PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
2557841-1	1989	Treatment of human platelets with concentrations of benzyl alcohol up to 50 mM augmented adenylate cyclase activity when it was assayed in the basal state and when stimulated by prostaglandin E1 (PGE1), isoprenaline or NaF.	Benzyl Alcohol	52-66	C-X-C motif chemokine ligand 8	Homo sapiens	219-222
2686646-2	1989	Potent inhibition of IL-8-induced migration was observed in response to nifedipine (IC50 = 10 nM), verapamil (IC50 = 60 nM) and diltiazem (IC50 = 10 nM).	Nifedipine	72-82	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
2686646-2	1989	Potent inhibition of IL-8-induced migration was observed in response to nifedipine (IC50 = 10 nM), verapamil (IC50 = 60 nM) and diltiazem (IC50 = 10 nM).	Verapamil	99-108	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
2686646-2	1989	Potent inhibition of IL-8-induced migration was observed in response to nifedipine (IC50 = 10 nM), verapamil (IC50 = 60 nM) and diltiazem (IC50 = 10 nM).	Diltiazem	128-137	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
2478657-0	1989	The neutrophil-activating peptide NAF/NAP-1 induces histamine and leukotriene release by interleukin 3-primed basophils.	Histamine	52-61	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
2681204-2	1989	The 1H-NMR spectrum of IL-8 is assigned in a sequential manner and regular elements of secondary structure are identified on the basis of a qualitative interpretation of the nuclear Overhauser, coupling constant and amide exchange data.	Hydrogen	4-6	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
2681204-4	1989	It is shown that IL-8 is a dimer in solution in which the interface is principally formed by six backbone hydrogen bonds between residues 25, 27, and 29 of one monomer and residues 29, 27, and 25, respectively, of the other.	Hydrogen	106-114	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
2478657-0	1989	The neutrophil-activating peptide NAF/NAP-1 induces histamine and leukotriene release by interleukin 3-primed basophils.	Histamine	52-61	C-X-C motif chemokine ligand 8	Homo sapiens	38-43
2478657-0	1989	The neutrophil-activating peptide NAF/NAP-1 induces histamine and leukotriene release by interleukin 3-primed basophils.	Leukotrienes	66-77	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
2549106-1	1989	This report reviews the methods and findings of published clinical studies comparing dentifrices containing sodium fluoride (NaF) and sodium monofluorophosphate (Na2PO3F) for the purpose of determining whether sodium fluoride formulations have superior cariostatic effects.	Sodium Fluoride	108-123	C-X-C motif chemokine ligand 8	Homo sapiens	125-128
2478657-0	1989	The neutrophil-activating peptide NAF/NAP-1 induces histamine and leukotriene release by interleukin 3-primed basophils.	Leukotrienes	66-77	C-X-C motif chemokine ligand 8	Homo sapiens	38-43
2478657-2	1989	This study demonstrates that after exposure to IL-3, basophils release histamine and leukotrienes in response to the neutrophil-activating peptide NAF/NAP-1.	Histamine	71-80	C-X-C motif chemokine ligand 8	Homo sapiens	147-150
2478657-2	1989	This study demonstrates that after exposure to IL-3, basophils release histamine and leukotrienes in response to the neutrophil-activating peptide NAF/NAP-1.	Histamine	71-80	C-X-C motif chemokine ligand 8	Homo sapiens	151-156
2478657-2	1989	This study demonstrates that after exposure to IL-3, basophils release histamine and leukotrienes in response to the neutrophil-activating peptide NAF/NAP-1.	Leukotrienes	85-97	C-X-C motif chemokine ligand 8	Homo sapiens	147-150
2478657-2	1989	This study demonstrates that after exposure to IL-3, basophils release histamine and leukotrienes in response to the neutrophil-activating peptide NAF/NAP-1.	Leukotrienes	85-97	C-X-C motif chemokine ligand 8	Homo sapiens	151-156
2560871-5	1989	After administration of sulprostone the adenylate cyclase activity was decreased 3- and 4.5-fold in response to specific stimulators NaF and forskolin, respectively, thus indicating that content and activity of G protein, and apparently of catalytic subunits, were decreased.	sulprostone	24-35	C-X-C motif chemokine ligand 8	Homo sapiens	133-136
2677006-1	1989	The interaction of 125I-labeled recombinant human neutrophil activating factor (NAF) with polymorphonuclear leukocytes (PMN) was studied by means of a radioreceptor assay.	Iodine-125	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	50-78
2677006-1	1989	The interaction of 125I-labeled recombinant human neutrophil activating factor (NAF) with polymorphonuclear leukocytes (PMN) was studied by means of a radioreceptor assay.	Iodine-125	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	80-83
2677006-3	1989	Internalized iodinated NAF was processed into trichloroacetic acid-soluble forms.	Trichloroacetic Acid	46-66	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
2675839-2	1989	Native LUCT and LU10 specifically induced the phosphorylation of 64 kD protein of PMN, and serine residue in the 64 kD protein was major phosphorylated amino acid.	Serine	91-97	C-X-C motif chemokine ligand 8	Homo sapiens	7-11
2675839-3	1989	Furthermore, native LUCT enhanced the release of myeloperoxidase and beta-glucuronidase from PMN in the presence of cytochalasin B and FMLP, but LU10 did not.	Cytochalasin B	116-130	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
2504305-5	1989	Markedly increased levels of GM-CSF mRNA occurred in these cells after exposure to sodium fluoride (NaF) and the effect of NaF was slightly enhanced by aluminum chloride; these results suggest that accumulation of GM-CSF mRNA can occur by activating a G-binding protein.	Aluminum Chloride	152-169	C-X-C motif chemokine ligand 8	Homo sapiens	123-126
2561629-4	1989	The combination consisting of 0.3% triclosan/2% PVM/MA copolymer/1100 ppm NaF was found to be highly effective on reducing smooth and fissure caries, and plaque extent compared to to 1100 ppm/NaF by itself in rats when applied topically.	Triclosan	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	192-195
2561629-4	1989	The combination consisting of 0.3% triclosan/2% PVM/MA copolymer/1100 ppm NaF was found to be highly effective on reducing smooth and fissure caries, and plaque extent compared to to 1100 ppm/NaF by itself in rats when applied topically.	copolymer	55-64	C-X-C motif chemokine ligand 8	Homo sapiens	192-195
2638180-6	1989	It was concluded that the 0.3% triclosan/PVM/MA copolymer/NaF test dentifrice provided effective delivery and bioavailability of the antiplaque agent, triclosan.	Triclosan	151-160	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
2547872-2	1989	Previous studies demonstrating hydrolysis of phosphatidylinositol bisphosphate (PIP2) and generation of inositol phosphates in neutrophils exposed to 20.0 mM NaF provide indirect evidence that activation of phospholipase-associated guanine nucleotide regulatory protein, a guanine nucleotide binding protein which regulates the activation of a membrane inositol-specific phospholipase C, is an early event in the neutrophil stimulus-response pathway triggered by fluoride.	phosphatidylinositol bisphosphate	45-78	C-X-C motif chemokine ligand 8	Homo sapiens	158-161
2547872-2	1989	Previous studies demonstrating hydrolysis of phosphatidylinositol bisphosphate (PIP2) and generation of inositol phosphates in neutrophils exposed to 20.0 mM NaF provide indirect evidence that activation of phospholipase-associated guanine nucleotide regulatory protein, a guanine nucleotide binding protein which regulates the activation of a membrane inositol-specific phospholipase C, is an early event in the neutrophil stimulus-response pathway triggered by fluoride.	Phosphates	113-123	C-X-C motif chemokine ligand 8	Homo sapiens	158-161
2547872-2	1989	Previous studies demonstrating hydrolysis of phosphatidylinositol bisphosphate (PIP2) and generation of inositol phosphates in neutrophils exposed to 20.0 mM NaF provide indirect evidence that activation of phospholipase-associated guanine nucleotide regulatory protein, a guanine nucleotide binding protein which regulates the activation of a membrane inositol-specific phospholipase C, is an early event in the neutrophil stimulus-response pathway triggered by fluoride.	Phosphatidylinositol 4,5-Diphosphate	80-84	C-X-C motif chemokine ligand 8	Homo sapiens	158-161
2788065-2	1989	One hundred and forty-two children, of whom 56 had participated in a fluoride tablet program of 0.5/1.0 mg NaF per day were examined blindly for possible fluoride-induced enamel changes.	Fluorides	69-77	C-X-C motif chemokine ligand 8	Homo sapiens	107-110
2547872-2	1989	Previous studies demonstrating hydrolysis of phosphatidylinositol bisphosphate (PIP2) and generation of inositol phosphates in neutrophils exposed to 20.0 mM NaF provide indirect evidence that activation of phospholipase-associated guanine nucleotide regulatory protein, a guanine nucleotide binding protein which regulates the activation of a membrane inositol-specific phospholipase C, is an early event in the neutrophil stimulus-response pathway triggered by fluoride.	Fluorides	463-471	C-X-C motif chemokine ligand 8	Homo sapiens	158-161
2547872-3	1989	Consistent with this hypothesis, exposure of a plasma membrane rich preparation isolated from 32P labeled neutrophils to 20.0 mM NaF resulted in hydrolysis of labeled PIP2.	Phosphorus-32	94-97	C-X-C motif chemokine ligand 8	Homo sapiens	129-132
2547872-3	1989	Consistent with this hypothesis, exposure of a plasma membrane rich preparation isolated from 32P labeled neutrophils to 20.0 mM NaF resulted in hydrolysis of labeled PIP2.	Phosphatidylinositol 4,5-Diphosphate	167-171	C-X-C motif chemokine ligand 8	Homo sapiens	129-132
2549166-0	1989	The monocyte-derived neutrophil activating peptide (NAP/interleukin 8) stimulates human neutrophil arachidonate-5-lipoxygenase, but not the release of cellular arachidonate.	Arachidonic Acid	99-111	C-X-C motif chemokine ligand 8	Homo sapiens	4-50
2549166-0	1989	The monocyte-derived neutrophil activating peptide (NAP/interleukin 8) stimulates human neutrophil arachidonate-5-lipoxygenase, but not the release of cellular arachidonate.	Arachidonic Acid	99-111	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
2476383-0	1989	Neutrophil attractant/activation protein-1 (NAP-1) causes human basophil histamine release.	Histamine	73-82	C-X-C motif chemokine ligand 8	Homo sapiens	0-42
2510716-3	1989	In the present study, we have attempted to locate the site of action of phorbol ester by comparing thrombin-induced (i.e. receptor-mediated) platelet activation with that induced by guanosine 5"-[gamma-thio]triphosphate (GTP[S]) and NaF, two agents which by-pass the receptor and initiate platelet responses by directly modulating G-protein function.	Phorbol Esters	72-85	C-X-C motif chemokine ligand 8	Homo sapiens	233-236
2510716-4	1989	After a 10 s pre-treatment with PMA (16 nM), dense-granule secretion induced by thrombin (0.2 unit/ml), GTP[S] (40 microM) and NaF (30 mM) was potentiated, resulting in a greater than additive response to agent plus PMA.	Tetradecanoylphorbol Acetate	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	127-130
2510716-4	1989	After a 10 s pre-treatment with PMA (16 nM), dense-granule secretion induced by thrombin (0.2 unit/ml), GTP[S] (40 microM) and NaF (30 mM) was potentiated, resulting in a greater than additive response to agent plus PMA.	Tetradecanoylphorbol Acetate	216-219	C-X-C motif chemokine ligand 8	Homo sapiens	127-130
2510716-5	1989	However, after a 5 min pre-treatment, thrombin-induced secretion alone was inhibited, whereas PMA plus GTP[S]/NaF-induced release remained greater than additive.	Guanosine Triphosphate	103-106	C-X-C motif chemokine ligand 8	Homo sapiens	110-113
2776689-1	1989	Exposure of fresh water crab Barytelphusa querini to a sublethal concentration of NaF (30 ppm) caused significant alterations in the carbohydrate metabolism.	Carbohydrates	133-145	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
2476383-1	1989	Basophils from five of six human donors released histamine in response to neutrophil attractant/activation protein-1 (NAP-1).	Histamine	49-58	C-X-C motif chemokine ligand 8	Homo sapiens	118-123
2476383-0	1989	Neutrophil attractant/activation protein-1 (NAP-1) causes human basophil histamine release.	Histamine	73-82	C-X-C motif chemokine ligand 8	Homo sapiens	44-49
2510716-7	1989	That secretion induced by these agents is a protein kinase C-dependent event was demonstrable by using staurosporine, a protein kinase C inhibitor which at concentrations of 1-10 nM inhibited (70-90%) PMA-induced as well as thrombin- and NaF-induced secretion and protein phosphorylation.	Staurosporine	103-116	C-X-C motif chemokine ligand 8	Homo sapiens	238-241
2510716-7	1989	That secretion induced by these agents is a protein kinase C-dependent event was demonstrable by using staurosporine, a protein kinase C inhibitor which at concentrations of 1-10 nM inhibited (70-90%) PMA-induced as well as thrombin- and NaF-induced secretion and protein phosphorylation.	Tetradecanoylphorbol Acetate	201-204	C-X-C motif chemokine ligand 8	Homo sapiens	238-241
2476383-1	1989	Basophils from five of six human donors released histamine in response to neutrophil attractant/activation protein-1 (NAP-1).	Histamine	49-58	C-X-C motif chemokine ligand 8	Homo sapiens	74-116
2746239-8	1989	Preincubation of aluminum with citrate, NADP+, EDTA, NaF, ATP, and apotransferrin protected the G6PD isozymes against aluminum inactivation.	Aluminum	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
2768695-1	1989	This study determined the effect of brushing with 0.4% stannous fluoride (SnF2) or 0.22% sodium fluoride (NaF) on clinical and microbial parameters associated with gingivitis.	Sodium Fluoride	89-104	C-X-C motif chemokine ligand 8	Homo sapiens	106-109
2746239-8	1989	Preincubation of aluminum with citrate, NADP+, EDTA, NaF, ATP, and apotransferrin protected the G6PD isozymes against aluminum inactivation.	Aluminum	118-126	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
2746239-10	1989	The dissociation constants for the enzyme-aluminum complex of the isozymes varied from 2 to 4 microM, as measured by using NaF, a known chelator for aluminum.	Aluminum	42-50	C-X-C motif chemokine ligand 8	Homo sapiens	123-126
2746239-10	1989	The dissociation constants for the enzyme-aluminum complex of the isozymes varied from 2 to 4 microM, as measured by using NaF, a known chelator for aluminum.	Aluminum	149-157	C-X-C motif chemokine ligand 8	Homo sapiens	123-126
2659722-1	1989	A chemotactic protein for polymorphonuclear leukocytes (lung carcinoma-derived chemotaxin [LUCT]) was purified from culture fluid of the human lung giant cell carcinoma LU65C cells to electrophoretically homogeneous form through five sequential purification steps: DEAE-Sepharose, CM-Sepharose, HPLC on carboxyl-methylated-polyvinylalcohol resin, hydrophobic, and reversed-phase.	deae-sepharose	265-279	C-X-C motif chemokine ligand 8	Homo sapiens	56-89
2668365-1	1989	A three-year clinical trial was conducted to determine whether a sodium fluoride (NaF) dentifrice had greater cariostatic effects than a sodium monofluorophosphate (Na2PO3F) dentifrice.	Sodium Fluoride	65-80	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
2662972-6	1989	Amino acid composition of CINC showed that CINC has a resemblance to human monocyte-derived neutrophil chemotactic factor (MDNCF) rather than human complement fragment, C5a.	Zinc	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	75-121
2662972-6	1989	Amino acid composition of CINC showed that CINC has a resemblance to human monocyte-derived neutrophil chemotactic factor (MDNCF) rather than human complement fragment, C5a.	Zinc	43-47	C-X-C motif chemokine ligand 8	Homo sapiens	75-121
2662972-6	1989	Amino acid composition of CINC showed that CINC has a resemblance to human monocyte-derived neutrophil chemotactic factor (MDNCF) rather than human complement fragment, C5a.	Zinc	43-47	C-X-C motif chemokine ligand 8	Homo sapiens	123-128
2550298-6	1989	NaF (20 mM) mimicked the stimulatory effect of PGF2 alpha on inositol phosphate accumulation suggesting the involvement of a guanine nucleotide regulatory protein in the activation of phospholipase C. In contrast, hCG but not PGF2 alpha or NaF stimulated cAMP accumulation in 30 min incubations.	Dinoprost	47-51	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2550298-6	1989	NaF (20 mM) mimicked the stimulatory effect of PGF2 alpha on inositol phosphate accumulation suggesting the involvement of a guanine nucleotide regulatory protein in the activation of phospholipase C. In contrast, hCG but not PGF2 alpha or NaF stimulated cAMP accumulation in 30 min incubations.	Dinoprost	47-51	C-X-C motif chemokine ligand 8	Homo sapiens	240-243
2550298-6	1989	NaF (20 mM) mimicked the stimulatory effect of PGF2 alpha on inositol phosphate accumulation suggesting the involvement of a guanine nucleotide regulatory protein in the activation of phospholipase C. In contrast, hCG but not PGF2 alpha or NaF stimulated cAMP accumulation in 30 min incubations.	Inositol Phosphates	61-79	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2550298-6	1989	NaF (20 mM) mimicked the stimulatory effect of PGF2 alpha on inositol phosphate accumulation suggesting the involvement of a guanine nucleotide regulatory protein in the activation of phospholipase C. In contrast, hCG but not PGF2 alpha or NaF stimulated cAMP accumulation in 30 min incubations.	Dinoprost	47-57	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2550298-6	1989	NaF (20 mM) mimicked the stimulatory effect of PGF2 alpha on inositol phosphate accumulation suggesting the involvement of a guanine nucleotide regulatory protein in the activation of phospholipase C. In contrast, hCG but not PGF2 alpha or NaF stimulated cAMP accumulation in 30 min incubations.	Dinoprost	47-57	C-X-C motif chemokine ligand 8	Homo sapiens	240-243
2550298-6	1989	NaF (20 mM) mimicked the stimulatory effect of PGF2 alpha on inositol phosphate accumulation suggesting the involvement of a guanine nucleotide regulatory protein in the activation of phospholipase C. In contrast, hCG but not PGF2 alpha or NaF stimulated cAMP accumulation in 30 min incubations.	Cyclic AMP	255-259	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
9992051-0	1989	Spin-multiplet electronic transition energies in NaF:Cu+ by the self-interaction-corrected local-spin-density approximation.	Copper	53-55	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
2659722-1	1989	A chemotactic protein for polymorphonuclear leukocytes (lung carcinoma-derived chemotaxin [LUCT]) was purified from culture fluid of the human lung giant cell carcinoma LU65C cells to electrophoretically homogeneous form through five sequential purification steps: DEAE-Sepharose, CM-Sepharose, HPLC on carboxyl-methylated-polyvinylalcohol resin, hydrophobic, and reversed-phase.	deae-sepharose	265-279	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
2659722-1	1989	A chemotactic protein for polymorphonuclear leukocytes (lung carcinoma-derived chemotaxin [LUCT]) was purified from culture fluid of the human lung giant cell carcinoma LU65C cells to electrophoretically homogeneous form through five sequential purification steps: DEAE-Sepharose, CM-Sepharose, HPLC on carboxyl-methylated-polyvinylalcohol resin, hydrophobic, and reversed-phase.	Curium	281-284	C-X-C motif chemokine ligand 8	Homo sapiens	56-89
2659722-1	1989	A chemotactic protein for polymorphonuclear leukocytes (lung carcinoma-derived chemotaxin [LUCT]) was purified from culture fluid of the human lung giant cell carcinoma LU65C cells to electrophoretically homogeneous form through five sequential purification steps: DEAE-Sepharose, CM-Sepharose, HPLC on carboxyl-methylated-polyvinylalcohol resin, hydrophobic, and reversed-phase.	Curium	281-284	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
2659722-1	1989	A chemotactic protein for polymorphonuclear leukocytes (lung carcinoma-derived chemotaxin [LUCT]) was purified from culture fluid of the human lung giant cell carcinoma LU65C cells to electrophoretically homogeneous form through five sequential purification steps: DEAE-Sepharose, CM-Sepharose, HPLC on carboxyl-methylated-polyvinylalcohol resin, hydrophobic, and reversed-phase.	Sepharose	270-279	C-X-C motif chemokine ligand 8	Homo sapiens	56-89
2659722-1	1989	A chemotactic protein for polymorphonuclear leukocytes (lung carcinoma-derived chemotaxin [LUCT]) was purified from culture fluid of the human lung giant cell carcinoma LU65C cells to electrophoretically homogeneous form through five sequential purification steps: DEAE-Sepharose, CM-Sepharose, HPLC on carboxyl-methylated-polyvinylalcohol resin, hydrophobic, and reversed-phase.	Sepharose	270-279	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
2659722-1	1989	A chemotactic protein for polymorphonuclear leukocytes (lung carcinoma-derived chemotaxin [LUCT]) was purified from culture fluid of the human lung giant cell carcinoma LU65C cells to electrophoretically homogeneous form through five sequential purification steps: DEAE-Sepharose, CM-Sepharose, HPLC on carboxyl-methylated-polyvinylalcohol resin, hydrophobic, and reversed-phase.	carboxyl-methylated-polyvinylalcohol	303-339	C-X-C motif chemokine ligand 8	Homo sapiens	56-89
2659722-1	1989	A chemotactic protein for polymorphonuclear leukocytes (lung carcinoma-derived chemotaxin [LUCT]) was purified from culture fluid of the human lung giant cell carcinoma LU65C cells to electrophoretically homogeneous form through five sequential purification steps: DEAE-Sepharose, CM-Sepharose, HPLC on carboxyl-methylated-polyvinylalcohol resin, hydrophobic, and reversed-phase.	carboxyl-methylated-polyvinylalcohol	303-339	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
9948930-0	1989	Molecular-dynamics simulation of positive-ion and neutral halogen desorption following Na K-shell Auger cascades in the NaF crystal.	Halogens	58-65	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
2666307-3	1989	When combined with prostaglandin E2(PGE2), MONAP caused a marked and synergistic increase in PMNL infiltration and plasma extravasation into the injected skin sites.	Dinoprostone	19-35	C-X-C motif chemokine ligand 8	Homo sapiens	43-48
2666307-3	1989	When combined with prostaglandin E2(PGE2), MONAP caused a marked and synergistic increase in PMNL infiltration and plasma extravasation into the injected skin sites.	Dinoprostone	36-40	C-X-C motif chemokine ligand 8	Homo sapiens	43-48
2523801-3	1989	Although GCP/IL-8 and beta-thromboglobulin had a similar affinity for heparin, they could be separated on a cation-exchange column.	Heparin	70-77	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
2732364-4	1989	Addition of NaF solution to aluminium- and calcium-containing abrasives resulted in losses of 60-90 per cent of the added F after 1 week"s storage at room temperature.	Aluminum	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
2732364-4	1989	Addition of NaF solution to aluminium- and calcium-containing abrasives resulted in losses of 60-90 per cent of the added F after 1 week"s storage at room temperature.	Calcium	43-50	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
2732364-7	1989	Silica was inert in binding and inactivating F of NaF and Na2PO3F (MFP).	Silicon Dioxide	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
2732364-8	1989	Calcium-containing abrasives were markedly more compatible with MFP than with NaF.	Calcium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	78-81
2500593-12	1989	The types of aberrations, mostly deletions and gaps, the induction of endoreduplicated cells, the cell-cycle delay and the sensitivity of G2 cells to NaF observed are similar to that reported in the literature for DNA synthesis/repair inhibitors like aphidicolin (APC).	Aphidicolin	251-262	C-X-C motif chemokine ligand 8	Homo sapiens	150-153
2664463-5	1989	Actinomycin D chase experiments yielded evidence that cytoplasmic stabilization was one of the means of regulation of MONAP expression.	Dactinomycin	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	118-123
2557868-0	1989	Fluoride uptake from NaF/pyrophosphate anticalculus dentifrices in vitro: effect of pyrophosphate dose.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
2484420-3	1989	Using laser microprobe mass analysis, the localization of lead and fluoride was studied in the different layers or tooth germs that had been cultured in a medium to which PbCl2 of NaF had been added in different concentrations.	lead chloride	171-176	C-X-C motif chemokine ligand 8	Homo sapiens	180-183
2648385-6	1989	Thus, GDCF and MDNCF have a similar gross secondary structure because of the loops formed by the clustered disulfides, and their different leukocyte specificities are most likely determined by the large differences in primary sequence.	Disulfides	107-117	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
2918134-1	1989	Previous work showed that plaque fluoride increased with increasing NaF content of mouthwashes following daily use.	Fluorides	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
2918136-1	1989	Submandibular/sublingual saliva and blood were collected from five subjects after ingestion of 1 mg fluoride as NaF.	Fluorides	100-108	C-X-C motif chemokine ligand 8	Homo sapiens	112-115
2647892-4	1989	Based on the SDS-PAGE analysis of chemically crosslinked 125I-MDNCF receptor complex, there are two polypeptides that bind MDNCF; the molecular weight of these two MDNCF receptors were estimated to be 67,000 and 59,000.	Sodium Dodecyl Sulfate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	62-67
2647892-4	1989	Based on the SDS-PAGE analysis of chemically crosslinked 125I-MDNCF receptor complex, there are two polypeptides that bind MDNCF; the molecular weight of these two MDNCF receptors were estimated to be 67,000 and 59,000.	Sodium Dodecyl Sulfate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	123-128
2647892-4	1989	Based on the SDS-PAGE analysis of chemically crosslinked 125I-MDNCF receptor complex, there are two polypeptides that bind MDNCF; the molecular weight of these two MDNCF receptors were estimated to be 67,000 and 59,000.	Sodium Dodecyl Sulfate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	123-128
2566599-3	1989	The chemical shifts, which are referenced to 20 mM NaF in 50 mM sodium phosphate, pH 7.0, were 6.0, 8.2, and 11.9 ppm for free o-, m-, and p-fluorobenzoates, respectively, while those of o-, m-, and p-fluorobenzoates bound to DAO were 12.5, 5.4, and 13.1 ppm, respectively.	sodium phosphate	64-80	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
2566599-3	1989	The chemical shifts, which are referenced to 20 mM NaF in 50 mM sodium phosphate, pH 7.0, were 6.0, 8.2, and 11.9 ppm for free o-, m-, and p-fluorobenzoates, respectively, while those of o-, m-, and p-fluorobenzoates bound to DAO were 12.5, 5.4, and 13.1 ppm, respectively.	fluorobenzoates	141-156	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
2566599-3	1989	The chemical shifts, which are referenced to 20 mM NaF in 50 mM sodium phosphate, pH 7.0, were 6.0, 8.2, and 11.9 ppm for free o-, m-, and p-fluorobenzoates, respectively, while those of o-, m-, and p-fluorobenzoates bound to DAO were 12.5, 5.4, and 13.1 ppm, respectively.	, and p-fluorobenzoates	133-156	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
2736581-5	1989	The results show that F absorption from MFP in milk is as high as that of NaF in water under fasting conditions and that the F bioavailability decrease from NaF in water is more important than that of MFP in milk when F ingestion occurs simultaneously with food intake.	Water	81-86	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
2790854-1	1989	Specimens of human dental enamel were topically applied with solutions of sodium fluoride (NaF) or acidulated phosphate fluoride (APF) before and after laser irradiation.	Sodium Fluoride	74-89	C-X-C motif chemokine ligand 8	Homo sapiens	91-94
2790854-5	1989	NaF application caused lesser acid resistance and lesser fluoride uptake than APF application, even when the enamel was treated with laser irradiation.	Fluorides	57-65	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2790857-2	1989	The saliva was collected continuously for 120 min after ingestion of 1 mg fluoride as NaF.	Fluorides	74-82	C-X-C motif chemokine ligand 8	Homo sapiens	86-89
2561943-2	1989	LiCl, BeCl2 and NaF inhibited the hydrolysis of both monophosphates with half maximal inhibition occurring at 1.2 mM, 0.3 microM, 0.25 mM (Ins 1P) and 0.14 mM, 0.56 microM, 0.28 mM (Ins 4P) respectively.	monophosphates	53-67	C-X-C motif chemokine ligand 8	Homo sapiens	16-19
2736581-5	1989	The results show that F absorption from MFP in milk is as high as that of NaF in water under fasting conditions and that the F bioavailability decrease from NaF in water is more important than that of MFP in milk when F ingestion occurs simultaneously with food intake.	Water	164-169	C-X-C motif chemokine ligand 8	Homo sapiens	157-160
2910959-0	1989	Influence of milk and food on fluoride bioavailability from NaF and Na2FPO3 in man.	Fluorides	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
2714300-3	1989	The uptake of 67Ga into tumor cells was inhibited by adding NaF which is an inhibitor of ATP production.	Adenosine Triphosphate	89-92	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
2648135-1	1989	Human monocyte-derived neutrophil chemotactic factor (MDNCF) was purified from culture supernatant of lipopolysaccharide-stimulated human peripheral blood mononuclear leukocytes on a column of Sepharose-bound murine monoclonal anti-MDNCF.	Sepharose	193-202	C-X-C motif chemokine ligand 8	Homo sapiens	6-52
2642504-7	1989	beta-ENAP shows biochemical and biologic similarities to monocyte- and lymphocyte-derived neutrophil-activating peptides MONAP and LYNAP, which recently were purified and sequenced.	(2-benzoylethyl)trimethylammonium	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	131-136
2642504-7	1989	beta-ENAP shows biochemical and biologic similarities to monocyte- and lymphocyte-derived neutrophil-activating peptides MONAP and LYNAP, which recently were purified and sequenced.	Enalapril maleate	5-9	C-X-C motif chemokine ligand 8	Homo sapiens	131-136
2648135-1	1989	Human monocyte-derived neutrophil chemotactic factor (MDNCF) was purified from culture supernatant of lipopolysaccharide-stimulated human peripheral blood mononuclear leukocytes on a column of Sepharose-bound murine monoclonal anti-MDNCF.	Sepharose	193-202	C-X-C motif chemokine ligand 8	Homo sapiens	54-59
2689542-8	1989	CaF2 production amounts were relatively higher in a group of one time 2% NaF application with the use of F-ion than those of control group as only fluoride solution applicated and it were the most in a group of 10 times fluoride application with the use of F-ion, through the examining by X-ray diffractometer, so it was estimated that F-ion technique of fluoride application would increase the fluoride penetration effect.	Fluorides	147-155	C-X-C motif chemokine ligand 8	Homo sapiens	73-76
2850702-3	1988	The results showed that the CaF2-like material deposited on enamel after a topical treatment with 2% NaF dissolved almost completely in the 1 M HClO4 and 1.6 N HCl/70% glycerol solutions.	Perchloric Acid	144-149	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
2848025-5	1988	Incubation of the cells with NaF also induced mobilization of the same Ca2+ stores released in response to extracellular ATP; this provided indirect evidence that the transmembrane signaling actions of P2-purinergic receptors may be mediated by GTP-binding regulatory proteins.	Adenosine Triphosphate	121-124	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
2850702-3	1988	The results showed that the CaF2-like material deposited on enamel after a topical treatment with 2% NaF dissolved almost completely in the 1 M HClO4 and 1.6 N HCl/70% glycerol solutions.	Hydrochloric Acid	144-147	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
2848025-5	1988	Incubation of the cells with NaF also induced mobilization of the same Ca2+ stores released in response to extracellular ATP; this provided indirect evidence that the transmembrane signaling actions of P2-purinergic receptors may be mediated by GTP-binding regulatory proteins.	Guanosine Triphosphate	245-248	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
3057503-5	1988	Recombinant NAF purified to homogeneity had identical amino- and carboxyl-terminal sequences to the 72-amino acid natural NAF.	72-amino acid	100-113	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
2904148-3	1988	The identical pattern of inhibition of F1-type ATPase activity obtained in the presence of ADP and NaF with beryllium, a metal that forms fluoride complexes strictly tetracoordinated, suggests that aluminum acts through a tetrahedral complex.	Beryllium	108-117	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
3213443-5	1988	Calcium fluoride-like material, formed on enamel by treatment with 2% NaF solution, was shown by scanning electron microscopy to have higher stability in saliva than in water after 3 weeks" incubation.	Calcium Fluoride	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	70-73
3213443-5	1988	Calcium fluoride-like material, formed on enamel by treatment with 2% NaF solution, was shown by scanning electron microscopy to have higher stability in saliva than in water after 3 weeks" incubation.	Water	169-174	C-X-C motif chemokine ligand 8	Homo sapiens	70-73
2904148-3	1988	The identical pattern of inhibition of F1-type ATPase activity obtained in the presence of ADP and NaF with beryllium, a metal that forms fluoride complexes strictly tetracoordinated, suggests that aluminum acts through a tetrahedral complex.	Metals	121-126	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
3057503-5	1988	Recombinant NAF purified to homogeneity had identical amino- and carboxyl-terminal sequences to the 72-amino acid natural NAF.	72-amino acid	100-113	C-X-C motif chemokine ligand 8	Homo sapiens	122-125
2904148-3	1988	The identical pattern of inhibition of F1-type ATPase activity obtained in the presence of ADP and NaF with beryllium, a metal that forms fluoride complexes strictly tetracoordinated, suggests that aluminum acts through a tetrahedral complex.	Fluorides	138-146	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
3044830-3	1988	MDNCF forms two loops via a neighboring pair of disulfide bridges, the probable locations of which are residues 7-34 and 9-50.	Disulfides	48-57	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
2904148-3	1988	The identical pattern of inhibition of F1-type ATPase activity obtained in the presence of ADP and NaF with beryllium, a metal that forms fluoride complexes strictly tetracoordinated, suggests that aluminum acts through a tetrahedral complex.	Aluminum	198-206	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
3211715-7	1988	NaF (5 mmol/l) increased [Cai2+] to 412 +/- 88 nmol/l in control cells and was equally effective in cells desensitized to bradykinin.	cai2+	26-31	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2846571-3	1988	Adenylate cyclase can be stimulated by vanadate, which, like NaF, probably acts through Gs.	Vanadates	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	61-64
9945944-0	1988	Electronic structure and optical properties of the impurity Cu+ in NaF.	Copper	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
3165239-7	1988	Daily fluoride mouth rinsing with a 0.2% solution sodium fluoride (NaF) retarded lesion development significantly, whereas the fluoride solution with low pH inhibited lesion formation completely.	Fluorides	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
3165239-7	1988	Daily fluoride mouth rinsing with a 0.2% solution sodium fluoride (NaF) retarded lesion development significantly, whereas the fluoride solution with low pH inhibited lesion formation completely.	Sodium Fluoride	50-65	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
3165239-7	1988	Daily fluoride mouth rinsing with a 0.2% solution sodium fluoride (NaF) retarded lesion development significantly, whereas the fluoride solution with low pH inhibited lesion formation completely.	Fluorides	57-65	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
3260265-3	1988	Comparison of the deduced amino acid sequence with the NH2-terminal amino acid sequence of natural MDNCF shows that the mature functional protein comprises 72 amino acids, beginning with serine at residue 28.	Serine	187-193	C-X-C motif chemokine ligand 8	Homo sapiens	99-104
3214557-0	1988	In situ fluoride uptake from NaF dentifrices: dose response and effects of a novel enhanced delivery system.	Fluorides	8-16	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
3214558-0	1988	In situ fluoride uptake from 0.05% neutral NaF mouthrinses: effects of a novel enhanced delivery system.	Fluorides	8-16	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
2845938-9	1988	AlF4- probably binds to the phosphate-binding site of the ATPase, as the Ki for inhibition of the (Na+ + K+)-ATPase and of the plasmalemmal (Ca2+ + Mg2+)-ATPase is shifted in the presence of respectively 5 and 50 mM-Pi to higher concentrations of NaF.	Phosphates	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	247-250
2840318-5	1988	Two conclusions are drawn from these results: 1) neutrophil activation by NAF (as by fMLP) is dependent on a GTP-binding protein and on protein kinase C; 2) a similar, or even identical, mechanism of signal transduction must be assumed on stimulation of human neutrophils with NAF, fMLP, and other chemotactic agonists.	Guanosine Triphosphate	109-112	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
3282512-3	1988	Analytic isoelecto-focusing of pure MONAP (single line upon sodiumdodecylsulfate polyacrylamide gel electrophoresis, single peak after RP-18-HPLC), obtained by size exclusion HPLC followed by two different reversed phase HPLC steps revealed charge heterogeneity giving major components with isoelectric points at 4.7, 4.9, 6.4 and 6.9, all of which exhibited chemotactic activity.	Sodium Dodecyl Sulfate	60-80	C-X-C motif chemokine ligand 8	Homo sapiens	36-41
3283118-5	1988	Ins-1,4,5-P3 formation was also increased by NaF, further indicating the involvement of a guanine nucleotide regulatory protein.	Inositol 1,4,5-Trisphosphate	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
3283239-5	1988	LYNAP stimulated neutrophil chemotaxis (ED50 of 3 +/- 3 ng/ml), chemokinesis (ED50 of 2 +/- 2 ng/ml), and caused degranulation of cytochalasin B pretreated human neutrophils (ED50 of 20 ng/ml).	Cytochalasin B	130-144	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
3282512-3	1988	Analytic isoelecto-focusing of pure MONAP (single line upon sodiumdodecylsulfate polyacrylamide gel electrophoresis, single peak after RP-18-HPLC), obtained by size exclusion HPLC followed by two different reversed phase HPLC steps revealed charge heterogeneity giving major components with isoelectric points at 4.7, 4.9, 6.4 and 6.9, all of which exhibited chemotactic activity.	polyacrylamide	81-95	C-X-C motif chemokine ligand 8	Homo sapiens	36-41
2833319-2	1988	In both groups, significant inverse correlations were observed when 24-hr urinary catecholamine levels were examined in relation to measures of both receptor-mediated (prostaglandin D2 and alpha 2-adrenergic) and postreceptor-mediated (NaF) platelet AC enzyme activities, suggesting that circulating catecholamines may regulate platelet AC by heterologous (agonist-nonspecific) desensitization of the AC enzyme complex.	Catecholamines	82-95	C-X-C motif chemokine ligand 8	Homo sapiens	236-239
3271662-0	1988	[Trials of increasing the ability of enamel enrichment with fluorine by adding NaF and Na2PO3F to toothpastes.	Fluorine	60-68	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
3366793-1	1988	Con A, NaF, and eserine (lysosomotropic agents) induced marked translocation of acidic [3H] nonhistone proteins (NHP) from the cytoplasm to the nucleus in lymphocytes prelabeled with [3H]-2-mannose.	Tritium	88-90	C-X-C motif chemokine ligand 8	Homo sapiens	7-10
3366793-1	1988	Con A, NaF, and eserine (lysosomotropic agents) induced marked translocation of acidic [3H] nonhistone proteins (NHP) from the cytoplasm to the nucleus in lymphocytes prelabeled with [3H]-2-mannose.	Tritium	184-186	C-X-C motif chemokine ligand 8	Homo sapiens	7-10
3366793-1	1988	Con A, NaF, and eserine (lysosomotropic agents) induced marked translocation of acidic [3H] nonhistone proteins (NHP) from the cytoplasm to the nucleus in lymphocytes prelabeled with [3H]-2-mannose.	2-mannose	188-197	C-X-C motif chemokine ligand 8	Homo sapiens	7-10
3366793-5	1988	Con A and NaF caused also nuclear translocation of acidic [3H] NHP in cells labeled with [3H] glucosamine, [3H] galactose, or [3H] fucose.	Tritium	59-61	C-X-C motif chemokine ligand 8	Homo sapiens	10-13
3366793-5	1988	Con A and NaF caused also nuclear translocation of acidic [3H] NHP in cells labeled with [3H] glucosamine, [3H] galactose, or [3H] fucose.	[3h] glucosamine	89-105	C-X-C motif chemokine ligand 8	Homo sapiens	10-13
3366793-5	1988	Con A and NaF caused also nuclear translocation of acidic [3H] NHP in cells labeled with [3H] glucosamine, [3H] galactose, or [3H] fucose.	3h] galactose	108-121	C-X-C motif chemokine ligand 8	Homo sapiens	10-13
3366793-5	1988	Con A and NaF caused also nuclear translocation of acidic [3H] NHP in cells labeled with [3H] glucosamine, [3H] galactose, or [3H] fucose.	Tritium	90-92	C-X-C motif chemokine ligand 8	Homo sapiens	10-13
3366793-5	1988	Con A and NaF caused also nuclear translocation of acidic [3H] NHP in cells labeled with [3H] glucosamine, [3H] galactose, or [3H] fucose.	Fucose	131-137	C-X-C motif chemokine ligand 8	Homo sapiens	10-13
3248408-0	1988	[Fluorine content of the superficial enamel layer after application in vitro of pastes with varying concentrations of Na2PO3F or NaF].	Fluorine	1-9	C-X-C motif chemokine ligand 8	Homo sapiens	129-132
3123517-11	1988	Lactate, the principal product of resting neutrophil glucose catabolism, was demonstrable in cell-free supernatants after incubation at 37 degrees C. Lactate accumulation was inhibited by NaF and decreased temperature of incubation.	Lactic Acid	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	188-191
2452749-7	1988	The diminished response of the enzyme to GTP and NaF pointed to an involvement of the stimulatory guanyl nucleotide-binding protein (Gs) in iloprost-induced heterologous desensitization.	Iloprost	140-148	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
3348776-1	1988	The ability of sodium fluoride (NaF) and thrombin to stimulate aggregation and protein phosphorylation in intact human platelets was measured and compared.	Sodium Fluoride	15-30	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
3348776-5	1988	Phosphoamino acid analysis showed that the phosphorylated amino acids of the 47 KDa protein from platelets activated by NaF and thrombin were slightly different.	Phosphoamino Acids	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
3123517-11	1988	Lactate, the principal product of resting neutrophil glucose catabolism, was demonstrable in cell-free supernatants after incubation at 37 degrees C. Lactate accumulation was inhibited by NaF and decreased temperature of incubation.	Lactic Acid	150-157	C-X-C motif chemokine ligand 8	Homo sapiens	188-191
3126375-1	1988	The sensitivity of fibroblasts (L cells) to low concentrations of sodium fluoride (NaF) was examined using the same cell during a series of stimuli.	Sodium Fluoride	66-81	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
2838616-4	1988	0.2-0.3 mM fatty acids increased adenylate cyclase activity, while higher concentrations of arachidonic and linoleic acids, but not oleic acid, inhibited basal, beta-agonist- and NaF-stimulated activities in membranes of A431 and C6 cells.	Fatty Acids	11-22	C-X-C motif chemokine ligand 8	Homo sapiens	179-182
2838616-4	1988	0.2-0.3 mM fatty acids increased adenylate cyclase activity, while higher concentrations of arachidonic and linoleic acids, but not oleic acid, inhibited basal, beta-agonist- and NaF-stimulated activities in membranes of A431 and C6 cells.	arachidonic	92-103	C-X-C motif chemokine ligand 8	Homo sapiens	179-182
2838616-4	1988	0.2-0.3 mM fatty acids increased adenylate cyclase activity, while higher concentrations of arachidonic and linoleic acids, but not oleic acid, inhibited basal, beta-agonist- and NaF-stimulated activities in membranes of A431 and C6 cells.	Linoleic Acids	108-122	C-X-C motif chemokine ligand 8	Homo sapiens	179-182
2838616-4	1988	0.2-0.3 mM fatty acids increased adenylate cyclase activity, while higher concentrations of arachidonic and linoleic acids, but not oleic acid, inhibited basal, beta-agonist- and NaF-stimulated activities in membranes of A431 and C6 cells.	Oleic Acid	111-121	C-X-C motif chemokine ligand 8	Homo sapiens	179-182
2824608-1	1987	A novel monocyte-derived neutrophil-activating peptide (MONAP) produced by lipopolysaccharide- and phorbol myristate acetate-stimulated human peripheral blood monocytes was purified by sequential ion exchange-high performance liquid chromatography (HPLC), size exclusion HPLC, and reversed phase HPLC.	Tetradecanoylphorbol Acetate	99-124	C-X-C motif chemokine ligand 8	Homo sapiens	8-54
2826233-1	1987	The free modulator subunit of the ATP,Mg-dependent phosphatase is phosphorylated up to 1 mol per mol by casein kinase-1, up to 1.85 mol per mol after dephosphorylation by the PCSH1 phosphatase, but 10-fold less when purified in the presence of NaF, suggesting an in vivo phosphorylation of the casein kinase-1 sites.	Adenosine Triphosphate	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	244-247
2839752-4	1988	In the presence of AlCl3 NaF stimulated the release of inositol phosphates in the cytotoxin-treated JURKAT cells.	Inositol Phosphates	55-74	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
2839752-5	1988	NaF plus AlCl3 induced increases in inositol tris-, bis-, and mono-phosphates and decreases in PtdIns(4,5)P2, phosphatidylinositol 4-phosphate, and phosphatidylinositol within 5 min after addition to the cytotoxin-treated cells at 37 C. GTP gamma S stimulated, to some extent, polyphosphoinositide hydrolysis in the cytotoxin-treated JURKAT.	inositol tris-, bis-, and mono-phosphates	36-77	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2839752-5	1988	NaF plus AlCl3 induced increases in inositol tris-, bis-, and mono-phosphates and decreases in PtdIns(4,5)P2, phosphatidylinositol 4-phosphate, and phosphatidylinositol within 5 min after addition to the cytotoxin-treated cells at 37 C. GTP gamma S stimulated, to some extent, polyphosphoinositide hydrolysis in the cytotoxin-treated JURKAT.	Phosphatidylinositol 4,5-Diphosphate	95-108	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2839752-5	1988	NaF plus AlCl3 induced increases in inositol tris-, bis-, and mono-phosphates and decreases in PtdIns(4,5)P2, phosphatidylinositol 4-phosphate, and phosphatidylinositol within 5 min after addition to the cytotoxin-treated cells at 37 C. GTP gamma S stimulated, to some extent, polyphosphoinositide hydrolysis in the cytotoxin-treated JURKAT.	phosphatidylinositol 4-phosphate	110-142	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2839752-5	1988	NaF plus AlCl3 induced increases in inositol tris-, bis-, and mono-phosphates and decreases in PtdIns(4,5)P2, phosphatidylinositol 4-phosphate, and phosphatidylinositol within 5 min after addition to the cytotoxin-treated cells at 37 C. GTP gamma S stimulated, to some extent, polyphosphoinositide hydrolysis in the cytotoxin-treated JURKAT.	Phosphatidylinositols	110-130	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2839752-5	1988	NaF plus AlCl3 induced increases in inositol tris-, bis-, and mono-phosphates and decreases in PtdIns(4,5)P2, phosphatidylinositol 4-phosphate, and phosphatidylinositol within 5 min after addition to the cytotoxin-treated cells at 37 C. GTP gamma S stimulated, to some extent, polyphosphoinositide hydrolysis in the cytotoxin-treated JURKAT.	Guanosine Triphosphate	237-240	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2839752-5	1988	NaF plus AlCl3 induced increases in inositol tris-, bis-, and mono-phosphates and decreases in PtdIns(4,5)P2, phosphatidylinositol 4-phosphate, and phosphatidylinositol within 5 min after addition to the cytotoxin-treated cells at 37 C. GTP gamma S stimulated, to some extent, polyphosphoinositide hydrolysis in the cytotoxin-treated JURKAT.	Phosphatidylinositol Phosphates	277-297	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
3322281-4	1987	Crude and pure NAF stimulated human neutrophils to release granule enzymes and to produce superoxide and H2O2.	Superoxides	90-100	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
3322281-4	1987	Crude and pure NAF stimulated human neutrophils to release granule enzymes and to produce superoxide and H2O2.	Hydrogen Peroxide	105-109	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
2824608-1	1987	A novel monocyte-derived neutrophil-activating peptide (MONAP) produced by lipopolysaccharide- and phorbol myristate acetate-stimulated human peripheral blood monocytes was purified by sequential ion exchange-high performance liquid chromatography (HPLC), size exclusion HPLC, and reversed phase HPLC.	Tetradecanoylphorbol Acetate	99-124	C-X-C motif chemokine ligand 8	Homo sapiens	56-61
2824608-3	1987	Purified MONAP was found to be homogeneous, giving a single peak on size-exclusion HPLC, reversed-phase HPLC, as well as a single 10-kDa band on silver-stained polyacrylamide gels.	polyacrylamide	160-174	C-X-C motif chemokine ligand 8	Homo sapiens	9-14
2824608-4	1987	Purified MONAP stimulate human neutrophil chemotaxis at an estimated molarity of 5 x 10(-11) M. Half-maximal enzyme release of cytochalasin B pretreated neutrophils occurred at 2 to 3 x 10(-10) M, whereas superoxide anion production elicited by various concentrations of MONAP was found to be low.	Cytochalasin B	127-141	C-X-C motif chemokine ligand 8	Homo sapiens	9-14
2824608-4	1987	Purified MONAP stimulate human neutrophil chemotaxis at an estimated molarity of 5 x 10(-11) M. Half-maximal enzyme release of cytochalasin B pretreated neutrophils occurred at 2 to 3 x 10(-10) M, whereas superoxide anion production elicited by various concentrations of MONAP was found to be low.	Cytochalasin B	127-141	C-X-C motif chemokine ligand 8	Homo sapiens	271-276
3120720-4	1987	Moreover, the dose-response effects of NaF on arachidonate release and DG formation were different.	Arachidonic Acid	46-58	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
2824608-4	1987	Purified MONAP stimulate human neutrophil chemotaxis at an estimated molarity of 5 x 10(-11) M. Half-maximal enzyme release of cytochalasin B pretreated neutrophils occurred at 2 to 3 x 10(-10) M, whereas superoxide anion production elicited by various concentrations of MONAP was found to be low.	Superoxides	205-221	C-X-C motif chemokine ligand 8	Homo sapiens	9-14
3429387-3	1987	Elimination of O2-dependent antimicrobial systems with retention of phagocytic activity was achieved by using polymorphs from children with chronic granulomatous disease NaF-pulsed normal polymorphs.	Oxygen	15-17	C-X-C motif chemokine ligand 8	Homo sapiens	170-173
2825101-6	1987	In addition, the corticosteroidogenic effect of forskolin and NaF (which respectively stimulate the adenylate-cyclase subunit and the guanyl nucleotide regularly protein) was not affected by vinblastine.	guanyl nucleotide	134-151	C-X-C motif chemokine ligand 8	Homo sapiens	62-65
10872408-1	1987	The purpose of this investigation was to examine the potential genotoxic influence of sodium fluoride (NaF) on mammalian cells by means of a mouse bone-marrow micronucleus test.	Sodium Fluoride	86-101	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
10872408-8	1987	The results indicated that doses of NaF up to the MTD did not significantly increase the frequencies of MN-PCE when compared with the negative controls, although the bone fluoride content increased as the dose of NaF was increased.	Fluorides	171-179	C-X-C motif chemokine ligand 8	Homo sapiens	213-216
2825667-2	1987	NAF also induced the generation of 5(S),12(R)-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid [Leukotriene B4 (LTB4)] by PMNs which was enhanced in the presence of exogenous arachidonic acid (AA).	5(s),12(r)-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid	35-97	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2825667-2	1987	NAF also induced the generation of 5(S),12(R)-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid [Leukotriene B4 (LTB4)] by PMNs which was enhanced in the presence of exogenous arachidonic acid (AA).	Leukotriene B4	99-113	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2825667-2	1987	NAF also induced the generation of 5(S),12(R)-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid [Leukotriene B4 (LTB4)] by PMNs which was enhanced in the presence of exogenous arachidonic acid (AA).	Leukotriene B4	115-119	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2825667-2	1987	NAF also induced the generation of 5(S),12(R)-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid [Leukotriene B4 (LTB4)] by PMNs which was enhanced in the presence of exogenous arachidonic acid (AA).	Arachidonic Acid	178-194	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2825667-4	1987	15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid (15-HETE), a product of the 15-lipoxy-genation of AA in PMNS, caused a concentration-dependent suppression of degranulation and LTB4 generation by PMNs in contact with NAF.	15(s)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid	0-55	C-X-C motif chemokine ligand 8	Homo sapiens	224-227
2825667-4	1987	15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid (15-HETE), a product of the 15-lipoxy-genation of AA in PMNS, caused a concentration-dependent suppression of degranulation and LTB4 generation by PMNs in contact with NAF.	15-Hete	57-64	C-X-C motif chemokine ligand 8	Homo sapiens	224-227
2825667-5	1987	15-HETE also inhibited the rise in cytosolic-free calcium [( Ca2+]i) observed in NAF activated PMNs.	15-Hete	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
2825667-5	1987	15-HETE also inhibited the rise in cytosolic-free calcium [( Ca2+]i) observed in NAF activated PMNs.	Calcium	50-57	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
3114629-3	1987	Sodium fluoride (NaF) has previously been shown to be clastogenic in vitro in Syrian hamster cells and human fibroblasts.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
3114629-8	1987	(2) NaCl is weakly clastogenic at 1000 times the threshold dose for NaF.	Sodium Chloride	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
3038870-7	1987	The same holds true for NaF and guanosine 5"-(beta, gamma-imido)trisphosphate, indicating a constant activity of the guanine nucleotide regulatory unit which mediates hormonal stimulation of adenylate cyclase (Ns).	Guanine Nucleotides	117-135	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
3657146-1	1987	Desmethylnafoxidine aziridine (Naf-Az), an affinity label for the estrogen receptor based structurally on the antiestrogen nafoxidine, has been prepared in unlabeled and in high specific activity, tritium-labeled form and has been evaluated for its apparent competitive binding, and time-dependent irreversible, covalent attachment to the estrogen receptor.	desmethylnafoxidine aziridine	0-29	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
3657146-1	1987	Desmethylnafoxidine aziridine (Naf-Az), an affinity label for the estrogen receptor based structurally on the antiestrogen nafoxidine, has been prepared in unlabeled and in high specific activity, tritium-labeled form and has been evaluated for its apparent competitive binding, and time-dependent irreversible, covalent attachment to the estrogen receptor.	Nafoxidine	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
3657146-1	1987	Desmethylnafoxidine aziridine (Naf-Az), an affinity label for the estrogen receptor based structurally on the antiestrogen nafoxidine, has been prepared in unlabeled and in high specific activity, tritium-labeled form and has been evaluated for its apparent competitive binding, and time-dependent irreversible, covalent attachment to the estrogen receptor.	Tritium	197-204	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
3657146-2	1987	Naf-Az was synthesized through a key 1,2-diaryl-3,4-dihydronaphthalene intermediate that was prepared from 6-methoxy-1-tetralone by two routes involving alternate strategies for arylation.	1,2-diaryl-3,4-dihydronaphthalene	37-70	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
3657146-2	1987	Naf-Az was synthesized through a key 1,2-diaryl-3,4-dihydronaphthalene intermediate that was prepared from 6-methoxy-1-tetralone by two routes involving alternate strategies for arylation.	6-Methoxy-1-tetralone	107-128	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
3657146-3	1987	Conversion of the diaryldihydronaphthalene to Naf-Az through a series of deprotection-activation reactions culminated in ethyleneimine displacement of a methanesulfonate.	diaryldihydronaphthalene	18-42	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
3657146-3	1987	Conversion of the diaryldihydronaphthalene to Naf-Az through a series of deprotection-activation reactions culminated in ethyleneimine displacement of a methanesulfonate.	aziridine	121-134	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
3657146-3	1987	Conversion of the diaryldihydronaphthalene to Naf-Az through a series of deprotection-activation reactions culminated in ethyleneimine displacement of a methanesulfonate.	methanesulfonic acid	153-169	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
3657146-5	1987	Compared to our previously-prepared reagent tamoxifen aziridine (Tam-Az), Naf-Az has a higher apparent competitive binding affinity, and it reacts with the estrogen receptor in cytosol preparations and in intact MCF-7 breast cancer cells rapidly and with at least comparable efficiency and selectivity.	Tamoxifen	44-53	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
3657146-5	1987	Compared to our previously-prepared reagent tamoxifen aziridine (Tam-Az), Naf-Az has a higher apparent competitive binding affinity, and it reacts with the estrogen receptor in cytosol preparations and in intact MCF-7 breast cancer cells rapidly and with at least comparable efficiency and selectivity.	aziridine	54-63	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
3657146-5	1987	Compared to our previously-prepared reagent tamoxifen aziridine (Tam-Az), Naf-Az has a higher apparent competitive binding affinity, and it reacts with the estrogen receptor in cytosol preparations and in intact MCF-7 breast cancer cells rapidly and with at least comparable efficiency and selectivity.	tamoxifen aziridine	65-71	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
3028538-2	1987	At lower concentrations, with a peak activity between 30 and 40 mmol/L, NaF induced aggregation and release of adenosine 5"-triphosphate (ATP) that was associated with increased formation of inositol phosphates, a rise in cytosolic free Ca2+, and phosphorylation of 20-kd and 40-kd proteins.	Adenosine Triphosphate	111-136	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
3111669-1	1987	Daily treatment with 30 mg of sodium fluoride (NaF) and 1 g of calcium over a 3-year period increased the bone mineral content (BMC) in the spines of women (n = 25) with osteoporosis.	Sodium Fluoride	30-45	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
2882783-3	1987	Human but not bovine serum albumin in the presence of NaF abolished activation of heme-containing guanylate cyclase by NO and nitroso compounds, whereas enzyme activation by arachidonic acid was markedly enhanced.	Nitroso Compounds	126-143	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
2885225-2	1987	The formation of inositol bis- and trisphosphates was stimulated in a buffer with 110 nM free Ca2+ with a nonhydrolyzable GTP analogue, GTP gamma S, and NaF plus AlCl3 in a time- and concentration-dependent manner.	inositol bis- and trisphosphates	17-49	C-X-C motif chemokine ligand 8	Homo sapiens	153-156
2885225-4	1987	AlCl3 enhanced the NaF-stimulated release of inositol polyphosphates.	Aluminum Chloride	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
2885225-4	1987	AlCl3 enhanced the NaF-stimulated release of inositol polyphosphates.	inositol polyphosphates	45-68	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
2885225-5	1987	Optimum concentrations of NaF and AlCl3 produced 1.5-fold more inositol polyphosphates than that produced by optimum concentration of GTP gamma S. OKT3 monoclonal antibody, an antibody against the T-cell receptor complex, did not stimulate the inositol polyphosphate formation by JURKAT membranes even in the presence of GTP, although the antibody at the concentrations used markedly stimulated the hydrolysis of polyphosphoinositides in intact JURKAT cells.	inositol polyphosphates	63-86	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
2885225-5	1987	Optimum concentrations of NaF and AlCl3 produced 1.5-fold more inositol polyphosphates than that produced by optimum concentration of GTP gamma S. OKT3 monoclonal antibody, an antibody against the T-cell receptor complex, did not stimulate the inositol polyphosphate formation by JURKAT membranes even in the presence of GTP, although the antibody at the concentrations used markedly stimulated the hydrolysis of polyphosphoinositides in intact JURKAT cells.	Phytic Acid	63-85	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
2885225-5	1987	Optimum concentrations of NaF and AlCl3 produced 1.5-fold more inositol polyphosphates than that produced by optimum concentration of GTP gamma S. OKT3 monoclonal antibody, an antibody against the T-cell receptor complex, did not stimulate the inositol polyphosphate formation by JURKAT membranes even in the presence of GTP, although the antibody at the concentrations used markedly stimulated the hydrolysis of polyphosphoinositides in intact JURKAT cells.	Guanosine Triphosphate	321-324	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
2885225-5	1987	Optimum concentrations of NaF and AlCl3 produced 1.5-fold more inositol polyphosphates than that produced by optimum concentration of GTP gamma S. OKT3 monoclonal antibody, an antibody against the T-cell receptor complex, did not stimulate the inositol polyphosphate formation by JURKAT membranes even in the presence of GTP, although the antibody at the concentrations used markedly stimulated the hydrolysis of polyphosphoinositides in intact JURKAT cells.	Phosphatidylinositol Phosphates	413-434	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
3032933-3	1987	PtdIns-P2 phospholipase C was also activated by nucleoside triphosphates, citrate, EDTA, and NaF.	Phosphatidylinositol 4,5-Diphosphate	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
3028538-2	1987	At lower concentrations, with a peak activity between 30 and 40 mmol/L, NaF induced aggregation and release of adenosine 5"-triphosphate (ATP) that was associated with increased formation of inositol phosphates, a rise in cytosolic free Ca2+, and phosphorylation of 20-kd and 40-kd proteins.	Adenosine Triphosphate	138-141	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
3028538-2	1987	At lower concentrations, with a peak activity between 30 and 40 mmol/L, NaF induced aggregation and release of adenosine 5"-triphosphate (ATP) that was associated with increased formation of inositol phosphates, a rise in cytosolic free Ca2+, and phosphorylation of 20-kd and 40-kd proteins.	Inositol Phosphates	191-210	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
2436701-2	1987	Results are presented which show that prolonged incubation of platelets with iloprost (a stable prostacyclin analogue) results in a reduction in the capacity for adenylate cyclase activation by the adenosine analogue 5"-(N-ethyl)-carboxamidoadenosine (NECA), NaF, guanyl-5"-yl imidodiphosphate or GTP.	Epoprostenol	96-108	C-X-C motif chemokine ligand 8	Homo sapiens	259-262
3028538-3	1987	At NaF concentrations greater than 40 mmol/L, aggregation and ATP release decreased dose-dependently in parallel with a decrease in Ca2+ mobilization, whereas neither inositol phosphate formation nor 40-kd protein phosphorylation was reduced.	Adenosine Triphosphate	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	3-6
3028538-4	1987	At these concentrations, NaF caused a dose-dependent transient rise in platelet cyclic adenosine 3",5"-monophosphate (cAMP) levels that was sufficient to account for the observed reduction in Ca2+ mobilization, aggregation, and ATP release.	Cyclic AMP	80-116	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
2436701-2	1987	Results are presented which show that prolonged incubation of platelets with iloprost (a stable prostacyclin analogue) results in a reduction in the capacity for adenylate cyclase activation by the adenosine analogue 5"-(N-ethyl)-carboxamidoadenosine (NECA), NaF, guanyl-5"-yl imidodiphosphate or GTP.	Iloprost	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	259-262
3028538-4	1987	At these concentrations, NaF caused a dose-dependent transient rise in platelet cyclic adenosine 3",5"-monophosphate (cAMP) levels that was sufficient to account for the observed reduction in Ca2+ mobilization, aggregation, and ATP release.	Cyclic AMP	118-122	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
3028538-4	1987	At these concentrations, NaF caused a dose-dependent transient rise in platelet cyclic adenosine 3",5"-monophosphate (cAMP) levels that was sufficient to account for the observed reduction in Ca2+ mobilization, aggregation, and ATP release.	Adenosine Triphosphate	228-231	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
3028538-5	1987	Stimulated cAMP levels started declining rapidly within 30 seconds of addition of NaF, however.	Cyclic AMP	11-15	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
3028538-6	1987	Similarly, prostacyclin (PGI2)-induced cAMP accumulation was temporarily enhanced but subsequently suppressed by NaF, suggesting either stimulation of a cAMP phosphodiesterase or delayed inhibition of adenylate cyclase.	Epoprostenol	11-23	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
3028538-6	1987	Similarly, prostacyclin (PGI2)-induced cAMP accumulation was temporarily enhanced but subsequently suppressed by NaF, suggesting either stimulation of a cAMP phosphodiesterase or delayed inhibition of adenylate cyclase.	Epoprostenol	25-29	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
3028538-7	1987	Evidence for the latter was provided by the finding that NaF pretreatment of platelets resulted in partial inhibition of PGI2-stimulated cAMP formation in the presence of the cAMP phosphodiesterase inhibitor 3-isobutyl-1-methyl-xanthine (MIX).	Epoprostenol	121-125	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
3028538-7	1987	Evidence for the latter was provided by the finding that NaF pretreatment of platelets resulted in partial inhibition of PGI2-stimulated cAMP formation in the presence of the cAMP phosphodiesterase inhibitor 3-isobutyl-1-methyl-xanthine (MIX).	Cyclic AMP	137-141	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
3028538-7	1987	Evidence for the latter was provided by the finding that NaF pretreatment of platelets resulted in partial inhibition of PGI2-stimulated cAMP formation in the presence of the cAMP phosphodiesterase inhibitor 3-isobutyl-1-methyl-xanthine (MIX).	1-Methyl-3-isobutylxanthine	208-236	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
3453041-7	1987	NaF, an activator of adenylate cyclase, like adrenaline, stimulated the incorporation of linoleic acid into ghost membrane phospholipids.	Epinephrine	45-55	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
3550448-1	1987	The mutagenicity of fluoride (as sodium fluoride, NaF) was investigated with Ames Salmonella/microsome assays in strains of TA97a, TA98, TA100, TA102 and TA1535.	Fluorides	20-28	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
3453041-7	1987	NaF, an activator of adenylate cyclase, like adrenaline, stimulated the incorporation of linoleic acid into ghost membrane phospholipids.	Linoleic Acid	89-102	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
3453041-7	1987	NaF, an activator of adenylate cyclase, like adrenaline, stimulated the incorporation of linoleic acid into ghost membrane phospholipids.	Phospholipids	123-136	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
3800973-8	1986	Millimolar concentrations of NaF also stimulated the formation of inositol phosphates in membrane preparations from 1321N1 cells.	Inositol Phosphates	66-85	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
3463564-3	1986	The Bmax for [3H]forskolin binding is increased to 455 and 425 fmol/mg of protein in the presence of 100 microM guanyl-5"-yl imidodiphosphate (Gpp(NH)p) and 10 mM NaF, respectively.	Tritium	14-16	C-X-C motif chemokine ligand 8	Homo sapiens	163-166
3463564-3	1986	The Bmax for [3H]forskolin binding is increased to 455 and 425 fmol/mg of protein in the presence of 100 microM guanyl-5"-yl imidodiphosphate (Gpp(NH)p) and 10 mM NaF, respectively.	Colforsin	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	163-166
3463564-4	1986	The increase in the Bmax for [3H]forskolin in the presence of Gpp(NH)p or NaF is not observed in the absence of MgCl2.	Tritium	30-32	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
3463564-4	1986	The increase in the Bmax for [3H]forskolin in the presence of Gpp(NH)p or NaF is not observed in the absence of MgCl2.	Colforsin	33-42	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
3463564-5	1986	The EC50 values for the increase in the number of binding sites for [3H]forskolin by Gpp(NH)p and NaF are 600 nM and 4 mM, respectively.	Tritium	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	98-101
3463564-5	1986	The EC50 values for the increase in the number of binding sites for [3H]forskolin by Gpp(NH)p and NaF are 600 nM and 4 mM, respectively.	Colforsin	72-81	C-X-C motif chemokine ligand 8	Homo sapiens	98-101
3463564-7	1986	The increase in the number of [3H]forskolin binding sites observed in the presence of NaF is unaffected by prostaglandins.	Tritium	31-33	C-X-C motif chemokine ligand 8	Homo sapiens	86-89
3463564-7	1986	The increase in the number of [3H]forskolin binding sites observed in the presence of NaF is unaffected by prostaglandins.	Colforsin	34-43	C-X-C motif chemokine ligand 8	Homo sapiens	86-89
3435503-6	1987	Highly purified sarcolemmal membranes, exhibiting an NaF-stimulated activity of 3.46 +/- 0.65 nmol cAMP formed min-1 mg-1 of protein, were exposed to free radicals formation of which was induced by Fe++/ascorbate.	Cyclic AMP	99-103	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
3435503-6	1987	Highly purified sarcolemmal membranes, exhibiting an NaF-stimulated activity of 3.46 +/- 0.65 nmol cAMP formed min-1 mg-1 of protein, were exposed to free radicals formation of which was induced by Fe++/ascorbate.	Iron	198-202	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
3435503-6	1987	Highly purified sarcolemmal membranes, exhibiting an NaF-stimulated activity of 3.46 +/- 0.65 nmol cAMP formed min-1 mg-1 of protein, were exposed to free radicals formation of which was induced by Fe++/ascorbate.	Ascorbic Acid	203-212	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
16665178-10	1986	When 0.3 millimolar PEP either alone or with 0.1 millimolar ATP and 0.3 millimolar NaF is present during preincubation, the effect of malate in a following assay is to activate the reaction.	malic acid	134-140	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
3762571-1	1986	Sodium fluoride (NaF) was assayed for the induction of DNA-repair synthesis in WI-38 human diploid fibroblasts and in primary cultures of rat hepatocytes.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
3743666-3	1986	The lysosomotropic agents conA, NaF, eserine and atropine have two parallel effects on resting lymphocytes, after they have endocytosed [3H]NHP: inhibition of degradation and increased translocation of [3H]NHP from the cytoplasm to the nucleus.	Tritium	137-139	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
3743666-3	1986	The lysosomotropic agents conA, NaF, eserine and atropine have two parallel effects on resting lymphocytes, after they have endocytosed [3H]NHP: inhibition of degradation and increased translocation of [3H]NHP from the cytoplasm to the nucleus.	Tritium	203-205	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
3762571-7	1986	Published reports (Hellung-Larsen and Klenow, 1969; Srivastava et al., 1981) describe the formation of precipitable complexes of Mg2+, F-, and [3H]thymidine triphosphate which suggests that autoradiographic measurement of UDS may lead to artifacts when testing NaF unless extensive washing of the cultures is employed.	magnesium ion	129-133	C-X-C motif chemokine ligand 8	Homo sapiens	261-264
3762571-7	1986	Published reports (Hellung-Larsen and Klenow, 1969; Srivastava et al., 1981) describe the formation of precipitable complexes of Mg2+, F-, and [3H]thymidine triphosphate which suggests that autoradiographic measurement of UDS may lead to artifacts when testing NaF unless extensive washing of the cultures is employed.	Tritium	144-146	C-X-C motif chemokine ligand 8	Homo sapiens	261-264
3762571-7	1986	Published reports (Hellung-Larsen and Klenow, 1969; Srivastava et al., 1981) describe the formation of precipitable complexes of Mg2+, F-, and [3H]thymidine triphosphate which suggests that autoradiographic measurement of UDS may lead to artifacts when testing NaF unless extensive washing of the cultures is employed.	thymidine 5'-triphosphate	147-169	C-X-C motif chemokine ligand 8	Homo sapiens	261-264
3015678-1	1986	Partially purified plasma membranes prepared from myo-[3H]inositol-prelabeled WRK1 cells exhibit a phosphatidylinositol 4,5-biphosphate (PIP2) phospholipase C activity sensitive to NaF.	myo-[3h]inositol	50-66	C-X-C motif chemokine ligand 8	Homo sapiens	181-184
3747724-1	1986	Low, micromolar concentrations of aluminum (in the presence of NaF) were shown to strongly activate human platelet adenylate cyclase and provided a useful probe for evaluating cyclic AMP second messenger function distal to the receptor: The effect of normal aging and disease state on second messenger activity in man was studied by measurements of the aluminum-activated enzyme.	Aluminum	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
3747724-1	1986	Low, micromolar concentrations of aluminum (in the presence of NaF) were shown to strongly activate human platelet adenylate cyclase and provided a useful probe for evaluating cyclic AMP second messenger function distal to the receptor: The effect of normal aging and disease state on second messenger activity in man was studied by measurements of the aluminum-activated enzyme.	Cyclic AMP	176-186	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
3747724-1	1986	Low, micromolar concentrations of aluminum (in the presence of NaF) were shown to strongly activate human platelet adenylate cyclase and provided a useful probe for evaluating cyclic AMP second messenger function distal to the receptor: The effect of normal aging and disease state on second messenger activity in man was studied by measurements of the aluminum-activated enzyme.	Aluminum	353-361	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
3747724-3	1986	An age-associated decline in NaF-stimulated cyclic AMP synthesis was also demonstrated for normal, non-demented subjects.	Cyclic AMP	44-54	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
3015678-1	1986	Partially purified plasma membranes prepared from myo-[3H]inositol-prelabeled WRK1 cells exhibit a phosphatidylinositol 4,5-biphosphate (PIP2) phospholipase C activity sensitive to NaF.	Phosphatidylinositol 4,5-Diphosphate	99-135	C-X-C motif chemokine ligand 8	Homo sapiens	181-184
3015678-1	1986	Partially purified plasma membranes prepared from myo-[3H]inositol-prelabeled WRK1 cells exhibit a phosphatidylinositol 4,5-biphosphate (PIP2) phospholipase C activity sensitive to NaF.	Phosphatidylinositol 4,5-Diphosphate	137-141	C-X-C motif chemokine ligand 8	Homo sapiens	181-184
3015678-2	1986	NaF increased the production of IP2 and IP3 in a time- and concentration-dependent manner.	Inositol 1,4,5-Trisphosphate	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
3950443-3	1986	Neutralization of O2-dependent antimicrobial systems with retention of phagocytic capacity was achieved with use of PMNLs from four children with chronic granulomatous disease (CGD) or NaF-pulsed normal PMNLs.	Oxygen	18-20	C-X-C motif chemokine ligand 8	Homo sapiens	185-188
3085731-6	1986	Mitochondrial inhibitors (KCN, NaN3, antimycin A, FCCP and dinitrophenol) inhibited the potential oscillation, whereas glycolytic inhibitors (iodoacetic acid and NaF) had no effects.	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	50-54	C-X-C motif chemokine ligand 8	Homo sapiens	162-165
3028102-0	1986	On the role of guanine nucleotide binding regulatory proteins (G-proteins) in signal transduction in human platelets: studies with sodium fluoride (NaF).	Sodium Fluoride	131-146	C-X-C motif chemokine ligand 8	Homo sapiens	148-151
3010521-2	1986	Gpp(NH)p and NaF are shown to be tightly bound to GTP-binding proteins (G-proteins) of outer segments of optic rods, additional activation of phosphodiesterase in the presence of Gpp(NH)p being observed after preincubation with NaF and subsequent washing of the membrane.	Guanylyl Imidodiphosphate	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	228-231
3010521-2	1986	Gpp(NH)p and NaF are shown to be tightly bound to GTP-binding proteins (G-proteins) of outer segments of optic rods, additional activation of phosphodiesterase in the presence of Gpp(NH)p being observed after preincubation with NaF and subsequent washing of the membrane.	Guanosine Triphosphate	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
3010521-2	1986	Gpp(NH)p and NaF are shown to be tightly bound to GTP-binding proteins (G-proteins) of outer segments of optic rods, additional activation of phosphodiesterase in the presence of Gpp(NH)p being observed after preincubation with NaF and subsequent washing of the membrane.	Guanylyl Imidodiphosphate	179-187	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
3010521-4	1986	It is found that (NH4)2SO4 does not affect the basal activity of phosphodiesterase but inhibits the activating effect of Gpp(NH)p and NaF on the enzyme.	Ammonium Sulfate	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	134-137
3010521-6	1986	Changes in the concentration of Mg2+ in the medium influence insignificantly the basal activity of phosphodiesterase but are necessary for manifestation of the activating effect of Gpp(NH)p and NaF.	magnesium ion	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	194-197
3085668-1	1986	Addition of NaF to washed platelets produces a dose-dependent and transient elevation of the intracellular free calcium concentration ([Ca++]i), thromboxane B2 (TxB2) generation and dense granule release, all of which are significantly inhibited when the extracellular calcium concentration ([Ca++]e) is reduced with EGTA.	Calcium	112-119	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
3085668-1	1986	Addition of NaF to washed platelets produces a dose-dependent and transient elevation of the intracellular free calcium concentration ([Ca++]i), thromboxane B2 (TxB2) generation and dense granule release, all of which are significantly inhibited when the extracellular calcium concentration ([Ca++]e) is reduced with EGTA.	Thromboxane B2	145-159	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
3085668-1	1986	Addition of NaF to washed platelets produces a dose-dependent and transient elevation of the intracellular free calcium concentration ([Ca++]i), thromboxane B2 (TxB2) generation and dense granule release, all of which are significantly inhibited when the extracellular calcium concentration ([Ca++]e) is reduced with EGTA.	Calcium	269-276	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
3085668-1	1986	Addition of NaF to washed platelets produces a dose-dependent and transient elevation of the intracellular free calcium concentration ([Ca++]i), thromboxane B2 (TxB2) generation and dense granule release, all of which are significantly inhibited when the extracellular calcium concentration ([Ca++]e) is reduced with EGTA.	Egtazic Acid	317-321	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
3085668-4	1986	Pretreatment of the platelets with the selective protein kinase C inhibitor H7 prevents TPA induced inhibition of NaF mediated rise in [Ca++]i and TxB2 generation.	Tetradecanoylphorbol Acetate	88-91	C-X-C motif chemokine ligand 8	Homo sapiens	114-117
3085668-5	1986	Thus we propose that NaF induced calcium mobilisation is analogous to receptor-operated calcium mobilisation in platelets, as it is readily inhibited by protein kinase C activation or by the reduction of [Ca++]e and is independent of platelet cyclo-oxygenase activity.	Calcium	33-40	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
3085668-5	1986	Thus we propose that NaF induced calcium mobilisation is analogous to receptor-operated calcium mobilisation in platelets, as it is readily inhibited by protein kinase C activation or by the reduction of [Ca++]e and is independent of platelet cyclo-oxygenase activity.	Calcium	88-95	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
3001042-2	1986	At millimolar concentrations, reagent grade NaF inhibited glucose-6-P hydrolysis and protected the enzyme against inactivation induced by heat in the presence of 0.025% (w/v) Triton X-100 or by reaction of the catalytic site with the histidine-specific reagent, diethyl pyrocarbonate.	Histidine	234-243	C-X-C motif chemokine ligand 8	Homo sapiens	44-47
3001042-2	1986	At millimolar concentrations, reagent grade NaF inhibited glucose-6-P hydrolysis and protected the enzyme against inactivation induced by heat in the presence of 0.025% (w/v) Triton X-100 or by reaction of the catalytic site with the histidine-specific reagent, diethyl pyrocarbonate.	Diethyl Pyrocarbonate	262-283	C-X-C motif chemokine ligand 8	Homo sapiens	44-47
3001042-3	1986	The presence of millimolar EDTA in all test systems abolished the effectiveness of NaF, yet EDTA by itself was without significant influence on the kinetics of phosphohydrolase reaction, the thermal stability of the enzyme or its reactivity with diethyl pyrocarbonate.	Edetic Acid	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
3001042-4	1986	Although ultrapure NaF was ineffectual in all test systems, its potency as a competitive inhibitor or protective agent was markedly increased by micromolar AlCl3 or when assays were carried out in flint glass test tubes.	Aluminum Chloride	156-161	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
3768209-5	1986	Fourteen-day-old chicks treated with NaF (4.2 mM NaF in the drinking water) for 2 weeks showed increases in bone-forming surface in the tibial metaphysis (130% of untreated controls, P less than 0.002), with no change in the number of osteoblasts per length of forming surface (104% of control).	Drinking Water	60-74	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
3768198-1	1986	The benefit of sodium fluoride (NaF) in the therapy of osteoporosis is still controversial.	Sodium Fluoride	15-30	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
3768209-1	1986	Sodium fluoride (NaF) is the single most effective agent for increasing bone volume in the osteoporotic skeleton.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
3768209-6	1986	The NaF dose dependence of the change in bone-forming surface was biphasic, being optimal at 23 microM fluoride.	Fluorides	103-111	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
3768209-5	1986	Fourteen-day-old chicks treated with NaF (4.2 mM NaF in the drinking water) for 2 weeks showed increases in bone-forming surface in the tibial metaphysis (130% of untreated controls, P less than 0.002), with no change in the number of osteoblasts per length of forming surface (104% of control).	Drinking Water	60-74	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
3768209-7	1986	Linear correlations were observed between dietary NaF and serum fluoride (r = 0.996, P less than 0.001), and serum fluoride and bone fluoride concentrations (r = 0.98, P less than 0.001).	Fluorides	64-72	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
3793326-8	1986	Clofazimine is not an oxidising agent nor did it stimulate membrane-associated oxidative metabolism in CGD or NaF-pulsed normal PMNL.	Clofazimine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	110-113
3013404-0	1986	Fluoride uptake from an anti-calculus NaF dentifrice in vitro.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
3457629-3	1986	A carboxylic esterase isoenzyme which can be inhibited completely and selectively by sodium fluoride (NaF) was demonstrated by isoelectric focusing on horizontal polyacrylamide gels.	Sodium Fluoride	85-100	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
3457629-3	1986	A carboxylic esterase isoenzyme which can be inhibited completely and selectively by sodium fluoride (NaF) was demonstrated by isoelectric focusing on horizontal polyacrylamide gels.	polyacrylamide	162-176	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
3025924-10	1986	Human adenylate cyclase obtained from platelets and lymphocytes is activated by micromolar amounts of aluminum in the presence of NaF.	Aluminum	102-110	C-X-C motif chemokine ligand 8	Homo sapiens	130-133
3868620-3	1985	One isoenzyme consisting of one or two components (bands) could be completely and selectively inhibited by addition of 40 mM sodium fluoride (NaF) to the staining bath.	Sodium Fluoride	125-140	C-X-C motif chemokine ligand 8	Homo sapiens	142-145
4092416-1	1985	In sixteen patients subjected to intestinal surgery, the transport of sodium fluorescein (Na-F) was measured between the mucosal and serosal-muscular layers.	Fluorescein	70-88	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
2933233-2	1985	Fluorescein flowmetry implies the measurement of capillary blood flow, expressed as an index between the maximum fluorescence after the first circulatory passage of sodium fluorescein (NaF) and the rise time, defined as the time interval between ten and 90 percent of the maximum fluorescence.	Fluorescein	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	185-188
2933233-2	1985	Fluorescein flowmetry implies the measurement of capillary blood flow, expressed as an index between the maximum fluorescence after the first circulatory passage of sodium fluorescein (NaF) and the rise time, defined as the time interval between ten and 90 percent of the maximum fluorescence.	Fluorescein	165-183	C-X-C motif chemokine ligand 8	Homo sapiens	185-188
2997209-2	1985	Treatment of isolated hepatocytes with NaF produced a concentration-dependent activation of phosphorylase, inactivation of glycogen synthase, efflux of Ca2+, rise in cytosolic free Ca2+ ([Ca2+]i), increase in myo-inositol-1,4,5,-P3 levels, decrease in phosphatidylinositol-4,5-P2 levels, and increase in 1,2-diacylglycerol levels.	myo-inositol-1,4,5,-p3	209-231	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
2997209-6	1985	The effects of low doses of NaF (2-15 mM) to inhibit basal or glucagon-stimulated cAMP accumulation, mobilize Ca2+, activate phosphorylase, and inactivate glycogen synthase were all potentiated by AlCl3.	Aluminum Chloride	197-202	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
2997209-6	1985	The effects of low doses of NaF (2-15 mM) to inhibit basal or glucagon-stimulated cAMP accumulation, mobilize Ca2+, activate phosphorylase, and inactivate glycogen synthase were all potentiated by AlCl3.	Cyclic AMP	82-86	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
2997209-2	1985	Treatment of isolated hepatocytes with NaF produced a concentration-dependent activation of phosphorylase, inactivation of glycogen synthase, efflux of Ca2+, rise in cytosolic free Ca2+ ([Ca2+]i), increase in myo-inositol-1,4,5,-P3 levels, decrease in phosphatidylinositol-4,5-P2 levels, and increase in 1,2-diacylglycerol levels.	phosphatidylinositol-4,5-p2	252-279	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
2997209-2	1985	Treatment of isolated hepatocytes with NaF produced a concentration-dependent activation of phosphorylase, inactivation of glycogen synthase, efflux of Ca2+, rise in cytosolic free Ca2+ ([Ca2+]i), increase in myo-inositol-1,4,5,-P3 levels, decrease in phosphatidylinositol-4,5-P2 levels, and increase in 1,2-diacylglycerol levels.	1,2-diacylglycerol	304-322	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
2997209-4	1985	Maximum effects on Ca2+ efflux, [Ca2+]i, glycogen synthase, and phosphorylase were observed with 15 mM NaF, whereas myo-inositol-1,4,5-P3 and 1,2-diacylglycerol levels were maximally stimulated by 50 mM NaF.	1,2-diacylglycerol	142-160	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
2997209-5	1985	The levels of intracellular cAMP were decreased by NaF (up to 10 mM) in the absence or presence of glucagon (0.1-1 nM) or forskolin (2 microM).	Cyclic AMP	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
2997209-6	1985	The effects of low doses of NaF (2-15 mM) to inhibit basal or glucagon-stimulated cAMP accumulation, mobilize Ca2+, activate phosphorylase, and inactivate glycogen synthase were all potentiated by AlCl3.	Glucagon	62-70	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
2995338-3	1985	Gs and Gi can be activated by NaF with AlCl3 as well as by agonists acting through specific receptors.	Aluminum Chloride	39-44	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
2995338-6	1985	Inhibition by NaF was enhanced synergistically by AlCl3 which alone only slightly inhibited GTPase activity.	Aluminum Chloride	50-55	C-X-C motif chemokine ligand 8	Homo sapiens	14-17
4006409-1	1985	The present work represents an attempt to develop a method for measuring relative blood flow in intestinal capillaries, by the use of sodium fluorescein (Na-F) as an indicator substance.	Fluorescein	134-152	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
2994645-2	1985	When G-protein was present NaF, at millimolar concentrations, stimulated PDE activity however, in a G-protein free extract, cGMP hydrolysis was inhibited by high fluoride concentrations.	Fluorides	162-170	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
2415257-7	1985	The binding of tritium-labeled alpha-BT and GABA to the membranes was depressed by both ouabain-containing and K-free solutions and also by compounds (theophylline and NaF) which increase the levels of intracellular ATP.	Tritium	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	168-171
2415257-7	1985	The binding of tritium-labeled alpha-BT and GABA to the membranes was depressed by both ouabain-containing and K-free solutions and also by compounds (theophylline and NaF) which increase the levels of intracellular ATP.	alpha-bt	31-39	C-X-C motif chemokine ligand 8	Homo sapiens	168-171
2415257-7	1985	The binding of tritium-labeled alpha-BT and GABA to the membranes was depressed by both ouabain-containing and K-free solutions and also by compounds (theophylline and NaF) which increase the levels of intracellular ATP.	gamma-Aminobutyric Acid	44-48	C-X-C motif chemokine ligand 8	Homo sapiens	168-171
2415257-7	1985	The binding of tritium-labeled alpha-BT and GABA to the membranes was depressed by both ouabain-containing and K-free solutions and also by compounds (theophylline and NaF) which increase the levels of intracellular ATP.	Adenosine Triphosphate	216-219	C-X-C motif chemokine ligand 8	Homo sapiens	168-171
2985653-5	1985	Gel filtration of AM culture supernatants with a G-50 Sephadex column allowed isolation of a 6,000-D neutrophil-activating factor (NAF) that was resistant to heat (56 degrees C, 30 min).	sephadex	54-62	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
4039272-2	1985	There is an increase in the number of [3H]forskolin binding sites when membranes are incubated with GppNHp or NaF in the presence of magnesium.	Magnesium	133-142	C-X-C motif chemokine ligand 8	Homo sapiens	110-113
4040041-2	1985	Ethanol up to a concentration of 5% (v/v) was without effect on basal luteal adenylyl cyclase activity, but markedly potentiated stimulation of NaF and hCG in a dose-dependent manner.	Ethanol	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	144-147
4040041-4	1985	Maximal NaF and hCG responsiveness of adenylyl cyclase activity was observed at 5% ethanol and reached values 80% and 100% higher than controls without ethanol, respectively.	Ethanol	83-90	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
4040041-4	1985	Maximal NaF and hCG responsiveness of adenylyl cyclase activity was observed at 5% ethanol and reached values 80% and 100% higher than controls without ethanol, respectively.	Ethanol	152-159	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
4040041-9	1985	These data indicate that the acute effects of ethanol inhibit forskolin-stimulated adenylyl cyclase at concentrations potentiating stimulatory effects of NaF and of hCG, and that the synergistic interaction of ethanol and gonadotropin stimulation of adenylyl cyclase is, at least in part, due to an increase in the functional coupling of the occupied hCG-receptor complex with the components of the enzyme system.	Ethanol	46-53	C-X-C motif chemokine ligand 8	Homo sapiens	154-157
4040041-9	1985	These data indicate that the acute effects of ethanol inhibit forskolin-stimulated adenylyl cyclase at concentrations potentiating stimulatory effects of NaF and of hCG, and that the synergistic interaction of ethanol and gonadotropin stimulation of adenylyl cyclase is, at least in part, due to an increase in the functional coupling of the occupied hCG-receptor complex with the components of the enzyme system.	Colforsin	62-71	C-X-C motif chemokine ligand 8	Homo sapiens	154-157
4039272-0	1985	Regulation of [3H]forskolin binding to human platelet membranes by GppNHp, NaF, and prostaglandin E1.	Tritium	15-17	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
4039272-0	1985	Regulation of [3H]forskolin binding to human platelet membranes by GppNHp, NaF, and prostaglandin E1.	Colforsin	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
4039272-2	1985	There is an increase in the number of [3H]forskolin binding sites when membranes are incubated with GppNHp or NaF in the presence of magnesium.	Tritium	39-41	C-X-C motif chemokine ligand 8	Homo sapiens	110-113
4039272-2	1985	There is an increase in the number of [3H]forskolin binding sites when membranes are incubated with GppNHp or NaF in the presence of magnesium.	Colforsin	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	110-113
2984996-2	1985	Bone resorption was increased when embryonic chick tibiae were exposed to ethanol at 0.03-0.3% (v/v), and bone formation was inhibited when tibiae were exposed to 0.2% ethanol in the presence of NaF or parathyroid hormone (P less than 0.01 for each).	Ethanol	168-175	C-X-C motif chemokine ligand 8	Homo sapiens	195-198
2984996-5	1985	Paradoxically, mitogenic doses of ethanol prevented the effects of two other mitogens, NaF and human skeletal growth factor, to increase bone cell proliferation (P less than 0.001).	Ethanol	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
2985653-8	1985	NAF was only minimally chemotactic and eluted from Sephadex G-50 with particles of a different molecular size than those of AM-derived chemotactic factors (i.e., approximately 10,000 D and less than 500 D).	sephadex	51-64	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2985653-9	1985	Preincubation of neutrophils with NAF resulted in greater release of superoxide anion upon their subsequent stimulation by either bacterial phagocytosis or by phorbol myristate acetate, as compared with control neutrophils stimulated in a like manner.	Superoxides	69-85	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
2985653-9	1985	Preincubation of neutrophils with NAF resulted in greater release of superoxide anion upon their subsequent stimulation by either bacterial phagocytosis or by phorbol myristate acetate, as compared with control neutrophils stimulated in a like manner.	Tetradecanoylphorbol Acetate	159-184	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
3977849-7	1985	Addition of La3+ directly to the adenylate cyclase assay resulted in a partial inhibition of TSH- and NaF-stimulated activity, with 50% inhibition produced by 5.1 microM and 4.0 microM-La3+ respectively.	lanthanum(3+)	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
10031523-0	1985	Observation of surface optical phonons in NaF(001) by inelastic He-atom scattering.	Helium	64-66	C-X-C motif chemokine ligand 8	Homo sapiens	42-45
2983174-6	1985	We also found that calcium reduced enzyme stimulation by forskolin and the GTP analog, guanyl 5"-yl imidodiphosphate [GMP-P(NH)P] in a dose-related manner and that activation by NaF was less sensitive to inhibition by calcium.	Calcium	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	178-181
2983174-6	1985	We also found that calcium reduced enzyme stimulation by forskolin and the GTP analog, guanyl 5"-yl imidodiphosphate [GMP-P(NH)P] in a dose-related manner and that activation by NaF was less sensitive to inhibition by calcium.	Colforsin	57-66	C-X-C motif chemokine ligand 8	Homo sapiens	178-181
2983174-6	1985	We also found that calcium reduced enzyme stimulation by forskolin and the GTP analog, guanyl 5"-yl imidodiphosphate [GMP-P(NH)P] in a dose-related manner and that activation by NaF was less sensitive to inhibition by calcium.	Guanosine Triphosphate	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	178-181
2983174-6	1985	We also found that calcium reduced enzyme stimulation by forskolin and the GTP analog, guanyl 5"-yl imidodiphosphate [GMP-P(NH)P] in a dose-related manner and that activation by NaF was less sensitive to inhibition by calcium.	guanyl 5"-yl imidodiphosphate	87-116	C-X-C motif chemokine ligand 8	Homo sapiens	178-181
2983174-6	1985	We also found that calcium reduced enzyme stimulation by forskolin and the GTP analog, guanyl 5"-yl imidodiphosphate [GMP-P(NH)P] in a dose-related manner and that activation by NaF was less sensitive to inhibition by calcium.	Guanylyl Imidodiphosphate	118-128	C-X-C motif chemokine ligand 8	Homo sapiens	178-181
2983174-6	1985	We also found that calcium reduced enzyme stimulation by forskolin and the GTP analog, guanyl 5"-yl imidodiphosphate [GMP-P(NH)P] in a dose-related manner and that activation by NaF was less sensitive to inhibition by calcium.	Calcium	218-225	C-X-C motif chemokine ligand 8	Homo sapiens	178-181
2983174-7	1985	Accordingly, at 2.5 mM CaCl2, guanyl nucleotide and forskolin stimulations were inhibited 96% and 86%, respectively, while NaF stimulation was reduced by 40%.	Calcium Chloride	23-28	C-X-C motif chemokine ligand 8	Homo sapiens	123-126
18963835-0	1985	Effect of EDTA/NaF solutions on the orion Cu(II) ion-selective electrode.	cu(ii)	42-48	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
18963835-2	1985	This effect has been found to arise from an enhanced rate of response to changes in EDTA concentration when the electrode has been exposed to an EDTA/NaF medium for prolonged periods.	Edetic Acid	84-88	C-X-C motif chemokine ligand 8	Homo sapiens	150-153
18963835-2	1985	This effect has been found to arise from an enhanced rate of response to changes in EDTA concentration when the electrode has been exposed to an EDTA/NaF medium for prolonged periods.	Edetic Acid	145-149	C-X-C motif chemokine ligand 8	Homo sapiens	150-153
3977849-7	1985	Addition of La3+ directly to the adenylate cyclase assay resulted in a partial inhibition of TSH- and NaF-stimulated activity, with 50% inhibition produced by 5.1 microM and 4.0 microM-La3+ respectively.	lanthanum(3+)	185-189	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
3977849-8	1985	Particulate preparations with La3+ showed a decrease of TSH- and NaF-stimulated adenylate cyclase activity (approx.	lanthanum(3+)	30-34	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
3855886-6	1985	The enamel biopsy data showed that the fluoride uptake resulting from 0.2% NaF alone was not statistically significant, whereas uptake produced by the DCPD-forming plus NaF rinses was significant.	Fluorides	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
2982913-8	1985	NaF (10 mM) also activated the cyclase system and produced the same magnitude of response as maximum glucagon activation.	Glucagon	101-109	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
3873544-3	1985	NaF-activated preparations were also subjected to gel filtration in the presence of CHAPS.	3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate	84-89	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
3857545-0	1985	[Effects of NaF on phenol and indole production in human saliva].	Phenol	19-25	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
2984059-2	1985	The response to Gpp(NH)p, ACTH1-24 + Gpp(NH)p and NaF was significantly lower in membranes from fetuses than from neonate lambs, whereas the response to forskolin was similar.	Phosphorus	7-8	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
3857545-0	1985	[Effects of NaF on phenol and indole production in human saliva].	indole	30-36	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
3857030-4	1985	Increasing the packing density of killed plaque residue of Streptococcus sanguis cells reduced D. Pre-incubation of plaque residue with sucrose or sucrose + NaF reduced D for lactate.	Lactic Acid	175-182	C-X-C motif chemokine ligand 8	Homo sapiens	157-160
3857987-0	1985	Fluoride uptake by dentin surfaces following topical application of TiF4, NaF and fluoride varnishes in vivo.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
6440486-4	1984	NaF-Activated preparations were also subjected to gel filtration in the presence of Chaps, in which case both the catalytic activity and G/F emerged in the activated state.	3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate	84-89	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
6440486-6	1984	NaF and guanine nucleotide sensitivity could be reconstituted in nonactivated preparations of C by G/F in the presence of NaF or guanylylimidodiphosphate.	Guanine Nucleotides	8-26	C-X-C motif chemokine ligand 8	Homo sapiens	122-125
6440486-6	1984	NaF and guanine nucleotide sensitivity could be reconstituted in nonactivated preparations of C by G/F in the presence of NaF or guanylylimidodiphosphate.	Guanylyl Imidodiphosphate	129-153	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
6397354-0	1984	[Fluoride loss from demineralized enamel after the application of different concentrations of NaF and Na-MFP solutions in an artificial mouth].	Fluorides	1-9	C-X-C motif chemokine ligand 8	Homo sapiens	94-97
6209573-3	1984	The action of beta-aminoethylisothiouronium bromide hydrobromide (AET) and sodium fluoride (NaF) on the clastogenic activity of Trenimon, cyclophosphamide, and bleomycin was tested on cultures of human peripheral lymphocytes with and without the addition of rat liver S9 mix.	Bleomycin	160-169	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
18963717-1	1984	The solubilities of LiF, NaF, KF, RbF and CsF in acetonitrile, acetone, tetrahydrofuran, dimethylformamide, benzene and cyclohexane have been determined with and without a crown ether (usually 0.1 M 18-crown-6) present.	Cyclohexane	120-131	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
3864545-0	1985	Time dependence of F uptake in demineralized enamel from 1,000-ppm fluoride NaF and Na2FPO3 solutions.	Fluorine	19-20	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
6434290-8	1984	NaF- and forskolin-stimulated enzyme activities were significantly increased by Gs in both the presence and absence of Gpp(NH)p (100 microM).	Guanylyl Imidodiphosphate	119-127	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
6373000-4	1984	Furthermore, the nonspecific esterase activity of TPA-treated cells and weak activity in 10% of untreated cells was strongly inhibited by NaF, a characteristic of monocytic series of cells.	Tetradecanoylphorbol Acetate	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	138-141
6592201-4	1984	The enamel in white spots from users of the 0.243% NaF dentifrice had a mean fluoride content higher than that from users of the 0.4% SnF2 dentifrice.	Fluorides	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
6588075-0	1984	Fluoride levels in dentin after iontophoresis of 2% NaF.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
6086524-5	1984	The neutrophil"s response to NaF was blunted by sulfinpyrazone (KI50 = 400 microM) and phenylbutazone (KI50 = 65 microM), but was unaffected by indomethacin.	Sulfinpyrazone	48-62	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
6086524-5	1984	The neutrophil"s response to NaF was blunted by sulfinpyrazone (KI50 = 400 microM) and phenylbutazone (KI50 = 65 microM), but was unaffected by indomethacin.	ki50	64-68	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
6086524-5	1984	The neutrophil"s response to NaF was blunted by sulfinpyrazone (KI50 = 400 microM) and phenylbutazone (KI50 = 65 microM), but was unaffected by indomethacin.	Phenylbutazone	87-101	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
6738571-1	1984	The effect of treatment of cultured human oral keratinocytes with sodium fluoride (NaF) has been investigated with respect to induction of unscheduled DNA synthesis (UDS).	Sodium Fluoride	66-81	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
6325278-4	1984	Within an alkali cation series (e.g. NaCH3CO2, NaF, NaCl, NaBr, NaNO3, NaI or a similar potassium series) the affinity decreased with decreasing B coefficient of viscosity.	Sodium Chloride	52-56	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
6325411-12	1984	Whereas extracts from control and butyrate-treated HeLa were equally effective in restoring NaF-stimulated activity in cyc- membranes, extracts from control HeLa were less efficient in reconstituting isoproterenol- and prostaglandin E1-stimulated activities.	Butyrates	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
6325278-4	1984	Within an alkali cation series (e.g. NaCH3CO2, NaF, NaCl, NaBr, NaNO3, NaI or a similar potassium series) the affinity decreased with decreasing B coefficient of viscosity.	Sodium Iodide	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
6325278-4	1984	Within an alkali cation series (e.g. NaCH3CO2, NaF, NaCl, NaBr, NaNO3, NaI or a similar potassium series) the affinity decreased with decreasing B coefficient of viscosity.	Potassium	88-97	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
6322840-8	1984	On photoactivation with 30 microM DAN, the NaF-stimulated adenylate cyclase was inhibited, but this effect was completely prevented by added GSH.	dan	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
6230119-4	1984	Inhibition studies of cytochemical ANAE activity with sodium fluoride (NaF) show that the presence of NaF-sensitive or NaF-resistant ANAE enzymes is often unrelated to the diagnostic category of acute leukemia.	Sodium Fluoride	54-69	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
6230119-4	1984	Inhibition studies of cytochemical ANAE activity with sodium fluoride (NaF) show that the presence of NaF-sensitive or NaF-resistant ANAE enzymes is often unrelated to the diagnostic category of acute leukemia.	Sodium Fluoride	54-69	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
6230119-4	1984	Inhibition studies of cytochemical ANAE activity with sodium fluoride (NaF) show that the presence of NaF-sensitive or NaF-resistant ANAE enzymes is often unrelated to the diagnostic category of acute leukemia.	Sodium Fluoride	54-69	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
6322840-8	1984	On photoactivation with 30 microM DAN, the NaF-stimulated adenylate cyclase was inhibited, but this effect was completely prevented by added GSH.	Glutathione	141-144	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
6418524-6	1984	Addition of 0.5 mM EGTA to the reaction mixture resulted in an approximate 30% increase in basal adenylate cyclase activity and a similar percentage increase in the activity measured in the presence of guanosine triphosphate or NaF, known activators of parathyroid adenylate cyclase.	Egtazic Acid	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	228-231
6690596-2	1984	NaF and ouabain were used to inhibit adenosine triphosphatases (ATP) and NaF and isoproterenol were used as activators of AC.	Ouabain	8-15	C-X-C motif chemokine ligand 8	Homo sapiens	73-76
6594786-11	1984	It was concluded that the posteruptively increased enamel fluorine concentration probably contributes to the caries-preventive effect of NaF tablets.	Fluorine	58-66	C-X-C motif chemokine ligand 8	Homo sapiens	137-140
6293548-1	1982	We have previously described a phosphotyrosylprotein phosphatase in membrane vesicles from human epidermoid carcinoma A431 cells which is inhibited by micromolar concentration of Zn2+ and is insensitive to ethylenediaminetetraacetic acid (EDTA) and NaF [Brautigan, D. L., Bornstein, P., & Gallis, B.	Zinc	179-183	C-X-C motif chemokine ligand 8	Homo sapiens	249-252
6315795-3	1983	Thus, upon exposure of C62B cells to catecholamine a rapid decline (t 1/2 = 6-8 min) in isoproterenol-stimulated adenylate cyclase activity occurs with minimal loss in basal or NaF-stimulated activity.	Catecholamines	37-50	C-X-C motif chemokine ligand 8	Homo sapiens	177-180
6836584-1	1983	The present study describes the effect of fluoride (10 mg NaF/kg body weight/day) on the total protein-bound sialic acid and ceruloplasmin levels in rabbit serum after receiving sodium fluoride intragastrically for 3, 5, 8 and 10 months.	Fluorides	42-50	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
6961976-4	1982	The addition of fluoride (NaF or MFP) in mouthrinses and toothpastes significantly reduced the number of new carious lesions.	Fluorides	16-24	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
6294425-5	1982	The production of cAMP following direct stimulation of adenylate cyclase by NaF was contrasted with receptor mediated activation of adenylate cyclase by prostaglandin E1 (PGE1) in disrupted platelet preparations from schizophrenics and normal controls.	Cyclic AMP	18-22	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
6294425-6	1982	cAMP formation stimulated by NaF was not different in platelets of schizophrenics as compared to controls, however, platelets of schizophrenics showed reduced response to PGE1 stimulation.	Cyclic AMP	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
6712979-5	1984	The formation of [3H]cholesteryl esters was not significantly affected by energy poisons (NaF and KCN) but was inhibited (to 50%) by chloroquine at 50 microM.	[3h]cholesteryl esters	17-39	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
6296138-5	1983	GDP also inhibited cyclase activity stimulated by NaF with UDP but did only slightly without UDP.	Guanosine Diphosphate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
6296138-5	1983	GDP also inhibited cyclase activity stimulated by NaF with UDP but did only slightly without UDP.	Uridine Diphosphate	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
6836584-1	1983	The present study describes the effect of fluoride (10 mg NaF/kg body weight/day) on the total protein-bound sialic acid and ceruloplasmin levels in rabbit serum after receiving sodium fluoride intragastrically for 3, 5, 8 and 10 months.	N-Acetylneuraminic Acid	109-120	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
6293548-1	1982	We have previously described a phosphotyrosylprotein phosphatase in membrane vesicles from human epidermoid carcinoma A431 cells which is inhibited by micromolar concentration of Zn2+ and is insensitive to ethylenediaminetetraacetic acid (EDTA) and NaF [Brautigan, D. L., Bornstein, P., & Gallis, B.	Edetic Acid	239-243	C-X-C motif chemokine ligand 8	Homo sapiens	249-252
6293548-9	1982	The phosphatase was inhibited by Zn2+ at micromolar concentrations (K0.5 with EGF receptor kinase = 5 X 10(-6) M; with CM-SC phosphorylase = 3.3 X 10(-5) M) but not by millimolar concentrations of EDTA and NaF.	Zinc	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	206-209
7115353-3	1982	In plasma membranes from control cells in the presence of heat-inactivated human erythrocyte membranes both guanosine 5"-[beta, gamma-imido]triphosphate (p[NH]ppG) plus lutropin and NaF caused a 45--50-fold increase in cyclic AMP production over 30 min compared with 12--13 fold p[NH[ppG and 2--3-fold with lutropin alone.	Cyclic AMP	219-229	C-X-C motif chemokine ligand 8	Homo sapiens	182-185
7153474-4	1982	Only the second peak reduced the NaF stimulated cAMP production.	Cyclic AMP	48-52	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
6291624-4	1982	Effects of GTP and GDP were indistinguishable in regard to their inhibitory effects on NaF-stimulated activities.	Guanosine Triphosphate	11-14	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
6291624-4	1982	Effects of GTP and GDP were indistinguishable in regard to their inhibitory effects on NaF-stimulated activities.	Guanosine Diphosphate	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
6291624-10	1982	GDP was less inhibitory than Gpp(NH)p to the NaF-stimulated adenylate cyclase activity.	Guanosine Diphosphate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
6291624-10	1982	GDP was less inhibitory than Gpp(NH)p to the NaF-stimulated adenylate cyclase activity.	Guanylyl Imidodiphosphate	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
6291624-13	1982	(3) The nucleotide regulatory site is more inhibitory to the stimulation of the enzyme by NaF when occupied by Gpp[NH]p than GDP.	Guanylyl Imidodiphosphate	111-119	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
6291624-13	1982	(3) The nucleotide regulatory site is more inhibitory to the stimulation of the enzyme by NaF when occupied by Gpp[NH]p than GDP.	Guanosine Diphosphate	125-128	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
7115353-3	1982	In plasma membranes from control cells in the presence of heat-inactivated human erythrocyte membranes both guanosine 5"-[beta, gamma-imido]triphosphate (p[NH]ppG) plus lutropin and NaF caused a 45--50-fold increase in cyclic AMP production over 30 min compared with 12--13 fold p[NH[ppG and 2--3-fold with lutropin alone.	nh[ppg	281-287	C-X-C motif chemokine ligand 8	Homo sapiens	182-185
7115353-3	1982	In plasma membranes from control cells in the presence of heat-inactivated human erythrocyte membranes both guanosine 5"-[beta, gamma-imido]triphosphate (p[NH]ppG) plus lutropin and NaF caused a 45--50-fold increase in cyclic AMP production over 30 min compared with 12--13 fold p[NH[ppG and 2--3-fold with lutropin alone.	Luteinizing Hormone	307-315	C-X-C motif chemokine ligand 8	Homo sapiens	182-185
6177249-7	1982	In fact, the role of NaF therapy could already be taken over by diphosphonates currently under study.	Diphosphonates	64-78	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
6951705-0	1982	[Fluoride uptake and retention in the dental enamel of adults after the application of NaF tablets and NaF gel in vivo].	Fluorides	1-9	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
6951705-0	1982	[Fluoride uptake and retention in the dental enamel of adults after the application of NaF tablets and NaF gel in vivo].	Fluorides	1-9	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
6961914-0	1982	Effect of extracellular polysaccharides on diffusion of NaF and [14C]-sucrose in human dental plaque and in sediments of the bacterium Streptococcus sanguis 804 (NCTC 10904).	Polysaccharides	24-39	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
6961914-3	1982	sanguis 804 at 37 degrees C. There was a tendency for NaF and [14C]-sucrose to diffuse faster as the carbohydrate concentration in the sediments increased.	Carbohydrates	101-113	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
6961914-4	1982	NaF diffused only 38 per cent more slowly in cell-free glucan sediment than in water, suggesting that glucan per se does not form a barrier to diffusion.	Glucans	55-61	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
6961914-5	1982	The diffusion coefficient for NaF was positively correlated with carbohydrate concentration in individual plaque samples from 15 subjects and incubation of 3 plaque samples with sucrose resulted in both an increase in carbohydrate concentration in the plaque and an increase in D for NaF.	Carbohydrates	65-77	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
6961914-5	1982	The diffusion coefficient for NaF was positively correlated with carbohydrate concentration in individual plaque samples from 15 subjects and incubation of 3 plaque samples with sucrose resulted in both an increase in carbohydrate concentration in the plaque and an increase in D for NaF.	Sucrose	178-185	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
6961914-5	1982	The diffusion coefficient for NaF was positively correlated with carbohydrate concentration in individual plaque samples from 15 subjects and incubation of 3 plaque samples with sucrose resulted in both an increase in carbohydrate concentration in the plaque and an increase in D for NaF.	Sucrose	178-185	C-X-C motif chemokine ligand 8	Homo sapiens	284-287
6961914-5	1982	The diffusion coefficient for NaF was positively correlated with carbohydrate concentration in individual plaque samples from 15 subjects and incubation of 3 plaque samples with sucrose resulted in both an increase in carbohydrate concentration in the plaque and an increase in D for NaF.	Carbohydrates	218-230	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
7121252-2	1982	The dose of NaF was modified according to the serum fluoride concentration, which was kept as constant as possible between 0.20 and 0.25 microgram/ml.	Fluorides	52-60	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
6263877-3	1981	The reconstitution process in the presence of guanyl-5"-yl imidodiphosphate or NaF is time-dependent, directly proportional to the quantity of erythrocyte protein added to the reconstitution system, and is only observed when Mg-ATP is used as substrate.	Adenosine Triphosphate	225-231	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
7287864-3	1981	The activity of the enzyme was inhibited by preincubation of microsomes with ATP (4 mM) and was greatly reduced when microsomes were prepared from tissue homogenized in the presence of NaF (50 mM).	Adenosine Triphosphate	77-80	C-X-C motif chemokine ligand 8	Homo sapiens	185-188
19701426-0	1981	Laser-active, defect-stabilized F2+ center in NAF:OH- and dynamics of defect-stabilized center formation.	f2+	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
6946109-0	1981	Fluoride uptake from in situ brushing with a SnF2 and a NaF dentifrice.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
6946109-1	1981	Fluoride uptake into decalcified human enamel was determined from in situ brushing with a 0.40% SnF2-calcium pyrophosphate abrasive dentifrice, a 0.243% NaF-silica abrasive dentifrice, and a non-fluoride-silica abrasive placebo dentifrice.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	153-156
6946109-1	1981	Fluoride uptake into decalcified human enamel was determined from in situ brushing with a 0.40% SnF2-calcium pyrophosphate abrasive dentifrice, a 0.243% NaF-silica abrasive dentifrice, and a non-fluoride-silica abrasive placebo dentifrice.	Silicon Dioxide	157-163	C-X-C motif chemokine ligand 8	Homo sapiens	153-156
6946109-4	1981	The mean fluoride contents after use of the test dentifrices were 16.0, 8.4, and 4.6 micro/cm2 for the 0.243% NaF, the 0.40% SnF2, and the placebo dentifrice, respectively.	Fluorides	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	110-113
7317821-5	1981	Activation of the heart and skeletal muscle enzyme by NaF and GPP(NH)P greatly reduced the Mg2+ requirement; this was seen with both particulate and solubilized preparations.	magnesium ion	91-95	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
7315114-8	1981	Prior to incubation the erythrocytes were stored with NaF in order to reduce the total adenylate concentration.	Adenosine Monophosphate	87-96	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
7207691-0	1981	A subacute fluoride intoxication during treatment of osteoporosis with sodium fluoride (NaF): case report.	Fluorides	11-19	C-X-C motif chemokine ligand 8	Homo sapiens	88-91
6935392-3	1981	The most elevated release of fluoride from the NaF containing--and the most protracted from the CaF2 containing--plates may be related to the solubilities of the compounds.	Fluorides	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
7207691-0	1981	A subacute fluoride intoxication during treatment of osteoporosis with sodium fluoride (NaF): case report.	Sodium Fluoride	71-86	C-X-C motif chemokine ligand 8	Homo sapiens	88-91
7417708-3	1980	This drug-induced movement of 45Ca to membrane sites was blocked by depleting erythrocytes of adenosine triphosphate (ATP) or by incubating them with known inhibitors of endocytosis, NaF of N-ethylmaleimide (NEM).	Ethylmaleimide	190-206	C-X-C motif chemokine ligand 8	Homo sapiens	183-186
7291201-6	1981	Prior to incubation the erythrocytes were stored with NaF in order to reduce the total adenylate concentration.	Adenosine Monophosphate	87-96	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
7204643-2	1980	To test for the possible origin of these labeled cells from monocytes, we examined them for the presence of sodium fluoride- (NaF) sensitive non-specific esterase (NSE), an enzyme characteristic of monocytes.	Sodium Fluoride	108-123	C-X-C motif chemokine ligand 8	Homo sapiens	126-129
6258579-11	1980	Half-maximum inhibition of the phosphatase by 5,5"-dithiobis-(2-nitrobenzoate), EDTA and NaF is obtained at 0.5 microM, 1 mM and 4 mM respectively.	5,5"-dithiobis-(2-nitrobenzoate)	46-78	C-X-C motif chemokine ligand 8	Homo sapiens	89-92
6935963-1	1980	A laboratory study was carried out to evaluate the effectiveness of NaF and SnF2, when incorporated into zinc oxyphosphate cement, in reducing the solubility and increasing the microhardness of human enamel.	zinc oxyphosphate	105-122	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
7417708-3	1980	This drug-induced movement of 45Ca to membrane sites was blocked by depleting erythrocytes of adenosine triphosphate (ATP) or by incubating them with known inhibitors of endocytosis, NaF of N-ethylmaleimide (NEM).	Ethylmaleimide	208-211	C-X-C motif chemokine ligand 8	Homo sapiens	183-186
6932085-0	1980	Effect of mouthrinses with SnF2, LaCl3, NaF and chlorhexidine on the amount of lipoteichoic acid formed in plaque.	lipoteichoic acid	79-96	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
6931113-2	1980	The sustained F-release was achieved by embedding NaF in ethyl cellulose and silicone polymer, both known to be nontoxic and insoluble in saliva.	ethyl cellulose	57-72	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
7419155-1	1980	The plasma fluoride concentration after oral administration of 40 mg of NaF in delayed and nondelayed form depending on the thyroid function].	Fluorides	11-19	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
6251111-4	1980	Glutamic acid and aspartic acid together accounted for a total of 18 and 19% of the amino acids in purified preparations of NAF I and NAF II, respectively, whereas the basic amino acids lysine, arginine, and histidine represented <2 and 3% of the total residues.	Glutamic Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	124-127
6251111-4	1980	Glutamic acid and aspartic acid together accounted for a total of 18 and 19% of the amino acids in purified preparations of NAF I and NAF II, respectively, whereas the basic amino acids lysine, arginine, and histidine represented <2 and 3% of the total residues.	Glutamic Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	134-137
6251111-4	1980	Glutamic acid and aspartic acid together accounted for a total of 18 and 19% of the amino acids in purified preparations of NAF I and NAF II, respectively, whereas the basic amino acids lysine, arginine, and histidine represented <2 and 3% of the total residues.	Aspartic Acid	18-31	C-X-C motif chemokine ligand 8	Homo sapiens	124-127
6251111-4	1980	Glutamic acid and aspartic acid together accounted for a total of 18 and 19% of the amino acids in purified preparations of NAF I and NAF II, respectively, whereas the basic amino acids lysine, arginine, and histidine represented <2 and 3% of the total residues.	Aspartic Acid	18-31	C-X-C motif chemokine ligand 8	Homo sapiens	134-137
6768782-2	1980	Surfaces remineralized 25 hours in 0.4 mM NaF (8 ppm F-) dissolved slower in acid or in EDTA than those remineralized in the absence of F-.	Edetic Acid	88-92	C-X-C motif chemokine ligand 8	Homo sapiens	42-45
6108993-12	1980	The ATP hydrolysis activity was inhibited by NaF but unaffected by ouabain, vanadate, cytochalasin B, and various drugs known to influence ATPase activity of mitochondria.	Adenosine Triphosphate	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
6934618-4	1980	Sucking NaF tablets caused a fall in initial pH and an increase in total calcium, while the amount of ionized calcium remained unchanged.	Calcium	73-80	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
6934618-5	1980	The content of fluoride was high in saliva during sucking of NaF tablets.	Fluorides	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	61-64
6929286-0	1980	Fluroide concentration in enamel treated with 50% phosphoric acid and NaF with subsequent decalcification in "acid-gel".	fluroide	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	70-73
6246514-11	1980	Time course studies utilizing pyrophosphate as the phosphate source showed only one phase of phosphorylation that was strongly inhibited by micromolar levels of ATP as well as by NaF (5 mM).	diphosphoric acid	30-43	C-X-C motif chemokine ligand 8	Homo sapiens	179-182
7396871-9	1980	At high concentrations (greater than 3 mM) N alpha-tosylarginine methyl ester also inhibited NaF- and guanosine 5"-[beta gamma-imidol]-triphosphate-stimulated cyclase but in a reversible manner.	n alpha-tosylarginine methyl ester	43-77	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
7396871-10	1980	7-Amino-1-chloro-3-L-tosylamidoheptan-2-one inhibited NaF-stimulated adenylate cyclase in two ways, as for human-choriogonadotropin-stimulated adenylate cyclase, but required 10--20-fold higher concentrations.	7-amino-1-chloro-3-l-tosylamidoheptan-2-one	0-43	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
6935030-0	1980	[Fluoride uptake and retention in the dental enamel after the application of NaF tablets in schoolchildren].	Fluorides	1-9	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
6246514-11	1980	Time course studies utilizing pyrophosphate as the phosphate source showed only one phase of phosphorylation that was strongly inhibited by micromolar levels of ATP as well as by NaF (5 mM).	Phosphates	34-43	C-X-C motif chemokine ligand 8	Homo sapiens	179-182
7009669-2	1980	Results indicated that 2.5% NaF in the etchant prevent the sealant bond, but addition of 0.02% NaF resulted in an increase in fluoride content of the enamel surface without a decrease in bond strength.	Fluorides	126-134	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
6103847-3	1980	The present study analyzes the effects of heparin and sodium fluoride (NaF) on these changes.	Sodium Fluoride	54-69	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
40394-5	1979	Incorporation of leucine was then stimulated by low fluoride concentrations (0.5 and 0.9 mM), and the effect on thymidine incorporation was eradicated up to 1.3 mM-NaF.	Leucine	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	164-167
6928001-4	1980	Smooth surface adherence by both fluoride-sensitive and -resistant strains of S. mutans 6715 in a tooth model system was slightly diminished by 1% NaF gel.	Fluorides	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	147-150
6938993-1	1980	Three types of sustained and controlled release dosage forms of sodium fluoride (NaF) for the prevention of dental caries are reviewed.	Sodium Fluoride	64-79	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
6938993-2	1980	Sustained release NaF tablets or capsules have prolonged the elevation of saliva and plasma fluoride levels in both animal and human studies when compared to conventional NaF tablets.	Fluorides	92-100	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
6938993-3	1980	In vitro studies have shown that aerosol application of NaF-containing microcapsules to the tooth surface may prolong the retention of a given dose of fluoride in the mouth and also increase enamel uptake of fluoride.	Fluorides	151-159	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
6938993-3	1980	In vitro studies have shown that aerosol application of NaF-containing microcapsules to the tooth surface may prolong the retention of a given dose of fluoride in the mouth and also increase enamel uptake of fluoride.	Fluorides	208-216	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
41586-5	1979	The solubilized monoacylglycerol hydrolase from platelets was optimally active at pH between 7 and 8 and at ionic strength corresponding to [NaCl] between 0.1 and 0.3 M. The optimal assay temperature was 37 degrees C. The enzyme activity was sensitive to HgCl2 but not to NaF.	Sodium Chloride	141-145	C-X-C motif chemokine ligand 8	Homo sapiens	272-275
28310569-0	1980	The simultaneous effect of soil-borne NaF and air pollutant SO2 on CO2-uptake and pollutant accumulation.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
263633-1	1979	The complete neglect of differential overlap method is used to investigate the binding of LiF, LiCl, NaF, and NaCl to N-methyl acetamide (NMA) as a model for these ions binding to a peptide moiety.	N-methylacetamide	118-136	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
263633-1	1979	The complete neglect of differential overlap method is used to investigate the binding of LiF, LiCl, NaF, and NaCl to N-methyl acetamide (NMA) as a model for these ions binding to a peptide moiety.	N-methylacetamide	138-141	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
40394-5	1979	Incorporation of leucine was then stimulated by low fluoride concentrations (0.5 and 0.9 mM), and the effect on thymidine incorporation was eradicated up to 1.3 mM-NaF.	Thymidine	112-121	C-X-C motif chemokine ligand 8	Homo sapiens	164-167
427219-6	1979	Stimulation by adenosine was additive with the effects of GMP-P(NH)P, and alpha- or beta-adrenergic stimulation, but was abolished by prostaglandin E1 or by NaF.	Adenosine	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	157-160
379285-1	1979	The tensile bond strength of Epoxylite 9075 and Enamelite to enamel treated with NaF and SnF2, at two concentrations, in the etching acid (H3PO4) was determined.	epoxylite	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
379285-1	1979	The tensile bond strength of Epoxylite 9075 and Enamelite to enamel treated with NaF and SnF2, at two concentrations, in the etching acid (H3PO4) was determined.	etching acid	125-137	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
379285-4	1979	Incorporation of NaF or SnF2 in the etching solutions highly increased the fluoride concentration of enamel.	Fluorides	75-83	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
379285-5	1979	The fluoride increase dependend on the fluoride concentration of the etching solution and was greater for NaF than SnF2.	Fluorides	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	106-109
379285-5	1979	The fluoride increase dependend on the fluoride concentration of the etching solution and was greater for NaF than SnF2.	Fluorides	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	106-109
293239-2	1979	The combined effect of fissure sealing and topical fluoride therapy with 2% NaF gel resulted over the 2 years in an increase in the proportion of caries-free permanent first molars from 50% to 81% in the 1st grade.	Fluorides	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
427219-7	1979	Prostaglandin E1 and NaF increased the sensitivity of adenylate cyclase to inhibition by adenosine.	Adenosine	89-98	C-X-C motif chemokine ligand 8	Homo sapiens	0-24
368092-0	1979	Treatment of enamel with 50% phosphoric acid containing 0.5% and 2% NaF.	phosphoric acid	29-44	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
292158-2	1979	The amount of fluoride extractable from dentrifrices containing 0.1% NaF and the fluoride ion activity were not reduced by the addition of 2% chlorhexidine digluconate.	Fluorides	14-22	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
25551-3	1978	NaF, at 1 and 5 mM, progressively increased this parameter while norepinephrine caused a similar effect at 10(-3) but not at 10(-6) M. Phentolamine (1 mM) blocked the stimulatory action of TSH; propranolol and atropine did not.	Phentolamine	135-147	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
759278-1	1979	The bioavailability of Ossin, a drug for the treatment of osteoporosis, containing 40 mg of NaF, was investigated.	Sodium Fluoride	23-28	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
580872-1	1978	Thyrotropin (TSH)- and sodium fluoride (NaF)-sensitive adenylate cyclase (AC) activity was measured in ten cases of "cold" thyroid nodules and compared with perinodular tissue.	Sodium Fluoride	23-38	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
207727-2	1978	The present study examined PMN CL in the absence of phagocytosis using sodium fluoride (NaF), a nonparticulate agent and known stimulator of cellular oxidative metabolism.	Sodium Fluoride	71-86	C-X-C motif chemokine ligand 8	Homo sapiens	88-91
207727-5	1978	Superoxide anion production correlated closely with CL responses in NaF-treated human PMNs.	Superoxides	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
207727-6	1978	CL responses were completely suppressed in the presence of the oxidative metabolic inhibitors, iodoacetamide, and N-ethylmalemide; and were partially suppressed in the presence of either superoxide dismutase or sodium azide.CL responses of NaF-treated PMNs were significantly lower than responses generated by PMNs phagocytizing opsonized yeast.	Iodoacetamide	95-108	C-X-C motif chemokine ligand 8	Homo sapiens	240-243
207727-6	1978	CL responses were completely suppressed in the presence of the oxidative metabolic inhibitors, iodoacetamide, and N-ethylmalemide; and were partially suppressed in the presence of either superoxide dismutase or sodium azide.CL responses of NaF-treated PMNs were significantly lower than responses generated by PMNs phagocytizing opsonized yeast.	n-ethylmalemide	114-129	C-X-C motif chemokine ligand 8	Homo sapiens	240-243
207727-6	1978	CL responses were completely suppressed in the presence of the oxidative metabolic inhibitors, iodoacetamide, and N-ethylmalemide; and were partially suppressed in the presence of either superoxide dismutase or sodium azide.CL responses of NaF-treated PMNs were significantly lower than responses generated by PMNs phagocytizing opsonized yeast.	Sodium Azide	211-223	C-X-C motif chemokine ligand 8	Homo sapiens	240-243
212438-5	1978	It is reported herein that the degradation of receptor-bound human choriogonadotropin is an energy-dependent process, which can be inhibited by compounds that interfere with glycolysis or oxidative phosphorylation (e.g. NaF, NaN3, NaCN, and 2-deoxyglucose).	Sodium Azide	225-229	C-X-C motif chemokine ligand 8	Homo sapiens	220-223
212438-5	1978	It is reported herein that the degradation of receptor-bound human choriogonadotropin is an energy-dependent process, which can be inhibited by compounds that interfere with glycolysis or oxidative phosphorylation (e.g. NaF, NaN3, NaCN, and 2-deoxyglucose).	Sodium Cyanide	231-235	C-X-C motif chemokine ligand 8	Homo sapiens	220-223
212438-5	1978	It is reported herein that the degradation of receptor-bound human choriogonadotropin is an energy-dependent process, which can be inhibited by compounds that interfere with glycolysis or oxidative phosphorylation (e.g. NaF, NaN3, NaCN, and 2-deoxyglucose).	Deoxyglucose	241-255	C-X-C motif chemokine ligand 8	Homo sapiens	220-223
707137-2	1978	In intact, sensitive cells, 6 mM NaF had no effect on glycolysis, whereas in homogenates, from both resistant and sensitive cells, lactate production was blocked by 6 mM NaF, indicating the cell membrane to be a barrier to fluoride.	Lactic Acid	131-138	C-X-C motif chemokine ligand 8	Homo sapiens	170-173
707137-2	1978	In intact, sensitive cells, 6 mM NaF had no effect on glycolysis, whereas in homogenates, from both resistant and sensitive cells, lactate production was blocked by 6 mM NaF, indicating the cell membrane to be a barrier to fluoride.	Fluorides	223-231	C-X-C motif chemokine ligand 8	Homo sapiens	170-173
684703-0	1978	[Discontinuing NAF-drugs oral morphine and peteridine/preparations--tablets from digitalis leaves].	Morphine	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
278984-1	1978	The mechanism of activation of adenylate cyclase by guanylyl-5"-imidodiphosphate [Gpp(NH)p] and NaF has been investigated by studying the reconstitution of Gpp(NH)p and NaF sensitivity of an enzyme rendered insensitive to these agents by differential detergent extraction of a particulate brain enzyme.	guanylyl-5"-imidodiphosphate	52-80	C-X-C motif chemokine ligand 8	Homo sapiens	169-172
278984-1	1978	The mechanism of activation of adenylate cyclase by guanylyl-5"-imidodiphosphate [Gpp(NH)p] and NaF has been investigated by studying the reconstitution of Gpp(NH)p and NaF sensitivity of an enzyme rendered insensitive to these agents by differential detergent extraction of a particulate brain enzyme.	Guanylyl Imidodiphosphate	82-90	C-X-C motif chemokine ligand 8	Homo sapiens	169-172
25551-3	1978	NaF, at 1 and 5 mM, progressively increased this parameter while norepinephrine caused a similar effect at 10(-3) but not at 10(-6) M. Phentolamine (1 mM) blocked the stimulatory action of TSH; propranolol and atropine did not.	Thyrotropin	189-192	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
25551-3	1978	NaF, at 1 and 5 mM, progressively increased this parameter while norepinephrine caused a similar effect at 10(-3) but not at 10(-6) M. Phentolamine (1 mM) blocked the stimulatory action of TSH; propranolol and atropine did not.	Propranolol	194-205	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
25551-3	1978	NaF, at 1 and 5 mM, progressively increased this parameter while norepinephrine caused a similar effect at 10(-3) but not at 10(-6) M. Phentolamine (1 mM) blocked the stimulatory action of TSH; propranolol and atropine did not.	Atropine	210-218	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
208916-0	1978	The relationship between contractile tension and intracellular cyclic AMP level in frog atrium: an analysis by using NaF, verapamil and ouabain.	Cyclic AMP	63-73	C-X-C motif chemokine ligand 8	Homo sapiens	117-120
274261-4	1978	The highest initial fluoride concentration was achieved with NaF (pH 4.0) and Na3FeF6 in combination with NaF, CaF2 and MgF2 (pH 4.0) whereas the greatest stability was reached with NaF.	Fluorides	20-28	C-X-C motif chemokine ligand 8	Homo sapiens	61-64
274261-4	1978	The highest initial fluoride concentration was achieved with NaF (pH 4.0) and Na3FeF6 in combination with NaF, CaF2 and MgF2 (pH 4.0) whereas the greatest stability was reached with NaF.	Fluorides	20-28	C-X-C motif chemokine ligand 8	Homo sapiens	106-109
274261-4	1978	The highest initial fluoride concentration was achieved with NaF (pH 4.0) and Na3FeF6 in combination with NaF, CaF2 and MgF2 (pH 4.0) whereas the greatest stability was reached with NaF.	Fluorides	20-28	C-X-C motif chemokine ligand 8	Homo sapiens	106-109
623787-1	1978	At a temperature just above the collagen denaturation point the aluminium walls of the pans used in microcalorimetric measurements react exothermically with NaF in test solutions.	Aluminum	64-73	C-X-C motif chemokine ligand 8	Homo sapiens	157-160
624406-0	1978	The monovalent anions chloride and azide as potent activators of NaF- and p(NH)ppG-stimulation of pancreatic adenylate cyclase.	Chlorides	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
624406-0	1978	The monovalent anions chloride and azide as potent activators of NaF- and p(NH)ppG-stimulation of pancreatic adenylate cyclase.	Azides	35-40	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
738539-6	1978	Since basal, NaF- and guanylyl-imidodiphosphate-stimulated enzyme activities were also affected by this compound, we may conclude that RMI 12330 A is a non-specific inhibitor of the human colonic adenylate cyclase system.	RMI 12330A	135-146	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
269079-2	1977	It was shown that the fluoride concentration was highest when NaF was administered.	Fluorides	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	62-65
412926-2	1977	NaF in CO2-free solutions increased the rates of calcium and phosphate uptake during remineralization.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	7-10	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
412926-2	1977	NaF in CO2-free solutions increased the rates of calcium and phosphate uptake during remineralization.	Calcium	49-56	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
412926-2	1977	NaF in CO2-free solutions increased the rates of calcium and phosphate uptake during remineralization.	Phosphates	61-70	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
412926-3	1977	Bicarbonate in NaF-free solutions caused small increases of calcium and phosphate uptake.	Bicarbonates	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
412926-3	1977	Bicarbonate in NaF-free solutions caused small increases of calcium and phosphate uptake.	Calcium	60-67	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
412926-3	1977	Bicarbonate in NaF-free solutions caused small increases of calcium and phosphate uptake.	Phosphates	72-81	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
412926-4	1977	Bicarbonate with NaF in solutions synergistically increased calcium uptake, but did not affect phosphate uptake.	Bicarbonates	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
412926-4	1977	Bicarbonate with NaF in solutions synergistically increased calcium uptake, but did not affect phosphate uptake.	Calcium	60-67	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
199608-2	1977	Two relatively specific inhibitors of glycolysis (iodoacetate [IA], and sodium fluoride [NaF]) and a sulfhydryl-binding agent (N-ethylmaleimide [NEM] markedly inhibited phagocytosis and reduced cell deformability.	Sodium Fluoride	72-87	C-X-C motif chemokine ligand 8	Homo sapiens	89-92
272381-1	1977	Upon exposure to laser radiation, enamel powder mixed with NaF underwent an increase in crystallite size and/or perfection with a significant uptake of fluoride.	Fluorides	152-160	C-X-C motif chemokine ligand 8	Homo sapiens	59-62
272381-2	1977	Incisor teeth lased in the presence of NaF released significantly less calcium and phosphorus into sodium acetate (pH 4.0) compared with unlased controls, suggesting a possible role for the laser in caries prevention.	Calcium	71-78	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
272381-2	1977	Incisor teeth lased in the presence of NaF released significantly less calcium and phosphorus into sodium acetate (pH 4.0) compared with unlased controls, suggesting a possible role for the laser in caries prevention.	Phosphorus	83-93	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
272381-2	1977	Incisor teeth lased in the presence of NaF released significantly less calcium and phosphorus into sodium acetate (pH 4.0) compared with unlased controls, suggesting a possible role for the laser in caries prevention.	Sodium Acetate	99-113	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
910903-5	1977	The intake of about 10 mg fluoride per day, given as NaF, resulted in a two- to threefold increase of the urinary and fecal fluoride excretion.	Fluorides	26-34	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
910903-5	1977	The intake of about 10 mg fluoride per day, given as NaF, resulted in a two- to threefold increase of the urinary and fecal fluoride excretion.	Fluorides	124-132	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
603776-5	1977	A histiocytic lymphoma cell line was strongly esterase positive with naphtol AS-D acetate esterase inhibited by NaF.	naphtol	69-76	C-X-C motif chemokine ligand 8	Homo sapiens	112-115
890460-5	1977	After restoration of uptake with SMP the amino acid uptake was resistant to NaF, but was markedly more sensitive to arsenite and oligomycin.	smp	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
303821-4	1977	A 15 minutes incubation produced a similar effect as that observed in winter (32.8% P less than 0.05) A 15 minutes maintenance of muscles in a weak solution of NaF while increasing their resistance to the inhibitor was found to decrease their resistance to an injurious ethanol solution (3.48 M), and to 36 degrees, by 58 and 53%, respectively.	Ethanol	270-277	C-X-C motif chemokine ligand 8	Homo sapiens	160-163
196990-2	1977	Clofibrate reduced basal as well as hormone-NaF)stimulated adenylate cyclase activities to about the same extent (45% inhibition at 1 mg/ml clofibrate).	Clofibrate	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	44-47
873155-1	1977	The adenylate cyclase system of human fundic gastric mucosa was found to respond to histamine, prostaglandin E 2 and the non-hormonal activators NaF and 5"-guanylyl-imidodiphosphate (GMP(PNP)).	4-nitrophenol	187-190	C-X-C motif chemokine ligand 8	Homo sapiens	145-148
873155-6	1977	NaF and GMP(PNP) by inducing an about 3.5-fold increase of enzyme activity were more potent in stimulating the human enzyme system than histamine and prostaglandin E 2.	4-nitrophenol	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
873155-6	1977	NaF and GMP(PNP) by inducing an about 3.5-fold increase of enzyme activity were more potent in stimulating the human enzyme system than histamine and prostaglandin E 2.	Histamine	136-145	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
873155-6	1977	NaF and GMP(PNP) by inducing an about 3.5-fold increase of enzyme activity were more potent in stimulating the human enzyme system than histamine and prostaglandin E 2.	Dinoprostone	150-167	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
18332-3	1977	To demonstrate fluorine availability at the enamel surface daily profiles of fluorine concentration in the saliva of seven subjects after a single administration of a NaF and Na3FeF6 tablet are presented and their effect on the remineralization of the dental enamel described.	Fluorine	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	167-170
186585-8	1976	Dithiobisnitrobenzoic acid and alloxan, inhibitors of adenylate cyclase, impaired neuromuscular transmission and prevented the effects of NaF, but they did not change the responses to dibutyryl cAMP.	Dithionitrobenzoic Acid	0-26	C-X-C motif chemokine ligand 8	Homo sapiens	138-141
836841-4	1977	Carnitine uptake is suppressed 90% by NaF (24MM).	Carnitine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
189821-2	1977	The glycolysis inhibitors, NaF and monoiodoacetate, inhibited epinephrine or theophylline-stimulated lipolysis and parallely reduced the intracellular cyclic AMP and ATP levels; however, neither NaF nor monoidoacetate significantly affected dibutyryl cyclic AMP-induced lipolysis.	Epinephrine	62-73	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
189821-2	1977	The glycolysis inhibitors, NaF and monoiodoacetate, inhibited epinephrine or theophylline-stimulated lipolysis and parallely reduced the intracellular cyclic AMP and ATP levels; however, neither NaF nor monoidoacetate significantly affected dibutyryl cyclic AMP-induced lipolysis.	Theophylline	77-89	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
189821-2	1977	The glycolysis inhibitors, NaF and monoiodoacetate, inhibited epinephrine or theophylline-stimulated lipolysis and parallely reduced the intracellular cyclic AMP and ATP levels; however, neither NaF nor monoidoacetate significantly affected dibutyryl cyclic AMP-induced lipolysis.	Cyclic AMP	151-161	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
189821-2	1977	The glycolysis inhibitors, NaF and monoiodoacetate, inhibited epinephrine or theophylline-stimulated lipolysis and parallely reduced the intracellular cyclic AMP and ATP levels; however, neither NaF nor monoidoacetate significantly affected dibutyryl cyclic AMP-induced lipolysis.	Adenosine Triphosphate	166-169	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
189821-2	1977	The glycolysis inhibitors, NaF and monoiodoacetate, inhibited epinephrine or theophylline-stimulated lipolysis and parallely reduced the intracellular cyclic AMP and ATP levels; however, neither NaF nor monoidoacetate significantly affected dibutyryl cyclic AMP-induced lipolysis.	monoidoacetate	203-217	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
189821-2	1977	The glycolysis inhibitors, NaF and monoiodoacetate, inhibited epinephrine or theophylline-stimulated lipolysis and parallely reduced the intracellular cyclic AMP and ATP levels; however, neither NaF nor monoidoacetate significantly affected dibutyryl cyclic AMP-induced lipolysis.	dibutyryl	241-250	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
189821-2	1977	The glycolysis inhibitors, NaF and monoiodoacetate, inhibited epinephrine or theophylline-stimulated lipolysis and parallely reduced the intracellular cyclic AMP and ATP levels; however, neither NaF nor monoidoacetate significantly affected dibutyryl cyclic AMP-induced lipolysis.	Cyclic AMP	251-261	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
1000801-2	1976	The most commonly used preservative, NaF, makes analysis of other serum constituents such as sodium and calcium and urea difficult or impossible, an especially serious limitation when sample size must be restricted.	Sodium	93-99	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
1000801-2	1976	The most commonly used preservative, NaF, makes analysis of other serum constituents such as sodium and calcium and urea difficult or impossible, an especially serious limitation when sample size must be restricted.	Calcium	104-111	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
1000801-2	1976	The most commonly used preservative, NaF, makes analysis of other serum constituents such as sodium and calcium and urea difficult or impossible, an especially serious limitation when sample size must be restricted.	Urea	116-120	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
186585-8	1976	Dithiobisnitrobenzoic acid and alloxan, inhibitors of adenylate cyclase, impaired neuromuscular transmission and prevented the effects of NaF, but they did not change the responses to dibutyryl cAMP.	Alloxan	31-38	C-X-C motif chemokine ligand 8	Homo sapiens	138-141
1024309-5	1976	A study of non-specificity of the adaptive effect of low alcohol decreased their resistance to 0.12 M NaF by 33.3% (P less than 0.05) The same concentration of ethyl alcohol applied for periods from 15 mintes to 2 hours either caused no change or decreased significantly the resistance of muscle tissue to the temperature 36 degrees C. This effect of decrease in resistance was even more significant when the resistance to 38 degrees C was challenged.	Alcohols	57-64	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
1004515-6	1976	Continuous treatment of the cells with 10(-3) M NaF had no effect on [3H]TdR labelling or mitotic indices in otherwise untreated cultures, but led to an impressive effect on DNA synthesis in Trenimon-treated cultures, without a considerable effect on the mitotic indices.	Triaziquone	191-199	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
1067316-1	1976	The acid resistance of powdered human dentin increased linearly after pretreatments in 2.5, 25, 250, and 1,000 mM NaF in water.	Water	121-126	C-X-C motif chemokine ligand 8	Homo sapiens	114-117
1068502-4	1976	The F uptake by enamel surfaces from 0.25 mM NaF in 175 mM NaCl, corresponding to a dish prepared with salt containing 500 parts/106 F, was about 80% greater than from the same NaF concentration in water.	Sodium Chloride	59-63	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
10891-13	1976	Inorganic salts (e.g. NaCl, KCl, LiBr, NaF) produced inhibition of particulate enzyme; the degree of inhibition of Triton X-100-stimulated activity was less than that of unstimulated activity.	inorganic salts	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
10891-13	1976	Inorganic salts (e.g. NaCl, KCl, LiBr, NaF) produced inhibition of particulate enzyme; the degree of inhibition of Triton X-100-stimulated activity was less than that of unstimulated activity.	Octoxynol	115-127	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
184132-1	1976	The data obtained in this in vitro study indicate that contact with pit and fissure sealants to which NaF has been added in amounts ranging from 2 to 5% substantially increases the fluoride content of the enamel and reduces its solubility in acid.	Fluorides	181-189	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
822869-6	1976	Inhibition of reinitiation with NaF or poly (AUG) reduced the rate of amino acid polymerization by 45% but the aldosterone to control ratio remained significantly high.	Aldosterone	111-122	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
1068502-4	1976	The F uptake by enamel surfaces from 0.25 mM NaF in 175 mM NaCl, corresponding to a dish prepared with salt containing 500 parts/106 F, was about 80% greater than from the same NaF concentration in water.	Salts	103-107	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
179579-2	1976	This enzymatic activity is strongly stimulated by NaF and 5"-guanylimidodiphosphate, is slightly stimulated by epinephrine, norepinephrine, isoproterenol, and prostaglandin E1 and is inhibited by calcium.	Calcium	196-203	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
179579-2	1976	This enzymatic activity is strongly stimulated by NaF and 5"-guanylimidodiphosphate, is slightly stimulated by epinephrine, norepinephrine, isoproterenol, and prostaglandin E1 and is inhibited by calcium.	Epinephrine	111-122	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
179579-2	1976	This enzymatic activity is strongly stimulated by NaF and 5"-guanylimidodiphosphate, is slightly stimulated by epinephrine, norepinephrine, isoproterenol, and prostaglandin E1 and is inhibited by calcium.	Norepinephrine	124-138	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
1225875-5	1975	Prerinsing with sodium lauryl sulfate or cetylaminechloride annihilated the F clearance superiority of cetylaminefluoride over NaF.	cetylaminechloride	41-59	C-X-C motif chemokine ligand 8	Homo sapiens	127-130
179579-2	1976	This enzymatic activity is strongly stimulated by NaF and 5"-guanylimidodiphosphate, is slightly stimulated by epinephrine, norepinephrine, isoproterenol, and prostaglandin E1 and is inhibited by calcium.	Isoproterenol	140-153	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
179579-2	1976	This enzymatic activity is strongly stimulated by NaF and 5"-guanylimidodiphosphate, is slightly stimulated by epinephrine, norepinephrine, isoproterenol, and prostaglandin E1 and is inhibited by calcium.	Alprostadil	159-175	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
1062433-0	1976	Floride uptake by root dentin after immersion in 2% NaF solution with iontophoresis.	floride	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
1225875-4	1975	Fluoride clearance was significantly slower after cetylaminefluoride rinses than after NaF rinses.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
1225875-5	1975	Prerinsing with sodium lauryl sulfate or cetylaminechloride annihilated the F clearance superiority of cetylaminefluoride over NaF.	Sodium Dodecyl Sulfate	16-37	C-X-C motif chemokine ligand 8	Homo sapiens	127-130
1032054-2	1976	Administration of NaF, NaCl, and mammalian calcitonin resulted in varying degree of hypolcalcaemia and hyperphosphataemia, whereas hypercalcaemia and hypophosphataemia developed during CaCl2 treatment.	Calcium Chloride	185-190	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
1067527-9	1976	The highest F-uptake was observed when a fluoride varnish, Duraphat (5% NaF) was applied three times at one weeks" interval.	Fluorides	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
1067527-9	1976	The highest F-uptake was observed when a fluoride varnish, Duraphat (5% NaF) was applied three times at one weeks" interval.	sodium fluoride topical preparation	59-67	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
1029317-0	1976	[Serum fluoride level in the NaF treatment of osteoporosis].	Fluorides	7-15	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
5277704-0	1970	The fluoride uptake by the enamel of human teeth "in vitro" after immersion in 2 per cent NaF solution with iontophoresis.	Fluorides	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
167852-7	1975	The data is rationalized by the postulation of two independent enzyme components in brain cortex: one component is about six-fold activated by NaF and the NaF effect is enhanced by low concentrations of Ca2+ and Mg2+.	magnesium ion	212-216	C-X-C motif chemokine ligand 8	Homo sapiens	155-158
167852-10	1975	On this basis, Triton X-100 treatment results in about a three-fold increase in specific activity of the Ca2+ dependent cyclase component but a complete abolition of the NaF stimulated component.	Octoxynol	15-27	C-X-C motif chemokine ligand 8	Homo sapiens	170-173
238919-1	1975	A new telemetric system was used to determine, simultaneously, plaque pH and salivary fluoride when sucrose-containing fluoride tablets of 0.25 mg and 1.0 mg NaF were dissolved in the oral cavity.	Sucrose	100-107	C-X-C motif chemokine ligand 8	Homo sapiens	158-161
165496-3	1975	In 5-fluorouracil and 5-chlorouracil, however, the halogen is evidently abstracted by the Na to form NaF or NaC1 and the neutral uracil radical.	Fluorouracil	3-17	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
165496-3	1975	In 5-fluorouracil and 5-chlorouracil, however, the halogen is evidently abstracted by the Na to form NaF or NaC1 and the neutral uracil radical.	5-chlorouracil	22-36	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
165496-3	1975	In 5-fluorouracil and 5-chlorouracil, however, the halogen is evidently abstracted by the Na to form NaF or NaC1 and the neutral uracil radical.	Halogens	51-58	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
4703037-0	1973	The effects of 0.05 to 5.0 mM NaF on calcium phosphate mineral accretion and subsequent acid dissolution at enamel surfaces.	calcium phosphate	37-54	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
5284490-0	1971	[Fluoride excretion in urine following administration of NaF and CaF 2  tablets].	Fluorides	1-9	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
5277132-0	1971	A method for in vitro studies of enamel fluoride uptake in single tooth surfaces with reference to NaF, NaF-H3PO4 and Na2SnF6.	Fluorides	40-48	C-X-C motif chemokine ligand 8	Homo sapiens	104-107
5458884-1	1970	Tablets of prednisolone-promethazine 40mg--25mg NAF].	prednisolone-promethazine	11-36	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
235523-3	1975	The 32P labeling of this component increased several fold when NaF was included in the incubation medium.	Phosphorus-32	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
4202670-12	1974	Blood collected in EDTA-47 mM NaF had a stable, reproducible UBBC with no significant in vitro increment with time.EDTA-NaF UBBC was 640+/-168 (range 380-921 pg B(12) bound/ml plasma) for 12 normal adult men and 809+/-232 (range 505-1208) for normal adult women.	ubbc	61-65	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
4202670-12	1974	Blood collected in EDTA-47 mM NaF had a stable, reproducible UBBC with no significant in vitro increment with time.EDTA-NaF UBBC was 640+/-168 (range 380-921 pg B(12) bound/ml plasma) for 12 normal adult men and 809+/-232 (range 505-1208) for normal adult women.	ubbc	124-128	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
4641417-6	1972	Inhibition of triglyceride hydrolysis was observed when postheparin plasma was preincubated in 2 m NaCl, 10(-4) m protamine, 10 mm Na(4)P(2)O(7), and 0.1 m NaF.	Triglycerides	14-26	C-X-C motif chemokine ligand 8	Homo sapiens	156-159
4322665-12	1971	The activity was increased by NaF and by prostaglandin PGE(1) and was decreased by epinephrine.	Epinephrine	83-94	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
5501055-14	1970	Following an 18-164 min perfusion period with 300 mM-NaF, the delayed K currents with 300 mM-KF were reduced in amplitude to less than one-tenth the initial level.	lysylphenylalanine	93-95	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
5501055-18	1970	In axons perfused with 300 mM-KF, following removal of the delayed rectifier by 300 mM-NaF, the ratio of steady-state Na current: peak Na current was estimated to be about half the value obtained with NaF.	lysylphenylalanine	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
5501055-18	1970	In axons perfused with 300 mM-KF, following removal of the delayed rectifier by 300 mM-NaF, the ratio of steady-state Na current: peak Na current was estimated to be about half the value obtained with NaF.	lysylphenylalanine	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	201-204
5229987-0	1966	NaF inhibition of the initial binding of aminoacyl-sRNA to reticulocyte ribosomes.	aminoacyl-srna	41-55	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
4237373-0	1968	ATP protection of myometrial adenosinetriphosphatase from the inhibitory effects of n-ethyl maleimide, urea and NaF.	Adenosine Triphosphate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	112-115
5982419-0	1966	[Behavior of calcemia, phosphoremia, calciuria, phosphaturia and alkaline phosphatase in normal subjects treated with sodium fluoride (NaF)].	Sodium Fluoride	118-133	C-X-C motif chemokine ligand 8	Homo sapiens	135-138
14238892-0	1964	REACTIONS OF NAF AND SNF2 WITH DENTAL ENAMEL HAVING VARYING CA:P RATIOS.	Phosphorus	63-64	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
13563565-2	1958	The division of cell potassium into two fractions during incubation with 0.025 M NaF.	Potassium	21-30	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
33581669-3	2021	This study aimed at exploring the role of sodium or other fluorides (NaF), which are intentionally added to flux-cored wire electrodes for stainless steel welding, on the solubility (in phosphate buffered saline) and toxicity of the generated welding fume particles.	Sodium	42-48	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
13245009-0	1955	[Acid solubility and fluorine content of dental enamel treated with NaF under different conditions; preliminary report].	Fluorine	21-29	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
33581669-3	2021	This study aimed at exploring the role of sodium or other fluorides (NaF), which are intentionally added to flux-cored wire electrodes for stainless steel welding, on the solubility (in phosphate buffered saline) and toxicity of the generated welding fume particles.	Fluorides	58-67	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
33581669-3	2021	This study aimed at exploring the role of sodium or other fluorides (NaF), which are intentionally added to flux-cored wire electrodes for stainless steel welding, on the solubility (in phosphate buffered saline) and toxicity of the generated welding fume particles.	Phosphate-Buffered Saline	186-211	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
33848541-10	2021	In contrast, the non-pairing of the Ibuprofen:Colistin and Ibuprofen:Tadim combinations showed a significant decrease in IL-8 secretion at both the concentrations.	Ibuprofen	36-45	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
33848541-10	2021	In contrast, the non-pairing of the Ibuprofen:Colistin and Ibuprofen:Tadim combinations showed a significant decrease in IL-8 secretion at both the concentrations.	Ibuprofen	59-68	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
33581669-6	2021	The welding fume particles containing NaF released significantly higher amounts of Cr(VI) compared with solid wire reference fumes, which was associated with increased cytotoxicity and genotoxicity in-vitro.	chromium hexavalent ion	83-89	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
33848541-10	2021	In contrast, the non-pairing of the Ibuprofen:Colistin and Ibuprofen:Tadim combinations showed a significant decrease in IL-8 secretion at both the concentrations.	tadim	69-74	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
33982762-3	2021	The results of ELISA and reverse transcription-quantitative PCR revealed that THCA reduced the secretion and mRNA expression levels of interleukin (IL)-6; IL-8; thymus and activation-regulated chemokine; macrophage-derived chemokine; regulated upon activation, normal T cell expressed and secreted; and monocyte chemoattractant protein-1 in TI mixture-stimulated HaCaT cells.	thca	78-82	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
33781846-11	2021	After independent confirmation, poly(I:C)-EVs upregulated BMP6 (p = 0.035) and flagellin-EVs upregulated CXCL8 (p = 0.005), VEGFA (p = 0.018) and PTGS2 (p = 0.020) compared to control-EVs.	flagellin-evs	79-92	C-X-C motif chemokine ligand 8	Homo sapiens	105-110
33934954-2	2021	In the current meta-analysis, we attempted to clarify the efficacy of curcumin/turmeric supplementation in reducing concentrations of interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha in patients with an inflammatory background.	Curcumin	70-78	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
33934954-3	2021	The main databases were searched to identify eligible trials evaluating the effect of curcumin in reducing IL-1, IL-6, IL-8, and TNF-alpha in serum up to March 2021.	Curcumin	86-94	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
33934954-7	2021	Nonetheless, curcumin/turmeric supplementation was non-significantly associated with reduced levels of IL-6 (WMD = -0.33 pg/ml, 95% CI = -0.99-0.34, P = 0.33) and increased levels of IL-8 (WMD = 0.52 pg/ml, 95% CI = -1.13-2.17, P = 0.53).	Curcumin	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
33934954-8	2021	The dose-responses analysis indicated that curcumin/turmeric supplementation resulted in IL-1 and IL-8 alteration in a non-linear model.	Curcumin	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
33683746-9	2021	Indeed, palmitate, a major free fatty acid with elevated plasma levels in diabetic patients, induced the expression of inflammatory cytokines found in the ocular fluid of DR patients such as CXCL8 (IL-8) and ANGPTL4.	Palmitates	8-17	C-X-C motif chemokine ligand 8	Homo sapiens	191-196
33683746-9	2021	Indeed, palmitate, a major free fatty acid with elevated plasma levels in diabetic patients, induced the expression of inflammatory cytokines found in the ocular fluid of DR patients such as CXCL8 (IL-8) and ANGPTL4.	Palmitates	8-17	C-X-C motif chemokine ligand 8	Homo sapiens	198-202
33683746-10	2021	Moreover, the analysis of palmitate-treated hiMGC secretome showed an upregulation of proangiogenic factors strongly related to DR, including ANG2, Endoglin, IL-1beta, CXCL8, MMP-9, PDGF-AA, and VEGF.	Palmitates	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	168-173
33930649-11	2021	The green tea extract and EGCG also had a dose-dependent inhibitory effect on irinotecan-induced secretion of interleukin-6 and interleukin-8 by oral epithelial cells.	epigallocatechin gallate	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	128-141
33895548-5	2021	Exogenous 17beta-estradiol (E2) stimulated endothelial exocytosis of Weibel-Palade bodies (WPBs), releasing von Willebrand factor (vWF) and interleukin-8 (IL-8).	Estradiol	10-26	C-X-C motif chemokine ligand 8	Homo sapiens	140-153
33895548-5	2021	Exogenous 17beta-estradiol (E2) stimulated endothelial exocytosis of Weibel-Palade bodies (WPBs), releasing von Willebrand factor (vWF) and interleukin-8 (IL-8).	Estradiol	10-26	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
33895548-5	2021	Exogenous 17beta-estradiol (E2) stimulated endothelial exocytosis of Weibel-Palade bodies (WPBs), releasing von Willebrand factor (vWF) and interleukin-8 (IL-8).	Estradiol	28-30	C-X-C motif chemokine ligand 8	Homo sapiens	140-153
33895548-5	2021	Exogenous 17beta-estradiol (E2) stimulated endothelial exocytosis of Weibel-Palade bodies (WPBs), releasing von Willebrand factor (vWF) and interleukin-8 (IL-8).	Estradiol	28-30	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
33930649-11	2021	The green tea extract and EGCG also had a dose-dependent inhibitory effect on irinotecan-induced secretion of interleukin-6 and interleukin-8 by oral epithelial cells.	Irinotecan	78-88	C-X-C motif chemokine ligand 8	Homo sapiens	128-141
33350460-6	2021	RESULTS: Among the 30 samples, the mean decrease in glucose levels was highest in the SSJ tube (0.38 mmol/L), followed by 0.16 mmol/L in Na citrate tube and 0.14 mmol/L in NaF-KOx tube.	Glucose	52-59	C-X-C motif chemokine ligand 8	Homo sapiens	172-175
33781652-0	2021	Glycosaminoglycans located on neutrophils and monocytes impact on CXCL8- and CCL2-induced cell migration.	Glycosaminoglycans	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	66-71
33781652-4	2021	Subsequent analysis of CXCL8- and CCL2-induced chemotaxis revealed that leukocyte migration was strongly reduced after eliminating heparan sulfate from the surface of neutrophils and monocytes.	Heparitin Sulfate	131-146	C-X-C motif chemokine ligand 8	Homo sapiens	23-28
33604932-0	2021	The role of IL-8 in skin lesions of a patient with erythema elevatum diutinum.	diutinum	69-77	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
33857626-2	2021	Although induction of death receptor-initiated extrinsic apoptosis by sodium fluoride (NaF) has been reported, its mechanism of action is still not clearly defined.	Sodium Fluoride	70-85	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
33857626-7	2021	Notably, we demonstrated that NaF could induce a significant increase in intracellular reactive oxygen species (ROS) level derived from nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4).	Reactive Oxygen Species	87-110	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
33857626-7	2021	Notably, we demonstrated that NaF could induce a significant increase in intracellular reactive oxygen species (ROS) level derived from nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4).	Reactive Oxygen Species	112-115	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
33857626-8	2021	Specifically, NOX4 knockdown inhibited NaF-induced the activation of p53/DR5 axis by reducing NOX4-derived ROS production.	Reactive Oxygen Species	107-110	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
33857626-9	2021	Further in vivo investigation demonstrated that NOX4 deficiency markedly attenuates NaF-induced lung injury, apoptosis, and ROS levels in the lung.	Reactive Oxygen Species	124-127	C-X-C motif chemokine ligand 8	Homo sapiens	84-87
33677254-0	2021	Tumor-associated macrophages-mediated CXCL8 infiltration enhances breast cancer metastasis: Suppression by Danirixin.	danirixin	107-116	C-X-C motif chemokine ligand 8	Homo sapiens	38-43
33677254-6	2021	Then, we showed that TAMs-released CXCL8 could markedly elevate the migration, invasion and EMT events in breast cancer cells, as well as the self-renewal of BCSCs in vitro.	tams	21-25	C-X-C motif chemokine ligand 8	Homo sapiens	35-40
33677254-8	2021	Consistently, the in vivo analysis confirmed that CXCL8 suppression using Danirixin effectively reduced the tumor growth, lung metastasis and repressed the self-renewal of BCSCs.	danirixin	74-83	C-X-C motif chemokine ligand 8	Homo sapiens	50-55
33677254-9	2021	Collectively, TAMs/CXCL8 could enhance BCSCs self-renewal and breast cancer metastasis, and these effects could be markedly abolished by Danirixin treatment, suppressing breast cancer progression consequently.	danirixin	137-146	C-X-C motif chemokine ligand 8	Homo sapiens	19-24
34036759-0	2021	Loading of capsaicin-in-cyclodextrin inclusion complexes into PEGylated liposomes and the inhibitory effect on IL-8 production by MDA-MB-231 and A549 cancer cell lines.	capsaicin-in-cyclodextrin	11-36	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
33830449-0	2021	Ellagitannins from Rosa roxburghii suppress poly(I:C)-induced IL-8 production in human keratinocytes.	Hydrolyzable Tannins	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
33830449-0	2021	Ellagitannins from Rosa roxburghii suppress poly(I:C)-induced IL-8 production in human keratinocytes.	Poly I-C	44-53	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
33830449-2	2021	The RRFE inhibited interleukin-8 (IL-8) mRNA expression in normal human epidermal keratinocytes (NHEKs) stimulated with polyinosinic:polycytidylic acid (poly(I:C)), a ligand of toll-like receptor-3 (TLR-3).	polyinosinic	120-132	C-X-C motif chemokine ligand 8	Homo sapiens	19-32
33830449-2	2021	The RRFE inhibited interleukin-8 (IL-8) mRNA expression in normal human epidermal keratinocytes (NHEKs) stimulated with polyinosinic:polycytidylic acid (poly(I:C)), a ligand of toll-like receptor-3 (TLR-3).	polyinosinic	120-132	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
33830449-4	2021	The purified compounds, strictinin and casuarictin, inhibited the IL-8 mRNA expression and IL-8 release induced in NHEKs by poly(I:C).	strictinin	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
33830449-4	2021	The purified compounds, strictinin and casuarictin, inhibited the IL-8 mRNA expression and IL-8 release induced in NHEKs by poly(I:C).	strictinin	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
33639259-1	2021	OBJECTIVE: Molecular information derived from dynamic [18F]sodium fluoride ([18F]NaF) PET imaging holds promise as a quantitative marker of bone metabolism.	[18f]sodium fluoride	54-74	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
33843989-12	2021	Therefore, in a high-glucose environment, IL-8 activated the Akt signaling pathway, promoted paracrine mechanisms of BMSCs, and improved the proliferation and migration of HUVECs.	Glucose	21-28	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
33830449-4	2021	The purified compounds, strictinin and casuarictin, inhibited the IL-8 mRNA expression and IL-8 release induced in NHEKs by poly(I:C).	casuarictin	39-50	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
33830449-4	2021	The purified compounds, strictinin and casuarictin, inhibited the IL-8 mRNA expression and IL-8 release induced in NHEKs by poly(I:C).	casuarictin	39-50	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
33830449-4	2021	The purified compounds, strictinin and casuarictin, inhibited the IL-8 mRNA expression and IL-8 release induced in NHEKs by poly(I:C).	Poly I-C	124-133	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
33830449-4	2021	The purified compounds, strictinin and casuarictin, inhibited the IL-8 mRNA expression and IL-8 release induced in NHEKs by poly(I:C).	Poly I-C	124-133	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
33846813-8	2021	Furthermore, the results also revealed a decrease in IL1B-induced IL8, MMP-1, and MMP-9 expression in response to celastrol treatment.	celastrol	114-123	C-X-C motif chemokine ligand 8	Homo sapiens	66-69
34057209-11	2021	Long-term exposure of HGFs to nicotine or CSC significantly suppressed their cellular proliferation and migration and upregulated type I collagen, type III collagen, interleukin (IL)-6, IL-8, p16, p21, and p53 mRNA expression, and IL-6 and IL-8 protein expression.	Nicotine	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
34057209-11	2021	Long-term exposure of HGFs to nicotine or CSC significantly suppressed their cellular proliferation and migration and upregulated type I collagen, type III collagen, interleukin (IL)-6, IL-8, p16, p21, and p53 mRNA expression, and IL-6 and IL-8 protein expression.	Nicotine	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	240-244
34050537-5	2022	Particles comprising high copper (Cu) and zinc (Zn) content activated human endothelial cells via a non-ROS-mediated mechanism that triggered immune activation (IL-8, GM-CSF), leukocyte adhesion to the endothelium (soluble intercellular adhesion molecule 1 (sICAM-1)), and secretion of regulators of the acute-phase protein synthesis (interleukin 6 (IL-6)).	Copper	34-36	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
34050537-5	2022	Particles comprising high copper (Cu) and zinc (Zn) content activated human endothelial cells via a non-ROS-mediated mechanism that triggered immune activation (IL-8, GM-CSF), leukocyte adhesion to the endothelium (soluble intercellular adhesion molecule 1 (sICAM-1)), and secretion of regulators of the acute-phase protein synthesis (interleukin 6 (IL-6)).	Zinc	48-50	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
34033222-2	2021	We investigated whether use of reparixin for blockade of the CXCL8 pathway would improve islet engraftment and insulin independence after TPIAT.	reparixin	31-40	C-X-C motif chemokine ligand 8	Homo sapiens	61-66
33689220-3	2021	Herein, a low-cost 19 m (m: mol kg -1) bi-salts WISE with a wide ESW of 2.8 V was designed, where the low-cost 17 m NaClO4 extends the anodic limiting potential to 4.4 V, while the fluorine-containing salt (2 m NaOTF) extends the cathodic limiting potential to 1.6 V by forming a NaF-Na2O-NaOH SEI on anodes.	bi-salts	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	280-283
34030480-9	2021	Moreover, Poly(I:C)-HMW/LyoVec and Poly(I:C)-HMW were the only ligands that significantly increased IL-8 secretion.	Poly I-C	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
34030480-10	2021	Interestingly, HBV infection reduced IL-8 secretion induced by Poly(I:C)-HMW and to a lesser extent Poly(I:C)-HMW/LyoVec.	Poly I-C	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
34006909-9	2021	The integration of metabolic and immune data indicated a molecular signature constituted by IL-6, IL1-ra, DMG, CCL4, Ile, Gly and IL-8, which could discriminate patients and healthy subjects and could represent a candidate tool in the diagnosis of new-onset psoriasis.	dimethylglycine	106-109	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
34018029-11	2021	Among patients with IRRs, those receiving ibrutinib-obinutuzumab had lower post-obinutuzumab increases in IL-6, IL-8, IL-10, and MCP-1 (P < 0.04) than patients receiving chlorambucil-obinutuzumab.	ibrutinib	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
34020271-3	2021	Our previous work has confirmed that premature senescent hepatocytes induced by Cr(VI) expressed high level of Clusterin (CLU) and secrete interleukin-6 (IL-6) and IL-8.	chromium hexavalent ion	80-86	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
34020271-5	2021	In this study we demonstrated that Cr(VI) induced the secretion of tumor promoting components of SASP such as IL-6, IL-8, and granulocyte-macrophage colony stimulating factor (GM-CSF) in senescent L-02 hepatocytes, while the levels of the anti-tumor components of SASP such as chemokine (c-x-c motif) ligand-1 (CXCL-1) and monocyte chemoattractant protein-1 (MCP-1) were not altered.	chromium hexavalent ion	35-41	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
34020271-7	2021	The NF-kappaB inhibitor PDTC significantly alleviated Cr(VI)-induced increase of IL-6, IL-8, and GM-CSF, confirming that NF-kappaB can regulate the tumor promoting components of SASP.	prolinedithiocarbamate	24-28	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
34020271-7	2021	The NF-kappaB inhibitor PDTC significantly alleviated Cr(VI)-induced increase of IL-6, IL-8, and GM-CSF, confirming that NF-kappaB can regulate the tumor promoting components of SASP.	chromium hexavalent ion	54-60	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
34001091-8	2021	Time course studies showed that ORMDL3-deficient A549 and NHBE cells had an attenuated IL-6 and IL-8 response to poly I:C stimulation.	Poly I-C	113-121	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
33689220-3	2021	Herein, a low-cost 19 m (m: mol kg -1) bi-salts WISE with a wide ESW of 2.8 V was designed, where the low-cost 17 m NaClO4 extends the anodic limiting potential to 4.4 V, while the fluorine-containing salt (2 m NaOTF) extends the cathodic limiting potential to 1.6 V by forming a NaF-Na2O-NaOH SEI on anodes.	sodium perchlorate	116-122	C-X-C motif chemokine ligand 8	Homo sapiens	280-283
33993290-9	2021	The A2B agonist BAY60-6583 significantly elevated levels of IL6 and CXCL8, a result also obtained with adenosine and its analogue NECA.	BAY 60-6583	16-26	C-X-C motif chemokine ligand 8	Homo sapiens	68-73
33989405-6	2021	Conditions of 60 mM glucose potentiated secretion of the cytokine IL-8 suggesting that cytokine secretion during hyperglycemia may be a source of tissue inflammation.	Glucose	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
33675827-7	2021	The loading of LVOX into CH/ZA induced its anti-inflammatory effect against the cytokine production (IL-6 and IL-8) within the human bronchial epithelia cells (NL20).	Levofloxacin	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
33989405-7	2021	TNFalpha measurably increased secretion of IL-8 and IL-1beta, which was enhanced at 60 mM glucose.	Glucose	90-97	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
34007158-9	2021	FTY720 reduced the secretion of IL-1beta, IL-6, and IL-8 from TNF-alpha-stimulated MH7A cells in a dose-dependent manner.	Fingolimod Hydrochloride	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
33990437-8	2021	PSB reduced postoperative inflammatory response by limiting concentrations of proinflammatory cytokines IL-8, IL-18, IL-23, IL-33 and MCP-1 measured in the first 7-day after surgery (p<0.05).	psb	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
33958662-6	2021	Both epoxygenated fatty acids significantly decreased IL-8 expression in IL-1beta-induced MC and TNFalpha in PA-induced MC.	epoxygenated fatty acids	5-29	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
34040530-15	2021	Upstream regulators of cathine and cathinone were found to potentially target several molecules including interleukin-8, MMP2, PLAU, and micro-RNAs.	norpseudoephedrine	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	106-119
34040530-15	2021	Upstream regulators of cathine and cathinone were found to potentially target several molecules including interleukin-8, MMP2, PLAU, and micro-RNAs.	cathinone	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	106-119
33964033-13	2021	Fluvastatin reduced IL8, IL6, CCL21, AQP9 (p<0.001) and MMP9 (p<0.05) in the ex-vivo pulpitis model, while dequalinium chloride reduced AQP9 (p<0.001) but had no significant effect on the other biomarkers.	Fluvastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	20-23
33960079-3	2021	Among them, GCP-1 (Cycle-(Trp-Glu-His-Thr)) inhibited proliferation and induced human cervical cancer (HeLa) cells apoptosis and blocked the HeLa cells in G0/G1 phase significantly.	Tryptophan	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	12-17
33960079-3	2021	Among them, GCP-1 (Cycle-(Trp-Glu-His-Thr)) inhibited proliferation and induced human cervical cancer (HeLa) cells apoptosis and blocked the HeLa cells in G0/G1 phase significantly.	Glu-His	30-37	C-X-C motif chemokine ligand 8	Homo sapiens	12-17
33960079-3	2021	Among them, GCP-1 (Cycle-(Trp-Glu-His-Thr)) inhibited proliferation and induced human cervical cancer (HeLa) cells apoptosis and blocked the HeLa cells in G0/G1 phase significantly.	Threonine	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	12-17
33960079-5	2021	Moreover, GCP-1 suppressed the cyclin expression and activated the caspase cascade and poly(ADP-ribose) polymerase.	Poly Adenosine Diphosphate Ribose	87-103	C-X-C motif chemokine ligand 8	Homo sapiens	10-15
33950330-1	2021	To examine 2-year changes in carotid and aortic 18F-sodium fluoride (NaF) uptake in both healthy controls and angina pectoris patients.	18f-sodium fluoride	48-67	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
33949204-8	2021	p55PIK deficiency and TAT-N15 significantly inhibited the cigarette smoke extract-induced IL-6, IL-8, and activation of the Akt and the NF-kappaB pathway in BEAS-2B.	tat-n15	22-29	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
33421881-6	2021	The levels of interleukin (IL)-1beta, IL-6, IL-8 and IL-13 were about 1.5 times higher in the PFOA-treated A549 and L-02 cells than in the controls.	perfluorooctanoic acid	94-98	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
33421881-8	2021	Arginine and vitamin B6 supplemented into cell culture effectively decreased the levels of IL-6 and IL-8.	Arginine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
33421881-8	2021	Arginine and vitamin B6 supplemented into cell culture effectively decreased the levels of IL-6 and IL-8.	Vitamin B 6	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
33947432-0	2021	Correction to: Genistein inhibits stemness of SKOV3 cells induced by macrophages co-cultured with ovarian cancer stem-like cells through IL-8/STAT3 axis.	Genistein	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
32697835-6	2021	E2 levels were negatively correlated with IL-2R, IL-6, IL-8 and TNFalpha in luteal phase (Pearson Correlation=-0.592, -0.558, -0.545, -0.623; p=0.033, 0.048, 0.054, 0.023), and with C3 in follicular phase (Pearson Correlation=-0.651; p=0.030).	Estradiol	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
33484111-6	2021	MP and SP groups were significantly different in terms of IL8, IL10 and sSELE levels.	6-trimethylsilylthio-9-trimethylsilylpurine	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
33947407-12	2021	DISCUSSION: Our study revealed elevated plasma levels of inflammatory mediators in different PAH subgroups and CTEPH at baseline and at 1-year follow-up, whereby CXCL9 and IL-8 may prove to be prognostic markers for CTEPH patients.	cteph	216-221	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
33484111-6	2021	MP and SP groups were significantly different in terms of IL8, IL10 and sSELE levels.	sp	7-9	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
33550164-7	2021	We found that TNF-alpha, IL-1beta, IL-6, and IL-8 were the four immune mediators that elevated in most of the samples derived from patients with CP/CPPS and the EAP models.	phosphorylethanolamine	161-164	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
33222241-4	2021	RESULTS: Levels of IL-16, CXCL8, CXCL10, CCL17, and CCL22 were significantly increased in reactions (1+, 2+) to thiurams and fragrances compared to their petrolatum controls, except for PT reactions to FM I/II with negative breakdown testing in which, however, decreased levels of NMF were observed.	Thiram	112-120	C-X-C motif chemokine ligand 8	Homo sapiens	26-31
33144047-10	2021	On the contrary, RHE treated with PM or TS after preconditioning by a semi-dry airflow show a lower increase in IL-1alpha, IL-8, and RANTES compared to preconditioning by a humid airflow.	Promethium	34-36	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
33176493-8	2021	Besides, we found correlations of interleukin-8 with age, glucose, and lipid profile in the overfat group.	Glucose	58-65	C-X-C motif chemokine ligand 8	Homo sapiens	34-47
33091430-8	2021	In contrast, bisphenols significantly reduced the production of CXCL8/IL-8 by neutrophils, an effect found to be greater with the glucuronidated metabolites.	bis(4-hydroxyphenyl)sulfone	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	64-69
33091430-8	2021	In contrast, bisphenols significantly reduced the production of CXCL8/IL-8 by neutrophils, an effect found to be greater with the glucuronidated metabolites.	bis(4-hydroxyphenyl)sulfone	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
33747166-6	2021	In comparison with the control group, patients in the Dex group exhibited a significant increase in cardiac function, as indicated by an increase in HR, MAP and IL-10 levels, and a significant decrease in cTnI, IL-8, MDA and glucose levels.	Dexmedetomidine	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	211-215
33649784-11	2021	The pharmacological induction of autophagy with rapamycin or metformin attenuated the pro-migratory effects of IL-8.	Sirolimus	48-57	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
33649784-11	2021	The pharmacological induction of autophagy with rapamycin or metformin attenuated the pro-migratory effects of IL-8.	Metformin	61-70	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
33649784-12	2021	Neutralizing anti-IL-8 antibody counteracted the inhibitory effect of OVCAF-CM on basal autophagy.	ovcaf-cm	70-78	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
33596158-0	2021	l-Cysteine Stimulates the Effect of Vitamin D on Inhibition of Oxidative Stress, IL-8, and MCP-1 Secretion in High Glucose Treated Monocytes.	Cysteine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
31914352-9	2021	There was significant positive correlation between serum vitamin D and Th1 cytokines IL-2 and IL-8 as well as Th2 cytokines (ILs-3, 4, 5 and 9), but negative correlation with IL-13Conclusions: Serum Vitamin D and cytokines were lower in a sample of Nigerian children with asthma than controls.	Vitamin D	57-66	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
33596158-0	2021	l-Cysteine Stimulates the Effect of Vitamin D on Inhibition of Oxidative Stress, IL-8, and MCP-1 Secretion in High Glucose Treated Monocytes.	Vitamin D	36-45	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
33596158-3	2021	This study examined the hypothesis that supplementation with vitamin D, in combination with l-cysteine (LC), is better at reducing oxidative stress and thereby, more effective, at inhibiting the secretion of the pro-inflammatory cytokines, Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in U937 monocytes exposed to high glucose concentrations.	Vitamin D	61-70	C-X-C motif chemokine ligand 8	Homo sapiens	240-253
33596158-3	2021	This study examined the hypothesis that supplementation with vitamin D, in combination with l-cysteine (LC), is better at reducing oxidative stress and thereby, more effective, at inhibiting the secretion of the pro-inflammatory cytokines, Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in U937 monocytes exposed to high glucose concentrations.	Vitamin D	61-70	C-X-C motif chemokine ligand 8	Homo sapiens	255-259
33596158-3	2021	This study examined the hypothesis that supplementation with vitamin D, in combination with l-cysteine (LC), is better at reducing oxidative stress and thereby, more effective, at inhibiting the secretion of the pro-inflammatory cytokines, Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in U937 monocytes exposed to high glucose concentrations.	Cysteine	104-106	C-X-C motif chemokine ligand 8	Homo sapiens	240-253
33596158-3	2021	This study examined the hypothesis that supplementation with vitamin D, in combination with l-cysteine (LC), is better at reducing oxidative stress and thereby, more effective, at inhibiting the secretion of the pro-inflammatory cytokines, Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in U937 monocytes exposed to high glucose concentrations.	Cysteine	104-106	C-X-C motif chemokine ligand 8	Homo sapiens	255-259
33219895-8	2021	Furthermore, we detected elevated levels of IL-8, IL-6, and TNF-alpha in EH patients could activate platelets/ECs and induce elevated PS exposure on their membranes.	Phosphatidylserines	134-136	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
33711406-1	2021	OBJECTIVE: To examine the biochemical components of multi-species biofilm on the arginine (Arg)-sodium fluoride (NaF) varnish-treated enamel following bacterial pH-cycling.	Arginine	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
33711406-1	2021	OBJECTIVE: To examine the biochemical components of multi-species biofilm on the arginine (Arg)-sodium fluoride (NaF) varnish-treated enamel following bacterial pH-cycling.	Arginine	91-94	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
33711406-1	2021	OBJECTIVE: To examine the biochemical components of multi-species biofilm on the arginine (Arg)-sodium fluoride (NaF) varnish-treated enamel following bacterial pH-cycling.	Sodium Fluoride	96-111	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
33711406-4	2021	The experimental and control groups were: 1%, 2%, 4% Arg-NaF, NaF, and no treatment.	Arginine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
33711406-8	2021	RESULTS: The total carbohydrate content of the biofilm was the lowest for the 2% and 4% Arg-NaF (p < 0.05).	Carbohydrates	19-31	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
33711406-8	2021	RESULTS: The total carbohydrate content of the biofilm was the lowest for the 2% and 4% Arg-NaF (p < 0.05).	Arginine	88-91	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
33711406-9	2021	Except for 2% Arg-NaF, the biofilm proteins for 4% Arg-NaF were significantly higher than the other groups (p < 0.05).	Arginine	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
33711406-9	2021	Except for 2% Arg-NaF, the biofilm proteins for 4% Arg-NaF were significantly higher than the other groups (p < 0.05).	Arginine	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
33711406-10	2021	The amyloids for Arg-NaF groups were significantly lower than the controls (p < 0.05).	Arginine	17-20	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
33711406-11	2021	The eDNA for 4% Arg-NaF was significantly higher than the controls (p < 0.05).	Arginine	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	20-23
33711406-12	2021	The 2% and 4% Arg-NaF-treated enamel had increased biofilm Pi and F compared to the NaF-treated enamel (p < 0.05).	Arginine	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
33711406-13	2021	The proportion of biofilm EPS matrix to bacteria was significantly reduced in Arg-NaF groups compared to the controls (p < 0.05).	eps	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
33711406-13	2021	The proportion of biofilm EPS matrix to bacteria was significantly reduced in Arg-NaF groups compared to the controls (p < 0.05).	Arginine	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
33711406-14	2021	The dead bacterial proportions of 4% Arg-NaF were significantly higher than the controls (p < 0.05).	Arginine	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
33711406-15	2021	CONCLUSION: Higher concentrations (i.e. 2%/4%) of Arg in 5% NaF varnish have the potential to modulate the biochemical composition of the biofilm growing on the treated enamel.	Arginine	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
33760117-11	2021	Inhibition of CXCL8 in combination with miR-302c-3p and/or miR-520a-3p overexpression exerted proliferation-suppressive and apoptosis-stimulating effects on CC cells, whereas restoring CXCL8 attenuated the miR-302c-3p- and miR-520a-3p-induced anti-proliferative and pro-apoptotic effects.	mir-302c-3p	206-217	C-X-C motif chemokine ligand 8	Homo sapiens	14-19
33632872-2	2021	Surprisingly though, DCs cultured in the presence of supernatant derived from VPA-treated cancer cells showed a reduced allostimulatory capacity and an increased release of IL-10 and IL-8 cytokines in comparison to those exposed to TSA-treated cells culture supernatant.	Valproic Acid	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
33760162-0	2021	Escin inhibits angiogenesis by suppressing interleukin-8 and vascular endothelial growth factor production by blocking nuclear factor-kappaB activation in pancreatic cancer cell lines.	Escin	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	43-56
33576698-7	2021	ZnO NPs delivered at 1.0 microg/cm2 in the NACIVT system, mimicking occupational exposure, induced significant increases in metabolic activity and release of the cytokines IL-8 and MCP-1, but no differences were observed using traditional exposures.	Zinc Oxide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
33576698-7	2021	ZnO NPs delivered at 1.0 microg/cm2 in the NACIVT system, mimicking occupational exposure, induced significant increases in metabolic activity and release of the cytokines IL-8 and MCP-1, but no differences were observed using traditional exposures.	nacivt	43-49	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
33760162-8	2021	Furthermore, ELISA confirmed that NF-kappaB activity in the escin-treated PaCa cells was significantly inhibited and reverse transcription-quantitative PCR showed that the mRNA expression levels of tumor necrosis factor-alpha-induced IL-8 and VEGF were significantly suppressed following escin treatment in the PaCa cell lines.	Escin	288-293	C-X-C motif chemokine ligand 8	Homo sapiens	234-238
34033999-0	2021	Sulforaphane inhibits the expression of interleukin-6 and interleukin-8 induced in bronchial epithelial IB3-1 cells by exposure to the SARS-CoV-2 Spike protein.	sulforaphane	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	58-71
34035660-8	2021	Results: In IL-1beta-primed cells, preincubation with Vanillin reduced IL-6, IL-8, COX-2, and iNOS expression and NO release, compared to IL-1beta-primed cells.	vanillin	54-62	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
34035660-10	2021	Furthermore, in presence of mechanical injury, the Vanillin preincubation, wound closure may be reducing the expression and release of IL-6 and TNF-alpha and upregulation of COX-2 and IL-8.	vanillin	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
33760162-9	2021	ELISA also showed that escin decreased the secretion of IL-8 and VEGF from the PaCa cells.	Escin	23-28	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
33760162-8	2021	Furthermore, ELISA confirmed that NF-kappaB activity in the escin-treated PaCa cells was significantly inhibited and reverse transcription-quantitative PCR showed that the mRNA expression levels of tumor necrosis factor-alpha-induced IL-8 and VEGF were significantly suppressed following escin treatment in the PaCa cell lines.	Escin	60-65	C-X-C motif chemokine ligand 8	Homo sapiens	234-238
33760162-11	2021	These results indicated that escin inhibited angiogenesis by reducing the secretion of IL-8 and VEGF by blocking NF-kappaB activity in PaCa.	Escin	29-34	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
33893805-5	2022	To one of the aliquots sodium fluoride (NaF, 1% w/v) was added.	Sodium Fluoride	23-38	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
33984751-10	2021	Interaction network construction and topological analysis yielded 60 hub targets, of which 18 were major hub targets, among which IL-6, IL-8, TNF, PI3K, MAPK, and NF-kappaB (RELA) are the most important in LYT"s treatment of AAD-induced MetS.	L-2-Aminoadipic acid	225-228	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
33876932-0	2021	Kosmotropic Electrolyte (Na2CO3, NaF) Perturbs the Air/Water Interface through Anion Hydration Shell without Forming a Well-Defined Electric Double Layer.	Water	55-60	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
33876932-2	2021	By combining heterodyne-detected vibrational sum frequency generation (HD-VSFG) with differential spectroscopy involving simultaneous curve fitting (DS-SCF) analysis, we retrieve electrolyte (Na2CO3 and NaF)-correlated OH-stretch spectra of water at the air/water interface.	Water	241-246	C-X-C motif chemokine ligand 8	Homo sapiens	203-206
33876932-2	2021	By combining heterodyne-detected vibrational sum frequency generation (HD-VSFG) with differential spectroscopy involving simultaneous curve fitting (DS-SCF) analysis, we retrieve electrolyte (Na2CO3 and NaF)-correlated OH-stretch spectra of water at the air/water interface.	Water	258-263	C-X-C motif chemokine ligand 8	Homo sapiens	203-206
33987174-6	2021	More specifically, chloroquine elution down-regulates interleukin 8 (IL-8) and matrix metalloproteinase nine secretion while up-regulating hepatocyte growth factor, vascular endothelial growth factor A, and IL-22 secretion, suggesting a potential shift toward a resolving neutrophil phenotype.	Chloroquine	19-30	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
33987174-6	2021	More specifically, chloroquine elution down-regulates interleukin 8 (IL-8) and matrix metalloproteinase nine secretion while up-regulating hepatocyte growth factor, vascular endothelial growth factor A, and IL-22 secretion, suggesting a potential shift toward a resolving neutrophil phenotype.	Chloroquine	19-30	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
33899586-9	2021	Interestingly; the over expression of Nrf2 using Nrf2-Ad-WT or Sulforaphane was also associated with significant upregulation of IL-8 compared to controls.	sulforaphane	63-75	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
33913531-1	2021	The aim of this study was to assess the modulatory effect of TcpA in the expression of CEACAM1 adhesin molecule and IL-1, IL-8 and TNFalpha pro-inflammatiory cytokines in the co-culture model of Caco-2/PBMC that can mimic the intestinal milieu.	chlorfenac	61-65	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
33913531-9	2021	In conclusion, V.cholerae TcpA induces statistically significant dose-dependent stimulatory effect on TNFalpha, IL-1 and IL-8 pro-inflammatory cytokines expression.	chlorfenac	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
33900421-4	2021	IL6-174 GC and IL8-251 T allele showed a protective effect in women against ACG development and, conversely, IL8-251 polymorphism showed a risk for men.	acg	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
33923126-1	2021	ACRIN 6687, a multi-center clinical trial evaluating differential response of bone metastases to dasatinib in men with metastatic castration-resistant prostate cancer (mCRPC), used [18F]-fluoride (NaF) PET imaging.	acrin 6687	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	197-200
33923126-8	2021	Pharmacodynamic changes with dasatinib in tumor bone can be identified by WB NaF PET in men with mCRPC.	Dasatinib	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
33903806-7	2021	In the case of GCF, taurine levels were positively correlated with IL-8 levels in both groups (all P < 0.05).	Taurine	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
33893193-1	2022	Coronary 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) and computed tomography (CT) angiography-based quantitative plaque analysis have shown promise in refining risk stratification in patients with coronary artery disease.	18f-sodium fluoride	9-28	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
33900308-6	2021	Syringic acid and kuromanin, standard compounds found in FBBBR, significantly decreased the interleukin (IL)-1beta, IL-6 and IL-8 levels in PM2.5-treated HaCaT cells.	syringic acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
33919366-2	2021	The current study addressed the question of how palmitate might interact with insulin or PGE2 to induce the formation of the chemotactic pro-inflammatory cytokine interleukin-8 (IL-8).	Palmitates	48-57	C-X-C motif chemokine ligand 8	Homo sapiens	163-176
33919366-2	2021	The current study addressed the question of how palmitate might interact with insulin or PGE2 to induce the formation of the chemotactic pro-inflammatory cytokine interleukin-8 (IL-8).	Palmitates	48-57	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
33919366-0	2021	Enhanced Palmitate-Induced Interleukin-8 Formation in Human Macrophages by Insulin or Prostaglandin E2.	Palmitates	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
33919366-0	2021	Enhanced Palmitate-Induced Interleukin-8 Formation in Human Macrophages by Insulin or Prostaglandin E2.	Dinoprostone	86-102	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
33919366-2	2021	The current study addressed the question of how palmitate might interact with insulin or PGE2 to induce the formation of the chemotactic pro-inflammatory cytokine interleukin-8 (IL-8).	Dinoprostone	89-93	C-X-C motif chemokine ligand 8	Homo sapiens	163-176
33900308-6	2021	Syringic acid and kuromanin, standard compounds found in FBBBR, significantly decreased the interleukin (IL)-1beta, IL-6 and IL-8 levels in PM2.5-treated HaCaT cells.	cyanidin 3-O-glucopyranoside	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
33919366-2	2021	The current study addressed the question of how palmitate might interact with insulin or PGE2 to induce the formation of the chemotactic pro-inflammatory cytokine interleukin-8 (IL-8).	Dinoprostone	89-93	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
33919366-4	2021	In these macrophages, palmitate induced IL-8 formation.	Palmitates	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
33919366-5	2021	Insulin enhanced the induction of IL-8 formation by palmitate as well as the palmitate-dependent stimulation of PGE2 synthesis.	Palmitates	52-61	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
33850164-5	2021	Cromolyn and a new fluorinated analog dramatically reduced the secretion of a wide spectrum of inflammatory mediators, which included cytokines such as IL-1beta, IL-6, IL-8 and IFN-gamma, and chemokines such as CXCL10, CCL2, CCL3 and CCL4.	Cromolyn Sodium	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
33919366-6	2021	PGE2 in turn elicited IL-8 formation on its own and enhanced the induction of IL-8 release by palmitate, most likely by activating the EP4 receptor.	Dinoprostone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
33919366-6	2021	PGE2 in turn elicited IL-8 formation on its own and enhanced the induction of IL-8 release by palmitate, most likely by activating the EP4 receptor.	Dinoprostone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
33919366-6	2021	PGE2 in turn elicited IL-8 formation on its own and enhanced the induction of IL-8 release by palmitate, most likely by activating the EP4 receptor.	Palmitates	94-103	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
33919366-7	2021	Since IL-8 causes insulin resistance and fosters inflammation, the increase in palmitate-induced IL-8 formation that is caused by hyperinsulinemia and locally produced PGE2 in chronically inflamed adipose tissue might favor disease progression in a vicious feed-forward cycle.	Palmitates	79-88	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
33919366-7	2021	Since IL-8 causes insulin resistance and fosters inflammation, the increase in palmitate-induced IL-8 formation that is caused by hyperinsulinemia and locally produced PGE2 in chronically inflamed adipose tissue might favor disease progression in a vicious feed-forward cycle.	Palmitates	79-88	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
33919366-7	2021	Since IL-8 causes insulin resistance and fosters inflammation, the increase in palmitate-induced IL-8 formation that is caused by hyperinsulinemia and locally produced PGE2 in chronically inflamed adipose tissue might favor disease progression in a vicious feed-forward cycle.	Dinoprostone	168-172	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
33882577-8	2021	A concentration-dependent significant increase in pro-inflammatory markers C-C motif chemokine ligand 2, interleukin (IL)6, and IL8 was observed for EB-exposed A549 cells compared to CA.	ethylbenzene	149-151	C-X-C motif chemokine ligand 8	Homo sapiens	128-131
33959001-11	2021	In MSCs, atorvastatin and aspirin combination reduced the release of pro-inflammatory cytokines such as IL-6, IL-8, MCP-1 and IFN-gamma.	Atorvastatin	9-21	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
33959001-11	2021	In MSCs, atorvastatin and aspirin combination reduced the release of pro-inflammatory cytokines such as IL-6, IL-8, MCP-1 and IFN-gamma.	Aspirin	26-33	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
33959001-12	2021	Atorvastatin alone reduced the release of IL-6, IL-8 and MCP-1 from co-cultures of stroke monocytes and MSCs.	Atorvastatin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
33921615-12	2021	In addition, lipoxin A4 inhibited the infiltration of neutrophils and the production of cytokines and pro-inflammatory chemokines, such as interleukin (Il-1beta, Il-6, Il-8) and tumor necrosis factor-alpha (TNF-alpha).	lipoxin A4	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
33857948-5	2021	Using flow cytometric methods, we determined that the IL-8-induced cellular activity was largely dependent on specific ion channels and transporters, such as the sodium-proton exchanger 1 (NHE1) and non-NHE1-dependent sodium flux.	Sodium	162-168	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
33857948-5	2021	Using flow cytometric methods, we determined that the IL-8-induced cellular activity was largely dependent on specific ion channels and transporters, such as the sodium-proton exchanger 1 (NHE1) and non-NHE1-dependent sodium flux.	Sodium	218-224	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
33855585-9	2022	CONCLUSION: IL-6 and IL-8 baseline values predicted outcomes of sorafenib-treated patients in this well-characterized prospective cohort of the SORAMIC trial.	Sorafenib	64-73	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
33854135-6	2021	We did find evidence of an increase in IL-8 production by epithelial cells with increasing bioavailable iron (p = 0.01), however, this was not linked to the pyrite content of the coal (p = 0.75) and we did not see any evidence of a positive association in the other cell types.	Iron	104-108	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
33887366-8	2021	Our findings demonstrated that these specific non-traditional biomarkers measured together with more conventional ones (e.g., CDT, EtG, IL8, ALT, AST, GGT) could represent novel key parameters for monitoring alcohol use disorders and withdrawal being also suggestive of the complexity of psychoneuroimmune response to alcohol.	Alcohols	208-215	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
33860869-10	2021	Further experiments revealed that S1-induced increase in the production of TNFalpha, IL-6, IL-1beta and IL-8 was reduced in the presence of BAY11-7082 and SKF 86002, while CRID3 pre-treatment resulted in the reduction of IL-1beta production.	3-(4-methylphenylsulfonyl)-2-propenenitrile	140-150	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
33860869-10	2021	Further experiments revealed that S1-induced increase in the production of TNFalpha, IL-6, IL-1beta and IL-8 was reduced in the presence of BAY11-7082 and SKF 86002, while CRID3 pre-treatment resulted in the reduction of IL-1beta production.	6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole	155-164	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
33860562-0	2021	5-Aminolaevulinic acid photodynamic therapy amplifies intense inflammatory response in the treatment of acne vulgaris via CXCL8.	Aminolevulinic Acid	0-22	C-X-C motif chemokine ligand 8	Homo sapiens	122-127
33860562-6	2021	Besides, ALA-PDT could up-regulate the expression of CXCL8 in vivo and in vitro, amplifying the inflammatory response by recruiting T cells, B cells, neutrophils and macrophages.	Alanine	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	53-58
33860562-7	2021	We also found that ALA-PDT elevated the expression of CXCL8 via p38 pathway.	Alanine	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	54-59
33860562-8	2021	SB203580, a p38 pathway inhibitor, decreased the expression of CXCL8 in sebocytes after ALA-PDT.	SB 203580	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	63-68
33860562-8	2021	SB203580, a p38 pathway inhibitor, decreased the expression of CXCL8 in sebocytes after ALA-PDT.	Alanine	88-91	C-X-C motif chemokine ligand 8	Homo sapiens	63-68
33860562-9	2021	These findings indicate that ALA-PDT amplifies the intense inflammatory response in treatment of acne vulgaris via CXCL8.	Alanine	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	115-120
33937285-5	2021	Among such class of drugs, azithromycin is described as azalide and is well-known for its ability to decrease the production of pro-inflammatory cytokines, including matrix metalloproteinases, tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8.	Azithromycin	27-39	C-X-C motif chemokine ligand 8	Homo sapiens	246-250
33937285-5	2021	Among such class of drugs, azithromycin is described as azalide and is well-known for its ability to decrease the production of pro-inflammatory cytokines, including matrix metalloproteinases, tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8.	azalide	56-63	C-X-C motif chemokine ligand 8	Homo sapiens	246-250
32865318-12	2021	Isorhamnetin significantly decreased the expression of interleukin (IL)-1beta, IL-6, IL-8, and C-X-C motif chemokine ligand 10 in BEAS-2B cells induced by TNF-alpha.	3-methylquercetin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
33921194-4	2021	In vitro decitabine administration increased bacterial phagocytosis and IL-8 release, but impaired microbicidal activity of monocytes.	Decitabine	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
33846374-9	2021	DEHP exposure led to a proinflammatory state in SGBS-derived adipocytes (e.g., increased secretion of IL8 and MCP1).	Diethylhexyl Phthalate	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
33508282-9	2021	However, a prolonged exposure with each of the antihistamines impaires the increase in COX-2 and IL-8 mRNA levels induced by histamine, even after ligand removal.	Histamine	51-60	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
33481051-6	2021	A significant release of IL-8 was found after 72 h of exposure to 2.5 mug/cm2 BCDPs.	bcdps	78-83	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
33210765-13	2021	LTA-stimulated DPSCs released IL-6 and IL-8 in a dose-dependent manner (P <= 0.0001).	lipoteichoic acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
33021119-0	2021	Pyrvinium pamoate induces in-vitro suppression of IL-6 and IL-8 produced by human endometriotic stromal cells.	pyrvinium	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
33021119-7	2021	Our Findings showed that pyrvinium pamoate suppresses the mRNA gene expression and secretion of IL-6 and IL-8 in human endometriotic stromal cells.	pyrvinium	25-42	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
33834669-9	2021	Sitagliptin suppressed 5 microg mL-1 of LPS-induced IL-6, IL-8, CCL2, and SOD2 gene expression levels in HGF in a concentration-dependent manner.	Sitagliptin Phosphate	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
33834669-10	2021	Furthermore, sitagliptin significantly decreased the elevated secretion of IL-6, IL-8, and CCL2 protein induced by LPS.	Sitagliptin Phosphate	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
33834669-12	2021	Results of qRT-PCR analysis indicated that 0.5 micromol L-1 of sitagliptin and 5 micromol L-1 of BAY11-7082 significantly inhibited LPS-induced IL-6, IL-8, CCL2, and SOD2 gene expressions.	Sitagliptin Phosphate	63-74	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
33834669-12	2021	Results of qRT-PCR analysis indicated that 0.5 micromol L-1 of sitagliptin and 5 micromol L-1 of BAY11-7082 significantly inhibited LPS-induced IL-6, IL-8, CCL2, and SOD2 gene expressions.	3-(4-methylphenylsulfonyl)-2-propenenitrile	97-107	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
33393728-3	2021	The present study was designed to characterize the mechanisms by which mangiferin protects against NaF-induced neurotoxicity.	mangiferin	71-81	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
33830910-10	2021	Interleukin-8 secretion was induced in TLR4/MD2/CD14-transfected, but not in TLR2-transfected, HEK 293 T cells following TcdB or CDT exposure.Conclusion.	trimethylaminocarboxyldihydroboran	121-125	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
33830910-10	2021	Interleukin-8 secretion was induced in TLR4/MD2/CD14-transfected, but not in TLR2-transfected, HEK 293 T cells following TcdB or CDT exposure.Conclusion.	1,5,9-cyclododecatriene	129-132	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
33582555-3	2021	C/EBPbeta is a leucine-zipper transcription factor that regulates expression of a variety of inflammatory cytokines or chemokines, such as IL-8, G-CSF (granulocyte colony stimulating factor), and GM-CSF (granulocyte macrophage colony stimulating factor) which induce neutrophil infiltration and differentiation.	Leucine	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
33207020-6	2021	For soft tissues, agarose gels with varying concentrations of agarose, gadolinium (Gd) and sodium fluoride (NaF) were developed.	Sepharose	18-25	C-X-C motif chemokine ligand 8	Homo sapiens	108-111
32559758-7	2021	RESULTS: IL-6 and IL-8 were highly expressed in pediatric Q-CPs, and the transcription level of IL-6 was the highest in the severe group.	q-cps	58-63	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
33116000-1	2021	The aim of this study was to investigate the effects of potassium fluoride (KF) and sodium fluoride (NaF) in different concentrations on micro-shear bond strength (microSBS) and their protective effects against acid.	Sodium Fluoride	84-99	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
33859989-8	2021	Furthermore, the serum and urine Zn concentrations negatively correlated with the serum IL-6 and IL-8 concentrations.	Zinc	33-35	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
33346953-7	2021	PAR1 activation also enhanced polyinosinic:polycytodylic acid induction of IL-8 in a human endothelial cell line.	polycytodylic acid	43-61	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
33306627-1	2021	OBJECTIVES: F-sodium fluoride (NaF) is a radiotracer used in PET that reflects calcium metabolism and osteoblastic activity.	f-sodium fluoride	12-29	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
33306627-1	2021	OBJECTIVES: F-sodium fluoride (NaF) is a radiotracer used in PET that reflects calcium metabolism and osteoblastic activity.	Calcium	79-86	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
33849824-7	2021	Amentoflavone down-regulated the mRNA expressions of IL-6 and TNF-alpha, up-regulated mRNA expressions of IL-8 and TGF-beta mRNA (P < 0.05), and increased the protein expressions of PPAR-alpha/gamma, Arg-1 and Fizz1.	amentoflavone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
33841413-7	2021	The TLR4 signaling inhibitor, TAK-242, inhibited HUVEC IL-8 secretion in response to SS plasma by 85%.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	30-37	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
33753826-8	2021	In addition, puerarin reduced the activities of aspartate aminotransferase and alkaline phosphatase, the ratio of serum aspartate aminotransferase to serum alanine aminotransferase, the number of white blood cells and neutrophils, and the plasma concentrations of interleukin-6, interleukin-8 and tumor necrosis factor-alpha, as well as protein abundances of heat shock protein-70 in PEDV-infected piglets.	puerarin	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	279-292
33782320-8	2021	Inflammatory cytokines such as IL-1alpha, IL-8, and tumor necrosis factor-alpha were suppressed by selenium in cultured orbital fibroblasts of patients with GO.	Selenium	99-107	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
33730343-12	2021	The manuscript provides evidence that the phototherapy can interfere with MAPK signaling via cAMP in order to attenuate the IL-8 secretion from CSE-stimulated BEAS.	Cyclic AMP	93-97	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
33524139-7	2021	Following DAAs therapy, the levels of ROS, IL-1beta, IL-6, IL-8 and TNF-alpha were significantly decreased in the three HCV groups.	daas	10-14	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
33738852-3	2021	The objective of the present study was to investigate the protective effects of glycine on sodium fluoride (NaF) exposure and the possible underlying mechanisms in a porcine testicular Sertoli cell line model.	Glycine	80-87	C-X-C motif chemokine ligand 8	Homo sapiens	108-111
33738852-3	2021	The objective of the present study was to investigate the protective effects of glycine on sodium fluoride (NaF) exposure and the possible underlying mechanisms in a porcine testicular Sertoli cell line model.	Sodium Fluoride	91-106	C-X-C motif chemokine ligand 8	Homo sapiens	108-111
33738852-4	2021	Cellular viability and proliferation were examined following NaF exposure and glycine supplementation, and glycine dramatically ameliorated the decreases in NaF-induced porcine testicular Sertoli cell viability and proliferation.	Glycine	107-114	C-X-C motif chemokine ligand 8	Homo sapiens	157-160
33738852-5	2021	Further investigations revealed that glycine decreased NaF-induced intracellular reactive oxygen species production, DNA fragment accumulation, and the apoptosis incidence in the porcine testicular Sertoli cell line; in addition, glycine improved mitochondrial function and ATP production.	Glycine	37-44	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
33738852-5	2021	Further investigations revealed that glycine decreased NaF-induced intracellular reactive oxygen species production, DNA fragment accumulation, and the apoptosis incidence in the porcine testicular Sertoli cell line; in addition, glycine improved mitochondrial function and ATP production.	Oxygen	90-96	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
33738852-5	2021	Further investigations revealed that glycine decreased NaF-induced intracellular reactive oxygen species production, DNA fragment accumulation, and the apoptosis incidence in the porcine testicular Sertoli cell line; in addition, glycine improved mitochondrial function and ATP production.	Glycine	230-237	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
33738852-5	2021	Further investigations revealed that glycine decreased NaF-induced intracellular reactive oxygen species production, DNA fragment accumulation, and the apoptosis incidence in the porcine testicular Sertoli cell line; in addition, glycine improved mitochondrial function and ATP production.	Adenosine Triphosphate	274-277	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
33738852-6	2021	Notably, results of the SPiDER-beta-Gal analysis suggested that glycine alleviated NaF-induced cellular senescence and downregulated P53, P21, HMGA2, and P16INK4a gene expression in the porcine testicular Sertoli cell line.	Glycine	64-71	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
33738852-7	2021	Collectively, the beneficial effects of glycine alleviate NaF-induced oxidative stress, apoptosis and senescence, and together with our previous findings, support the hypothesis that glycine plays an important role in protecting against NaF exposure-induced impairments in the porcine testicular Sertoli cell line.	Glycine	40-47	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
33738852-7	2021	Collectively, the beneficial effects of glycine alleviate NaF-induced oxidative stress, apoptosis and senescence, and together with our previous findings, support the hypothesis that glycine plays an important role in protecting against NaF exposure-induced impairments in the porcine testicular Sertoli cell line.	Glycine	183-190	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
33738852-7	2021	Collectively, the beneficial effects of glycine alleviate NaF-induced oxidative stress, apoptosis and senescence, and together with our previous findings, support the hypothesis that glycine plays an important role in protecting against NaF exposure-induced impairments in the porcine testicular Sertoli cell line.	Glycine	183-190	C-X-C motif chemokine ligand 8	Homo sapiens	237-240
33730343-15	2021	The dexamethasone corticoid produces a significant inhibitory effect on IL-8 as well as ROS secretion, but on the other hand, the corticoid blocked the IL-10 secretion.	Dexamethasone	4-17	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
32789453-1	2021	OBJECTIVE: Sodium fluoride (NaF) has been applied to inhibit glycolysis in venous specimens for decades.	Sodium Fluoride	11-26	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
33189376-7	2021	Likewise, serum Cu was positively associated with HO-1 (beta = 0.0004, P = 0.03) and negatively associated with MCP-1 (beta = -0.0006, P = 0.003) and IL-8 (beta = -0.002, P = 0.03).	Copper	16-18	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
33790807-6	2021	Induction of IL-6, IL-8, and ICAM-1 synthesis from cultured PTECs incubated with IgA-HMC conditioned medium was significantly suppressed by treatment with the Syk inhibitor R406 compared to that from healthy control.	R406	173-177	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
33723220-3	2021	Whether IL-8 predicts depression response to ketamine and in a sex-specific manner is not known.	Ketamine	45-53	C-X-C motif chemokine ligand 8	Homo sapiens	8-12
33710470-8	2021	CONCLUSION: Peripheral blood IL-6 and IL-8 levels could play a role in the severity of DME and UME, respectively.	dme	87-90	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
33842407-0	2021	Ascorbic Acid Suppresses House Dust Mite-Induced Expression of Interleukin-8 in Human Respiratory Epithelial Cells.	Ascorbic Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
33842407-6	2021	The present study was aimed to investigate whether HDM could induce IL-8 expression through activation of MAPKs, NF-kappaB, and AP-1 and whether ascorbic acid could inhibit HDM-stimulated IL-8 expression by reducing ROS and suppressing activation of MAPKs, NF-kappaB, and AP-1 in respiratory epithelial H292 cells.	Ascorbic Acid	145-158	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
33723220-6	2021	Baseline levels of IL-8 had a trending association with response to ketamine, depending upon sex (responder status x sex interaction: p = 0.096), in which lower baseline levels of IL-8 in females (p = 0.095) but not males (p = 0.96) trended with treatment response.	Ketamine	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
33723220-6	2021	Baseline levels of IL-8 had a trending association with response to ketamine, depending upon sex (responder status x sex interaction: p = 0.096), in which lower baseline levels of IL-8 in females (p = 0.095) but not males (p = 0.96) trended with treatment response.	Ketamine	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
33723275-11	2021	In particular, gossypol suppressed the expression of genes coding for CLAUDIN1, ELK1, FAS, GAPDH, IL2, IL8 and ZFAND5 mRNAs, but enhanced the expression of the gene coding for GLUT3 mRNA.	Gossypol	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
33201565-12	2021	Cell experiments showed that overexpression of miR-221-5p significantly inhibited the expression of inflammatory factors tumor necrosis factor-alpha, IL-8, and IL-1beta, while down-regulation of miR-221-5p was the opposite.	-221-5p	50-57	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
33567990-7	2022	Medroxyprogesterone acetate (MPA)/progesterone (P4) and IL-1beta/IL-8 treatment resulted in altered TFV-DP levels in VK2 and PM1 cells.	Dipyridamole	104-106	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
33567990-8	2022	MPA and P4 at concentrations above 0.1 microM, as well as IL-1beta and IL-8 at concentrations above 10 ng/mL significantly decreased HIV-1BaL inhibition in PM1 cells when 1 microM TFV was added.	Tenofovir	180-183	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
33555876-4	2021	Tests for reactive oxygen species (ROS), biomarker expressions (CYP1A1, IL8, COX-2), and mutagenicity (Ames) show that RNG exhaust has toxicity that is comparable or lower than CNG exhaust.	Benzene	119-122	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
33155332-9	2021	Moreover, L-lactic acid level was positively associated with serum CXCL8 level.	Lactic Acid	10-23	C-X-C motif chemokine ligand 8	Homo sapiens	67-72
33483132-13	2021	In healthy volunteers, phenylephrine enhanced the LPS-induced IL-10 response (+76%, P=0.0008) while attenuating plasma concentrations of pro-inflammatory mediators including IL-8 (-15%, P=0.03).	Phenylephrine	23-36	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
33646017-1	2021	Background: Patients with osteoblastic bone metastases are candidates for radium-223 (223RaCl2) therapy and may undergo sodium fluoride-18 (18F-NaF) positron emission tomography-computed tomography imaging to identify bone lesions.	Sodium Fluoride	120-135	C-X-C motif chemokine ligand 8	Homo sapiens	144-147
33646017-2	2021	18F-NaF has been shown to predict 223RaCl2 uptake, but intratumor distributions of these two agents remain unclear.	223racl2	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
33570794-7	2021	Moreover, PARP-1 silencing and PARP inhibitor olaparib can suppress UVB-induced COX-2 and MMP-1 expression, but enhance TNF-alpha and IL-8 expression.	olaparib	46-54	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
33570794-8	2021	In addition, EGFR silencing or EGFR inhibition by gefitinib can decrease UVB-induced COX-2, TNF-alpha, and IL-8 expression, suggesting EGFR activation via paracrine action can mediate UVB-induced inflammation responses.	Gefitinib	50-59	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
33755043-7	2021	SNPs in the CXCL8 gene encoding IL-8 was significantly associated with protection from SICs (chr4: rs1126647, odds ratio [OR] = 0.3, P = 0.005, rs2227543, OR = 0.4, P = 0.007, and rs2227307, OR = 0.4, P = 0.02) after adjusting for age, sex, steroids prediagnosis, and herpes simplex keratitis (HSK) misdiagnosis.	Steroids	241-249	C-X-C motif chemokine ligand 8	Homo sapiens	12-17
33755043-7	2021	SNPs in the CXCL8 gene encoding IL-8 was significantly associated with protection from SICs (chr4: rs1126647, odds ratio [OR] = 0.3, P = 0.005, rs2227543, OR = 0.4, P = 0.007, and rs2227307, OR = 0.4, P = 0.02) after adjusting for age, sex, steroids prediagnosis, and herpes simplex keratitis (HSK) misdiagnosis.	Steroids	241-249	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
33854720-8	2021	Compared with those in the Ctrl, only ARISTIN showed a significant reduction in IL-8 level, whereas TIMP1 levels were significantly upregulated in the Lyc gel and ARISTIN sites.	aristin	38-45	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
33249645-10	2021	Furthermore, significantly higher expression of the pro-inflammatory cytokines IL-6 and IL-8 is detected after FLS cells interacted with NETs which derived from neutrophils stimulated with ACPA-containing IgG antibodies.	arachidonylcyclopropylamide	189-193	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
33404125-2	2021	Tumor necrosis factor (TNF)-alpha/interleukin (IL)-23/IL-17 inflammatory pathway may be involved in the pathogenesis of PPP, and the skin lesions manifest the enhanced expression of IL-8 in keratinocytes and increased levels of antimicrobial peptide cathelicidin, leucine leucine-37 in vesicles/pustules.	Leucine	264-271	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
33039404-10	2021	Gene reporter assays and ChIP-PCR demonstrated that NFAT response element in its promoter played a key role in BA-induced human IL-8 expression.	Bile Acids and Salts	111-113	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
33227158-1	2021	Historically, blood alcohol concentration (BAC) studies utilized a 1% concentration of the preservative sodium fluoride (NaF), leaving an information gap supporting usage of lower concentrations of NaF to preserve ethanol.	Sodium Fluoride	104-119	C-X-C motif chemokine ligand 8	Homo sapiens	121-124
33653802-13	2021	BCG-induced cytokines showed a progressive increase in IL-8 (p=0.02) and TNF-alpha (p=0.04) over time for patients on rapamycin 2.0 mg, whereas patients receiving placebo had no significant change in urinary cytokines.	Sirolimus	118-127	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
33142344-8	2021	Furthermore P. pubescens extract and vouacapan diterpene furan isomer"s mixture significantly decreased IL-8 levels.	vouacapan diterpene furan	37-62	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
33544929-7	2021	The 18Co-CM-induced increase in CD133+CD44+ cells was attenuated by IL-6- and IL-8-neutralizing antibodies.	18co	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
30664079-9	2021	One month after intravitreal steroid injection, the IL-8 levels normalized to 13.28 pg/mL.	Steroids	29-36	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
33671042-8	2021	Butyrate (0.1 mM), propionate (0.3 mM), and TSA inhibited the IL-8 production and activation of NF-kappaB.	Butyrates	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
33671042-2	2021	The aim of this study was to investigate whether intracellular IL-33 mediates the effects of butyrate and propionate on TNFalpha-induced IL-8 production and vascular cell adhesion molecule-1 (VCAM-1) expression.	Butyrates	93-101	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
33707464-8	2021	PGD2 induced IL-8 production by human group 2 innate lymphoid cells, suggesting that PGD2-producing MCs induce neutrophil recruitment into the synovium of RA patients.	Prostaglandin D2	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
33707464-8	2021	PGD2 induced IL-8 production by human group 2 innate lymphoid cells, suggesting that PGD2-producing MCs induce neutrophil recruitment into the synovium of RA patients.	Prostaglandin D2	85-89	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
33639877-13	2021	Eyes with FUS had significantly higher aqueous humor (AH) cytokine levels (VEGF, bFGF, IL-6, IL-8 and IL-10) compared with the control eyes (P < 0.05).	fusarubin	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
33652978-8	2021	RESV cooperated with PRI-2191 in regulating the expression of IL-8 in EGFRmut cells, while OPN in KRASmut cells and PD-L1 in both cell subtypes.	1 alpha,24-dihydroxyvitamin D3	21-29	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
33671042-2	2021	The aim of this study was to investigate whether intracellular IL-33 mediates the effects of butyrate and propionate on TNFalpha-induced IL-8 production and vascular cell adhesion molecule-1 (VCAM-1) expression.	Propionates	106-116	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
33671042-8	2021	Butyrate (0.1 mM), propionate (0.3 mM), and TSA inhibited the IL-8 production and activation of NF-kappaB.	Propionates	19-29	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
33671042-11	2021	In conclusion, we showed that the inhibitory effects of butyrate and propionate on TNFalpha-induced IL-8 production were mediated by the HDACs/IL-33/NF-kappaB pathway, while their effects on VCAM-1 expression might be associated with the HDACs/MAPK signaling pathway, independently of IL-33.	Butyrates	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
33671042-8	2021	Butyrate (0.1 mM), propionate (0.3 mM), and TSA inhibited the IL-8 production and activation of NF-kappaB.	trichostatin A	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
33671042-11	2021	In conclusion, we showed that the inhibitory effects of butyrate and propionate on TNFalpha-induced IL-8 production were mediated by the HDACs/IL-33/NF-kappaB pathway, while their effects on VCAM-1 expression might be associated with the HDACs/MAPK signaling pathway, independently of IL-33.	Propionates	69-79	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
33539102-2	2021	Superoxide anion species (O2-) are detected on the Pt(111) surface in an O2-saturated solution with a NaF/HClO4 mixture with pH 5.5 by the observation of a O-O vibration band at ca.	superoxide anion species	0-24	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
33732225-7	2021	After infection of AGS cells, H. pylori DeltadppA induced a higher level of NF-kappaB activation and IL-8 production compared with wild-type.	deltadppa	40-49	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
33600064-8	2021	The study demonstrated the ultrasound-triggered release of sodium fluorescein (NaF), bovine serum albumin (BSA), and bone morphogenetic protein 2 (BMP-2) from the hydrogels.	Fluorescein	59-77	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
33708766-7	2020	Furthermore, rCdtC reduces H. pylori CagA translocation, which decreases nuclear factor kappa-B activation and interleukin-8 production, resulting in the mitigation of gastric epithelial cell inflammation.	rcdtc	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	111-124
33622325-8	2021	Olodaterol reduced RSV-mediated IL-8 secretion in both COPD and control ALIs and also significantly reduced Muc5AC staining in COPD-ALIs infected with RSV.	olodaterol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
33622325-10	2021	Gene silencing of the beta2-adrenergic receptor in NCI-H292 negated the ability of olodaterol to inhibit IL-8 secretion from both RSV infection and lipopolysaccharide stimulus, as did blocking of the receptor with ICI 118,551 and butaxamine.	olodaterol	83-93	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
33609028-11	2021	The synthetic LXR agonist GW3965 led to a decreased nuclear positivity of the p65 subunit of nuclear factor kappa B, a phosphorylation ratio of the p44-42 MAP kinase, and the expression of CCL-28 and IL-8 in IL-1beta-stimulated Caco-2 cells.	GW 3965	26-32	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
33539102-2	2021	Superoxide anion species (O2-) are detected on the Pt(111) surface in an O2-saturated solution with a NaF/HClO4 mixture with pH 5.5 by the observation of a O-O vibration band at ca.	Oxygen	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
33539102-2	2021	Superoxide anion species (O2-) are detected on the Pt(111) surface in an O2-saturated solution with a NaF/HClO4 mixture with pH 5.5 by the observation of a O-O vibration band at ca.	Platinum	51-53	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
33539102-2	2021	Superoxide anion species (O2-) are detected on the Pt(111) surface in an O2-saturated solution with a NaF/HClO4 mixture with pH 5.5 by the observation of a O-O vibration band at ca.	Oxygen	26-28	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
33359650-5	2021	We demonstrate the ICS fluticasone propionate (FP) and two selective non-steroidal (GRT7) and steroidal (GRT10) glucocorticoid receptor (GR) agonists significantly suppress pro-inflammatory (IL-6 and IL-8) and antiviral (IFN-lambda1) cytokine production and the expression of the interferon-stimulated genes (ISGs) OAS and viperin in RV-infected bronchial epithelial cells, with a consequent increase of viral replication.	Fluticasone	23-45	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
33597583-6	2021	Non-DAUs- (n = 15) showed improved brachial flow-mediated dilation (FMD) and reduced circulating IL-8, IL-12, and leptin.	daus	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
33578781-5	2021	Moreover, the stimulatory effects of H2O2 on cellular senescence are associated with oxidative stress induction, such as excessive ROS production and NADPH consumption, telomere DNA damage induction, and upregulation of senescence-associated secretory phenotype factors (IL-1beta, IL-6, IL-8, COX-2, and TNF-alpha) as well as NF-kappaB activation, which were all blocked by FK866.	Hydrogen Peroxide	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	287-291
33581965-10	2021	Also, the AGEs-elicited production of IL-6 and IL-8 was inhibited by Magnolol.	magnolol	69-77	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
33643049-9	2021	mRNA expression of CXCL8, CYR61, FGF16 and FGFRL1 was significantly elevated by the Rb2/Rg3 treatment, and representative signaling pathways induced by these genes were found.	ginsenoside Rg3	88-91	C-X-C motif chemokine ligand 8	Homo sapiens	19-24
33643049-11	2021	The present study provides the hypothesis that SBP, via ginsenosides Rb2 and Rg3, involves the CXCR1/2 CXCL8 (IL8)-mediated PI3K/Akt and MAPK/ERK signaling pathways in achieving its proangiogenic effects.	ginsenoside Rg3	77-80	C-X-C motif chemokine ligand 8	Homo sapiens	103-108
33643049-11	2021	The present study provides the hypothesis that SBP, via ginsenosides Rb2 and Rg3, involves the CXCR1/2 CXCL8 (IL8)-mediated PI3K/Akt and MAPK/ERK signaling pathways in achieving its proangiogenic effects.	ginsenoside Rg3	77-80	C-X-C motif chemokine ligand 8	Homo sapiens	110-113
33559204-5	2021	The results showed that SiO2 stimulated the production of reactive oxygen species and malondialdehyde in the supernatant of THP-1-derived macrophages and increased the secretion of TGF-beta1, TNF-alpha, and IL-8.	Silicon Dioxide	24-28	C-X-C motif chemokine ligand 8	Homo sapiens	207-211
33644593-6	2021	In addition, feprazone prevented FFA-induced expression and secretion of proinflammatory cytokines and chemokines, such as chemokine ligand 5 (CCL5), interleukin-6 (IL-6), and interleukin-8 (IL-8).	Feprazone	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	176-189
33644593-6	2021	In addition, feprazone prevented FFA-induced expression and secretion of proinflammatory cytokines and chemokines, such as chemokine ligand 5 (CCL5), interleukin-6 (IL-6), and interleukin-8 (IL-8).	Feprazone	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
33562298-7	2021	However, co-treatment with TUDCA alleviated inflammatory response induced by IL-1beta, as shown by down regulation of Il-1beta, Il-6, Il-8 and Cox2, and increased the expression of antioxidant enzyme Sod2.	ursodoxicoltaurine	27-32	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
33567596-6	2021	Our results showed that (i) caffeic acid targets COX-2 and its product PGE2 as well as the biosynthesis of IL-8 in the IL-1beta-treated cells and (ii) inhibits AGE formation, which could be related to (iii) the high chelating activity exerted.	caffeic acid	28-40	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
33302150-5	2021	To immobilise well-controlled soluble gradients of interleukin-8 (CXCL8), an inflammatory chemokine, we developed a simple procedure using a heparin-coated PDMS-microfluidic device.	Heparin	141-148	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
33539038-12	2021	According to the cytokine antibody array results, hOBs pretreated with AZA had significantly increased production of several inflammatory cytokines (P<0.05), in which the expression levels of IL-6 and IL-8 were the most dramatically increased upon LTA stimulation (P<0.01).	hobs	50-54	C-X-C motif chemokine ligand 8	Homo sapiens	201-205
33539038-12	2021	According to the cytokine antibody array results, hOBs pretreated with AZA had significantly increased production of several inflammatory cytokines (P<0.05), in which the expression levels of IL-6 and IL-8 were the most dramatically increased upon LTA stimulation (P<0.01).	Decitabine	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	201-205
33539038-12	2021	According to the cytokine antibody array results, hOBs pretreated with AZA had significantly increased production of several inflammatory cytokines (P<0.05), in which the expression levels of IL-6 and IL-8 were the most dramatically increased upon LTA stimulation (P<0.01).	lipoteichoic acid	248-251	C-X-C motif chemokine ligand 8	Homo sapiens	201-205
33557291-9	2021	Solely in the open surgery group, cortisol dynamics paralleled changes in interleukin (IL)-1beta, IL-10, IL-1ra, IL-7, IL-8 and tumor necrosis factor (TNF)-alpha but did not correlate with changes in IL-6 or interferon (IFN)-gamma at any time-point.	Hydrocortisone	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
33302150-5	2021	To immobilise well-controlled soluble gradients of interleukin-8 (CXCL8), an inflammatory chemokine, we developed a simple procedure using a heparin-coated PDMS-microfluidic device.	Heparin	141-148	C-X-C motif chemokine ligand 8	Homo sapiens	66-71
33352397-0	2021	IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1alpha pathway in human IL-8-expressing mice.	Alcohols	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
33022353-6	2021	Overexpression of duIKKalpha dramatically increased NF-kappaB activity and induced the expression of duck cytokines IFN-beta, IL-1beta, IL-6, IL-8 and RANTES in DEFs.	duikkalpha	18-28	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
33352397-0	2021	IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1alpha pathway in human IL-8-expressing mice.	Alcohols	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
33352397-6	2021	We found that hIL-8 can exacerbate alcohol-induced fatty liver disease via the Akt/HIF-1alpha pathway.	Alcohols	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	14-19
33352397-8	2021	Moreover, hIL-8 could increase the alcohol-induced release of ROS in fatty liver caused by alcohol and exacerbate fatty liver disease.	Alcohols	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	10-15
33352397-8	2021	Moreover, hIL-8 could increase the alcohol-induced release of ROS in fatty liver caused by alcohol and exacerbate fatty liver disease.	Alcohols	91-98	C-X-C motif chemokine ligand 8	Homo sapiens	10-15
33175611-11	2021	Among the inflammatory factors examined (IL-6, IL-8, IL-10, and TNF-alpha), we found that IL-8 was significantly increased after treatment with 3OC12HSL and its expression was inhibited when TLR2 was specifically blocked or silenced.	N-(3-oxododecanoyl)homoserine lactone	144-152	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
33175611-11	2021	Among the inflammatory factors examined (IL-6, IL-8, IL-10, and TNF-alpha), we found that IL-8 was significantly increased after treatment with 3OC12HSL and its expression was inhibited when TLR2 was specifically blocked or silenced.	N-(3-oxododecanoyl)homoserine lactone	144-152	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
33336605-10	2021	A final concentration of 9 microg/mL of azithromycin was sufficient to decrease IL-6, IL-8 mRNA, and extracellular IL-8 levels.	Azithromycin	40-52	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
32725797-0	2021	Azithromycin and ciprofloxacin inhibit interleukin-8 secretion without disrupting human sinonasal epithelial integrity in vitro.	Azithromycin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
33336605-10	2021	A final concentration of 9 microg/mL of azithromycin was sufficient to decrease IL-6, IL-8 mRNA, and extracellular IL-8 levels.	Azithromycin	40-52	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
33336605-11	2021	Conclusion: Pretreatment with azithromycin decreased the expression of IL-6 and IL-8 mRNA and the release of IL-8 in bronchial epithelial cells exposed to cigarette smoke.	Azithromycin	30-42	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
33336605-11	2021	Conclusion: Pretreatment with azithromycin decreased the expression of IL-6 and IL-8 mRNA and the release of IL-8 in bronchial epithelial cells exposed to cigarette smoke.	Azithromycin	30-42	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
33417258-7	2021	Our data provide the first complete transcriptome for aldosterone on a human renal cell line and identifies pro-inflammatory markers (IL6, IL11, CCL7, and CXCL8) as aldosterone-repressed genes.	Aldosterone	165-176	C-X-C motif chemokine ligand 8	Homo sapiens	155-160
32725797-0	2021	Azithromycin and ciprofloxacin inhibit interleukin-8 secretion without disrupting human sinonasal epithelial integrity in vitro.	Ciprofloxacin	17-30	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
33499425-4	2021	The aim of the study was to verify the possibility of using [18F]F-sodium fluoride ([18F]F-NaF) and [18F]F-fluorodeoxyglucose ([18F]F-FDG) positron emission tomography/computed tomography (PET/CT) in assessing the intensity of TAVI valve degenerative processes.	f-sodium fluoride	65-82	C-X-C motif chemokine ligand 8	Homo sapiens	91-94
33300083-12	2021	The levels of interleukin-8, matrix metalloproteinase 9 and C-reactive protein were increased in the conditioned media (CM) of rGal-10-treated gingival fibroblasts.	rgal-10	127-134	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
33251898-7	2021	RESULTS: Etidronate down-regulated IL-8 and MCP-1 production and NF-kappaB p65 activation induced by Pam3CSK4, but not lipid A, in U937 cells.	Etidronic Acid	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
33524223-11	2021	Furthermore, ELISA experiments revealed that the SASP-CM of Dox treated cells contain inflammatory cytokines IL8 and IP10.	Doxorubicin	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	109-112
33575345-4	2021	Sudachitin inhibited IL-1beta-induced IL-6, IL-8, CXC chemokine ligand (CXCL)10, CC chemokine ligand (CCL)2, MMP-1, and MMP-3 production in HPDLC.	sudachitin	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
33474695-2	2021	We describe aortic microcalcification activity (AMA), a novel method for quantifying 18F-sodium fluoride (18F-NaF) uptake in the thoracic aorta.	18f-sodium fluoride	85-104	C-X-C motif chemokine ligand 8	Homo sapiens	110-113
33498195-8	2021	Indeed, it was observed that both FM and DFM decreased the IL-6, IL-8, and nitric oxide (NO) release similarly to the reference anti-inflammatory drug dexamethasone.	N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
33396024-0	2021	HER2 overexpression triggers the IL-8 to promote arsenic-induced EMT and stem cell-like phenotypes in human bladder epithelial cells.	Arsenic	49-56	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
33396024-6	2021	Phosphorylation of the human epidermal growth factor receptor 2 (HER2) was key for arsenic-induced IL-8 overexpression and depended on the simultaneous activation of the MAPK, JNK, PI3K/AKT and GSK3beta signaling pathways.	Arsenic	83-90	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
33396024-8	2021	These results demonstrate that the HER2/IL-8 axis is related to the acquisition of an EMT phenotype and CSCs in arsenic-treated cells.	Arsenic	112-119	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
32390406-13	2021	Furthermore, astragalin reduced the level of phosphorylated IkappaBalpha and decreased the production of the inflammatory cytokines IL-6, IL-8, and TNF-alpha in the DSS-treated colon mucosa.	astragalin	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
33396129-4	2021	Treatment with NPs-Nd2O3 induced an inflammatory response in human bronchial epithelial cells (16HBE) by upregulating the expression of interleukin-6 (IL-6) and interleukin-8 (IL-8).	nps-nd2o3	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	161-174
33396129-4	2021	Treatment with NPs-Nd2O3 induced an inflammatory response in human bronchial epithelial cells (16HBE) by upregulating the expression of interleukin-6 (IL-6) and interleukin-8 (IL-8).	nps-nd2o3	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
33396131-6	2021	This study aimed to determine the effect of sodium fluoride (NaF) on human RBC under in vitro conditions.	Sodium Fluoride	44-59	C-X-C motif chemokine ligand 8	Homo sapiens	61-64
33396131-8	2021	Treatment of RBC with NaF enhanced the generation of reactive oxygen and nitrogen species.	Nitrogen	73-81	C-X-C motif chemokine ligand 8	Homo sapiens	22-25
33396131-10	2021	NaF treatment increased the degradation of heme causing release of free iron from its porphyrin ring.	Heme	43-47	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
33396131-10	2021	NaF treatment increased the degradation of heme causing release of free iron from its porphyrin ring.	Iron	72-76	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
33396131-11	2021	Cellular antioxidant power was significantly decreased in NaF-treated RBC, lowering the metal reducing and free radical quenching ability of cells.	Metals	88-93	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
32390406-13	2021	Furthermore, astragalin reduced the level of phosphorylated IkappaBalpha and decreased the production of the inflammatory cytokines IL-6, IL-8, and TNF-alpha in the DSS-treated colon mucosa.	Dextran Sulfate	165-168	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
33746631-1	2021	18F-sodium fluoride (18F-NaF) positron emission tomography (PET) has emerged as a promising noninvasive imaging tool for the assessment of active calcification processes in coronary artery disease.	18f-sodium fluoride	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
33431859-6	2021	As proof-of-principle, we show that inhibition of CXCL8 receptor by the small-molecule non-competitive inhibitor repertaxin attenuated the progression of UC phenotypes in vitro and in vivo.	reparixin	113-123	C-X-C motif chemokine ligand 8	Homo sapiens	50-55
33505496-2	2021	However, TACE-induced hypoxia may promote the angiogenesis and section of some cytokines, such as IL-8, and, thereby, lead to tumor metastasis.	Chlorotrianisene	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
33505496-5	2021	TACE induced significant increases of neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), IL-1beta, IL-2R, IL-6, and IL-8.	Chlorotrianisene	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
33505496-9	2021	Both hypoxia and IL-8 may promote angiogenesis which was suppressed by JR. Western blot showed that IL-8 upregulated the expression of phosphorylation of AKT, ERK, NF-kappaB, and VEGFR, which were inhibited by JR. On the other hand, effects of IL-8 on the increase of p-AKT and p-ERK were also blocked by LY294002 and U0126, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	305-313	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
33505496-9	2021	Both hypoxia and IL-8 may promote angiogenesis which was suppressed by JR. Western blot showed that IL-8 upregulated the expression of phosphorylation of AKT, ERK, NF-kappaB, and VEGFR, which were inhibited by JR. On the other hand, effects of IL-8 on the increase of p-AKT and p-ERK were also blocked by LY294002 and U0126, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	305-313	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
33505496-9	2021	Both hypoxia and IL-8 may promote angiogenesis which was suppressed by JR. Western blot showed that IL-8 upregulated the expression of phosphorylation of AKT, ERK, NF-kappaB, and VEGFR, which were inhibited by JR. On the other hand, effects of IL-8 on the increase of p-AKT and p-ERK were also blocked by LY294002 and U0126, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	305-313	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
33505496-9	2021	Both hypoxia and IL-8 may promote angiogenesis which was suppressed by JR. Western blot showed that IL-8 upregulated the expression of phosphorylation of AKT, ERK, NF-kappaB, and VEGFR, which were inhibited by JR. On the other hand, effects of IL-8 on the increase of p-AKT and p-ERK were also blocked by LY294002 and U0126, respectively.	U 0126	318-323	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
33505496-9	2021	Both hypoxia and IL-8 may promote angiogenesis which was suppressed by JR. Western blot showed that IL-8 upregulated the expression of phosphorylation of AKT, ERK, NF-kappaB, and VEGFR, which were inhibited by JR. On the other hand, effects of IL-8 on the increase of p-AKT and p-ERK were also blocked by LY294002 and U0126, respectively.	U 0126	318-323	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
33301812-8	2021	Pretreatment of PK 11195 suppressed while AC-5216 potentiated CSM-induced apoptosis, collapse of DeltaPsim, elevation of cytoplasmic/mitochondrial ROS levels and IL-8 release.	N-benzyl-N-ethyl-2-(7,8-dihydro-7-methyl-8-oxo-2-phenyl-9H-purin-9-yl)acetamide	42-49	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
32792028-6	2021	Dietary OxBC supplementation decreased the TNF-alpha and IL-8 levels in colostrum, as well as the TNF-alpha and IL-18 levels in 14-d milk.	dietary oxbc	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
33521454-5	2021	Additionally, roflumilast prevented IL-18-induced expressions and secretions of pro-inflammatory cytokines such as IL-6, IL-8, and TNF-alpha.	Roflumilast	14-25	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
33505496-9	2021	Both hypoxia and IL-8 may promote angiogenesis which was suppressed by JR. Western blot showed that IL-8 upregulated the expression of phosphorylation of AKT, ERK, NF-kappaB, and VEGFR, which were inhibited by JR. On the other hand, effects of IL-8 on the increase of p-AKT and p-ERK were also blocked by LY294002 and U0126, respectively.	U 0126	318-323	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
33420112-5	2021	Proteomics analysis of OCT-treated skin wounds revealed significant lower levels of key players in tissue remodeling as well as reepithelization after wounding such as pro-inflammatory cytokines (IL-8, IL-6) and matrix-metalloproteinases (MMP1, MMP2, MMP3, MMP9) when compared to controls.	octenidine	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
33505216-6	2021	The anti-inflammatory mechanism of GL and GA is realized via cytokines like interferon-gamma, tumor necrotizing factor-alpha, interleukin- (IL-) 1beta, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, and IL-17.	gl	35-37	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
33413425-3	2021	Different concentrations of Dex were used to attenuate the inflammation induced by IL-1beta, and its effect was assessed via RT-PCR to detect inflammatory cytokine-related mRNA levels, including those of IKbeta-alpha, IKKbeta, IL-6, IL-8, and TNF-alpha.	Dexamethasone	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	233-237
33505216-6	2021	The anti-inflammatory mechanism of GL and GA is realized via cytokines like interferon-gamma, tumor necrotizing factor-alpha, interleukin- (IL-) 1beta, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, and IL-17.	Glycyrrhetinic Acid	42-44	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
33055419-7	2021	We identified fluvastatin as an inducer of galectin-7 expression by connectivity map (cMAP) analysis, confirmed this effect in keratinocytes, and demonstrated that fluvastatin attenuated IL-6 and IL-8 production induced by IL-17A.	Fluvastatin	14-25	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
32763720-10	2021	Finally, NaOH and HF solutions were used to prepare high-purity NaF (>98 %) to treat the waste solutions.	Sodium Hydroxide	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
32763720-10	2021	Finally, NaOH and HF solutions were used to prepare high-purity NaF (>98 %) to treat the waste solutions.	Hafnium	18-20	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
33055419-7	2021	We identified fluvastatin as an inducer of galectin-7 expression by connectivity map (cMAP) analysis, confirmed this effect in keratinocytes, and demonstrated that fluvastatin attenuated IL-6 and IL-8 production induced by IL-17A.	Fluvastatin	164-175	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
33389640-6	2021	RESULTS: There was a significant difference between the NaF uptake in the thoracic aorta of myeloma and HC groups [AA (myeloma = 1.82 +- 0.21, HC = 1.24 +- 0.02), AR (myeloma = 1.71 +- 0.19, HC = 1.28 +- 0.03) and DA (myeloma = 1.96 +- 0.28, HC = 1.38 +- 0.03); P-values < 0.001].	amsonic acid	214-216	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
33267660-2	2021	18F-sodium fluoride positron emission tomography (18F-NaF PET) detects early and active calcifications within the vasculature.	18f-sodium fluoride	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
33861459-7	2021	Treatment with MgSO4 results in a significant reduction in serum levels of NGAL, Hb, T.Bill, IL-6, IL-8, SNSE, S100B, EGF, PAF, CRP and IgG.	Magnesium Sulfate	15-20	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
33861459-9	2021	Moreover, reduction of IL-6, IL-8, SNSE, EGF and APACHE score and increase in RASS score were significantly higher in MgSO4 group compared with placebo.	Magnesium Sulfate	118-123	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
33267660-7	2021	We compared the proportion of CCS progressors in 18F-NaF PET-positive versus 18F-NaF PET-negative coronary arteries.	Fluorine-18	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
33267660-11	2021	All subjects (100%, 15/15) with >=2 18F-NaF-positive coronary arteries progressed in CCS.	Fluorine-18	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
33540416-13	2021	In contrast, 1,25 (OH)2 D3 pretreatment increased the production of IL-8 by LPS- and LTA-stimulated endometrial cells.	Calcitriol	13-26	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
33509458-5	2021	Significantly stronger inhibition of TNF-alpha-induced IL-8 production was found in cells pre-treated with different concentrations of mixtures of BtA and the phenolic metabolites than individual compounds.	Butyric Acid	147-150	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
33540416-13	2021	In contrast, 1,25 (OH)2 D3 pretreatment increased the production of IL-8 by LPS- and LTA-stimulated endometrial cells.	lipoteichoic acid	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
33218942-8	2021	The expressions of TLR4/NF-kappaBp65, IL-1beta, IL-6, IL-8, and TNF-alpha significantly increased in the model group while they were down-regulated in the rebamipide pretreatment group (p < 0.05).	rebamipide	155-165	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
33285354-6	2021	The highest levels of IL-1beta, IL-6, CCL2 and IL-8 were observed with MSU at 0.5 mg/ml, CPP at 0.01-0.05 mg/ml and BCP at 1 mg/ml after 18-48 h and then decreased.	Uric Acid	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
33285354-6	2021	The highest levels of IL-1beta, IL-6, CCL2 and IL-8 were observed with MSU at 0.5 mg/ml, CPP at 0.01-0.05 mg/ml and BCP at 1 mg/ml after 18-48 h and then decreased.	bcp	116-119	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
33866338-1	2021	OBJECTIVE: The goal of this study was to test if changes in coronary microcalcification over a two year period assessed by fluorine-18-sodium fluoride (18F-NaF) positron emission tomography/computed tomography (PET/CT) are associated with baseline subject characteristics.	fluorine-18-sodium fluoride	123-150	C-X-C motif chemokine ligand 8	Homo sapiens	156-159
32510596-1	2021	Proteasome inhibitor MG132 was shown to enhance the secretion of interleukin 8 (IL-8) by various cells.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	21-26	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
33390798-13	2021	Release of IL-8 into cell supernatant was increased after stimulation with suture material and was further enhanced if minor amounts of bacterial lipoteichoic acid (LTA) were added.	lipoteichoic acid	146-163	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
33390798-13	2021	Release of IL-8 into cell supernatant was increased after stimulation with suture material and was further enhanced if minor amounts of bacterial lipoteichoic acid (LTA) were added.	lipoteichoic acid	165-168	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
32791248-7	2021	T2 POS was positively associated with eosinophils, IgE, and FeNO, and negatively with AQLQ, sputum neutrophils, IL-17A, IL-8, and TNF-alpha.	t2 pos	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
32510596-4	2021	The purpose of the present study was to explore the combinations of the AP-1 family proteins that contribute to MG132-driven IL-8 secretion.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	112-117	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
32510596-6	2021	IL-8 secretion was augmented by MG132 in both cell lines.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	32-37	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
32510596-12	2021	In contrast to our expectations, MG132-induced IL-8 secretion was significantly reduced in all the transfectants suggesting that other c-Jun members might form homodimers with c-Jun and contribute to IL-8 enhancement.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	33-38	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
33325132-0	2021	Resveratrol treatment reduces expression of MCP-1, IL-6, IL-8 and RANTES in endometriotic stromal cells.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
32510596-12	2021	In contrast to our expectations, MG132-induced IL-8 secretion was significantly reduced in all the transfectants suggesting that other c-Jun members might form homodimers with c-Jun and contribute to IL-8 enhancement.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	33-38	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
33325132-3	2021	In this study, we evaluated the effects of resveratrol treatment on expression of monocyte chemotactic protein-1 (MCP-1), interleukin-6 (IL-6), IL-8, and regulated upon activation, normal T cell expressed and secreted (RANTES) in endometrial stromal cells from patients with endometriosis compared with non-endometriotic controls.	Resveratrol	43-54	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
33131809-11	2021	Expression of TNF and IL1B was upregulated when exposed to LPS (P < 0.001), and expression of CXCL2 and CXCL8 increased following LPS exposure with SCFA (medium x LPS; P < 0.001).	Fatty Acids, Volatile	148-152	C-X-C motif chemokine ligand 8	Homo sapiens	104-109
33325132-5	2021	Resveratrol treatment significantly reduced gene and protein expression of MCP-1, IL-6, and IL-8 in EuESCs and EESCs compared with CESCs (P < .05-.001, P < .05-.001 and P < .05-<.01, respectively), and this reduction was more noticeable in EESCs than EuESCs (P < .05-<.001).	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
33325132-7	2021	Resveratrol treatment significantly reduced the expression of MCP-1, IL-6, IL-8 and RANTES in EESCs.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
33011099-12	2021	Sputum neutrophils, eosinophils, and neutrophil elastase were numerically reduced, and significant (p<0.05) reductions in IL-8 and immunoglobulin G levels occurred with lenabasum.	lenabasum	169-178	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
33188848-1	2021	OBJECTIVES: To examine the enamel fluoride uptake and remineralization potential of arginine-fluoride (Arg-NaF) varnishes in a simulated clinical condition using a multi-species bacterial pH-cycling model.	arginine-fluoride	84-101	C-X-C motif chemokine ligand 8	Homo sapiens	107-110
33188848-13	2021	in a 5% NaF varnish enhanced the enamel fluoride uptake and remineralization potential of the conventional 5% NaF varnish.	Fluorides	40-48	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
33188848-14	2021	CLINICAL SIGNIFICANCE: The Arg-NaF varnish addresses the limitations of fluorides on cariogenic biofilms.	Fluorides	72-81	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
32866050-11	2021	In conclusion, protocol B, which applied a 25% AgNO3 solution followed by a commercially available 5% NaF varnish with fTCP semiannually, is more effective in arresting dentine caries in primary teeth as compared with protocol A, which applied a 25% AgNO3 solution followed by another commercially available 5% NaF varnish without fTCP semiannually (ClinicalTrials.gov NCT03423797).	4-Fluoro-1-(1-(2-thienyl)cyclohexyl)piperidine	119-123	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
33188848-4	2021	Experimental and control groups were: 1% Arg-NaF; 2% Arg-NaF; 4% Arg-NaF; NaF and no treatment.	Arginine	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
33188848-15	2021	The Arg-NaF varnish appears a promising caries-preventive regimen that counters the pathogenic biofilms by Arg and promotes remineralization with fluorides.	Arginine	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
33188848-15	2021	The Arg-NaF varnish appears a promising caries-preventive regimen that counters the pathogenic biofilms by Arg and promotes remineralization with fluorides.	Arginine	107-110	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
33188848-4	2021	Experimental and control groups were: 1% Arg-NaF; 2% Arg-NaF; 4% Arg-NaF; NaF and no treatment.	Arginine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
33188848-15	2021	The Arg-NaF varnish appears a promising caries-preventive regimen that counters the pathogenic biofilms by Arg and promotes remineralization with fluorides.	Fluorides	146-155	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
33188848-4	2021	Experimental and control groups were: 1% Arg-NaF; 2% Arg-NaF; 4% Arg-NaF; NaF and no treatment.	Arginine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
33188848-4	2021	Experimental and control groups were: 1% Arg-NaF; 2% Arg-NaF; 4% Arg-NaF; NaF and no treatment.	Arginine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
33188848-4	2021	Experimental and control groups were: 1% Arg-NaF; 2% Arg-NaF; 4% Arg-NaF; NaF and no treatment.	Arginine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
33188848-8	2021	RESULTS: Increasing concentrations of Arg in NaF varnish significantly increased the EFU of incipient caries-like lesions (p < 0.001).	Arginine	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
33384825-2	2021	The purpose of this study was to evaluate the surface changes of resin-modified glass ionomer (RMGI) when immersed in a sodium fluoride (NaF) solution according to pH and time.	Sodium Fluoride	120-135	C-X-C motif chemokine ligand 8	Homo sapiens	137-140
33140461-4	2021	The Km values of GCP1 toward H2 O2 and guaiacol were lower than GCP2.	Hydrogen Peroxide	29-34	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
33188848-9	2021	The PFU for 1% Arg-NaF was significantly higher than 4% Arg-NaF and the control NaF (p < 0.05).	PBMF protocol	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
33140461-4	2021	The Km values of GCP1 toward H2 O2 and guaiacol were lower than GCP2.	Guaiacol	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
33140461-8	2021	Both peroxidases showed the same thermal stability range 20-50 C. GCP2 was more resistant against the effect of metal ions than GCP1.	Metals	112-117	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
33140461-14	2021	Cationic peroxidase GCP1, as a natural scavenger, had high affinity toward H2 O2 coupled to oxidation of some plant phenolic compounds suggesting its role in consuming of excess H2 O2 .	Hydrogen Peroxide	75-80	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
33384825-5	2021	Results: Rougher topography and increased roughness was exhibited in NaF groups, owing to the disintegration of the polysalt matrix.	polysalt	116-124	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
33384825-6	2021	Reduced Sr and F was exhibited in all groups, whereas NaF group showed a decrease in Al and inorganic components.	Aluminum	85-87	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
33188848-9	2021	The PFU for 1% Arg-NaF was significantly higher than 4% Arg-NaF and the control NaF (p < 0.05).	Arginine	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
33140461-14	2021	Cationic peroxidase GCP1, as a natural scavenger, had high affinity toward H2 O2 coupled to oxidation of some plant phenolic compounds suggesting its role in consuming of excess H2 O2 .	Hydrogen Peroxide	178-183	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
33188848-9	2021	The PFU for 1% Arg-NaF was significantly higher than 4% Arg-NaF and the control NaF (p < 0.05).	Arginine	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
33188848-9	2021	The PFU for 1% Arg-NaF was significantly higher than 4% Arg-NaF and the control NaF (p < 0.05).	Arginine	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
33188848-10	2021	Post pH-cycling, Ca/P ratio with 1%/2% Arg-NaF was closest to hydroxyapatite (1.67).	Phosphorus	0-1	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
32360175-11	2021	The application of SP600125 (10 muM) significantly suppressed the induction of IL-6 and IL-8 by GroEL-treated cells.	pyrazolanthrone	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
33188848-10	2021	Post pH-cycling, Ca/P ratio with 1%/2% Arg-NaF was closest to hydroxyapatite (1.67).	Arginine	39-42	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
33188848-10	2021	Post pH-cycling, Ca/P ratio with 1%/2% Arg-NaF was closest to hydroxyapatite (1.67).	Durapatite	62-76	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
33249629-2	2021	The anti-inflammatory potential of Naringenin-LCNs evaluated by qPCR revealed a decreased expression of IL-6, IL-8, IL-1beta, and TNF-alpha in lipopolysaccharide-induced BCi-NS1.1 cells.	naringenin-lcns	35-50	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
33249629-8	2021	In addition, Naringenin-loaded LCNs efficiently reduced the levels of pro-inflammatory markers, namely, IL-1beta, IL-6, TNF-alpha, and IL-8.	naringenin	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
33188848-11	2021	Mineral gain and % remineralization of 1%/2% Arg-NaF was significantly higher than the control NaF varnish (p < 0.05).	Arginine	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
33283480-8	2021	C-NP nanoparticles also stimulate the release of IL-lbeta, MCP-1, TNF-alpha, IL-8, IL-12p70, IL-17, IL-18, and IL-23 from MDM.	c-np	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
33249629-8	2021	In addition, Naringenin-loaded LCNs efficiently reduced the levels of pro-inflammatory markers, namely, IL-1beta, IL-6, TNF-alpha, and IL-8.	lcns	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
33885393-5	2021	Aim: This study aimed to evaluate the clinical effectiveness of biannual application of 38% SDF followed by 5% sodium fluoride (NaF) varnish for arresting dental caries in children and its parental acceptance.	Sodium Fluoride	111-126	C-X-C motif chemokine ligand 8	Homo sapiens	128-131
33952789-3	2021	Furthermore, fibroblasts exposed to CP-BSA, which is a model of extracellular CPs, had upregulated expression levels of mRNAs encoding matrix metalloproteinase-1 (MMP-1) and interleukin-8/CXCL8 (IL-8/CXCL8).	cps	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	174-193
33952789-3	2021	Furthermore, fibroblasts exposed to CP-BSA, which is a model of extracellular CPs, had upregulated expression levels of mRNAs encoding matrix metalloproteinase-1 (MMP-1) and interleukin-8/CXCL8 (IL-8/CXCL8).	cps	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
33952789-3	2021	Furthermore, fibroblasts exposed to CP-BSA, which is a model of extracellular CPs, had upregulated expression levels of mRNAs encoding matrix metalloproteinase-1 (MMP-1) and interleukin-8/CXCL8 (IL-8/CXCL8).	cps	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	188-193
32294652-11	2021	RESULTS: Combined administration of vinpocetine and dexamethasone lowered the expression levels of serum inflammatory cytokines, including TLR2, TLR4, interleukin (IL)-20, IL-8, tumor necrosis factor-alpha, interferon-gamma, monocyte chemoattractant protein 2, and interferon-induced protein 20, when compared to dexamethasone monotherapy.	vinpocetine	36-47	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
32294652-11	2021	RESULTS: Combined administration of vinpocetine and dexamethasone lowered the expression levels of serum inflammatory cytokines, including TLR2, TLR4, interleukin (IL)-20, IL-8, tumor necrosis factor-alpha, interferon-gamma, monocyte chemoattractant protein 2, and interferon-induced protein 20, when compared to dexamethasone monotherapy.	Dexamethasone	52-65	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
33356884-6	2021	Nicaraven suppressed TNFalpha-induced mRNA expression of multiple adhesion molecules and pro-inflammatory cytokines, including VCAM-1, ICAM-1, E-selectin, MCP-1, TNFalpha, IL-1beta, IL-6 and IL-8.	nicaraven	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
33491385-0	2021	Preventive effect of subacidic 1% NaF-HF gel on dental caries in 6- to 7-year-old schoolchildren: a randomized controlled trial.	Hafnium	38-40	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
33396644-7	2020	In response to LPS stimulation, the gene expression levels of IL-6 and IL-8 in hGFs increased due to AZM in a concentration-dependent manner, and phosphorylation of nuclear factor kappa B (NF-kappaB) was also promoted.	Azithromycin	101-104	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
33396644-10	2020	Thus, AZM may increase the expression of IL-6 and IL-8 under LPS stimulation to modify the inflammatory response and increase the expression of MMP-1 to promote connective tissue remodeling.	Azithromycin	6-9	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
33371832-7	2021	Furthermore, NAC decreases TNF-alpha, IL-1beta, IL-6, IL-8, IL-10, and IL-17 serum levels in patients with sepsis, severe burns, acute liver failure, or peritoneal dialysis and may also reduce cytokine storm in COVID-19.	Acetylcysteine	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
33374148-2	2020	Fluorocholine-18 (FCH) and sodium fluoride-18 (NaF) have been used to assess PCa associated skeletal disease in thousands of patients by demonstrating different mechanism of uptake-cell membrane (lipid) synthesis and bone mineralization.	sodium fluoride-18	27-45	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
33374148-11	2020	Total accelerated osteoblastic (bone demineralization) activity for NaF (TBA varied from 0.25 to 13.6 [kg] in M group and varied from 0.000 to 1.09 [kg] in N group.	tba	73-76	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
33441226-8	2021	Interestingly, while SB203580 inhibited the activation of p38 MAPK signaling pathway, it only inhibited the mRNA levels of IL-6 and IL-8 in HDM-induced 16HBE cells, but had no effect on their protein levels.	SB 203580	21-29	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
33380519-0	2021	18F-Sodium Fluoride (NaF) PET/CT in obese patients on LYSO PET/CT system: Patient dosimetry, optimization of injected activity and acquisition time.	18f-sodium fluoride	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
33380519-1	2021	Purpose: 18F-Sodium fluoride (NaF) PET/CT has a rapid single-pass extraction and fast clearance from soft tissues resulting in a better target to background ratio.	18f-sodium fluoride	9-28	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
33380519-13	2021	Patients were injected a mean activity of 215.4+-31.3 MBq with estimated mean effective absorbed doses of 4.09+-0.59mSv for 18F-NaF PET and 7.88+-1.66 mSv for CT alone.	Fluorine-18	124-127	C-X-C motif chemokine ligand 8	Homo sapiens	128-131
33614926-6	2021	Roxithromycin increased levels of IP-10 (P = .049) and decreased levels of MCP-1 (P < .001), MIP-1alpha (P < .016), ENA-78 (P < .001), and IL-8 (P < .001).	Roxithromycin	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
33463132-9	2020	The serum concentration of IL-1beta, IL-6, and IL-8 was significantly higher in children with steroid-sensitive nephrotic syndrome (SSNS), compared with steroid-resistant nephrotic syndrome (SRNS).	Steroids	94-101	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
33463132-9	2020	The serum concentration of IL-1beta, IL-6, and IL-8 was significantly higher in children with steroid-sensitive nephrotic syndrome (SSNS), compared with steroid-resistant nephrotic syndrome (SRNS).	Steroids	153-160	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
33463132-11	2020	Our findings suggested the pathogenic role of pro-inflammatory cytokines in children with INS, of which IL-1beta, IL-6, and IL-8 were accurate biomarkers for the prediction of steroid response in these patients.	Steroids	176-183	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
33938176-0	2021	HDAC8 promotes daunorubicin resistance of human acute myeloid leukemia cells via regulation of IL-6 and IL-8.	Daunorubicin	15-27	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
32993961-11	2020	The up-regulated IL-6, IL-8, ROS, and NAPDH in the LPS-induced cells were reduced by miR-27a-3p mimic while inhibited by FOXO3.	mir-27a-3p	85-95	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
33938176-7	2021	Collectively, our data suggested that HDAC8 promotes DNR resistance of human AML cells via regulation of IL-6 and IL-8.	Daunorubicin	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
33339152-0	2020	Physicochemical Characteristics of Arginine Enriched NaF Varnish: An In Vitro Study.	Arginine	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
33335138-5	2020	Treatment of neoplastic cells with PL alone or with annexin A1 mimic peptide reduced cell proliferation and viability and modulated the expression of MCP-1 chemokine, IL-8 cytokine and genes involved in inflammatory processes.	piplartine	35-37	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
33370225-10	2022	RESULTS: In the presence of xanthine oxidase, hypoxanthine, alone and in combination with RBC supernatants, caused increases of TNF-alpha- and IL-8-positive cells after 5 hours of treatment.	Hypoxanthine	46-58	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
33390996-9	2020	Amongst these index compounds a lead chemotype: 1H-pyrazolo [3,4 d] pyrimidin-4-amine, effectively suppressed CXCL8, and TNF production by THP-1 cells when stimulated with LPS, TNF or IL-1ss.	8-aza-7-deazaadenine	48-85	C-X-C motif chemokine ligand 8	Homo sapiens	110-115
33329929-2	2020	We compared the atherosclerotic burden in non-lower extremity arteries in patients with and without PAD using 18F-sodium fluoride (NaF)-PET/CT.	18f-sodium fluoride	110-129	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
33329933-2	2020	Therefore, we hypothesize that ASCVD risk score is correlated to global cardiac microcalcification, as assessed by 18F-sodium fluoride-positron emission tomography/computed tomography (NaF-PET/CT).	18f-sodium fluoride	115-134	C-X-C motif chemokine ligand 8	Homo sapiens	185-188
33339152-1	2020	The in vitro study objectives were to investigate the effect of arginine (Arg) incorporation in a 5% sodium fluoride (NaF) varnish on its physical and chemical properties including F/Arg release.	Arginine	64-72	C-X-C motif chemokine ligand 8	Homo sapiens	118-121
33339152-1	2020	The in vitro study objectives were to investigate the effect of arginine (Arg) incorporation in a 5% sodium fluoride (NaF) varnish on its physical and chemical properties including F/Arg release.	Arginine	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	118-121
33339152-1	2020	The in vitro study objectives were to investigate the effect of arginine (Arg) incorporation in a 5% sodium fluoride (NaF) varnish on its physical and chemical properties including F/Arg release.	Sodium Fluoride	101-116	C-X-C motif chemokine ligand 8	Homo sapiens	118-121
33339152-4	2020	Molecular dynamics were simulated to identify post-dynamics total energy for NaF=Arg/Arg>NaF/Arg<NaF concentrations.	Arginine	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
33339152-4	2020	Molecular dynamics were simulated to identify post-dynamics total energy for NaF=Arg/Arg>NaF/Arg<NaF concentrations.	Arginine	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
33339152-4	2020	Molecular dynamics were simulated to identify post-dynamics total energy for NaF=Arg/Arg>NaF/Arg<NaF concentrations.	Arginine	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
33339152-6	2020	Incorporation of L-Arg in NaF varnish significantly influences physical properties ameliorating retention (p < 0.001).	Arginine	17-22	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
33339152-7	2020	L-Arg in NaF varnish institutes the Arg-F complex.	Arginine	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
33339152-7	2020	L-Arg in NaF varnish institutes the Arg-F complex.	Arginine	2-5	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
33339152-8	2020	Molecular dynamics suggests that NaF>Arg concentration denotes the stabilized environment compared to NaF<Arg (p < 0.001).	Arginine	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
33339152-9	2020	The 2% Arg-NaF exhibits periodic perennial Arg/F release and shows significantly higher integrated mean F release than NaF (p < 0.001).	Arginine	7-10	C-X-C motif chemokine ligand 8	Homo sapiens	11-14
33339152-9	2020	The 2% Arg-NaF exhibits periodic perennial Arg/F release and shows significantly higher integrated mean F release than NaF (p < 0.001).	Arginine	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	11-14
33339152-10	2020	Incorporating 2% L-arginine in 5% NaF varnish improves its physical properties and renders a stable matrix with enduring higher F/Arg release than control.	Arginine	17-27	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
33339152-10	2020	Incorporating 2% L-arginine in 5% NaF varnish improves its physical properties and renders a stable matrix with enduring higher F/Arg release than control.	Arginine	130-133	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
33199994-6	2020	In addition, DMF also decreased the expression of inflammatory factors [including IL-6, IL-8, matrix metalloproteinase (MMP)3 and MMP13] in NP cells.	Dimethyl Fumarate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
33318679-8	2021	Similar to earlier findings in AdCD40L-treated melanoma patients, IL8 plasma levels were high in the present study.	adcd40l	31-38	C-X-C motif chemokine ligand 8	Homo sapiens	66-69
33363471-6	2020	Results: At a clinically relevant concentration (1 nM), roflumilast N-oxide and roflumilast consistently reduced the release of TNF-alpha, CCL2, CCL3, CCL4, CCL5 and CXCL9 (but not CXCL1, CXCL5, CXCL8 and IL-6) from human bronchial explants.	Roflumilast	56-67	C-X-C motif chemokine ligand 8	Homo sapiens	195-200
33363471-6	2020	Results: At a clinically relevant concentration (1 nM), roflumilast N-oxide and roflumilast consistently reduced the release of TNF-alpha, CCL2, CCL3, CCL4, CCL5 and CXCL9 (but not CXCL1, CXCL5, CXCL8 and IL-6) from human bronchial explants.	n-oxide	68-75	C-X-C motif chemokine ligand 8	Homo sapiens	195-200
33363471-6	2020	Results: At a clinically relevant concentration (1 nM), roflumilast N-oxide and roflumilast consistently reduced the release of TNF-alpha, CCL2, CCL3, CCL4, CCL5 and CXCL9 (but not CXCL1, CXCL5, CXCL8 and IL-6) from human bronchial explants.	Roflumilast	80-91	C-X-C motif chemokine ligand 8	Homo sapiens	195-200
33324065-11	2020	Monocytes and osteoblasts in particular showed an increased release of IL-8 after stimulation with metal wear particles and in particular after stimulation with bacterial components and wear particles together.	Metals	99-104	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
33390947-8	2020	All GAG formulations significantly reduced the production of the pro-inflammatory cytokine IL-8 under basal conditions, while no GAG treatment suppressed cytokine production under any other condition.	Glycosaminoglycans	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
33276624-7	2020	In addition, we have evaluated whether NaF exposure might have any impact on the physiological functions of melanocytes associated with the production of melanin, which is regulated by activity of the enzyme tyrosinase.	Melanins	154-161	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
33276624-8	2020	We have also assessed if NaF exposure might induce any oxidative stress in LP and DP melanocytes, by evaluation of production of reactive oxygen species (ROS) and measurement of mitochondrial membrane potential (MMP) levels.	Reactive Oxygen Species	129-152	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
33276624-8	2020	We have also assessed if NaF exposure might induce any oxidative stress in LP and DP melanocytes, by evaluation of production of reactive oxygen species (ROS) and measurement of mitochondrial membrane potential (MMP) levels.	Reactive Oxygen Species	154-157	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
33276624-9	2020	Our results showed that HEMn-LP cells showed a higher sensitivity to NaF cytotoxicity than HEMn-DP cells, with significant cytotoxicity at concentrations >1 mM, while concentration range 0.25-1 mM were nontoxic and did not lead to oxidative stress, and also did not alter the levels of intracellular melanin or cellular tyrosinase activity, indicating that treatment up to 1 mM NaF is generally safe to melanocytes from both pigmentation phototypes.	Melanins	300-307	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
33911791-10	2020	Poly(I:C) increased the expression of psoriasis-related cytokines including tumor necrosis factor-alpha, interleukin-8, and CCL20, and KDM2A inhibitor daminozide enhanced the poly(I:C)-induced cytokine expression.	Poly I-C	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	105-118
32815062-5	2020	We report that Ad-MSCs treated by DFX resulted in a significantly enhanced mRNA expression of MAPK4 (associated with MAPK signaling pathway), INPP4B (associated with Inositol polyphosphate pathway), VEGF-A and VEGF-C (associated with cytokine-cytokine receptor pathways), IL-8 and its receptor, CXCR2 (associated with IL-8 signaling pathway).	Deferoxamine	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	272-276
32815062-5	2020	We report that Ad-MSCs treated by DFX resulted in a significantly enhanced mRNA expression of MAPK4 (associated with MAPK signaling pathway), INPP4B (associated with Inositol polyphosphate pathway), VEGF-A and VEGF-C (associated with cytokine-cytokine receptor pathways), IL-8 and its receptor, CXCR2 (associated with IL-8 signaling pathway).	Deferoxamine	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	318-322
33095981-4	2020	Here, we report that ROCK inhibition by Y-27632 reduces levels of IL-1alpha, IL-1beta, IL-6 and IL-8 secreted by senescent normal and dysplastic oral keratinocytes without affecting the permanent cell growth arrest.	Y 27632	40-47	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
33363521-7	2020	Butyrate administration significantly decreased LPS-induced rise in the clinical score of piglets and colonic histological scores and reduced the susceptibility to LPS-induced severe inflammatory response by decreasing proinflammatory (IL-1beta, IL-6, IL-8, and TNF-alpha) cytokines.	Butyrates	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	252-256
33113418-9	2020	Here, we summarize the mounting evidence where ASX is shown to exert protective effect by regulating the expression of pro-inflammatory factors IL-1beta, IL-6, IL-8 and TNF-alpha.	astaxanthine	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
33357720-5	2020	Additionally, TCDCA decreased tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, IL-8 and IL-12 through nuclear factor kappa light chain enhancer of activated B cells (NF-kappaB) activity.	Taurochenodeoxycholic Acid	14-19	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
33057826-7	2020	RESULTS: In terms of WSL prevention, sodium fluoride (NaF) varnish had the highest cumulative ranking for the short-term decalcification index (99.3%); acidulated phosphate fluoride (APF) foam ranked first for long-term incidence (96.9%), followed by difluorosilane (Dfs) varnish and high-concentration fluoride toothpaste (HFT) (79.4% and 77.4%, respectively).	Sodium Fluoride	37-52	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
33057826-7	2020	RESULTS: In terms of WSL prevention, sodium fluoride (NaF) varnish had the highest cumulative ranking for the short-term decalcification index (99.3%); acidulated phosphate fluoride (APF) foam ranked first for long-term incidence (96.9%), followed by difluorosilane (Dfs) varnish and high-concentration fluoride toothpaste (HFT) (79.4% and 77.4%, respectively).	Fluorides	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
33075509-11	2020	Following the treatment of epithelial cells with C.jejuni or C.coli, IL-8 and TNF-alpha were significantly increased compared to untreated Caco-2 cells, and the highest IL-8 expression was observed in both C.jejuni and C.coli expressing all CDTs (cdtA, cdtB, and cdtC).	1,5,9-cyclododecatriene	241-245	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
32853623-8	2020	Indeed, structural and sequence analysis evidenced for specificity of molecular interactions with cognate receptor (CXCR1) and glycosaminoglycan (heparin), thus providing evidence for a noticeable functional specificity and divergence between the two IL8 orthologs.	Heparin	146-153	C-X-C motif chemokine ligand 8	Homo sapiens	251-254
33045562-5	2020	The results showed that the in vitro treatment of monocytes from preeclamptic women with Sb downregulated the endogenous activation of NF-kappaB and the expression of surface receptors TLR4 and CD64, and reduced the synthesis of the pro-inflammatory cytokines interleukin 1 (IL-1beta), IL-6, IL-8, IL-12p70, IL-23, and tumour necrosis factor alpha (TNF-alpha) compared with cultures not treated with Sb.	Silybin	89-91	C-X-C motif chemokine ligand 8	Homo sapiens	292-296
33075509-11	2020	Following the treatment of epithelial cells with C.jejuni or C.coli, IL-8 and TNF-alpha were significantly increased compared to untreated Caco-2 cells, and the highest IL-8 expression was observed in both C.jejuni and C.coli expressing all CDTs (cdtA, cdtB, and cdtC).	CDTA	247-251	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
33075509-11	2020	Following the treatment of epithelial cells with C.jejuni or C.coli, IL-8 and TNF-alpha were significantly increased compared to untreated Caco-2 cells, and the highest IL-8 expression was observed in both C.jejuni and C.coli expressing all CDTs (cdtA, cdtB, and cdtC).	cdtc	263-267	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
32870388-9	2020	CONCLUSION: Our data suggest an important role of HSC senescence caused by DCA for the malignant biological behaviors of HCC via induction of SASP factors, particularly IL8 and TGFbeta.	Deoxycholic Acid	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	169-172
32682627-1	2020	OBJECTIVES: The purpose of the current investigation was to evaluate the diagnostic accuracy of amyloid and F-18 sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) for the detection of cardiac amyloidosis (CA) using diagnostic accuracy test.	f-18 sodium fluoride	108-128	C-X-C motif chemokine ligand 8	Homo sapiens	130-133
32662566-9	2020	beta-TmU had higher IL-8 than their controls while beta-TmN had higher IL-6 and IL-8 than their controls.	beta-tmu	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
32662566-9	2020	beta-TmU had higher IL-8 than their controls while beta-TmN had higher IL-6 and IL-8 than their controls.	beta-tmn	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
33157159-1	2020	OBJECTIVES: To investigate the remineralising and staining effects of sodium fluoride (NaF) with silver nanoparticles (AgNPs) on artificial dentine caries.	Sodium Fluoride	70-85	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
32930782-12	2020	Adequate adherence with aspirin results in an increase in ATL and IL-10 with reduced IL-8 plasma concentration.	Aspirin	24-31	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
33157159-1	2020	OBJECTIVES: To investigate the remineralising and staining effects of sodium fluoride (NaF) with silver nanoparticles (AgNPs) on artificial dentine caries.	Silver	97-103	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
33281999-8	2020	Beside this, the 18F-NaF detected SM in body segments not routinely scanned in MRI and CT.	Samarium	34-36	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
33075233-1	2020	Cadmium (Cd) is accumulated in human astrocytes and induces the production of interleukin (IL)-6 and IL-8.	Cadmium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
32731110-17	2020	Subsequently, in human osteoblasts treated with sodium fluoride (NaF), the results also showed that NaF caused low expression of miR-4755-5p and increased expression of Cyclin D1.	Sodium Fluoride	48-63	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
32731110-17	2020	Subsequently, in human osteoblasts treated with sodium fluoride (NaF), the results also showed that NaF caused low expression of miR-4755-5p and increased expression of Cyclin D1.	Sodium Fluoride	48-63	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
33174050-5	2020	ELISA showed that SFN was associated with a time- and dose-dependent reduction in poly(I:C)-stimulated production of interleukin (IL)-8, chemoattractant protein-1, IL-6, MMP-1 and MMP-3 by HCFs.	Poly I-C	82-91	C-X-C motif chemokine ligand 8	Homo sapiens	117-135
33075233-1	2020	Cadmium (Cd) is accumulated in human astrocytes and induces the production of interleukin (IL)-6 and IL-8.	Cadmium	9-11	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
32949185-10	2020	Meta-analysis including the discovery cohort, also showed that binary IL-8 levels >9.3 pg/ml from patients treated with ADT alone was prognostic for poorer OS (HR 1.8, 95% CI: 1.2-2.7, p = .007) and shorter time to CRPC (HR 1.4, 95% CI: 0.99-1.9, p = .057).	adt	120-123	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
32949185-11	2020	CONCLUSIONS: In the phase 3 CHAARTED study of men with mHSPC at ADT initiation, elevated IL-8 portended worse survival and shorter time to castration-resistant prostate cancer independent of docetaxel administration, metastatic burden, and metachronous versus de novo metastatic presentation.	adt	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
33708368-9	2020	Results: Nintedanib addition to HLFs resulted in significant elevations in Gal-3, phospho-signal transducer and activator of transcription 3 (pSTAT3), as well as IL-8 mRNA levels (p < 0.05).	nintedanib	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
33006723-3	2020	In conclusion, our study suggests that SARS-CoV-2 antibodies need to be searched in the serum and CSF in patients with GBS living in endemic areas, even in the absence of a clinically severe COVID-19 infection, and that IL-8 pathway can be relevant in Si-GBS pathogenesis.	Silicon	252-254	C-X-C motif chemokine ligand 8	Homo sapiens	220-224
32950532-4	2020	VITROCELL  cloud chamber exposure of BEAS-2B monolayers increased mitochondrial protein oxidation, expression of the antioxidant enzyme SOD2, activation of NF-kappaB, and secretion of inflammatory cytokines (IL-6 and IL-8).	beas	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
33329539-7	2020	This study demonstrates that Z-AAT variant significantly increases the expression of pro-inflammatory cytokines including CXCL-8, CXCL1, LTB4, and TNFalpha in LPS-treated macrophages.	z-aat	29-34	C-X-C motif chemokine ligand 8	Homo sapiens	122-128
33208502-6	2020	ACPA-positive B cells in blood and synovial fluid secreted increased amounts of the chemoattractant interleukin-8, which attracted neutrophils, the most abundant immune cell in arthritic joints.	arachidonylcyclopropylamide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	100-113
32961113-5	2020	This study aims to highlight for the first time the capability of theobromine in protecting the intestinal cell monolayer from a mixture of dietary oxysterols showing an inflammatory action in terms of IL-8 and MCP-1 overproduction.	Theobromine	66-77	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
33263062-0	2020	CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin.	danirixin	120-129	C-X-C motif chemokine ligand 8	Homo sapiens	0-6
33553467-9	2021	Compared with healthy blood donor controls, CCP donors had significantly higher plasma levels of interferon (IFN)-gamma, interleukin (IL)-10, IL-15, IL-21, and macrophage-inflammatory protein-1, but lower levels of IL-1RA, IL-8, IL-16, and vascular endothelial growth factor-A (P < .0014).	ccp	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	223-227
33266406-8	2020	At the same time, NaF reacts with active CaCO3 and converts into CaF2.	Calcium Carbonate	41-46	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
33244226-7	2020	Moreover, miR-486-5p expression was significantly correlated with the expression of IL-6, IL-8, TNF-alpha, and IFN-gamma.	mir-486-5p	10-20	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
33223825-6	2020	In addition, we found a positive correlation between CD4+ IL-10+ T lymphocytes and lower limb muscle strength and a negative correlation between CD4+ IL-8+ T lymphocytes and peripheral oxygen saturation and steps per day.	Oxygen	185-191	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
33170220-10	2021	Following exposure to deoxynivalenol, the secretion of interleukin (IL)-1beta, IL-6, IL-8, and/or tumor necrosis factor (TNF)-alpha in BEAS-2B cells, as well as EoL-1 cells, increased significantly.	deoxynivalenol	22-36	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
33171063-0	2020	Enterobactin induces the chemokine, interleukin-8, from intestinal epithelia by chelating intracellular iron.	Iron	104-108	C-X-C motif chemokine ligand 8	Homo sapiens	36-49
33171063-6	2020	Using three human IEC cell-lines with differential basal levels of Lcn2 (i.e. HT29 < DLD-1 < Caco-2/BBe), we demonstrated that iron-free Ent could induce a dose-dependent secretion of the pro-inflammatory chemokine, interleukin 8 (IL-8), in HT29 and DLD-1 IECs, but not in Caco-2/BBe.	Iron	127-131	C-X-C motif chemokine ligand 8	Homo sapiens	216-229
33171063-6	2020	Using three human IEC cell-lines with differential basal levels of Lcn2 (i.e. HT29 < DLD-1 < Caco-2/BBe), we demonstrated that iron-free Ent could induce a dose-dependent secretion of the pro-inflammatory chemokine, interleukin 8 (IL-8), in HT29 and DLD-1 IECs, but not in Caco-2/BBe.	Iron	127-131	C-X-C motif chemokine ligand 8	Homo sapiens	231-235
33171063-7	2020	Ent-induced IL-8 secretion was dependent on chelation of the labile iron pool and on the levels of intracellular Lcn2.	Iron	68-72	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
33171063-8	2020	Accordingly, IL-8 secretion by Ent-treated HT29 cells could be substantially inhibited by either saturating Ent with iron or by adding exogenous Lcn2 to the cells.	Iron	117-121	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
33171063-11	2020	Intriguingly, formyl peptide receptor (FPR) antagonists (i.e. Boc2, cyclosporine H) abrogated Ent-induced IL-8, implicating that such IEC response could be, in part, dependent on FPR.	boc2	62-66	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
33171063-11	2020	Intriguingly, formyl peptide receptor (FPR) antagonists (i.e. Boc2, cyclosporine H) abrogated Ent-induced IL-8, implicating that such IEC response could be, in part, dependent on FPR.	cyclosporin H	68-82	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
33224901-7	2020	sEVs from TVV-negative but not TVV-positive parasites cultured alone caused NF-kappaB activation and increase of IL-8 and RANTES expression by uterine endocervical cells, which provide innate immune defense at the gate to the upper reproductive tract.	tvv	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
32975550-6	2020	Moreover, when PBMC were cultured with degradable Mg, the expression of migration/wound healing related cytokines (interleukin 8, granulocyte-macrophage colony-stimulating factor, monocyte chemoattractant protein 1 and macrophage inflammatory protein 1alpha/beta) was upregulated, accompanied by an increase in the migration ability of HUCPV (cell scratch assay).	Magnesium	50-52	C-X-C motif chemokine ligand 8	Homo sapiens	115-178
33174867-5	2020	Our findings indicate that pretreatment with memantine significantly reduced the expression of interleukin (IL)-6 and IL-8, which are both serum markers if AMI severity.	Memantine	45-54	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
32777211-9	2020	On the other hand, cell area, circularity or aspect ratio were affected by staurosporine in CXCL8 or CXCL10-activated cells, demonstrating a role of PKCalpha in the rearrangement of the cytoskeleton regardless of the effect on the migration.	Staurosporine	75-88	C-X-C motif chemokine ligand 8	Homo sapiens	92-97
33251227-16	2020	In multiple linear regression analysis, both peak IL-6 (p = 0.002) and IL-8 (p = 0.01) concentrations remained significantly correlated with GFRiohexol, without collinearity.	gfriohexol	141-151	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
33145738-2	2020	This exploratory study sought to assess the potential of hybrid positron-emission tomography (PET)/magnetic resonance imaging (MRI) using 18F-sodium fluoride (18F-NaF) to check simultaneously 18F-NaF uptake, a marker of microcalcifications, and morphological criteria of vulnerability.	18f-sodium fluoride	138-157	C-X-C motif chemokine ligand 8	Homo sapiens	163-166
33145738-9	2020	We found a positive correlation between 18F-NaF uptake and calcium plaque volume and ratio but not with circulating tissue-nonspecific alkaline phosphatase (TNAP) activity and inorganic pyrophosphate (PPi) levels.	Calcium	59-66	C-X-C motif chemokine ligand 8	Homo sapiens	44-47
33145838-4	2021	We observed inhibition of IL-6 and CXCL8 secretion from both lung fibroblast models by dexamethasone (maximal inhibition 40 - 90%) and the p38 MAPK inhibitor BIRB (maximal inhibition 30 - 60%), used alone and evidence of increased anti-inflammatory effects when used in combination.	Dexamethasone	87-100	C-X-C motif chemokine ligand 8	Homo sapiens	35-40
33145838-4	2021	We observed inhibition of IL-6 and CXCL8 secretion from both lung fibroblast models by dexamethasone (maximal inhibition 40 - 90%) and the p38 MAPK inhibitor BIRB (maximal inhibition 30 - 60%), used alone and evidence of increased anti-inflammatory effects when used in combination.	birb	158-162	C-X-C motif chemokine ligand 8	Homo sapiens	35-40
32889778-10	2020	Icaritin treatment-induced dynamics of serum cytokines IL-6, IL-8, IL-10 and TNF-alpha, and soluble immune checkpoint proteins TIM3, LAG3, CD28, CD80, and CTLA-4 were assessed.	icaritin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
32730122-0	2020	Salivary fluoride concentration and retention after rinsing with 0.05 and 0.2% sodium fluoride (NaF) compared with a new high F rinse containing 0.32% NaF.	Fluorides	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	96-99
33222465-7	2020	Similarly,4-Octyl Itaconate inhibited the secretion of inflammatory cytokines (TNF-alpha, IL-1beta, IL6, and IL-8) by MCs, which was induced by LPS, but SIRT4 knockdown decreases the inhibition of 4-Octyl Itaconate.	4-Octyl Itaconate	10-27	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
33146789-10	2021	In addition, using the ROS inhibitor N-acetyl-L-cysteine (NAC), we observed abrogated mRNA expression of several ARPs and production of inflammatory cytokines/chemokines (IL-6, IL-8, MCP-1, and CCL-5) in the CSE-challenged cells suggesting an important role of ROS in regulating CSE-induced autophagy.	ros	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
33146789-10	2021	In addition, using the ROS inhibitor N-acetyl-L-cysteine (NAC), we observed abrogated mRNA expression of several ARPs and production of inflammatory cytokines/chemokines (IL-6, IL-8, MCP-1, and CCL-5) in the CSE-challenged cells suggesting an important role of ROS in regulating CSE-induced autophagy.	Acetylcysteine	37-56	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
33146789-10	2021	In addition, using the ROS inhibitor N-acetyl-L-cysteine (NAC), we observed abrogated mRNA expression of several ARPs and production of inflammatory cytokines/chemokines (IL-6, IL-8, MCP-1, and CCL-5) in the CSE-challenged cells suggesting an important role of ROS in regulating CSE-induced autophagy.	Acetylcysteine	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
32236723-9	2020	DeltaZ of hydroxypropyl-beta-cyclodextrin:TiF4 72 h was higher than negative control, hydroxypropyl-beta-cyclodextrin, gamma-cyclodextrin, gamma-cyclodextrin:TiF4 1 2 h, gamma-cyclodextrin:TiF4 72 h, and NaF (p < 0.05) and similar to TiF4 and hydroxypropyl-beta-cyclodextrin:TiF4 12 h (p > 0.05).	2-Hydroxypropyl-beta-cyclodextrin	10-41	C-X-C motif chemokine ligand 8	Homo sapiens	204-207
33139632-6	2020	Vadadustat caused a marked decrease in the secretion of IL6 (by 51%), HGF (by 47%), CCL7 (MCP3) (by 42%) and CXCL8 (by 40%).	vadadustat	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	109-114
32236723-9	2020	DeltaZ of hydroxypropyl-beta-cyclodextrin:TiF4 72 h was higher than negative control, hydroxypropyl-beta-cyclodextrin, gamma-cyclodextrin, gamma-cyclodextrin:TiF4 1 2 h, gamma-cyclodextrin:TiF4 72 h, and NaF (p < 0.05) and similar to TiF4 and hydroxypropyl-beta-cyclodextrin:TiF4 12 h (p > 0.05).	titanium tetrafluoride	42-46	C-X-C motif chemokine ligand 8	Homo sapiens	204-207
32946851-8	2020	Besides, patients with higher fasting plasma glucose (FPG) had higher IL-6, IL-8, CRP, and mortality.	Glucose	45-52	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
32736336-10	2020	The expression of CXCL8 induced by WNT5A has been significantly reduced by MEK inhibitor, binimetinib.	binimetinib	90-101	C-X-C motif chemokine ligand 8	Homo sapiens	18-23
32769069-7	2020	EGCG has been shown to prevent production and mRNA expression of TSLP, interleukin (IL)-1beta, IL-6, and IL-8 by RANKL without cytotoxicity.	epigallocatechin gallate	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
32629210-0	2020	Upregulation of miR-200c-3p induced by NaF promotes endothelial apoptosis by activating Fas pathway.	mir-200c-3p	16-27	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
32629210-5	2020	And miR-200c-3p was found to be upregulated in NaF treated HUVECs.	mir-200c-3p	4-15	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
32815403-9	2020	Paclitaxel exposure reduced IL-8 levels in cancer cell lines, whilst no cytotoxic effect was observed in all cell lines at treatment concentration levels (<= 0.1% (w/v) paclitaxel in silicone).	Paclitaxel	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
32246208-1	2020	AIM: To compare the effects of high-dose therapy (HDT consisting of high-dose chemotherapy followed by autologous stem cell transplantation) and conventional-dose chemotherapy (non-HDT) on the uptake of 18F-sodium fluoride (NaF) in the whole bone, pelvis, and femoral neck of multiple myeloma (MM) patients.	Sodium Fluoride	207-222	C-X-C motif chemokine ligand 8	Homo sapiens	224-227
32898511-9	2020	LPS, Poly I:C and TNFalpha significantly induce the secretion of IL-6 and IL-8 at all tested time points.	Poly I-C	5-13	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
32968431-6	2020	Isoflurane pretreatment decreased HR-induced IL-6 and IL-8 expression levels in A549 cells.	Isoflurane	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
31729901-7	2020	Moreover, p38/MAPK inhibitor SB203580 and NF-kappaB inhibitor BAY11-7082 could block the IL-8 up-regulated by X-rays but JNK inhibitor SP600125, ERK inhibitor U0126, ROS Scavenger NAC could not inhibit this phenomenon.Conclusions: X-rays could induce IL-8 production in lung cancer cells, which may be related to the activation of p38/MAPK and NF-kappaB signaling pathway, providing a new point for elucidating the mechanism of radiation pneumonitis.	SB 203580	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
33182021-13	2020	Knocking down NEAT1 expression with an ASO suppressed the expression of CXCL8 and TNF-alpha in PMA/ionomycin-stimulated Jurkat cells.	Tetradecanoylphorbol Acetate	95-98	C-X-C motif chemokine ligand 8	Homo sapiens	72-77
33182021-13	2020	Knocking down NEAT1 expression with an ASO suppressed the expression of CXCL8 and TNF-alpha in PMA/ionomycin-stimulated Jurkat cells.	Ionomycin	99-108	C-X-C motif chemokine ligand 8	Homo sapiens	72-77
31729901-7	2020	Moreover, p38/MAPK inhibitor SB203580 and NF-kappaB inhibitor BAY11-7082 could block the IL-8 up-regulated by X-rays but JNK inhibitor SP600125, ERK inhibitor U0126, ROS Scavenger NAC could not inhibit this phenomenon.Conclusions: X-rays could induce IL-8 production in lung cancer cells, which may be related to the activation of p38/MAPK and NF-kappaB signaling pathway, providing a new point for elucidating the mechanism of radiation pneumonitis.	SB 203580	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	251-255
31729901-7	2020	Moreover, p38/MAPK inhibitor SB203580 and NF-kappaB inhibitor BAY11-7082 could block the IL-8 up-regulated by X-rays but JNK inhibitor SP600125, ERK inhibitor U0126, ROS Scavenger NAC could not inhibit this phenomenon.Conclusions: X-rays could induce IL-8 production in lung cancer cells, which may be related to the activation of p38/MAPK and NF-kappaB signaling pathway, providing a new point for elucidating the mechanism of radiation pneumonitis.	3-(4-methylphenylsulfonyl)-2-propenenitrile	62-72	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
32660201-8	2020	Conclusion: The obtained results demonstrate that IL-8 and IL-15 could be proposed as potential markers in their optimal cut-off points for distinguishing CD from the NCGS and the healthy control.	Cadmium	155-157	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
31729901-7	2020	Moreover, p38/MAPK inhibitor SB203580 and NF-kappaB inhibitor BAY11-7082 could block the IL-8 up-regulated by X-rays but JNK inhibitor SP600125, ERK inhibitor U0126, ROS Scavenger NAC could not inhibit this phenomenon.Conclusions: X-rays could induce IL-8 production in lung cancer cells, which may be related to the activation of p38/MAPK and NF-kappaB signaling pathway, providing a new point for elucidating the mechanism of radiation pneumonitis.	3-(4-methylphenylsulfonyl)-2-propenenitrile	62-72	C-X-C motif chemokine ligand 8	Homo sapiens	251-255
31729901-7	2020	Moreover, p38/MAPK inhibitor SB203580 and NF-kappaB inhibitor BAY11-7082 could block the IL-8 up-regulated by X-rays but JNK inhibitor SP600125, ERK inhibitor U0126, ROS Scavenger NAC could not inhibit this phenomenon.Conclusions: X-rays could induce IL-8 production in lung cancer cells, which may be related to the activation of p38/MAPK and NF-kappaB signaling pathway, providing a new point for elucidating the mechanism of radiation pneumonitis.	U 0126	159-164	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
31729901-7	2020	Moreover, p38/MAPK inhibitor SB203580 and NF-kappaB inhibitor BAY11-7082 could block the IL-8 up-regulated by X-rays but JNK inhibitor SP600125, ERK inhibitor U0126, ROS Scavenger NAC could not inhibit this phenomenon.Conclusions: X-rays could induce IL-8 production in lung cancer cells, which may be related to the activation of p38/MAPK and NF-kappaB signaling pathway, providing a new point for elucidating the mechanism of radiation pneumonitis.	N-acetylcysteine lysinate	180-183	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
32557721-8	2020	Results indicated that pre-treatment with BaP increased expression of IL-8 in house dust mite-activated EOL-1, BEAS-2B, and A549 cells.	Benzo(a)pyrene	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
32614486-9	2020	Similar 18F-NaF tracer uptake patterns were observed between 3 and 12 weeks for the BCP-coated TPU and titanium implants, but not for the uncoated implants.	hydroxyapatite-beta tricalcium phosphate	84-87	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
32162384-5	2020	Treatment with teneligliptin significantly reduced IL-1beta-induced expression of tumor necrosis factor alpha, IL-6, and IL-8, generation of reactive oxygen species, increase in metalloproteinase 3 (MMP-3) and MMP-13, reduction of tissue inhibitors of matrix metalloproteinase 1 (TIMP-1) and TIMP-2, release of lactate dehydrogenase, and activation of the mitogen-activated protein kinase p38 and nuclear factor kappaB intracellular signaling pathways, among other things.	3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine	15-28	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
32614486-9	2020	Similar 18F-NaF tracer uptake patterns were observed between 3 and 12 weeks for the BCP-coated TPU and titanium implants, but not for the uncoated implants.	Titanium	103-111	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
32830258-8	2020	CDEC exposed to MCM from IgA1-stimulated THP-1 cells (THP-1-IgA-MCM) exhibited markedly increased expression of neutrophil-associated gelatinase (NGAL) and proinflammatory cytokinesinterleukin (IL)-1beta, tumour necrosis factor-alpha, IL-6 and IL-8 compared with MCM from non-IgA-stimulated THP-1 cells (THP-1-MCM).	CDEC	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	244-248
32979781-11	2020	When conditions of ROS decrease were experienced, an increase in LL37 antimicrobial peptide and a modulation of IL-8 inflammatory response were noted, suggesting improvement in acne signs.	Reactive Oxygen Species	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
33130987-9	2020	Autocrine GH-mediated IL-6, IL-8, IL-10 expressions were downregulated by curcumin treatment.	Curcumin	74-82	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
32898874-7	2020	However, an inhibitory effect of the identified quercetin-3-O-rhamnoside and its aglycone, quercetin, on the release of IL-8 and IL-6 could not be demonstrated.	quercitrin	48-72	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
32985128-7	2020	RESULTS: Children exposed to higher IL-1beta, IL-6, IL-8, and IL-10 concentrations had lower BMIz at birth but higher BMIz during childhood.	bmiz	93-97	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
32985128-7	2020	RESULTS: Children exposed to higher IL-1beta, IL-6, IL-8, and IL-10 concentrations had lower BMIz at birth but higher BMIz during childhood.	bmiz	118-122	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
32985128-8	2020	Higher concentrations of IL-8 and IL-1beta were also associated with higher BMIz during infancy (B per log increase in IL-8 = 0.04; 95% CI: 0.02 to 0.07; B per log increase in IL-1beta = 0.03; 95% CI: 0.001 to 0.06).	bmiz	76-80	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
32985128-8	2020	Higher concentrations of IL-8 and IL-1beta were also associated with higher BMIz during infancy (B per log increase in IL-8 = 0.04; 95% CI: 0.02 to 0.07; B per log increase in IL-1beta = 0.03; 95% CI: 0.001 to 0.06).	bmiz	76-80	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
32898874-7	2020	However, an inhibitory effect of the identified quercetin-3-O-rhamnoside and its aglycone, quercetin, on the release of IL-8 and IL-6 could not be demonstrated.	scutellarein	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
32898874-7	2020	However, an inhibitory effect of the identified quercetin-3-O-rhamnoside and its aglycone, quercetin, on the release of IL-8 and IL-6 could not be demonstrated.	Quercetin	48-57	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
32920000-6	2020	Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases.	Chloroquine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	83-88
33139990-1	2020	Background: The present study aimed to investigate whether dual-phase F-18 sodium-fluoride (NaF) positron emission tomography/computed tomography (PET/CT) could improve the diagnostic accuracy of detecting bone metastasis in cancer patients with a solitary bone lesion compared to conventional F-18 NaF PET/CT.	Sodium Fluoride	75-90	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
33139990-1	2020	Background: The present study aimed to investigate whether dual-phase F-18 sodium-fluoride (NaF) positron emission tomography/computed tomography (PET/CT) could improve the diagnostic accuracy of detecting bone metastasis in cancer patients with a solitary bone lesion compared to conventional F-18 NaF PET/CT.	Sodium Fluoride	75-90	C-X-C motif chemokine ligand 8	Homo sapiens	299-302
32920000-6	2020	Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases.	Hydroxychloroquine	12-30	C-X-C motif chemokine ligand 8	Homo sapiens	83-88
32918926-5	2020	Interestingly, we found that lebecetin reduced the levels of the pro-inflammatory cytokines TNF-alpha, IL-6, and IL-8 while it partially increased LPS-induced secretion of the immunomodulatory cytokine IL-10.	lebecetin	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
32920000-6	2020	Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases.	Azithromycin	33-45	C-X-C motif chemokine ligand 8	Homo sapiens	83-88
32920000-6	2020	Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases.	Chloroquine	19-30	C-X-C motif chemokine ligand 8	Homo sapiens	83-88
33114240-9	2020	One of the latter compounds-7,10-diisobutyryloxy-8,9-epoxythymyl isobutyrate-at concentrations 0.5, 1.0 and 2.5 muM, significantly reduced IL-8, IL-1beta and CCL2 excretion by LPS-stimulated human neutrophils.	7,10-diisobutyryloxy-8,9-epoxythymyl isobutyrate	28-76	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
32898567-5	2020	The upregulation of TAZ increased the expression of IL-8 in HCC/CDDP and HCC/Dox cells.	Cisplatin	64-68	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
33120982-11	2020	18F-NaF wall uptake correlated with CS in the femoral arteries, and aortic wall PWV.	Cesium	36-38	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
33107041-12	2021	Therefore, the mRNA levels of MCP-1 and IL-8 in hPDLCs were significantly decreased through the vitamin D pathway.	Vitamin D	96-105	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
32898567-5	2020	The upregulation of TAZ increased the expression of IL-8 in HCC/CDDP and HCC/Dox cells.	Doxorubicin	77-80	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
33194843-8	2020	There was some variation between the human isolates, but the water isolate seemed to display the greatest pathogenic potential, demonstrated by the highest levels of virulence gene expression, adhesion to epithelial cells and IL-8 induction.	Water	61-66	C-X-C motif chemokine ligand 8	Homo sapiens	226-230
33344897-6	2020	AGN 225660 inhibited RANTES, IL-8, and MCP-1 secretion by at least 50%, from TNFalpha activated human macrophages.	agn 225660	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
33114438-13	2020	As a result, we identified that Ac2-26 significantly decreased the expression of TNF-alpha/IFN-gamma-stimulated pro-inflammatory chemokines, including IL-1beta, IL-6, IL-8, MDC, TARC, and TNF-alpha, by inhibiting the activation of MAPK, NF-kappaB, and JAK/STAT pathway in TNF-alpha/IFN-gamma-stimulated HaCaT human keratinocytes.	annexin A1 peptide (2-26)	32-38	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
33144864-12	2020	Namely, similar to BM-MSCs, SV-MSCs secreted increased amount of IL-6 and IL-8 after 12- or 24-hour treatment with LPS, PolyI:C, TNFalpha, or IL-1beta, compared to untreated controls.	Poly I-C	120-127	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
33192540-4	2020	Imaging with positron emission tomography/computed tomography (PET/CT) using 18F-fluorodeoxyglucose (FDG) and 18F-sodium fluoride (NaF) can non-invasively assess arterial inflammation and microcalcification, respectively.	18f-sodium fluoride	110-129	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
33192540-6	2020	By contrast, NaF uptake reflects the exchange of hydroxyl groups of hydroxyapatite crystals for fluoride producing fluorapatite, a key biochemical step in calcification of atherosclerotic plaque.	Durapatite	68-82	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
33192540-6	2020	By contrast, NaF uptake reflects the exchange of hydroxyl groups of hydroxyapatite crystals for fluoride producing fluorapatite, a key biochemical step in calcification of atherosclerotic plaque.	Fluorides	96-104	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
33192540-6	2020	By contrast, NaF uptake reflects the exchange of hydroxyl groups of hydroxyapatite crystals for fluoride producing fluorapatite, a key biochemical step in calcification of atherosclerotic plaque.	fluorapatite	115-127	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
33092250-1	2020	The evidence on atherosclerosis imaging with 18F-sodium-fluoride (NaF) positron emission tomography (PET) is hotly debated because of the different patient characteristics, methodology, vascular beds, etc.	18f-sodium-fluoride	45-64	C-X-C motif chemokine ligand 8	Homo sapiens	66-69
33068297-10	2021	Human VF fibroblasts encapsulated in alginate microspheres induced the production of interleukin (IL)-8 and IL-4 at 24 hours.	Alginates	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	85-103
33078100-9	2020	Both TNFalpha and IL-8 in the aqueous humor of PAH group were transiently elevated 1wk post-operation and recovered to normal levels at 1 and 3mo post-operation.	p-Aminohippuric Acid	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
33083468-10	2020	Conclusion: Dexmedetomidine can reduce the level of plasma IL-8 and upregulate the expression of AQP1 in the lung tissue of patients undergoing thoracoscopic surgery under one-lung ventilation, but it has no significant effect on the incidence of postoperative PPCs.	Dexmedetomidine	12-27	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
32829163-6	2020	Similar to the known CXCR2 antagonist SB265610, compound 52 inhibited CXCL8-CXCR2 induced phosphorylation of ERK1/2.	1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea	38-46	C-X-C motif chemokine ligand 8	Homo sapiens	70-75
32829163-7	2020	TUTP compounds also inhibited CXCL8-mediated cell migration and showed synergy with doxorubicin in ovarian cancer cells, thereby supporting TUTPs as promising compounds for cancer treatment.	tutp	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	30-35
32829163-7	2020	TUTP compounds also inhibited CXCL8-mediated cell migration and showed synergy with doxorubicin in ovarian cancer cells, thereby supporting TUTPs as promising compounds for cancer treatment.	tutps	140-145	C-X-C motif chemokine ligand 8	Homo sapiens	30-35
33066024-12	2020	Quininib significantly downregulated IL-2 and IL-6 in Mel285 cells (p < 0.05) but significantly upregulated IL-10, IL-1beta, IL-2 (p < 0.0001), IL-13, IL-8 (p < 0.001), IL-12p70 and IL-6 (p < 0.05) in OMM2.5 cells.	quininib	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
33066647-6	2020	The in vitro results showed that naringenin significantly attenuated CSE-induced up-regulation of IL-8 and TNF-alpha.	naringenin	33-43	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
32856891-10	2020	Overall, NaF is a better salt than NaCl by having 2.3-fold higher sensitivity, which was confirmed in a DNA sensing assay.	Salts	25-29	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
32618142-17	2020	Further multivariable analysis showed that phenylalanine >= 112 muM predicted death over 1 year independently of age, APACHE II and SOFA scores, atrial fibrillation, C-reactive protein, cholesterol, pre-albumin, transferrin, and interleukin-8 and interleukin-10.	Phenylalanine	43-56	C-X-C motif chemokine ligand 8	Homo sapiens	229-242
32726657-11	2020	NAC significantly decreased malondialdehyde (MDA) (SMD = -1.44 mumol/L; 95% CI: -2.05, -0.84; P < 0.001), IL-8 (WMD = -2.56 pg/ml; 95% CI: -3.89, -1.23; P < 0.001) and homocysteine (WMD = -1.45 pg/ml; 95% CI: -2.74, -0.17; P = 0.027) levels.	Acetylcysteine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
32726657-14	2020	NAC significantly decreased MDA, IL-8, and homocysteine levels.	Acetylcysteine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
32598947-7	2020	The ability of the colchicine analogues with the predicted highest affinity for betaVI-tubulin to dampen neutrophil responses to MSU was determined with in vitro assays that measure MSU-induced production of ROS, release of IL-1 and IL-8, and the increase in the concentration of cytoplasmic calcium.	Colchicine	19-29	C-X-C motif chemokine ligand 8	Homo sapiens	233-237
32232846-10	2020	The proportion of leukaemic cells in bone marrow on infusion day and the peaks of IL-6, TNF-alpha and IL-8 levels were correlated with CRS levels.	3-cresol	135-138	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
32814232-8	2020	RESULTS: We found that punicalagin and curcumin significantly supressed TNF-induced pro-inflammatory cytokine (IL1A, IL1B, and IL6) and chemokine (CCL2-4, CXCL1, CXCL5 and CXCL8) expression in human placenta, VAT and SAT.	Curcumin	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	172-177
32589777-8	2020	The concentration of CBM (12.5%) inhibited the production of IL-6 (p<0.05), IL-8 (p<0.01) and MCP-1 (p<0.005) and augmented the production of IL-10 (p<0.05).	N-(4-chlorobenzoyl)melatonin	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
33107903-5	2020	Results: In laser-induced CNV, fursultiamine significantly decreased vascular leakage and lesion size, as well as the numbers of both choroidal and retinal inflammatory cytokines, including IL-1beta, IL-6, IL-8, and TNF-alpha.	Fursultiamin	31-44	C-X-C motif chemokine ligand 8	Homo sapiens	206-210
33107903-7	2020	Furthermore, fursultiamine suppressed LPS-induced upregulation of IL-6, IL-8, and monocyte chemoattractant protein-1 in a dose-dependent and time-dependent manner in primary hRPE cells.	Fursultiamin	13-26	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
33456597-9	2020	Addition of synbiotic to allopurinol leads to a blood uric acid lowering (18.7% vs. 13.3%, p <0.01), CRP reduction (75% vs. 26.3%, p <0.01) as well as decrease of cytokines level: IL-1beta, IL-6, IL-8, IL-10 and TNFalpha (all p <0.001).	Allopurinol	25-36	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
32735798-13	2020	All agonists induced the secretion of IL-1ss, IL-8, and TNFalpha in microglia cells while in real-time PCR, LPS and Pam induced the expression of IL-6, IL-1ss and iNOS.	pam	116-119	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
32578917-9	2020	Aggregation, soft-agar, clonogenic, and scratch assays as well as gene expression analysis collectively confirmed that 4-FPAC minimizes the metastatic property of A549 by downregulating Snail, matrix metalloproteinase 9, and interleukin-8.	4-fpac	119-125	C-X-C motif chemokine ligand 8	Homo sapiens	225-238
33159774-0	2020	Incidental brain metastasis of breast cancer detected on 18F-Sodium Fluoride (NaF) PET-CT. 18F- Sodium Fluoride (NaF) is an excellent bone imaging agent used for skeletal staging but can also be localized in extra osseous calcifying lesions.	18f-sodium fluoride	57-76	C-X-C motif chemokine ligand 8	Homo sapiens	78-81
33159774-0	2020	Incidental brain metastasis of breast cancer detected on 18F-Sodium Fluoride (NaF) PET-CT. 18F- Sodium Fluoride (NaF) is an excellent bone imaging agent used for skeletal staging but can also be localized in extra osseous calcifying lesions.	18f-sodium fluoride	57-76	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
33159774-0	2020	Incidental brain metastasis of breast cancer detected on 18F-Sodium Fluoride (NaF) PET-CT. 18F- Sodium Fluoride (NaF) is an excellent bone imaging agent used for skeletal staging but can also be localized in extra osseous calcifying lesions.	18f- sodium fluoride	91-111	C-X-C motif chemokine ligand 8	Homo sapiens	78-81
33159774-0	2020	Incidental brain metastasis of breast cancer detected on 18F-Sodium Fluoride (NaF) PET-CT. 18F- Sodium Fluoride (NaF) is an excellent bone imaging agent used for skeletal staging but can also be localized in extra osseous calcifying lesions.	18f- sodium fluoride	91-111	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
32794617-4	2020	Uric acid sodium salt induces caspase-1 activation, cell death, and the expression of proinflammatory cytokines, including IL-1alpha, IL-6, and IL-8, in the human keratinocyte HOK-16B cell line.	Uric acid sodium salt	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
32768370-1	2020	In recent years, 18F-Sodium Fluoride (NaF)-PET/CT has seen its role in the detection and management of osteoporosis increase.	18f-sodium fluoride	17-36	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
32957145-2	2020	In initial investigations, the dichloromethane extract from the aerial parts of S. orientalis showed distinct inhibitory effects on the release of interleukin-8 in human neutrophils.	Methylene Chloride	31-46	C-X-C motif chemokine ligand 8	Homo sapiens	147-160
32957145-7	2020	Three germacranolide sesquiterpene lactones inhibited interleukin-8 production with IC50 values between 1.6 and 6.3 microM, respectively, and tumor necrosis factor-alpha production with IC50 values between 0.9 and 3.3 microM, respectively.	germacranolide	6-20	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
32739154-5	2020	For the peroxynitrite-modified proteins, we found a strongly enhanced activation of TLR4 and the pro-inflammatory transcription factor NF-kappaB in stable reporter cell lines as well as increased mRNA expression and secretion of the pro-inflammatory cytokines TNF-alpha, IL-1beta, and IL-8 in human monocytes (THP-1).	Peroxynitrous Acid	8-21	C-X-C motif chemokine ligand 8	Homo sapiens	285-289
32957145-7	2020	Three germacranolide sesquiterpene lactones inhibited interleukin-8 production with IC50 values between 1.6 and 6.3 microM, respectively, and tumor necrosis factor-alpha production with IC50 values between 0.9 and 3.3 microM, respectively.	sesquiterpene lactones	21-43	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
32730864-8	2020	Abacavir, carbamazepine and clozapine gave positive results with CD86 upregulation and/or IL-8 release, with abacavir also inducing HLA-DR.	abacavir	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
32730864-8	2020	Abacavir, carbamazepine and clozapine gave positive results with CD86 upregulation and/or IL-8 release, with abacavir also inducing HLA-DR.	Carbamazepine	10-23	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
32730864-8	2020	Abacavir, carbamazepine and clozapine gave positive results with CD86 upregulation and/or IL-8 release, with abacavir also inducing HLA-DR.	Clozapine	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
32783763-6	2020	CBNPs induced a significant increase in the expressions of IL-8 and IL-6, accompanied by a high level of intracellular HDAC6 mRNA when compared with a blank control group (p < 0.05).	cbnps	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
32840447-12	2020	A limited amount of IL-6 and IL-8 was released by ionomycin-exposed HMC-1 cells.	Ionomycin	50-59	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
32998161-11	2020	In presence of IL-1beta, TCs showed an upregulation of ADORA2A, SCX and COL3A1 expression and an increase of IL-6, IL-8, PGE2 and VEGF secretion.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
32991579-4	2020	Interaction of the above-mentioned alkaloids with acetylcholinesterase enzyme and interleukins IL-6 and IL-8 was investigated in silico by molecular docking.	Alkaloids	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
33093965-8	2020	Results: There was a significant difference between the mean vitamin 25(OH)D (p = 0.001) and IL-8 levels (p = 0.002) before and after vitamin D supplementation.	Vitamin D	134-143	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
33003647-11	2020	MiR-342-3p was negatively correlated with TIMP-1, IL-6, IL-8, TNF-alpha, HbA1c and CXCR2, whilst miR-342-5p was negatively correlated with TIMP-1, IL-6, IL-8 and HbA1c.	mir-342-3p	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
33093965-0	2020	Modulation of Interleukin-8 Production by Vitamin D Supplementation in Indonesian Patients with Diabetic Polyneuropathy: A Randomized Clinical Trial.	Vitamin D	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
33093965-1	2020	Objectives: We sought to assess the modulation of interleukin-8 (IL-8) production by vitamin D supplementation in Indonesian patients with diabetic polyneuropathy (DPN).	Vitamin D	85-94	C-X-C motif chemokine ligand 8	Homo sapiens	50-63
33093965-1	2020	Objectives: We sought to assess the modulation of interleukin-8 (IL-8) production by vitamin D supplementation in Indonesian patients with diabetic polyneuropathy (DPN).	Vitamin D	85-94	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
32991579-11	2020	Stepharine inhibited considerably the production of IL-8 in comparison to 5-N-methylmaytenine, which showed a dose dependent action (inhibitory at the IC50 dose, and stimulatory at the twofold IC50 one).	stepharine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
32993127-5	2020	LPS alone or together with cyclic dinucleotides elevated IL-8 levels.	cyclic dinucleotides	27-47	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
32975624-14	2021	Additionally, SSNB and ANB with DEX tended to result in a later mean timing of rebound pain accompanied by significant changes in IL-8, IL-1beta, and serotonin levels within 48 h after the operation.	ssnb	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
33101052-10	2020	We also found that ouabain (100 nM) promoted the secretion of IL-6, IL-8, GM-CSF, and TNF-alpha from the skeletal muscle cells of healthy subjects, and the secretion of GM-CSF from cells of subjects with the type 2 diabetes.	Ouabain	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
32975624-14	2021	Additionally, SSNB and ANB with DEX tended to result in a later mean timing of rebound pain accompanied by significant changes in IL-8, IL-1beta, and serotonin levels within 48 h after the operation.	alpha-naphthyl butyrate	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
32975624-14	2021	Additionally, SSNB and ANB with DEX tended to result in a later mean timing of rebound pain accompanied by significant changes in IL-8, IL-1beta, and serotonin levels within 48 h after the operation.	Dexmedetomidine	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
32973190-10	2020	In human corneal epithelial cells, secretion of IL-6 and IL-8 in both apical and basolateral media was promoted significantly by perfluorooctanoic acid treatment.	perfluorooctanoic acid	129-151	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
32610185-5	2020	Additionally, TJ and siMyD88 significantly attenuated cell migration and invasion, inhibited EMT-like progression and reduced cytokine (IL-6, IL-8, TGF-beta1 and TNF-alpha) secretion induced by LPS.	simyd88	21-28	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
32794529-8	2020	Moreover, as compared to the control group, sows and newborn piglets in the Na2SeO3 and HMSeBA groups had a lower serum interleukin-6 (p < 0.05) concentration, and placentas in the HMSeBA group had lower IL-1beta, IL-6 and IL-8 gene expression (p < 0.05).	na2seo3	76-83	C-X-C motif chemokine ligand 8	Homo sapiens	223-227
33230450-7	2020	Mechanically, miR-146b-5p suppressed nuclear factor kappaB (NF-kappaB) activity and NF-kappaB-related IL-6 and IL-8 production by targeting IRAK1.	mir-146b-5p	14-25	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
32977686-9	2020	Finally, the inflammatory response in the HGF-1 cells after their exposure to GSH-AgNPs was measured as the production of immune markers (interleukins 6 and 8 (IL-6 and IL-8) and tumor necrosis factor-alpha (TNF-alpha)).	gsh-agnps	78-87	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
32961947-6	2020	The hexane fraction exerted the most potent anti-inflammatory effect, suppressing C. acnes-induced interleukin-8 (IL-8) production by 36%.	Hexanes	4-10	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
32961947-7	2020	The ethanol-soluble fraction (ESF), which was separated from the n-hexane fraction, significantly inhibited C. acnes-induced activation of mitogen-activated protein kinase (MAPK)-mediated cellular IL-8 production.	Ethanol	4-11	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
32961947-7	2020	The ethanol-soluble fraction (ESF), which was separated from the n-hexane fraction, significantly inhibited C. acnes-induced activation of mitogen-activated protein kinase (MAPK)-mediated cellular IL-8 production.	n-hexane	65-73	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
32961947-10	2020	Using co-cultures of C. acnes and THP-1 cells, beta-ionone, a compound of the ESF, reduced the production of IL-1beta and IL-8 up to 40% and 18%, respectively.	beta-ionone	47-58	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
32915344-13	2020	The BPL can reduce PET acquisition to 90 s/bed in 18F-NaF PET/CT imaging.	Fluorine-18	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
32973970-1	2020	Pyrazolyl-urea and dihydro-imidazo-pyrazolyl-urea compounds (STIRUR 13, STIRUR 41 and BUR 12) have been demonstrated to exert a strong inhibitory effect on interleukin 8 or N-formyl-methionyl-leucyl-phenylalanine-induced chemotaxis of human neutrophils.	Urea	10-14	C-X-C motif chemokine ligand 8	Homo sapiens	156-169
32973970-1	2020	Pyrazolyl-urea and dihydro-imidazo-pyrazolyl-urea compounds (STIRUR 13, STIRUR 41 and BUR 12) have been demonstrated to exert a strong inhibitory effect on interleukin 8 or N-formyl-methionyl-leucyl-phenylalanine-induced chemotaxis of human neutrophils.	Urea	45-49	C-X-C motif chemokine ligand 8	Homo sapiens	156-169
32867889-9	2020	Gender-differentiated correlations of VFA with clinical and inflammatory variables were observed in age, FeNO, immunoglobulin E, blood total white cells and neutrophils, and sputum IL-1beta and IL-8.	Fatty Acids, Volatile	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
32886659-7	2020	In CS relative to OS, there were numerous differentially expressed genes including pro-inflammatory cytokines (IL17A, IL8, IL19, IL20 and OSM) and chemokines involved in immune cell activation and recruitment (CCL20, CCL27 and CXCL6).	Cesium	3-5	C-X-C motif chemokine ligand 8	Homo sapiens	118-121
32927792-7	2020	Both formulations, however, delivered sufficient amounts of DXM to effectively suppress the production of interleukin-6 (IL-6), interleukin-8 (IL-8) and Thymic Stromal Lymphopoietin (TSLP).	Dexamethasone	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	128-141
32927792-7	2020	Both formulations, however, delivered sufficient amounts of DXM to effectively suppress the production of interleukin-6 (IL-6), interleukin-8 (IL-8) and Thymic Stromal Lymphopoietin (TSLP).	Dexamethasone	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
32669746-4	2020	In this model, indole modulates transcription factor nuclear factor kappa B (NF-kappaB) and produces the chemokine interleukin-8 (IL-8) through the activation of the aryl hydrocarbon receptor (AhR).	indole	15-21	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
32825908-0	2020	Metabolomic profiling of parapneumonic effusion reveals a regulatory role of dipeptides in interleukin-8 production in neutrophil-like cells.	Dipeptides	77-87	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
32825908-6	2020	Furthermore, with integrated proteomic and transcriptomic analyses of PPEs, the levels of dipeptides were strongly associated with the production of interleukin-8 (IL-8), an inflammation-associated cytokine.	Dipeptides	90-100	C-X-C motif chemokine ligand 8	Homo sapiens	149-162
32825908-6	2020	Furthermore, with integrated proteomic and transcriptomic analyses of PPEs, the levels of dipeptides were strongly associated with the production of interleukin-8 (IL-8), an inflammation-associated cytokine.	Dipeptides	90-100	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
32825908-7	2020	The production of IL-8 indeed increased upon the treatment of HL-60-derived neutrophilic cells with dipeptides, Gly-Val and Gly-Tyr.	Dipeptides	100-110	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
32825908-7	2020	The production of IL-8 indeed increased upon the treatment of HL-60-derived neutrophilic cells with dipeptides, Gly-Val and Gly-Tyr.	glycylvaline	112-119	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
32825908-7	2020	The production of IL-8 indeed increased upon the treatment of HL-60-derived neutrophilic cells with dipeptides, Gly-Val and Gly-Tyr.	glycyltyrosine	124-131	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
32448093-4	2020	The active mixture also reduced the production of PGE2 and IL-8 in PMA-induced A549 cells.	Tetradecanoylphorbol Acetate	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
32564453-8	2020	RESULTS: Compared to PF and PQ groups, mRNA and protein expression of IL-6, IL-8, and IL-1beta increased in samples from the BAK group in a time-dependent fashion, whereas all other cytokines showed a non-significant increase.	Benzalkonium Compounds	125-128	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
31804143-1	2020	Positron emission tomography (PET) with 18F-Sodium fluoride (18F-NaF) has emerged as a promising non-invasive imaging modality to identify high-risk and ruptured atherosclerotic plaques.	Sodium Fluoride	40-59	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
31804143-1	2020	Positron emission tomography (PET) with 18F-Sodium fluoride (18F-NaF) has emerged as a promising non-invasive imaging modality to identify high-risk and ruptured atherosclerotic plaques.	CP-18 compound	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
31804143-2	2020	By visualizing microcalcification, 18F-NaF PET holds clinical promise in refining how we evaluate coronary artery disease, shifting our focus from assessing disease burden to atherosclerosis activity.	CP-18 compound	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
31804143-3	2020	In this review we provide an overview of studies that have utilized 18F-NaF PET for imaging atherosclerosis.	CP-18 compound	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
31804143-4	2020	We discuss the associations between traditional coronary artery disease measures (risk factors) and 18F-NaF plaque activity.	CP-18 compound	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	104-107
31804143-5	2020	We also present the data on the histological validation as well as show how 18F-NaF uptake is associated with plaque morphology on intravascular and computed tomography imaging.	CP-18 compound	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	80-83
31804143-6	2020	Finally, we discuss the technical challenges associated with 18F-NaF coronary PET highlighting recent advances in this area.	CP-18 compound	61-64	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
32383139-5	2020	Moreover, CXCL8, CXCL10, CXCL11, PLSCR1, RIPK2 and USP18 were found to be potentially associated with chemo-resistance related to CAFs and prognosis of BC.	cafs	130-134	C-X-C motif chemokine ligand 8	Homo sapiens	10-15
32532788-0	2020	Plasma Interleukin-8 is a biomarker for TAK1 activation and predicts resistance to nanoliposomal irinotecan in patients with gemcitabine-refractory pancreatic cancer.	Irinotecan	97-107	C-X-C motif chemokine ligand 8	Homo sapiens	7-20
32532788-0	2020	Plasma Interleukin-8 is a biomarker for TAK1 activation and predicts resistance to nanoliposomal irinotecan in patients with gemcitabine-refractory pancreatic cancer.	gemcitabine	125-136	C-X-C motif chemokine ligand 8	Homo sapiens	7-20
32554157-15	2020	Methylprednisolone administration in six patients had no significant influence on the studied surface receptors but led to lower IL-8 and higher IL-10 plasma concentrations.	Methylprednisolone	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
32532788-12	2020	Conclusion Our study identified interleukin-8 as the most significant circulating factor for TAK1 pathway activation and candidates interleukin-8 as a potential predictive biomarker of resistance to nal-IRI in gemcitabine-refractory pancreatic cancer patients.	gemcitabine	210-221	C-X-C motif chemokine ligand 8	Homo sapiens	132-145
32921364-5	2020	Administration of fish oil resulted in lower total blood leukocyte number (P = 0.04), CRP (P = 0.013), interleukin-8 (P = 0.05) and intercellular adhesion molecule 1 (P = 0.01) concentrations, multiple organ dysfunction score, sequential organ failure assessment score (P = 0.004), early warning score (P = 0.01), and systemic inflammatory response syndrome (P = 0.03) compared to the control group.	Fish Oils	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	103-116
32293791-7	2020	In addition, NaF exposure increased the protein expression of p-ERK1/2 and decreased the protein expressions of Nrf2 and HO-1, as well as facilitated increasing ROS, 4-hydroxynonenal (4-HNE), and 8-Hydroxy-2"-deoxyguanosine (8-OHdG).	8-ohdg	196-223	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
32293791-5	2020	Moreover, pretreatment with emodin was used to shed light on the neuroprotective effects in NaF-induced toxicity in SH-SY5Y cells.	Emodin	28-34	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
32293791-7	2020	In addition, NaF exposure increased the protein expression of p-ERK1/2 and decreased the protein expressions of Nrf2 and HO-1, as well as facilitated increasing ROS, 4-hydroxynonenal (4-HNE), and 8-Hydroxy-2"-deoxyguanosine (8-OHdG).	ros	161-164	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
32293791-7	2020	In addition, NaF exposure increased the protein expression of p-ERK1/2 and decreased the protein expressions of Nrf2 and HO-1, as well as facilitated increasing ROS, 4-hydroxynonenal (4-HNE), and 8-Hydroxy-2"-deoxyguanosine (8-OHdG).	8-ohdg	225-231	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
32293791-7	2020	In addition, NaF exposure increased the protein expression of p-ERK1/2 and decreased the protein expressions of Nrf2 and HO-1, as well as facilitated increasing ROS, 4-hydroxynonenal (4-HNE), and 8-Hydroxy-2"-deoxyguanosine (8-OHdG).	4-hydroxy-2-nonenal	166-182	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
32293791-7	2020	In addition, NaF exposure increased the protein expression of p-ERK1/2 and decreased the protein expressions of Nrf2 and HO-1, as well as facilitated increasing ROS, 4-hydroxynonenal (4-HNE), and 8-Hydroxy-2"-deoxyguanosine (8-OHdG).	4-hydroxy-2-nonenal	184-189	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
32293791-8	2020	Pretreatment with emodin significantly recovered these alterations caused by NaF.	Emodin	18-24	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
32515014-13	2020	The expression of IL-8 gene was high for all materials, ProRoot MTA caused significant overexpression, and the addition of RSV reduced the expression of IL-8 in the Calcimol LC, TheraCal LC and ProRoot MTA groups and led to increased expression of IL-10 in the Calcimol LC, Life and Biodentine groups.	Resveratrol	123-126	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
32964957-12	2020	Moreover, relative levels of IL-6, IL-8, TNF-alpha, and MMP3/9/13 were significantly suppressed by SF1670 stimuli compared with IL-1beta group.	SF1670	99-105	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
32717131-0	2020	Interleukin-8 drives CD38 to form NAADP from NADP+ and NAAD in the endolysosomes to mobilize Ca2+ and effect cell migration.	NAADP	34-39	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
32717131-0	2020	Interleukin-8 drives CD38 to form NAADP from NADP+ and NAAD in the endolysosomes to mobilize Ca2+ and effect cell migration.	NADP	45-50	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
32717131-3	2020	We discovered that CD38 catalyzes synthesis of NAADP by exchanging the nicotinamide moiety of nicotinamide adenine dinucleotide phosphate (NADP+ ) for the NA group of nicotinic acid adenine dinucleotide (NAAD) inside endolysosomes of interleukin 8 (IL8)-treated lymphokine-activated killer (LAK) cells.	NAADP	47-52	C-X-C motif chemokine ligand 8	Homo sapiens	234-247
32717131-3	2020	We discovered that CD38 catalyzes synthesis of NAADP by exchanging the nicotinamide moiety of nicotinamide adenine dinucleotide phosphate (NADP+ ) for the NA group of nicotinic acid adenine dinucleotide (NAAD) inside endolysosomes of interleukin 8 (IL8)-treated lymphokine-activated killer (LAK) cells.	NAADP	47-52	C-X-C motif chemokine ligand 8	Homo sapiens	249-252
32717131-3	2020	We discovered that CD38 catalyzes synthesis of NAADP by exchanging the nicotinamide moiety of nicotinamide adenine dinucleotide phosphate (NADP+ ) for the NA group of nicotinic acid adenine dinucleotide (NAAD) inside endolysosomes of interleukin 8 (IL8)-treated lymphokine-activated killer (LAK) cells.	Niacinamide	71-83	C-X-C motif chemokine ligand 8	Homo sapiens	234-247
32717131-3	2020	We discovered that CD38 catalyzes synthesis of NAADP by exchanging the nicotinamide moiety of nicotinamide adenine dinucleotide phosphate (NADP+ ) for the NA group of nicotinic acid adenine dinucleotide (NAAD) inside endolysosomes of interleukin 8 (IL8)-treated lymphokine-activated killer (LAK) cells.	Niacinamide	71-83	C-X-C motif chemokine ligand 8	Homo sapiens	249-252
32717131-3	2020	We discovered that CD38 catalyzes synthesis of NAADP by exchanging the nicotinamide moiety of nicotinamide adenine dinucleotide phosphate (NADP+ ) for the NA group of nicotinic acid adenine dinucleotide (NAAD) inside endolysosomes of interleukin 8 (IL8)-treated lymphokine-activated killer (LAK) cells.	NADP	94-137	C-X-C motif chemokine ligand 8	Homo sapiens	234-247
32717131-3	2020	We discovered that CD38 catalyzes synthesis of NAADP by exchanging the nicotinamide moiety of nicotinamide adenine dinucleotide phosphate (NADP+ ) for the NA group of nicotinic acid adenine dinucleotide (NAAD) inside endolysosomes of interleukin 8 (IL8)-treated lymphokine-activated killer (LAK) cells.	NADP	94-137	C-X-C motif chemokine ligand 8	Homo sapiens	249-252
32717131-3	2020	We discovered that CD38 catalyzes synthesis of NAADP by exchanging the nicotinamide moiety of nicotinamide adenine dinucleotide phosphate (NADP+ ) for the NA group of nicotinic acid adenine dinucleotide (NAAD) inside endolysosomes of interleukin 8 (IL8)-treated lymphokine-activated killer (LAK) cells.	NADP	139-144	C-X-C motif chemokine ligand 8	Homo sapiens	234-247
32717131-3	2020	We discovered that CD38 catalyzes synthesis of NAADP by exchanging the nicotinamide moiety of nicotinamide adenine dinucleotide phosphate (NADP+ ) for the NA group of nicotinic acid adenine dinucleotide (NAAD) inside endolysosomes of interleukin 8 (IL8)-treated lymphokine-activated killer (LAK) cells.	NADP	139-144	C-X-C motif chemokine ligand 8	Homo sapiens	249-252
32717131-3	2020	We discovered that CD38 catalyzes synthesis of NAADP by exchanging the nicotinamide moiety of nicotinamide adenine dinucleotide phosphate (NADP+ ) for the NA group of nicotinic acid adenine dinucleotide (NAAD) inside endolysosomes of interleukin 8 (IL8)-treated lymphokine-activated killer (LAK) cells.	nicotinic acid adenine dinucleotide	167-202	C-X-C motif chemokine ligand 8	Homo sapiens	234-247
32717131-3	2020	We discovered that CD38 catalyzes synthesis of NAADP by exchanging the nicotinamide moiety of nicotinamide adenine dinucleotide phosphate (NADP+ ) for the NA group of nicotinic acid adenine dinucleotide (NAAD) inside endolysosomes of interleukin 8 (IL8)-treated lymphokine-activated killer (LAK) cells.	nicotinic acid adenine dinucleotide	167-202	C-X-C motif chemokine ligand 8	Homo sapiens	249-252
32717131-3	2020	We discovered that CD38 catalyzes synthesis of NAADP by exchanging the nicotinamide moiety of nicotinamide adenine dinucleotide phosphate (NADP+ ) for the NA group of nicotinic acid adenine dinucleotide (NAAD) inside endolysosomes of interleukin 8 (IL8)-treated lymphokine-activated killer (LAK) cells.	nicotinic acid adenine dinucleotide	47-51	C-X-C motif chemokine ligand 8	Homo sapiens	234-247
32717131-3	2020	We discovered that CD38 catalyzes synthesis of NAADP by exchanging the nicotinamide moiety of nicotinamide adenine dinucleotide phosphate (NADP+ ) for the NA group of nicotinic acid adenine dinucleotide (NAAD) inside endolysosomes of interleukin 8 (IL8)-treated lymphokine-activated killer (LAK) cells.	nicotinic acid adenine dinucleotide	47-51	C-X-C motif chemokine ligand 8	Homo sapiens	249-252
32717131-4	2020	Upon IL8 stimulation, cytosolic NADP+ is transported to acidified endolysosomes via connexin 43 (Cx43) and gated by cAMP-EPAC-RAP1-PP2A signaling.	NADP	32-37	C-X-C motif chemokine ligand 8	Homo sapiens	5-8
32717131-4	2020	Upon IL8 stimulation, cytosolic NADP+ is transported to acidified endolysosomes via connexin 43 (Cx43) and gated by cAMP-EPAC-RAP1-PP2A signaling.	Cyclic AMP	116-120	C-X-C motif chemokine ligand 8	Homo sapiens	5-8
32962811-4	2020	The expression of four key genes involved in inflammation and apoptosis including IL-8, IL-1beta, IL-10 and Bcl2 depicted that the MTX-SA had controversial behavior in different doses on the inflammatory transcription.	mtx-sa	131-137	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
32645629-7	2020	We found that DMF significantly improved cell viability and reduced the expression of pro-inflammatory cytokines and chemokines, including IL-6, IL-8, and MCP-1.	Dimethyl Fumarate	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
32515014-13	2020	The expression of IL-8 gene was high for all materials, ProRoot MTA caused significant overexpression, and the addition of RSV reduced the expression of IL-8 in the Calcimol LC, TheraCal LC and ProRoot MTA groups and led to increased expression of IL-10 in the Calcimol LC, Life and Biodentine groups.	Resveratrol	123-126	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
32726647-4	2020	OxLDL priming induced a proinflammatory memory with increased production of inflammatory cytokines such as IL-6, IL-8 and MCP-1 in response to PAM3cys4 restimulation.	pam3cys4	143-151	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
32729244-3	2020	In this randomized, placebo-controlled trial, we aimed to evaluate the potential reflection of short-term xylitol consumption on pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-8) and S. mutans counts by ELISA and qPCR (Quantitative real-time PCR), respectively.	Xylitol	106-113	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
33181840-11	2020	CONCLUSION(S): The CFDs containing NaF only have higher concentrations of bioavailable fluoride.	Fluorides	87-95	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
32945158-9	2020	Histamine is involved in the expression of chemokine IL-8 and cytokine IL-6, an effect that can be inhibited by histamine receptor antagonists.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
32945158-9	2020	Histamine is involved in the expression of chemokine IL-8 and cytokine IL-6, an effect that can be inhibited by histamine receptor antagonists.	Histamine	112-121	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
32387042-7	2020	However, in CF macrophages lenabasum downregulated macrophage polarization into the pro-inflammatory M1 phenotype and secretion of the pro-inflammatory cytokines IL-8 and TNF-alpha in a dose-dependent manner.	lenabasum	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
32015430-6	2020	Mono-n-butyl phthalate (MBP) was correlated with higher IL-1beta, IL-6, and CRP expression in placentae of male fetuses and with higher IL-6, CRP, MCP-1, IL-8, IL-10, and CD68 expression in placentae of female fetuses.	monobutyl phthalate	0-22	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
32015430-6	2020	Mono-n-butyl phthalate (MBP) was correlated with higher IL-1beta, IL-6, and CRP expression in placentae of male fetuses and with higher IL-6, CRP, MCP-1, IL-8, IL-10, and CD68 expression in placentae of female fetuses.	monobutyl phthalate	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
32780615-2	2020	CXCL8 harbors 2 disulfide bonds for its stability.	Disulfides	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
32534879-1	2020	In this work, a multifunctional hierarchical nanoformulation composed of biodegradable chitosan (CS) coated poly (lactic-co-glycolic acid) (PLGA) nanocarriers loaded with docetaxel (Doc) and interleukin-8 (IL-8) small interfering RNA (siRNA) electrostatically bound to upconversion nanoparticles (UCNPs), is developed to treat castration-resistant prostate cancer (CRPC).	Chitosan	97-99	C-X-C motif chemokine ligand 8	Homo sapiens	191-204
32534879-1	2020	In this work, a multifunctional hierarchical nanoformulation composed of biodegradable chitosan (CS) coated poly (lactic-co-glycolic acid) (PLGA) nanocarriers loaded with docetaxel (Doc) and interleukin-8 (IL-8) small interfering RNA (siRNA) electrostatically bound to upconversion nanoparticles (UCNPs), is developed to treat castration-resistant prostate cancer (CRPC).	Chitosan	97-99	C-X-C motif chemokine ligand 8	Homo sapiens	206-210
31907823-8	2020	RESULTS: The results showed that AS-IV significantly reduced the levels of ROS, LDH, MDA, IL-8, IL-1beta, and IL-6, and increased the level of SOD in intermittent hypoxia-induced Beas-2B cells.	astragaloside A	33-38	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
32249518-8	2020	Carvacrol had a positive effect on the reduction of interleukin (IL)-1beta, IL-4, IL-8 and malondialdehyde (MDA); however, the analysis indicated that carvacrol had no effect on IL-6 and tumor necrosis factor alpha (TNF-alpha), probably due to the methodological quality of the studies and their heterogeneity.	carvacrol	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
32542667-7	2020	The effect of a combination with two natural compounds, oleanolic acid (OA) and ursolic acid (UA), was evaluated on the expression of the IL-8 axis and epithelial cell growth.	Oleanolic Acid	56-70	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
32542667-7	2020	The effect of a combination with two natural compounds, oleanolic acid (OA) and ursolic acid (UA), was evaluated on the expression of the IL-8 axis and epithelial cell growth.	Oleanolic Acid	72-74	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
32542667-7	2020	The effect of a combination with two natural compounds, oleanolic acid (OA) and ursolic acid (UA), was evaluated on the expression of the IL-8 axis and epithelial cell growth.	ursolic acid	80-92	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
32542667-7	2020	The effect of a combination with two natural compounds, oleanolic acid (OA) and ursolic acid (UA), was evaluated on the expression of the IL-8 axis and epithelial cell growth.	ursolic acid	94-96	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
32198119-4	2020	PURPOSE: To examine fluorine-18 sodium fluoride (18F-NaF) PET/computed tomography (PET/CT) findings in patients with inflammatory low back pain and evaluate the utility of this modality in the diagnosis of ankylosing spondylitis (AS) according to the Assessment of SpondyloArthritis International Society (ASAS) criteria.	fluorine-18 sodium fluoride	20-47	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
32198119-14	2020	CONCLUSION: 18F-NaF PET/CT yielded significantly different findings between the two groups according to the ASAS criteria and is useful for diagnosing AS.	asas	108-112	C-X-C motif chemokine ligand 8	Homo sapiens	16-19
33629550-8	2020	Conclusion: 100 mug/ml Nano-SiO2 combined with 31C cold exposure can synergistically reduce the activity of A549 cells and increase the expression level of inflammatory factors IL-6 and IL-8 .	Silicon Dioxide	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
32859169-6	2020	RESULTS: In non-DS patients, IL-8 plasma levels were significantly reduced in the seventh day of ATRA treatment (34.16; 6.99 to 147.11 pg mL- 1 in D0 vs. 10.9; 0 to 26.81 pg mL- 1 in D7; p = 0.02) whereas their levels did not discriminate between DS and non-DS development during the entire induction period (all p > 0.05 in D0, D3, and D7).	Tretinoin	97-101	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
32929393-2	2020	18F-sodium fluoride (18F-NaF) is a sensitive PET radiotracer for detection of abnormal bone metabolism and, therefore, is particularly suited to assess the degree of bone involvement in MM patients.	18f-sodium fluoride	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
32786371-1	2021	Calcium minerals such as hydroxyapatite (HAp) can be detected non-invasively in vivo using nuclear imaging agents such as [18F]NaF (available from cyclotrons), for positron emission tomography (PET) and 99mTc-radiolabelled bisphosphonates (BP; available from 99mTc generators for single photon emission computed tomography (SPECT) or scintigraphy).	Calcium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	127-130
32786371-1	2021	Calcium minerals such as hydroxyapatite (HAp) can be detected non-invasively in vivo using nuclear imaging agents such as [18F]NaF (available from cyclotrons), for positron emission tomography (PET) and 99mTc-radiolabelled bisphosphonates (BP; available from 99mTc generators for single photon emission computed tomography (SPECT) or scintigraphy).	Durapatite	25-39	C-X-C motif chemokine ligand 8	Homo sapiens	127-130
32786865-5	2020	Cytokines IL-8 and IL-6, production was significantly reduced by 40% and 51%, respectively with 1 mM pre-treatment of gamma-EV.	gamma-ev	118-126	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
32641497-3	2020	Herein, we demonstrate that 2-12(S)-HETE-lysophospholipids as well as non-esterified 12(S)-HETE are potent lipid mediators that activate THP-1 human monocytic cells to generate tumor necrosis factor alpha (TNFalpha) and interleukin 8 (IL8).	2-12(s)-hete-lysophospholipids	28-58	C-X-C motif chemokine ligand 8	Homo sapiens	220-233
32974315-13	2020	In all scenarios, among the tested mediators the most pronounced anti-inflammatory effect of MP was observed for IL-8.	Methylprednisolone	93-95	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
32641497-3	2020	Herein, we demonstrate that 2-12(S)-HETE-lysophospholipids as well as non-esterified 12(S)-HETE are potent lipid mediators that activate THP-1 human monocytic cells to generate tumor necrosis factor alpha (TNFalpha) and interleukin 8 (IL8).	2-12(s)-hete-lysophospholipids	28-58	C-X-C motif chemokine ligand 8	Homo sapiens	235-238
32641497-3	2020	Herein, we demonstrate that 2-12(S)-HETE-lysophospholipids as well as non-esterified 12(S)-HETE are potent lipid mediators that activate THP-1 human monocytic cells to generate tumor necrosis factor alpha (TNFalpha) and interleukin 8 (IL8).	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	220-233
32641497-3	2020	Herein, we demonstrate that 2-12(S)-HETE-lysophospholipids as well as non-esterified 12(S)-HETE are potent lipid mediators that activate THP-1 human monocytic cells to generate tumor necrosis factor alpha (TNFalpha) and interleukin 8 (IL8).	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	235-238
32923106-11	2020	CONCLUSION: There was a positive correlation between TG/HDL ratio with global cardiac microcalcification assessed by NaF-PET/CT imaging.	Triglycerides	53-55	C-X-C motif chemokine ligand 8	Homo sapiens	117-120
32814567-8	2020	Chitin surface was used to develop a sandwich ELISA to detect the chimeric human protein c-myc-GST-IL8 cloned and expressed in Escherichia coli.	Chitin	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
32827640-14	2020	The capacity of PM10 to promote pro-inflammatory cytokines such as IL-8 and IL-23, likely to promote a Th2 profile, suggests these effects might be linked to worsening of chronic respiratory disease as these mediators are linked to asthma.	pm10	16-20	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
32827640-14	2020	The capacity of PM10 to promote pro-inflammatory cytokines such as IL-8 and IL-23, likely to promote a Th2 profile, suggests these effects might be linked to worsening of chronic respiratory disease as these mediators are linked to asthma.	th2	103-106	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
32512068-4	2020	TAMs in IBC secrete high levels of the cytokines interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1/CCL2) compared to non-IBC patients.	tams	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	49-62
32913546-0	2020	Nintedanib ameliorates tracheal stenosis by activating HDAC2 and suppressing IL-8 and VEGF in rabbit.	nintedanib	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
32913546-10	2020	The mRNA of HDAC2 was increased and that of IL-8 and VEGF was decreased significantly in the tracheal tissue following nintedanib treatment.	nintedanib	119-129	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
32913546-12	2020	Budesonide treatment also resulted in increased HDAC2 expression and decreased IL-8 and VEGF expression.	Budesonide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
32913546-15	2020	Therefore, it is concluded that nintedanib alleviates the acquired tracheal stenosis by activating HDAC2 expression and suppressing IL-8 and VEGF expression, and may offer new option to medical treatment for the disease.	nintedanib	32-42	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
32512068-4	2020	TAMs in IBC secrete high levels of the cytokines interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1/CCL2) compared to non-IBC patients.	tams	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
32512068-8	2020	Dasatinib, an inhibitor of p-Src, and U0126, an inhibitor of p-Erk1/2, down-regulated invasion and expression of CTSB by HCC70 and SUM149 cells, a mechanism that is reversed by IL-8 and MCP-1/CCL2.	Dasatinib	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
32512068-8	2020	Dasatinib, an inhibitor of p-Src, and U0126, an inhibitor of p-Erk1/2, down-regulated invasion and expression of CTSB by HCC70 and SUM149 cells, a mechanism that is reversed by IL-8 and MCP-1/CCL2.	U 0126	38-43	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
32691597-0	2020	Synthesis of Acyl Fluorides from Carboxylic Acids Using NaF-Assisted Deoxofluorination with XtalFluor-E.	deoxofluorination	69-86	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
32633119-0	2020	NaF/RbF treated Cu(In,Ga)Se2 thin-film solar cell absorbers: Distinct surface modifications caused by two different types of Rubidium chemistry.	Copper	16-18	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
32691597-0	2020	Synthesis of Acyl Fluorides from Carboxylic Acids Using NaF-Assisted Deoxofluorination with XtalFluor-E.	diethylaminodifluorosulfinium tetrafluoroborate	92-103	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
32691597-2	2020	This transformation, assisted by a catalytic amount of NaF, occurs at room temperature in EtOAc, where XtalFluor-E behaves as the activating agent and the fluoride source.	diethylaminodifluorosulfinium tetrafluoroborate	103-114	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
32691597-2	2020	This transformation, assisted by a catalytic amount of NaF, occurs at room temperature in EtOAc, where XtalFluor-E behaves as the activating agent and the fluoride source.	Fluorides	155-163	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
32691597-0	2020	Synthesis of Acyl Fluorides from Carboxylic Acids Using NaF-Assisted Deoxofluorination with XtalFluor-E.	acyl fluorides	13-27	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
32691597-0	2020	Synthesis of Acyl Fluorides from Carboxylic Acids Using NaF-Assisted Deoxofluorination with XtalFluor-E.	Carboxylic Acids	33-49	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
32633119-0	2020	NaF/RbF treated Cu(In,Ga)Se2 thin-film solar cell absorbers: Distinct surface modifications caused by two different types of Rubidium chemistry.	Rubidium	125-133	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
32633119-3	2020	The already Cu deficient surface region after NaF PDT, which is modeled as a Cu:(In+Ga):Se = 1:5:8 phase, shows further depletion after NaF/RbF PDT and seems to incorporate some Rb.	Copper	12-14	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
32633119-3	2020	The already Cu deficient surface region after NaF PDT, which is modeled as a Cu:(In+Ga):Se = 1:5:8 phase, shows further depletion after NaF/RbF PDT and seems to incorporate some Rb.	Copper	12-14	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
32633119-3	2020	The already Cu deficient surface region after NaF PDT, which is modeled as a Cu:(In+Ga):Se = 1:5:8 phase, shows further depletion after NaF/RbF PDT and seems to incorporate some Rb.	Copper	77-79	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
32633119-3	2020	The already Cu deficient surface region after NaF PDT, which is modeled as a Cu:(In+Ga):Se = 1:5:8 phase, shows further depletion after NaF/RbF PDT and seems to incorporate some Rb.	Rubidium	140-142	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
32633119-4	2020	Additionally, we have found strong indications for the NaF/RbF PDT induced formation of a Rb-In-Se-type compound with a 1:1:2 stoichiometry partially covering the absorber surface.	rb-in	90-95	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
32543782-8	2020	RESULTS: The release of IL-8 was significantly increased after exposure to TEGDMA, Bis-GMA, UDMA, or TEGDMA in combination with Bis-GMA or UDMA compared to the unstimulated controls.	triethylene glycol dimethacrylate	75-81	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
32691592-1	2020	NaMoO3F and Na5W3O9F5 were synthesized by solvothermal reaction of MoO3 and WO3, respectively, with NaF in nonaqueous solvents.	namoo3f	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
32691592-1	2020	NaMoO3F and Na5W3O9F5 were synthesized by solvothermal reaction of MoO3 and WO3, respectively, with NaF in nonaqueous solvents.	na5w3o9f5	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
32691592-1	2020	NaMoO3F and Na5W3O9F5 were synthesized by solvothermal reaction of MoO3 and WO3, respectively, with NaF in nonaqueous solvents.	molybdenum trioxide	2-6	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
32691592-1	2020	NaMoO3F and Na5W3O9F5 were synthesized by solvothermal reaction of MoO3 and WO3, respectively, with NaF in nonaqueous solvents.	wo3	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
32691592-4	2020	In the case of the reaction of MoO3 with NaF, the kind of solvent largely affected the obtained morphologies of NaMoO3F.	molybdenum trioxide	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
32691592-4	2020	In the case of the reaction of MoO3 with NaF, the kind of solvent largely affected the obtained morphologies of NaMoO3F.	namoo3f	112-119	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
32691592-6	2020	In addition, the solvothermal reaction of WO3 with NaF led to the formation of Na5W3O9F5.	wo3	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
32691592-6	2020	In addition, the solvothermal reaction of WO3 with NaF led to the formation of Na5W3O9F5.	na5w3o9f5	79-88	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
32691592-8	2020	The effect of the solvents on the morphologies of the obtained oxyfluorides probably resulted from the difference of the solubility of NaF and the subsequent dissolution ratio of MoO3 or WO3 in the used solvents.	fluorine monoxide	63-75	C-X-C motif chemokine ligand 8	Homo sapiens	135-138
32785678-8	2020	Results: Trehalose reduced the proinflammatory mediators TNF-alpha, IL-1beta, IL-6, and IL-8 in primary HCECs at 450 mOsM.	Trehalose	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
32335896-5	2020	KEY RESULTS: Impaired inhibition of IL-8 production by dexamethasone was detected in PBMCs from COPD patients and in CSE-exposed U937 cells, together with reduced levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and histone deacetylase-2 (HDAC2).	Dexamethasone	55-68	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
32335896-6	2020	In both PBMCs and CSE-exposed U937 cells, andrographolide restored dexamethasone inhibition of IL-8 production, accompanied by the up-regulation of Nrf2 and HDAC2 levels.	andrographolide	42-57	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
32335896-6	2020	In both PBMCs and CSE-exposed U937 cells, andrographolide restored dexamethasone inhibition of IL-8 production, accompanied by the up-regulation of Nrf2 and HDAC2 levels.	Dexamethasone	67-80	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
32464779-4	2020	Urinary metabolites of PAHs (i.e., OH-PAHs), measured as indicators of total PAH exposure, showed significant associations with markers of respiratory and systemic inflammation, including exhaled nitric oxide, interleukin (IL)-6 in exhaled breath condensate, and blood IL-2 and IL-8 levels and leucocyte count.	oh-pahs	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	278-282
32464779-4	2020	Urinary metabolites of PAHs (i.e., OH-PAHs), measured as indicators of total PAH exposure, showed significant associations with markers of respiratory and systemic inflammation, including exhaled nitric oxide, interleukin (IL)-6 in exhaled breath condensate, and blood IL-2 and IL-8 levels and leucocyte count.	Polycyclic Aromatic Hydrocarbons	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	278-282
32299619-1	2020	AIM: To analyse the relationship between 18F-labelled sodium fluoride (NaF) uptake and lumbar back pain in patients with lumbosacral transitional vertebra (LSTV) a congenital malformation of the lumbosacral spine.	Sodium Fluoride	54-69	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
32543782-8	2020	RESULTS: The release of IL-8 was significantly increased after exposure to TEGDMA, Bis-GMA, UDMA, or TEGDMA in combination with Bis-GMA or UDMA compared to the unstimulated controls.	Bisphenol A-Glycidyl Methacrylate	83-90	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
32299619-8	2020	The sensitivity and specificity of 18F-NaF uptake at LSTV as a cause of pain were 82% (95% confidence interval [CI]: 65-93%) and 86% (95% CI: 64-97%).	lstv	53-57	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
32299619-10	2020	CONCLUSIONS: 18F-NaF PET/CT can be useful in evaluating back pain and 18F-NaF may be used as an adjunctive biological maker for assessing LSTV as a potential cause of pain.	lstv	138-142	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
32543782-8	2020	RESULTS: The release of IL-8 was significantly increased after exposure to TEGDMA, Bis-GMA, UDMA, or TEGDMA in combination with Bis-GMA or UDMA compared to the unstimulated controls.	urethane dimethacrylate luting resin	92-96	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
32543782-8	2020	RESULTS: The release of IL-8 was significantly increased after exposure to TEGDMA, Bis-GMA, UDMA, or TEGDMA in combination with Bis-GMA or UDMA compared to the unstimulated controls.	triethylene glycol dimethacrylate	101-107	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
32543782-8	2020	RESULTS: The release of IL-8 was significantly increased after exposure to TEGDMA, Bis-GMA, UDMA, or TEGDMA in combination with Bis-GMA or UDMA compared to the unstimulated controls.	urethane dimethacrylate luting resin	139-143	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
32543782-11	2020	CONCLUSION: The combination of TEGDMA and Bis-GMA had a synergistic proinflammatory effect on neutrophils by increasing the release of IL-8 and the formation of NET structures.	triethylene glycol dimethacrylate	31-37	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
32543782-11	2020	CONCLUSION: The combination of TEGDMA and Bis-GMA had a synergistic proinflammatory effect on neutrophils by increasing the release of IL-8 and the formation of NET structures.	Bisphenol A-Glycidyl Methacrylate	42-49	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
32342245-1	2020	18F-sodium fluoride (18F-NaF) has been used to access aortic stenosis in clinical research setting.	18f-sodium fluoride	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
32445015-12	2020	A significant increase in activation of NF-kappaB and production of pro-inflammatory cytokines IL-6 and IL-8 was observed after treatment with 4-HNE.	4-hydroxy-2-nonenal	143-148	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
31667675-2	2020	We sought to address this limitation by utilizing the distinctively high bone uptake rate constant Ki expected from 18F-Sodium Fluoride (18F-NaF) to segment bones from PET data and support 5-class hybrid PET/MR-driven AC for 18F-NaF and 18F-Fluorodeoxyglucose (18F-FDG) PET/MR cardiovascular imaging.	Sodium Fluoride	116-135	C-X-C motif chemokine ligand 8	Homo sapiens	141-144
32534189-4	2020	In vitro studies have demonstrated the capacity of azithromycin in reducing production of pro-inflammatory cytokines such as IL-8, IL-6, TNF alpha, reduce oxidative stress, and modulate T-helper functions.	Azithromycin	51-63	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
32588186-10	2020	Namely, butyrate ameliorated the overproduction of adhesion molecules, including VCAM-1 and E-selectin, reduced oxidative stress by reducing the levels of ROS and 4-HNE, and suppressed inflammation via inhibition of MCP-1 and IL-8.	Butyrates	8-16	C-X-C motif chemokine ligand 8	Homo sapiens	226-230
32428523-1	2020	OBJECTIVES: The study aimed to compare the effectiveness of 38% silver diamine fluoride (SDF) solution, and 5% sodium fluoride (NaF) varnish applied semiannually in arresting dentin caries in young children with high caries risk.	Sodium Fluoride	111-126	C-X-C motif chemokine ligand 8	Homo sapiens	128-131
32531710-7	2020	C-BF and NFN treatment decreased (P < 0.05) IL-6, IL-8, IL-22, IL-10 and transforming growth factor-beta (TGF-beta) production in the jejunum and ileum compared with the control group.	nfn	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
32752252-6	2020	Aesculetin inhibited alveolar epithelial induction of the mesenchymal markers in mCM-exposed/IL-8-loaded A549 cells ( 47-51% inhibition), while epithelial markers were induced in aesculetin-treated cells subject to mCM/IL-8 ( 1.5-2.3-fold induction).	esculetin	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
32382745-11	2020	NaF-EDTA plasma T Cavg for oral TU group was 403 +- 128 ng/dL (~14 +- 4 nmol/L; mean +- SD) [serum T equivalent ~ 489 +- 155 ng/dL (17 +- 5 nmol/L)] and for topical T was 391 +- 140 ng/dL (~14 +- 5 nmol/L).	Edetic Acid	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
31667675-2	2020	We sought to address this limitation by utilizing the distinctively high bone uptake rate constant Ki expected from 18F-Sodium Fluoride (18F-NaF) to segment bones from PET data and support 5-class hybrid PET/MR-driven AC for 18F-NaF and 18F-Fluorodeoxyglucose (18F-FDG) PET/MR cardiovascular imaging.	Fluorodeoxyglucose F18	237-259	C-X-C motif chemokine ligand 8	Homo sapiens	141-144
31667675-2	2020	We sought to address this limitation by utilizing the distinctively high bone uptake rate constant Ki expected from 18F-Sodium Fluoride (18F-NaF) to segment bones from PET data and support 5-class hybrid PET/MR-driven AC for 18F-NaF and 18F-Fluorodeoxyglucose (18F-FDG) PET/MR cardiovascular imaging.	Fluorodeoxyglucose F18	261-268	C-X-C motif chemokine ligand 8	Homo sapiens	141-144
31667675-9	2020	In the R4:1 human cohort, the mean 18F-FDG:18F-NaF TBR increased by 12.2% at carotid bifurcations wall and 19.9% at vertebral bones.	Fluorodeoxyglucose F18	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
32627003-0	2020	Molecular mechanism of gossypol mediating CCL2 and IL-8 attenuation in triple-negative breast cancer cells.	Gossypol	23-31	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
33149453-3	2020	Hence, the aim and objective of the study was to assess and compare the root caries remineralization effect of plain milk, 5ppm of fluoridated milk, and 5ppm of NaF in deionized water.	Water	178-183	C-X-C motif chemokine ligand 8	Homo sapiens	161-164
32487373-1	2020	In this study, we report the silver molybdate nanoparticles (beta-Ag2MoO4 NPs) based non-invasive and sensitive electrochemical immunosensor for label-free detection of Interleukin-8 (IL-8) biomarker.	beta-ag2moo4	61-73	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
32487373-0	2020	Silver molybdate nanoparticles based immunosensor for the non-invasive detection of Interleukin-8 biomarker.	Silver molybdate	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
32487373-1	2020	In this study, we report the silver molybdate nanoparticles (beta-Ag2MoO4 NPs) based non-invasive and sensitive electrochemical immunosensor for label-free detection of Interleukin-8 (IL-8) biomarker.	Silver molybdate	29-45	C-X-C motif chemokine ligand 8	Homo sapiens	169-182
32487373-1	2020	In this study, we report the silver molybdate nanoparticles (beta-Ag2MoO4 NPs) based non-invasive and sensitive electrochemical immunosensor for label-free detection of Interleukin-8 (IL-8) biomarker.	Silver molybdate	29-45	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
32487373-1	2020	In this study, we report the silver molybdate nanoparticles (beta-Ag2MoO4 NPs) based non-invasive and sensitive electrochemical immunosensor for label-free detection of Interleukin-8 (IL-8) biomarker.	beta-ag2moo4	61-73	C-X-C motif chemokine ligand 8	Homo sapiens	169-182
31945773-9	2020	This molecule is developmentally functional in immature but not mature intestinal enterocytes; ILA reduces the interleukin-8 (IL-8) response after IL-1beta stimulus.	indole-3-lactic acid	95-98	C-X-C motif chemokine ligand 8	Homo sapiens	111-124
32311229-5	2020	Here, we examined the interaction between Ef.LTA and Pg.LPS on IL-8 induction in human periodontal ligament (PDL) cells.	Leukotriene A4	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
32311229-5	2020	Here, we examined the interaction between Ef.LTA and Pg.LPS on IL-8 induction in human periodontal ligament (PDL) cells.	pg	53-55	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
32311229-6	2020	Pg.LPS, but not Ef.LTA, induced IL-8 expression at both mRNA and protein levels, which was suppressed in the presence of Ef.LTA.	pg	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
32311229-9	2020	Furthermore, Ef.LTA suppressed Pg.LPS-induced IL-8 promoter activity as well as AP-1, NF-IL6 and NF-kappaB transcription factors, which are indispensable for IL-8 expression.	Leukotriene A4	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
32311229-9	2020	Furthermore, Ef.LTA suppressed Pg.LPS-induced IL-8 promoter activity as well as AP-1, NF-IL6 and NF-kappaB transcription factors, which are indispensable for IL-8 expression.	Leukotriene A4	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
32311229-9	2020	Furthermore, Ef.LTA suppressed Pg.LPS-induced IL-8 promoter activity as well as AP-1, NF-IL6 and NF-kappaB transcription factors, which are indispensable for IL-8 expression.	pg	31-33	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
32311229-9	2020	Furthermore, Ef.LTA suppressed Pg.LPS-induced IL-8 promoter activity as well as AP-1, NF-IL6 and NF-kappaB transcription factors, which are indispensable for IL-8 expression.	pg	31-33	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
32311229-11	2020	In addition, silencing IRAK-M restored the decreased IL-8 expression by Ef.LTA in the presence of Pg.LPS.	Leukotriene A4	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
32311229-11	2020	In addition, silencing IRAK-M restored the decreased IL-8 expression by Ef.LTA in the presence of Pg.LPS.	pg	98-100	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
32311229-12	2020	Collectively, these results suggest that Ef.LTA inhibits Pg.LPS-induced IL-8 expression in human PDL cells via inducing the expression of a negative regulator of TLR signaling cascades, IRAK-M.	pg	57-59	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
31945773-9	2020	This molecule is developmentally functional in immature but not mature intestinal enterocytes; ILA reduces the interleukin-8 (IL-8) response after IL-1beta stimulus.	indole-3-lactic acid	95-98	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
32848840-12	2020	Inhibition of CFTR, significantly increased intracellular ROS and H2O2 levels over 30 min and significantly decreased Nrf2 expression by 70% while increasing SOD-2 expression over 24 h. CFTR siRNA significantly increased constitutive expression of IL-8 by HLMVECs.	Hydrogen Peroxide	66-70	C-X-C motif chemokine ligand 8	Homo sapiens	248-252
32802081-12	2020	Atenolol increased IL-1RA in stroke-Mo and decreased IL-8 secretion from MSCs indicating an anti-inflammatory effect of atenolol on secretomes of these cells.	Atenolol	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
32802081-13	2020	Captopril increased IL-8 from stroke-Mo and increased IL-6, IL-8, and MCP-1 secretions from MSCs.	Captopril	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
32802081-13	2020	Captopril increased IL-8 from stroke-Mo and increased IL-6, IL-8, and MCP-1 secretions from MSCs.	Captopril	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
32802081-15	2020	Atenolol increased the secretion of IL-8 and MCP-1 while captopril increased the secretion of IL-6 and MCP-1 from MSCs.	Atenolol	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
32802081-17	2020	Losartan reduced MCP-1 and TNF-alpha from stroke-Mo and reduced IL-8 from cocultures of stroke-Mo and MSCs.	Losartan	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
32727400-12	2020	Gene expression of the tumor-promoting cytokines and mediators, such as transforming growth factor (TGF)-beta1, vascular endothelial growth factor (VEGF), interleukin (IL)-8, and IL-6 were significantly suppressed by statins and zoledronic acid by up to 90% (p < 0.001).	Zoledronic Acid	229-244	C-X-C motif chemokine ligand 8	Homo sapiens	155-173
32848840-15	2020	The effects of TNF-alpha and GlyH-101 on IL-8 expression were additive and inhibited by AG1478.	N-(2-naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
32848840-15	2020	The effects of TNF-alpha and GlyH-101 on IL-8 expression were additive and inhibited by AG1478.	RTKI cpd	88-94	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
32848840-17	2020	The antioxidant N-acetyl cysteine significantly reduced ROS production and the increase in IL-8 and VEGF expression following CFTR inhibition.	Acetylcysteine	16-33	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
32792990-6	2020	In subsequent dose response studies, medroxyprogesterone acetate, but not progesterone, at doses of 10-6-10-8 M inhibited interleukin-1beta induced interleukin-8 and matrix metalloproteinase 1 mRNA expression.	Medroxyprogesterone Acetate	37-64	C-X-C motif chemokine ligand 8	Homo sapiens	148-161
32720061-0	2022	18F-NaF PET uptake characteristics of coronary artery culprit lesions in a cohort of patients of acute coronary syndrome with ST-elevation myocardial infarction and chronic stable angina: A hybrid fluoride PET/CTCA study.	Fluorides	197-205	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
32792990-6	2020	In subsequent dose response studies, medroxyprogesterone acetate, but not progesterone, at doses of 10-6-10-8 M inhibited interleukin-1beta induced interleukin-8 and matrix metalloproteinase 1 mRNA expression.	Progesterone	44-56	C-X-C motif chemokine ligand 8	Homo sapiens	148-161
32792990-7	2020	We further demonstrated that inhibition of glucocorticoid receptor expression, but not progesterone receptor membrane component 1 knockdown with small interfering RNA transfection, resulted in a reversal in medroxyprogesterone acetate"s (10-7 M) inhibition of interleukin-1beta- induced matrix metalloproteinase 1 mRNA expression and interleukin-8 mRNA expression and protein expression.	Medroxyprogesterone Acetate	207-234	C-X-C motif chemokine ligand 8	Homo sapiens	334-347
32694172-10	2020	Because increased IL-8 and CXCL1 production in tumors is associated with increased metastatic potential and cell seeding, poor prognosis, and enhanced recruitment of tumor-associated macrophages and fibroblasts, we propose that inhibition of host-cell binding and invasion, potentially through vaccination or novel galactoside compounds, could be an effective strategy for reducing F. nucleatum-associated CRC metastasis.	Galactosides	315-326	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
33013263-0	2020	Development of a novel in vitro assay to evaluate environmental water using an IL-8 reporter cell line.	Water	64-69	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
33013263-2	2020	Considering these characteristics, we examined the ability of the IL-8 luciferase assay using THP-G8 cells to evaluate water pollution.	Water	119-124	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
33013263-9	2020	These data suggest the potential of the IL-8 luciferase assay for evaluating environmental water pollution both quantitatively and qualitatively.	Water	91-96	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
32703950-3	2020	An intermediate liquid phase-Na2Mo2O7 is formed through a eutectic reaction of MoO3 and NaF, followed by being sulfurized into MoS2.	na2mo2o7	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	88-91
32703950-3	2020	An intermediate liquid phase-Na2Mo2O7 is formed through a eutectic reaction of MoO3 and NaF, followed by being sulfurized into MoS2.	mos2	127-131	C-X-C motif chemokine ligand 8	Homo sapiens	88-91
32515977-8	2020	Among all the tested parameters, only ROS concentrations exhibited consistency with cell viability, and showed significant correlations with the expression levels of CYP1A1, HIF-1a, and especially with IL-8 (the marker for oxidative stress within the cell).	Reactive Oxygen Species	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
32223225-5	2020	Our in vitro data demonstrate an increase in pro-inflammatory cytokines IL-6 and IL-8 levels in response to vaped PG and GLY exposures.	Propylene Glycol	114-116	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
32223225-5	2020	Our in vitro data demonstrate an increase in pro-inflammatory cytokines IL-6 and IL-8 levels in response to vaped PG and GLY exposures.	Glycerol	121-124	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
32685389-9	2020	Inhibiting ERK1/2 phosphorylation by LY3214996 reversed changes in VEGFR2 knockdown-induced IL-8 upregulation at the mRNA and the protein levels with no effects on cell viability.	LY3214996	37-46	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
32601180-3	2020	We had shown that the peptide neurotensin (NT) is increased in the serum of children with ASD and stimulates cultured adult human microglia to secrete the proinflammatory molecules IL-1beta and CXCL8.	Peptides	22-29	C-X-C motif chemokine ligand 8	Homo sapiens	194-199
32676905-1	2021	BACKGROUND: Increased uptake of 18F-Sodium fluoride (18F-NaF) PET has potential to identify atherosclerotic plaques that are vulnerable to rupture.	18f-sodium fluoride	32-51	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
32708494-8	2020	SCFAs (except hexanoic acid) increased ApoA-I mRNA transcription in both normal and inflammatory conditions and lowered IL-8 mRNA expression.	hexanoic acid	14-27	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
31036393-11	2020	CONCLUSION: Plant derived essential oils and related active compounds have potential therapeutic activity for the treatment of asthma by modulating the release of pro-inflammatory (TNF-alpha, IL-1beta, IL-8), Th17 (IL-17), anti-inflammatory (IL-10), Th1 (IFN-gamma, IL-2, IL-12) and Th2 (IL-4, IL-5, IL-6, IL-13) cytokines and the suppression of inflammatory cell accumulation.	Oils, Volatile	26-40	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
32674502-6	2020	In addition, PCG significantly decreased PAR2-induced increases in ICAM-1 and VCAM-1 as well as in IL-8, IFN-gamma, and TNF-alpha expression.	punicalagin	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
32510220-8	2020	However, concentrations of PFOS and 6:2 Cl-PFESA were both significantly and positively associated with MCP-1 levels, while PFOA was inversely associated with IL-8.	perfluorooctanoic acid	124-128	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
32238729-4	2020	Administration of steroid and high-dose intravenous immunoglobulin (1 g/kg) did not alleviate fever or reduce cytokine production; however, after administration of etoposide (an antineoplastic agent), fever decreased immediately, the patient"s general condition improved, and levels of IL-6, IL-10, IL-8, MCP-1, IFN-gamma, and TNF-alpha declined after etoposide administration.	Etoposide	164-173	C-X-C motif chemokine ligand 8	Homo sapiens	299-303
32615949-10	2020	CONCLUSION: Collectively, the unique mechanism of etoposide with G-CSF-induced mobilization is associated with IL-8 secretion from the BMSCs, which is responsible for the enhanced proliferation and mobilization of HSCs in the bone marrow; this was not observed with mobilization using cyclophosphamide with G-CSF or G-CSF alone.	Etoposide	50-59	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
32684872-0	2020	Tritiated Water Induces Toxicity in Human Umbilical Vein Vascular Endothelial Cells via IL8.	Water	10-15	C-X-C motif chemokine ligand 8	Homo sapiens	88-91
32615949-10	2020	CONCLUSION: Collectively, the unique mechanism of etoposide with G-CSF-induced mobilization is associated with IL-8 secretion from the BMSCs, which is responsible for the enhanced proliferation and mobilization of HSCs in the bone marrow; this was not observed with mobilization using cyclophosphamide with G-CSF or G-CSF alone.	Cyclophosphamide	285-301	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
32615949-0	2020	Etoposide-mediated interleukin-8 secretion from bone marrow stromal cells induces hematopoietic stem cell mobilization.	Etoposide	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	19-32
32608284-0	2020	Up-regulation of miR-20a weakens inflammation and apoptosis in high-glucose-induced renal tubular cell mediating diabetic kidney disease by repressing CXCL8 expression.	Glucose	68-75	C-X-C motif chemokine ligand 8	Homo sapiens	151-156
32615949-6	2020	In in vitro experiments, etoposide triggered interleukin (IL)-8 secretion from the BMSCs and caused long-term BMSC toxicity.	Etoposide	25-34	C-X-C motif chemokine ligand 8	Homo sapiens	45-63
32615949-9	2020	In animal studies, the etoposide with G-CSF mobilization group presented higher IL-8-related cytokine and MMP9 expression and lower SDF-1 expression in the BM, compared to the groups not treated with etoposide.	Etoposide	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
32661687-13	2020	In contrast, TiO2 significantly decreased cell viability and increased interleukin-8 release in fibroblast monolayers.	titanium dioxide	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
32375543-0	2020	18F-Sodium Fluoride (18F-NaF) for Imaging Microcalcification Activity in the Cardiovascular System.	18f-sodium fluoride	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
32375543-2	2020	Calcification activity can now be imaged using 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) in combination with either computed tomography or magnetic resonance.	18f-sodium fluoride	47-66	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
31734781-1	2020	AIMS: To investigate the benefit of utilizing 18F-sodium fluoride (NaF) PET/CT over calcium and Framingham scoring for potential preventative coronary artery disease (CAD) intervention.	Sodium Fluoride	46-65	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
32388485-8	2020	Notably, longifolioside A disrupted the interaction between human TLR4 and the TIR domain-containing adaptor protein (TIRAP), an early step during TLR4 activation, thereby reducing IL-8 secretion in 293/HA-hTLR4 cells.	Longifolioside A	9-25	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
31786626-6	2020	18F-fluorodeoxyglucose (FDG) (49/53) and 18F-sodium fluoride (NaF) (5/53) were the most utilized tracers to visualize carotid wall inflammation and microcalcification, respectively.	Sodium Fluoride	41-60	C-X-C motif chemokine ligand 8	Homo sapiens	62-65
32141941-6	2020	RESULTS: Pretreatment with 10 M DHT or 17-beta-estradiol inhibited the high osmolarity-induced expression of TNF-alpha, IL-8, and IL-6.	Dihydrotestosterone	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
32141941-6	2020	RESULTS: Pretreatment with 10 M DHT or 17-beta-estradiol inhibited the high osmolarity-induced expression of TNF-alpha, IL-8, and IL-6.	Estradiol	39-56	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
32352600-0	2020	The association between interleukin-8 levels and the development of withdrawal symptoms during methamphetamine abstinence.	Methamphetamine	95-110	C-X-C motif chemokine ligand 8	Homo sapiens	24-37
32550884-7	2020	Furthermore, icariin significantly increased protein expression of the anti-inflammatory factor interleukin (IL)-10 and significantly decreased protein expression of the pro-inflammatory factors IL-8 and tumor necrosis factor alpha.	icariin	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
31897585-1	2020	PURPOSE: 18F-Sodium fluoride (18F-NaF) positron emission tomography (PET) has the potential to detect high-risk coronary plaques.	18f-sodium fluoride	9-28	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
31897585-8	2020	Focal 18F-NaF uptake in each plaque was quantified using the maximum tissue-to-background ratio (TBRmax).	tbrmax	97-103	C-X-C motif chemokine ligand 8	Homo sapiens	10-13
31897586-1	2020	PURPOSE: 18F-sodium fluoride (18F-NaF) has shown promise in assessing disease activity in coronary arteries, but currently used measures of activity - such as maximum target to background ratio (TBRmax) - are defined by single pixel count values.	18f-sodium fluoride	9-28	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
32352600-8	2020	Serum IL-8 levels remained associated with the severity of METH withdrawal symptoms (beta = .363, p = .023), after adjusting for potential confounders.	Methamphetamine	59-63	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
32352600-13	2020	CONCLUSIONS: Our study demonstrated that higher serum IL-8 levels may predict more severe withdrawal symptoms at 2 weeks after METH abstinence.	Methamphetamine	127-131	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
31629684-1	2020	PURPOSE: This study aimed to elucidate the effects of hydrogen peroxide (H2O2) and sodium fluoride (NaF) on titanium surfaces under conditions mimicking those encountered during dental treatment.	Sodium Fluoride	83-98	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
32361568-9	2020	DMSO-HL and ATRA-HL cells both produced TNF-alpha and IL-8 after lipopolysaccharide (LPS) or PM treatment, whereas non-differentiated HL-60 cells did not.	Tretinoin	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
33149400-4	2020	They were allocated to group I (GI) (5% NaF), group II (GII) [5% NaF with amorphous calcium phosphate (ACP)], and group III (GIII) [5% NaF with casein phosphopeptides - amorphous calcium phosphate (CPP -ACP)].	amorphous	74-83	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
33149400-4	2020	They were allocated to group I (GI) (5% NaF), group II (GII) [5% NaF with amorphous calcium phosphate (ACP)], and group III (GIII) [5% NaF with casein phosphopeptides - amorphous calcium phosphate (CPP -ACP)].	amorphous	74-83	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
33149400-4	2020	They were allocated to group I (GI) (5% NaF), group II (GII) [5% NaF with amorphous calcium phosphate (ACP)], and group III (GIII) [5% NaF with casein phosphopeptides - amorphous calcium phosphate (CPP -ACP)].	amorphous calcium phosphate	74-101	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
33149400-4	2020	They were allocated to group I (GI) (5% NaF), group II (GII) [5% NaF with amorphous calcium phosphate (ACP)], and group III (GIII) [5% NaF with casein phosphopeptides - amorphous calcium phosphate (CPP -ACP)].	amorphous calcium phosphate	74-101	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
32380135-13	2020	CONCLUSIONS: Dab-on with NaF and SnF2 or brushing with SnF2 reduces DH in eroded dentine.	diazobenzenesulfonic acid	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
31629684-1	2020	PURPOSE: This study aimed to elucidate the effects of hydrogen peroxide (H2O2) and sodium fluoride (NaF) on titanium surfaces under conditions mimicking those encountered during dental treatment.	Titanium	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
32377746-8	2020	It was also demonstrated that DHMEQ exposure significantly decreased the levels of interleukin (IL)-8 and monocyte chemoattractant protein-1 (MCP-1) in the supernatant of cultured ARPE-19 cells as determined by ELISA.	dehydroxymethylepoxyquinomicin	30-35	C-X-C motif chemokine ligand 8	Homo sapiens	83-101
31773201-13	2020	In addition, ISB with DEX showed lower mean plasma IL-6 and IL-8 levels than ISB alone within 48 h postoperatively, with delayed rebound pain.	Dexmedetomidine	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
32030555-10	2020	After 10 days, compared to after 5 days, a reduced tissue loss was observed in all groups treated with AmF/NaF/SnCl2 solution.	stannous chloride	111-116	C-X-C motif chemokine ligand 8	Homo sapiens	107-110
32030555-12	2020	Short-pulsed CO2 9.3 mum laser irradiation followed by additional application of AmF/NaF/SnCl2 solution significantly reduces the progression of dental enamel erosion in vitro.	Amphotericin B	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
32030555-12	2020	Short-pulsed CO2 9.3 mum laser irradiation followed by additional application of AmF/NaF/SnCl2 solution significantly reduces the progression of dental enamel erosion in vitro.	stannous chloride	89-94	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
32377746-9	2020	Moreover, the protein expression levels of IL-8 and MCP-1 were significantly reduced in ARPE-19 cells exposed to DHMEQ compared with cells exposed to dexamethasone.	dehydroxymethylepoxyquinomicin	113-118	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
32377746-9	2020	Moreover, the protein expression levels of IL-8 and MCP-1 were significantly reduced in ARPE-19 cells exposed to DHMEQ compared with cells exposed to dexamethasone.	Dexamethasone	150-163	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
32490857-6	2020	The polyphenols and their microbial metabolites alleviate IBD through reduction of oxidative stress, inhibition of inflammatory cytokines secretion (TNF-alpha, IL-6, IL-8, and IL-1beta), suppression of NF-kappaB, upregulation of Nrf2, gut barrier protection, and modulation of immune function.	Polyphenols	4-15	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
32452426-0	2020	Glibenclamide alters interleukin-8 and interleukin-1beta of primary human monocytes from diabetes patients against Mycobacterium tuberculosis infection.	Glyburide	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	21-34
32452426-2	2020	Our previous study showed glibenclamide, an anti-diabetic drug used to control blood glucose concentration, reduced interleukin (IL)-8 secretion from primary human monocytes challenged with M. tuberculosis (Mtb).	Glyburide	26-39	C-X-C motif chemokine ligand 8	Homo sapiens	116-134
32452426-6	2020	We demonstrate that monocytes from diabetes patients who were being treated with glibenclamide showed reduced IL-1beta and IL-8 secretion when exposed to Mtb.	Glyburide	81-94	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
32452426-9	2020	Taken together, our data show that glibenclamide might exacerbate susceptibility of diabetes patients to Mtb infection by reducing IL-1beta and IL-8 production by monocytes.	Glyburide	35-48	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
32605011-0	2020	In Vitro and In Vivo Assessment of PEGylated PEI for Anti-IL-8/CxCL-1 siRNA Delivery to the Lungs.	pegylated pei	35-48	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
32573468-9	2020	Higher stability of remdesivir and metabolite was observed on NaF-plasma.	remdesivir	20-30	C-X-C motif chemokine ligand 8	Homo sapiens	62-65
32553260-2	2020	Coronary 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) provides an assessment of atherosclerosis activity.	18f-sodium fluoride	9-28	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
32685267-1	2020	BACKGROUND: We used 18F-sodium fluoride (NaF) to assess early atherosclerosis in the global heart in asymptomatic individuals with a coronary calcium score of zero and without a formal diagnosis of hypertension.	18f-sodium fluoride	20-39	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
32564053-7	2020	RESULTS Compared with the healthy controls, the serum expression of IL-18, IL-33, IFN-gamma, IL-5, IL-6, IL-8, and IL-13 were significantly higher in the MPP and NMPP groups.	nmpp	162-166	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
32569211-4	2020	Meanwhile, MIR103 and MIR107 were negatively correlated with acute pathologic and chronic health evaluation (APACHE) II score, sequential organ failure assessment (SOFA) score, serum creatinine, C-reactive protein, tumor necrosis factor, interleukin 1beta, interleukin 6 and interleukin 8, while positively correlated with albumin in sepsis patients.	mir103	11-17	C-X-C motif chemokine ligand 8	Homo sapiens	275-288
32570911-6	2020	RESULTS: Our data showed that ZnO was able to reduce the inflammatory response of DECs, in terms of vascular cell adhesion molecule-1 (VCAM-1), interleukin (IL)-8, IL-6, tumor necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1) expression induced by TNF-alpha stimulation.	Zinc Oxide	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	144-162
32676215-0	2020	Interleukin-8 in Hyperlipidemia and Coronary Heart Disease in Thai Patients Taking Statin Cholesterol-Lowering Medication While Undergoing Coronary Artery Bypass Grafting Treatment.	statin cholesterol	83-101	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
32676215-2	2020	This cross-sectional study investigates the association of the IL-8 expression in hyperlipidemia (H) and CHD patients who have been treated with statin cholesterol-lowering drugs while undergoing coronary artery bypass grafting treatment.	Cholesterol	152-163	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
32595508-4	2020	A dichloromethane extract (OS1), mainly composed of isoflavonoids and triterpenes as characterized by LC-MS, showed a concentration-dependent (25-100 mug/ml) inhibition of IL-8 and TNF-alpha release from LPS-stimulated human neutrophils.	Methylene Chloride	2-17	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
31759072-0	2020	Acute alcohol consumption alters the peripheral cytokines IL-8 and TNF-alpha.	Alcohols	6-13	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
32545315-1	2020	The study aimed to analyze morphological and functional changes of Staphylococcus aureus cells due to trans-anethole (a terpenoid and the major constituent of fennel, anise, or star anise essential oils) exposition, and their consequences for human neutrophils phagocytic activity as well as IL-8 production (recognized as the major chemoattractant).	anethole	102-116	C-X-C motif chemokine ligand 8	Homo sapiens	292-296
32545315-7	2020	Additionally, IL-8 production was at a higher level for trans-anethole modified bacteria.	anethole	56-70	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
32551386-6	2020	NAC-related increase in glutathione was associated with significant alterations in tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, IL-8 and IL-10 levels secreted in the culture medium.	Acetylcysteine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
32551386-6	2020	NAC-related increase in glutathione was associated with significant alterations in tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, IL-8 and IL-10 levels secreted in the culture medium.	Glutathione	24-35	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
32551386-7	2020	A substantial decrease in the IL-6, IL-8 and TNF-alpha levels in the culture medium supplemented with NAC was obvious in hepatocytes recovered 14 days after differentiation.	Acetylcysteine	102-105	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
32595508-4	2020	A dichloromethane extract (OS1), mainly composed of isoflavonoids and triterpenes as characterized by LC-MS, showed a concentration-dependent (25-100 mug/ml) inhibition of IL-8 and TNF-alpha release from LPS-stimulated human neutrophils.	Triterpenes	70-81	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
31759072-7	2020	RESULTS: The pro-inflammatory chemokine IL-8 significantly increased 6 hours after alcohol (F(1,34)=4.13, p=0.0002, d"=0.5).	Alcohols	83-90	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
31759072-10	2020	CONCLUSIONS: In our exploratory data, acute alcohol challenge (120 mg/dL) elicits dynamic changes in the pro-inflammatory molecules IL-8 and TNF-alpha.	Alcohols	44-51	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
33911737-6	2020	Results: Interleukin-8 (IL-8) and tumor necrosis factor (TNF)-alpha release was suppressed when keratinocytes were co-treated with oligo-HAs and LL-37 compared with keratinocytes treated with LL-37 only.	Oligosaccharides	131-140	C-X-C motif chemokine ligand 8	Homo sapiens	9-22
33911737-6	2020	Results: Interleukin-8 (IL-8) and tumor necrosis factor (TNF)-alpha release was suppressed when keratinocytes were co-treated with oligo-HAs and LL-37 compared with keratinocytes treated with LL-37 only.	Oligosaccharides	131-140	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
32028158-6	2020	Phosphorus transformed from water-soluble phosphorus (Ca(H2PO4)2, Ca(HPO4)) into insoluble Ca3(PO4)2.20 reducing-oxidizing cycles were investigated, and a less and less fluorine content in oxygen carrier was found because its phase transformation from solid NaF to gaseous HF, and the phosphorus content in oxygen carrier changed slightly under the current conditions.	Phosphorus	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	258-261
31840936-12	2020	Metformin or AICAR presence decreased spontaneous production of IL-6, IL-8 and MCP-1 in RA synovial explants and SFCs (n=5-7).	Metformin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
31840936-12	2020	Metformin or AICAR presence decreased spontaneous production of IL-6, IL-8 and MCP-1 in RA synovial explants and SFCs (n=5-7).	AICA ribonucleotide	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
32058033-9	2020	EPA and DHA also significantly lowered production of monocyte chemoattractant protein 1, interleukin (IL)-6 and IL-8.	Eicosapentaenoic Acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
32058033-9	2020	EPA and DHA also significantly lowered production of monocyte chemoattractant protein 1, interleukin (IL)-6 and IL-8.	Docosahexaenoic Acids	8-11	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
32361849-8	2020	CXCL8 level was significantly upgraded after NAC in CXCR1/2+ patients and downgraded after NAC in CXCR1/2- patients.	nac	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
32361849-8	2020	CXCL8 level was significantly upgraded after NAC in CXCR1/2+ patients and downgraded after NAC in CXCR1/2- patients.	nac	91-94	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
32361849-13	2020	The CXCL8-CXCR1/2 might play an important role in tailoring and modifying the NAC strategy for advanced TNBCs; however, further confirmatory studies are needed.	nac	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	4-9
32286869-15	2020	Fluorine-18-labeled NaF PET/CT showed axial bone lesions with bone formation and can be used as a monitoring tool in patients with AS receiving anti-TNF-alpha drugs.	Fluorine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	20-23
32088457-5	2020	30% RM converted water-soluble NaF into more stable CaF2 than did SPL at 850  C, thus reducing the leaching rate by 45.15%.	Water	17-22	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
32602468-10	2020	At the T1D onset, the concentrations of Fetuin-A (p=0.031) and IL-8 (p=0.042) were significantly higher in patients compared to those without CPR.	cpr	142-145	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
32088457-8	2020	SiO2 and Al2O3 exerted a thermally positive effect on NaF turning into CaF2.	Silicon Dioxide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
32088457-8	2020	SiO2 and Al2O3 exerted a thermally positive effect on NaF turning into CaF2.	Aluminum Oxide	9-14	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
32088457-9	2020	The fluoride retention of the bottom ash was mainly dominated by CaF2 and NaF with(out) RM.	Fluorides	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
32199215-3	2020	Our study showed that treating human bronchial epithelial (16HBE) cells with neodymium oxide caused an inflammatory response by upregulating the expression of interleukin-8 (IL-8) and interleukin-1 beta (IL-1beta).	neodymium oxide	77-92	C-X-C motif chemokine ligand 8	Homo sapiens	159-172
32199215-3	2020	Our study showed that treating human bronchial epithelial (16HBE) cells with neodymium oxide caused an inflammatory response by upregulating the expression of interleukin-8 (IL-8) and interleukin-1 beta (IL-1beta).	neodymium oxide	77-92	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
32199215-7	2020	Moreover, circ_0000638 reduced the expression of IL-8 and IL-1beta by inhibiting NF-kappaB activation in neodymium oxide-treated 16HBE cells.	circ_0000638	10-22	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
32199215-7	2020	Moreover, circ_0000638 reduced the expression of IL-8 and IL-1beta by inhibiting NF-kappaB activation in neodymium oxide-treated 16HBE cells.	neodymium oxide	105-120	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
32199215-7	2020	Moreover, circ_0000638 reduced the expression of IL-8 and IL-1beta by inhibiting NF-kappaB activation in neodymium oxide-treated 16HBE cells.	16hbe	129-134	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
32199215-8	2020	These results suggest that circ_0000638 can inhibit NF-kappaB activation by competitively binding to miR-498-5p, further downregulating the expression of IL-8 and IL-1beta in neodymium oxide-treated 16HBE cells.	circ_0000638	27-39	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
32199215-8	2020	These results suggest that circ_0000638 can inhibit NF-kappaB activation by competitively binding to miR-498-5p, further downregulating the expression of IL-8 and IL-1beta in neodymium oxide-treated 16HBE cells.	neodymium oxide	175-190	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
32199215-8	2020	These results suggest that circ_0000638 can inhibit NF-kappaB activation by competitively binding to miR-498-5p, further downregulating the expression of IL-8 and IL-1beta in neodymium oxide-treated 16HBE cells.	16hbe	199-204	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
31609478-8	2020	Gene expression analysis in PDAC tumors (n = 63) showed a positive correlation between the expression of NOS2 and the tryptophan/kynurenine pathway genes, including indoleamine-2,3-dioxygenase 1 (IDO1) and several aryl hydrocarbon receptor (AHR)-target genes including NFE2L2 (NRF2), SERPINB2, IL1b, IL6 and IL8, which are implicated in pancreatic cancer.	Kynurenine	129-139	C-X-C motif chemokine ligand 8	Homo sapiens	308-311
32179246-4	2020	Our results indicate that alogliptin treatment ameliorated IL-1beta-induced production of reactive oxygen species, the expression of matrix metalloproteinase-3 (MMP-3) and MMP-13, secretions of tumor necrosis factor-alpha (TNF-alpha), IL-6, and IL-8.	alogliptin	26-36	C-X-C motif chemokine ligand 8	Homo sapiens	245-249
31773235-1	2020	PURPOSE: We examined the literature to elucidate the role of 18F-sodium fluoride (NaF)-PET in atherosclerosis.	Sodium Fluoride	61-80	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
31925623-3	2020	The results showed that THP-1 cells, which were stimulated by LAMPs after pretreatment with H2S, had decreased production of interleukin-6 (IL-6) and interleukin-8 (IL-8) by inhibiting the mitogen-activated protein kinases (MAPKs)/nuclear factor-kappa B (NF-kappaB) signaling pathway and increased expression of HO-1 by activating the nuclear factor E2-related factor 2 (Nrf2) signaling pathway.	hydrogen sulfite	92-95	C-X-C motif chemokine ligand 8	Homo sapiens	150-163
31925623-3	2020	The results showed that THP-1 cells, which were stimulated by LAMPs after pretreatment with H2S, had decreased production of interleukin-6 (IL-6) and interleukin-8 (IL-8) by inhibiting the mitogen-activated protein kinases (MAPKs)/nuclear factor-kappa B (NF-kappaB) signaling pathway and increased expression of HO-1 by activating the nuclear factor E2-related factor 2 (Nrf2) signaling pathway.	hydrogen sulfite	92-95	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
31925623-4	2020	Our results indicate that H2S may play an important role in attenuating inflammation induced by M. pneumoniae LAMPs due to its ability to decrease the production of IL-6 and IL-8 and increase the expression of the HO-1.	hydrogen sulfite	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
32602468-11	2020	CONCLUSION: Evaluation of Fetuin-A and IL-8 levels in patients with a newly diagnosed T1D can differentiate between patients with or without CPR.	cpr	141-144	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
32431334-3	2020	CPH digests significantly inhibited the expression of cyclooxygenase-2 and inducible nitric oxide synthase, and reduced the secretion of interleukin-8 in TNF-alpha-induced inflammation in Caco-2 cells.	cph	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	137-150
32037273-11	2020	Methylprednisolone reduced the proinflammatory cytokines interleukin-6 and interleukin-8 and increased the anti-inflammatory cytokine interleukin-10 postoperatively.	Methylprednisolone	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	75-88
32374474-5	2020	In the present study, silvestrol down-regulated several pro- and anti-inflammatory cytokines (IL-6, IL-8, IL-10, CCL2, CCL18) and increased TNF-alpha during differentiation and activation of M1-macrophages, suggesting that the effects of silvestrol might cancel each other out.	silvestrol	22-32	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
32374474-6	2020	However, silvestrol amplified the anti-inflammatory potential of M2-macrophages by increasing expression of anti-inflammatory surface markers CD206, TREM2 and reducing release of pro-inflammatory IL-8 and CCL2.	silvestrol	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
32589092-5	2020	Moreover, AZM can inhibit the ability of TNF-alpha-to induce interleukin (IL)-8 production.	Azithromycin	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	61-79
32589092-6	2020	This review focuses on the effects on AZM that may be beneficial in inhibiting MUC5AC, matrix metalloprotease-9 and IL-8 production in airway epithelial cells.	Azithromycin	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
32179074-3	2020	KEY FINDINGS: Pre-treatment with quercetin significantly reversed the LPS-induced upregulation of pro-fibrotic factors (IL-6, IL-8, COL-1, COL-3, LC3) and fibrotic signaling mediators (mTOR and AKT), and it induced the downregulation of ATG5 in the WI-38 cells.	Quercetin	33-42	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
32069432-6	2020	MCP-1 and GM-CSF levels, as well as gene expressions of IL-6 and IL-8 in HTR8/SVneo cells were greatly increased by TNF-alpha (5, 10 and 20 ng/mL), but reversed by sevoflurane and SB203580.	sevoflurane	164-175	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
32069432-6	2020	MCP-1 and GM-CSF levels, as well as gene expressions of IL-6 and IL-8 in HTR8/SVneo cells were greatly increased by TNF-alpha (5, 10 and 20 ng/mL), but reversed by sevoflurane and SB203580.	SB 203580	180-188	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
30684262-1	2020	INTRODUCTION: 18F-Sodium Fluoride Positron Emission Tomography (18F-NaF PET) is a novel molecular imaging modality with promise for use as a risk stratification tool in cardiovascular disease.	18f-sodium fluoride	14-33	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
32219875-7	2020	DSR-6434 triggered 20-fold lower levels of IFN-alpha by pDCs, but higher production of IL-6, IL-8 and TNF, compared to RNA-IC.	DSR-6434	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
31833613-8	2020	Diosmetin treatment resulted in an increase in apoptotic rates and a reduction in TNF-alpha-induced production of IL-1beta, IL-6, IL-8, and MMP-1 in MH7A cells.	diosmetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
32483313-5	2020	Increased cytokines IL-6 as well as IL-8 were released by resistant cells, along with increased mammospheres and induction of EMT, all of which was inhibited by propofol.	Propofol	161-169	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
32615160-12	2020	In addition, combining bergenin and dexamethasone (DEX) yielded additive effects on the reduction of IL-6 and IL-8 expression.	bergenin	23-31	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
32615160-12	2020	In addition, combining bergenin and dexamethasone (DEX) yielded additive effects on the reduction of IL-6 and IL-8 expression.	Dexamethasone	36-49	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
32615160-12	2020	In addition, combining bergenin and dexamethasone (DEX) yielded additive effects on the reduction of IL-6 and IL-8 expression.	Dexamethasone	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
32596498-8	2020	IL-8 and TNF-alpha cytokines showed milder increases of DAPI, MPO, and CitH3 positive cells.	DAPI	56-60	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
32062016-0	2020	Soluble silver ions from silver nanoparticles induce a polarised secretion of interleukin-8 in differentiated Caco-2 cells.	Silver	8-14	C-X-C motif chemokine ligand 8	Homo sapiens	78-91
32062016-0	2020	Soluble silver ions from silver nanoparticles induce a polarised secretion of interleukin-8 in differentiated Caco-2 cells.	Silver	25-31	C-X-C motif chemokine ligand 8	Homo sapiens	78-91
32062016-4	2020	In this context, the present study aims at assessing the impact of silver nanoparticles on the secretion of the pro-inflammatory chemokine interleukin-8 by Caco-2 cells forming an in vitro model of the intestinal mucosal barrier.	Silver	67-73	C-X-C motif chemokine ligand 8	Homo sapiens	139-152
32062016-5	2020	Silver nanoparticles induced a vectorized secretion of interleukin-8 towards the apical compartment, which is found in the medium 21 hours after the incubation.	Silver	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	55-68
32062016-7	2020	The soluble silver fraction of silver nanoparticles suspensions led to a similar amount of secreted interleukin-8 than silver nanoparticles, suggesting an involvement of silver ions in this interleukin-8 secretion.	Silver	12-18	C-X-C motif chemokine ligand 8	Homo sapiens	100-113
32062016-7	2020	The soluble silver fraction of silver nanoparticles suspensions led to a similar amount of secreted interleukin-8 than silver nanoparticles, suggesting an involvement of silver ions in this interleukin-8 secretion.	Silver	12-18	C-X-C motif chemokine ligand 8	Homo sapiens	190-203
32062016-7	2020	The soluble silver fraction of silver nanoparticles suspensions led to a similar amount of secreted interleukin-8 than silver nanoparticles, suggesting an involvement of silver ions in this interleukin-8 secretion.	Silver	31-37	C-X-C motif chemokine ligand 8	Homo sapiens	100-113
32062016-7	2020	The soluble silver fraction of silver nanoparticles suspensions led to a similar amount of secreted interleukin-8 than silver nanoparticles, suggesting an involvement of silver ions in this interleukin-8 secretion.	Silver	31-37	C-X-C motif chemokine ligand 8	Homo sapiens	190-203
32062016-7	2020	The soluble silver fraction of silver nanoparticles suspensions led to a similar amount of secreted interleukin-8 than silver nanoparticles, suggesting an involvement of silver ions in this interleukin-8 secretion.	Silver	31-37	C-X-C motif chemokine ligand 8	Homo sapiens	100-113
32062016-7	2020	The soluble silver fraction of silver nanoparticles suspensions led to a similar amount of secreted interleukin-8 than silver nanoparticles, suggesting an involvement of silver ions in this interleukin-8 secretion.	Silver	31-37	C-X-C motif chemokine ligand 8	Homo sapiens	190-203
32062016-7	2020	The soluble silver fraction of silver nanoparticles suspensions led to a similar amount of secreted interleukin-8 than silver nanoparticles, suggesting an involvement of silver ions in this interleukin-8 secretion.	Silver	31-37	C-X-C motif chemokine ligand 8	Homo sapiens	100-113
32062016-7	2020	The soluble silver fraction of silver nanoparticles suspensions led to a similar amount of secreted interleukin-8 than silver nanoparticles, suggesting an involvement of silver ions in this interleukin-8 secretion.	Silver	31-37	C-X-C motif chemokine ligand 8	Homo sapiens	190-203
32469940-4	2020	In the present study carried out in whole blood, heparin and selectively desulfated heparin reduced histone induced inflammatory markers such as interleukin 6 (IL 6), interleukin 8 (IL 8) and tissue factor and C3a, a complement component.	Heparin	49-56	C-X-C motif chemokine ligand 8	Homo sapiens	167-180
32469940-4	2020	In the present study carried out in whole blood, heparin and selectively desulfated heparin reduced histone induced inflammatory markers such as interleukin 6 (IL 6), interleukin 8 (IL 8) and tissue factor and C3a, a complement component.	Heparin	49-56	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
32469940-4	2020	In the present study carried out in whole blood, heparin and selectively desulfated heparin reduced histone induced inflammatory markers such as interleukin 6 (IL 6), interleukin 8 (IL 8) and tissue factor and C3a, a complement component.	Heparin	84-91	C-X-C motif chemokine ligand 8	Homo sapiens	167-180
32469940-4	2020	In the present study carried out in whole blood, heparin and selectively desulfated heparin reduced histone induced inflammatory markers such as interleukin 6 (IL 6), interleukin 8 (IL 8) and tissue factor and C3a, a complement component.	Heparin	84-91	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
32456181-2	2020	Sodium fluoride (18F-NaF) is a highly sensitive tracer of bone reconstruction, evolving as an important imaging agent for the assessment of malignant bone diseases.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
32509050-9	2020	The IL-8 level was suppressed more significantly by quercetin metabolites in the perfusion co-culture, as compared to static culture.	Quercetin	52-61	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
32466509-9	2020	Our study indicates that 17-aminogeldanamycin can be used for efficient inhibition of NF-kappaB activity and the simultaneous diminution of IL-8 and VEGF levels in the extracellular milieu of melanoma.	17-aminogeldanamycin	25-45	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
32319286-9	2020	Exposure of differentiated Caco-2 cells to positively or negatively surface-charged SiO2 NPs also upregulated interleukin-8 expression.	Silicon Dioxide	84-88	C-X-C motif chemokine ligand 8	Homo sapiens	110-123
31770582-6	2020	The dexamethasone (Dex) concentration required to achieve 50% inhibition of TNF-alpha-induced interleukin (IL)-8 production was determined and the mitogen-activated protein kinase (MAPK)/Activator protein-1 (AP-1) pathway was also evaluated.	Dexamethasone	4-17	C-X-C motif chemokine ligand 8	Homo sapiens	94-112
31770582-6	2020	The dexamethasone (Dex) concentration required to achieve 50% inhibition of TNF-alpha-induced interleukin (IL)-8 production was determined and the mitogen-activated protein kinase (MAPK)/Activator protein-1 (AP-1) pathway was also evaluated.	Dexamethasone	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	94-112
32481266-9	2020	Meanwhile, the area under the curve (AUC) of IL-8 in EBC was significantly lower at T2 and the AUC of IL-6 in EBC was significantly higher at T4 than in serum (P < .05).	NSC638702	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
32434541-11	2020	Cisplatin but not erlotinib increased both IL-6 and IL-8 secretion and only IL-6 increased cellular migration and proliferation.	Cisplatin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
32418407-7	2020	RESULTS: Results obtained in this work demonstrated that CKG is able to prevent the impairment of intestinal barrier function induced by inflammation, ameliorating the transepithelial electrical resistance and the paracellular permeability of the Caco-2 monolayer; moreover, CKG is able to counteract the increased release of TNF-a and IL-8 induced by inflammatory stimulus, thus reducing the intestinal inflammation.	CHEMBL1171949	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	336-340
32414118-7	2020	Consequentially, resveratrol reduced PM-induced cyclooxygenase-2/prostaglandin E2 and proinflammatory cytokine expression, including that of matrix metalloproteinase (MMP)-1, MMP-9, and interleukin-8, all of which are known to be central mediators of various inflammatory conditions and aging.	Resveratrol	17-28	C-X-C motif chemokine ligand 8	Homo sapiens	186-199
32494176-11	2020	Furthermore, deficient 25(OH)D individuals with low HDL-C levels had higher circulatory IL-6 and IL-8 levels, and higher serum soluble TM compared to individuals with sufficient 25(OH)D and normal lipid profiles (median, IL-6 pg/mL 0.82 vs 1.71, P=0.001; median, IL-8 pg/mL 51.31 vs 145.6, P=0.003; and median, soluble TM ng/mL 5.19 vs 7.38, P<0.0001; in sufficient vs deficient groups, respectively).	25(oh)d	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
32494176-11	2020	Furthermore, deficient 25(OH)D individuals with low HDL-C levels had higher circulatory IL-6 and IL-8 levels, and higher serum soluble TM compared to individuals with sufficient 25(OH)D and normal lipid profiles (median, IL-6 pg/mL 0.82 vs 1.71, P=0.001; median, IL-8 pg/mL 51.31 vs 145.6, P=0.003; and median, soluble TM ng/mL 5.19 vs 7.38, P<0.0001; in sufficient vs deficient groups, respectively).	25(oh)d	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	263-267
32370749-10	2020	Meanwhile, sinensetin treatment significantly decreased IAV-induced expression of pro-inflammatory mediators at mRNA and protein levels, including IL-6, TNF-alpha, IP-10, IL-8 and MCP-1.	sinensetin	11-21	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
32397252-2	2020	Our aim was to quantify vascular calcification in the arteries and the deposition of 18F-sodium-fluoride (18F-NaF) in the skin and vessel walls with positron emission tomography/computed tomography.	18f-sodium-fluoride	85-104	C-X-C motif chemokine ligand 8	Homo sapiens	110-113
32440119-1	2020	Objectives: The first objective of this study was to prepare sodium fluoride (NaF) solution with various concentrations of polyethylene glycol-coated silver nanoparticles (PEG-AgNPs).	Sodium Fluoride	61-76	C-X-C motif chemokine ligand 8	Homo sapiens	78-81
32440119-1	2020	Objectives: The first objective of this study was to prepare sodium fluoride (NaF) solution with various concentrations of polyethylene glycol-coated silver nanoparticles (PEG-AgNPs).	polyethylene glycol-coated silver nanoparticles	123-170	C-X-C motif chemokine ligand 8	Homo sapiens	78-81
32440119-1	2020	Objectives: The first objective of this study was to prepare sodium fluoride (NaF) solution with various concentrations of polyethylene glycol-coated silver nanoparticles (PEG-AgNPs).	peg-agnps	172-181	C-X-C motif chemokine ligand 8	Homo sapiens	78-81
32440119-6	2020	The staining effect on dentin and enamel for the 2.5% NaF solutions with PEG-AgNPs at 12,800, 6400, 1600, and 400 ppm was investigated using digital spectrophotometry.	Polyethylene Glycols	73-76	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
32440119-6	2020	The staining effect on dentin and enamel for the 2.5% NaF solutions with PEG-AgNPs at 12,800, 6400, 1600, and 400 ppm was investigated using digital spectrophotometry.	agnps	77-82	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
32440119-8	2020	Results: The PEG-AgNPs have an average diameter of 2.56+-0.43 nm and showed excellent stability at high ionic strength (2.5% NaF) for 18 months.	Polyethylene Glycols	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	125-128
32440119-12	2020	Conclusion: A biocompatible solution of NaF with PEG-AgNPs was developed.	peg-agnps	49-58	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
32366417-9	2020	CONCLUSION: The paracrine interaction between BCa cells and TAMs led to enhanced BCa cell growth, migration, and invasiveness, and moreover, increased IL-8 and CCL5 cytokine production in tumor microenvironment.	Tamoxifen	60-64	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
32431615-0	2020	Free Fatty Acid Receptor 1 Signaling Contributes to Migration, MMP-9 Activity, and Expression of IL-8 Induced by Linoleic Acid in HaCaT Cells.	Fatty Acids, Nonesterified	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
32431615-0	2020	Free Fatty Acid Receptor 1 Signaling Contributes to Migration, MMP-9 Activity, and Expression of IL-8 Induced by Linoleic Acid in HaCaT Cells.	Linoleic Acid	113-126	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
32431615-8	2020	Besides, HaCaT cells stimulated with LA or GW9508 increased the activity of MMP-9 and the expression of IL-8.	GW9508	43-49	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
32431615-12	2020	Furthermore, IL-8 secreted by HaCaT cells stimulated with LA or GW9508, contributed to neutrophil chemotaxis.	GW9508	64-70	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
32200535-4	2020	By inhibition of NF-kappaB, 1,8-cineole, at relevant plasma concentrations (1.5 microg/ml), strongly and significantly inhibited in normal human monocyte lipopolysaccharide (LPS)-stimulated cytokines relevant for exacerbation (tumour necrosis factor alpha (TNFalpha), interleukin (IL)-1beta and systemic inflammation (IL-6, IL-8).	Eucalyptol	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	324-328
32312819-4	2020	To explore this issue, we analyzed secretomes from glucose-deprived cells, which revealed up-regulation of multiple cytokines and chemokines, including IL-6 and IL-8, in response to starvation stress.	Glucose	51-58	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
32312819-7	2020	Furthermore, glutamine deprivation, as well as the antimetabolic drugs 2-deoxyglucose and metformin, also promoted the release of IL-6 and IL-8.	Glutamine	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
32312819-7	2020	Furthermore, glutamine deprivation, as well as the antimetabolic drugs 2-deoxyglucose and metformin, also promoted the release of IL-6 and IL-8.	Deoxyglucose	71-85	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
32312819-7	2020	Furthermore, glutamine deprivation, as well as the antimetabolic drugs 2-deoxyglucose and metformin, also promoted the release of IL-6 and IL-8.	Metformin	90-99	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
31935110-7	2020	The metabolites produced by our consortium increased glycogen synthesis by ~57% and decreased proinflammatory markers such as IL-8 by 12%, thus elucidating the positive effect of our consortium on metabolic function and low-grade inflammation.	Glycogen	53-61	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
32275470-7	2020	Additionally, the upregulated expression of inflammatory cytokines, IL-6 and IL-8, after histamine stimulation was abolished by silencing Orai1 or STIM1 with RNAi in LECs.	Histamine	89-98	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
28861755-0	2020	Clarithromycin decreases rhinovirus replication and cytokine production in nasal epithelial cells from subjects with bronchial asthma: effects on IL-6, IL-8 and IL-33.	Clarithromycin	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	152-156
32088265-4	2020	Chloroquine and hydroxychloroquine increased IL-1beta-induced CXCL8 secretion in macrophages which was critically dependent on the lysosomotropic character and inhibition of macroautophagy but independent from the NLRP3 inflammasome.	Chloroquine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	62-67
32058018-12	2020	RESULTS: There was a statistically significant correlation between fluoride activity in the 18F-NaF PET scan and histomorphometric parameters such as bone formation rate, activation frequency and osteoclast and osteoblast surfaces and mineralized surfaces.	Fluorides	67-75	C-X-C motif chemokine ligand 8	Homo sapiens	96-99
32088265-4	2020	Chloroquine and hydroxychloroquine increased IL-1beta-induced CXCL8 secretion in macrophages which was critically dependent on the lysosomotropic character and inhibition of macroautophagy but independent from the NLRP3 inflammasome.	Hydroxychloroquine	16-34	C-X-C motif chemokine ligand 8	Homo sapiens	62-67
32058018-15	2020	CONCLUSIONS: A clear correlation between histomorphometric parameters and fluoride activity in the 18F-NaF PET scan was established.	Fluorides	74-82	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
32205228-10	2020	Cadmium exposures were associated with increased IL-1beta (beta = 77.8 +- 26.3, p = 0.003) and IL-8 (beta = 419.5 +- 201.2, p = 0.04).	Cadmium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
31677006-10	2020	Plasma levels of IL-1beta, IL-6 and IL-8 were significantly repressed by geniposide treatment in TBI rats, whereas IL-10 level was upregulated.	geniposide	73-83	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
31943712-5	2020	The results showed that nickel could induce cell apoptosis, increase oxidative stress, and promote the expression of pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, C-reaction protein.	Nickel	24-30	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
33073254-7	2020	As expected, DEX treatment suppressed multiple LPS-induced pro-inflammatory cytokines (IFN-gamma, IL-6, IL-8, IL-1beta, .TNF-alpha) by >85% and increased the anti-inflammatory cytokine IL-10 by 80%.	Dexamethasone	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
32277559-9	2020	In addition, incubation of PMN with N-Gel effectively reduced both TNF-alpha and IL-8 mRNA levels.	Nitrogen	29-30	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
32269608-6	2020	IC50-Dex was determined through observation of Dex inhibition of tumor necrosis factor-alpha (TNF-alpha)-induced interleukin (IL)-8 release.	Dexamethasone	5-8	C-X-C motif chemokine ligand 8	Homo sapiens	113-131
32269608-6	2020	IC50-Dex was determined through observation of Dex inhibition of tumor necrosis factor-alpha (TNF-alpha)-induced interleukin (IL)-8 release.	Dexamethasone	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	113-131
32269608-8	2020	Theophylline and Dex pre-treatment was shown to significantly reduce the CSE-induced release of IL-8 and TNF-alpha.	Theophylline	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
32269608-8	2020	Theophylline and Dex pre-treatment was shown to significantly reduce the CSE-induced release of IL-8 and TNF-alpha.	Dexamethasone	17-20	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
32205228-12	2020	Among obese participants (n = 108), benzene, lead, and cadmium were each positively associated with CK18 M30, IL-1beta, IL-6, and IL-8.	Benzene	36-43	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
32205228-12	2020	Among obese participants (n = 108), benzene, lead, and cadmium were each positively associated with CK18 M30, IL-1beta, IL-6, and IL-8.	Cadmium	55-62	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
31760503-2	2020	BT may be identified and characterized using 18-F-sodium fluoride-positron-emission-tomography/computed tomography (18F-NaF-PET/CT).	18-f-sodium fluoride	45-65	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
32045605-14	2020	Slp2 and LC2029 inhibited Il-8 production in Caco-2 and HT-29 cells induced by MALP-2 and increased production of anti-inflammatory cytokine Il-6.	macrophage stimulatory lipopeptide 2	79-85	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
32141631-5	2020	The HC with high levels of IgA-ACPA (n = 27) also had significantly higher levels of total IgG, total IgA, and IL-8 in the GCF than the HC with low levels of IgA-ACPA in the GCF (n = 124).	3-[3-[3-[(4~{s})-6-Azanyl-5-Cyano-3-Methyl-4-Propan-2-Yl-2~{h}-Pyrano[2,3-C]pyrazol-4-Yl]-5-(Trifluoromethyl)phenyl]phenyl]propanoic Acid	123-126	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
32142400-11	2020	Among the reviewed self-applied topical fluoride methods, daily use of a 0.2% sodium fluoride (NaF) mouth rinse is most likely to be the most effective, followed by 1100 ppm to 1500 ppm fluoride toothpaste plus 0.05% NaF mouth rinse, and 1100 ppm to 1500 ppm fluoride toothpaste.	Fluorides	40-48	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
32142400-11	2020	Among the reviewed self-applied topical fluoride methods, daily use of a 0.2% sodium fluoride (NaF) mouth rinse is most likely to be the most effective, followed by 1100 ppm to 1500 ppm fluoride toothpaste plus 0.05% NaF mouth rinse, and 1100 ppm to 1500 ppm fluoride toothpaste.	Sodium Fluoride	78-93	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
32142400-11	2020	Among the reviewed self-applied topical fluoride methods, daily use of a 0.2% sodium fluoride (NaF) mouth rinse is most likely to be the most effective, followed by 1100 ppm to 1500 ppm fluoride toothpaste plus 0.05% NaF mouth rinse, and 1100 ppm to 1500 ppm fluoride toothpaste.	Fluorides	85-93	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
32142400-11	2020	Among the reviewed self-applied topical fluoride methods, daily use of a 0.2% sodium fluoride (NaF) mouth rinse is most likely to be the most effective, followed by 1100 ppm to 1500 ppm fluoride toothpaste plus 0.05% NaF mouth rinse, and 1100 ppm to 1500 ppm fluoride toothpaste.	Fluorides	85-93	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
32171180-8	2020	Stimulation of hpGCs with DHT resulted in downregulation of PEDF mRNA expression, concomitantly with a significant increase in IL-6 and IL-8 mRNAs expression.	Dihydrotestosterone	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
31896762-7	2020	DMPA-cytokine associations frequently differed by vaginal microbiome; in non-Lactobacillus-dominant women, DMPA was associated with elevated IL-8, MCP-1, and IP-10 concentrations.	N,N-dimethyl-4-anisidine	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
32029577-10	2020	Cin significantly inhibited IL-1beta-induced interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-alpha (TNF-alpha) release from human synoviocyte cells.	cinnamaldehyde	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
32029577-10	2020	Cin significantly inhibited IL-1beta-induced interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-alpha (TNF-alpha) release from human synoviocyte cells.	cinnamaldehyde	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
31896762-7	2020	DMPA-cytokine associations frequently differed by vaginal microbiome; in non-Lactobacillus-dominant women, DMPA was associated with elevated IL-8, MCP-1, and IP-10 concentrations.	N,N-dimethyl-4-anisidine	107-111	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
32370100-8	2020	Cell cycle analysis demonstrated that K562 cells treated with Br-Ell-SO3Na were arrested in the phase S. Moreover, the production of IL-6 increased and the expression of IL-8 was inhibited in the human PBMC treated with Br-Ell-SO3Na.	br-ell-so3na	62-74	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
32370100-8	2020	Cell cycle analysis demonstrated that K562 cells treated with Br-Ell-SO3Na were arrested in the phase S. Moreover, the production of IL-6 increased and the expression of IL-8 was inhibited in the human PBMC treated with Br-Ell-SO3Na.	br-ell-so3na	220-232	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
32405062-2	2020	Here, using a large-scale retrospective analysis, we show that elevated baseline serum IL-8 levels are associated with poor outcome in patients (n = 1,344) with advanced cancers treated with nivolumab and/or ipilimumab, everolimus or docetaxel in phase 3 clinical trials, revealing the importance of assessing serum IL-8 levels in identifying unfavorable tumor immunobiology and as an independent biomarker in patients receiving immune-checkpoint inhibitors.	Everolimus	220-230	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
32405062-2	2020	Here, using a large-scale retrospective analysis, we show that elevated baseline serum IL-8 levels are associated with poor outcome in patients (n = 1,344) with advanced cancers treated with nivolumab and/or ipilimumab, everolimus or docetaxel in phase 3 clinical trials, revealing the importance of assessing serum IL-8 levels in identifying unfavorable tumor immunobiology and as an independent biomarker in patients receiving immune-checkpoint inhibitors.	Docetaxel	234-243	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
32126272-3	2020	Owing to its potent antioxidant properties, lycopene can potentially alleviate enhanced levels of proinflammatory mediators (e.g., proinflammatory cytokines IL-8, -6, and -1, and oxidized phospholipids) and prevent NF-kappaB activation by modulating oxidative stress.	Lycopene	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	157-173
32326355-7	2020	Both trichothecenes also enhanced transcript levels of the known NF-kappaB-dependent pro-inflammatory cytokines IL-8, IL-6, TNF-alpha and IL-1beta.	Trichothecenes	5-19	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
32186753-9	2020	Further mechanistic studies indicated that resveratrol exerted anti-inflammatory activity by activating the ERK1/2 pathway, decreasing the secretion of interleukin (IL)-6 and IL-8 induced by TNF-alpha, and enhancing hPDLSCs osteogenesis.	Resveratrol	43-54	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
32354131-6	2020	The DOX-stimulated expression of IkappaBalpha, NF-kappaB, COX-2, and IL-8 were all downregulated by exercise as well as the fibrosis factors (TGF-beta1, phosphorylated ERK, Sp1, and CTGF).	Doxorubicin	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
32368057-1	2020	Objective: To investigate the remineralizing and staining effects of sodium fluoride (NaF) solution with polyethylene glycol-coated silver nanoparticles (PEG-AgNPs) on artificial dentine caries.	Sodium Fluoride	69-84	C-X-C motif chemokine ligand 8	Homo sapiens	86-89
32368057-1	2020	Objective: To investigate the remineralizing and staining effects of sodium fluoride (NaF) solution with polyethylene glycol-coated silver nanoparticles (PEG-AgNPs) on artificial dentine caries.	Polyethylene Glycols	105-124	C-X-C motif chemokine ligand 8	Homo sapiens	86-89
32368057-1	2020	Objective: To investigate the remineralizing and staining effects of sodium fluoride (NaF) solution with polyethylene glycol-coated silver nanoparticles (PEG-AgNPs) on artificial dentine caries.	Silver	132-152	C-X-C motif chemokine ligand 8	Homo sapiens	86-89
32368057-14	2020	Conclusion: The use of NaF solution with PEG-AgNPs can remineralize artificial dentine caries and inhibit collagen degradation without causing significant tooth staining.	Polyethylene Glycols	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
32368057-14	2020	Conclusion: The use of NaF solution with PEG-AgNPs can remineralize artificial dentine caries and inhibit collagen degradation without causing significant tooth staining.	agnps	45-50	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
32365773-0	2020	Sildenafil Reduces Expression and Release of IL-6 and IL-8 Induced by Reactive Oxygen Species in Systemic Sclerosis Fibroblasts.	Sildenafil Citrate	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
32365773-5	2020	Treatment with sildenafil significantly reduced dermal fibroblast gene expression and cellular release of IL-6, known to play a central role in the pathogenesis of tissue damage in SSc and IL-8, directly induced by ROS.	Sildenafil Citrate	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
32365773-5	2020	Treatment with sildenafil significantly reduced dermal fibroblast gene expression and cellular release of IL-6, known to play a central role in the pathogenesis of tissue damage in SSc and IL-8, directly induced by ROS.	Reactive Oxygen Species	215-218	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
32598720-9	2020	68% of patients with exacerbation of CP, receiving in addition to the standard regimen rifaximin, achieved clinical improvement, normalization of intestinal biocenosis, reduced concentrations of cytokines in tissues, reducing signs of chronic inflammation in the colon mucosa with reducing concentrations of IL-2, IL-6, IL-8 in colon mucosa (p0.05).	Rifaximin	87-96	C-X-C motif chemokine ligand 8	Homo sapiens	320-324
32322697-1	2020	Objectives: To evaluate effectiveness of a nasal resveratrol/carboxymethyl-beta-glucan solution compared to nasal saline solution: a) on common cold symptoms by means of a validated measure scale (CARIFS score), b) on Rhinovirus infection and CCL2, CCL5, IL8, IL6, CXCL10 and TLR2 expression in nasal swabs, c) on frequency of relapses after 30 days of follow-up.	Resveratrol	49-60	C-X-C motif chemokine ligand 8	Homo sapiens	255-258
32315368-2	2020	The platelet, one of the main activators of neutrophils, contains Interleukin 8 (IL-8), a potent neutrophil chemo-attractant and P-selectin that induces excretion of superoxide in the neutrophils, forming platelet-neutrophil aggregates that are increased in individuals with active UC, hence an index of both cells could produce a monitoring tool.	Superoxides	166-176	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
32315368-2	2020	The platelet, one of the main activators of neutrophils, contains Interleukin 8 (IL-8), a potent neutrophil chemo-attractant and P-selectin that induces excretion of superoxide in the neutrophils, forming platelet-neutrophil aggregates that are increased in individuals with active UC, hence an index of both cells could produce a monitoring tool.	Superoxides	166-176	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
32316988-5	2020	RESULTS: Exposure to both Si10 and Min-U-Sil induced gene expression and release of CXCL8, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), interleukin-1alpha (IL-1alpha) and interleukin-1beta (IL-1beta) in a concentration-dependent manner.	si10	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	84-89
33611501-4	2020	METHODS AND RESULTS: After a structured PubMed search, we identified 18F-sodium fluoride (18F-NaF) PET as the most suitable technique for detecting micro-calcification.	18f-sodium fluoride	69-88	C-X-C motif chemokine ligand 8	Homo sapiens	94-97
32022261-7	2020	RESULTS: Treatment with APG-157 resulted in circulating concentrations of curcumin and analogs peaking at 3 hours with reduced IL-1beta, IL-6, and IL-8 concentrations in the salivary supernatant fluid of patients with cancer.	apg	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
32316237-1	2020	This study measures the total graft of 18F-sodium fluoride (NaF) uptake in non-instrumented posterolateral lumbar fusion (niPLF) patients one month after surgery and correlates it with the difference in the clinical findings between the baseline and one year after surgery.	18f-sodium fluoride	39-58	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
32015100-3	2020	In the present report, we present clear evidence that these senescence-related active fibroblasts can dedifferentiate proliferating primary human luminal cells to multipotent stem cells in an interleukin-8 (IL-8)-dependent manner.	Phenobarbital	146-153	C-X-C motif chemokine ligand 8	Homo sapiens	192-205
32419980-1	2020	The goal of this study was to assess pulmonary artery calcification in healthy controls and subjects with suspicion of stable angina pectoris through the usage of quantitative 18F-sodium fluoride positron emission tomography/computed tomography (NaF-PET/CT).	18f-sodium fluoride	176-195	C-X-C motif chemokine ligand 8	Homo sapiens	246-249
32419980-8	2020	For global SUVmean (0.79 compared to 0.58), global TBRmean (1.15 compared to 0.93), and global SUVmax (1.78 compared to 1.60), the NaF uptake was significantly higher in the at-risk patients compared to the controls (all P<0.05).	tbrmean	51-58	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
32326546-6	2020	Among patients with CF, IL-6 and IL-8 were significantly higher in patients with NTH, while TNF-alpha was significantly lower in patients with NP.	SUCCINIC ACID MONO-(13-METHYL-3-OXO-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL) ESTER	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
32015100-3	2020	In the present report, we present clear evidence that these senescence-related active fibroblasts can dedifferentiate proliferating primary human luminal cells to multipotent stem cells in an interleukin-8 (IL-8)-dependent manner.	Phenobarbital	146-153	C-X-C motif chemokine ligand 8	Homo sapiens	207-211
32015100-5	2020	This IL-8-related dedifferentiation of luminal cells was mediated through the STAT3-dependent downregulation of p16INK4A and the microRNA miR-141.	Phenobarbital	39-46	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
31525453-9	2020	CONCLUSION: Infection of cervicovaginal epithelial cells by U. urealyticum stimulates production of ammonia from urea and induces elevated IL-8 production possibly leading to significantly higher cytotoxicity.	Urea	63-67	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
32271889-13	2020	Cis-UCA decreased the release of IL-6, IL-8, and LDH in a time-dependent manner when administered to HCE-2 cells after UV-B exposure.	cis-Urocanic acid	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
32271889-15	2020	Cis-UCA can prevent the secretion of IL-1beta and IL-18 and therapeutically reduces the levels of IL-6, IL-8, and LDH in UV-B-stressed HCE cells.	cis-Urocanic acid	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
32055907-3	2020	In principle, target IL-8 is first treated with the reducing agent tris(2-carboxyethyl)phosphine (TCEP) to yield active thiols and then captured by antibody-functionalized magnetic beads (MBs).	tris(2-carboxyethyl)phosphine	67-96	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
32150447-3	2020	We found that a single treatment with 50 microM cisplatin induces hepatitis A virus cellular receptor 1 (HAVCR1) and C-X-C motif chemokine ligand 8 (CXCL8) expression, DNA damage (gammaH2AX), and cell death in the organoids but greatly impairs organoid viability.	Cisplatin	48-57	C-X-C motif chemokine ligand 8	Homo sapiens	117-147
32150447-3	2020	We found that a single treatment with 50 microM cisplatin induces hepatitis A virus cellular receptor 1 (HAVCR1) and C-X-C motif chemokine ligand 8 (CXCL8) expression, DNA damage (gammaH2AX), and cell death in the organoids but greatly impairs organoid viability.	Cisplatin	48-57	C-X-C motif chemokine ligand 8	Homo sapiens	149-154
32055907-3	2020	In principle, target IL-8 is first treated with the reducing agent tris(2-carboxyethyl)phosphine (TCEP) to yield active thiols and then captured by antibody-functionalized magnetic beads (MBs).	tris(2-carboxyethyl)phosphine	98-102	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
32055907-3	2020	In principle, target IL-8 is first treated with the reducing agent tris(2-carboxyethyl)phosphine (TCEP) to yield active thiols and then captured by antibody-functionalized magnetic beads (MBs).	Sulfhydryl Compounds	120-126	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
32070866-7	2020	Palmitate also induced apoptosis and mRNA expression of IL-6 and IL-8 in the PDLSCs.	Palmitates	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
29948889-1	2020	We investigated the impact of reconstruction parameters and cardiac motion-correction in 18F Sodium Fluoride (18F-NaF) PET.	Sodium Fluoride	93-108	C-X-C motif chemokine ligand 8	Homo sapiens	114-117
31270902-1	2020	The aim of this study was to assess the influence of ketorolac tromethamine and dexamethasone on substance P and IL-8 expression when used as a root canal irrigant for single visit root canal treatment for acute irreversible pulpitis.	Ketorolac Tromethamine	53-75	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
31270902-1	2020	The aim of this study was to assess the influence of ketorolac tromethamine and dexamethasone on substance P and IL-8 expression when used as a root canal irrigant for single visit root canal treatment for acute irreversible pulpitis.	Dexamethasone	80-93	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
31270902-8	2020	The sodium hypochlorite group had a higher mean expression of substance P and IL-8 values.	Sodium Hypochlorite	4-23	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
31479623-6	2020	Chromosome conformation capture (3C) analysis demonstrated the strengthening or loss of specific long-range chromatin interactions in response to rapamycin and quiescence induction, including a cluster of genes containing Interleukin-8 and several chemokine genes on chromosome 4.	Sirolimus	146-155	C-X-C motif chemokine ligand 8	Homo sapiens	222-235
32047095-6	2020	We also found suggestive cross-associated loci for neonatal and maternal vitamin D near immune genes, such as CXCL6-IL8 and ACKR1 We found no interactions with ASD.	Vitamin D	73-82	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
32041439-10	2020	Sulforaphane significantly inhibited the levels of inflammatory mediators including TSLP, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in a dose-dependent manner.	sulforaphane	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
31773440-6	2020	Results disclosed that ar-turmerone dose-dependently suppressed proliferation, facilitated apoptosis, and reduced TNF-alpha-mediated production of interleukin (IL)-1beta, IL-6, and IL-8 in HaCaT cells.	ar-turmerone	23-35	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
31974519-4	2020	The production of interleukin (IL)-6 and IL-8 by human epidermal keratinocytes stimulated by heat-killed Cutibacterium acnes was significantly inhibited by ozenoxacin at concentrations from 1 to 30 mug ml-1.	ozenoxacin	156-166	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
31974519-5	2020	Likewise, the production of IL-6, IL-8, and tumor necrosis factor alpha by stimulated THP-1 cells, a human monocyte cell line, was inhibited by ozenoxacin at concentrations from 1 to 30 mug ml-1.	ozenoxacin	144-154	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
31950542-3	2020	Pre-exposure of 1.5% isoflurane for 0.5 h induced anti-inflammatory effects (measured by cytokine production of TNF-alpha, IL-8, and IL-1beta) in both human THP-1 cells and primary human peripheral blood monocytes stimulated by lipopolysaccharide.	Isoflurane	21-31	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
31691303-11	2020	CONCLUSIONS: NaF and NaOCl solutions were able to electrochemically dissolve PTU F1 and WOGS instruments.	Propylthiouracil	77-80	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
31782556-5	2020	The dextran sulfate plasma adsorption system reduced IFN-gamma, IL-8, IL-1ra, eotaxin, TNF, MCP-1, PDGF-BB, MIP-1beta, and IP-10 (P &lt; .05).	Sulfates	12-19	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
31935586-2	2020	Ag nanoparticles were employed in freestanding and binder-free F-GNS electrode (the composite film electrode was labeled as FGA) as catalyst, which were shown to strongly facilitate the decomposition of NaF during charge process in sodium/carbon fluorides (Na/CFx) secondary batteries.	Sodium	232-238	C-X-C motif chemokine ligand 8	Homo sapiens	203-206
31935586-2	2020	Ag nanoparticles were employed in freestanding and binder-free F-GNS electrode (the composite film electrode was labeled as FGA) as catalyst, which were shown to strongly facilitate the decomposition of NaF during charge process in sodium/carbon fluorides (Na/CFx) secondary batteries.	Carbon	239-255	C-X-C motif chemokine ligand 8	Homo sapiens	203-206
31202739-8	2020	The predictive value of both 18F-FDG (cut-off TBRmax value of 1.98) and 18F-NaF (cut-off TBRmax value of 2.11) uptake demonstrated excellent discrimination in predicting 1-year restenosis (Kaplan Meier estimator, log-rank p < 0.001).	tbrmax	89-95	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
32885098-7	2020	Both 15% Ag-SiO2 and CuO exposure produced significantly higher levels of IL-8 in the co-culture compared with A549 cells alone.	Silicon Dioxide	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
30961342-11	2020	After conventional therapy, levels of IL-6 (P=0.001) and IL-8 (P=0.001) significantly decreased in caffeine citrate prevention group compared with those in caffeine citrate treatment group.	caffeine citrate	99-115	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
32308752-9	2020	Results: Both in vivo and in vitro experiments showed that sodium fluoride (NaF) caused mitochondrial dysfunction and impaired mitochondrial biogenesis.	Sodium Fluoride	59-74	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
31954196-6	2020	Furthermore, the levels of IL-6 and IL-8 showed a stronger correlation with corneal fluorescein staining (CFS) (P&lt;0.05), and the levels of IL-6 and ICAM-1 were most consistent with fluorescein tear film break-up time (TBUT) (P&lt;0.05).	Fluorescein	84-95	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
31893611-0	2020	Methyl linderone suppresses TPA-stimulated IL-8 and MMP-9 expression via the ERK/STAT3 pathway in MCF-7 breast cancer cells.	linderone A	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
31893611-0	2020	Methyl linderone suppresses TPA-stimulated IL-8 and MMP-9 expression via the ERK/STAT3 pathway in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
31893611-6	2020	Moreover, it inhibited two metastasis-related factors, matrix metalloproteinase-9 (MMP-9) and interleukin-8 (IL-8), at the mRNA and protein expression levels, in TPA-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	162-165	C-X-C motif chemokine ligand 8	Homo sapiens	94-107
31893611-6	2020	Moreover, it inhibited two metastasis-related factors, matrix metalloproteinase-9 (MMP-9) and interleukin-8 (IL-8), at the mRNA and protein expression levels, in TPA-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	162-165	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
32292492-7	2020	Methylprednisolone group, compared to Cytosorb and Control had significantly lower levels of TNF-alpha (until the end of surgery, p < 0.001), IL-6 (until 48 h after surgery, p < 0.001), and IL-8 (until 24 h after surgery, p < 0.016).	Methylprednisolone	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
32218354-5	2020	Vildagliptin is able to limit inflammation by suppression of the NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling pathway and proinflammatory agents such as TNF-alpha (tumor necrosis factor alpha), IL-1beta (Interleukin-1beta), and IL-8 (Interleukin 8).	Vildagliptin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	268-272
32218354-5	2020	Vildagliptin is able to limit inflammation by suppression of the NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling pathway and proinflammatory agents such as TNF-alpha (tumor necrosis factor alpha), IL-1beta (Interleukin-1beta), and IL-8 (Interleukin 8).	Vildagliptin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	274-287
32183324-1	2020	The anodic polarization response of magnesium alloy AZ31 was first characterized during exposure to aerated 0.1 M NaCl solutions with millimolar additions of NaVO3, Na3PO4, Na2HPO4, NaF and various pairings to assess their ability to inhibit corrosion kinetics and retard localized corrosion.	Magnesium	36-45	C-X-C motif chemokine ligand 8	Homo sapiens	182-185
32197426-0	2020	Identification of Interleukin-8-Reducing Lead Compounds Based on SAR Studies on Dihydrochalcone-Related Compounds in Human Gingival Fibroblasts (HGF-1 cells) In Vitro.	dihydrochalcone	80-95	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
32256360-9	2020	The in vitro anti-inflammatory activity was carried out on monosodium urate (MSU) crystal-induced pro-inflammatory cytokines (i.e., interleukin (IL)1alpha, IL-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha) secretion using human peripheral blood mononuclear cells and ELISA technique, and prostaglandin E2 (PGE2)secretion using radioimmunoassay.	Uric Acid	59-75	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
32256360-9	2020	The in vitro anti-inflammatory activity was carried out on monosodium urate (MSU) crystal-induced pro-inflammatory cytokines (i.e., interleukin (IL)1alpha, IL-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha) secretion using human peripheral blood mononuclear cells and ELISA technique, and prostaglandin E2 (PGE2)secretion using radioimmunoassay.	Uric Acid	77-80	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
32185685-7	2021	Higher CT calcium mass, total cholesterol, and HbA1c were associated with higher 18F-NaF TBR after adjusting.	Calcium	10-17	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
32185685-8	2021	CONCLUSION: This study shows that several modifiable cardiovascular risk factors (total cholesterol, triglycerides, HbA1c) are associated with femoral 18F-NaF tracer uptake in patients with type 2 diabetes.	Cholesterol	88-99	C-X-C motif chemokine ligand 8	Homo sapiens	155-158
32185685-8	2021	CONCLUSION: This study shows that several modifiable cardiovascular risk factors (total cholesterol, triglycerides, HbA1c) are associated with femoral 18F-NaF tracer uptake in patients with type 2 diabetes.	Triglycerides	101-114	C-X-C motif chemokine ligand 8	Homo sapiens	155-158
32192002-4	2020	According to our knowledge, the present study is the first to evaluate the clinical usefulness of serum CXCL-8 (C-X-C motif chemokine 8) in the diagnosis and progression of CRC compared to classical tumor marker CEA (carcinoembryonic antigen) and marker of inflammation CRP (C-reactive protein).	c-x-c	112-117	C-X-C motif chemokine ligand 8	Homo sapiens	104-110
32226841-4	2020	The results indicated that Na2UF8 on the NaF sorbent was stable under 300  C in the argon atmosphere, and it started to decompose into UF6 and NaF rapidly when the temperature was above 300  C. Meanwhile, a small amount of Na2UF8 was converted to Na3UF7, and it was stable in the temperature range from 350 to 450  C. The decomposition mechanism of the Na2UF8 and the formation mechanism of Na3UF7 on the NaF sorbent were speculated according to the experimental results.	na2uf8	27-33	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
32226841-4	2020	The results indicated that Na2UF8 on the NaF sorbent was stable under 300  C in the argon atmosphere, and it started to decompose into UF6 and NaF rapidly when the temperature was above 300  C. Meanwhile, a small amount of Na2UF8 was converted to Na3UF7, and it was stable in the temperature range from 350 to 450  C. The decomposition mechanism of the Na2UF8 and the formation mechanism of Na3UF7 on the NaF sorbent were speculated according to the experimental results.	na2uf8	27-33	C-X-C motif chemokine ligand 8	Homo sapiens	143-146
32226841-4	2020	The results indicated that Na2UF8 on the NaF sorbent was stable under 300  C in the argon atmosphere, and it started to decompose into UF6 and NaF rapidly when the temperature was above 300  C. Meanwhile, a small amount of Na2UF8 was converted to Na3UF7, and it was stable in the temperature range from 350 to 450  C. The decomposition mechanism of the Na2UF8 and the formation mechanism of Na3UF7 on the NaF sorbent were speculated according to the experimental results.	na2uf8	27-33	C-X-C motif chemokine ligand 8	Homo sapiens	143-146
32226841-4	2020	The results indicated that Na2UF8 on the NaF sorbent was stable under 300  C in the argon atmosphere, and it started to decompose into UF6 and NaF rapidly when the temperature was above 300  C. Meanwhile, a small amount of Na2UF8 was converted to Na3UF7, and it was stable in the temperature range from 350 to 450  C. The decomposition mechanism of the Na2UF8 and the formation mechanism of Na3UF7 on the NaF sorbent were speculated according to the experimental results.	Argon	84-89	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
32256360-16	2020	In vitro anti-inflammatory assay showed that extract of MPP roots inhibited MSU crystals-induced secretion of IL-1alpha, IL-1beta, IL-8, TNF-alpha, and PGE2 with IC50 values of 36, 25, 38, 18, and 46 mug/mL, respectively.	Uric Acid	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
32196098-6	2020	Results: Treatment with noncytotoxic concentrations of GS resulted in the dose-dependent inhibition of IL-1beta-induced inflammatory cytokines, including IL-6, IL-8, MCP-1, and COX-2, at both mRNA and protein levels.	pregna-4,17-diene-3,16-dione	55-57	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
32218789-13	2020	IC87114 decreased poly I:C-induced PD-L1 expression on PBECs and secretion of IL-6 and IL-8 into culture supernatants.	Poly I	18-24	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
32218789-13	2020	IC87114 decreased poly I:C-induced PD-L1 expression on PBECs and secretion of IL-6 and IL-8 into culture supernatants.	Carbon	1-2	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
32064872-4	2020	In porcine intestinal epithelial cells (IPEC-J2), L-arginine obviously suppressed (p &lt; 0.05) the levels of IL-6 (220.63 +- 2.82), IL-8 (333.95 +- 3.75), IL-1beta (693.08 +- 2.38) and TNF-alpha (258.04 +- 4.14) induced by LPS.	Arginine	50-60	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
32150886-7	2020	The release of IL-1beta, IL-8, MCP-1 and M-CSF proteins was mainly affected in macrophages after metal ion exposure (100 microM), indicating a higher impact on pro-inflammatory activity.	Metals	97-102	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
32210955-8	2020	Concentrations of VCAM-1, intercellular adhesion molecule-1 (ICAM-1), and IL-8 strongly correlated with total heme levels in CSF.	Heme	110-114	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
32139669-4	2020	In vitro, both knockdown of TRPC6 expression with shRNA and TRPC6 blockage markedly attenuated the release of cytokines IL-6 and IL-8 induced by O3 or H2O2 in 16HBE cells (human bronchial epithelial cell line).	Ozone	145-147	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
32139669-4	2020	In vitro, both knockdown of TRPC6 expression with shRNA and TRPC6 blockage markedly attenuated the release of cytokines IL-6 and IL-8 induced by O3 or H2O2 in 16HBE cells (human bronchial epithelial cell line).	Hydrogen Peroxide	151-155	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
32139808-0	2021	Hippocampal TNF-death receptors, caspase cell death cascades, and IL-8 in alcohol use disorder.	Alcohols	74-81	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
32065293-9	2020	Notably, DON-induced interleukin-8 transcription and secretion were diminished by the presence of 10 and 25 ng/mL CER after short-term (5 h) incubation, indicating immunosuppressive properties.	deoxynivalenol	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	21-34
32135490-8	2020	Pristimerin dramatically inhibited the expression of TNF-alpha-induced endothelial adhesion molecules (intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1)) and the pro-inflammatory cytokine (IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1)).	pristimerin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	235-239
31486595-8	2020	RESULTS: Tear levels of IL-8 were significantly increased in patients with oMMP (260.1 +- 70 pg/ml) when compared to both HCs (98.5 +- 71.35 pg/ml; p = 0.001) and patients with pSS (96.3 +- 87.5 pg/ml; p = 0.001).	ommp	75-79	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
31486595-8	2020	RESULTS: Tear levels of IL-8 were significantly increased in patients with oMMP (260.1 +- 70 pg/ml) when compared to both HCs (98.5 +- 71.35 pg/ml; p = 0.001) and patients with pSS (96.3 +- 87.5 pg/ml; p = 0.001).	pss	177-180	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
32065293-9	2020	Notably, DON-induced interleukin-8 transcription and secretion were diminished by the presence of 10 and 25 ng/mL CER after short-term (5 h) incubation, indicating immunosuppressive properties.	cereulide	114-117	C-X-C motif chemokine ligand 8	Homo sapiens	21-34
31927406-8	2020	SBU supernatant increased the frequency of monocytes expressing IL-8 and decreased the monocytes expressing IL-10.	sbu	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
31927406-9	2020	Considering S. mutans-stimulated cells, while SBU increased the frequency of IL-8+ monocytes, CSEB reduced the frequency of IL-6 and TNF-alpha positive monocytes.	sbu	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
31962250-4	2020	BmV at 50 and 75 microg/mL reduced CXCL8/IL-8 (p < 0.001 and p < 0.01, respectively) and CCL2/MCP-1 production (p < 0.05), while BmooLAAO-I at the same concentrations reduced only CCL2/MCP-1 production (p < 0.01).	7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	35-40
32113050-1	2020	BACKGROUND AND AIMS: Molecular imaging with 18Fluorodeoxyglucose (FDG) and 18F-sodium-fluoride (NaF) captures arterial inflammation and micro-calcification and can reveal potentially unstable atherosclerotic plaques.	18f-sodium-fluoride	75-94	C-X-C motif chemokine ligand 8	Homo sapiens	96-99
31327083-8	2020	DOXY group exhibited a significant increase in the levels of anti-inflammatory interleukin (IL)-10 and a reduction in IL-8, IFN-y, IL-6, and IL-17 (p &lt; 0.05), significant reduction in periodontal pathogens (p &lt; 0.05), and a lower mean percentage of HbA1C at 3 months (p &lt; 0.05).	Doxycycline	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
31758423-9	2020	IGU, MTX, and DXM dose dependently decreased the secretion of TNF-alpha, IL-1beta, IL-6, and IL-8 in neutrophils and PBMCs (P &lt; 0.05); the inhibitory effect of IGU was not significantly different from that of MTX and DXM.	Methotrexate	5-8	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
31758423-9	2020	IGU, MTX, and DXM dose dependently decreased the secretion of TNF-alpha, IL-1beta, IL-6, and IL-8 in neutrophils and PBMCs (P &lt; 0.05); the inhibitory effect of IGU was not significantly different from that of MTX and DXM.	Dexamethasone	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
31754794-0	2020	18F-Fluoride (18F-NaF) PET/CT in medullary thyroid carcinoma: far from evidence, far from guidelines!	Fluorides	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
31754794-0	2020	18F-Fluoride (18F-NaF) PET/CT in medullary thyroid carcinoma: far from evidence, far from guidelines!	CP-18 compound	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
32015511-7	2020	Nintedanib greatly reduced the levels of cancer-promoting cytokines, such as interleukin (IL)-6 (IL-6) and IL-8, secreted by CAFs.	nintedanib	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
32556016-8	2020	However, when analyzing the TSL, it was observed that Ca2+-MSNs, TiF4, and NaF were more effective in preventing dental erosion versus CPP-ACP, CPP-ACP/F-, and Milli-Q  water (p< 0.05).	Water	169-174	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
32164454-3	2020	This study investigates (1) 18F-fluorodeoxyglucose (FDG) and 18F-sodium fluoride (NaF) uptake in culprit versus nonculprit carotid atheroma, (2) spatial distributions of uptake, and (3) how macrocalcification affects this relationship.	18f-sodium fluoride	61-80	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
31972422-5	2020	The following proteins were found to occur in both RA-associated networks and triptolide target networks: CD274, RELA, MCL1, MAPK8, CXCL8, STAT1, STAT3, c-JUN, JNK, c-Fos, NF-kappaB, and TNF-alpha.	triptolide	78-88	C-X-C motif chemokine ligand 8	Homo sapiens	132-137
31972422-6	2020	Docking studies suggested that triptolide can fit in the binding pocket of the six top candidate triptolide target proteins (CD274, RELA, MCL1, MAPK8, CXCL8 and STAT1).	triptolide	31-41	C-X-C motif chemokine ligand 8	Homo sapiens	151-156
31972422-6	2020	Docking studies suggested that triptolide can fit in the binding pocket of the six top candidate triptolide target proteins (CD274, RELA, MCL1, MAPK8, CXCL8 and STAT1).	triptolide	97-107	C-X-C motif chemokine ligand 8	Homo sapiens	151-156
31962250-4	2020	BmV at 50 and 75 microg/mL reduced CXCL8/IL-8 (p < 0.001 and p < 0.01, respectively) and CCL2/MCP-1 production (p < 0.05), while BmooLAAO-I at the same concentrations reduced only CCL2/MCP-1 production (p < 0.01).	7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
32274105-8	2020	Also, Sch A downregulated the expression of IL-8 and upregulated the expression of HO-1 mRNA in lung epithelial cells and cell supernatants, and resulted in the downregulation of the protein expression level of phosphorylated nuclear factor-kappaB.	schizandrin A	6-11	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
31811067-4	2020	Though 18F-sodium fluoride (18F-NaF) was one of the oldest medical tracers but was replaced by other tracers until recently, owing to its physical properties.	Sodium Fluoride	7-26	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
31811067-4	2020	Though 18F-sodium fluoride (18F-NaF) was one of the oldest medical tracers but was replaced by other tracers until recently, owing to its physical properties.	CP-18 compound	7-10	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
31811067-5	2020	Continued development of positron emission tomographic (PET) scanners have opened a new era for 18F-NaF and given its higher sensitivity, there have been increasing applications in imaging.	CP-18 compound	96-99	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
31811067-7	2020	Finally, we compared the accuracy of 18F-NaF PET with other conventional imaging for detection of osseous metastasis.	CP-18 compound	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
31899823-16	2020	Patients with a detectable PSA after ADT had elevated levels of IL-6 (P = .049) and IL-8 (P = .013) at PSA progression as compared with those with an undetectable PSA.	adt	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
31904489-11	2020	An increase in IL-8 during the 6 weeks of KJD was associated with significantly greater improvement in KOOS4 over 12 months.	koos4	103-108	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
31927915-9	2020	Finally, we performed functional secretory analysis of interleukin-8 and tumor necrosis factor alpha from human neutrophils and monocytes, stimulated with various doses of lipopolysaccharide and phorbol 12-myristate 13-acetate-ionomycin, respectively.	phorbol 12-myristate 13-acetate-ionomycin	195-236	C-X-C motif chemokine ligand 8	Homo sapiens	55-68
32101144-7	2020	Large agglomerates of 17 nm TiO2 induced stronger responses than small agglomerates for glutathione depletion, IL-8 and IL-1beta increase, and DNA damage in THP-1, while no effect of agglomeration was observed with 117 nm TiO2.	titanium dioxide	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
32112175-9	2020	In vitro, the PI3K inhibitors (BZE235 and LY294002) ameliorated GC insensitivity in H2O2/TNFalpha-induced IL-8 release from U937 cells by independently restoring the activity of HDAC2 or inhibiting the activation of transcription factors.	bze235	31-37	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
32112175-9	2020	In vitro, the PI3K inhibitors (BZE235 and LY294002) ameliorated GC insensitivity in H2O2/TNFalpha-induced IL-8 release from U937 cells by independently restoring the activity of HDAC2 or inhibiting the activation of transcription factors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
32112175-9	2020	In vitro, the PI3K inhibitors (BZE235 and LY294002) ameliorated GC insensitivity in H2O2/TNFalpha-induced IL-8 release from U937 cells by independently restoring the activity of HDAC2 or inhibiting the activation of transcription factors.	Hydrogen Peroxide	84-88	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
32120344-6	2020	Of interest, we observed that 1alpha,25(OH)2D3 inhibits NF-kappaB activation and subsequent synthesis and secretion of IL-6 and IL-8 by promoting VDR and NF-kappaB p65 interaction.	25(oh)2d3	37-46	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
32211217-9	2020	A preliminary study has shown that [99m Tc]-labelled IL8 may be a possible candidate for imaging of peripheral OM.	Technetium	40-42	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
32211218-4	2020	In this study, we aimed to assess 18F-sodium fluoride (18F-NaF) uptake by the aortic valve on PET/CT scans performed in two age groups; 25-35 and 50-75 years of age.	18f-sodium fluoride	34-53	C-X-C motif chemokine ligand 8	Homo sapiens	59-62
31843963-7	2020	Moreover, IpaJ was efficient in the prevention of NF-kappaB translocation to the nucleus and ultimately interfered with the secretion of the proinflammatory cytokines IL-1beta, IL-6, and IL-8 in infected HeLa cells.	ipaj	10-14	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
33005593-3	2020	Here, we investigated whether sodium fluoride (NaF) has the ability to induce DNA damage and chromosomal abnormalities in human osteosarcoma cells after 48 and 72 h of exposure.	Sodium Fluoride	30-45	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
31912731-2	2020	Chemical bath deposited (CBD) CdS layers of different thickness on NaF PDT (CIGSeNaF) and on NaF+KF PDT (CIGSeNaF+KF) Cu(In,Ga)Se2 absorbers prepared at low temperature (to facilitate the use of flexible, e.g. polyimide, substrates) were studied.	Cadmium	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
32057253-3	2020	The levels of cytokine and chemokine were analysed with ELISA and real-time PCR.Results: Astragaloside IV significantly inhibited the levels of CCL5, MCP-1, IL-6 and IL-8.	astragaloside A	89-102	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
32104118-9	2020	Multiple linear regression analyses led to the identification of ArI (beta=0.026, P&lt;0.05) and TST (beta=-0.054, P&lt;0.05) as significant positive and negative predictors of the IL-8 level, respectively.	BAL-ARI8	65-68	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
31863766-5	2020	In this study, we found that rapamycin (an mTOR inhibitor) and p70S6K siRNA diminished thrombin-induced IL-8/CXCL8 release.	Sirolimus	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
32075981-9	2020	Celecoxib was responsible for only 5% of the variance in bacterial community composition but celecoxib-exposed microbiota preserved barrier function and decreased concentrations of IL-8 and CXCL16 in a donor-dependent manner in our two models simulating gut inflammatory milieu.	celecoxib	93-102	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
32079388-6	2020	Sodium fluoride (NaF) PET/CT is a promising imaging modality in evaluation of skeletal system.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
32296583-12	2020	Subsequently, IL-8 recruited neutrophils which in turn mediated NETs formation via the PI3K/AKT/ROS axis in TINs.	ros	96-99	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
32296583-12	2020	Subsequently, IL-8 recruited neutrophils which in turn mediated NETs formation via the PI3K/AKT/ROS axis in TINs.	tins	108-112	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
32296583-13	2020	Conclusions: Our results suggest that NETs produced by TINs mediate the crosstalk between glioma progression and the tumor microenvironment by regulating the HMGB1/RAGE/IL-8 axis.	tins	55-59	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
32075287-11	2020	The use of curcumin reduces the subjective perception of the intensity of muscle pain; reduces muscle damage through the decrease of creatine kinase (CK); increases muscle performance; has an anti-inflammatory effect by modulating the pro-inflammatory cytokines, such as TNF-alpha, IL-6, and IL-8; and may have a slight antioxidant effect.	Curcumin	11-19	C-X-C motif chemokine ligand 8	Homo sapiens	292-296
32117213-6	2019	The relative expression and secretion of IL-6, IL-8, and TNF-alpha in lipopolysaccharide-stimulated microglia were up-regulated in the GSC supernatant group, which could be reversed by dimethyl amiloride (DMA) (EV secretion inhibitor) co-administration or si-MALAT1 pre-transfection of GSCs.	5-dimethylamiloride	185-203	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
32117213-6	2019	The relative expression and secretion of IL-6, IL-8, and TNF-alpha in lipopolysaccharide-stimulated microglia were up-regulated in the GSC supernatant group, which could be reversed by dimethyl amiloride (DMA) (EV secretion inhibitor) co-administration or si-MALAT1 pre-transfection of GSCs.	5-dimethylamiloride	205-208	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
31863766-5	2020	In this study, we found that rapamycin (an mTOR inhibitor) and p70S6K siRNA diminished thrombin-induced IL-8/CXCL8 release.	Sirolimus	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	109-114
32010486-6	2020	Upon adding sMICA, the release of cytokines IFN-gamma, TNF-alpha, and IL-8 by NK cell line (NKL) under stimulation of immobilized rMICA was blocked.	MHC class I-related chain A	130-135	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
31629806-3	2020	Modulation of basal level and poly(I:C)-induced IL-8 secretion varied between bacterial species, and between heat treated and non-heat treated bacterial cells.	Poly I-C	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
31887433-8	2020	The mRNA expression of IL-6, IL-8 and PTGS2 in HT-29 cells decreased by more than 60% upon incubation with CD + SPM138 co-cultures as compared to the levels observed after treatment with CD supernatant only.	cd +	107-111	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
31887433-9	2020	The concentration of IL-8 also decreased by more than 60% upon treatment with CD + SPM138 co-culture supernatant.	cd +	78-82	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
31498191-10	2020	RESULTS: Ropivacaine exposure dose-dependently induced apoptosis and an increased release of IL-6, IL-8, and PGE2 from HUVECs and TBs.	Ropivacaine	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
31887433-9	2020	The concentration of IL-8 also decreased by more than 60% upon treatment with CD + SPM138 co-culture supernatant.	spm138	83-89	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
31498191-14	2020	Conversely, lidocaine exhibited repression of IL-6 and IL-8 release over all time points, and early downregulation of COX2 and cell adhesion molecules, which was followed by a late overshooting reaction.	Lidocaine	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
32024069-0	2020	Nicotine Induces IL-8 Secretion from Pancreatic Cancer Stroma and Worsens Cancer-Induced Cachexia.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
31855746-6	2020	RESULTS: rDPP dose-dependently reduced the expression of lipopolysaccharide-induced inflammatory genes, such as TNFalpha, IL-1beta, and IL-8, and TNF-alpha protein secretion from the macrophages.	rdpp	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
31735734-0	2020	Benzoylaconitine inhibits production of IL-6 and IL-8 via MAPK, Akt, NF-kappaB signaling in IL-1beta-induced human synovial cells.	benzoylaconine	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
31735734-2	2020	In this study, the effects and mechanisms of BAC on production of inflammatory cytokines interleukin (IL)-6 and IL-8 were investigated in IL-1beta-stimulated human synovial SW982 cells.	4-deoxyneosamine C	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
31735734-4	2020	The results revealed that BAC suppressed gene and protein expression of IL-6 and IL-8 induced by IL-1beta.	4-deoxyneosamine C	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
31619441-8	2020	However, in the intervention but not the control group, change in urinary PG as a marker of e-cig use and inhalation, was significantly correlated with change in cell counts (cell concentrations, macrophages, and lymphocytes) and cytokines (IL-8, IL-13, and TNF-alpha), although the absolute magnitude of changes was small.	Propylene Glycol	74-76	C-X-C motif chemokine ligand 8	Homo sapiens	241-245
31622892-6	2020	PBDEs (47, 99 and 209) exposure decreased TEER, ZO-1 and pH values, and increased IL-8, Muc5AC, Muc5B (mRNAs and proteins), NOX-4 (mRNA), and rheological parameters (G", G"") in ALI cultures of A549 cell line and pHBEC.	Halogenated Diphenyl Ethers	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
31769560-9	2020	Pretreatment with BAY 11-7082 significantly inhibited vibration-induced IL-6 and IL-8 mRNA and protein expression in hPDL cells.	3-(4-methylphenylsulfonyl)-2-propenenitrile	18-29	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
32024069-6	2020	Nicotine induced secretion of interleukin 8 (IL-8) by tumor-associated stroma cells in an extracellular signal-regulated kinase (ERK)-dependent fashion.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
32024069-6	2020	Nicotine induced secretion of interleukin 8 (IL-8) by tumor-associated stroma cells in an extracellular signal-regulated kinase (ERK)-dependent fashion.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
31898754-11	2020	However, only IL-8 significantly increased after adding LPS or Poly (I:C) to the AT-MSC media.	poly If	63-67	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
31821660-10	2020	Extracellular ATP stimulates the secretion of IL8 from epithelial cells to promote the process of in vitro decidualization.	Adenosine Triphosphate	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
31634687-4	2020	H295R cells stimulated with either interleukin-1beta (IL-1beta) or phorbol ester also showed elevated IL-8 mRNA levels and higher IL-8 promoter activities.	Phorbol Esters	67-80	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
31634687-4	2020	H295R cells stimulated with either interleukin-1beta (IL-1beta) or phorbol ester also showed elevated IL-8 mRNA levels and higher IL-8 promoter activities.	Phorbol Esters	67-80	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
31634687-7	2020	Upregulation of IL-8 expression in IL-1beta-treated H295R cells required NF-kappaB while the phorbol ester TPA used both the AP-1 and NF-kappaB sites of the IL-8 gene to stimulate IL-8 expression.	Phorbol Esters	93-110	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
31631328-6	2020	Moreover, it was observed that nicotine decreases the production of interleukin (IL)-6 and C-C chemokine ligand (CCL)5 during Mtb infection in epithelial cells (EpCs), whereas in macrophages derived from human monocytes (MDMs) there is a decrease in IL-8, IL-6, tumor necrosis factor (TNF)-alpha, IL-10, CCL2, C-X-C chemokine ligand (CXCL)9 and CXCL10 only during infection with Mtb.	Nicotine	31-39	C-X-C motif chemokine ligand 8	Homo sapiens	250-254
31372914-6	2020	While conventional amphotericin B further increased IL-6 and to a smaller extent IL-8 levels, this was not the case for its liposomal formulation.	Amphotericin B	19-33	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
32080341-10	2020	Pharmacological inhibition of PAP1 with propranolol suppressed UVB-induced production of IL-6 and IL-8 in NHEKs and reconstituted human skin models.	Propranolol	40-51	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
31634687-7	2020	Upregulation of IL-8 expression in IL-1beta-treated H295R cells required NF-kappaB while the phorbol ester TPA used both the AP-1 and NF-kappaB sites of the IL-8 gene to stimulate IL-8 expression.	Phorbol Esters	93-110	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
31806428-4	2020	RESULTS: In multivariable regression urinary Il-1 alpha correlated positively with podocalyxin and NAG (p &lt; 0.0001, R2= 0.57); urinary IL-8 correlated directly with synaptopodin, NAG, nephrin, and KIM-1 (p &lt; 0.0001, R2 = 0.67); urinary IL-18 correlated directly with synaptopodin, NAG, and nephrin (p &lt; 0.0001, R2 = 0.59).	synaptopodin	168-180	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
31135098-6	2020	We also assessed the production of inflammatory factors interleukin-8 and chemokine ligand-2 induced by benzo(a)pyrene exposure at both mRNA and protein levels.	Benzo(a)pyrene	104-118	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
31806428-5	2020	Serum IL-1 alpha correlated positively with nephrin, synaptopodin, NAG (P &lt; 0.0001, R2 = 0.68); serum IL-8 correlated directly with synaptopodin and NAG (p &lt; 0.0001, R2 = 0.66); serum IL-18 correlated directly with NAG, KIM-1, and podocalyxin (p &lt; 0.0001, R2=0.647).	synaptopodin	135-147	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
31475386-6	2020	The proline mutation in the TMD of beta2 completely inhibited arrest of rolling HL-60 cells in response to the chemokine IL-8.	Proline	4-11	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
31383073-1	2020	N and F co-doped La-TiO2 (La-TONF) samples were prepared through the solvothermal method by using HMT and NaF as precursors.	la-tio2	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	106-109
32554850-10	2020	Pretreatment of A-T cells with alpha-LA inhibited IL-1beta-induced activation of NF-kappaB, IL-8 expression, and mitochondrial dysfunction by reducing ROS levels.	Thioctic Acid	31-39	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
32554850-0	2020	Inhibitory effect of alpha-lipoic acid on mitochondrial dysfunction and interleukin-8 expression in interleukin-1beta-stimulated ataxia teleangiectasia fibroblasts.	Thioctic Acid	21-38	C-X-C motif chemokine ligand 8	Homo sapiens	72-85
32554850-4	2020	ROS are related to mitochondrial dysfunction and activation of nuclear factor kappa B (NF-kappaB) to induce IL-8 expression.	Reactive Oxygen Species	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
31347162-0	2020	CD73-dependent adenosine dampens interleukin 1beta-induced CXCL8 production in gingival fibroblasts: Association with heme oxygenase-1 and adenosine monophosphate-activated protein kinase.	Adenosine	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	59-64
31347162-3	2020	Here, we investigated whether CD73-mediated hydrolysis of extracellular ATP (eATP) could affect interleukin (IL)-1beta-induced CXCL8 secretion.	Adenosine Triphosphate	72-75	C-X-C motif chemokine ligand 8	Homo sapiens	127-132
31347162-7	2020	The effect of eATP degradation to adenosine on CXCL8 levels was investigated using agonist and antagonist of adenosine receptors.	Adenosine	34-43	C-X-C motif chemokine ligand 8	Homo sapiens	47-52
31347162-9	2020	ATP pretreatment impaired IL-1beta-induced CXCL8 secretion and required activation of heme oxygenase-1 (HO-1) and phosphorylated adenosine monophosphate-activated protein kinase (pAMPK).	Adenosine Triphosphate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	43-48
31347162-10	2020	The inhibition of CD73 or the inhibition of adenosine receptors abrogated the ATP effect on CXCL8 secretion.	Adenosine Triphosphate	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	92-97
31347162-11	2020	CONCLUSIONS: CD73-generated adenosine dampens IL-1beta-induced CXCL8 in HGFs and involves HO-1 and pAMPK signaling.	Adenosine	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	63-68
32554850-6	2020	This study is aimed to determine if alpha-LA confers protection against NF-kappaB activation, IL-8 expression, and mitochondrial dysfunction in A-T cells which are exposed to the inflammatory cytokine IL-1beta.	Thioctic Acid	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
32554850-11	2020	In conclusion, supplementation with alpha-LA may be beneficial for reducing the oxidative stress-induced mitochondrial dysfunction and IL-8 production associated with A-T.	Thioctic Acid	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
31860524-1	2020	OBJECTIVES: Atherosclerotic plaque molecular imaging with F-sodium fluoride (NaF) PET with computed tomography (PET-CT) may identify active unstable microcalcification.	Sodium Fluoride	58-75	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
32001775-7	2020	ROS-derived 4-hydroxy-2-nonenal induced interleukin IL-8 release from monocytes.	4-hydroxy-2-nonenal	12-31	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
31639410-5	2020	In nitrogen-mustard-exposed cultured immortalized human keratinocytes (HaCaT cells), Fra-1 in the nucleus functioned as an inhibitor of inflammatory cytokine interleukin (IL)-8.	Nitrogen	3-11	C-X-C motif chemokine ligand 8	Homo sapiens	158-176
31757425-7	2020	Moreover, we found that PEPT1 knockdown in differentiated keratinocytes significantly suppressed the influence of a bacterial-derived peptide, muramyl dipeptide (MDP), on the production of proinflammatory cytokine interleukin-8, implying that bacteria-derived oligopeptides can be transported by PEPT1 in advanced differentiated keratinocytes.	Acetylmuramyl-Alanyl-Isoglutamine	143-160	C-X-C motif chemokine ligand 8	Homo sapiens	214-227
31757425-7	2020	Moreover, we found that PEPT1 knockdown in differentiated keratinocytes significantly suppressed the influence of a bacterial-derived peptide, muramyl dipeptide (MDP), on the production of proinflammatory cytokine interleukin-8, implying that bacteria-derived oligopeptides can be transported by PEPT1 in advanced differentiated keratinocytes.	Acetylmuramyl-Alanyl-Isoglutamine	162-165	C-X-C motif chemokine ligand 8	Homo sapiens	214-227
31680128-5	2020	RESULTS: Fipronil treatment increased pro-inflammatory cytokine interleukin (IL)-1beta, IL-6, IL-8, and MUC5AC expression in human primary nasal epithelial cells.	fipronil	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
31680128-9	2020	CONCLUSIONS: Fipronil induced pro-inflammatory cytokine IL-1beta, IL-6, IL-8, and MUC5AC expression via ERK1/2 MAPK, p38 MAPK, and NF-kB in human primary nasal epithelial cells.	fipronil	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
31536757-7	2020	Moderate concentrations of PFOS suppressed release of the chemokines CXCL8 and CXCL10, whereas both PFOS and PFOA stimulated the release of the pro-inflammatory cytokine IL-1beta in immune stimulated human bronchial epithelial cells.	perfluorooctane sulfonic acid	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	69-74
33329788-8	2020	Results: Curcumin attenuated expression of TNF-alpha, IL-6, and IL-8 and the phosphorylation levels of p38 and JNK, but not ERK1/2, in LPS-stimulated neutrophils.	Curcumin	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
31825424-5	2020	They also showed anti-inflammatory potential in tumor necrosis factor (TNF)-alpha-, interleukin (IL)-1beta- and H2O2-stimulated Caco-2 cells by suppressing the secretion of IL-8 and the expression of cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS).	Water	112-116	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
31971958-8	2020	RESULTS: Dolutegravir reduced inflammation by decreasing NFkappaB activation and IL-6/IL-8/sICAM-1/sVCAM-1 secretion, as did maraviroc with a milder effect.	dolutegravir	9-21	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
32025384-10	2020	Cholesterol and magnesium intake exerted enhancing effects on the positive relationship between the relative abundance of Comamonas and IL-8 concentration (p &lt; 0.05).	Cholesterol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
32025384-10	2020	Cholesterol and magnesium intake exerted enhancing effects on the positive relationship between the relative abundance of Comamonas and IL-8 concentration (p &lt; 0.05).	Magnesium	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
31975332-1	2021	BACKGROUND: Microcalcifications cannot be identified with the present resolution of CT; however, 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) imaging has been proposed for non-invasive identification of microcalcification.	Sodium Fluoride	97-116	C-X-C motif chemokine ligand 8	Homo sapiens	122-125
31975332-1	2021	BACKGROUND: Microcalcifications cannot be identified with the present resolution of CT; however, 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) imaging has been proposed for non-invasive identification of microcalcification.	CP-18 compound	97-100	C-X-C motif chemokine ligand 8	Homo sapiens	122-125
31975332-2	2021	The primary objective of this study was to assess whether 18F-NaF activity can assess the presence and predict the progression of CT detectable vascular calcification.	CP-18 compound	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	62-65
31975332-3	2021	METHODS AND RESULTS: The data of two longitudinal studies in which patients received a 18F-NaF PET-CT at baseline and after 6 months or 1-year follow-up were used.	CP-18 compound	87-90	C-X-C motif chemokine ligand 8	Homo sapiens	91-94
31975332-8	2021	CONCLUSION: The activity of 18F-NaF is related to the amount of calcification and calcification progression.	CP-18 compound	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
31886641-3	2020	The optimum amount of FEC (10 vol.%) renders a stable LiF/NaF-rich SEI on Sb electrodes that can suppress the continuous electrolytes decomposition and accommodate the volume variation.	vinyl fluoride	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
31964911-4	2020	In M0 macrophages, cyH induced a pro-inflammatory phenotype characterized by an increase in TNFalpha and IL-8/MIP-2 secretion.	cyclohexanone	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
31886641-3	2020	The optimum amount of FEC (10 vol.%) renders a stable LiF/NaF-rich SEI on Sb electrodes that can suppress the continuous electrolytes decomposition and accommodate the volume variation.	Antimony	74-76	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
31928157-8	2020	Medin induced EC immune activation (increased interleukin-8, interleukin-6, intercellular adhesion molecule-1, and plasminogen activator inhibitor-1) and reduced EC viability, which were reversed by monosialoganglioside-containing nanoliposomes.	sialogangliosides	199-219	C-X-C motif chemokine ligand 8	Homo sapiens	46-59
31960968-9	2020	RESULTS: We report here that UDCA significantly reduced the IL1beta and TNFalpha-induced expression of IL1, IL6 and IL8 in gingival fibroblasts and the HSC-2 cell line.	Ursodeoxycholic Acid	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
31931830-6	2020	From pre- to post-deployment/bTBI, levels of interleukin 8 (IL-8) were decreased among both mild cases (mu = - 83.43 pg/ml; s.e.	btbi	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	45-58
31931830-6	2020	From pre- to post-deployment/bTBI, levels of interleukin 8 (IL-8) were decreased among both mild cases (mu = - 83.43 pg/ml; s.e.	btbi	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
31931830-14	2020	CONCLUSION: The findings of this longitudinal study indicate that in the chronic phase of bTBI, levels of IL-8 and MMP3 may be substantially lower than pre-injury.	btbi	90-94	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
31902928-5	2020	Regarding neutrophilic airway inflammation in steroid-resistant asthma, IL-17 derived from Th17 cells and IL-8 and tumor necrosis factor-alpha derived mainly from macrophages were reported to be involved in the pathogenesis.	Steroids	46-53	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
31825618-5	2020	Meanwhile, 80 muM kaempferol alleviated the drop of TEER, the increase of FITC flux, and the overexpression of interleukin-8 (IL-8) induced by 1 mug/mL lipopolysaccharide (LPS).	kaempferol	18-28	C-X-C motif chemokine ligand 8	Homo sapiens	111-124
31825618-5	2020	Meanwhile, 80 muM kaempferol alleviated the drop of TEER, the increase of FITC flux, and the overexpression of interleukin-8 (IL-8) induced by 1 mug/mL lipopolysaccharide (LPS).	kaempferol	18-28	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
31825618-7	2020	Our results suggest that kaempferol alleviates the IL-8 secretion and barrier dysfunction of the Caco-2 monolayer in the LPS-induced epithelial-endothelial coculture model via inhibiting the NF-kappaB signaling pathway activation.	kaempferol	25-35	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
33176315-1	2020	The aim of this study was to evaluate the protective effect of propylene glycol alginate (PGA) associated with sodium fluoride (NaF) against enamel erosion and erosion-abrasion.	propylene glycol alginate ester	63-88	C-X-C motif chemokine ligand 8	Homo sapiens	128-131
31509822-9	2020	IL-8 and IL-6 clearance were higher with Hemofeel (continuous venovenous hemodiafiltration) than with EMiC2 (continuous venovenous hemodialysis) because the polymethyl methacrylate (PMMA)-based membrane Hemofeel is able to remove these 2 cytokines by adsorption.	hemofeel	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
31509822-9	2020	IL-8 and IL-6 clearance were higher with Hemofeel (continuous venovenous hemodiafiltration) than with EMiC2 (continuous venovenous hemodialysis) because the polymethyl methacrylate (PMMA)-based membrane Hemofeel is able to remove these 2 cytokines by adsorption.	Polymethyl Methacrylate	157-180	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
31509822-9	2020	IL-8 and IL-6 clearance were higher with Hemofeel (continuous venovenous hemodiafiltration) than with EMiC2 (continuous venovenous hemodialysis) because the polymethyl methacrylate (PMMA)-based membrane Hemofeel is able to remove these 2 cytokines by adsorption.	hemofeel	203-211	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
33176315-1	2020	The aim of this study was to evaluate the protective effect of propylene glycol alginate (PGA) associated with sodium fluoride (NaF) against enamel erosion and erosion-abrasion.	Sodium Fluoride	111-126	C-X-C motif chemokine ligand 8	Homo sapiens	128-131
31522271-1	2020	PURPOSE: We evaluated the prognostic value of 18F-sodium fluoride (NaF) PET/CT in patients with urological malignancies treated with cabozantinib and nivolumab with or without ipilimumab.	18f-sodium fluoride	46-65	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
32056981-8	2020	Moreover, glucose-containing CM reduced the macrophage secretion of TNFalpha and IL-8 but elevated the IL-12 and IL-23 levels, showing an opposite pattern of distinct pro-inflammatory cytokines modulated by cancer glucose metabolites.	Glucose	10-17	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
31814524-0	2020	4-phenylbutyric acid promotes migration of gastric cancer cells by histone deacetylase inhibition-mediated IL-8 upregulation.	4-phenylbutyric acid	0-20	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
31814524-6	2020	Based on the expression profile microarray, IL-8 was the most significantly up-regulated gene by 4-PBA, and was selected for further investigation.	4-phenylbutyric acid	97-102	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
31814524-7	2020	Knockdown of IL-8 partially prevented 4-PBA-induced-EMT by blocking the activation of the downstream Gab2-ERK pathway.	4-phenylbutyric acid	38-43	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
31814524-8	2020	Furthermore, CHIP assay confirmed that acetyl-H3 directly combined with the promoter region of IL-8 to promote its transcription.	acetyl phosphate	39-45	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
31814524-9	2020	Therefore, the results of this study demonstrated that 4-PBA-mediated inhibition of HDAC activity could induce EMT in gastric cancer cells via acetyl-histone-mediated IL-8 upregulation, and the downstream Gab2/ERK activation.	4-phenylbutyric acid	55-60	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
31814524-9	2020	Therefore, the results of this study demonstrated that 4-PBA-mediated inhibition of HDAC activity could induce EMT in gastric cancer cells via acetyl-histone-mediated IL-8 upregulation, and the downstream Gab2/ERK activation.	acetyl phosphate	143-149	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
31715382-2	2020	Diagnosis of bone metabolic activity is currently through integrating Positron Emission Tomography (PET) with Sodium Fluoride (18F-NaF) biomarkers.	Sodium Fluoride	110-125	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
30417790-0	2020	Efficacy of beta-D-mannuronic acid [M2000] on pro-apoptotic process and inflammatory related molecules NFkB, IL-8 and Cd49d using healthy donor PBMC.	mannuronic acid	12-34	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
30417790-1	2020	This investigation evaluates the pro-apoptotic and anti-inflammatory effects of beta-D-mannuronic acid [M2000] compared to diclofenac, based on gene expression involved in apoptosis and inflammation process [including Bcl2, NFkappaB, IL-8 and Cd49d] in peripheral blood mononuclear cells [PBMCs] of healthy donors under exvivo conditions.	mannuronic acid	80-102	C-X-C motif chemokine ligand 8	Homo sapiens	234-238
32484090-11	2020	These PET scanners are mainly utilized with 18F-sodium-fluoride (NaF), in order to visualize the skeleton and possible changes.	18f-sodium-fluoride	44-63	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
31442679-7	2020	In the correlation analysis, albumin/creatinine ratio was significantly and positively correlated with IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6.	Creatinine	37-47	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
31442679-7	2020	In the correlation analysis, albumin/creatinine ratio was significantly and positively correlated with IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6.	Creatinine	37-47	C-X-C motif chemokine ligand 8	Homo sapiens	145-150
31522271-1	2020	PURPOSE: We evaluated the prognostic value of 18F-sodium fluoride (NaF) PET/CT in patients with urological malignancies treated with cabozantinib and nivolumab with or without ipilimumab.	cabozantinib	133-145	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
32071494-4	2020	The aim is to study the pre-analytical variations on the glucose estimation of using sodium fluoride-disodium EDTA (NaF-Na2EDTA) plasma (glycolysis inhibiting anticoagulant) and determine the fact behind the activity of glycolysis inhibition on the same.	Glucose	57-64	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
32114586-8	2020	CONCLUSION: Edaravone can improve the neurological function of patients without causing evident adverse reactions, thereby improving quality of life, which may be correlated to decreased serum TNF-alpha and IL-8 levels.	Edaravone	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	207-211
33118610-9	2020	Moreover, the protein levels of IL-8, TNF-alpha, and PGE2 were considerably reduced in IL-1beta-induced chondrocytes treated with different concentrations of TCA.	cinnamaldehyde	158-161	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
32361718-0	2020	Spectrum of false positive 18F-sodium fluoride (NaF) bone PET/CT findings in Oncology imaging; A narrative pictorial review of cases from a single institution.	18f-sodium fluoride	27-46	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
32361718-1	2020	Fluorine-18-sodium fluoride (18F-NaF) is a positron emission tomography (PET) bone imaging agent mainly used for oncology staging but may also be used in the evaluation of benign bone and joint pathology conditions.	fluorine-18-sodium fluoride	0-27	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
32071494-4	2020	The aim is to study the pre-analytical variations on the glucose estimation of using sodium fluoride-disodium EDTA (NaF-Na2EDTA) plasma (glycolysis inhibiting anticoagulant) and determine the fact behind the activity of glycolysis inhibition on the same.	Edetic Acid	85-114	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
30843768-5	2020	Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose.	alpha-Tocopherol	15-31	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
31821937-4	2020	The results demonstrated that treatment with xanthone reduced the production of pro-inflammatory cytokines and chemokines including interleukin (IL)-1beta, IL-6, IL-8, and expression of chemokines thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma-stimulated HaCaT cells.	Xanthones	45-53	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
31598775-4	2020	Various storage conditions, that is 4  C or room temperature (RT) and the addition of sodium fluoride (NaF), were compared during storage up to 30 days.	Sodium Fluoride	86-101	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
31598775-12	2020	The increase of GHB in HB samples with NaF was significantly lower than that without preservation.	Sodium Oxybate	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
30843768-5	2020	Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose.	alpha-Tocopherol	15-31	C-X-C motif chemokine ligand 8	Homo sapiens	284-288
30843768-5	2020	Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose.	Glucose	126-134	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
30843768-5	2020	Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose.	Glucose	126-134	C-X-C motif chemokine ligand 8	Homo sapiens	284-288
30843768-6	2020	However, ebselen treatment reduced IL-1beta, IL-6, and IL-8 levels in cells maintained in either 5.5 or 27.5 mM dextrose.	ebselen	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
30843768-5	2020	Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose.	Ascorbic Acid	61-74	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
30843768-5	2020	Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose.	Ascorbic Acid	61-74	C-X-C motif chemokine ligand 8	Homo sapiens	284-288
31791492-5	2020	Moreover, 1 mug/mL to 10 mug/mL carbon particle treatments disrupted the keratinocyte differentiation, and up-regulated inflammation- and psoriasis-related genes, such as IL-1beta, IL-6, CXCL1, CXCL2, CXCL3, CCL20, CXCL8, and S100A7 and S100A9, respectively.	Carbon	32-38	C-X-C motif chemokine ligand 8	Homo sapiens	215-220
32345772-6	2020	We found that RSV infection caused a marked increase in interleukin (IL)-6, IL-8, IL-1beta and tumor necrosis factor (TNF)- alpha production and release, which was concentration-dependently attenuated by EPB treatment.	ephedrannin B	204-207	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
32508149-0	2020	The Influence of Hypericin-Mediated Photodynamic Therapy on Interleukin-8 and -10 Secretion in Colon Cancer Cells.	hypericin	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	60-81
32508149-1	2020	The aim of this study was to measure the secretion of interleukin (IL)-8 and -10 during an elicited immune response following sublethal doses of hypericin-mediated photodynamic therapy (HY-PDT) in experimental models of residual colon cancer cells in vitro.	hypericin	145-154	C-X-C motif chemokine ligand 8	Homo sapiens	54-80
33223648-1	2020	Aim: The aim is to compare the effects of diode laser, GC tooth mousse, and sodium fluoride (NaF) varnish on dentinal hypersensitivity by scanning electron microscopic (SEM) evaluation.	Sodium Fluoride	76-91	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
32586185-5	2020	The control and NaF-treated cells were subjected to the influence of SMF with a moderate induction.	smf	69-72	C-X-C motif chemokine ligand 8	Homo sapiens	16-19
32863303-5	2020	Moreover, the mRNA expression of anti-inflammation cytokine (TGF-beta), tight junction (Occludin, ZO-1) in the jejunum by different ZnO administration were significantly increased compared with the NC group, while mRNA expression of pro-inflammatory (IL-8), membrane channels that transport water (AQP3) and miR-122a were significantly decreased.	Zinc Oxide	132-135	C-X-C motif chemokine ligand 8	Homo sapiens	251-255
32444566-12	2020	The secretion of IL-8 in 45% FiO2 with xenon at 32 C was greater than that of other groups.	Xenon	39-44	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
31939174-3	2020	In this chapter, we describe a protocol for the analysis of TNBC cell invasion induced by IL-8 in response to proteasome inhibition by bortezomib (BZ).	bortezomib	135-145	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
32581181-7	2020	In pretreated gingival fibroblasts and HSC-2 cells, TCA considerably reduced the expression of IL1beta, IL6, and IL8.	Taurocholic Acid	52-55	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
31939174-3	2020	In this chapter, we describe a protocol for the analysis of TNBC cell invasion induced by IL-8 in response to proteasome inhibition by bortezomib (BZ).	bortezomib	147-149	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
31939174-4	2020	Using this approach, we show that BZ increases the invasion ability of TNBC cells, and that the BZ-increased TNBC cell invasion is suppressed by IkappaB kinase (IKK) inhibition, which also decreases the IL-8 expression.	bortezomib	96-98	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
31604846-10	2020	Likewise, AR knockdown in androgen-dependent cells induced IL-8 expression, further demonstrating that AR represses IL-8 expression.	Androgens	26-34	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
31604846-10	2020	Likewise, AR knockdown in androgen-dependent cells induced IL-8 expression, further demonstrating that AR represses IL-8 expression.	Androgens	26-34	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
33198933-7	2020	After 6 h incubation with MMC, both HCAEC and HITAEC displayed a decrease in IL8 concentration and the mRNA level of IL6 and IL8 compared to control cells.	Mitomycin	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
33198933-7	2020	After 6 h incubation with MMC, both HCAEC and HITAEC displayed a decrease in IL8 concentration and the mRNA level of IL6 and IL8 compared to control cells.	Mitomycin	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	125-128
33198933-10	2020	These findings suggest that the MMC-induced genotoxic stress in endothelial cells derived from different arteries is associated with differential secretion and gene expression of proinflammatory cytokines IL6 and IL8.	Mitomycin	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	213-216
32441198-3	2020	In addition, serum levels of TNF-alpha, IL-1beta, IL-6, IL-8, and tumor marker CEA were decreased significantly in omega-3, vitamin D, and co-supplementation of them, compared with baseline.	Fatty Acids, Omega-3	115-122	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
32894857-9	2020	Five days after the last dose, serum IL-2 and IL-8 levels dropped significantly in the azithromycin group.	Azithromycin	87-99	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
32294654-11	2020	RESULTS: Treating cultured hCMEC/D3 human cells with poly IC induced the expression of CXCL1 as well as another chemokine CXCL8.	Poly I-C	53-60	C-X-C motif chemokine ligand 8	Homo sapiens	122-127
31764599-8	2020	The overall burden of calcium deposition was also significantly correlated with metabolic syndrome (P = 0.002) and 10-year cardiovascular disease risk score (P = 0.004) CONCLUSION: F-NaF uptake is closely related to diabetes mellitus, whereas aortic calcification on CT is closely related to hypertension.	Calcium	22-29	C-X-C motif chemokine ligand 8	Homo sapiens	183-186
32454491-7	2020	Furthermore, YiQi GuBen formula suppressed PDGF-BB-induced expression of phosphorylated p65 and the release of inflammatory factors TNF-alpha, IL-1beta, IL-6, and IL-8 in ASMCs.	yiqi guben	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
32441198-3	2020	In addition, serum levels of TNF-alpha, IL-1beta, IL-6, IL-8, and tumor marker CEA were decreased significantly in omega-3, vitamin D, and co-supplementation of them, compared with baseline.	Vitamin D	124-133	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
32515426-1	2020	PURPOSE: To assess the effects of experimental titanium tetrafluoride (TiF4) varnish and commercial sodium fluoride (NaF) varnish with CO2 laser on enamel hardness.	Sodium Fluoride	100-115	C-X-C motif chemokine ligand 8	Homo sapiens	117-120
32515426-6	2020	NaF varnish (2.26%) with CO2 laser (NFL); 6.	Carbon Dioxide	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
31888596-7	2019	The group comparison between filtered air and ZnO exposures showed statistically significant increases of neutrophils and interleukin-8 (IL-8), interleukin-6 (IL-6), matrix metalloproteinase (MMP-9) and tissue inhibitors of metalloproteinases (TIMP-1) in sputum starting at the lowest ZnO concentration of 0.5 mg/m3.	Zinc Oxide	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	122-135
31705795-2	2020	Using an in vitro model, we previously reported that hyperglycemic levels of glucose induced a pro-inflammatory (IL-1beta, IL-8, RANTES, GRO-alpha), anti-angiogenic (sFlt-1) and anti-migratory profile in a human trophoblast cell line.	Glucose	77-84	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
31705795-6	2020	Under excess glucose conditions, allopurinol significantly inhibited trophoblast secretion of inflammatory IL-1beta; caspase-1 activity; IL-8; RANTES; and GRO-alpha.	Allopurinol	33-44	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
31705795-8	2020	The presence of IL1Ra significantly inhibited excess glucose-induced trophoblast IL-8 and GRO-alpha secretion but had no effect on RANTES or sFlt-1.	Glucose	53-60	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
31888596-7	2019	The group comparison between filtered air and ZnO exposures showed statistically significant increases of neutrophils and interleukin-8 (IL-8), interleukin-6 (IL-6), matrix metalloproteinase (MMP-9) and tissue inhibitors of metalloproteinases (TIMP-1) in sputum starting at the lowest ZnO concentration of 0.5 mg/m3.	Zinc Oxide	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
31888640-7	2019	RESULTS: Ticagrelor and clopidogrel can inhibit the degradation of IKBalpha and phosphorylation of p65, prevent p65 from entering the nucleus, reduce the production of TNFalpha, IL-1, IL-8, IL-6 and IL-2, and alleviate the decrease in cell viability, cell migration and angiogenesis, the changes of cell cycle and apoptosis induced by LPS.	Ticagrelor	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
31888640-7	2019	RESULTS: Ticagrelor and clopidogrel can inhibit the degradation of IKBalpha and phosphorylation of p65, prevent p65 from entering the nucleus, reduce the production of TNFalpha, IL-1, IL-8, IL-6 and IL-2, and alleviate the decrease in cell viability, cell migration and angiogenesis, the changes of cell cycle and apoptosis induced by LPS.	Clopidogrel	24-35	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
31864360-8	2019	RESULTS: CF cells exposed to digitoxin exhibited significant suppression of both TNFalpha/NFkappaB signaling and downstream secretion of IL-8, IL-6 and GM-CSF, with or without co-treatment with VX drugs.	Digitoxin	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
31892218-5	2019	The hDPSCs exposed to HEMA let to an increment of ROS formation and in the expression of high levels of inflammatory mediators such as nuclear factor-kappaB (NFkB), inflammatory cytokines such as interleukin IL6, IL8, interferon (IFN)gamma and monocyte chemoattractant protein (MCP)1.	poly(2-hydroxyethylmethacrylate)-TiO2	22-26	C-X-C motif chemokine ligand 8	Homo sapiens	213-239
31877842-4	2019	By using a combined salt of 95%NaCl + 5%NaF, an effective liquid reaction medium was formed, greatly facilitating the Al8B4C7 formation.	aluminum boride	118-125	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
31877739-10	2019	Cytotoxic effects of P6 peptide, colchicine, and colchicine-P6 peptide on macrophages were compared and the inhibition of ROS generation and interleukin-8 (IL-8) secretion in MSU-stimulated macrophages treated with P6 peptide, colchicine, or colchicine-P6 peptide was studied.	Uric Acid	175-178	C-X-C motif chemokine ligand 8	Homo sapiens	141-154
31877739-14	2019	The colchicine-P6 peptide significantly reduced ROS generation and IL-8 secretion compared to the P6 peptide alone at 1 and 10 muM concentrations.	Colchicine	4-14	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
31526917-5	2019	CCL2 (p = 0.039), and CCL5 (p = 0.001) levels were significantly higher in fingolimod-treated patients than healthy controls, whereas end-of-study serum levels of IL-6, IL-8, IL-17A, IL-22, IL-23, TNF-alpha, CXCL10, and CXCL13 were comparable to the baseline levels.	Fingolimod Hydrochloride	75-85	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
31862943-6	2019	The duration of action of intravitreal dexamethasone implants in DME patients was associated with the level of aqueous IL-8 and the number of HF using OCT.	Dexamethasone	39-52	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
31888128-5	2019	The effect of the extracts, diosmin, 1-octen-3-ol on the secretion of pro-inflammatory cytokines, IL-6 (A) and IL-8 (B) by human dermal fibroblasts was significant (p &lt; 0.001).	1-octen-3-ol	37-49	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
31610186-4	2019	Among the 17 flavonoids tested, only apigenin (flavones), luteolin (flavones), daidzein (isoflavones) and genistein (isoflavones) reduced LPS-induced release of inflammatory cytokines/chemokines interleukin (IL)-6, IL-8 and monocyte chemoattractant protein-1 in BEAS-2B cells.	Genistein	106-115	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
31610186-5	2019	Quercetin caused further increase in LPS-induced IL-6 and IL-8 levels.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
31610186-8	2019	Apigenin and genistein, but not quercetin, increased the cAMP level in BEAS-2B cells, and the cell-permeable cAMP analogue, 8-Br-cAMP, inhibited LPS-induced increase of IL-8 level.	Apigenin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
31851935-3	2019	Metformin interrupts bidirectional signaling between tumor and mesothelial cells by blocking OvCa cell TGF-beta signaling and mesothelial cell production of CCL2 and IL-8.	Metformin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
31851935-6	2019	Disruption of HIF1alpha-driven IL-8 signaling in mesothelial cells by metformin results in reduced OvCa invasion in an organotypic 3D model.	Metformin	70-79	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
31844123-9	2019	In addition, Sch A decreased the DON-induced cyclooxygenase-2 expression and prostaglandin E2 production and pro-inflammatory cytokine interleukin 8 expression and secretion.	schizandrin A	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	135-148
31610186-8	2019	Apigenin and genistein, but not quercetin, increased the cAMP level in BEAS-2B cells, and the cell-permeable cAMP analogue, 8-Br-cAMP, inhibited LPS-induced increase of IL-8 level.	Genistein	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
31610186-8	2019	Apigenin and genistein, but not quercetin, increased the cAMP level in BEAS-2B cells, and the cell-permeable cAMP analogue, 8-Br-cAMP, inhibited LPS-induced increase of IL-8 level.	Cyclic AMP	109-113	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
31610186-8	2019	Apigenin and genistein, but not quercetin, increased the cAMP level in BEAS-2B cells, and the cell-permeable cAMP analogue, 8-Br-cAMP, inhibited LPS-induced increase of IL-8 level.	8-Bromo Cyclic Adenosine Monophosphate	124-133	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
31811113-4	2019	RESULTS Cells predisposed to MG demonstrated an increase in oxidative stress with augmented (P&lt;0.01) inflammatory cytokines such as cyclooxygenase (COX)-2, chemokine receptor CXCR4, interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule 1 (ICAM-1) genes.	Pyruvaldehyde	29-31	C-X-C motif chemokine ligand 8	Homo sapiens	205-209
31733592-6	2019	This was demonstrated using the argininocalix[4]arene 1 in miRNA therapeutic approaches performed on three well-described experimental model systems: (1) the induction of apoptosis by antimiR-221 in glioma U251 cells; (2) the induction of apoptosis by premiR-124 in U251 cells; and (3) the inhibition of pro-inflammatory IL-8 and IL-6 genes in cystic fibrosis IB3-1 cells.	calix(4)arene	32-53	C-X-C motif chemokine ligand 8	Homo sapiens	321-325
31817562-7	2019	High-glucose conditions increased glucose transporters, glucose influx, ROS, all the high-glucose-induced harmful pathways, TGF-beta1 and IL-8, cell apoptosis, and MMT.	Glucose	5-12	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
31849953-8	2019	On the other hand, Toll-like receptor 4 blockade significantly reduced PA-induced IL-8 secretion by osteoblasts, while blocking Toll-like receptor 2 had no effect.	Palmitic Acid	71-73	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
31805999-0	2019	PTPRD-inactivation-induced CXCL8 promotes angiogenesis and metastasis in gastric cancer and is inhibited by metformin.	Metformin	108-117	C-X-C motif chemokine ligand 8	Homo sapiens	27-32
31824163-9	2019	Supplementation with CoQ10 demonstrated a significant decrease in IL-8 and IL-6 serum levels compared to placebo (P&lt; 0.05).	coenzyme Q10	21-26	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
31849953-9	2019	In osteoclasts, IL-8 secretion was enhanced by PA and LA particularly at the earliest time point of differentiation.	Palmitic Acid	47-49	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
31571042-2	2019	The present study aimed to evaluate the association between carotid 18F-sodium fluoride (NaF) and 18F-fluorodeoxyglucose (FDG) uptake with the severity of ischemic vascular brain disease on MRI in patients with carotid artery disease.	Sodium Fluoride	68-87	C-X-C motif chemokine ligand 8	Homo sapiens	89-92
31470141-0	2019	Reversine inhibits MMP-3, IL-6 and IL-8 expression through suppression of ROS and JNK/AP-1 activation in interleukin-1beta-stimulated human gingival fibroblasts.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
31297987-11	2019	In THP-1 cell assays, MSU crystals grown with healthy cartilage homogenate increased the release of interleukin-8, whereas MSU crystals grown with type II collagen or albumin had no effect on inflammatory cytokine release.	Uric Acid	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	100-113
31407195-12	2019	The levels of plasma inflammatory markers were significantly decreased in BA group after 7 days of intervention in TNF-alpha, IL-1beta, IL-6, IL-8, and PGE2.	boswellic acid	74-76	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
31751886-10	2019	Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation.	Curcumin	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	109-114
31751886-10	2019	Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation.	Curcumin	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
31751886-10	2019	Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation.	Capsaicin	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	109-114
31751886-10	2019	Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation.	Capsaicin	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
31546097-5	2019	Exposure to HA mineral in scaffolds increased the expression of pro-tumorigenic interleukin-8 (IL-8) among transformed but not benign cells.	Durapatite	12-14	C-X-C motif chemokine ligand 8	Homo sapiens	80-93
31546097-5	2019	Exposure to HA mineral in scaffolds increased the expression of pro-tumorigenic interleukin-8 (IL-8) among transformed but not benign cells.	Durapatite	12-14	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
30997568-11	2019	CLINICAL RELEVANCE: Brushing with a NaF-containing dentifrice can rapidly improve remineralisation, enamel erosion resistance and fluoride uptake.	Fluorides	130-138	C-X-C motif chemokine ligand 8	Homo sapiens	36-39
31949929-10	2019	Results: Ex vivo drug treatment of 49 primary gastric cultures from naive patients revealed a significant correlation between basal levels of IL-8 and chemosensitivity to cisplatin (P=0.001) and oxaliplatin (P=0.001).	Cisplatin	171-180	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
31612365-4	2019	Therefore, the aim of the study was to investigate influence of NADPH oxidase inhibition on the expression of IL-6, IL-8, TNF, TSLP, CD59, and PPAR-gamma in vitro.	NADP	64-69	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
31612365-8	2019	The time-response and dose-response study showed that apocynin significantly influenced the relative expression of chosen genes (IL-6, IL-8, TNF, PPAR-gamma, TSLP, and CD59).	acetovanillone	54-62	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
31949929-11	2019	IL-8 protein expression levels were significantly decreased in the early phase after cisplatin and oxaliplatin treatments leading to an increase in cell sensitivity to drug treatments.	Cisplatin	85-94	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
31949929-11	2019	IL-8 protein expression levels were significantly decreased in the early phase after cisplatin and oxaliplatin treatments leading to an increase in cell sensitivity to drug treatments.	oxaliplatin	99-110	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
31949929-16	2019	The established primary gastric culture could serve as a valuable tool for chemotherapy screening, while the repeated usage of platinum drugs may result in drug resistance via upregulation of IL-8 levels.	Platinum	127-135	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
31578786-8	2019	The secretion of SASP components, including interleukin (IL)-8, IL-6, and C-C motif chemokine ligand 2 was also substantially reduced in the presence of PC.	Phosphatidylcholines	153-155	C-X-C motif chemokine ligand 8	Homo sapiens	44-62
31424110-1	2019	This study characterized the distribution of [18 F]-sodium fluoride (NaF) uptake and blood flow in the femur and acetabulum in hip osteoarthritis (OA) patients to find associations between bone remodeling and cartilage composition in the presence of morphological abnormalities using simultaneous positron emission tomography and magnetic resonance imaging (PET/MR), quantitative magnetic resonance imaging (MRI) and femur shape modeling.	Sodium Fluoride	52-67	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
31866771-5	2019	Results: (1) The levels of hs-CRP, IL-6, and IL-8 were significantly increased in the UAP and AMI groups compared with the CPS group (P < 0.01).	4-Deoxy-2-O-Sulfo-Alpha-L-Threo-Hex-4-Enopyranuronic Acid	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
31147402-1	2019	The aim of this study was to determine if additional 18F-sodium fluoride PET/CT (NaF PET/CT) improves the prognostic accuracy in the initial staging of prostate cancer patients with normal bone scintigraphy undergoing prostatectomy.	18f-sodium fluoride	53-72	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
31639635-5	2019	We observed a dramatic reduction of neutrophils oxidative burst, Fc gamma receptors (FcgammaRs)-mediated degranulation and IL-8 plasma levels already after the first forty-eight hours of therapy with ibrutinib.	ibrutinib	200-209	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
31520180-9	2019	The secreted levels of IL-8, TNF-alpha, IL-6 and IL-17A induced by silica particles were also significantly lower from CTGF siRNA-transfected cells than that from normal 16HBE cells (P &lt; 0.05).	Silicon Dioxide	67-73	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
31520180-7	2019	The secretions of IL-8, TNF-alpha, IL-6 and IL-17A were also significantly increased by silica particles (P &lt; 0.05).	Silicon Dioxide	88-94	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
31639635-9	2019	In conclusion, during the initial phases of ibrutinib therapy, the reduction of IL-8, NE, myeloperoxidase (MPO) levels and oxidative burst negatively impacted on mechanisms involved in neutrophils microbicidal activity.	ibrutinib	44-53	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
31515297-11	2019	Notably, combination fenretinide-tocilizumab-reparixin treatment significantly suppressed IL-6 and IL-8 release, stem cell gene expression, and invasion in these diverse CSCE populations.	Fenretinide	21-32	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
31515297-11	2019	Notably, combination fenretinide-tocilizumab-reparixin treatment significantly suppressed IL-6 and IL-8 release, stem cell gene expression, and invasion in these diverse CSCE populations.	reparixin	45-54	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
31808632-8	2019	RESULTS: In the appointment of lercanidipine, there was a more rapid decrease in levels of IL-8, VEGF, MS-1, GM-CSF in serum (21 days), and an improvement in renal function, compared with the group that did not receive nephroprotective therapy.	lercanidipine	31-44	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
31885477-6	2019	DB103 inhibited the induced-release of angiogenic factors such as monocyte chemotactic protein-1, interleukin-6 (IL-6) and angiopoietin-2 but not IL-8, while apigenin reduced the IL-6 and IL-8 release.	Apigenin	158-166	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
31493545-6	2019	It was found as expected that AgNP induced significant release of IL-1beta, IL-6, IL-8 and TNF-alpha in THP1 monocytes more than the basal level.	agnp	30-34	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
31493545-8	2019	In TDMs, AgNP and Lipo-AgNP induced IL-8 release (p < .0001), but Lipo-AgNP maintained IL-8 release at levels significantly lower than that of AgNP (p < .01).	agnp	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
31493545-8	2019	In TDMs, AgNP and Lipo-AgNP induced IL-8 release (p < .0001), but Lipo-AgNP maintained IL-8 release at levels significantly lower than that of AgNP (p < .01).	lipo-agnp	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
31493545-8	2019	In TDMs, AgNP and Lipo-AgNP induced IL-8 release (p < .0001), but Lipo-AgNP maintained IL-8 release at levels significantly lower than that of AgNP (p < .01).	lipo-agnp	66-75	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
31493545-8	2019	In TDMs, AgNP and Lipo-AgNP induced IL-8 release (p < .0001), but Lipo-AgNP maintained IL-8 release at levels significantly lower than that of AgNP (p < .01).	agnp	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
31779275-6	2019	Transcriptional profiling revealed that various genes coding for cytokines and other proinflammatory proteins were upregulated upon recombinant alpha-MMC treatment in THP-1 cells, including MCP-1, IL-8, IL-1beta, and TNF-alpha.	MK 316	144-153	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
31720603-3	2019	It is revealed that the SEI layer contains a large amount of NaF and O-As-O polymer which enables the stable cycling of sodium metal anodes.	Sodium	120-126	C-X-C motif chemokine ligand 8	Homo sapiens	61-64
31548455-7	2019	Pre-incubation of the cells with BAPTA-AM and L-glutathione increased IL-8 secretion, which indicates that Ca2+ ions and reactive oxygen species are associated with the ouabain-mediated reduction in IL-8 levels.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
31548455-7	2019	Pre-incubation of the cells with BAPTA-AM and L-glutathione increased IL-8 secretion, which indicates that Ca2+ ions and reactive oxygen species are associated with the ouabain-mediated reduction in IL-8 levels.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
31548455-7	2019	Pre-incubation of the cells with BAPTA-AM and L-glutathione increased IL-8 secretion, which indicates that Ca2+ ions and reactive oxygen species are associated with the ouabain-mediated reduction in IL-8 levels.	Glutathione	46-59	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
31548455-7	2019	Pre-incubation of the cells with BAPTA-AM and L-glutathione increased IL-8 secretion, which indicates that Ca2+ ions and reactive oxygen species are associated with the ouabain-mediated reduction in IL-8 levels.	Glutathione	46-59	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
31548455-7	2019	Pre-incubation of the cells with BAPTA-AM and L-glutathione increased IL-8 secretion, which indicates that Ca2+ ions and reactive oxygen species are associated with the ouabain-mediated reduction in IL-8 levels.	Calcium	107-111	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
31548455-7	2019	Pre-incubation of the cells with BAPTA-AM and L-glutathione increased IL-8 secretion, which indicates that Ca2+ ions and reactive oxygen species are associated with the ouabain-mediated reduction in IL-8 levels.	Calcium	107-111	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
31548455-7	2019	Pre-incubation of the cells with BAPTA-AM and L-glutathione increased IL-8 secretion, which indicates that Ca2+ ions and reactive oxygen species are associated with the ouabain-mediated reduction in IL-8 levels.	Oxygen	130-136	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
31548455-7	2019	Pre-incubation of the cells with BAPTA-AM and L-glutathione increased IL-8 secretion, which indicates that Ca2+ ions and reactive oxygen species are associated with the ouabain-mediated reduction in IL-8 levels.	Ouabain	169-176	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
31548455-7	2019	Pre-incubation of the cells with BAPTA-AM and L-glutathione increased IL-8 secretion, which indicates that Ca2+ ions and reactive oxygen species are associated with the ouabain-mediated reduction in IL-8 levels.	Ouabain	169-176	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
31725301-8	2019	In contrast, the stability of C12GlyNa-containing foams followed the trend NaF > NaCl > NaSCN, which is in agreement with NaF promoting and NaSCN breaking intersurfactant H-bonds.	c12glyna	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
31725301-8	2019	In contrast, the stability of C12GlyNa-containing foams followed the trend NaF > NaCl > NaSCN, which is in agreement with NaF promoting and NaSCN breaking intersurfactant H-bonds.	c12glyna	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	122-125
31725301-8	2019	In contrast, the stability of C12GlyNa-containing foams followed the trend NaF > NaCl > NaSCN, which is in agreement with NaF promoting and NaSCN breaking intersurfactant H-bonds.	sodium thiocyanate	88-93	C-X-C motif chemokine ligand 8	Homo sapiens	122-125
31769424-7	2019	Mechanistically, IL-8-induced myotube atrophy is inhibited by treatment with the CXCR2 antagonist, SB225002, or by treatment with the ERK1/2 inhibitor, U0126.	SB 225002	99-107	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
31766770-10	2019	BIRB796 and SB203580 reduced TNFalpha-induced IL-8.	SB 203580	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
31769424-7	2019	Mechanistically, IL-8-induced myotube atrophy is inhibited by treatment with the CXCR2 antagonist, SB225002, or by treatment with the ERK1/2 inhibitor, U0126.	U 0126	152-157	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
31871502-8	2019	However, IL-12, IP-10, and TNF-alpha had no correlation with DR and DME, whereas there was a significant relationship between IL-8 and DME (1.68 (0.97, 2.40)).	dimethylethylsilylimidazole	135-138	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
31766770-11	2019	SB203580 reduced LPS-induced IL-8.	SB 203580	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
31766770-12	2019	Fluticasone/formoterol, fluticasone/salmeterol, and fluticasone/BIRB796, but not fluticasone/SB203580 combinations, reduced TNFalpha-induced IL-8 stronger than single treatments.	fp	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
31766770-12	2019	Fluticasone/formoterol, fluticasone/salmeterol, and fluticasone/BIRB796, but not fluticasone/SB203580 combinations, reduced TNFalpha-induced IL-8 stronger than single treatments.	fp	24-35	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
31766770-12	2019	Fluticasone/formoterol, fluticasone/salmeterol, and fluticasone/BIRB796, but not fluticasone/SB203580 combinations, reduced TNFalpha-induced IL-8 stronger than single treatments.	fp	52-63	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
31766770-12	2019	Fluticasone/formoterol, fluticasone/salmeterol, and fluticasone/BIRB796, but not fluticasone/SB203580 combinations, reduced TNFalpha-induced IL-8 stronger than single treatments.	fp	52-63	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
31766770-13	2019	All combinations including fluticasone/SB203580 reduced LPS-induced IL-8 stronger than single treatments.	fp	27-38	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
31766770-13	2019	All combinations including fluticasone/SB203580 reduced LPS-induced IL-8 stronger than single treatments.	SB 203580	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
31752330-7	2019	Cluster analysis demonstrated that patients from cluster three, with the lowest 25(OH)D levels, presented the lowermost vitamin D intake, IL-10 (1.0 +- 0.9 pg/mL), and IL-12p70 (0.5 +- 0.4 pg/mL), but the highest TNF-alpha (9.1 +- 3.5 pg/mL), IL-8 (55.6 +- 117.1 pg/mL), IL-17A (3.5 +- 2.0 pg/mL), total-cholesterol (193.9 +- 61.4 mg/dL), LDL-cholesterol (127.7 +- 58.2 mg/dL), and Apo-B (101.4 +- 33.4 mg/dL) levels, compared with patients from cluster one.	25(oh)d	80-87	C-X-C motif chemokine ligand 8	Homo sapiens	243-247
31257245-5	2019	The children with RMPP had significantly higher BALF levels of IL-8, IL-17 and TNF-alpha than the children with GMPP (P&lt;0.05), and the elevated levels of IL-17 correlated with the focal size of the lung lesions (P&lt;0.05).	rmpp	18-22	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
31741329-1	2021	BACKGROUND: Fluoride-18 sodium fluoride (18F-NaF) localizes in microcalcifications in atheroma.	Sodium Fluoride	12-39	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
31741329-1	2021	BACKGROUND: Fluoride-18 sodium fluoride (18F-NaF) localizes in microcalcifications in atheroma.	CP-18 compound	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
31741329-9	2021	NaF uptake correlated with calcium volume on the baseline scan (P = .60, &lt; .0001 ) and calcium volume increment, especially from 1.0 to 1.5 years (r = .79, P &lt; .0001 ).	Calcium	27-34	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
31741329-9	2021	NaF uptake correlated with calcium volume on the baseline scan (P = .60, &lt; .0001 ) and calcium volume increment, especially from 1.0 to 1.5 years (r = .79, P &lt; .0001 ).	Calcium	90-97	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
31741329-10	2021	Patients with persistently high NaF uptake showed a higher calcium volume increment (0-1.5 years) than patients with low or transiently high NaF uptake.	Calcium	59-66	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
31741329-12	2021	NaF uptake on the baseline scans and high NaF uptake on the serial scans preceded an increase in calcium volume, especially by 1.0-1.5 years.	Calcium	97-104	C-X-C motif chemokine ligand 8	Homo sapiens	42-45
31741329-13	2021	Persistently high NaF uptake was associated with a greater increment in calcium volume than patients with transiently elevated or persistently low fluoride uptake.	Calcium	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
31722538-3	2021	Results showed that the levels of Benzo[a]pyrene diol epoxide (BPDE) DNA adduct in blood and IL-8 in serum in case group were significantly higher than those in control group (p &lt; 0.01).	benzo(a)pyrene 4,5-epoxide	34-61	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
31585112-11	2019	However, the increased secretion of inflammatory cytokines (IL-6 and IL-8) is sustained and these mediators may be involved in the pathophysiology of bladder toxicity following intravesical epirubicin treatment.	Epirubicin	190-200	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
31827376-10	2019	Furthermore, the pretreatment of THP-1 cells with either NAC or a selective EGFR inhibitor significantly blocked DEP-induced IL-8 expression, implying that oxidative stress and subsequent EGFR activation mediated DEP-induced inflammatory response.	Acetylcysteine	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
31730488-11	2019	Conditioned medium of IPTD-MSCs treated with a combination of DMOG and TNF-alpha contained higher levels of pro-angiogenic (VEGF, IL-6, and IL-8) compared to controls, promoting angiogenesis of human endothelial cells in vitro.	Glyprothiazol	22-26	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
31730488-11	2019	Conditioned medium of IPTD-MSCs treated with a combination of DMOG and TNF-alpha contained higher levels of pro-angiogenic (VEGF, IL-6, and IL-8) compared to controls, promoting angiogenesis of human endothelial cells in vitro.	dimethyloxallyl glycine	62-66	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
31323583-7	2019	We found that DEHP at the indicated concentration plus 50.00muM BaP increased cellular and mitochondrial ROS levels, IL-6 and IL-8 secretions at 24 and 48h as well as MDA levels and GSH-Px activities at 48h, compared to the solvent control.	Diethylhexyl Phthalate	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
31323583-7	2019	We found that DEHP at the indicated concentration plus 50.00muM BaP increased cellular and mitochondrial ROS levels, IL-6 and IL-8 secretions at 24 and 48h as well as MDA levels and GSH-Px activities at 48h, compared to the solvent control.	Benzo(a)pyrene	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
31739592-7	2019	In addition, celastrol suppressed the release of pro-inflammatory cytokines TNF-alpha and IL-8 in HGC27 and AGS cells, which was reversed by over-expression BGN.	celastrol	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
31718684-0	2019	Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies.	Acetylcarnitine	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	88-93
31718684-13	2019	ALCAR exerts angiopreventive activities on PCa by reducing production/release of pro angiogenic factors (VEGF, CXCL8, CCL2, angiogenin) and metalloprotease MMP-9.	Acetylcarnitine	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	111-116
31708994-7	2019	Initial exposure to H2O2 or TNFalpha enhanced SF senescence and increased mRNA expression of IL6, CXCL8, CCL2 and MMP3 and proteins secretion.	Water	20-24	C-X-C motif chemokine ligand 8	Homo sapiens	98-103
31703101-5	2019	Significantly elevated faecal sIgA levels during administration of metformin, and its correlation with the expression of genes associated with immune response (CXCR4, HLA-DQA1, MAP3K14, TNFRSF21, CCL4, ACVR1B, PF4, EPOR, CXCL8) supports a novel hypothesis of strong association between metformin and intestinal immune system, and for the first time provide evidence for altered RNA expression as a contributing mechanism of metformin"s action.	Metformin	67-76	C-X-C motif chemokine ligand 8	Homo sapiens	221-226
31708994-9	2019	Treatment of senescent SF with the senolytic drug fenofibrate normalized IL6, CXCL8 and CCL2 mRNA expression.	Fenofibrate	50-61	C-X-C motif chemokine ligand 8	Homo sapiens	78-83
31411059-12	2019	mRNA expression of proinflammatory and profibrotic factors (TNF-alpha, IL-1, IL-8, MMP3) was elevated by hyperoxia or etoposide.	Etoposide	118-127	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
31741708-7	2019	In NHT cells, phenformin affected cell-viability only at the maximal dose but interestingly it inhibited CXCL8 secretion at all the concentrations not affecting cell-viability.	Phenformin	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	105-110
31741708-9	2019	Thus, phenformin exerts anti-cancer effects on both cancer cells (cell death induction) and surrounding normal cells (inhibition of CXCL8 secretion).	Phenformin	6-16	C-X-C motif chemokine ligand 8	Homo sapiens	132-137
31684995-10	2019	When we stimulated HCC cells with exogenous IL-8, cell invasion and the levels of integrin beta3, p-PI3K, and p-Akt increased, which could be effectively reversed by adding PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
31385011-1	2019	PURPOSE: To improve the test-retest reproducibility of coronary plaque 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) uptake measurements.	18f-sodium fluoride	71-90	C-X-C motif chemokine ligand 8	Homo sapiens	96-99
31257011-9	2019	Furthermore, montelukast reduced IL-8 (P<.001) production by LPS-treated human neutrophils.	montelukast	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
31496351-9	2019	PMA-induced NETosis directly upregulated the TLR9/NF-kappaB pathway in macrophages and subsequently initiated the release of IL-8.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
30580454-5	2019	Secretion of interleukin-8 from adipose tissue explants was reduced after saxagliptin (median fold-change from baseline: 0.8 saxagliptin vs 3.3 placebo; P=0.02).	saxagliptin	74-85	C-X-C motif chemokine ligand 8	Homo sapiens	13-26
30580454-5	2019	Secretion of interleukin-8 from adipose tissue explants was reduced after saxagliptin (median fold-change from baseline: 0.8 saxagliptin vs 3.3 placebo; P=0.02).	saxagliptin	125-136	C-X-C motif chemokine ligand 8	Homo sapiens	13-26
31385012-2	2019	Imaging studies using [18F]-sodium fluoride ([18F]NaF) have found changes in tracer kinetics in animals after subjecting bones to strain, indicating an acute physiological response.	[18f]-sodium fluoride	22-43	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
31408726-8	2019	Furthermore, exposure of primary human monocyte-derived DCs (moDC) to 8-oxoG base resulted in significantly enhanced expression of cell surface molecules (CD40, CD86, CD83, HLA-DQ) and augmented the secretion of pro-inflammatory mediators IL-6, TNF and IL-8, whereas it did not considerably influence the production of the anti-inflammatory cytokine IL-10.	8-oxog base	70-81	C-X-C motif chemokine ligand 8	Homo sapiens	253-257
31545398-8	2019	The present study also demonstrated that bexarotene exerted an anti-inflammatory effect by downregulating expression of interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1, and high mobility group box-1.	Bexarotene	41-51	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
31683341-0	2019	Treatment with Metformin and Combination of Metformin Plus Pioglitazone on Serum Levels of IL-6 and IL-8 in Polycystic Ovary Syndrome: A Randomized Clinical Trial.	Metformin	44-53	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
31683341-0	2019	Treatment with Metformin and Combination of Metformin Plus Pioglitazone on Serum Levels of IL-6 and IL-8 in Polycystic Ovary Syndrome: A Randomized Clinical Trial.	Pioglitazone	59-71	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
31683341-14	2019	Combination of metformin and pioglitazone therapy was more effective as compared to metformin alone in reducing the levels of IL-6 and IL-8 as well as insulin resistance in PCOS.	Metformin	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
31683341-14	2019	Combination of metformin and pioglitazone therapy was more effective as compared to metformin alone in reducing the levels of IL-6 and IL-8 as well as insulin resistance in PCOS.	Pioglitazone	29-41	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
31683341-14	2019	Combination of metformin and pioglitazone therapy was more effective as compared to metformin alone in reducing the levels of IL-6 and IL-8 as well as insulin resistance in PCOS.	Metformin	84-93	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
31065903-5	2019	RESULTS: IL-8 levels were significantly higher in the AqH of patients with BU and FUS than in the AqH of control subjects (p < 0.001 and p < 0.001, respectively).	bu	75-77	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
31065903-5	2019	RESULTS: IL-8 levels were significantly higher in the AqH of patients with BU and FUS than in the AqH of control subjects (p < 0.001 and p < 0.001, respectively).	fusarubin	82-85	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
31437494-7	2019	CBD significantly attenuated LPS-induced NF-kappaB activity, IL-8, and MCP-1 release from macrophages.	Cannabidiol	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
31546233-3	2019	24 and/or 48 hours exposure to BPA 0.1 nM elicited significant increase of the inflammatory molecules interleukin-6 (IL-6), interleukin-8 (IL-8), Monocyte chemo-attractant protein 1alpha (MCP1alpha) and induced G protein-coupled estrogen receptor 30 (GPR30) levels more than 2-fold both in mature adipocytes and SVF cells.	bisphenol A	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	124-137
31546233-3	2019	24 and/or 48 hours exposure to BPA 0.1 nM elicited significant increase of the inflammatory molecules interleukin-6 (IL-6), interleukin-8 (IL-8), Monocyte chemo-attractant protein 1alpha (MCP1alpha) and induced G protein-coupled estrogen receptor 30 (GPR30) levels more than 2-fold both in mature adipocytes and SVF cells.	bisphenol A	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
31546233-8	2019	Interestingly, the action of BPA on SVF cell growth was mimicked by IL-8 treatment and was reverted by incubation with anti-IL8 antibodies.	bisphenol A	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
31546233-8	2019	Interestingly, the action of BPA on SVF cell growth was mimicked by IL-8 treatment and was reverted by incubation with anti-IL8 antibodies.	bisphenol A	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	124-127
31546233-9	2019	All these data suggest that BPA at 0.1nM, a 10 times lower concentration than environmental exposure, increases the expression of pro-inflammatory cytokines via GPR30 both in mature mammary adipocytes and in SVF cells with a possible involvement of IL-8.	bisphenol A	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	249-253
31553301-15	2019	ML1899 enhanced ROS/NO production and up-regulated pro-inflammatory cytokines and chemokine including TNF-alpha, IFN-gamma, IL-6 and IL-8 in macrophages.	A 1899	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
31439713-8	2019	Following IL-8 inhibition with its receptor inhibitor Reparixin or siRNA knockdown, LCSC features of HCC cells were repressed and sensitivity of cells to Sorafenib increased significantly.	Sorafenib	154-163	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
31439713-9	2019	Furthermore, inflammatory cytokines (IL-8, IL-1beta and IL-11) were also up-regulated upon treatment with HCC approved kinase inhibitors Sorafenib and Regorafenib.	Sorafenib	137-146	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
31439713-9	2019	Furthermore, inflammatory cytokines (IL-8, IL-1beta and IL-11) were also up-regulated upon treatment with HCC approved kinase inhibitors Sorafenib and Regorafenib.	regorafenib	151-162	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
31545444-6	2019	Consistently, senescent astrocytic CRT cells induced by D-galactose exhibited increases in the levels of IL-6 and IL-8 via NF-kappaB activation, which are major SASP components and inflammatory cytokines.	Galactose	56-67	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
30611605-6	2019	18F-Sodium fluoride (18F-NaF) is a promising biological tracer that detects microcalcification related to active disease and cellular necrosis within the vessel wall.	18f-sodium fluoride	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
31393642-6	2019	Mechanistically, EVOO phenols counteracts IkappaB degradation and translocation of NF-kappaB to the nucleus, a transcription factor of essential significance to TSLP and IL-8 transcriptional activity; this is evidenced by immunoblotting.	evoo phenols	17-29	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
31214736-6	2019	Besides, IL-8-induced invasion and EMT process of TSCC cells were impeded in the present of the NF-kappaB inhibitor, PDTC or BAY117082.	3-(4-methylphenylsulfonyl)-2-propenenitrile	125-134	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
31437494-10	2019	CBD and dexamethasone treatments reduced the IL-8 level induced by LPS when the cells were treated individually, but showed antagonistic effects when used in combination via MCPIP (monocytic chemotactic protein-induced protein).	Cannabidiol	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
31437494-10	2019	CBD and dexamethasone treatments reduced the IL-8 level induced by LPS when the cells were treated individually, but showed antagonistic effects when used in combination via MCPIP (monocytic chemotactic protein-induced protein).	Dexamethasone	8-21	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
31591201-6	2019	Pretreatment of cultured human microglia from normal adult brains with human recombinant IL-37 (1 to 100 ng/mL) inhibits neurotensin (NT)-stimulated secretion and gene expression of IL-1beta and CXCL8.	Neurotensin	121-132	C-X-C motif chemokine ligand 8	Homo sapiens	195-200
31671764-5	2019	Our results revealed that stybenpropol A reduced soluble intercellular cell adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), interleukin-8 (IL-8), and interleukin-1beta (IL-1beta) expression by ELISA, inhibited apoptosis, and accelerated nitric oxide (NO) release in TNF-alpha-treated HUVECs.	stybenpropol a	26-40	C-X-C motif chemokine ligand 8	Homo sapiens	160-173
31671764-5	2019	Our results revealed that stybenpropol A reduced soluble intercellular cell adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), interleukin-8 (IL-8), and interleukin-1beta (IL-1beta) expression by ELISA, inhibited apoptosis, and accelerated nitric oxide (NO) release in TNF-alpha-treated HUVECs.	stybenpropol a	26-40	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
31476115-7	2019	Our results show that APZ and the known DHCR7 inhibitor, AY9944, increase 7-DHC levels in airway epithelial cells and potentiate O3-induced IL-6 and IL-8 expression and cytokine release.	Aripiprazole	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
31476115-7	2019	Our results show that APZ and the known DHCR7 inhibitor, AY9944, increase 7-DHC levels in airway epithelial cells and potentiate O3-induced IL-6 and IL-8 expression and cytokine release.	trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride	57-63	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
31476115-7	2019	Our results show that APZ and the known DHCR7 inhibitor, AY9944, increase 7-DHC levels in airway epithelial cells and potentiate O3-induced IL-6 and IL-8 expression and cytokine release.	Ozone	129-131	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
31476115-9	2019	Additionally, we find that APZ increases O3-induced IL-6 and IL-8 expression in human nasal epithelial cells from male but not female donors.	Aripiprazole	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
31476115-9	2019	Additionally, we find that APZ increases O3-induced IL-6 and IL-8 expression in human nasal epithelial cells from male but not female donors.	Ozone	41-43	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
31647861-8	2019	Additionally, BITC-induced dying U937 cells released lower levels of chemoattractants, such as IL-8 and MCP-1, when compared to cells undergoing classical apoptosis.	benzyl isothiocyanate	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
31591201-6	2019	Pretreatment of cultured human microglia from normal adult brains with human recombinant IL-37 (1 to 100 ng/mL) inhibits neurotensin (NT)-stimulated secretion and gene expression of IL-1beta and CXCL8.	Neurotensin	134-136	C-X-C motif chemokine ligand 8	Homo sapiens	195-200
31680969-3	2019	In this study, a pH-responsive micelle based on polycaprolactone-block-poly 2-(dimethylamino)ethyl methacrylate (PCL-PDEM) cationic copolymer was developed to carry short interfering RNA (siRNA) for silencing interleukin 8 (IL-8) gene in hepatoma cancer cells.	starch polycaprolactone	48-64	C-X-C motif chemokine ligand 8	Homo sapiens	209-222
31636329-7	2019	Budesonide strongly suppressed the production of neutrophil attractant CXCL8, and promoted epithelial integrity in A549 wild-type cells, while A549 Rho-0 cells displayed reduced corticosteroid sensitivity compared to wild-type cells.	Budesonide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	71-76
31636329-8	2019	The reduced corticosteroid responsiveness may be mediated by glycolytic reprogramming, specifically glycolysis-associated PI3K signaling, as PI3K inhibitor LY294002 restored the sensitivity of CXCL8 secretion to corticosteroids in A549 Rho-0 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	C-X-C motif chemokine ligand 8	Homo sapiens	193-198
31618900-7	2019	In addition to the activation of apoptotic pathways, TRAIL-mediated inflammatory responses were attenuated by GlcN pretreatment reducing nuclear NF-kB levels and the expression of downstream target genes IL-6 and IL-8.	Glucosamine	110-114	C-X-C motif chemokine ligand 8	Homo sapiens	213-217
31532197-6	2019	Moreover, Cu current collector with NaF-PVDF protective layer also delivers good cycle stability at 5 mA cm-2 and ultrahigh DOD (80%).	Copper	10-12	C-X-C motif chemokine ligand 8	Homo sapiens	36-39
31680969-3	2019	In this study, a pH-responsive micelle based on polycaprolactone-block-poly 2-(dimethylamino)ethyl methacrylate (PCL-PDEM) cationic copolymer was developed to carry short interfering RNA (siRNA) for silencing interleukin 8 (IL-8) gene in hepatoma cancer cells.	starch polycaprolactone	48-64	C-X-C motif chemokine ligand 8	Homo sapiens	224-228
31680969-3	2019	In this study, a pH-responsive micelle based on polycaprolactone-block-poly 2-(dimethylamino)ethyl methacrylate (PCL-PDEM) cationic copolymer was developed to carry short interfering RNA (siRNA) for silencing interleukin 8 (IL-8) gene in hepatoma cancer cells.	poly(2-(dimethylamino)ethyl methacrylate)	71-111	C-X-C motif chemokine ligand 8	Homo sapiens	209-222
31680969-3	2019	In this study, a pH-responsive micelle based on polycaprolactone-block-poly 2-(dimethylamino)ethyl methacrylate (PCL-PDEM) cationic copolymer was developed to carry short interfering RNA (siRNA) for silencing interleukin 8 (IL-8) gene in hepatoma cancer cells.	poly(2-(dimethylamino)ethyl methacrylate)	71-111	C-X-C motif chemokine ligand 8	Homo sapiens	224-228
31591378-8	2019	Functional analysis revealed that treatment of transgenic P2Y12+ U937 cells with the receptor agonist 2-MeSADP induced ERK1/2 and Akt phosphorylation and increased the secretion of the chemokines CXCL2, CXCL7, and CXCL8.	methylthio-ADP	102-110	C-X-C motif chemokine ligand 8	Homo sapiens	214-219
31686980-11	2019	Immediately after the marathon race, we observed a negative correlation between IL-8 and daily EI, carbohydrate, fiber, fat, iron, calcium, potassium, and sodium intakes, and higher levels of IL-8 on runners with <3 g/kg/day of carbohydrate intake compared to runners with >5 g/kg/day.	Carbohydrates	99-111	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
31686980-11	2019	Immediately after the marathon race, we observed a negative correlation between IL-8 and daily EI, carbohydrate, fiber, fat, iron, calcium, potassium, and sodium intakes, and higher levels of IL-8 on runners with <3 g/kg/day of carbohydrate intake compared to runners with >5 g/kg/day.	Iron	125-129	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
31686980-11	2019	Immediately after the marathon race, we observed a negative correlation between IL-8 and daily EI, carbohydrate, fiber, fat, iron, calcium, potassium, and sodium intakes, and higher levels of IL-8 on runners with <3 g/kg/day of carbohydrate intake compared to runners with >5 g/kg/day.	Calcium	131-138	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
31686980-11	2019	Immediately after the marathon race, we observed a negative correlation between IL-8 and daily EI, carbohydrate, fiber, fat, iron, calcium, potassium, and sodium intakes, and higher levels of IL-8 on runners with <3 g/kg/day of carbohydrate intake compared to runners with >5 g/kg/day.	Potassium	140-149	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
31686980-11	2019	Immediately after the marathon race, we observed a negative correlation between IL-8 and daily EI, carbohydrate, fiber, fat, iron, calcium, potassium, and sodium intakes, and higher levels of IL-8 on runners with <3 g/kg/day of carbohydrate intake compared to runners with >5 g/kg/day.	Sodium	155-161	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
31686980-11	2019	Immediately after the marathon race, we observed a negative correlation between IL-8 and daily EI, carbohydrate, fiber, fat, iron, calcium, potassium, and sodium intakes, and higher levels of IL-8 on runners with <3 g/kg/day of carbohydrate intake compared to runners with >5 g/kg/day.	Carbohydrates	228-240	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
31545276-10	2019	After GSZD treatment, the adhesive and invasive abilities of MH7A cells were reduced, and secretions of MMPs, IL-6 and IL-8 were also reduced.	gszd	6-10	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
31490211-10	2019	Cannabis-plus-cocaine use increased CRP, IL-8 and IL-6/IL-10 ratio, but decreased thiol content, and inflammatory and activated-classic monocyte percentages.	Cocaine	14-21	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
31377467-6	2019	In in vitro, minocycline reduced cytopathic effects (CPEs), viral protein expressions, viral titers, the levels of interleukin (IL)-6 and IL-8 and relative mRNA expressions of IL-12p40, IL-1beta, and tumor necrosis factor (TNF) after EV71 infection.	Minocycline	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
31377467-7	2019	The levels of TNF, IL-1beta, IL-6, and IL-8 decreased with a single dose of minocycline in EV71-infected THP-1 cells.	Minocycline	76-87	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
31632299-8	2019	Although the promiscuous TAS2R agonists, quinine and denatonium, inhibited the LPS-induced release of TNF-alpha, CCL3 and CXCL8, diphenidol was inactive.	Quinine	41-48	C-X-C motif chemokine ligand 8	Homo sapiens	122-127
31632299-8	2019	Although the promiscuous TAS2R agonists, quinine and denatonium, inhibited the LPS-induced release of TNF-alpha, CCL3 and CXCL8, diphenidol was inactive.	denatonium	53-63	C-X-C motif chemokine ligand 8	Homo sapiens	122-127
31387121-15	2019	CONCLUSION: MK-7 supplementation tended to increase active calcification measured with 18F-NaF PET activity compared with placebo, but no effect was found on conventional CT. Additional research investigating the interpretation of 18F-NaF PET activity is necessary.	vitamin MK 7	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	91-94
31387121-15	2019	CONCLUSION: MK-7 supplementation tended to increase active calcification measured with 18F-NaF PET activity compared with placebo, but no effect was found on conventional CT. Additional research investigating the interpretation of 18F-NaF PET activity is necessary.	vitamin MK 7	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	235-238
31351299-9	2019	Cell-based assays have shown that TBBPA can induce reactive oxygen species in a concentration-dependent manner, and it promotes the production of inflammatory factors such as TNF alpha, IL-6, and IL-8.	tetrabromobisphenol A	34-39	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
31305007-2	2019	Here, the phenomena underlying the adsorption of an anti-human interleukin-8 (anti-IL8) monoclonal antibody (mAb) onto an m-aminophenylboronic acid (m-APBA) ligand in the presence of different mobile-phase modulators (NaF/MgCl 2 /(NH 4 ) 2 SO 4 ) and under different pH values (7.5/8.5/9.0) is investigated.	3-Aminophenylboronic acid	122-147	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
31305007-2	2019	Here, the phenomena underlying the adsorption of an anti-human interleukin-8 (anti-IL8) monoclonal antibody (mAb) onto an m-aminophenylboronic acid (m-APBA) ligand in the presence of different mobile-phase modulators (NaF/MgCl 2 /(NH 4 ) 2 SO 4 ) and under different pH values (7.5/8.5/9.0) is investigated.	3-Aminophenylboronic acid	122-147	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
31305007-2	2019	Here, the phenomena underlying the adsorption of an anti-human interleukin-8 (anti-IL8) monoclonal antibody (mAb) onto an m-aminophenylboronic acid (m-APBA) ligand in the presence of different mobile-phase modulators (NaF/MgCl 2 /(NH 4 ) 2 SO 4 ) and under different pH values (7.5/8.5/9.0) is investigated.	m-apba	149-155	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
31305007-2	2019	Here, the phenomena underlying the adsorption of an anti-human interleukin-8 (anti-IL8) monoclonal antibody (mAb) onto an m-aminophenylboronic acid (m-APBA) ligand in the presence of different mobile-phase modulators (NaF/MgCl 2 /(NH 4 ) 2 SO 4 ) and under different pH values (7.5/8.5/9.0) is investigated.	m-apba	149-155	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
31305007-2	2019	Here, the phenomena underlying the adsorption of an anti-human interleukin-8 (anti-IL8) monoclonal antibody (mAb) onto an m-aminophenylboronic acid (m-APBA) ligand in the presence of different mobile-phase modulators (NaF/MgCl 2 /(NH 4 ) 2 SO 4 ) and under different pH values (7.5/8.5/9.0) is investigated.	m-apba	149-155	C-X-C motif chemokine ligand 8	Homo sapiens	218-221
31305007-2	2019	Here, the phenomena underlying the adsorption of an anti-human interleukin-8 (anti-IL8) monoclonal antibody (mAb) onto an m-aminophenylboronic acid (m-APBA) ligand in the presence of different mobile-phase modulators (NaF/MgCl 2 /(NH 4 ) 2 SO 4 ) and under different pH values (7.5/8.5/9.0) is investigated.	Magnesium Chloride	222-228	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
31305007-2	2019	Here, the phenomena underlying the adsorption of an anti-human interleukin-8 (anti-IL8) monoclonal antibody (mAb) onto an m-aminophenylboronic acid (m-APBA) ligand in the presence of different mobile-phase modulators (NaF/MgCl 2 /(NH 4 ) 2 SO 4 ) and under different pH values (7.5/8.5/9.0) is investigated.	Magnesium Chloride	222-228	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
31305007-2	2019	Here, the phenomena underlying the adsorption of an anti-human interleukin-8 (anti-IL8) monoclonal antibody (mAb) onto an m-aminophenylboronic acid (m-APBA) ligand in the presence of different mobile-phase modulators (NaF/MgCl 2 /(NH 4 ) 2 SO 4 ) and under different pH values (7.5/8.5/9.0) is investigated.	(nh 4 )	230-237	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
31305007-2	2019	Here, the phenomena underlying the adsorption of an anti-human interleukin-8 (anti-IL8) monoclonal antibody (mAb) onto an m-aminophenylboronic acid (m-APBA) ligand in the presence of different mobile-phase modulators (NaF/MgCl 2 /(NH 4 ) 2 SO 4 ) and under different pH values (7.5/8.5/9.0) is investigated.	(nh 4 )	230-237	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
31305007-4	2019	Results show that the adsorption of anti-IL8 mAb to m-APBA is enthalpically driven, corroborating the presence of the reversible esterification reaction between boronic acid or boronates and cis-diol-containing molecules.	m-apba	52-58	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
31305007-4	2019	Results show that the adsorption of anti-IL8 mAb to m-APBA is enthalpically driven, corroborating the presence of the reversible esterification reaction between boronic acid or boronates and cis-diol-containing molecules.	Boronic Acids	161-173	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
31305007-4	2019	Results show that the adsorption of anti-IL8 mAb to m-APBA is enthalpically driven, corroborating the presence of the reversible esterification reaction between boronic acid or boronates and cis-diol-containing molecules.	boronates	177-186	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
31305007-4	2019	Results show that the adsorption of anti-IL8 mAb to m-APBA is enthalpically driven, corroborating the presence of the reversible esterification reaction between boronic acid or boronates and cis-diol-containing molecules.	cis-diol	191-199	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
31444999-14	2019	Ponatinib treatment significantly increased plasma VEGF, soluble (s)VEGFR1, sVEGFR2, sTIE2, interferon gamma (IFNgamma), tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-8, and IL-10 and decreased sVEGFR2.	ponatinib	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
31198997-6	2019	Unlike keratinocytes, normal human fibroblasts expressed high levels of TLR4 mRNA and induced interleukin-8 expression upon stimulation with nickel or cobalt.	Nickel	141-147	C-X-C motif chemokine ligand 8	Homo sapiens	94-107
31198997-6	2019	Unlike keratinocytes, normal human fibroblasts expressed high levels of TLR4 mRNA and induced interleukin-8 expression upon stimulation with nickel or cobalt.	Cobalt	151-157	C-X-C motif chemokine ligand 8	Homo sapiens	94-107
31247373-6	2019	The influence of selected TLR7 agonists on cytokine production is also reported showing that N-cyclopropyl-2-(trifluoromethyl)quinazolin-4-amine (46) is able to induce increased levels of IL-6 and IL-8.	n-cyclopropyl-2-(trifluoromethyl)quinazolin-4-amine	93-144	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
31220426-11	2019	RESULTS: Overall Mo from control subjects exposed to ASA showed increased secretion of IL-1RA, IL-8, MCP-1, and TNF-alpha and Mo from stroke patients showed greater release of IL-1RA and MCP-1.	Aspirin	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
31220426-13	2019	In addition, in co-cultures independent of Mo origin, ASA reduced IL-6, IL-8, MCP-1, and TNF-alpha.	Aspirin	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
29703573-0	2019	IL-8 negatively regulates ABCA1 expression and cholesterol efflux via upregulating miR-183 in THP-1 macrophage-derived foam cells.	Cholesterol	47-58	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
29703573-1	2019	OBJECTIVE: Previous studies suggest that IL-8 has an important role in the regulation of cholesterol efflux, but whether miRNAs are involved in this process is still unknown.	Cholesterol	89-100	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
29703573-2	2019	The purpose of this study is to explore whether IL-8 promotes cholesterol accumulation by enhancing miR-183 expression in macrophages and its underlying mechanism.	Cholesterol	62-73	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
29703573-3	2019	METHODS AND RESULTS: Treatment of THP-1 macrophage-derived foam cells with IL-8 decreased ABCA1 expression and cholesterol efflux.	Cholesterol	111-122	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
29703573-7	2019	Cholesterol transport assays confirmed that IL-8 dramatically inhibited apolipoprotein AI-mediated ABCA1-dependent cholesterol efflux by increasing miR-183 expression.	Cholesterol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
29703573-7	2019	Cholesterol transport assays confirmed that IL-8 dramatically inhibited apolipoprotein AI-mediated ABCA1-dependent cholesterol efflux by increasing miR-183 expression.	Cholesterol	115-126	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
29703573-9	2019	CONCLUSION: IL-8 enhances the expression of miR-183, which then inhibits ABCA1 expression and cholesterol efflux.	Cholesterol	94-105	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
31172286-3	2019	Therefore, we introduce a new technique to assess graft viability using 18F-sodium fluoride (18F-NaF) PET-CT for femoral allografts in reverse total shoulder arthroplasty (RSA).	18f-sodium fluoride	72-91	C-X-C motif chemokine ligand 8	Homo sapiens	97-100
31165327-10	2019	In conclusion, combination of resveratrol and silymarin could significantly inhibit inflammatory effects of histamine on cultured HGFs by reduction of IL-6, IL-8, TPA-1, and TNF-alpha.	Resveratrol	30-41	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
31065104-7	2019	The Spearman correlation test showed that the concentration of IL-8 in the aqueous humor was significantly associated with the aqueous level of Cu (p = 0.009, r = 0.646) and Se (p = 0.031, r = 0.558).	Copper	144-146	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
31517562-7	2019	Fluticasone propionate (FP) and dexamethasone (DEX) suppressed IL-6 and IL-8 production in BEAS-2B cells, but clarithromycin (CAM) failed to do so.	Fluticasone	0-22	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
31517562-7	2019	Fluticasone propionate (FP) and dexamethasone (DEX) suppressed IL-6 and IL-8 production in BEAS-2B cells, but clarithromycin (CAM) failed to do so.	Fluticasone	24-26	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
31517562-7	2019	Fluticasone propionate (FP) and dexamethasone (DEX) suppressed IL-6 and IL-8 production in BEAS-2B cells, but clarithromycin (CAM) failed to do so.	Dexamethasone	32-45	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
31517562-7	2019	Fluticasone propionate (FP) and dexamethasone (DEX) suppressed IL-6 and IL-8 production in BEAS-2B cells, but clarithromycin (CAM) failed to do so.	Dexamethasone	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
31165327-10	2019	In conclusion, combination of resveratrol and silymarin could significantly inhibit inflammatory effects of histamine on cultured HGFs by reduction of IL-6, IL-8, TPA-1, and TNF-alpha.	Silymarin	46-55	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
31165327-10	2019	In conclusion, combination of resveratrol and silymarin could significantly inhibit inflammatory effects of histamine on cultured HGFs by reduction of IL-6, IL-8, TPA-1, and TNF-alpha.	Histamine	108-117	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
31049957-7	2019	RESULTS: Production of IL-6, IL-8, MCP-1, and OPG was significantly increased by Poly I:C or Pam3CSK4 to a similar extent.	Poly I-C	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
31593984-5	2019	Results: Treatment with curcumin resulted in a dose- and time-dependent decrease in IL-1beta-induced synthesis of inflammatory cytokines, including IL-6, IL-8, MCP-1, and ICAM-1 at both mRNA and protein levels.	Curcumin	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
31001928-10	2019	This study suggests that PBM accelerates tooth movement during molar intrusion, due to modulation of IL-6, IL-8 and IL-1beta during bone remodeling.	pbm	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
31579207-0	2019	Diffuse Skeletal Uptake on 18F-Fluoro-2-Deoxy-d-glucose Positron Emission Tomography/Computed Tomography Scan in a Patient with Acute Lymphoblastic Leukemia: A Typical Superscan Pattern Resembling NaF Positron Emission Tomography Scan.	4-fluoro-4-deoxyglucose	27-55	C-X-C motif chemokine ligand 8	Homo sapiens	197-200
31584250-6	2019	AOH significantly reduces IL-1beta transcription after 5 h but shows an increasing tendency on IL-8 transcript levels after long-term exposure (20 h).	alternariol	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
30772226-1	2019	OBJECTIVES: This study aimed to assess the association between increased lesion peri-coronary adipose tissue (PCAT) density and coronary 18F-sodium fluoride (18F-NaF) uptake on positron emission tomography (PET) in stable patients with high-risk coronary plaques (HRPs) shown on coronary computed tomography angiography (CTA).	18f-sodium fluoride	137-156	C-X-C motif chemokine ligand 8	Homo sapiens	162-165
30772226-10	2019	Lesions with 18F-NaF uptake had higher surrounding PCAT density than those without 18F-NaF uptake (-73 HU; interquartile range -79 to -68 vs. -86 HU; interquartile range -94 to -80 HU; p &lt; 0.001).	Fluorine-18	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
31584250-7	2019	In IL-1beta-stimulated cells, AOH (20-40 microm) augments TNF-alpha transcripts while repressing IL-8, IL-6, and IL-1beta transcription as well as IL-8 secretion.	alternariol	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
31584250-7	2019	In IL-1beta-stimulated cells, AOH (20-40 microm) augments TNF-alpha transcripts while repressing IL-8, IL-6, and IL-1beta transcription as well as IL-8 secretion.	alternariol	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
31363829-7	2019	Among the entire patient population, SUA levels significantly increased 3 months after starting treatment with TNFis (279.5 [84.0] vs. 299.0 [102.0] mumol/l, p &lt; 0.0001), while the levels of CRP, IL-6, IL-8, and MCP-1 significantly decreased.	sua	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	205-209
31348843-12	2019	Galiellalactone reduced the levels of IL8 and granulocyte macrophage-colony stimulating factor in prostate cancer cells per se.	galiellalactone	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
31569368-6	2019	In addition, PhIP-mediated PTHrP up-regulated as well as increased IL-8 secretion in 786-O cells, and then contributed to 786-O-mediated bone resorption.	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
30676542-1	2019	OBJECTIVE: The main objectives of this article were to assess the effect of preoperative transdermal fentanyl patch (TFP) on interleukin (IL)-6 and IL-8 levels and pain after laparoscopic cholecystectomy.	Fentanyl	101-109	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
31430501-6	2019	GNP-HCIm significantly inhibited proliferation and viability inducing apoptosis of LFs and effectively reduced IL-8 release, viability and M2 polarization in alveolar macrophages.	gnp-hcim	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
31048000-14	2019	The COX-2 specific celecoxib was identified as the most potent drug to reduce IL-6, IL-8 and TNF-alpha formation after SM exposures in vitro.	Celecoxib	19-28	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
31557846-5	2019	The transported polyphenols were able to prevent IL-8 production and suppress the gene expression of proinflammatory mediators (TNF-alpha, ICAM-1, VCAM-1, and COX-2) in the TNF-alpha or oxidized low-density lipoprotein (ox-LDL) treated EA.hy926 cells.	Polyphenols	16-27	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
31620139-9	2019	Within Bangladeshi 1-year-olds, stunting (as measured by height-for-age z-scores) was found to be associated with IL-8 and TGFbeta expression in PMA-ionomycin stimulated samples.	Ionomycin	145-158	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
31407890-7	2019	Concentrations of interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor-alpha in macrophage supernatant increased following 100 mug/mL silica exposure for 24 h. Treatment of AMs with 500 muM FAC decreased both oxidant generation and cytokine release associated with silica exposure, supporting a dependence of these effects on sequestration of cell metal by the particle surface.	Silicon Dioxide	143-149	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
31548589-11	2019	The immunomodulatory role of histamine on CCL2 and CXCL8 was detected at the transcript and protein levels.	Histamine	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	51-56
31482532-1	2021	BACKGROUND: Uptake of 18F-sodium fluoride (18F-NaF) on positron emission tomography (PET) reflects active calcification.	18f-sodium fluoride	22-41	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
31059760-7	2019	Compared to the treatment with LPS only, LPS/APAP co-exposures induced the production of interleukin (IL)-8, a pro-inflammatory cytokine, but suppressed the secretion of IL-6, a cytokine regulating hepatic regeneration, along with the increase in APAP dosages.	Acetaminophen	45-49	C-X-C motif chemokine ligand 8	Homo sapiens	89-107
31411318-5	2019	In this study, we treated hESCs with lipopolysaccharide (LPS) and found that LPS treatment increased the mRNA levels of pro-inflammatory cytokines, such as interleukin (IL)-1beta, IL-6, IL-8, IL-18, and TNFalpha, and the secretion of IL-6.	hescs	26-31	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
31488175-1	2019	INTRODUCTION: In prostate cancer patients, imaging of bone metastases is enhanced through the use of sodium fluoride positron emission tomography (18F-NaF PET/CT).	Sodium Fluoride	101-116	C-X-C motif chemokine ligand 8	Homo sapiens	151-154
31488175-3	2019	In this work, 18F-NaF PET/CT was investigated for response assessment to single fraction stereotactic ablative body radiotherapy (SABR) to bone metastases in prostate cancer patients.	sabr	130-134	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
31488175-13	2019	CONCLUSION: 18F-NaF PET/CT for response assessment of bone metastases to single fraction SABR indicates high rates of reduction of osteoblastic activity in the tumour and non-tumour bone receiving high doses.	sabr	89-93	C-X-C motif chemokine ligand 8	Homo sapiens	16-19
31540059-11	2019	HT29/C1 colonic epithelial cells treated with zerumbone suppressed BFT-induced NF-kappaB signaling and IL-8 secretion.	zerumbone	46-55	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
31491033-8	2019	An enzyme-linked immunosorbent assay (ELISA)-based cytokine array identified interleukin (IL)-6 and IL-8, which show pleiotropic regulatory effects on lung cancer cells, to be specifically produced in higher amounts by the three types of asbestos-exposed lung fibroblasts than normal lung fibroblasts.	Asbestos	238-246	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
30861304-2	2019	Previously, we have shown that silica nanoparticles sized 50 nm (Si50) induce release of CXCL8 and IL-6 from BEAS-2B cells, via mechanisms involving NFkappaB, p38 MAP kinase and TGF-alpha-activated EGF receptor.	Silicon Dioxide	31-37	C-X-C motif chemokine ligand 8	Homo sapiens	89-94
30565018-2	2019	Accumulating evidence demonstrates that vitamin C administration ameliorate sodium fluoride (NaF)-induced oxidative stress.	Ascorbic Acid	40-49	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
30861304-3	2019	In the present study, the role of ROS-mediated mechanisms in the concentration-dependent Si50 induction of CXCL8 and IL-6 responses was examined.	Reactive Oxygen Species	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	107-112
30565018-2	2019	Accumulating evidence demonstrates that vitamin C administration ameliorate sodium fluoride (NaF)-induced oxidative stress.	Sodium Fluoride	76-91	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
30565018-3	2019	However, the potentially beneficial effects of vitamin C against NaF-induced cytotoxicity and the underlying molecular mechanisms of this protection are not fully understood.	Ascorbic Acid	47-56	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
30861304-5	2019	Pre-treatment with the ROS inhibitors N-acetyl cysteine (NAC) and diphenyleneiodonium (DPI) partially attenuated CXCL8 and IL-6 responses to 200 microg/mL, but not to 100 microg/mL Si50.	Reactive Oxygen Species	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	113-118
30565018-4	2019	Here, we found that NaF stimulated cytotoxicity, increased mitochondrial reactive oxygen species (mROS) production, and induced apoptosis in F9 embryonic carcinoma cells.	Reactive Oxygen Species	73-96	C-X-C motif chemokine ligand 8	Homo sapiens	20-23
30565018-4	2019	Here, we found that NaF stimulated cytotoxicity, increased mitochondrial reactive oxygen species (mROS) production, and induced apoptosis in F9 embryonic carcinoma cells.	mros	98-102	C-X-C motif chemokine ligand 8	Homo sapiens	20-23
30565018-6	2019	However, all NaF-induced mitochondrial oxidative injuries were efficiently ameliorated by overexpression of Sirt1 or incubation with Mito-TEMPO (a SOD2 mimetic).	MitoTEMPO	133-143	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
30565018-7	2019	Moreover, pretreatment with vitamin C enhanced the expression of Sirt1 and decreased NaF-induced mitochondrial oxidative stress and apoptosis.	Ascorbic Acid	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
30861304-5	2019	Pre-treatment with the ROS inhibitors N-acetyl cysteine (NAC) and diphenyleneiodonium (DPI) partially attenuated CXCL8 and IL-6 responses to 200 microg/mL, but not to 100 microg/mL Si50.	Acetylcysteine	38-55	C-X-C motif chemokine ligand 8	Homo sapiens	113-118
30565018-10	2019	In summary, our data indicate that Sirt1 plays a pivotal role in the ability of vitamin C to stimulate SOD2 activity and attenuate mitochondrial oxidative stress, which partially through vitamin C receptor in NaF-induced F9 cells injury.	Ascorbic Acid	80-89	C-X-C motif chemokine ligand 8	Homo sapiens	209-212
30861304-5	2019	Pre-treatment with the ROS inhibitors N-acetyl cysteine (NAC) and diphenyleneiodonium (DPI) partially attenuated CXCL8 and IL-6 responses to 200 microg/mL, but not to 100 microg/mL Si50.	Acetylcysteine	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	113-118
30565018-10	2019	In summary, our data indicate that Sirt1 plays a pivotal role in the ability of vitamin C to stimulate SOD2 activity and attenuate mitochondrial oxidative stress, which partially through vitamin C receptor in NaF-induced F9 cells injury.	Ascorbic Acid	187-196	C-X-C motif chemokine ligand 8	Homo sapiens	209-212
30861304-5	2019	Pre-treatment with the ROS inhibitors N-acetyl cysteine (NAC) and diphenyleneiodonium (DPI) partially attenuated CXCL8 and IL-6 responses to 200 microg/mL, but not to 100 microg/mL Si50.	diphenyleneiodonium	66-85	C-X-C motif chemokine ligand 8	Homo sapiens	113-118
30861304-5	2019	Pre-treatment with the ROS inhibitors N-acetyl cysteine (NAC) and diphenyleneiodonium (DPI) partially attenuated CXCL8 and IL-6 responses to 200 microg/mL, but not to 100 microg/mL Si50.	diphenyleneiodonium	87-90	C-X-C motif chemokine ligand 8	Homo sapiens	113-118
30861304-10	2019	In conclusion, Si50-induced CXCL8 and IL-6 involved both ROS-dependent and ROS-independent mechanisms.	Reactive Oxygen Species	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	28-33
31211861-7	2019	The results showed that esculetin suppressed histamine-induced expression and secretion of IL-6, IL-8, and MUC5AC in HNEpCs.	esculetin	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
30767875-12	2019	Cerulenin repressed the expressions of IL-6, CCL20 and IL-8 in RASFs stimulated by LTF.	Cerulenin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
31211861-7	2019	The results showed that esculetin suppressed histamine-induced expression and secretion of IL-6, IL-8, and MUC5AC in HNEpCs.	Histamine	45-54	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
31211861-10	2019	Inhibiting NF-kappaB pathway suppressed histamine-induced production of IL-6, IL-8, and MUC5AC in HNEpCs.	Histamine	40-49	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
31233937-6	2019	In this study, we report that LPA markedly enhanced IL-6 and CXCL15 (mouse homologue of human IL-8) production in MLO-Y4 cells and that this enhancement was suppressed by the LPA1/3-selective antagonist Ki16425, the Gi/o protein inhibitor PTX or the protein kinase C (PKC) inhibitor sotrastaurin.	lysophosphatidic acid	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
31252119-4	2019	Moreover, ROS accelerate the translocation and phosphorylation of NF-kappaB in nucleic and promote the expression of inflammatory, such as IL-8 and IL-6.	Reactive Oxygen Species	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
31441829-2	2019	METHODS: Comfilcon A, balafilcon A, omafilcon A, and etafilcon A were soaked in 500 and 100 pg/mL of interleukin-8 (IL-8), matrix metalloproteinase-9 (MMP-9), or interleukin-1 receptor antagonist (IL-1Ra), and also in combined solutions of inflammatory mediators (500 pg/mL or 100 pg/mL) separately.	etafilcon	53-64	C-X-C motif chemokine ligand 8	Homo sapiens	101-114
31441829-8	2019	There were no differences in IL-8 absorption between lenses; however, more IL-8 remained firmly bound to omafilcon A (P=0.01; 336+-25 pg/mL) than etafilcon A (106+-133 pg/mL) when soaked in 500 pg/mL.	omafilcon a	105-116	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
30692654-11	2019	Tamoxifen decreased breast tissue levels of IL-8 and IL-18.	Tamoxifen	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
31441829-10	2019	When the mediators were combined, IL-8 was absorbed more in etafilcon A (P=0.03) than in other lens materials, but the absorbed IL-8 did not remain firmly bound.	etafilcon	60-71	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
31233937-6	2019	In this study, we report that LPA markedly enhanced IL-6 and CXCL15 (mouse homologue of human IL-8) production in MLO-Y4 cells and that this enhancement was suppressed by the LPA1/3-selective antagonist Ki16425, the Gi/o protein inhibitor PTX or the protein kinase C (PKC) inhibitor sotrastaurin.	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid	203-210	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
31233937-6	2019	In this study, we report that LPA markedly enhanced IL-6 and CXCL15 (mouse homologue of human IL-8) production in MLO-Y4 cells and that this enhancement was suppressed by the LPA1/3-selective antagonist Ki16425, the Gi/o protein inhibitor PTX or the protein kinase C (PKC) inhibitor sotrastaurin.	ptx	239-242	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
31233937-6	2019	In this study, we report that LPA markedly enhanced IL-6 and CXCL15 (mouse homologue of human IL-8) production in MLO-Y4 cells and that this enhancement was suppressed by the LPA1/3-selective antagonist Ki16425, the Gi/o protein inhibitor PTX or the protein kinase C (PKC) inhibitor sotrastaurin.	sotrastaurin	283-295	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
31299413-3	2019	We now show mechanistically that EC activation induces the secretion of interleukin-8 (IL-8) leading to significant expansion of non-adherent AML cells and resistance to cytarabine (Ara-C).	Cytarabine	182-187	C-X-C motif chemokine ligand 8	Homo sapiens	72-85
31009103-5	2019	Eriodictyol significantly reduced RA-FLS secretion of tumor necrosis factor alpha, interleukin 6 (IL-6), IL-8, and IL-1beta.	eriodictyol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
32821713-1	2019	Objective: The objective of this study was to analyze uptake patterns and intensity of 18F-fluorodeoxyglucose (FDG) and 18F-sodium fluoride (NaF) radioligands in carotid atheroma among stroke patients according to carotid atheroma characteristics.	18f-sodium fluoride	120-139	C-X-C motif chemokine ligand 8	Homo sapiens	141-144
32821713-6	2019	FDG uptake at symptomatic carotid arteries was significantly more increased than that at asymptomatic arteries (TBR: 1.17+-0.23 vs. 1.01+-0.15, Mann-Whitney U-test, p=0.02), but NaF uptake was not different (TBR: 1.38+-0.49 vs. 1.51+-0.40, p=0.40).	Fluorodeoxyglucose F18	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	178-181
31299413-3	2019	We now show mechanistically that EC activation induces the secretion of interleukin-8 (IL-8) leading to significant expansion of non-adherent AML cells and resistance to cytarabine (Ara-C).	Cytarabine	170-180	C-X-C motif chemokine ligand 8	Homo sapiens	72-85
31299413-3	2019	We now show mechanistically that EC activation induces the secretion of interleukin-8 (IL-8) leading to significant expansion of non-adherent AML cells and resistance to cytarabine (Ara-C).	Cytarabine	182-187	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
31299413-3	2019	We now show mechanistically that EC activation induces the secretion of interleukin-8 (IL-8) leading to significant expansion of non-adherent AML cells and resistance to cytarabine (Ara-C).	Cytarabine	170-180	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
31452801-12	2019	Reverse transcription-quantitative PCR analysis performed on docetaxel-sensitive and docetaxel-resistant prostate cancer cell lines demonstrated that certain hub genes, including CDK1, 2"-5"-oligoadenylate synthetase 3, CXCL8 and CDH1, were highly expressed in the docetaxel-resistant cell lines, which confirmed the bioinformatics results.	Docetaxel	85-94	C-X-C motif chemokine ligand 8	Homo sapiens	220-225
31283028-10	2019	There was a significant decrease in the serum interleukin-8(IL-8), interleukin-4(IL-4), and eotaxin levels following 3 weeks of clarithromycin therapy.	Clarithromycin	128-142	C-X-C motif chemokine ligand 8	Homo sapiens	46-59
31283028-10	2019	There was a significant decrease in the serum interleukin-8(IL-8), interleukin-4(IL-4), and eotaxin levels following 3 weeks of clarithromycin therapy.	Clarithromycin	128-142	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
31283028-12	2019	The macrolides may reduce the IL-8 levels in the airway and plasma, but failed to demonstrate an antiviral effect in children with bronchiolitis.	Macrolides	4-14	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
31349755-7	2019	Cytochalasin D and amiloride treatment of differentiated THP-1 cells reduced cell-associated MWCNTs and IL-8 induction.	Amiloride	19-28	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
31452801-12	2019	Reverse transcription-quantitative PCR analysis performed on docetaxel-sensitive and docetaxel-resistant prostate cancer cell lines demonstrated that certain hub genes, including CDK1, 2"-5"-oligoadenylate synthetase 3, CXCL8 and CDH1, were highly expressed in the docetaxel-resistant cell lines, which confirmed the bioinformatics results.	Docetaxel	61-70	C-X-C motif chemokine ligand 8	Homo sapiens	220-225
31452801-12	2019	Reverse transcription-quantitative PCR analysis performed on docetaxel-sensitive and docetaxel-resistant prostate cancer cell lines demonstrated that certain hub genes, including CDK1, 2"-5"-oligoadenylate synthetase 3, CXCL8 and CDH1, were highly expressed in the docetaxel-resistant cell lines, which confirmed the bioinformatics results.	Docetaxel	85-94	C-X-C motif chemokine ligand 8	Homo sapiens	220-225
31480533-9	2019	The produced EGCG microparticles reduced the expression of inflammatory (IL-6, IL-8, COX-2) and catabolic (MMP1, MMP3, MMP13) mediators in pro-inflammatory 3D cell cultures.	epigallocatechin gallate	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
31543817-10	2019	The muscarinic receptor antagonist (MRA) tiotropium, but not aclidinium, caused minor inhibition of the endotoxin-induced release of IL-26 and IL-8, paralleled by a decreased phosphorylation of NF-kappaB.	tiotropium	41-51	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
31543817-9	2019	The glucocorticoid hydrocortisone caused substantial inhibition of the endotoxin-induced release of IL-26, IL-6, and IL-8, an effect paralleled by a decrease of the phosphorylation of NF-kappaB, p38, and ERK1/2.	Hydrocortisone	19-33	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
30542936-10	2019	Additionally, before sleep nNO was also positively associated with IL-6 (r = 0.586, p = 0.005) and IL-8 (r = 0.520, p = 0.016) concentration.	Nitrous Oxide	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
31480284-0	2019	Disruption of the NF-kappaB/IL-8 Signaling Axis by Sulconazole Inhibits Human Breast Cancer Stem Cell Formation.	sulconazole	51-62	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
31480284-5	2019	Sulconazole inhibited mammosphere formation, reduced the protein level of nuclear NF-kappaB, and reduced extracellular IL-8 levels in mammospheres.	sulconazole	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
31480284-7	2019	Sulconazole reduced nuclear NF-kappaB protein levels and secreted IL-8 levels in mammospheres.	sulconazole	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
31480284-8	2019	These new findings show that sulconazole blocks the NF-kappaB/IL-8 signaling pathway and CSC formation.	sulconazole	29-40	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
31469844-4	2019	RESULTS: AL tissues had elevated levels of TNF-family members sTNFR2, TNFSF14, sFasL, sBAFF, cytokines/chemokines IL8, CCL2, IL1RA/IL36, sIL6R, and growth factors sAREG, CSF1, comparing to non-AL.	Aluminum	9-11	C-X-C motif chemokine ligand 8	Homo sapiens	114-117
31543817-11	2019	The beta2-adrenoceptor agonist salbutamol caused modest inhibition of the endotoxin-induced release of IL-26 and IL-8, paralleled by a decreased phosphorylation of NF-kappaB, JNK1-3, and p38.	Albuterol	31-41	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
31531360-8	2019	Our results demonstrated that quercetin inhibited the LPS-induced production of IL-1beta, IL-6, IL-8, and TNF-alpha in a dose-dependent manner.	Quercetin	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
31429784-15	2019	Expression of CXCL1 and IL-8 in human endothelial cells was enhanced by LPA, but was inhibited by LA-01.	lysophosphatidic acid	72-75	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
31534438-6	2019	We found that poly I:C induced increased expression of the proinflammatory cytokines IL1beta, IL6, CXCL8, and TNF and IFN-beta1 in AECs from both control subjects and COPD patients.	Poly I-C	14-22	C-X-C motif chemokine ligand 8	Homo sapiens	99-104
31443599-0	2019	TNF-alpha in Combination with Palmitate Enhances IL-8 Production via The MyD88- Independent TLR4 Signaling Pathway: Potential Relevance to Metabolic Inflammation.	Palmitates	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
31443599-5	2019	We found that co-stimulation of human monocytes with palmitate and TNF-alpha led to increased IL-8 production as compared to those stimulated with palmitate or TNF-alpha alone.	Palmitates	53-62	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
31443599-11	2019	These findings suggest that the signaling cross-talk between saturated fatty acid palmitate and TNF-alpha may be a key driver in obesity-associated chronic inflammation via an excessive production of IL-8.	saturated fatty acid palmitate	61-91	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
31531360-11	2019	In conclusion, these results suggested that quercetin attenuated the production of IL-1beta, IL-6, IL-8, and TNF-alpha in P. gingivalis LPS-treated HGFs by activating PPAR-gamma which subsequently suppressed the activation of NF-kappaB.	Quercetin	44-53	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
31429784-15	2019	Expression of CXCL1 and IL-8 in human endothelial cells was enhanced by LPA, but was inhibited by LA-01.	la-01	98-103	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
31409858-0	2019	DF2726A, a new IL-8 signalling inhibitor, is able to counteract chemotherapy-induced neuropathic pain.	df2726a	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
31415645-9	2019	Finally, a combined panel of IL-8, IL-15 and gender demonstrated diagnostic accuracy (AUC = 0.830, p &lt; 0.0001) in distinguishing PDAC in the presence of jaundice from benign controls with either jaundice, choledocholithiasis or common bile duct injury.	pdac	132-136	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
31313775-4	2019	The calculated results for the ionic structure indicate that molten 1.3(KF + NaF)-AlF3 electrolytes have a high ionic polymerization degree, which is unfavorable for the transport properties of low-temperature 1.3(KF + NaF)-AlF3 electrolytes.	lysylphenylalanine	72-74	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
31313775-4	2019	The calculated results for the ionic structure indicate that molten 1.3(KF + NaF)-AlF3 electrolytes have a high ionic polymerization degree, which is unfavorable for the transport properties of low-temperature 1.3(KF + NaF)-AlF3 electrolytes.	lysylphenylalanine	72-74	C-X-C motif chemokine ligand 8	Homo sapiens	219-222
31409858-4	2019	Exposure to oxaliplatin triggers alterations in peripheral neuropathic pathways previously linked to IL-8 pathway.	Oxaliplatin	12-23	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
31409858-5	2019	We investigated a novel selective inhibitor of IL-8 receptors, DF2726A, and showed its effects in counteracting CINP pathways, extending the relevance of the activation of IL-8 pathway to the class of platinum chemotherapeutics.	df2726a	63-70	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
31399091-11	2019	In sputum, compared with placebo both CHF6001 doses significantly decreased leukotriene B4, C-X-C motif chemokine ligand 8, macrophage inflammatory protein 1beta, matrix metalloproteinase 9, and tumour necrosis factor alpha (TNFalpha).	3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide	38-45	C-X-C motif chemokine ligand 8	Homo sapiens	76-161
31447857-7	2019	The P2Y11 receptor agonist ATPgammaS and NAD+ could independently stimulate the production of IL-8 in M2 macrophages, however, only the ATPgammaS-induced response was mediated by P2Y11 receptor.	adenosine 5'-O-(3-thiotriphosphate)	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
31447857-7	2019	The P2Y11 receptor agonist ATPgammaS and NAD+ could independently stimulate the production of IL-8 in M2 macrophages, however, only the ATPgammaS-induced response was mediated by P2Y11 receptor.	NAD	41-45	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
30884982-8	2019	Travatan and Lumigan 0.03% increased concentrations of Interleukin (IL)-6 and IL-8 in culture media.	Travoprost	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
30905242-1	2019	Objective: The objective of this study was to compare the remineralizing effect of sodium fluoride (NaF) mouth rinse or NaF gel as an adjunct to NaF dentifrice on incipient caries-like lesions in an in situ cross-over design study, with three sessions of 30 days each.	Sodium Fluoride	83-98	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
30874442-5	2019	Key contributions from COPDGene include identification of DNA methylation effects from smoking and genetic variation, new transcriptomic signatures in the blood, identification of protein biomarkers associated with severity and progression (e.g., sRAGE [soluble receptor for advanced glycosylation end products], inflammatory cytokines IL-6 and IL-8), and identification of small molecules (ceramides and sphingomyelin) that may be pathogenic.	copdgene	23-31	C-X-C motif chemokine ligand 8	Homo sapiens	345-349
30690929-7	2019	The study demonstrated a correlation between venular retinal blood oxygen saturation and proangiogenic factors HGF (r = 0.558, p = 0.038), Ang2 (r = 0.556, p = 0.039) and EGF (r = -0.554, p = 0.040), but did not find any correlation for IL-8 (r = 0.330, p = 0.249) even though this biomarker was significantly higher in the diabetic group.	Oxygen	67-73	C-X-C motif chemokine ligand 8	Homo sapiens	237-241
31211863-11	2019	An increased mRNA expression of IL-6, IL-8, and MCP-1 by FAEEs is key finding to suggest a metabolic basis of EtOH-induced inflammatory response.	Ethanol	110-114	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
30884982-8	2019	Travatan and Lumigan 0.03% increased concentrations of Interleukin (IL)-6 and IL-8 in culture media.	Bimatoprost	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
31005727-8	2019	In presence of OSCC an increased concentration of IL-8(p = 0.004), IL-6(p = 0.005), VEGF(p = 0.014), MIP-1ss(p = 0.033), IP-10(p = 0.047), IL-1beta(p = 0.049) was observed; conversely the concentration of IFN-gamma(p = 0.036) and IL-5(P = 0.048) decreased.	oscc	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
31172435-5	2019	Among the three types of SOA, m-xylene-derived SOA showed the strongest induction of the HMOX1 and IL8 genes, and transcriptional activity via the antioxidant response element (ARE).	Xylenes	32-38	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
30902292-3	2019	In addition, the glycated TM by glucose, maltotriose, maltopentaose and maltoheptaose inhibited the proliferation and IL-8 secretion of Caco-2, and the CD63 and CD203c expression, MAPK signaling of KU812 basophils, while the glycated TM by maltose had insignificant suppression on the allergy reactivities of Caco-2 cells and KU812 basophils.	Glucose	32-39	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
30902292-3	2019	In addition, the glycated TM by glucose, maltotriose, maltopentaose and maltoheptaose inhibited the proliferation and IL-8 secretion of Caco-2, and the CD63 and CD203c expression, MAPK signaling of KU812 basophils, while the glycated TM by maltose had insignificant suppression on the allergy reactivities of Caco-2 cells and KU812 basophils.	maltotriose	41-52	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
30902292-3	2019	In addition, the glycated TM by glucose, maltotriose, maltopentaose and maltoheptaose inhibited the proliferation and IL-8 secretion of Caco-2, and the CD63 and CD203c expression, MAPK signaling of KU812 basophils, while the glycated TM by maltose had insignificant suppression on the allergy reactivities of Caco-2 cells and KU812 basophils.	maltoheptaose	72-85	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
30971437-6	2019	IPE supplementation decreased proinflammatory interleukin-8 levels compared with cellulose, while inulin had no impact on the systemic inflammatory markers studied.	ipe	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	46-59
30472681-8	2019	In humans, preoperative administration of prucalopride, but not of VNS, decreased Il6 and Il8 expression in the muscularis externa and improved clinical recovery.	prucalopride	42-54	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
30738171-10	2019	GBR 830 induced significant progressive reductions in TH1 (IFN-gamma/CXCL10), TH2 (IL-31/CCL11/CCL17), and TH17/TH22 (IL-23p19/IL-8/S100A12) mRNA expression in lesional skin.	gbr 830	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
31356535-12	2019	The IL-6 and IL-8 concentrations in the DEX group were dramatically increased at 6 hours after CPB (P < 0.05).	Dexmedetomidine	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
31017309-7	2019	A significant (P &lt; 0.05) release of interleukin-8 was observed after Ap exposure to ZnO NPs at 100 mug/mL and after Bl exposure to sono ZnO NPs at 100 mug/mL.	Zinc Oxide	87-90	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
30558829-11	2019	SB203580 showed little effect on IL-1beta-induced sICAM-1 secretion, but effectively inhibited its induction of IL-8 secretion in pulp cells.	SB 203580	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
31313790-5	2019	Exposure to As(iii) and As(v) generates an increase in the release of the pro-inflammatory cytokine IL-8 (57-1135%) and an increase in the generation of reactive oxygen and/or nitrogen species (130-340%) in both cell lines.	Arsenic	12-14	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
31158307-0	2019	Human alpha defensins promote the expression of the inflammatory cytokine interleukin-8 under high-glucose conditions: Novel insights into the poor healing of diabetic foot ulcers.	Glucose	99-106	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
30515817-5	2019	IL-6 and IL-8 upregulation were blocked by broad-acting HDAC inhibitors SAHA and LBH589.	Panobinostat	81-87	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
31112773-2	2019	We analyzed impact of this diversity, in relation to carriage and expression of cytholethal distending toxin B (cdtB), on alteration of IL-8, TNF-alpha, TLR2, TLR4, TLR5, CASP3 mRNA and cytokine levels in HT-29 cell line.	cytholethal	80-91	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
31272325-2	2019	Two tracers of recent interest for carotid plaque imaging are 18F-fluorodeoxyglucose (18F-FDG) and 18F-sodium fluoride (18F-NaF).	18f-sodium fluoride	99-118	C-X-C motif chemokine ligand 8	Homo sapiens	124-127
31456857-1	2019	Purpose: To determine the utility of 18F-sodium fluoride positron emission tomography-computed tomography (18F-NaF PET/CT) in the imaging assessment of therapy response in men with osseous-only metastatic prostate cancer.	18f-sodium fluoride	37-56	C-X-C motif chemokine ligand 8	Homo sapiens	111-114
30919009-11	2019	alpha-ZOL + beta-ZOL showed antagonistic effects on inflammation for IL-1beta and TNF-alpha, but act synergic for IL-8 at high toxin concentrations.	zearalenol	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
30919009-11	2019	alpha-ZOL + beta-ZOL showed antagonistic effects on inflammation for IL-1beta and TNF-alpha, but act synergic for IL-8 at high toxin concentrations.	zearalenol	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
31357568-5	2019	L-PRPs prepared at 100x g and 100 + 400x g released higher levels of transforming growth factor (TGF)-beta1 and platelet-derived growth factor (PDGF)-BB due to the increased platelet concentration, while inflammatory cytokines interleukin (IL)-8 and tumor necrosis factor (TNF)-alpha were more significantly released from L-PRPs prepared via two centrifugation steps (100 + 400x g and 800 + 400x g) due to the increased concentration of leukocytes.	l-prps	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	227-245
31357693-3	2019	The results showed that 1.0 mM H2O2 pre-exposure for 3 h significantly decreased cell viability, and increased interleukin 8 (IL-8) secretion and the intracellular reactive oxygen species (ROS) level.	Hydrogen Peroxide	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	111-124
31357693-6	2019	Furthermore, the IL-8 secretion and ROS level were significantly blocked by RDE, accompanied by the enhanced gene expression of hemeoxygenase-1 (HO-1), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px), and the enhanced protein expression of the nuclear factor (erythroid-derived 2)-like 2 (Nrf-2).	Glutathione	208-211	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
31357693-3	2019	The results showed that 1.0 mM H2O2 pre-exposure for 3 h significantly decreased cell viability, and increased interleukin 8 (IL-8) secretion and the intracellular reactive oxygen species (ROS) level.	Hydrogen Peroxide	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
31277614-7	2019	The potential for succinic acid to have anti-inflammatory effects was assessed by measuring the release of inflammatory cytokines IL-1alpha, IL-1beta, IL-8 and TNFalpha, and the inflammatory messenger PGE2, from THP-1 human macrophages after treatment with succinic acid and LPS.	Succinic Acid	18-31	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
31324844-5	2019	Production of TNF-alpha, IL-1ss, IL-1RA, MCP-1 and IL-8 was assessed upon addition of 200 microM UA, 500 microM UA or monosodium urate (MSU) crystals in the presence or absence of 5 ng/ml lipopolysaccharide (LPS).	Uric Acid	136-139	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
30978440-0	2019	Cancer-associated fibroblasts-derived IL-8 mediates resistance to cisplatin in human gastric cancer.	Cisplatin	66-75	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
30978440-2	2019	We identified the high pretherapeutical serum IL-8 level in gastric cancer patients was associated with poor response to platinum-based therapy, and it increased gradually during neoadjuvant chemotherapy and it decreased after radical surgery.	Platinum	121-129	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
30978440-5	2019	IL-8 increased the IC50 of cisplatin (CDDP) in AGS or MGC-803 in vitro.	Cisplatin	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
30978440-5	2019	IL-8 increased the IC50 of cisplatin (CDDP) in AGS or MGC-803 in vitro.	cddp	38-42	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
30978440-5	2019	IL-8 increased the IC50 of cisplatin (CDDP) in AGS or MGC-803 in vitro.	mgc-803	54-61	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
31241125-4	2019	(2) Dietary putrescine increased the lysozyme and acid phosphatase activities and the amount of immunoglobulin M, antibacterial peptides, and transforming growth factor beta1, but decreased the mRNA levels of tumor necrosis factor alpha, interleukin-6, interleukin-8 and inducible nitric oxide synthase (P &lt; 0.05).	Putrescine	12-22	C-X-C motif chemokine ligand 8	Homo sapiens	253-266
31354900-0	2019	Corrigendum to "Cafestol Inhibits Cyclic-Strain-Induced Interleukin-8, Intercellular Adhesion Molecule-1, and Monocyte Chemoattractant Protein-1 Production in Vascular Endothelial Cells".	cafestol	16-24	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
31278356-6	2019	Kinetic cell viability testing showed that 500 mug/mL of moxifloxacin exposure induced significant decrease (29%) in the viability as early as 1 h. When the inflammatory effects of the antibiotics were examined, a significant induction of IL-8 was observed especially by RVECs after exposure to cefuroxime or vancomycin which was exacerbated by L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid (Tri-DAP), a NOD1 ligand.	Moxifloxacin	57-69	C-X-C motif chemokine ligand 8	Homo sapiens	239-243
31278356-6	2019	Kinetic cell viability testing showed that 500 mug/mL of moxifloxacin exposure induced significant decrease (29%) in the viability as early as 1 h. When the inflammatory effects of the antibiotics were examined, a significant induction of IL-8 was observed especially by RVECs after exposure to cefuroxime or vancomycin which was exacerbated by L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid (Tri-DAP), a NOD1 ligand.	Cefuroxime	295-305	C-X-C motif chemokine ligand 8	Homo sapiens	239-243
31278356-6	2019	Kinetic cell viability testing showed that 500 mug/mL of moxifloxacin exposure induced significant decrease (29%) in the viability as early as 1 h. When the inflammatory effects of the antibiotics were examined, a significant induction of IL-8 was observed especially by RVECs after exposure to cefuroxime or vancomycin which was exacerbated by L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid (Tri-DAP), a NOD1 ligand.	Vancomycin	309-319	C-X-C motif chemokine ligand 8	Homo sapiens	239-243
31333667-4	2019	PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods.	Poly I-C	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	86-99
31278356-6	2019	Kinetic cell viability testing showed that 500 mug/mL of moxifloxacin exposure induced significant decrease (29%) in the viability as early as 1 h. When the inflammatory effects of the antibiotics were examined, a significant induction of IL-8 was observed especially by RVECs after exposure to cefuroxime or vancomycin which was exacerbated by L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid (Tri-DAP), a NOD1 ligand.	L-Ala-gamma-D-Glu-meso-Dap	345-395	C-X-C motif chemokine ligand 8	Homo sapiens	239-243
31278356-6	2019	Kinetic cell viability testing showed that 500 mug/mL of moxifloxacin exposure induced significant decrease (29%) in the viability as early as 1 h. When the inflammatory effects of the antibiotics were examined, a significant induction of IL-8 was observed especially by RVECs after exposure to cefuroxime or vancomycin which was exacerbated by L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid (Tri-DAP), a NOD1 ligand.	tri-dap	397-404	C-X-C motif chemokine ligand 8	Homo sapiens	239-243
31333667-4	2019	PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods.	Poly I-C	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
31059842-10	2019	Fenofibrate, in presence of IFNgamma plus TNFalpha, dose-dependently inhibited both CXCL10 and CXCL8 release.	Fenofibrate	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	95-100
31005040-5	2019	The results showed that oridonin significantly inhibited inflammatory mediators PGE2, NO, IL-6, and IL-8 production.	oridonin	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
31128992-1	2019	We report a study that seeks to find a correlation between the overall sensitization potential quantified by the expression of IL-8 by stimulated monocytes and the chemical structure of a model contact allergen, 2,4-dinitrochlorobenzene (DNCB).	Dinitrochlorobenzene	212-236	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
31128992-1	2019	We report a study that seeks to find a correlation between the overall sensitization potential quantified by the expression of IL-8 by stimulated monocytes and the chemical structure of a model contact allergen, 2,4-dinitrochlorobenzene (DNCB).	Dinitrochlorobenzene	238-242	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
31293316-2	2019	18F-Sodium fluoride (18F-NaF) is increasingly used in diagnosing skeletal pain which is not identified on radiographs.	18f-sodium fluoride	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
30203224-4	2019	Both dentifrices contained fluoride in the form of NaF/SiO2.	Fluorides	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
30963716-9	2019	Compared to cells treated with oxLDL alone, reactive oxygen species (ROS) generation via nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation and subsequent activation of p38 mitogen-activated protein kinases followed by nuclear factor kappa B (NF-kappaB) activation and related inflammatory responses including adhesion molecule expression, adhesiveness of monocytic cells, and IL-8 release were also aggravated in cells treated with galectin-3 combined with oxLDL.	Reactive Oxygen Species	44-67	C-X-C motif chemokine ligand 8	Homo sapiens	397-401
30963716-9	2019	Compared to cells treated with oxLDL alone, reactive oxygen species (ROS) generation via nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation and subsequent activation of p38 mitogen-activated protein kinases followed by nuclear factor kappa B (NF-kappaB) activation and related inflammatory responses including adhesion molecule expression, adhesiveness of monocytic cells, and IL-8 release were also aggravated in cells treated with galectin-3 combined with oxLDL.	Reactive Oxygen Species	69-72	C-X-C motif chemokine ligand 8	Homo sapiens	397-401
31005040-8	2019	Further studies showed that PPARgamma inhibitor GW9662 could reverse the inhibition of oridonin on PGE2, NO, IL-6, and IL-8 production.	2-chloro-5-nitrobenzanilide	48-54	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
31005040-8	2019	Further studies showed that PPARgamma inhibitor GW9662 could reverse the inhibition of oridonin on PGE2, NO, IL-6, and IL-8 production.	oridonin	87-95	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
30895589-11	2019	Apart from a massive airway inflammation indicated by elevated numbers of total cells and neutrophils, the CBA analysis showed increased levels of IL-6 and IL-8 (p &lt; 0.01).	cba	107-110	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
31326154-9	2019	Among the single plant extracts the Iberis amara extract (IBE) induced high IL-8 releases under non-inflammatory (441 +- 177 pg/ml) and inflammatory (625+- 121 pg/ml) conditions.	ibe	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
31326154-16	2019	CONCLUSION: In Het-1A, STW5 inhibited Il-8 releases, although one of its components (IBE) stimulated IL-8 strongly.	ibe	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
30903189-4	2019	Nd2O3 exposure initiated an inflammatory response in 16HBE cells via the release of the proinflammatory cytokines interleukin (IL)-6 and IL-8.	neodymium oxide	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
30928379-9	2019	Lastly, Treg-secreted high level of IL-8 further induced TGF-beta production from TAMs, and promoted the immunosuppressive tumor microenvironment in MPE.	tams	82-86	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
31243304-6	2019	Moreover, the attenuated ASC response to TNFalpha priming under smicrog was manifested in decreased production of TNFalpha-dependent pleiotropic cytokines (IL-8 and MCP-1), matrix remodeling proteases, and downregulation of some genes encoding growth factors and cytokines.	smicrog	64-71	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
30952010-4	2019	Pretreatment with the DNMT inhibitor 5-Aza-2"-deoxycytidine (5-Aza-CdR) significantly enhanced the expression of the inflammatory cytokines IL-6 and IL-8 in LPS-stimulated hDPCs, indicating that DNA methylation may play a role in hDPC inflammation.	Decitabine	37-59	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
30481303-0	2019	Endothelial cells exposed to phosphate and indoxyl sulphate promote vascular calcification through interleukin-8 secretion.	Phosphates	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	99-112
30481303-0	2019	Endothelial cells exposed to phosphate and indoxyl sulphate promote vascular calcification through interleukin-8 secretion.	Indoxyl sulfate	43-59	C-X-C motif chemokine ligand 8	Homo sapiens	99-112
31084774-1	2019	PET with fluorodeoxyglucose and sodium fluoride (NaF) radiotracers has shown a great promise in assessing patients with multiple myeloma (MM).	Sodium Fluoride	32-47	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
31215467-8	2019	RESULTS: The increase of bioactive fluoride in supernatant saliva was higher after application of NaF or AmF compared to fluoridated bioactive glass.	Fluorides	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	98-101
31242600-5	2019	TNFalpha stimulation led to inducible recruitment of TOP1 to the gene body of IL8, where its inhibition by camptothecin reduced transcription elongation and also led to altered histone H3 acetylation.	Camptothecin	107-119	C-X-C motif chemokine ligand 8	Homo sapiens	78-81
31212975-11	2019	Taken together, these results provide evidence that quercetin protects ARPE-19 cells from the IL-1beta-stimulated increase in ICAM-1, sICAM-1, IL-6, IL-8 and MCP-1 production by blocking the activation of MAPK and NF-kappaB signaling pathways to ameliorate the inflammatory response.	Quercetin	52-61	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
31212975-5	2019	The results showed that quercetin could dose-dependently decrease the mRNA and protein levels of ICAM-1, IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1).	Quercetin	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
31117505-2	2019	All three astaxanthin isomers at 1.2 muM significantly reduced the TNF-alpha-induced secretion of IL-8 by 22-27%.	astaxanthine	10-21	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
31212975-9	2019	U0126 and SB202190 could inhibit the expression of IL-6, IL-8 and MCP-1, but SP600125 could not.	U 0126	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
31212975-9	2019	U0126 and SB202190 could inhibit the expression of IL-6, IL-8 and MCP-1, but SP600125 could not.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	10-18	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
31212975-10	2019	An NF-kappaB inhibitor (Bay 11-7082) also reduced the expression of ICAM-1, sICAM-1, IL-6, IL-8 and MCP-1.	3-(4-methylphenylsulfonyl)-2-propenenitrile	24-35	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
31245395-7	2019	18F-Fluoride (18F-NaF) is an excellent osseous tracer, useful in assessing bone involvement of primary tumors or osseous metastasis.	Fluoride ion f-18	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
30865473-6	2019	Moreover, palmitate induced gene expression (monocyte chemoattractant protein 1, matrix metalloproteinase-2, IL-1beta, IL-6, IL-8, and TNF-alpha) and intracellular protein content (plasminogen activator inhibitor-1 and urokinase plasminogen activator) of inflammatory mediators.	Palmitates	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
31004595-10	2019	Araloside A concentration-dependently curbed the production of interleukin-6, interleukin-8, prostaglandin E2 and nitric oxide in MH7A cells.	araloside A	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	78-91
33911592-7	2019	Results: When skin keratinocytes were pre-treated with SAA, it significantly inhibited poly (I:C)-induced expression of inflammatory cytokines including interleukin (IL)-1beta, IL-6, IL-8, tumor necrosis factor-alpha, and CCL20.	Poly I-C	87-97	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
31010851-5	2019	Despite possessing an intact N terminus and preserved disulfide bonds, SpyCEP-cleaved CXCL8 had impaired binding to both CXCR1 and CXCR2, pointing to a requirement for the C-terminal alpha-helix.	Disulfides	54-63	C-X-C motif chemokine ligand 8	Homo sapiens	86-91
30466341-4	2019	Results: LPS-induced expressions of pro-inflammatory genes IL-6, IL-8, TNF-alpha, IL-1beta, MCP-1, MMP-9, iNOS and COX-2 were significantly and dose-dependently suppressed by XAV939.	XAV939	175-181	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
30415310-0	2019	The phosphodiesterase 5 inhibitor sildenafil decreases the proinflammatory chemokine IL-8 in diabetic cardiomyopathy: in vivo and in vitro evidence.	Sildenafil Citrate	34-44	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
30415310-4	2019	METHODS: IL-8 was quantified: in sera of (30) DCM subjects before (baseline) and after sildenafil (100 mg/day, 3-months) vs. (16) placebo and (15) healthy subjects, by multiplatform array; in supernatants from inflammation-challenged cells after sildenafil (1 microM), by ELISA.	Sildenafil Citrate	87-97	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
30415310-6	2019	Sildenafil, not placebo, significantly reduced serum IL-8 (23.7 +- 5.9 pg/ml, p &lt; 0.05 vs. baseline).	Sildenafil Citrate	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
30415310-8	2019	Sildenafil significantly decreased IL-8 protein release by inflammation-induced Hfaec and PBMC and downregulated IL-8 mRNA in PBMC, without affecting cell number or PDE5 expression.	Sildenafil Citrate	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
30415310-8	2019	Sildenafil significantly decreased IL-8 protein release by inflammation-induced Hfaec and PBMC and downregulated IL-8 mRNA in PBMC, without affecting cell number or PDE5 expression.	Sildenafil Citrate	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
30415310-9	2019	CONCLUSION: Sildenafil might be suggested as potential novel pharmacological tool to control DCM progression through IL-8 targeting at systemic and cellular level.	Sildenafil Citrate	12-22	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
30478740-9	2019	Remarkable, after 6 h CdCl2-treatment, a relevant increase in TNF-alpha, IL-6 and IL-8 mRNA was observed and this effect was blocked by the presence of an ERbeta-selective antagonist.	Cadmium Chloride	22-27	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
31101589-6	2019	Rifamycin also antagonized TNFalpha and LPS-induced NFkappaB activities and inhibited IL1beta-induced synthesis of inflammatory chemokine, IL8.	rifamycin SV	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	139-142
31101589-8	2019	Thus, rifamycin exhibits potent anti-inflammatory activities, characterized by in vitro PXR activation and concomitant CYP3A4 and PgP induction, in parallel with potent NFkappaB inhibition and concomitant IL8 inhibition.	rifamycin SV	6-15	C-X-C motif chemokine ligand 8	Homo sapiens	205-208
30888047-6	2019	In human cells, while Cr induced a release of ATP, IL-6, and IL-8 from BEAS-2B cells, whole blood cells, such as eosinophils, and CD4+ T cells, P2 x 7 receptor inhibitor (A740003) reduced such effects, as denoted by reduced levels of ATP, IL-6, and IL-8.	Creatine	22-24	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
30888047-6	2019	In human cells, while Cr induced a release of ATP, IL-6, and IL-8 from BEAS-2B cells, whole blood cells, such as eosinophils, and CD4+ T cells, P2 x 7 receptor inhibitor (A740003) reduced such effects, as denoted by reduced levels of ATP, IL-6, and IL-8.	Creatine	22-24	C-X-C motif chemokine ligand 8	Homo sapiens	249-253
31183190-3	2019	Levocetirizine is a second generation H1 antihistamine with anti-inflammatory and IL-8 suppression properties.	levocetirizine	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
31010851-6	2019	SpyCEP-cleaved CXCL8 had similarly impaired binding to the glycosaminoglycan heparin.	glycosaminoglycan heparin	59-84	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
31010851-7	2019	Enzymatic removal of neutrophil glycosaminoglycans was observed to ablate neutrophil navigation of a CXCL8 gradient, whereas navigation of an fMLF gradient remained largely intact.	Glycosaminoglycans	32-50	C-X-C motif chemokine ligand 8	Homo sapiens	101-106
31002348-0	2019	Acquisition of gemcitabine resistance enhances angiogenesis via upregulation of IL-8 production in pancreatic cancer.	gemcitabine	15-26	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
30688757-1	2019	BACKGROUND: Fluorine-18-labeled sodium fluoride (F-NaF) uptake measured with PET in the vessel walls can indicate active microcalcification, a potential biomarker of higher-risk plaques, which are not indicated by macrocalcification measured with computed tomography (CT).	Fluorine-18	12-23	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
30688757-1	2019	BACKGROUND: Fluorine-18-labeled sodium fluoride (F-NaF) uptake measured with PET in the vessel walls can indicate active microcalcification, a potential biomarker of higher-risk plaques, which are not indicated by macrocalcification measured with computed tomography (CT).	Sodium Fluoride	32-47	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
30688757-2	2019	The aim of this study was to determine the extent to which F-NaF uptake is correlated with calcification at arterial plaques in cancer patients undergoing whole-body PET/CT imaging.	Fluorine	59-60	C-X-C motif chemokine ligand 8	Homo sapiens	61-64
30688757-7	2019	We found a weak but statistically significant positive correlation between CS and F-NaF uptake.	Cesium	75-77	C-X-C motif chemokine ligand 8	Homo sapiens	84-87
31028903-5	2019	Exposure of these cells to lipogenic (insulin, glucose, fatty acids) and pro-inflammatory factors (IL-1beta, TNF-alpha, TGF-beta) resulted in a characteristic NASH response, as indicated by intracellular lipid accumulation, modulation of NASH-specific gene expression, increased caspase-3/7 activity and the expression and/or secretion of inflammatory markers, including CCL2, CCL5, CCL7, CCL8, CXCL5, CXCL8, IL1a, IL6 and IL11.	Fatty Acids	56-67	C-X-C motif chemokine ligand 8	Homo sapiens	402-407
31245005-9	2019	For example, women who had elevated DGLA (highest quartile) were twice as (adjusted OR 2.06, 95% CI 1.42 to 2.98) likely to have higher interleukin (IL)-8 (p<0.0001) levels.	8,11,14-Eicosatrienoic Acid	36-40	C-X-C motif chemokine ligand 8	Homo sapiens	136-154
31292053-4	2019	Reverse transcription PCR was used to test the effect of U0126 at different concentrations (0, 1, 5, 10 mumol/L) on the mRNA expression of IL-8 induced by Stattic in THP-1 cells.	U 0126	57-62	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
31292053-9	2019	In addition, U0126, a selective inhibitor of ERK pathway, inhibited Stattic-induced IL-8 expression in a concentration-dependent manner.	U 0126	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
31070650-6	2019	Furthermore, TPA obviously assuaged TNF-alpha-evoked up-regulation of IL-8 and IL-6 expression, down-regulation of occludin and ZO-3 expression, and markedly suppressed the activation and protein expression of NF-kappaB p65.	Tetradecanoylphorbol Acetate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
31231362-9	2019	C-SVMP was able to induce increased production of the cytokines IL-1beta and IL-6 and the chemokines CXCL8/IL-8, CCL2/MCP-1, and CXCL9/MIG in the human whole blood model.	c-svmp	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	101-106
31231362-9	2019	C-SVMP was able to induce increased production of the cytokines IL-1beta and IL-6 and the chemokines CXCL8/IL-8, CCL2/MCP-1, and CXCL9/MIG in the human whole blood model.	c-svmp	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
31231362-10	2019	The addition of compstatin to the reactions caused a significant reduction in the production of IL-1beta, CXCL8/IL-8, and CCL2/MCP-1 in cells treated with C-SVMP.	c-svmp	155-161	C-X-C motif chemokine ligand 8	Homo sapiens	106-111
31113462-9	2019	CuO NMs and CuSO4 stimulated an increase in IL-8 secretion, which was greatest in the Caco-2/HT29-MTX co-culture model.	cupric oxide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
31113462-9	2019	CuO NMs and CuSO4 stimulated an increase in IL-8 secretion, which was greatest in the Caco-2/HT29-MTX co-culture model.	Copper Sulfate	12-17	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
31113462-9	2019	CuO NMs and CuSO4 stimulated an increase in IL-8 secretion, which was greatest in the Caco-2/HT29-MTX co-culture model.	Methotrexate	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
30851105-4	2019	First, we demonstrated that levels of Cinc-1, the rat homolog of IL-8, are increased in the lung fluid and tissue compartment in a rat model of DA-induced BO.	amsonic acid	144-146	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
30851105-6	2019	We then tested the hypothesis that DA-induced epithelial IL-8 protein occurs in an epidermal growth factor receptor (EGFR)-dependent manner.	amsonic acid	35-37	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
30851105-7	2019	In these in vitro experiments we demonstrated that epithelial IL-8 protein is blocked by the EGFR tyrosine kinase inhibitor AG1478 and by inhibition of tumor necrosis factor-alpha converting enzyme using the small molecule inhibitor, TAPI-1.	RTKI cpd	124-130	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
30851105-8	2019	Finally, we demonstrated that DA-induced IL-8 is dependent upon ERK1/2 and Mitogen activated protein kinase kinase activation downstream of EGFR signaling using the small molecule inhibitors AG1478 and PD98059.	amsonic acid	30-32	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
30851105-8	2019	Finally, we demonstrated that DA-induced IL-8 is dependent upon ERK1/2 and Mitogen activated protein kinase kinase activation downstream of EGFR signaling using the small molecule inhibitors AG1478 and PD98059.	RTKI cpd	191-197	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
30851105-8	2019	Finally, we demonstrated that DA-induced IL-8 is dependent upon ERK1/2 and Mitogen activated protein kinase kinase activation downstream of EGFR signaling using the small molecule inhibitors AG1478 and PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	202-209	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
31130634-5	2019	The results showed that Phlor (10-50 muM) decreased the synthesis of PGE2 and IL-8 and the formation of AGEs by different mechanisms.	Phloretin	24-29	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
31245005-10	2019	Conversely, women with high palmitoleic, oleic, and linolenic acid levels had reduced odds (>=2-fold, p<0.01 to p<0.001) for having higher IL-8, IL-6 or tumor necrosis factor-alpha levels.	oleic	34-39	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
31245005-10	2019	Conversely, women with high palmitoleic, oleic, and linolenic acid levels had reduced odds (>=2-fold, p<0.01 to p<0.001) for having higher IL-8, IL-6 or tumor necrosis factor-alpha levels.	alpha-Linolenic Acid	52-66	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
31139184-3	2019	Pretreatment of human RASFs with JWH-015 (10-20 muM) markedly inhibited the ability of pro-inflammatory cytokine interleukin-1beta (IL-1beta) to induce production of IL-6 and IL-8 and cellular expression of inflammatory cyclooxygenase-2 (COX-2).	JHW 015	33-40	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
30996116-6	2019	DOX influenced inflammatory responses by inducing a significant increase in the expression of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and cyclooxigenase-2 (COX-2), of inflammatory interleukins (IL), such as interleukin-6 (IL-6) and interleukin-8 (IL-8), and the inflammatory proteins mediators metalloproteinase-2 and metalloproteinase-9 (MMP2 and MMP9).	Doxorubicin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	268-281
30996116-6	2019	DOX influenced inflammatory responses by inducing a significant increase in the expression of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and cyclooxigenase-2 (COX-2), of inflammatory interleukins (IL), such as interleukin-6 (IL-6) and interleukin-8 (IL-8), and the inflammatory proteins mediators metalloproteinase-2 and metalloproteinase-9 (MMP2 and MMP9).	Doxorubicin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	283-287
30996116-7	2019	IL-8 secretion in the culture supernatants and MMP9 activity also significantly raised after DOX treatment.	Doxorubicin	93-96	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
31105936-2	2019	Uptake of 18F-sodium fluoride (18F-NaF) in the aortic wall reflects metabolically active areas of calcification.	18f-sodium fluoride	10-29	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
31053727-7	2019	Furthermore, transfected chondrocytes with miR-125b mimic in the presence of IL-1beta also showed marked inhibition in the secretion of several proinflammatory cytokines, chemokines and growth factors including IL-6, IL-8, INF-gamma, TGF-beta1, IGFBP-1 and PGDF-BB.	mir-125b	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
31105936-11	2019	Conclusion: In a cohort of postmenopausal women, 18F-NaF uptake as measured by TBR in the lumbar aorta did not predict progression of aortic calcification as detected by computed tomography over a four-year follow-up.	tbr	79-82	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
29232287-7	2019	Similar effects on IL-1beta, IL-6, and IL-8 levels were observed when cells were treated with simvastatin, pravastatin, and the renin-angiotensin system inhibitors spironolactone, captopril, lisinopril, candesartan, and losartan.	Simvastatin	94-105	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
31052583-8	2019	NM-200 induced production of IL-8, a potent attractor and activator of neutrophils, growth factors (VEGF and IGF-1) and superoxide.	nm-200	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
31052583-8	2019	NM-200 induced production of IL-8, a potent attractor and activator of neutrophils, growth factors (VEGF and IGF-1) and superoxide.	Superoxides	120-130	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
29232287-7	2019	Similar effects on IL-1beta, IL-6, and IL-8 levels were observed when cells were treated with simvastatin, pravastatin, and the renin-angiotensin system inhibitors spironolactone, captopril, lisinopril, candesartan, and losartan.	Pravastatin	107-118	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
30648905-5	2019	In both cell types, challenge with arachidonic acid (AA) (omega-6 PUFA) and poly(I:C) or LTA led to substantially greater IL-6 and CXCL8 release than either challenge alone, demonstrating synergy.	Arachidonic Acid	35-51	C-X-C motif chemokine ligand 8	Homo sapiens	131-136
30726114-5	2019	Meanwhile, fMLF or IL-8 stimulation yields the longer terminating time than that on PMA stimulation but results in a similar shedding extent for PMNs.	Tetradecanoylphorbol Acetate	84-87	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
30648905-5	2019	In both cell types, challenge with arachidonic acid (AA) (omega-6 PUFA) and poly(I:C) or LTA led to substantially greater IL-6 and CXCL8 release than either challenge alone, demonstrating synergy.	omega-6 pufa	58-70	C-X-C motif chemokine ligand 8	Homo sapiens	131-136
30851246-3	2019	When tested in vitro on human dendritic cells (DCs), CHF6001 decreased the release of pro-inflammatory cytokines (TNF-alpha and IL-6), chemokines (CXCL8, CCL3, CXCL10 and CCL19) and of Th1- and Th17-polarizing cytokines (IL-12, IL-23 and IL-1beta).	3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide	53-60	C-X-C motif chemokine ligand 8	Homo sapiens	147-152
30846359-0	2019	Decitabine improves platelet recovery by down-regulating IL-8 level in MDS/AML patients with thrombocytopenia.	Decitabine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
30922967-5	2019	However, the intracellular superoxide, Zn ions, or release of interleukin-8 after ZnO NP exposure were not significantly affected by the presence of CC.	zno np	82-88	C-X-C motif chemokine ligand 8	Homo sapiens	62-75
30888996-1	2019	PURPOSE: [F]-sodium fluoride ([F]NaF) is a well-established bone-seeking agent that has shown promise to assess bone turnover in a variety of disorders, but its distribution in healthy knee joints has not been explored.	Sodium Fluoride	13-28	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
30884698-7	2019	Storage of TiO2 nanoparticles inside the cells affected enterocytes viability and triggered the production of pro-inflammatory cytokines, including TNF-alpha and IL-8.	titanium dioxide	11-15	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
30306335-11	2019	However, only NaF-gel2 and NaF-TP induced remineralization.	neotetrazolium	31-33	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
30867226-0	2019	Role of Protein Tyrosine Phosphatase Epsilon (PTPepsilon) in Leukotriene D4-Induced CXCL8 Expression.	Leukotriene D4	61-75	C-X-C motif chemokine ligand 8	Homo sapiens	84-89
31934009-5	2019	Pearson correlation analysis showed that the serum 25(OH)D level in patients with T2DM had a negative correlation with HOMA-IR (r=-0.750, P&lt;0.001), TNF-alpha (r=-0.705, P&lt;0.001), IL-1beta (r=-0.661, P&lt;0.001), IL-8 (r=-0.645, P&lt;0.001), and IL-6 (r=-0.609, P&lt;0.001).	25-hydroxyvitamin D3-bromoacetate	51-58	C-X-C motif chemokine ligand 8	Homo sapiens	218-222
31005721-8	2019	EGCG treatment reduced CSM-induced inflammatory chemokine interleukin (IL)-8 productions in the supernatant via the inhibition of ERK1/2, p38 MAPK and NF-kappaB pathways.	epigallocatechin gallate	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	58-76
30535530-5	2019	More importantly, treatment of HepG2 cells with rAGAP downregulated protein expression of HIF-1alpha, suppressed activities of HIF, reduced secretion of VEGF and IL-8, and suppressed HepG2-induced tube formation by HUVEC, which was reversed by co-incubation with SC-79 (an AKT activator).	ragap	48-53	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
30426301-6	2019	Treatment of the senescent hHSCs with ERK1/2 inhibitor, SCH772984, significantly decreased the levels of angiopoietin like 4 (ANGPTL4), C-C motif chemokine ligand 7 (CCL7), Interleukin-8 (IL-8), platelet factor 4 variant 1 (PF4V1), and TNF superfamily member 15 (TNFSF15) mRNA levels in a dose-dependent manner.	SCH772984	56-65	C-X-C motif chemokine ligand 8	Homo sapiens	173-186
30426301-6	2019	Treatment of the senescent hHSCs with ERK1/2 inhibitor, SCH772984, significantly decreased the levels of angiopoietin like 4 (ANGPTL4), C-C motif chemokine ligand 7 (CCL7), Interleukin-8 (IL-8), platelet factor 4 variant 1 (PF4V1), and TNF superfamily member 15 (TNFSF15) mRNA levels in a dose-dependent manner.	SCH772984	56-65	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
30461332-6	2019	Moreover, only co-exposure to ZnO NPs and SA significantly promoted the release of interleukin-8.	Zinc Oxide	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	83-96
30248704-0	2019	Serine Protease Mauritanicain from Euphorbia mauritanica and Phorbol-12-myristate-13-acetate Modulate the IL-8 Release in Fibroblasts and HaCaT Keratinocytes.	Tetradecanoylphorbol Acetate	61-92	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
30248704-7	2019	The results indicated that the combination of the protease mauritanicain from Euphorbia mauritanica and phorbol-12-myristate-13-acetate induced a significantly increased IL-8 release in HaCaT keratinocytes compared to single treatments.	Tetradecanoylphorbol Acetate	104-135	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
30461332-6	2019	Moreover, only co-exposure to ZnO NPs and SA significantly promoted the release of interleukin-8.	stearic acid	42-44	C-X-C motif chemokine ligand 8	Homo sapiens	83-96
31110480-8	2019	Results: In the present study, RIPC treatment significantly reduced plasma levels of cardiac troponin T (p &lt; 0.05), heart-type fatty acid binding protein (p &lt; 0.05), ischemia modified albumin (p &lt; 0.05), malondialdehyde (p &lt; 0.05), as well as plasma levels of pro-inflammatory cytokines including IL-6, IL-8, and TNF-alpha (P &lt; 0.05, respectively).	ripc	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	315-319
31101174-14	2019	The rejection group maintained higher levels of IL-8 for 11 days (range: 7-30) compared to the SGF group (P = .002) and the IL-8 levels correlated with serum creatinine levels (r = 0.621, P = .001).	Creatinine	158-168	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
31044584-4	2019	Furthermore, by potentially up-regulating A2A and A3 adenosine receptors, EMF increases cAMP accumulation from astrocytes and reduces the expression of inflammatory cytokines TNF alpha and IL-8, thus initiating neurorestoration.	Adenosine	53-62	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
30753461-5	2019	We further showed that treatment with FK506 (tacrolimus) possibly inhibits the increase in IL-8 levels in RA patients with anti-RANKL Ab, and in vitro assay confirmed that FK506 suppressed IL-8 production in pre-OCLs.	Tacrolimus	38-43	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
30753461-5	2019	We further showed that treatment with FK506 (tacrolimus) possibly inhibits the increase in IL-8 levels in RA patients with anti-RANKL Ab, and in vitro assay confirmed that FK506 suppressed IL-8 production in pre-OCLs.	Tacrolimus	38-43	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
30753461-5	2019	We further showed that treatment with FK506 (tacrolimus) possibly inhibits the increase in IL-8 levels in RA patients with anti-RANKL Ab, and in vitro assay confirmed that FK506 suppressed IL-8 production in pre-OCLs.	Tacrolimus	45-55	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
30753461-5	2019	We further showed that treatment with FK506 (tacrolimus) possibly inhibits the increase in IL-8 levels in RA patients with anti-RANKL Ab, and in vitro assay confirmed that FK506 suppressed IL-8 production in pre-OCLs.	Tacrolimus	45-55	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
30753461-5	2019	We further showed that treatment with FK506 (tacrolimus) possibly inhibits the increase in IL-8 levels in RA patients with anti-RANKL Ab, and in vitro assay confirmed that FK506 suppressed IL-8 production in pre-OCLs.	Tacrolimus	172-177	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
30753461-5	2019	We further showed that treatment with FK506 (tacrolimus) possibly inhibits the increase in IL-8 levels in RA patients with anti-RANKL Ab, and in vitro assay confirmed that FK506 suppressed IL-8 production in pre-OCLs.	Tacrolimus	172-177	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
31008484-6	2019	EP1/EP3 agonist 17-phenyl-trinor-PGE2 stimulated IL-6 and TNFalpha whilst suppressing IL-1beta and CXCL8 output.	17-phenyltrinorprostaglandin E2	16-37	C-X-C motif chemokine ligand 8	Homo sapiens	99-104
31008484-5	2019	The results showed that, PGE2 increased interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFalpha) output, decreased chemokine (c-x-c motif) ligand 8 (CXCL8) output in a dose-dependent manner, but had no effect on IL-1beta and chemokine (c-c motif) ligand 2 (CCL-2) secretion of HUSMCs.	Dinoprostone	25-29	C-X-C motif chemokine ligand 8	Homo sapiens	156-161
31008484-7	2019	The effects of 17-phenyl-trinor-PGE2 on IL-1beta and CXCL8 secretion were remained whereas its effect on IL-6 and TNFalpha output did not occur in the cells with EP3 knockdown.	17-phenyltrinorprostaglandin E2	15-36	C-X-C motif chemokine ligand 8	Homo sapiens	53-58
31017900-9	2019	ML2044-stimulated IL-4 and CXCL8/IL-8 achieved the highest sensitivity (85.71% and 100%) and the highest specificity (95.24% and 84.21%) for discriminating PB patients from HHCs and TB patients, respectively.	pladienolide B	156-158	C-X-C motif chemokine ligand 8	Homo sapiens	27-32
31105691-5	2019	DAPT also inhibited the contact-dependent induction of CXCL8, but not of CCL5, in TNFalpha- and IL-1beta-stimulated TNBC:MSC/CAF co-cultures; some level of heterogeneity between the responses of different TNBC cell lines was noted, with MDA-MB-231:MSC/CAF co-cultures being the most sensitive to DAPT.	dapt	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	55-60
31017900-9	2019	ML2044-stimulated IL-4 and CXCL8/IL-8 achieved the highest sensitivity (85.71% and 100%) and the highest specificity (95.24% and 84.21%) for discriminating PB patients from HHCs and TB patients, respectively.	pladienolide B	156-158	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
31105821-6	2019	Notably, our findings indicate that sitagliptin possesses an anti-inflammatory effect against H/R-induced expression of IL-6, IL-8, and TNF-alpha as well as secretion of HMGB1.	Sitagliptin Phosphate	36-47	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
30084946-0	2019	Chronic Resveratrol Treatment Reduces the Pro-angiogenic Effect of Human Fibroblast "Senescent-Associated Secretory Phenotype" on Endothelial Colony-Forming Cells: The Role of IL8.	Resveratrol	8-19	C-X-C motif chemokine ligand 8	Homo sapiens	176-179
30084946-6	2019	IL8-subtraction mitigated the pro-angiogenic features of CM sen and the associated intracellular signaling in ECFCs, indicating a prominent role of IL8 in the pro-angiogenic effects of CM sen.	cm sen	57-63	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
30084946-6	2019	IL8-subtraction mitigated the pro-angiogenic features of CM sen and the associated intracellular signaling in ECFCs, indicating a prominent role of IL8 in the pro-angiogenic effects of CM sen.	cm sen	185-191	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
30084946-6	2019	IL8-subtraction mitigated the pro-angiogenic features of CM sen and the associated intracellular signaling in ECFCs, indicating a prominent role of IL8 in the pro-angiogenic effects of CM sen.	cm sen	185-191	C-X-C motif chemokine ligand 8	Homo sapiens	148-151
30084946-7	2019	IL8 modulation is an important mechanism underlying the antiangiogenic activity of resveratrol on MRC5 SASP.	Resveratrol	83-94	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
30797108-1	2019	In the present work, for the first time we takes the advantages of chitosan-Nafion (Chit-Naf) composite as a highly conductive surface platform and a novel CNT-based signal amplification strategy to develop a lable-free impedimetricaptamer-based sensor for highly sensitive detection of As(III).	as(iii)	287-294	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
30797108-2	2019	The electrochemical impedance spectroscopy (EIS) investigations surprisingly revealed that the glassy carbon electrode (GC) electrode modified with Chit-Naf composite had higher electron transfer kinetics compared the bare GC, GC/Naf and GC/Chit electrodes, which promises a great potential as an efficient platform in construction of biosensing assays.	Carbon	102-108	C-X-C motif chemokine ligand 8	Homo sapiens	153-156
30797108-2	2019	The electrochemical impedance spectroscopy (EIS) investigations surprisingly revealed that the glassy carbon electrode (GC) electrode modified with Chit-Naf composite had higher electron transfer kinetics compared the bare GC, GC/Naf and GC/Chit electrodes, which promises a great potential as an efficient platform in construction of biosensing assays.	Carbon	102-108	C-X-C motif chemokine ligand 8	Homo sapiens	230-233
31010106-11	2019	The levels of IL-8, C reactive protein (CRP), and cyclooxygenase (COX)-2 increased only after exposure to I-PM2.5.	i-pm2	106-111	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
31015845-11	2019	Conclusion: We speculate that in young children with sleep-related CIH, an enhanced production capacity of IL-8 precedes the development of systemic inflammatory markers.	cih	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
31105821-6	2019	Notably, our findings indicate that sitagliptin possesses an anti-inflammatory effect against H/R-induced expression of IL-6, IL-8, and TNF-alpha as well as secretion of HMGB1.	r	96-97	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
30969964-6	2019	Mutations of the CXCL8-UTR-reporter revealed that cell type-specific expression required: 1) a 3" UTR of at least three hundred bases; and 2) an AU base content that exceeds fifty percent in the first hundred bases of the 3" UTR immediately after the stop codon, which we dub AU-rich proximal UTR sequences (APS).	Gold	145-147	C-X-C motif chemokine ligand 8	Homo sapiens	17-22
30796179-9	2019	Q0bolton-AAT bound IL-8 and leukotriene B4, comparable to healthy control M-AAT, and significantly decreased leukotriene B4-induced neutrophil adhesion (p = 0.04).	q0bolton-aat	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
30664962-10	2019	Pyrazinib (P3) significantly reduced the secretions of IL-6 (p = 0.0006), IL-8 (p = 0.0488), and IL-4 (p = 0.0111) in OE33R cells.	SCHEMBL9791651	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
30836753-5	2019	Moreover, the adsorption property with respect to Cd2+ and Ni2+ in wastewater has been largely effected by the pH and was less influenced by the ionic strength and humic acid, and the GCP1:2:4 hydrogel possessed excellent adsorptive and recyclable properties.	Nickel(2+)	59-63	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
30972350-6	2019	The effect of LPNs on lipopolysaccharide (LPS)-induced IL-8 production from human NuLi-1 BECs was tested by ELISA.	lpns	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
30972350-10	2019	Nebulised miR-17-loaded LPNs downregulated LPS-induced IL-8 secretion by &gt;40% in BECs.	lpns	24-28	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
30860845-0	2019	Quantum Dynamics Calculations of Na (32S, 32P) + HF   NaF + H Reactions.	32S	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
30860845-0	2019	Quantum Dynamics Calculations of Na (32S, 32P) + HF   NaF + H Reactions.	Phosphorus-32	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
30860845-6	2019	For the Na(3P) + HF scattering, which can lead to the formation of either the ground state NaF + H product or Na(3S) + HF reactant via the harpooning process, the calculated result for the integral cross section shows excellent agreement with the available experimental result indicating the reasonable accuracy of the interstate coupling term of the employed PES.	na(3p)	8-14	C-X-C motif chemokine ligand 8	Homo sapiens	91-94
30860845-6	2019	For the Na(3P) + HF scattering, which can lead to the formation of either the ground state NaF + H product or Na(3S) + HF reactant via the harpooning process, the calculated result for the integral cross section shows excellent agreement with the available experimental result indicating the reasonable accuracy of the interstate coupling term of the employed PES.	na(3s)	110-116	C-X-C motif chemokine ligand 8	Homo sapiens	91-94
30864448-0	2019	Structural Origins of RF3/NaRF4 Nanocrystal Precipitation from Phase-Separated SiO2-Al2O3-RF3-NaF Glasses: A Molecular Dynamics Simulation Study.	1-(thiophen-2-ylacetyl)-4-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)piperidine	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	94-97
31041358-10	2019	Interleukin-8 levels increased in nasal samples (using synthetic absorptive matrix strips) and decreased serum neutrophil-elastase-mediated degradation of elastin decreased in danirixin-treated participants, suggesting effective target engagement.	danirixin	176-185	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
30864448-0	2019	Structural Origins of RF3/NaRF4 Nanocrystal Precipitation from Phase-Separated SiO2-Al2O3-RF3-NaF Glasses: A Molecular Dynamics Simulation Study.	narf4	26-31	C-X-C motif chemokine ligand 8	Homo sapiens	94-97
30864448-4	2019	These fluoride-enriched regions can serve as the precursor for RF3, cubic and hexagonal NaRF4, and NaF crystal precipitation.	Fluorides	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
30864448-5	2019	The results also confirm that the concentration of Na+ in the fluoride phase plays a key role in determining the crystal phases (RF3, NaRF4, or NaF) and crystal structure (cubic vs hexagonal NaRF4) to be precipitated.	Fluorides	62-70	C-X-C motif chemokine ligand 8	Homo sapiens	144-147
30836753-6	2019	These results demonstrated that the GCP1:2:4 hydrogel could serve as a desirable adsorbent to get rid of heavy metal ions in sewage.	Metals	111-116	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
30846336-1	2019	BACKGROUND: Fluorine-18 sodium fluoride (NaF), a bone-seeking radiopharmaceutical used to detect osseous metastases, localizes in regions of microcalcification in atherosclerosis.	fluorine-18 sodium fluoride	12-39	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
29931577-4	2019	The results showed that sodium fluoride (NaF) induced deacetylation and decreased expression of the p16 gene via inhibition of specificity protein 1 (Sp1) binding to its response element, which accounts for NaF increasing cell viability and promoting proliferation in human primary osteoblasts.	Sodium Fluoride	24-39	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
30652495-12	2019	The antioxidant N-acetylcysteine prevents CSE-induced miR-29b downregulation and BRD4 and IL-8 upregulation.	Acetylcysteine	16-32	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
29931577-4	2019	The results showed that sodium fluoride (NaF) induced deacetylation and decreased expression of the p16 gene via inhibition of specificity protein 1 (Sp1) binding to its response element, which accounts for NaF increasing cell viability and promoting proliferation in human primary osteoblasts.	Sodium Fluoride	24-39	C-X-C motif chemokine ligand 8	Homo sapiens	207-210
30660785-7	2019	RESULTS: Bacterial biomass, neutrophil percentage, IL-8, and IL-1beta levels were significantly higher in children with PBB compared with control patients.	pbb	120-123	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
31025289-10	2019	A significant increase in CXCL8 and FGF-2 expression was observed with HPAF-CD11/CAFs co-culture and to a lower extent with HPAF/CAFs co-culture.	hpaf-cd11	71-80	C-X-C motif chemokine ligand 8	Homo sapiens	26-31
31025289-10	2019	A significant increase in CXCL8 and FGF-2 expression was observed with HPAF-CD11/CAFs co-culture and to a lower extent with HPAF/CAFs co-culture.	hpaf	71-75	C-X-C motif chemokine ligand 8	Homo sapiens	26-31
30548842-5	2019	The affinity of the resulting tetramethylrhodamine-labeled macrocyclic peptomers to CXCL8 is increased by at least 1 order of magnitude compared to the original linear sequences.	tetramethylrhodamine	30-50	C-X-C motif chemokine ligand 8	Homo sapiens	84-89
30585832-9	2019	In contrast, acetylsalicylic acid treatment resulted in enhanced plasma levels of tumor necrosis factor-alpha (+53%; p = 0.02), interleukin-6 (+91%; p = 0.03), and interleukin-8 (+42%; p = 0.02) upon the second challenge, whereas plasma levels of the key antiinflammatory cytokine interleukin-10 were attenuated (-40%; p = 0.003).	Aspirin	13-33	C-X-C motif chemokine ligand 8	Homo sapiens	164-177
30906451-10	2019	Puerarin preconditioning can reduce the NF-kappaB activation and the overexpression of IL-6 and IL-8 in neutrophils, and it inhibits the release of myocardial enzyme cTnI and CK-MB reflecting myocardial cell protection.	puerarin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
30823334-11	2019	Interleukin 8 was inversely associated with PFOS and PFNA.	perfluorooctane sulfonic acid	44-48	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
30341641-5	2019	Hybrid imaging with bone-seeking tracers such as SPECT/CT with 99mTc-labelled bisphosphonates or PET/CT with 18F-labelled sodium fluoride (18F-NaF) combines high radionuclide uptake with morphological details and provides accurate diagnosis of osteoid osteoma and additional information for treatment planning.	Sodium Fluoride	122-137	C-X-C motif chemokine ligand 8	Homo sapiens	143-146
30935522-6	2019	DISCUSSION: GTP play a role in reducing TNF-alpha, Interleukin 1beta (IL-1beta), IL-6, IL-8, and 17; downregulate cyclooxygenase-mediated I kappa B kinase and transcription of NFkappaB.	Guanosine Triphosphate	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
30623574-2	2019	Proinflammatory cytokines IL-6 and IL-8 are related to steroid-insensitive asthma.	Steroids	55-62	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
30623574-7	2019	Both Erlotinib (Tarceva) and Osimertinib (AZD-9291) reduced the levels of HDM-stimulated IL-6 and IL-8 levels in BEAS-2B cells.	Erlotinib Hydrochloride	5-14	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
30623574-7	2019	Both Erlotinib (Tarceva) and Osimertinib (AZD-9291) reduced the levels of HDM-stimulated IL-6 and IL-8 levels in BEAS-2B cells.	Erlotinib Hydrochloride	16-23	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
30623574-7	2019	Both Erlotinib (Tarceva) and Osimertinib (AZD-9291) reduced the levels of HDM-stimulated IL-6 and IL-8 levels in BEAS-2B cells.	osimertinib	29-40	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
30623574-7	2019	Both Erlotinib (Tarceva) and Osimertinib (AZD-9291) reduced the levels of HDM-stimulated IL-6 and IL-8 levels in BEAS-2B cells.	osimertinib	42-50	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
30623574-10	2019	Our findings highlight EGFR-TKIs, Tarceva, and AZD-9291, attenuate HDM-induced inflammatory IL-6 and IL-8 cytokines via EGFR signaling axis pathway, but not AMPK signaling pathway.	Erlotinib Hydrochloride	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
30623574-10	2019	Our findings highlight EGFR-TKIs, Tarceva, and AZD-9291, attenuate HDM-induced inflammatory IL-6 and IL-8 cytokines via EGFR signaling axis pathway, but not AMPK signaling pathway.	osimertinib	47-55	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
30906451-7	2019	The positive rates of NF-kappaB, IL-6 and IL-8 at different time-points were lower in patients of the puerarin group than in those of the control group (and the differences at T3 were statistically significant).	puerarin	102-110	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
30739130-7	2019	Biomarker profiling indicated potential modest effects of toreforant on gene expression of histamine-1-receptor, tumor necrosis factor-alpha, and interleukin-8 in synovium.	Toreforant	58-68	C-X-C motif chemokine ligand 8	Homo sapiens	146-159
30592634-5	2019	To elucidate the function of paracrine CXCL8 in AML, we blocked CXCL8 binding to the C-X-C motif chemokine receptor (CXCR)2 in the AML cells using SB225002.	SB 225002	147-155	C-X-C motif chemokine ligand 8	Homo sapiens	64-69
30295316-16	2019	Vitamin D inhibited IL-6 and IL-8 production stimulated by G-HSA or HSA + IL-1beta or IL-1beta + IL-17.	g-hsa	59-64	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
29524030-5	2019	The vitreous IL-8 level of DME patients with subretinal fluid was significantly higher than both control (p = 0.002) and DME without subretinal fluid groups (p = 0.019).	dme	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
29524030-5	2019	The vitreous IL-8 level of DME patients with subretinal fluid was significantly higher than both control (p = 0.002) and DME without subretinal fluid groups (p = 0.019).	dme	121-124	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
29524030-8	2019	CONCLUSIONS: IL-8 level in vitreous samples was higher in DME patients with subretinal fluid than those without subretinal fluid, suggesting that inflammation is an important factor in the progression of DME leading to the subretinal fluid formation in diabetic patients.	dme	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
29524030-8	2019	CONCLUSIONS: IL-8 level in vitreous samples was higher in DME patients with subretinal fluid than those without subretinal fluid, suggesting that inflammation is an important factor in the progression of DME leading to the subretinal fluid formation in diabetic patients.	dme	204-207	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
31010609-10	2019	Dexamethasone, but not maxacalcitol nor the phosphodiesterase 4 inhibitor apremilast, partially inhibited the CXCL8 and CCL20 secretion.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	110-115
30213848-1	2019	Coronary 18F-sodium fluoride (18F-NaF) PET identifies ruptured plaques in patients with recent myocardial infarction and localizes to atherosclerotic lesions with active calcification.	18f-sodium fluoride	9-28	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
30295316-13	2019	G-HSA or HSA when combined with IL-1beta or IL-1beta + IL-17 synergistically stimulated IL-6 and IL-8.	g-hsa	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
30295316-16	2019	Vitamin D inhibited IL-6 and IL-8 production stimulated by G-HSA or HSA + IL-1beta or IL-1beta + IL-17.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
30726064-5	2019	The CXCL8-Arg6His analogue stimulated calcium release, phosphorylation of ERK1/2, and chemotaxis in cells expressing CXCR1.	Calcium	38-45	C-X-C motif chemokine ligand 8	Homo sapiens	4-9
30794923-11	2019	Ibuprofen-acyl glucuronide, but not ibuprofen, inhibited the release of IL-8 evoked by AITC from cultured bronchial epithelial cells.	Ibuprofen	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
30794923-11	2019	Ibuprofen-acyl glucuronide, but not ibuprofen, inhibited the release of IL-8 evoked by AITC from cultured bronchial epithelial cells.	acyl glucuronide	10-26	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
30769285-8	2019	The mechanical study revealed that tumoral NOX4-induced reactive oxygen species (ROS) stimulated various cytokine production, including CCL7, IL8, CSF-1 and VEGF-C, via PI3K/Akt signaling-dependent manner.	Reactive Oxygen Species	56-79	C-X-C motif chemokine ligand 8	Homo sapiens	142-145
30769285-8	2019	The mechanical study revealed that tumoral NOX4-induced reactive oxygen species (ROS) stimulated various cytokine production, including CCL7, IL8, CSF-1 and VEGF-C, via PI3K/Akt signaling-dependent manner.	Reactive Oxygen Species	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	142-145
30677406-2	2019	HAT enhanced release of interleukin-8 (IL-8) from HBECs at 10-100 mU/mL and the enhanced release was almost completely abolished by 50 muM leupeptin, a serine protease inhibitor.	leupeptin	139-148	C-X-C motif chemokine ligand 8	Homo sapiens	24-37
30677406-2	2019	HAT enhanced release of interleukin-8 (IL-8) from HBECs at 10-100 mU/mL and the enhanced release was almost completely abolished by 50 muM leupeptin, a serine protease inhibitor.	leupeptin	139-148	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
30677406-2	2019	HAT enhanced release of interleukin-8 (IL-8) from HBECs at 10-100 mU/mL and the enhanced release was almost completely abolished by 50 muM leupeptin, a serine protease inhibitor.	Serine	152-158	C-X-C motif chemokine ligand 8	Homo sapiens	24-37
30677406-2	2019	HAT enhanced release of interleukin-8 (IL-8) from HBECs at 10-100 mU/mL and the enhanced release was almost completely abolished by 50 muM leupeptin, a serine protease inhibitor.	Serine	152-158	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
30409612-4	2019	When lycopene was paired with the methoxylated anthocyanins, the anti-inflammatory effect on the inhibition of the cytokine IL-8, which is a pro-inflammatory biomarker, was increased by 15-69% of the expected additive activity, indicating synergistic interaction between the compounds.	Lycopene	5-13	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
30409612-4	2019	When lycopene was paired with the methoxylated anthocyanins, the anti-inflammatory effect on the inhibition of the cytokine IL-8, which is a pro-inflammatory biomarker, was increased by 15-69% of the expected additive activity, indicating synergistic interaction between the compounds.	Anthocyanins	47-59	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
30716336-7	2019	Our study proved that exosomes arising from KG1A cells could propel BMSCs to generate IL-8, which could regulate the effect of etoposide treatment.	Etoposide	127-136	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
30716336-8	2019	Furthermore, IL-8 inhibition by its antibody increased the sensitivity of AML cells to cell death triggered via etoposide.	Etoposide	112-121	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
30871567-12	2019	The levels of TNF-a, IL-6, and IL-8 were positively correlated with increases in BMI, serum glucose and cholesterol levels.	Glucose	92-99	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
30871567-12	2019	The levels of TNF-a, IL-6, and IL-8 were positively correlated with increases in BMI, serum glucose and cholesterol levels.	Cholesterol	104-115	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
30867499-0	2019	The BRAF-inhibitor PLX4720 inhibits CXCL8 secretion in BRAFV600E mutated and normal thyroid cells: a further anti-cancer effect of BRAF-inhibitors.	PLX 4720	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	36-41
30767051-8	2019	In contrast, while the silica response was not augmented in the A549 cells by the addition of iron oxide, iron oxide particles alone were sufficient to induce IL-8 production in these cells.	ferric oxide	106-116	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
30797069-0	2019	Sinomenine inhibits osteolysis in breast cancer by reducing IL-8/CXCR1 and c-Fos/NFATc1 signaling.	sinomenine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
30984167-15	2019	Peficitinib decreased also the MMP-3, CXCL8, and CXCL1 release at 5 muM.	peficitinib	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	38-43
31061956-6	2019	Spearman correlations of change of an immune marker from baseline to day 90 with change in serum bilirubin revealed that an increase in total bilirubin correlated with 1) increased percentage of HLA-DR+CD38+ NK cells and expression of NK cell activation markers CD69 and HLA-DR, 2) decreased percentage of regulatory T cells, and 3) increased interleukin (IL)-8 and associated neutrophil products (elastase and neutrophil extracellular traps).	Bilirubin	142-151	C-X-C motif chemokine ligand 8	Homo sapiens	343-361
30936860-9	2019	Treatment of differentiated Caco-2 cells monolayer with BGZLS10-17 supernatant containing GABA alleviated inflammation (production of IL-8) caused by IL-1beta and significantly stimulated the expression of tight junction proteins (zonulin, occludin, and claudin 4), as well as the expression of TGF-beta cytokine leading to the conclusion that immunosuppression and strengthening the tight junctions can have significant role in the maintenance of intestinal epithelial barrier integrity.	gamma-Aminobutyric Acid	90-94	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
30972180-6	2019	PA significantly increased several markers of the inflammatory and profibrotic process including gene expression of collagens, alpha-sma, tissue inhibitor of matrix metalloprotease 1 (timp1) and the stellate cell activation marker pdgfrbeta as well as secreted CXCL8 (IL8) levels.	Palmitic Acid	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	261-266
30972180-6	2019	PA significantly increased several markers of the inflammatory and profibrotic process including gene expression of collagens, alpha-sma, tissue inhibitor of matrix metalloprotease 1 (timp1) and the stellate cell activation marker pdgfrbeta as well as secreted CXCL8 (IL8) levels.	Palmitic Acid	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	268-271
31057757-4	2019	Here we present an extremely simple approach to introduce a compact NaF-rich interphase on a Na surface via chemical reactions between fluoroethylene carbonate-Na+ and Na metal, resulting in a compatible Na anode/SN-based electrolyte interface.	4-fluoro-1,3-dioxolan-2-one	135-159	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
30726064-7	2019	The CXCL8-Glu4AlaLeu5AlaArg6His analogue was inactive in cells expressing CXCR1 and CXCR2.	glu4alaleu5alaarg6his	10-31	C-X-C motif chemokine ligand 8	Homo sapiens	4-9
31057757-4	2019	Here we present an extremely simple approach to introduce a compact NaF-rich interphase on a Na surface via chemical reactions between fluoroethylene carbonate-Na+ and Na metal, resulting in a compatible Na anode/SN-based electrolyte interface.	na metal	168-176	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
30726064-8	2019	These findings suggest that the Glu4Leu5 motif in CXCL8 is essential for activation of CXCR1 and CXCR2.	glu4leu5	32-40	C-X-C motif chemokine ligand 8	Homo sapiens	50-55
31057757-4	2019	Here we present an extremely simple approach to introduce a compact NaF-rich interphase on a Na surface via chemical reactions between fluoroethylene carbonate-Na+ and Na metal, resulting in a compatible Na anode/SN-based electrolyte interface.	succinonitrile	213-215	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
31057757-5	2019	The in situ formed NaF-rich interphase can not only prevent side reactions between the SN-based electrolyte and Na anode but also regulate the uniform deposition of dendrite-free Na.	sn-based electrolyte	87-107	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
30726064-9	2019	Importantly, CXCL8-Glu4AlaLeu5AlaArg6His blocked specifically the calcium release and chemotaxis of cells expressing CXCR1 but not of cells expressing CXCR2.	Calcium	66-73	C-X-C motif chemokine ligand 8	Homo sapiens	13-18
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	Zinc	46-50	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	Zinc	46-50	C-X-C motif chemokine ligand 8	Homo sapiens	166-171
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	Zinc	46-50	C-X-C motif chemokine ligand 8	Homo sapiens	166-171
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	Calcium	119-126	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	Calcium	119-126	C-X-C motif chemokine ligand 8	Homo sapiens	166-171
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	Calcium	119-126	C-X-C motif chemokine ligand 8	Homo sapiens	166-171
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	zinc chloride	139-144	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	zinc chloride	139-144	C-X-C motif chemokine ligand 8	Homo sapiens	166-171
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	zinc chloride	139-144	C-X-C motif chemokine ligand 8	Homo sapiens	166-171
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	Calcium	188-195	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	Calcium	188-195	C-X-C motif chemokine ligand 8	Homo sapiens	166-171
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	Calcium	188-195	C-X-C motif chemokine ligand 8	Homo sapiens	166-171
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	Calcium	188-195	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	Calcium	188-195	C-X-C motif chemokine ligand 8	Homo sapiens	166-171
30726064-11	2019	The binding of CXCL8-ELR6H to CXCR1 created a Zn2+ coordination site at the receptor activation domain responsible for calcium release, as ZnCl2 specifically blocked CXCL8-Arg6His-induced calcium release without affecting CXCL8-induced calcium release.	Calcium	188-195	C-X-C motif chemokine ligand 8	Homo sapiens	166-171
30857165-1	2019	18F-Sodium Fluoride (NaF) accumulates in areas of active hydroxyapatite deposition and potentially unstable atherosclerotic plaques.	18f-sodium fluoride	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
30832675-11	2019	This change in GSK-3 activity decreased the C/EBPss phosphorylation levels of the threonine 235, a residue whose phosphorylation is known to increase C/EBPss transactivation potential, and consequently modified IL-8 expression.	Threonine	82-91	C-X-C motif chemokine ligand 8	Homo sapiens	211-215
30915077-5	2019	PMA-induced NETs were decorated with annexins, azurocidin and histone H3, whereas A23187-induced NETs were decorated with granule proteins including CAMP/LL37, CRISP3, lipocalin and MMP8, histones H1.0, H1.4, and H1.5, interleukin-8, protein-arginine deiminase-4 (PADI4), and alpha-enolase.	Calcimycin	82-88	C-X-C motif chemokine ligand 8	Homo sapiens	219-232
30866458-9	2019	In particular, menadione inhibited nuclear factor kappa-light-chain-enhancer of activated B cell (NF-kappaB) activation and thereby reduced expression of the proinflammatory cytokines such as IL-1beta, IL-6, IL-8, and TNF-alpha in AGS as well as in THP-1 (monocytic leukemia cell) cell lines.	Vitamin K 3	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
30866565-5	2019	Several fatty acids were associated with interferon-gamma (IFNgamma) and interleukins (ILs) IL-6, IL-8, and IL-10 at baseline and additionally also with IL-1b at 1 year.	Fatty Acids	8-19	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
30866565-6	2019	Omega-6 fatty acids were consistently positively associated with pro-inflammatory IL-6 and IL-8 at baseline.	Fatty Acids, Omega-6	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
30341773-10	2019	CONCLUSION: Resting salivary flow rate was significantly reduced in head-and-neck cancer patients following radiotherapy and use of CPP-ACP with SnF2 /NaF significantly lowered caries progression compared with SnF2 /NaF alone.	cpp-acp	132-139	C-X-C motif chemokine ligand 8	Homo sapiens	151-154
30553868-6	2019	IL-8 secretion was inhibited by intracellular TLR4-domain antagonist TAK-242 with an IC50-value of 259.6 nM, by ecto-domain TLR4 antagonistic mianserin with 10-51 muM and by anti-CD14-IgA.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	69-76	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
30659323-3	2019	Here in human neuroblastoma SH-SY5Y cells treated with sodium fluoride (NaF, 20, 40 and 60 mg/L), mitochondrial fission suppression exerted a central role in NaF-induced mitochondrial abnormalities and the resulting autophagy deficiency, apoptosis augmentation, and compromised neuronal survival.	Sodium Fluoride	55-70	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
30659323-3	2019	Here in human neuroblastoma SH-SY5Y cells treated with sodium fluoride (NaF, 20, 40 and 60 mg/L), mitochondrial fission suppression exerted a central role in NaF-induced mitochondrial abnormalities and the resulting autophagy deficiency, apoptosis augmentation, and compromised neuronal survival.	Sodium Fluoride	55-70	C-X-C motif chemokine ligand 8	Homo sapiens	158-161
30659323-7	2019	Consistently, using Sprague-Dawley rats developmentally exposed to NaF (10, 50, and 100 mg/L) from pre-pregnancy until 2 months of delivery to mimic human exposure, we showed that perinatal exposure to environmentally relevant levels of fluoride caused learning and memory impairments, accompanied by hippocampal mitochondrial morphological alterations manifested as fission suppression and fusion acceleration, along with defective autophagy, excessive apoptosis and neuronal loss.	Fluorides	237-245	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
30626802-5	2019	Consistent with decreased expression of TLR2, PGN-dependent interleukin-8 (IL-8) gene up-regulation was markedly reduced by 40 microM of curcumin treatment.	Curcumin	137-145	C-X-C motif chemokine ligand 8	Homo sapiens	60-73
30594784-6	2019	The addition of zafirlukast to culture media suppressed TNF-alpha-induced expression of endothelial vascular adhesion molecules, such as ICAM-1, VCAM-1, and induction of cytokines, including IL-1beta, IL-6, and IL-8.	zafirlukast	16-27	C-X-C motif chemokine ligand 8	Homo sapiens	211-215
30626802-5	2019	Consistent with decreased expression of TLR2, PGN-dependent interleukin-8 (IL-8) gene up-regulation was markedly reduced by 40 microM of curcumin treatment.	Curcumin	137-145	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
30265130-11	2019	A statistically significant decrease in IL-8 was noted for all TiO2NP at the highest concentrations due to the adsorption of IL-8 by TiO2.	tio2np	63-69	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
30944833-7	2019	Furthermore, OCT reduced both pro- and anti-inflammatory mediators (IL-8, IL-33, and IL-10), while angiogenesis and growth factor mediators (VEGF and TGF-beta1) remained unchanged in skin explant cultures.	octenidine	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
30148447-2	2019	This study determined monosodium urate crystal-induced MIF production and its interaction with interleukin (IL)-8 in gout.	Uric Acid	22-38	C-X-C motif chemokine ligand 8	Homo sapiens	95-113
30265130-11	2019	A statistically significant decrease in IL-8 was noted for all TiO2NP at the highest concentrations due to the adsorption of IL-8 by TiO2.	tio2np	63-69	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
30478770-7	2019	Multiple linear regression models predicted significant association between transcript levels of Ki-67, NF-kB (p65), PPARgamma, COX-2 and IL-8, CDC25A, and CXCL10 with duration of drug (5-ASA) exposure (P &lt;= 0.05).	Mesalamine	186-191	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
30265130-11	2019	A statistically significant decrease in IL-8 was noted for all TiO2NP at the highest concentrations due to the adsorption of IL-8 by TiO2.	titanium dioxide	63-67	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
30265130-11	2019	A statistically significant decrease in IL-8 was noted for all TiO2NP at the highest concentrations due to the adsorption of IL-8 by TiO2.	titanium dioxide	63-67	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
30354488-4	2019	The p65 subunit of NF-kappaB was translocated into the nucleus of the cells treated with 100 microg mL-1 PM2.5 at 6 and 24 h. Bay11-7082 partly inhibited PM2.5-induced increases of IL-6 and IL-8 secretion.	3-(4-methylphenylsulfonyl)-2-propenenitrile	126-136	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
30964194-10	2019	The cytoprotective effects of SDX resulted from a reduction in a) ROS production, b) neo-synthesis and release of pro-inflammatory cytokines (TNFalpha, IL1, IL6, IL8), c) DNA damage induced by MGO or IR.	glucuronyl glucosamine glycan sulfate	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	162-165
30783447-8	2019	Notably, IL-8 was positively correlated with AHI, morning systolic and diastolic pressure (r=0.337, 0.413 and 0.629; P&lt;0.05), and negatively correlated with MSaO2 and LSaO2 (r=-0.329 and -0.417; P&lt;0.05).	msao2	160-165	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
30783447-8	2019	Notably, IL-8 was positively correlated with AHI, morning systolic and diastolic pressure (r=0.337, 0.413 and 0.629; P&lt;0.05), and negatively correlated with MSaO2 and LSaO2 (r=-0.329 and -0.417; P&lt;0.05).	lsao2	170-175	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
31777853-1	2019	Objectives: This study aimed to assess the effect of 0.05% sodium fluoride (NaF) mouthwash on the surface roughness and friction between ceramic brackets and rhodium-coated (RC) and uncoated stainless steel (SS) wires.	Sodium Fluoride	59-74	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
31777853-1	2019	Objectives: This study aimed to assess the effect of 0.05% sodium fluoride (NaF) mouthwash on the surface roughness and friction between ceramic brackets and rhodium-coated (RC) and uncoated stainless steel (SS) wires.	Rhodium	158-165	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
30443903-0	2019	L-selectin expression is regulated by CXCL8-induced reactive oxygen species produced during human neutrophil rolling.	Reactive Oxygen Species	52-75	C-X-C motif chemokine ligand 8	Homo sapiens	38-43
30443903-4	2019	Flow experiments using dihydroethidium-preloaded human neutrophils showed that these cells initiate an early production of intracellular ROS during the rolling phase of the adhesion cascade, a phenomenon that required cell rolling, and the interaction of the chemokine receptor CXCR2 with their ligand CXCL8.	dihydroethidium	23-38	C-X-C motif chemokine ligand 8	Homo sapiens	302-307
30443903-4	2019	Flow experiments using dihydroethidium-preloaded human neutrophils showed that these cells initiate an early production of intracellular ROS during the rolling phase of the adhesion cascade, a phenomenon that required cell rolling, and the interaction of the chemokine receptor CXCR2 with their ligand CXCL8.	Reactive Oxygen Species	137-140	C-X-C motif chemokine ligand 8	Homo sapiens	302-307
30443903-8	2019	These findings indicate that, in response to CXCL8, neutrophils initiate ROS production during the rolling phase of the inflammatory response.	Reactive Oxygen Species	73-76	C-X-C motif chemokine ligand 8	Homo sapiens	45-50
30059697-8	2019	A 30% increase in IL-8 suppression by FLU (P = .04) and a trend for increased TNF-alpha suppression by FLU between V0 and V6 (P = .07) were observed in patients with easy-to-control asthma.	Fluticasone	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
30686699-9	2019	Patients treated with azithromycin demonstrated less airway inflammation, with lower bronchoalveolar lavage (BAL) neutrophilia and BAL interleukin-8 protein levels at Day 30 (p = 0.09 and p = 0.04, respectively) and Day 90 (p = 0.002 and p = 0.08, respectively) after LTx.	Azithromycin	22-34	C-X-C motif chemokine ligand 8	Homo sapiens	135-148
30378164-12	2019	In HCT 116 cells stimulated with TNF-alpha, TUDCA significantly inhibited IL-8 and IL-1alpha expression and suppressed TNF-alpha-induced IkappaBalpha phosphorylation/degradation and DNA-binding activity of NF-kappaB.	ursodoxicoltaurine	44-49	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
30761568-9	2019	Levels of IL-6 and IL-8 were significantly lower in TG than CG at 3 months.	Thioguanine	52-54	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
30569138-7	2019	Treatment of HepG2 cells for 5 h with the BA-loaded liposomes coated with chitosan at 5 mM lowered the extent of the increase in IL-8, IL-6, TNF-alpha and TGF-beta expression of approximately 64, 58, 85 and 73.8%, respectively, when compared to the untreated cells.	Butyric Acid	42-44	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
30139886-1	2019	Our objective was to test the hypothesis that variability in SUV normalized by skeletal volume (SV) in 18F-fluoride (18F-NaF) PET/CT studies is lower than variability in SUV normalized by body weight (BW).	Fluoride ion f-18	103-115	C-X-C motif chemokine ligand 8	Homo sapiens	121-124
30882648-1	2019	F-18 sodium-fluoride (NaF) bone positron emission tomography (PET/CT) has been used for diagnosing various bone and joint diseases, and, with using dual-phase scan protocol, it could give the same information obtained by the 3-phase bone scintigraphy.	Sodium Fluoride	5-20	C-X-C motif chemokine ligand 8	Homo sapiens	22-25
30519866-7	2019	Our data show that dopamine treatment of human macrophages isolated from healthy and cART-treated donors promotes production of inflammatory mediators including IL-1beta, IL-6, IL-18, CCL2, CXCL8, CXCL9, and CXCL10.	Dopamine	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	190-195
30269694-6	2019	The rapid release of CXCL-8, a preformed chemokine contained in Weibel-Palade bodies, confirmed that haemozoin induces a perturbation of the intracellular endothelial trafficking, including the exocytosis of MTT-formazan containing vesicles.	MTT formazan	208-220	C-X-C motif chemokine ligand 8	Homo sapiens	21-27
30629076-0	2019	Glycosylated naphthalimides and naphthalimide Troger"s bases as fluorescent aggregation probes for Con A. Herein we report the synthesis of fluorescent, glycosylated 4-amino-1,8-naphthalimide (Nap) 1, and the related 1,8-naphthalimides Troger"s bases (TBNap) 2 and 3, from 1,8-naphthalic anhydride precursors, the alpha-mannosides being introduced through the use of CuAAC mediated "click" chemistry.	Naphthalimides	13-27	C-X-C motif chemokine ligand 8	Homo sapiens	166-199
30547277-10	2019	Using an ATP model of stimulation, we further demonstrated that extracellular ATP stimulation to IL-1beta containing LPS microparticles induces release of its content, which when subjected to epithelial cells induced IL-8.	Adenosine Triphosphate	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
30547277-10	2019	Using an ATP model of stimulation, we further demonstrated that extracellular ATP stimulation to IL-1beta containing LPS microparticles induces release of its content, which when subjected to epithelial cells induced IL-8.	Adenosine Triphosphate	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
30653318-0	2019	Eupatoriopicrin Inhibits Pro-inflammatory Functions of Neutrophils via Suppression of IL-8 and TNF-alpha Production and p38 and ERK 1/2 MAP Kinases.	eupatoriopicrine	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
30629076-0	2019	Glycosylated naphthalimides and naphthalimide Troger"s bases as fluorescent aggregation probes for Con A. Herein we report the synthesis of fluorescent, glycosylated 4-amino-1,8-naphthalimide (Nap) 1, and the related 1,8-naphthalimides Troger"s bases (TBNap) 2 and 3, from 1,8-naphthalic anhydride precursors, the alpha-mannosides being introduced through the use of CuAAC mediated "click" chemistry.	alpha-mannosides	314-330	C-X-C motif chemokine ligand 8	Homo sapiens	166-199
30629076-0	2019	Glycosylated naphthalimides and naphthalimide Troger"s bases as fluorescent aggregation probes for Con A. Herein we report the synthesis of fluorescent, glycosylated 4-amino-1,8-naphthalimide (Nap) 1, and the related 1,8-naphthalimides Troger"s bases (TBNap) 2 and 3, from 1,8-naphthalic anhydride precursors, the alpha-mannosides being introduced through the use of CuAAC mediated "click" chemistry.	tbnap	252-257	C-X-C motif chemokine ligand 8	Homo sapiens	166-199
30629076-0	2019	Glycosylated naphthalimides and naphthalimide Troger"s bases as fluorescent aggregation probes for Con A. Herein we report the synthesis of fluorescent, glycosylated 4-amino-1,8-naphthalimide (Nap) 1, and the related 1,8-naphthalimides Troger"s bases (TBNap) 2 and 3, from 1,8-naphthalic anhydride precursors, the alpha-mannosides being introduced through the use of CuAAC mediated "click" chemistry.	8-naphthalic anhydride	275-297	C-X-C motif chemokine ligand 8	Homo sapiens	166-199
30765785-2	2019	This study systematically reviewed the dentine caries arrest capabilities of silver diamine fluoride (SDF) and sodium fluoride (NaF).	Sodium Fluoride	111-126	C-X-C motif chemokine ligand 8	Homo sapiens	128-131
30778158-9	2019	In addition, our results indicated that iron overload enhanced the release of interleukin-8 (IL-8), a chemokine that activates neutrophils, and subsequently elevated intracellular calcium concentration ([Ca2+]i).	Iron	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	78-91
30778158-9	2019	In addition, our results indicated that iron overload enhanced the release of interleukin-8 (IL-8), a chemokine that activates neutrophils, and subsequently elevated intracellular calcium concentration ([Ca2+]i).	Iron	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
30778158-11	2019	These findings suggest that the iron overload caused by engulfed MWCNTs results in the increase of IL-8 production and the elevation of [Ca2+]i, thereby activating the mitochondria-mediated apoptotic pathway.	Iron	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
30828266-0	2019	Extracellular acidification-induced CXCL8 production through a proton-sensing receptor OGR1 in human airway smooth muscle cells: a response inhibited by dexamethasone.	Dexamethasone	153-166	C-X-C motif chemokine ligand 8	Homo sapiens	36-41
30828266-7	2019	CXCL8 secreted from ASMCs was measured by enzyme-linked immunosorbent assay (ELISA).	asmcs	20-25	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
30828266-10	2019	ASMCs transfected with small interfering RNA (siRNA) targeted for OGR1 produced less CXCL8 compared with those transfected with non-targeting siRNA.	asmcs	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	85-90
30828266-11	2019	Protein kinase C (PKC) inhibitor, MEK1/2 inhibitor, and the inhibitor of IkappaB phosphorylation reduced acidic pH-stimulated CXCL8 production in ASMCs.	asmcs	146-151	C-X-C motif chemokine ligand 8	Homo sapiens	126-131
30828266-12	2019	Dexamethasone also inhibited acidic pH-stimulated CXCL8 production of ASMCs in a dose-dependent manner.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	50-55
30828266-12	2019	Dexamethasone also inhibited acidic pH-stimulated CXCL8 production of ASMCs in a dose-dependent manner.	asmcs	70-75	C-X-C motif chemokine ligand 8	Homo sapiens	50-55
30828266-14	2019	Conclusions: CXCL8 released from ASMCs by extracellular acidification may play a pivotal role in airway accumulation of neutrophils.	asmcs	33-38	C-X-C motif chemokine ligand 8	Homo sapiens	13-18
30767218-7	2019	ALP activity, ALP protein, and messenger RNA (mRNA) expression showed that 0.5 mM was the optimal concentration for the induction of SCAPs by NaF.	scaps	133-138	C-X-C motif chemokine ligand 8	Homo sapiens	142-145
30767218-8	2019	0.5 mM NaF-treated SCAPs induced more mineralized nodules as compared with untreated cells.	scaps	19-24	C-X-C motif chemokine ligand 8	Homo sapiens	7-10
30765814-0	2019	Metformin inhibits lithocholic acid-induced interleukin 8 upregulation in colorectal cancer cells by suppressing ROS production and NF-kB activity.	Metformin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	44-57
30765814-0	2019	Metformin inhibits lithocholic acid-induced interleukin 8 upregulation in colorectal cancer cells by suppressing ROS production and NF-kB activity.	Lithocholic Acid	19-35	C-X-C motif chemokine ligand 8	Homo sapiens	44-57
30765814-0	2019	Metformin inhibits lithocholic acid-induced interleukin 8 upregulation in colorectal cancer cells by suppressing ROS production and NF-kB activity.	Reactive Oxygen Species	113-116	C-X-C motif chemokine ligand 8	Homo sapiens	44-57
30765814-2	2019	In this study, we describe the inhibitory effect of metformin in interleukin 8 (IL-8) upregulation by lithocholic acid (LCA) in HCT116 colorectal cancer (CRC) cells.	Metformin	52-61	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
30765814-2	2019	In this study, we describe the inhibitory effect of metformin in interleukin 8 (IL-8) upregulation by lithocholic acid (LCA) in HCT116 colorectal cancer (CRC) cells.	Metformin	52-61	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
30765814-2	2019	In this study, we describe the inhibitory effect of metformin in interleukin 8 (IL-8) upregulation by lithocholic acid (LCA) in HCT116 colorectal cancer (CRC) cells.	Lithocholic Acid	102-118	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
30765814-2	2019	In this study, we describe the inhibitory effect of metformin in interleukin 8 (IL-8) upregulation by lithocholic acid (LCA) in HCT116 colorectal cancer (CRC) cells.	Lithocholic Acid	102-118	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
30765814-2	2019	In this study, we describe the inhibitory effect of metformin in interleukin 8 (IL-8) upregulation by lithocholic acid (LCA) in HCT116 colorectal cancer (CRC) cells.	Lithocholic Acid	120-123	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
30765814-2	2019	In this study, we describe the inhibitory effect of metformin in interleukin 8 (IL-8) upregulation by lithocholic acid (LCA) in HCT116 colorectal cancer (CRC) cells.	Lithocholic Acid	120-123	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
30765814-3	2019	Pharmacological inhibition studies indicated that reactive oxygen species (ROS) were involved in LCA-induced IL-8 upregulation through activation of the transcription factor NF-kappaB.	Reactive Oxygen Species	50-73	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
30765814-3	2019	Pharmacological inhibition studies indicated that reactive oxygen species (ROS) were involved in LCA-induced IL-8 upregulation through activation of the transcription factor NF-kappaB.	Reactive Oxygen Species	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
30702103-6	2019	And in medium-polarity solvents, because of the relatively weaker solvation-induced stabilization of the CT state, its energy could be equal to or slightly lower than that of the LE state, leading to a smaller driving force for LE   CT interconversion; therefore complete LE   CT interconversion cannot take place.	Carbon Tetrachloride	105-107	C-X-C motif chemokine ligand 8	Homo sapiens	228-235
30765814-3	2019	Pharmacological inhibition studies indicated that reactive oxygen species (ROS) were involved in LCA-induced IL-8 upregulation through activation of the transcription factor NF-kappaB.	Lithocholic Acid	97-100	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
30765814-4	2019	Metformin was demonstrated to block LCA-stimulated ROS production, in turn suppressing NF-kappaB signaling that was critical for IL-8 upregulation.	Metformin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
30765814-4	2019	Metformin was demonstrated to block LCA-stimulated ROS production, in turn suppressing NF-kappaB signaling that was critical for IL-8 upregulation.	Lithocholic Acid	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
30765814-7	2019	In conclusion, metformin inhibited NADPH oxidase, which in turn suppressed ROS production and NF-kappaB activation to prevent IL-8 upregulation stimulated by LCA; this prevention thus obstructed endothelial cell proliferation and tubelike formation.	Metformin	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
30765814-7	2019	In conclusion, metformin inhibited NADPH oxidase, which in turn suppressed ROS production and NF-kappaB activation to prevent IL-8 upregulation stimulated by LCA; this prevention thus obstructed endothelial cell proliferation and tubelike formation.	Lithocholic Acid	158-161	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
30702103-6	2019	And in medium-polarity solvents, because of the relatively weaker solvation-induced stabilization of the CT state, its energy could be equal to or slightly lower than that of the LE state, leading to a smaller driving force for LE   CT interconversion; therefore complete LE   CT interconversion cannot take place.	Carbon Tetrachloride	105-107	C-X-C motif chemokine ligand 8	Homo sapiens	272-279
30761406-5	2019	RESULTS: SLNs provided significant encapsulation of atRA and also sustained its release over 72 h. A549 cells were viable following the addition of atRA SLNs and showed a reduction in IL-6 and IL-8 levels.	Tretinoin	148-152	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
30624061-7	2019	By using this ultrasensitive SERS-microdroplet method, the VEGF and IL-8 secretions from several cells in one droplet were explored and the data show that the cell-cell interaction may promote angiogenesis of cancer cells through the up-regulation of VEGF and IL-8.	sers	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
30809216-13	2019	Finally, PGE2 treatment in THP-1 cells triggered downmodulation of pro-inflammatory mediators and upregulation of IL-8 and IL-10.	Dinoprostone	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
30733507-4	2019	Long-term treatment of olanzapine caused metabolic symptoms, including IR, by markedly elevating the plasma levels of pro-inflammatory cytokines, including IL-1ss, IL-6, IL-8 and TNFalpha; these findings are consistent with observations from schizophrenia patients chronically treated with olanzapine.	Olanzapine	23-33	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
30719765-6	2019	The results showed that erlotinib alleviated CXCL8-induced metastasis of the colon cancer cells.	Erlotinib Hydrochloride	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	45-50
30624061-7	2019	By using this ultrasensitive SERS-microdroplet method, the VEGF and IL-8 secretions from several cells in one droplet were explored and the data show that the cell-cell interaction may promote angiogenesis of cancer cells through the up-regulation of VEGF and IL-8.	sers	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	260-264
30580559-3	2019	Approach and Results- We performed coronary atherosclerosis with 18F-sodium fluoride (NaF) positron emission tomography/computed tomography and gated chest computed tomography for coronary artery calcium in 88 consecutive ambulatory patients with DM on a stable medical regimen.	18f-sodium fluoride	65-84	C-X-C motif chemokine ligand 8	Homo sapiens	86-89
30549424-7	2019	By maintaining the same topology as the parental cells, these dexamethasone-loaded ghost nanovesicles derived from human U937 monocytes reduce the release of interleukin-8 from OMV-treated endothelial cells in vitro, and mitigate the symptoms of OMV-induced SIRS in vivo.	Dexamethasone	62-75	C-X-C motif chemokine ligand 8	Homo sapiens	158-171
30549424-7	2019	By maintaining the same topology as the parental cells, these dexamethasone-loaded ghost nanovesicles derived from human U937 monocytes reduce the release of interleukin-8 from OMV-treated endothelial cells in vitro, and mitigate the symptoms of OMV-induced SIRS in vivo.	1-ethylcyclopentyl [(2R,6S,12Z,13aS,14aR,16aS)-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl]carbamate	177-180	C-X-C motif chemokine ligand 8	Homo sapiens	158-171
30580559-5	2019	NaF activity was measured as target (coronary arteries)-to-background (left ventricular pool) ratio (TBR).	tbr	101-104	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
30340750-0	2019	The clinical significance of incidental soft tissue uptake on whole body 18F-sodium fluoride bone PET-CT. 18F-sodium fluoride (NaF) is a PET bone imaging agent and is commonly used in imaging patients with cancer; however, similar to technetium-99m medronic acid (99mTc-MDP), it can be useful in the evaluation of benign bone and joint conditions.	Sodium Fluoride	77-92	C-X-C motif chemokine ligand 8	Homo sapiens	127-130
30312114-5	2019	In human myometrial cells, simvastatin reduced proinflammatory mediator mRNA and protein expression (IL-6 and IL-8) and increased anti-inflammatory cytokine mRNA expression (IL-10 and IL-13).	Simvastatin	27-38	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
30622078-9	2019	Additionally, peripheral counts of white blood cells, and the concentrations of interleukin-8 and tumor necrosis factor-alpha, in Guiyu children were greater than in Haojiang children, and were positively associated with CDI.	1,1'-Carbonyldiimidazole	221-224	C-X-C motif chemokine ligand 8	Homo sapiens	80-125
30585659-6	2019	We demonstrate that dapsone suppresses production of specific cytokine signatures interleukin (IL)1alpha and IL8 in human epidermal keratinocytes and IL1beta, IL6, IL8 and tumor necrosis factor-alpha in THP-1 cells in response to P. acnes.	Dapsone	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	109-112
29512317-1	2019	FOCUS QUESTION: What is the efficacy of a chlorhexidine (CHX) mouthwash (MW) containing sodium fluoride (NaF) compared to a CHX - MW alone on the parameters of plaque, gingivitis and discoloration?	Chlorhexidine	42-55	C-X-C motif chemokine ligand 8	Homo sapiens	105-108
30698875-8	2019	Furthermore, CPs caused alterations of mRNA expression levels of dermal matrix-related proteins, such as upregulating MMP-1 and IL-8.	cps	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
29512317-1	2019	FOCUS QUESTION: What is the efficacy of a chlorhexidine (CHX) mouthwash (MW) containing sodium fluoride (NaF) compared to a CHX - MW alone on the parameters of plaque, gingivitis and discoloration?	Sodium Fluoride	88-103	C-X-C motif chemokine ligand 8	Homo sapiens	105-108
29512317-1	2019	FOCUS QUESTION: What is the efficacy of a chlorhexidine (CHX) mouthwash (MW) containing sodium fluoride (NaF) compared to a CHX - MW alone on the parameters of plaque, gingivitis and discoloration?	Chlorhexidine	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	105-108
30378182-10	2019	Following inflammatory stimulation and treatment with ASA CM, tenocytes downregulated IL-8 gene expression, a pro-inflammatory cytokine normally elevated during the inflammatory phase of tendon healing.	Aspirin	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
30078219-5	2019	Further, significant increase in phosphorylation of signal transducer and activator of transcription 1 (STAT-1) and STAT-3 (both at ser727 residue) is observed on treating HTR-8/SVneo cells with 25 microM of H2 O2 accompanied by an increase in the secretion of interleukin-8 (IL-8) and macrophage inflammatory protein-1beta (MIP-1beta).	Hydrogen Peroxide	208-213	C-X-C motif chemokine ligand 8	Homo sapiens	261-274
30078219-5	2019	Further, significant increase in phosphorylation of signal transducer and activator of transcription 1 (STAT-1) and STAT-3 (both at ser727 residue) is observed on treating HTR-8/SVneo cells with 25 microM of H2 O2 accompanied by an increase in the secretion of interleukin-8 (IL-8) and macrophage inflammatory protein-1beta (MIP-1beta).	Hydrogen Peroxide	208-213	C-X-C motif chemokine ligand 8	Homo sapiens	276-280
30078219-6	2019	A significant decrease in H2 O2 -mediated invasion of HTR-8/SVneo cells and reduced expression of IL-8 and MIP-1beta accompanied by decrease in MMP-9/TIMP-1 ratio are observed on inhibiting STAT-1 and STAT-3 by small interfering RNA (siRNA).	Hydrogen Peroxide	26-31	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
30078219-8	2019	Inhibition of IL-8 and MIP-1beta by siRNA also leads to a significant decrease in both basal and H2 O2 -mediated invasion.	Hydrogen Peroxide	97-102	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
30078219-9	2019	Interestingly, inhibition of MIP-1beta by siRNA leads to a significant reduction in H2 O2 -mediated increase in IL-8.	Hydrogen Peroxide	84-89	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
30078219-11	2019	From the above results, it can be concluded that H2 O2 activates STAT signaling, MIP-1beta &amp; IL-8 secretion and increases MMP-9/TIMP-1 ratio leading to an increased invasion of HTR-8/SVneo cells without affecting their viability.	Hydrogen Peroxide	49-54	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
30553912-5	2019	In addition, we found that the mRNA expression of IL-1beta, IL-6, IL-8 and IL-17A were markedly down-regulated by treatment with betulinic acid in TNF-alpha-induced RA FLSs.	betulinic acid	129-143	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
30305725-0	2019	IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells.	o-glcnac	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
30476578-5	2019	The results demonstrated that plantamajoside decreased the production of PGE2, NO, IL-6, and IL-8 in LPS-stimulated HGFs.	plantamajoside	30-44	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
30030777-6	2019	Nicotine, 4-NQO, and their combinational applications with Pg LPS induced the secretions of IL-1beta and IL-1Ra, while that of IL-8 was inhibited by the presence of Pg LPS.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
30030777-6	2019	Nicotine, 4-NQO, and their combinational applications with Pg LPS induced the secretions of IL-1beta and IL-1Ra, while that of IL-8 was inhibited by the presence of Pg LPS.	4-Nitroquinoline-1-oxide	10-15	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
30305725-6	2019	We also showed that IL-8 stimulation of colon and lung cancer cells-induced glucose uptake and expressions of glucose transporter 3 (GLUT3) and glucosamine fructose-6-phosphate aminotransferase (GFAT), a regulator of glucose flux to the hexosamine biosynthetic pathway, resulting in enhancement of protein O-GlcNAcylation.	Glucose	76-83	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
30305725-6	2019	We also showed that IL-8 stimulation of colon and lung cancer cells-induced glucose uptake and expressions of glucose transporter 3 (GLUT3) and glucosamine fructose-6-phosphate aminotransferase (GFAT), a regulator of glucose flux to the hexosamine biosynthetic pathway, resulting in enhancement of protein O-GlcNAcylation.	Glucose	110-117	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
30305725-6	2019	We also showed that IL-8 stimulation of colon and lung cancer cells-induced glucose uptake and expressions of glucose transporter 3 (GLUT3) and glucosamine fructose-6-phosphate aminotransferase (GFAT), a regulator of glucose flux to the hexosamine biosynthetic pathway, resulting in enhancement of protein O-GlcNAcylation.	Hexosamines	237-247	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
30719005-5	2018	Oleic acid alone had opposite effects due to its different capacity of controlling these metabolic pathways, in particular by reduction of the ROS levels and MMP-2 activity, down-regulation of BiP, eIF2alpha, ATF6, XBP1u, CHOP, IL6, IL8 and by SOD2 and PTP-1B overexpression.	Oleic Acid	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	233-236
30674715-7	2019	Furthermore, GL-2045 administration to nonhuman primates (NHPs) transiently increased systemic levels of the antiinflammatory cytokines IL-10 and IL-1RA, reduced the proinflammatory cytokine IL-8, and decreased surface expression of CD14 and HLA-DR on monocytes.	glycylleucine	13-15	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
30592197-8	2019	The NaF/KF-PDT-induced changes in the HAXPES spectra for different alkali exposures are best reproduced by additional contributions from KInSe2, with some indications that the formation of a pronounced K-In-Se-type surface species might crucially depend on the amount of K available during PDT.	Selenium	140-142	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
30247740-4	2019	TVX inhibited find-me signal release in apoptotic HepG2 hepatocytes, decelerated freshly isolated human neutrophils toward IL-8 and f-MLF, and decreased the liver expression of ICAM-1.	trovafloxacin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
30782274-9	2019	TAK-242 inhibited the mRNA and protein expression of TLR4 and NF-kappaB and mRNA expression of IL-8 (P&lt;0.05).	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
30782274-12	2019	Glycyrrhizin inhibited the mRNA expression of HMGB1 and the mRNA and protein expression of TLR4 and NF-kappaB and then reduced the mRNA expression of IL-8 (P&lt;0.05).	Glycyrrhizic Acid	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
30670536-6	2019	Platelets treated with aspirin did not activate the Akt pathway, resulting in reduced IL-8 secretion and impaired tumor cell invasion.	Aspirin	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
30670536-7	2019	Of note, patients with breast cancer receiving aspirin had lower circulating IL-8, and their platelets did not increase tumor cell invasion compared with patients not receiving aspirin.	Aspirin	47-54	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
30719005-6	2018	The supplementation of saturated palmitic acid with the monounsaturated oleic acid reversed the negative effects of palmitic acid alone regulating insulin secretion from pancreatic beta cells through ROS, MMP-2, ATF6, XBP1u, IL8 reduction and SOD2, PTP-1B activation.	saturated palmitic acid	23-46	C-X-C motif chemokine ligand 8	Homo sapiens	225-228
30719005-6	2018	The supplementation of saturated palmitic acid with the monounsaturated oleic acid reversed the negative effects of palmitic acid alone regulating insulin secretion from pancreatic beta cells through ROS, MMP-2, ATF6, XBP1u, IL8 reduction and SOD2, PTP-1B activation.	monounsaturated oleic acid	56-82	C-X-C motif chemokine ligand 8	Homo sapiens	225-228
30719005-6	2018	The supplementation of saturated palmitic acid with the monounsaturated oleic acid reversed the negative effects of palmitic acid alone regulating insulin secretion from pancreatic beta cells through ROS, MMP-2, ATF6, XBP1u, IL8 reduction and SOD2, PTP-1B activation.	Palmitic Acid	33-46	C-X-C motif chemokine ligand 8	Homo sapiens	225-228
30687301-8	2018	Levels of pro-inflammatory cytokines IL-8 and TNFalpha were also increased in DHF patients as compared with those in healthy and DF subjects.	dhf	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
30646963-0	2019	Genistein inhibits stemness of SKOV3 cells induced by macrophages co-cultured with ovarian cancer stem-like cells through IL-8/STAT3 axis.	Genistein	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
30646963-7	2019	Moreover, depletion or addition of IL-8 enhanced or attenuated the effect of GEN. Additionally, knockdown or overepression of STAT3 in THP-1 macrophages potentiated or attenuated the inhibitory effects of GEN.	Genistein	77-80	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
30622698-6	2019	In vitro experiments demonstrated that PLAG inhibited NADPH oxidase 2 (NOX2)-mediated reactive oxygen species production induced by gemcitabine, which is the upstream of MIP-2 and/or CXCL8.	gemcitabine	132-143	C-X-C motif chemokine ligand 8	Homo sapiens	183-188
30397077-5	2019	When senescent, luminal cells activated stromal fibroblasts in an IL-8-dependent manner, through the activation of the STAT3 pathway.	Phenobarbital	16-23	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
30397077-7	2019	These results show the role of senescent breast luminal cells in promoting the inflammatory/carcinogenic microenvironment through the activation of fibroblasts in an IL-8-dependent manner.	Phenobarbital	48-55	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
29929938-0	2019	PGE2 enhanced TNFalpha-mediated IL-8 induction in monocytic cell lines and PBMC.	Dinoprostone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
30407866-6	2019	On the contrary, challenge with supraphysiological concentrations (10-25 mM), as might be used therapeutically, of propionate or butyrate in combination with TNFalpha resulted in substantially greater IL-6 and CXCL8 release from HLFs and ASM cells than challenge with TNFalpha alone, demonstrating synergistic effects.	Propionates	115-125	C-X-C motif chemokine ligand 8	Homo sapiens	210-215
30384152-10	2019	Intriguingly, both resveratrol and JNK inhibitor SP600125 suppressed TNFalpha-induced IL6 and IL8 mRNA expression (P &lt; 0.05).	Resveratrol	19-30	C-X-C motif chemokine ligand 8	Homo sapiens	94-97
30384152-10	2019	Intriguingly, both resveratrol and JNK inhibitor SP600125 suppressed TNFalpha-induced IL6 and IL8 mRNA expression (P &lt; 0.05).	pyrazolanthrone	49-57	C-X-C motif chemokine ligand 8	Homo sapiens	94-97
30521103-0	2019	Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL-33.	Chondroitin Sulfates	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	50-55
30521103-5	2019	Preincubation with CS had no effect on MC degranulation stimulated by SP, but inhibited TNF (60%) and CXCL8 (45%) secretion from LAD2 cells stimulated by IL-33.	Chondroitin Sulfates	19-21	C-X-C motif chemokine ligand 8	Homo sapiens	102-107
30521103-12	2019	The findings in this article show that CS inhibits secretion of TNF and CXCL8 from human cultured MC stimulated by IL-33.	Chondroitin Sulfates	39-41	C-X-C motif chemokine ligand 8	Homo sapiens	72-77
31582650-4	2019	2FL reduced PM10-induced excess expression of interleukin (IL)-6, IL-8, IL-1alpha and IL-1beta in HaCaT keratinocytes.	2'-fucosyllactose	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
29874648-1	2019	This study investigated the effect of surfactants associated with sodium fluoride (NaF) on enamel erosion prevention, using an erosion-remineralization in vitro model.	Sodium Fluoride	66-81	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
30520054-4	2019	Our results demonstrated that metformin significantly decreased the mRNA and protein levels of tumour necrosis factor-alpha (TNFalpha), interleukin (IL)-6, IL-8, and IL-1beta induced by TNFalpha.	Metformin	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
30314969-7	2019	TSH significantly upregulated VEGF-A and CXCL8 expressions in BHP10-3SCp cells via AKT and ERK signaling, resulting in higher concentrations of VEGF-A and CXCL8 in conditioned medium of TSH-treated BHP10-3SCp cells (TSH-CM) compared with controls.	Thyrotropin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	41-46
30314969-7	2019	TSH significantly upregulated VEGF-A and CXCL8 expressions in BHP10-3SCp cells via AKT and ERK signaling, resulting in higher concentrations of VEGF-A and CXCL8 in conditioned medium of TSH-treated BHP10-3SCp cells (TSH-CM) compared with controls.	Thyrotropin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	155-160
30314969-7	2019	TSH significantly upregulated VEGF-A and CXCL8 expressions in BHP10-3SCp cells via AKT and ERK signaling, resulting in higher concentrations of VEGF-A and CXCL8 in conditioned medium of TSH-treated BHP10-3SCp cells (TSH-CM) compared with controls.	Thyrotropin	186-189	C-X-C motif chemokine ligand 8	Homo sapiens	41-46
30314969-7	2019	TSH significantly upregulated VEGF-A and CXCL8 expressions in BHP10-3SCp cells via AKT and ERK signaling, resulting in higher concentrations of VEGF-A and CXCL8 in conditioned medium of TSH-treated BHP10-3SCp cells (TSH-CM) compared with controls.	Thyrotropin	186-189	C-X-C motif chemokine ligand 8	Homo sapiens	155-160
30314969-8	2019	TSH-CM treatment enhanced tube formation potentials of endothelial cells, and blocking VEGF and/or CXCL8 reduced them.	Thyrotropin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	99-104
30314969-9	2019	Blocking VEGF and/or CXCL8 also reduced TSH-dependent tumor growth with reduced tumor vasculature in vivo.	Thyrotropin	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	21-26
29934049-8	2019	Analysis in vitro by MTT test and Boyden chamber assay showed exogenous IL-6 and IL-8 (a relatively short period of treatment with recombinant IL-6 or IL-8 equivalent to the autocrine levels) could significantly promote the proliferation of human osteoblastic, endothelial and monocytic cells, as well as the migration of human endothelial cells.	monooxyethylene trimethylolpropane tristearate	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
30844798-9	2019	Chenodeoxycholic acid (CDCA) significantly decreased TEER, increased permeability, and increased interleukin-8 (IL-8) release from Caco-2 cells.	Chenodeoxycholic Acid	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	97-110
30844798-9	2019	Chenodeoxycholic acid (CDCA) significantly decreased TEER, increased permeability, and increased interleukin-8 (IL-8) release from Caco-2 cells.	Chenodeoxycholic Acid	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
30844798-9	2019	Chenodeoxycholic acid (CDCA) significantly decreased TEER, increased permeability, and increased interleukin-8 (IL-8) release from Caco-2 cells.	Chenodeoxycholic Acid	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	97-110
30844798-9	2019	Chenodeoxycholic acid (CDCA) significantly decreased TEER, increased permeability, and increased interleukin-8 (IL-8) release from Caco-2 cells.	Chenodeoxycholic Acid	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
30844798-10	2019	Pre-incubation with guggulsterone blocked CDCA-mediated IL-8 release; however, the decrease in TEER was not reversed.	pregna-4,17-diene-3,16-dione	20-33	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
30844798-10	2019	Pre-incubation with guggulsterone blocked CDCA-mediated IL-8 release; however, the decrease in TEER was not reversed.	Chenodeoxycholic Acid	42-46	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
30844798-11	2019	CDCA-induced IL-6 and IL-8 mRNA levels were blocked by guggulsterone.	Chenodeoxycholic Acid	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
30844798-11	2019	CDCA-induced IL-6 and IL-8 mRNA levels were blocked by guggulsterone.	pregna-4,17-diene-3,16-dione	55-68	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
30259626-7	2019	Studies with cell cultures of osteoblasts revealed in response to sodium fluoride (NaF) treatment, there was an induction of p16 hypermethylation and decreased expression, leading to increased cell proliferation, a longer S-phase of the cell cycle, and development of skeletal fluorosis.	Sodium Fluoride	66-81	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
30259626-8	2019	Further, the methylation inhibitor, 5-aza-2-deoxycytidine, reversed the p16 hypermethylation and expression in response to NaF.	Decitabine	36-57	C-X-C motif chemokine ligand 8	Homo sapiens	123-126
30366059-5	2019	Induction of an inflammatory response was observed after LPS treatment and the addition of RESV led to decreases in expression of the inflammatory mediators, tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1), without cytotoxicity.	Resveratrol	91-95	C-X-C motif chemokine ligand 8	Homo sapiens	199-212
30366059-5	2019	Induction of an inflammatory response was observed after LPS treatment and the addition of RESV led to decreases in expression of the inflammatory mediators, tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1), without cytotoxicity.	Resveratrol	91-95	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
30407866-6	2019	On the contrary, challenge with supraphysiological concentrations (10-25 mM), as might be used therapeutically, of propionate or butyrate in combination with TNFalpha resulted in substantially greater IL-6 and CXCL8 release from HLFs and ASM cells than challenge with TNFalpha alone, demonstrating synergistic effects.	Butyrates	129-137	C-X-C motif chemokine ligand 8	Homo sapiens	210-215
30257245-8	2019	Postradiotherapy treatment with different solutions (CHX, NaF, and EGCG) led to lower fluorescence intensity/mm2 in irradiated teeth than in the control group (distilled water; p < 0.05), as a result of MMP inactivation.	Water	170-175	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
30651831-0	2019	Protective effects of astragaloside IV on IL-8-treated diaphragmatic muscle cells.	astragaloside	22-35	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
30651831-4	2019	Diaphragmatic muscle cells extracted from neonatal rats were treated with a series of AS-IV concentrations (5, 10 or 20 mg/l) and the AKT inhibitor GSK690693 in the presence of interleukin-8 (IL-8).	GSK690693	148-157	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
30651831-8	2019	IL-8 treatment resulted in decreased rates of cell proliferation and increased rates of AKT phosphorylation, cell apoptosis, caspase 3/9 activity, ROS production and proinflammatory factor production.	Reactive Oxygen Species	147-150	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
30651831-9	2019	AS-IV and GSK690693 treatment reversed the effects of IL-8.	GSK690693	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
30777526-15	2019	Serum interleukin 8 levels were significantly higher in patients who received sevoflurane on postoperative days 1 (P = .045) and 7 (P = .037).	Sevoflurane	78-89	C-X-C motif chemokine ligand 8	Homo sapiens	6-19
30777526-18	2019	CONCLUSIONS: Although sevoflurane seemed to produce higher interleukin 8 levels posttransplant, both desflurane and sevoflurane had similar effects on posttransplant kidney function.	Sevoflurane	22-33	C-X-C motif chemokine ligand 8	Homo sapiens	59-72
30957871-8	2019	RESULTS: Blocking of CD44H by anti-CD44H mAb on monocytes decreased the engulfment of TMVs and the secretion of CCL4 and CCL5, but had no effect on CCL2, CCL3 and CXCL8.	cd44h	21-26	C-X-C motif chemokine ligand 8	Homo sapiens	163-168
29929938-1	2019	BACKGROUND &amp; PURPOSE: Recent studies suggested a role of prostaglandin E2 (PGE2) in the expression of the chemokine IL-8 by monocytes.	Adenosine Monophosphate	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
29929938-1	2019	BACKGROUND &amp; PURPOSE: Recent studies suggested a role of prostaglandin E2 (PGE2) in the expression of the chemokine IL-8 by monocytes.	Dinoprostone	61-77	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
29929938-1	2019	BACKGROUND &amp; PURPOSE: Recent studies suggested a role of prostaglandin E2 (PGE2) in the expression of the chemokine IL-8 by monocytes.	Dinoprostone	79-83	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
29929938-4	2019	KEY RESULTS: In monocytic cell lines THP-1, MonoMac and U937 PGE2 had only a marginal impact on IL-8 induction but strongly enhanced TNFalpha-induced IL-8 mRNA and protein synthesis.	Dinoprostone	61-65	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
29929938-4	2019	KEY RESULTS: In monocytic cell lines THP-1, MonoMac and U937 PGE2 had only a marginal impact on IL-8 induction but strongly enhanced TNFalpha-induced IL-8 mRNA and protein synthesis.	Dinoprostone	61-65	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
30843005-1	2019	OBJECTIVE: We aimed to assess the feasibility of quantifying fluorine-18-fluorodexoglucose (18F-FDG) and 18F-sodium fluoride (18F-NaF) uptake in abdominal aorta and examine their association with age and cardiovascular risk factors.	18f-sodium fluoride	105-124	C-X-C motif chemokine ligand 8	Homo sapiens	130-133
29929938-5	2019	Similarly, in PBMC IL-8 mRNA induction was larger by simultaneous stimulation with TNFalpha and PGE2 than by either stimulus alone.	Dinoprostone	96-100	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
29929938-8	2019	In HEK293 cells expressing EP4, but not in wild type HEK293 cells lacking EP4, PGE2 enhanced TNFalpha-induced IL-8 protein and mRNA synthesis.	Dinoprostone	79-83	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
29929938-9	2019	In THP-1 cells, the enhancement of TNFalpha-mediated IL-8 mRNA induction by PGE2 was mimicked by a PKA-activator.	Dinoprostone	76-80	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
29929938-11	2019	PGE2 and TNFalpha synergistically activated transcription factor CREB, induced C/EBPss expression and enhanced the activity of an IL-8 promoter fragment containing -223 bp upstream of the transcription start site.	Dinoprostone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
29929938-12	2019	CONCLUSIONS AND IMPLICATIONS: These findings suggest that a combined stimulation of TNFalpha and PGE2/EP4 signal chains in monocytic cells leads to maximal IL-8 promoter activity, as well as IL-8 mRNA and protein induction, by activating the PKA/CREB/C/EBPss as well as NF-kappaB signal chains.	Dinoprostone	97-101	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
29929938-12	2019	CONCLUSIONS AND IMPLICATIONS: These findings suggest that a combined stimulation of TNFalpha and PGE2/EP4 signal chains in monocytic cells leads to maximal IL-8 promoter activity, as well as IL-8 mRNA and protein induction, by activating the PKA/CREB/C/EBPss as well as NF-kappaB signal chains.	Dinoprostone	97-101	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
29934049-4	2019	Here we demonstrated that in human osteoblastic MG-63, U2-OS and Saos-2 cells, besides VEGF, the other two pro-angiogenic factors IL-6 and IL-8 were also up-regulated by hypoxia and CoCl2 (a mimic of hypoxia).	cobaltous chloride	182-187	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
30466028-6	2019	Moreover, linagliptin suppresses TNF-alpha-induced production of pro-inflammatory and pro-adhesive vascular cytokines including IL-6, IL-8, ICAM-1, and VCAM-1.	Linagliptin	10-21	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
30471617-14	2019	In Mrgprx2 knockdown LAD2 cells, the effect of Quercetin (200 muM) reduced C48/80 induced calcium flux and the release of beta-hexosaminidase, histamine, MCP-1 and IL-8 compared with non-atopic control (NC) transfected LAD2 human mast cells, suggesting that Quercetin anti-pseudo-allergic effect was related to Mrgprx2.	Quercetin	47-56	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
31146075-11	2019	In particular, 0.5 g of tungsten showed a significant rise of IL-6 which could also be found for IL-1beta and IL-8.	Tungsten	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
30630560-10	2019	CONCLUSION: Compared with fentanyl combined anesthesia, the remifentanil combined anesthesia can significantly reduce serum levels of cytokines IL-8, IL-6, CRP, TNF- &amp;alpha; and oxidative stress level, and is, therefore, more secure for patients undergoing laparoscopic surgery for colon cancer.	Remifentanil	60-72	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
31560593-1	2019	Objective(s): The incorporation of Arginine (Arg) in NaF-containing child dentifrice might enhance its remineralizing potential, reducing fluorosis risk with significant anti-caries benefit.	Arginine	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
31560593-1	2019	Objective(s): The incorporation of Arginine (Arg) in NaF-containing child dentifrice might enhance its remineralizing potential, reducing fluorosis risk with significant anti-caries benefit.	Arginine	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
31560593-5	2019	Results: The percentage remineralization of the 2% Arg-NaF and 1100-ppm NaF groups was significantly higher than the 600-ppm NaF group (p<0.001).	Arginine	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
31560593-7	2019	The EFU, Ca/P ratio, PO43- content of the 2% Arg-NaF group were significantly higher than the 600-ppm NaF group (p<0.01); while no significant difference was found between the 2% Arg-NaF and 1100-ppm NaF groups.	Arginine	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
31560593-8	2019	Conclusion: Within the limitations of the present study, incorporation of 2% arginine in 600-ppm NaF child formula dentifrice enhanced the remineralization potential of artificial enamel caries, to a level comparable to 1100-ppm NaF adult formula dentifrice.	Arginine	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	97-100
30266621-9	2019	In vitro adsorption of AMI and Naf to the MD membrane was strong (RRvt,AMI = 4.4%, RRvt,Naf = 1.5%) but unspecific adsorption to cOFM was negligibly small (RRvt,AMI = 98% and RRvt,Naf = 98%).	Amitriptyline	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	88-91
30056444-4	2019	PGN-induced secretion of inflammatory factors TNF-alpha and IL-8 in human SZ95 sebocytes was suppressed after knockdown of AhR and pretreatment with the AhR antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	168-176	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
30056444-5	2019	In addition, the AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) enhanced TNF-alpha and IL-8 secretion in PGN-pretreated sebocytes.	Polychlorinated Dibenzodioxins	29-64	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
30056444-5	2019	In addition, the AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) enhanced TNF-alpha and IL-8 secretion in PGN-pretreated sebocytes.	Polychlorinated Dibenzodioxins	66-70	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
30266621-9	2019	In vitro adsorption of AMI and Naf to the MD membrane was strong (RRvt,AMI = 4.4%, RRvt,Naf = 1.5%) but unspecific adsorption to cOFM was negligibly small (RRvt,AMI = 98% and RRvt,Naf = 98%).	Amitriptyline	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	88-91
30507116-8	2018	The benzopyrene directionally led the bronchial epithelium to present observable cell shrinkage, cytoskeleton disintegration, Caspase-3 activation, overproduction of reactive oxygen species, and various inflammatory cytokine (TNF-alpha, IL-6, and IL-8) secretion, suggesting its significant inflammatory and cytotoxic effects on respiratory system.	Benzopyrenes	4-15	C-X-C motif chemokine ligand 8	Homo sapiens	247-251
30584842-9	2019	RESULTS: By FM, NAF-induced FI were higher in CZ than in surrounding skin (P &lt;= 0.001).	carzinophilin	46-48	C-X-C motif chemokine ligand 8	Homo sapiens	16-19
30584842-10	2019	Highest NAF-FI were induced in skin pretreated with a thin CZ (CZ-20 microm), assessed by both FM and FCM and in particular, FI were higher than in skin pretreated with no CZ (CZ-0 microm) (FM P &lt;= 0.041, FCM P &lt; 0.012).	carzinophilin	59-61	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
30584842-10	2019	Highest NAF-FI were induced in skin pretreated with a thin CZ (CZ-20 microm), assessed by both FM and FCM and in particular, FI were higher than in skin pretreated with no CZ (CZ-0 microm) (FM P &lt;= 0.041, FCM P &lt; 0.012).	carzinophilin	63-65	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
30584842-10	2019	Highest NAF-FI were induced in skin pretreated with a thin CZ (CZ-20 microm), assessed by both FM and FCM and in particular, FI were higher than in skin pretreated with no CZ (CZ-0 microm) (FM P &lt;= 0.041, FCM P &lt; 0.012).	Fosfomycin	102-105	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
30584842-10	2019	Highest NAF-FI were induced in skin pretreated with a thin CZ (CZ-20 microm), assessed by both FM and FCM and in particular, FI were higher than in skin pretreated with no CZ (CZ-0 microm) (FM P &lt;= 0.041, FCM P &lt; 0.012).	carzinophilin	63-65	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
30584842-10	2019	Highest NAF-FI were induced in skin pretreated with a thin CZ (CZ-20 microm), assessed by both FM and FCM and in particular, FI were higher than in skin pretreated with no CZ (CZ-0 microm) (FM P &lt;= 0.041, FCM P &lt; 0.012).	carzinophilin	63-65	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
30584842-10	2019	Highest NAF-FI were induced in skin pretreated with a thin CZ (CZ-20 microm), assessed by both FM and FCM and in particular, FI were higher than in skin pretreated with no CZ (CZ-0 microm) (FM P &lt;= 0.041, FCM P &lt; 0.012).	Fosfomycin	208-211	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
30584842-13	2019	NAF-FI were higher than CAF-FI (P &lt;= 0.036), and highest CAF-FI were induced by CZ-0 microm and CZ-20 microm compared to CZ-80 microm (P &lt;= 0.009).	cz-20	99-104	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
30315378-9	2019	Notably, vinpocetine increased TLR3 mRNA levels, as well as protein levels of the downstream signalling molecules TRIF-beta and IRF-3, and serum levels of the anti-inflammatory cytokines IL-10 and IL-8.	vinpocetine	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
31418610-3	2019	Relapsed DME cases (T3) showed significantly higher levels of IL-6 (p = .028), IL-8 (p = .005), IP-10 (p = .013) and MCP-1 (p = .005) compared to T2.Conclusion: IP-10 and MCP-1 AH levels seem to be related to DEX intraocular action, decreasing after injection and increasing when DME relapses.	dme	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
31418610-4	2019	In addition, IL-6 and IL-8 may play a role in DME late evolution and clinical relapse beyond DEX effect.	dme	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
30445053-10	2019	In addition, pretreatment with PPT or DPN increased the expression of IL-8 in activated EoL-1 cells.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
30445053-10	2019	In addition, pretreatment with PPT or DPN increased the expression of IL-8 in activated EoL-1 cells.	diarylpropionitrile	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
30598040-6	2018	DHS diminished interleukin-6 (IL-6) and interleukin-8 (IL-8) secretion but induced the significant upregulation of IL-8 mRNA associated with NF-kappaB and AP-1 activation.	Silybin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
30598040-6	2018	DHS diminished interleukin-6 (IL-6) and interleukin-8 (IL-8) secretion but induced the significant upregulation of IL-8 mRNA associated with NF-kappaB and AP-1 activation.	Silybin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
30598040-6	2018	DHS diminished interleukin-6 (IL-6) and interleukin-8 (IL-8) secretion but induced the significant upregulation of IL-8 mRNA associated with NF-kappaB and AP-1 activation.	Silybin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
30420215-2	2019	Fluorine-18 (18F)-sodium fluoride (NaF) PET similarly portrays osteoblastic activity but with improved spatial and contrast resolution and more accurate anatomic localization.	fluorine-18 (18f)-sodium fluoride	0-33	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
30252571-11	2019	The concentration of IL-8 and IL-10 were decreased in patients with half and standard-dose ticagrelor group.	Ticagrelor	91-101	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
30665751-0	2019	Clinical usefulness of two-phase 18F-sodium-fluoride (18F-NaF) bone PET/CT for evaluating treatment response of bone metastases from breast cancer: Case report.	18f-sodium-fluoride	33-52	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
30665751-1	2019	We report the case of a breast cancer patient in whom a two-phase 18F-sodium-fluoride (18F-NaF) bone PET/CT was useful for detecting hidden bone metastases and assessing treatment response.	18f-sodium-fluoride	66-85	C-X-C motif chemokine ligand 8	Homo sapiens	91-94
30622945-10	2018	Moreover, PL induced an early and transient increase of the pro-inflammatory response triggered by IL-1alpha, by inducing COX-2 expression and secretion of a large amount of PGE2, IL-6, and IL-8.	pl	10-12	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
30582047-1	2018	The separation and recovery of NaF from fluorine containing solution by the common ion effect of Na+ was studied.	Fluorine	40-48	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
30323026-5	2019	Suppression of IL-8 in human embryonic kidney (HEK293) cells that were transformed to express TLR5 was observed not only upon inflammatory stimulation by flagellin but also in response to tumor necrosis factor alpha (TNF-alpha) and phorbol myristate acetate (PMA), despite the fact that the TNF-alpha- and PMA-induced inflammatory pathways reportedly are not TLR5 mediated.	Tetradecanoylphorbol Acetate	232-257	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
30323026-5	2019	Suppression of IL-8 in human embryonic kidney (HEK293) cells that were transformed to express TLR5 was observed not only upon inflammatory stimulation by flagellin but also in response to tumor necrosis factor alpha (TNF-alpha) and phorbol myristate acetate (PMA), despite the fact that the TNF-alpha- and PMA-induced inflammatory pathways reportedly are not TLR5 mediated.	Tetradecanoylphorbol Acetate	259-262	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
30323026-5	2019	Suppression of IL-8 in human embryonic kidney (HEK293) cells that were transformed to express TLR5 was observed not only upon inflammatory stimulation by flagellin but also in response to tumor necrosis factor alpha (TNF-alpha) and phorbol myristate acetate (PMA), despite the fact that the TNF-alpha- and PMA-induced inflammatory pathways reportedly are not TLR5 mediated.	Tetradecanoylphorbol Acetate	306-309	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
30582047-3	2018	It was found that when the compound containing sodium, such as Na2CO3 or Na2SO4 was added into NaF saturated solution to product the common ion effect of Na+, most of the NaF can be crystallized without evaporating concentration, and the added Na2CO3 or Na2SO4 can be recovered by cooling crystallization.	sodium carbonate	63-69	C-X-C motif chemokine ligand 8	Homo sapiens	171-174
30582047-3	2018	It was found that when the compound containing sodium, such as Na2CO3 or Na2SO4 was added into NaF saturated solution to product the common ion effect of Na+, most of the NaF can be crystallized without evaporating concentration, and the added Na2CO3 or Na2SO4 can be recovered by cooling crystallization.	sodium sulfate	73-79	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
30582047-3	2018	It was found that when the compound containing sodium, such as Na2CO3 or Na2SO4 was added into NaF saturated solution to product the common ion effect of Na+, most of the NaF can be crystallized without evaporating concentration, and the added Na2CO3 or Na2SO4 can be recovered by cooling crystallization.	sodium sulfate	73-79	C-X-C motif chemokine ligand 8	Homo sapiens	171-174
30582047-3	2018	It was found that when the compound containing sodium, such as Na2CO3 or Na2SO4 was added into NaF saturated solution to product the common ion effect of Na+, most of the NaF can be crystallized without evaporating concentration, and the added Na2CO3 or Na2SO4 can be recovered by cooling crystallization.	sodium carbonate	244-250	C-X-C motif chemokine ligand 8	Homo sapiens	171-174
30582047-3	2018	It was found that when the compound containing sodium, such as Na2CO3 or Na2SO4 was added into NaF saturated solution to product the common ion effect of Na+, most of the NaF can be crystallized without evaporating concentration, and the added Na2CO3 or Na2SO4 can be recovered by cooling crystallization.	sodium sulfate	254-260	C-X-C motif chemokine ligand 8	Homo sapiens	171-174
30582047-4	2018	Combining cooling crystallization with the common ion effect of Na+, different processes can be designed to recover NaF from different fluorine containing solutions.	Fluorine	135-143	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
30582047-2	2018	The solubility of NaF in the solutions of NaCl, NaNO3, Na2CO3, Na2SO4 and NaOH at 30  C was determined.	Sodium Chloride	42-46	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
30582047-2	2018	The solubility of NaF in the solutions of NaCl, NaNO3, Na2CO3, Na2SO4 and NaOH at 30  C was determined.	sodium nitrate	48-53	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
30582047-2	2018	The solubility of NaF in the solutions of NaCl, NaNO3, Na2CO3, Na2SO4 and NaOH at 30  C was determined.	sodium carbonate	55-61	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
30582047-2	2018	The solubility of NaF in the solutions of NaCl, NaNO3, Na2CO3, Na2SO4 and NaOH at 30  C was determined.	sodium sulfate	63-69	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
30582047-2	2018	The solubility of NaF in the solutions of NaCl, NaNO3, Na2CO3, Na2SO4 and NaOH at 30  C was determined.	Sodium Hydroxide	74-78	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
30582047-3	2018	It was found that when the compound containing sodium, such as Na2CO3 or Na2SO4 was added into NaF saturated solution to product the common ion effect of Na+, most of the NaF can be crystallized without evaporating concentration, and the added Na2CO3 or Na2SO4 can be recovered by cooling crystallization.	Sodium	47-53	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
30582047-3	2018	It was found that when the compound containing sodium, such as Na2CO3 or Na2SO4 was added into NaF saturated solution to product the common ion effect of Na+, most of the NaF can be crystallized without evaporating concentration, and the added Na2CO3 or Na2SO4 can be recovered by cooling crystallization.	Sodium	47-53	C-X-C motif chemokine ligand 8	Homo sapiens	171-174
30582047-3	2018	It was found that when the compound containing sodium, such as Na2CO3 or Na2SO4 was added into NaF saturated solution to product the common ion effect of Na+, most of the NaF can be crystallized without evaporating concentration, and the added Na2CO3 or Na2SO4 can be recovered by cooling crystallization.	sodium carbonate	63-69	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
30273544-11	2018	Collectively, our data showed that HDAC6 mediated upregulation of IL-8 can regulate the Dox sensitivity of OS cells via transcriptionally regulating the expression of ABCB1.	Doxorubicin	88-91	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
30547786-15	2018	TNFalpha treatment elicited strong induction of the chemokine CXCL8, the kinases MAP3K8, MAP4K4 and negative regulators of cytokine signaling, i.e. SOCS2&amp;SOCS3.	Adenosine Monophosphate	154-157	C-X-C motif chemokine ligand 8	Homo sapiens	62-67
30651923-8	2018	Dynamic upward variations were also observed with respect to IL-8 levels in sunitinib-refractory individuals: 28.5 pg/mL at baseline vs. 38.3 pg/mL at 3 months, p-value=0.024.	Sunitinib	76-85	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
31458330-6	2018	It is deduced that the new phases of AlNi, NaF, and KH that were formed in situ during the dehydrogenation process are the key factors for the improvement of dehydrogenation properties of NaAlH4.	sodium aluminum hydride	188-194	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
30273544-0	2018	Histone deacetylase 6 regulated expression of IL-8 is involved in the doxorubicin (Dox) resistance of osteosarcoma cells via modulating ABCB1 transcription.	Doxorubicin	70-81	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
30273544-12	2018	Targeted inhibition of IL-8 might be a potent potential approach for overcome the Dox resistance of OS cells and helpful for clinical therapy of OS patients.	Doxorubicin	82-85	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
30273544-0	2018	Histone deacetylase 6 regulated expression of IL-8 is involved in the doxorubicin (Dox) resistance of osteosarcoma cells via modulating ABCB1 transcription.	Doxorubicin	83-86	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
30273544-3	2018	The expression of IL-8, while not VEGFA, IL-32, or IL-34, was significantly increased in OS/Dox cells as compared with that in the parental cells.	Doxorubicin	92-95	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
30426751-4	2018	Pretreatment of intestinal Caco-2 cells with resveratrol suppressed the TNF-alpha-induced production of IL-8 (control 1.00 +- 0.04, TNFalpha 3.40 +- 0.16, TNFalpha+Res 1.81 +- 0.28 AU, p &lt; 0.05) and phosphorylation of the inflammatory signaling molecules including NF-kappaB, extracellular signal-regulated kinase and stress c-Jun N-terminal protein kinase.	Resveratrol	45-56	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
30178199-3	2018	In this retrospective study, we aimed to assess the uptake of the bone-specific PET radiotracer, F-18 fluoride (NaF), in primary breast cancers to determine its sensitivity and to identify any differences in NaF uptake between calcified and non-calcified tumors, histological subtypes, and patients with or without axillary lymphadenopathy.	f-18 fluoride	97-110	C-X-C motif chemokine ligand 8	Homo sapiens	112-115
30518116-0	2018	Chlorogenic Acid (CGA) Isomers Alleviate Interleukin 8 (IL-8) Production in Caco-2 Cells by Decreasing Phosphorylation of p38 and Increasing Cell Integrity.	Chlorogenic Acid	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	41-54
30518116-0	2018	Chlorogenic Acid (CGA) Isomers Alleviate Interleukin 8 (IL-8) Production in Caco-2 Cells by Decreasing Phosphorylation of p38 and Increasing Cell Integrity.	Chlorogenic Acid	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
30518116-0	2018	Chlorogenic Acid (CGA) Isomers Alleviate Interleukin 8 (IL-8) Production in Caco-2 Cells by Decreasing Phosphorylation of p38 and Increasing Cell Integrity.	Chlorogenic Acid	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	41-54
30518116-0	2018	Chlorogenic Acid (CGA) Isomers Alleviate Interleukin 8 (IL-8) Production in Caco-2 Cells by Decreasing Phosphorylation of p38 and Increasing Cell Integrity.	Chlorogenic Acid	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
30273544-4	2018	IL-8 neutralization antibody can significantly increase the Dox sensitivity of OS/Dox cells.	Doxorubicin	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
30273544-4	2018	IL-8 neutralization antibody can significantly increase the Dox sensitivity of OS/Dox cells.	Doxorubicin	82-85	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
30563042-4	2018	H2O2 at low concentrations can trigger a transient anti-inflammatory adiponectin secretion and reduced gene expression of toll-like receptors (TLRs) in PBMCs but may act as a stimulator of proinflammatory genes (IL6, IL8) and mitochondrial dynamics-related proteins (Mtf2, NRF2, Tfam).	Hydrogen Peroxide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	217-220
30178199-5	2018	F-18 fluoride uptake as maximum standardized uptake value (NaF SUVmax) was measured in the primary tumor, enlarged axillary lymph nodes and contralateral normal/non-tumoral breast tissue.	Fluorides	5-13	C-X-C motif chemokine ligand 8	Homo sapiens	59-62
29457379-8	2018	Subjects with urate deposits had higher IL-6 (257.2 versus 47.0 pg/ml; P = 0.005), IL-8 (73.2 versus 12.0 pg/ml; P = 0.026), and miR-155 (0.21 versus 0.16; P = 0.015) levels than those without deposition findings.	Uric Acid	14-19	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
30372880-10	2018	Furthermore, in vitro studies demonstrated that AJE inhibits TNF-alpha-induced IL-8, IL-1beta, and COX-2 expression in human intestinal epithelial HT-29 cells and tert-butyl hydroperoxide-induced reduction of ZO-1 and occludin expression in human intestinal epithelial Caco-2 cells.	aje	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
29457379-9	2018	CONCLUSION: In individuals with chronic asymptomatic hyperuricemia, the presence of synovitis and double contour sign by US may represent a subclinical manifestation of monosodium urate crystal nucleation, capable of triggering inflammatory pathways (IL-6 and IL-8) and mechanisms of intercellular communication (miR-155), similar to what is observed in patients with gout.	Uric Acid	169-185	C-X-C motif chemokine ligand 8	Homo sapiens	260-264
30372883-6	2018	Vildagliptin potently suppresses high glucose-induced generation of reactive oxygen species (ROS) and production of vascular inflammatory factors including tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), intercellular cell adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein 1 (MCP-1).	Vildagliptin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	197-210
30372883-6	2018	Vildagliptin potently suppresses high glucose-induced generation of reactive oxygen species (ROS) and production of vascular inflammatory factors including tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), intercellular cell adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein 1 (MCP-1).	Vildagliptin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	212-216
30372883-6	2018	Vildagliptin potently suppresses high glucose-induced generation of reactive oxygen species (ROS) and production of vascular inflammatory factors including tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), intercellular cell adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein 1 (MCP-1).	Glucose	38-45	C-X-C motif chemokine ligand 8	Homo sapiens	212-216
30134219-15	2018	Both curcumin-loaded liposomes formulation (1 mug/mL, 5 mug/mL) resulted in significant (p &lt; 0.05) reduction in the level of pro-inflammatory marker expression such as IL-6, IL-8, IL-1beta and TNF-a compared to positive control group.	Curcumin	5-13	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
30325822-5	2018	Although previous publications have reported F-NaF uptake portraying calcification in soft tissue, these findings demonstrate a new domain in which to assess calcium metabolism using F-NaF PET/CT.	Calcium	158-165	C-X-C motif chemokine ligand 8	Homo sapiens	185-188
30276439-0	2018	NaF uptake in unstable plaque: what does fluoride uptake mean?	Fluorides	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
30482611-6	2018	The crystallization reaction was performed by incubating hydroxyapatite powder with NaF or SDF for 48h.	Durapatite	57-71	C-X-C motif chemokine ligand 8	Homo sapiens	84-87
30591798-7	2018	The results from RT-PCR analysis revealed a significant reduction in the expression of genes involved in inflammation including, HMGB1, IL-6 and IL-8 on treatment of DU-145 cells with crocetin.	crocetin	184-192	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
30513776-9	2018	Serum IL-8 level was positively correlated with CC status, weight loss, sarcopenia, but was negatively correlated with total psoas area (TPA).	Tetradecanoylphorbol Acetate	137-140	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
30221352-11	2018	Sr2+ reversed LPS-stimulated proinflammatory cytokine expressions such as tumor necrosis factor alpha, interleukin (IL)-1beta, IL-6 and IL-8.	strontium cation	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
30111198-7	2018	Several studies have shown intriguing pharmacologic effects associated with curcumin, which inhibits NF-kappaB expression by regulating NF-kappaB/IkB pathway and down-regulation expression of pro-inflammatory cytokines, such as Interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha.	Curcumin	76-84	C-X-C motif chemokine ligand 8	Homo sapiens	254-258
30153075-2	2018	Recently, we found that verbascoside, the major component in the sweet olive ethanolic extract (OFE), inhibited IL-8 secretion in human colorectal adenocarcinoma WiDr cells.	acteoside	24-36	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
30153075-5	2018	In the IL-8 secretion assay, both OFE (100 mug/mL) and verbascoside (10 muM) significantly inhibited IL-8 production in WiDr cells.	acteoside	55-67	C-X-C motif chemokine ligand 8	Homo sapiens	7-11
30153075-5	2018	In the IL-8 secretion assay, both OFE (100 mug/mL) and verbascoside (10 muM) significantly inhibited IL-8 production in WiDr cells.	acteoside	55-67	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
30360960-7	2018	AlaGln supplementation also reduced peritoneal protein loss, increased ex vivo stimulated tumor necrosis factor (TNF)-alpha release, and reduced systemic IL-8 levels.	alanylglutamine	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
29941296-8	2018	RESULTS: Those patients who were randomly assigned to risperidone had higher levels of IL-8 (p = 0.000) and MIP-1beta (p = 0.007) than healthy volunteers at baseline, whereas no differences were found between patients initially assigned to aripiprazole and healthy volunteers.	Risperidone	54-65	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
30012425-6	2018	Blocking interaction between hCXCL8 and tsCXCR1/2 with allosteric antagonists (reparixin and SB265610) significantly decreased tree shrew PBMC transmigration.	reparixin	79-88	C-X-C motif chemokine ligand 8	Homo sapiens	29-35
30130557-3	2018	Using Sprague-Dawley rats developmentally exposed to sodium fluoride (NaF) from pregnancy until 6 months of delivery as in vivo model, we showed that fluoride impaired the cognitive abilities of offspring rats, decreased the density of dendritic spines and the expression of synapse proteins synaptophysin (SYN) and postsynaptic density protein-95 (PSD-95) in hippocampus, suggesting fluoride-induced cognitive deficit associates with synaptic impairment.	Sodium Fluoride	53-68	C-X-C motif chemokine ligand 8	Homo sapiens	70-73
30130557-3	2018	Using Sprague-Dawley rats developmentally exposed to sodium fluoride (NaF) from pregnancy until 6 months of delivery as in vivo model, we showed that fluoride impaired the cognitive abilities of offspring rats, decreased the density of dendritic spines and the expression of synapse proteins synaptophysin (SYN) and postsynaptic density protein-95 (PSD-95) in hippocampus, suggesting fluoride-induced cognitive deficit associates with synaptic impairment.	Fluorides	60-68	C-X-C motif chemokine ligand 8	Homo sapiens	70-73
30130557-3	2018	Using Sprague-Dawley rats developmentally exposed to sodium fluoride (NaF) from pregnancy until 6 months of delivery as in vivo model, we showed that fluoride impaired the cognitive abilities of offspring rats, decreased the density of dendritic spines and the expression of synapse proteins synaptophysin (SYN) and postsynaptic density protein-95 (PSD-95) in hippocampus, suggesting fluoride-induced cognitive deficit associates with synaptic impairment.	Fluorides	150-158	C-X-C motif chemokine ligand 8	Homo sapiens	70-73
30130557-6	2018	Importantly, fluoride treatment increased phospho-extracellular signal-regulated kinases 1 and 2 (p-ERK1/2) expression, while inhibition of p-ERK1/2 significantly attenuated the effects of NaF, indicating a regulating role of p-ERK1/2 in BDNF-TrkB signaling disruption.	Fluorides	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	189-192
30012425-6	2018	Blocking interaction between hCXCL8 and tsCXCR1/2 with allosteric antagonists (reparixin and SB265610) significantly decreased tree shrew PBMC transmigration.	1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea	93-101	C-X-C motif chemokine ligand 8	Homo sapiens	29-35
30546347-9	2018	Conclusion: Overall, our findings demonstrated that infertile women with PCOS, who were candidate for IVF benefited from chromium supplementation for 8 weeks in terms of lowering hs-CRP and improving gene expression of PPAR-gamma, GLUT-1, LDLR, and IL-1, though chromium had no effect on the gene expression of IL-8, TNF-alpha, TGF-beta, and VEGF.	Chromium	121-129	C-X-C motif chemokine ligand 8	Homo sapiens	311-315
30485517-10	2018	The production of inflammatory cytokines, including tumor necrosis factor alpha, interleukin (IL)- 6, and IL-8, was reduced by carvacrol in LPS-induced RA-FLSs.	carvacrol	127-136	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
30456862-5	2018	A water-soluble fraction of urban dust (UD-WS) induces pro-inflammatory cytokine release (IL-8) from NHEKs (measured via ELISA).	Water	2-7	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
30456862-5	2018	A water-soluble fraction of urban dust (UD-WS) induces pro-inflammatory cytokine release (IL-8) from NHEKs (measured via ELISA).	ud-ws	40-45	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
30456862-7	2018	RESULTS: In vitro studies using NHEKs demonstrate SIG-1273 protects against urban dust-induced cell toxicity, reducing cell death by 66% and concentration dependently inhibits UD-WS-induced IL-8 production (IC50  = 20 nmol/L), outperforming niacinamide, ascorbic acid, and alpha-tocopherol, commonly used actives in antipollution skin-care products.	ud-ws	176-181	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
30646653-7	2018	Conclusion: Macrophages and IL-8 may play an important role in the pathogenesis of airway inflammation after long-term inhalation of iron and its compounds, the airway function in patients of occupational pulmonary thesaurosis was found damaged.	Iron	133-137	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
30359018-4	2018	Moreover, in the presence of NaF, a ligand exchange was observed by NMR spectroscopy in hafnocene diiodide (Cp2HfI2) to afford hafnocene difluoride (Cp2HfF2).	cp2hff2	149-156	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
30466990-0	2018	Orientin inhibits invasion by suppressing MMP-9 and IL-8 expression via the PKCalpha/ ERK/AP-1/STAT3-mediated signaling pathways in TPA-treated MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	132-135	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
30442959-10	2018	tRF5-AlaCGC activates p65, subsequently leading to enhanced secretion of IL-8 in arsenite response.	arsenite	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
30359018-3	2018	For a catalytic reductive coupling, the addition of sodium fluoride (NaF) to the reaction system is required.	Sodium Fluoride	52-67	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
30359018-4	2018	Moreover, in the presence of NaF, a ligand exchange was observed by NMR spectroscopy in hafnocene diiodide (Cp2HfI2) to afford hafnocene difluoride (Cp2HfF2).	hafnocene diiodide	88-106	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
30359018-4	2018	Moreover, in the presence of NaF, a ligand exchange was observed by NMR spectroscopy in hafnocene diiodide (Cp2HfI2) to afford hafnocene difluoride (Cp2HfF2).	cp2hfi2	108-115	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
30359018-4	2018	Moreover, in the presence of NaF, a ligand exchange was observed by NMR spectroscopy in hafnocene diiodide (Cp2HfI2) to afford hafnocene difluoride (Cp2HfF2).	hafnocene difluoride	127-147	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
30466991-0	2018	Berberine down-regulates IL-8 expression through inhibition of the EGFR/MEK/ERK pathway in triple-negative breast cancer cells.	Berberine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
30466990-9	2018	CONCLUSION: Orientin inhibits migratory and invasive responses by suppressing MMP-9 and IL-8 expression through mitigation of TPA-induced PKCalpha and ERK activation, as well as the nuclear translocation of AP-1 and STAT3.	Tetradecanoylphorbol Acetate	126-129	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
30336048-6	2018	Measurements on micron-sized hematite particles terminated by the charged and amphoteric (012) and the relatively uncharged (001) faces point to the formation of salt loadings of similar composition to those of cryosalts of NaCl, NaBr, NaI, and NaF.	Salts	162-166	C-X-C motif chemokine ligand 8	Homo sapiens	245-248
30466991-2	2018	PURPOSE: Here, we investigated the regulatory mechanism of IL-8 expression as well as the pharmacological effect of berberine (BBR) on IL-8 expression in triple-negative breast cancer (TNBC) cells.	Berberine	116-125	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
30466991-2	2018	PURPOSE: Here, we investigated the regulatory mechanism of IL-8 expression as well as the pharmacological effect of berberine (BBR) on IL-8 expression in triple-negative breast cancer (TNBC) cells.	Berberine	127-130	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
30466991-10	2018	These IL-8 levels were decreased by EGFR (Neratinib and Afatinib) and MEK (PD98059) inhibitors in TNBC cells.	neratinib	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
30466991-10	2018	These IL-8 levels were decreased by EGFR (Neratinib and Afatinib) and MEK (PD98059) inhibitors in TNBC cells.	Afatinib	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
30466991-10	2018	These IL-8 levels were decreased by EGFR (Neratinib and Afatinib) and MEK (PD98059) inhibitors in TNBC cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	75-82	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
30429487-6	2018	In addition, a single intra-discal injection of NTG-101 into the injured IVD-NPs resulted in sustained expression of healthy extra-cellular matrix (ECM) proteins (aggrecan, collagen 2A1) and reduced expression of inflammation associated proteins and molecules (IL-1beta, IL-6, IL-8, MMP-13, Cox-2 and PGE2) as compared to vehicle controls.	ntg-101	48-55	C-X-C motif chemokine ligand 8	Homo sapiens	277-281
30255322-0	2018	Molecular recognition of IL-8, IL-10, IL-12, and IL-15 in biological fluids using phthalocyanine-based stochastic sensors.	phthalocyanine	82-96	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
30400326-4	2018	Exposing monocytes to CaP-CHI-HA resulted in a secretion of pro-healing VEGF and TGF-beta growth factors, TNF-alpha, MCP-1, IL-6 and IL-8 pro-inflammatory mediators but also IL-10 anti-inflammatory cytokine along with an inflammatory index below 1.5 (versus 2.5 and 7.5 following CaP and LPS stimulation, respectively).	cap	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
30295964-4	2018	RESULTS: Poly (I:C) induced the expression of the interferon-stimulated genes (ISG) MxA, OAS2 and APOBEC3G, and the cytokines MCP-1, IL-8, IL-6, CCL20, IFNbeta and RANTES by fibroblasts from all three sites.	Poly I-C	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
30390648-6	2018	RESULTS: Challenge with the omega-6 PUFA arachidonic acid (AA), but not omega-3 PUFAs or SFAs, resulted in increased IL-6 and CXCL8 release from fibroblasts, however IL-6 and CXCL8 release was reduced in COPD (n = 19) compared to non-COPD (n = 36).	omega-6 pufa	28-40	C-X-C motif chemokine ligand 8	Homo sapiens	126-131
30390648-6	2018	RESULTS: Challenge with the omega-6 PUFA arachidonic acid (AA), but not omega-3 PUFAs or SFAs, resulted in increased IL-6 and CXCL8 release from fibroblasts, however IL-6 and CXCL8 release was reduced in COPD (n = 19) compared to non-COPD (n = 36).	omega-6 pufa	28-40	C-X-C motif chemokine ligand 8	Homo sapiens	175-180
30390648-6	2018	RESULTS: Challenge with the omega-6 PUFA arachidonic acid (AA), but not omega-3 PUFAs or SFAs, resulted in increased IL-6 and CXCL8 release from fibroblasts, however IL-6 and CXCL8 release was reduced in COPD (n = 19) compared to non-COPD (n = 36).	Arachidonic Acid	41-57	C-X-C motif chemokine ligand 8	Homo sapiens	126-131
30390648-6	2018	RESULTS: Challenge with the omega-6 PUFA arachidonic acid (AA), but not omega-3 PUFAs or SFAs, resulted in increased IL-6 and CXCL8 release from fibroblasts, however IL-6 and CXCL8 release was reduced in COPD (n = 19) compared to non-COPD (n = 36).	Arachidonic Acid	41-57	C-X-C motif chemokine ligand 8	Homo sapiens	175-180
30175447-10	2018	RESULTS: Excess glucose triggered a trophoblast sterile inflammatory IL-8 and antimigratory response through HMGB1 activation of TLR4.	Glucose	16-23	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
30019285-0	2018	Technical feasibility, radiation dosimetry and clinical use of 18F-sodium fluoride (NaF) in evaluation of metastatic bone disease in pediatric population.	18f-sodium fluoride	63-82	C-X-C motif chemokine ligand 8	Homo sapiens	84-87
30019285-1	2018	PURPOSE: The role of 18F-fluoride (18F-NaF) PET-CT for the detection of bone metastases in adults is well established and is considered superior to conventional bone scintigraphy.	Fluoride ion f-18	21-33	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
30255322-1	2018	Two stochastic sensors based on the modification of graphite paste with the complexes formed by phthalocyanine (PhCN) with Ni and Cu were designed and used for molecular recognition of IL-8, IL-10, IL-12, and IL-15.	Graphite	52-60	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
30255322-1	2018	Two stochastic sensors based on the modification of graphite paste with the complexes formed by phthalocyanine (PhCN) with Ni and Cu were designed and used for molecular recognition of IL-8, IL-10, IL-12, and IL-15.	phthalocyanine	96-110	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
30255322-1	2018	Two stochastic sensors based on the modification of graphite paste with the complexes formed by phthalocyanine (PhCN) with Ni and Cu were designed and used for molecular recognition of IL-8, IL-10, IL-12, and IL-15.	phthalocyanine	112-116	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
30255322-1	2018	Two stochastic sensors based on the modification of graphite paste with the complexes formed by phthalocyanine (PhCN) with Ni and Cu were designed and used for molecular recognition of IL-8, IL-10, IL-12, and IL-15.	Copper	130-132	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
30175388-6	2018	In THP-1 derived macrophages, AOH (1-20 microM) was found to suppress lipopolysaccharide (LPS)-induced NF-kappaB pathway activation, decrease secretion of the proinflammatory cytokines IL-8, IL-6, TNF-alpha and to induce secretion of the anti-inflammatory IL-10.	alternariol	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
30774881-4	2019	Through an experimental and computational approach using fluorescence polarization, ITC, docking and molecular dynamics simulations we investigate the binding of these functionalized GAG derivatives to ten representative regulatory proteins including IL-8, IL-10, BMP-2, sclerostin, TIMP-3, CXCL-12, TGF-beta, FGF-1, FGF-2, and AT-III, and we establish structure-activity relationships for GAG recognition.	Glycosaminoglycans	183-186	C-X-C motif chemokine ligand 8	Homo sapiens	251-255
30178114-0	2018	Changes in plasma interleukin-8 and tumor necrosis factor-alpha levels during the early treatment period as a predictor of the response to sorafenib in patients with unresectable hepatocellular carcinoma.	Sorafenib	139-148	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
30178114-9	2018	CONCLUSIONS: Changes in plasma interleukin-8 and TNF-alpha levels during the first few days could predict the response to sorafenib therapy in HCC patients.	Sorafenib	122-131	C-X-C motif chemokine ligand 8	Homo sapiens	31-44
30193010-1	2018	In an initial screening, the dichloromethane extract from the leaves of Melodorum fruticosum showed distinct inhibitory effects on the release of interleukin-8 (IL-8) in human neutrophils.	Methylene Chloride	29-44	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
30193010-5	2018	Three constituents, melodamide A, 2",4"-dihydroxy-4,6"-dimethoxychalcone, and 2",6"-dihydroxy-4"-methoxychalcone, showed significant inhibition of IL-8 release (IC50 =6.6, 8.6, and 11.6 mum, respectively) and TNF-alpha production (IC50 =4.5, 13.3, and 6.2 mum, respectively).	melodamide A	20-32	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
30014900-4	2018	Our results demonstrate that PCCVC but not Calbuco ash particles induce cytotoxicity on human conjunctival epithelial cells viewed as a decrease in cell proliferation and the transmembrane mucin MUC1 expression; a pro-inflammatory response mediated by IL-6 and IL-8; and an imbalance of the redox environment leading to protein oxidative damage.	pccvc	29-34	C-X-C motif chemokine ligand 8	Homo sapiens	261-265
30193010-5	2018	Three constituents, melodamide A, 2",4"-dihydroxy-4,6"-dimethoxychalcone, and 2",6"-dihydroxy-4"-methoxychalcone, showed significant inhibition of IL-8 release (IC50 =6.6, 8.6, and 11.6 mum, respectively) and TNF-alpha production (IC50 =4.5, 13.3, and 6.2 mum, respectively).	2",4"-dihydroxy-4,6"-dimethoxychalcone	34-72	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
30193010-5	2018	Three constituents, melodamide A, 2",4"-dihydroxy-4,6"-dimethoxychalcone, and 2",6"-dihydroxy-4"-methoxychalcone, showed significant inhibition of IL-8 release (IC50 =6.6, 8.6, and 11.6 mum, respectively) and TNF-alpha production (IC50 =4.5, 13.3, and 6.2 mum, respectively).	2',6'-dihydroxy-4'-methoxychalcone	78-112	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
30179909-1	2018	F-fluoride (F-NaF) uptake in soft tissue metastases of medullary thyroid carcinoma (MTC) has been reported.	f-fluoride	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	14-17
30133131-8	2018	These results indicate that mLU8C-PU inhibits migratory and invasive responses in MCF-7 breast cancer cells by suppressing MMP-9 and IL-8 expression through mitigating TPA-induced PKCalpha, JNK activation, and the nuclear translocation of AP-1 and NF-kappaB.	mlu8c-pu	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
30133131-8	2018	These results indicate that mLU8C-PU inhibits migratory and invasive responses in MCF-7 breast cancer cells by suppressing MMP-9 and IL-8 expression through mitigating TPA-induced PKCalpha, JNK activation, and the nuclear translocation of AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	168-171	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
30783327-0	2018	Sulfated polysaccharides of seagrass Halophila ovalis suppresses tumor necrosis factor-alpha-induced chemokine interleukin-8 secretion in HT-29 cell line.	Polysaccharides	9-24	C-X-C motif chemokine ligand 8	Homo sapiens	111-124
30171271-1	2018	OBJECTIVES: The aim of this study was to evaluate the 18F-sodium fluoride (18F-NaF) coronary uptake compared to coronary intravascular ultrasound (IVUS) in patients with symptomatic coronary artery disease.	18f-sodium fluoride	54-73	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
30171271-2	2018	BACKGROUND: 18F-NaF PET enables the assessment of vascular osteogenesis by interaction with surface hydroxyapatite, while IVUS enables both identification and quantification of intra-plaque components.	Durapatite	100-114	C-X-C motif chemokine ligand 8	Homo sapiens	16-19
30125599-0	2018	IL-8 analogue CXCL8 (3-72) K11R/G31P, modulates LPS-induced inflammation via AKT1-NF-kbeta and ERK1/2-AP-1 pathways in THP-1 monocytes.	g31p	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
30125599-0	2018	IL-8 analogue CXCL8 (3-72) K11R/G31P, modulates LPS-induced inflammation via AKT1-NF-kbeta and ERK1/2-AP-1 pathways in THP-1 monocytes.	g31p	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	14-19
30125599-2	2018	Its antagonist, CXCL8 (3-72) K11R/G31P (G31P), represses inflammatory reactions via competitive binding to CXC chemokine family, preferentially G protein-couple receptors (GPCRs) CXCR1/2.	g31p	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	16-21
30125599-4	2018	LPS (1 microg/ml) induced elevation of IL-8 was significantly reduced by G31P (20 microg/ml and 30 microg/ml), with relatively increased inhibition of CXCR2 than CXCR1.	g31p	73-77	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
30125599-10	2018	Collectively, the IL-8 analogue, G31P, modulates the inflammatory profile of LPS induced inflammation in THP-1 monocytes via AKT1-NF-kbeta and ERK1/2-AP-1 pathways.	g31p	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
30783327-6	2018	CONCLUSION: Overall, the results presented in this study suggest that purified fraction Ho FrIV of Ho-SP could suppress the TNF-alpha-induced secretion of IL-8 in HT-29 and thus could be used as a promising antioxidant and anti-inflammatory candidate with potential benefits.	spiropyran	99-104	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
30114464-5	2018	r-SP potently induced interleukin (IL)-6 and IL-8 at both mRNA and protein levels in a dose- and time-dependent manner, whereas h-SP and f-SP poorly induced them.	r-sp	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
29964032-5	2018	Vaccination of mice with CAMP factor considerably reduced the growth of P. acnes and production of MIP-2, a murine counterpart of human IL-8.	Cyclic AMP	25-29	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
29964032-8	2018	Incubation of ex vivo acne explants with monoclonal antibodies to CAMP factor markedly attenuated the amounts of IL-8 and IL-1beta.	Cyclic AMP	66-70	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
30276549-11	2018	ELISA analysis showed that aspirin significantly decreased the production of inflammatory cytokines IFN-gamma (p value &lt; 0.05) and IL-8 (p value &lt; 0.001) in PE-DMSCs.	Aspirin	27-34	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
30276549-11	2018	ELISA analysis showed that aspirin significantly decreased the production of inflammatory cytokines IFN-gamma (p value &lt; 0.05) and IL-8 (p value &lt; 0.001) in PE-DMSCs.	dmscs	166-171	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
30114464-6	2018	Of note, the mRNA levels of IL-6 and IL-8 were approximately two-fold higher when cells were stimulated with 3 x 107 CFU/ml of r-SP for 3 h, while the protein levels of IL-6 and IL-8 were approximately five-fold higher after stimulation with 3 x 107 CFU/ml of r-SP for 24 h. Furthermore, r-SP exhibited potent activation of Toll-like receptor 2 compared with h-SP or f-SP.	f-sp	367-371	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
30610810-1	2018	PURPOSE: Acute monocytic leukemia remains a big challenge, and there are a series of non-specific esterases which can be inhibited by sodium fluoride (NaF) in mononuclear cells, providing insights into the leukemia targeted therapy.	Sodium Fluoride	134-149	C-X-C motif chemokine ligand 8	Homo sapiens	151-154
30610810-5	2018	The 3-(4, 5-dimethylthiazol-2-yl)-2), 5-diphenyltetrazolium bromide (MTT) assay was used to detect the antitumor effect of NaF on THP-1 cells in vitro.	thiazolyl blue	4-67	C-X-C motif chemokine ligand 8	Homo sapiens	123-126
30610810-9	2018	After 24hrs of exposure to NaF at greater than 1mmol/L, typical apoptotic changes were observed, accompanied by the alpha-NAE positive reaction and decreased intensity.	alpha-nae	116-125	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
30610810-13	2018	CONCLUSION: NaF inhibited the proliferation of THP-1 cells and the activation of alpha-NAE by adversely regulating the expression of Bax and Bcl-2.	alpha-nae	81-90	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
31099333-6	2018	Quantitative results of RT-PCR demonstrated that magnesium supplementation downregulated gene expression levels of interleukin-8 (IL-8) (P = 0.03) and tumor necrosis factor-alpha (TNF-alpha) (P = 0.006) and upregulated gene expression levels of transforming growth factor beta (TGF-beta) (P = 0.03) in PBMCs of women with GDM, compared with placebo.	Magnesium	49-58	C-X-C motif chemokine ligand 8	Homo sapiens	115-128
31099333-6	2018	Quantitative results of RT-PCR demonstrated that magnesium supplementation downregulated gene expression levels of interleukin-8 (IL-8) (P = 0.03) and tumor necrosis factor-alpha (TNF-alpha) (P = 0.006) and upregulated gene expression levels of transforming growth factor beta (TGF-beta) (P = 0.03) in PBMCs of women with GDM, compared with placebo.	Magnesium	49-58	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
31099333-9	2018	Overall, magnesium supplementation for six weeks significantly decreased gene expression levels of IL-8 and TNF-alpha, and increased TGF-beta in women with GDM.	Magnesium	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
30114464-7	2018	The expression of IL-6 and IL-8 induced by r-SP was mediated through the activation of mitogen-activated protein kinases.	r-sp	43-47	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
30114464-9	2018	Taken together, we suggest that r-SP stimulates the human respiratory epithelial cells to produce the cytokines IL-6 and IL-8, which might influence the induction of adaptive immune responses.	r-sp	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
30114464-6	2018	Of note, the mRNA levels of IL-6 and IL-8 were approximately two-fold higher when cells were stimulated with 3 x 107 CFU/ml of r-SP for 3 h, while the protein levels of IL-6 and IL-8 were approximately five-fold higher after stimulation with 3 x 107 CFU/ml of r-SP for 24 h. Furthermore, r-SP exhibited potent activation of Toll-like receptor 2 compared with h-SP or f-SP.	r-sp	127-131	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
30114464-6	2018	Of note, the mRNA levels of IL-6 and IL-8 were approximately two-fold higher when cells were stimulated with 3 x 107 CFU/ml of r-SP for 3 h, while the protein levels of IL-6 and IL-8 were approximately five-fold higher after stimulation with 3 x 107 CFU/ml of r-SP for 24 h. Furthermore, r-SP exhibited potent activation of Toll-like receptor 2 compared with h-SP or f-SP.	r-sp	127-131	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
30114464-6	2018	Of note, the mRNA levels of IL-6 and IL-8 were approximately two-fold higher when cells were stimulated with 3 x 107 CFU/ml of r-SP for 3 h, while the protein levels of IL-6 and IL-8 were approximately five-fold higher after stimulation with 3 x 107 CFU/ml of r-SP for 24 h. Furthermore, r-SP exhibited potent activation of Toll-like receptor 2 compared with h-SP or f-SP.	r-sp	260-264	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
30114464-6	2018	Of note, the mRNA levels of IL-6 and IL-8 were approximately two-fold higher when cells were stimulated with 3 x 107 CFU/ml of r-SP for 3 h, while the protein levels of IL-6 and IL-8 were approximately five-fold higher after stimulation with 3 x 107 CFU/ml of r-SP for 24 h. Furthermore, r-SP exhibited potent activation of Toll-like receptor 2 compared with h-SP or f-SP.	r-sp	260-264	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
30114464-6	2018	Of note, the mRNA levels of IL-6 and IL-8 were approximately two-fold higher when cells were stimulated with 3 x 107 CFU/ml of r-SP for 3 h, while the protein levels of IL-6 and IL-8 were approximately five-fold higher after stimulation with 3 x 107 CFU/ml of r-SP for 24 h. Furthermore, r-SP exhibited potent activation of Toll-like receptor 2 compared with h-SP or f-SP.	h-sp	359-363	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
30373224-3	2018	It was found that only NaF + HCl solution was effective for synthesizing highly pure V2C MXene.	v2c mxene	85-94	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
30630805-1	2018	Present investigation is conducted to investigate the clinical efficacy of mesalazine in combination with the Bifid Triple Viable Capsules on the ulcerative colitis (UC) and the resultant effect on the inflammatory factors (TNF-alpha, IL-8 and IL-10) of UC patients.	Mesalamine	75-85	C-X-C motif chemokine ligand 8	Homo sapiens	235-239
30322479-5	2018	This review highlights the use of 18F-sodium fluoride (NaF) with PET (NaF-PET), NaF-PET/CT, or NaF-PET/MRI in the evaluation of osteoporosis and osteopenia in the lumbar spine and hip.	18f-sodium fluoride	34-53	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
30384436-4	2018	Here, using backbone 15N-relaxation nuclear magnetic resonance (NMR) data, we characterized the dynamic properties of the CXCL8 monomer and the CXCR1 N-domain in the free and bound states.	15n	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	122-127
30261438-6	2018	Polarized T84 monolayers responded to apically applied C3a with increased CXCL8 mRNA more rapidly than if the C3a was applied basolaterally.	T84	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	74-79
30376894-8	2018	The mAb from clone KH4-8 effectively inhibited increases in interleukin-6 (IL-6) and IL-8 expression in recombinant adiponectin-stimulated human osteoblasts and human umbilical vein endothelial cells.	kh4-8	19-24	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
30230320-0	2018	Distinct Differences in Structural States of Conserved Histidines in Two Related Proteins: NMR Studies of the Chemokines CXCL1 and CXCL8 in the Free Form and Macromolecular Complexes.	Histidine	55-65	C-X-C motif chemokine ligand 8	Homo sapiens	131-136
30259744-9	2018	diCQA isomers were relatively more effective at reducing IL-8 ( p &lt; 0.05).	dicqa	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
30405600-8	2018	Intestinal crypts cultured with supernatants from BI119-treated commensal-specific CD4+ T cells showed decreased expression of CXCL1, CXCL8 and CCL20.	bi119	50-55	C-X-C motif chemokine ligand 8	Homo sapiens	134-139
30405600-10	2018	BI119 has a more profound effect in ileal CD with additional significant downregulation of IL23R, CSF2, CXCL1, CXCL8, and S100A8, and upregulation of DEFA5.	bi119	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	111-116
30230320-3	2018	Here, we characterized the structural features of histidines in the chemokines CXCL8 and CXCL1 in the free, GAG heparin-bound, and CXCR2 receptor N-terminal domain-bound states using solution NMR spectroscopy.	Histidine	50-60	C-X-C motif chemokine ligand 8	Homo sapiens	79-84
30230320-3	2018	Here, we characterized the structural features of histidines in the chemokines CXCL8 and CXCL1 in the free, GAG heparin-bound, and CXCR2 receptor N-terminal domain-bound states using solution NMR spectroscopy.	gag heparin	108-119	C-X-C motif chemokine ligand 8	Homo sapiens	79-84
30230320-4	2018	CXCL8 and CXCL1 share two conserved histidines, one in the N-loop and the other in the 30s loop.	Histidine	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
30546959-7	2019	Mechanistically, MALAT1 recruited Brahma-related gene 1 (BRG1), a catalytic subunit of chromatin remodeling complex switching/sucrose non-fermentable (SWI/SNF), to the promoter region of IL-6 and CXCL8, and thus facilitated NF-kappaB to induce the expression of these inflammatory factors.	Sucrose	126-133	C-X-C motif chemokine ligand 8	Homo sapiens	196-201
30230320-5	2018	In CXCL8, both histidines exist in the Nepsilon2 tautomeric state in the free, GAG-bound, and receptor-bound forms.	Histidine	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	3-8
30230320-5	2018	In CXCL8, both histidines exist in the Nepsilon2 tautomeric state in the free, GAG-bound, and receptor-bound forms.	Glycosaminoglycans	79-82	C-X-C motif chemokine ligand 8	Homo sapiens	3-8
30314357-3	2018	At IC50, 2-AmPh caused decrease in nuclear content of NF-kappaB p65 polypeptide and mRNA expression of NF-kappaB target genes encoding interleukin-8 and anti-apoptotic protein BIRC3.	2-amph	9-15	C-X-C motif chemokine ligand 8	Homo sapiens	135-148
30014946-0	2018	A highly selective electrochemical immunosensor based on conductive carbon black and star PGMA polymer composite material for IL-8 biomarker detection in human serum and saliva.	Polymers	95-102	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
30014946-2	2018	In this study, we developed an electrochemical IL 8 biosensor by modification with a conductive composite including Super P, polyvinylidene fluoride (PVDF) and star polymer (SPGMA) of disposable ITO electrode surface.	polyvinylidene fluoride	125-148	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
30014946-2	2018	In this study, we developed an electrochemical IL 8 biosensor by modification with a conductive composite including Super P, polyvinylidene fluoride (PVDF) and star polymer (SPGMA) of disposable ITO electrode surface.	polyvinylidene fluoride	150-154	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
30014946-4	2018	Anti-IL 8 antibodies were utilized as biorecognition molecules and bound to epoxy groups of star polymer covalently.	star polymer	92-104	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
30014946-9	2018	Super P-star polymer composite modified immunosensor was easy, sensitive, cheap and reliable analytical method for IL 8 detection.	Polymers	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
30402038-7	2018	Lonafarnib significantly suppressed LPS-, IL-1beta-, or TNF-alpha-induced IL-6, IL-8, MCP-1, and GRO-alpha expression and secretion in placental tissue.	lonafarnib	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
30333797-9	2018	CPA patients did not differ significantly in the BALF cytokine profile compared to patients with respiratory disorders without CPA, but showed significant higher values for IFN-gamma, IL-1b, IL-6, IL-8, and TNF-alpha compared to healthy individuals.	cpa	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
30199234-10	2018	After addition of TNF-alpha to the monolayer, two compounds (butyrate and gallic acid) suppressed IL-8 production, suggesting their potential anti-inflammatory effects, whereas the dietary factor forskolin significantly increased IL-8 production.	Gallic Acid	74-85	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
30199234-10	2018	After addition of TNF-alpha to the monolayer, two compounds (butyrate and gallic acid) suppressed IL-8 production, suggesting their potential anti-inflammatory effects, whereas the dietary factor forskolin significantly increased IL-8 production.	Colforsin	196-205	C-X-C motif chemokine ligand 8	Homo sapiens	230-234
30199234-10	2018	After addition of TNF-alpha to the monolayer, two compounds (butyrate and gallic acid) suppressed IL-8 production, suggesting their potential anti-inflammatory effects, whereas the dietary factor forskolin significantly increased IL-8 production.	Butyrates	61-69	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
30194878-9	2018	RESULTS: Compared to excess glucose alone, combination excess glucose and low-dose aPL (a) further augmented trophoblast inflammatory IL-1beta, inflammasome-associated uric acid and caspase-1, and pro-angiogenic PlGF; (b) dampened trophoblast inflammatory IL-8, anti-angiogenic sEndoglin, and sFlt-1; and (c) further reduced trophoblast migration.	Glucose	62-69	C-X-C motif chemokine ligand 8	Homo sapiens	256-260
30390734-37	2018	Nicotinamide can inhibit cytokine release (IL-1, IL-6, IL-8, and TNF-alpha) from immune cells, inhibit chemotaxis and degranulation of immune cells, inhibit lymphocyte blast transformation, and suppress T-cell activity (6).	Niacinamide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
29435831-2	2018	With the exception of the control group, human umbilical vein endothelial cells (HUVECs) were treated with sodium fluoride (NaF) (1.2 mug/mL) for 24 h, with or without a 2-h pretreatment with 100 nM insulin-like growth factor 1 (IGF-1, a PI3K/AKT agonist), or 10 muM histamine (HIS, a eNOS agonist).	Sodium Fluoride	107-122	C-X-C motif chemokine ligand 8	Homo sapiens	124-127
29800615-9	2018	Levels of inflammatory cytokines IL-8, IL-10, IL-6, TNFR2, INF-alpha, and INF-beta were reduced after ruxolitinib treatment.	ruxolitinib	102-113	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
30022772-0	2018	TRPV4 Channel-Regulated ATP Release Contributes to gamma-Irradiation-Induced Production of IL-6 and IL-8 in Epidermal Keratinocytes.	Adenosine Triphosphate	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
30022772-5	2018	HaCaT cells treated with TRPV4 channel agonist GSK1016790A also showed increased IL-6 and IL-8 production.	N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide	47-58	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
30022772-6	2018	In both cases, IL-6/IL-8 production was not increased at 24 h after stimulation, but was increased at 48 h. ATP was released from cells exposed to gamma-irradiation or TRPV4 channel agonist, and the release was suppressed by TRPV4 channel inhibitors.	Adenosine Triphosphate	108-111	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
30022772-7	2018	The gamma-irradiation-induced increase in IL-6 and IL-8 production was suppressed by apyrase (ecto-nucleotidase), NF157 (selective P2Y11 receptor antagonist) and SB203580 (p38 MAPK inhibitor).	SB 203580	162-170	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
30022772-9	2018	Our results suggest that gamma-irradiation of keratinocytes induces ATP release via activation of the TRPV4 channel, and then ATP activates P2Y11 receptor and p38 MAPK-NF-kappaB signaling, resulting in IL-6/IL-8 production.	Adenosine Triphosphate	126-129	C-X-C motif chemokine ligand 8	Homo sapiens	207-211
30119218-6	2018	The presence of loratadine in endothelial culture efficiently suppressed ox-LDL-induced attachment of monocytes to endothelial cells, production of ROS and vascular adhesion molecules, and induction cytokines including VCAM-1, E-selectin, TNF-alpha, IL-6 and IL-8.	Loratadine	16-26	C-X-C motif chemokine ligand 8	Homo sapiens	259-263
30119221-4	2018	Results showed that treatment with prunetin (10, 30, and 50 muM) inhibited lipopolysaccharide (LPS)-induced expression and secretion of interleukin (IL)-6, IL-8, and mucin 5 AC (MUC5 AC) in RPMI2650 cells, and attenuated the effect of LPS on toll-like receptor 4 (TLR4) and myeloid differentiation primary response 88 (MyD88) expression.	prunetin	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
30119221-5	2018	TAK-242 (an inhibitor of TLR4) treatment or TLR4 knockdown attenuated LPS-induced expression and secretion of IL-6, IL-8 and MUC5 AC.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
29435831-4	2018	The levels of NO significantly decreased in all experimental groups; however, the levels of NO were obviously higher in the NaF + HIS and NaF + IGF-1 groups, compared to the NaF group.	Histamine	130-133	C-X-C motif chemokine ligand 8	Homo sapiens	124-127
29435831-5	2018	The p-eNOS/eNOS ratios dropped clearly in NaF and NaF + HIS groups, while that in the NaF + HIS group was distinctly higher than that in the NaF group.	Histamine	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
29435831-5	2018	The p-eNOS/eNOS ratios dropped clearly in NaF and NaF + HIS groups, while that in the NaF + HIS group was distinctly higher than that in the NaF group.	Histamine	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
29435831-5	2018	The p-eNOS/eNOS ratios dropped clearly in NaF and NaF + HIS groups, while that in the NaF + HIS group was distinctly higher than that in the NaF group.	Histamine	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
30059431-0	2018	Targeted Therapy With Anaplastic Lymphoma Kinase Inhibitor (Alectinib) in Adolescent Metastatic Non-Small Cell Lung Carcinoma: 18F-NaF PET/CT in Response Evaluation.	alectinib	60-69	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
29934223-3	2018	OMVs from both EHEC O157:H7 and sorbitol-fermenting (SF) EHEC O157:H- induced production of interleukin-8 (IL-8) in Caco-2, HCT-8, and HT-29 intestinal epithelial cell lines.	Sorbitol	32-40	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
29951871-5	2018	The results showed that taraxasterol not only reduced the production of TNF-alpha, IL-8, PGE2, and NO induced by LPS, but also reduced the expression of iNOS and COX-2.	taraxasterol	24-36	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
29951871-8	2018	The inhibition of taraxasterol on TNF-alpha, IL-8, PGE2, and NO production can be reversed by geranylgeranyl diphosphate (GGPP, the LXRalpha inhibitor).	taraxasterol	18-30	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
29951871-8	2018	The inhibition of taraxasterol on TNF-alpha, IL-8, PGE2, and NO production can be reversed by geranylgeranyl diphosphate (GGPP, the LXRalpha inhibitor).	geranylgeranyl pyrophosphate	94-120	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
29951871-8	2018	The inhibition of taraxasterol on TNF-alpha, IL-8, PGE2, and NO production can be reversed by geranylgeranyl diphosphate (GGPP, the LXRalpha inhibitor).	geranylgeranyl pyrophosphate	122-126	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
29983334-5	2018	Here, we show that primary human monocytes stimulated with Shiga toxin 1a (Stx1a) through the glycolipid receptor globotriaosylceramide released larger amounts of proinflammatory molecules (IL-1beta, TNFalpha, IL-6, G-CSF, CXCL8, CCL2, CCL4) than Stx1a-treated neutrophils.	globotriaosylceramide	114-135	C-X-C motif chemokine ligand 8	Homo sapiens	223-228
30015917-8	2018	Overall, the present results suggested that wogonin inhibited the 5-LO/BLT2/ERK/IL-8/MMP-9 signaling cascade and demonstrated that this cascade may be an important target through which wogonin exerts its anticancer effects in breast cancer.	wogonin	44-51	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
30102465-7	2018	PA, but not OA, enhances the production of IL-6 and IL-8 in response to TNF-alpha.	Palmitic Acid	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
28852897-1	2018	PURPOSE: In this study, we elucidated the effects of berberine, a major alkaloid component contained in medicinal herbs, such as Phellodendri Cortex and Coptidis Rhizoma, on expression of monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8) in a human retinal pigment epithelial cell line (ARPE-19) caused by lipopolysaccharide (LPS) stimulation.	Berberine	53-62	C-X-C motif chemokine ligand 8	Homo sapiens	231-244
28852897-1	2018	PURPOSE: In this study, we elucidated the effects of berberine, a major alkaloid component contained in medicinal herbs, such as Phellodendri Cortex and Coptidis Rhizoma, on expression of monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8) in a human retinal pigment epithelial cell line (ARPE-19) caused by lipopolysaccharide (LPS) stimulation.	Berberine	53-62	C-X-C motif chemokine ligand 8	Homo sapiens	246-250
28852897-7	2018	CONCLUSIONS: These findings indicate that berberine inhibited the expression of MCP-1 and IL-8 induced by LPS.	Berberine	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
29030990-6	2018	Moreover, nanohydrogel of quercetin was able to reduce significantly IL-8, IL-6, and VEGF production in pro-inflammatory conditions with interesting implications on the mechanism of glioblastoma cells drug resistance.	Quercetin	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
30203575-7	2018	RESULTS: In the substance P-induced inflammation model, 2% diosmin cream exhibited significant vasoconstrictive (proportion of dilated capillaries: -29%, capillary luminal area: -49% vs no cream + stress) and anti-inflammatory (IL-8 release: -36% vs no cream + stress) effects.	Diosmin	59-66	C-X-C motif chemokine ligand 8	Homo sapiens	228-232
28176254-2	2018	18Fluorine-labeled sodium fluoride (18F-NaF) is a widely available radioisotope and PET imaging allows for absolute quantification of tracer uptake.	Fluorine-18	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
28176254-2	2018	18Fluorine-labeled sodium fluoride (18F-NaF) is a widely available radioisotope and PET imaging allows for absolute quantification of tracer uptake.	Sodium Fluoride	19-34	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
30100024-14	2018	RESULTS: Simvastatin reduced TLR4-induced ICAM-1, IL-8, and MCP-1 expression in AVICs.	Simvastatin	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
29992525-6	2018	In particular, 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) has shown promise in the detection of both high-risk atherosclerotic plaque features and vascular calcification activity, which predicts future development of new vascular calcium deposits.	18f-sodium fluoride	15-34	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
29992525-6	2018	In particular, 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) has shown promise in the detection of both high-risk atherosclerotic plaque features and vascular calcification activity, which predicts future development of new vascular calcium deposits.	Calcium	252-259	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
29882686-10	2018	ZnO and CuO nanoparticles displayed severe cytotoxicity and enhanced gene expression of heme oxygenase-1 (HO-1) and interleukin-8 (IL-8).	Zinc Oxide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	116-129
30217257-8	2018	RESULTS: Honokiol significantly decreased pro-inflammatory cytokine (IL1A, IL6) and chemokine (CXCL8, CXCL1, CCL2) mRNA expression and secretion from fetal membranes (amnion and choriodecidua) and myometrium stimulated with LPS, fsl-1 or poly(I:C).	honokiol	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	95-100
30217943-9	2018	The levels of TNF-alpha, IL-8, CC16, and ICAM-1 in EBC were significantly lower, and SOD activity was higher, at T2 in the NAC group; similar data were found in serum at T2, T3, and T4.	Acetylcysteine	123-126	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
30033171-1	2018	The aim of this work was to investigate the complex phenomena underlying the adsorption of an anti-human IL-8 (anti-IL8) monoclonal antibody (mAb) to m-aminophenylboronate (m-APBA) by Flow Microcalorimetry (FMC) and to understand the role of non-specific interactions in the adsorption process.	m-aminophenylboronate	150-171	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
30033171-1	2018	The aim of this work was to investigate the complex phenomena underlying the adsorption of an anti-human IL-8 (anti-IL8) monoclonal antibody (mAb) to m-aminophenylboronate (m-APBA) by Flow Microcalorimetry (FMC) and to understand the role of non-specific interactions in the adsorption process.	m-aminophenylboronate	150-171	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
30033171-1	2018	The aim of this work was to investigate the complex phenomena underlying the adsorption of an anti-human IL-8 (anti-IL8) monoclonal antibody (mAb) to m-aminophenylboronate (m-APBA) by Flow Microcalorimetry (FMC) and to understand the role of non-specific interactions in the adsorption process.	m-apba	173-179	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
30033171-1	2018	The aim of this work was to investigate the complex phenomena underlying the adsorption of an anti-human IL-8 (anti-IL8) monoclonal antibody (mAb) to m-aminophenylboronate (m-APBA) by Flow Microcalorimetry (FMC) and to understand the role of non-specific interactions in the adsorption process.	m-apba	173-179	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
30033171-3	2018	Results showed that the adsorption of anti-IL8 mAb to m-APBA is enthalpically driven (DeltaHads&lt;0), as expected for the predominant reversible esterification reaction between boronates and cis-diols-containing molecules.	deltahads	86-95	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
30033171-3	2018	Results showed that the adsorption of anti-IL8 mAb to m-APBA is enthalpically driven (DeltaHads&lt;0), as expected for the predominant reversible esterification reaction between boronates and cis-diols-containing molecules.	boronates	178-187	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
30033171-3	2018	Results showed that the adsorption of anti-IL8 mAb to m-APBA is enthalpically driven (DeltaHads&lt;0), as expected for the predominant reversible esterification reaction between boronates and cis-diols-containing molecules.	cis-diols	192-201	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
30266096-8	2018	RESULTS: Ingenol mebutat significantly and dose-dependently induced the expression of proinflammatory chemokines (CXCL8, CCL2) and AMP (RNase7, HBD3) in HEK and epithelial cancer cell lines.	ingenol	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	114-119
30261896-11	2018	In the CSF, methylprednisolone enhanced the interleukin-8 release (p &lt; 0.001) but did not affect postoperative changes in CSF levels of tumor necrosis factor alpha.	Methylprednisolone	12-30	C-X-C motif chemokine ligand 8	Homo sapiens	44-57
30086077-1	2018	OBJECTIVE: The aim of this study was to describe osseous metabolic activity with respect to age and weight in the spine as expressed through fluorine-18-sodium fluoride (F-NaF) uptake in a healthy male population.	fluorine-18-sodium fluoride	141-168	C-X-C motif chemokine ligand 8	Homo sapiens	172-175
30219183-1	2018	18F-sodium fluoride (18F-NaF) PET/CT provides high sensitivity and specificity for the assessment of bone and joint diseases.	18f-sodium fluoride	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
30505227-1	2018	The use of F-18 sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) bone scan is increasing because of its higher sensitivity and specificity over standard bone scintigraphy (BS).	Fluorine-18	11-15	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
30505227-1	2018	The use of F-18 sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) bone scan is increasing because of its higher sensitivity and specificity over standard bone scintigraphy (BS).	Sodium Fluoride	16-31	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
30486522-3	2018	The mechanism is mainly by inhibiting the activation of nuclear factor (NF-kappaB), mitogen-activated protein kinase (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways and down-regulating the inflammatory gene expression including tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), nitric oxide (NO), interleukin-1(IL-1), IL-6, IL-8 and other inflammatory factors.	Dinoprostone	310-326	C-X-C motif chemokine ligand 8	Homo sapiens	381-385
30486522-3	2018	The mechanism is mainly by inhibiting the activation of nuclear factor (NF-kappaB), mitogen-activated protein kinase (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways and down-regulating the inflammatory gene expression including tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), nitric oxide (NO), interleukin-1(IL-1), IL-6, IL-8 and other inflammatory factors.	Dinoprostone	328-332	C-X-C motif chemokine ligand 8	Homo sapiens	381-385
30486522-3	2018	The mechanism is mainly by inhibiting the activation of nuclear factor (NF-kappaB), mitogen-activated protein kinase (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways and down-regulating the inflammatory gene expression including tumor necrosis factor-alpha (TNF-alpha), prostaglandin E2 (PGE2), nitric oxide (NO), interleukin-1(IL-1), IL-6, IL-8 and other inflammatory factors.	Nitric Oxide	335-347	C-X-C motif chemokine ligand 8	Homo sapiens	381-385
29882686-10	2018	ZnO and CuO nanoparticles displayed severe cytotoxicity and enhanced gene expression of heme oxygenase-1 (HO-1) and interleukin-8 (IL-8).	Zinc Oxide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
29882686-11	2018	The IL-8 gene expression was also increased from Bi2O3 exposure.	bi2o3	49-54	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
29882686-14	2018	The enhancement of HO-1, IL-8, and MT2A gene expressions was related to the cytotoxic activity of metal oxide nanoparticles.	metal oxide	98-109	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
30236152-8	2018	In contrast, DEX was the strongest inhibitor of IL-6, IL-8, and tissue-destructive enzymes in RASF.	Dexamethasone	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
30236078-2	2018	The purpose of this study is to assess the role of 18F-Sodium fluoride (18F-NaF) positron emission tomography-computed tomography (PET/CT) bone scans in evaluating patients with limited ankle range of motion (ROM) after trauma.	18f-sodium fluoride	51-70	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
29402343-10	2018	The increased phosphorylations of PI3K, AKT, and mTOR, and the upregulation of CXCL8 induced by miR-204 suppression were all abolished by the addition of LY294002 and AZD8055 (inhibitors of PI3K/AKT and mTOR, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	C-X-C motif chemokine ligand 8	Homo sapiens	79-84
30188700-0	2018	Cell Motility Facilitated by Mono(2-ethylhexyl) Phthalate via Activation of the AKT-beta-Catenin-IL-8 Axis in Colorectal Cancer.	mono-(2-ethylhexyl)phthalate	29-57	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
30188700-6	2018	Our results showed that treatment with MEHP enriched the population of cancer-stem-cell (CSC)-like cells and upregulated IL-8 expression by inducing the AKT-beta-catenin-TCF4 signaling pathway.	mono-(2-ethylhexyl)phthalate	39-43	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
30188700-7	2018	Blocking beta-catenin-TCF4-mediated IL-8 expression reversed the MEHP-induced migration and enrichment of CSC-like cells.	mono-(2-ethylhexyl)phthalate	65-69	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
29402343-10	2018	The increased phosphorylations of PI3K, AKT, and mTOR, and the upregulation of CXCL8 induced by miR-204 suppression were all abolished by the addition of LY294002 and AZD8055 (inhibitors of PI3K/AKT and mTOR, respectively).	(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol	167-174	C-X-C motif chemokine ligand 8	Homo sapiens	79-84
30258441-1	2018	The glutamic acid-leucine-arginine (ELR) motif is a hallmark feature shared by mammalian inflammatory CXC chemokines such the granulocyte chemo-attractant CXCL8 (interleukin-8, IL-8).	glutamic acid-leucine-arginine	4-34	C-X-C motif chemokine ligand 8	Homo sapiens	155-160
30223511-2	2018	The aim of this paper was to investigate the influence of Dentin Caries-like Lesions (DCLL)-Producing Model on microtensile bond strength (muTBS) of etch and rinse adhesive systems and investigate the effect of remineralizing agents such as Sodium Fluoride (NaF), MI Paste  (MP) and Curodont  Repair (CR) on caries-affected dentin (n = 6).	dcll	86-90	C-X-C motif chemokine ligand 8	Homo sapiens	258-261
30258441-1	2018	The glutamic acid-leucine-arginine (ELR) motif is a hallmark feature shared by mammalian inflammatory CXC chemokines such the granulocyte chemo-attractant CXCL8 (interleukin-8, IL-8).	glutamic acid-leucine-arginine	4-34	C-X-C motif chemokine ligand 8	Homo sapiens	162-175
30258441-1	2018	The glutamic acid-leucine-arginine (ELR) motif is a hallmark feature shared by mammalian inflammatory CXC chemokines such the granulocyte chemo-attractant CXCL8 (interleukin-8, IL-8).	glutamic acid-leucine-arginine	4-34	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
30258441-1	2018	The glutamic acid-leucine-arginine (ELR) motif is a hallmark feature shared by mammalian inflammatory CXC chemokines such the granulocyte chemo-attractant CXCL8 (interleukin-8, IL-8).	elr	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	155-160
30258441-1	2018	The glutamic acid-leucine-arginine (ELR) motif is a hallmark feature shared by mammalian inflammatory CXC chemokines such the granulocyte chemo-attractant CXCL8 (interleukin-8, IL-8).	elr	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	162-175
30258441-1	2018	The glutamic acid-leucine-arginine (ELR) motif is a hallmark feature shared by mammalian inflammatory CXC chemokines such the granulocyte chemo-attractant CXCL8 (interleukin-8, IL-8).	elr	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
30205620-7	2018	PE concentrations of ENA-78/VEGF/IL-8/MDC/PCS/indoxyl sulphate correlate with serum creatinine concentrations.	Creatinine	84-94	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
30204781-9	2018	CONCLUSIONS: The IL-8 concentration in the aqueous humor was associated with responsiveness to IVB in DME patients.	dme	102-105	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
30254551-8	2018	The sensitivity, specificity, and agreement rate of 18F-NaF PET/CT for detecting bone metastatic lesions were 98.3%, 65.7%, and 92.9%, respectively; these values were 42.9%, 97.1%, and 51.9%, respectively, for 18F-FDG PET/CT.	Fluorine-18	52-55	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
30233225-8	2018	Results: Dextran sulfate strongly and significantly inhibited PMA-induced PGE2 production, inhibited KLK5 and MMP-9 mRNA expression, and IL-8, IL-1alpha and VEGF production, and displayed a highly significant inhibitory effect on VEGF-induced pseudotube formation.	Dextran Sulfate	9-24	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
30233225-9	2018	In SP-stimulated human skin explants, HMC significantly decreased the proportion of dilated vessels, total vessel area, and IL-8 production.	TFF2 protein, human	3-5	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
29758106-9	2018	Among all subjects, sputum H2 S levels showed a trend to decrease with FEV1 %predicted and significantly positive correlations with sputum neutrophils (%), sputum IL-8 and serum IL-8.	Deuterium	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
30193323-9	2018	Treatment with idelalisib inhibited the IL-1beta-induced expression of IL-6 and IL-8.	idelalisib	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
30254686-7	2018	As a result, ALE showed significant antioxidant activities and inhibited the production of reactive oxygen species (ROS), matrix metalloproteinases (MMPs), and interleukin-8 (IL-8) as well as suppressed mitogen-activated proteins kinases (MAPKs) such as extracellular signal regulated kinases (ERK), c-Jun N terminal kinases (JNK), and p38 MAPK triggered by heat shock treatment in human dermal fibroblasts (HDFs).	Epinephrine	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	160-173
30254686-7	2018	As a result, ALE showed significant antioxidant activities and inhibited the production of reactive oxygen species (ROS), matrix metalloproteinases (MMPs), and interleukin-8 (IL-8) as well as suppressed mitogen-activated proteins kinases (MAPKs) such as extracellular signal regulated kinases (ERK), c-Jun N terminal kinases (JNK), and p38 MAPK triggered by heat shock treatment in human dermal fibroblasts (HDFs).	Epinephrine	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
29758106-9	2018	Among all subjects, sputum H2 S levels showed a trend to decrease with FEV1 %predicted and significantly positive correlations with sputum neutrophils (%), sputum IL-8 and serum IL-8.	Deuterium	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
29524267-0	2018	Cytokine patterns in vitro, in particular IL-5/IL-8 ratio, to detect patients with nickel contact allergy.	Nickel	83-89	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
30411727-4	2018	SUBJECTS AND METHODS: This study was part of the cardiovascular molecular calcification assessed by 18F-sodium fluoride (NaF) (CAMONA) PET/computed tomography (CT) study.	Sodium Fluoride	104-119	C-X-C motif chemokine ligand 8	Homo sapiens	121-124
29931171-9	2018	Stimulation of primary trophoblasts with palmitate led to increased mRNA expression and protein release of the cytokine IL6 and the chemokine IL8.	Palmitates	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	142-145
30080191-1	2018	F-sodium fluoride (NaF) is a bone-seeking agent that can also localize extraosseous calcifying lesions.	f-sodium fluoride	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
29990693-8	2018	Furthermore, the levels of inflammatory factors IL-1beta, IFN-gamma and TNF-alpha were decreased after CXCL8-IP10, dexamethasone or ceftazidime treatment.	Ceftazidime	132-143	C-X-C motif chemokine ligand 8	Homo sapiens	103-108
30015877-6	2018	Furthermore, RA inhibited the production of pro-angiogenic factors, including matrix metalloproteinase (MMP)-9, pentraxin-3, interleukin-8, VEGF and placental growth factor under normoxic and hypoxic conditions, and suppressed the phorbol 12-myristate 13-acetate-induced increase in the gelatinolytic MMP-9 activity and MMP-9 expression in HT1080 cells.	rhapontin	13-15	C-X-C motif chemokine ligand 8	Homo sapiens	125-138
30175192-7	2018	Imiquimod-induced expression of interleukin (IL)-6, IL-8, and vascular endothelial growth factor (VEGF) was inhibited by TLR7 siRNA in HIOEC cells as determined by reverse transcription polymerase chain reaction (RT-PCR).	Imiquimod	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
30025786-5	2018	RESULTS: While IP-10 levels were significantly reduced in TB+ subjects in all the sub-groups, IL-8 levels were significantly reduced in NDM-TB+ and increased in KDM-TB+ subjects.	Terbium	140-142	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
30015902-5	2018	Pretreatment with spilanthol decreased TNF-alpha-induced COX-2 expression by western blotting and suppressed the expression of pro-inflammatory mediators, including interleukin (IL)-6, IL-8 and monocyte chemotactic protein 1 using ELISA.	N-isobutyl-2E-decenamide	18-28	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
29761497-9	2018	The indomethacin significantly attenuated the increases of PGE2 , IL-6, and IL-8 expression in cells stimulated with compressive force or mechanical vibration combined with compressive force.	Indomethacin	4-16	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
29761497-10	2018	In addition, exogenous PGE2 increased IL-6 and IL-8 mRNA and protein expressions in hPDL cells.	Dinoprostone	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
30181697-4	2018	Result demonstrated that IL-8 and IL-11 expression were upregulated in LPA-treated MDA-MB-231 cells.	lysophosphatidic acid	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
30181697-7	2018	In the case of PKC activation, it was observed that PKCdelta and PKCmu might regulate LPA-induced expression of IL-11 and IL-8, respectively, by using specific PKC subtype inhibitors.	lysophosphatidic acid	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
30181697-9	2018	In conclusion, LPA induced the expression of osteolytic cytokines (IL-8 and IL-11) in breast cancer cells by involving different LPA receptors.	lysophosphatidic acid	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
30181697-10	2018	Enhanced expression of IL-8 by LPA may be via ROCK, PKCu, PI3K, and NFkB signaling pathways, while enhanced expression of IL-11 might involve PKCdelta signaling pathway.	lysophosphatidic acid	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
30110956-5	2018	Only the combination of lutein with malvidin-3-glucoside showed anti-inflammatory synergy in the suppression of interleukin-8, and the synergy was seen at all three ratios tested.	3-glucoside	45-56	C-X-C motif chemokine ligand 8	Homo sapiens	112-125
30016752-2	2018	The aim of the study was to evaluate the influence of PDT with delta-aminolevulinic acid (ALA-PDT) used in sub-lethal dose on the interleukins secretion (IL-6, IL-8 and IL-10) by the residual colon cancer cells (CCC) under hypoxia-like conditions (addition of cobalt chloride- CoCl2).	Aminolevulinic Acid	63-88	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
30016752-2	2018	The aim of the study was to evaluate the influence of PDT with delta-aminolevulinic acid (ALA-PDT) used in sub-lethal dose on the interleukins secretion (IL-6, IL-8 and IL-10) by the residual colon cancer cells (CCC) under hypoxia-like conditions (addition of cobalt chloride- CoCl2).	Alanine	90-93	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
30016752-6	2018	After ALA-PDT we found no change in the IL-6 level secreted by SW480 cells, but decrease of IL-6, IL-10 secretion by SW620 cells, an increase in the IL-8 secreted by both cells lines.	Alanine	6-9	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
29901427-8	2018	Ferulic acid significantly ameliorated HUVEC radiation injury, as evidenced by increases in cell viability and angiogenesis and decreases in G2/M cell cycle arrest and levels of high mobility group box 1 protein (HMGB1), interleukin (IL)-6 and IL-8.	ferulic acid	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	244-248
30157189-9	2018	Pre-treatment with vitamin D decreased CXCL8 and further decreased IL-6 production in PM-stimulated cultures, an effect abrogated by inhibition of G6PD with DHEA, supporting a role for this pathway in the anti-inflammatory actions of vitamin D.	Vitamin D	19-28	C-X-C motif chemokine ligand 8	Homo sapiens	39-44
29953960-0	2018	Exosomes derived from calcium oxalate-exposed macrophages enhance IL-8 production from renal cells, neutrophil migration and crystal invasion through extracellular matrix.	Calcium Oxalate	22-37	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
30089134-5	2018	Suppression or neutralization of the BZ-induced IL-8 potentiates the BZ cytotoxic and anti-proliferative effect in TNBC cells.	Bortezomib	37-39	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
30089134-5	2018	Suppression or neutralization of the BZ-induced IL-8 potentiates the BZ cytotoxic and anti-proliferative effect in TNBC cells.	Bortezomib	69-71	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
30123110-0	2018	Role of CXCR1 and Interleukin-8 in Methamphetamine-Induced Neuronal Apoptosis.	Methamphetamine	35-50	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
30123110-10	2018	In addition, IL-8 expression and release were increased in METH-exposed U87MG cells, which is regulated by NF-kappaB pathway.	Methamphetamine	59-63	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
30123110-11	2018	Neuronal apoptosis was attenuated by siCXCR1 after METH treatment in the co-cultured cells, which can be reversed after exposure to recombinant IL-8.	Methamphetamine	51-55	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
30123110-13	2018	Highlights -Methamphetamine exposure upregulated the expression of CXCR1.-Methamphetamine exposure increased the expression of interleukin-8 through nuclear factor-kappa B pathway.-Activation of CXCR1 by interleukin-8 induces an increase in methamphetamine-related neuronal apoptosis.	Methamphetamine	12-27	C-X-C motif chemokine ligand 8	Homo sapiens	127-140
30123110-13	2018	Highlights -Methamphetamine exposure upregulated the expression of CXCR1.-Methamphetamine exposure increased the expression of interleukin-8 through nuclear factor-kappa B pathway.-Activation of CXCR1 by interleukin-8 induces an increase in methamphetamine-related neuronal apoptosis.	Methamphetamine	12-27	C-X-C motif chemokine ligand 8	Homo sapiens	204-217
30123110-13	2018	Highlights -Methamphetamine exposure upregulated the expression of CXCR1.-Methamphetamine exposure increased the expression of interleukin-8 through nuclear factor-kappa B pathway.-Activation of CXCR1 by interleukin-8 induces an increase in methamphetamine-related neuronal apoptosis.	Methamphetamine	74-89	C-X-C motif chemokine ligand 8	Homo sapiens	127-140
30123110-13	2018	Highlights -Methamphetamine exposure upregulated the expression of CXCR1.-Methamphetamine exposure increased the expression of interleukin-8 through nuclear factor-kappa B pathway.-Activation of CXCR1 by interleukin-8 induces an increase in methamphetamine-related neuronal apoptosis.	Methamphetamine	74-89	C-X-C motif chemokine ligand 8	Homo sapiens	204-217
30123110-13	2018	Highlights -Methamphetamine exposure upregulated the expression of CXCR1.-Methamphetamine exposure increased the expression of interleukin-8 through nuclear factor-kappa B pathway.-Activation of CXCR1 by interleukin-8 induces an increase in methamphetamine-related neuronal apoptosis.	Methamphetamine	241-256	C-X-C motif chemokine ligand 8	Homo sapiens	127-140
30123110-13	2018	Highlights -Methamphetamine exposure upregulated the expression of CXCR1.-Methamphetamine exposure increased the expression of interleukin-8 through nuclear factor-kappa B pathway.-Activation of CXCR1 by interleukin-8 induces an increase in methamphetamine-related neuronal apoptosis.	Methamphetamine	241-256	C-X-C motif chemokine ligand 8	Homo sapiens	204-217
30174784-3	2018	The redox cascade during sepsis is mainly initiated by IL-6 and IL-8 stimulation in newborns and includes multiple noxious processes, as direct cell damage induced by reactive oxygen species, activation of gene expression leading to amplification of inflammation and oxidative stress, and impairment of mitochondrial function.	Reactive Oxygen Species	167-190	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
30186283-9	2018	Results: Both primary monocytes and THP-1 cells, a human monocytic cell line, respond strongly to CaOx crystals in a dose-dependent manner producing TNF-alpha, IL-1beta, IL-8, and IL-10 transcripts.	caox crystals	98-111	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
30109169-9	2018	IL-8 was increased in sunitinib-resistant Caki-2 and SN12K1 cells and decreased in 786-0 without any significant changes in Caki-1.	Sunitinib	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
30021676-8	2018	Remarkably, CIC formation was significantly inhibited by IL-8 knockdown and enhanced upon recombinant IL-8 treatment, which correlated with altered cell-cell adhesion and expression of adhesive molecules such as P-cadherin and gamma-catenin.	cic	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
29902421-0	2018	An impedimetric immunosensor for highly sensitive detection of IL-8 in human serum and saliva samples: A new surface modification method by 6-phosphonohexanoic acid for biosensing applications.	6-phosphonohexanoic Acid	140-164	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
29902421-1	2018	In this study, we fabricated a sensitive and label-free impedimetric immunosensor based on 6-phosphonohexanoic acid (PHA) modified ITO electrode for detection of interleukin-8 (IL-8) in human serum and saliva.	6-phosphonohexanoic Acid	91-115	C-X-C motif chemokine ligand 8	Homo sapiens	162-175
29902421-1	2018	In this study, we fabricated a sensitive and label-free impedimetric immunosensor based on 6-phosphonohexanoic acid (PHA) modified ITO electrode for detection of interleukin-8 (IL-8) in human serum and saliva.	6-phosphonohexanoic Acid	91-115	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
29902421-1	2018	In this study, we fabricated a sensitive and label-free impedimetric immunosensor based on 6-phosphonohexanoic acid (PHA) modified ITO electrode for detection of interleukin-8 (IL-8) in human serum and saliva.	1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-hexanoylamine	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	162-175
29902421-1	2018	In this study, we fabricated a sensitive and label-free impedimetric immunosensor based on 6-phosphonohexanoic acid (PHA) modified ITO electrode for detection of interleukin-8 (IL-8) in human serum and saliva.	1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-hexanoylamine	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
30197422-3	2018	2% agarose gel electrophoresis revealed a predominance of IL-8 in the chronic inflammatory palatine tonsil group compared to tonsillar hyperplasia.	Sepharose	3-10	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
30208836-5	2018	SO, ED, and GL stimulated production of pro-inflammatory IFN-gamma, IL-1beta, IL-2, IL-6, IL-8, TNF-alpha and anti-inflammatory IL-10.	glycylleucine	12-14	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
30021676-8	2018	Remarkably, CIC formation was significantly inhibited by IL-8 knockdown and enhanced upon recombinant IL-8 treatment, which correlated with altered cell-cell adhesion and expression of adhesive molecules such as P-cadherin and gamma-catenin.	cic	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
29709340-12	2018	Pretreatment and co-incubation of pulp cells by 5z-7oxozeaenol (1 and 2.5 muM) and U0126 (10 and 20 muM) prevented the IL-1beta-induced IL-8 and uPA expression.	5-7-oxo-zeaenol	48-62	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
29701288-16	2018	Within the limit of this study, the results showed that 12 weeks after BAHS implantation the gene expression of some inflammatory cytokines (IL-8 and IL-1beta) is still relatively high compared with the baseline, steady-state, expression.	bahs	71-75	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
29890415-6	2018	Montelukast has an inhibitory effect on the inflammatory microenvironment of RA by decreasing the secretion of IL-6, IL-8, MMP-3 and MMP-13 in FLSs induced by IL-1beta.	montelukast	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
29935159-5	2018	In a glucocorticoid resistance model using human monocytes (THP-1 cell line) differentiated into macrophage-like cells we observed that exposure to 1 mM tertiary butyl hydroperoxide (t-BuOOH) for 4 h significantly hampered the anti-inflammatory action of cortisol assessed as attenuation of the interleukin (IL)-8 production.	n-Butylhydroperoxide	162-181	C-X-C motif chemokine ligand 8	Homo sapiens	295-313
29935159-5	2018	In a glucocorticoid resistance model using human monocytes (THP-1 cell line) differentiated into macrophage-like cells we observed that exposure to 1 mM tertiary butyl hydroperoxide (t-BuOOH) for 4 h significantly hampered the anti-inflammatory action of cortisol assessed as attenuation of the interleukin (IL)-8 production.	di-tert-butyl peroxide	183-190	C-X-C motif chemokine ligand 8	Homo sapiens	295-313
29396047-0	2018	Fisetin inhibits TNF-alpha/NF-kappaB-induced IL-8 expression by targeting PKCdelta in human airway epithelial cells.	fisetin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
30092684-5	2018	Our findings indicate that SBDE-mediated pro-inflammatory effects are predominantly due to the induction of neutrophilic chemokine IL-8.	sbde	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
28679068-0	2018	Berberine hydrochloride counteracts enhanced IL-8 expression induced by SN 38 in AGS cells.	berberine chloride	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
28679068-0	2018	Berberine hydrochloride counteracts enhanced IL-8 expression induced by SN 38 in AGS cells.	Irinotecan	72-77	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
28679068-3	2018	BER could down-regulate the enhanced IL-8 expression through down-regulating ERK1/2 and p38 MAPK over-activation induced by SN 38.	Irinotecan	124-129	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
28679068-4	2018	The increased IL-8 mediated adhesive ability of AGS cells to HUVECs induced by SN 38, could be reduced by BER.	Irinotecan	79-84	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
29709340-12	2018	Pretreatment and co-incubation of pulp cells by 5z-7oxozeaenol (1 and 2.5 muM) and U0126 (10 and 20 muM) prevented the IL-1beta-induced IL-8 and uPA expression.	U 0126	83-88	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
29709340-13	2018	5z-7oxozeaenol and U0126 also attenuated the IL-1beta-induced IL-8 and uPA secretion.	5-7-oxo-zeaenol	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
29709340-13	2018	5z-7oxozeaenol and U0126 also attenuated the IL-1beta-induced IL-8 and uPA secretion.	U 0126	19-24	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
30018026-4	2018	Mutational analysis of the IL-8 promoter revealed that it was not the AP-1 binding site, but rather the NF-kappaB site that was essential to connect resveratrol stimulation with the transcriptional activation of the IL-8 gene.	Resveratrol	149-160	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
29928974-5	2018	We found that the ability to inhibit IL-8 secretion correlated with the amount of proanthocyanidins and was associated to the not edible parts of chestnut in all the tested varieties.	Proanthocyanidins	82-99	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
29928974-8	2018	The bioactive components of chestnut fruits inhibit IL-8 secretion by impairing NF-kappaB signaling and by other mechanisms, thus opening new applications of proanthocyanidins for inflammation-based diseases.	Proanthocyanidins	158-175	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
29901202-0	2018	CXCL8 and CXCL11 chemokine secretion in dermal fibroblasts is differentially modulated by vanadium pentoxide.	vanadium pentoxide	90-108	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
30018026-0	2018	Resveratrol stimulation induces interleukin-8 gene transcription via NF-kappaB.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	32-45
30018026-4	2018	Mutational analysis of the IL-8 promoter revealed that it was not the AP-1 binding site, but rather the NF-kappaB site that was essential to connect resveratrol stimulation with the transcriptional activation of the IL-8 gene.	Resveratrol	149-160	C-X-C motif chemokine ligand 8	Homo sapiens	216-220
30018026-2	2018	As part of a search for resveratrol-regulated target genes we analyzed the gene encoding the chemokine interleukin-8 (IL-8) which is regulated by AP-1.	Resveratrol	24-35	C-X-C motif chemokine ligand 8	Homo sapiens	103-116
30018026-2	2018	As part of a search for resveratrol-regulated target genes we analyzed the gene encoding the chemokine interleukin-8 (IL-8) which is regulated by AP-1.	Resveratrol	24-35	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
30018026-5	2018	Thus, the NF-kappaB site of the IL-8 gene functions as resveratrol-responsive element.	Resveratrol	55-66	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
30018026-3	2018	Here, we show that treatment of HEK293 cells with resveratrol induced the expression of IL-8 and activated transcription of a chromatin-embedded IL-8 promoter-controlled reporter gene.	Resveratrol	50-61	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
30018026-3	2018	Here, we show that treatment of HEK293 cells with resveratrol induced the expression of IL-8 and activated transcription of a chromatin-embedded IL-8 promoter-controlled reporter gene.	Resveratrol	50-61	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
30018026-7	2018	These data were corroborated by an experiment showing that incubation of the cells with the NF-kappaB inhibitor JSH-23 attenuated resveratrol-induced activation of the IL-8 promoter and reduced the cellular NF-kappaB activity following stimulation of the cells with resveratrol.	Resveratrol	130-141	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
30018026-8	2018	The protein kinase extracellular signal-regulated protein kinase ERK1/2 was identified to function as signal transducer connecting resveratrol stimulation with the activation of NF-kappaB and IL-8 promoter-controlled transcription.	Resveratrol	131-142	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
30018026-9	2018	We conclude that resveratrol, proposed to exhibit anti-inflammatory activity, stimulates expression of the pro-inflammatory chemokine IL-8 via NF-kappaB, which is known as an important mediator of inflammatory processes.	Resveratrol	17-28	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
30078983-10	2018	Both CE-CKC emulsions inhibited the secretion of IL-17 (from anti-CD3/anti-CD28-stimulated TCD4), TNFalpha, IFN-gamma, and IL-2 (from anti-CD3-/anti-CD28-stimulated PBMCs), and IL-6 and IL-8 (from LPS-stimulated HCE-2).	ce-ckc	5-11	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
29105595-12	2018	The 1,25-(OH)2 induction of cathelicidin and suppression of IL-8 highlights a mechanism by which 1,25-(OH)2 supplementation could enhance the pregnant innate immune defenses.	1,25-(oh)2	97-107	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
32559970-8	2018	Silicon, tin and fluoride ions were recovered together (Na2SiF6 + Na2SnF6 + NaF) by careful evaporation of the aqueous solution after SX of nickel.	Silicon	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
32559970-8	2018	Silicon, tin and fluoride ions were recovered together (Na2SiF6 + Na2SnF6 + NaF) by careful evaporation of the aqueous solution after SX of nickel.	Fluorides	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
30040868-14	2018	CONCLUSION: CS exposure downregulates the expression levels of EP2 and EP4 receptors and stimulates the production of PGE2 and the proinflammatory cytokine IL-8 and TNF-alpha in polyp tissues of CRS patients.	Cesium	12-14	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
30078983-12	2018	In addition, tyloxapol, another excipient, showed some anti-inflammatory activity on IL-6 and IL-8 in the LPS-stimulated HCE-2 cells.	tyloxapol	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
30026883-10	2018	The antioxidant N-acetyl-L-cysteine significantly inhibited the increases in interleukin-8 induced by solutions with particulate matter, regardless of ozone exposure.	Acetylcysteine	16-35	C-X-C motif chemokine ligand 8	Homo sapiens	77-90
30026883-12	2018	Conclusion: Ozone may augment the production of interleukin-8 in response to ambient particulate matter by a mechanism unrelated to reactive oxygen species.	Ozone	12-17	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
28736254-0	2018	Bisphenol A affects trophoblast invasion by inhibiting CXCL8 expression in decidual stromal cells.	bisphenol A	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	55-60
30093956-9	2018	Vincamine also exerted anti-inflammatory activities by decreasing IL-6, IL-8, IL-1beta, TNF-alpha, TGF-beta expression.	Vincamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
28736254-4	2018	We found that BPA significantly inhibited CXCL8 expression in DSCs, which hindered trophoblast invasion, and activated the phosphorylation of ERK in DSCs.	bisphenol A	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	42-47
28736254-5	2018	U0126, an inhibitor of ERK activation, remarkably rescued trophoblast invasion and the inhibition of CXCL8 expression caused by BPA treatment.	U 0126	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	101-106
28736254-5	2018	U0126, an inhibitor of ERK activation, remarkably rescued trophoblast invasion and the inhibition of CXCL8 expression caused by BPA treatment.	bisphenol A	128-131	C-X-C motif chemokine ligand 8	Homo sapiens	101-106
29678503-6	2018	Cytokine levels of IL-8, MIP-1beta, IL-6, IFN-gamma, GM-CSF, TNF, IL-2, IL-4, MCP-1, and IL-10 were decreased significantly with caffeine treatment.	Caffeine	129-137	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
29980718-9	2018	In addition, EhJAB1 binding blocked EhMIF-induced IL-8 production by human epithelial cells.	ehmif	36-41	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
30022950-3	2018	TMA also demonstrated anti-inflammatory properties, via reduction of IL-8 expression, thus making TMA a promising agent for treatment of cystic fibrosis.	4,4',6-trimethylangelicin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
30022950-3	2018	TMA also demonstrated anti-inflammatory properties, via reduction of IL-8 expression, thus making TMA a promising agent for treatment of cystic fibrosis.	4,4',6-trimethylangelicin	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
29473951-7	2018	By contrast, low concentrations of 4-HNE, niacin and 3-OHBA down-regulated the expression of pro-inflammatory cytokines IL-6 and IL-8.	4-hydroxy-2-nonenal	35-40	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
29473951-7	2018	By contrast, low concentrations of 4-HNE, niacin and 3-OHBA down-regulated the expression of pro-inflammatory cytokines IL-6 and IL-8.	Niacin	42-48	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
29473951-7	2018	By contrast, low concentrations of 4-HNE, niacin and 3-OHBA down-regulated the expression of pro-inflammatory cytokines IL-6 and IL-8.	3-ohba	53-59	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
30002111-1	2018	The aim of this research study was to determine the role of 18F-Sodium fluoride (NaF) PET/CT imaging in the assessment of physiologic molecular calcification in the intra-cranial structures.	Sodium Fluoride	64-79	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
30002111-10	2018	NaF uptake significantly correlated with HU in the right choroid plexus (r=0.52, P &lt; 0.0001), left choroid plexus (r=0.57, p&lt;0.0001), and epithalamus (r=0.25, P = 0.03).	Hydroxyurea	41-43	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
29980681-4	2018	Blocking ERK activation using a MEK inhibitor (U0126) suppressed NE-induced IL-8 secretion and knockdown of proteinase-activated receptor 2 (PAR2) using siRNAs inhibited both NE-induced ERK activation and subsequent IL-8 release, suggesting that NE-induced IL-8 production is dependent on PAR2-mediated ERK activation.	U 0126	47-52	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
29973256-2	2018	Functionalized tricalcium phosphate (fTCP) has been incorporated into sodium fluoride (NaF) varnish to enhance the remineralization process.	tricalcium phosphate	15-35	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
29973256-2	2018	Functionalized tricalcium phosphate (fTCP) has been incorporated into sodium fluoride (NaF) varnish to enhance the remineralization process.	4-Fluoro-1-(1-(2-thienyl)cyclohexyl)piperidine	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
29973256-2	2018	Functionalized tricalcium phosphate (fTCP) has been incorporated into sodium fluoride (NaF) varnish to enhance the remineralization process.	Sodium Fluoride	70-85	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
29973256-3	2018	NaF varnish with the adjunctive application of silver nitrate (AgNO3) solution is effective in arresting dentine caries.	Silver Nitrate	47-61	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
29973256-3	2018	NaF varnish with the adjunctive application of silver nitrate (AgNO3) solution is effective in arresting dentine caries.	Silver Nitrate	63-68	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
29973256-12	2018	DISCUSSION: The effectiveness of the topical application of a 25% AgNO3 solution followed by a 5% NaF varnish with fTCP in arresting coronal dentine caries among preschool children remains unknown.	4-Fluoro-1-(1-(2-thienyl)cyclohexyl)piperidine	115-119	C-X-C motif chemokine ligand 8	Homo sapiens	98-101
29512121-10	2018	Paradoxically, ketorolac increased the release of CXCL1 and IL-8 in prostaglandin E2 and chondroitin sulphate-stimulated synovial cells in vitro.	Ketorolac	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
29512121-10	2018	Paradoxically, ketorolac increased the release of CXCL1 and IL-8 in prostaglandin E2 and chondroitin sulphate-stimulated synovial cells in vitro.	Dinoprostone	68-84	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
29512121-10	2018	Paradoxically, ketorolac increased the release of CXCL1 and IL-8 in prostaglandin E2 and chondroitin sulphate-stimulated synovial cells in vitro.	Chondroitin Sulfates	89-109	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
29702023-1	2018	OBJECTIVE: The aim of this article is to present examples in which sodium fluoride labelled with 18F (NaF) bone PET/CT would be a useful adjunct to guide complex clinical decisions about the staging, restaging, and treatment approach for patients with skeletal metastases and benign causes of NaF activity that can be mistaken for bone metastases.	Sodium Fluoride	67-82	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
29702023-1	2018	OBJECTIVE: The aim of this article is to present examples in which sodium fluoride labelled with 18F (NaF) bone PET/CT would be a useful adjunct to guide complex clinical decisions about the staging, restaging, and treatment approach for patients with skeletal metastases and benign causes of NaF activity that can be mistaken for bone metastases.	Sodium Fluoride	67-82	C-X-C motif chemokine ligand 8	Homo sapiens	293-296
29221667-12	2018	In vitro IL-8 production by IL-27 and IL-37 pre-treated neutrophils and monocytes was significantly inhibited even after heme addition.	Heme	121-125	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
29555399-2	2018	Given the similarities in vascular calcification and bone formation, 18F-sodium fluoride (18F-NaF) is now considered a novel marker of vascular calcification.	18f-sodium fluoride	69-88	C-X-C motif chemokine ligand 8	Homo sapiens	94-97
29749433-11	2018	Results from the present study suggested that reparixin and SCH527123 may be promising therapeutic agents for the treatment of pancreatic cancer by inhibiting the IL-8/CXCR1/2 signaling cascade.	2-hydroxy-N,N-dimethyl-3-(2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-enylamino)benzamide	60-69	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
30016181-13	2018	As expected, UFH decreased LPS-induced IL-1beta, TNF-alpha, IL-6, IL-8, and IL-18 protein levels, suggesting that UFH has an anti-inflammatory effect on THP-1 cells by interrupting the MAPK, NF-kappaB, and c-Jun signaling pathways.	Heparin	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
29630729-0	2018	Rho-kinase inhibitor Y-27632 downregulates LPS-induced IL-6 and IL-8 production via blocking p38 MAPK and NF-kappaB pathways in human gingival fibroblasts.	Y 27632	21-28	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
29630729-13	2018	CONCLUSIONS: Rho-kinase inhibitor Y-27632 downregulates LPS-induced IL-6 and IL-8 production by blocking NF-kappaB and p38 MAPK activation in HGFs.	Y 27632	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
29803436-13	2018	Interestingly, a microbial combination producing high amounts of butyrate was able to reduce IL-8 expression in HT-29 cells co-incubated with TNFalpha.	Butyrates	65-73	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
29758489-4	2018	Fisetin significantly inhibited COX-2 expression and reduced prostaglandin E2 production, and it suppressed the levels of IL-8, CCL5, monocyte chemotactic protein 1, tumor necrosis factor alpha, and IL-6.	fisetin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
29749433-8	2018	Treatment with either reparixin or SCH527123 yielded dose-dependent growth suppressive effects on HPAC, Capan-1 and AsPC-1 cells that may have otherwise undergone robust proliferation upon IL-8 stimulation.	reparixin	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
29749433-8	2018	Treatment with either reparixin or SCH527123 yielded dose-dependent growth suppressive effects on HPAC, Capan-1 and AsPC-1 cells that may have otherwise undergone robust proliferation upon IL-8 stimulation.	2-hydroxy-N,N-dimethyl-3-(2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-enylamino)benzamide	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
29749433-9	2018	In addition, reparixin or SCH527123 treatment inhibited CXCR1/2-mediated signal transduction, as demonstrated by the decreased phosphorylation levels of effector molecules STAT3, AKT, ERK and S6 that are downstream of the IL-8/CXCR1/2 signaling cascade in HPAC cells.	reparixin	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	222-226
29749433-9	2018	In addition, reparixin or SCH527123 treatment inhibited CXCR1/2-mediated signal transduction, as demonstrated by the decreased phosphorylation levels of effector molecules STAT3, AKT, ERK and S6 that are downstream of the IL-8/CXCR1/2 signaling cascade in HPAC cells.	2-hydroxy-N,N-dimethyl-3-(2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-enylamino)benzamide	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	222-226
29749433-11	2018	Results from the present study suggested that reparixin and SCH527123 may be promising therapeutic agents for the treatment of pancreatic cancer by inhibiting the IL-8/CXCR1/2 signaling cascade.	reparixin	46-55	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
30016181-13	2018	As expected, UFH decreased LPS-induced IL-1beta, TNF-alpha, IL-6, IL-8, and IL-18 protein levels, suggesting that UFH has an anti-inflammatory effect on THP-1 cells by interrupting the MAPK, NF-kappaB, and c-Jun signaling pathways.	Heparin	114-117	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
30938600-2	2018	In previous studies, povidone iodine (PVP-I), a widely used bactericidal antiseptic, and sodium fluoride (NaF), used to foster remineralization of enamel, were applied sequentially topically and shown to be safe and effective.	Sodium Fluoride	89-104	C-X-C motif chemokine ligand 8	Homo sapiens	106-109
30938600-3	2018	The study aim was to characterize the kinetics of iodine and fluoride following topical application of a single combination PVP-I and NaF anticaries varnish in healthy adults.	Iodine	50-56	C-X-C motif chemokine ligand 8	Homo sapiens	134-137
30938600-3	2018	The study aim was to characterize the kinetics of iodine and fluoride following topical application of a single combination PVP-I and NaF anticaries varnish in healthy adults.	Fluorides	61-69	C-X-C motif chemokine ligand 8	Homo sapiens	134-137
29555399-11	2018	A negative correlation was observed between 18F-NaF uptake and smooth muscle cell staining (IOD: r = -.710, P = .049).	Fluorine-18	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
29966605-0	2018	Clioquinol increases the expression of interleukin-8 by down-regulating GATA-2 and GATA-3.	Clioquinol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
29704670-5	2018	The results demonstrated that isorhamnetin attenuated LPS-induced release of PGE2, NO, IL-6, and IL-8 in HGFs.	3-methylquercetin	30-42	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
29966605-10	2018	Electrophoresis mobility shift assays using a probe corresponding to -159/-113 of the human IL-8 gene revealed two major shifted bands, one of which was increased and the other was decreased by clioquinol.	Clioquinol	194-204	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
29966605-5	2018	The global analysis and quantitative PCR demonstrated that the mRNA level of interleukin-8 (IL-8) was significantly increased when SH-SY5Y neuroblastoma cells were treated with clioquinol.	Clioquinol	177-187	C-X-C motif chemokine ligand 8	Homo sapiens	77-90
29966605-5	2018	The global analysis and quantitative PCR demonstrated that the mRNA level of interleukin-8 (IL-8) was significantly increased when SH-SY5Y neuroblastoma cells were treated with clioquinol.	Clioquinol	177-187	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
29966605-13	2018	Genome editing against GATA-2 or GATA-3, not GATA-4 significantly enhanced clioquinol-induced IL-8 mRNA expression.	Clioquinol	75-85	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
29966605-6	2018	An enzyme-linked immunosorbent assay also demonstrated that clioquinol induced the secretion of IL-8 into culture media.	Clioquinol	60-70	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
29966605-14	2018	On the other hand, the stable expression of GATA-2 or GATA-3 attenuated clioquinol-induced IL-8 mRNA expression and IL-8 secretion.	Clioquinol	72-82	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
29966605-7	2018	Promoter analyses on SH-SY5Y cells revealed that a region responsive to clioquinol exists between -152 and -144 of the human IL-8 gene, which contains a consensus GATA-binding site sequence.	Clioquinol	72-82	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
29966605-14	2018	On the other hand, the stable expression of GATA-2 or GATA-3 attenuated clioquinol-induced IL-8 mRNA expression and IL-8 secretion.	Clioquinol	72-82	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
29966605-15	2018	These results suggest that the clioquinol-induced suppression of GATA-2 and GATA-3 expression mediates the up-regulation of IL-8.	Clioquinol	31-41	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
29508465-7	2018	Knockdown of Nrf2 attenuated the effect of casticin on production of IL-6 and IL-8, expression of MUC5AC, collagen type I, and fibronectin in 16-HBE cells.	casticin	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
29508465-5	2018	The results showed that lipopolysaccharide induced the mRNA and protein levels of IL-6, IL-8, MUC5AC, collagen type I, and fibronectin in 16-HBE cells, whereas casticin treatment significantly inhibited the induction of lipopolysaccharide.	casticin	160-168	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
29425105-5	2018	RESULTS: In this study, using R&amp;D Systems ELISA kits, EDTA plasma samples and serum samples with a pre-centrifugation delay longer than 24 h had an IL16 concentration higher than 313 pg/mL, and an IL8 concentration higher than 125 pg/mL, respectively.	Edetic Acid	58-62	C-X-C motif chemokine ligand 8	Homo sapiens	201-204
29793168-5	2018	Oxysterols treatment significantly altered differentiated Caco-2 cells redox status, leading to oxidant species production and a decrease of GSH levels, after 1 h exposure, followed by an increase of cytokines production, IL-6 and IL-8, after 24 h. Oxysterol cell treatment also induced after 48 h an increase of NO release, due to the induction of iNOS.	Oxysterols	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	231-235
29793168-5	2018	Oxysterols treatment significantly altered differentiated Caco-2 cells redox status, leading to oxidant species production and a decrease of GSH levels, after 1 h exposure, followed by an increase of cytokines production, IL-6 and IL-8, after 24 h. Oxysterol cell treatment also induced after 48 h an increase of NO release, due to the induction of iNOS.	Oxysterols	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	231-235
30034287-1	2018	We incidentally identified gallbladder activity on 18F sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) bone images in five patients.	Sodium Fluoride	55-70	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
29425105-6	2018	EDTA plasma samples with a pre-centrifugation delay longer than 48 h had an IL16 concentration higher than 897 pg/mL, citrate plasma samples had an IL8 concentration higher than 21.5 pg/mL and serum samples had an IL8 concentration higher than 528 pg/mL.	Edetic Acid	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	214-217
29425105-6	2018	EDTA plasma samples with a pre-centrifugation delay longer than 48 h had an IL16 concentration higher than 897 pg/mL, citrate plasma samples had an IL8 concentration higher than 21.5 pg/mL and serum samples had an IL8 concentration higher than 528 pg/mL.	Citric Acid	118-125	C-X-C motif chemokine ligand 8	Homo sapiens	148-151
29925859-8	2018	We observed a significant correlation between ERK1/2 phosphorylation and IL-8 expression, suggesting that ERK1/2 modulates the ozone-mediated IL-8 response; however, we found that simultaneous inhibition of both kinases was required to achieve the greatest IL-8 inhibition.	Ozone	127-132	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
29940963-6	2018	RESULTS: TBEC and AMs showed stronger pro-inflammatory cytokine (e.g., IL-8) responses to PIC and LPS, respectively.	tbec	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
29940963-6	2018	RESULTS: TBEC and AMs showed stronger pro-inflammatory cytokine (e.g., IL-8) responses to PIC and LPS, respectively.	Poly I-C	90-93	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
29940963-11	2018	PIC-stimulated TBEC and LPS-stimulated AMs from smokers vs. non-smokers produced more IL-8.	Poly I-C	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
29932110-6	2018	Of these, only (2-(1,2-diphenyl-1H-indol-3-yl)ethanamine (DPIE) showed a synergistic increase in inflammatory molecules and cytokine production (IL-6, IL-8, and COX-2) at both mRNA and protein levels in IL-1&amp;beta;-stimulated GFs.	1,2-Diphenyltryptamine	16-56	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
29932110-6	2018	Of these, only (2-(1,2-diphenyl-1H-indol-3-yl)ethanamine (DPIE) showed a synergistic increase in inflammatory molecules and cytokine production (IL-6, IL-8, and COX-2) at both mRNA and protein levels in IL-1&amp;beta;-stimulated GFs.	dpie	58-62	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
29925859-7	2018	Recent evidence suggests that the MAP kinases ERK1/2 and p38 mediate ozone-induced IL-8 transcription, thus we hypothesized that differences in their activation may control IL-8 inter-individual variability.	Ozone	69-74	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
29925859-7	2018	Recent evidence suggests that the MAP kinases ERK1/2 and p38 mediate ozone-induced IL-8 transcription, thus we hypothesized that differences in their activation may control IL-8 inter-individual variability.	Ozone	69-74	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
29924840-9	2018	In general, the crude leaf extracts amplified the anti-inflammatory response when compared with ketoprofen, particularly reducing the production of IL-8, a mediator involved in neutrophil recruitment during tissue damage.	Ketoprofen	96-106	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
29925859-8	2018	We observed a significant correlation between ERK1/2 phosphorylation and IL-8 expression, suggesting that ERK1/2 modulates the ozone-mediated IL-8 response; however, we found that simultaneous inhibition of both kinases was required to achieve the greatest IL-8 inhibition.	Ozone	127-132	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
29925859-8	2018	We observed a significant correlation between ERK1/2 phosphorylation and IL-8 expression, suggesting that ERK1/2 modulates the ozone-mediated IL-8 response; however, we found that simultaneous inhibition of both kinases was required to achieve the greatest IL-8 inhibition.	Ozone	127-132	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
29865262-6	2018	Simvastatin or fluvastatin caused IL-8 (interleukin-8) suppression, but increased hBD-2 mRNA expression in Salmonella-infected SW480 cells.	Simvastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
29704506-10	2018	RSV also inhibited inflammation injury of HaCaT cells by reducing productions of IL-6, IL-8, and TNF-alpha.	Resveratrol	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
29660434-8	2018	BDP/FOR and SB203580 showed the highest inhibitory effect on epithelial IL-8, whereas endothelial ICAM-1 was never affected by BDP/FOR and PDTC.	SB 203580	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
29899223-8	2018	In contrast, patients with high pre-interventional IL-6 and IL-8 serum levels not only poorly responded to TACE but had a significantly impaired overall survival.	Chlorotrianisene	107-111	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
29922598-8	2018	Psoralen and angelicin also markedly decreased the mRNA expression and release of inflammatory cytokines (interleukin [IL]-1beta and IL-8) by THP-1 cells in a dose-dependent manner.	Ficusin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
29922598-8	2018	Psoralen and angelicin also markedly decreased the mRNA expression and release of inflammatory cytokines (interleukin [IL]-1beta and IL-8) by THP-1 cells in a dose-dependent manner.	angelicin	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
29895782-2	2018	EtOH increased senescence activity, levels of reactive oxygen species (ROS) and the expression of cell cycle regulators (p53, p21 and p16) and senescence-associated secretory phenotype (SASP) genes (interleukin [IL]-1beta, IL-6, IL-8 and tumor necrosis factor-alpha) in HPDLCs and cementoblasts.	Ethanol	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	229-265
29865262-6	2018	Simvastatin or fluvastatin caused IL-8 (interleukin-8) suppression, but increased hBD-2 mRNA expression in Salmonella-infected SW480 cells.	Fluvastatin	15-26	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
29446169-5	2018	RESULTS: Physiological normoxia (5% O2 ) decreased SA-beta-Gal-positive cells and SASP including interleukin-6 (IL-6) and IL-8 compared with cultured cells in 21% O2 .	Oxygen	36-38	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
29368548-5	2018	We found that the omega-6 PUFA arachidonic acid (AA), but not omega-3 PUFAs or SFAs, upregulates IL-6 and CXCL8 release.	omega-6 pufa	18-30	C-X-C motif chemokine ligand 8	Homo sapiens	106-111
29693201-0	2018	IL-8 regulates the doxorubicin resistance of colorectal cancer cells via modulation of multidrug resistance 1 (MDR1).	Doxorubicin	19-30	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
29368548-5	2018	We found that the omega-6 PUFA arachidonic acid (AA), but not omega-3 PUFAs or SFAs, upregulates IL-6 and CXCL8 release.	Arachidonic Acid	31-47	C-X-C motif chemokine ligand 8	Homo sapiens	106-111
29334172-1	2018	We have previously reported that silica nanoparticles (SiNPs) of nominal size 50 nm (Si50) induce the pro-inflammatory cytokines CXCL8 and IL-6 in BEAS-2B cells, via mechanisms involving MAPK p38, TACE-mediated TGF-alpha release and the NF-kappaB pathway.	Silicon Dioxide	33-39	C-X-C motif chemokine ligand 8	Homo sapiens	129-134
29693201-3	2018	Cytokine expression analysis revealed that IL-8, while not FGF-2, EGF, TGF-beta, IL-6, or IL-10, was significantly increased in Dox-resistant CRC cells as compared with their corresponding parental cells.	Doxorubicin	128-131	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
29693201-4	2018	Targeted inhibition of IL-8 via siRNAs or its inhibitor reparixin can increase the Dox sensitivity of HCT-116/Dox and SW480/Dox cells.	Doxorubicin	83-86	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
29693201-4	2018	Targeted inhibition of IL-8 via siRNAs or its inhibitor reparixin can increase the Dox sensitivity of HCT-116/Dox and SW480/Dox cells.	Doxorubicin	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
29693201-4	2018	Targeted inhibition of IL-8 via siRNAs or its inhibitor reparixin can increase the Dox sensitivity of HCT-116/Dox and SW480/Dox cells.	Doxorubicin	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
29693201-5	2018	The si-IL-8 can decrease the mRNA and protein expression of multidrug resistance 1 (MDR1, encoded by ABCB1), while has no effect on the expression of multidrug resistance-associated protein 1 (ABCC1), in CRC Dox-resistant cells.	Doxorubicin	208-211	C-X-C motif chemokine ligand 8	Homo sapiens	7-11
29693201-7	2018	BAY 11-7082, the inhibitor of NF-kappaB, suppressed the recombination IL-8 (rIL-8) induced upregulation of ABCB1.	3-(4-methylphenylsulfonyl)-2-propenenitrile	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
29693201-10	2018	These results suggested that IL-8 regulates the Dox resistance of CRC cells via modulation of MDR1 through IKK-beta/p65 signals.	Doxorubicin	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
29693201-11	2018	The targeted inhibition of IL-8 might be an important potential approach to overcome the clinical Dox resistance in CRC patients.	Doxorubicin	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
29581231-0	2018	Intestinal mucin activates human dendritic cells and IL-8 production in a glycan-specific manner.	Polysaccharides	74-80	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
29604316-4	2018	Where present, F was 1150 ppm as NaF; Zn was 0.3% as ZnCl2.	Fluorine	15-16	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
29404796-9	2018	Plasma IL-6 and IL-8 levels after surgery were significantly lower in the PMMA group than in the PS group, while other cytokines measured in this study were not significantly different.	Polymethyl Methacrylate	74-78	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
29404796-11	2018	The continuous use of PMMA-CRRT throughout the perioperative period suppressed serum IL-6 and IL-8 concentrations, although there were no differences in clinical outcomes.	Polymethyl Methacrylate	22-26	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
29431349-3	2018	The aim of our study was to evaluate the effect of active vitamin D3 (VD) on the expression of pro-inflammatory and anti-inflammatory cytokines (IL-6, IL-8, IL-10 and IL-12) in human gingival fibroblasts (hGF) and human periodontal ligament cells (hPDLc) triggered by Porphyromonas gingivalis and Streptococcus pyogenes.	Cholecalciferol	58-68	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
30069319-14	2018	In 16HBE airway cells, H2O2 increased IL-6 and IL-8 secretion in conjunction with ERK1/2 and NF-kappaB activation.	Hydrogen Peroxide	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
29704403-6	2018	In differentiated Caco-2 cell monolayers as a model of the small intestinal epithelium, complexation of gliadin with GTE reduces gliadin-stimulated monolayer permeability and the release of interleukin (IL)-6 and IL-8.	gte	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	213-217
29658573-7	2018	The results indicated that A549 had increased levels of IL-6, IL-8 and TNF-alpha when cultured with nicotine when compared with the control cells.	Nicotine	100-108	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
29027074-0	2018	Uptake of Radium-223 Dichloride and Early [18F]NaF PET Response Are Driven by Baseline [18F]NaF Parameters: a Pilot Study in Castration-Resistant Prostate Cancer Patients.	radium Ra 223 dichloride	10-31	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
29027074-1	2018	PURPOSE: The purpose of this study is to identify predictive factors on baseline [18F]NaF positron emission tomography (PET)/computed tomography (CT) of early response to radium-223 dichloride after 3 cycles of treatment in metastatic castration-resistant prostate cancer patients.	223 dichloride	178-192	C-X-C motif chemokine ligand 8	Homo sapiens	86-89
29027074-14	2018	CONCLUSIONS: SUVmax and SUVmean on baseline [18F]NaF PET/CT are independent predictors of bone lesions" response to 3 cycles of radium-223 dichloride, supporting the use of NaF to select patients more likely to respond to treatment.	radium Ra 223 dichloride	128-149	C-X-C motif chemokine ligand 8	Homo sapiens	173-176
29805673-0	2018	Anesthetic drug propofol inhibits the expression of interleukin-6, interleukin-8 and cyclooxygenase-2, a potential mechanism for propofol in suppressing tumor development and metastasis.	Propofol	129-137	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
29805673-2	2018	The present study demonstrated that propofol may suppress the proliferation of MCF-7 cells and inhibit the expression of interleukin (IL)-6 and IL-8.	Propofol	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
29805673-0	2018	Anesthetic drug propofol inhibits the expression of interleukin-6, interleukin-8 and cyclooxygenase-2, a potential mechanism for propofol in suppressing tumor development and metastasis.	Propofol	16-24	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
29805673-4	2018	Therefore, the mechanism of propofol in suppressing tumor development and metastasis may be associated with the inhibition of IL-6, IL-8 and COX-2.	Propofol	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
29672044-0	2018	Andrographolide Antagonizes TNF-alpha-Induced IL-8 via Inhibition of NADPH Oxidase/ROS/NF-kappaB and Src/MAPKs/AP-1 Axis in Human Colorectal Cancer HCT116 Cells.	andrographolide	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
29656143-2	2018	DESIGN: Both knees of 15 participants with unilateral reconstructed ACL tears and unaffected contralateral knees were scanned using a simultaneous 3.0T PET-MRI system following injection of 18F-sodium fluoride (18F-NaF).	18f-sodium fluoride	190-209	C-X-C motif chemokine ligand 8	Homo sapiens	215-218
29573703-4	2018	The aim of this work was to study the extent of the protective effect of the antioxidant N-acetylcysteine (NAC) over the proinflammatory state (IL-6 and IL-8), oxidative stress (reactive oxygen species, ROS), and CFTR levels, caused by Cigarette Smoke Extract (CSE) in Calu-3 airway epithelial cells.	Acetylcysteine	89-105	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
29573703-4	2018	The aim of this work was to study the extent of the protective effect of the antioxidant N-acetylcysteine (NAC) over the proinflammatory state (IL-6 and IL-8), oxidative stress (reactive oxygen species, ROS), and CFTR levels, caused by Cigarette Smoke Extract (CSE) in Calu-3 airway epithelial cells.	Acetylcysteine	107-110	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
29802207-5	2018	We report that human basophils are refractory to Treg-mediated suppression and found that Tregs stimulate resting basophils to induce the expression of activation markers including CD69, CD203c, and CD13 and the release of basophil cytokines including IL-13, IL-8, and IL-4.	tregs	90-95	C-X-C motif chemokine ligand 8	Homo sapiens	259-263
29510260-7	2018	CONCLUSIONS: ALA-PDT in sublethal doses might influence colon cancer cell"s progression and invasion by reducing the secretion of IL-6, IL-10 and increasing the IL-8 concentration with higher values in the more malignant cell line.	Alanine	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
29477863-7	2018	These divergences in ROS production seem to be correlated with the different extension of intracellular signaling pathways activation and, by consequence, with distinct transcription kinetics of genes such as HMOX1, IL8, IL1B and CD86.	Reactive Oxygen Species	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	216-219
29501468-10	2018	Moderate direct correlations were observed between vitamin D and IL-8, IL-10, and IFN-gamma in the prospective group of 16 brain-dead patients (IL-8: r = 0.5, p = 0.049; IL-10 r = 0.67, p = 0.005; IFN-gamma r = 0.6, p = 0.015).	Vitamin D	51-60	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
29501468-10	2018	Moderate direct correlations were observed between vitamin D and IL-8, IL-10, and IFN-gamma in the prospective group of 16 brain-dead patients (IL-8: r = 0.5, p = 0.049; IL-10 r = 0.67, p = 0.005; IFN-gamma r = 0.6, p = 0.015).	Vitamin D	51-60	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
29501468-13	2018	In brain-dead patients, vitamin D serum levels correlated with plasma IL-8, IL-10 and IFN-gamma.	Vitamin D	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
29672044-4	2018	However, the effect and molecular mechanisms of IL-8 expression by andrographolide remain obscure in human colorectal cancer cells.	andrographolide	67-82	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
29672044-5	2018	The present study was aimed to investigate the effects of andrographolide on TNF-alpha-induced IL-8 expression and its underlying mechanisms.	andrographolide	58-73	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
29875665-10	2018	The GLPG and/or SHB treatments restored the inhibitory effects of acetate on IL-6 and IL-8 production and the inhibitory effects of butyrate or propionate on IL-6 production, but not on IL-8.	Acetates	66-73	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
29672044-6	2018	We found that andrographolide concentration-dependently inhibited TNF-alpha-induced IL-8 mRNA (2.23 +- 0.15 fold at 20 muM) and protein expression (4.78 +- 0.31 fold at 20 muM) and reduced the IL-8 transcriptional activity (2.59 +- 0.25 fold at 20 muM).	andrographolide	14-29	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
29672044-6	2018	We found that andrographolide concentration-dependently inhibited TNF-alpha-induced IL-8 mRNA (2.23 +- 0.15 fold at 20 muM) and protein expression (4.78 +- 0.31 fold at 20 muM) and reduced the IL-8 transcriptional activity (2.59 +- 0.25 fold at 20 muM).	andrographolide	14-29	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
29672044-12	2018	Taken together, andrographolide antagonizes TNF-alpha-induced IL-8 via inhibition of NADPH oxidase/ROS/NF-kappaB and Src/MAPKs/AP-1 signaling pathways in HCT116 colorectal cancer cells and then suppresses angiogenesis in the tumor microenvironment.	andrographolide	16-31	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
29672044-12	2018	Taken together, andrographolide antagonizes TNF-alpha-induced IL-8 via inhibition of NADPH oxidase/ROS/NF-kappaB and Src/MAPKs/AP-1 signaling pathways in HCT116 colorectal cancer cells and then suppresses angiogenesis in the tumor microenvironment.	Reactive Oxygen Species	99-102	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
29882863-1	2018	This work provides a cost-effective approach for preparing functional polymeric fibers used for removing uranium (U(VI)) from carbonate solution containing NaF.	Uranium	105-112	C-X-C motif chemokine ligand 8	Homo sapiens	156-159
29875665-12	2018	TSA showed similar effects on IL-8 production and VCAM-1 expression as butyrate and propionate.	trichostatin A	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
29882863-1	2018	This work provides a cost-effective approach for preparing functional polymeric fibers used for removing uranium (U(VI)) from carbonate solution containing NaF.	Carbonates	126-135	C-X-C motif chemokine ligand 8	Homo sapiens	156-159
29875665-14	2018	Conclusion: Activation of GPR41/43 mediates the effects of acetate on IL-6 and IL-8 production and the effects of butyrate and propionate on IL-6 production.	Acetates	59-66	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
29875665-15	2018	Furthermore, inhibition of HDACs mediates the effects of butyrate and propionate on IL-8 production, VCAM-1 expression, and PBMC adhesion to an endothelial monolayer.	Butyrates	57-65	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
32254344-7	2018	In human whole blood, CS@OVA-13 and CS@OVA-65 were phagocytosed with a significantly higher ratio by granulocytes and monocytes, leading to the higher secretion of TNF-alpha, IL-1beta and IL-8, and a larger extent of platelet activation than CS@HSA-10 and CS@HSA-57, respectively.	Chitosan	22-24	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
32254344-7	2018	In human whole blood, CS@OVA-13 and CS@OVA-65 were phagocytosed with a significantly higher ratio by granulocytes and monocytes, leading to the higher secretion of TNF-alpha, IL-1beta and IL-8, and a larger extent of platelet activation than CS@HSA-10 and CS@HSA-57, respectively.	Chitosan	36-38	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
32254344-7	2018	In human whole blood, CS@OVA-13 and CS@OVA-65 were phagocytosed with a significantly higher ratio by granulocytes and monocytes, leading to the higher secretion of TNF-alpha, IL-1beta and IL-8, and a larger extent of platelet activation than CS@HSA-10 and CS@HSA-57, respectively.	Chitosan	36-38	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
32254344-7	2018	In human whole blood, CS@OVA-13 and CS@OVA-65 were phagocytosed with a significantly higher ratio by granulocytes and monocytes, leading to the higher secretion of TNF-alpha, IL-1beta and IL-8, and a larger extent of platelet activation than CS@HSA-10 and CS@HSA-57, respectively.	Chitosan	36-38	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
29683320-4	2018	KCO-4 inhibited the oversecretion of inflammatory mediators (i.e., NO, TNF-alpha, IL-1beta, IL-8, iNOS, and COX-2).	kco-4	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
29793566-3	2018	Test group lesions were treated using resin infiltration followed by five percent topical sodium fluoride (NaF) application versus five percent NaF alone in the control group.	Sodium Fluoride	90-105	C-X-C motif chemokine ligand 8	Homo sapiens	107-110
29785126-11	2018	Suppression of TGF-beta signaling by OT-101 led to upregulation of IL-8, IL-15, IP-10, and HGF.	ot-101	37-43	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
29785126-13	2018	The mixed analysis of covariance model that examined the levels of 19 cyto-/chemokines with OS as the covariate at each of the time points resulted in IL-8 and IL-15 exhibiting a significant association with OS during Cycle 1 of therapy.	Osmium	92-94	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
29785126-14	2018	In the whole-blood culture model, the cytokines with the most pronounced increase after OT-101 treatment were IL-1beta, IL-8, and MCP-1.	ot-101	88-94	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
29785126-16	2018	Levels of IL-8 and IL-15 during Cycle 1 were positively associated with OS across 12 patients with PAC and served as potential biomarkers for treatment outcome following OT-101 therapy.	ot-101	170-176	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
29634256-2	2018	Mild hydrothermal reactions with uranyl acetate as a precursor yielded 1, 7, and the monoclinic polymorph of NaU2F9, whereas direct reactions between UF4 and NaF led to the formation of 2 and orthorhombic NaU2F9 (3).	uf4	150-153	C-X-C motif chemokine ligand 8	Homo sapiens	158-161
29634256-2	2018	Mild hydrothermal reactions with uranyl acetate as a precursor yielded 1, 7, and the monoclinic polymorph of NaU2F9, whereas direct reactions between UF4 and NaF led to the formation of 2 and orthorhombic NaU2F9 (3).	nau2f9	205-211	C-X-C motif chemokine ligand 8	Homo sapiens	158-161
29439091-8	2018	In vitro, CXL induced significant release of Gal-1 in keratocyte supernatants (116+-18 ng/mL, P&lt;0.05) and decreased inflammatory biomarkers as interleukin (IL)-6, IL-8, matrix metalloproteinase (MMP)-2 and MMP-9.	Cyclohexanols	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
29648435-5	2018	The FEC-NaFSI constructs the mechanically strong and ion-permeable interlayer containing NaF and ionic compounds such as Na2CO3 and sodium alkylcarbonates.	sodium carbonate	121-127	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
29648435-5	2018	The FEC-NaFSI constructs the mechanically strong and ion-permeable interlayer containing NaF and ionic compounds such as Na2CO3 and sodium alkylcarbonates.	sodium alkylcarbonates	132-154	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
29471239-5	2018	NaF increased expression of miR-200c-3p and miR-200c-3p inhibitor reduced activation of SaoS2 induced by NaF via targeting Noggin to repress BMP4/Smad.	saos2	88-93	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
29471239-5	2018	NaF increased expression of miR-200c-3p and miR-200c-3p inhibitor reduced activation of SaoS2 induced by NaF via targeting Noggin to repress BMP4/Smad.	saos2	88-93	C-X-C motif chemokine ligand 8	Homo sapiens	105-108
30052195-7	2018	Taurine and aloe extract significantly (p &lt; 0.05) reduced IL-lalpha and IL-8 production in vitro and in vivo after topical application of formulations containing AlCl3.	Taurine	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	61-79
29143360-10	2018	In addition, FPTHQ treatment increased the protein levels of MMP3 and the mRNA levels of IL-6 and IL-8 in A2780 cells, indicating the appearance of senescence-associated secretary phenotype (SASP) in the cells.	fpthq	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
29410518-10	2018	Furthermore, rifaximin reduced IL-8 secretion from pregnane X receptor-expressing T84 colonic epithelial cells.	Rifaximin	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
30398154-4	2018	LPS-treated HUVECs cultured in low magnesium showed up-regulation of mRNA expression for pro-inflammatory factors and the expression of cytokine proteins, including IL-2, IL-3, IL-8, IL-15 and MCP-1.	Magnesium	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
29568907-0	2018	Differential modulation by vanadium pentoxide of the secretion of CXCL8 and CXCL11 chemokines in thyroid cells.	vanadium pentoxide	27-45	C-X-C motif chemokine ligand 8	Homo sapiens	66-71
29575797-6	2018	RESULT: NTHi induced production of large amounts of IL-1beta, IL-6, and IL-8 in adult-control BAL cells, however BAL cells from PBB airways appeared refractory to NTHi stimulation.	nthi	8-12	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
29908644-12	2018	Concomitantly, LY294002 inhibited CdCl2-induced IL-8 in JEG-3 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
29908644-12	2018	Concomitantly, LY294002 inhibited CdCl2-induced IL-8 in JEG-3 cells.	Cadmium Chloride	34-39	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
29300263-8	2018	The level of proinflammatory cytokine IL-8 was elevated in BAK-treated cells.	Benzalkonium Compounds	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
30006643-10	2018	Body mass index positively correlated with 18F-FDG uptake in the soft tissue (r=0.53, P&lt;0.0001), osseous compartment (r=0.58, P&lt;0.0001) and 18F-NaF uptake in the joint (r=0.37, P=0.0001).	Fluorodeoxyglucose F18	43-50	C-X-C motif chemokine ligand 8	Homo sapiens	150-153
29243408-6	2018	RESULTS: Micronucleated cells (P &lt; .00) and MN (P &lt; .00) were higher in individuals exposed to chlorhexidine (CHX), followed by chlorine dioxide (ClO2 ), potassium nitrate (KNO3 ), and sodium fluoride (NaF), amine fluoride (AmF), and normal saline.	Chlorhexidine	101-114	C-X-C motif chemokine ligand 8	Homo sapiens	208-211
29243408-6	2018	RESULTS: Micronucleated cells (P &lt; .00) and MN (P &lt; .00) were higher in individuals exposed to chlorhexidine (CHX), followed by chlorine dioxide (ClO2 ), potassium nitrate (KNO3 ), and sodium fluoride (NaF), amine fluoride (AmF), and normal saline.	Chlorhexidine	116-119	C-X-C motif chemokine ligand 8	Homo sapiens	208-211
29550716-5	2018	The NaF treatment associated with CSE recovered the bond strength values of SD/CSE and associated with CSE demonstrated lower microTBS than other groups, although significantly higher than DD (p &lt; 0.05).	microtbs	126-134	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
29616124-4	2018	Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration.	Sodium Citrate	16-30	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
29616124-4	2018	Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration.	Sodium Citrate	169-183	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
29908644-6	2018	RESULTS: TNF-alpha, IL-8 and IL-6 mRNAs were elevated in CdCl2-treated JEG-3 cells.	Cadmium Chloride	57-62	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
29908644-8	2018	Moreover, keratinocyte chemokine (KC), a functional analogue of human IL-8, was increased in maternal serum and amniotic fluid from CdCl2-exposed mice.	Cadmium Chloride	132-137	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
29413962-5	2018	Moreover, we demonstrated that the expression of NF-kappaB, COX-2, IL-8, and MMP-13 were elevated subsequent to inhibition of SIRT1/AMPK/PGC-1alpha/PPAR-gamma pathway by homocysteine, thereby causing detrimental effects on chondrocytes.	Homocysteine	170-182	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
29413957-7	2018	2-ClHA and its alkyne analogue interfered with protein palmitoylation, induced ER-stress markers, reduced the ER ATP content, and activated transcription and secretion of interleukin (IL)-6 as well as IL-8.	2-chlorohexadecanoic acid	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	201-205
29413957-7	2018	2-ClHA and its alkyne analogue interfered with protein palmitoylation, induced ER-stress markers, reduced the ER ATP content, and activated transcription and secretion of interleukin (IL)-6 as well as IL-8.	Alkynes	15-21	C-X-C motif chemokine ligand 8	Homo sapiens	201-205
30052195-7	2018	Taurine and aloe extract significantly (p &lt; 0.05) reduced IL-lalpha and IL-8 production in vitro and in vivo after topical application of formulations containing AlCl3.	Aluminum Chloride	165-170	C-X-C motif chemokine ligand 8	Homo sapiens	61-79
29570290-3	2018	The addition of NaF as a mineralizer increases the crystallinity of gamma-zirconium phosphate, which forms micrometer-sized uniformly shaped rectangular platelets.	gamma-zirconium phosphate	68-93	C-X-C motif chemokine ligand 8	Homo sapiens	16-19
29854096-0	2018	Cafestol Inhibits Cyclic-Strain-Induced Interleukin-8, Intercellular Adhesion Molecule-1, and Monocyte Chemoattractant Protein-1 Production in Vascular Endothelial Cells.	cafestol	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
29854096-9	2018	The addition of zinc protoporphyrin IX, sirtinol, or Sirt1 silencing (transfected with Sirt1 siRNA) significantly attenuated cafestol-mediated modulatory effects on cyclic-strain-stimulated ICAM-1, MCP-1, and IL-8 secretion.	cafestol	125-133	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
29755453-7	2018	The binding of a CLEC10A-specific bivalent ligand (the MUC-1 peptide glycosylated with N-acetylgalactosamine) is limited to CD1c+ DCs and enhances the cytokine secretion (namely TNFalpha, IL-8, and IL-10) induced by TLR 7/8 stimulation.	Acetylgalactosamine	87-108	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
29922277-9	2018	Interleukin (IL)-6 and IL-8 mRNA and protein were induced in both cell types after treatment with AMC particles, whereas exposure to CoCr particles resulted in significantly upregulated IL-6 and IL-8 protein contents in PBMCs only.	7-amino-4-methylcoumarin	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
29922277-9	2018	Interleukin (IL)-6 and IL-8 mRNA and protein were induced in both cell types after treatment with AMC particles, whereas exposure to CoCr particles resulted in significantly upregulated IL-6 and IL-8 protein contents in PBMCs only.	7-amino-4-methylcoumarin	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
29850636-2	2018	Our objective was to analyze any association between the oxygen levels at blood sampling and plasma levels of the interleukins IL-6, IL-1beta, IL-10, and IL-8 and TNF-alpha in preterm newborns under mechanical ventilation (MV) in their first two days.	Oxygen	57-63	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
29850636-11	2018	In the high oxygen group, IL-6, IL-8, and TNF-alpha plasma levels increased significantly after two hours under MV.	Oxygen	12-18	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
29713062-9	2018	siRNA downregulation of 2-deoxy-D-ribose 5-phosphate (DR5P) aldolase, which is needed for DR5P to enter glycolysis, also suppressed the induction of NADPH and IL-8 in TP-expressing cells.	dr5p	54-58	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
29731195-8	2018	Cellular ROS production was increased by PM treatment, and antioxidant N-acetyl cysteine pretreatment prevented induction of inflammatory cytokines IL-8 and MMP-1.	Acetylcysteine	71-88	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
29702553-13	2018	Hydroxyethyl starch 70 kDa significantly increased the recovery of interleukin (IL)-8 in human serum in vitro when compared with Ringer&amp;rsquo;s lactate.	Hydroxyethyl starch	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	67-85
29507072-4	2018	IL-8 levels were negatively correlated with the number of ceftriaxone doses administered (r = -0.315; P = 0.031).	Ceftriaxone	58-69	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
29713468-13	2018	However, we observed that the mRNA expression of IL-8 in placenta was reduced by maternal resveratrol.	Resveratrol	90-101	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
29626212-7	2018	Co-treatment of high glucose with palmitic acid potentiated the expression of several DR-relevant angiogenic and inflammatory targets, including PTGS2 (COX-2) and CXCL8 (IL-8).	Glucose	21-28	C-X-C motif chemokine ligand 8	Homo sapiens	163-168
29518371-4	2018	The aim of this study was to elucidate the underlying mechanism of NTAPP-induced IL-8 expression in human keratinocyte HaCaT cells.	Plasma Gases	67-72	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
29518371-8	2018	High intracellular K+ concentrations suppressed NTAPP-induced IL-8 mRNA expression, and the K+ ionophore valinomycin (Val) enhanced the induction of IL-8 mRNA.	Plasma Gases	48-53	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
29518371-8	2018	High intracellular K+ concentrations suppressed NTAPP-induced IL-8 mRNA expression, and the K+ ionophore valinomycin (Val) enhanced the induction of IL-8 mRNA.	Valinomycin	105-116	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
29518371-8	2018	High intracellular K+ concentrations suppressed NTAPP-induced IL-8 mRNA expression, and the K+ ionophore valinomycin (Val) enhanced the induction of IL-8 mRNA.	Valinomycin	118-121	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
29518371-9	2018	Moreover, NTAPP stimulated activation of ERK MAP kinase and the ERK inhibitor prevented NTAPP-induced IL-8 mRNA expression.	Plasma Gases	10-15	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
29518371-9	2018	Moreover, NTAPP stimulated activation of ERK MAP kinase and the ERK inhibitor prevented NTAPP-induced IL-8 mRNA expression.	Plasma Gases	88-93	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
29268188-10	2018	Semi-quantitative detection of IL-8 consumption in HUVEC cells in low oxygen condition was also achieved.	Oxygen	70-76	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
29626212-7	2018	Co-treatment of high glucose with palmitic acid potentiated the expression of several DR-relevant angiogenic and inflammatory targets, including PTGS2 (COX-2) and CXCL8 (IL-8).	Glucose	21-28	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
29626212-7	2018	Co-treatment of high glucose with palmitic acid potentiated the expression of several DR-relevant angiogenic and inflammatory targets, including PTGS2 (COX-2) and CXCL8 (IL-8).	Palmitic Acid	34-47	C-X-C motif chemokine ligand 8	Homo sapiens	163-168
29626212-7	2018	Co-treatment of high glucose with palmitic acid potentiated the expression of several DR-relevant angiogenic and inflammatory targets, including PTGS2 (COX-2) and CXCL8 (IL-8).	Palmitic Acid	34-47	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
29293370-0	2018	Initial experience with 18F-sodium fluoride (NaF) PET-CT: a viable functional biomarker in symptomatic Os acromiale.	18f-sodium fluoride	24-43	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
29293370-4	2018	18F Sodium Fluoride (NaF) Positron Emission Tomography -CT (PET-CT) is an emerging and highly sensitive modality for oncological skeletal staging, and can show a variety of non-malignant uptake.	Sodium Fluoride	4-19	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
29293370-5	2018	We have analysed the relationship between 18F-NaF uptake in OA and associated symptoms of shoulder pain.	Fluorine-18	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
29452068-5	2018	Here, we found that glycyrrhizin (20 or 40 muM) inhibited histamine-induced the mRNA expression and secretion of mucin 5 subtype AC (MUC5AC), interleukin (IL)-6 and IL-8 in HNEpCs.	Histamine	58-67	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
29176750-3	2018	High levels of C-X-C motif chemokine ligand 8/interleukin-8 (CXCL8/IL-8), the most potent chemokine to attract neutrophils to sites of infection, are detected in the sputum of both patient groups and might cause the high neutrophil influx in the airways.	c-x-c	15-20	C-X-C motif chemokine ligand 8	Homo sapiens	61-66
29176750-3	2018	High levels of C-X-C motif chemokine ligand 8/interleukin-8 (CXCL8/IL-8), the most potent chemokine to attract neutrophils to sites of infection, are detected in the sputum of both patient groups and might cause the high neutrophil influx in the airways.	c-x-c	15-20	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
29452068-5	2018	Here, we found that glycyrrhizin (20 or 40 muM) inhibited histamine-induced the mRNA expression and secretion of mucin 5 subtype AC (MUC5AC), interleukin (IL)-6 and IL-8 in HNEpCs.	Glycyrrhizic Acid	20-32	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
29875577-9	2018	The presence of glycerol-supplemented L. reuteri significantly reduced the expression of IL-8 and hBD-2 on HaCat cells (P &lt; 0.05).	Glycerol	16-24	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
29405435-8	2018	Increased IL-8 levels, measured within 24 hours, were associated with PGD3, more ECMO use, higher donor paO2 , younger donor age, but not with other short-or long-term outcome.	pao2	104-108	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
29223613-1	2018	AIM: To investigate the usefulness of a quantitative parameter (maximum standardised uptake value [SUVmax]) of 18F-sodium fluoride (NaF) positron-emission tomography (PET)/computed tomography (CT) for the evaluation of temporomandibular joint (TMJ) disorder (TMD).	18f-sodium fluoride	111-130	C-X-C motif chemokine ligand 8	Homo sapiens	132-135
29875577-10	2018	Conclusion: Glycerol-supplemented L. reuteri reduced the expression of IL-8 and hBD-2, and the results may be proof of principle for a probiotic approach to combating inflammation.	Glycerol	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
29256007-5	2018	RESULTS: IL-1beta decreased genomic methylation of human intestinal epithelial cells and induced demethylation at cg-specific sites at the promoter of pro-inflammatory genes IL6 and IL8; conversely it did not change the methylation of the IL10 promoter.	cysteinylglycine	114-116	C-X-C motif chemokine ligand 8	Homo sapiens	182-185
29643687-3	2018	18F-sodium fluoride positron emission tomography-computed tomography (18F-NaF PET-CT) demonstrates increased radiotracer uptake at body of D4 vertebra.	18f-sodium fluoride	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
29230506-5	2018	The effect of iPA on IL-8 and RANTES secretion was determined by ELISA, and the activation and expression of signaling molecules and selenoproteins were studied by Western blot.	Isopentenyladenosine	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
29230506-7	2018	RESULTS: We demonstrated for the first time that iPA prevents IL-8 and RANTES release in TNFalpha-stimulated CF cells and this effect is mediated by increasing the expression of the direct NFkappaB inhibitor IkappaBalpha and decreasing the levels of STAT3.	Isopentenyladenosine	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
29127842-8	2018	Dynamic compliance was significantly improved in the budesonide group on days 3 (p=0.018) and 5 (p=0.011) The levels of CXCL-8 and IL-6 diminished on days 3-5 after start of budesonide (p&lt;0.05).	Budesonide	53-63	C-X-C motif chemokine ligand 8	Homo sapiens	120-126
29127842-9	2018	CONCLUSION: In COPD patients on MV, nebulized budesonide was associated with reduced BAL CXCL8 and IL-6 levels and neutrophil numbers as well as an improvement in ventilatory mechanics and facilitated weaning.	Budesonide	46-56	C-X-C motif chemokine ligand 8	Homo sapiens	89-94
29353318-9	2018	CONCLUSIONS: VEGF and IL-8 production in the pleural cavity appear to accelerate the progression of PPE to empyema, by enhancing vascular permeability associated with inflammation.	ppe	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
29380034-6	2018	In the absence of an airway insult, we expected to find no evidence of airway inflammation; however, transcripts for several asthma-associated cytokines, including IL17A, IL1A, and IL8, were elevated in the tracheas of bethanechol-treated piglets.	Bethanechol	219-230	C-X-C motif chemokine ligand 8	Homo sapiens	181-184
29614734-3	2018	A preliminary bioactive study shows that (+)-liphagal is a selective kinase (PI3K alpha) inhibitor, while (+)-frondosin B is shown to inhibit the binding of the cytokine interleukin-8 (IL-8) to its receptor, CX-CLR1/2.	liphagal	41-53	C-X-C motif chemokine ligand 8	Homo sapiens	170-183
29351123-1	2018	OBJECTIVE: Determination of the accuracy of sodium fluorine-18-fluoride (F-NaF) PET/computed tomography (CT) for the evaluation of bone metastases, and the impact on patient management in breast cancer patients.	sodium fluorine-18-fluoride	44-71	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
29166379-6	2018	In stimulated Caco-2 cells, vernix-MAG was more effective than vernix-FFA in suppressing IL-8 and NF-kappaB.	vernix-mag	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
29166379-6	2018	In stimulated Caco-2 cells, vernix-MAG was more effective than vernix-FFA in suppressing IL-8 and NF-kappaB.	vernix-ffa	63-73	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
29408666-5	2018	Acute exposure to high MPA or ROQ C concentrations induced an increase of IL-8 secretion.	roquefortine	30-35	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
29337216-0	2018	In vitro lung epithelial cell transport and anti-interleukin-8 releasing activity of liposomal ciprofloxacin.	Ciprofloxacin	95-108	C-X-C motif chemokine ligand 8	Homo sapiens	49-62
29337216-5	2018	The inhibitory activities of Lipo-CPFX and CPFX against lipopolysaccharide (LPS)-induced IL-8 release were assessed in a co-incubation or pre-incubation mode.	lipo-cpfx	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
29337216-5	2018	The inhibitory activities of Lipo-CPFX and CPFX against lipopolysaccharide (LPS)-induced IL-8 release were assessed in a co-incubation or pre-incubation mode.	Ciprofloxacin	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
29337216-8	2018	Lipo-CPFX was equipotent to CPFX in the anti-IL-8 releasing activity upon 24 h co-incubation with LPS.	lipo-cpfx	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
29337216-8	2018	Lipo-CPFX was equipotent to CPFX in the anti-IL-8 releasing activity upon 24 h co-incubation with LPS.	Ciprofloxacin	5-9	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
29337216-9	2018	Additionally, Lipo-CPFX, but not CPFX, retained the anti-IL-8 releasing activity even 24 h after pre-incubation.	lipo-cpfx	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
29436743-3	2018	Plasma eCBs and NAE profiles were correlated with self-rated oral cavity pain intensities, depressive symptomatology and plasma IL-8 levels.	ecbs	7-11	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
29436743-3	2018	Plasma eCBs and NAE profiles were correlated with self-rated oral cavity pain intensities, depressive symptomatology and plasma IL-8 levels.	N-acylethanolamines	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
29614734-3	2018	A preliminary bioactive study shows that (+)-liphagal is a selective kinase (PI3K alpha) inhibitor, while (+)-frondosin B is shown to inhibit the binding of the cytokine interleukin-8 (IL-8) to its receptor, CX-CLR1/2.	frondosin B	106-121	C-X-C motif chemokine ligand 8	Homo sapiens	170-183
29337216-9	2018	Additionally, Lipo-CPFX, but not CPFX, retained the anti-IL-8 releasing activity even 24 h after pre-incubation.	Ciprofloxacin	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
29337216-10	2018	In conclusion, Lipo-CPFX enabled slower absorptive lung epithelial cell transport and uptake of ciprofloxacin, apparently via the lipid bilayer fusion mechanism, and the sustained inhibitory activity against LPS-induced IL-8 release, compared to CPFX.	lipo-cpfx	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	220-224
29614734-3	2018	A preliminary bioactive study shows that (+)-liphagal is a selective kinase (PI3K alpha) inhibitor, while (+)-frondosin B is shown to inhibit the binding of the cytokine interleukin-8 (IL-8) to its receptor, CX-CLR1/2.	frondosin B	106-121	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
29337216-10	2018	In conclusion, Lipo-CPFX enabled slower absorptive lung epithelial cell transport and uptake of ciprofloxacin, apparently via the lipid bilayer fusion mechanism, and the sustained inhibitory activity against LPS-induced IL-8 release, compared to CPFX.	Ciprofloxacin	20-24	C-X-C motif chemokine ligand 8	Homo sapiens	220-224
29596311-6	2018	However, interleukin-8 was different between pre- and post-tests (p &lt; 0.001) in both groups (&amp;Delta; = 7.61 and 5.61 pg/mL) as were cholesterol levels (p &lt; 0.05), with no interaction between groups.	Adenosine Monophosphate	97-100	C-X-C motif chemokine ligand 8	Homo sapiens	9-22
29615908-7	2018	Acetate, butyrate and propionate reduced IL-6 and IL-8 levels and the magnitude was dependent on the incubation times.	Acetates	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
29615908-7	2018	Acetate, butyrate and propionate reduced IL-6 and IL-8 levels and the magnitude was dependent on the incubation times.	Butyrates	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
29615908-7	2018	Acetate, butyrate and propionate reduced IL-6 and IL-8 levels and the magnitude was dependent on the incubation times.	Propionates	22-32	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
29615908-12	2018	Conclusion: SCFA, including acetate, butyrate and propionate, influenced LPS- or TNFalpha-induced endothelial activation by inhibiting the production of IL-6 and IL-8, and reducing the expression of VCAM-1 and subsequent cell adhesion.	Acetates	28-35	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
29615908-12	2018	Conclusion: SCFA, including acetate, butyrate and propionate, influenced LPS- or TNFalpha-induced endothelial activation by inhibiting the production of IL-6 and IL-8, and reducing the expression of VCAM-1 and subsequent cell adhesion.	Propionates	50-60	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
29965469-6	2018	To effectively regenerate TiO2, the removal efficiency of Si polymers on TiO2 via sodium fluoride (NaF) was studied.	Silicon	58-60	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
29713361-4	2018	AGNE reduced histamine secretion, production of proinflammatory cytokines including interleukin- (IL-) 1beta, IL-4, IL-6, IL-8, and IL-10, and expression of cyclooxygenase- (COX-) 2 in HMC-1 cells.	agne	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
29306057-7	2018	In addition, compared with the placebo, omega-3 and vitamin E co-supplementation down-regulated interleukin-8 (IL-8) (P = 0.003) and tumor necrosis factor alpha (TNF-alpha) expression (P = 0.001) in PBMC of PCOS women.	Fatty Acids, Omega-3	40-47	C-X-C motif chemokine ligand 8	Homo sapiens	96-109
29306057-7	2018	In addition, compared with the placebo, omega-3 and vitamin E co-supplementation down-regulated interleukin-8 (IL-8) (P = 0.003) and tumor necrosis factor alpha (TNF-alpha) expression (P = 0.001) in PBMC of PCOS women.	Fatty Acids, Omega-3	40-47	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
29306057-7	2018	In addition, compared with the placebo, omega-3 and vitamin E co-supplementation down-regulated interleukin-8 (IL-8) (P = 0.003) and tumor necrosis factor alpha (TNF-alpha) expression (P = 0.001) in PBMC of PCOS women.	Vitamin E	52-61	C-X-C motif chemokine ligand 8	Homo sapiens	96-109
29306057-7	2018	In addition, compared with the placebo, omega-3 and vitamin E co-supplementation down-regulated interleukin-8 (IL-8) (P = 0.003) and tumor necrosis factor alpha (TNF-alpha) expression (P = 0.001) in PBMC of PCOS women.	Vitamin E	52-61	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
29306057-9	2018	CONCLUSION: Omega-3 and vitamin E co-supplementation was effective in improving parameters of mental health, and gene expression of PPAR-gamma, IL-8 and TNF-alpha of women with PCOS.	Fatty Acids, Omega-3	12-19	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
29306057-9	2018	CONCLUSION: Omega-3 and vitamin E co-supplementation was effective in improving parameters of mental health, and gene expression of PPAR-gamma, IL-8 and TNF-alpha of women with PCOS.	Vitamin E	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
29965469-6	2018	To effectively regenerate TiO2, the removal efficiency of Si polymers on TiO2 via sodium fluoride (NaF) was studied.	titanium dioxide	73-77	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
29965469-6	2018	To effectively regenerate TiO2, the removal efficiency of Si polymers on TiO2 via sodium fluoride (NaF) was studied.	Sodium Fluoride	82-97	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
29965469-7	2018	The results showed that NaF could remove Si monomer and polymer from TiO2, and the regenerated TiO2 could be reused with a stable adsorption performance.	Silicon	41-43	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
29515108-4	2018	Our studies reveal that sunitinib triggers two resistance-promoting signaling pathways in RCC cells, which emanate from the endoplasmic reticulum (ER) stress response: a PERK-driven ER stress response that induces expression of the pro-tumorigenic cytokines IL-6, IL-8, and TNF-alpha, and a TRAF2-mediated NF-kappaB survival program that protects tumor cells against cell death.	Sunitinib	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	264-268
29965469-7	2018	The results showed that NaF could remove Si monomer and polymer from TiO2, and the regenerated TiO2 could be reused with a stable adsorption performance.	titanium dioxide	69-73	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
29515108-5	2018	PERK blockade completely prevents sunitinib-induced expression of IL-6, IL-8 and TNF-alpha, whereas NF-kappaB inhibition reinstates sensitivity of RCC cells to sunitinib both in vitro and in vivo.	Sunitinib	34-43	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
29965469-7	2018	The results showed that NaF could remove Si monomer and polymer from TiO2, and the regenerated TiO2 could be reused with a stable adsorption performance.	titanium dioxide	95-99	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
29965469-8	2018	In situ ATR-FTIR spectroscopy suggested that NaF desorbed the Si monomer and polymer effectively.	Silicon	62-64	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
29965469-9	2018	When spent TiO2 was regenerated with NaOH and NaF in three treatment cycles, As and Si desorption rates were 86.8%-100.3% and 67.9%-82.0%, respectively.	titanium dioxide	11-15	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
29331857-7	2018	Baicalin alleviated IL-1beta-induced inflammatory injury, as it increased cell viability, decreased cell apoptosis and repressed the production of IL-6, IL-8 and TNF-alpha.	baicalin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
29513760-6	2018	Several inflammatory molecules upregulated by tumor necrosis factor-alpha in human retinal vascular endothelial cells were markedly reduced by metformin, including nuclear factor kappa B p65 (NFkappaB p65), intercellular adhesion molecule-1 (ICAM-1), monocyte chemotactic protein-1 (MCP-1), and interleukin-8 (IL-8).	Metformin	143-152	C-X-C motif chemokine ligand 8	Homo sapiens	295-308
29513760-6	2018	Several inflammatory molecules upregulated by tumor necrosis factor-alpha in human retinal vascular endothelial cells were markedly reduced by metformin, including nuclear factor kappa B p65 (NFkappaB p65), intercellular adhesion molecule-1 (ICAM-1), monocyte chemotactic protein-1 (MCP-1), and interleukin-8 (IL-8).	Metformin	143-152	C-X-C motif chemokine ligand 8	Homo sapiens	310-314
29692858-10	2018	Dieckol and eckol attenuated the expression of inflammatory cytokines such as tumor necrosis factor- (TNF-) alpha, interleukin- (IL-) 1beta, IL-6, and IL-8 in human epidermal keratinocytes stimulated with PM10.	dieckol	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
29155016-3	2018	In this report, we demonstrated that in vitro, DZ2002 significantly decreased the expression of pro-inflammatory cytokines and adhesion molecule including IL-1alpha, IL-1beta, IL-6, IL-8, TNF-alpha and ICAM-1 by inhibiting the phosphorylation of p38 MAPK, ERK and JNK in TNF-alpha/IFN-gamma-stimulated HaCaT human keratinocytes.	methyl 4-(adenin-9-yl)-2-hydroxybutanoate	47-53	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
29412148-6	2018	A specific inhibitor of p38MAPK, SB203580 significantly decreased the secretion of IL-6 and IL-8, the major components of SASPs.	SB 203580	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
29412148-7	2018	Additionally, treatment of senescent astrocytes with NF-kappaB inhibitor, BAY 11-7092, also suppressed the secretion of IL-6 and IL-8, suggesting NF-kappaB was required for SASP.	bay 11-7092	74-85	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
29520786-9	2018	IL-8 and monocyte chemotactic protein-1 mRNA expression could be suppressed by the vitamin D pathway.	Vitamin D	83-92	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
29450421-3	2018	The decomposition of FEC provides a NaF-containing solid electrolyte interphase with homogenous morphology and high modulus, leading to stable sodium deposition and high Coulombic efficiency (88% over 50 cycles) of the sodium metal anode.	Sodium	143-149	C-X-C motif chemokine ligand 8	Homo sapiens	36-39
29450421-3	2018	The decomposition of FEC provides a NaF-containing solid electrolyte interphase with homogenous morphology and high modulus, leading to stable sodium deposition and high Coulombic efficiency (88% over 50 cycles) of the sodium metal anode.	Sodium	219-231	C-X-C motif chemokine ligand 8	Homo sapiens	36-39
29284672-1	2018	We have previously reported that PET using 18F-fluoride (NaF PET) for assessment of osseous metastatic disease was associated with substantial changes in intended management in Medicare beneficiaries participating in the National Oncologic PET Registry (NOPR).	Fluoride ion f-18	43-55	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
29531654-9	2018	Results: Plasma TNF-alpha, IL-8, and ET-1 were significantly elevated in the BPC group than in the steady state group and the controls.	bpc	77-80	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
29486738-10	2018	IL-6, IL-8 and XIAP showed increased expressions in PTX-treated cells and this over-production effect was inhibited in TLR4-transient knockdown cells.	Paclitaxel	52-55	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
29427404-6	2018	For some experiments, human neutrophils were incubated with Reparixin (IL-8/CXCL8 receptor blocker) and then analysed as in the in vitro experiments mentioned above.	reparixin	60-69	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
29427404-6	2018	For some experiments, human neutrophils were incubated with Reparixin (IL-8/CXCL8 receptor blocker) and then analysed as in the in vitro experiments mentioned above.	reparixin	60-69	C-X-C motif chemokine ligand 8	Homo sapiens	76-81
29427404-10	2018	Reparixin inhibited human neutrophil activation by both pig and human IL-8 in a dose-dependent fashion.	reparixin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
29427404-11	2018	At 0.1 mg/mL, Reparixin inhibited the adhesion of IL-8-activated human neutrophils to pAECs by 84 +- 2.5%.	reparixin	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
29644004-6	2018	Glioblastoma stem cells (GSCs) of the mesenchymal (MES) subtype showed dramatically higher expression of IL8 when compared to proneural (PN) GSCs.	2-(N-morpholino)ethanesulfonic acid	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	105-108
29644004-7	2018	Secreted IL-8 derived from MES GSCs induced endothelial proliferation and tube formation, and the MES GBMs had increased counts of proliferating endothelial cells.	2-(N-morpholino)ethanesulfonic acid	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
29644004-7	2018	Secreted IL-8 derived from MES GSCs induced endothelial proliferation and tube formation, and the MES GBMs had increased counts of proliferating endothelial cells.	2-(N-morpholino)ethanesulfonic acid	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
29644004-8	2018	Our results highlight a critical pro-angiogenic role of IL-8 in MES GBMs.	2-(N-morpholino)ethanesulfonic acid	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
29486738-13	2018	CpdA could significantly decrease expressions of IL-6, XIAP and IL-8, as well as excreted IL-8 levels together with reduced cancer viability after PTX treatment.	CPDA	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
29486738-13	2018	CpdA could significantly decrease expressions of IL-6, XIAP and IL-8, as well as excreted IL-8 levels together with reduced cancer viability after PTX treatment.	CPDA	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
29486738-14	2018	CONCLUSIONS: The acquired TLR4-mediated PTX resistance in BCA and melanoma is explained partly by the paracrine effect of IL-6 and IL-8 released into the tumor microenvironment and over-production of anti-apoptotic protein, XIAP, in BCA cells and importantly CpdA could reduce this effect and sensitize PTX-induced apoptosis in a synergistic manner.	Paclitaxel	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
29441606-5	2018	The results showed the mRNA and protein levels of iNOS, VEGF and IL-2, IL-8 and TNF-alpha were significantly increased in PCa and BPH+HP groups compared with BPH group (p &lt; .05), while the AR was significantly lower than those in PCa and BPH+HP groups (p &lt; .05).	Hematoporphyrins	134-136	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
29407945-3	2018	Among these derivatives, 4,5-dihydropyridazinone representatives possess promising activity, selectivity towards PDE4 isoenzymes and are able to reduce IL-8 production by human primary polymorphonuclear cells.	4,5-dihydropyridazinone	25-48	C-X-C motif chemokine ligand 8	Homo sapiens	152-156
29355601-0	2018	Nickel ions bind to HSP90beta and enhance HIF-1alpha-mediated IL-8 expression.	Nickel	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
29355601-4	2018	In the present study, we compared the effects of Ni2+ and Co2+ on the expression of interleukin (IL)-8 in human monocyte THP-1 cells.	Nickel(2+)	49-53	C-X-C motif chemokine ligand 8	Homo sapiens	84-102
29355601-4	2018	In the present study, we compared the effects of Ni2+ and Co2+ on the expression of interleukin (IL)-8 in human monocyte THP-1 cells.	Cobalt(2+)	58-62	C-X-C motif chemokine ligand 8	Homo sapiens	84-102
29355601-5	2018	We report that NiCl2 but not CoCl2 induced the expression of IL-8; in contrast, CoCl2 elicited a higher expression of hypoxia-inducible factor-1alpha (HIF-1alpha).	nickel chloride	15-20	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
29355601-6	2018	The NiCl2-induced expression of IL-8 in late phase was blocked by a HIF-1alpha inhibitor, PX-478, indicating that NiCl2 targets additional factors responsible for activating HIF-1alpha.	nickel chloride	4-9	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
29355601-6	2018	The NiCl2-induced expression of IL-8 in late phase was blocked by a HIF-1alpha inhibitor, PX-478, indicating that NiCl2 targets additional factors responsible for activating HIF-1alpha.	2-amino-3-(4'-N,N-bis(2-chloroethyl)amino)phenylpropionic acid N-oxide	90-96	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
29355601-11	2018	These results suggest that HSP90beta plays important roles in Ni2+-induced production of IL-8 and could be a potential target for the regulation of Ni2+-induced inflammation.	Nickel(2+)	62-66	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
29355601-11	2018	These results suggest that HSP90beta plays important roles in Ni2+-induced production of IL-8 and could be a potential target for the regulation of Ni2+-induced inflammation.	Nickel(2+)	148-152	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
29670468-8	2018	Results: SAA-stimulated levels of released IL-6, IL-8, and sVCAM-1 from HCAEC were significantly attenuated by methotrexate, fluvastatin, and etoricoxib.	Methotrexate	111-123	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
29444128-7	2018	Regardless of the type of keratinocyte stimulation used, reduction of cytokine IL-8, IL-20 and CCL2 production (both at RNA and protein level) following genistein treatment was visible.	Genistein	153-162	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
29670468-8	2018	Results: SAA-stimulated levels of released IL-6, IL-8, and sVCAM-1 from HCAEC were significantly attenuated by methotrexate, fluvastatin, and etoricoxib.	Fluvastatin	125-136	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
29670468-8	2018	Results: SAA-stimulated levels of released IL-6, IL-8, and sVCAM-1 from HCAEC were significantly attenuated by methotrexate, fluvastatin, and etoricoxib.	Etoricoxib	142-152	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
29670468-12	2018	Methotrexate showed strong beneficial effects for lowering released Il-6, IL-8, and sVCAM-1.	Methotrexate	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
29393918-6	2018	Pro-inflammatory cytokine expression, including IL-1beta, IL-8, and IL-10, is known to be modulated by TGR5, and was dependent on NP composition, with LCA-modified cores downregulating inflammation.	Lithocholic Acid	151-154	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
29440746-6	2018	Furthermore, ZnCl2 inhibited Ni2+-induced IL-8 production, correlating with the inhibition of Ni2+ uptake.	zinc chloride	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
29440746-6	2018	Furthermore, ZnCl2 inhibited Ni2+-induced IL-8 production, correlating with the inhibition of Ni2+ uptake.	Nickel(2+)	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
29440746-6	2018	Furthermore, ZnCl2 inhibited Ni2+-induced IL-8 production, correlating with the inhibition of Ni2+ uptake.	Nickel(2+)	94-98	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
29440746-7	2018	These results suggested that Ni2+ uptake occurred through Zn2+, Mn2+, and Co2+-sensitive transporters and that the inhibition of Ni2+ uptake resulted in the inhibition of IL-8 production.	Nickel(2+)	129-133	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
29205563-4	2018	Exceptionally, by addition of 1 % NaF to a suspension of the foldamer in H2 O/THF (95:5), the fluorescence quenching efficiency by TNT vapor significantly increased from about 20 % to more than 90 %.	Water	73-77	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
29205563-4	2018	Exceptionally, by addition of 1 % NaF to a suspension of the foldamer in H2 O/THF (95:5), the fluorescence quenching efficiency by TNT vapor significantly increased from about 20 % to more than 90 %.	tetrahydrofuran	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
29440746-4	2018	In the present study, we investigated the effects of various divalent cations on Ni2+ uptake and Ni2+-induced interleukin (IL)-8 production in the human monocytic cell line, THP-1.	Nickel(2+)	97-101	C-X-C motif chemokine ligand 8	Homo sapiens	110-128
29406857-1	2018	BACKGROUND: Fluorine-18-sodium fluoride (18F-NaF) uptake is a marker of active vascular calcification associated with high-risk atherosclerotic plaque.	fluorine-18-sodium fluoride	12-39	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
29246853-0	2018	Cafestol, a coffee diterpene, inhibits urotensin II-induced interleukin-8 expression in human umbilical vein endothelial cells.	cafestol	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	60-73
29246853-0	2018	Cafestol, a coffee diterpene, inhibits urotensin II-induced interleukin-8 expression in human umbilical vein endothelial cells.	Diterpenes	19-28	C-X-C motif chemokine ligand 8	Homo sapiens	60-73
29246853-8	2018	Moreover, cafestol inhibited expression of urotensin II-induced interleukin-8.	cafestol	10-18	C-X-C motif chemokine ligand 8	Homo sapiens	64-77
29246853-9	2018	Cafestol"s inhibitory effects on interleukin-8 expression and cellular proliferation induced by urotensin II were significantly abrogated by heme oxygenase-1 silencing, suggesting it may be involved in mediating the effects of cafestol.	cafestol	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	33-46
29246853-10	2018	This study reports that cafestol inhibits urotensin II-induced interleukin-8 expression and cell proliferation via Nrf2/heme oxygenase-1-dependent mechanism in endothelial cells.	cafestol	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
29402921-4	2018	Piglets fed the lysine-restricted diet exhibited overexpression of interleukin-8 (IL-8) in the kidney (P &lt; 0.05) and IL-6 and IL-4 in the spleen (P &lt; 0.05).	Lysine	16-22	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
29402921-4	2018	Piglets fed the lysine-restricted diet exhibited overexpression of interleukin-8 (IL-8) in the kidney (P &lt; 0.05) and IL-6 and IL-4 in the spleen (P &lt; 0.05).	Lysine	16-22	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
29100748-2	2018	This study aimed to explore the roles of endoplasmic reticulum (ER) stress and autophagy in sodium fluoride (NaF)-induced neurotoxicity, focusing on the regulating role of ER stress in autophagy.	Sodium Fluoride	92-107	C-X-C motif chemokine ligand 8	Homo sapiens	109-112
29245047-0	2018	Polyriboinosinic-polyribocytidylic acid facilitates interleukin-6, and interleukin-8 secretion in human dermal fibroblasts via the JAK/STAT3 and p38 MAPK signal transduction pathways.	Poly I-C	0-39	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
29245047-3	2018	Here, we found that polyI:C enhances IL-6 and IL-8 mRNA expression and induces of IL-6 and IL-8 production in a concentration-dependent and time-dependent manner in HDFs.	Poly I-C	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
29245047-3	2018	Here, we found that polyI:C enhances IL-6 and IL-8 mRNA expression and induces of IL-6 and IL-8 production in a concentration-dependent and time-dependent manner in HDFs.	Poly I-C	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
29245047-5	2018	Moreover, pretreatment with AG490, a Janus kinase (JAK) inhibitor, inhibited polyI:C-induced STAT3 phosphorylation and subsequent IL-6 and IL-8 release.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	28-33	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
29245047-5	2018	Moreover, pretreatment with AG490, a Janus kinase (JAK) inhibitor, inhibited polyI:C-induced STAT3 phosphorylation and subsequent IL-6 and IL-8 release.	Poly I-C	77-84	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
29366441-7	2018	Furthermore, hypoxia-induced inflammation by HMGB1 translocation into the cytoplasm results in the release of IL-8 through a ROS-dependent mechanism in upper airway epithelium.	ros	125-128	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
29245047-6	2018	Conversely, pretreatment with SB203580, a selective inhibitor of p38 MAPK, blocked p38 MAPK phosphorylation and IL-6 and IL-8 expression.	SB 203580	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
29245047-7	2018	In conclusion, polyI:C induces IL-6 and IL-8 production in HDFs via the JAK/STAT3 and p38 MAPK signaling pathways.	Poly I-C	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
29100748-6	2018	Notably, inhibition of autophagy in NaF-treated SH-SY5Y cells with Wortmannin or Chloroquine decreased, while induction of autophagy by Rapamycin increased the cell viability.	Wortmannin	67-77	C-X-C motif chemokine ligand 8	Homo sapiens	36-39
29100748-6	2018	Notably, inhibition of autophagy in NaF-treated SH-SY5Y cells with Wortmannin or Chloroquine decreased, while induction of autophagy by Rapamycin increased the cell viability.	Chloroquine	81-92	C-X-C motif chemokine ligand 8	Homo sapiens	36-39
29100748-6	2018	Notably, inhibition of autophagy in NaF-treated SH-SY5Y cells with Wortmannin or Chloroquine decreased, while induction of autophagy by Rapamycin increased the cell viability.	Sirolimus	136-145	C-X-C motif chemokine ligand 8	Homo sapiens	36-39
29100748-8	2018	Importantly, mitigation of ER stress by 4-phenylbutyrate in NaF-treated SH-SY5Y cells inhibited the expressions of autophagy markers, and decreased cell apoptosis.	4-phenylbutyric acid	40-56	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
31938199-6	2018	Co-immunoprecipitation (co-IP) was used for identifying interaction of CXCL1 and CXCL8 with CXCR2 in GC cells.	12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	81-86
29331734-4	2018	AgNP alone induced dose-related IL-8 production in all models, with higher response observed in THP-1 cells, possibly connected to different protein corona formation in bovine versus human serum.	agnp	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
29331734-5	2018	AgNP potentiated LPS-induced IL-8 and TNF-alpha, but not LPS-induced IL-10.	agnp	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
29434821-6	2018	Preconditioning with physiological 5% CS for 30, 60 and 120 min was demonstrated to significantly attenuate the release of pathologically mechanical stretch-induced early pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-8) in alveolar epithelial cells (P&lt;0.05) and significantly reduce the expression of NF-kappaB (P&lt;0.05).	Cesium	38-40	C-X-C motif chemokine ligand 8	Homo sapiens	223-227
29434821-8	2018	In the second set of experiments, it was demonstrated that mechanical stretch-induced release of TNF-alpha, IL-1beta and IL-8 was significantly inhibited by both PDTC pretreatment and 5% CS pretreatment alone (all P&lt;0.05).	Cesium	187-189	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
29236553-5	2018	lipopolysaccharide co-treatment with progesterone significantly decreased the bacterial endotoxin-induced IL-1beta, TNF-alpha, IL-6, IL-8, and MIP-1alpha secretion.	Progesterone	37-49	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
29191392-7	2018	RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts.	cap	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
29415357-3	2018	A urinary IL-8 level of less than 61.25 pg/mL was more sensitive for prediction of CR in IMN patients.	Chromium	83-85	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
28600879-10	2018	After N-acetyl cysteine treatment ROS level was partly abolished providing additional enhancement of IL-6 and suppression of IL-8 and VEGF production.	Acetylcysteine	6-23	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
28600879-10	2018	After N-acetyl cysteine treatment ROS level was partly abolished providing additional enhancement of IL-6 and suppression of IL-8 and VEGF production.	ros	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
29191392-7	2018	RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts.	cap	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	145-150
29207110-0	2018	Acetylshikonin suppresses invasion of Porphyromonas gingivalis-infected YD10B oral cancer cells by modulating the interleukin-8/matrix metalloproteinase axis.	acetylshikonin	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	114-127
28801702-7	2018	Then we curiously studied whether the aging MRC-5 cell-conditioned medium could induce EMT in premalignant HaCaT cells, and the results showed that paeonol significantly reduced the clonogenic, migratory, and invasive capacities of premalignant HaCaT cells potentially induced by IL-6 and IL-8.	paeonol	148-155	C-X-C motif chemokine ligand 8	Homo sapiens	289-293
29388547-11	2018	Ruxolitinib caused a significant increase in the production of IL-6, IL-8 and TNF-alpha in stimulated cells.	ruxolitinib	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
28941582-4	2018	Topical application of the strong contact sensitizer 2,4-dinitrochlorobenzene (DNCB) induced IL-6 and IL-8 secretion in RHS with LC-like cells, whereas no change was observed in reference models.	Dinitrochlorobenzene	53-77	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
28941582-4	2018	Topical application of the strong contact sensitizer 2,4-dinitrochlorobenzene (DNCB) induced IL-6 and IL-8 secretion in RHS with LC-like cells, whereas no change was observed in reference models.	Dinitrochlorobenzene	79-83	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
28947239-5	2018	In the ALI setup, all three aldehydes caused increased secretion of IL-8, acrolein and crotonaldehyde also increased the gene expression of inflammatory and oxidative stress markers.	Aldehydes	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
29113965-8	2018	The increased mitochondrial reactive oxygen species levels of atherosclerotic-MSCs promoted a phenotypic switch characterized by enhanced glycolysis and an altered cytokine secretion (interleukin-6 P&lt;0.0001, interleukin-8/C-X-C motif chemokine ligand 8 P=0.04, and monocyte chemoattractant protein-1/chemokine ligand 2 P=0.01).	Reactive Oxygen Species	28-51	C-X-C motif chemokine ligand 8	Homo sapiens	225-255
29441020-4	2018	The elevated levels of IL-6, CRP, IL-8, and TNF-alpha were effectively reduced by EDT treatment.	eriodictyol	82-85	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
29374001-1	2018	BACKGROUND: Titanium tetrafluoride (TiF4) has regained interest due to new formulations that have been shown to be more effective against tooth demineralization than sodium fluoride (NaF) formulations in vitro and in situ.	Sodium Fluoride	166-181	C-X-C motif chemokine ligand 8	Homo sapiens	183-186
29373608-8	2018	Moreover, IL-33-induced IL-8 mRNA and secretion were also suppressed by SP600125.	pyrazolanthrone	72-80	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
29497482-12	2017	In MCF-7 cells, interleukin-8, angiogenin and vascular endothelial growth factor secretion was significantly increased by high fractional oxygen.	Oxygen	138-144	C-X-C motif chemokine ligand 8	Homo sapiens	16-29
29350745-0	2018	TiO2 nanoparticles can selectively bind CXCL8 impacting on neutrophil chemotaxis.	titanium dioxide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	40-45
29113965-9	2018	Furthermore, treatment of atherosclerotic-MSCs with the reactive oxygen species scavenger N-acetyl-l-cysteine reduced the levels of interleukin-6, interleukin-8/C-X-C motif chemokine ligand 8, and monocyte chemoattractant protein-1/chemokine ligand 2 in the MSC secretome and improved MSCs immunosuppressive capacity (P=0.03).	Reactive Oxygen Species	56-79	C-X-C motif chemokine ligand 8	Homo sapiens	147-160
29350745-3	2018	TiO2 NPs were shown to bind to CXCL8 in vitro, causing perturbation of quantification of CXCL8 by ELISA, in both simple and complex protein panels, in a dose-dependent manner.	titanium dioxide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	31-36
29350745-3	2018	TiO2 NPs were shown to bind to CXCL8 in vitro, causing perturbation of quantification of CXCL8 by ELISA, in both simple and complex protein panels, in a dose-dependent manner.	titanium dioxide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	89-94
29350745-4	2018	Binding between TiO2 NPs and CXCL8 was demonstrated by protein gel electrophoresis.	titanium dioxide	16-20	C-X-C motif chemokine ligand 8	Homo sapiens	29-34
29113965-9	2018	Furthermore, treatment of atherosclerotic-MSCs with the reactive oxygen species scavenger N-acetyl-l-cysteine reduced the levels of interleukin-6, interleukin-8/C-X-C motif chemokine ligand 8, and monocyte chemoattractant protein-1/chemokine ligand 2 in the MSC secretome and improved MSCs immunosuppressive capacity (P=0.03).	Reactive Oxygen Species	56-79	C-X-C motif chemokine ligand 8	Homo sapiens	161-191
29350745-5	2018	TiO2 NPs were also shown to inactivate the chemoattractant property of CXCL8 in a dose-dependent manner, suggesting that the binding between TiO2 NPs and CXCL8 is likely to be clinically relevant.	titanium dioxide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	71-76
29350745-5	2018	TiO2 NPs were also shown to inactivate the chemoattractant property of CXCL8 in a dose-dependent manner, suggesting that the binding between TiO2 NPs and CXCL8 is likely to be clinically relevant.	titanium dioxide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	154-159
29113965-9	2018	Furthermore, treatment of atherosclerotic-MSCs with the reactive oxygen species scavenger N-acetyl-l-cysteine reduced the levels of interleukin-6, interleukin-8/C-X-C motif chemokine ligand 8, and monocyte chemoattractant protein-1/chemokine ligand 2 in the MSC secretome and improved MSCs immunosuppressive capacity (P=0.03).	Acetylcysteine	90-109	C-X-C motif chemokine ligand 8	Homo sapiens	147-160
29350745-5	2018	TiO2 NPs were also shown to inactivate the chemoattractant property of CXCL8 in a dose-dependent manner, suggesting that the binding between TiO2 NPs and CXCL8 is likely to be clinically relevant.	titanium dioxide	141-145	C-X-C motif chemokine ligand 8	Homo sapiens	71-76
29350745-5	2018	TiO2 NPs were also shown to inactivate the chemoattractant property of CXCL8 in a dose-dependent manner, suggesting that the binding between TiO2 NPs and CXCL8 is likely to be clinically relevant.	titanium dioxide	141-145	C-X-C motif chemokine ligand 8	Homo sapiens	154-159
29350745-6	2018	The results of this study disputed the applicability of detection of CXCL8 by ELISA in systems where TiO2 NPs were present.	titanium dioxide	101-105	C-X-C motif chemokine ligand 8	Homo sapiens	69-74
29113965-9	2018	Furthermore, treatment of atherosclerotic-MSCs with the reactive oxygen species scavenger N-acetyl-l-cysteine reduced the levels of interleukin-6, interleukin-8/C-X-C motif chemokine ligand 8, and monocyte chemoattractant protein-1/chemokine ligand 2 in the MSC secretome and improved MSCs immunosuppressive capacity (P=0.03).	Acetylcysteine	90-109	C-X-C motif chemokine ligand 8	Homo sapiens	161-191
29350745-7	2018	Clinically, the disruption of chemotaxis of neutrophils in response to CXCL8 in the presence of TiO2 might mean a hampered immune response to inflammation in tissues containing TiO2 NPs.	titanium dioxide	96-100	C-X-C motif chemokine ligand 8	Homo sapiens	71-76
29895165-6	2018	In addition, at a concentration of 25 and 50 mumol/l Kaempferol could significantly reduce the expression of inflammatory mediators such as tumor necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8) and macrophage inflammatory protein 1 alpha (MIP-1alpha) in human promonocytic U937 cells-derived macrophages (dU937) in response to lipopolysaccharides (LPS) stimulation.	kaempferol	53-63	C-X-C motif chemokine ligand 8	Homo sapiens	181-194
29350745-7	2018	Clinically, the disruption of chemotaxis of neutrophils in response to CXCL8 in the presence of TiO2 might mean a hampered immune response to inflammation in tissues containing TiO2 NPs.	titanium dioxide	177-181	C-X-C motif chemokine ligand 8	Homo sapiens	71-76
29269075-6	2018	Monocytes treated with Docetaxel also displayed an elevated secretion of IL-8 and IL-1beta, but did not promote generation of monocytic myeloid-derived suppressor cells.	Docetaxel	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
29321495-5	2018	Moreover, treatment with STS (10 mug/ml) reduced CS extract (CSE)-induced IL-6 and IL-8 secretion in human bronchial epithelial (16HBE) cells.	Cesium	49-51	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
29068113-2	2018	Experiments with NaF, NaCl, NaBr, and NaI salts indicate that the Raman shifts of the Au-X- SERS bands correlate with the bond strength of the corresponding covalent interaction.	au-x-	86-91	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
29068113-2	2018	Experiments with NaF, NaCl, NaBr, and NaI salts indicate that the Raman shifts of the Au-X- SERS bands correlate with the bond strength of the corresponding covalent interaction.	sers	92-96	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
28962868-9	2018	HaCaT cells pretreated/treated with FITOPROT also showed normal expression of TNF-R1 and NF-kappaB inflammatory proteins and decreased levels of pro-inflammatory cytokines (TNF, IL-1beta, IL-6 and IL-8).	fitoprot	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
29321495-5	2018	Moreover, treatment with STS (10 mug/ml) reduced CS extract (CSE)-induced IL-6 and IL-8 secretion in human bronchial epithelial (16HBE) cells.	tanshinone II A sodium sulfonate	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
29478513-2	2018	Although glycolysis inhibitors such as sodium fluoride (NaF) in combination with potassium oxalate (KOx) are currently used for overcoming this drawback, their efficacy for stabilizing blood glucose is seemingly limited, and probably lower than that of newer additives such as the citrate buffer.	Sodium Fluoride	39-54	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
29478513-2	2018	Although glycolysis inhibitors such as sodium fluoride (NaF) in combination with potassium oxalate (KOx) are currently used for overcoming this drawback, their efficacy for stabilizing blood glucose is seemingly limited, and probably lower than that of newer additives such as the citrate buffer.	Glucose	191-198	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
29478513-2	2018	Although glycolysis inhibitors such as sodium fluoride (NaF) in combination with potassium oxalate (KOx) are currently used for overcoming this drawback, their efficacy for stabilizing blood glucose is seemingly limited, and probably lower than that of newer additives such as the citrate buffer.	Citric Acid	281-288	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
29895165-6	2018	In addition, at a concentration of 25 and 50 mumol/l Kaempferol could significantly reduce the expression of inflammatory mediators such as tumor necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8) and macrophage inflammatory protein 1 alpha (MIP-1alpha) in human promonocytic U937 cells-derived macrophages (dU937) in response to lipopolysaccharides (LPS) stimulation.	kaempferol	53-63	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
29856363-9	2018	In addition, alanine aminotransferase elevation during PEG-IFN therapy and lower serum interleukin-8 level at the end of PEG-IFN treatment were also significantly associated with HBsAg reduction by 1 year after PEG-IFN treatment (P=0.038, P=0.044, respectively).	peg-ifn	121-128	C-X-C motif chemokine ligand 8	Homo sapiens	87-100
29162452-5	2018	Enzyme-linked immunosorbent assay (ELISA) results demonstrated that DT-13 could suppress the TNF-alpha-induced upregulation of reactive oxygen species (ROS), tumor necrosis factor receptor (TNFR), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and nitric oxide in vivo dose-dependently and suppressed production of nitric oxide in vitro as shown by DAF-FMDA.	DT-13	68-73	C-X-C motif chemokine ligand 8	Homo sapiens	197-210
29162452-7	2018	Taken together, we speculate that DT-13 inhibits endothelium vascular inflammation through regulating nitric oxide production and the expression of ROS, TNFR, IL-8, MCP-1, which are associated with inflammation.	DT-13	34-39	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
29162452-5	2018	Enzyme-linked immunosorbent assay (ELISA) results demonstrated that DT-13 could suppress the TNF-alpha-induced upregulation of reactive oxygen species (ROS), tumor necrosis factor receptor (TNFR), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and nitric oxide in vivo dose-dependently and suppressed production of nitric oxide in vitro as shown by DAF-FMDA.	DT-13	68-73	C-X-C motif chemokine ligand 8	Homo sapiens	212-216
29923797-9	2018	Tumors previously exposed to niraparib had activated the ERK1/2 and AKT-mTOR pathways that correlated with increased plasma levels of IL-8, MIF, EGF, uPA and IL-12.	niraparib	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
29121426-9	2018	Immunohistochemistry revealed that xanthohumol inhibited Ki-67 expression, CD31-positive microvessel density, NF-kappaB p65 expression, and VEGF and IL-8 levels.	xanthohumol	35-46	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
30024813-13	2018	This finding argues that IL-8/ERK/AKT signaling may be an evolutionary survival response to [SRA737 + niraparib].	SRA737	93-99	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
30024813-13	2018	This finding argues that IL-8/ERK/AKT signaling may be an evolutionary survival response to [SRA737 + niraparib].	niraparib	102-111	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
29900007-9	2018	A differential inflammatory/matrix signature emerged in anthracycline induced cardiomyopathy patients compared to normal including increased interleukin-8 and MMP levels.	Anthracyclines	56-69	C-X-C motif chemokine ligand 8	Homo sapiens	141-154
29614502-8	2018	Salivary fluoride levels at 4, 6, and 26 h decreased at each time point and were generally significantly higher for 5% NaF and 5% NaF + TCP.	Fluorides	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	119-122
29614502-8	2018	Salivary fluoride levels at 4, 6, and 26 h decreased at each time point and were generally significantly higher for 5% NaF and 5% NaF + TCP.	Fluorides	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	130-133
29614502-0	2018	Fluoride Levels in Unstimulated Whole Saliva following Clinical Application of Different 5% NaF Varnishes.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
29614502-1	2018	The aim of this study was to evaluate the fluoride release from differently formulated 5% NaF varnishes into unstimulated whole saliva in vivo.	Fluorides	42-50	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
29782597-14	2018	Moreover PET/CT is performed in 1.5 h while Bone SPECT requires at least 3.5 h. Conclusions: The 18F-Fluoride PET/CT procedure could be performed with 2.9 MBq/Kg (minimum 185 MBq, recommended at least 200 MBq) of 18F-NaF to minimize the effective radiation dose received, maintaining the quality of the scan.	Fluoride ion f-18	97-109	C-X-C motif chemokine ligand 8	Homo sapiens	217-220
30308495-1	2018	BACKGROUND/AIMS: We investigated the combined toxic effect of sodium fluoride (NaF) and sulfur dioxide (SO2) on kidney morphological changes and DNA damage in male Wistar rats.	Sodium Fluoride	62-77	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
29723847-8	2018	LPS treatment dose-dependently increased the pro-inflammatory cytokine, such as interleukin (IL)-8, whereas EGCG significantly reduced the LPS-stimulated IL-8 production.	epigallocatechin gallate	108-112	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
29723847-10	2018	In particular, in the result from an RNA interference-mediated assay, our finding showed that silencing of Tollip resulted in abrogation of the inhibitory action of EGCG on LPS-induced production of pro-inflammatory mediators (inducible nitric oxide synthase-mediated NO/COX2, and IL-8) and activation of MAPKs and NF-kappaB signaling pathways.	epigallocatechin gallate	165-169	C-X-C motif chemokine ligand 8	Homo sapiens	281-285
30513523-10	2018	MiR-15 mimics induced nuclear translocation of NF-kappaB p65 and upregulated the expression of IL-8 and IFN-gamma in colonic epithelial cells; these effects were reversed by an miR-15 inhibitor.	mir-15	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
30513523-10	2018	MiR-15 mimics induced nuclear translocation of NF-kappaB p65 and upregulated the expression of IL-8 and IFN-gamma in colonic epithelial cells; these effects were reversed by an miR-15 inhibitor.	mir-15	177-183	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
28984080-5	2018	Our results demonstrated that the expression level of interleukin (IL)-6 and IL-8 were decreased after exposure of GMI and the myofibroblast activities, including collagen gel contraction, migration, invasion, and wound healing abilities were inhibited as well.	misonidazole-glutathione conjugate	115-118	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
29030692-8	2018	IL-8 was significantly increased in the IVBe + STTA group (p = 0.003) but the changes in the VEGF levels were smaller than in the IVBe group (p = 0.025).	3-Buten-2-one, 1,1,1-trifluoro-4-mercapto-4-(2-thienyl)-	47-51	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
29030692-9	2018	CONCLUSION: Intravitreal bevacizumab and subtenon triamcinolone injection reduces the VEGF, MCP-1 and PDGF-AA levels and increases the IL-8 level in the plural cytokine profiles of patients with DME, which might explain the limited therapeutic effect of combination therapy.	Triamcinolone	50-63	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
29030692-9	2018	CONCLUSION: Intravitreal bevacizumab and subtenon triamcinolone injection reduces the VEGF, MCP-1 and PDGF-AA levels and increases the IL-8 level in the plural cytokine profiles of patients with DME, which might explain the limited therapeutic effect of combination therapy.	dme	195-198	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
29649811-11	2018	Moreover, budesonide decreased CDK9 phosphorylation and markedly inhibited IL-17F-induced IL-8 production.	Budesonide	10-20	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
28113517-7	2018	Applying 1H-15N Heteronuclear Single Quantum Coherence NMR measurements, we determined the putative regions at IL-8 that are potentially responsible for interactions with the pepsin.	Hydrogen	9-11	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
28113517-7	2018	Applying 1H-15N Heteronuclear Single Quantum Coherence NMR measurements, we determined the putative regions at IL-8 that are potentially responsible for interactions with the pepsin.	15n	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
29398016-15	2018	The allergens (Der p2 and Der p3)-induced IL-6/IL-8 expression and NCA released from Beas-2B could be downregulated by dexamethasone and transcription factor inhibitor SP600125.	Dexamethasone	119-132	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
29398016-15	2018	The allergens (Der p2 and Der p3)-induced IL-6/IL-8 expression and NCA released from Beas-2B could be downregulated by dexamethasone and transcription factor inhibitor SP600125.	pyrazolanthrone	168-176	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
29193173-4	2018	Further, LSCM can image sodium fluorescein (NaF) fluorescence with 488 nm excitation (fluorescence confocal microcopy (FCM)), a small hydrophilic test molecule (370 MW, log P -1.52), which may simulate uptake, bio-distribution and kinetics of small hydrophilic drugs.	Fluorescein	24-42	C-X-C motif chemokine ligand 8	Homo sapiens	44-47
29482476-6	2018	In addition, PFDA and PFUnA enhanced gene expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 by activation of nuclear factor-kappaB in IgE-stimulated mast cells.	perfluorodecanoic acid	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
30518712-2	2018	However, our previous study suggested the superiority of the modified IL-8 Luc assay (mIL-8 Luc), in which X-VIVOTM 15 is used to dissolve chemicals, over the original assay using DMSO (oIL-8 Luc).	x-vivotm 15	107-118	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
29175450-6	2018	HCh-3 and LY294002 (alone or in combination) as well as Tiotropium (Spiriva ) or Olodaterol (alone or in combination) all reduced the levels of pPEBP1, pbeta2AR, pERK1/2, ROS, NOX-4, and IL-8 in 16HBE LECSE compared to untreated cells.	hch-3	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
29175450-6	2018	HCh-3 and LY294002 (alone or in combination) as well as Tiotropium (Spiriva ) or Olodaterol (alone or in combination) all reduced the levels of pPEBP1, pbeta2AR, pERK1/2, ROS, NOX-4, and IL-8 in 16HBE LECSE compared to untreated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
29175450-6	2018	HCh-3 and LY294002 (alone or in combination) as well as Tiotropium (Spiriva ) or Olodaterol (alone or in combination) all reduced the levels of pPEBP1, pbeta2AR, pERK1/2, ROS, NOX-4, and IL-8 in 16HBE LECSE compared to untreated cells.	Tiotropium Bromide	56-66	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
28439952-10	2018	Higher levels of IL-6, IL-8 and TNF-alpha were found in cell supernatant after stimulation with multimethacrylate (Real Seal) compared to all other sealers tested (P &lt; 0.05).	multimethacrylate	96-113	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
29439331-9	2018	Higher CSF sAbetaPPbeta levels were associated with higher plasma markers only (IL-8; MCP-1).	sabetappbeta	11-23	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
27818276-3	2018	Recent evidence shows that vitamin D acts to maintain the integrity of the gut mucosal barrier by enhancement of intercellular junctions that control mucosal permeability and reduction of pro-inflammatory cytokines such as IL-8.	Vitamin D	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	223-227
28920187-6	2018	Five percent NaF varnish was used as fluoride preparate.	fluoride preparate	37-55	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
29175450-6	2018	HCh-3 and LY294002 (alone or in combination) as well as Tiotropium (Spiriva ) or Olodaterol (alone or in combination) all reduced the levels of pPEBP1, pbeta2AR, pERK1/2, ROS, NOX-4, and IL-8 in 16HBE LECSE compared to untreated cells.	Tiotropium Bromide	68-75	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
29193173-4	2018	Further, LSCM can image sodium fluorescein (NaF) fluorescence with 488 nm excitation (fluorescence confocal microcopy (FCM)), a small hydrophilic test molecule (370 MW, log P -1.52), which may simulate uptake, bio-distribution and kinetics of small hydrophilic drugs.	Fosfomycin	119-122	C-X-C motif chemokine ligand 8	Homo sapiens	44-47
29145158-6	2018	rOmpU-induced IL-8 expression was inhibited by interference of lipid raft formation with nystatin, but not by blocking the formation of clathrin-coated pits with chlorpromazine.	Nystatin	89-97	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
29175450-6	2018	HCh-3 and LY294002 (alone or in combination) as well as Tiotropium (Spiriva ) or Olodaterol (alone or in combination) all reduced the levels of pPEBP1, pbeta2AR, pERK1/2, ROS, NOX-4, and IL-8 in 16HBE LECSE compared to untreated cells.	olodaterol	81-91	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
29859938-9	2018	TvSP-induced migration, ROS generation, CD63 expression and IL-8 release were significantly suppressed by pretreatment with OGT inhibitor ST045849 or OGT siRNA.	tvsp	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
29145158-3	2018	In this study, we evaluated the role of OmpU in induction of IL-8, a representative chemokine that recruits various inflammatory immune cells, in the human intestinal epithelial cell (IEC) line, HT-29.	ompu	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
29145158-7	2018	In addition, rOmpU-induced IL-8 expression was mediated via ERK1/2 and p38 kinase pathways, but not via JNK signaling pathway.	rompu	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
29051319-7	2018	When LoVo-P and HT29-C cells were cocultured with TAMs, CCL26 binding to the CCR3 receptor enhanced the invasiveness of LoVo-P and HT29-C cells by mobilizing intracellular Ca2+of TAMs to increase the expression of IL6 and IL8.	Tamoxifen	50-54	C-X-C motif chemokine ligand 8	Homo sapiens	222-225
29051319-7	2018	When LoVo-P and HT29-C cells were cocultured with TAMs, CCL26 binding to the CCR3 receptor enhanced the invasiveness of LoVo-P and HT29-C cells by mobilizing intracellular Ca2+of TAMs to increase the expression of IL6 and IL8.	lovo-p	5-11	C-X-C motif chemokine ligand 8	Homo sapiens	222-225
29258450-10	2017	Patients who survived more than 2 years after sorafenib treatment exhibited higher serum levels of IL-10, IL-12, TNF-a, IL-8, SDF-1, EGF, PDGF-BB, SCF, and TGF-alpha.	Sorafenib	46-55	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
29115434-7	2018	The addition of n-butanol extract from Folium isatidis inhibited this LPS-induced downregulation of CXCR1, CXCR2 and CD62L, and decreased the expression of IL-8 on neutrophils.	1-Butanol	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
29115448-8	2018	BDCM inhibited the inflammation-triggered production of cytokines including interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-alpha.	bromodichloromethane	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
29115448-12	2018	In conclusion, BDCM suppresses the expression of TNF-alpha, IL-8, and IL-6 by inhibiting the NF-kappaB and mitogen activated protein kinase signaling pathways.	bromodichloromethane	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
29055264-7	2018	Venlafaxine treatment caused greater decreases in the levels of interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), interleukin 4 (IL-4), IL-5, IL-1beta, and IL-8 than did paroxetine.	Venlafaxine Hydrochloride	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
29375548-9	2017	Finally, we demonstrate that increased mitochondrial ROS enhanced phosphorylation of ERK1/2, and induced production of IL8, findings that correlate with previous observations of increased MAPK activation and inflammatory cytokine production in CGD cells.	Reactive Oxygen Species	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	119-122
29145158-8	2018	Finally, V. cholerae lacking ompU elicited decreased IL-8 expression and adherence to HT-29 cells compared to the parental strain.	ompu	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
31258241-12	2018	However, only the perovskite and CaIrO3 structures are stable with respect to dissociation into NaF and MgF2.	perovskite	18-28	C-X-C motif chemokine ligand 8	Homo sapiens	96-99
30116274-9	2018	The level of serum IL-8 was significant higher in patients with FE than that of patients with NFE (209.0 pg/mL (ranged: 115-472) vs 65.6 pg/mL (ranged: 11.2-149.3), P=0.008).	Iron	64-66	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
30116274-9	2018	The level of serum IL-8 was significant higher in patients with FE than that of patients with NFE (209.0 pg/mL (ranged: 115-472) vs 65.6 pg/mL (ranged: 11.2-149.3), P=0.008).	nfe	94-97	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
29348982-0	2017	Pictorial atlas of symptomatic accessory ossicles by 18F-Sodium Fluoride (NaF) PET-CT. Accessory ossicles are developmental variants which are often asymptomatic.	18f-sodium fluoride	53-72	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
29348982-4	2017	18F-Sodium Fluoride (NaF) is a PET imaging agent used in bone imaging.	18f-sodium fluoride	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
29262362-3	2017	Here, we describe 1H-detected magic angle spinning solid-state NMR studies of monomeric IL-8 (1-66) bound to full-length and truncated constructs of CXCR1 in phospholipid bilayers under physiological conditions.	Hydrogen	18-20	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
29262362-3	2017	Here, we describe 1H-detected magic angle spinning solid-state NMR studies of monomeric IL-8 (1-66) bound to full-length and truncated constructs of CXCR1 in phospholipid bilayers under physiological conditions.	Phospholipids	158-170	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
29262362-4	2017	Cross-polarization experiments demonstrate that most backbone amide sites of IL-8 (1-66) are immobilized and that their chemical shifts are perturbed upon binding to CXCR1, demonstrating that the dynamics and environments of chemokine residues are affected by interactions with the chemokine receptor.	Amides	62-67	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
29258201-4	2017	Supplementation of the culture medium with particular fatty acids was found to have a promoting effect on cellular production of the cytokines IL-6, IL-8, GM-CSF, and MCP-1.	Fatty Acids	54-65	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
29262362-6	2017	Intermolecular paramagnetic relaxation enhancement broadening of IL-8 (1-66) signals results from interactions of the chemokine with CXCR1 (1-350) containing Mn2+ chelated to an unnatural amino acid assists in the characterization of the receptor-bound form of the chemokine.	Manganese(2+)	158-162	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
29260335-3	2017	It is found that the emission intensity of green and red light is enhanced for several times by the way of using NaBF4 as a fluoride source with the comparison of NH4F and NaF.	Sodium tetrafluoroborate	113-118	C-X-C motif chemokine ligand 8	Homo sapiens	172-175
29236068-15	2017	To support the ability to inhibit p38 MAPK, the treatment of javamide-II-ethyl and -methyl esters could suppress the production of IL-8 and MCP-1 protein significantly by 22-73% (p &lt; 0.05) in the differentiated THP-1 cells, and the inhibition was slightly stronger by the ethyl ester than the methyl ester.	javamide-ii-ethyl and -methyl esters	61-97	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
29236068-15	2017	To support the ability to inhibit p38 MAPK, the treatment of javamide-II-ethyl and -methyl esters could suppress the production of IL-8 and MCP-1 protein significantly by 22-73% (p &lt; 0.05) in the differentiated THP-1 cells, and the inhibition was slightly stronger by the ethyl ester than the methyl ester.	ethyl ester	85-96	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
29236068-15	2017	To support the ability to inhibit p38 MAPK, the treatment of javamide-II-ethyl and -methyl esters could suppress the production of IL-8 and MCP-1 protein significantly by 22-73% (p &lt; 0.05) in the differentiated THP-1 cells, and the inhibition was slightly stronger by the ethyl ester than the methyl ester.	methyl ester	84-96	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
29207957-12	2017	At high percentiles of IL-1beta, IFN-gamma and IL-8, women with CDMR had higher expression levels compared to women with VD.	cdmr	64-68	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
29416683-4	2018	In particular, H2O2-treated CCAR2-depleted cells showed a significant increase in interleukin-8 (IL-8) production, indicating a negative regulation of IL-8 by CCAR2.	Hydrogen Peroxide	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	82-95
29416683-4	2018	In particular, H2O2-treated CCAR2-depleted cells showed a significant increase in interleukin-8 (IL-8) production, indicating a negative regulation of IL-8 by CCAR2.	Hydrogen Peroxide	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
29416683-4	2018	In particular, H2O2-treated CCAR2-depleted cells showed a significant increase in interleukin-8 (IL-8) production, indicating a negative regulation of IL-8 by CCAR2.	Hydrogen Peroxide	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
29228979-8	2017	RESULTS: We demonstrate that bryostatin-1 induces secretion of chemokines CCL2 and IL-8 and proinflammatory cytokines IL-6 and GM-CSF, whereas their production is repressed by JQ1.	bryostatin 1	29-41	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
29207957-13	2017	Women with CDMI had higher levels at median percentiles of IL-1beta, IFN-gamma and IL-8.	2-(2-methyl-4-chlorophenylamino)-2-imidazoline	11-15	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
29207576-7	2017	Enzymatic GAG depolymerization via heparinase III and chondroitinase ABC was used to emulate the effect of glycocalyx remodeling on CXCL8-induced endothelial downstream signaling.	Glycosaminoglycans	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	132-137
29207957-15	2017	It is worth noting that at high percentiles, compared with normal delivery, the expression of IL-1beta, IFN-gamma, IL-8 and HO-1 have significantly altered in women with CDMR.	cdmr	170-174	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
29230430-10	2018	Conclusions: TEGDMA affects production of proinflammatory cytokines IL-1beta, IL-6, IL-8, IL-18 and TNF-alpha.	triethylene glycol dimethacrylate	13-19	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
29213094-3	2017	In this study, we investigated the toxic effect of sodium fluoride (NaF) exposure on porcine oocyte maturation and its possible underlying mechanisms.	Sodium Fluoride	51-66	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
29213094-7	2017	NaF exposure also induced oxidative stress, decreased GSH level, and increased cathepsin B activity in and impaired the further development potential of porcine oocytes, as indicated by a decrease in blastocyst formation rate, increase in apoptosis, and inhibition of cell proliferation.	Glutathione	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
28976240-8	2017	H2O2 and LPS up-regulated IL-8.	Hydrogen Peroxide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
29058460-2	2017	In the present study, we demonstrated that ginsenoside Rg1 induced secretion of cytokines, including interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha), and IL-1beta, and chemokines such as IL-8 and IP-10 in a dose-dependent manner by human peripheral blood mononuclear cell (PBMC)-derived dendritic cells.	Ginsenosides	43-54	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
28210997-1	2017	BACKGROUND: Sodium fluoride (NaF) positron emission tomography combined with computer tomography (PET/CT) has shown to be more sensitive than the whole-body bone scan in the detection of skeletal uptake due to metastases in prostate cancer.	Sodium Fluoride	12-27	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
28704260-6	2017	In vitro, we demonstrated, using cultured human PASMC from PAH patients, that alpha-solanine reversed dysfunctional AXIN2, beta-catenin and bone morphogenetic protein receptor type-2 signaling, whereas restored [Ca]i, IL-6 and IL-8, contributing to the decrease of PAH-PASMC proliferation and resistance to apoptosis.	alpha-solanine	78-92	C-X-C motif chemokine ligand 8	Homo sapiens	227-231
29193074-4	2017	Using quantitative real-time polymerase chain reaction, we measure mRNA expression of pro-inflammatory cytokines: TNF-alpha, Interleukin (IL)-1beta, IL-6, and chemokine IL-8 under PA and 1alpha,25(OH)2 D3 influence.	Palmitic Acid	180-182	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
28643937-7	2017	RESULTS: S100A9 and S100A8/A9 significantly upregulated IL-6 and IL-8 expression, which was inhibited upon treatment with the TLR4 inhibitor TAK242.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	141-147	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
27197820-3	2017	F-18 sodium fluoride (NaF) has been used to image inflammation in coronary artery plaques and has low background myocardial uptake.	Sodium Fluoride	5-20	C-X-C motif chemokine ligand 8	Homo sapiens	22-25
29285177-8	2017	The results demonstrated that after Simvastatin treatment of patients with acute cerebral hemorrhage at the ICU, the plasma concentrations of IL-4, IL-6, IL-8 and IL-10 were downregulated compared with those in placebo-treated controls.	Simvastatin	36-47	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
29242736-0	2017	Inguinal Herniation of Urinary Bladder on F-18 Sodium Fluoride (NaF) PET-CT. Inguinal herniation of urinary bladder is uncommon and usually an incidental finding in asymptomatic patients.	Fluorine-18	42-46	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
28953207-2	2017	Fluorine-18-sodium fluoride (F-NaF) PET-computed tomography (CT) has rapid single-pass extraction, fast clearance from the soft tissues and a better target to background ratio.	fluorine-18-sodium fluoride	0-27	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
27894951-0	2017	A pilot study of CXCL8 levels in crystal proven gout patients during allopurinol treatment and their association with cardiovascular disease.	Allopurinol	69-80	C-X-C motif chemokine ligand 8	Homo sapiens	17-22
27894951-3	2017	We hypothesized that the well-known cardiovascular protective effects of allopurinol could be related to effects of this drug on CXCL8 levels.	Allopurinol	73-84	C-X-C motif chemokine ligand 8	Homo sapiens	129-134
28242869-8	2017	Peripheral monocyte response to lipopolysaccharide stimulation was lower in alcohol-dependent subjects compared with controls for the proinflammatory cytokines interleukin-6 and interleukin-8.	Alcohols	76-83	C-X-C motif chemokine ligand 8	Homo sapiens	178-191
29038158-6	2017	CFA treatment induced CXCL1 and interleukin-8 mRNA in BEAS-2B and primary human bronchial epithelial cells through activation of both TRPM8 and TRPV1.	3-chloro-4-fluoroaniline	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	32-45
29242735-2	2017	Achievements from F-18 NaF PET/CT are: higher sensitivity of positron imaging, higher target background ratio with higher tracer accumulation in bone hydroxyapatite and higher specificity through CT correlation.	Durapatite	150-164	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
28065790-5	2017	Moreover, oxidative stress was evidenced only after exposure to CS, with a decrease secretion of GRO-alpha from 8min and of IL-8 and MCP-1 after 48min exposure.	Cesium	64-66	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
29242736-0	2017	Inguinal Herniation of Urinary Bladder on F-18 Sodium Fluoride (NaF) PET-CT. Inguinal herniation of urinary bladder is uncommon and usually an incidental finding in asymptomatic patients.	Sodium Fluoride	47-62	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
29083169-5	2017	All three astaxanthin isomers were effective in maintaining cellular redox homeostasis as seen in the antioxidant enzyme (CAT, SOD) activities ; 9Z- and 13Z- astaxanthins exhibited a higher protective effect than all-E-astaxanthin against oxidative stress as demonstrated by the lower cellular uptake of Z-astaxanthins and lower secretion and gene expression of the pro-inflammatory cytokine IL-8 in Caco-2 cells treated with H2O2.	astaxanthine	10-21	C-X-C motif chemokine ligand 8	Homo sapiens	392-396
28987380-7	2017	Ex vivo incubation with quercetin in blood of both IPF patients and healthy controls reduces LPS-induced production of the pro-inflammatory cytokines IL-8 and TNFalpha.	Quercetin	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
29083169-5	2017	All three astaxanthin isomers were effective in maintaining cellular redox homeostasis as seen in the antioxidant enzyme (CAT, SOD) activities ; 9Z- and 13Z- astaxanthins exhibited a higher protective effect than all-E-astaxanthin against oxidative stress as demonstrated by the lower cellular uptake of Z-astaxanthins and lower secretion and gene expression of the pro-inflammatory cytokine IL-8 in Caco-2 cells treated with H2O2.	9z- and 13z- astaxanthins	145-170	C-X-C motif chemokine ligand 8	Homo sapiens	392-396
29285315-7	2017	In indirect co-cultures, not only signal pathway inhibitors but also neutralizing antibodies against CXCL8, CXCR1 and CXCR2 suppressed these phenotypes induced by TAM-like PBMo-derived macrophages.	tam	163-166	C-X-C motif chemokine ligand 8	Homo sapiens	101-106
29172280-2	2017	SKOV3 cells displayed platinum-inducedIL-6 and IL-8 overproduction whereas wild type A2780 displayed no detectable cytokine production.	Platinum	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
29172280-5	2017	However, carboplatin-induced IL-6 and IL-8 production had a significant association withthe clinical response to chemotherapy (P=0.016 and P=0.038 respectively).	Carboplatin	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
29172280-6	2017	Carboplatin-induced IL-8 overproductionwas correlated with FIGO staging III-IV (P=0.026), but no correlation between carboplatin-induced IL-6 and FIGOstaging (P= 0.061) was noted.	Carboplatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
29209219-2	2017	Signaling through p38MAPK, ERK, Rho kinase, and MSK-CREB contributes to LPA-mediated IL-8 production in fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients.	lysophosphatidic acid	72-75	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
29209219-12	2017	In TNFalpha-primed RAFLS the super-production of IL-8 and IL-6 induced by LPA occurs mainly via MSK-independent pathways, and simultaneous inhibition of at least two MAPK signaling pathways was required to block their synthesis.	lysophosphatidic acid	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
29209219-13	2017	Since simultaneous inhibition of both the p38MAPK and ERK-MSK-CREB pathways are required to significantly reduce LPA-mediated IL-8 and IL-6 production in TNFalpha-preconditioned RAFLS, drug combinations targeting these two pathways are potential new strategies to treat rheumatoid arthritis.	lysophosphatidic acid	113-116	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
29178922-12	2017	LPA induced the release of IL-8 from ESCs but did not affect cell proliferation and VEGF production.	lysophosphatidic acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
29160802-9	2017	Contrariwise, the modification of the surface chemistry increased the apparent dielectric constant of NaF-water solution by promoting fluoride transmission.	Water	106-111	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
29160802-9	2017	Contrariwise, the modification of the surface chemistry increased the apparent dielectric constant of NaF-water solution by promoting fluoride transmission.	Fluorides	134-142	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
29312586-9	2017	Thus, glucose affects tamoxifen responsiveness directly modulating CTGF in BC cells, and indirectly promoting IL8 release by adipocytes.	Glucose	6-13	C-X-C motif chemokine ligand 8	Homo sapiens	110-113
29147010-8	2017	The effects of TDI exposure on FLCN production was investigated by treating HAECs (A549 cells) with TDI-human serum albumin conjugate, which showed increased expression and release of FLCN and interleukin-8 from HAECs.	Toluene 2,4-Diisocyanate	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	193-206
29131834-7	2017	Pathway analysis of potential mRNAs targets of these miRNA revealed in the DLBCL group potential up-regulation of STAT3, IL8, p13k/AKT and TGF-B signaling, and potential down-regulation of the PTEN and p53 pathways; while in the HL group we have found the cAMP-mediated pathway and p53 pathway to be potentially down-regulated.	Cyclic AMP	256-260	C-X-C motif chemokine ligand 8	Homo sapiens	121-124
28842514-10	2017	The poly(I:C)-induced release of inflammatory mediators, including CXCL8, interleukin (IL)-6 and CXCL1, from ASMCs from cough patients was significantly impaired compared with healthy non-cough subjects.	poly	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	67-72
28842514-10	2017	The poly(I:C)-induced release of inflammatory mediators, including CXCL8, interleukin (IL)-6 and CXCL1, from ASMCs from cough patients was significantly impaired compared with healthy non-cough subjects.	Iodine	9-10	C-X-C motif chemokine ligand 8	Homo sapiens	67-72
28842514-10	2017	The poly(I:C)-induced release of inflammatory mediators, including CXCL8, interleukin (IL)-6 and CXCL1, from ASMCs from cough patients was significantly impaired compared with healthy non-cough subjects.	asmcs	109-114	C-X-C motif chemokine ligand 8	Homo sapiens	67-72
29750184-6	2018	Results: In samples from 14 patients we confirmed a strongly compartmentalized immune response at the disease site and found that prednisolone significantly reduced IL-6 concentrations in plasma by 8 hours of treatment, IL-1beta concentrations in saliva, as well as IL-8 concentrations in both pericardial fluid and saliva by 24 hours.	Prednisolone	130-142	C-X-C motif chemokine ligand 8	Homo sapiens	266-270
29290940-0	2017	Lysophosphatidylcholine induces cytotoxicity/apoptosis and IL-8 production of human endothelial cells: Related mechanisms.	Lysophosphatidylcholines	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
29290940-15	2017	LPC-induced apoptosis, and IL-8 expression/secretion was attenuated by LY294002, a PI3K/Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
29133478-1	2017	BACKGROUND: 18F-sodium fluoride (18F-NaF) positron-emission tomography has been introduced as a potential noninvasive imaging tool to identify plaques with high-risk characteristics in patients with coronary artery disease.	18f-sodium fluoride	12-31	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
29096855-9	2017	Moreover, excretion of IL-8 into the medium rapidly increased up to 1.7 +- 0.3 fold in response to treatment of ADSCs with DHA.	Docosahexaenoic Acids	123-126	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
28866366-1	2017	Interleukin-8 (CXCL8) was originally described asa chemokine whose main function is the attraction of a polymorphonuclear inflammatory leukocyte infiltrate acting on CXCR1/2.	Aspirin	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
28866366-1	2017	Interleukin-8 (CXCL8) was originally described asa chemokine whose main function is the attraction of a polymorphonuclear inflammatory leukocyte infiltrate acting on CXCR1/2.	Aspirin	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
28866366-5	2017	Thus, IL-8 serum concentrations have been shown to be useful asa pharmacodynamic biomarker to early detect response to immunotherapy.	Aspirin	61-64	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
29093275-4	2017	HuMax-IL8 was shown to revert mesenchymalization in claudin-low TNBC models both in vitro and in vivo as well as to significantly decrease the recruitment of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) at the tumor site, an effect substantiated when used in combination with docetaxel.	Docetaxel	294-303	C-X-C motif chemokine ligand 8	Homo sapiens	0-9
28852782-1	2017	An ultrasensitive surface-enhanced Raman scattering (SERS) immunoassay based on diatom biosilica with integrated gold nanoparticles (AuNPs) for the detection of interleukin 8 (IL-8) in blood plasma has been developed.	sers	53-57	C-X-C motif chemokine ligand 8	Homo sapiens	161-174
28852782-1	2017	An ultrasensitive surface-enhanced Raman scattering (SERS) immunoassay based on diatom biosilica with integrated gold nanoparticles (AuNPs) for the detection of interleukin 8 (IL-8) in blood plasma has been developed.	sers	53-57	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
28852782-8	2017	To the best of our knowledge, this is the first report on the recognition of IL-8 in human samples using a SERS-based method.	sers	107-111	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
28852782-11	2017	This SERS immunoassay also exhibits high biological specificity for the detection of IL-8 antigens.	sers	5-9	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
28852782-13	2017	Graphical Abstract The SERS-based immunoassay based on naturally generated photonic biosilica for the detection of interleukin 8 (IL-8) in human plasma samples.	sers	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	115-128
28852782-13	2017	Graphical Abstract The SERS-based immunoassay based on naturally generated photonic biosilica for the detection of interleukin 8 (IL-8) in human plasma samples.	sers	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
28012895-2	2017	The cells were treated with sodium fluoride (NaF) alone and in combination with PCAME for different time points (0-24 h) and evaluated for intracellular reactive oxygen species (ROS) production, F- content, oxidative stress markers, apoptosis and mRNA expression of redox signaling and inflammatory genes.	Sodium Fluoride	28-43	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
28872551-0	2017	Diagnostic Challenge of Staging Metastatic Bone Disease in the Morbidly Obese Patients: A Primary Study Evaluating the Usefulness of 18F-Sodium Fluoride (NaF) PET-CT. PURPOSE: Optimizing diagnostic imaging may be challenging in obese patients.	18f-sodium fluoride	133-152	C-X-C motif chemokine ligand 8	Homo sapiens	154-157
28872551-2	2017	In comparison, sodium fluoride (F-NaF PET-CT) has a better target-to-background ratio attributed to rapid single-pass extraction and fast clearance from the soft tissues.	Sodium Fluoride	15-30	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
28872551-3	2017	The aim of the present study is to assess the diagnostic efficacy of F-NaF PET-CT in the evaluation of bone metastases in obese cancer patients.	Fluorine	69-70	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
26663823-9	2017	The GSH/GSSG ratio negatively correlated with IL-6 (P: 0.014), IL-8 (P: 0.014) and IL-10 (P: 0.033).	Glutathione Disulfide	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
26663823-9	2017	The GSH/GSSG ratio negatively correlated with IL-6 (P: 0.014), IL-8 (P: 0.014) and IL-10 (P: 0.033).	Glutathione Disulfide	8-12	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
28901414-6	2017	Brassinin treatment also markedly decreased the mRNA expression levels of interleukin-8 in a dose-dependent manner.	brassinin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
28736998-0	2017	Evasin-displaying lactic acid bacteria bind different chemokines and neutralize CXCL8 production in Caco-2 cells.	Lactic Acid	18-29	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
28901435-7	2017	The nuclear factor-kappaB inhibitor, Bay 11-7082, decreased the TNF-alpha-mediated expression of IL-8 and CXCL10 in the absence, and presence of IFN-gamma.	3-(4-methylphenylsulfonyl)-2-propenenitrile	37-48	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
28912098-2	2017	Melatonin, an indolamine synthesized in the pineal gland, was previously shown to protect against sodium fluoride (NaF)-induced hepatotoxicity.	Melatonin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	115-118
28912098-2	2017	Melatonin, an indolamine synthesized in the pineal gland, was previously shown to protect against sodium fluoride (NaF)-induced hepatotoxicity.	indolamine	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	115-118
28912098-2	2017	Melatonin, an indolamine synthesized in the pineal gland, was previously shown to protect against sodium fluoride (NaF)-induced hepatotoxicity.	Sodium Fluoride	98-113	C-X-C motif chemokine ligand 8	Homo sapiens	115-118
28912098-3	2017	This study investigated the protective effects of melatonin pretreatment on NaF-induced hepatotoxicity and elucidates the potential mechanism of melatonin-mediated protection.	Melatonin	50-59	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
28912098-4	2017	Reducing mitochondrial ROS by melatonin substantially attenuated NaF-induced NADPH oxidase 4 (Nox4) upregulation and cytotoxicity in L-02 cells.	Reactive Oxygen Species	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
28912098-4	2017	Reducing mitochondrial ROS by melatonin substantially attenuated NaF-induced NADPH oxidase 4 (Nox4) upregulation and cytotoxicity in L-02 cells.	Melatonin	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
28912098-11	2017	Our findings provided a theoretical basis that melatonin mitigated NaF-induced hepatotoxicity, which, in part, was mediated through the activation of the Sirt3 pathway.	Melatonin	47-56	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
28657808-9	2017	Among the fluoride compounds, NaF was mentioned more frequently than SnF2, Na2PO3F, amine fluoride, and acidulated phosphate fluoride during the years 1986 to 2015.	Fluorides	10-18	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
28798033-11	2017	Conclusion:18F-NaF PET/CT and whole-body SPECT/CT resulted in a significant reduction of equivocal readings compared with pBS, which implies an improved diagnostic confidence.	pbs	122-125	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
28849160-4	2017	The results indicated that GBP and PGB suppressed the SP-induced production of IL-6, and IL-8 in U373 MG cells.	Pregabalin	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
28849160-6	2017	Together, these observations suggest that GBP and PGB likely prevent SP-induced IL-6 and IL-8 production in U373 MG cells via the inhibition of signaling molecules, including p38 MAPK and NF-kappaB, thereby exhibiting antineuroinflammatory effects.	Pregabalin	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
29068698-4	2017	Polyphenols influence the inflammatory process by controlling and inhibiting pro-inflammatory cytokines such as IL-1beta, IL-6, IL-8, and TNF-alpha, and cyclooxygenase-2 (COX-2) enzyme involved in the metabolism of arachidonic acid.	Polyphenols	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
28877084-1	2017	OBJECTIVE: Coronary artery fluorine-18-sodium fluoride (F-NaF) uptake reflects coronary artery calcification metabolism and is considered to be an early prognostic marker of coronary heart disease.	fluorine-18-sodium fluoride	27-54	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
28865757-7	2017	Only the highest concentration tested of L-AmB (400mug/ml) yielded transient significant 6-fold and 4-fold induction of TNF-alpha and IL-8 mRNAs, respectively.	liposomal amphotericin B	41-46	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
28494217-5	2017	The IL-8 concentration determined on day 1 was significantly negatively correlated with creatinine clearance early after renal transplantation (on days 1, 7, 14 and 30), as well as during long-term observations.	Creatinine	88-98	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
28865757-9	2017	Significant 4-fold, 7-fold and 3-fold inductions of TNF-alpha, IL-8 and IL-33 mRNAs were also observed at 6h with 50mug/ml of D-AmB.	Deoxycholate-AmB	126-131	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
28766731-13	2017	Levels of CXCL-8 (C-X-C motif chemokine ligand 1) and interleukin-6 were significantly higher after treatment with RMPs.	rmps	115-119	C-X-C motif chemokine ligand 8	Homo sapiens	10-16
29168724-2	2017	Thermodynamic analysis of four possible additives, Na2CO3, Na2C2O4, NaF and Na2SO4, indicated that both carbonate and oxalate could potentially provide effective separation of Ca via precipitation from Mg in FGD wastewater.	Carbonates	104-113	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
29168724-2	2017	Thermodynamic analysis of four possible additives, Na2CO3, Na2C2O4, NaF and Na2SO4, indicated that both carbonate and oxalate could potentially provide effective separation of Ca via precipitation from Mg in FGD wastewater.	Oxalates	118-125	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
28883082-4	2017	In our study, we found that CXCL8 was highly expressed in cervical cancer tissues compared with normal cervical tissues in microarray datasets (GSE9750 and GSE7803).	gse9750	144-151	C-X-C motif chemokine ligand 8	Homo sapiens	28-33
29085059-9	2017	However, KL excess via overexpression or supplementation decreased IL-8 secretion by inhibiting Smad 3 phosphorylation.	Kraft lignin	9-11	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
28823917-2	2017	To examine an alternative approach of integrin-based anti-osteosacoma strategy, acurhagin-C, a Glu-Cys-Asp (ECD)-disintegrin, was isolated and evaluated for its application in combination with two potent inhibitors of basic fibroblast growth factor (bFGF) and interleukin-8 (IL-8).	acurhagin-c	80-91	C-X-C motif chemokine ligand 8	Homo sapiens	260-273
28823917-2	2017	To examine an alternative approach of integrin-based anti-osteosacoma strategy, acurhagin-C, a Glu-Cys-Asp (ECD)-disintegrin, was isolated and evaluated for its application in combination with two potent inhibitors of basic fibroblast growth factor (bFGF) and interleukin-8 (IL-8).	acurhagin-c	80-91	C-X-C motif chemokine ligand 8	Homo sapiens	275-279
28899503-10	2017	RESULTS: Under non-inflammatory conditions P. tremula E and ASA increased cellular proteins (P) IL-8 and IL-10; S. virgaurea E modulated IL-1alpha, IL-10, IL-15 and Groalpha (P).	Aspirin	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
28899503-16	2017	Secretion of IL-8 and IL-6 was reduced by STW1 and ASA.	Aspirin	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
28883082-4	2017	In our study, we found that CXCL8 was highly expressed in cervical cancer tissues compared with normal cervical tissues in microarray datasets (GSE9750 and GSE7803).	gse7803	156-163	C-X-C motif chemokine ligand 8	Homo sapiens	28-33
28836077-7	2017	CONCLUSIONS: Patients with T2D display a marked elevation of circulating IL-8 levels which identify subjects with worse inflammatory, glycometabolic and lipid profile and lower vitamin D levels.	Vitamin D	177-186	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
28986583-6	2017	Nicotine at 10 micromol/L significantly downregulated the release of TNF-alpha, but showed a lesser effect on IL-8 secretion and no effect on TGF-beta.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
28864214-4	2017	Moreover, levels of serum miR-218 positively correlated with FEV1/FVC% and negatively correlated with levels of serum IL-6 and IL-8.	mir-218	26-33	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
28976943-9	2017	High glucose-induced secretion of IL-8, TNF-alpha, ICAM-1, and VCAM-1 was reduced, and translocation of the p65 subunit of NF-kappaB to the endothelial cell nucleus was inhibited by EOFAZ.	Glucose	5-12	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
28860213-1	2017	Our aim was to prospectively evaluate the relationship between low back pain-related disability and quantitative measures from [18F]-sodium fluoride ([18F]-NaF) MR imaging.	[18f]-sodium fluoride	127-148	C-X-C motif chemokine ligand 8	Homo sapiens	156-159
28701056-7	2017	Treatment of IL-1beta stimulated fibroblasts in combination with PHMG-P or CHX at concentrations of 0.000045 or 0.0.00009% resulted in significantly decreased PGE2, IL-6, IL-8 and MMP-1 levels.	polyhexamethyleneguanidine	65-71	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
28701056-7	2017	Treatment of IL-1beta stimulated fibroblasts in combination with PHMG-P or CHX at concentrations of 0.000045 or 0.0.00009% resulted in significantly decreased PGE2, IL-6, IL-8 and MMP-1 levels.	Chlorhexidine	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
28860213-5	2017	These data suggest that dynamic [18F]-NaF PET may serve as a useful biomarker for facetogenic disability.	Fluorine-18	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
28928970-9	2017	While UA significantly inhibited NO expression with time course- and dose- dependent manner in the cultured ECs, 10 mg/dl UA also increased expression of inflammation cytokine interleukin (IL)-6, IL-8 and tumor necrosis factor-alpha in vitro.	Uric Acid	122-124	C-X-C motif chemokine ligand 8	Homo sapiens	196-232
28601733-0	2017	Effect of 1.2% of simvastatin gel as a local drug delivery system on Gingival Crevicular Fluid interleukin-6 &amp; interleukin-8 levels in non surgical treatment of chronic periodontitis patients.	Simvastatin	18-29	C-X-C motif chemokine ligand 8	Homo sapiens	115-128
28601733-1	2017	AIM: The present study was carried out to evaluate the effect of 1.2% simvastatin gel as local drug delivery (LDD) system on Gingival Crevicular Fluid (GCF) Interleukin -6 (IL-6) and Interleukin-8 (IL-8) levels in chronic periodontitis patients, in addition to scaling and root planing (SRP).	Simvastatin	70-81	C-X-C motif chemokine ligand 8	Homo sapiens	183-196
28601733-1	2017	AIM: The present study was carried out to evaluate the effect of 1.2% simvastatin gel as local drug delivery (LDD) system on Gingival Crevicular Fluid (GCF) Interleukin -6 (IL-6) and Interleukin-8 (IL-8) levels in chronic periodontitis patients, in addition to scaling and root planing (SRP).	Simvastatin	70-81	C-X-C motif chemokine ligand 8	Homo sapiens	198-202
28892713-7	2017	SA also impairs CAC function and increases pro-inflammatory molecule (IL-1beta, IL-6, IL-8, MCP-1 and TNFalpha) gene expression and secretion in CACs starting from 3 h of incubation.	stearic acid	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
29084500-12	2017	Driving pressures &gt;= 19 cmH2O before ECMO were associated with higher IL8 levels.	cmh2o	27-32	C-X-C motif chemokine ligand 8	Homo sapiens	73-76
28550976-7	2017	The effect of anti-proliferative agent Mitomycin C upon secretion of pro-inflammatory cytokines IL-6 and IL-8 was assessed.	Mitomycin	39-50	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
28966687-8	2017	A significant positive correlation was identified between the neutrophil polys and expression levels of four of these candidate genes, including CXCL2, IL8, TRIM58, and IGSF3 (all P&lt;0.01; R2&gt;=0.64).	polys	73-78	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
28512018-6	2017	Moreover, NC-DFZ reduced the lipopolysaccharide (LPS) mediated secretion of the inflammatory marker IL-8.	nc-dfz	10-16	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
28849137-5	2017	Furthermore, NW-PM2.5 and W-PM2.5 significantly reduced sebaceous lipid synthesis and markedly promoted the production of inflammatory cytokines, including interleukin-1alpha (IL-1alpha), IL-6 and IL-8 in SZ95 sebocytes.	nw-pm2	13-19	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
28730511-0	2017	Intermediate Molecular Mass Hyaluronan and CD44 Receptor Interactions Enhance Neutrophil Phagocytosis and IL-8 Production via p38- and ERK1/2-MAPK Signalling Pathways.	Hyaluronic Acid	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
28849137-5	2017	Furthermore, NW-PM2.5 and W-PM2.5 significantly reduced sebaceous lipid synthesis and markedly promoted the production of inflammatory cytokines, including interleukin-1alpha (IL-1alpha), IL-6 and IL-8 in SZ95 sebocytes.	w-pm2	14-19	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
28109921-1	2017	OBJECTIVES: The aims of this study were to describe the authors" initial experience with combined coronary artery positron emission tomographic (PET) and magnetic resonance (MR) imaging using 18F-fluorodeoxyglucose (18F-FDG) and 18F-sodium fluoride (18F-NaF) radiotracers, describe common problems and their solutions, and demonstrate the feasibility of coronary PET/MR imaging in appropriate patients.	Fluorodeoxyglucose F18	192-214	C-X-C motif chemokine ligand 8	Homo sapiens	254-257
29058282-8	2017	4-PBA significantly reduced the expression of CXCL-8 protein (P&lt;0.05) and neutrophil migration (P&lt;0.05).	4-phenylbutylamine	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	46-52
28743324-3	2017	Triptolide pretreatment significantly inhibited tumor necrosis factor-alpha-induced expression of the interleukin (IL)-1beta, IL-6, and IL-8 genes in MH7A cells.	triptolide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
29055398-3	2017	While corticosteroid therapy is currently the recommended treatment for HSP, dapsone, an anti-leprosy agent, has also recently been suggested to have therapeutic efficacy due to its ability to suppress IL-8.	Dapsone	77-84	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
29132841-6	2017	Pg-3-glc and PGA at 0.08 mumol/L increased the concentration of IL-10 (P&lt;.01 and P&lt;.001, respectively), but there was no effect on tumor necrosis factor-alpha, IL-1beta, IL-6, and IL-8, and there were no effects of the other compounds.	pelargonidin-3-glucoside	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
28691370-7	2017	Subsequent experiment using an inflamed Caco-2 BBe1/THP-1 co-culture cell model showed these transported anthocyanins inhibited IL-8 and TNF-alpha secretion,and expression of pro-inflammatory cytokines by blocking NF-kappaB, and MAPK mediated inflammatory cellular signaling cascades, but with varying degrees due to structural features.	Anthocyanins	105-117	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
28427103-10	2017	Kaempferol-3-O-sophoroside (10-50 microM), but not saffron flower acetone extract, inhibited TNF-alpha-induced IL-8 secretion.	kaempferol 3-O-sophoroside	0-26	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
29132841-6	2017	Pg-3-glc and PGA at 0.08 mumol/L increased the concentration of IL-10 (P&lt;.01 and P&lt;.001, respectively), but there was no effect on tumor necrosis factor-alpha, IL-1beta, IL-6, and IL-8, and there were no effects of the other compounds.	Folic Acid	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
28777220-0	2017	Normal bone and soft tissue distribution of fluorine-18-sodium fluoride and artifacts on 18F-NaF PET/CT bone scan: a pictorial review.	fluorine-18-sodium fluoride	44-71	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
28777220-1	2017	Fluorine-18-sodium fluoride (F-NaF) PET/CT is a relatively new and high-resolution bone imaging modality.	fluorine-18-sodium fluoride	0-27	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
28929009-13	2017	Furthermore, the results showed that IL-7, IL-8, IL-10, TGF-b, and VEGFR2 display peak differences between DF and SDI during or before the critical phase (day 4-5) of SDI.	sdi	114-117	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
28823947-17	2017	Moreover, inhalation of GSK2269557 resulted in suppression of sputum IL-8 and IL-6 levels, consistent with the known anti-inflammatory activity of a PI3Kdelta inhibitor.	gsk2269557	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
29033853-9	2017	Results: The major findings of these analyses were: (1) MCs secreted HMGB1 from the nucleus during exposure to high glucose levels; HMGB1 acted in an autocrine fashion on the MCs to promote the production of MCP-1 and IL-8; (2) HMGB1 had little effect on high-glucose-induced apoptosis of the MCs; and (3) HMGB1-mediated MCP-1 and IL-8 production depended on the activation of MAPK signaling pathways.	mcs	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	218-222
29033853-9	2017	Results: The major findings of these analyses were: (1) MCs secreted HMGB1 from the nucleus during exposure to high glucose levels; HMGB1 acted in an autocrine fashion on the MCs to promote the production of MCP-1 and IL-8; (2) HMGB1 had little effect on high-glucose-induced apoptosis of the MCs; and (3) HMGB1-mediated MCP-1 and IL-8 production depended on the activation of MAPK signaling pathways.	mcs	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	331-335
29033853-9	2017	Results: The major findings of these analyses were: (1) MCs secreted HMGB1 from the nucleus during exposure to high glucose levels; HMGB1 acted in an autocrine fashion on the MCs to promote the production of MCP-1 and IL-8; (2) HMGB1 had little effect on high-glucose-induced apoptosis of the MCs; and (3) HMGB1-mediated MCP-1 and IL-8 production depended on the activation of MAPK signaling pathways.	mcs	175-178	C-X-C motif chemokine ligand 8	Homo sapiens	218-222
29033853-9	2017	Results: The major findings of these analyses were: (1) MCs secreted HMGB1 from the nucleus during exposure to high glucose levels; HMGB1 acted in an autocrine fashion on the MCs to promote the production of MCP-1 and IL-8; (2) HMGB1 had little effect on high-glucose-induced apoptosis of the MCs; and (3) HMGB1-mediated MCP-1 and IL-8 production depended on the activation of MAPK signaling pathways.	mcs	175-178	C-X-C motif chemokine ligand 8	Homo sapiens	331-335
29033853-9	2017	Results: The major findings of these analyses were: (1) MCs secreted HMGB1 from the nucleus during exposure to high glucose levels; HMGB1 acted in an autocrine fashion on the MCs to promote the production of MCP-1 and IL-8; (2) HMGB1 had little effect on high-glucose-induced apoptosis of the MCs; and (3) HMGB1-mediated MCP-1 and IL-8 production depended on the activation of MAPK signaling pathways.	mcs	175-178	C-X-C motif chemokine ligand 8	Homo sapiens	218-222
29033853-9	2017	Results: The major findings of these analyses were: (1) MCs secreted HMGB1 from the nucleus during exposure to high glucose levels; HMGB1 acted in an autocrine fashion on the MCs to promote the production of MCP-1 and IL-8; (2) HMGB1 had little effect on high-glucose-induced apoptosis of the MCs; and (3) HMGB1-mediated MCP-1 and IL-8 production depended on the activation of MAPK signaling pathways.	mcs	175-178	C-X-C motif chemokine ligand 8	Homo sapiens	331-335
28929009-14	2017	DISCUSSION: This meta-analysis suggests that IL-7, IL-8, IL-10, TGF-b, and VEGFR2 may be used as potential early laboratory biomarkers in the diagnosis of SDI.	sdi	155-158	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
28820234-1	2017	We developed a method of chemically welding silver nanowires (AgNWs) using an aqueous solution containing sodium halide salts (NaF, NaCl, NaBr, or NaI).	sodium halide salts	106-125	C-X-C motif chemokine ligand 8	Homo sapiens	127-130
28891967-7	2017	Ginsenoside Rg3 (10 mug/mL) effectively suppressed the expressions of IL-6 and IL-8, which is associated with regulations of NF-kappaB and p38MAPK activation.	Ginsenosides	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
28878123-5	2017	SOD mimetic (Mn (III) tetrakis (N-ethylpyridinium-2-yl) porphyrin) attenuated Alternaria-induced expression of IL-33 and IL-8 release in BEAS-2B cells.	mn (iii) tetrakis (n-ethylpyridinium-2-yl) porphyrin	13-65	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
29254155-4	2017	Casticin decreased levels of IL-6, tumor necrosis factor alpha, and IL-8 and suppressed COX-2 expression and prostaglandin E2 production.	casticin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
28650029-8	2017	The present study shows that the amine-modified MSNs could encapsulate BA and BE, and nano-encapsulation greatly enhances the drug delivery rate and prolongs the release of BA and BE up to 216 h. Moreover, both Nano-BA and Nano-BE could be internalized by hGECs and retained intracellularly in nanoparticle-free media for at least 24 h. Note that Nano-BE pre-treatment effectively down-regulates the IL-1beta-induced expression of IL-6 and IL-8 in hGECs.	Amines	33-38	C-X-C motif chemokine ligand 8	Homo sapiens	440-444
28736978-1	2017	Chemokine cysteine-X-cysteine motif ligand 8 (CXCL8) is up-regulated in many malignancies, indicating that CXCL8 takes part in tumor progression.	cysteine-x-cysteine	10-29	C-X-C motif chemokine ligand 8	Homo sapiens	46-51
28869519-6	2017	A cleft containing the predicted sulfotyrosine-binding pocket was identified as a principal hot spot for ligand binding on the structures of CXCL1, CXCL2, CXCL7, and CXCL8, but not CXCL5.	tyrosine O-sulfate	33-46	C-X-C motif chemokine ligand 8	Homo sapiens	166-171
28869519-7	2017	Sulfotyrosine titrations monitored via NMR spectroscopy showed specific binding to CXCL8, but not to CXCL5, which is consistent with the predictions from the computational solvent mapping.	tyrosine O-sulfate	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	83-88
28869519-8	2017	The lack of CXCL5-sulfotyrosine interaction and the presence of CXCL8-sulfotyrosine binding suggests a role for receptor post-translational modifications regulating ligand selectivity.	tyrosine O-sulfate	70-83	C-X-C motif chemokine ligand 8	Homo sapiens	64-69
28736978-1	2017	Chemokine cysteine-X-cysteine motif ligand 8 (CXCL8) is up-regulated in many malignancies, indicating that CXCL8 takes part in tumor progression.	cysteine-x-cysteine	10-29	C-X-C motif chemokine ligand 8	Homo sapiens	107-112
28412861-7	2017	The change in IL8 mRNA was negatively associated with AR expression in the presence of NETA.	Norethindrone Acetate	87-91	C-X-C motif chemokine ligand 8	Homo sapiens	14-17
28111709-1	2017	Sodium fluoride (NaF) is a source of fluoride ions used in many applications.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
28111709-1	2017	Sodium fluoride (NaF) is a source of fluoride ions used in many applications.	Fluorides	7-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
28111709-12	2017	Further, the fluorescence intensities of ROS in the NaF groups were higher than those in the control group, and the membrane potential of mitochondria in the NaF group was significantly lower than that of the control group (P &lt; 0.05).	ros	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
28700977-6	2017	Hypoxia-induced Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin 6 (IL-6), and Interleukin 8 (IL-8) release were significantly reduced in the neferine pretreated samples indicating its anti-inflammatory role.	neferine	146-154	C-X-C motif chemokine ligand 8	Homo sapiens	83-96
28700977-6	2017	Hypoxia-induced Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin 6 (IL-6), and Interleukin 8 (IL-8) release were significantly reduced in the neferine pretreated samples indicating its anti-inflammatory role.	neferine	146-154	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
28437599-7	2017	The ASMCs were cultured with HBD-3 for 24 hour, and then the supernatant level of IL-8 was evaluated by ELISA and the cell viability was examined by WST-1 assay.	asmcs	4-9	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
28437599-12	2017	Mitochondrial ROS regulated both HBD-3-induced IL-8 production and cell apoptosis.	ros	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
28738247-7	2017	In vivo, asiatic acid significantly inhibited LPS-induced IL-6 and IL-8 expression levels in gingival tissues.	asiatic acid	9-21	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
28738247-8	2017	In vitro, LPS-induced PGE2, NO, IL-6, and IL-8 production was significantly attenuated by asiatic acid.	asiatic acid	90-102	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
28692879-3	2017	The results showed that pitavastatin inhibited the expression of inflammatory mediators IL-6 and IL-8.	pitavastatin	24-36	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
28738247-11	2017	Furthermore, GW9662, a PPAR-gamma inhibitor, attenuated the inhibitory effect of asiatic acid on PGE2, NO, IL-6, and IL-8 production.	2-chloro-5-nitrobenzanilide	13-19	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
28692879-6	2017	These findings suggest that the mechanism underlying the inhibitory effects of pitavastatin on IL-1beta-induced IL-6 and IL-8 release might be mediated by the suppression of mitogen-activated protein kinase (MAPK), Akt, and nuclear factor-kappaB (NF-kappaB) signaling pathways.	pitavastatin	79-91	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
28738247-11	2017	Furthermore, GW9662, a PPAR-gamma inhibitor, attenuated the inhibitory effect of asiatic acid on PGE2, NO, IL-6, and IL-8 production.	asiatic acid	81-93	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
28883755-3	2017	Here, we demonstrate that hypoxia, reactive oxygen species (ROS), and differential concentration of glucose influence the expression of cytokines and chemokines, such as IL-6, IL-8, and IP-10, in human glial cell lines.	Reactive Oxygen Species	35-58	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
28713941-5	2017	Celecoxib and simvastatin alone as well as a combined treatment showed a significant reduction in tumor cell viability, proliferation and secretion of IL-6 and IL-8 compared to the control group.	Celecoxib	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
28713941-5	2017	Celecoxib and simvastatin alone as well as a combined treatment showed a significant reduction in tumor cell viability, proliferation and secretion of IL-6 and IL-8 compared to the control group.	Simvastatin	14-25	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
28547650-9	2017	Exposure to Leu-Leu-OMe significantly promoted the production of IL-6 and IL-8 in primed HUVECs; this effect was prevented by the pre-treatment of cells with an IL-1RA.	leucyl-leucine-methyl ester	12-23	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
28764952-0	2017	Prospective comparison of 18F-NaF PET/CT versus 18F-FDG PET/CT imaging in mandibular extension of head and neck squamous cell carcinoma with dedicated analysis software and validation with surgical specimen.	Fluorine-18	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
28247965-0	2017	Lithocholic Acid Stimulates IL-8 Expression in Human Colorectal Cancer Cells Via Activation of Erk1/2 MAPK and Suppression of STAT3 Activity.	Lithocholic Acid	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
28247965-3	2017	However, the effect of LCA on IL-8 expression is still undefined.	Lithocholic Acid	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
28247965-4	2017	In this study, we observed that LCA treatment induced IL-8 expression in CRC HCT116 cells.	Lithocholic Acid	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
28247965-5	2017	Pharmacological inhibition and mutagenesis studies indicated that Erk1/2 is critical for LCA-induced IL-8 expression.	Lithocholic Acid	89-92	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
28247965-6	2017	Furthermore, LCA reduced the phosphorylation of STAT3, and the STAT3 inhibitor Stattic, accelerated LCA-induced IL-8 expression, suggesting that STAT3 is involved in LCA-induced IL-8 expression.	Lithocholic Acid	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
28247965-6	2017	Furthermore, LCA reduced the phosphorylation of STAT3, and the STAT3 inhibitor Stattic, accelerated LCA-induced IL-8 expression, suggesting that STAT3 is involved in LCA-induced IL-8 expression.	Lithocholic Acid	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
28247965-6	2017	Furthermore, LCA reduced the phosphorylation of STAT3, and the STAT3 inhibitor Stattic, accelerated LCA-induced IL-8 expression, suggesting that STAT3 is involved in LCA-induced IL-8 expression.	Lithocholic Acid	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
28247965-6	2017	Furthermore, LCA reduced the phosphorylation of STAT3, and the STAT3 inhibitor Stattic, accelerated LCA-induced IL-8 expression, suggesting that STAT3 is involved in LCA-induced IL-8 expression.	Lithocholic Acid	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
28247965-6	2017	Furthermore, LCA reduced the phosphorylation of STAT3, and the STAT3 inhibitor Stattic, accelerated LCA-induced IL-8 expression, suggesting that STAT3 is involved in LCA-induced IL-8 expression.	Lithocholic Acid	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
28247965-8	2017	In conclusion, LCA activated Erk1/2 and in turn, suppressed STAT3 phosphorylation to induce IL-8 expression in HCT116 cells, thus stimulating endothelial cell proliferation and tube like formation.	Lithocholic Acid	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
28883755-3	2017	Here, we demonstrate that hypoxia, reactive oxygen species (ROS), and differential concentration of glucose influence the expression of cytokines and chemokines, such as IL-6, IL-8, and IP-10, in human glial cell lines.	Reactive Oxygen Species	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
28652177-0	2017	Inhibition of IL-6 and IL-8 production in LPS-stimulated human gingival fibroblasts by glycyrrhizin via activating LXRalpha.	Glycyrrhizic Acid	87-99	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
28883755-3	2017	Here, we demonstrate that hypoxia, reactive oxygen species (ROS), and differential concentration of glucose influence the expression of cytokines and chemokines, such as IL-6, IL-8, and IP-10, in human glial cell lines.	Glucose	100-107	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
28652177-5	2017	The results showed that glycyrrhizin significantly inhibited LPS-induced IL-6 and IL-8 production, as well as COX-2 and iNOS expression.	Glycyrrhizic Acid	24-36	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
28652177-8	2017	In addition, the inhibition of glycyrrhizin on IL-6 and IL-8 production was reversed by LXRalpha inhibitor GGPP.	Glycyrrhizic Acid	31-43	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
28883755-4	2017	Treatment with cobalt chloride (CoCl2) and hydrogen peroxide (H2O2) significantly increased the expression levels of IL-6, IL-8, and IP-10 in a dose-dependent manner in CRT-MG and U251-MG astroglioma cells, but not in microglia cells.	cobaltous chloride	15-30	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
28883755-4	2017	Treatment with cobalt chloride (CoCl2) and hydrogen peroxide (H2O2) significantly increased the expression levels of IL-6, IL-8, and IP-10 in a dose-dependent manner in CRT-MG and U251-MG astroglioma cells, but not in microglia cells.	cobaltous chloride	32-37	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
28883755-4	2017	Treatment with cobalt chloride (CoCl2) and hydrogen peroxide (H2O2) significantly increased the expression levels of IL-6, IL-8, and IP-10 in a dose-dependent manner in CRT-MG and U251-MG astroglioma cells, but not in microglia cells.	Hydrogen Peroxide	43-60	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
28883755-4	2017	Treatment with cobalt chloride (CoCl2) and hydrogen peroxide (H2O2) significantly increased the expression levels of IL-6, IL-8, and IP-10 in a dose-dependent manner in CRT-MG and U251-MG astroglioma cells, but not in microglia cells.	Hydrogen Peroxide	62-66	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
28713935-10	2017	ELISA analysis demonstrated that curcumin reduced PM2.5-induced oxLDL, TNF-alpha and IL-8 levels.	Curcumin	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
28161237-5	2017	Here we report that LMWHs induce a profound change in the ability of human neutrophils to generate NETs and to mobilize the content of the primary granules in response to unrelated inflammatory stimuli, such as IL-8, PMA and HMGB1.	Heparin, Low-Molecular-Weight	20-25	C-X-C motif chemokine ligand 8	Homo sapiens	211-215
28958187-9	2017	At 6 h, n-Zn, b-Zn and n-Ag induced various immunity related genes associating to pattern recognition (including toll-like receptor), macrophage maturation, inflammatory response (TNF and IL-1beta), chemotaxis (CXCL8) and leucocyte migration (CXCL2-3 and CXCL14).	n-zn	8-12	C-X-C motif chemokine ligand 8	Homo sapiens	211-216
28958187-9	2017	At 6 h, n-Zn, b-Zn and n-Ag induced various immunity related genes associating to pattern recognition (including toll-like receptor), macrophage maturation, inflammatory response (TNF and IL-1beta), chemotaxis (CXCL8) and leucocyte migration (CXCL2-3 and CXCL14).	b-zn	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	211-216
28958187-9	2017	At 6 h, n-Zn, b-Zn and n-Ag induced various immunity related genes associating to pattern recognition (including toll-like receptor), macrophage maturation, inflammatory response (TNF and IL-1beta), chemotaxis (CXCL8) and leucocyte migration (CXCL2-3 and CXCL14).	Acetylglucosamine	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	211-216
28878857-0	2017	Unusual Soft Tissue Uptake of F-18 Sodium Fluoride in Three Patients Undergoing F-18 NaF PET/CT Bone Scans for Prostate Cancer.	Fluorine-18	30-34	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
28878857-0	2017	Unusual Soft Tissue Uptake of F-18 Sodium Fluoride in Three Patients Undergoing F-18 NaF PET/CT Bone Scans for Prostate Cancer.	Sodium Fluoride	35-50	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
28723715-1	2017	BACKGROUND: Fluorine-18-sodium fluoride (F-NaF) PET/CT is an important tool for detecting and evaluating metastatic bone cancer.	fluorine-18-sodium fluoride	12-39	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
28734155-6	2017	The mTOR inhibitor rapamycin (100nM) could attenuate the elevated expression of TF and IL-8.	Sirolimus	19-28	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
28459633-6	2017	DOX would add up stimulation of CMPK1 by DTT and overcome inhibition of CMPK1 by NaF, EDTA.	Doxorubicin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
28860481-8	2017	In conclusion, Siglec-9 was complementarily increased to induce a negative feedback loop to limit neutrophil activation in COPD, sSiglce-9 enhanced neutrophil ROS and chemotaxis toward IL-8 likely via competitively inhibiting ligands binding to Siglec-9.	ssiglce-9	129-138	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
28836948-3	2017	Previous studies have shown that IL-8 expression is induced by pneumococcal virulence factors (e.g. pneumolysin, peptidoglycan-polysaccharides, pneumococcal surface protein A (PspA) etc.	peptidoglycan-polysaccharides	113-142	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
28284032-3	2017	Recently, Greiner introduced the Vacuette  FC-Mix NaF-EDTA-citrate tube, currently the only NaF-citrate tube without volume-disturbing liquid additions available on the European market.	edta citrate	54-66	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
28711657-5	2017	Kaempferol decreased the production and mRNA expression of pro-inflammatory cytokines, in this case thymic stromal lymphopoietin (TSLP), IL-1beta, tumor necrosis factor (TNF)-alpha, and IL-8.	kaempferol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
28711657-7	2017	Kaempferol also ameliorated the lipopolysaccharide-induced production of the inflammatory mediators TSLP, IL-1beta, TNF-alpha, IL-8, and nitric oxide of macrophage-like cells differentiated by IL-32.	kaempferol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
28835236-7	2017	Interleukin-8 (IL-8) production by undifferentiated and differentiated Caco-2 cells following exposure to CuO NMs and CuSO4 was determined using an ELISA.	cuo nms	106-113	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
28741944-2	2017	To analyze how UGGT recognizes non-native glycoproteins, we chemically synthesized site-specifically 15N-labeled interleukin 8 (IL-8) C-terminal (34-72) glycopeptides bearing a Man9GlcNAc2 (M9) oligosaccharide.	15n	101-104	C-X-C motif chemokine ligand 8	Homo sapiens	113-126
28835236-7	2017	Interleukin-8 (IL-8) production by undifferentiated and differentiated Caco-2 cells following exposure to CuO NMs and CuSO4 was determined using an ELISA.	cuo nms	106-113	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
28741944-2	2017	To analyze how UGGT recognizes non-native glycoproteins, we chemically synthesized site-specifically 15N-labeled interleukin 8 (IL-8) C-terminal (34-72) glycopeptides bearing a Man9GlcNAc2 (M9) oligosaccharide.	15n	101-104	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
28741944-2	2017	To analyze how UGGT recognizes non-native glycoproteins, we chemically synthesized site-specifically 15N-labeled interleukin 8 (IL-8) C-terminal (34-72) glycopeptides bearing a Man9GlcNAc2 (M9) oligosaccharide.	Glycopeptides	153-166	C-X-C motif chemokine ligand 8	Homo sapiens	113-126
28835236-15	2017	CONCLUSIONS: CuO NMs and CuSO4 stimulated IL-8 production by Caco-2 cells, decreased barrier integrity and thereby increased the Papp and translocation of Cu.	Copper Sulfate	25-30	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
28741944-2	2017	To analyze how UGGT recognizes non-native glycoproteins, we chemically synthesized site-specifically 15N-labeled interleukin 8 (IL-8) C-terminal (34-72) glycopeptides bearing a Man9GlcNAc2 (M9) oligosaccharide.	Glycopeptides	153-166	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
28835236-15	2017	CONCLUSIONS: CuO NMs and CuSO4 stimulated IL-8 production by Caco-2 cells, decreased barrier integrity and thereby increased the Papp and translocation of Cu.	Copper	13-15	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
28624457-8	2017	The enhanced release of interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) by the THP-1 macrophages suggested that the needle-shaped CaCO3 particles trigger a pro-inflammatory response.	Calcium Carbonate	147-152	C-X-C motif chemokine ligand 8	Homo sapiens	24-37
28643827-7	2017	We also studied the effect of sulfated alginate on the ability of IL-1beta to stimulate inflammatory genes in human chondrocytes and found decreased expression of the pro-inflammatory markers IL-6 and CXCL8, which inversely correlated with the sulfation degree.	Alginates	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	201-206
28829835-5	2017	We furthermore show that vemurafenib and trametinib abrogated the activity of ERK1/2, arrested cells in G0/G1 cell cycle phase, triggered apoptosis, induced changes in the expression of CXCL8, CCND1 and CTGF and the frequency of Ki-67high and CD271high cells.	Vemurafenib	25-36	C-X-C motif chemokine ligand 8	Homo sapiens	186-191
28829835-5	2017	We furthermore show that vemurafenib and trametinib abrogated the activity of ERK1/2, arrested cells in G0/G1 cell cycle phase, triggered apoptosis, induced changes in the expression of CXCL8, CCND1 and CTGF and the frequency of Ki-67high and CD271high cells.	trametinib	41-51	C-X-C motif chemokine ligand 8	Homo sapiens	186-191
28624457-8	2017	The enhanced release of interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) by the THP-1 macrophages suggested that the needle-shaped CaCO3 particles trigger a pro-inflammatory response.	Calcium Carbonate	147-152	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
28532672-1	2017	In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs).	Catechin	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
28819180-5	2017	In NP cells, thrombin caused an increase in phosphorylation of the EGFR at the Tyr1068, and treatment with the pharmacological EGFR inhibitor, AG1473 effectively blocked thrombin-enhanced CXCL8 production.	ag1473	143-149	C-X-C motif chemokine ligand 8	Homo sapiens	188-193
28532672-1	2017	In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs).	epigallocatechin gallate	59-63	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
28532672-1	2017	In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs).	gallocatechol	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
28532672-1	2017	In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1beta signaling pathway which regulates the expression of pro-inflammatory mediators (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs).	ec	74-76	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
28532672-2	2017	EGCG and EGC inhibited IL-6, IL-8, and MMP-2 production and selectively inhibited Cox-2 expression.	epigallocatechin gallate	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
28532672-2	2017	EGCG and EGC inhibited IL-6, IL-8, and MMP-2 production and selectively inhibited Cox-2 expression.	gallocatechol	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
28535933-11	2017	Additional ex vivo studies confirmed reduced induction of IL-6 (P = 0.017) and CXCL8/IL-8 (P = 0.005) with azithromycin.	Azithromycin	107-119	C-X-C motif chemokine ligand 8	Homo sapiens	79-84
28811543-0	2017	4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol} (TIMBD) suppresses HIV1-gp120 mediated production of IL6 and IL8 but not CCL5.	4-(E)-((p-tolylimino)-methylbenzene-1,2-diol)	0-44	C-X-C motif chemokine ligand 8	Homo sapiens	107-110
28328096-7	2017	Tri-DAP further increased IL-8 secretion from DSCs via JNK pathway and facilitated both MMP-2 production and trophoblast invasion compared with control.	L-Ala-gamma-D-Glu-meso-diaminopimelic acid	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
28535933-11	2017	Additional ex vivo studies confirmed reduced induction of IL-6 (P = 0.017) and CXCL8/IL-8 (P = 0.005) with azithromycin.	Azithromycin	107-119	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
28369741-6	2017	Baricitinib decreased the rate of chemotaxis towards interleukin (IL)-8, but not f-Met-Leu-Phe (fMLP) in RA neutrophils.	baricitinib	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	53-71
28528743-1	2017	BACKGROUND AND AIMS: We aimed at evaluating the relation of 18F-sodium fluoride (18F-NaF) uptake on positron emission tomography (PET) to coronary atherosclerosis detected and assessed by computed tomography (CT).	18f-sodium fluoride	60-79	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
28528743-4	2017	Focal 18F-NaF uptake of each lesion was quantified using maximum tissue-to-background ratio (TBRmax).	tbrmax	93-99	C-X-C motif chemokine ligand 8	Homo sapiens	10-13
28554732-6	2017	However, atorvastatin treatment resulted in an improved St. Georges Respiratory Questionnaire (-5.62 points; P = .016) and reduced serum levels of CXCL8 (P = .04), tumor necrosis factor (P = .01), and intercellular adhesion molecule 1 (P = .04).	Atorvastatin	9-21	C-X-C motif chemokine ligand 8	Homo sapiens	147-152
28585102-7	2017	PGE2 has been shown to stimulate interleukin-8, an inflammatory cytokine that promotes the influx of neutrophils and induces remodeling of the cervical extracellular matrix, and to induce functional progesterone withdrawal.	Dinoprostone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	33-46
28371087-9	2017	Gene expressions of inflammatory markers IL-8 and MCP1 were reduced after clopidogrel treatment (P&lt;.05); however, only MCP-1 remained reduced at protein level.	Clopidogrel	74-85	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
28639412-4	2017	MATERIALS AND METHODS: The expression pattern of IL-8, TIMP-1, AP-1 transcription factor-Fra2 and ROS induction in peripheral blood monocytes following DZNep (histone methyltransferase inhibitor) and TLR8 agonist stimulation was investigated.	3-deazaneplanocin	152-157	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
28646302-9	2017	Interleukin (IL)-1beta, IL-6, IL-8 and IL-10 levels in the serum all increased POST-1h (P &gt; 0.05) but returned to pre-exercise levels POST-1d.	Hydrogen	84-86	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
28485095-9	2017	CONCLUSIONS: Overall, taking myo-inositol, compared with metformin, for 12 weeks in patients with PCOS with hyperinsulinism and normoinsulinism had beneficial effects on total testosterone, mFG scores, serum hs-CRP levels and gene expression of IL-1, but did not affect other hormonal profiles, NO levels or gene expression of IL-8 and TNF-alpha.	Inositol	29-41	C-X-C motif chemokine ligand 8	Homo sapiens	327-331
28349280-12	2017	PET/CT using 18F-NaF may be able to predict calcium score progression which is known to be the major characteristic of atherosclerosis.	Calcium	44-51	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
27295033-8	2017	RESULTS: In comparison with PGOS, FOS and inulin, VGOS showed the most pronounced protective effect on the DON-induced impairment of the monolayer integrity, acceleration of the tight junction reassembly and the subsequent CXCL8 release.	deoxynivalenol	107-110	C-X-C motif chemokine ligand 8	Homo sapiens	223-228
28853522-11	2017	The addition of vitamin D significantly down-regulated IL6 and IL8 secretion and up-regulated ADAMST13 expression.	Vitamin D	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
28349280-6	2017	We then evaluated the relationship between 18F-NaF uptake (using the maximum target-to-background ratio, TBRmax, and the maximum blood-subtracted 18F-NaF activity, bsNaFmax, which was obtained by subtracting the SUVmax of each calcified plaque lesion and NaF-avid site from the SUVmean in the right atrium blood pool) and the change in calcified plaque volume and characteristics obtained after 1 year.	Fluorine-18	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
28349280-8	2017	18F-NaF uptake showed very weak correlations with CTmax, CTmean, CVS, CVS after 1 year, AU and AU after 1 year on both baseline and follow-up PET/CT scans for each site.	ctmax	50-55	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
28349280-8	2017	18F-NaF uptake showed very weak correlations with CTmax, CTmean, CVS, CVS after 1 year, AU and AU after 1 year on both baseline and follow-up PET/CT scans for each site.	ctmean	57-63	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
28349280-8	2017	18F-NaF uptake showed very weak correlations with CTmax, CTmean, CVS, CVS after 1 year, AU and AU after 1 year on both baseline and follow-up PET/CT scans for each site.	Gold	88-90	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
28349280-8	2017	18F-NaF uptake showed very weak correlations with CTmax, CTmean, CVS, CVS after 1 year, AU and AU after 1 year on both baseline and follow-up PET/CT scans for each site.	Gold	95-97	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
28349280-11	2017	CONCLUSION: 18F-NaF uptake has a strong correlation with calcium score progression which was a predictor of future cardiovascular disease risk.	Calcium	57-64	C-X-C motif chemokine ligand 8	Homo sapiens	16-19
28969290-3	2017	AIM: The aim of this study was to assess and compare the efficacy of iontophoresis with 0.33% Sodium Fluoride (NaF) gel and diode laser alone in dentinal tubule occlusion.	Sodium Fluoride	94-109	C-X-C motif chemokine ligand 8	Homo sapiens	111-114
28577438-5	2017	The effects of SchB on TNF-alpha and IL-8 production were detected by ELISA.	schizandrin B	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
28577438-6	2017	The results showed that SchB strongly suppressed the production of TNF-alpha and IL-8 in HUVECs stimulated with LPS.	schizandrin B	24-28	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
27925206-5	2017	Consistent with this mechanism, GSH depletion and hypoxia also increased ASC secretion of VEGF, IL-8, leptin, Angiopoitein-2, and PDGF-BB.	Glutathione	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
28600799-5	2017	We found that PDMCs significantly reduced cardiomyocyte apoptosis and ROS production through the paracrine factors GRO-alpha, HGF and IL-8.	pdmcs	14-19	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
28577438-10	2017	And the inhibition of TNF-alpha and IL-8 production by SchB was blocked by transfection with Nrf2 siRNA.	schizandrin B	55-59	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
28371277-7	2017	The miR-138 mimic and LY294002 groups showed decreased concentrations of TNF-alpha, IL-6, IL-8 and NO and reduced activities of LDH and eNOS, while opposite trends were observed in the miR-138 inhibitor group.	mir-138	4-11	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
28371277-7	2017	The miR-138 mimic and LY294002 groups showed decreased concentrations of TNF-alpha, IL-6, IL-8 and NO and reduced activities of LDH and eNOS, while opposite trends were observed in the miR-138 inhibitor group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
28932561-8	2017	The concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-2R, IL-6, IL-8 and IL-10 in plasma on the first postoperative day significantly increased in the GAL group than in the non-GAL group (P&lt;0.05).	Galactose	177-180	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
28671329-8	2017	Moreover, OFE (1 to 100 mug/mL) showed a potent, dose-dependent inhibitory effect on H2 O2 -induced IL-8 secretion in WiDr cells.	Hydrogen Peroxide	85-90	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
28671329-10	2017	Of these compounds, 5 phenolic compounds-verbascoside, phillygenin, tyrosol, methyl 4-hydroxycinnamate, and eutigoside A-reduced IL-8 secretion at 10 mug/mL treatment concentrations.	phenolic	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
28671329-10	2017	Of these compounds, 5 phenolic compounds-verbascoside, phillygenin, tyrosol, methyl 4-hydroxycinnamate, and eutigoside A-reduced IL-8 secretion at 10 mug/mL treatment concentrations.	acteoside	41-53	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
28671329-10	2017	Of these compounds, 5 phenolic compounds-verbascoside, phillygenin, tyrosol, methyl 4-hydroxycinnamate, and eutigoside A-reduced IL-8 secretion at 10 mug/mL treatment concentrations.	phillygenin	55-66	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
28671329-10	2017	Of these compounds, 5 phenolic compounds-verbascoside, phillygenin, tyrosol, methyl 4-hydroxycinnamate, and eutigoside A-reduced IL-8 secretion at 10 mug/mL treatment concentrations.	4-hydroxyphenylethanol	68-75	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
28671329-10	2017	Of these compounds, 5 phenolic compounds-verbascoside, phillygenin, tyrosol, methyl 4-hydroxycinnamate, and eutigoside A-reduced IL-8 secretion at 10 mug/mL treatment concentrations.	protocatechuic acid methyl ester	77-102	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
28671329-10	2017	Of these compounds, 5 phenolic compounds-verbascoside, phillygenin, tyrosol, methyl 4-hydroxycinnamate, and eutigoside A-reduced IL-8 secretion at 10 mug/mL treatment concentrations.	eutigoside A	108-120	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
28611093-4	2017	Danirixin is a competitive antagonist against CXCL8 in Ca2+-mobilization assays, with a KB (the concentration of antagonist that binds 50% of the receptor population) of 6.5 nM and antagonist potency (pA2) of 8.44, and is fully reversible in washout experiments over 180 minutes.	danirixin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	46-51
28247536-7	2017	The interaction between the telomeric repeat-containing RNA (TERRA) and PARP-1 stimulates the SASP, which was attenuated by 67.9% (illustrated by the case of IL8) by treatment with melatonin.	Melatonin	181-190	C-X-C motif chemokine ligand 8	Homo sapiens	158-161
28411127-0	2017	Preventing false-negatives in the in vitro skin sensitization testing of acid anhydrides using interleukin-8 release assays.	acid anhydrides	73-88	C-X-C motif chemokine ligand 8	Homo sapiens	95-108
28586015-4	2017	The results indicated that Met, UC-II, CS, MSM and AO slightly or moderately suppressed the IL-1beta-stimulated IL-8 production by human synovial MH7A cells.	Chondroitin Sulfates	39-41	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
28586015-5	2017	The same compounds further decreased the IL-8 level lowered by GlcN.	Glucosamine	63-67	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
28867672-8	2017	IL-8 secretion increased with flavor and nicotine, while TNFalpha, IL-1beta, IL-6, MIP-1alpha, MIP-1beta, and MCP-1 decreased after exposure to most flavors and nicotine.	Nicotine	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
28414142-9	2017	However, when we examine the effect of doxofylline on secretion of the interleukin 8 from ASM cells stimulated by tumour necrosis factor (an in vitro surrogate measure of inflammation), there was no repression of inflammation.	doxofylline	39-50	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
28411127-6	2017	Additionally, treatment of THP-1 cells with PAH and phthalic acid using LP dispersion medium for 5min resulted in a 32-fold increase in IL-8 release for PAH as compared with that in the vehicle control.	phthalic anhydride	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
28411127-6	2017	Additionally, treatment of THP-1 cells with PAH and phthalic acid using LP dispersion medium for 5min resulted in a 32-fold increase in IL-8 release for PAH as compared with that in the vehicle control.	phthalic acid	52-65	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
28411127-6	2017	Additionally, treatment of THP-1 cells with PAH and phthalic acid using LP dispersion medium for 5min resulted in a 32-fold increase in IL-8 release for PAH as compared with that in the vehicle control.	Mineral Oil	72-74	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
28411127-6	2017	Additionally, treatment of THP-1 cells with PAH and phthalic acid using LP dispersion medium for 5min resulted in a 32-fold increase in IL-8 release for PAH as compared with that in the vehicle control.	phthalic anhydride	153-156	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
28411127-8	2017	Similarly, using LP dispersion medium, trimellitic anhydride significantly increased IL-8 release was observed.	Mineral Oil	17-19	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
28773202-6	2017	Furthermore, the bio-composites that included bio-lignin at 0.1% have been able to modulate the expression of pro-inflammatory cytokines (Tumor Necrosis Factor-alpha, IL-1alpha, and IL8), lipopolysaccharide (LPS)-induced, and matrix metalloproteinases (MMPs) and human beta-defensin 2 (HBD-2) expression in HaCat cells, suggesting an anti-inflammatory and immunomodulatory role.	Lignin	50-56	C-X-C motif chemokine ligand 8	Homo sapiens	182-185
28756770-14	2017	Additionally, elevated RNF183 expression partly reduced the inhibitory effect of trametinib on IL-8 expression.	trametinib	81-91	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
28756770-16	2017	CONCLUSION: The RNF183-IL-8 axis is responsible for the resistance of CRC cells to the MEK1/2 inhibitor trametinib and may serve as a candidate target for combined therapy for CRC.	trametinib	104-114	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
28749642-0	2017	Combination Therapy with Low Copper Diet, Penicillamine and Gamma Knife Radiosurgery Reduces VEGF and IL-8 In Patients with Recurrent Glioblastoma Purpose: Vascular Endothelial Growth Factor (VEGF) and interleukin-8 (IL-8) appear important in tumor growth.	Copper	29-35	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
28749642-0	2017	Combination Therapy with Low Copper Diet, Penicillamine and Gamma Knife Radiosurgery Reduces VEGF and IL-8 In Patients with Recurrent Glioblastoma Purpose: Vascular Endothelial Growth Factor (VEGF) and interleukin-8 (IL-8) appear important in tumor growth.	Penicillamine	42-55	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
28749642-1	2017	Inthis study, we have investigated the effect of copper reduction along with gamma knife radiosurgery on IL-8 and VEGFin patients with recurrent glioblastoma multiforme (GBM).	Copper	49-55	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
28724795-8	2017	SAA and aliquots of LXA4loSAAhi BAL fluid induced IL-8 production by lung epithelial cells expressing ALX receptors, which was inhibited by coincubation with 15-epi-LXA4.	lipoxin A4	158-169	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
28947965-11	2017	Significantly, inhibition of the IL-8 signaling pathway by reparixin, an inhibitor of the IL-8 receptor, CXCR1/2, reduced MDA-MB-231 tumor growth and metastasis.	reparixin	59-68	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
28947965-11	2017	Significantly, inhibition of the IL-8 signaling pathway by reparixin, an inhibitor of the IL-8 receptor, CXCR1/2, reduced MDA-MB-231 tumor growth and metastasis.	reparixin	59-68	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
28703802-5	2017	It can also be diminished by IL8-neutralizing antibody or blockade of IL8 receptors CXCR1/2 with reparixin.	reparixin	97-106	C-X-C motif chemokine ligand 8	Homo sapiens	70-73
29798256-5	2017	The levels of IL-1beta, IL-8 and TNF-alpha in saliva were lower on the third day and fifth day (P&lt; 0.05).Conclusion:Applying Cetylpyridinium Chloride Buccal Tablets during perioperative period can effectively relieve postoperative pharyngeal pain and inflammatory response in patients with OSAHS.	cetylpyridinium chloride buccal	128-159	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
28288142-7	2017	Unbiased large-scale metabolomic analysis and transcriptome-wide mRNA expression profiling identified reduced levels of several metabolites of the amino sugar and nucleotide sugar metabolic pathways, including sialic acid N-acetylneuraminic acid (Neu5Ac), and downregulation of pro-oncogenic cytokines interleukin-6 and 8 (IL-6 and IL-8) as unexpected outcomes of SHMT1 loss.	Amino Sugars	147-158	C-X-C motif chemokine ligand 8	Homo sapiens	332-336
28288142-7	2017	Unbiased large-scale metabolomic analysis and transcriptome-wide mRNA expression profiling identified reduced levels of several metabolites of the amino sugar and nucleotide sugar metabolic pathways, including sialic acid N-acetylneuraminic acid (Neu5Ac), and downregulation of pro-oncogenic cytokines interleukin-6 and 8 (IL-6 and IL-8) as unexpected outcomes of SHMT1 loss.	N-Acetylneuraminic Acid	210-221	C-X-C motif chemokine ligand 8	Homo sapiens	332-336
28288142-9	2017	Supplementation of culture medium with Neu5Ac stimulated expression of IL-6 and IL-8 and rescued the tumor growth and migratory phenotypes of ovarian cancer cells expressing SHMT1 shRNAs.	N-Acetylneuraminic Acid	39-45	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
30090537-5	2017	The mRNA levels of IL-6, IL-8, TNF-alpha and IL-1beta were upregulated by SiO2 NP or cold exposure, and more so in the combined group.	sio2 np	74-81	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
28347830-7	2017	RESULTS: In human keratinocytic HaCaT cells, PS extract inhibited the production of IL-8, and TARC, which had been increased by TNF-alpha and IFN-gamma.	ps	45-47	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
30090537-6	2017	The expressions of the proinflammatory cytokine genes IL-6, IL-8, TNF-alpha and IL-1beta increased highly significantly (P &lt; 0.01) in the SiO2 NP alone group and the combined group, compared with the control.	sio2 np	141-148	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
28369685-5	2017	Effects of isorhapontigenin and resveratrol on the release of IL-6 and chemokine (C-X-C motif) ligand 8 (CXCL8), and the activation of NF-kappaB, activator protein-1 (AP-1), MAPKs and PI3K/Akt/FoxO3A pathways were determined and compared with those of dexamethasone.	Resveratrol	32-43	C-X-C motif chemokine ligand 8	Homo sapiens	105-110
28643288-6	2017	H2O2 treatment increased both the protein and mRNA levels of IL-1beta, IL-8, and TNF-alpha, as well as those of SAPK/JNK.	Hydrogen Peroxide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
28643288-8	2017	In summary, the PAR2 antagonist peptide, FSLLRY-NH2, reduces the level of the pro-inflammatory genes IL-8, IL-1beta, and TNF-alpha induced by H2O2, through the SAPK/JNK pathways in HepG2 cells.	Hydrogen Peroxide	142-146	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
28229451-5	2017	RESULTS: Honokiol at 10 mum reduced IL-1alpha production by 3.4 folds (P &lt; 0.05) and at 10 and 20 mum reduced IL-8 by 23.9% and 53.1% (P &lt; 0.001), respectively, in HaCat keratinocytes.	honokiol	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
28176455-12	2017	Additionally, WZ4003 and SB203580 could suppress the APN-induced overexpression of CXCL1 and CXCL8.	WZ4003	14-20	C-X-C motif chemokine ligand 8	Homo sapiens	93-98
28176455-12	2017	Additionally, WZ4003 and SB203580 could suppress the APN-induced overexpression of CXCL1 and CXCL8.	SB 203580	25-33	C-X-C motif chemokine ligand 8	Homo sapiens	93-98
28220523-9	2017	Palmitic acid also up-regulated interleukin-8 (a key chemokine for human neutrophil recruitment) expression in human hepatocytes, which was attenuated and enhanced by cotreatment with a PPARgamma agonist and antagonist, respectively.	Palmitic Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	32-45
28534957-6	2017	Pretreatment with GSP before LPS treatment significantly suppressed the mRNA expression of pro-inflammatory cytokines such as IL-1beta, IL-6 and IL-8.	Grape Seed Proanthocyanidins	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
28671563-5	2017	The results showed that I3C and DIM pretreatment, at higher concentrations of 50 and 10 muM, respectively, significantly increased PMA/ionomycin-induced interleukin-2 (IL-2), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) production, measured by real time polymerase chain reaction (RT-PCR) and enzyme linked immunosorbent assay (ELISA).	Ionomycin	135-144	C-X-C motif chemokine ligand 8	Homo sapiens	175-188
28671563-5	2017	The results showed that I3C and DIM pretreatment, at higher concentrations of 50 and 10 muM, respectively, significantly increased PMA/ionomycin-induced interleukin-2 (IL-2), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) production, measured by real time polymerase chain reaction (RT-PCR) and enzyme linked immunosorbent assay (ELISA).	Ionomycin	135-144	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
28099236-9	2017	After 3 days, perfluorohexane treatment significantly (P &lt; .05) increased lung dynamic compliance, and reduced alveolar-arterial oxygen gradient, Acute Physiology and Chronic Health Evaluation II score, percentage of neutrophils, and levels of interleukin-6, interleukin-8, and tumor necrosis factor alpha in bronchoalveolar lavage fluid; there was no significant change in the control group before and after treatment.	perflexane	14-29	C-X-C motif chemokine ligand 8	Homo sapiens	262-275
29285030-10	2017	Resveratrol significantly inhibited LPS-induced IL-6 and IL-8 secretion by HGFs, but silymarin did not show such a significant effect.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
28369685-8	2017	KEY RESULTS: Isorhapontigenin concentration-dependently inhibited IL-6 and CXCL8 release, with IC50 values at least twofold lower than those of resveratrol.	isorhapontigenin	13-29	C-X-C motif chemokine ligand 8	Homo sapiens	75-80
28643000-0	2017	Interaction of the interleukin 8 protein with a sodium dodecyl sulfate micelle: A computer simulation study.	Sodium Dodecyl Sulfate	48-70	C-X-C motif chemokine ligand 8	Homo sapiens	19-32
27977904-0	2017	Adenosine triphosphate induces P2Y2 activation and interleukin-8 release in human esophageal epithelial cells.	Adenosine Triphosphate	0-22	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
27977904-3	2017	This study characterized and identified human esophageal epithelial P2 receptors that are responsible for ATP-mediated release of IL-8 by using a human esophageal stratified squamous epithelial model.	Adenosine Triphosphate	106-109	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
27977904-8	2017	RESULTS: Adenosine triphosphate-gamma-S induced IL-8 release through the P2Y2 receptor.	adenosine triphosphate-gamma-s	9-39	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
27977904-9	2017	A P2Y2 receptor antagonist but not a P2X3 receptor antagonist or a P2Y1 receptor antagonist blocked ATP-gamma-S-mediated IL-8 release.	adenosine 5'-O-(3-thiotriphosphate)	100-111	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
27977904-12	2017	Inhibition of extracellular signal-regulated kinase but not of protein kinase C blocked the ATP-mediated release of IL-8.	Adenosine Triphosphate	92-95	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
27977904-15	2017	ATP-induced IL-8 release maybe involved in the pathogenesis of refractory gastroesophageal reflux disease.	Adenosine Triphosphate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
28643000-2	2017	Simulations for an SDS micelle with an IL8 protein show that both aggregates, which were initially separated, eventually approach each other to form a single complex.	Sodium Dodecyl Sulfate	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
28643000-6	2017	Graphical Abstract Attachment of the interleukin 8 protein with a sodium dodecyl sulfate (SDS) micelle is given by the charged positive amino acids as indicated by the interaction of those amino acids with the SDS headgroups.	Sodium Dodecyl Sulfate	66-88	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
28643000-6	2017	Graphical Abstract Attachment of the interleukin 8 protein with a sodium dodecyl sulfate (SDS) micelle is given by the charged positive amino acids as indicated by the interaction of those amino acids with the SDS headgroups.	Sodium Dodecyl Sulfate	90-93	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
28643000-6	2017	Graphical Abstract Attachment of the interleukin 8 protein with a sodium dodecyl sulfate (SDS) micelle is given by the charged positive amino acids as indicated by the interaction of those amino acids with the SDS headgroups.	Sodium Dodecyl Sulfate	210-213	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
28412309-3	2017	In analogy to endogenous androgens, nandrolone induced a dose-related increase in RACK1 transcriptional activity and protein expression, resulting in increased LPS-induced IL-8 and TNF-alpha production and proliferation in THP-1 cells.	Nandrolone	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
28667247-10	2017	Compared with the other groups, the combination of Astragaloside and Baicalin more efficiently reduced IL-1beta, IL-8, and TNF-alpha levels in the LPS-induced MSCs model, and ERK inhibitor was capable of recovering the inflammatory effect.	astragaloside	51-64	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
28667247-10	2017	Compared with the other groups, the combination of Astragaloside and Baicalin more efficiently reduced IL-1beta, IL-8, and TNF-alpha levels in the LPS-induced MSCs model, and ERK inhibitor was capable of recovering the inflammatory effect.	baicalin	69-77	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
28356331-9	2017	Quiescent human prostate stroma exposed to genotoxic agents (e.g., mitoxantrone) in vivo resulted in significant upregulation (2.7- to 5.7-fold; P &lt;= 0.01) of growth factors and cytokines including IL1beta, MMP3, IL6, and IL8.	Mitoxantrone	67-79	C-X-C motif chemokine ligand 8	Homo sapiens	225-228
28670183-1	2017	We evaluated the association between serum prostate specific antigen (PSA) level and kinetics to predict 18F-sodium fluoride positron emission tomography-computed tomography (18F-NaF PET-CT) positivity for first bone metastases in men with biochemical recurrence after radical prostatectomy.	Sodium Fluoride	109-124	C-X-C motif chemokine ligand 8	Homo sapiens	179-182
28442557-5	2017	Incubation of cells in an HP (3.3 mM) medium caused an increased expression of the pro-inflammatory mediators intercellular adhesion molecule 1 (ICAM-1), interleukins (ILs) IL-1beta, IL-6, IL-8 and tumour necrosis factor alpha (TNF-alpha) (not corroborated at the protein levels for ICAM-1), as well as an increase in reactive oxygen/nitrogen species (ROS/RNS) production.	Hematoporphyrins	26-28	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
28392494-2	2017	First, the preparation of nanoparticles in the presence of sodium fluoride (NaF) as the active ingredient by ionic gelation was investigated followed by an evaluation of their drug entrapment and release properties.	Sodium Fluoride	59-74	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
28392494-5	2017	A steady increase in the fluoride release was observed for chitosan nanoparticles prepared in 0.2% NaF both in pH5 and 7 until it reached a maximum at time point 4h and maintained at this level for at least 24h.	Fluorides	25-33	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
28392494-6	2017	Similar profiles were observed for formulations prepared in 0.4% NaF; however the fluoride was released at a higher level at pH5.	Fluorides	82-90	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
28527783-9	2017	In addition, TIM-38 inhibited UDP-induced interleukin-8 release in a dose-dependent manner without affecting releases caused by other stimulus such as interleukin-1beta or tumour necrosis factor-alpha.	3-nitro-2-(trifluoromethyl)-2H-chromene	13-19	C-X-C motif chemokine ligand 8	Homo sapiens	42-55
28527783-9	2017	In addition, TIM-38 inhibited UDP-induced interleukin-8 release in a dose-dependent manner without affecting releases caused by other stimulus such as interleukin-1beta or tumour necrosis factor-alpha.	Uridine Diphosphate	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	42-55
28808406-9	2017	RESULTS: Peimine inhibited the production of pro-inflammatory cytokines, such as IL-6, IL-8, and TNF-alpha.	verticine	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
28808406-13	2017	SUMMARY: Peimine inhibited the production of pro-inflammatory cytokines, such as IL-6, IL-8, and TNF-alphaPeimine reduced MAPKs phosphorylation and the nuclear NF-kappaB expression in PMACI-induced HMC-1Peimine decreased PCA reactions in ratsPeimine has anti-allergic effect through regulation of pro-inflammatory mechanism on mast cell.	verticine	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
28665978-9	2017	Our results demonstrated testosterone not only suppressed the invasion and colonization of UPEC, but also inhibited the expression of pro-inflammatory IL-1beta, IL-6 and IL-8 cytokines expression induced by UPEC in a dose-dependent manner.	Testosterone	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
28730070-1	2017	AIM: To study the effects of curcumin on the secretion of interleukin (IL)-6 and IL-8 by corneal limbus epithelial cells.	Curcumin	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
28730070-8	2017	Various signal pathway inhibitors, including SP600125 (JNK inhibitor), SB203580 (p38 MAPK inhibitor) and BAY11-7082 (NF-kappaB inhibitor) significantly decreased the UVB-induced secretion of IL-6 and IL-8 secretion (P&lt;0.05).	3-(4-methylphenylsulfonyl)-2-propenenitrile	105-115	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
28730070-9	2017	Curcumin at 5-20 micromol/L significantly inhibited UVB-induced secretion of IL-6 and IL-8 by limbus epithelial cells in a dose-dependent manner; while curcumin alone did not affect the secretion of IL-6 and IL-8.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
28730070-9	2017	Curcumin at 5-20 micromol/L significantly inhibited UVB-induced secretion of IL-6 and IL-8 by limbus epithelial cells in a dose-dependent manner; while curcumin alone did not affect the secretion of IL-6 and IL-8.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
28730070-10	2017	The upregulation of NF-kappaB and MAPK pathways induced by UVB treatment was significantly inhibited by curcumin, suggesting that NF-kappaB and MAPK pathways are involved in the inhibitory effect of curcumin on UVB-induced production of IL-6 and IL-8.	Curcumin	104-112	C-X-C motif chemokine ligand 8	Homo sapiens	246-250
28730070-10	2017	The upregulation of NF-kappaB and MAPK pathways induced by UVB treatment was significantly inhibited by curcumin, suggesting that NF-kappaB and MAPK pathways are involved in the inhibitory effect of curcumin on UVB-induced production of IL-6 and IL-8.	Curcumin	199-207	C-X-C motif chemokine ligand 8	Homo sapiens	246-250
28418782-10	2017	Increased levels of p-Akt and decreased levels of FOXO3a protein expression suggested that reactive oxygen species played a role in the initiation and maintenance of senescence in IL-8-silenced PMSCs.	Reactive Oxygen Species	91-114	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
28606092-6	2017	In addition, we found an increase in the cytokine secretion of IL-6 and chemokine IL-8 in FFA-treated HC in comparison to the untreated HC.	Fatty Acids, Nonesterified	90-93	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
28614381-0	2017	The cytotoxic effect of TiF4 and NaF on fibroblasts is influenced by the experimental model, fluoride concentration and exposure time.	Fluorides	93-101	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
28600524-9	2017	In addition, cotinine and nicotine-cotinine mixture suppressed VEGF and IL-8 expression and upregulated TIMP-2 expression.	Cotinine	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
28664168-1	2017	This article contains the data showing illustrative examples of plaque classification on coronary computed tomography angiography (CCTA) and measurement of 18F-sodium fluoride (18F-NaF) uptake in coronary atherosclerotic lesions on positron emission tomography (PET).	18f-sodium fluoride	156-175	C-X-C motif chemokine ligand 8	Homo sapiens	181-184
28600524-9	2017	In addition, cotinine and nicotine-cotinine mixture suppressed VEGF and IL-8 expression and upregulated TIMP-2 expression.	Nicotine	26-34	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
28600524-9	2017	In addition, cotinine and nicotine-cotinine mixture suppressed VEGF and IL-8 expression and upregulated TIMP-2 expression.	Cotinine	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
28238270-6	2017	TMZ treatment led to a decrease in IL-2 concentrations before TET, as well as it prevented the increase of IL-8 following the second TET.	tet	133-136	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
28575053-8	2017	Treatment of HUVECs with U0126, an ERK1/2 signaling inhibitor, attenuated autocrine production of IL-8 induced by Mxi1-0 overexpression.	U 0126	25-30	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
28238270-0	2017	Effects of trimetazidine on interleukin-2 and interleukin-8 concentrations in patients with coronary artery disease.	Trimetazidine	11-24	C-X-C motif chemokine ligand 8	Homo sapiens	46-59
28238270-7	2017	Obtained results confirmed the improvement in TET performance during TMZ treatment and they revealed a significant influence of TMZ on IL-2 and IL-8 concentrations both before and after TET.	Trimetazidine	128-131	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
28238270-6	2017	TMZ treatment led to a decrease in IL-2 concentrations before TET, as well as it prevented the increase of IL-8 following the second TET.	Trimetazidine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
30087790-2	2017	Early events in inflammation involve the recruitment of neutrophils to the site of injury or damage where changes in intracellular calcium can cause the activation of pro-inflammatory mediators from neutrophils including superoxide generation, degranulation and release of myeloperoxidase (MPO), productions of interleukin (IL)-8 and tumor necrosis factor alpha (TNF-alpha), and adhesion to the vascular endothelium.	Calcium	131-138	C-X-C motif chemokine ligand 8	Homo sapiens	311-329
28317149-9	2017	CONCLUSION: In the PCPT finasteride arm, variation in genes involved in the immune response, including possibly IL8 and IL10 as in the placebo arm, may be associated with prostate cancer, especially higher-grade disease, but not with intraprostatic inflammation.	pcpt	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	112-115
28333279-14	2017	In human foetal membranes, PIM1 inhibitors SMI-4a and AZD1208 significantly decreased the expression of pro-inflammatory cytokine interleukin-6 (IL6) and chemokines CXCL8 and CCL2 mRNA and release, prostaglandin prostaglandin F2alpha (PGF2alpha) release, adhesion molecule intercellular adhesion molecule 1 mRNA expression and release, and oxidative stress marker 8-isoprostane release after stimulation with either LPS or flagellin.	AZD1208	54-61	C-X-C motif chemokine ligand 8	Homo sapiens	165-170
28317149-9	2017	CONCLUSION: In the PCPT finasteride arm, variation in genes involved in the immune response, including possibly IL8 and IL10 as in the placebo arm, may be associated with prostate cancer, especially higher-grade disease, but not with intraprostatic inflammation.	Finasteride	24-35	C-X-C motif chemokine ligand 8	Homo sapiens	112-115
29849682-4	2017	The level of serum IL-8 was compared between the glucocorticosteroid groups, receiving inhaled corticosteroids (ICs), oral corticosteroids (OCs), and intravenous corticosteroids (GCs), respectively.	glucocorticosteroid	49-68	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
29849682-4	2017	The level of serum IL-8 was compared between the glucocorticosteroid groups, receiving inhaled corticosteroids (ICs), oral corticosteroids (OCs), and intravenous corticosteroids (GCs), respectively.	Iron-Sulfur-Molybdenum Cluster With Interstitial Carbon	112-115	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
28214551-3	2017	The BAK effect at 10-4% or 5.10-3% on the gene expressions of interleukin-6 (IL-6), interleukin-8 (IL-8) and matrix metalloproteinase (MMP-9) was investigated using qRT-PCR in 2D and 3D p-hTMC cultures.	Benzalkonium Compounds	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
28214551-3	2017	The BAK effect at 10-4% or 5.10-3% on the gene expressions of interleukin-6 (IL-6), interleukin-8 (IL-8) and matrix metalloproteinase (MMP-9) was investigated using qRT-PCR in 2D and 3D p-hTMC cultures.	Benzalkonium Compounds	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
29849682-4	2017	The level of serum IL-8 was compared between the glucocorticosteroid groups, receiving inhaled corticosteroids (ICs), oral corticosteroids (OCs), and intravenous corticosteroids (GCs), respectively.	L-Cysteic acid	140-143	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
28214551-5	2017	IL-6 and IL-8 gene expressions increased in presence of BAK in 2D and in 3D p-hTMC cultures.	Benzalkonium Compounds	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
29849682-5	2017	Changes in the serum IL-8 level were compared between asthmatics with good and poor glucocorticosteroid responsiveness.	glucocorticosteroid	84-103	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
29849682-8	2017	The area under curve (AUC) for serum IL-8 level, indicative of uncontrolled asthma, was 0.816 (95% CI, 0.7605 to 0.8721; P&lt; 0.0001), which was greater than the AUC of fractional exhaled nitric oxide (AUC, 0.711; 95% CI, 0.6057 to 0.8153; P= .0188).	Nitric Oxide	189-201	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
29849682-13	2017	The change in IL-8 level also reflects the response to glucocorticosteroids in uncontrolled asthma.	glucocorticosteroids	55-75	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
28363866-9	2017	Transfection of poly(I-C) enhanced IL8 and BST2 mRNA expression and inhibited HBsAg secretion from PLC/PRF/5 cells.	Poly I-C	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
28539592-7	2017	Furthermore, atorvastatin was able to block the induction of interleukins IL-6 and IL-8 triggered by pathologic stimuli relevant to AMD, such as cholesterol crystals and ox-LDL.	Atorvastatin	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
28539592-7	2017	Furthermore, atorvastatin was able to block the induction of interleukins IL-6 and IL-8 triggered by pathologic stimuli relevant to AMD, such as cholesterol crystals and ox-LDL.	Cholesterol	145-156	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
28169521-8	2017	AY254, but not AY77 or DF253, attenuated cytokine-induced caspase 3/8 activation, promoted scratch-wound healing, and induced IL-8 secretion, all via PAR2-ERK1/2 signaling.	ay254	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
27821605-9	2017	Multivariate analyses identified IL6 and IL8 as independent predictors of OS.Conclusions: Foretinib demonstrated promising antitumor activity and good tolerability in the first-line setting in Asian advanced hepatocellular carcinoma patients.	GSK 1363089	90-99	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
28396316-7	2017	Neutralization studies identified IL-6 and CXCL8 as factors secreted by EVTs that induce endothelial cell CCL14 and CXCL6 expression.	evts	72-76	C-X-C motif chemokine ligand 8	Homo sapiens	43-48
28486961-6	2017	Heparin reduced the expression of pro-inflammatory markers (TNF-alpha and IL-6) in hAM and deactivated the NF-kss pathway in hATII, diminishing the expression of IRAK1 and MyD88 and their effectors, IL-6, MCP-1 and IL-8.	Heparin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
28487429-9	2017	Additional cytokine secretion screening identified molecules that induce levels of tumor necrosis factor alpha (TNF-alpha) and interleukin-8 (IL-8) comparable to the levels induced by phosphorylated hexa-acyl disaccharide (PHAD).	UNII-5A35GQS15R	223-227	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
28539656-3	2017	Here, we show that Tat-induced CXCL8 production is essentially dependent on the activation of PKC delta isoform, as shown a) by the capacity of PKC delta dominant negative (DN), and Rottlerin, a selective PKC delta pharmacological inhibitor, to inhibit Tat-induced CXCL8 production and b) by the ability of the constitutively active (CAT) isoform of PKC delta to induce CXCL8 production in a HEK cell line in the absence of Tat stimulation.	rottlerin	182-191	C-X-C motif chemokine ligand 8	Homo sapiens	31-36
28235736-6	2017	The receptor R is able to detect sodium salts of flouride (NaF) and acetate (NaAcO) in aqueous medium and it exhibited dramatic color change from pale yellow to red.	sodium salts	33-45	C-X-C motif chemokine ligand 8	Homo sapiens	59-62
28235736-6	2017	The receptor R is able to detect sodium salts of flouride (NaF) and acetate (NaAcO) in aqueous medium and it exhibited dramatic color change from pale yellow to red.	flouride	49-57	C-X-C motif chemokine ligand 8	Homo sapiens	59-62
28235736-6	2017	The receptor R is able to detect sodium salts of flouride (NaF) and acetate (NaAcO) in aqueous medium and it exhibited dramatic color change from pale yellow to red.	naaco	77-82	C-X-C motif chemokine ligand 8	Homo sapiens	59-62
29029391-6	2017	Down-regulation of interleukin 8 (IL-8) in a dose- and time-dependent manner was observed in ginsenoside Rg3-treated stromal cells, and over-expression or addition of IL-8 reversed the anti-senescence role of Rg3 in prostate stromal cells.	Ginsenosides	93-104	C-X-C motif chemokine ligand 8	Homo sapiens	19-32
29029391-0	2017	Ginsenoside Rg3 inhibits the senescence of prostate stromal cells through down-regulation of interleukin 8 expression.	Ginsenosides	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	93-106
29029391-6	2017	Down-regulation of interleukin 8 (IL-8) in a dose- and time-dependent manner was observed in ginsenoside Rg3-treated stromal cells, and over-expression or addition of IL-8 reversed the anti-senescence role of Rg3 in prostate stromal cells.	Ginsenosides	93-104	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
29029391-6	2017	Down-regulation of interleukin 8 (IL-8) in a dose- and time-dependent manner was observed in ginsenoside Rg3-treated stromal cells, and over-expression or addition of IL-8 reversed the anti-senescence role of Rg3 in prostate stromal cells.	Ginsenosides	93-104	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
29029391-7	2017	Furthermore, ginsenoside Rg3 down-regulated IL-8 expression by decreasing the reactive oxygen species level in prostatic stromal cells and reducing the transcriptional activity of IL-8 promoter by damping the transcription factors C/EBP beta and p65 binding to IL-8 promoter.	Ginsenosides	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
29029391-7	2017	Furthermore, ginsenoside Rg3 down-regulated IL-8 expression by decreasing the reactive oxygen species level in prostatic stromal cells and reducing the transcriptional activity of IL-8 promoter by damping the transcription factors C/EBP beta and p65 binding to IL-8 promoter.	Ginsenosides	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
29029391-7	2017	Furthermore, ginsenoside Rg3 down-regulated IL-8 expression by decreasing the reactive oxygen species level in prostatic stromal cells and reducing the transcriptional activity of IL-8 promoter by damping the transcription factors C/EBP beta and p65 binding to IL-8 promoter.	Ginsenosides	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
29029391-7	2017	Furthermore, ginsenoside Rg3 down-regulated IL-8 expression by decreasing the reactive oxygen species level in prostatic stromal cells and reducing the transcriptional activity of IL-8 promoter by damping the transcription factors C/EBP beta and p65 binding to IL-8 promoter.	Reactive Oxygen Species	78-101	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
29029391-8	2017	Our research revealed that ginsenoside Rg3 was able to inhibit prostate stromal cell senescence by down-regulating IL-8 expression.	Ginsenosides	27-38	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
28339192-8	2017	Using the optimized inverted ALI/postincubation procedure, pro-inflammatory immune responses, in terms of interleukin (IL)-8 promoter and nuclear factor kappa B (NFkappaB) activity, were observed within short time, i.e. One hour exposure to ALI-deposited CuO-NPs and 2.5 h postincubation.	ali	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	106-124
28429305-4	2017	Macrolide antibiotics have demonstrated great benefit when used for their anti-inflammatory or immunomodulatory properties, which include the blockage of pro-inflammatory cytokines, such as interleukin (IL)-8 and tumor necrosis factor-alpha (TNF-alpha).	macrolide antibiotics	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	190-208
28292012-4	2017	DEHP treatment also increased the expression of interleukin-6 (IL-6) and IL-8.	Diethylhexyl Phthalate	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
27639185-5	2017	VPA and lithium both induce significant down-regulation of group I CD1 expression and secretion of IL-6 during differentiation of human monocyte-derived immature DC, while they differ in the induction of CD83 and CD86 expression, secretion of IL-8, IL-10, and TNF-alpha.	Valproic Acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	243-247
28101945-8	2017	And using the erlotinib as an inhibitor of EGFR, we identified the erlotinib impaired the phosphorylation of EGFR, ERK1/2, acetylation of NF-kappaB proteins and decreased IL-8.	Erlotinib Hydrochloride	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
27798431-6	2017	RESULTS: We show that, in contrast to RAL, ritonavir treatment significantly increases mRNA expression levels of HO-1, IL-8, TNFalpha, CCL5, and MCP-1 in vitro in a dose-dependent manner.	Ritonavir	43-52	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
27917510-9	2017	N-acetyl-l-cysteine suppressed MeHg-induced activation of IL-6 and IL-8 mRNA expression in U937 macrophages, indicating the effectiveness of N-acetyl-l-cysteine as a therapeutic drug in MeHg-induced inflammation.	Acetylcysteine	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
27917510-9	2017	N-acetyl-l-cysteine suppressed MeHg-induced activation of IL-6 and IL-8 mRNA expression in U937 macrophages, indicating the effectiveness of N-acetyl-l-cysteine as a therapeutic drug in MeHg-induced inflammation.	Acetylcysteine	141-160	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
28101945-8	2017	And using the erlotinib as an inhibitor of EGFR, we identified the erlotinib impaired the phosphorylation of EGFR, ERK1/2, acetylation of NF-kappaB proteins and decreased IL-8.	Erlotinib Hydrochloride	67-76	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
27682001-6	2017	PFOA enhanced gene expression of several pro-inflammatory cytokines, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 by the activation of nuclear factor (NF)-kappaB in IgE-stimulated mast cells.	perfluorooctanoic acid	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
27639185-5	2017	VPA and lithium both induce significant down-regulation of group I CD1 expression and secretion of IL-6 during differentiation of human monocyte-derived immature DC, while they differ in the induction of CD83 and CD86 expression, secretion of IL-8, IL-10, and TNF-alpha.	Lithium	8-15	C-X-C motif chemokine ligand 8	Homo sapiens	243-247
27881328-8	2017	The alloy-exposed culture media tested contained sufficient stimulatory metal ions to induce detectable IL-8 production in THP-1 cells, except for the Ni-Cr and stainless steel exposed media.	Metals	72-77	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
28532624-6	2017	METHODS: The effects of AG-related compounds on H2O2-induced changes in intracellular Ca2+ concentrations, extracellular signal-regulated kinase (ERK) activation, and CXCL8 secretion were assessed using U937 cells.	Hydrogen Peroxide	48-52	C-X-C motif chemokine ligand 8	Homo sapiens	167-172
28532624-9	2017	CONCLUSION: Our results show that AG-related compounds inhibit H2O2-induced CXCL8 secretion following ERK activation, which is mediated by TRPM2-dependent and -independent mechanisms in U937 cells.	Hydrogen Peroxide	63-67	C-X-C motif chemokine ligand 8	Homo sapiens	76-81
27881328-9	2017	Au and Pd-Cu alloys were also most effective in potentiating LPS responsiveness as measured by IL-8 production.	Gold	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
27881328-9	2017	Au and Pd-Cu alloys were also most effective in potentiating LPS responsiveness as measured by IL-8 production.	pd-cu	7-12	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
27624778-0	2017	ROS-dependent HMGB1 secretion upregulates IL-8 in upper airway epithelial cells under hypoxic condition.	Reactive Oxygen Species	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
28288823-0	2017	Cadmium-induced IL-6 and IL-8 expression and release from astrocytes are mediated by MAPK and NF-kappaB pathways.	Cadmium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
28288823-3	2017	In the peripheral system, cadmium promotes interleukin-6 (IL-6) and IL-8 production and release.	Cadmium	26-33	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
28288823-12	2017	Pretreatment with U0126-an inhibitor of MEK1 and MEK2 kinases-SB203580-a p38 MAPK inhibitor-and SC-514-an IKKbeta inhibitor-suppressed cadmium-induced IL-8 expression and release.	SB 203580	62-70	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
28288823-6	2017	Herein, the effects of non-toxic concentrations of cadmium on the production of IL-6 and IL-8 and the underlying mechanisms were investigated.	Cadmium	51-58	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
28288823-12	2017	Pretreatment with U0126-an inhibitor of MEK1 and MEK2 kinases-SB203580-a p38 MAPK inhibitor-and SC-514-an IKKbeta inhibitor-suppressed cadmium-induced IL-8 expression and release.	Cadmium	135-142	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
28288823-15	2017	In conclusion, non-toxic concentrations of cadmium can stimulate IL-6 and IL-8 release through MAPK phosphorylation and NF-kappaB activation.	Cadmium	43-50	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
28288823-10	2017	IL-6 and IL-8 mRNA levels and secretion increased in dose- and time-dependent manners post cadmium exposure.	Cadmium	91-98	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
28288823-16	2017	Suppressing IL-6 and IL-8 production could be novel approaches to prevent cadmium-induced angiogenesis in gliomas and inflammation in the brain.	Cadmium	74-81	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
28288823-12	2017	Pretreatment with U0126-an inhibitor of MEK1 and MEK2 kinases-SB203580-a p38 MAPK inhibitor-and SC-514-an IKKbeta inhibitor-suppressed cadmium-induced IL-8 expression and release.	U 0126	18-23	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
28438162-12	2017	Comparably, the in vitro experiments showed that FK866 also inhibited IL-8 production and NF-kappaB activation in human alveolar epithelial cells exposed to H/R.	N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide	49-54	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
28496415-4	2017	We previously reported that exposure of human bronchial epithelial cells (HBECs) to non-menthol cigarette smoke extract (Non-M-CSE) triggers a cascade of inflammatory signaling leading to IL-8 induction.	Menthol	88-95	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
28438134-0	2017	Poly I:C induces collective migration of HaCaT keratinocytes via IL-8.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
28438134-8	2017	Poly I:C also increased IL-8 and bFGF production, and anti-IL-8 antibodies significantly inhibited the migration caused by poly I:C.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
28438134-8	2017	Poly I:C also increased IL-8 and bFGF production, and anti-IL-8 antibodies significantly inhibited the migration caused by poly I:C.	Poly I-C	123-131	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
28438134-12	2017	CONCLUSION: Our findings demonstrated that poly I:C accelerated collective HaCaT cell migration via autocrine/paracrine secretions of IL-8 and the subsequent incomplete epithelial-mesenchymal transition (EMT).	Poly I-C	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
28554966-9	2017	While PiC and CDCA increased IL-8 production, LCA reduced both basal and PiC +- CDCA-induced IL-8 production.	pic	6-9	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
28554966-9	2017	While PiC and CDCA increased IL-8 production, LCA reduced both basal and PiC +- CDCA-induced IL-8 production.	Chenodeoxycholic Acid	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
28554966-9	2017	While PiC and CDCA increased IL-8 production, LCA reduced both basal and PiC +- CDCA-induced IL-8 production.	Lithocholic Acid	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
28554966-9	2017	While PiC and CDCA increased IL-8 production, LCA reduced both basal and PiC +- CDCA-induced IL-8 production.	pic +	73-78	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
28554966-9	2017	While PiC and CDCA increased IL-8 production, LCA reduced both basal and PiC +- CDCA-induced IL-8 production.	Chenodeoxycholic Acid	80-84	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
28496415-10	2017	The activation of the MAPK/NF-kappaB signaling and induction of IL-8 to both CSE types were suppressed to similar levels by NAC, AMTB, or EGTA.	Acetylcysteine	124-127	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
28496415-10	2017	The activation of the MAPK/NF-kappaB signaling and induction of IL-8 to both CSE types were suppressed to similar levels by NAC, AMTB, or EGTA.	adenosylmethionine tosylate bis(sulfate)	129-133	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
28496415-10	2017	The activation of the MAPK/NF-kappaB signaling and induction of IL-8 to both CSE types were suppressed to similar levels by NAC, AMTB, or EGTA.	Egtazic Acid	138-142	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
28496415-12	2017	We also found that menthol combined with Non-M-CSE induced greater responses of intracellular Ca2+ and IL-8 compared with Non-M-CSE alone.	Menthol	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
28238931-0	2017	Effect of interleukin (IL)-8 on benzo[a]pyrene metabolism and DNA damage in human lung epithelial cells.	Benzo(a)pyrene	32-46	C-X-C motif chemokine ligand 8	Homo sapiens	10-28
28425504-5	2017	Mechanistically, chaetocin reduced the SUV39H1 and H3K9me3 levels in the native IL-8 promoter in normal HSAEpCs, which mimicked unstimulated COPD HSAEpCs and led to decreased HP-1alpha levels and increased RNA polymerase II levels.	chaetocin	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
28416823-15	2017	Using cDNA microarray we found that the expression of a panel of invasion/metastasis-related genes was significantly changed, including the increased expression of interleukin (IL)-8 and matrix metalloproteinase-3 (MMP-3) after ATP treatment.	Adenosine Triphosphate	228-231	C-X-C motif chemokine ligand 8	Homo sapiens	164-182
28238931-2	2017	To elucidate the role of the inflammatory cytokine IL-8 in this process, we studied its effect on the activation and deactivation of the chemical mutagen benzo[a]pyrene B[a]P in the immortalized pulmonary BEAS-2B cell line.	pyrene b	162-170	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
28238931-4	2017	Consistent with these findings, we observed higher concentration of the metabolite B[a]P-7,8-diol under concurrent IL-8 treatment conditions.	7,8-diol	89-97	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
28238931-6	2017	IL-8 lowered the intracellular NADPH level, but this effect could not explain the changes in B[a]P metabolism.	NADP	31-36	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
28238931-7	2017	IL-8 also significantly depleted intracellular glutathione (GSH), which also resulted in enhanced levels of unmetabolized B[a]P, but increased concentrations of the metabolite B[a]P-7,8-diol.	Glutathione	47-58	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
28238931-7	2017	IL-8 also significantly depleted intracellular glutathione (GSH), which also resulted in enhanced levels of unmetabolized B[a]P, but increased concentrations of the metabolite B[a]P-7,8-diol.	Glutathione	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
28238931-7	2017	IL-8 also significantly depleted intracellular glutathione (GSH), which also resulted in enhanced levels of unmetabolized B[a]P, but increased concentrations of the metabolite B[a]P-7,8-diol.	7,8-diol	182-190	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
28238931-9	2017	These findings suggest that IL-8 increased the formation of B[a]P-7,8-diol despite an overall delayed B[a]P metabolism via depletion of GSH, but DNA damage levels were unaffected due to an increase in NER capacity.	Benzo(a)pyrene	60-65	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
28238931-9	2017	These findings suggest that IL-8 increased the formation of B[a]P-7,8-diol despite an overall delayed B[a]P metabolism via depletion of GSH, but DNA damage levels were unaffected due to an increase in NER capacity.	7,8-diol	66-74	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
28238931-9	2017	These findings suggest that IL-8 increased the formation of B[a]P-7,8-diol despite an overall delayed B[a]P metabolism via depletion of GSH, but DNA damage levels were unaffected due to an increase in NER capacity.	Glutathione	136-139	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
28388885-9	2017	After pre-treatment with Cytochalasin D alone, IL-8 expression and JNK phosphorylation levels were not significantly different at 6 h but were significantly increased by approximately 1.2-fold (1.18 +- 0.05; P&lt;0.01) and 3.0-fold (3.01 +- 0.02; P&lt;0.01) at 24 h, respectively.	Cytochalasin D	25-39	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
28383530-9	2017	Decarine showed anti-inflammatory activity on human colon cells by reducing IL-6 and IL-8 production in TNF-alpha+IL-1beta-induced Caco-2 cells.	Decarine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
28772744-5	2017	Sodium fluoride (NaF), which has been widely used as a desensitizing agent, is regarded as positive control.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
28101847-1	2017	We have found that a well-characterized P2X7 receptor antagonist AZ11645373 blocked production of pro-inflammatory chemokine IL-8 in endothelial cells treated with OxPAPC.	AZ 11645373	65-75	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
28074216-6	2017	The results showed that increasing the concentration of ADO effectively restored the LPS-inhibited neutrophil chemotaxis to IL-8.	Adenosine	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
28052863-5	2017	Poly(I:C) increased the production of IL-6, IL-8, monocyte chemoattractant protein-1, and ICAM-1.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
28299617-6	2017	In particular, methyl caffeate down-regulated SASP factors such as IL-1alpha, IL-1beta, IL-6, IL-8, GM-CSF, CXCL1, MCP-2, and MMP-3.	methyl caffeate	15-30	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
27896541-4	2017	Gomisin N inhibited interleukin (IL)-6, IL-8, CC chemokine ligand (CCL) 2, and CCL20 production in TNF-alpha-stimulated HPDLC in a dose-dependent manner.	schizandrin B	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
28101847-1	2017	We have found that a well-characterized P2X7 receptor antagonist AZ11645373 blocked production of pro-inflammatory chemokine IL-8 in endothelial cells treated with OxPAPC.	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	164-170	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
28101847-6	2017	The inhibitory action of AZ11645373 was observed at the level of IL-8 protein and messenger RNA (mRNA) induction.	AZ 11645373	25-35	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
28101847-7	2017	Furthermore, AZ11645373 inhibited induction of mRNA encoding for COX-2 (PTGS2) suggesting that its anti-inflammatory potential is not limited to suppression of IL-8 production.	AZ 11645373	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
28101847-8	2017	In addition to inhibiting stimulation by OxPAPC, AZ11645373 suppressed induction of IL-8 by TNFalpha and LPS.	AZ 11645373	49-59	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
27397896-8	2017	RESULTS: High glucose stimulated a significant increase in the production of IL-6 and IL-8 by HGFs compared with normal glucose.	Glucose	14-21	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
28349908-11	2017	Miswak impregnated with 0.5% NaF resulted in a higher concentration of fluoride in saliva than brushing with 1450 ppm fluoride toothpaste.	Fluorides	71-79	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
28349908-12	2017	CLINICAL SIGNIFICANCE: Miswak impregnated with 0.5% NaF and toothbrushing results in comparable plaque removal and about the same fluoride concentration in saliva even it was somewhat higher for impregnated miswak.	Fluorides	130-138	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
27397896-10	2017	When both LPS and AGE-BSA were present, especially at high concentrations (&gt;= 500 mug/mL of LPS and &gt;= 25 mug/mL of AGE-BSA), a synergistic effect on IL-8 production was found in the high-glucose condition.	Glucose	194-201	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
27965148-4	2017	The up-regulation of ATF3 and IL-8, or DNAJB4 and GCLM induced by the representative sensitizer 2,4-dinitrochlorobenzene in human keratinocytes was significantly suppressed by a P2X7 specific antagonist KN-62, or by Nrf2 siRNA, respectively, which supported mechanistic relevance of marker genes.	Dinitrochlorobenzene	96-120	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
27397896-11	2017	CONCLUSIONS: A synergistic effect of the production of IL-8 could be induced in HGFs with the combination of high glucose, LPS and AGEs.	Glucose	114-121	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
28089818-9	2017	Enzyme-linked immunosorbent assay results revealed distinct differences in IL-6 and IL-8 secretions by NP cells in response to etoposide in the presence of NCCM.	Etoposide	127-136	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
28315997-6	2017	Ruminant TFA, including tVA, tPA and the mixture of tVA and tPA, significantly reduced the TNF-alpha-induced gene expression of TNF, VCAM-1 and SOD2 in HUVEC, as well as TNF and IL-8 in HepG2 cells.	Trans Fatty Acids	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
28315997-6	2017	Ruminant TFA, including tVA, tPA and the mixture of tVA and tPA, significantly reduced the TNF-alpha-induced gene expression of TNF, VCAM-1 and SOD2 in HUVEC, as well as TNF and IL-8 in HepG2 cells.	11-octadecenoic acid	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
28315997-6	2017	Ruminant TFA, including tVA, tPA and the mixture of tVA and tPA, significantly reduced the TNF-alpha-induced gene expression of TNF, VCAM-1 and SOD2 in HUVEC, as well as TNF and IL-8 in HepG2 cells.	palmitoleic acid	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
28315997-6	2017	Ruminant TFA, including tVA, tPA and the mixture of tVA and tPA, significantly reduced the TNF-alpha-induced gene expression of TNF, VCAM-1 and SOD2 in HUVEC, as well as TNF and IL-8 in HepG2 cells.	palmitoleic acid	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
28259918-2	2017	The plasmid vector containing CXCL8 cDNA was transfected into LoVo cells using Lipofectamine 2000 reagent.	lipofectamine 2000 reagent	79-105	C-X-C motif chemokine ligand 8	Homo sapiens	30-35
28078769-8	2017	IL-1alpha induced IL-8 in bronchial epithelial cells, which was dose-dependently inhibited by dexamethasone but not by azithromycin.	Dexamethasone	94-107	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
28078769-12	2017	We established an in vitro model wherein steroids inhibit the IL-1alpha-induced IL-8 production, while azithromycin was ineffective.	Steroids	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
30090515-7	2017	In addition, ATF2 knockdown did not decrease the expressions of pro-inflammatory cytokines induced by arsenite in SV-HUC-1 cells, but dramatically increased mRNA expressions of TNFalpha, TGFalpha and IL-8 under arsenite and non-arsenite conditions.	arsenite	211-219	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
30090515-7	2017	In addition, ATF2 knockdown did not decrease the expressions of pro-inflammatory cytokines induced by arsenite in SV-HUC-1 cells, but dramatically increased mRNA expressions of TNFalpha, TGFalpha and IL-8 under arsenite and non-arsenite conditions.	arsenite	211-219	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
28344983-10	2017	Challenge with bile acids at physiological levels also led to a significant increase in the release of IL-8 and IL6 from BEAS-2B.	Bile Acids and Salts	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
28167529-4	2017	Suppression or neutralization of vorinostat-induced IL-8/CXCL8 potentiates the vorinostat inhibitory effect on cell viability and proliferation.	Vorinostat	33-43	C-X-C motif chemokine ligand 8	Homo sapiens	57-62
28167529-4	2017	Suppression or neutralization of vorinostat-induced IL-8/CXCL8 potentiates the vorinostat inhibitory effect on cell viability and proliferation.	Vorinostat	79-89	C-X-C motif chemokine ligand 8	Homo sapiens	57-62
28167529-5	2017	The IL-8/CXCL8 expression induced by vorinostat in EOC cells is dependent on IkappaB kinase (IKK) activity and associated with a gene-specific recruitment of IKKbeta and IKK-dependent recruitment of p65 NFkappaB to the IL-8/CXCL8 promoter.	Vorinostat	37-47	C-X-C motif chemokine ligand 8	Homo sapiens	9-14
28167529-5	2017	The IL-8/CXCL8 expression induced by vorinostat in EOC cells is dependent on IkappaB kinase (IKK) activity and associated with a gene-specific recruitment of IKKbeta and IKK-dependent recruitment of p65 NFkappaB to the IL-8/CXCL8 promoter.	Vorinostat	37-47	C-X-C motif chemokine ligand 8	Homo sapiens	224-229
28345644-5	2017	Vitamin D had no effect on BEAS-2B cells but enhanced the production of IL-8 in neutrophils (p = 0.007) and IL-1beta in macrophages (p = 0.007) in response to LPS.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
28189686-0	2017	Interleukin-8 enhances the effect of colchicine on cell death.	Colchicine	37-47	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
28189686-6	2017	The effect of colchicine on cell death was enhanced in cells overexpressing IL-8.	Colchicine	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
28189686-7	2017	Moreover, the effect of colchicine on cell death was enhanced in cells overexpressing two IL-8 up-regulators, NF-kappaB and IL-6, but not in cells overexpressing an IL-8 down-regulator, splicing factor proline/glutamine-rich (SFPQ).	Colchicine	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
28189686-8	2017	Synergistic effects of IL-8 and colchicine were also observed in cells overexpressing IL-8 isoforms lacking the signal peptide.	Colchicine	32-42	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
28189686-9	2017	Therefore, IL-8 appeared to function as an enhancer of cell death in cancer cells treated with colchicine.	Colchicine	95-105	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
28278187-6	2017	Treatment with resveratrol significantly reduced the expression and secretion of pro-inflammatory cytokines IL-6, IL-1alpha, IL-1beta and pro-inflammatory chemokines IL-8 and MCP-1 in human placenta and omental and subcutaneous adipose tissue.	Resveratrol	15-26	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
28323848-7	2017	These results indicate that 7-oxygenated cholesterol derivatives have differential effects on monocyte/macrophage expression of IL-8 and C5a receptor and that C5a receptor is involved in 7alphaOHChol-induced IL-8 expression via PI3K and MEK.	Cholesterol	41-52	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
28323848-7	2017	These results indicate that 7-oxygenated cholesterol derivatives have differential effects on monocyte/macrophage expression of IL-8 and C5a receptor and that C5a receptor is involved in 7alphaOHChol-induced IL-8 expression via PI3K and MEK.	7alphaohchol	187-199	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
27997850-1	2017	Here a simple yet cost-effective strategy is developed to fabricate fluorine-doped graphene nanosheets, we successfully, prepared fluorine doped graphene via thermal treatment of graphene oxide and NaF (sodium fluoride) in H2SO4 solution phase.	Fluorine	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	198-201
27997850-1	2017	Here a simple yet cost-effective strategy is developed to fabricate fluorine-doped graphene nanosheets, we successfully, prepared fluorine doped graphene via thermal treatment of graphene oxide and NaF (sodium fluoride) in H2SO4 solution phase.	Graphite	83-91	C-X-C motif chemokine ligand 8	Homo sapiens	198-201
27997850-1	2017	Here a simple yet cost-effective strategy is developed to fabricate fluorine-doped graphene nanosheets, we successfully, prepared fluorine doped graphene via thermal treatment of graphene oxide and NaF (sodium fluoride) in H2SO4 solution phase.	fluorine doped	130-144	C-X-C motif chemokine ligand 8	Homo sapiens	198-201
27997850-1	2017	Here a simple yet cost-effective strategy is developed to fabricate fluorine-doped graphene nanosheets, we successfully, prepared fluorine doped graphene via thermal treatment of graphene oxide and NaF (sodium fluoride) in H2SO4 solution phase.	Graphite	145-153	C-X-C motif chemokine ligand 8	Homo sapiens	198-201
27997850-1	2017	Here a simple yet cost-effective strategy is developed to fabricate fluorine-doped graphene nanosheets, we successfully, prepared fluorine doped graphene via thermal treatment of graphene oxide and NaF (sodium fluoride) in H2SO4 solution phase.	Sodium Fluoride	203-218	C-X-C motif chemokine ligand 8	Homo sapiens	198-201
27997850-1	2017	Here a simple yet cost-effective strategy is developed to fabricate fluorine-doped graphene nanosheets, we successfully, prepared fluorine doped graphene via thermal treatment of graphene oxide and NaF (sodium fluoride) in H2SO4 solution phase.	sulfuric acid	223-228	C-X-C motif chemokine ligand 8	Homo sapiens	198-201
28323848-0	2017	7alpha-Hydroxycholesterol induces monocyte/macrophage cell expression of interleukin-8 via C5a receptor.	cholest-5-en-3 beta,7 alpha-diol	0-25	C-X-C motif chemokine ligand 8	Homo sapiens	73-86
28323848-2	2017	Transcript levels of IL-8 and secretion of its corresponding gene product by monocytes/macrophages were enhanced by treatment with 7alphaOHChol and, to a lesser extent, 7K, but not by 7betaOHChol.	7alphaohchol	131-143	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
28323848-2	2017	Transcript levels of IL-8 and secretion of its corresponding gene product by monocytes/macrophages were enhanced by treatment with 7alphaOHChol and, to a lesser extent, 7K, but not by 7betaOHChol.	7betaohchol	184-195	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
28323848-4	2017	7alphaOHChol-induced IL-8 gene transcription was inhibited by cycloheximide and Akt1 downregulation, but not by OxPAPC.	7alphaohchol	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
28323848-4	2017	7alphaOHChol-induced IL-8 gene transcription was inhibited by cycloheximide and Akt1 downregulation, but not by OxPAPC.	Cycloheximide	62-75	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
28323848-5	2017	Expression of C5a receptor was upregulated after stimulation with 7alphaOHChol, but not with 7K and 7betaOHChol, and a specific antagonist of C5a receptor inhibited 7alphaOHChol-induced IL-8 gene expression in a dose dependent manner.	7alphaohchol	66-78	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
28323848-5	2017	Expression of C5a receptor was upregulated after stimulation with 7alphaOHChol, but not with 7K and 7betaOHChol, and a specific antagonist of C5a receptor inhibited 7alphaOHChol-induced IL-8 gene expression in a dose dependent manner.	7alphaohchol	165-177	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
28323848-6	2017	Pharmacological inhibitors of PI3K and MEK almost completely inhibited expression of both IL-8 and cell-surface C5a receptor induced by 7alphaOHChol.	7alphaohchol	136-148	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
28323848-7	2017	These results indicate that 7-oxygenated cholesterol derivatives have differential effects on monocyte/macrophage expression of IL-8 and C5a receptor and that C5a receptor is involved in 7alphaOHChol-induced IL-8 expression via PI3K and MEK.	Cholesterol	41-52	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
28386331-4	2017	We devised this study to determine whether Hcy could affect the expression and secretion of VEGF and IL-8 from EPCs.	Homocysteine	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
28386331-5	2017	We found that high levels of Hcy (100-500 muM) decreased the EPC-mediated protein secretion and mRNA expression of VEGF and IL-8.	Homocysteine	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
28081470-7	2017	The expression level of cytokines and chemokines influenced by eleutheroside B1 was further demonstrated, the IL-6, CXCL-8, CCL-2 expression were all inhibited by the eleuthe roside B1 at concentration 200mug/ml.	Eleutheroside B1	63-79	C-X-C motif chemokine ligand 8	Homo sapiens	116-122
28003224-5	2017	We found that a corticosteroid (methylprednisolone) and an anti-VEGF agent (bevacizumab) prevented mCRP-induced ARPE-19 barrier disruption and IL-8 production.	Methylprednisolone	32-50	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
28337465-8	2017	Acetoin and diacetyl treatment induced IL-8 release in Beas2B cells.	Acetoin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
28337465-8	2017	Acetoin and diacetyl treatment induced IL-8 release in Beas2B cells.	Diacetyl	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
28337465-9	2017	Acetoin- and pentanedione-treated HFL-1 cells produced a differential, but significant response for IL-8 release compared to controls and TNFalpha.	Acetoin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
28337465-9	2017	Acetoin- and pentanedione-treated HFL-1 cells produced a differential, but significant response for IL-8 release compared to controls and TNFalpha.	acetylacetone	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
28337465-10	2017	Flavorings, such as ortho-vanillin and maltol, induced IL-8 release in Beas2B cells, but not in H292 cells.	vanillin	26-34	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
28337465-10	2017	Flavorings, such as ortho-vanillin and maltol, induced IL-8 release in Beas2B cells, but not in H292 cells.	maltol	39-45	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
28337465-11	2017	Of all the flavoring chemicals tested, acetoin and maltol were more potent inducers of IL-8 release than TNFalpha in Beas2B and HFL-1 cells.	Acetoin	39-46	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
28337465-11	2017	Of all the flavoring chemicals tested, acetoin and maltol were more potent inducers of IL-8 release than TNFalpha in Beas2B and HFL-1 cells.	maltol	51-57	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
28081470-7	2017	The expression level of cytokines and chemokines influenced by eleutheroside B1 was further demonstrated, the IL-6, CXCL-8, CCL-2 expression were all inhibited by the eleuthe roside B1 at concentration 200mug/ml.	eleuthe roside b1	167-184	C-X-C motif chemokine ligand 8	Homo sapiens	116-122
28013079-5	2017	We found that the responses of AP-1, BTG2, and IL8 biosensors in assessing the toxicity of silver nanoparticles (Ag NPs) showed good dose-related increases after exposure to Ag NPs and were consistent with data acquired by conventional assays, such as western blot, real-time polymerase chain reaction, and immunofluorescence.	Silver	91-97	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
27913196-10	2017	In addition, miR-155, IL-6, and IL-8 were over-expressed in the serum of arsenite exposure group.	arsenite	73-81	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
27651218-8	2017	RESULTS: After 12 weeks of rimonabant treatment, there was a significant increase in VEGF (99 2 +- 17 6 vs 116 2 +- 15 8 pg/ml, P &lt; 0 01) and IL-8 (7 4 +- 11 0 vs 18 1 +- 13 2 pg/ml, P &lt; 0 05) but not after metformin (VEGF P = 0 7; IL-8 P = 0 9).	Rimonabant	27-37	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
27651218-8	2017	RESULTS: After 12 weeks of rimonabant treatment, there was a significant increase in VEGF (99 2 +- 17 6 vs 116 2 +- 15 8 pg/ml, P &lt; 0 01) and IL-8 (7 4 +- 11 0 vs 18 1 +- 13 2 pg/ml, P &lt; 0 05) but not after metformin (VEGF P = 0 7; IL-8 P = 0 9).	Rimonabant	27-37	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
27651218-10	2017	CONCLUSION: This study suggests that rimonabant CB-I blockade paradoxically raised VEGF and the cytokine IL-8 in obese women with PCOS that may have offset the potential benefit associated with weight loss.	cobinamide	48-52	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
28314697-5	2017	Upon FXa stimulation, the expressions of pro-inflammatory genes such as monocyte chemoattractant protein-1 (MCP-1), intracellular adhesion molecule-1, and interleukin-8 were maximally increased at 4 h after stimulation, and were suppressed by rivaroxaban.	Rivaroxaban	243-254	C-X-C motif chemokine ligand 8	Homo sapiens	155-168
27719921-7	2017	Betalains dampened cyclooxygenase-2 and interleukin-8 mRNA expression after lipopolysaccharide induction in CaCo-2, showing an anti-inflammatory action.	Betalains	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
28204809-0	2017	Ketamine suppresses the substance P-induced production of IL-6 and IL-8 by human U373MG glioblastoma/astrocytoma cells.	Ketamine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
28204809-5	2017	The results from our experiments indicated that ketamine suppressed the production of interleukin (IL)-6 and IL-8 by the U373MG cells.	Ketamine	48-56	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
28204809-7	2017	Taken together, these observations suggest that ketamine may suppress the SP-induced activation (IL-6 and IL-8 production) of U373MG cells by inhibiting the phosphorylation of signaling molecules (namely ERK1/2, p38 MAPK and NF-kappaB), thereby exerting anti-inflammatory effects.	Ketamine	48-56	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
28454334-0	2017	Taxotere-induced elevated expression of IL8 in carcinoma-associated fibroblasts of breast invasive ductal cancer.	Docetaxel	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
26826259-7	2017	Glutamine, arginine, and vitamin D3, but not ALA, significantly attenuated IL-8 production.	Glutamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
26826259-7	2017	Glutamine, arginine, and vitamin D3, but not ALA, significantly attenuated IL-8 production.	Arginine	11-19	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
26826259-7	2017	Glutamine, arginine, and vitamin D3, but not ALA, significantly attenuated IL-8 production.	Cholecalciferol	25-35	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
26826259-9	2017	Combining glutamine, arginine, and curcumin at optimal concentrations completely abolished the IL-8 response.	Glutamine	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
26826259-9	2017	Combining glutamine, arginine, and curcumin at optimal concentrations completely abolished the IL-8 response.	Arginine	21-29	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
26826259-9	2017	Combining glutamine, arginine, and curcumin at optimal concentrations completely abolished the IL-8 response.	Curcumin	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
28454334-9	2017	Overall, elevated expression of IL8 induced by Taxotere in CAFs potentially supports the association between IL8 and chemotherapy response.	cafs	59-63	C-X-C motif chemokine ligand 8	Homo sapiens	109-112
28454334-8	2017	It was observed that the expression of the candidate gene IL8 in the CAFs of breast invasive cancer following treatment with Taxotere was increased (P&lt;0.05).	cafs	69-73	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
28454334-8	2017	It was observed that the expression of the candidate gene IL8 in the CAFs of breast invasive cancer following treatment with Taxotere was increased (P&lt;0.05).	Docetaxel	125-133	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
28454334-9	2017	Overall, elevated expression of IL8 induced by Taxotere in CAFs potentially supports the association between IL8 and chemotherapy response.	Docetaxel	47-55	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
28454334-9	2017	Overall, elevated expression of IL8 induced by Taxotere in CAFs potentially supports the association between IL8 and chemotherapy response.	Docetaxel	47-55	C-X-C motif chemokine ligand 8	Homo sapiens	109-112
28454334-9	2017	Overall, elevated expression of IL8 induced by Taxotere in CAFs potentially supports the association between IL8 and chemotherapy response.	cafs	59-63	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
27444775-7	2017	RESULTS: The gene expression and protein secretion of IL-8 in endometriotic stromal cells after incubation with lignocaine 0.1 mg/mL were significantly decreased after 24 hours compared to the controls ( P = .028 and P = .018).	Lidocaine	112-122	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
28087464-5	2017	Furthermore, the mitochondrial ROS scavenger Mito-TEMPO, which inhibited MAPK and AP-1, significantly reduced MCP-1 and IL-1beta mRNA expression and reduced HL-60 cell migration through the suppression of MCP-1 and IL-8 protein secretion.	Reactive Oxygen Species	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
29250282-6	2017	Results: Immediate post ablation levels of inflammatory cytokines were lower in the steroid group when compared to the placebo group; IL-6: 9.0 +-7 vs 15.8 +-13 p=0.031; IL-8: 10.5 +-9 vs 15.3 +-8; p=0.047 respectively.	Steroids	84-91	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
28106172-0	2017	Carrageenan activates monocytes via type-specific binding with interleukin-8: an implication for design of immuno-active biomaterials.	Carrageenan	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
28082672-5	2017	We show here that in both squamous cell carcinoma cells and melanoma tumor cells, CQ induced NF-kappaB activation and the expression of its target genes HIF-1alpha, IL-8, BCL-2, and BCL-XL through the accumulation of autophagosomes, p62, and JNK signaling.	Chloroquine	82-84	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
28230729-1	2017	Chlorogenic acid (CHA) and caffeic acid (CA) are phenolic compounds found in coffee, which inhibit oxidative stress-induced interleukin (IL)-8 production in intestinal epithelial cells, thereby suppressing serious cellular injury and inflammatory intestinal diseases.	caffeic acid	27-39	C-X-C motif chemokine ligand 8	Homo sapiens	124-142
28235416-8	2017	RESULTS: Pretreatment with low-dose (1 or 5 muM), long-term (72 h) CAM inhibited H2O2-induced IL-8 levels, NF-kappaB activity, and IL-8 mRNA expression, and improved the GSH/GSSG ratio via the maintenance of gamma-GCS expression levels.	Clarithromycin	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
28235416-8	2017	RESULTS: Pretreatment with low-dose (1 or 5 muM), long-term (72 h) CAM inhibited H2O2-induced IL-8 levels, NF-kappaB activity, and IL-8 mRNA expression, and improved the GSH/GSSG ratio via the maintenance of gamma-GCS expression levels.	Clarithromycin	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
28235416-8	2017	RESULTS: Pretreatment with low-dose (1 or 5 muM), long-term (72 h) CAM inhibited H2O2-induced IL-8 levels, NF-kappaB activity, and IL-8 mRNA expression, and improved the GSH/GSSG ratio via the maintenance of gamma-GCS expression levels.	Hydrogen Peroxide	81-85	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
28231837-8	2017	RESULTS: PBMCs from nAMD patients secreted higher levels of IL-8, CCL2 and VEGF, especially following LPS and 1% oxygen stimulation, than those from controls.	Oxygen	113-119	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
28260873-10	2017	COPD patients with CRS had a higher percentage of eosinophils, higher levels of IL-8, IL-6, and MMP-9 in sputum as compared to those without CRS.	3-cresol	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
28251074-8	2017	LPS at concentrations of 300 ng/mL for 1h significantly stimulated the mRNA expression of IL-8, IL-6, IL-1beta, TNF-alpha, and TGF-beta in HCECs, while the stimulation effects were significantly inhibited by AA (20 micromol/L).	Hydrogen	39-41	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
28055957-6	2017	Furthermore, 5-FU significantly induced c-Jun N-terminal kinase (JNK) activation and the expression of pro-inflammatory genes IL-8 and ICAM-1.	Fluorouracil	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
28230729-0	2017	Catechol Groups Enable Reactive Oxygen Species Scavenging-Mediated Suppression of PKD-NFkappaB-IL-8 Signaling Pathway by Chlorogenic and Caffeic Acids in Human Intestinal Cells.	catechol	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
28230729-0	2017	Catechol Groups Enable Reactive Oxygen Species Scavenging-Mediated Suppression of PKD-NFkappaB-IL-8 Signaling Pathway by Chlorogenic and Caffeic Acids in Human Intestinal Cells.	Reactive Oxygen Species	23-46	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
28230729-0	2017	Catechol Groups Enable Reactive Oxygen Species Scavenging-Mediated Suppression of PKD-NFkappaB-IL-8 Signaling Pathway by Chlorogenic and Caffeic Acids in Human Intestinal Cells.	Caffeic Acids	137-150	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
28230729-1	2017	Chlorogenic acid (CHA) and caffeic acid (CA) are phenolic compounds found in coffee, which inhibit oxidative stress-induced interleukin (IL)-8 production in intestinal epithelial cells, thereby suppressing serious cellular injury and inflammatory intestinal diseases.	Chlorogenic Acid	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	124-142
28230729-1	2017	Chlorogenic acid (CHA) and caffeic acid (CA) are phenolic compounds found in coffee, which inhibit oxidative stress-induced interleukin (IL)-8 production in intestinal epithelial cells, thereby suppressing serious cellular injury and inflammatory intestinal diseases.	Chlorogenic Acid	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	124-142
28230729-2	2017	Therefore, we investigated the anti-inflammatory mechanism of CHA and CA, both of which inhibited hydrogen peroxide (H2O2)-induced IL-8 transcriptional activity.	Chlorogenic Acid	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
28230729-2	2017	Therefore, we investigated the anti-inflammatory mechanism of CHA and CA, both of which inhibited hydrogen peroxide (H2O2)-induced IL-8 transcriptional activity.	Hydrogen Peroxide	98-115	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
28230729-2	2017	Therefore, we investigated the anti-inflammatory mechanism of CHA and CA, both of which inhibited hydrogen peroxide (H2O2)-induced IL-8 transcriptional activity.	Hydrogen Peroxide	117-121	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
28230729-6	2017	Therefore, we conclude that the presence of catechol groups in CHA and CA allows scavenging of intracellular ROS, thereby inhibiting H2O2-induced IL-8 production via suppression of PKD-NF-kappaB signaling in human intestinal epithelial cells.	catechol	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
28230729-6	2017	Therefore, we conclude that the presence of catechol groups in CHA and CA allows scavenging of intracellular ROS, thereby inhibiting H2O2-induced IL-8 production via suppression of PKD-NF-kappaB signaling in human intestinal epithelial cells.	Reactive Oxygen Species	109-112	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
28230729-6	2017	Therefore, we conclude that the presence of catechol groups in CHA and CA allows scavenging of intracellular ROS, thereby inhibiting H2O2-induced IL-8 production via suppression of PKD-NF-kappaB signaling in human intestinal epithelial cells.	Hydrogen Peroxide	133-137	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
28178959-14	2017	CONCLUSION: IL-8 is a target to explore further as a predictor of 28 days mortality, in patients with AHRF treated with NPPV.	nppv	120-124	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
27940299-4	2017	Moreover, like E2 and G1, Cd leads to a rapid activation of ERK/AKT, and then nuclear translocation of NF-kappaB, increased expression of cyclin A and D1, and secretion of IL-8, all of which are significantly attenuated by GPER blockage or knock-down in both WRO and FRO cells.	Cadmium	26-28	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
28108387-4	2017	Pretreatment with MAO-B selective inhibitor selegiline reversed the CSM-induced changes in MAO-B activity, ROS levels and IL-8 release in a dose-dependent manner.	Selegiline	44-54	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
27998979-11	2017	Dexamethasone induces the recruitment of ACTN4 and GR to putative GREs in dexamethasone-transactivated promoters, SERPINE1, ANGPLT4, CCL20, and SAA1 as well as the NF-kappaB (p65) binding sites on GR-transrepressed promoters such as IL-1beta, IL-6, and IL-8 Taken together, our data establish ACTN4 as a transcriptional co-regulator that modulates both dexamethasone-transactivated and -transrepressed genes in podocytes.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	253-257
27998979-11	2017	Dexamethasone induces the recruitment of ACTN4 and GR to putative GREs in dexamethasone-transactivated promoters, SERPINE1, ANGPLT4, CCL20, and SAA1 as well as the NF-kappaB (p65) binding sites on GR-transrepressed promoters such as IL-1beta, IL-6, and IL-8 Taken together, our data establish ACTN4 as a transcriptional co-regulator that modulates both dexamethasone-transactivated and -transrepressed genes in podocytes.	Dexamethasone	74-87	C-X-C motif chemokine ligand 8	Homo sapiens	253-257
27618139-0	2017	Significant Decrease in Plasma Levels of D-Dimer, Interleukin-8, and Interleukin-12 After a 12-Month Treatment with Rosuvastatin in HIV-Infected Patients Under Antiretroviral Therapy.	Rosuvastatin Calcium	116-128	C-X-C motif chemokine ligand 8	Homo sapiens	50-63
28058843-0	2017	Formation of a K-In-Se Surface Species by NaF/KF Postdeposition Treatment of Cu(In,Ga)Se2 Thin-Film Solar Cell Absorbers.	Selenium	20-22	C-X-C motif chemokine ligand 8	Homo sapiens	42-45
30090494-5	2017	Exposure to 50 or 200 muM paraquat for 24 h elevated the release of interleukin 8 and gene expression of tumor necrosis factor-alpha.	Paraquat	26-34	C-X-C motif chemokine ligand 8	Homo sapiens	68-81
27618139-10	2017	CONCLUSIONS: Our findings show that a 12-month treatment with rosuvastatin associated with an effective cART can significantly decrease the plasma levels of D-dimer, IL-8, and IL-12, and suggest a potential role for this statin to reduce activated coagulation and systemic inflammation among HIV-infected persons.	Rosuvastatin Calcium	62-74	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
28058843-0	2017	Formation of a K-In-Se Surface Species by NaF/KF Postdeposition Treatment of Cu(In,Ga)Se2 Thin-Film Solar Cell Absorbers.	Copper	77-79	C-X-C motif chemokine ligand 8	Homo sapiens	42-45
28058843-1	2017	A NaF/KF postdeposition treatment (PDT) has recently been employed to achieve new record efficiencies of Cu(In,Ga)Se2 (CIGSe) thin film solar cells.	Copper	105-107	C-X-C motif chemokine ligand 8	Homo sapiens	2-5
28006108-5	2017	The primary objective was to measure the effects of digitoxin on IL-8 and neutrophil counts in induced sputum.	Digitoxin	52-61	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
28058843-5	2017	The NaF/KF-PDT, however, leads to the formation of bilayer structure in which a K-In-Se species covers the CIGSe compound that in composition is identical to the chalcopyrite structure of the alkali-free and NaF-PDT absorber.	lysylphenylalanine	8-10	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
28058843-5	2017	The NaF/KF-PDT, however, leads to the formation of bilayer structure in which a K-In-Se species covers the CIGSe compound that in composition is identical to the chalcopyrite structure of the alkali-free and NaF-PDT absorber.	lysylphenylalanine	8-10	C-X-C motif chemokine ligand 8	Homo sapiens	208-211
28058843-5	2017	The NaF/KF-PDT, however, leads to the formation of bilayer structure in which a K-In-Se species covers the CIGSe compound that in composition is identical to the chalcopyrite structure of the alkali-free and NaF-PDT absorber.	k-in-se	80-87	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
28058843-5	2017	The NaF/KF-PDT, however, leads to the formation of bilayer structure in which a K-In-Se species covers the CIGSe compound that in composition is identical to the chalcopyrite structure of the alkali-free and NaF-PDT absorber.	chalcopyrite	162-174	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
27796814-14	2017	Interleukin-8 may be an important mediator for hepatic fibrosis in nonalcoholic fatty liver disease patients with low vitamin D status.	Vitamin D	118-127	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
26965496-8	2017	Global proteome analysis showed that the NRF2-mediated stress response and the CXCL8 (IL-8) pathway were induced by ketoconazole treatment under co-culture conditions.	Ketoconazole	116-128	C-X-C motif chemokine ligand 8	Homo sapiens	79-84
26965496-8	2017	Global proteome analysis showed that the NRF2-mediated stress response and the CXCL8 (IL-8) pathway were induced by ketoconazole treatment under co-culture conditions.	Ketoconazole	116-128	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
26965496-9	2017	The upregulation and ketoconazole-induced secretion of several pro-inflammatory cytokines, including CXCL8, TNF-alpha and CCL3, was observed in the co-culture system only, but not in single cell cultures.	Ketoconazole	21-33	C-X-C motif chemokine ligand 8	Homo sapiens	101-106
27879488-0	2017	18F-NaF PET Demonstrating Unusual Focal Tracer Activity in the Brain.	Fluorine-18	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
27863334-7	2017	Conversely, in phorbol 12-myristate 13-acetate and ionomycin (PMA/Io) stimulated Caco-2 cells, lactobacilli from the omnivorous group and all bifidobacteria significantly down-regulated IL-8.	Tetradecanoylphorbol Acetate	15-46	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
27863334-7	2017	Conversely, in phorbol 12-myristate 13-acetate and ionomycin (PMA/Io) stimulated Caco-2 cells, lactobacilli from the omnivorous group and all bifidobacteria significantly down-regulated IL-8.	Ionomycin	51-60	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
27863334-7	2017	Conversely, in phorbol 12-myristate 13-acetate and ionomycin (PMA/Io) stimulated Caco-2 cells, lactobacilli from the omnivorous group and all bifidobacteria significantly down-regulated IL-8.	Tetradecanoylphorbol Acetate	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
27988459-4	2017	One of these derivatives, (Z)-2-((5-(hydroxymethyl) furan-2-yl) methylene) benzofuran-3(2H)-one (aurone 1), was found to inhibit LPS-induced secretion of the pro-inflammatory cytokines, tumor-necrosis factor alpha (TNFalpha), interleukin 1beta (IL-1beta), and IL-8 by THP-1 cells.	(z)-2-((5-(hydroxymethyl) furan-2-yl) methylene) benzofuran-3(2h)-one	26-95	C-X-C motif chemokine ligand 8	Homo sapiens	260-264
28013186-7	2017	RESULTS: Treatment with PT or PO inhibited the secretion of interleukin (IL)-8 and tumor necrosis factor (TNF) in ethanol- or LPS-stimulated KATO III cells.	Ethanol	114-121	C-X-C motif chemokine ligand 8	Homo sapiens	60-78
27966575-8	2017	The combined group of vitamin D2 and D3 treated patients decreased plasma IL-8 (P&lt;0.05).	Ergocalciferols	22-32	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
27966575-8	2017	The combined group of vitamin D2 and D3 treated patients decreased plasma IL-8 (P&lt;0.05).	Cholecalciferol	37-39	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
27739345-0	2017	Rosuvastatin Inhibits Interleukin (IL)-8 and IL-6 Production in Human Coronary Artery Endothelial Cells Stimulated With Aggregatibacter actinomycetemcomitans Serotype b.	Rosuvastatin Calcium	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	22-40
27186953-5	2017	Unexpectedly, NaW further induced IL-6, IL-8, and MCP-1 secretion in both N- and D-RPTEC, together with lower levels of IL-1 RA, IL-4, IL-10, and GM-CSF, suggesting that it may contribute to the extent of renal damage/repair during DKD.	naw	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
28000839-9	2017	IL-6 and IL-8 expression was inhibited completely by treatment with the NF-kappaB inhibitor, BAY11-7082.	3-(4-methylphenylsulfonyl)-2-propenenitrile	93-103	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
28035387-10	2017	Additionally, levels of IL-6 and IL-8 were significantly decreased by prednisone, ibuprofen and betamethasone.	Prednisone	70-80	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
28067893-0	2017	Vemurafenib and trametinib reduce expression of CTGF and IL-8 in V600EBRAF melanoma cells.	Vemurafenib	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
28067893-0	2017	Vemurafenib and trametinib reduce expression of CTGF and IL-8 in V600EBRAF melanoma cells.	trametinib	16-26	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
28067893-11	2017	Interestingly, expression of IL-8 and CTGF was significantly reduced by treatment with vemurafenib and trametinib.	Vemurafenib	87-98	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
28067893-11	2017	Interestingly, expression of IL-8 and CTGF was significantly reduced by treatment with vemurafenib and trametinib.	trametinib	103-113	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
28064076-7	2017	Drospirenone significantly decreased IL-6, IL-8, VEGF and NGF mRNA expression by ESC.	drospirenone	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
28064076-8	2017	Drospirenone (10-5M) significantly decreased IL-6 secretion and 10-7M drospirenone decreased IL-8 and VEGF secretion.	drospirenone	70-82	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
28151872-2	2017	The aim of this study was to elucidate whether serum levels of IL-6 and IL-8 at diagnosis could predict the tumor progression pattern of PDAC, especially in extensive hepatic metastasis.According to the tumor burden of hepatic metastasis at the last follow-up, tumor progression pattern was defined as follows: no or limited (unilobar involvement and 5 or less in the within liver, limited group) and extensive hepatic metastasis (bilobar or more than 5, progressed group).	pdac	137-141	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
28035387-12	2017	In combination with IL-6 or IL-8, prednisone, ibuprofen and betamethasone significantly reduced the levels of collagen I, MMP-1 and MMP-13, and inactivated NF-kappaB and STAT3 pathways.	Betamethasone	60-73	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
28035387-13	2017	In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.	Prednisone	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
28035387-10	2017	Additionally, levels of IL-6 and IL-8 were significantly decreased by prednisone, ibuprofen and betamethasone.	Ibuprofen	82-91	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
28035387-13	2017	In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.	Ibuprofen	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
28035387-10	2017	Additionally, levels of IL-6 and IL-8 were significantly decreased by prednisone, ibuprofen and betamethasone.	Betamethasone	96-109	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
28035387-13	2017	In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.	Betamethasone	41-54	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
27546737-2	2017	METHODS AND RESULTS: Irisolidone and kakkalide inhibited IL-8 secretion and NF-kappaB activation in lipopolysaccharide-stimulated KATO III cells.	irisolidone	21-32	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
28035387-12	2017	In combination with IL-6 or IL-8, prednisone, ibuprofen and betamethasone significantly reduced the levels of collagen I, MMP-1 and MMP-13, and inactivated NF-kappaB and STAT3 pathways.	Ibuprofen	46-55	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
27546737-2	2017	METHODS AND RESULTS: Irisolidone and kakkalide inhibited IL-8 secretion and NF-kappaB activation in lipopolysaccharide-stimulated KATO III cells.	kakkalide	37-46	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
27574898-7	2017	In the SW1353 cell line model, zingerone efficiently suppressed the expression of TNF-alpha, interleukin-6, and interleukin-8 mRNA levels and tended to reduce the levels of both p38 and c-Jun N-terminal kinase phosphorylation.	zingerone	31-40	C-X-C motif chemokine ligand 8	Homo sapiens	112-125
27561918-3	2017	The transported polyphenols were able to downregulate the secretion of pro-inflammatory markers, i.e. IL-8, monocyte chemoattractant protein 1, vascular endothelial growth factor, and intercellular adhesion molecule 1, under normal and tumor necrosis factor alpha induced inflammatory conditions.	Polyphenols	16-27	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
28007550-9	2017	Transient changes in urothelial ATP and PGE2 release were observed, with significant increase in release of interleukin-6, interleukin-8 and interleukin-1beta from urothelial cells treated with gemcitabine.	gemcitabine	194-205	C-X-C motif chemokine ligand 8	Homo sapiens	123-136
27736317-6	2017	OACs in coculture with AMs expressed significantly higher levels of MMP-1, MMP-3, MMP-9, MMP-13, IL-1beta, TNF-alpha, IL-6, IL-8, and IFN-gamma compared to OACs in mono-culture, indicating that proinflammatory macrophages may intensify the abnormal matrix degradation and cytokine secretion already associated with OACs.	oacs	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
27746371-9	2017	Moreover, IL-8 production induced by PHMB was completely suppressed by a NF-kappaB inhibitor, but not by a ROS scavenger.	polihexanide	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
27596523-6	2017	We also analyzed the effects of CS exposure on the inflammatory response, and observed a significant increase in secretion of IL-8, GRO-alpha, IL-1beta, and GM-CSF.	Cesium	32-34	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
28118826-8	2017	Concentrations of NAC &gt;=300 muM inhibited the inflammatory response (release of IL-1beta, IL-8, and TNF-alpha) of human airways induced by the overnight stimulation with LPS, whereas lower concentrations of NAC (&gt;=1 muM) were sufficient to reduce the release of IL-6 elicited by LPS.	Acetylcysteine	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
27913418-6	2017	Subsequently, we demonstrated that DG-EPS displays immunostimulating properties by enhancing the gene expression of the proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), and particularly that of the chemokines IL-8 and CCL20, in the human monocytic cell line THP-1.	dg-eps	35-41	C-X-C motif chemokine ligand 8	Homo sapiens	252-256
28004929-1	2017	23Na MAS NMR spectra of sodium-oxygen (Na-O2) cathodes reveals a combination of degradation species: newly observed sodium fluoride (NaF) and the expected sodium carbonate (Na2CO3), as well as the desired reaction product sodium peroxide (Na2O2).	sodium-oxygen (na-o2) cathodes	24-54	C-X-C motif chemokine ligand 8	Homo sapiens	133-136
28004929-1	2017	23Na MAS NMR spectra of sodium-oxygen (Na-O2) cathodes reveals a combination of degradation species: newly observed sodium fluoride (NaF) and the expected sodium carbonate (Na2CO3), as well as the desired reaction product sodium peroxide (Na2O2).	Sodium Fluoride	116-131	C-X-C motif chemokine ligand 8	Homo sapiens	133-136
28004929-3	2017	The reactivity of solid NaO2 is probed further, and NaF is found to be formed through a reaction between the electrochemically generated NaO2 and the electrode binder, polyvinylidene fluoride (PVDF).	NaO2	24-28	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
28107509-6	2017	RESULTS: Exposing the 3D models to Pd nanoparticles induced increased secretion of IL-8, yet the chronic bronchitis-like model released significantly more IL-8 than the normal model.	Palladium	35-37	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
28107509-6	2017	RESULTS: Exposing the 3D models to Pd nanoparticles induced increased secretion of IL-8, yet the chronic bronchitis-like model released significantly more IL-8 than the normal model.	Palladium	35-37	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
28149283-7	2016	In the alcohol group, CXCL8 concentrations were increased in patients with liver and pancreas diseases and there was a significant correlation to aspartate transaminase (r = +0.456, p &lt; 0.001) and gamma-glutamyltransferase (r = +0.647, p &lt; 0.001).	Alcohols	7-14	C-X-C motif chemokine ligand 8	Homo sapiens	22-27
28004929-3	2017	The reactivity of solid NaO2 is probed further, and NaF is found to be formed through a reaction between the electrochemically generated NaO2 and the electrode binder, polyvinylidene fluoride (PVDF).	NaO2	137-141	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
28456799-10	2017	In addition, allicin attenuated the LPS-induced inflammatory responses, including endothelial cell adhesion and TNF-alpha and IL-8 production.	allicin	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
28004929-3	2017	The reactivity of solid NaO2 is probed further, and NaF is found to be formed through a reaction between the electrochemically generated NaO2 and the electrode binder, polyvinylidene fluoride (PVDF).	polyvinylidene fluoride	168-191	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
28004929-3	2017	The reactivity of solid NaO2 is probed further, and NaF is found to be formed through a reaction between the electrochemically generated NaO2 and the electrode binder, polyvinylidene fluoride (PVDF).	polyvinylidene fluoride	193-197	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
27988394-5	2017	UFP-induced IL-8 could be reduced by SB203580, indicating a role of p38MAPK activation in IL-8 production.	SB 203580	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
27988394-5	2017	UFP-induced IL-8 could be reduced by SB203580, indicating a role of p38MAPK activation in IL-8 production.	SB 203580	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
28849490-7	2017	Treatment with Tau-Ribose significantly modulated the production of IL-8 and IL-6.	tau-ribose	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
28977796-9	2017	Under normal flow, SnF/NaF showed higher efficacy, with a significant difference compared to NaF/Sn/Ch, NaF, and placebo (p &lt; 0.05).	Tin	19-21	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
28977796-11	2017	Comparing salivary conditions, there were significant differences for SnF/NaF for %SMH after the in situ phase (%SMHtotal)), %RHL and for all toothpastes in case of %RER.	N-(2-Ethoxyethyl)-N-{(2s)-2-Hydroxy-3-[(2r)-6-Hydroxy-4-Oxo-3,4-Dihydro-1'h-Spiro[chromene-2,3'-Piperidin]-1'-Yl]propyl}-2,6-Dimethylbenzenesulfonamide	83-86	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
28214842-10	2017	The in vitro AGEs generation was also able to be enhanced by the exposure of HaCaT cells to MGO, which reduced dose-dependently cellular viability, damaged mitochondrial function, triggered secretion of interleukin (IL)-6 and IL-8, activated NF-kappaB and upregulated MMP-9 expression.	Pyruvaldehyde	92-95	C-X-C motif chemokine ligand 8	Homo sapiens	226-230
28002795-0	2017	Sodium fluoride (NaF) causes toxic effects on splenic development in mice.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
28002795-1	2017	At present, very limited studies focus on the toxic effect of sodium fluoride (NaF) on splenic development of human and animals in vivo.	Sodium Fluoride	62-77	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
27832944-9	2017	The results indicated that CAPE inhibits LPS-induced IL-6, IL-8, iNOS, and COX-2 production in a dose-dependent manner.	caffeic acid phenethyl ester	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
29250545-10	2017	Simvastatin significantly reduced the levels of cTnT, CK-MB, TNF-alpha, IL-6, and IL-8 (P &lt; 0.05), reduced the expression of LC3-II/LC3-I and Beclin 1, and increased the expression of phosphorylation of AMPK.	Simvastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
28027722-4	2017	Celastrol significantly inhibited poly(I:C)-induced expression of adhesion molecules, such as ICAM-1/VCAM-1, and chemokines, such as CCL2, CXCL8, and CXCL10, in CRT-MG human astroglioma cells.	celastrol	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	139-144
27846001-5	2017	Although the skeletal uptake of F-NaF was without signs of focal metastasis, the F-NaF PET/CT scanning surprisingly revealed diffuse high accumulation of F-NaF in the lung parenchyma, possibly because of calcium deposition in the lung parenchyma associated to amyloidosis seen in patients with myelomatosis.	Calcium	204-211	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
28680337-5	2017	Glutathione treatment decreased the serum levels of asparaginic acid transaminase, alanine aminotransferase, total bilirubin, total bile acids, haluronic acid, collagen IV, laminin, transforming growth factor-beta1, tumour necrosis factor-alpha, interleukin-6, and interleukin-8, compared with the control group.	Glutathione	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	265-278
27883241-7	2017	RESULTS: Untreated and IL-8-treated PBNs from the SA group produced higher autophagy and NET levels compared with those from the NSA group (P &lt; 0.01).	pbns	36-40	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
27883241-7	2017	RESULTS: Untreated and IL-8-treated PBNs from the SA group produced higher autophagy and NET levels compared with those from the NSA group (P &lt; 0.01).	sa	50-52	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
27883241-8	2017	IL-8 increased autophagy and NET levels in PBNs from the SA group, but not from the NSA group.	pbns	43-47	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
27883241-8	2017	IL-8 increased autophagy and NET levels in PBNs from the SA group, but not from the NSA group.	sa	57-59	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
28124586-8	2017	RESULTS: High glucose (30.5 mM) increased mRNA expression of interleukin (IL)-6 and secretion of both IL-6 and IL-8 by astrocytes.	Glucose	14-21	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
29721026-8	2017	Preincubation of ozone at 50 mug/ml decreases IL-8, IL-6, and IL-1beta production by 50, 56, and 70%, respectively, compared to untreated cells.	Ozone	17-22	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
27573638-11	2017	Follow-up 18F-NaF PET/CT showed persistence of 81.5 % of the baseline 18F-NaF positive MM lesions after treatment, despite the fact that 64.7 % of them had turned to 18F-FDG negative.	Fluorine-18	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	14-17
27573638-11	2017	Follow-up 18F-NaF PET/CT showed persistence of 81.5 % of the baseline 18F-NaF positive MM lesions after treatment, despite the fact that 64.7 % of them had turned to 18F-FDG negative.	Fluorine-18	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
29227717-6	2017	Corticosteroid sensitivity was determined as the dexamethasone concentration causing 40% inhibition of tumor necrosis factor alpha-induced CXCL8 production (Dex-IC40) in the presence or absence of quercetin.	Dexamethasone	49-62	C-X-C motif chemokine ligand 8	Homo sapiens	139-144
29256349-5	2017	Notably, analysis of the drug-resistant melanoma cell line selected after prolonged exposure to chemotherapeutic drug dacarbazine revealed higher levels of CXCL8 and CXCR2 compared with parent cells as a signature of drug resistance.	Dacarbazine	118-129	C-X-C motif chemokine ligand 8	Homo sapiens	156-161
27865894-7	2017	CYLD induction mediated, at least in part, the TZD-mediated downregulation of tumor necrosis factor alpha (TNFalpha)-induced interleukin 8 (IL-8).	tzd	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	125-138
27821648-6	2017	The MAPK and NF-kappaB pathways are involved in both the PKC-mediated and bufalin-promoted PKC regulation of COX-2/IL-8 production.	bufalin	74-81	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
27821648-10	2017	Bufalin significantly enhances breast cancer xenograft growth, which is accompanied by an elevation in COX-2/IL-8 expression.	bufalin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
27821648-5	2017	Using MB-231 breast cancer cells, bufalin augments PKC induction of COX-2/IL-8 at both the protein and mRNA levels, and the production of prostaglandin E2 (PGE2) and IL-8.	bufalin	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
27821648-5	2017	Using MB-231 breast cancer cells, bufalin augments PKC induction of COX-2/IL-8 at both the protein and mRNA levels, and the production of prostaglandin E2 (PGE2) and IL-8.	bufalin	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
27865894-7	2017	CYLD induction mediated, at least in part, the TZD-mediated downregulation of tumor necrosis factor alpha (TNFalpha)-induced interleukin 8 (IL-8).	tzd	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
28751819-7	2017	Tryptase, PAR2 agonists, histamine, and TNF-alpha all enhanced interleukin 8 production by RPE cells, while only tryptase enhanced VEGF production.	Histamine	25-34	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
29683134-5	2017	DHA administration resulted in approximately a doubling of plasma and red cell phospholipid and adipose tissue DHA content but no change in systemic markers of inflammation, such as circulating C-reactive protein (CRP) or interleukins (IL) 6, 8 and 10 (IL-6, IL-8, IL-10).	Docosahexaenoic Acids	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	259-263
29225318-8	2017	Protein microarray analysis showed caffeine suppresses the secretion of inflammatory cytokines, interleukin-8 and plasminogen activator inhibitor-1 from Caco-2 cells.	Caffeine	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	96-147
27329245-7	2017	In a study of SASP markers, the expressions of IL6 and IL8 were also more upregulated in human non-pathological prostatic glands after ADT than in untreated specimens.	adt	135-138	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
27329245-8	2017	IL6, IL8, and MMP2 were expressed more strongly in human prostate cancer specimens resected after ADT than in untreated tumors.	adt	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	5-8
28163398-0	2017	kappa-Carrageenan Enhances Lipopolysaccharide-Induced Interleukin-8 Secretion by Stimulating the Bcl10-NF-kappaB Pathway in HT-29 Cells and Aggravates C. freundii-Induced Inflammation in Mice.	Carrageenan	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
28163398-5	2017	We investigated whether the kappa-carrageenan could enhance lipopolysaccharide-induced IL-8 expression by studying its actions on the TLR4-NF-kappaB pathway.	Carrageenan	28-45	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
28163398-8	2017	Our data show that kappa-carrageenan pretreatment promoted LPS-induced IL-8 expression in HT-29 cells.	Carrageenan	19-36	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
27878250-2	2017	This study aimed to examine the effects and mechanisms of action of SN38 (a metabolite of the camptothecin derivative, CPT-11) on IL-8 expression in HCT8 cells, using ELISA, CCK-8 and western blot analysis.	Camptothecin	94-106	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
27878250-4	2017	Of the other agents, evodiamine was found to inhibit both IL-8 secretion and cell proliferation, and jatrorrhizine was found to increase IL-8 secretion without any obvious inhibitory effect on cell proliferation.	evodiamine	21-31	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
27878250-4	2017	Of the other agents, evodiamine was found to inhibit both IL-8 secretion and cell proliferation, and jatrorrhizine was found to increase IL-8 secretion without any obvious inhibitory effect on cell proliferation.	jatrorrhizine	101-114	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
27878250-7	2017	Thus, the potential benefit of the use of a combination of camptothecin-11 with other chemical drugs with inhibitory effects on IL-8 expression, should be paid more attention in treating colon cancer.	Irinotecan	59-74	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
27793704-9	2017	RESULTS: For %KHNalt, the polymers alone did not reduce enamel demineralization when compared to the negative control, but Carbopol associated with NaF significantly improved its protective effect.	carboxypolymethylene	123-131	C-X-C motif chemokine ligand 8	Homo sapiens	148-151
27793704-11	2017	CONCLUSIONS: It is concluded that Carbopol enhanced NaF"s protection against initial erosion.	carboxypolymethylene	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
27903742-11	2017	Our results indicate that the P2Y6/store-operated calcium entry/IL-8 axis is involved in MSU crystal-induced aggregated NET formation, but MRS2578 could have additional effects affecting PMN migration.	Calcium	50-57	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
27541080-9	2017	Pharmacologic inhibition of AT1R through losartan modulated mRNA transcription of IL-6 and IL-8 in HPLF but not in HGF.	Losartan	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
27541080-11	2017	CONCLUSION: These results suggest that AT1R knockdown and AT1R pharmacologic blockade by losartan may differently control balance of inflammatory cytokines, such as IL-6 and IL-8, in primary human periodontal fibroblasts.	Losartan	89-97	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
29089668-1	2017	The angelicin analogue 4,6,4"-trimethylangelicin (TMA) was recently reported as a strong inhibitor of nuclear factor-kappaB (NF-kappaB) activity and of the expression of the interleukin-8 (IL-8) gene in bronchial epithelial cells in which the inflammatory response has been challenged with P. aeruginosa, the most common bacterium found in the airways of patients affected by cystic fibrosis (CF).	angelicin	4-13	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
29089668-1	2017	The angelicin analogue 4,6,4"-trimethylangelicin (TMA) was recently reported as a strong inhibitor of nuclear factor-kappaB (NF-kappaB) activity and of the expression of the interleukin-8 (IL-8) gene in bronchial epithelial cells in which the inflammatory response has been challenged with P. aeruginosa, the most common bacterium found in the airways of patients affected by cystic fibrosis (CF).	4,4',6-trimethylangelicin	23-48	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
29089668-1	2017	The angelicin analogue 4,6,4"-trimethylangelicin (TMA) was recently reported as a strong inhibitor of nuclear factor-kappaB (NF-kappaB) activity and of the expression of the interleukin-8 (IL-8) gene in bronchial epithelial cells in which the inflammatory response has been challenged with P. aeruginosa, the most common bacterium found in the airways of patients affected by cystic fibrosis (CF).	4,4',6-trimethylangelicin	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
28592115-3	2017	Among the inflammation-associated cytokines assayed, high level of chemokines CXCL8/IL-8 (6.82-fold increase) and CXCL10/IP-10 (16.45-fold increase) in TCS than that in paired NCS were evidently identified.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	152-155	C-X-C motif chemokine ligand 8	Homo sapiens	78-83
28592115-3	2017	Among the inflammation-associated cytokines assayed, high level of chemokines CXCL8/IL-8 (6.82-fold increase) and CXCL10/IP-10 (16.45-fold increase) in TCS than that in paired NCS were evidently identified.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	152-155	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
29558759-7	2017	RESULTS: Treatment with antipsychotic drugs plus vitamin B12 led to a decreased expression of IL-8 and TNF-alpha and an increased expression of TGF-beta.	Vitamin B 12	49-60	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
29514151-13	2017	Dopamine significantly increased IL-8 production in human macrophages, an effect that was partially reduced by propranolol.	Dopamine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
27819395-3	2017	Here, we describe the mechanisms through which TCA affects human astrocytes, demonstrating: a late apoptotic process, mediated by caspases 9 and 3 activation, involving the Bcl2-Bak-axis; an early and late p38 MAPK activation; an interference with the IL-8 and MCP-1 secretory response.	Trichloroacetic Acid	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	252-256
29514151-13	2017	Dopamine significantly increased IL-8 production in human macrophages, an effect that was partially reduced by propranolol.	Propranolol	111-122	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
29558759-5	2017	Thus, the main aim of this clinical trial study was to determine the effects of treatment with risperidone and quetiapine, as antipsychotic drugs, with and without vitamin B12 on the psychotic symptoms of AD patients and the expression of IL-6, IL-8, tumor growth factor (TGF)-beta, tumor necrosis factor (TNF)-alpha, and endothelin (ET)-1).	Risperidone	95-106	C-X-C motif chemokine ligand 8	Homo sapiens	245-249
27813716-9	2017	PGF around nonirradiated mini-implants showed higher levels of IL-8.	Prostaglandins F	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
28831459-9	2017	CONCLUSION: The AmF/NaF/SnCl2 solution proved to be effective in reducing dental enamel surface loss and its use twice a day potentiated its anti-erosive effect.	stannous chloride	24-29	C-X-C motif chemokine ligand 8	Homo sapiens	20-23
29147073-0	2017	Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line.	Metformin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	21-26
29147073-5	2017	This study intended to address the role of metformin in regulation of CXCL8 expression and cell proliferation and migration.	Metformin	43-52	C-X-C motif chemokine ligand 8	Homo sapiens	70-75
29147073-6	2017	Our data indicated that metformin suppressed LPS-induced CXCL8 expression in a dose-dependent manner through inhibiting NF-kappaB, but not AP-1 and C/EBP, activities under the conditions we used.	Metformin	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	57-62
28804534-6	2017	In addition, when infected by prominent periodontal pathogens, Porphyromonas gingivalis (ATCC 33277), rapamycin-pretreated groups decreased the expression of inflammatory cytokines (IL-6 and IL-8) compared with the control group.	Sirolimus	102-111	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
28088291-5	2017	Both anteiso- and iso- BCFA reduce IL-8.	anteiso- and iso- bcfa	5-27	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
28088291-0	2017	BCFA suppresses LPS induced IL-8 mRNA expression in human intestinal epithelial cells.	bcfa	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
28088291-6	2017	Anteiso-BCFA more effectively suppressed IL-8 than iso-BCFA in LPS stimulated Caco-2 cells.	anteiso-bcfa	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
28462713-11	2017	Full length PMAP-23 induced IL-8 production in porcine epithelial cells, however, this activity was lost in all truncated peptides.	pmap	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
28088291-6	2017	Anteiso-BCFA more effectively suppressed IL-8 than iso-BCFA in LPS stimulated Caco-2 cells.	bcfa	8-12	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
27411707-7	2016	Interestingly, although very high concentrations (25-50 microM) of Simvastatin resulted in dramatically less IL-6 and IL-8 pro-inflammatory cytokine secretion, 2.5 microM Simvastatin did not reduce the total amount of pro-inflammatory cytokines secreted during mechanical stimulation.	Simvastatin	67-78	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
27989874-9	2016	RESULTS: Ingestion of DT suppressed CD4+ T cell expression of IL-1beta and Il-8 (p&lt;0.05) and up-regulated the expression of IL-10 and the Treg/IL-17 ratio (p&lt;0.05) which was not shown in PL.	Thymidine	22-24	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
28039491-0	2016	Sodium fluoride (NaF) induces the splenic apoptosis via endoplasmic reticulum (ER) stress pathway in vivo and in vitro.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
28039491-2	2016	Therefore, the aim of this study was to define sodium fluoride (NaF)-induced apoptosis mediated by ER stress in the spleen of mice in vivo and in vitro.	Sodium Fluoride	47-62	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
27935985-0	2016	miR-125b Enhances IL-8 Production in Early-Onset Severe Preeclampsia by Targeting Sphingosine-1-Phosphate Lyase 1.	mir-125b	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
27935985-5	2016	We also found that miR-125b enhanced IL-8 production by directly targeting sphingosine-1-phosphate lyase 1 (SGPL1), and this effect could be reversed by SGPL1 overexpression.	mir-125b	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
27935985-7	2016	Our data demonstrated a critical role of miR-125b in IL-8 production and the development of PE.	mir-125b	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
27789120-8	2016	Curcumin was found to exert diverse immunomodulatory effects, including suppression of IL-4, IL-8, and tumor necrosis factor alpha and increased production of IL-10 and soluble intercellular adhesion molecule.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
27489081-0	2016	Activation of liver X receptor attenuates lysophosphatidylcholine-induced IL-8 expression in endothelial cells via the NF-kappaB pathway and SUMOylation.	Lysophosphatidylcholines	42-65	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
27810785-0	2016	Gallic acid reduces cell growth by induction of apoptosis and reduction of IL-8 in HepG2 cells.	Gallic Acid	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
27567939-5	2016	RESULTS: The glucose median value was 4.72mmol/L in SST tubes, 4.67mmol/L in lithium-heparin and 4.44mmol/L in NaF-KOx tubes.	Glucose	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	111-114
26303504-5	2016	The water-soluble and insoluble fractions of PM2.5 suspension were both shown to induce IL-8 expression.	Water	4-9	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
26303504-8	2016	Employment of the transition metal chelators including TPEN (N,N,N",N"-tetrakis (2-pyridylmethyl) ethylenediamine) or DFO (desferrioxamine) inhibited IL-8 expression induced by PM2.5 by over 20% in BEAS-2B cells, but had minimal effect in THP-1 cells.	Metals	29-34	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
26303504-8	2016	Employment of the transition metal chelators including TPEN (N,N,N",N"-tetrakis (2-pyridylmethyl) ethylenediamine) or DFO (desferrioxamine) inhibited IL-8 expression induced by PM2.5 by over 20% in BEAS-2B cells, but had minimal effect in THP-1 cells.	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	55-59	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
26303504-8	2016	Employment of the transition metal chelators including TPEN (N,N,N",N"-tetrakis (2-pyridylmethyl) ethylenediamine) or DFO (desferrioxamine) inhibited IL-8 expression induced by PM2.5 by over 20% in BEAS-2B cells, but had minimal effect in THP-1 cells.	Deferoxamine	118-121	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
26303504-8	2016	Employment of the transition metal chelators including TPEN (N,N,N",N"-tetrakis (2-pyridylmethyl) ethylenediamine) or DFO (desferrioxamine) inhibited IL-8 expression induced by PM2.5 by over 20% in BEAS-2B cells, but had minimal effect in THP-1 cells.	Deferoxamine	123-138	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
27553225-4	2016	Palmitate inhibited IGFBP-3 secretion by THP-1 macrophages and enhanced IL-8 expression.	Palmitates	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
27553225-5	2016	Exposure of palmitate-treated THP-1 macrophages to IGFBP-3-deficient conditioned medium led to a 20-fold increase in palmitate-induced IL-8 expression by hepatocytes.	Palmitates	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
27553225-5	2016	Exposure of palmitate-treated THP-1 macrophages to IGFBP-3-deficient conditioned medium led to a 20-fold increase in palmitate-induced IL-8 expression by hepatocytes.	Palmitates	117-126	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
27553225-6	2016	Conversely, overexpression of IGFBP-3 suppressed JNK and NF-kappaB activation and blocked palmitate-induced IL-8 expression in hepatocytes.	Palmitates	90-99	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
27553225-7	2016	Silencing IGFBP-3 in Huh7 cells enhanced JNK and NF-kappaB activity and increased palmitate-induced IL-8 secretion.	Palmitates	82-91	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
27553225-9	2016	Under lipotoxic conditions, palmitate inhibits hepatic macrophage secretion of IGFBP-3, thereby releasing the brake and enhancing palmitate-induced IL-8 synthesis and secretion.-Min, H.-K., Maruyama, H., Jang, B. K., Shimada, M., Mirshahi, F., Ren, S., Oh, Y., Puri, P., Sanyal, A. J. Suppression of IGF binding protein-3 by palmitate promotes hepatic inflammatory responses.	Palmitates	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
27553225-9	2016	Under lipotoxic conditions, palmitate inhibits hepatic macrophage secretion of IGFBP-3, thereby releasing the brake and enhancing palmitate-induced IL-8 synthesis and secretion.-Min, H.-K., Maruyama, H., Jang, B. K., Shimada, M., Mirshahi, F., Ren, S., Oh, Y., Puri, P., Sanyal, A. J. Suppression of IGF binding protein-3 by palmitate promotes hepatic inflammatory responses.	Palmitates	130-139	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
27553225-9	2016	Under lipotoxic conditions, palmitate inhibits hepatic macrophage secretion of IGFBP-3, thereby releasing the brake and enhancing palmitate-induced IL-8 synthesis and secretion.-Min, H.-K., Maruyama, H., Jang, B. K., Shimada, M., Mirshahi, F., Ren, S., Oh, Y., Puri, P., Sanyal, A. J. Suppression of IGF binding protein-3 by palmitate promotes hepatic inflammatory responses.	Palmitates	130-139	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
27680872-9	2016	Furthermore, the expression of IL-6 and IL-8 increased in LPA-stimulated human primary granulosa cells (P &lt; .01).	lysophosphatidic acid	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
27680872-10	2016	Co-stimulation with rPEDF decreased the expression of LPA-induced IL-6 and IL-8 mRNA and protein by 4- and 2- to 5-fold, respectively.	lysophosphatidic acid	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
28164553-2	2016	The emergence of DTC may be affected by various predisposing genetic alterations and environmental factors The aim of this study was to investigate the role of VEGF C936T and IL-8 A251T gene polymorphisms in the pathogenesis and metastasis of differentiated thyroid cancer.	dtc	17-20	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
28164553-11	2016	The frequency of IL-8 TT was higher in the DTC group with lymph gland metastasis (TT 92%) than in the group without lymph gland metastasis (TT 45.9%) (p &lt; 0.05).	dtc	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
28164553-12	2016	CONCLUSIONS: We consider that the VEGF 936 TT genotype may play a protective role in the development of DTC and that the IL-8 A-251 TT genotype may contribute to the DTC lymph node metastasis.	dtc	166-169	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
27444747-13	2016	Conversely, sex-hormone binding globulin, abdominal visceral fat, interleukin-8, adiponectin were stronger correlates of triglycerides; abdominal visceral fat, and testosterone of high-density lipoprotein cholesterol; and age of both non high-density lipoprotein and low-density lipoprotein in postmenopausal than premenopausal women.	Triglycerides	121-134	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
28391662-2	2016	This study aimed to determine whether a dentifrice containing 5% CSPS and fluoride as sodium fluoride (NaF; "Test dentifrice") was non-inferior to a dentifrice containing 5% CSPS and fluoride as sodium monofluorophosphate (SMFP; "Comparator dentifrice") in reducing DH after eight weeks" twice-daily brushing.	Fluorides	74-82	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
28391662-2	2016	This study aimed to determine whether a dentifrice containing 5% CSPS and fluoride as sodium fluoride (NaF; "Test dentifrice") was non-inferior to a dentifrice containing 5% CSPS and fluoride as sodium monofluorophosphate (SMFP; "Comparator dentifrice") in reducing DH after eight weeks" twice-daily brushing.	Sodium Fluoride	86-101	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
27489081-4	2016	The LXR agonist significantly inhibited lysophosphatidylcholine (LPC)-induced IL-8 production in a dose-dependent manner without appreciable cytotoxicity.	Lysophosphatidylcholines	40-63	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
27489081-4	2016	The LXR agonist significantly inhibited lysophosphatidylcholine (LPC)-induced IL-8 production in a dose-dependent manner without appreciable cytotoxicity.	Lysophosphatidylcholines	65-68	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
27445292-17	2016	18F-NaF PET demonstrates repeatability levels useful for clinically quantifying the response of bone lesions to therapy.	Fluorine-18	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
28066685-6	2016	Linoleic acid also significantly increased IL-6 by 2.9-fold and IL-8 by 5.7-fold.	Linoleic Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
28066685-8	2016	Linoleic acid increased IL-8 concentrations by 56% in human RMEC conditioned medium.	Linoleic Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
27779898-7	2016	The active form of VD is 1,25(OH)2D3 that produces biological effects via the nuclear hormone receptor named VD receptor (VDR), which may interfere with the immune cells and macrophages leading to the suppression of the inflammatory process by decreasing the release of TNF-alpha, IL-1, IL-6, and IL-8, IL-12, and IL-23.	Calcitriol	25-36	C-X-C motif chemokine ligand 8	Homo sapiens	297-301
27634981-1	2016	We describe the role of 18F-sodium fluoride (18F-NaF) PET/CT bone scanning in the staging of breast and prostate cancer.	18f-sodium fluoride	24-43	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
28039406-13	2016	Polyphenol supplementation may attenuate the IL-8 response, however, did not affect granulocyte percentage and adhesion molecule expression in peripheral blood following resistance exercise.	Polyphenols	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
27906095-0	2016	Resveratrol and acetyl-resveratrol modulate activity of VEGF and IL-8 in ovarian cancer cell aggregates via attenuation of the NF-kappaB protein.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
27906095-0	2016	Resveratrol and acetyl-resveratrol modulate activity of VEGF and IL-8 in ovarian cancer cell aggregates via attenuation of the NF-kappaB protein.	acetyl-resveratrol	16-34	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
27416953-5	2016	Then, cells were kept in contact with inflammatory cytokines (TNF-alpha, IL-1beta, IL-6, and IL-8) in serum-free DMEM for 24 hours.	dmem	113-117	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
27090657-3	2016	Monomer 2,7-(2-hydroxy-3-methacryloyloxypropoxy)naphthalene (2,7-NAF.DM) with luminophoric properties was immobilized on silica and carbon nanotubes in two ways: mechanical mixing with previously obtained polymer and by in situ oligomerization with chemisorption after carrier"s modification with vinyl groups.	HNPM	8-59	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
27090657-3	2016	Monomer 2,7-(2-hydroxy-3-methacryloyloxypropoxy)naphthalene (2,7-NAF.DM) with luminophoric properties was immobilized on silica and carbon nanotubes in two ways: mechanical mixing with previously obtained polymer and by in situ oligomerization with chemisorption after carrier"s modification with vinyl groups.	dm	69-71	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
27090657-3	2016	Monomer 2,7-(2-hydroxy-3-methacryloyloxypropoxy)naphthalene (2,7-NAF.DM) with luminophoric properties was immobilized on silica and carbon nanotubes in two ways: mechanical mixing with previously obtained polymer and by in situ oligomerization with chemisorption after carrier"s modification with vinyl groups.	Silicon Dioxide	121-127	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
27782292-5	2016	DMA significantly attenuated the secretion of TNFalpha, IL-6, IL-10, and granulocyte macrophage colony stimulating factor (GM-CSF) from LPS-stimulated RAW 264.7 cells, IL-6 secretion from TNFalpha-stimulated JEG-3 cells and TNFalpha, IL-6, IL-10, GM-CSF and Interleukin-8 (IL-8) from LPS-stimulated human placental explants.	dimethylacetamide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	258-271
27782292-5	2016	DMA significantly attenuated the secretion of TNFalpha, IL-6, IL-10, and granulocyte macrophage colony stimulating factor (GM-CSF) from LPS-stimulated RAW 264.7 cells, IL-6 secretion from TNFalpha-stimulated JEG-3 cells and TNFalpha, IL-6, IL-10, GM-CSF and Interleukin-8 (IL-8) from LPS-stimulated human placental explants.	dimethylacetamide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	273-277
27889107-6	2016	However, supplementing adipocytes with an equal combination of malvidin plus peonidin followed by LPS treatment decreased the mRNA levels of interleukin (IL)-6, IL-1beta, IL-8, monocyte chemoattractant protein-1, toll-like receptor-2, tumor necrosis factor alpha, cyclooxygenase-2, and interferon gamma-induced protein-10.	peonidin	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
27558640-4	2016	In vitro, treatment with ramalin produced significantly less inflammatory chemokines and cytokines, including TARC, MCP-1, RANTES, and IL-8 in TNF-alpha-stimulated HaCaT cells.	Ramalin	25-32	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
27892491-9	2016	IL-1alpha and IL-8, HSPA1A and FOSL1 were significantly upregulated following 24-h treatment with CuCl2 and Cu(OAc)2 at 58 and 580 muM without concomitant inhibition in cell viability.	cupric chloride	98-103	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
27349353-8	2016	The anti-inflammatory potency of DXM-loaded CMS (10-E-15-350) nanocarriers was assessed in TNFalpha supplemented skin models, where a significant reduction of the pro-inflammatory cytokine IL-8 was seen, with markedly greater efficacy than commercial DXM cream.	Dexamethasone	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
27886000-15	2016	CONCLUSIONS: In this study, micro layered esthetic nickel titanium wires are found biocompatible among other wires and NaF and CHX mouthwashes can be recommend for their good corrosion resistance during fixed orthodontic therapy.	Nickel	51-57	C-X-C motif chemokine ligand 8	Homo sapiens	119-122
27892491-9	2016	IL-1alpha and IL-8, HSPA1A and FOSL1 were significantly upregulated following 24-h treatment with CuCl2 and Cu(OAc)2 at 58 and 580 muM without concomitant inhibition in cell viability.	cupric acetate	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
27874084-6	2016	Moreover, silymarin attenuated CSE-induced upregulation of inflammatory cytokines TNF-alpha, IL-6 and IL-8 which could also be dampened by ERK/p38 MAPK inhibitors and siRNAs for Beclin-1 and Atg5.	Silymarin	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
27933092-6	2016	The decrease in the CXCL8 level was negatively correlated with the increase in the how-density lipoprotein-cholesterol (HDL-C) level and was positively correlated with the decrease in the soluble P-selectin (sP-selectin) level in the anthocyanin group.	Cholesterol	107-118	C-X-C motif chemokine ligand 8	Homo sapiens	20-25
27933092-6	2016	The decrease in the CXCL8 level was negatively correlated with the increase in the how-density lipoprotein-cholesterol (HDL-C) level and was positively correlated with the decrease in the soluble P-selectin (sP-selectin) level in the anthocyanin group.	TFF2 protein, human	208-210	C-X-C motif chemokine ligand 8	Homo sapiens	20-25
27933092-6	2016	The decrease in the CXCL8 level was negatively correlated with the increase in the how-density lipoprotein-cholesterol (HDL-C) level and was positively correlated with the decrease in the soluble P-selectin (sP-selectin) level in the anthocyanin group.	Anthocyanins	234-245	C-X-C motif chemokine ligand 8	Homo sapiens	20-25
27835611-4	2016	We also studied the role of TLR4 in Co2+-mediated adhesion molecule expression in MonoMac 6 macrophages.We show that Co2+ increases secretion of inflammatory cytokines, including IL-6 and IL-8, in HMEC-1.	Cobalt(2+)	117-121	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
27956797-13	2016	We also showed that subjects with CD seem to have a lowered production of IL8 in response to MDP in the presence of LB.	lb	116-118	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
27849035-8	2016	Sodium iodate also increased expression of FGF-2, but suppressed expression of IL-8, PDGF, TIMP-2 and VEGF.	sodium iodate	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
27869178-9	2016	We conclude that interactions of nickel ions with histidine residues in domain B help to maintain the conformation of the C-terminal region to conserve the integrity of the HpGroES structure and modulate IL-8 release.	Nickel	33-39	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
27869178-9	2016	We conclude that interactions of nickel ions with histidine residues in domain B help to maintain the conformation of the C-terminal region to conserve the integrity of the HpGroES structure and modulate IL-8 release.	Histidine	50-59	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
27575568-6	2016	As a result from the inflammatory response, IPOH [50muM] induced an increase of both IL-6 and IL-8 secretion in A549 (1.5-fold change) and in 16HBE14o- (2.8- and 7-fold change respectively).	ipoh	44-48	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
27575568-7	2016	4-OPA [50muM] treatment of A549 increased IL-6 (1.4-times) and IL-8 (1.3-times) levels, while in 16HBE14o- had an opposite effect.	4-oxopentanal	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
27575568-8	2016	A549 treated with 4-AMCH [50muM] elevate both IL-6 and IL-8 levels by 1.2-times, while in 16HBE14o- had an opposite effect.	4-acetyl-1-methylcyclohexene	18-24	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
27740938-0	2016	7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells.	7-ketocholesterol	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
27852250-11	2016	Greater inhibition of IL-8 production was observed in neutrophils from patients with SS asthma treated with DEX/atopic asthmatic serum combination compared with SR asthma patients, though DEX alone showed the same effect on neutrophils from SS and SR asthma patients.	Dexamethasone	108-111	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
27904665-11	2016	(3) ELISA showed IL-8 in the supernatant increased significantly in a time dependent manner after HCY treatment (P&lt;0.01), but curcumin could significantly inhibit the IL-8 secretion in endothelial cells after HCY treatment.	Homocysteine	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
27904665-11	2016	(3) ELISA showed IL-8 in the supernatant increased significantly in a time dependent manner after HCY treatment (P&lt;0.01), but curcumin could significantly inhibit the IL-8 secretion in endothelial cells after HCY treatment.	Curcumin	129-137	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
27904665-13	2016	CONCLUSION: Curcumin is able to protect the endothelial cells against HCY induced injury through inhibiting NF-kappaB activation and down-regulating IL-8 expression.	Curcumin	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
27849062-4	2016	Herein, we show that FTY720-P enhances TNF-induced PP2A phosphatase activity and significantly represses TNF-induced interleukin 6 (IL-6) and IL-8 mRNA expression and protein secretion from A549 lung epithelial cells.	FTY 720P	21-29	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
27740938-10	2016	LY294002 attenuated the 7-KC-induced apoptosis and IL-8 mRNA expression of endothelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
27713966-0	2016	Hydroxysafflor yellow A inhibits IL-1beta-induced release of IL-6, IL-8, and MMP-1 via suppression of ERK, NF-kappaB and AP-1 signaling in SW982 human synovial cells.	hydroxysafflor yellow A	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
27877060-6	2016	RESULTS: In a keratinocyte model, ES0 inhibited the expression of the inflammatory mediators, thymic stromal lymphopoietin, interleukin (IL)-18, IL-4R, IL-8, monocyte chemoattractant protein-3, macrophage inflammatory protein-3alpha, and macrophage-derived chemokine and induced the expression of involucrin, which is involved in skin barrier keratinocyte terminal differentiation.	2-amino-1H-Benzimidazol-7-ol	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	152-156
27713966-7	2016	These results indicate that the inhibitory effects of HSYA on IL-1beta-induced IL-6, IL-8 and MMP-1 release might be mediated via suppression of ERK, nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) signaling pathways.	hydroxysafflor yellow A	54-58	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
27398628-4	2016	One of these is based on the use of the old sulfone antibiotic dapsone that has demonstrated several interleukin-8 system inhibiting actions.	Sulfones	44-51	C-X-C motif chemokine ligand 8	Homo sapiens	101-114
27753495-3	2016	We found the transition concentration is ion-specific, and the capacity of sodium halide salts to inhibit bubble coalescence follows the order of NaF &gt; NaCl &gt; NaBr &gt; NaI.	sodium halide salts	75-94	C-X-C motif chemokine ligand 8	Homo sapiens	146-149
27753495-3	2016	We found the transition concentration is ion-specific, and the capacity of sodium halide salts to inhibit bubble coalescence follows the order of NaF &gt; NaCl &gt; NaBr &gt; NaI.	Sodium Chloride	155-159	C-X-C motif chemokine ligand 8	Homo sapiens	146-149
27753495-3	2016	We found the transition concentration is ion-specific, and the capacity of sodium halide salts to inhibit bubble coalescence follows the order of NaF &gt; NaCl &gt; NaBr &gt; NaI.	sodium bromide	165-169	C-X-C motif chemokine ligand 8	Homo sapiens	146-149
27753495-3	2016	We found the transition concentration is ion-specific, and the capacity of sodium halide salts to inhibit bubble coalescence follows the order of NaF &gt; NaCl &gt; NaBr &gt; NaI.	Sodium Iodide	175-178	C-X-C motif chemokine ligand 8	Homo sapiens	146-149
27281349-5	2016	Budesonide suppressed secreted chemokines IL-8 and CCL2 (MCP-1) within 4 hours, reaching a 90% decrease at 12 hours, which was fully reversed 72 hours after removal of the steroid.	Budesonide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
27890374-6	2016	The serum concentrations of IL-8 from MASP group and SAP group obviously increased at day 1, and there was significant difference between MASP group and MAP group, SAP group and MSAP group (P &lt; 0.05), while the difference between MAP group and control group was not obvious (P &gt; 0.05); The serum concentrations of MCP-1, TNF-alpha and IL-8 from MAP group all reached the highest level at day 4, which were significantly higher than the detection levels at day 1.	msap	178-182	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
27890374-7	2016	In MSAP group and SAP group, the serum concentrations of MCP-1, TNF-alpha and IL-8 were the highest at day 1, which were significantly higher than the detection levels at day 4 and 7.	msap	3-7	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
27890374-8	2016	At each detecting timing, the serum concentrations of MCP-1, TNF-alpha and IL-8 from MSAP group and SAP group were all higher than those of MAP group and MSAP group, respectively.	msap	85-89	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
26147617-9	2016	In the symptomatic group, the mean 18F-NaF TBR was 2 12 +- 0 44, and in the asymptomatic group, it was 1 85 +- 0 46.	tbr	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
26147617-10	2016	The 18F-NaF/18F-FDG showed that, overall, 18F-NaF uptake is higher than 18F-FDG.	Fluorodeoxyglucose F18	12-19	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
26147617-10	2016	The 18F-NaF/18F-FDG showed that, overall, 18F-NaF uptake is higher than 18F-FDG.	Fluorodeoxyglucose F18	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
26147617-11	2016	In the symptomatic plaques, the 18F-NaF was higher for the low calcium content and the lowest for the high.	Calcium	63-70	C-X-C motif chemokine ligand 8	Homo sapiens	36-39
27655676-4	2016	Using an under agarose chemotaxis assay, we observed that the bacterial fMLP-induced neutrophil chemotaxis signal overrode interleukin 8 (IL-8)- and leukotriene B4 (LTB4)-induced chemotaxis signals.	Sepharose	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	123-136
27655676-4	2016	Using an under agarose chemotaxis assay, we observed that the bacterial fMLP-induced neutrophil chemotaxis signal overrode interleukin 8 (IL-8)- and leukotriene B4 (LTB4)-induced chemotaxis signals.	Sepharose	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
27591243-13	2016	14,15-EET treatment resulted in a significant reduction in IL-6, IL-8, and MCP-1 secretion, and increased accumulation of Nrf2 and expression of HO-1.	14,15-epoxy-5,8,11-eicosatrienoic acid	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
27890374-9	2016	CONCLUSIONS: The dynamic changes of serum levels of MCP-1, TNF-alpha and IL-8 in patients with acute pancreatitis have their rules, and the change rule of MAP group was different with that of MSAP and SAP group, which showed the reference value for the diagnosis and illness severity evaluation of acute pancreatitis.	msap	192-196	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
27398628-4	2016	One of these is based on the use of the old sulfone antibiotic dapsone that has demonstrated several interleukin-8 system inhibiting actions.	Dapsone	63-70	C-X-C motif chemokine ligand 8	Homo sapiens	101-114
27398628-5	2016	Erlotinib typically gives a rash that has recently been proven to come out via up-regulated keratinocyte interleukin-8 synthesis with histological features reminiscent of typical neutrophilic dermatoses.	Erlotinib Hydrochloride	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	105-118
27398628-6	2016	In this review, we report experimental evidence that shows the use of dapsone to improve quality of life in erlotinib-treated patients by ameliorating rash as well as short-circuiting a growth-enhancing aspect of erlotinib based on increased interleukin-8 secretion.	Dapsone	70-77	C-X-C motif chemokine ligand 8	Homo sapiens	242-255
27398628-6	2016	In this review, we report experimental evidence that shows the use of dapsone to improve quality of life in erlotinib-treated patients by ameliorating rash as well as short-circuiting a growth-enhancing aspect of erlotinib based on increased interleukin-8 secretion.	Erlotinib Hydrochloride	108-117	C-X-C motif chemokine ligand 8	Homo sapiens	242-255
27882140-11	2016	Thus, HES 130/0.4 resuscitation could decrease the IL-1 and IL-8 levels, shorten the duration of positive FB, and preserve the patient"s immune status as well as renal function during the early phase of SAP.	Hydroxyethyl Starch Derivatives	6-9	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
27404512-7	2016	Using an ELISArray approach for the simultaneous detection of several analytes (cytokines/chemokines), it was found that only ZnO and AgNP20 increased the production of different analytes including the potent pro-inflammatory CXCL8 (IL-8) chemokine.	Zinc Oxide	126-129	C-X-C motif chemokine ligand 8	Homo sapiens	226-231
27598863-9	2016	Pearson correlation exhibited a relationship between the ABTS assay and the expression of three out of five analyzed genes; IL-1beta, IL-6 and IL-8.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	57-61	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
27012464-9	2016	MPAID also inhibited TNF-alpha-induced NF-kappaB transcriptional activity, the mRNA expression of IL-6 and IL-8, and IL-6 production.	mpaid	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
26744271-0	2016	Elevated mRNA expression of PGF2alpha receptor splice variant 2(FP-V2) in human decidua is associated with incomplete mifepristone-misoprostol-induced early medical abortion by regulation of interleukin-8.	Misoprostol	131-142	C-X-C motif chemokine ligand 8	Homo sapiens	191-204
27404512-7	2016	Using an ELISArray approach for the simultaneous detection of several analytes (cytokines/chemokines), it was found that only ZnO and AgNP20 increased the production of different analytes including the potent pro-inflammatory CXCL8 (IL-8) chemokine.	Zinc Oxide	126-129	C-X-C motif chemokine ligand 8	Homo sapiens	233-237
27542947-17	2016	However, the secretion patterns of hIGF1 and IL8 differed in the luteal phase when comparing steroid treatment with follicle co-culture.	Steroids	93-100	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
27538572-4	2016	In primary human cell cultures, we found that hepta-1855 functioned as a potent TLR4 agonist by priming neutrophil respiratory burst and stimulating strong IL-8 from monocytes and neutrophils.	hepta-1855	46-56	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
27538572-8	2016	We found that penta-1447 lacked immunostimulatory activity but interfered with inflammatory IL-8 synthesis in response to hexa-1685.	PENTA	14-19	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
27538572-9	2016	Together, these observations suggest a potential contribution of hepta-1855 to maintenance of the inflammatory burden in late-stage CF by recruiting neutrophils via IL-8 and promoting their survival, an effect presumably amplified by the absence of penta-1447.	hepta-1855	65-75	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
26558835-5	2016	The long-distance sculling intensity variables such as the average rating of perceived exertion, HR and blood lactate were correlated with changes in IL-8, IL-1alpha and IL-1beta levels (r=0.47 to r=0.59; P&lt;0.05).	Lactic Acid	110-117	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
27861337-9	2016	The changes in IL-8 also differed significantly between LDV/SOF + RBV and LDV/SOF groups (P &lt; 0.05).	Ribavirin	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
27345703-9	2016	Interleukin-8 (IL-8) release was increased by all particulates, avobenzone, homosalate and octylsalicylate.	avobenzone	64-74	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
27345703-9	2016	Interleukin-8 (IL-8) release was increased by all particulates, avobenzone, homosalate and octylsalicylate.	avobenzone	64-74	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
27345703-9	2016	Interleukin-8 (IL-8) release was increased by all particulates, avobenzone, homosalate and octylsalicylate.	homosalate and octylsalicylate	76-106	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
27345703-9	2016	Interleukin-8 (IL-8) release was increased by all particulates, avobenzone, homosalate and octylsalicylate.	homosalate and octylsalicylate	76-106	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
27542947-19	2016	In co-culture, IL8 secretion was also suppressed on luteal phase day 15 (P = 0.013) versus follicular phase day 7, but IL8 secretion increased continuously under high E2/progesterone treatment (P = 0.003 for D13 versus D3).	Progesterone	170-182	C-X-C motif chemokine ligand 8	Homo sapiens	119-122
27287090-13	2016	Lysed neutrophils inhibited RV16-induced IL-6 and CXCL8 from monocytes.	rv16	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	50-55
27490714-7	2016	RESULTS: Following intramuscular capsaicin injection, pro-inflammatory cytokines [TNFalpha, IL-6, IL-8] significantly increased (percent rise from baseline) in both groups, whereas IL-1beta significantly increased in the PTSD group only.	Capsaicin	33-42	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
27494070-8	2016	In vitro, dexamethasone reduced the IL-8-mediated release of MMP-9 from neutrophils, indicating that glucocorticoids may exert rapid effects on neutrophil activation.	Dexamethasone	10-23	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
27287090-14	2016	Neutrophil intracellular components alone effectively inhibited RV16-induced monocyte-derived IL-6 and CXCL8.	rv16	64-68	C-X-C motif chemokine ligand 8	Homo sapiens	103-108
27287090-15	2016	Neutrophil intracellular components reduced RV16-induced IL-6 and CXCL8 mRNA in monocytes.	rv16	44-48	C-X-C motif chemokine ligand 8	Homo sapiens	66-71
27770804-9	2016	Dust extract induction of IL-8 gene expression was associated with increased DHE-fluorescence and 4-HNE staining, and antioxidants suppressed inflammatory gene induction.	dihydroethidium	77-80	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
27852393-5	2016	Results: The mRNA levels of Acanthamoeba-induced TLR4, MyD88, NF-kappaB, TNF-alpha, IFN-beta and IL-8 in THCEs under hypoxia was down-regulated by 47%, 41%, 45%, 53%, 36% and 50% respectively, compared to control group.	thces	105-110	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
27791031-6	2016	IL-8 knockdown inhibits tamoxifen-resistant cell growth and invasion and partially attenuates the effect of overexpressed FOXA1.	Tamoxifen	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
27776166-7	2016	Furthermore, GlcN suppressed the expression of proinflammatory cytokine genes (such as IL-6, IL-8, IL-24 and TNF-alpha genes).	Glucosamine	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
27664576-9	2016	The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs.	Cystathionine	32-47	C-X-C motif chemokine ligand 8	Homo sapiens	156-161
27664576-9	2016	The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs.	Cysteine	52-62	C-X-C motif chemokine ligand 8	Homo sapiens	156-161
27664576-9	2016	The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs.	Formaldehyde	79-91	C-X-C motif chemokine ligand 8	Homo sapiens	156-161
27768727-8	2016	In patients with a history of peritonitis (5 of 20), AlaGln supplementation decreased dialysate interleukin-8 levels.	alanylglutamine	53-59	C-X-C motif chemokine ligand 8	Homo sapiens	96-109
27776166-8	2016	In addition, GlcN-mediated O-GlcNAc modification was involved in the downregulation of TNF-alpha and IL-8 genes but not IL-6 and IL-24 genes, based on the effects of alloxan, an O-GlcNAc transferase inhibitor.	Glucosamine	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
27776166-8	2016	In addition, GlcN-mediated O-GlcNAc modification was involved in the downregulation of TNF-alpha and IL-8 genes but not IL-6 and IL-24 genes, based on the effects of alloxan, an O-GlcNAc transferase inhibitor.	o-glcnac	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
27980779-8	2016	Conversely, several immunological effects of ProMune  like IL-8 secretion are independent of CG-motifs and could be ascribed to the phosphorothioate-modifications of its DNA backbone, which may have caused the side effects of ProMune  in clinical trials.	Parathion	132-148	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
27799756-5	2016	OBJECTIVE: The objective of the study was to test whether the daily inhalation of the registered ectoine-containing medical device (Ectoin  inhalation solution) leads to a reduction of neutrophilic cells and interleukin-8 (IL-8) levels in the sputum of persons with mild symptoms of airway disease due to lifelong exposure to environmental air pollution.	ectoine	97-104	C-X-C motif chemokine ligand 8	Homo sapiens	208-221
27799756-5	2016	OBJECTIVE: The objective of the study was to test whether the daily inhalation of the registered ectoine-containing medical device (Ectoin  inhalation solution) leads to a reduction of neutrophilic cells and interleukin-8 (IL-8) levels in the sputum of persons with mild symptoms of airway disease due to lifelong exposure to environmental air pollution.	ectoine	97-104	C-X-C motif chemokine ligand 8	Homo sapiens	223-227
27700067-3	2016	The best estimates of the Gibbs free energies characterizing the AlF4- and NaF2- fragmentation reactions in a water solvent are evaluated as equal to 33-34 and 12-14 kcal/mol, respectively (assuming the F- and AlF3/NaF products) or 14-15 and 26-28 kcal/mol, respectively (assuming the HF and AlF3OH-/NaFOH- products).	Water	110-115	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
27700067-3	2016	The best estimates of the Gibbs free energies characterizing the AlF4- and NaF2- fragmentation reactions in a water solvent are evaluated as equal to 33-34 and 12-14 kcal/mol, respectively (assuming the F- and AlF3/NaF products) or 14-15 and 26-28 kcal/mol, respectively (assuming the HF and AlF3OH-/NaFOH- products).	nafoh	300-305	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
27455900-6	2016	Results from enzyme linked immunosorbent assays revealed that 1,8-cineole suppressed LPS-induced secretion of interleukin-6 and interleukin-8, and recovered nitric oxide to normal levels.	Eucalyptol	62-73	C-X-C motif chemokine ligand 8	Homo sapiens	128-141
27716424-7	2016	In BEAS-2B cells, both SE-A and SE-R inhibited the increase in production of the inflammatory cytokines IL-6 and IL-8.	se-a	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
27125951-3	2016	Additional tracers such as 18F-sodium fluoride (18F-NaF) provide additional avenues for characterizing atherosclerosis development.	18f-sodium fluoride	27-46	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
27739445-6	2016	Using ex vivo human CRC explants, quininib significantly reduced the secretions of IL-6, IL-8, VEGF, ENA-78, GRO-alpha, TNF, IL-1beta and MCP-1 ex vivo (all values p &lt; 0.01).	quininib	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
27716424-7	2016	In BEAS-2B cells, both SE-A and SE-R inhibited the increase in production of the inflammatory cytokines IL-6 and IL-8.	Serine	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
27705794-7	2016	Finally, gene expression and epistasis analysis indicated that CXCL8(IL-8) was a functional target of vitamin D3-mediated HSPC regulation.	Cholecalciferol	102-112	C-X-C motif chemokine ligand 8	Homo sapiens	63-68
27705794-7	2016	Finally, gene expression and epistasis analysis indicated that CXCL8(IL-8) was a functional target of vitamin D3-mediated HSPC regulation.	Cholecalciferol	102-112	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
27104742-11	2016	IL-6 and IL-8 release in unstimulated cultures was higher for CPT-isolated PBMCs compared to Ficoll- and SepMate-isolated PBMCs.	sepmate	105-112	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
27867948-0	2016	Supra-therapeutic plasma concentrations of haloperidol induce moderate inhibition of lipopolysaccharide-induced interleukin-8 release in human monocytes.	Haloperidol	43-54	C-X-C motif chemokine ligand 8	Homo sapiens	112-125
27867948-4	2016	This study examined the effects of the mood-stabilizing drugs carbamazepine and valproic acid and of the antipsychotic drugs olanzapine, risperidone and haloperidol on the production of the pro-inflammatory chemokine interleukin-8 (IL-8), which is released from human monocytes when activated by Gram-negative lipopolysaccharide (LPS).	Haloperidol	153-164	C-X-C motif chemokine ligand 8	Homo sapiens	217-230
27867948-4	2016	This study examined the effects of the mood-stabilizing drugs carbamazepine and valproic acid and of the antipsychotic drugs olanzapine, risperidone and haloperidol on the production of the pro-inflammatory chemokine interleukin-8 (IL-8), which is released from human monocytes when activated by Gram-negative lipopolysaccharide (LPS).	Haloperidol	153-164	C-X-C motif chemokine ligand 8	Homo sapiens	232-236
27867948-7	2016	RESULTS: At supra-therapeutic concentrations of 100 microM, haloperidol inhibited the LPS-induced release of IL-8 in peripheral human monocytes moderately, whereas olanzapine, risperidone, carbamazepine and valproic acid showed no such effect.	Haloperidol	60-71	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
27455449-11	2016	Proteasome inhibitors, bortezomib and MG132, enhanced IL-8 production in both sides, apical and basolateral.	Bortezomib	23-33	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
27455449-11	2016	Proteasome inhibitors, bortezomib and MG132, enhanced IL-8 production in both sides, apical and basolateral.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	38-43	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
27560195-7	2016	The polyphenol intervention significantly reduced the levels of VEGF, ROS, IL-8 and ICAM-1, with a more pronounced effect in TNF-alpha-activated endothelial cells.	Polyphenols	4-14	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
27281236-6	2016	The results showed that OEA suppressed the expression of interleukin-6, interleukin-8, vascular adhesion molecule-1, and intercellular adhesion molecule-1 in a dose-dependent manner.	N-oleoylethanolamine	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	72-85
27503790-6	2016	K1 inhibited both TNF- and phorbol 12-myristate 13-acetate (PMA)-induced NF-kappaB activation, as detected by transcription of synthetic (e.g. luciferase) and natural (e.g. CXCL8) genes controlled by NF-kappaB.	Tetradecanoylphorbol Acetate	27-58	C-X-C motif chemokine ligand 8	Homo sapiens	173-178
27503790-6	2016	K1 inhibited both TNF- and phorbol 12-myristate 13-acetate (PMA)-induced NF-kappaB activation, as detected by transcription of synthetic (e.g. luciferase) and natural (e.g. CXCL8) genes controlled by NF-kappaB.	Tetradecanoylphorbol Acetate	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	173-178
27423378-11	2016	Low IL-8 level (p=0.053) was marginally associated with platinum resistant disease.	Platinum	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
27694173-6	2016	In summary, 18F-NaF PET/CT is a highly sensitive method, but 18F-fluorocholine PET/CT can detect early bone marrow metastases and provide greater specificity in the detection of bone metastases in patients with prostate cancer.	Fluorine-18	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	16-19
27452280-0	2016	Human eosinophils are direct targets to nanoparticles: Zinc oxide nanoparticles (ZnO) delay apoptosis and increase the production of the pro-inflammatory cytokines IL-1beta and IL-8.	Zinc Oxide	55-65	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
27599556-7	2016	Heparin also decreased the TNF-alpha-induced mRNA and protein expression levels of IL-6, IL-8, TNF-alpha and cyclin D1 in a dose-dependent manner.	Heparin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
27473010-9	2016	CONCLUSION: MCZ may have preventive roles in the clinical management of IP in ELBWI by the suppression of IL-8 and HMGB-1.	Miconazole	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
27427241-4	2016	Exposure to Cd(2+), Zn(2+) and As(3+) induced CXCL8 and IL-6 release at concentrations below 100muM, and Mn(2+) and Ni(2+) at concentrations above 200muM.	Cadmium	12-14	C-X-C motif chemokine ligand 8	Homo sapiens	46-51
27427241-4	2016	Exposure to Cd(2+), Zn(2+) and As(3+) induced CXCL8 and IL-6 release at concentrations below 100muM, and Mn(2+) and Ni(2+) at concentrations above 200muM.	Zinc	20-22	C-X-C motif chemokine ligand 8	Homo sapiens	46-51
27309886-0	2016	Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of IL-1, IL-6 and IL-8 in patients with fibromyalgia: A randomized double-blind study.	Lidocaine	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
27206713-8	2016	RESULTS: Exposure of monocytes/macrophages to MSU crystals alone induced the moderate release of IL-8 but not of IL-1beta.	Uric Acid	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
27427241-7	2016	The most potent metals, Cd(2+), Zn(2+) and As(3+) induced highest levels of oxidative activity, and ROS appeared to be central in their CXCL8 and IL-6 responses.	Cadmium	24-26	C-X-C motif chemokine ligand 8	Homo sapiens	136-141
27427241-7	2016	The most potent metals, Cd(2+), Zn(2+) and As(3+) induced highest levels of oxidative activity, and ROS appeared to be central in their CXCL8 and IL-6 responses.	Arsenic	43-45	C-X-C motif chemokine ligand 8	Homo sapiens	136-141
27427241-7	2016	The most potent metals, Cd(2+), Zn(2+) and As(3+) induced highest levels of oxidative activity, and ROS appeared to be central in their CXCL8 and IL-6 responses.	ros	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	136-141
27427241-9	2016	However, the NF-kappaB pathway appeared predominately to be involved only in Zn(2+)- and As(3+)-induced CXCL8 and IL-6 responses.	Zinc	77-79	C-X-C motif chemokine ligand 8	Homo sapiens	104-109
27452280-0	2016	Human eosinophils are direct targets to nanoparticles: Zinc oxide nanoparticles (ZnO) delay apoptosis and increase the production of the pro-inflammatory cytokines IL-1beta and IL-8.	Zinc Oxide	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
27452280-7	2016	In addition, ZnO were found to increase the production of the proinflammatory IL-1beta and IL-8 cytokines.	Zinc Oxide	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
27452280-8	2016	Using a pharmacological approach, we demonstrated that inhibition of caspase-1 reversed the ability of ZnO to induce IL-1beta and IL-8 production, whereas inhibition of caspase-4 only reversed that of IL-8.	Zinc Oxide	103-106	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
27108256-8	2016	The independent sensing platform of Fe(2+), Fe(3+), and Cu(2+)could be established by using NaF as a complexing agent and by regulating the reaction time between NaF and metal ions.	ammonium ferrous sulfate	36-42	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
27040396-8	2016	Interestingly, the latter response was driven by CXCL8 autocrine signaling because it was abolished by SB225002, an antagonist that prevents CXCL8 from binding to CXCR2.	SB 225002	103-111	C-X-C motif chemokine ligand 8	Homo sapiens	49-54
27040396-8	2016	Interestingly, the latter response was driven by CXCL8 autocrine signaling because it was abolished by SB225002, an antagonist that prevents CXCL8 from binding to CXCR2.	SB 225002	103-111	C-X-C motif chemokine ligand 8	Homo sapiens	141-146
27531902-9	2016	IL-8 released by cancer cells also activated pancreatic stellate cell (PSC) to increase GEM resistance.	gemcitabine	88-91	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
27296843-3	2016	SMG was either incorporated within the alginate microbeads or used as a secondary coat on poly-l-lysine (PLL)-containing microcapsules, resulting in reduction of the inflammatory cytokines (IL-1beta, TNF, IL-6, IL-8, MIP-1alpha).	N-SUCCINYL METHIONINE	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	211-215
27586050-4	2016	In addition, treatment of neutrophils with beta-pinene, sabinene, gamma-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca(2+)]i flux and inhibited fMLF-induced chemotaxis.	beta-pinene	43-54	C-X-C motif chemokine ligand 8	Homo sapiens	180-193
27586050-4	2016	In addition, treatment of neutrophils with beta-pinene, sabinene, gamma-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca(2+)]i flux and inhibited fMLF-induced chemotaxis.	beta-pinene	43-54	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
27586050-4	2016	In addition, treatment of neutrophils with beta-pinene, sabinene, gamma-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca(2+)]i flux and inhibited fMLF-induced chemotaxis.	sabinene	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	180-193
27586050-4	2016	In addition, treatment of neutrophils with beta-pinene, sabinene, gamma-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca(2+)]i flux and inhibited fMLF-induced chemotaxis.	sabinene	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
27586050-4	2016	In addition, treatment of neutrophils with beta-pinene, sabinene, gamma-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca(2+)]i flux and inhibited fMLF-induced chemotaxis.	gamma-terpinene	66-81	C-X-C motif chemokine ligand 8	Homo sapiens	180-193
27586050-4	2016	In addition, treatment of neutrophils with beta-pinene, sabinene, gamma-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca(2+)]i flux and inhibited fMLF-induced chemotaxis.	gamma-terpinene	66-81	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
27586050-4	2016	In addition, treatment of neutrophils with beta-pinene, sabinene, gamma-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca(2+)]i flux and inhibited fMLF-induced chemotaxis.	geranylacetone	83-97	C-X-C motif chemokine ligand 8	Homo sapiens	180-193
27586050-4	2016	In addition, treatment of neutrophils with beta-pinene, sabinene, gamma-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca(2+)]i flux and inhibited fMLF-induced chemotaxis.	geranylacetone	83-97	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
27586050-4	2016	In addition, treatment of neutrophils with beta-pinene, sabinene, gamma-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca(2+)]i flux and inhibited fMLF-induced chemotaxis.	pichtosin	103-120	C-X-C motif chemokine ligand 8	Homo sapiens	180-193
27586050-4	2016	In addition, treatment of neutrophils with beta-pinene, sabinene, gamma-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca(2+)]i flux and inhibited fMLF-induced chemotaxis.	pichtosin	103-120	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
27586050-7	2016	In contrast, myristicin inhibited neutrophil [Ca(2+)]i flux stimulated by fMLF and IL-8 and inhibited capsaicin-induced Ca(2+) influx in TRPV1-transfected HEK293 cells.	myristicin	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
27108256-8	2016	The independent sensing platform of Fe(2+), Fe(3+), and Cu(2+)could be established by using NaF as a complexing agent and by regulating the reaction time between NaF and metal ions.	ammonium ferrous sulfate	36-42	C-X-C motif chemokine ligand 8	Homo sapiens	162-165
27108256-8	2016	The independent sensing platform of Fe(2+), Fe(3+), and Cu(2+)could be established by using NaF as a complexing agent and by regulating the reaction time between NaF and metal ions.	ferric sulfate	44-50	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
27108256-8	2016	The independent sensing platform of Fe(2+), Fe(3+), and Cu(2+)could be established by using NaF as a complexing agent and by regulating the reaction time between NaF and metal ions.	ferric sulfate	44-50	C-X-C motif chemokine ligand 8	Homo sapiens	162-165
27108256-8	2016	The independent sensing platform of Fe(2+), Fe(3+), and Cu(2+)could be established by using NaF as a complexing agent and by regulating the reaction time between NaF and metal ions.	cupric ion	56-62	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
27108256-8	2016	The independent sensing platform of Fe(2+), Fe(3+), and Cu(2+)could be established by using NaF as a complexing agent and by regulating the reaction time between NaF and metal ions.	cupric ion	56-62	C-X-C motif chemokine ligand 8	Homo sapiens	162-165
27108256-8	2016	The independent sensing platform of Fe(2+), Fe(3+), and Cu(2+)could be established by using NaF as a complexing agent and by regulating the reaction time between NaF and metal ions.	Metals	170-175	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
27108256-8	2016	The independent sensing platform of Fe(2+), Fe(3+), and Cu(2+)could be established by using NaF as a complexing agent and by regulating the reaction time between NaF and metal ions.	Metals	170-175	C-X-C motif chemokine ligand 8	Homo sapiens	162-165
27397760-8	2016	In conclusion, ceftaroline is able to counteract the effects of CSE on the innate immunity and pro-inflammatory responses modulating TLR2, LPS binding, NFkB activation and activity, HBD2 and IL-8 expression in bronchial epithelial cells.	T 91825	15-26	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
27604412-6	2016	The ensuing Ca(2+) entry then activates NFAT/calcineurin signaling to induce transcriptional production of the proinflammatory cytokines IL-6 and IL-8.	nfat	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
27515449-2	2016	Previous studies have demonstrated that both TLR2 agonists Pam3CSK4 and PGN stimulated IL-8 release in human mast cells.	pgn	72-75	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
28028949-10	2016	CONCLUSIONS: In COP patients, response to clarithromycin treatment was associated with decreases in serum concentrations of IL-6, IL-8 and TGF-beta, and of rations, and of the BAL-f concentration of IL-6.	Clarithromycin	42-56	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
27397760-6	2016	Ceftaroline counteracted the CSE effect on TLR2 expression, on LPS binding, on IL-8 mRNA, HBD2 and NFkB in 16HBE.	T 91825	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
27490211-12	2016	Tideglusib reported a significant dose-dependent increase in pro-apoptotic proteins (PARP, Caspase-9, Caspase-7, Caspase-3) and tumor-related genes (FasL, TNF-alpha, Cox-2, IL-8, Caspase-3).	tideglusib	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
27260851-7	2016	Besides, DHEA inhibited the anchorage-independent growth on agar and decreased the size of spheroids, and also reduced the secretion of IL-1alpha, IL-6, IL-8, and TNF-alpha in all cell lines.	Dehydroepiandrosterone	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
26641773-4	2016	In this study, we demonstrate that treatment of HL-60 cells with allopurinol significantly increased the mRNA expression levels of interleukin-8, monocyte chemotactic protein-1 and tumor necrosis factor alpha in a time- and concentration-dependent manner.	Allopurinol	65-76	C-X-C motif chemokine ligand 8	Homo sapiens	131-144
27759405-3	2016	24 patients of the test group (TG) rinsed after tooth brushing with a fluoride mouth rinse (100 ppm AmF/150 ppm NaF) while 21 patients of the control group (CG) did not.	fluoride mouth rinse	70-90	C-X-C motif chemokine ligand 8	Homo sapiens	112-115
27593287-8	2016	Cr was positively correlated with both IL-6 and IL-8 release, while Si was only associated with the increase of IL-6.	Chromium	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
27904616-7	2016	After folic acid and metformin administration, mean of Hcy, HOMA-IR, TNF-alpha, and IL-8 decreased significantly (P &lt; 0.05).	Folic Acid	6-16	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
27904616-7	2016	After folic acid and metformin administration, mean of Hcy, HOMA-IR, TNF-alpha, and IL-8 decreased significantly (P &lt; 0.05).	Metformin	21-30	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
27515207-7	2016	Thus, gelsolin inhibits the release of IL-8 from human neutrophils subjected to lipoteichoic acid, lipopolysaccharide and heat-inactivated bacteria treatment.	lipoteichoic acid	80-97	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
27588140-6	2016	Furthermore, IL-8 could induce AKT phosphorylation, and the phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitor LY294002 could inhibit the EMT of RCC cells that was induced by IL-8.	phosphatidylinositol-4,	60-83	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
27484716-7	2016	The results demonstrated that celastrol significantly attenuated the expression of IL-6, IL-8, cyclooxygenase (COX)-2 and intercellular adhesion molecule-1 (ICAM-1), and inhibited IL-1beta-induced increases in the expression of IL-6, IL-8, ICAM-1 and COX-2.	celastrol	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
27484716-7	2016	The results demonstrated that celastrol significantly attenuated the expression of IL-6, IL-8, cyclooxygenase (COX)-2 and intercellular adhesion molecule-1 (ICAM-1), and inhibited IL-1beta-induced increases in the expression of IL-6, IL-8, ICAM-1 and COX-2.	celastrol	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	234-238
27171647-0	2016	High glucose-induced oxidative stress increases IL-8 production in human gingival epithelial cells.	Glucose	5-12	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
27171647-7	2016	Increased IL-8 secretion in HG was inhibited by pretreatment with an antioxidant, N-acetylcysteine, or a protein kinase C inhibitor, Ro31-8220.	Acetylcysteine	82-98	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
27171647-7	2016	Increased IL-8 secretion in HG was inhibited by pretreatment with an antioxidant, N-acetylcysteine, or a protein kinase C inhibitor, Ro31-8220.	Ro 31-8220	133-142	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
28390203-10	2016	The addition of stannous fluoride suppressed production of TNF-a, IFN-g, IL12p70, IL10, IL-1b, IL2, and IL-6, and also increased secretion of Il-8 in dose response fashion.	Tin Fluorides	16-33	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
27540423-8	2016	The applications of F-18 fluorodeoxyglucose (FDG) and F-18 sodium fluoride (NaF) to cardiovascular diseases have revealed details on the basic pathophysiology of ischemic heart diseases.	f-18 sodium fluoride	54-74	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
27588140-6	2016	Furthermore, IL-8 could induce AKT phosphorylation, and the phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitor LY294002 could inhibit the EMT of RCC cells that was induced by IL-8.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
27468646-4	2016	CAM treatment led to a significant reduction in poly I:C- and RSV-mediated IL-8, CCL5, IFN-beta and -lambda production.	Clarithromycin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
27468646-4	2016	CAM treatment led to a significant reduction in poly I:C- and RSV-mediated IL-8, CCL5, IFN-beta and -lambda production.	Poly I	48-54	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
27473819-6	2016	By using pure compounds, we found that casuarictin may act as a pure NF-kappaB inhibitor while agrimoniin inhibits IL-8 secretion also acting on other biological targets; in our system procyanidin B1 prevents the TNFalpha-induced effects without interfering with the NF-kappaB pathway.	agrimoniin	95-105	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
27468646-4	2016	CAM treatment led to a significant reduction in poly I:C- and RSV-mediated IL-8, CCL5, IFN-beta and -lambda production.	Carbon	0-1	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
27216470-6	2016	Tannic acid-modified but not unmodified AgNPs down-regulated TNF-alpha and LPS-triggered production of IL-8 in VK2-E6/E7 but not in HaCaT cells.	Tannins	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
29620823-12	2016	Duraphat (5%NaF) and Clinprotm(5%NaF+TCP) had the highestrelease of fluoride at 3-month evaluation.	sodium fluoride topical preparation	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
29620823-12	2016	Duraphat (5%NaF) and Clinprotm(5%NaF+TCP) had the highestrelease of fluoride at 3-month evaluation.	clinprotm	21-30	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
27311854-5	2016	Although gemcitabine also enhanced CXCL8 expression, anti-CXCL8 antibody failed to reduce gemcitabine-induced increases in SA beta-Gal-positive cell numbers.	gemcitabine	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	35-40
29620823-12	2016	Duraphat (5%NaF) and Clinprotm(5%NaF+TCP) had the highestrelease of fluoride at 3-month evaluation.	Fluorides	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
27557865-3	2016	This study aimed to compare dental stain control of twice-daily brushing with a sodium fluoride (NaF) dentifrice containing 67 % sodium bicarbonate (NaHCO3) or a commercially available NaF silica dentifrice without NaHCO3, while using a mouthwash containing 0.2 % CHX.	Sodium Fluoride	80-95	C-X-C motif chemokine ligand 8	Homo sapiens	97-100
27557865-3	2016	This study aimed to compare dental stain control of twice-daily brushing with a sodium fluoride (NaF) dentifrice containing 67 % sodium bicarbonate (NaHCO3) or a commercially available NaF silica dentifrice without NaHCO3, while using a mouthwash containing 0.2 % CHX.	Silicon Dioxide	189-195	C-X-C motif chemokine ligand 8	Homo sapiens	185-188
27405388-4	2016	In this work, a high-throughput microfluidic platform was developed for the optimization of chromatographic conditions regarding the capture of an anti-interleukin 8 mAb, using a multimodal ligand (2-benzamido-4-mercaptobutanoic acid), under a wide range of buffer pH and conductivities.	SCHEMBL2330376	198-233	C-X-C motif chemokine ligand 8	Homo sapiens	152-165
27571064-12	2016	p38 MAPK inhibitor SB239063 significantly attenuated IL-6 and IL-8 release the most (p &lt;= 0.05).	SB 239063	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
27301357-7	2016	In fact, the effect of bortezomib on IL-8 production was higher than that exerted by stromal-MM cell interactions.	Bortezomib	23-33	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
27529418-7	2016	Additionally, miR-200c delivered using polyethylenimine (PEI) nanoparticles effectively inhibits IL-6, IL-8 and CCL-5 in primary human periodontal ligament fibroblasts and increases the biomarkers of osteogenic differentiation in human bone marrow mesenchymal stem cells (MSCs), including calcium content, ALP, and Runx2.	Polyethyleneimine	39-55	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
27529418-7	2016	Additionally, miR-200c delivered using polyethylenimine (PEI) nanoparticles effectively inhibits IL-6, IL-8 and CCL-5 in primary human periodontal ligament fibroblasts and increases the biomarkers of osteogenic differentiation in human bone marrow mesenchymal stem cells (MSCs), including calcium content, ALP, and Runx2.	Polyethyleneimine	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
27269729-4	2016	In this study, PF6 was shown to form unimodal nanocomplexes with miR-146a mimic that entered into human primary keratinocytes, where miR-146a inhibited the expression of its direct targets from the NF-kappaB pathway and the genes known to be activated by NF-kappaB, C-C motif ligand (CCL)5 and interleukin (IL)-8.	pf6	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	294-312
27240956-4	2016	Under basal conditions CF cells had increased bromodomain (Brd)3 and Brd4 recruitment and enhanced NF-kappaB and C/EBPbeta binding to the CXCL8 promoter compared to non-CF cells due to trimethylation of histone H3 at lysine 4 (H3K4me3) and DNA hypomethylation at CpG6.	Lysine	217-223	C-X-C motif chemokine ligand 8	Homo sapiens	138-143
27301357-6	2016	Interestingly, IL8 expression also increased in HMCLs, stromal cells, and osteoclasts after treatment with the antimyeloma drugs melphalan and bortezomib.	Bortezomib	143-153	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
27216995-7	2016	Efavirenz induced a marked concentration-dependent increase in interleukin-8 expression and release whereas elvitregravir had little effect.	efavirenz	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
27340129-0	2016	Ursodeoxycholic acid inhibits TNFalpha-induced IL-8 release from monocytes.	Ursodeoxycholic Acid	0-20	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
27301549-1	2016	(18)F-sodium fluoride (NaF) as an imaging tracer portrays calcium metabolic activity either in the osseous structures or in soft tissue.	Sodium Fluoride	6-21	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
27301549-6	2016	Several studies have evaluated the efficacy of bisphosphonates and their lasting effects as treatment for osteoporosis using bone turnover measured by NaF-PET.	Diphosphonates	47-62	C-X-C motif chemokine ligand 8	Homo sapiens	151-154
27301549-1	2016	(18)F-sodium fluoride (NaF) as an imaging tracer portrays calcium metabolic activity either in the osseous structures or in soft tissue.	Calcium	58-65	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
27159450-4	2016	We developed a biocompatible, cationic polylactide (CPLA) nanocarrier to complex with and efficiently deliver IL-8 small interfering RNA (siRNA) to CaP cells in vitro and in vivo.	poly(lactide)	39-50	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
27177354-15	2016	The induction of IL-8 in Beas-2B cells was significantly associated with Cu, Ni and Zn and endotoxin.	Copper	73-75	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
27177354-15	2016	The induction of IL-8 in Beas-2B cells was significantly associated with Cu, Ni and Zn and endotoxin.	Zinc	84-86	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
27159450-4	2016	We developed a biocompatible, cationic polylactide (CPLA) nanocarrier to complex with and efficiently deliver IL-8 small interfering RNA (siRNA) to CaP cells in vitro and in vivo.	cpla	52-56	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
27312705-5	2016	First, NS-398, instead of reducing inflammation, appeared to further enhance IL-1beta-mediated COX-2 and IL-8 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	7-13	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
27312705-0	2016	Novel effects of the cyclooxygenase-2-selective inhibitor NS-398 on IL-1beta-induced cyclooxygenase-2 and IL-8 expression in human ovarian granulosa cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	58-64	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
27043920-12	2016	In addition, baicalin also inhibited the productions of inflammatory cytokines such as IL-1beta, IL-6, IL-8 and TNF-alpha and suppressed the phosphorylation of JAK2, STAT5, IKKbeta, IkappaBalpha and the nuclear translocation of NF-kappaB (p65) subunit in LPS-stimulated human mast cells.	baicalin	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
27556215-7	2016	Further studies demonstrated that curcumin treatment (20 muM) significantly inhibited proinflammatory factors, including IL-6, ELAM-1, IL-1alpha, and IL-8, whereas it decreased activities of senescence marker SA-beta-gal, and lowered levels of carbonylated proteins and apoptotic cell numbers.	Curcumin	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
27086089-11	2016	Plasma concentrations of IL-6, IL-8, and TNFalpha, and peritoneal concentrations of IL-6 and IL-8, were significantly lower in the simvastatin group postoperatively.	Simvastatin	131-142	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
27086089-11	2016	Plasma concentrations of IL-6, IL-8, and TNFalpha, and peritoneal concentrations of IL-6 and IL-8, were significantly lower in the simvastatin group postoperatively.	Simvastatin	131-142	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
27312705-8	2016	Flow cytometry analysis demonstrated that NS-398, in combination with IL-1beta, significantly enhanced cell cycle progression involving IL-8.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	42-48	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
26403145-2	2016	We emphasize the role of [18F]-sodium fluoride (NaF) PET/CT as a potential noninvasive tool to identify and differentiate the transthyretin-related cardiac amyloidosis from the light-chain cardiac amyloidosis.	[18f]-sodium fluoride	25-46	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
27234962-7	2016	Furthermore, treatment with 24,25-[OH]2D3 increased IL-1beta, IL-6, and IL-8 expression by HepG2 cells.	24,25-Dihydroxyvitamin D 3	28-41	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
27278862-0	2016	MAPK pathways are involved in the inhibitory effect of berberine hydrochloride on gastric cancer MGC 803 cell proliferation and IL-8 secretion in vitro and in vivo.	berberine chloride	55-78	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
26446985-7	2016	The gingival crevicular fluid IL-8 levels were significantly higher in the S-GAgP group compared with the N-GAgP group and in the S-CP group compared with the N-CP group (p &lt; 0.05); differences between the SG and NG and the SH and NH groups were not statistically significant (p &gt; 0.05).	gagp	77-81	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
26446985-7	2016	The gingival crevicular fluid IL-8 levels were significantly higher in the S-GAgP group compared with the N-GAgP group and in the S-CP group compared with the N-CP group (p &lt; 0.05); differences between the SG and NG and the SH and NH groups were not statistically significant (p &gt; 0.05).	n-gagp	106-112	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
27300134-10	2016	Moreover, palmitic acid stimulated caspase-3 activation and inflammatory cytokine secretion (e.g., IL-6 and IL-8).	Palmitic Acid	10-23	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
27300134-12	2016	In addition, palmitic acid-induced IL-1beta, IL-6, and IL-8 secretion was depended on reactive oxygen species (ROS) generation.	Palmitic Acid	13-26	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
27300134-12	2016	In addition, palmitic acid-induced IL-1beta, IL-6, and IL-8 secretion was depended on reactive oxygen species (ROS) generation.	Reactive Oxygen Species	86-109	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
27300134-12	2016	In addition, palmitic acid-induced IL-1beta, IL-6, and IL-8 secretion was depended on reactive oxygen species (ROS) generation.	Reactive Oxygen Species	111-114	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
27300134-13	2016	In conclusion, palmitic acid caused activation of NLRP3 inflammasomes and inflammatory responses, inducing IL-1beta, IL-6, and IL-8 secretion, which is associated with ROS generation, in human Sw.71 placental cells.	Palmitic Acid	15-28	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
27278862-7	2016	However, there was no significant synergistic inhibitory effect of combined BER and evodiamine (EVO) treatment on tumorigenesis, and BER reduced the upregulation of IL-8 induced by EVO in vivo.	evodiamine	181-184	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
27446449-3	2016	The data showed that atorvastatin decreased the visfatin-induced expression of interleukin (IL)-6 and IL-8 in HCAECs.	Atorvastatin	21-33	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
27271044-5	2016	G1 inhibited the secretion of two proinflammatory cytokines, interleukin (IL)-6 and IL-8, in cells stimulated by adenosine 5"-(gamma-thio)triphosphate (ATPgammaS).	adenosine 5'-O-(3-thiotriphosphate)	113-150	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
27271044-5	2016	G1 inhibited the secretion of two proinflammatory cytokines, interleukin (IL)-6 and IL-8, in cells stimulated by adenosine 5"-(gamma-thio)triphosphate (ATPgammaS).	adenosine 5'-O-(3-thiotriphosphate)	152-161	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
27467268-8	2016	Live imaging demonstrated that in WM-15-treated neutrophils, where homotypic aggregation was evident, the number of cells entering IL-8 impregnated collagen I gels was significantly reduced.	wm-15	34-39	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
27406216-9	2016	Significant differences in basal KC cytokine secretion (IL-1alpha, IL-18, and CXCL8) were only observed between KC-Prim and KC-HPV.	kc-hpv	124-130	C-X-C motif chemokine ligand 8	Homo sapiens	78-83
27335135-4	2016	TP/BF showed highest microTBS, while NaF polymers decreased microTBS.	microtbs	60-68	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
27335135-7	2016	NaF addition enhanced acid resistance but decreased microTBS.	microtbs	52-60	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
27455959-10	2016	In patients, prednisolone abolished symptoms, normalized C-reactive protein, and reduced melatonin, IL-6, IL-8, and TNF-alpha concentrations (2P &lt; 0.05), while IL-10 increased between 10:00 and 14:00.	Prednisolone	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
27453994-6	2016	Treatment with the inflammatory agents lipopolysaccharide (LPS) or palmitate augmented the secretion of many myokines including: GROa, IL6, IL8, IL15, and TNFa, but did not consistently alter the protein content and/or phosphorylation of IkBa, p44/42 MAPK, p38 MAPK, c-Jun N-terminal kinase (JNK) and NF-kB, nor lead to consistent changes in basal and insulin-stimulated glucose uptake or free fatty acid oxidation.	Palmitates	67-76	C-X-C motif chemokine ligand 8	Homo sapiens	140-143
27430279-5	2016	Cholesterol and sphingomyelin-containing liposomes designed to sequester pneumolysin were highly effective at reducing CXCL8 levels from epithelial cells exposed to different clinical pneumococcal isolates.	Cholesterol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	119-124
27389658-3	2016	Here, for the first time, we address the electrochemical actuation and the associated stress-charge coefficients of bulk nanoporous nickel (np-Ni) in both strongly (NaOH) and weakly (NaF) adsorbed electrolytes.	Nickel	132-138	C-X-C motif chemokine ligand 8	Homo sapiens	183-186
27430279-5	2016	Cholesterol and sphingomyelin-containing liposomes designed to sequester pneumolysin were highly effective at reducing CXCL8 levels from epithelial cells exposed to different clinical pneumococcal isolates.	Sphingomyelins	16-29	C-X-C motif chemokine ligand 8	Homo sapiens	119-124
27312995-8	2016	Acidic stimulation increased IL-8 production in LECs, whereas a selective transient receptor potential vanilloid subtype 1 (TRPV1) antagonist, 5"-iodoresiniferatoxin, decreased IL-8 production.	iodoresiniferatoxin	143-165	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
27436995-5	2016	RESULTS: At the non-toxic dosages, chemical compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics dose-dependently increased IL-8 reporter gene expression.	Nicotine	67-75	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
27436995-5	2016	RESULTS: At the non-toxic dosages, chemical compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics dose-dependently increased IL-8 reporter gene expression.	aromatic amines	77-92	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
27436995-5	2016	RESULTS: At the non-toxic dosages, chemical compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics dose-dependently increased IL-8 reporter gene expression.	Benzopyrenes	94-105	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
27436995-5	2016	RESULTS: At the non-toxic dosages, chemical compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics dose-dependently increased IL-8 reporter gene expression.	Phenols	107-114	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
27436995-5	2016	RESULTS: At the non-toxic dosages, chemical compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics dose-dependently increased IL-8 reporter gene expression.	Aldehydes	116-125	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
27436995-6	2016	Consistently, the representative compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics significantly and dose-dependently increased IL-8 levels in the culture supernatants of 16HBE cells, among these compounds, benzopyrene is a most potent stimulator for inducing IL-8 production.	Nicotine	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
27436995-6	2016	Consistently, the representative compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics significantly and dose-dependently increased IL-8 levels in the culture supernatants of 16HBE cells, among these compounds, benzopyrene is a most potent stimulator for inducing IL-8 production.	Nicotine	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	326-330
27436995-6	2016	Consistently, the representative compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics significantly and dose-dependently increased IL-8 levels in the culture supernatants of 16HBE cells, among these compounds, benzopyrene is a most potent stimulator for inducing IL-8 production.	aromatic amines	66-81	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
27436995-6	2016	Consistently, the representative compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics significantly and dose-dependently increased IL-8 levels in the culture supernatants of 16HBE cells, among these compounds, benzopyrene is a most potent stimulator for inducing IL-8 production.	aromatic amines	66-81	C-X-C motif chemokine ligand 8	Homo sapiens	326-330
27436995-6	2016	Consistently, the representative compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics significantly and dose-dependently increased IL-8 levels in the culture supernatants of 16HBE cells, among these compounds, benzopyrene is a most potent stimulator for inducing IL-8 production.	Benzopyrenes	83-94	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
27436995-6	2016	Consistently, the representative compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics significantly and dose-dependently increased IL-8 levels in the culture supernatants of 16HBE cells, among these compounds, benzopyrene is a most potent stimulator for inducing IL-8 production.	Benzopyrenes	83-94	C-X-C motif chemokine ligand 8	Homo sapiens	326-330
27436995-6	2016	Consistently, the representative compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics significantly and dose-dependently increased IL-8 levels in the culture supernatants of 16HBE cells, among these compounds, benzopyrene is a most potent stimulator for inducing IL-8 production.	Phenols	96-103	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
27436995-6	2016	Consistently, the representative compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics significantly and dose-dependently increased IL-8 levels in the culture supernatants of 16HBE cells, among these compounds, benzopyrene is a most potent stimulator for inducing IL-8 production.	Phenols	96-103	C-X-C motif chemokine ligand 8	Homo sapiens	326-330
27436995-6	2016	Consistently, the representative compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics significantly and dose-dependently increased IL-8 levels in the culture supernatants of 16HBE cells, among these compounds, benzopyrene is a most potent stimulator for inducing IL-8 production.	Aldehydes	105-114	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
27436995-6	2016	Consistently, the representative compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics significantly and dose-dependently increased IL-8 levels in the culture supernatants of 16HBE cells, among these compounds, benzopyrene is a most potent stimulator for inducing IL-8 production.	Aldehydes	105-114	C-X-C motif chemokine ligand 8	Homo sapiens	326-330
27436995-6	2016	Consistently, the representative compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics significantly and dose-dependently increased IL-8 levels in the culture supernatants of 16HBE cells, among these compounds, benzopyrene is a most potent stimulator for inducing IL-8 production.	Benzopyrenes	273-284	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
28955928-4	2016	Recent studies have demonstrated that cobalt ions from metal-on-metal joints also activate human TLR4, increasing cellular secretion of inflammatory chemokines including interleukin-8 (IL-8, CXCL8) and CCL2.	Cobalt	38-44	C-X-C motif chemokine ligand 8	Homo sapiens	170-183
28955928-4	2016	Recent studies have demonstrated that cobalt ions from metal-on-metal joints also activate human TLR4, increasing cellular secretion of inflammatory chemokines including interleukin-8 (IL-8, CXCL8) and CCL2.	Cobalt	38-44	C-X-C motif chemokine ligand 8	Homo sapiens	191-196
28955928-4	2016	Recent studies have demonstrated that cobalt ions from metal-on-metal joints also activate human TLR4, increasing cellular secretion of inflammatory chemokines including interleukin-8 (IL-8, CXCL8) and CCL2.	Metals	55-60	C-X-C motif chemokine ligand 8	Homo sapiens	170-183
27415000-11	2016	Importantly, stimulated expression of IL-1beta and IL-8 in HaCaT-TNF-alpha were blocked by Quercetin, a flavanol shown to possess anti-TNF-alpha activities.	Quercetin	91-100	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
27415000-11	2016	Importantly, stimulated expression of IL-1beta and IL-8 in HaCaT-TNF-alpha were blocked by Quercetin, a flavanol shown to possess anti-TNF-alpha activities.	flavanol	104-112	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
28955928-4	2016	Recent studies have demonstrated that cobalt ions from metal-on-metal joints also activate human TLR4, increasing cellular secretion of inflammatory chemokines including interleukin-8 (IL-8, CXCL8) and CCL2.	Metals	55-60	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
28955928-4	2016	Recent studies have demonstrated that cobalt ions from metal-on-metal joints also activate human TLR4, increasing cellular secretion of inflammatory chemokines including interleukin-8 (IL-8, CXCL8) and CCL2.	Metals	55-60	C-X-C motif chemokine ligand 8	Homo sapiens	191-196
28955928-4	2016	Recent studies have demonstrated that cobalt ions from metal-on-metal joints also activate human TLR4, increasing cellular secretion of inflammatory chemokines including interleukin-8 (IL-8, CXCL8) and CCL2.	Cobalt	38-44	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
26990648-0	2016	The differential effects of 1,25-dihydroxyvitamin D3 on Salmonella-induced interleukin-8 and human beta-defensin-2 in intestinal epithelial cells.	Calcitriol	28-52	C-X-C motif chemokine ligand 8	Homo sapiens	75-88
28773666-7	2016	The biosensor based on TiO2/NAF/LAC presented the best electro-chemical properties with regard to sensitivity, stability and detection limit after a period of 22 days.	titanium dioxide	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
28773666-7	2016	The biosensor based on TiO2/NAF/LAC presented the best electro-chemical properties with regard to sensitivity, stability and detection limit after a period of 22 days.	lac	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
27248176-0	2016	IL-8 signaling is involved in resistance of lung carcinoma cells to erlotinib.	Erlotinib Hydrochloride	68-77	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
27248176-4	2016	We report here that generation of erlotinib-resistant lung cancer cells in vitro resulted in a phenotypic alteration reminiscent of an epithelial-mesenchymal transition (EMT) concomitant with a robust upregulation of the IL-8/IL-8R axis.	Erlotinib Hydrochloride	34-43	C-X-C motif chemokine ligand 8	Homo sapiens	221-225
27248176-5	2016	Our results also demonstrate that upregulation of p38 MAPK signaling is responsible for the enhanced IL-8 secretion in the erlotinib-resistant tumor cells.	Erlotinib Hydrochloride	123-132	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
27248176-6	2016	Blockade of IL-8 signaling effectively reduced mesenchymal features of the resistant cells and also markedly enhanced their susceptibility to erlotinib.	Erlotinib Hydrochloride	142-151	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
25532488-6	2016	OTA-induced NO, TNF-alpha, IL-6, and IL-8 were significantly reduced in the quercetin pretreated samples indicating its anti-inflammatory role.	Quercetin	76-85	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
26997430-5	2016	As a bone-specific tracer, there is accumulating evidence to support the use of sodium (18)F-fluoride ((18)F-NaF) PET-CT in the diagnosis of skeletal metastases in breast and prostate cancer, although relatively little data are available to support its use for assessment of treatment response.	sodium (18)f-fluoride	80-101	C-X-C motif chemokine ligand 8	Homo sapiens	109-112
27118044-7	2016	Although there is no evidence that AML pathophysiology is related to hypoxia, leukemic blasts still show several distinct biological features when exposed to reduced pO2: they down- or upregulate membrane receptors such as CXCR4 or FLT3, activate or inhibit intracellular signaling pathways such as PI3K, and specifically secrete cytokines (IL-8).	PO-2	166-169	C-X-C motif chemokine ligand 8	Homo sapiens	341-345
27347105-1	2016	The aim of the retrospective study was to analyze the effect of pioglitazone on the expression of tumor tissue inflammation factor interleukin (IL)-8, macrophage colony-stimulating factor (M-CSF) and vascular endothelial growth factor (VEGF) of type II diabetes in bladder cancer patients.	Pioglitazone	64-76	C-X-C motif chemokine ligand 8	Homo sapiens	131-149
27120567-4	2016	The assay was compared to a bioassay in which tumor necrosis factor-alpha-induced interleukin-8 secretion from HT-29 cells was assessed after addition of IFX to ADA-containing sera or control sera.	N-(2-acetamido)iminodiacetic acid	161-164	C-X-C motif chemokine ligand 8	Homo sapiens	82-95
27308826-10	2016	Interestingly, there was a mean increase in all inflammatory cytokines (IL-1beta, IL-6, and IL-8) during the saline treatment from day 1 to week 3, whereas during the Tyloxapol treatment, all cytokines decreased.	Sodium Chloride	109-115	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
27018308-4	2016	Furthermore, we found that TAM-derived CXCL8 mediated the loss of ERalpha and cancer invasion via HOXB13.	tam	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	39-44
27106081-7	2016	The bromodomain inhibitors effectively decreased etoposide-induced release of IL-6 and IL-8.	Etoposide	49-58	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
27210890-7	2016	KEY FINDINGS: RA significantly inhibited poly(I:C)-induced expression of inflammatory cytokines including IL-1beta, IL-6, IL-8, CCL20, and TNF-alpha, and downregulated NF-kappaB signaling pathway in human keratinocytes.	rosmarinic acid	14-16	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
27210890-7	2016	KEY FINDINGS: RA significantly inhibited poly(I:C)-induced expression of inflammatory cytokines including IL-1beta, IL-6, IL-8, CCL20, and TNF-alpha, and downregulated NF-kappaB signaling pathway in human keratinocytes.	Poly I-C	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
27076634-8	2016	Although dexamethasone treatment reduced RNA polymerase II occupancy of TNF targets such as IL8 and TNFAIP2, we were unable to correlate specific binding sequences for GR or occupancy patterns with repressive effects on transcription.	Dexamethasone	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
27393034-0	2016	Carbon monoxide releasing molecule-2 ameliorates IL-1beta-induced IL-8 in human gastric cancer cells.	Carbon Monoxide	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
27393034-8	2016	Pharmacological inhibition and mutagenesis studies indicated that NOX, ROS, Erk1/2, and p38 MAPK are involved in IL-1beta-induced IL-8 expression.	Reactive Oxygen Species	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
27393034-11	2016	CORM-2 pretreatment significantly mitigated IL-1beta-induced activation of ROS/NF-kB and Erk1/2/AP-1 cascades, blocking IL-8 expression and thus significantly reducing endothelial cell proliferation in the tumor microenvironment.	Reactive Oxygen Species	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
26347463-7	2016	CONCLUSION: Higher intakes of total cholesterol and saturated FA seem to correlate with increased serum IL8 levels, being a possible mechanism by which this pro-atherogenic intake pattern may increase the risk of age-related chronic diseases with important inflammatory contribution.	Cholesterol	36-47	C-X-C motif chemokine ligand 8	Homo sapiens	104-107
27622485-0	2016	Dendritic cells generated in the presence of vitamin D3 and stimulated with lipopolysaccharide secrete IL-8, IL-1beta, IL-10 and induce relatively low levels of CD4+CD25hiFoxp3+ T cells.	Cholecalciferol	45-55	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
26574643-0	2016	Theophylline Represses IL-8 Secretion from Airway Smooth Muscle Cells Independently of Phosphodiesterase Inhibition.	Theophylline	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
26574643-8	2016	However, theophylline (at 10 muM) was antiinflammatory and repressed secretion of the neutrophil chemoattractant cytokine IL-8, which is produced in response to TNF-alpha.	Theophylline	9-21	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
26342602-13	2016	In HSC-2 cells, Glandosane  significantly increased CXCL8 expression.	Glandosane	16-26	C-X-C motif chemokine ligand 8	Homo sapiens	52-57
27056727-9	2016	Hydrocortisone significantly attenuated IL-1beta-induced inflammatory responses in the immature human gut when administered at the time of the proinflammatory insult: IL-1beta-induced IL-8 and IL-6 secretion in the fetal ileum as well as H4 cells were significantly reduced.	Hydrocortisone	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
27056727-10	2016	Hydrocortisone also inhibited IL-8 secretion in response to TNF-alpha.	Hydrocortisone	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
26894321-7	2016	KEY RESULTS: Sulindac inhibited the transcriptional activity of NF-kappaB and decreased IL-8 transcription and secretion in TNF-alpha stimulated CF cells via a cyclooxygenase-independent mechanism.	Sulindac	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
26993523-3	2016	A preconditioning of 18% CS also increased in a time-dependent fashion the release of soluble ICAM1 (sICAM1) and IL-8.	Cesium	25-27	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
27473957-7	2016	Our results indicated that the isoquercitrin treatment of PMACI-stimulated KU812 cells significantly reduced the production of histamine and the pro-inflammatory cytokines, such as interleukin (IL)-6, IL-8, IL-1beta, and tumor necrosis factor (TNF)-alpha.	isoquercitrin	31-44	C-X-C motif chemokine ligand 8	Homo sapiens	201-205
27473957-7	2016	Our results indicated that the isoquercitrin treatment of PMACI-stimulated KU812 cells significantly reduced the production of histamine and the pro-inflammatory cytokines, such as interleukin (IL)-6, IL-8, IL-1beta, and tumor necrosis factor (TNF)-alpha.	pmaci	58-63	C-X-C motif chemokine ligand 8	Homo sapiens	201-205
26970827-6	2016	We could show that more cells adhered to CXCL8 adsorbed to hydrophobic octadecanethiol than on CXCL8 covalently bound to amino undecanethiol or CXCL8 specifically bound to immobilized heparin on aminothiol.	n-octadecyl mercaptan	71-86	C-X-C motif chemokine ligand 8	Homo sapiens	41-46
26342602-16	2016	Epithelial cells have a differential response to artificial saliva with Glandosane  changing CXCL8 expression.	Glandosane	72-82	C-X-C motif chemokine ligand 8	Homo sapiens	93-98
26970827-6	2016	We could show that more cells adhered to CXCL8 adsorbed to hydrophobic octadecanethiol than on CXCL8 covalently bound to amino undecanethiol or CXCL8 specifically bound to immobilized heparin on aminothiol.	amino undecanethiol	121-140	C-X-C motif chemokine ligand 8	Homo sapiens	41-46
27072015-6	2016	Shikonin prevented IL-1beta- or tumor necrosis factor (TNF)-alpha-mediated IL-6, IL-8, and CCL20 production in HPDLC.	shikonin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
26970827-6	2016	We could show that more cells adhered to CXCL8 adsorbed to hydrophobic octadecanethiol than on CXCL8 covalently bound to amino undecanethiol or CXCL8 specifically bound to immobilized heparin on aminothiol.	amino undecanethiol	121-140	C-X-C motif chemokine ligand 8	Homo sapiens	95-100
26970827-6	2016	We could show that more cells adhered to CXCL8 adsorbed to hydrophobic octadecanethiol than on CXCL8 covalently bound to amino undecanethiol or CXCL8 specifically bound to immobilized heparin on aminothiol.	amino undecanethiol	121-140	C-X-C motif chemokine ligand 8	Homo sapiens	95-100
26970827-6	2016	We could show that more cells adhered to CXCL8 adsorbed to hydrophobic octadecanethiol than on CXCL8 covalently bound to amino undecanethiol or CXCL8 specifically bound to immobilized heparin on aminothiol.	Heparin	184-191	C-X-C motif chemokine ligand 8	Homo sapiens	41-46
26970827-6	2016	We could show that more cells adhered to CXCL8 adsorbed to hydrophobic octadecanethiol than on CXCL8 covalently bound to amino undecanethiol or CXCL8 specifically bound to immobilized heparin on aminothiol.	Heparin	184-191	C-X-C motif chemokine ligand 8	Homo sapiens	95-100
26970827-6	2016	We could show that more cells adhered to CXCL8 adsorbed to hydrophobic octadecanethiol than on CXCL8 covalently bound to amino undecanethiol or CXCL8 specifically bound to immobilized heparin on aminothiol.	Heparin	184-191	C-X-C motif chemokine ligand 8	Homo sapiens	95-100
26970827-6	2016	We could show that more cells adhered to CXCL8 adsorbed to hydrophobic octadecanethiol than on CXCL8 covalently bound to amino undecanethiol or CXCL8 specifically bound to immobilized heparin on aminothiol.	Aminothiol	195-205	C-X-C motif chemokine ligand 8	Homo sapiens	41-46
26970827-6	2016	We could show that more cells adhered to CXCL8 adsorbed to hydrophobic octadecanethiol than on CXCL8 covalently bound to amino undecanethiol or CXCL8 specifically bound to immobilized heparin on aminothiol.	Aminothiol	195-205	C-X-C motif chemokine ligand 8	Homo sapiens	95-100
26970827-6	2016	We could show that more cells adhered to CXCL8 adsorbed to hydrophobic octadecanethiol than on CXCL8 covalently bound to amino undecanethiol or CXCL8 specifically bound to immobilized heparin on aminothiol.	Aminothiol	195-205	C-X-C motif chemokine ligand 8	Homo sapiens	95-100
27170049-10	2016	Orbital fibroblasts expressed HRH1 and loratadine and SC-514 both blocked histamine-induced IL-6, IL-8 and CCL2 production by orbital fibroblasts.	SC 514	54-60	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
27170049-10	2016	Orbital fibroblasts expressed HRH1 and loratadine and SC-514 both blocked histamine-induced IL-6, IL-8 and CCL2 production by orbital fibroblasts.	Histamine	74-83	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
27016717-0	2016	Oleic acid, hydroxytyrosol and n-3 fatty acids collectively modulate colitis through reduction of oxidative stress and IL-8 synthesis; in vitro and in vivo studies.	Oleic Acid	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
27016717-0	2016	Oleic acid, hydroxytyrosol and n-3 fatty acids collectively modulate colitis through reduction of oxidative stress and IL-8 synthesis; in vitro and in vivo studies.	3,4-dihydroxyphenylethanol	12-26	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
27016717-0	2016	Oleic acid, hydroxytyrosol and n-3 fatty acids collectively modulate colitis through reduction of oxidative stress and IL-8 synthesis; in vitro and in vivo studies.	Fatty Acids, Omega-3	31-46	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
27016717-3	2016	Caco-2 cells grown in medium chain fatty acids enriched medium has exaggerated t-butyl hydroperoxide induced cell damage, GSH depletion, and IL-1beta induced IL-8 synthesis, compared to the cells grown in oleic acid &amp; hydroxytyrosol (OT) enriched medium.	chain fatty acids	29-46	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
27016717-4	2016	Further, combined treatment of cells with eicosapentaenoic acid, docosahexaenoic acid, and OT has remarkably attenuated the cell damage, and IL-8 synthesis, compared to individual treatments.	Eicosapentaenoic Acid	42-63	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
27016717-4	2016	Further, combined treatment of cells with eicosapentaenoic acid, docosahexaenoic acid, and OT has remarkably attenuated the cell damage, and IL-8 synthesis, compared to individual treatments.	Docosahexaenoic Acids	65-85	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
27170049-9	2016	Histamine stimulated the production of IL-6, IL-8 and CCL2 by orbital fibroblasts, while it had no effect on the production of CCL5, CCL7, CXCL10, CXCL11 and hyaluronan.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
27170049-10	2016	Orbital fibroblasts expressed HRH1 and loratadine and SC-514 both blocked histamine-induced IL-6, IL-8 and CCL2 production by orbital fibroblasts.	Loratadine	39-49	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
26644386-11	2016	The production of TNF-alpha, IL-1beta, and IL-8 by monocytes from PBC patients after stimulation with lipopolysaccharide and lipoteichoic acid was significantly increased when TIPE2 was knocked down.	lipoteichoic acid	125-142	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
27035829-11	2016	RESULTS: In vitro studies showed that 1,25(OH)2D3 significantly reduced IL-1beta- or TNF-alpha-induced inflammatory responses, such as IL-8 expression and prostaglandin activity.	Calcitriol	38-49	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
26641976-18	2016	No significant change was observed in the IL-8 profile in tryptophan-treated U251 cells except that L-kynurenine at 10 microg/mL produced significantly high level of an inflammatory cytokine IL-8.	Kynurenine	100-112	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
27038552-7	2016	Antagomir-mediated inactivation of miR-424-5p prevented the IL-8-induced cell migration and invasion, indicating that miR-424-5p is required for IL-8-induced cellular invasiveness.	-424-5p	38-45	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
26701134-9	2016	In vitro culture with supernatants from cortisol-treated peripheral blood monocyte-derived macrophages resulted in altered endometrial endothelial cell expression of the angiogenic genes, CXCL2, CXCL8, CTGF, and VEGFC These data highlight the importance of local cortisol in regulating paracrine actions of macrophages in the endometrium.	Hydrocortisone	40-48	C-X-C motif chemokine ligand 8	Homo sapiens	195-200
26944408-14	2016	Finally, aloin pretreatment also inhibited saliva-induced IL-8 production.	alloin	9-14	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
26944408-15	2016	CONCLUSIONS: Results indicated that IL-1beta in saliva stimulates epithelial cells to produce IL-8 and that aloin effectively inhibits salivary IL-1beta-induced IL-8 production by mitigating the p38 and ERK pathway.	alloin	108-113	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
27145239-10	2016	LCFA (oleic acid) up-regulated tumor necrosis fator-alpha, monocyte chemoattractant-1 and interleukin-1beta while down-regulated IL-6 and IL-8 secretion to a higher extent than MCFA in mRNA and protein levels.	lcfa	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
27145239-10	2016	LCFA (oleic acid) up-regulated tumor necrosis fator-alpha, monocyte chemoattractant-1 and interleukin-1beta while down-regulated IL-6 and IL-8 secretion to a higher extent than MCFA in mRNA and protein levels.	Oleic Acid	6-16	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
26823290-8	2016	After 24 h pre-treatment with 5 muM laquinimod, manHD monocytes released lower levels of IL-1beta, IL-5, IL-8, IL-10, IL-13 and TNFalpha in response to stimulation.	5 mum laquinimod	30-46	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
26944408-0	2016	Aloin Inhibits Interleukin (IL)-1beta-Stimulated IL-8 Production in KB Cells.	alloin	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
26944408-2	2016	This study investigates stimulatory effects of salivary IL-1beta in IL-8 production and determines if aloin inhibits IL-1beta-stimulated IL-8 production in epithelial cells.	alloin	102-107	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
26944408-8	2016	KB cells were pretreated with aloin, and its effect on IL-1beta-induced IL-8 production was examined by ELISA and Western blot analysis.	alloin	30-35	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
26944408-13	2016	Aloin pretreatment inhibited IL-1beta-induced IL-8 production in a dose-dependent manner and inhibited activation of the p38 and ERK signaling pathway.	alloin	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
27038552-7	2016	Antagomir-mediated inactivation of miR-424-5p prevented the IL-8-induced cell migration and invasion, indicating that miR-424-5p is required for IL-8-induced cellular invasiveness.	-424-5p	38-45	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
27188901-10	2016	In addition, HMB supplementation was likely (78%-87% likelihood) to reduce interferon-gamma, interleukin 8, CX3CL1, and increase muscle volume for the adductor magnus (77% likelihood) compared to PL.	beta-hydroxyisovaleric acid	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	93-106
27131284-9	2016	However, dabigatran at low concentrations (3-300nM) increased significantly the expression levels of CXCL1, CXCL2, IL-8, ELAM-1, MCP-1, and tissue factor.	Dabigatran	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
27262815-7	2016	Moreover, PFKFB3 modulated toll like receptor 4 (TLR4) and MyD88 expression as well as interleukin (IL)-6 and IL-8 release from breast cancer cells in response to paclitaxel exposure.	Paclitaxel	163-173	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
27262815-9	2016	The enhanced lactate contributed to TLR4 signaling activation, IL-6 and IL-8 generation, and cell viability promotion in MCF-7 cells.	Lactic Acid	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
27229886-7	2016	In immortalized human airway smooth muscle (ASM) cells, Sul-121 dose-dependently prevented cigarette smoke extract-induced IL-8 release parallel with inhibition of nuclear translocation of the NF-kappaB subunit, p65 (each ~90%).	Sulfisoxazole	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
27223137-3	2016	The amount of F and TMP released were directly related to NaF and TMP concentrations in the varnishes.	trimetaphosphoric acid	20-23	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
27162363-4	2016	Using an in vitro model of colonic epithelial cells challenged with Escherichia coli K12, we showed that inhibition of histone deacetylases (HDAC) by trichostatin A dramatically enhanced induction of HBD2 expression, without affecting expression of IL-8.	trichostatin A	150-164	C-X-C motif chemokine ligand 8	Homo sapiens	249-253
27223137-5	2016	However, the simultaneous addition of NaF and TMP to varnishes significantly reduced the amount of F and TMP released from the products.	trimetaphosphoric acid	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
27274225-2	2016	In primary bronchial epithelial cells, exposure of toll-like receptor (TLR) ligands or tumor necrosis factor-alpha (TNF-alpha) increased TLR2 mRNA expression and reduced interleukin-8 (IL-8) release when coincubated with glucocorticosteroids.	glucocorticosteroids	221-241	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
26926379-2	2016	Study shows that NaF:Mg,Cu,P phosphor possess good OSL properties having sensitivity comparable to that of commercially available Al2O3:C (Landauer Inc.).	Magnesium	21-23	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
27146088-4	2016	Flagellin-induced interaction between the COOH region of Nox4 and the TIR domain of TLR5 led to H2O2 generation, which in turn promoted the secretion of pro-inflammatory cytokines including IL-8, as well as the expression of ICAM-1 in human aortic endothelial cells (HAECs).	Hydrogen Peroxide	96-100	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
27140710-6	2016	Tumor necrosis factor alpha, IL-6 and IL-8 levels on the fourth day after treatment showed significant decrease in the somatostatin + ulinastatin, the somatostatin + gabexate and the somatostatin + ulinastatin + gabexate subgroups compared with the somatostatin subgroup.	Gabexate	166-174	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
26926379-1	2016	OSL in doped NaF is studied.	osl	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
26926379-2	2016	Study shows that NaF:Mg,Cu,P phosphor possess good OSL properties having sensitivity comparable to that of commercially available Al2O3:C (Landauer Inc.).	p phosphor	27-37	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
26926379-2	2016	Study shows that NaF:Mg,Cu,P phosphor possess good OSL properties having sensitivity comparable to that of commercially available Al2O3:C (Landauer Inc.).	osl	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
27383709-5	2016	RESULTS: Budlein A inhibited MPO activity, IL-6, CXCL8, IL-10, and IL-12 production and induces neutrophil apoptosis.	budlein A	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	49-54
26960744-7	2016	Along with the lower levels of inflammatory cytokine gene expressions in the extract, treatment of the 2D IHOKs with Zn(2+) alone and treatment of the 3D IHOKs with Zn(2+) plus eugenol resulted in significantly lower expression levels of IL-1beta, IL-6, and IL-8 (P&lt;0.05).	Zinc	117-119	C-X-C motif chemokine ligand 8	Homo sapiens	258-262
26960744-7	2016	Along with the lower levels of inflammatory cytokine gene expressions in the extract, treatment of the 2D IHOKs with Zn(2+) alone and treatment of the 3D IHOKs with Zn(2+) plus eugenol resulted in significantly lower expression levels of IL-1beta, IL-6, and IL-8 (P&lt;0.05).	Zinc	165-167	C-X-C motif chemokine ligand 8	Homo sapiens	258-262
26960744-7	2016	Along with the lower levels of inflammatory cytokine gene expressions in the extract, treatment of the 2D IHOKs with Zn(2+) alone and treatment of the 3D IHOKs with Zn(2+) plus eugenol resulted in significantly lower expression levels of IL-1beta, IL-6, and IL-8 (P&lt;0.05).	Eugenol	177-184	C-X-C motif chemokine ligand 8	Homo sapiens	258-262
27269887-12	2016	Corticosteroids such as fluticasone propionate and dexamethasone, but not salmeterol, partially suppressed the IL-17A and TNF-alpha-induced IL-8 production.	Fluticasone	24-46	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
27269887-12	2016	Corticosteroids such as fluticasone propionate and dexamethasone, but not salmeterol, partially suppressed the IL-17A and TNF-alpha-induced IL-8 production.	Dexamethasone	51-64	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
26400651-6	2016	Chelation of Zn(2+) by the membrane permeable chelator N,N,N",N"-tetrakis-(2-pyridylmethyl)-ethylenediamine (TPEN) reduced granulocyte migration toward N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLF) and IL-8, indicating a role of free intracellular Zn(2+) in chemotaxis.	Zinc	13-15	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
26400651-6	2016	Chelation of Zn(2+) by the membrane permeable chelator N,N,N",N"-tetrakis-(2-pyridylmethyl)-ethylenediamine (TPEN) reduced granulocyte migration toward N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLF) and IL-8, indicating a role of free intracellular Zn(2+) in chemotaxis.	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	55-107	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
26400651-6	2016	Chelation of Zn(2+) by the membrane permeable chelator N,N,N",N"-tetrakis-(2-pyridylmethyl)-ethylenediamine (TPEN) reduced granulocyte migration toward N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLF) and IL-8, indicating a role of free intracellular Zn(2+) in chemotaxis.	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	109-113	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
26400651-10	2016	TPEN inhibited the lipopolysaccharide-induced secretion of chemotactic IL-8 and also anti-inflammatory IL-1ra.	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
26647918-7	2016	In sharp contrast, dexamethasone left the local release of acute-phase mediators in the lungs virtually unchanged: bronchoalveolar lavage levels of IL-6 were only 18% lower and levels of IL-8 were even higher with dexamethasone compared with placebo, although the differences between treatments were not statistically significant (P = 0.07 and P = 0.08, respectively).	Dexamethasone	214-227	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
27195204-2	2016	The present study aims to evaluate the in vivo effect of subgingivally delivered SMV gel (1.2 mg) as a local drug-delivery agent on clinical parameters and on interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) levels in gingival crevicular fluid (GCF) of chronic periodontitis patients.	Simvastatin	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
27195204-7	2016	RESULTS: SMV has an inhibitory effect on pro-inflammatory cytokines (IL-6, IL-8) and stimulatory effect on anti-inflammatory cytokines (IL-10) in GCF of periodontitis patients and has significantly positive effect on all clinical parameters except relative attachment level (RAL).	Simvastatin	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
27038884-8	2016	KEY FINDINGS: IL-8 and IL-17A levels were higher in ISS from COPD patients and HSs than from HCs.	ISS	52-55	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
26952447-4	2016	When the phosphoric acid solution contains NaF, fluorine is also incorporated into the oxide layer.	phosphoric acid	9-24	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
27038884-8	2016	KEY FINDINGS: IL-8 and IL-17A levels were higher in ISS from COPD patients and HSs than from HCs.	hepatic stimulator substance	79-82	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
27084536-0	2016	Thymoquinone inhibits growth of human medulloblastoma cells by inducing oxidative stress and caspase-dependent apoptosis while suppressing NF-kappaB signaling and IL-8 expression.	thymoquinone	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
26945908-0	2016	Suppression of IL-8-Src signalling axis by 17beta-estradiol inhibits human mesenchymal stem cells-mediated gastric cancer invasion.	Estradiol	43-59	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
26945908-11	2016	We further observed that 17beta -estradiol inhibit HBMMSCS-induced cell motility via suppressing activation of IL8-Src signalling in human gastric cancer cells.	Estradiol	25-42	C-X-C motif chemokine ligand 8	Homo sapiens	111-114
26945908-12	2016	17beta-estradiol inhibits IL8-up-regulated Src downstream target proteins including p-Cas, p-paxillin, p-ERK1/2, p-JNK1/2, MMP9, tPA and uPA.	Estradiol	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
26945908-12	2016	17beta-estradiol inhibits IL8-up-regulated Src downstream target proteins including p-Cas, p-paxillin, p-ERK1/2, p-JNK1/2, MMP9, tPA and uPA.	p-paxillin	91-101	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
26945908-12	2016	17beta-estradiol inhibits IL8-up-regulated Src downstream target proteins including p-Cas, p-paxillin, p-ERK1/2, p-JNK1/2, MMP9, tPA and uPA.	Tetradecanoylphorbol Acetate	129-132	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
26945908-13	2016	These results suggest that 17beta-estradiol significantly inhibits HBMMSCS-induced invasive motility through suppressing IL8-Src signalling axis in human gastric cancer cells.	Estradiol	27-43	C-X-C motif chemokine ligand 8	Homo sapiens	121-124
26495785-8	2016	Controlling other independent factors, the relative hazard ratio for PDAC with higher IL-8-positive TIIC levels compared with those with lower TIIC levels was 1.588 (95% confidence interval, 1.04-2.42).	pdac	69-73	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
27141896-7	2016	For an IQR increase in PM2.5, black carbon and PNC100-200, respective increases of 0.17 ng/ml (95% CI: 0.02-0.33), 0.12 ng/ml (95% CI: 0.01-0.24) and 0.13 ng/ml (95% CI:0.02-0.24) in interleukin-8 in EBC reflecting airway inflammation were also observed.	Carbon	36-42	C-X-C motif chemokine ligand 8	Homo sapiens	183-196
27134560-1	2016	Understanding the range and variability of normal, benign degenerative, and malignant (18)F sodium fluoride ((18)F NaF) positron emission tomography/computed tomography (PET/CT) uptake is important in influencing clinical interpretation.	Sodium Fluoride	92-107	C-X-C motif chemokine ligand 8	Homo sapiens	115-118
27126933-7	2016	Effect of IL-8 overexpression on proliferation, cell cycle and migration in BT549 cells was respectively investigated by MTT assay, flow cytometry and wound-healing test.	monooxyethylene trimethylolpropane tristearate	121-124	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
27128976-4	2016	18% CS increased surface expression of endothelial adhesion molecule ICAM1 and release of its soluble form (sICAM1) and inflammatory cytokine IL-8 by CS-stimulated pulmonary endothelial cells (EC).	Cesium	4-6	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
27128976-4	2016	18% CS increased surface expression of endothelial adhesion molecule ICAM1 and release of its soluble form (sICAM1) and inflammatory cytokine IL-8 by CS-stimulated pulmonary endothelial cells (EC).	Cesium	150-152	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
27128976-6	2016	Chronic exposure to 18% CS, but not to 5% CS, augmented ICAM1 and IL-8 production and EC monolayer barrier disruption induced by LPS.	Cesium	24-26	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
27173229-7	2016	In a high-glucose environment, TLR-2/4 expression was significantly upregulated in RGCs (while their viability decreased); additionally, NF-kappaB expression and secretion of TNF-alpha and IL-8 were significantly increased.	Glucose	10-17	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
27005483-7	2016	It is believed that the in situ formation of the active species of NaMgF3, NaF and Fe during the heating process could enhance the hydrogen storage properties of MgH2, due to the catalytic effects of these new species.	Hydrogen	131-139	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
27005483-7	2016	It is believed that the in situ formation of the active species of NaMgF3, NaF and Fe during the heating process could enhance the hydrogen storage properties of MgH2, due to the catalytic effects of these new species.	magnesium;hydride	162-166	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
27001463-5	2016	After treatment with nicotine (0.1-10 muM for 24 h), the HUVECs released chemotactic factors (IL-8) to attract monocytes into the tunica intima of the artery, and the monocytes then transformed into foam cells.	Nicotine	21-29	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
27175089-7	2016	However, subjects with deficient levels of vitamin D and high CRP produced significantly higher levels of the proinflammatory cytokines (TNF-alpha and IL-8) as compared to subjects with low CRP levels with nondeficient and deficient levels of vitamin D.	Vitamin D	43-52	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
26918409-1	2016	A carbonylative esterification reaction between aryl bromides and alcohols, promoted by Pd/C and NaF in the presence of oxiranes, has been developed.	aryl bromides	48-61	C-X-C motif chemokine ligand 8	Homo sapiens	91-100
26918409-1	2016	A carbonylative esterification reaction between aryl bromides and alcohols, promoted by Pd/C and NaF in the presence of oxiranes, has been developed.	Alcohols	66-74	C-X-C motif chemokine ligand 8	Homo sapiens	91-100
26918409-1	2016	A carbonylative esterification reaction between aryl bromides and alcohols, promoted by Pd/C and NaF in the presence of oxiranes, has been developed.	Palladium	88-90	C-X-C motif chemokine ligand 8	Homo sapiens	91-100
26918409-1	2016	A carbonylative esterification reaction between aryl bromides and alcohols, promoted by Pd/C and NaF in the presence of oxiranes, has been developed.	Epoxy Compounds	120-128	C-X-C motif chemokine ligand 8	Homo sapiens	91-100
27091625-5	2016	Transcriptomic profiling revealed the up-regulation of three NF-kappaB-regulated CXC-chemokines, CXCL8, CXCL1 and CXCL2, in the resistant cells that were more efficiently down-regulated after OXA + Curcumin treatment as compared to the sensitive cells.	Curcumin	198-206	C-X-C motif chemokine ligand 8	Homo sapiens	97-102
27002382-6	2016	TE and betulin treatment led to increased mRNA levels of chemokines, pro-inflammatory cytokines, and mediators important in wound healing, e.g., IL-6, TNFalpha, IL-8, and RANTES.	betulin	7-14	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
27104513-8	2016	Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p &lt; 0.05).	Gallic Acid	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	117-122
27104513-8	2016	Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p &lt; 0.05).	Gallic Acid	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	261-266
27104513-8	2016	Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p &lt; 0.05).	Chlorogenic Acid	16-32	C-X-C motif chemokine ligand 8	Homo sapiens	117-122
27104513-8	2016	Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p &lt; 0.05).	Chlorogenic Acid	16-32	C-X-C motif chemokine ligand 8	Homo sapiens	261-266
27091625-5	2016	Transcriptomic profiling revealed the up-regulation of three NF-kappaB-regulated CXC-chemokines, CXCL8, CXCL1 and CXCL2, in the resistant cells that were more efficiently down-regulated after OXA + Curcumin treatment as compared to the sensitive cells.	Oxaliplatin	192-195	C-X-C motif chemokine ligand 8	Homo sapiens	97-102
27091625-6	2016	Moreover, CXCL8 and CXCL1 gene silencing made resistant cells more sensitive to OXA through the inhibition of the Akt/NF-kappaB pathway.	Oxaliplatin	80-83	C-X-C motif chemokine ligand 8	Homo sapiens	10-15
26276563-11	2016	The results showed that the expression levels of IL-6, IL-8, TNF-alpha, and NF-kappaB which seemed to be a critical mediator in the inflammatory response tended to increase in the birds chronically treated with As2O3.	Arsenic Trioxide	211-216	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
26975834-2	2016	Here, for the first time, we show that the coupling of hydrogen adsorption and absorption could trigger giant reversible strain in bulk nanoporous Pd (np-Pd) in a weakly adsorbed NaF electrolyte.	Hydrogen	55-63	C-X-C motif chemokine ligand 8	Homo sapiens	179-182
26975834-2	2016	Here, for the first time, we show that the coupling of hydrogen adsorption and absorption could trigger giant reversible strain in bulk nanoporous Pd (np-Pd) in a weakly adsorbed NaF electrolyte.	Palladium	147-149	C-X-C motif chemokine ligand 8	Homo sapiens	179-182
26893158-7	2016	However, 1,25-dihydroxyvitamin D3 exhibited superior anti-inflammatory effects as it furthermore reduced cytokine-induced NF-kappaB nuclear translocation and interleukin-8 mRNA stability and secretion.	Calcitriol	9-33	C-X-C motif chemokine ligand 8	Homo sapiens	158-171
27069129-0	2016	Unfractionated Heparin Selectively Modulates the Expression of CXCL8, CCL2 and CCL5 in Endometrial Carcinoma Cells.	Heparin	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	63-68
27069129-5	2016	UFH attenuated the secretion of CXCL8 and CCL2, and enhanced that of CCL5.	Heparin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	32-37
27069129-7	2016	CONCLUSION: UFH has selective modulating effects on the secretion of CXCL8, CCL2 and CCL5 in different endometrial adenocarcinoma cell lines.	Heparin	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	69-74
27433050-16	2016	CONCLUSION: Subsequent to the use of NaF (0.05%) daily mouthrinse and MFP dentifrice (1000 ppm) the fluoride concentration in saliva remained elevated to a level of 0.12 ppm for mouthrinse and 0.14 ppm for dentifrice compared to baseline (0.03 ppm) up to 20 hrs postuse.	Fluorides	100-108	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
26774572-5	2016	In addition, the anti-inflammatory properties of the modified Co-Cr surfaces were assessed by measuring IL-8 and IL-6 expression levels in human endothelial cell cultures.	co-cr	62-67	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
26774572-7	2016	Interestingly, ASP- and PROP-containing substrates not only showed reduced adhesion of platelets and delayed coagulation time, but also drastically reduced the expression level of IL-8 and IL-6.	Aspirin	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
26774572-7	2016	Interestingly, ASP- and PROP-containing substrates not only showed reduced adhesion of platelets and delayed coagulation time, but also drastically reduced the expression level of IL-8 and IL-6.	Propolis	24-28	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
26934431-4	2016	CuONPs treatment caused a significant increase in IL-6 and IL-8 mRNA expression and protein levels in H292 cells in a concentration-dependent manner.	cuonps	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
26071024-8	2016	In addition, adenosine-uridine-rich elements (AREs) of the CXCL8/IL-8 3"-untranslated region (3"-UTR) reduce CXCL8/IL-8 mRNA stability.	adenosine-uridine	13-30	C-X-C motif chemokine ligand 8	Homo sapiens	59-64
26071024-8	2016	In addition, adenosine-uridine-rich elements (AREs) of the CXCL8/IL-8 3"-untranslated region (3"-UTR) reduce CXCL8/IL-8 mRNA stability.	adenosine-uridine	13-30	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
26071024-8	2016	In addition, adenosine-uridine-rich elements (AREs) of the CXCL8/IL-8 3"-untranslated region (3"-UTR) reduce CXCL8/IL-8 mRNA stability.	adenosine-uridine	13-30	C-X-C motif chemokine ligand 8	Homo sapiens	109-114
26071024-8	2016	In addition, adenosine-uridine-rich elements (AREs) of the CXCL8/IL-8 3"-untranslated region (3"-UTR) reduce CXCL8/IL-8 mRNA stability.	adenosine-uridine	13-30	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
27135904-7	2016	Oral lansoprazole therapy decreased the frequency of acute exacerbation of COPD by alleviating gastroesophageal reflux and lowering the levels of IL-1beta, IL-6, IL-8, TNF-alpha and GM-CSF in the sputum.	Lansoprazole	5-17	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
26658749-10	2016	Treatment of HUVECs with citral significantly inhibited TNF-alpha and IL-8 expression induced by LPS.	citral	25-31	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
26921254-4	2016	Additionally,L-cys suppressed the LPS-induced intestinal inflammation and oxidative stress, as demonstrated by down-regulated TNF-alpha, IL-6 and IL-8 mRNA levels, increased catalase, superoxide dismutase, glutathione peroxidase activity, glutathione (GSH) contents and the ratio of GSH and oxidized glutathione in jejunum and ileum.	Cysteine	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
26418512-2	2016	Nicotine is the most extensively investigated component of cigarette smoke, and a comprehensive analysis of the genes induced by nicotine stimulation revealed that interleukin-8 (IL-8) was induced in oral squamous cell carcinoma cell (OSCC).	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	164-177
26179980-5	2016	The results showed that exposure of monocytes to non-toxic doses of U-PM alone caused generation of reactive oxygen species (ROS), increased phosphorylation of p38, and activation of monocytes which was reflected by up-regulation of MMP-2, MMP-9 and proinflammatory cytokines IL-1beta and IL-8 expression and increased activity of pro-MMP-2 and pro-MMP-9.	u-pm	68-72	C-X-C motif chemokine ligand 8	Homo sapiens	289-293
26418512-0	2016	Nicotine-Mediated Ca(2+)-Influx Induces IL-8 Secretion in Oral Squamous Cell Carcinoma Cell.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
26914908-14	2016	Nine women (60%) had L. crispatus detected post-DMPA, which significantly correlated with reduced IL-6 (P &lt; 0.01) and IL-8 (P = 0.02).	Medroxyprogesterone Acetate	48-52	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
26825457-5	2016	AZO significantly reduced TSLP levels as well as interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-alpha without inducing cytotoxicity.	anthrone	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
26825457-6	2016	Furthermore, AZO more effectively reduced TSLP, IL-6, IL-8, and TNF-alpha levels than ZO-NP.	anthrone	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
26418512-2	2016	Nicotine is the most extensively investigated component of cigarette smoke, and a comprehensive analysis of the genes induced by nicotine stimulation revealed that interleukin-8 (IL-8) was induced in oral squamous cell carcinoma cell (OSCC).	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
26418512-2	2016	Nicotine is the most extensively investigated component of cigarette smoke, and a comprehensive analysis of the genes induced by nicotine stimulation revealed that interleukin-8 (IL-8) was induced in oral squamous cell carcinoma cell (OSCC).	Nicotine	129-137	C-X-C motif chemokine ligand 8	Homo sapiens	164-177
26418512-2	2016	Nicotine is the most extensively investigated component of cigarette smoke, and a comprehensive analysis of the genes induced by nicotine stimulation revealed that interleukin-8 (IL-8) was induced in oral squamous cell carcinoma cell (OSCC).	Nicotine	129-137	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
26418512-3	2016	Based on this background, the signaling mechanisms of nicotine-mediated IL-8 induction in OSCC was investigated.	Nicotine	54-62	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
26418512-4	2016	Augmented IL-8 secretion by Ca9-22 cells was blocked by the NF-kappaB inhibitor L-1-4"-tosylamino-phenylethyl-chloromethyl ketone (TPCK) and the nicotinic acetylcholine receptor (nAChR)-specific inhibitor alpha-bungarotoxin (alphaBtx).	Tosylphenylalanyl Chloromethyl Ketone	131-135	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
26418512-6	2016	Only the CaMK II inhibitor was found to exert an inhibitory effect on nicotine-mediated IL-8 secretion.	Nicotine	70-78	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
26418512-7	2016	Pre-treatment of the Ca9-22 cells with the Ca(2+) chelator BAPTA-AM drastically inhibited IL-8 secretion.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	59-67	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
26418512-11	2016	Nicotine-mediated IL-8 induction should be a trigger for the initiation of various diseases.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
26332444-8	2016	NODs agonist, Tri-DAP and MDP, led to the production of IL-8 and MAPK activation.	L-Ala-gamma-D-Glu-meso-diaminopimelic acid	14-21	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
26332444-8	2016	NODs agonist, Tri-DAP and MDP, led to the production of IL-8 and MAPK activation.	Acetylmuramyl-Alanyl-Isoglutamine	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
26687822-10	2016	Blocking of ERK, SAPK/JNK, and p38 MAPK inhibited the CTS-induced stimulation of COX-2 and IL-8, while IL-6 expression was mediated only by SAPK/JNK and p38 MAPK.	castanospermine	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
26780941-0	2016	MEK activity controls IL-8 expression in tamoxifen-resistant MCF-7 breast cancer cells.	Tamoxifen	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
26780941-2	2016	In the present study, we investigated the possibility that interleukin-8 (IL-8) is a prognostic marker for tamoxifen resistance and aimed to clarify the regulation of IL-8 expression in tamoxifen-resistant cells.	Tamoxifen	107-116	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
26780941-2	2016	In the present study, we investigated the possibility that interleukin-8 (IL-8) is a prognostic marker for tamoxifen resistance and aimed to clarify the regulation of IL-8 expression in tamoxifen-resistant cells.	Tamoxifen	186-195	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
26780941-4	2016	In addition, the levels of IL-8 mRNA and protein expression were significantly increased in tamoxifen-resistant (TamR) cells compared to tamoxifen-sensitive (TamS) cells.	Tamoxifen	92-101	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
26780941-4	2016	In addition, the levels of IL-8 mRNA and protein expression were significantly increased in tamoxifen-resistant (TamR) cells compared to tamoxifen-sensitive (TamS) cells.	tamr	113-117	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
26780941-4	2016	In addition, the levels of IL-8 mRNA and protein expression were significantly increased in tamoxifen-resistant (TamR) cells compared to tamoxifen-sensitive (TamS) cells.	Tamoxifen	137-146	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
26780941-4	2016	In addition, the levels of IL-8 mRNA and protein expression were significantly increased in tamoxifen-resistant (TamR) cells compared to tamoxifen-sensitive (TamS) cells.	tams	158-162	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
26537370-8	2016	RESULTS: High glucose levels inhibited PDLSC proliferation and differentiation into osteoblasts but induced NF-kappaB activation and subsequent interleukin (IL)-6 and IL-8 expression.	Glucose	14-21	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
26975648-5	2016	Furthermore, methylglyoxal induced carbonyl stress promotes the expression of the pro-inflammatory interleukins IL-6 and IL-8.	Pyruvaldehyde	13-26	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
26990318-8	2016	At 90 min, the nVNS group had a greater percent decrease in IL-8 concentration (p &lt; 0.05) compared to SST group.	nvns	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
26780941-7	2016	On the contrary, we observed that elevated IL-8 mRNA expression was suppressed by a specific MEK1/2 inhibitor, UO126, but not by the specific PI-3K inhibitor LY294002, in TamR cells, whereas, we found that overexpression of constitutively active-MEK (CA-MEK) significantly increased the levels of IL-8 mRNA expression in TamS cells.	U 0126	111-116	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
26811545-9	2016	Concordantly, the ERK inhibitor U0126 significantly decreased IL1B-induced IL6, CXCL8, CCL2 and PTGS2 mRNA abundance; IL6, CXCL8, CCL2 and PGF2 alpha release; and NF-kappaB activation.	U 0126	32-37	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
26780941-9	2016	Taken together, our results demonstrate that IL-8 expression is regulated through a MEK/ERK-dependent pathway in TamR cells, suggesting that IL-8 and its receptors may be promising therapeutic targets for overcoming tamoxifen resistance.	Tamoxifen	216-225	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
26780941-9	2016	Taken together, our results demonstrate that IL-8 expression is regulated through a MEK/ERK-dependent pathway in TamR cells, suggesting that IL-8 and its receptors may be promising therapeutic targets for overcoming tamoxifen resistance.	Tamoxifen	216-225	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
26504904-6	2016	Patients who had higher levels of IL-1beta and IL-8 were more responsive to topical sulfasalazine therapy.	Sulfasalazine	84-97	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
26504904-8	2016	Furthermore, high concentrations of IL-1beta and IL-8 in the saliva are useful indicators for the application of topical sulfasalazine in OLP patients refractory to steroid treatment.	Sulfasalazine	121-134	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
26811545-9	2016	Concordantly, the ERK inhibitor U0126 significantly decreased IL1B-induced IL6, CXCL8, CCL2 and PTGS2 mRNA abundance; IL6, CXCL8, CCL2 and PGF2 alpha release; and NF-kappaB activation.	U 0126	32-37	C-X-C motif chemokine ligand 8	Homo sapiens	123-128
26503211-8	2016	Multivariate Cox regression analysis identified IL-8 as an independent adverse prognostic factor of CSS (P &lt; 0.001) and RFS (P &lt; 0.001), which could be incorporated into the traditional TNM staging system to improve the prognostic value for CSS and RFS in ccRCC patients.	thiocysteine	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
26537583-6	2016	We observed that elevated IL-8 mRNA expression and protein secretion were suppressed by a specific MEK1/2 inhibitor, UO126.	U 0126	117-122	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
26503211-8	2016	Multivariate Cox regression analysis identified IL-8 as an independent adverse prognostic factor of CSS (P &lt; 0.001) and RFS (P &lt; 0.001), which could be incorporated into the traditional TNM staging system to improve the prognostic value for CSS and RFS in ccRCC patients.	thiocysteine	247-250	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
26503211-10	2016	Increased expression of IL-8 is a potential independent adverse prognostic biomarker for CSS and RFS in patients with ccRCC after nephrectomy.	thiocysteine	89-92	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
27011164-7	2016	The ER stress inhibitor salubrinal repressed, but inducer tunicamycin enhanced, the production of IL-6, IL-8, MMP-8, and MMP-9 in hPDLCs.	salubrinal	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
27076279-1	2016	A sensitive and convenient electrochemical method was developed for the determination of rhodamine B by a silica-pillared zirconium phosphate/nafion composite (SPZP/NAF) modified glassy carbon electrode.	rhodamine B	89-100	C-X-C motif chemokine ligand 8	Homo sapiens	165-168
27076279-1	2016	A sensitive and convenient electrochemical method was developed for the determination of rhodamine B by a silica-pillared zirconium phosphate/nafion composite (SPZP/NAF) modified glassy carbon electrode.	Silicon Dioxide	106-112	C-X-C motif chemokine ligand 8	Homo sapiens	165-168
27076279-3	2016	Because of the layer structure and large specific surface area of SPZP, the SPZP/NAF modified glassy carbon electrode showed high electrocatalytic activity toward the oxidation of rhodamine B.	spzp	66-70	C-X-C motif chemokine ligand 8	Homo sapiens	76-84
27076279-3	2016	Because of the layer structure and large specific surface area of SPZP, the SPZP/NAF modified glassy carbon electrode showed high electrocatalytic activity toward the oxidation of rhodamine B.	Carbon	101-107	C-X-C motif chemokine ligand 8	Homo sapiens	76-84
27076279-3	2016	Because of the layer structure and large specific surface area of SPZP, the SPZP/NAF modified glassy carbon electrode showed high electrocatalytic activity toward the oxidation of rhodamine B.	rhodamine B	180-191	C-X-C motif chemokine ligand 8	Homo sapiens	76-84
27076279-4	2016	Under optimal experimental conditions, the SPZP/NAF modified electrode exhibited a wide linear response to rhodamine B ranging from 0.01 to 5.0 muM and a low detection limit down to 4.3 nM (S/N = 3).	spzp	43-47	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
27076279-4	2016	Under optimal experimental conditions, the SPZP/NAF modified electrode exhibited a wide linear response to rhodamine B ranging from 0.01 to 5.0 muM and a low detection limit down to 4.3 nM (S/N = 3).	rhodamine B	107-118	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
26956674-7	2016	RESULTS: ASM cell migration toward CSE-stimulated A549 cells was markedly reduced by Ac-RRWWCR-NH2 (IL-8 inhibitor) and SB431542 (TGF-beta1 inhibitor).	antileukinate	85-98	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
26803523-7	2016	The results showed that acanthoic acid dose-dependently inhibited LPS-induced TNF-alpha and IL-8 production.	acanthoic acid	24-38	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
25589513-10	2016	RESULTS: Butyrate decreased C16.0+MSU-induced production of IL-1beta, IL-6, IL-8 and IL-1beta mRNA in PBMCs from healthy donors.	Butyrates	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
26695197-9	2016	The decrease in glucose observed for serum and NaF/KOx tubes was clinically significant at all specified time points while the bias for Glucomedics tubes did not exceed the criteria even with a centrifugation delay of 180 min.	Glucose	16-23	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
26803523-8	2016	Acanthoic acid also inhibited TNF-alpha-induced IL-8 and IL-6 production.	acanthoic acid	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
28390210-7	2016	The reference toothpaste contained 927 ppm fluoride as NaF in a conventional amorphous silica abrasive base.	Fluorides	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
26370214-8	2016	MWCNTs-COOH induced interleukin-6 (IL-6) and IL-8 release in A549 cells whereas p-MWCNTs induced IL-8 release in BEAS-2B cells.	Carbonic Acid	7-11	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
26609182-5	2016	We previously developed a (99m)Tc-labeled CXCL8 preparation in preclinical models including colitis and clinical studies.	Technetium	31-33	C-X-C motif chemokine ligand 8	Homo sapiens	42-47
26908203-0	2016	Induction of IL-8(CXCL8) and MCP-1(CCL2) with oxidative stress and its inhibition with N-acetyl cysteine (NAC) in cell culture model using HK-2 cell.	Acetylcysteine	87-104	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
26706024-6	2016	Glutamine supplementation significantly (P &lt; 0.05) attenuated the release of IL-10 at 4 h and IL-8 at 24 h, compared with conditions without glutamine.	Glutamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
26786756-9	2016	CONCLUSIONS: The present study suggests that controlled exposure to Al2O3 particles at levels below PEL (TWA) induces airway inflammation in healthy humans marked by elevated neutrophils and elevated IL-8.	Aluminum Oxide	68-73	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
26926362-0	2016	Prostaglandin E2 possesses different potencies in inducing Vascular Endothelial Growth Factor and Interleukin-8 production in COPD human lung fibroblasts.	Dinoprostone	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	98-111
26926362-1	2016	We studied the role of PGE2, its biosynthetic enzymes and its receptors, in regulating the functions of lung fibroblasts through the production of Vascular Endothelial Growth Factor (VEGF) and Interleukin-8 (IL-8) in COPD subjects.	Dinoprostone	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	193-206
26926362-1	2016	We studied the role of PGE2, its biosynthetic enzymes and its receptors, in regulating the functions of lung fibroblasts through the production of Vascular Endothelial Growth Factor (VEGF) and Interleukin-8 (IL-8) in COPD subjects.	Dinoprostone	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
26926362-6	2016	Low concentrations of synthetic PGE2 increased the release of VEGF in HFL-1, but higher concentrations were needed to induce the release of IL-8.	Dinoprostone	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
26926362-8	2016	In the airways of COPD subjects, fibroblast-derived PGE2 may regulate angiogenesis and inflammation through the production of VEGF and IL-8 respectively, suggesting that the increase in expression of COX-2, EP2 and EP4 observed in COPD fibroblasts may contribute to steering the role of PGE2 from homeostatic to pro-inflammatory.	Dinoprostone	52-56	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
24193047-4	2016	Therefore, in this study, we investigated the effects of sodium fluoride (NaF) and/or lead acetate (PbAc) on development of apoptosis, cell vitality, and proliferation in the liver cell line HepG2.	Sodium Fluoride	57-72	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
24193047-6	2016	Incubation of the hepatocytes with NaF or PbAc increased apoptosis, more when fluoride and Pb were used simultaneously.	Fluorides	78-86	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
26908203-0	2016	Induction of IL-8(CXCL8) and MCP-1(CCL2) with oxidative stress and its inhibition with N-acetyl cysteine (NAC) in cell culture model using HK-2 cell.	Acetylcysteine	106-109	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
26908203-9	2016	Exposure to hydrogen peroxide induced a significant increase in the activity of the antioxidant enzyme glutathione peroxidase and the levels of the chemokines Interleukin-8 (IL-8; CXCL8) and MCP-1 (CCL2).	Hydrogen Peroxide	12-29	C-X-C motif chemokine ligand 8	Homo sapiens	159-172
26908203-9	2016	Exposure to hydrogen peroxide induced a significant increase in the activity of the antioxidant enzyme glutathione peroxidase and the levels of the chemokines Interleukin-8 (IL-8; CXCL8) and MCP-1 (CCL2).	Hydrogen Peroxide	12-29	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
26908203-9	2016	Exposure to hydrogen peroxide induced a significant increase in the activity of the antioxidant enzyme glutathione peroxidase and the levels of the chemokines Interleukin-8 (IL-8; CXCL8) and MCP-1 (CCL2).	Hydrogen Peroxide	12-29	C-X-C motif chemokine ligand 8	Homo sapiens	180-185
26908203-11	2016	The cytokine Interleukin-1beta (IL-1beta) at 1 ng/ml significantly potentiated the expression of both IL-8 (CXCL8) and MCP-1 (CCL2) which showed synergistic response in the presence of hydrogen peroxide.	Hydrogen Peroxide	185-202	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
26908203-11	2016	The cytokine Interleukin-1beta (IL-1beta) at 1 ng/ml significantly potentiated the expression of both IL-8 (CXCL8) and MCP-1 (CCL2) which showed synergistic response in the presence of hydrogen peroxide.	Hydrogen Peroxide	185-202	C-X-C motif chemokine ligand 8	Homo sapiens	108-113
26908203-12	2016	Pre-incubation of the cells with the anti-oxidant N-acetyl cysteine (NAC) strongly suppressed the induction of both IL-8 and MCP-1 when stimulated with hydrogen peroxide and IL-1beta.	Acetylcysteine	50-67	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
26908203-12	2016	Pre-incubation of the cells with the anti-oxidant N-acetyl cysteine (NAC) strongly suppressed the induction of both IL-8 and MCP-1 when stimulated with hydrogen peroxide and IL-1beta.	Acetylcysteine	69-72	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
26908203-12	2016	Pre-incubation of the cells with the anti-oxidant N-acetyl cysteine (NAC) strongly suppressed the induction of both IL-8 and MCP-1 when stimulated with hydrogen peroxide and IL-1beta.	Hydrogen Peroxide	152-169	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
26840091-7	2016	This study shows that a monoclonal anti-TLR4 antibody inhibited cobalt-mediated increases in pro-inflammatory IL8, CCL20 and IL1A expression, as well as IL-8 secretion.	Cobalt	64-70	C-X-C motif chemokine ligand 8	Homo sapiens	110-113
27212782-2	2016	It has been recently shown that active microcalcification in the coronary arteries, one of the features that characterizes vulnerable plaques at risk of rupture, can be imaged using cardiac gated 18F-sodium fluoride (18F-NaF) PET.	18f-sodium fluoride	196-215	C-X-C motif chemokine ligand 8	Homo sapiens	221-224
26721883-7	2016	One domain, consisting of N-loop and C-helical residues (defined as alpha-domain) has also been identified previously as the GAG-binding domain for the related chemokine CXCL8/IL-8.	Glycosaminoglycans	125-128	C-X-C motif chemokine ligand 8	Homo sapiens	170-175
26721883-7	2016	One domain, consisting of N-loop and C-helical residues (defined as alpha-domain) has also been identified previously as the GAG-binding domain for the related chemokine CXCL8/IL-8.	Glycosaminoglycans	125-128	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
26846189-2	2016	Here, we successfully demonstrate the novel use of zinc oxide nanorods (ZnO NRs) in the ultrasensitive and quantitative detection of two acute kidney injury (AKI)-related protein biomarkers, tumor necrosis factor (TNF)-alpha and interleukin (IL)-8, directly from patient samples.	Zinc Oxide	51-61	C-X-C motif chemokine ligand 8	Homo sapiens	229-247
26846189-2	2016	Here, we successfully demonstrate the novel use of zinc oxide nanorods (ZnO NRs) in the ultrasensitive and quantitative detection of two acute kidney injury (AKI)-related protein biomarkers, tumor necrosis factor (TNF)-alpha and interleukin (IL)-8, directly from patient samples.	Zinc Oxide	72-75	C-X-C motif chemokine ligand 8	Homo sapiens	229-247
26846189-3	2016	We first validate the ZnO NRs-based IL-8 results via comparison with those obtained from using a conventional enzyme-linked immunosorbent method in samples from 38 individuals.	Zinc Oxide	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
26719146-8	2016	Stimulation of BEAS-2B cells with supernatant of CS-induced necrotic cells induced a significant increase in the release of CXCL8 and IL-6, in a myeloid differentiation primary response gene 88-dependent fashion.	Cesium	49-51	C-X-C motif chemokine ligand 8	Homo sapiens	124-129
26857501-7	2016	In high, non-toxic concentrations all transition metals except Cr induced IL-8 and IL-6 production in microglia, with Ni and Co providing the strongest stimulation.	Chromium	63-65	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
26857501-8	2016	When using near-physiological doses (up to 10x the normal plasma concentration), only Zn and Cu induced significant IL-8 production.	Zinc	86-88	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
26857501-8	2016	When using near-physiological doses (up to 10x the normal plasma concentration), only Zn and Cu induced significant IL-8 production.	Copper	93-95	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
26611525-9	2016	Aspect of patients, 0.45% NaCl group and 0.9% NaCl+ambroxol group were significantly different in the levels of SP-A, IL-6, IL-8 and TNF-alpha (P&lt;0.01).	Sodium Chloride	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
26611525-9	2016	Aspect of patients, 0.45% NaCl group and 0.9% NaCl+ambroxol group were significantly different in the levels of SP-A, IL-6, IL-8 and TNF-alpha (P&lt;0.01).	Sodium Chloride	46-50	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
26848751-9	2016	These results show that EGCG suppresses the IL-1beta-induced expression of IL-8 through inhibition of the NF-kappaB, p38, and ERK pathways.	epigallocatechin gallate	24-28	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
26848751-0	2016	The Effect of (-)-Epigallocatechin-3-Gallate on IL-1beta Induced IL-8 Expression in Orbital Fibroblast from Patients with Thyroid-Associated Ophthalmopathy.	epigallocatechin gallate	14-44	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
26859301-5	2016	Both higher serum IL-8 (95% CI = 0.10,3.84) and poor sleep (95% CI = 0.03,0.28) served as significant mediators linking lower DHA:AA ratios with shorter gestation.	Docosahexaenoic Acids	126-129	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
26859301-6	2016	Further, a serial mediation model moving from the DHA:AA ratio   sleep   IL-8   length of gestation was statistically significant (95% CI = 0.02, 0.79).	Docosahexaenoic Acids	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
26861339-5	2016	In comparison, sIPNs containing 300% w/w linear polymer showed an average area reduction of ~45% when the temperature was raised from 20  C to 70  C, ~36% when immersed in 1% NaF w/w salt solution and ~10% after 30 min exposure to white light irradiation, respectively.	sipns	15-20	C-X-C motif chemokine ligand 8	Homo sapiens	175-178
26861339-5	2016	In comparison, sIPNs containing 300% w/w linear polymer showed an average area reduction of ~45% when the temperature was raised from 20  C to 70  C, ~36% when immersed in 1% NaF w/w salt solution and ~10% after 30 min exposure to white light irradiation, respectively.	Polymers	48-55	C-X-C motif chemokine ligand 8	Homo sapiens	175-178
26861339-5	2016	In comparison, sIPNs containing 300% w/w linear polymer showed an average area reduction of ~45% when the temperature was raised from 20  C to 70  C, ~36% when immersed in 1% NaF w/w salt solution and ~10% after 30 min exposure to white light irradiation, respectively.	Salts	183-187	C-X-C motif chemokine ligand 8	Homo sapiens	175-178
26848751-5	2016	Treatment with EGCG significantly reduced the level of IL-1beta-induced secretion of IL-8 and the expression of IL-8 mRNA.	epigallocatechin gallate	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
26848751-5	2016	Treatment with EGCG significantly reduced the level of IL-1beta-induced secretion of IL-8 and the expression of IL-8 mRNA.	epigallocatechin gallate	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
26870616-4	2016	Our results revealed that the wound healing induced by CXCL8 was greatly attenuated by removal of HS.	Heparitin Sulfate	98-100	C-X-C motif chemokine ligand 8	Homo sapiens	55-60
26848751-6	2016	IL-1beta-induced the degradation of IkappaBalpha, and the phosphorylation of p38 and ERK, and the IL-1beta-induced expression of IL-8 mRNA was inhibited by specific inhibitors, such as BAY-117085 for NF-kB, SB203580 for p38, and PD98059 for ERK.	BAY 11-7085	185-195	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
26848751-6	2016	IL-1beta-induced the degradation of IkappaBalpha, and the phosphorylation of p38 and ERK, and the IL-1beta-induced expression of IL-8 mRNA was inhibited by specific inhibitors, such as BAY-117085 for NF-kB, SB203580 for p38, and PD98059 for ERK.	SB 203580	207-215	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
26848751-6	2016	IL-1beta-induced the degradation of IkappaBalpha, and the phosphorylation of p38 and ERK, and the IL-1beta-induced expression of IL-8 mRNA was inhibited by specific inhibitors, such as BAY-117085 for NF-kB, SB203580 for p38, and PD98059 for ERK.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	229-236	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
26870616-0	2016	Role of heparan sulfate in mediating CXCL8-induced endothelial cell migration.	Heparitin Sulfate	8-23	C-X-C motif chemokine ligand 8	Homo sapiens	37-42
26870616-7	2016	Taken together, our results demonstrated an essential role of HS in mediating CXCL8-induced endothelial cell migration, and highlighted the biological importance of the interaction between CXCL8 and heparan sulfate in wound healing.	Heparitin Sulfate	62-64	C-X-C motif chemokine ligand 8	Homo sapiens	78-83
26870616-7	2016	Taken together, our results demonstrated an essential role of HS in mediating CXCL8-induced endothelial cell migration, and highlighted the biological importance of the interaction between CXCL8 and heparan sulfate in wound healing.	Heparitin Sulfate	199-214	C-X-C motif chemokine ligand 8	Homo sapiens	78-83
26615574-0	2016	Farrerol inhibits IL-6 and IL-8 production in LPS-stimulated human gingival fibroblasts by suppressing PI3K/AKT/NF-kappaB signaling pathway.	farrerol	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
26615574-2	2016	In the present study, we investigated the anti-inflammatory effects of farrerol on the production of IL-6 and IL-8 in human gingival fibroblasts (HGFs) treated with lipopolysaccharide (LPS).	farrerol	71-79	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
26615574-6	2016	RESULTS: These results showed that farrerol inhibited LPS-induced IL-6 and IL-8 production in a dose dependent manner.	farrerol	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
26603163-10	2016	The Interleukin 8-251A &gt; T SNP was significantly correlated with an increased tumor (p = 0.048), PTE (p = 0.033) and necrosis volume (p = 0.028).	pte	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	4-17
26615574-9	2016	CONCLUSION: These results indicated that farrerol attenuated IL-6 and IL-8 production by inhibition of PI3K and AKT phosphorylation, resulting in an inhibition of NF-kappaB activation.	farrerol	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
26136303-15	2016	The replacement of NaF/KOx with Glucomedics tubes substantially impacts glucose results, giving marked rise in diabetes prevalence.	Glucose	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
26387832-5	2016	Our results were analogous to previous reports in that Meth up-regulates TNF-alpha and IL-8 after two hours of exposure.	Methamphetamine	55-59	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
26677054-8	2016	Treating A549 cells with either EtOH or EtP significantly reduced the IL-1beta- or TNF-induced IL-8 release, whereas treating Huh7 cells did not significantly alter IL-6 release.	Ethanol	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
26677054-8	2016	Treating A549 cells with either EtOH or EtP significantly reduced the IL-1beta- or TNF-induced IL-8 release, whereas treating Huh7 cells did not significantly alter IL-6 release.	ethyl pyruvate	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
26212931-6	2016	Remarkably, reduction of DG levels using the phosphatidylcholine-specific phospholipase C inhibitor D609 inhibited the secretion of VEGF and Angiopoietin-2, but increased the secretion of interleukin-8, without affecting significantly their respective mRNA levels.	Phosphatidylcholines	45-64	C-X-C motif chemokine ligand 8	Homo sapiens	188-201
26212931-6	2016	Remarkably, reduction of DG levels using the phosphatidylcholine-specific phospholipase C inhibitor D609 inhibited the secretion of VEGF and Angiopoietin-2, but increased the secretion of interleukin-8, without affecting significantly their respective mRNA levels.	tricyclodecane-9-yl-xanthogenate	100-104	C-X-C motif chemokine ligand 8	Homo sapiens	188-201
26136303-8	2016	The regression equation obtained comparing citrate to NaF/KOx tubes was used to recalculate glucose results retrieved from the laboratory information system.	Glucose	92-99	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
26136303-9	2016	RESULTS: Glucose measured in Glucomedics was higher (9.9%; p&lt;0.001), while glucose in NaF/KOx and serum was lower compared to LiH (2.4%; p&lt;0.001 and 3.2%; p&lt;0.001, respectively).	Glucose	78-85	C-X-C motif chemokine ligand 8	Homo sapiens	89-92
26501345-8	2016	Alcohol ingestion after resistance exercise affected aspects of inflammatory capacity (IL-6 and IL-8 production).	Alcohols	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
26329367-0	2016	Veratric Acid Inhibits LPS-Induced IL-6 and IL-8 Production in Human Gingival Fibroblasts.	veratric acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
26329367-6	2016	The results showed that veratric acid inhibited LPS-induced IL-6 and IL-8 production, as well as iNOS and COX-2 expression.	veratric acid	24-37	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
26378248-8	2016	Messenger RNA and protein levels of the inflammatory marker, interleukin-8, also increased following exposure to indium release ITO.	Indium	113-119	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
25610950-5	2016	RESULTS: We found that BP IgG-induced IL-6 and IL-8 release from HaCaT cells was reduced in the presence of non-toxic doses of calcitriol.	Calcitriol	127-137	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
26893718-8	2016	Furthermore, IA (0.1-10 micromol/l) significantly inhibited PGE2 production and COX2 expression in cells with LPS-induced IL-8, in a concentration-dependent manner.	Dinoprostone	60-64	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
26701795-10	2016	GOS reduced TNF-alpha- and IL-1beta-induced inflammatory responses to 25-26% and pathogen-induced IL-8 and MCP-1 to 36-39% of positive controls (P &lt; 0.001).	D-Glucitol-1,6-bisphosphate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
26553025-10	2016	However, a trend toward decreased IL-6, IL-8, and IFN-gamma levels, and favorable clinical outcomes were present in the macrolide group.	Macrolides	120-129	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
26359174-6	2016	RESULTS: Beyond the factors included in the definition, SLE patients with MetS have a significantly higher serum level of uric acid (6.88 +- 2.20 vs 4.45 +- 1.17, p &lt; 0.001) and some inflammatory biomarkers such as homocysteine, IL-8, sICAM-1 or complement molecules.	Uric Acid	122-131	C-X-C motif chemokine ligand 8	Homo sapiens	232-236
26334623-7	2016	Upon MC-A treatment, hMSCs decreased the expression levels of various cytokines including TNF-alpha, VEGF, IL-6, IL-8 and FGF-2.	myrtucommulone A	5-9	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
26871861-9	2016	HE and MT staining showed that the cartilage defect sites of the group receiving the combination of IL-8 and BMC were regenerated with cartilage-like tissues showing chondrocyte morphology.	Helium	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
26871861-9	2016	HE and MT staining showed that the cartilage defect sites of the group receiving the combination of IL-8 and BMC were regenerated with cartilage-like tissues showing chondrocyte morphology.	Meitnerium	7-9	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
26814891-5	2016	Women using injectable DMPA had increased concentration of several soluble proteins of the innate and adaptive immune system, including IL-1alpha, IL-1beta, IL-2, MIP-1beta, IP-10, IL-8, TGF-beta, HBD4, IgA, IgG1, and IgG2.	N,N-dimethyl-4-anisidine	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
26871861-10	2016	Safranin O staining showed hyaline cartilage regeneration in the group receiving IL-8 and BMC, whereas fibrous-like tissues were formed in the other groups.	phenosafranine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
27078994-9	2016	Compared with the HSP group, levels of IL-8, TNF-alpha, and NO significantly decreased after intervention of TFB (1.0 and 0.5 mg/mL; P &lt; 0.05, P &lt; 0.01).	tfb	109-112	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
27078994-12	2016	CONCLUSION: TFB could protect vascular damage by inhibiting in vivo high expression of NF-kappaB, reducing the production of IL-8, TNF-alpha, and NO in vascular endothelial cells of HSP children patients.	tfb	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
26834946-1	2016	AIM: To investigating the relationship between thoracic and cardiac (18)F-Natrium-Fluoride (18F-NaF) uptake, as a marker of ongoing calcification and cardiovascular risk factors.	Sodium Fluoride	74-90	C-X-C motif chemokine ligand 8	Homo sapiens	96-99
26808546-10	2016	Among all patients, elevated levels of interleukin-8 (IL-8), carcinoembryonic antigen (CEA), hypoxia-inducible factor 1-alpha (HIF-1 alpha), and interleukin-6 were independently associated with lower OS, while IL-8, CEA, platelet-derived growth factor receptor alpha and mucin-1 were associated with metastatic disease.	Osmium	200-202	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
26546780-7	2016	The expression of interleukin-8 (IL-8) in HL-60 cells treated with conditioned media from HepaRG cells (HL-60/HepaRG) exhibited the highest ROC-AUC value of 0.758, followed by the expression of IL-1beta in HL-60/HepaRG (ROC-AUC: 0.726).	heparg	90-96	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
26546780-7	2016	The expression of interleukin-8 (IL-8) in HL-60 cells treated with conditioned media from HepaRG cells (HL-60/HepaRG) exhibited the highest ROC-AUC value of 0.758, followed by the expression of IL-1beta in HL-60/HepaRG (ROC-AUC: 0.726).	heparg	90-96	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
26789270-7	2016	Tbeta4 activation with a Tbeta4 peptide attenuated the H2O2-induced production of NO and PGE2 and up-regulated iNOS, COX-2, and osteoclastogenic cytokines (TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17) as well as reversed the effect on RANKL and OPG in PDLCs.	Hydrogen Peroxide	55-59	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
26949603-7	2016	RESULTS: Triptolide inhibited the zymosan-induced release of IL-6, IL-8, and MCP-1 from HCFs in a concentration- and time-dependent manner.	triptolide	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
26589477-7	2016	Interestingly, poly(I:C), but neither lipopolysaccharide nor R848, increased IL-8 and chemokine (C-C motif) ligand 5 secretion.	poly	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	77-116
26781963-7	2016	We found that accumulation of cholesterol was essential for IL-17A signaling as reduced total cholesterol levels by methyl beta cyclodextrin (MBCD), significantly decreased IL-17A induced secretion of CCL20, IL-8 and S100A7 from the keratinocytes.	Cholesterol	30-41	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
26949603-7	2016	RESULTS: Triptolide inhibited the zymosan-induced release of IL-6, IL-8, and MCP-1 from HCFs in a concentration- and time-dependent manner.	Zymosan	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
26609552-8	2016	The inhibition efficiency of sodium fluoride (NaF) also received good results in pyrophosphatase inhibitor screening research.	Sodium Fluoride	29-44	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
26762579-8	2016	Plasma concentrations of VEGFA, FLT3L, c-MET, AXL, Gas6A, bone-specific alkaline phosphatase, interleukin-8 and the hypoxia markers CA9 and clusterin significantly increased during treatment with cabozantinib irrespective of response.	cabozantinib	196-208	C-X-C motif chemokine ligand 8	Homo sapiens	94-107
26759169-8	2016	However, MSC pretreatment with cisplatin led to changes in phosphorylation profiles of many kinases and also increased secretion of IL-6 and IL-8 cytokines.	Cisplatin	31-40	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
26747811-1	2016	The ionic stochastic motions in the molten alkali halide NaF are investigated by quasielastic neutron scattering and first principles molecular dynamics simulation.	Alkalies	43-49	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
26747811-1	2016	The ionic stochastic motions in the molten alkali halide NaF are investigated by quasielastic neutron scattering and first principles molecular dynamics simulation.	halide	50-56	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
26727989-1	2016	It was the aim of this study to investigate differences in fluoride bioavailability in different oral areas after the application of amine fluoride (AmF) and sodium fluoride (NaF).	Fluorides	59-67	C-X-C motif chemokine ligand 8	Homo sapiens	175-178
26727989-1	2016	It was the aim of this study to investigate differences in fluoride bioavailability in different oral areas after the application of amine fluoride (AmF) and sodium fluoride (NaF).	Sodium Fluoride	158-173	C-X-C motif chemokine ligand 8	Homo sapiens	175-178
26727989-8	2016	In the tongue coating, fluoride concentration increased faster after NaF application than after AmF application.	Fluorides	23-31	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
26727989-9	2016	After 30 minutes, the fluoride concentration decreased and remained stable until 120 minutes after AmF application and returned to baseline after NaF application.	Fluorides	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	146-149
26987326-3	2016	The present study was performed to assess the correlation between concentrations of IL-1beta, IL-6, IL-8, and TGF-beta1 in the serum with response to clarithromycin (CAM) treatment in patients with COP.	Clarithromycin	150-164	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
26987326-9	2016	We conclude that IL-6, IL-8, and TGF-beta1 may play a role in the pathogenesis of COP, as their decreased concentrations were associated with a positive response to CAM treatment.	Clarithromycin	165-168	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
26986079-2	2016	Sodium fluoride (NaF) has previously been shown to inhibit recombinant MMP-2 and MMP-9.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
26867523-4	2016	METHODS: The in vitro effects of AG1478 treatment of cultured NCI-H292 cells on lipopolysaccharide (LPS) induced or tumor necrosis factor (TNF) alpha induced MUC5AC mucin and IL-8 secretion were evaluated.	RTKI cpd	33-39	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
27251500-5	2016	In addition, ferulic acid and kaempferol showed inhibition against interleukin-8 (IL-8) and interleukin-1beta (IL-1beta) expression while ferulic acid and caffeic acid showed comparatively higher inhibition of ED associated tumor necrosis factor-alpha (TNF-alpha) expression.	ferulic acid	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
27251500-5	2016	In addition, ferulic acid and kaempferol showed inhibition against interleukin-8 (IL-8) and interleukin-1beta (IL-1beta) expression while ferulic acid and caffeic acid showed comparatively higher inhibition of ED associated tumor necrosis factor-alpha (TNF-alpha) expression.	ferulic acid	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
27251500-5	2016	In addition, ferulic acid and kaempferol showed inhibition against interleukin-8 (IL-8) and interleukin-1beta (IL-1beta) expression while ferulic acid and caffeic acid showed comparatively higher inhibition of ED associated tumor necrosis factor-alpha (TNF-alpha) expression.	kaempferol	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
27251500-5	2016	In addition, ferulic acid and kaempferol showed inhibition against interleukin-8 (IL-8) and interleukin-1beta (IL-1beta) expression while ferulic acid and caffeic acid showed comparatively higher inhibition of ED associated tumor necrosis factor-alpha (TNF-alpha) expression.	kaempferol	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
27080946-0	2016	Tanshinone IIA Induces Heme Oxygenase 1 Expression and Inhibits Cyclic Strain-Induced Interleukin 8 Expression in Vascular Endothelial Cells.	tanshinone	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	86-99
27080946-6	2016	HO-1 silencing significantly abrogated the repressive effects of tanshinone IIA on strain-induced IL-8 expression, which suggests HO-1 has a role in mediating the effects of tanshinone IIA.	tanshinone	65-75	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
27080946-6	2016	HO-1 silencing significantly abrogated the repressive effects of tanshinone IIA on strain-induced IL-8 expression, which suggests HO-1 has a role in mediating the effects of tanshinone IIA.	tanshinone	65-79	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
27080946-7	2016	This study reports for the first time that tanshinone IIA inhibits cyclic strain-induced IL-8 expression via the induction of HO-1 in endothelial cells, providing valuable new insight into the molecular pathways that may contribute to the effects of tanshinone IIA.	tanshinone	43-53	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
27080946-7	2016	This study reports for the first time that tanshinone IIA inhibits cyclic strain-induced IL-8 expression via the induction of HO-1 in endothelial cells, providing valuable new insight into the molecular pathways that may contribute to the effects of tanshinone IIA.	tanshinone	250-260	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
26353790-10	2016	In PsA explant, tofacitinib significantly decreased spontaneous secretion of IL-6, IL-8, MCP-1, MMP9/MMP2, MMP3 (all p&lt;0.05) and decreased the MMP3/TIMP3 ratio (p&lt;0.05), with no effect observed for IP-10 or IL-10.	tofacitinib	16-27	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
27833438-0	2016	The inhibitory effect of flavonoids on interleukin-8 release by human gastric adenocarcinoma (AGS) cells infected with cag PAI (+) Helicobacter pylori.	Flavonoids	25-35	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
26982743-10	2016	Both the B2 receptor antagonist MEN16132 and TLR-2 silencing inhibited IL-6 and IL-8 secretion in human OA synoviocytes.	(4-amino-5-(4-(4-(2,4-dichloro-3-(2,4-dimethyl-8-quinolyloxymethyl)phenylsulfonamido)tetrahydro-2H-4-pyranoylcarbonyl)piperazino)-5-oxopentyl)(trimethyl)ammonium	32-40	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
27889767-8	2016	RESULTS: Upon Lipopolysaccharide (LPS)-induced inflammatory response in HUVECs, Crocetin ameliorated cell cytotoxicity, suppressed MCP-1 and IL-8 expressions through blocking NF-kappaB p65 signaling transduction.	crocetin	80-88	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
27833443-12	2016	The cutoff value for detection of inflammatory changes in the DMSA scan for IL-8 was 120 pg/mg creatinine (Cr) and 40 pg/mg Cr for TGF-beta1.	Succimer	62-66	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
27833443-12	2016	The cutoff value for detection of inflammatory changes in the DMSA scan for IL-8 was 120 pg/mg creatinine (Cr) and 40 pg/mg Cr for TGF-beta1.	Creatinine	95-105	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
27833443-12	2016	The cutoff value for detection of inflammatory changes in the DMSA scan for IL-8 was 120 pg/mg creatinine (Cr) and 40 pg/mg Cr for TGF-beta1.	Creatinine	107-109	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
26459323-4	2016	The overproduction of serum IL8 level was most significant in the CADM group with active period.	cadm	66-70	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
27156328-0	2016	Glucose Stability Study: NaF/Citrate Plasma Versus Serum.	Glucose	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
27156328-13	2016	CONCLUSIONS: Compared to the serum tube, NaF/citrate plasma tube is suitable for shipping venous whole blood samples within 10 hours at room temperature without undergoing significant glycolysis.	Citric Acid	45-52	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
26402127-5	2016	Currently, little evidence has accrued to support the superiority of 18F-fluoride (18F-NaF) PET in diagnosing osseous metastases or monitoring treatment response in breast cancer when compared with conventional imaging.	Fluoride ion f-18	69-81	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
27630735-8	2016	In vitro studies using TNF-alpha and IFN-gamma treated HaCaT cells revealed that VAL inhibited the exaggerated expression of Th2 chemokines including TARC/CCL17, MDC/CCL22, and proinflammatory chemokines such as CXCL8, GM-CSF, and I-CAM through blockade of the NF-kappaB pathway.	valencene	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	212-217
26457748-13	2016	CONCLUSION: These data point to neutrophil Toll-like receptor 9 expression in acetaminophen-induced acute liver failure being mediated both by circulating endogenous DNA as well as ammonia and interleukin-8 in a synergistic manner inducing systemic inflammation, neutrophil exhaustion, and exacerbating hepatic encephalopathy.	Acetaminophen	78-91	C-X-C motif chemokine ligand 8	Homo sapiens	193-206
27041244-3	2016	We studied the effect of rosuvastatin monotherapy or its combination at a lower dose with omega-3 polyunsaturated fatty acids (omega-3 PUFAs) in the VEGF and IL-8 plasma levels in patients with mixed dyslipidaemia.	Rosuvastatin Calcium	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
27041244-3	2016	We studied the effect of rosuvastatin monotherapy or its combination at a lower dose with omega-3 polyunsaturated fatty acids (omega-3 PUFAs) in the VEGF and IL-8 plasma levels in patients with mixed dyslipidaemia.	Fatty Acids, Omega-3	90-125	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
27041244-3	2016	We studied the effect of rosuvastatin monotherapy or its combination at a lower dose with omega-3 polyunsaturated fatty acids (omega-3 PUFAs) in the VEGF and IL-8 plasma levels in patients with mixed dyslipidaemia.	Fatty Acids, Omega-3	127-140	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
27041244-11	2016	CONCLUSIONS: We show for the first time that either rosuvastatin monotherapy or its combination at a lower dose with omega-3 PUFAs reduces IL-8 levels in mixed dyslipidaemic patients.	Rosuvastatin Calcium	52-64	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
27041244-11	2016	CONCLUSIONS: We show for the first time that either rosuvastatin monotherapy or its combination at a lower dose with omega-3 PUFAs reduces IL-8 levels in mixed dyslipidaemic patients.	Fatty Acids, Omega-3	117-124	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
25045119-0	2016	Involvement of L-type Ca2+ channel and toll-like receptor-4 in nickel-induced interleukin-8 gene expression.	Nickel	63-69	C-X-C motif chemokine ligand 8	Homo sapiens	78-91
25045119-5	2016	The underlying mechanisms of nickel-induced IL-8 were investigated.	Nickel	29-35	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
25045119-6	2016	We found that nickel induced IL-8 gene expression via the L-type Ca(2+) channel, Toll-like receptor-4 (TRL-4) and nuclear factor NF-kappaB signal transduction pathways.	Nickel	14-20	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
25045119-7	2016	Nickel activated NF-kappaB expression through extracellular signal-regulated kinase 1/2 phosphorylation and then increased IL-8 expression.	Nickel	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
25045158-8	2016	Exposure to pure canola oil (PCO) exhaust did not increase mediator production, but resulted in a significant decrease in IL-8 and RANTES in some cases.	Rapeseed Oil	17-27	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
25045158-8	2016	Exposure to pure canola oil (PCO) exhaust did not increase mediator production, but resulted in a significant decrease in IL-8 and RANTES in some cases.	PANTOTHENOYLAMINOETHENETHIOL	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
27820923-6	2016	The coexposure of 0.1 ppm NO2 and Der p 1, or 1 ppm NO2 and Der p 1 significantly increased both IL-6 and IL-8 release.	Nitrogen Dioxide	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
26602157-5	2016	Furthermore, manumycin A was found to inhibit IL-1beta, IL-6, and IL-8 production in TNF alpha stimulated THP-1 cells and peripheral blood monocytes in a dose dependent manner (0.25-1 muM of manumycin A) without affecting cell viability.	manumycin	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
26355467-11	2016	At week 14, IL-8 levels were significantly lower in the low vitamin D group compared with the normal vitamin D group (11.2 [9.1-13.8] versus 20.5 [17.9-37.2] pg/mL, P = 0.005).	Vitamin D	60-69	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
27820923-6	2016	The coexposure of 0.1 ppm NO2 and Der p 1, or 1 ppm NO2 and Der p 1 significantly increased both IL-6 and IL-8 release.	Nitrogen Dioxide	52-55	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
26530812-6	2016	LY-294002 blocked IL-8-induced p-AKT1 activation resulting in reduction of DNMT1 and increase of E-cadherin expression, whereas forced demethylation using 5-aza-2"-deoxycytidine restored E-cadherin expression.	Decitabine	155-177	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
27579328-9	2016	Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO2/FiO2 &lt;= 200 mmHg and nonsurvivors than in those with PaO2/FiO2 &gt; 200 mmHg and survivors.	pao2	71-75	C-X-C motif chemokine ligand 8	Homo sapiens	7-11
28078163-1	2016	A catalase-based (NAF/MWCNTs) nanocomposite film modified glassy carbon electrode for hydrogen peroxide (H2O2) detection was developed.	Carbon	65-71	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
28078163-1	2016	A catalase-based (NAF/MWCNTs) nanocomposite film modified glassy carbon electrode for hydrogen peroxide (H2O2) detection was developed.	Hydrogen Peroxide	86-103	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
28078163-1	2016	A catalase-based (NAF/MWCNTs) nanocomposite film modified glassy carbon electrode for hydrogen peroxide (H2O2) detection was developed.	Hydrogen Peroxide	105-109	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
28116315-0	2016	LPS Cooperates with Poly-L-Arginine to Promote IL-6 and IL-8 Release via the JNK Signaling Pathway in NCI-H292 Cells.	polyarginine	20-35	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
28116315-2	2016	Herein, we aimed to study the mechanism whereby poly-L-arginine (PLA) and lipopolysaccharide (LPS) can synergistically induce the release of interleukin-6 (IL-6) and IL-8 in NCI-H292 cells.	polyarginine	48-63	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
28116315-2	2016	Herein, we aimed to study the mechanism whereby poly-L-arginine (PLA) and lipopolysaccharide (LPS) can synergistically induce the release of interleukin-6 (IL-6) and IL-8 in NCI-H292 cells.	polyarginine	65-68	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
28116315-7	2016	The effects of SP600125, an inhibitor of the JNK pathway, on the increase of p-JNK, IL-6, and IL-8 were also studied.	pyrazolanthrone	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
27294162-7	2016	The placental extravillous layer of the MGH showed high levels of IL-4, IL-6, IL-10, IL-17, and IFN-gamma and low levels of IL-1beta and IL-8, whereas the placental villous layer contained high levels of IL-17 and IFN-gamma.	mgh	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
27579328-9	2016	Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO2/FiO2 &lt;= 200 mmHg and nonsurvivors than in those with PaO2/FiO2 &gt; 200 mmHg and survivors.	pao2	132-136	C-X-C motif chemokine ligand 8	Homo sapiens	7-11
28116315-11	2016	Furthermore, SP600125 significantly inhibited the activation of JNK signal, as well as reducing the productions of IL-6 and IL-8 in response to PLA+LPS stimulation.	pyrazolanthrone	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
27579328-9	2016	Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO2/FiO2 &lt;= 200 mmHg and nonsurvivors than in those with PaO2/FiO2 &gt; 200 mmHg and survivors.	fio2	76-80	C-X-C motif chemokine ligand 8	Homo sapiens	7-11
26507542-6	2016	Quercetin also prevented INDO-induced ICAM-1 and P-selectin expressions and the increase of myeloperoxidase activity in gastric and ileal tissues and NF-kappaB activation and IL-8 production in Caco-2 cells.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
26431069-9	2016	Administration of 10 muM PD98059 significantly decreased IL-6 levels in the AF-MPhi coculture, and decreased the levels of TNF alpha and IL-8 in both the AF-MPhi and NP-MPhi cocultures.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	25-32	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
27713770-9	2016	Discussion:Altered levels of Vit D affect the balance between LL-37, IL-8 and SAA, suggesting an association with AAU, an extra-articular manifestation of AS.	Vitamin D	29-34	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
26507542-6	2016	Quercetin also prevented INDO-induced ICAM-1 and P-selectin expressions and the increase of myeloperoxidase activity in gastric and ileal tissues and NF-kappaB activation and IL-8 production in Caco-2 cells.	Indomethacin	25-29	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
26804595-14	2016	IL-8 antagonist and other anti-inflammation drugs like macrolides antibiotics, glucocorticoid and atorvastatin might be optional to resist the liquid cavity expanding as actually occurs obvious bleeding soon.	Macrolides	55-65	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
25798666-3	2016	The exposure of human glomerulus renal endothelial cells to cadmium promotes a polarized apical secretion of IL-6 and IL-8, two pivotal proinflammatory cytokines known to play a significant role in renal inflammation.	Cadmium	60-67	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
31529920-9	2016	The content of angiotensin II and endothelin I-21 correlates with level of interleukin-6 (r=0.416 and 0.445 correspondingly) and concentration of homocysteine with content of interleukin-8 (r=0.0459).	Homocysteine	146-158	C-X-C motif chemokine ligand 8	Homo sapiens	175-188
27924706-7	2016	No significant association was found between airborne metal concentrations and biomarkers of inflammation in NALF, whereas increasing metal concentrations in NALF resulted in increased concentrations of total protein, IL-8, MMP-9, and TIMP-1.	Metals	134-139	C-X-C motif chemokine ligand 8	Homo sapiens	218-222
26804595-14	2016	IL-8 antagonist and other anti-inflammation drugs like macrolides antibiotics, glucocorticoid and atorvastatin might be optional to resist the liquid cavity expanding as actually occurs obvious bleeding soon.	Atorvastatin	98-110	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
27651560-4	2016	Differentiation (BAP) and IL-8 production remained unchanged or decreased irrespective of the coating and surface; only the serum and plasma/platelets-coated ZrO2 exhibited higher BAP and IL-8 expression.	zirconium oxide	158-162	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
27725392-5	2016	Under the gaseous phase administration, acetic acid and mixed acids caused a slight increase, decrease and increase on the interleukin-8 production, the mRNA expression of the heme oxygenase-1 (HO-1) gene and the HO-1 production, respectively, at one or more time points.	Acetic Acid	40-51	C-X-C motif chemokine ligand 8	Homo sapiens	123-136
26140472-1	2016	OBJECTIVE: To compare the findings in rheumatoid arthritis (RA)-affected joints between (18)F-fluorodeoxyglucose (FDG) and (18)F-fluoride (NaF) positron emission tomography (PET)/computed tomography (CT).	f-fluoride	127-137	C-X-C motif chemokine ligand 8	Homo sapiens	139-142
26140472-7	2016	The SUVmax of (18)F-FDG correlated with that of (18)F-NaF in individual joints (r = 0.65), though detail distribution was different between two tracers.	Fluorodeoxyglucose F18	20-23	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
26510735-10	2016	Stimulation with PAF + LPS resulted in higher IL-8 release (1959.3 +- 52.3) than control (141.2 +- 12.4), LPS (167.3 +- 65.8), or PAF (1527.2 +- 129.4) treatment (p &lt; 0.05).	Platelet Activating Factor	17-20	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
27994266-8	2016	In both RA and OA patient groups, stimulation of SAAT explants with IL-1beta (1 ng/ml/100 mg tissue) significantly up-regulated release of pro-(IL-6, IL-8, tumor necrosis factor - TNF) and anti-inflammatory (IL-10) cytokines but had no effect on the secretion of adiponectin, leptin, MIF and hepatocyte growth factor (HGF).	saat	49-53	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
26740864-8	2016	Changes in IL-8, MIP-1beta, and MCP-1 serum concentrations may be associated with efficacy of pegIFNalpha- and ribavirin-based therapies in patients coinfected by HCV and HIV.	pegifnalpha	94-105	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
26740864-8	2016	Changes in IL-8, MIP-1beta, and MCP-1 serum concentrations may be associated with efficacy of pegIFNalpha- and ribavirin-based therapies in patients coinfected by HCV and HIV.	Ribavirin	111-120	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
28654417-4	2016	PROCEDURES: In this article, bone turnover and remodeling was studied using [18F]-sodium fluoride (NaF) PET data.	Sodium Fluoride	82-97	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
27050899-0	2016	Nicorandil Inhibits Cyclic Strain-Induced Interleukin-8 Expression in Human Umbilical Vein Endothelial Cells.	Nicorandil	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	42-55
27050899-2	2016	This study examined the effect of nicorandil on cyclic strain-induced interleukin-8 (IL-8) expression in human umbilical vein endothelial cells (HUVECs).	Nicorandil	34-44	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
27050899-2	2016	This study examined the effect of nicorandil on cyclic strain-induced interleukin-8 (IL-8) expression in human umbilical vein endothelial cells (HUVECs).	Nicorandil	34-44	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
27050899-6	2016	Nicorandil (1-10 mumol/l) inhibited cyclic strain-induced IL-8 expression, whereas 5-hydroxydecanoate (100 mumol/l), a selective inhibitor of the mitoKATP channel, completely reversed the inhibitory effects of nicorandil on cyclic strain-induced IL-8 expression.	Nicorandil	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
27050899-6	2016	Nicorandil (1-10 mumol/l) inhibited cyclic strain-induced IL-8 expression, whereas 5-hydroxydecanoate (100 mumol/l), a selective inhibitor of the mitoKATP channel, completely reversed the inhibitory effects of nicorandil on cyclic strain-induced IL-8 expression.	5-hydroxydecanoic acid	83-101	C-X-C motif chemokine ligand 8	Homo sapiens	246-250
27050899-8	2016	In addition, cobalt protoporphyrin (10 mumol/l), an inducer of HO-1 expression, mimicked the effects of nicorandil and inhibited IL-8 expression under cyclic strain, whereas zinc protoporphyrin IX (10 mumol/l), an inhibitor of HO-1 expression, antagonized the effect of nicorandil.	cobaltiprotoporphyrin	13-34	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
27050899-9	2016	HO-1 silencing significantly abrogated the inhibitory effects of nicorandil on cyclic strain-induced IL-8 expression, suggesting that HO-1 plays a role in the mechanism of action of nicorandil.	Nicorandil	65-75	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
27050899-9	2016	HO-1 silencing significantly abrogated the inhibitory effects of nicorandil on cyclic strain-induced IL-8 expression, suggesting that HO-1 plays a role in the mechanism of action of nicorandil.	Nicorandil	182-192	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
27050899-10	2016	KEY MESSAGES: This study is the first to report that nicorandil inhibits cyclic strain-induced IL-8 expression through the induction of HO-1 expression in HUVECs.	Nicorandil	53-63	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
26477783-6	2016	RESULTS: LPS, fMLP, imiquimod and R848 stimulated the release of CXCL8, NE and MMP-9 whereas poly I:C selectively induced CXCL8 release only.	Poly I-C	93-101	C-X-C motif chemokine ligand 8	Homo sapiens	122-127
26202066-6	2016	In addition, the NOD2 pathway up-regulation was functional, as stimulation of PBMCs with muramyl dipeptide (MDP) induced the production of higher amounts of tumour necrosis factor (TNF)-alpha, interleukin (IL)-8, and IL-1beta compared with OA PBMCs.	Acetylmuramyl-Alanyl-Isoglutamine	89-106	C-X-C motif chemokine ligand 8	Homo sapiens	193-211
27014812-6	2016	CONCLUSION: Formaldehyde exposure can cause imbalance between Th1 and Th2 cytokines secreted by 16HBE cells, as well as increased expression of IL-8 and TNF-alpha.	Formaldehyde	12-24	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
26782552-0	2015	Sevoflurane downregulates interleukin-6 and interleukin-8 levels in patients after cardiopulmonary bypass surgery: a meta-analysis.	Sevoflurane	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	44-57
26782552-1	2015	This study aimed to investigate the effect of sevoflurane on serum levels of interleukin (IL)-6 and IL-8 in patients who underwent cardiopulmonary bypass (CPB).	Sevoflurane	46-57	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
26782552-2	2015	The strength of the association between sevoflurane treatment and serum level of IL-6 and IL-8 was determined in patients who underwent CPB by summary standard mean differences (SMDs); 95% confidence interval (CI) was used.	Sevoflurane	40-51	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
26782552-3	2015	In total, seven case-control studies showed decreased IL-6 and IL-8 levels in sevoflurane-treated patients than in controls (IL-6: SMD = 1.56, 95%CI: 0.95-2.17, P &lt; 0.001; IL-8: SMD = 1.63, 95%CI: 0.30-2.96, P &lt; 0.001, respectively).	Sevoflurane	78-89	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
26782552-3	2015	In total, seven case-control studies showed decreased IL-6 and IL-8 levels in sevoflurane-treated patients than in controls (IL-6: SMD = 1.56, 95%CI: 0.95-2.17, P &lt; 0.001; IL-8: SMD = 1.63, 95%CI: 0.30-2.96, P &lt; 0.001, respectively).	Sevoflurane	78-89	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
26782552-4	2015	Further, IL-6 and IL-8 levels were significantly higher in sevoflurane-treated patients than in sevoflurane-pretreated patients (IL-6 post vs pre: SMD = 2.17, 95%CI: 1.40-2.95, P &lt; 0.001; IL-8 post vs pre: SMD = 4.01, 95%CI: 2.80-5.21, P &lt; 0.001, respectively).	Sevoflurane	59-70	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
26782552-4	2015	Further, IL-6 and IL-8 levels were significantly higher in sevoflurane-treated patients than in sevoflurane-pretreated patients (IL-6 post vs pre: SMD = 2.17, 95%CI: 1.40-2.95, P &lt; 0.001; IL-8 post vs pre: SMD = 4.01, 95%CI: 2.80-5.21, P &lt; 0.001, respectively).	Sevoflurane	59-70	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
26782552-4	2015	Further, IL-6 and IL-8 levels were significantly higher in sevoflurane-treated patients than in sevoflurane-pretreated patients (IL-6 post vs pre: SMD = 2.17, 95%CI: 1.40-2.95, P &lt; 0.001; IL-8 post vs pre: SMD = 4.01, 95%CI: 2.80-5.21, P &lt; 0.001, respectively).	Sevoflurane	96-107	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
26782552-5	2015	CPB-stratified analysis showed significant decrease in IL-6 and IL-8 levels in sevoflurane-treated patients than in controls, irrespective of the time after CPB surgery (P &lt; 0.05).	Sevoflurane	79-90	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
26782552-6	2015	Moreover, sevoflurane-pretreated patients under the &lt;12-h subgroup showed decreased IL-6 levels (P = 0.698), while all other subgroups showed decreased IL-8 levels (P &lt; 0.05).	Sevoflurane	10-21	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
26782552-7	2015	Further, subgroup analysis by different dose of sevoflurane showed decreased IL-6 and IL-8 levels in subgroups administered with a dose of &lt;2 and &gt;= 2% sevoflurane under the case vs control and pre- vs post-treatment of sevoflurane models.	Sevoflurane	48-59	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
26782552-7	2015	Further, subgroup analysis by different dose of sevoflurane showed decreased IL-6 and IL-8 levels in subgroups administered with a dose of &lt;2 and &gt;= 2% sevoflurane under the case vs control and pre- vs post-treatment of sevoflurane models.	Sevoflurane	158-169	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
26782552-7	2015	Further, subgroup analysis by different dose of sevoflurane showed decreased IL-6 and IL-8 levels in subgroups administered with a dose of &lt;2 and &gt;= 2% sevoflurane under the case vs control and pre- vs post-treatment of sevoflurane models.	Sevoflurane	158-169	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
26782552-8	2015	Serum IL-6 and IL-8 levels were significantly lower in sevoflurane-treated patients who underwent CPB, suggesting sevoflurane pretreatment to be more beneficial than post-treatment.	Sevoflurane	55-66	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
26782552-8	2015	Serum IL-6 and IL-8 levels were significantly lower in sevoflurane-treated patients who underwent CPB, suggesting sevoflurane pretreatment to be more beneficial than post-treatment.	Sevoflurane	114-125	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
26689258-7	2015	However, when the peptides were mutated on two lysine residues (K15 and K20), the inhibition effects were greatly reduced indicating these two amino acids are key residues for the initial binding of CXCL8 to CXCR1.	Lysine	47-53	C-X-C motif chemokine ligand 8	Homo sapiens	199-204
26491069-9	2015	Finally, activation of ATM and DNA damage signaling suppress cytokine production and can abrogate the overproduction of IL-8 in ROS-deficient cells.	Reactive Oxygen Species	128-131	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
26629712-4	2015	Nucleus-independent chemical shift was employed to monitor the ionic processes of NaF aqueous electrolyte in nanopores of carbon supercapacitors.	Carbon	122-128	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
26672987-5	2015	RESULTS: Healthy individuals supplemented with omega-3 FA had differential responses in prostaglandin-endoperoxide synthase 1 (PTGS1), prostaglandin-endoperoxide synthase 2 (PTGS2), arachidonate 12-lipoxygenase (ALOX12), and interleukin 8 (IL-8) gene expression in isolated PBMCs.	Fatty Acids, Omega-3	47-57	C-X-C motif chemokine ligand 8	Homo sapiens	225-238
26674118-3	2015	Here we identify IL-8 as a hypoxia-regulated cytokine in both AML cell lines and primary AML samples that is induced within 48 hours of severe hypoxia (1% O2).	Oxygen	155-157	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
26633568-2	2015	We find a large surface band gap (E(g)(Surf), up to 2.52 eV) for a NaF/KF-postdeposition treated (PDT) absorber significantly increases compared to the CIGSe bulk band gap and to the Eg(Surf) of 1.61 eV found for an absorber treated with NaF only.	surf	39-43	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
26633568-2	2015	We find a large surface band gap (E(g)(Surf), up to 2.52 eV) for a NaF/KF-postdeposition treated (PDT) absorber significantly increases compared to the CIGSe bulk band gap and to the Eg(Surf) of 1.61 eV found for an absorber treated with NaF only.	surf	39-43	C-X-C motif chemokine ligand 8	Homo sapiens	238-241
26633568-2	2015	We find a large surface band gap (E(g)(Surf), up to 2.52 eV) for a NaF/KF-postdeposition treated (PDT) absorber significantly increases compared to the CIGSe bulk band gap and to the Eg(Surf) of 1.61 eV found for an absorber treated with NaF only.	lysylphenylalanine	71-73	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
26633568-2	2015	We find a large surface band gap (E(g)(Surf), up to 2.52 eV) for a NaF/KF-postdeposition treated (PDT) absorber significantly increases compared to the CIGSe bulk band gap and to the Eg(Surf) of 1.61 eV found for an absorber treated with NaF only.	lysylphenylalanine	71-73	C-X-C motif chemokine ligand 8	Homo sapiens	238-241
26633568-2	2015	We find a large surface band gap (E(g)(Surf), up to 2.52 eV) for a NaF/KF-postdeposition treated (PDT) absorber significantly increases compared to the CIGSe bulk band gap and to the Eg(Surf) of 1.61 eV found for an absorber treated with NaF only.	surf	186-190	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
26672987-5	2015	RESULTS: Healthy individuals supplemented with omega-3 FA had differential responses in prostaglandin-endoperoxide synthase 1 (PTGS1), prostaglandin-endoperoxide synthase 2 (PTGS2), arachidonate 12-lipoxygenase (ALOX12), and interleukin 8 (IL-8) gene expression in isolated PBMCs.	Fatty Acids, Omega-3	47-57	C-X-C motif chemokine ligand 8	Homo sapiens	240-244
26515417-7	2015	In contrast to clopidogrel, ticagrelor also significantly reduced peak levels of IL-8 and growth colony-stimulating factor and increased peak levels of the anti-inflammatory cytokine IL-10.	Ticagrelor	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
26677330-9	2015	Baseline serum levels of interleukin-6 (Z=-2.155; P=0.031) and interleukin-8 (Z=-2.616; P=0.009) were significantly higher when moderate-to-severe AEs were present (n=13 patients with moderate-to-severe AEs).	aes	147-150	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
26641100-7	2015	ANCE-induced IL-6, IL-8, and MCP-1 release was inhibited by IL-1 receptor antagonist and by an IKK2 inhibitor (a blocker of NF-kappaB signaling) in a concentration-dependent manner, but was not affected by a pan-caspase inhibitor (Z-VAD-FMK).	ance	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
26420839-9	2015	Patient hTEC produced and secreted elevated amounts of the pro-inflammatory cytokine IL8, which was highly correlated with the acridine orange staining.	Acridine Orange	127-142	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
26420839-10	2015	Summarizing, hTEC of MMAuria patients are characterized by disturbed energy metabolism and ROS production that lead to increased autophagy and IL8 secretion.	Reactive Oxygen Species	91-94	C-X-C motif chemokine ligand 8	Homo sapiens	143-146
26677330-11	2015	CONCLUSION: These results demonstrate that serum levels of interleukin-6, interleukin-8, and macrophage inflammatory protein-1beta as potential blood biomarkers could be utilized to identify the responsiveness of patients to serotonin and norepinephrine reuptake inhibitor like milnacipran, or to identify those patients who may experience AEs strong enough to warrant discontinuation of treatment.	Serotonin	225-234	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
26266556-13	2015	SCFAs induced a dose-dependent and pertussis toxin-sensitive IL-8 response in bronchial epithelial cells, with a higher production of IL-8 in CFBE41o(-) than in 16HBE14o(-) cells.	Fatty Acids, Volatile	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
26266556-13	2015	SCFAs induced a dose-dependent and pertussis toxin-sensitive IL-8 response in bronchial epithelial cells, with a higher production of IL-8 in CFBE41o(-) than in 16HBE14o(-) cells.	Fatty Acids, Volatile	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
25969431-9	2015	In human OA synovium, paquinimod blocked proinflammatory (interleukin (IL)-6, IL-8, tumour necrosis factor-alpha) and catabolic (matrix metalloproteinases 1 and 3) factors induced by S100A9 (n=5).	paquinimod	22-32	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
26163999-8	2015	In conclusion, pretreatment serum IL-8 is a useful prognostic marker for TACE refractoriness and LT-free survival in TACE-treated patients with HBV-associated HCC.	Chlorotrianisene	73-77	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
26373407-4	2015	The chloride ions can, in a third step, be exchanged with fluoride ions by immersion of the ionomer in NaF solution.	Chlorides	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
26373407-4	2015	The chloride ions can, in a third step, be exchanged with fluoride ions by immersion of the ionomer in NaF solution.	Fluorides	58-66	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
26396142-6	2015	Mechanistic studies have shown that calcitriol-active form of vitamin D-influences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kappaB pathway, and the expression of the cytokines TNFalpha, IL1beta, IL6, IL8, IL17, and TGFbeta1.	Calcitriol	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	260-263
26396142-6	2015	Mechanistic studies have shown that calcitriol-active form of vitamin D-influences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kappaB pathway, and the expression of the cytokines TNFalpha, IL1beta, IL6, IL8, IL17, and TGFbeta1.	Vitamin D	62-71	C-X-C motif chemokine ligand 8	Homo sapiens	260-263
26387812-0	2015	Association of single nucleotide polymorphisms in IL8 and IL13 with sunitinib-induced toxicity in patients with metastatic renal cell carcinoma.	Sunitinib	68-77	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
26303011-0	2015	PA401, a novel CXCL8-based biologic therapeutic with increased glycosaminoglycan binding, reduces bronchoalveolar lavage neutrophils and systemic inflammatory markers in a murine model of LPS-induced lung inflammation.	pa401	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
26303011-0	2015	PA401, a novel CXCL8-based biologic therapeutic with increased glycosaminoglycan binding, reduces bronchoalveolar lavage neutrophils and systemic inflammatory markers in a murine model of LPS-induced lung inflammation.	Glycosaminoglycans	63-80	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
26303011-3	2015	CXCL8 exerts its chemotactic activity by binding to its GPCR receptors (CXCR1/R2) located on neutrophils, as well as through interactions with glycosaminoglycans (GAGs) on cell surfaces including those of the microvascular endothelium.	Glycosaminoglycans	143-161	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
26303011-3	2015	CXCL8 exerts its chemotactic activity by binding to its GPCR receptors (CXCR1/R2) located on neutrophils, as well as through interactions with glycosaminoglycans (GAGs) on cell surfaces including those of the microvascular endothelium.	Glycosaminoglycans	163-167	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
26303011-5	2015	METHODS: We have engineered increased GAG-binding affinity into human CXCL8, thereby obtaining a competitive inhibitor that displaces wild-type IL-8/CXCL8 from GAGs.	Glycosaminoglycans	160-164	C-X-C motif chemokine ligand 8	Homo sapiens	70-75
26303011-5	2015	METHODS: We have engineered increased GAG-binding affinity into human CXCL8, thereby obtaining a competitive inhibitor that displaces wild-type IL-8/CXCL8 from GAGs.	Glycosaminoglycans	160-164	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
26303011-5	2015	METHODS: We have engineered increased GAG-binding affinity into human CXCL8, thereby obtaining a competitive inhibitor that displaces wild-type IL-8/CXCL8 from GAGs.	Glycosaminoglycans	160-164	C-X-C motif chemokine ligand 8	Homo sapiens	149-154
26387812-4	2015	METHODS: In this exploratory study, we selected SNPs in genes CYP3A4, NR1I2, POR, IL8, IL13, IL4-R, HIF1A and MET that might possibly be associated with sunitinib treatment outcome.	Sunitinib	153-162	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
26387812-10	2015	CONCLUSIONS: We show that polymorphisms in IL8 rs1126647 and IL13 rs1800925 are associated with sunitinib-induced toxicities.	Sunitinib	96-105	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
26964198-5	2015	The samples upconversion luminescent spectra showed the intensity enhancement of red and green light emission peaks with increasement of the ratio of NaF/RE3+.	re3+	154-158	C-X-C motif chemokine ligand 8	Homo sapiens	150-153
26964198-7	2015	The chromaticity coordinate diagram exhibited that the change of the luminescent color of samples could be achieved by adjusting the ratio of NaF/RE3+.	re3+	146-150	C-X-C motif chemokine ligand 8	Homo sapiens	142-145
26964198-8	2015	With the increasing of NaF/RE3+ ratio, for the whole light-emitting colors of samples, the shift from yellow region to near red region could be realized.	re3+	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
26507163-6	2015	mRNA and protein expressions of IL-1beta and IL-8 decreased significantly when pretreated HCECs with recombinant human SP-D for 4h before A. fumigatus stimulation, while IL-1beta and IL-8 increased when pretreated with SP-D antibody for 1h.	Hydrogen	237-239	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
26453510-5	2015	Levels of thymic stromal lymphopoietin, tumor necrosis factor (TNF)-alpha, IL-1beta, and IL-8 increased by IL-32 or LPS were significantly reduced by treatment with acteoside in THP-1 cells.	acteoside	165-174	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
26453510-7	2015	In IL-32-induced macrophages, acteoside significantly reduced LPS-induced TNF-alpha, IL-1beta, IL-6, and IL-8 production.	acteoside	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
26590116-6	2015	Artesunate reduced methacholine-induced airway hyper-responsiveness, suppressed pulmonary inflammation cell recruitment and IL-4, IL-8, IL-13 and TNF-alpha levels, selectively inhibited PI3Kdelta/Akt pathway, and restored HDAC2 activity.	Artesunate	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
26590116-8	2015	Glucocorticoid sensitivity was evaluated by the inhibition of TNF-alpha-induced IL-8 production by dexamethasone.	Dexamethasone	99-112	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
26613389-13	2015	Combinations of BMI &gt;= 30 with elevated IL-6, IL-8, hsCRP, TNF-alpha, and leptin predicted improved response to L-methylfolate calcium in MDD patients with an inadequate antidepressant response.	levomefolate calcium	115-137	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
25715004-5	2015	RESULTS: Latanoprost stimulated the release of IL-6, IL-8, and MCP-1 from HTFs in a concentration-dependent and time-dependent manner, whereas timolol maleate and pilocarpine had no such effects.	Latanoprost	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
26156812-5	2015	Calcitriol inhibited interleukin (IL)-6, IL-8, CC chemokine ligand (CCL) 20, CXC chemokine ligand (CXCL) 10, and matrix metalloproteinase (MMP)-3 release from IL-1beta-stimulated HPDLC.	Calcitriol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
26156812-7	2015	Moreover, we found c-jun N-terminal kinase (JNK) phosphorylation and IkappaB-alpha degradation in IL-1beta-stimulated HPDLC were inhibited by calcitriol, and JNK and nuclear factor (NF)-kappaB inhibitors could decrease IL-6, IL-8, CCL20, CXCL10, and MMP-3 productions in IL-1beta-treated HPDLC.	Calcitriol	142-152	C-X-C motif chemokine ligand 8	Homo sapiens	225-229
26507164-8	2015	We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner.	icariin	146-153	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
26507164-8	2015	We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner.	icariin	146-153	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
26454222-14	2015	In contrast, NaF reduced step height when applied after citric acid immersion, but only in the presence of saliva.	Citric Acid	56-67	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
25715004-7	2015	The latanoprost-induced release of IL-6, IL-8, and MCP-1 was attenuated by inhibitors of MAPK (PD98059, SB203580, or JNK inhibitor II) or NF-kappaB (IkappaB kinase 2 inhibitor) signaling pathways.	Latanoprost	4-15	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
26297794-8	2015	Furthermore, the selective CXC chemokine receptor 2 and formyl peptide receptor 2 antagonists, SB225002 and WRW4, respectively, blocked the synergy between IL-8/CXC chemokine ligand 8 and serum amyloid A1alpha in neutrophil chemotaxis in vitro, indicating that for synergy their corresponding G protein-coupled receptors are required.	SB 225002	95-103	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
26507164-8	2015	We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner.	icariin	14-21	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
26507164-8	2015	We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner.	icariin	14-21	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
26407807-7	2015	Activation of AMPK, using two pharmacologically distinct compounds, AICAR or phenformin, significantly suppressed LPS- or IL-1beta-induced gene expression and secretion of pro-inflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, and COX-2 and subsequent prostaglandin release from adipose tissue and skeletal muscle.	Phenformin	77-87	C-X-C motif chemokine ligand 8	Homo sapiens	219-223
25712856-6	2015	RESULTS: In HGFs, histamine induced expression of CCL20 and IL8 genes in a time-dependent manner (p &lt; 0.05).	Histamine	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
25712856-7	2015	Combined stimulation with histamine and Pam3CSK4 or LPS led to a significant amplification in expression of CCL20 and IL-8 when compared with treatment with each stimulant alone (p &lt; 0.05), and this effect was mediated via pathways involving the H1R (p &lt; 0.05).	Histamine	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
26350254-7	2015	These results were supported by experiments in the human colonic epithelial cell line Caco-2, where ALA supplementation was shown to be effective in inhibiting inflammation induced by IL-1beta by down-regulating mRNA levels of pro-inflammatory genes including IL-8, COX2 and inducible nitric oxide synthase.	alpha-Linolenic Acid	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	260-264
26334245-9	2015	Pharmacologic and siRNA-mediated inhibition of PLD1 and PLD2 attenuated the nicotine- and LPS-induced upregulation of inducible nitric oxide (NO) synthase and cyclooxygenase-2, production of NO, and prostaglandin E2, and mRNA expression and secretion of tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-8.	Nicotine	76-84	C-X-C motif chemokine ligand 8	Homo sapiens	311-315
26378490-1	2015	BACKGROUND: PET/computed tomography (CT) imaging with the sodium-(F)-fluoride/2-(F)-fluoro-2-deoxy-D-glucose (F-NaF/F-FDG) cocktail has been proposed for patients with osseous metastases.	2-(f)-fluoro-2-deoxy-d-glucose	78-108	C-X-C motif chemokine ligand 8	Homo sapiens	112-115
26378490-12	2015	When the F-NaF : F-FDG ratio changed from 1 : 8 to 1 : 2, the typical SUV on the generated PET images increased by 50%, whereas the change in the uptake visual pattern was hardly noticeable.	f-fdg	17-22	C-X-C motif chemokine ligand 8	Homo sapiens	11-14
26378490-13	2015	CONCLUSION: F-NaF and F-FDG in the cocktail contribute equally to image formation when the F-NaF : F-FDG ratio is 1 : 5.	f-fdg	22-27	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
26319029-4	2015	On the contrary, increased upregulation of CD86 and interleukin 8 (IL-8) production were observed in THP-1 cells exposed to combinations of citral (Cit) or imidazolidinyl urea (IMZ) with DBP, indicative of an adjuvant effect.	citral	140-146	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
26549126-10	2015	Treatments with IL-8, LPS, ET-1 and dexamethasone were able to increase three to fourfold Ucn1 release from cultured endothelial cells.	Dexamethasone	36-49	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
26270575-6	2015	RESULTS: DHA significantly attenuated IL-1beta induced proinflammatory IL-8 and IL-6 protein and mRNA in fetal H4, NEC-IEC, and mature Caco2, NCM460 IEC, compared to control and PAL treatment.	Docosahexaenoic Acids	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
26270575-8	2015	ARA had potent anti-inflammatory effects with lower IL-8 and IL-6 (protein and mRNA) in fetal H4 but not in NEC-IEC or adult IEC.	Arachidonic Acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
26319029-4	2015	On the contrary, increased upregulation of CD86 and interleukin 8 (IL-8) production were observed in THP-1 cells exposed to combinations of citral (Cit) or imidazolidinyl urea (IMZ) with DBP, indicative of an adjuvant effect.	citral	140-146	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
26319029-4	2015	On the contrary, increased upregulation of CD86 and interleukin 8 (IL-8) production were observed in THP-1 cells exposed to combinations of citral (Cit) or imidazolidinyl urea (IMZ) with DBP, indicative of an adjuvant effect.	citral	148-151	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
26319029-4	2015	On the contrary, increased upregulation of CD86 and interleukin 8 (IL-8) production were observed in THP-1 cells exposed to combinations of citral (Cit) or imidazolidinyl urea (IMZ) with DBP, indicative of an adjuvant effect.	citral	148-151	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
26319029-4	2015	On the contrary, increased upregulation of CD86 and interleukin 8 (IL-8) production were observed in THP-1 cells exposed to combinations of citral (Cit) or imidazolidinyl urea (IMZ) with DBP, indicative of an adjuvant effect.	imidazolidinyl urea	156-175	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
26319029-4	2015	On the contrary, increased upregulation of CD86 and interleukin 8 (IL-8) production were observed in THP-1 cells exposed to combinations of citral (Cit) or imidazolidinyl urea (IMZ) with DBP, indicative of an adjuvant effect.	imidazolidinyl urea	156-175	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
26319029-4	2015	On the contrary, increased upregulation of CD86 and interleukin 8 (IL-8) production were observed in THP-1 cells exposed to combinations of citral (Cit) or imidazolidinyl urea (IMZ) with DBP, indicative of an adjuvant effect.	imidazolidinyl urea	177-180	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
26319029-4	2015	On the contrary, increased upregulation of CD86 and interleukin 8 (IL-8) production were observed in THP-1 cells exposed to combinations of citral (Cit) or imidazolidinyl urea (IMZ) with DBP, indicative of an adjuvant effect.	imidazolidinyl urea	177-180	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
26463037-5	2015	Thrombin-induced IL-8/CXCL8 release was inhibited by CK2 inhibitors (apigenin and tetrabromobenzotriazole, TBB), small interfering RNA of CK2beta (CK2beta siRNA), and MSK1 siRNA.	tetrabromobenzotriazole	82-105	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
26739470-10	2015	CONCLUSION: Stimulation of hepatocytes by the PA fatty acid in vitro promotes mRNA expression of TNF-alpha, MCP-1 and IL-8, but overexpression of JAZF1 inhibits the PA-induced expression and secretion of these factors.	pa fatty acid	46-59	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
26739470-10	2015	CONCLUSION: Stimulation of hepatocytes by the PA fatty acid in vitro promotes mRNA expression of TNF-alpha, MCP-1 and IL-8, but overexpression of JAZF1 inhibits the PA-induced expression and secretion of these factors.	Palmitic Acid	46-48	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
26551350-5	2015	l-Trp treatment (5 mM) reduced TNF-alpha-induced IL-8 secretion from HT-29 or Caco-2 cells to about 50 or 40%, respectively.	Tryptophan	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
25970774-8	2015	Gemcitabine-treatment of PC cells induced expression of various growth factors/cytokines, including IL-8, which exhibited greatest upregulation.	gemcitabine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
26410779-5	2015	The analysis of pro-inflammatory cytokines release by ELISA revealed that resveratrol, lipoic acid melatonin and Co-Q10 inhibited the BBB endothelial release of pro-inflammatory cytokines IL-6 and IL-8, reduced (not Co-Q10) CSE-induced up-regulation of Platelet Cell Adhesion Molecule-1 (PECAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1) &amp; E-selectin and inhibited monocytes-endothelial cell adhesion.	Resveratrol	74-85	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
26410779-5	2015	The analysis of pro-inflammatory cytokines release by ELISA revealed that resveratrol, lipoic acid melatonin and Co-Q10 inhibited the BBB endothelial release of pro-inflammatory cytokines IL-6 and IL-8, reduced (not Co-Q10) CSE-induced up-regulation of Platelet Cell Adhesion Molecule-1 (PECAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1) &amp; E-selectin and inhibited monocytes-endothelial cell adhesion.	lipoic acid melatonin	87-108	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
26410779-5	2015	The analysis of pro-inflammatory cytokines release by ELISA revealed that resveratrol, lipoic acid melatonin and Co-Q10 inhibited the BBB endothelial release of pro-inflammatory cytokines IL-6 and IL-8, reduced (not Co-Q10) CSE-induced up-regulation of Platelet Cell Adhesion Molecule-1 (PECAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1) &amp; E-selectin and inhibited monocytes-endothelial cell adhesion.	coenzyme Q10	113-119	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
26572585-4	2015	EC overexpression of mutant ITGB4 with specific tyrosines mutated to phenylalanine (Y1440, Y1526 Y1640, or Y1422) resulted in significantly attenuated CS-induced cytokine expression (IL6, IL-8, MCP-1, and RANTES).	Cesium	151-153	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
26463037-5	2015	Thrombin-induced IL-8/CXCL8 release was inhibited by CK2 inhibitors (apigenin and tetrabromobenzotriazole, TBB), small interfering RNA of CK2beta (CK2beta siRNA), and MSK1 siRNA.	tetrabromobenzotriazole	82-105	C-X-C motif chemokine ligand 8	Homo sapiens	22-27
26885050-6	2015	In this study, we showed Dex inhibited the increase in cTnI and CK-MB, attenuated the production of pro-inflammatory cytokines TNF-alpha, IL-6 and IL-8, and promoted anti-inflammatory cytokine IL-10 production.	Dexmedetomidine	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
26885173-9	2015	RESULTS: Compared with those in normal glucose condition, IL-6 and IL-8 expression were increased in high glucose condition.	Glucose	39-46	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
26463037-5	2015	Thrombin-induced IL-8/CXCL8 release was inhibited by CK2 inhibitors (apigenin and tetrabromobenzotriazole, TBB), small interfering RNA of CK2beta (CK2beta siRNA), and MSK1 siRNA.	2-ethylhexyl 2,3,4,5-tetrabromobenzoate	107-110	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
26885173-9	2015	RESULTS: Compared with those in normal glucose condition, IL-6 and IL-8 expression were increased in high glucose condition.	Glucose	106-113	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
26463037-5	2015	Thrombin-induced IL-8/CXCL8 release was inhibited by CK2 inhibitors (apigenin and tetrabromobenzotriazole, TBB), small interfering RNA of CK2beta (CK2beta siRNA), and MSK1 siRNA.	2-ethylhexyl 2,3,4,5-tetrabromobenzoate	107-110	C-X-C motif chemokine ligand 8	Homo sapiens	22-27
29124230-14	2015	In addition, SB203580 (p38 inhibitor) and U0126 (ERK1/2 inhibitor) significantly suppressed the expression of TNF-alpha and IL-8 in LPS-stimulated THP-1 cells.	SB 203580	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
26573531-5	2015	Immediately after treatment with poly(I:C), PHF11, IL8, and interferon-dependent ISG15 RNA expression was increased.	poly	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
26553339-5	2015	In hypoxia and serum-deprived culture conditions, LPA induces CD34(+) cell proliferation without maintaining the their undifferentiating state, and enhances IL-8, IL-6 and G-CSF secretion during the first 12 h compared to non-treated cells.	lysophosphatidic acid	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
29124230-14	2015	In addition, SB203580 (p38 inhibitor) and U0126 (ERK1/2 inhibitor) significantly suppressed the expression of TNF-alpha and IL-8 in LPS-stimulated THP-1 cells.	U 0126	42-47	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
26614998-10	2015	The propofol could inhibit the expression of IL-6, IL-8 and TNF-alpha caused by LPS.	Propofol	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
26531309-9	2015	However, PSA-TMC-ODN and PSA-TMC-ODN-MTX resulted in significant decreases in the inflammatory mediators IL-6 and IL-8 in both cell models.	tmc-odn	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
26531309-9	2015	However, PSA-TMC-ODN and PSA-TMC-ODN-MTX resulted in significant decreases in the inflammatory mediators IL-6 and IL-8 in both cell models.	psa-tmc-odn-mtx	25-40	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
26296578-8	2015	Resveratrol exerted a high, dose-dependent, antiviral activity against HRV-16 replication and reduced virus-induced secretion of IL-6, IL-8 and RANTES to levels similar to that of uninfected nasal epithelia.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
25847254-3	2015	We found that 10-MDP caused the release of inflammatory cytokines including NO, PGE2, iNOS, COX-2, TNF-alpha, IL-1beta, IL-6 and IL-8 in a concentration-dependent manner.	methacryloyloxydecyl dihydrogen phosphate	14-20	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
26614998-11	2015	After the intervention treatment of 50 mug/mL propofol, the concentration of IL-6, IL-8 and TNF-alpha was significantly decreased (P &lt; 0.01).	Propofol	46-54	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
26535082-6	2015	PKC inhibitors, MAPK inhibitors, and ROS quenchers also significantly attenuated expression of CXCL8.	ros	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	95-100
26354876-8	2015	This compound behaves like the prototypic AhR ligand 6-formylindolo[3,2-b]carbazole, a cutaneous UV light-induced tryptophan metabolite, both promoting IL-22, IL-8, and CCL2 secretion by T-cells and macrophages.	6-formylindolo(3,2-b)carbazole	53-83	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
25969155-6	2015	The highest %SHR and the lowest DeltaKHN were seen for the 5% NaF/5% TMP varnish, followed by 5% NaF and placebo.	trimetaphosphoric acid	69-72	C-X-C motif chemokine ligand 8	Homo sapiens	62-65
25969155-7	2015	CONCLUSION: The remineralizing effect of a 5% NaF varnish is significantly enhanced when associated with TMP.	trimetaphosphoric acid	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
26133785-2	2015	The dysfunctional effect of CFTR mutations, principally the F508del-CFTR mutant, is further manifested by hypersecretion of the pro-inflammatory chemokine interleukin-8 into the airway lumen, which further contributes to morbidity and mortality.	f508del	60-67	C-X-C motif chemokine ligand 8	Homo sapiens	155-168
26386353-9	2015	Similarly, pretreatment with FeSO4 stimulated H2O2-induced TRPM2 activation at 37 C in U937 cells and enhanced H2O2-induced ERK phosphorylation and interleukin-8 (CXCL8) production.	ferrous sulfate	29-34	C-X-C motif chemokine ligand 8	Homo sapiens	148-161
26386353-9	2015	Similarly, pretreatment with FeSO4 stimulated H2O2-induced TRPM2 activation at 37 C in U937 cells and enhanced H2O2-induced ERK phosphorylation and interleukin-8 (CXCL8) production.	ferrous sulfate	29-34	C-X-C motif chemokine ligand 8	Homo sapiens	163-168
26386353-0	2015	Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe(2+) in human monocytic U937 cells.	Hydrogen Peroxide	17-21	C-X-C motif chemokine ligand 8	Homo sapiens	62-75
26386353-0	2015	Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe(2+) in human monocytic U937 cells.	Hydrogen Peroxide	17-21	C-X-C motif chemokine ligand 8	Homo sapiens	77-82
26386353-0	2015	Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe(2+) in human monocytic U937 cells.	ammonium ferrous sulfate	112-118	C-X-C motif chemokine ligand 8	Homo sapiens	62-75
26386353-0	2015	Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe(2+) in human monocytic U937 cells.	ammonium ferrous sulfate	112-118	C-X-C motif chemokine ligand 8	Homo sapiens	77-82
26386353-9	2015	Similarly, pretreatment with FeSO4 stimulated H2O2-induced TRPM2 activation at 37 C in U937 cells and enhanced H2O2-induced ERK phosphorylation and interleukin-8 (CXCL8) production.	Hydrogen Peroxide	46-50	C-X-C motif chemokine ligand 8	Homo sapiens	163-168
26386353-9	2015	Similarly, pretreatment with FeSO4 stimulated H2O2-induced TRPM2 activation at 37 C in U937 cells and enhanced H2O2-induced ERK phosphorylation and interleukin-8 (CXCL8) production.	Hydrogen Peroxide	111-115	C-X-C motif chemokine ligand 8	Homo sapiens	148-161
26386353-9	2015	Similarly, pretreatment with FeSO4 stimulated H2O2-induced TRPM2 activation at 37 C in U937 cells and enhanced H2O2-induced ERK phosphorylation and interleukin-8 (CXCL8) production.	Hydrogen Peroxide	111-115	C-X-C motif chemokine ligand 8	Homo sapiens	163-168
26386353-10	2015	Although the addition of H2O2 to cells under conditions of intracellular Fe(2+)-accumulation caused cell death, concentration of H2O2 required for CXCL8 production was lower than that resulting in cell death.	Hydrogen Peroxide	129-133	C-X-C motif chemokine ligand 8	Homo sapiens	147-152
26386353-11	2015	These results indicate that intracellular Fe(2+)-accumulation sensitizes TRPM2 channels to H2O2 and subsequently produces CXCL8 at around body temperature.	ammonium ferrous sulfate	42-48	C-X-C motif chemokine ligand 8	Homo sapiens	122-127
25919965-5	2015	VEGF regulated other important angiogenic proteins including PAI-1 and IL-8 in response to bleomycin exposure.	Bleomycin	91-100	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
26669014-15	2015	Raised levels of IL8 titers were also found in all 11 DHF patients.	dhf	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
26669014-18	2015	Prediction efficacy of IL8, CIC and cryoglobulin for DHF was determined using the receiver operator characteristic curve (ROC).	dhf	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
25820539-8	2015	MACs caused an increase in vessel formation in in vivo models through the production of IL-8.	macs	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
26505478-11	2015	IL-17A promoted stabilization of CXCL8 mRNA in BEAS-2B cells treated with poly(I:C).	poly	74-78	C-X-C motif chemokine ligand 8	Homo sapiens	33-38
26395911-10	2015	RESULTS: In monolayer cultures of DPCs, L-MIM at nontoxic concentrations increased the production of VEGF and IL-8 in the presence of AGEs.	Mimosine	40-45	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
26172313-6	2015	NO-np significantly suppressed IL-1beta, tumor necrosis factor-alpha (TNF-alpha), IL-8, and IL-6 from human monocytes, and IL-8 and IL-6 from human keratinocytes, respectively.	Neptunium	3-5	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
26172313-6	2015	NO-np significantly suppressed IL-1beta, tumor necrosis factor-alpha (TNF-alpha), IL-8, and IL-6 from human monocytes, and IL-8 and IL-6 from human keratinocytes, respectively.	Neptunium	3-5	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
26252749-8	2015	At specific times during healing, the azithromycin group exhibited significantly lower levels of interleukin (IL)-6 and IL-8 in GCF than the amoxicillin group and exhibited significantly lower levels of granulocyte colony stimulating factor, IL-8, macrophage inflammatory protein-1beta, and interferon-gamma-inducible protein-10 in PICF.	Azithromycin	38-50	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
26252749-8	2015	At specific times during healing, the azithromycin group exhibited significantly lower levels of interleukin (IL)-6 and IL-8 in GCF than the amoxicillin group and exhibited significantly lower levels of granulocyte colony stimulating factor, IL-8, macrophage inflammatory protein-1beta, and interferon-gamma-inducible protein-10 in PICF.	Azithromycin	38-50	C-X-C motif chemokine ligand 8	Homo sapiens	242-246
26520736-3	2015	The authors aim to quantify and reduce the bias introduced by MRACnobone in the standard uptake value (SUV) of spinal and pelvic lesions in 20 PET/MRI examinations with [18F]NaF.	mracnobone	62-72	C-X-C motif chemokine ligand 8	Homo sapiens	174-177
26520736-15	2015	The analysis of the 20 [18F]NaF PET/MRI examinations revealed relative SUVmax differences between PETnobone and PETbone of (-8.8%+-2.7%, p=0.01) and (-8.1%+-1.9%, p=2.4x10(-8)) in pelvic and spinal lesions, respectively.	petnobone	98-107	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
26099791-9	2015	Hyperosmolar HES 200/0.5 and albumin showed significantly different pattern of recovery with increased concentration of MIG, IP-10, C3a and C5a and decreased concentration of IL-1beta, TNF, MCP-1 and IL-8 in comparison with dextran 60.	Hydroxyethyl Starch Derivatives	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
26517722-8	2015	Dexamethasone suppression of the LPS-induced IL-8 mRNA production by steroid resistant asthmatics PBMC in the presence of p38 and ERK inhibitors was evaluated by real time PCR.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
26517722-8	2015	Dexamethasone suppression of the LPS-induced IL-8 mRNA production by steroid resistant asthmatics PBMC in the presence of p38 and ERK inhibitors was evaluated by real time PCR.	Steroids	69-76	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
26160865-7	2015	Overexpression of miR-17 inhibited basal and agonist-induced IL-8 protein production in F508del-CFTR homozygous CFTE29o(-) tracheal, CFBE41o(-) and/or IB3 bronchial epithelial cells.	f508del	88-95	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
26282378-0	2015	Induction of oxidative stress by Taxol  vehicle Cremophor-EL triggers production of interleukin-8 by peripheral blood mononuclear cells through the mechanism not requiring de novo synthesis of mRNA.	Paclitaxel	33-38	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
26282378-0	2015	Induction of oxidative stress by Taxol  vehicle Cremophor-EL triggers production of interleukin-8 by peripheral blood mononuclear cells through the mechanism not requiring de novo synthesis of mRNA.	cremophor EL	48-60	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
26535717-7	2015	The expression of NF-kappaBp65 and IL-8 in CSE-stimulated normal HBE cells was inhibited by 15d-PGJ2 at both the mRNA level and the protein level.	15-deoxy-delta(12,14)-prostaglandin J2	92-100	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
26517722-12	2015	P38 inhibitor significantly enhanced DEX suppression of LPS-induced IL-8 mRNA by PBMC of steroid resistant asthmatics.	Dextromethorphan	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
26517722-12	2015	P38 inhibitor significantly enhanced DEX suppression of LPS-induced IL-8 mRNA by PBMC of steroid resistant asthmatics.	Steroids	89-96	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
26543772-2	2015	This paper traces some aspects of this failure to a compensatory erlotinib-mediated increase in interleukin-8.	Erlotinib Hydrochloride	65-74	C-X-C motif chemokine ligand 8	Homo sapiens	96-109
26543772-6	2015	FINDINGS: The old sulfone antibiotic dapsone- one of the very first antibiotics in clinical use- has demonstrated several interleukin-8 system inhibiting actions.	Sulfones	18-25	C-X-C motif chemokine ligand 8	Homo sapiens	122-135
26543772-6	2015	FINDINGS: The old sulfone antibiotic dapsone- one of the very first antibiotics in clinical use- has demonstrated several interleukin-8 system inhibiting actions.	Dapsone	37-44	C-X-C motif chemokine ligand 8	Homo sapiens	122-135
26543772-8	2015	Erlotinib typically gives a rash that has recently been proven to come about via an erlotinib triggered up-regulated keratinocyte interleukin-8 synthesis.	Erlotinib Hydrochloride	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	130-143
26543772-8	2015	Erlotinib typically gives a rash that has recently been proven to come about via an erlotinib triggered up-regulated keratinocyte interleukin-8 synthesis.	Erlotinib Hydrochloride	84-93	C-X-C motif chemokine ligand 8	Homo sapiens	130-143
26267317-0	2015	The role of interleukin-8 (IL-8) and IL-8 receptors in platinum response in high grade serous ovarian carcinoma.	Platinum	55-63	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
26539118-9	2015	In addition, nuciferine decreased TNF-a, IL-6 and IL-8 as well as the siRNA PASK group.	nuciferine	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
26160521-10	2015	Furthermore, a heptane-soluble (non-polar) extract of DEP induced both IL-6 and CXCL8 release, whereas a PBS-soluble (highly polar) extract induced only IL-6.	Heptanes	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
26483408-9	2016	We show that the A subunit-dependent ERK1/2 activation is mediated through ZAK-dependent signaling, and inhibition of ERK1/2 activation via the MEK1/2 inhibitors U0126 and PD98059 results in decreased Stx1-mediated IL-8 mRNA.	U 0126	162-167	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
26483408-9	2016	We show that the A subunit-dependent ERK1/2 activation is mediated through ZAK-dependent signaling, and inhibition of ERK1/2 activation via the MEK1/2 inhibitors U0126 and PD98059 results in decreased Stx1-mediated IL-8 mRNA.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	172-179	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
26854163-2	2015	Sodium (18)F-fluoride [(18)F]-NaF PET/CT was performed prior the treatment of (223)RaCl2, after the first cycle and after the sixth cycle.	sodium (18)f-fluoride	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
26267317-3	2015	We studied the expression of IL-8 and IL-8 receptors in platinum sensitive and resistant cell lines.	Platinum	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
26267317-3	2015	We studied the expression of IL-8 and IL-8 receptors in platinum sensitive and resistant cell lines.	Platinum	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
26267317-4	2015	Using qRT-PCR and immunohistochemistry, both platinum sensitive (PEA1, PEO14) and resistant (PEA2, PEO23) show increased expression of IL-8 and IL-8 receptors.	Platinum	45-53	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
26267317-4	2015	Using qRT-PCR and immunohistochemistry, both platinum sensitive (PEA1, PEO14) and resistant (PEA2, PEO23) show increased expression of IL-8 and IL-8 receptors.	Platinum	45-53	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
26267317-6	2015	Knockdown of IL-8 increased sensitivity to cisplatin in platinum sensitive and reversed platinum resistance in resistant cell lines, decreased the expression of anti-apoptotic Bcl-2 and decreased inhibitory phosphorylation of pro-apoptotic Bad.	Cisplatin	43-52	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
26267317-6	2015	Knockdown of IL-8 increased sensitivity to cisplatin in platinum sensitive and reversed platinum resistance in resistant cell lines, decreased the expression of anti-apoptotic Bcl-2 and decreased inhibitory phosphorylation of pro-apoptotic Bad.	Platinum	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
26267317-6	2015	Knockdown of IL-8 increased sensitivity to cisplatin in platinum sensitive and reversed platinum resistance in resistant cell lines, decreased the expression of anti-apoptotic Bcl-2 and decreased inhibitory phosphorylation of pro-apoptotic Bad.	Platinum	88-96	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
26267317-7	2015	IL-8 receptor antagonist treatment also enhanced platinum sensitivity.	Platinum	49-57	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
26550541-1	2015	[(18)F] sodium fluoride (NaF) PET/CT is a current, clinically relevant method to assess bone metastases.	Sodium Fluoride	8-23	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
26267317-9	2015	Inhibition of IL-8 signalling can enhance response in platinum sensitive and resistant disease.	Platinum	54-62	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
26446923-9	2015	In comparison to the explants treated only with LPS, pre-treatment with 0.01-1.0 muM progesterone significantly blunted (73, 56, 56, 75, 25, 48 %) the secretion of TNF-alpha, IL-1beta, IL-6, IL-8, MIP-1alpha, IL-10, respectively.	Progesterone	85-97	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
26455818-6	2015	H2S donors increased glutathione and superoxide dismutase in CS exposed U937 cells and inhibited CS-induced TNF-alpha and IL-8 secretion.	Hydrogen Sulfide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
26202107-5	2015	Depot medroxyprogesterone acetate (DMPA) users had significantly higher MIP-1alpha, MIP-1beta, IL-6, IL-8, IP-10, and RANTES concentrations.	Medroxyprogesterone Acetate	6-33	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
26284488-9	2015	The search for mediators of senescent HPMC activity showed that increased SW480 cell proliferation was stimulated by IL-6, migration by CXCL8 and CCL2, invasion by IL-6, MMP-3 and uPA, and epithelial-mesenchymal transition by TGF-beta1.	Hypromellose Derivatives	38-42	C-X-C motif chemokine ligand 8	Homo sapiens	136-141
26202107-5	2015	Depot medroxyprogesterone acetate (DMPA) users had significantly higher MIP-1alpha, MIP-1beta, IL-6, IL-8, IP-10, and RANTES concentrations.	Medroxyprogesterone Acetate	35-39	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
25781052-7	2015	Data also revealed a reduction in MUC5AC, IL-6, and IL-8 expression levels in MAG-DHA-treated shCFTR cells stimulated, or not, with LPS.	dehydroacetic acid	82-85	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
26202107-6	2015	Norethisterone oenanthate users had significantly higher IL-6, IL-8, and RANTES concentrations.	norethindrone enanthate	0-25	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
26205304-1	2015	UNLABELLED: Sodium 18F-fluoride (18F-NaF) PET/CT imaging is a promising imaging technique for the assessment of atherosclerosis but is hampered by a lack of validated quantification protocols.	SODIUM FLUORIDE F-18	12-31	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
25781052-9	2015	After MAG-DHA treatments, messenger RNA transcript levels for MUC5AC, IL-6, and IL-8 were markedly reduced in LPS-treated CFTR siRNA bronchi.	docosahexaenoic acid monoacylglyceride	6-13	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
26341987-6	2015	Sputum interleukin (IL)-6 and growth-regulated oncogene (GRO)-alpha and serum GRO-alpha, IL-1ss and IL-8 levels increased with AZD5069 versus placebo (all p&lt;0.001), while serum high-sensitivity C-reactive protein levels did not change.	N-(2-(2,3-difluoro-6-benzylthio)-6-(3,4-dihydroxybutan-2-yloxy)pyrimidin-4-yl)azetidine-1-sulfonamide	127-134	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
26465888-11	2015	The expression levels of IL-6 and IL-8 were reduced when cells were seeded on graphene foam as compared to Ti and graphene film.	Graphite	78-86	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
26465888-11	2015	The expression levels of IL-6 and IL-8 were reduced when cells were seeded on graphene foam as compared to Ti and graphene film.	Graphite	114-122	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
26133961-2	2015	Ex vivo storage of PCs is associated with a storage lesion characterized by partial platelet activation and the release of soluble mediators, such as soluble CD40 ligand (sCD40L), RANTES, and interleukin (IL)-8.	pcs	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	192-210
26740893-15	2015	Levocetirizine has a better effect on decreasing the symptoms and plasmatic levels of IL-1beta and IL-8.	levocetirizine	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
26178144-0	2015	Down-regulation of IL-8 by high-dose vitamin D is specific to hyperinflammatory macrophages and involves mechanisms beyond up-regulation of DUSP1.	Vitamin D	37-46	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
26178144-2	2015	Vitamin D transcriptionally up-regulates the anti-inflammatory gene DUSP1, which partly controls production of the inflammatory chemokine IL-8.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
26178144-4	2015	We tested the ability of vitamin D metabolites to down-regulate IL-8 production in CF macrophages.	Vitamin D	25-34	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
26178144-10	2015	Vitamin D metabolites down-regulated stimulated IL-8 only in those hyperinflammatory MDM, and only when used at high doses (&gt;100 nM for 25OHD3 , or &gt;1 nM for 1,25(OH)2 D3 and paricalcitol).	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
26178144-10	2015	Vitamin D metabolites down-regulated stimulated IL-8 only in those hyperinflammatory MDM, and only when used at high doses (&gt;100 nM for 25OHD3 , or &gt;1 nM for 1,25(OH)2 D3 and paricalcitol).	paricalcitol	181-193	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
26178144-11	2015	The magnitude of IL-8 down-regulation by vitamin D metabolites or paricalcitol was moderate (~30% vs. &gt;70% by low-dose dexamethasone).	Vitamin D	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
26178144-11	2015	The magnitude of IL-8 down-regulation by vitamin D metabolites or paricalcitol was moderate (~30% vs. &gt;70% by low-dose dexamethasone).	paricalcitol	66-78	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
26178144-11	2015	The magnitude of IL-8 down-regulation by vitamin D metabolites or paricalcitol was moderate (~30% vs. &gt;70% by low-dose dexamethasone).	Dexamethasone	122-135	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
26178144-13	2015	CONCLUSIONS AND IMPLICATIONS: Vitamin D metabolites and their analogues moderately down-regulate IL-8 in hyperinflammatory macrophages, including those from CF.	Vitamin D	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
26194066-0	2015	House dust mite allergen Der f 1 induces IL-8 in human basophilic cells via ROS-ERK and p38 signal pathways.	Reactive Oxygen Species	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
26194066-6	2015	The antioxidant N-acetyl-cysteine (NAC) inhibited phosphorylation of ERK, but not p38, suggesting that secretion of IL-8 in KU812 cells treated with Der f 1 is dependent on ROS, ERK MAPK and p38 MAPK.	Acetylcysteine	16-33	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
26194066-6	2015	The antioxidant N-acetyl-cysteine (NAC) inhibited phosphorylation of ERK, but not p38, suggesting that secretion of IL-8 in KU812 cells treated with Der f 1 is dependent on ROS, ERK MAPK and p38 MAPK.	Acetylcysteine	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
25750008-11	2015	Compared with the control group, the hydrogen group had a statistically significantly lower expression of IL-1beta (P = 0.0317), IL-6 (P = 0.0159), IL-8 (P = 0.0195) and TNF-alpha (P = 0.0159).	Hydrogen	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
26360022-0	2015	Correction: ZFC3H1, a Zinc Finger Protein, Modulates IL-8 Transcription by Binding with Celastramycin A, a Potential Immune Suppressor.	celastramycin A	88-103	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
26180016-11	2015	Furthermore, IL-8 was significantly increased in IBS-D patients with a self-rating anxiety scale (SAS) or SDS score &gt;=50 (P=0.016, P=0.008, respectively) as compared with that in patients scoring &lt;50.	sds	106-109	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
26321412-0	2015	Sphingosine 1-phosphate regulates IL-8 expression and secretion via S1PR1 and S1PR2 receptors-mediated signaling in extravillous trophoblast derived HTR-8/SVneo cells.	sphingosine 1-phosphate	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
26321412-4	2015	IL-8 also promotes trophoblast cell migration and invasion, and stimulates the secretion of progesterone.	Progesterone	92-104	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
26321412-5	2015	The induction and mechanism of IL-8 secretion by EVT is still unknown.	EVT	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
26321412-8	2015	RESULTS: We found that S1P induces IL-8 gene expression and protein secretion in EVT derived HTR-8/SVneo cells but not in BeWo cells.	EVT	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
26321412-9	2015	SEW2781, the selective agonist of S1PR(1), induced IL-8 gene expression but not protein secretion.	sew2781	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
26321412-10	2015	The specific S1PR(2) inhibitor JTE-013 could drastically inhibit IL-8 secretion.	JTE 013	31-38	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
26321412-12	2015	Selective Rho-kinase inhibitor Y27632 and Rac1 inhibitor NSC23766 could block IL-8 secretion in these cells.	Y 27632	31-37	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
26418032-6	2015	Inhibition of the TLR3, TLR/TIR-domain-containing adaptor-inducing interferon beta (TRIF), NF-kappaB, and IRF3 pathways decreased the polyI:C- and IL-17A/polyI:C-induced G-CSF and IL-8 mRNA expression.	Poly I	134-139	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
26418032-6	2015	Inhibition of the TLR3, TLR/TIR-domain-containing adaptor-inducing interferon beta (TRIF), NF-kappaB, and IRF3 pathways decreased the polyI:C- and IL-17A/polyI:C-induced G-CSF and IL-8 mRNA expression.	Poly I	154-159	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
26406307-11	2015	Glutathione depletion augmented CXCL8 responses by 1.49x (CI 1.02-2.17) compared with wood smoke alone.	Glutathione	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	32-37
26397719-5	2015	T-oligos injected into the uteri of pregnant CD1 mice on day 14 of gestation, led to increased p38MAPK, SA-beta-gal (SA beta-gal) staining in murine amniotic sacs and higher AF IL-8 levels on day 18, compared to saline treated controls.	2',5'-oligoadenylate	1-8	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
26232645-10	2015	Administration of bilirubin reduced mean linear intercept and mean alveoli area, increased mean alveoli number, reduced macrophage, neutrophil and TNF-alpha content of BALF, and increased BALF and serum IL-10 level, but lowered local and systemic CCL2, CXCL2, CXCL8 and IL-17 levels.	Bilirubin	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	260-265
26134265-4	2015	Pre-treatment of TQ inhibited TNF-alpha-induced interleukin-6 (IL-6) and IL-8 production and ICAM-1, VCAM-1, and cadherin-11 (Cad-11) expression in RA-FLS (p&lt;0.01).	thymoquinone	17-19	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
26360879-6	2015	Surprisingly, co-stimulation with PAF+SAF demonstrated that SAF strongly inhibited the PAF-driven IL-8 production, showing that SAF has potent anti-inflammatory effects.	Syntex adjuvant formulation	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
26360879-6	2015	Surprisingly, co-stimulation with PAF+SAF demonstrated that SAF strongly inhibited the PAF-driven IL-8 production, showing that SAF has potent anti-inflammatory effects.	Syntex adjuvant formulation	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
26360879-6	2015	Surprisingly, co-stimulation with PAF+SAF demonstrated that SAF strongly inhibited the PAF-driven IL-8 production, showing that SAF has potent anti-inflammatory effects.	Platelet Activating Factor	87-90	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
26360879-6	2015	Surprisingly, co-stimulation with PAF+SAF demonstrated that SAF strongly inhibited the PAF-driven IL-8 production, showing that SAF has potent anti-inflammatory effects.	Syntex adjuvant formulation	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
26758116-11	2015	(3) In steroid group, IL-2 and IL-8 in BALF of patient whose fever disappeared after steroid therapy were both significantly lower than that of patients who still had fever (t=2.771, 2.054, P=0.010, 0.049) , but no significant difference was found between the two groups in BALF IL-1 beta, IL-4, IL-6, IL-10, IFN-gamma levels (P&gt;0.05).	Steroids	7-14	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
26758116-11	2015	(3) In steroid group, IL-2 and IL-8 in BALF of patient whose fever disappeared after steroid therapy were both significantly lower than that of patients who still had fever (t=2.771, 2.054, P=0.010, 0.049) , but no significant difference was found between the two groups in BALF IL-1 beta, IL-4, IL-6, IL-10, IFN-gamma levels (P&gt;0.05).	Steroids	85-92	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
26758116-13	2015	(2) Incresed BALF IL-1 beta, IL-4, IL-6, IL-8, IL-10, IFN-gamma levels were observed in RMPP and high level of BALF IL-2 and IL-8 might have some relevance with persistent fever of RMPP in children.	rmpp	88-92	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
26758116-13	2015	(2) Incresed BALF IL-1 beta, IL-4, IL-6, IL-8, IL-10, IFN-gamma levels were observed in RMPP and high level of BALF IL-2 and IL-8 might have some relevance with persistent fever of RMPP in children.	rmpp	181-185	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
26418032-3	2015	In this study, we demonstrated that IL-17A and polyI:C, the ligand of TLR3, synergistically induced the expression of proinflammatory cytokines and chemokines (G-CSF, IL-8, CXCL1, CXCL5, IL-1F9), but not type I interferon (IFN-alpha1, -beta) in primary culture of normal human bronchial epithelial cells.	Poly I-C	47-54	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
26407698-2	2015	Since SDF is not available in certain countries, some dentists use adjunctive application of 25 % silver nitrate (AgNO3) and 5 % sodium fluoride (NaF) to arrest ECC.	Sodium Fluoride	129-144	C-X-C motif chemokine ligand 8	Homo sapiens	146-149
26407698-13	2015	Lower concentrations of silver and fluoride are contained in 25 % AgNO3 and 5 % NaF, respectively, than in 38 % SDF; therefore, AgNO3/NaF are more favourable for use in young children.	Silver	24-30	C-X-C motif chemokine ligand 8	Homo sapiens	80-83
26407698-13	2015	Lower concentrations of silver and fluoride are contained in 25 % AgNO3 and 5 % NaF, respectively, than in 38 % SDF; therefore, AgNO3/NaF are more favourable for use in young children.	Silver	24-30	C-X-C motif chemokine ligand 8	Homo sapiens	134-137
26407698-13	2015	Lower concentrations of silver and fluoride are contained in 25 % AgNO3 and 5 % NaF, respectively, than in 38 % SDF; therefore, AgNO3/NaF are more favourable for use in young children.	Fluorides	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	80-83
26407698-14	2015	Because its use for caries management is painless, simple, low-cost, and approved in many countries, AgNO3/NaF could be widely recommended and promoted as an alternative treatment to conventional invasive management of ECC.	Silver Nitrate	101-106	C-X-C motif chemokine ligand 8	Homo sapiens	107-110
26234943-0	2015	Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology.	heparan sulfate dodecasaccharides	10-43	C-X-C motif chemokine ligand 8	Homo sapiens	87-92
26283481-6	2015	Using cell lines and primary airway epithelial cells (both submerged and well-differentiated), we observed that pure poly(I:C) stimulated IFN-beta mainly through the TLR3/TRIF pathway and IL-8 through an unidentified pathway.	poly	117-121	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
26283481-9	2015	In contrast, we show that stimulation of the RIG-I/MAVS pathway, such as when poly(I:C) is delivered intracellularly in a complex with liposomes or via nucleofection, selectively stimulates IFN-beta with low IL-8 costimulation.	Poly I-C	78-87	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
26360879-5	2015	Immortalised airway epithelial cells (Beas-2B) exposed to bacteria-free filtrates from PA (PAF) induced a robust production of the neutrophil chemoattractant IL-8 while bacteria-free filtrates from SA (SAF) had a minimal effect.	Platelet Activating Factor	91-94	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
26360879-5	2015	Immortalised airway epithelial cells (Beas-2B) exposed to bacteria-free filtrates from PA (PAF) induced a robust production of the neutrophil chemoattractant IL-8 while bacteria-free filtrates from SA (SAF) had a minimal effect.	Syntex adjuvant formulation	202-205	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
26360879-6	2015	Surprisingly, co-stimulation with PAF+SAF demonstrated that SAF strongly inhibited the PAF-driven IL-8 production, showing that SAF has potent anti-inflammatory effects.	Platelet Activating Factor	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
26340264-7	2015	The adipose tissue and placenta of treated women exhibited a significant decrease in TLR4 adipose and placental expression as well as IL6, IL8, and TNFalpha In vitro, EPA and DHA suppressed the activation of TLR4, IL6, IL8 induced by palmitate in culture of adipose and trophoblast cells.	Eicosapentaenoic Acid	167-170	C-X-C motif chemokine ligand 8	Homo sapiens	139-142
26252471-2	2015	Here we provide evidence that 2-electron reduction of a (formazanate)BF2 precursor leads to NaF elimination and formation of an N-heterocyclic boron carbenoid, and describe the formation of a series of unusual BN heterocycles that result from trapping of this fragment.	(formazanate)bf2	56-72	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
26333527-7	2015	IL-6, IL-8, IL-1beta and TNF-alpha concentration in NBL showed inverse correlation coefficients with the peroxidation products of fatty acids.	Fatty Acids	130-141	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
26340264-7	2015	The adipose tissue and placenta of treated women exhibited a significant decrease in TLR4 adipose and placental expression as well as IL6, IL8, and TNFalpha In vitro, EPA and DHA suppressed the activation of TLR4, IL6, IL8 induced by palmitate in culture of adipose and trophoblast cells.	Eicosapentaenoic Acid	167-170	C-X-C motif chemokine ligand 8	Homo sapiens	219-222
26255641-10	2015	As compared to the diffusivity of Li in other common inorganic SEI compounds, such as Li2CO3 and Li2O, the cation diffusivity in LiF and NaF is quite low, with at least three orders of magnitude lower ionic conductivities.	Lithium Carbonate	86-92	C-X-C motif chemokine ligand 8	Homo sapiens	137-140
26340264-7	2015	The adipose tissue and placenta of treated women exhibited a significant decrease in TLR4 adipose and placental expression as well as IL6, IL8, and TNFalpha In vitro, EPA and DHA suppressed the activation of TLR4, IL6, IL8 induced by palmitate in culture of adipose and trophoblast cells.	Docosahexaenoic Acids	175-178	C-X-C motif chemokine ligand 8	Homo sapiens	139-142
26340264-7	2015	The adipose tissue and placenta of treated women exhibited a significant decrease in TLR4 adipose and placental expression as well as IL6, IL8, and TNFalpha In vitro, EPA and DHA suppressed the activation of TLR4, IL6, IL8 induced by palmitate in culture of adipose and trophoblast cells.	Docosahexaenoic Acids	175-178	C-X-C motif chemokine ligand 8	Homo sapiens	219-222
25894228-11	2015	Concomitant treatment of SZ95 sebocytes with APS attenuated the effect of IL-1beta and TNF-alpha on IL-6 and IL-8 gene expression as well as on IL-1beta-mediated NF-kappaB signaling.	aps	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
26665398-0	2015	THE EFFECT OF SULFASALAZINE AND 5-AMINOSALICYLIC ACID ON THE SECRETION OF INTERLEUKIN 8 BY HUMAN COLON MYOFIBROBLASTS.	Sulfasalazine	14-27	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
26665398-0	2015	THE EFFECT OF SULFASALAZINE AND 5-AMINOSALICYLIC ACID ON THE SECRETION OF INTERLEUKIN 8 BY HUMAN COLON MYOFIBROBLASTS.	Mesalamine	32-53	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
25894228-6	2015	Here, we investigated if APS attenuates IL-1beta- or TNF-alpha-mediated IL-6 and IL-8 expression in SZ95 sebocytes, whereas TNF-alpha was used as control.	aps	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
26072364-13	2015	Our results demonstrate that changes in HA morphology and carbonate content influence breast cancer cell growth and interleukin-8 secretion, and suggest that characterizing the effect of HA properties on breast cancer cells may improve our understanding of breast cancer development and progression.	Carbonates	58-67	C-X-C motif chemokine ligand 8	Homo sapiens	116-129
25582838-3	2015	As a readout for receptor signaling, we observe the dynamics of calcium release in neutrophils following contact with the IL-8 coated surface.	Calcium	64-71	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
26136104-6	2015	The results revealed that treatment with YCG063 significantly inhibited the levels of IL-6, IL-8, MCP-1 and ICAM-1 in the PA-LPS-stimulated ARPE-19 cells.	YCG 063	41-47	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
26845056-10	2015	Furthermore, IL-8 and IL-25 levels are decreased following treatment with prednisone acetate.	Nisone	74-92	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
26202921-10	2015	MAIN RESULTS AND THE ROLE OF CHANCE: The long chain saturated fatty acids, stearic and palmitic (PA), stimulated the synthesis as well as the release of TNF-alpha, IL-6 and IL-8 by trophoblast cells (2- to 6-fold, P &lt; 0.001).	long chain saturated fatty acids	41-73	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
26202921-10	2015	MAIN RESULTS AND THE ROLE OF CHANCE: The long chain saturated fatty acids, stearic and palmitic (PA), stimulated the synthesis as well as the release of TNF-alpha, IL-6 and IL-8 by trophoblast cells (2- to 6-fold, P &lt; 0.001).	stearic	75-82	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
26202921-10	2015	MAIN RESULTS AND THE ROLE OF CHANCE: The long chain saturated fatty acids, stearic and palmitic (PA), stimulated the synthesis as well as the release of TNF-alpha, IL-6 and IL-8 by trophoblast cells (2- to 6-fold, P &lt; 0.001).	Protactinium	97-99	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
26143497-8	2015	Also, galactose disrupted this inhibition on the expression of IL-8 and hBD-2.	Galactose	6-15	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
25726004-3	2015	So, we conducted this study with the purpose of investigating the effect of sodium fluoride (NaF) in human RPMI8226 cells.	Sodium Fluoride	76-91	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
25982554-4	2015	When the human intestinal epithelial cell-line, Caco-2, and the primary colon cells were stimulated with ethanol-inactivated S. aureus, IL-8 expression was induced in a dose-dependent manner.	Ethanol	105-112	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
26400525-9	2015	CONCLUSIONS: Clinical efficacy of TACE and patient survival in liver cancer are associated with specific variants of IL-8 and IL-10 genes.	Chlorotrianisene	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
25977183-6	2015	Moreover, pretreatment of NHEKs with Z-lig reduced UVB-induced nuclear factor kappa B (NF-kappaB)-dependent inflammatory mediators (IL-6, IL-8 and MCP-1) production at both mRNA and protein level.	ligustilide	37-42	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
25828268-12	2015	MitoQ and Tiron inhibited TGF-beta-induced ASM cell proliferation and CXCL8 release.	mitoquinone	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	70-75
26617775-4	2015	We observed in HK-2 cells that fenofibrate significantly inhibited fatty acids bound albumin (FA-BSA) induced up-regulation of MCP-1 and IL-8.	Fenofibrate	31-42	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
26617775-4	2015	We observed in HK-2 cells that fenofibrate significantly inhibited fatty acids bound albumin (FA-BSA) induced up-regulation of MCP-1 and IL-8.	Fatty Acids	67-78	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
25828268-12	2015	MitoQ and Tiron inhibited TGF-beta-induced ASM cell proliferation and CXCL8 release.	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt	10-15	C-X-C motif chemokine ligand 8	Homo sapiens	70-75
26044852-5	2015	RESULTS: Inhibition of LPS-induced CXCL8 and TNF-alpha expression by IL-10 proceeds through a common mechanism targeting LPS-induced phosphorylation of the nuclear factor kappaB p65 serine 276 residue (pS276p65).	Serine	182-188	C-X-C motif chemokine ligand 8	Homo sapiens	35-40
25754990-0	2015	Inhibition of PKC-Induced COX-2 and IL-8 Expression in Human Breast Cancer Cells by Glucosamine.	Glucosamine	84-95	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
25689957-0	2015	IL-1ss and IL-8 are scavenged by the hexadecylamide derivative of hyaluronic acid: a new mechanism.	hexadecylamide	37-51	C-X-C motif chemokine ligand 8	Homo sapiens	0-15
25689957-0	2015	IL-1ss and IL-8 are scavenged by the hexadecylamide derivative of hyaluronic acid: a new mechanism.	Hyaluronic Acid	66-81	C-X-C motif chemokine ligand 8	Homo sapiens	0-15
25754990-5	2015	In MCF-7 breast cancer cells, glucosamine effectively suppresses the PKC induction of COX-2 and IL-8 promoter activity, mRNA and protein levels, as well as the production of prostaglandin E(2) (PGE(2)) and IL-8.	Glucosamine	30-41	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
25754990-4	2015	The aim of this study was to clarify the role and acting mechanism of glucosamine during the PKC-regulation of COX-2/IL-8 expression and the associated impact on breast cancer.	Glucosamine	70-81	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
25754990-5	2015	In MCF-7 breast cancer cells, glucosamine effectively suppresses the PKC induction of COX-2 and IL-8 promoter activity, mRNA and protein levels, as well as the production of prostaglandin E(2) (PGE(2)) and IL-8.	Glucosamine	30-41	C-X-C motif chemokine ligand 8	Homo sapiens	206-210
26202982-8	2015	SYK kinase and the adaptor protein CARD9 were essential for glycolipid-induced IL-8 production.	Glycolipids	60-70	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
25754990-10	2015	Furthermore, glucosamine significantly inhibits the growth of breast cancer xenografts and this is accompanied by a reduction in COX-2 and IL-8 expression.	Glucosamine	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
24888491-0	2015	Alpha-mangostin suppresses IL-6 and IL-8 expression in P. gingivalis LPS-stimulated human gingival fibroblasts.	mangostin	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
26426613-10	2015	Levels of IL-6, IL-1beta, and IL-8 detected in NPA from RSV single and associated to HRV were significantly higher than HRV infected and positively associated with days requiring O2.Levels of IL-6, IL-1beta, and IL-8 detected in NPA from patients infected with RSV only or with both RSV and HRV are increased, and any of those 3 cytokines may have a predictive value for the number of days with need of supplemental oxygen.	Oxygen	179-181	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
25876063-5	2015	Osthole was able to suppress the levels of proinflammatory cytokines interleukin (IL)-1beta and IL-6, as well as chemokines monocyte chemoattractant protein-1 and IL-8.	osthol	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
26024755-0	2015	Niacin inhibits fat accumulation, oxidative stress, and inflammatory cytokine IL-8 in cultured hepatocytes: Impact on non-alcoholic fatty liver disease.	Niacin	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
26024755-7	2015	Niacin reduced palmitic acid-induced IL-8 levels.	Niacin	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
26024755-7	2015	Niacin reduced palmitic acid-induced IL-8 levels.	Palmitic Acid	15-28	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
26024755-9	2015	Decreased ROS production, at least in part, may have contributed to the inhibition of pro-inflammatory IL-8 levels.	Reactive Oxygen Species	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
24888491-1	2015	This study aims to investigate the effect of alpha-mangostin on interleukin (IL)-6 and IL-8 expression in human gingival fibroblasts (HGFs).	mangostin	45-60	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
24888491-5	2015	Alpha-mangostin reduced IL-6 and IL-8 mRNA and protein in P. gingivalis LPS-stimulated HGFs.	mangostin	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
26008221-0	2015	Arsenic exposure causes epigenetic dysregulation of IL-8 expression leading to proneoplastic changes in kidney cells.	Arsenic	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
26032617-3	2015	Molecular imaging using (18)F-sodium fluoride ((18)F-NaF) positron emission tomography (PET)/computed tomography (CT) has been recently proposed as a marker to study the in vivo mineralization process in the atheroma plaque.	Sodium Fluoride	30-45	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
26008221-3	2015	In this work, we have studied the effect of arsenic exposure on renal system using human embryonic kidney cells and prenatally exposed animals and identified Interleukin-8(IL-8) and its homologue (CINC-1) as mediators of arsenic induced renal toxicity.	Arsenic	221-228	C-X-C motif chemokine ligand 8	Homo sapiens	158-171
26008221-3	2015	In this work, we have studied the effect of arsenic exposure on renal system using human embryonic kidney cells and prenatally exposed animals and identified Interleukin-8(IL-8) and its homologue (CINC-1) as mediators of arsenic induced renal toxicity.	Arsenic	221-228	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
26008221-4	2015	We further show that embryonic kidney cells are more responsive to arsenic leading to higher induction of IL-8 as compared to adult cells due to DNA methylation and histone acetylation (H3 acetylation) changes in the IL-8 promoter.	Arsenic	67-74	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
26008221-4	2015	We further show that embryonic kidney cells are more responsive to arsenic leading to higher induction of IL-8 as compared to adult cells due to DNA methylation and histone acetylation (H3 acetylation) changes in the IL-8 promoter.	Arsenic	67-74	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
26008221-5	2015	Through bisulfite analysis of the IL-8 promoter, we have also identified an arsenic modulated CpG site at -168 bases upstream of transcription start site.	hydrogen sulfite	8-17	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
26008221-5	2015	Through bisulfite analysis of the IL-8 promoter, we have also identified an arsenic modulated CpG site at -168 bases upstream of transcription start site.	Arsenic	76-83	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
26008221-6	2015	This CpG is associated with C/EBP and CREB binding sites in the IL-8 promoter and its demethylation by arsenic coupled with increased H3 histone acetylation and CBP/P300 recruitment could lead to induction of IL-8.	Arsenic	103-110	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
26008221-6	2015	This CpG is associated with C/EBP and CREB binding sites in the IL-8 promoter and its demethylation by arsenic coupled with increased H3 histone acetylation and CBP/P300 recruitment could lead to induction of IL-8.	Arsenic	103-110	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
26008221-7	2015	Our study shows how epigenetic modulation of IL-8 by arsenic could contribute to increased cell migratory and proliferative capabilities, cell cycle dysregulation and renal toxicity.	Arsenic	53-60	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
26269716-6	2015	We found that IL6, TNF, CXCL8, IL1B and ERK1/2 were the top genes in terms of the number of connections in platinum-induced neuropathy and TP53, MYC, PARP1, P38 MAPK and TNF for combined taxane-platinum-induced neuropathy.	Platinum	107-115	C-X-C motif chemokine ligand 8	Homo sapiens	24-29
26215482-2	2015	Herein, we have investigated the effect of specific monovalent Hofmeister salts (NaH2PO4, NaF, NaCl, NaClO4, and NaSCN) on the coil-globule transition of poly(N-isopropylacrylamide) (PNIPAM) in a crowded macromolecular environment as a model for understanding the specific-ion effect on the solubility and stability of proteins in a crowded macromolecular environment.	poly-N-isopropylacrylamide	154-181	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
26215482-3	2015	It was found that although the salts (NaH2PO4, NaF, and NaCl) and the macromolecular crowder (polyethylene glycol) lowered the transition temperature almost independently, the macromolecular crowder had a great impact on the transition temperature in the case of the chaotropes (NaClO4 and NaSCN).	sodium perchlorate	279-285	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
26215482-3	2015	It was found that although the salts (NaH2PO4, NaF, and NaCl) and the macromolecular crowder (polyethylene glycol) lowered the transition temperature almost independently, the macromolecular crowder had a great impact on the transition temperature in the case of the chaotropes (NaClO4 and NaSCN).	sodium thiocyanate	290-295	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
26269716-6	2015	We found that IL6, TNF, CXCL8, IL1B and ERK1/2 were the top genes in terms of the number of connections in platinum-induced neuropathy and TP53, MYC, PARP1, P38 MAPK and TNF for combined taxane-platinum-induced neuropathy.	taxane	187-193	C-X-C motif chemokine ligand 8	Homo sapiens	24-29
26269716-6	2015	We found that IL6, TNF, CXCL8, IL1B and ERK1/2 were the top genes in terms of the number of connections in platinum-induced neuropathy and TP53, MYC, PARP1, P38 MAPK and TNF for combined taxane-platinum-induced neuropathy.	Platinum	194-202	C-X-C motif chemokine ligand 8	Homo sapiens	24-29
26079696-7	2015	Moreover, we detected increased levels of interleukin (IL)-6 and IL-8 released in the 3 aldehyde exposure groups.	Aldehydes	88-96	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
26086093-0	2015	27-Oxygenated cholesterol induces expression of CXCL8 in macrophages via NF-kappaB and CD88.	Cholesterol	14-25	C-X-C motif chemokine ligand 8	Homo sapiens	48-53
26086093-1	2015	We attempted to determine the effects of a milieu rich in cholesterol molecules on expression of chemokine CXCL8.	Cholesterol	58-69	C-X-C motif chemokine ligand 8	Homo sapiens	107-112
26086093-2	2015	A high-cholesterol diet led to an increased transcription of the IL-8 gene in the arteries and elevated levels of CXCL8 in sera of ApoE(-/-) mice, compared with those of wild-type C57BL/6 mice.	Cholesterol	7-18	C-X-C motif chemokine ligand 8	Homo sapiens	114-119
26086093-3	2015	Treatment of THP-1 monocyte/macrophage cells with 27-hydroxycholesterol (27OHChol) resulted in transcription of the IL-8 gene and increased secretion of its corresponding gene product whereas cholesterol did not induce expression of CXCL8 in THP-1 cells.	27-hydroxycholesterol	50-71	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
26086093-3	2015	Treatment of THP-1 monocyte/macrophage cells with 27-hydroxycholesterol (27OHChol) resulted in transcription of the IL-8 gene and increased secretion of its corresponding gene product whereas cholesterol did not induce expression of CXCL8 in THP-1 cells.	27ohchol	73-81	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
26086093-3	2015	Treatment of THP-1 monocyte/macrophage cells with 27-hydroxycholesterol (27OHChol) resulted in transcription of the IL-8 gene and increased secretion of its corresponding gene product whereas cholesterol did not induce expression of CXCL8 in THP-1 cells.	Cholesterol	60-71	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
26086093-3	2015	Treatment of THP-1 monocyte/macrophage cells with 27-hydroxycholesterol (27OHChol) resulted in transcription of the IL-8 gene and increased secretion of its corresponding gene product whereas cholesterol did not induce expression of CXCL8 in THP-1 cells.	Cholesterol	60-71	C-X-C motif chemokine ligand 8	Homo sapiens	233-238
26086093-4	2015	27OHChol-induced transcription of the IL-8 gene was blocked by cycloheximide, but not by polymyxin B.	27ohchol	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
26086093-4	2015	27OHChol-induced transcription of the IL-8 gene was blocked by cycloheximide, but not by polymyxin B.	Cycloheximide	63-76	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
26086093-6	2015	Inhibition of NF-kappaB and CD88 using SN50 and W-54011, respectively, resulted in reduced transcription of the IL-8 gene and attenuated secretion of CXCL8 induced by 27OHChol.	27ohchol	167-175	C-X-C motif chemokine ligand 8	Homo sapiens	150-155
26086093-7	2015	We propose that oxidatively modified cholesterol like 27OHChol, rather than cholesterol, is responsible for sustained expression of CXCL8 in monocytes/macrophages in atherosclerotic arteries.	Cholesterol	37-48	C-X-C motif chemokine ligand 8	Homo sapiens	132-137
26086093-7	2015	We propose that oxidatively modified cholesterol like 27OHChol, rather than cholesterol, is responsible for sustained expression of CXCL8 in monocytes/macrophages in atherosclerotic arteries.	27ohchol	54-62	C-X-C motif chemokine ligand 8	Homo sapiens	132-137
26047642-5	2015	Conditioned medium from BK treated HASMC induced CXCL8, VEGF, and COX-2 mRNA and protein accumulation in airway epithelial cells, which were blocked by anti-amphiregulin antibodies and amphiregulin siRNA, suggesting a paracrine effect of HASMC-derived amphiregulin on airway epithelial cells.	hasmc	35-40	C-X-C motif chemokine ligand 8	Homo sapiens	49-54
26047642-8	2015	Our study provides evidence of a dynamic axis of interaction between HASMC and epithelial cells that amplifies CXCL8, VEGF, COX-2, and amphiregulin production.	hasmc	69-74	C-X-C motif chemokine ligand 8	Homo sapiens	111-116
25797323-9	2015	CRP, 8-isoprostane and LTB4 levels in serum, and IL-8 concentration in EBC correlated negatively with the value of forced expiratory volume in one second.	NSC638702	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
26002274-1	2015	A fully automated production of the imaging agent sodium [(18)F]fluoride ([(18)F]NaF) on two different modules commercialized by Trasis , the AllInOne and the miniAllInOne, is reported.	sodium [(18)f]fluoride	50-72	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
25891413-6	2015	RV1088 was also significantly more effective at inhibiting IL-6 and IL-8 production by monocytes and RA synovial fibroblasts compared with Humira.	RV1088	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
25891413-7	2015	Finally, RV1088 was the only inhibitor that was effective in reducing TNF-alpha, IL-6 and IL-8 synthesis in RA synovial membrane cells with low nM IC50 s. CONCLUSIONS AND IMPLICATIONS: This study demonstrates potent anti-inflammatory effect of RV1088, highlighting that distinct signalling pathways drive TNF-alpha, IL-6 and IL-8 production in the different cell types found in RA joints.	RV1088	9-15	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
25891413-7	2015	Finally, RV1088 was the only inhibitor that was effective in reducing TNF-alpha, IL-6 and IL-8 synthesis in RA synovial membrane cells with low nM IC50 s. CONCLUSIONS AND IMPLICATIONS: This study demonstrates potent anti-inflammatory effect of RV1088, highlighting that distinct signalling pathways drive TNF-alpha, IL-6 and IL-8 production in the different cell types found in RA joints.	RV1088	9-15	C-X-C motif chemokine ligand 8	Homo sapiens	325-329
26179154-4	2015	In early (first-third) passages, IL-6 and IL-8 concentration was higher at 20% O2 and in late (8th-12th) passages under 5% O2.	Oxygen	79-81	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
26179154-4	2015	In early (first-third) passages, IL-6 and IL-8 concentration was higher at 20% O2 and in late (8th-12th) passages under 5% O2.	Oxygen	123-125	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
25898227-8	2015	Long-term exposure to NOx was associated with decreased levels of interleukin (IL)-2, IL-8, IL-10 and tumor necrosis factor-alpha in Italy, but not in Sweden.	Nitrogen Oxides	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
25898227-10	2015	Combining data from Italy and Sweden we only observed a significant association between long-term exposure to NOx and decreased levels of circulating IL-8.	Nitrogen Oxides	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
26102216-6	2015	Our results show that the water extract from red vine leaves inhibits TNFalpha-induced IL-8 secretion and expression in human gastric epithelial cells; the effect should be maintained, although to a lesser extent, after gastric digestion.	Water	26-31	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
26102216-9	2015	Our findings suggest that PFS containing water extracts from Vitis vinifera L. leaves could be useful to inhibit/attenuate gastric inflammation inhibiting IL-8 secretion and expression through impairment of the NF-kappaB pathway.	Water	41-46	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
26190093-4	2015	Resveratrol can both decrease the secretion of proinflammatory cytokines (e.g., IL-6, IL-8, and TNF-alpha) and increase the production of anti-inflammatory cytokines; it also decreases the expression of adhesion proteins (e.g., ICAM-1) and leukocyte chemoattractants (e.g., MCP-1).	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
26349982-4	2015	Mechanistic studies revealed that BDMC-A might have exerted its activity by inhibiting metastatic and angiogenic pathways by modulating the expression of proteins upstream to NF-kappaB (TGF-beta, TNF-alpha, IL-1beta and c-Src), and NF-kappaB signaling cascade (c-Rel, COX-2, MMP-9, VEGF, IL-8) and by upregulating TIMP-2 levels.	BDMC-A	34-40	C-X-C motif chemokine ligand 8	Homo sapiens	288-292
26672320-5	2015	The results show that trace fluoride phase mainly includes NaF, KF, CaF2, K2SiF6, Na2SiF6, Na3AlF6, K3AlF6, AlF3   3H2O, AlF2.3(OH)0.7   H2O, Ca5(PO4)3F, Ca10(PO4)6F2.	Fluorides	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	59-62
25962642-9	2015	Within 2-4 h, Ag increased superoxide anion release and stimulated cytokine production (MCP-1, IL-8) that was diminished by Ca2+ inhibitors or trolox.	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	143-149	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
26244291-6	2015	Sorafenib significantly inhibited production of TGF-beta1, VEGF, IL-6, IL-8, MCP-1, and TNF-alpha and blocked the activation of migration-related signaling molecules, such as HIF-1alpha, p-STAT3, MMP2, and Ang-1.	Sorafenib	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
25503516-2	2015	Interleukin 8 (IL-8) released from macrophages is a key chemokine during initiation and progression of CS-induced lung inflammation, yet its regulation is largely unknown.	Cesium	103-105	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
25503516-2	2015	Interleukin 8 (IL-8) released from macrophages is a key chemokine during initiation and progression of CS-induced lung inflammation, yet its regulation is largely unknown.	Cesium	103-105	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
25503516-4	2015	Here we report that CS extract (CSE) increased the level of intracellular reactive oxygen species (ROS), activating AMPK, mitogen-activated protein kinases (MAPKs), and NF-kappaB, as well as inducing IL-8, in human macrophages.	Cesium	20-22	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
25503516-5	2015	N-acetyl-cysteine (ROS scavenger) or hexamethonium [nicotinic acetylcholine receptor (nAChR) antagonist] attenuated the CSE-induced increase in intracellular ROS, activation of AMPK and NF-kappaB, as well as IL-8 induction, which suggests that nAChRs and ROS are important.	Acetylcysteine	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
25503516-5	2015	N-acetyl-cysteine (ROS scavenger) or hexamethonium [nicotinic acetylcholine receptor (nAChR) antagonist] attenuated the CSE-induced increase in intracellular ROS, activation of AMPK and NF-kappaB, as well as IL-8 induction, which suggests that nAChRs and ROS are important.	Reactive Oxygen Species	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
25503516-5	2015	N-acetyl-cysteine (ROS scavenger) or hexamethonium [nicotinic acetylcholine receptor (nAChR) antagonist] attenuated the CSE-induced increase in intracellular ROS, activation of AMPK and NF-kappaB, as well as IL-8 induction, which suggests that nAChRs and ROS are important.	Hexamethonium	37-50	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
25503516-5	2015	N-acetyl-cysteine (ROS scavenger) or hexamethonium [nicotinic acetylcholine receptor (nAChR) antagonist] attenuated the CSE-induced increase in intracellular ROS, activation of AMPK and NF-kappaB, as well as IL-8 induction, which suggests that nAChRs and ROS are important.	Reactive Oxygen Species	158-161	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
25503516-5	2015	N-acetyl-cysteine (ROS scavenger) or hexamethonium [nicotinic acetylcholine receptor (nAChR) antagonist] attenuated the CSE-induced increase in intracellular ROS, activation of AMPK and NF-kappaB, as well as IL-8 induction, which suggests that nAChRs and ROS are important.	Reactive Oxygen Species	158-161	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
25822580-4	2015	Co-stimulation with IFN-gamma and the TLR3 ligand poly (I:C) synergistically increased the expression of IFN-beta, IL-6, IL-8, and human beta-defensin-2 in NHEKs compared with poly (I:C) or IFN-gamma alone.	poly	50-54	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
25822580-4	2015	Co-stimulation with IFN-gamma and the TLR3 ligand poly (I:C) synergistically increased the expression of IFN-beta, IL-6, IL-8, and human beta-defensin-2 in NHEKs compared with poly (I:C) or IFN-gamma alone.	Iodine	20-21	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
25822580-4	2015	Co-stimulation with IFN-gamma and the TLR3 ligand poly (I:C) synergistically increased the expression of IFN-beta, IL-6, IL-8, and human beta-defensin-2 in NHEKs compared with poly (I:C) or IFN-gamma alone.	Carbon	0-1	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
25817444-7	2015	Targeting these newly identified signals, including AR, IL8, or miRNA32, may help us to better suppress PCa NE differentiation that is induced during ADT with anti-androgen enzalutamide (or casodex) treatment.	enzalutamide	173-185	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
25817444-7	2015	Targeting these newly identified signals, including AR, IL8, or miRNA32, may help us to better suppress PCa NE differentiation that is induced during ADT with anti-androgen enzalutamide (or casodex) treatment.	bicalutamide	190-197	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
25840438-0	2015	Enterococcus faecalis lipoteichoic acid suppresses Aggregatibacter actinomycetemcomitans lipopolysaccharide-induced IL-8 expression in human periodontal ligament cells.	lipoteichoic acid	22-39	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
26117190-6	2015	The expression of interleukin-8 (IL-8) from Calu-3 induced with tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta1) and lipopolysaccharide (LPS) were significantly reduced after treatment with spray-dried resveratrol.	Resveratrol	238-249	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
26117190-6	2015	The expression of interleukin-8 (IL-8) from Calu-3 induced with tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta1) and lipopolysaccharide (LPS) were significantly reduced after treatment with spray-dried resveratrol.	Resveratrol	238-249	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
25503516-8	2015	Additionally, exposure of human macrophages to nicotine activated AMPK and induced IL-8 and that these effects were lessened by hexamethonium or compound C, implying that nicotine in CS may be causative.	Nicotine	47-55	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
25503516-10	2015	Thus, we identified a novel nAChRs-dependent, ROS-sensitive, AMPK/MAPKs/NF-kappaB signaling pathway, which seems to be important to CS-induced macrophage IL-8 production and possibly to lung inflammation.	nachrs	28-34	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
25503516-10	2015	Thus, we identified a novel nAChRs-dependent, ROS-sensitive, AMPK/MAPKs/NF-kappaB signaling pathway, which seems to be important to CS-induced macrophage IL-8 production and possibly to lung inflammation.	Reactive Oxygen Species	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
25503516-10	2015	Thus, we identified a novel nAChRs-dependent, ROS-sensitive, AMPK/MAPKs/NF-kappaB signaling pathway, which seems to be important to CS-induced macrophage IL-8 production and possibly to lung inflammation.	Cesium	132-134	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
26436037-14	2015	The Fluoride re release was high when recharging with professional regime (2% NaF) as compared to home regime (Toothpaste).	Fluorides	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	78-81
25954992-6	2015	The release of IL-8 from the A549 cells was assessed following treatment with EtP (2.5-10 mM), sodium pyruvate (NaP; 10 mM) or EtOH (85-170 mM) for 1, 24 or 72 h, prior to and following IL-6 stimulation.	ethyl pyruvate	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
25954992-6	2015	The release of IL-8 from the A549 cells was assessed following treatment with EtP (2.5-10 mM), sodium pyruvate (NaP; 10 mM) or EtOH (85-170 mM) for 1, 24 or 72 h, prior to and following IL-6 stimulation.	SODIUM PYRUVATE	95-110	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
25954992-6	2015	The release of IL-8 from the A549 cells was assessed following treatment with EtP (2.5-10 mM), sodium pyruvate (NaP; 10 mM) or EtOH (85-170 mM) for 1, 24 or 72 h, prior to and following IL-6 stimulation.	N-(4-aminophenethyl)spiroperidol	112-115	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
25954992-6	2015	The release of IL-8 from the A549 cells was assessed following treatment with EtP (2.5-10 mM), sodium pyruvate (NaP; 10 mM) or EtOH (85-170 mM) for 1, 24 or 72 h, prior to and following IL-6 stimulation.	Ethanol	127-131	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
25954992-8	2015	Treatment of the A549 cells with either EtOH or EtP significantly reduced the IL-6-induced release of IL-8.	Ethanol	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
25954992-8	2015	Treatment of the A549 cells with either EtOH or EtP significantly reduced the IL-6-induced release of IL-8.	ethyl pyruvate	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
25937253-14	2015	Consistent with the results of in vivo experiment, piscroside C significantly inhibited the expression of inflammatory cytokines (IL-6, IL-8 and IL-1beta) by inhibiting NF-kappaB activation, as resulting decrease in the phosphorylation of IKKbeta, IkappaBalpha and TAK1 in TNF-alpha-stimulated H292 cells.	piscroside C	51-63	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
26207385-9	2015	Vitamin D inhibited TNFalpha-induced IL8 protein secretion levels to a comparable degree in fatal asthma- and non-asthma-derived ASM even though IL8 had significantly higher baseline levels in fatal asthma-derived ASM.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
26079480-5	2015	Trp-His inhibited interleukin (IL)-8 secretion in tumor necrosis factor (TNF)-alpha-stimulated HT-29 cells.	tryptophyl-histidine	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	18-36
26196332-7	2015	In conclusion, perioperative adjunctive use of dexmedetomidine substantially decreases serum IL-6, IL-8 and TNF-alpha levels.	Dexmedetomidine	47-62	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
26668998-7	2015	In vitro, levels of AMPKalpha phosphorylation in phorbol-12- myristate-13-acetate (PMA) differentiated THP-1 cells was detected by immunohistochemistry, IL-8 level in supernatants of cigarette smoke condensate stimulating PMA differentiated THP-1 cells was measured by ELISA.	Tetradecanoylphorbol Acetate	49-81	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
26182292-2	2015	Our previous studies have proved that activation of P2Y2 receptor by extracellular ATP could promote prostate cancer cell invasion and metastasis in vitro and in vivo via regulating the expressions of some epithelial-mesenchymal transition/invasion-related genes (including IL-8, E-cadherin, Snail and Claudin-1), and the most significant change in expression of IL-8 was observed after P2Y2 receptor activation.	Adenosine Triphosphate	83-86	C-X-C motif chemokine ligand 8	Homo sapiens	274-278
26182292-2	2015	Our previous studies have proved that activation of P2Y2 receptor by extracellular ATP could promote prostate cancer cell invasion and metastasis in vitro and in vivo via regulating the expressions of some epithelial-mesenchymal transition/invasion-related genes (including IL-8, E-cadherin, Snail and Claudin-1), and the most significant change in expression of IL-8 was observed after P2Y2 receptor activation.	Adenosine Triphosphate	83-86	C-X-C motif chemokine ligand 8	Homo sapiens	363-367
26182292-6	2015	Further experiments showed that inactivation of EGFR and ERK1/2 attenuated ATP-induced invasion and migration, and suppressed ATP-mediated IL-8 production.	Adenosine Triphosphate	126-129	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
26182292-7	2015	In addition, knockdown of IL-8 inhibited ATP-mediated invasion and migration of prostate cancer cells.	Adenosine Triphosphate	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
26151378-3	2015	Positron emission tomography and X-ray computed tomography (PET/CT) imaging of atherosclerosis using (18)F-sodium fluoride ((18)F-NaF) has the potential to identify pathologically high-risk nascent microcalcification.	Sodium Fluoride	107-122	C-X-C motif chemokine ligand 8	Homo sapiens	130-133
26138903-8	2015	Honokiol showed an anti-inflammatory effect in PA-inducted HUVECs by significantly inhibiting the generation of interleukin-6 (IL-6), IL-8 and monocyte chemoattractant protein-1.	honokiol	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
26138903-8	2015	Honokiol showed an anti-inflammatory effect in PA-inducted HUVECs by significantly inhibiting the generation of interleukin-6 (IL-6), IL-8 and monocyte chemoattractant protein-1.	Palmitic Acid	47-49	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
26133108-8	2015	(iv) The reactive oxygen species (ROS) H2O2 (hydrogen peroxide) enhanced the LIGHT-mediated release of IL-8 in Huh7 hepatocytes.	Hydrogen Peroxide	45-62	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
25749775-13	2015	Dexamethasone, calcitriol, anti-MD2/anti-TLR2 antibodies, and signalling inhibitors significantly reduced LPS+Der p2-induced IL-6/IL-8 secretion.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
26133108-8	2015	(iv) The reactive oxygen species (ROS) H2O2 (hydrogen peroxide) enhanced the LIGHT-mediated release of IL-8 in Huh7 hepatocytes.	Hydrogen Peroxide	39-43	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
26133108-8	2015	(iv) The reactive oxygen species (ROS) H2O2 (hydrogen peroxide) enhanced the LIGHT-mediated release of IL-8 in Huh7 hepatocytes.	Reactive Oxygen Species	9-32	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
26133108-8	2015	(iv) The reactive oxygen species (ROS) H2O2 (hydrogen peroxide) enhanced the LIGHT-mediated release of IL-8 in Huh7 hepatocytes.	Reactive Oxygen Species	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
25626738-9	2015	Lower levels of MCP-1 and IL-8 (P &lt; 0.001) and higher levels of IL-6 and MMP-9 (P = 0.003) were found in the sevoflurane group, compared with the TIVA group 30 min post-operatively.	Sevoflurane	112-123	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
25749775-13	2015	Dexamethasone, calcitriol, anti-MD2/anti-TLR2 antibodies, and signalling inhibitors significantly reduced LPS+Der p2-induced IL-6/IL-8 secretion.	Calcitriol	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
25934456-6	2015	Notably, this interaction between dimensionality and oxygen status via IL-8 increased angiogenic sprouting in a 3D endothelial invasion assay.	Oxygen	53-59	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
25191838-10	2015	With regard to the mouthwash solutions, the lowest amounts of metal ions were released in CHX, and the highest amounts of metal ions were released in NaF + alcohol.	Metals	122-127	C-X-C motif chemokine ligand 8	Homo sapiens	150-153
25191838-10	2015	With regard to the mouthwash solutions, the lowest amounts of metal ions were released in CHX, and the highest amounts of metal ions were released in NaF + alcohol.	Alcohols	156-163	C-X-C motif chemokine ligand 8	Homo sapiens	150-153
25944880-10	2015	Palmitate, but not palmitoleate, elevated the expression of IL-6, IL-8, TLR2 (Toll-like receptor 2), and intercellular adhesion molecule 1 (ICAM-1).	Palmitates	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
25930720-10	2015	After 8 weeks of pidotimod treatment, IL-8 was increased compared to either tiapride hydrochloride or haloperidol and pidotimod (P < 0.05).	pidotimod	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
25929446-4	2015	Phloretin treatment decreased the production of IL-6, IL-8, CCL5, MDC, and TARC.	Phloretin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
26018711-1	2015	Sodium 18F-fluoride (NaF) is a diagnostic marker for new bone formation in bone scintigraphy that was approved by US FDA in 1972 but discontinued in 1984.	SODIUM FLUORIDE F-18	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
25458745-8	2015	IL-8 was significantly lower in Group HES than Group GEL at T1 (p=0.0005).	Helium	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
26073057-8	2015	Furthermore, TRF from MGSO markedly reduced LPS-induced proinflammatory gene expression in human adipocytes and cytokine secretion to the medium (IL-6 and IL-8).	mgso	22-26	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
25545021-6	2015	Inhibition of KCa3.1 by the selective, pore-blocking inhibitor TRAM-34, (and, in part, by siRNA) significantly reduced cell proliferation, as well as expression and secretion of pro-inflammatory factors (IL-6, IL-8, and MCP1) and the tissue-destructive protease MMP3.	TRAM 34	63-70	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
26339358-5	2015	Honokiol inhibited the expression levels of IL-1beta, TNF-alpha, GM-CSF and IL-8 in PBMCs with a dose-dependent manner.	honokiol	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
26339358-7	2015	Furthermore, the mRNA and protein expression of IL-1beta, GM-CSF and IL-8 were up-regulated when the PBMCs exposure to TNF-alpha, however, honokiol treatment significantly reversed the expression of IL-1beta, TNF-alpha and GM-CSF in response to TNF-alpha with a dose-dependent manner.	honokiol	139-147	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
26339358-8	2015	CONCLUSIONS: This study demonstrates that honokiol could possess potential anti-inflammatory effects and inhibits TNF-alpha-induced IL-1beta, GM-CSF and IL-8 production in PBMCs from rheumatoid arthritis patients.	honokiol	42-50	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
26019243-11	2015	Moreover, GOSs stabilized the expression and cellular distribution of claudin3 and suppressed by &gt;50% the deoxynivalenol-induced synthesis and release of interleukin-8 [IL8/chemokine CXC motif ligand (CXCL8)] (P &lt; 0.05).	deoxynivalenol	109-123	C-X-C motif chemokine ligand 8	Homo sapiens	157-170
25910974-4	2015	In this study poly(methyl methacrylate-divinylbenzene) (MMA-DVB) and poly(divinylbenzene) (DVB) were assessed with respect to their capacity to retain naphthalene (NAF) in continuous flow and batch processes (adsorption equilibrium and kinetics).	poly(methyl methacrylate-divinylbenzene)	14-54	C-X-C motif chemokine ligand 8	Homo sapiens	164-167
25910974-4	2015	In this study poly(methyl methacrylate-divinylbenzene) (MMA-DVB) and poly(divinylbenzene) (DVB) were assessed with respect to their capacity to retain naphthalene (NAF) in continuous flow and batch processes (adsorption equilibrium and kinetics).	poly(divinylbenzene)	69-89	C-X-C motif chemokine ligand 8	Homo sapiens	164-167
25952737-1	2015	UNLABELLED: Several studies have highlighted the role of vascular (18)F-NaF uptake as a marker of ongoing calcium deposition.	Calcium	106-113	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
26019243-11	2015	Moreover, GOSs stabilized the expression and cellular distribution of claudin3 and suppressed by &gt;50% the deoxynivalenol-induced synthesis and release of interleukin-8 [IL8/chemokine CXC motif ligand (CXCL8)] (P &lt; 0.05).	deoxynivalenol	109-123	C-X-C motif chemokine ligand 8	Homo sapiens	172-175
25952737-18	2015	CONCLUSION: Our results support the concept that (18)F-NaF is a feasible option in imaging molecular calcium deposition in the early stages of plaque formation, when active uptake mechanisms are the main determinants of calcium presence, but that retention of (18)F-NaF progressively decreases with increasing calcium deposition in the arterial wall.	Calcium	101-108	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
26019243-11	2015	Moreover, GOSs stabilized the expression and cellular distribution of claudin3 and suppressed by &gt;50% the deoxynivalenol-induced synthesis and release of interleukin-8 [IL8/chemokine CXC motif ligand (CXCL8)] (P &lt; 0.05).	deoxynivalenol	109-123	C-X-C motif chemokine ligand 8	Homo sapiens	204-209
25952737-18	2015	CONCLUSION: Our results support the concept that (18)F-NaF is a feasible option in imaging molecular calcium deposition in the early stages of plaque formation, when active uptake mechanisms are the main determinants of calcium presence, but that retention of (18)F-NaF progressively decreases with increasing calcium deposition in the arterial wall.	Calcium	220-227	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
25952737-18	2015	CONCLUSION: Our results support the concept that (18)F-NaF is a feasible option in imaging molecular calcium deposition in the early stages of plaque formation, when active uptake mechanisms are the main determinants of calcium presence, but that retention of (18)F-NaF progressively decreases with increasing calcium deposition in the arterial wall.	Calcium	220-227	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
26019243-12	2015	In mice, GOSs prevented the deoxynivalenol-induced mRNA overexpression of claudin3 (P = 0.022) and CXCL8 homolog keratinocyte hemoattractant (Kc) (Cxcl1) (P = 0.06) as well as the deoxynivalenol-induced morphologic defects.	deoxynivalenol	28-42	C-X-C motif chemokine ligand 8	Homo sapiens	99-104
25644373-0	2015	Recovery of urothelial mediator release but prolonged elevations in interleukin-8 and nitric oxide secretion following mitomycin C treatment.	Mitomycin	119-130	C-X-C motif chemokine ligand 8	Homo sapiens	68-81
26329674-8	2015	Serum IL-8 was highest in the SRDF group and reduced by IHVHF clearance.	srdf	30-34	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
26329674-10	2015	Receiver operating characteristic curve analysis demonstrated that serum IL-8 predicted steroid sensitivity with moderate accuracy (area under the curve = 0.79, 95% CI: 0.69-0.87).	Steroids	88-95	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
26329674-11	2015	IHVHF promotes remission in patients with steroid-resistant INS and it may be partly due to serum IL-8 clearance.	Steroids	42-49	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
25882540-4	2015	Confirmatory enzyme-linked immunosorbent assays (ELISAs) showed that PGF2alpha stimulated increased output of interleukin (IL) 1beta, IL6, IL8 (CXCL8) and monocyte chemotactic protein-1 (MCP1, also known as chemokine (c-c motif) ligand 2, CCL2) by HUSMCs isolated from both upper and lower uterine segments.	Dinoprost	69-78	C-X-C motif chemokine ligand 8	Homo sapiens	139-142
25882540-4	2015	Confirmatory enzyme-linked immunosorbent assays (ELISAs) showed that PGF2alpha stimulated increased output of interleukin (IL) 1beta, IL6, IL8 (CXCL8) and monocyte chemotactic protein-1 (MCP1, also known as chemokine (c-c motif) ligand 2, CCL2) by HUSMCs isolated from both upper and lower uterine segments.	Dinoprost	69-78	C-X-C motif chemokine ligand 8	Homo sapiens	144-149
25882540-10	2015	Inhibition of ERK reversed PGF2alpha-induced IL1beta, IL6 and CCL2 output, while inhibition of PI3K blocked the effect of PGF2alpha on IL6, CXCL8 and CCL2 output and inhibition of NF-kappaB reversed PGF2alpha-induced IL1beta and CCL2 output.	Dinoprost	122-131	C-X-C motif chemokine ligand 8	Homo sapiens	140-145
25882540-10	2015	Inhibition of ERK reversed PGF2alpha-induced IL1beta, IL6 and CCL2 output, while inhibition of PI3K blocked the effect of PGF2alpha on IL6, CXCL8 and CCL2 output and inhibition of NF-kappaB reversed PGF2alpha-induced IL1beta and CCL2 output.	Dinoprost	122-131	C-X-C motif chemokine ligand 8	Homo sapiens	140-145
25881570-9	2015	Our results demonstrate that alantolactone from S. lappa suppresses TNF-alpha and IFN-gamma-induced production of RANTES and IL-8 by blocking STAT1 phosphorylation in HaCaT cells.	alantolactone	29-42	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
25644373-8	2015	A 326-fold increase in interleukin-8 secretion and significant increase in nitric oxide release were also detected at 24 h. One week after single and repeat MMC treatment, urothelial ATP, acetylcholine and PGE2 had recovered while the increase in nitric oxide and interleukin-8 was still evident.	Mitomycin	157-160	C-X-C motif chemokine ligand 8	Homo sapiens	23-36
25644373-8	2015	A 326-fold increase in interleukin-8 secretion and significant increase in nitric oxide release were also detected at 24 h. One week after single and repeat MMC treatment, urothelial ATP, acetylcholine and PGE2 had recovered while the increase in nitric oxide and interleukin-8 was still evident.	Mitomycin	157-160	C-X-C motif chemokine ligand 8	Homo sapiens	264-277
26112052-10	2015	However, steroid treatment significantly decreased pro-inflammatory cytokines IL-1beta, IL-8, TNF and IFN-gamma at the time of organ procurement.	Steroids	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
25746207-5	2015	The HIF-1alpha, AR, VEGF, and IL-8 were upregulated under 3% O2.	Oxygen	61-63	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
26132391-4	2015	Exposure of ciPTEC to cationic uremic toxins initiated production of the inflammatory cytokines IL-6 (117 +- 3%, p &lt; 0.001), IL-8 (122 +- 3%, p &lt; 0.001), and ET-1 (134 +- 5%, p &lt; 0.001).	ciptec	12-18	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
26085988-9	2015	Inhibitors of Ca(2+)-dependent PKC (Ro-31-8220 and Go6976) significantly abolished hyphae-induced expression of IL-8.	Go 6976	51-57	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
25904325-3	2015	Using HepG2 and primary human hepatocytes, we found that CHOP induces cell death and inflammatory responses after saturated free fatty acid exposure by activating NF-kappaB through a pathway involving IRAK2 expression, resulting in secretion of cytokines IL-8 and TNFalpha directly from hepatocytes.	saturated free fatty acid	114-139	C-X-C motif chemokine ligand 8	Homo sapiens	255-259
25818949-0	2015	Hyaluronic acid decreases IL-6 and IL-8 secretion and permeability in an inflammatory model of interstitial cystitis.	Hyaluronic Acid	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
26201230-1	2015	PURPOSE: To analyze whether immersion in sodium fluoride (NaF) solutions and/or common acidic beverages (test solutions) would affect the surface roughness or topography of lithium disilicate ceramic.	Lithium	173-180	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
25751232-9	2015	Patients in the carbon dioxide group had lower concentrations of serum and BALF interleukin (IL)-1, IL-6, and IL-8, but higher serum concentrations of IL-10, accompanied by reduced numbers of cells and neutrophils as well as lower concentrations of protein in the BALF.	Carbon Dioxide	16-30	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
26026083-4	2015	RESULTS: G1 arrest induced by SB265610 occurred at concentrations lacking CXCR2 selectivity, persisted upon interleukin 8 (IL8) challenge, and did not affect IL8 downstream target expression.	1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	108-121
26026083-4	2015	RESULTS: G1 arrest induced by SB265610 occurred at concentrations lacking CXCR2 selectivity, persisted upon interleukin 8 (IL8) challenge, and did not affect IL8 downstream target expression.	1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	123-126
25650123-10	2015	The IL-6 and IL-8 concentration was below the detection limit in all EBC samples.	NSC638702	69-72	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
26026083-9	2015	CONCLUSION: The present study described the mechanisms for the anti-proliferative activity of SB265610 which may be of value in IL8-rich tumor microenvironments.	1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea	94-102	C-X-C motif chemokine ligand 8	Homo sapiens	128-131
25619261-4	2015	In normal medium (0.4 mM calcium), citrate inhibited LPS-induced tumour necrosis factor (TNF)-alpha and interleukin (IL)-8 transcripts, whereas in medium supplemented with calcium (1.4 mM), TNF-alpha and IL-8 levels increased and appeared independent of calcium chelation.	Citric Acid	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	104-122
25619261-4	2015	In normal medium (0.4 mM calcium), citrate inhibited LPS-induced tumour necrosis factor (TNF)-alpha and interleukin (IL)-8 transcripts, whereas in medium supplemented with calcium (1.4 mM), TNF-alpha and IL-8 levels increased and appeared independent of calcium chelation.	Citric Acid	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
25619261-7	2015	In the presence of citrate, increased histone acetylation was observed in the TNF-alpha and IL-8 promoter regions of THP-1 cells.	Citric Acid	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
25996641-4	2015	Phloretin inhibited levels of prostaglandin E2, decreased COX-2 expression, and suppressed IL-8, monocyte chemotactic protein 1, and IL-6 production.	Phloretin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
25839901-5	2015	Treatment of THP-1 cells with extracts from 3R4F or pMRTP induced concentration-dependent increases in cytotoxicity (7-aminoactinomycin D), and inflammation (IL-8 and TNF-alpha).	pmrtp	52-57	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
26473163-11	2015	RSV concentration significantly correlated with both IL-8 and RANTES at all-time points.	Respiratory Syncytial Virus Vaccines	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
25803620-5	2015	Both intracellular and extracellular poly(I:C) induced the expression of IFNB, TNF, IL6, and IL8.	Poly I-C	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
26082895-15	2015	CONCLUSION: Our exploratory correlative studies indicate that CEC and IL-8 changes may be predictive for response to O + C and prognostic in recurrent platinum-sensitive OvCa, requiring prospective validation.	2-n-octyl-4-isothiazolin-3-one	117-122	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
25840641-12	2015	Pretreatment with U0126 (ERK inhibitor) but not rapamycin (mTOR inhibitor) abrogated the IL-9-mediated IL-8 production.	U 0126	18-23	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
26082895-15	2015	CONCLUSION: Our exploratory correlative studies indicate that CEC and IL-8 changes may be predictive for response to O + C and prognostic in recurrent platinum-sensitive OvCa, requiring prospective validation.	Platinum	151-159	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
25975581-4	2015	The anti-inflammatory effect of isoacteoside was investigated in HMC-1 cells by studying the following markers: phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-induced interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor alpha (TNF-alpha) secretion and mRNA expression by ELISA and RT-PCR, respectively.	isoacteoside	32-44	C-X-C motif chemokine ligand 8	Homo sapiens	219-223
25975581-6	2015	Isoacteoside significantly suppressed the production and mRNA expression of proinflammatory cytokines including IL-1beta, IL-6, IL-8 and TNF-alpha in PMACI-stimulated HMC-1 cells without cytotoxicity.	isoacteoside	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
25751776-5	2015	There were significant differences in gender, age, fever days, white blood cell count, C-reactive protein and blood glucose concentration and IL-8 levels among genotypes of IL-8-251A/T in EV71-infected patients, but no significant differences in alanine or aspartate aminotransferase, creatine kinase-myocardial isozyme and cerebrospinal fluid in patients with EV71 encephalitis.	Glucose	116-123	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
25816245-4	2015	HNPs induce IL-8 in lung epithelial cells and monocytes through the P2Y6 signaling pathway.	hnps	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
25816245-8	2015	The non-selective P2 receptor antagonists, suramin and pyridoxal phosphate-6-azo (benzene-2,4-disulfonic acid) tetrasodium salt hydrate (PPADS), significantly blocked the HNP-1-induced expression of IL-8 in the Caco-2 cells.	Suramin	43-50	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
25816245-8	2015	The non-selective P2 receptor antagonists, suramin and pyridoxal phosphate-6-azo (benzene-2,4-disulfonic acid) tetrasodium salt hydrate (PPADS), significantly blocked the HNP-1-induced expression of IL-8 in the Caco-2 cells.	pyridoxal phosphate-6-azo (benzene-2,4-disulfonic acid) tetrasodium salt hydrate	55-135	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
25816245-10	2015	In agreement with this finding, HNP-1 also significantly increased IL-8 production in the P2Y6-negative human colon cancer cell line, HT-29, and this increase was blocked by treatment with suramin and PPADS.	Suramin	189-196	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
25816245-12	2015	However, the HNP-1-induced production of IL-8 was suppressed by the ERK1/2 inhibitor, U0126, but not by the p38 MAPK inhibitor, SB203580.	U 0126	86-91	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
25910532-2	2015	The aim of this study was to determine whether the addition of ketamine reduces remifentanil-induced hyperalgesia; improves its analgesic effect; and alters interleukin 6 (IL-6), IL-8, and IL-10 levels.	Ketamine	63-71	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
25840641-13	2015	Blockage of STIM1 with BTP2 or SKF96265 abrogated ERK phosphorylation and IL-8 production induced by IL-9.	skf96265	31-39	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
25724683-7	2015	Ascorbic acid also enabled a greater suppression of IL8 secretion than when cells were treated with delta-Toc isoform alone.	Ascorbic Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
25715050-5	2015	rIFI16 caused dose/time-dependent upregulation of IL-6, IL-8, CCL2, CCL5, CCL20, ICAM1, VCAM1, and TLR4, while secretion of IL-6 and IL-8 was amplified with lipopolysaccharide synergy.	rifi16	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
25715050-5	2015	rIFI16 caused dose/time-dependent upregulation of IL-6, IL-8, CCL2, CCL5, CCL20, ICAM1, VCAM1, and TLR4, while secretion of IL-6 and IL-8 was amplified with lipopolysaccharide synergy.	rifi16	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
26043409-1	2015	Dental caries preventive agents, such as sodium fluoride (NaF) and bamboo salt (BS), are known to cause cellular growth that is characterized by morphological and gene expression changes.	Sodium Fluoride	41-56	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
25556347-8	2015	Importantly, known suppressive effects of dexamethasone, a drug employed for the treatment of inflammatory bowel diseases, on leucocyte migration, IL8, IL6, and TNF-alpha production as well as CD86 surface expression by myeloid cells were observed in this model.	Dexamethasone	42-55	C-X-C motif chemokine ligand 8	Homo sapiens	147-150
25651187-6	2015	Ethyl acetate extract decreased intracellular reactive oxygen species and significantly suppressed COX-2, IL-8, and prostaglandin E2 production and neutrophil chemotaxis by suppressing the translocation of the p65 subunit.	ethyl acetate	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
25708117-10	2015	Intestinal epithelial cells represent a direct target of the action of olive oil phenols where they regulate IL-8 expression by transcriptional and posttranscriptional mechanisms.	Phenols	81-88	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
25735562-4	2015	Thapsigargin stimulation of breast cancer cells induces IL8 expression in an NFAT-dependent manner.	Thapsigargin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
25537341-6	2015	The concentration of interleukin-8 secreted from Calu-3 cells following stimulation with transforming growth factor-beta resulted in significantly lower level of interleukin-8 released from the cells pre-treated with clarithromycin (5.2 +- 0.5 ng.ml(-1) clarithromycin treated vs. 7.7 +- 0.8 ng.ml(-1) control, respectively).	Clarithromycin	217-231	C-X-C motif chemokine ligand 8	Homo sapiens	21-34
25537341-6	2015	The concentration of interleukin-8 secreted from Calu-3 cells following stimulation with transforming growth factor-beta resulted in significantly lower level of interleukin-8 released from the cells pre-treated with clarithromycin (5.2 +- 0.5 ng.ml(-1) clarithromycin treated vs. 7.7 +- 0.8 ng.ml(-1) control, respectively).	Clarithromycin	217-231	C-X-C motif chemokine ligand 8	Homo sapiens	162-175
25537341-6	2015	The concentration of interleukin-8 secreted from Calu-3 cells following stimulation with transforming growth factor-beta resulted in significantly lower level of interleukin-8 released from the cells pre-treated with clarithromycin (5.2 +- 0.5 ng.ml(-1) clarithromycin treated vs. 7.7 +- 0.8 ng.ml(-1) control, respectively).	Clarithromycin	254-268	C-X-C motif chemokine ligand 8	Homo sapiens	21-34
25537341-7	2015	CONCLUSIONS: Our data demonstrate that treatment with clarithromycin decreases the paracellular permeability of epithelial cells, mucus secretion and interleukin-8 release and therefore, inhaled clarithromycin holds potential as an anti-inflammatory therapy.	Clarithromycin	54-68	C-X-C motif chemokine ligand 8	Homo sapiens	150-163
25537341-7	2015	CONCLUSIONS: Our data demonstrate that treatment with clarithromycin decreases the paracellular permeability of epithelial cells, mucus secretion and interleukin-8 release and therefore, inhaled clarithromycin holds potential as an anti-inflammatory therapy.	Clarithromycin	195-209	C-X-C motif chemokine ligand 8	Homo sapiens	150-163
25950646-1	2015	The reaction of 1,2,4-triazole and NaF with M(ox) (M = transition-metal dication; ox = oxalate dianion) under hydrothermal conditions has led to the isolation of a variety of hybrid organic-inorganic coordination polymers.	Metals	66-71	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
26521440-6	2015	Kaempferol significantly decreased the release of histamine, IL-6, IL-8, IL-1beta and TNF-alpha of activated HMC-1 mast cells (P&lt;0.01).	kaempferol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
26020773-7	2015	The production of IL-6, IL-8 and MMP-3 by chondrocytes significantly decreased in chitosan-alginate beads compared to alginate beads.	Chitosan	82-90	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
26020773-7	2015	The production of IL-6, IL-8 and MMP-3 by chondrocytes significantly decreased in chitosan-alginate beads compared to alginate beads.	Alginates	91-99	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
25985190-3	2015	In A549 lung epithelial cells in vitro we show that inhibition of basal PP2A activity by okadaic acid (OA) releases restraint on MAPKs and thereby increases MAPK-mediated pro-asthmatic cytokines, including IL-6 and IL-8.	Okadaic Acid	89-101	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
25389358-10	2015	CpdA, similarly to prednisolone, down-regulated endogenous and TNF-alpha-induced IL-6, IL-8, MMP-1 and MMP-3 protein secretion.	CPDA	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
25389358-11	2015	The dissociative effect of CpdA was confirmed using chondrocytes with no induction of leptin secretion, but with a significant decrease in IL-6, IL-8, MMP-1 and MMP-3 protein secretion.	CPDA	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
25964092-8	2015	Furthermore, ACh stimulation increased the production of IL-8 and time-dependently induced the activation of EGFR, PI3K, and AKT through M3R.	Acetylcholine	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
25964092-11	2015	ACh-induced activation of EGFR/PI3K/AKT pathway and subsequent IL-8 upregulation may be one of the important mechanisms of M3R function.	Acetylcholine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
25959257-7	2015	One component, 6-methyl-3,5-heptadien-2-one (MHDO), inhibited fMLF- and interleukin 8 (IL-8)-stimulated Ca(2+) flux, fMLF-induced chemotaxis, and PMA-induced ROS production in human neutrophils.	6-METHYL-3,5-HEPTADIEN-2-ONE	15-43	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
25959257-7	2015	One component, 6-methyl-3,5-heptadien-2-one (MHDO), inhibited fMLF- and interleukin 8 (IL-8)-stimulated Ca(2+) flux, fMLF-induced chemotaxis, and PMA-induced ROS production in human neutrophils.	mhdo	45-49	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
25959257-7	2015	One component, 6-methyl-3,5-heptadien-2-one (MHDO), inhibited fMLF- and interleukin 8 (IL-8)-stimulated Ca(2+) flux, fMLF-induced chemotaxis, and PMA-induced ROS production in human neutrophils.	Tetradecanoylphorbol Acetate	146-149	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
25959257-7	2015	One component, 6-methyl-3,5-heptadien-2-one (MHDO), inhibited fMLF- and interleukin 8 (IL-8)-stimulated Ca(2+) flux, fMLF-induced chemotaxis, and PMA-induced ROS production in human neutrophils.	Reactive Oxygen Species	158-161	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
25950646-1	2015	The reaction of 1,2,4-triazole and NaF with M(ox) (M = transition-metal dication; ox = oxalate dianion) under hydrothermal conditions has led to the isolation of a variety of hybrid organic-inorganic coordination polymers.	oxalate dianion	87-102	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
25950646-1	2015	The reaction of 1,2,4-triazole and NaF with M(ox) (M = transition-metal dication; ox = oxalate dianion) under hydrothermal conditions has led to the isolation of a variety of hybrid organic-inorganic coordination polymers.	Polymers	213-221	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
25985190-3	2015	In A549 lung epithelial cells in vitro we show that inhibition of basal PP2A activity by okadaic acid (OA) releases restraint on MAPKs and thereby increases MAPK-mediated pro-asthmatic cytokines, including IL-6 and IL-8.	Okadaic Acid	103-105	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
25725371-4	2015	Here, we demonstrate that human skin MCs display substantial susceptibility to RA by which they are instructed to increase pro-inflammatory mediators (IL-1beta, IL-8, TNF-alpha) but not histamine release.	Tretinoin	79-81	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
25903726-3	2015	In unstimulated cells, ketamine also increased IL-8 production and mRNA expression.	Ketamine	23-31	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
25961885-0	2015	In-vitro suppression of IL-6 and IL-8 release from human pulmonary epithelial cells by non-anticoagulant fraction of enoxaparin.	Enoxaparin	117-127	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
25961885-3	2015	Our study indicated that enoxaparin inhibits the release of IL-6 and IL-8 from A549 pulmonary epithelial cells.	Enoxaparin	25-35	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
25961885-13	2015	RESULTS: Enoxaparin (60 mug/mL) inhibited the release of IL-6 and IL-8 by &gt;30%.	Enoxaparin	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
25943109-11	2015	Additionally, LPS pre-incubation: 1) reduced dexamethasone"s capacity to inhibit FBS-induced IL-6, CXCL8 and RANTES, 2) reduced dexamethasone-induced GRalpha nuclear translocation (only in NM fibroblasts), 3) did not alter GRalpha/GRbeta expression, 4) decreased GILZ expression, and 5) did not affect dexamethasone"s capacity to induce MKP-1 and GILZ expression.	Dexamethasone	45-58	C-X-C motif chemokine ligand 8	Homo sapiens	99-104
25704613-10	2015	In EA.hy926 cells, DLC significantly inhibited the histamine- and LPS- induced IL-6 and IL-8 production and P-selectin and intercellular cell adhesion molecule-1 (ICAM-1) expression.	Histamine	51-60	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
25943109-12	2015	MKP-1 knockdown reduced dexamethasone"s capacity to suppress FBS-induced CXCL8 release.	Dexamethasone	24-37	C-X-C motif chemokine ligand 8	Homo sapiens	73-78
25746333-9	2015	We also found that lower viral replication after LiCl treatment was associated with the reduced mRNA levels of pro-inflammatory IL-8, IL-6, IL-1 beta, tumor necrosis factor alpha and decreased NF-kappaB nuclear translocation.	Lithium Chloride	49-53	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
25713319-1	2015	Asthma is characterized by airway inflammation and remodeling and CXCL8 is a CXC chemokine that drives steroid-resistant neutrophilic airway inflammation.	Steroids	103-110	C-X-C motif chemokine ligand 8	Homo sapiens	66-71
25591042-11	2015	Furthermore, the inhibitory effect of TGF-beta1 on 3"-5"-cyclic adenosine monophosphate-stimulated alveolar epithelial fluid transport required the presence of IL-8/cytokine-induced neutrophil chemoattractant-1 (n = 12 in each group).	3"-5"-cyclic adenosine monophosphate	51-87	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
25192219-10	2015	Supernatants from CS-treated neutrophils significantly increased the release of CXCL8 in normal human bronchial epithelial cells.	Cesium	18-20	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
25296132-8	2015	When cAMP was increased, there was a concomitant increase in MKP-1 levels and significant inhibition of TNF-alpha-induced CXCL8 (IL-8).	Cyclic AMP	5-9	C-X-C motif chemokine ligand 8	Homo sapiens	122-127
25296132-8	2015	When cAMP was increased, there was a concomitant increase in MKP-1 levels and significant inhibition of TNF-alpha-induced CXCL8 (IL-8).	Cyclic AMP	5-9	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
25791477-0	2015	Anticancer drug bortezomib increases interleukin-8 expression in human monocytes.	Bortezomib	16-26	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
25791477-4	2015	Since monocytes and macrophages are major producers of IL-8, the goal of this study was to test the hypothesis that BZ increases the IL-8 expression in human monocytes and macrophages.	Bortezomib	116-118	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
25791477-4	2015	Since monocytes and macrophages are major producers of IL-8, the goal of this study was to test the hypothesis that BZ increases the IL-8 expression in human monocytes and macrophages.	Bortezomib	116-118	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
25791477-5	2015	Here, we show that BZ dramatically increases the IL-8 expression in lipopolysaccharide (LPS)-stimulated U937 macrophages as well as in unstimulated U937 monocytes and peripheral blood mononuclear cells, while it inhibits expression of IL-6, IL-1 and tumor necrosis factor-alpha.	Bortezomib	19-21	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
25791477-6	2015	In addition, our results show that the underlying mechanisms involve p38 mitogen-activated protein kinase, which is required for the BZ-induced IL-8 expression.	Bortezomib	133-135	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
25791477-7	2015	Together, these data suggest that the BZ-increased IL-8 expression in monocytes and macrophages may represent one of the mechanisms responsible for the BZ resistance and indicate that targeting the p38-mediated IL-8 expression could enhance the BZ effectiveness in cancer treatment.	Bortezomib	38-40	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
25791477-7	2015	Together, these data suggest that the BZ-increased IL-8 expression in monocytes and macrophages may represent one of the mechanisms responsible for the BZ resistance and indicate that targeting the p38-mediated IL-8 expression could enhance the BZ effectiveness in cancer treatment.	Bortezomib	38-40	C-X-C motif chemokine ligand 8	Homo sapiens	211-215
25791477-7	2015	Together, these data suggest that the BZ-increased IL-8 expression in monocytes and macrophages may represent one of the mechanisms responsible for the BZ resistance and indicate that targeting the p38-mediated IL-8 expression could enhance the BZ effectiveness in cancer treatment.	Bortezomib	152-154	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
25791477-7	2015	Together, these data suggest that the BZ-increased IL-8 expression in monocytes and macrophages may represent one of the mechanisms responsible for the BZ resistance and indicate that targeting the p38-mediated IL-8 expression could enhance the BZ effectiveness in cancer treatment.	Bortezomib	152-154	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
25358442-7	2015	RESULTS: Dexamethasone reduced LPS-induced TNFalpha, IL-6 and CXCL-8 in all groups, but maximum inhibition was significantly reduced for GINA3/4 compared with GINA2 and GINA1 (P &lt; 0.01).	lps	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	62-68
25358442-7	2015	RESULTS: Dexamethasone reduced LPS-induced TNFalpha, IL-6 and CXCL-8 in all groups, but maximum inhibition was significantly reduced for GINA3/4 compared with GINA2 and GINA1 (P &lt; 0.01).	Dexamethasone	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	62-68
26314120-5	2015	The existence of influencing substance (e. g. NaCl, NaF, Na2SO4, CaCl2 and turbidity) would inhibit the removal of Cr(VI) ions, and promote the removal of total Cr to some extent.	Chromium	115-117	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
25813285-9	2015	Unfractionated heparin and LMWHs attenuated the TNF-alpha-mediated induction of CXCL8 and enhanced CXCL5, CCL2, and CCL5.	Heparin	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
25640157-14	2015	In vitro, it modulated the IL-8 response to infection in a vitamin D concentration-dependent manner.	Vitamin D	59-68	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
25813285-9	2015	Unfractionated heparin and LMWHs attenuated the TNF-alpha-mediated induction of CXCL8 and enhanced CXCL5, CCL2, and CCL5.	Heparin, Low-Molecular-Weight	27-32	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
25813285-10	2015	The stimulating effect of thrombin on CXCL8 could be inhibited by heparin, whereas heparin had no impact on thrombin-induced CXCL1 and CCL2.	Heparin	66-73	C-X-C motif chemokine ligand 8	Homo sapiens	38-43
26314120-5	2015	The existence of influencing substance (e. g. NaCl, NaF, Na2SO4, CaCl2 and turbidity) would inhibit the removal of Cr(VI) ions, and promote the removal of total Cr to some extent.	Chromium	161-163	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
25822013-12	2015	Furthermore, LF82 inhibited mucin gene expression (MUC2 and MUC5AC) in T84 cells while increasing the chemotactic IL-8 expression, both in a DPI-sensitive manner.	diphenyleneiodonium	141-144	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
25748730-5	2015	Paeoniflorin reduced ConA-induced IL-8 mRNA expression and IL-8 release by 57.9% and 52.8%, respectively, and also decreased ConA-stimulated phosphorylation of ERK1/2 and Akt, suggesting paeoniflorin inhibits IL-8 expression and release by inhibiting the ERK1/2 and Akt pathways.	peoniflorin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
25748730-0	2015	Paeoniflorin diminishes ConA-induced IL-8 production in primary human hepatic sinusoidal endothelial cells in the involvement of ERK1/2 and Akt phosphorylation.	peoniflorin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
25748730-6	2015	Combining paeoniflorin with U0126 or LY294002 at low doses showed supra-additive inhibition of not only phospho-ERK1/2 and phospho-Akt by 46.4% and 35.0%, but also IL-8 release by 42.4% and 36.1% and IL-8 mRNA expression by 43.5% and 31.8%, respectively.	peoniflorin	10-22	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
25748730-3	2015	We examined the effects and underlying mechanisms of paeoniflorin on IL-8 production in primary human hepatic sinusoidal endothelial cells (HHSECs).	peoniflorin	53-65	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
25748730-5	2015	Paeoniflorin reduced ConA-induced IL-8 mRNA expression and IL-8 release by 57.9% and 52.8%, respectively, and also decreased ConA-stimulated phosphorylation of ERK1/2 and Akt, suggesting paeoniflorin inhibits IL-8 expression and release by inhibiting the ERK1/2 and Akt pathways.	peoniflorin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
25748730-6	2015	Combining paeoniflorin with U0126 or LY294002 at low doses showed supra-additive inhibition of not only phospho-ERK1/2 and phospho-Akt by 46.4% and 35.0%, but also IL-8 release by 42.4% and 36.1% and IL-8 mRNA expression by 43.5% and 31.8%, respectively.	peoniflorin	10-22	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
25748730-5	2015	Paeoniflorin reduced ConA-induced IL-8 mRNA expression and IL-8 release by 57.9% and 52.8%, respectively, and also decreased ConA-stimulated phosphorylation of ERK1/2 and Akt, suggesting paeoniflorin inhibits IL-8 expression and release by inhibiting the ERK1/2 and Akt pathways.	peoniflorin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
25748730-6	2015	Combining paeoniflorin with U0126 or LY294002 at low doses showed supra-additive inhibition of not only phospho-ERK1/2 and phospho-Akt by 46.4% and 35.0%, but also IL-8 release by 42.4% and 36.1% and IL-8 mRNA expression by 43.5% and 31.8%, respectively.	U 0126	28-33	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
25748730-6	2015	Combining paeoniflorin with U0126 or LY294002 at low doses showed supra-additive inhibition of not only phospho-ERK1/2 and phospho-Akt by 46.4% and 35.0%, but also IL-8 release by 42.4% and 36.1% and IL-8 mRNA expression by 43.5% and 31.8%, respectively.	U 0126	28-33	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
26191223-6	2015	PE significantly inhibited poly (I:C)-induced expression of crucial psoriatic cytokines, such as IL-6, IL-8, CCL20 and TNF-alpha, via down-regulation of NF-kappaB signaling pathway in human keratinocytes.	pe	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
25748730-6	2015	Combining paeoniflorin with U0126 or LY294002 at low doses showed supra-additive inhibition of not only phospho-ERK1/2 and phospho-Akt by 46.4% and 35.0%, but also IL-8 release by 42.4% and 36.1% and IL-8 mRNA expression by 43.5% and 31.8%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
26191223-6	2015	PE significantly inhibited poly (I:C)-induced expression of crucial psoriatic cytokines, such as IL-6, IL-8, CCL20 and TNF-alpha, via down-regulation of NF-kappaB signaling pathway in human keratinocytes.	Poly I-C	27-37	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
25748730-6	2015	Combining paeoniflorin with U0126 or LY294002 at low doses showed supra-additive inhibition of not only phospho-ERK1/2 and phospho-Akt by 46.4% and 35.0%, but also IL-8 release by 42.4% and 36.1% and IL-8 mRNA expression by 43.5% and 31.8%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
25748730-7	2015	In conclusion, paeoniflorin most likely contributes to the therapy for liver disease by exerting anti-inflammatory effects on HHSECs through blocking IL-8 secretion via downregulation of ERK1/2 and Akt phosphorylation.	peoniflorin	15-27	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
26505033-2	2015	Hollow silica microsphere-containing acrylate resin-based dental restoration materials were prepared by using hollow silica microspheres as NaF reservoirs.	Silicon Dioxide	7-13	C-X-C motif chemokine ligand 8	Homo sapiens	140-143
25458910-0	2015	Randomized trial to evaluate azithromycin"s effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis.	Azithromycin	29-41	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
25458910-3	2015	OBJECTIVES: We sought to investigate whether azithromycin treatment during RSV bronchiolitis reduces serum and nasal lavage IL-8 levels and the occurrence of postbronchiolitis recurrent wheezing.	Azithromycin	45-57	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
25458910-7	2015	RESULTS: Compared with placebo, azithromycin treatment did not reduce serum IL-8 levels at day 8 (P = .6) but resulted in a greater decrease in nasal lavage fluid IL-8 levels by day 15 (P = .03).	Azithromycin	32-44	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
25458910-10	2015	CONCLUSION: In this proof-of-concept study azithromycin treatment during RSV bronchiolitis reduced upper airway IL-8 levels, prolonged the time to the third wheezing episode, and reduced overall respiratory morbidity over the subsequent year.	Azithromycin	43-55	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
25087735-7	2015	While free ODN and PSA-TMC nanoparticles coated with scrambled ODNs did not have substantial impacts on the inflammatory response, the decoy ODN-coated PSA-TMC nanoparticles were able to reduce the secretion of interleukin-6 and interleukin-8, pro-inflammatory mediators of CF, by the epithelial cells, particularly at longer time points.	trimethylchlorosilane	156-159	C-X-C motif chemokine ligand 8	Homo sapiens	229-242
26505033-2	2015	Hollow silica microsphere-containing acrylate resin-based dental restoration materials were prepared by using hollow silica microspheres as NaF reservoirs.	acrylate resin	37-51	C-X-C motif chemokine ligand 8	Homo sapiens	140-143
25736418-5	2015	AZD5069 was shown to inhibit binding of radiolabeled CXCL8 to human CXCR2 with a pIC50 value of 9.1.	N-(2-(2,3-difluoro-6-benzylthio)-6-(3,4-dihydroxybutan-2-yloxy)pyrimidin-4-yl)azetidine-1-sulfonamide	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	53-58
25919031-9	2014	These changes were at least partly ensured by the increased concentration of MCP-1 and IL-8 at 5% O2.	Oxygen	98-100	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
25987216-6	2015	In asthmatic children, we found that the serum levels of several polychlorinated biphenyl (PCB) congener sub-types were significantly positively correlated with interleukin (IL)-8 mRNA expression, whereas in a sub-group of children who displayed positive immunoglobulin E (IgE) responses to milk or egg proteins IL-22 mRNA expression was demonstrated to be useful for detecting the adverse health effects of environmental pollutants, particularly PCB congeners.	Polychlorinated Biphenyls	65-89	C-X-C motif chemokine ligand 8	Homo sapiens	161-179
25987216-6	2015	In asthmatic children, we found that the serum levels of several polychlorinated biphenyl (PCB) congener sub-types were significantly positively correlated with interleukin (IL)-8 mRNA expression, whereas in a sub-group of children who displayed positive immunoglobulin E (IgE) responses to milk or egg proteins IL-22 mRNA expression was demonstrated to be useful for detecting the adverse health effects of environmental pollutants, particularly PCB congeners.	Polychlorinated Biphenyls	91-94	C-X-C motif chemokine ligand 8	Homo sapiens	161-179
25871388-5	2015	The effects of IL-8 on gefitinib-induced apoptosis, stemness, and in vivo tumorigenicity were investigated using established cell lines.	Gefitinib	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
25871388-6	2015	We identified IL-8 was up-regulated in gefitinib-resistant cells, and high plasma IL-8 level was correlated with shorter progression-free-survival time.	Gefitinib	39-48	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
25871388-7	2015	IL-8 overexpression suppressed gefitinib-induced apoptosis in gefitinib-sensitive cells.	Gefitinib	31-40	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
25871388-7	2015	IL-8 overexpression suppressed gefitinib-induced apoptosis in gefitinib-sensitive cells.	Gefitinib	62-71	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
25871388-8	2015	By contrast, suppression of IL-8 enhanced gefitinib-induced cell death in gefitinib-resistant cells.	Gefitinib	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
25871388-8	2015	By contrast, suppression of IL-8 enhanced gefitinib-induced cell death in gefitinib-resistant cells.	Gefitinib	74-83	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
25871388-10	2015	Consistently, knockdown of IL-8 leads to loss of stem cell-like characteristics in gefitinib-resistant cells.	Gefitinib	83-92	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
25987216-7	2015	In conclusion, the mRNA expression levels of IL-8 and IL-22 can be used to detect children who are at particular risk of adverse health events caused by environmental pollutants, especially PCBs.	Polychlorinated Biphenyls	190-194	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
25995631-0	2015	Oxidative stress by layered double hydroxide nanoparticles via an SFK-JNK and p38-NF-kappaB signaling pathway mediates induction of interleukin-6 and interleukin-8 in human lung epithelial cells.	double	28-34	C-X-C motif chemokine ligand 8	Homo sapiens	150-163
25995631-0	2015	Oxidative stress by layered double hydroxide nanoparticles via an SFK-JNK and p38-NF-kappaB signaling pathway mediates induction of interleukin-6 and interleukin-8 in human lung epithelial cells.	hydroxide ion	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	150-163
25860871-9	2015	These findings suggest that PGG and PA may block or reduce the entry of the viruses into the cells to protect the cells from the virus destruction and abate virus replication, which may play an important role in interfering with expressions of rhinovirus receptors (intercellular adhesion molecule-1 and low-density lipoprotein receptor), inflammatory cytokines (interleukin (IL)-6, IL-8, tumor necrosis factor, interferon beta, and IL-1beta), and Toll-like receptor, which resulted in diminishing symptoms induced by HRV.	pgg	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	383-387
25827911-1	2015	Utilizing a novel 8-silyloxyquinoline scaffold, we demonstrate the ability to synthesize fluorogenic probes for the sensitive and selective detection of inorganic fluoride (NaF) in aqueous samples.	8-silyloxyquinoline	18-37	C-X-C motif chemokine ligand 8	Homo sapiens	173-176
25827911-1	2015	Utilizing a novel 8-silyloxyquinoline scaffold, we demonstrate the ability to synthesize fluorogenic probes for the sensitive and selective detection of inorganic fluoride (NaF) in aqueous samples.	inorganic fluoride	153-171	C-X-C motif chemokine ligand 8	Homo sapiens	173-176
25827911-4	2015	We demonstrate the ability to rationally tune the fluorescence and physical properties of the 8-silyloxyquinoline scaffold, producing a red-shifted fluoride probe (4) capable of detecting 50 muM (0.95 ppm) NaF in aqueous samples using a straightforward test-strip-based assay format.	8-silyloxyquinoline	94-113	C-X-C motif chemokine ligand 8	Homo sapiens	206-209
25827911-4	2015	We demonstrate the ability to rationally tune the fluorescence and physical properties of the 8-silyloxyquinoline scaffold, producing a red-shifted fluoride probe (4) capable of detecting 50 muM (0.95 ppm) NaF in aqueous samples using a straightforward test-strip-based assay format.	Fluorides	148-156	C-X-C motif chemokine ligand 8	Homo sapiens	206-209
25767074-3	2015	Cucurbitacin B significantly inhibited imiquimod-induced expression of crucial psoriatic cytokines, such as IL-8 and CCL20, via down-regulation of NF-kappaB and STAT3 signaling pathway in human keratinocytes.	cucurbitacin B	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
25767074-3	2015	Cucurbitacin B significantly inhibited imiquimod-induced expression of crucial psoriatic cytokines, such as IL-8 and CCL20, via down-regulation of NF-kappaB and STAT3 signaling pathway in human keratinocytes.	Imiquimod	39-48	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
25915936-8	2015	RESULTS: Human rSSB stimulated IL-8 production from normal human neutrophils and HL-60 (RA) cells in a time- and dose-dependent manner.	rssb	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
25915936-9	2015	This IL-8-stimulated activity was blocked by chloroquine and NH4Cl, indicating that endosomal acidification is important for this effect.	Chloroquine	45-56	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
25915936-9	2015	This IL-8-stimulated activity was blocked by chloroquine and NH4Cl, indicating that endosomal acidification is important for this effect.	Ammonium Chloride	61-66	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
25915936-10	2015	We found rSSB activated both MAPK pathway and nuclear factor-kappaB signaling to transcribe the IL-8 gene expression of cells.	rssb	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
25915936-11	2015	Furthermore, tumor necrosis factor-alpha exerted an additive effect and rSSB-anti-SSB immune complex exhibited a synergistic effect on rSSB-induced IL-8 production.	rssb	72-76	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
25637608-3	2015	We previously reported that the beta2-agonist fenoterol, direct activation of protein kinase A (PKA), and exchange factor directly activated by cAMP decrease cigarette smoke extract (CSE)-induced release of neutrophil attractant interleukin-8 (IL-8) from human airway smooth muscle (ASM) cells.	Fenoterol	46-55	C-X-C motif chemokine ligand 8	Homo sapiens	229-242
25637608-3	2015	We previously reported that the beta2-agonist fenoterol, direct activation of protein kinase A (PKA), and exchange factor directly activated by cAMP decrease cigarette smoke extract (CSE)-induced release of neutrophil attractant interleukin-8 (IL-8) from human airway smooth muscle (ASM) cells.	Cyclic AMP	144-148	C-X-C motif chemokine ligand 8	Homo sapiens	229-242
25637608-3	2015	We previously reported that the beta2-agonist fenoterol, direct activation of protein kinase A (PKA), and exchange factor directly activated by cAMP decrease cigarette smoke extract (CSE)-induced release of neutrophil attractant interleukin-8 (IL-8) from human airway smooth muscle (ASM) cells.	Cyclic AMP	144-148	C-X-C motif chemokine ligand 8	Homo sapiens	244-248
25931819-7	2015	Additionally, this paper evidenced the dimer had the basic structural unit of Cu(2+)-FS in water, theoretically simulated the formation of Cu(2+)-FS nanoparticles, and identified that Cu(2+)-FS activity in decreasing glycoprotein IIb/IIIa, P-selectin, and IL-8 was responsible for the antithrombotic action.	cu(2+)-fs	78-87	C-X-C motif chemokine ligand 8	Homo sapiens	256-260
25931819-7	2015	Additionally, this paper evidenced the dimer had the basic structural unit of Cu(2+)-FS in water, theoretically simulated the formation of Cu(2+)-FS nanoparticles, and identified that Cu(2+)-FS activity in decreasing glycoprotein IIb/IIIa, P-selectin, and IL-8 was responsible for the antithrombotic action.	Water	91-96	C-X-C motif chemokine ligand 8	Homo sapiens	256-260
25931819-7	2015	Additionally, this paper evidenced the dimer had the basic structural unit of Cu(2+)-FS in water, theoretically simulated the formation of Cu(2+)-FS nanoparticles, and identified that Cu(2+)-FS activity in decreasing glycoprotein IIb/IIIa, P-selectin, and IL-8 was responsible for the antithrombotic action.	cu(2+)-fs	139-148	C-X-C motif chemokine ligand 8	Homo sapiens	256-260
25931819-7	2015	Additionally, this paper evidenced the dimer had the basic structural unit of Cu(2+)-FS in water, theoretically simulated the formation of Cu(2+)-FS nanoparticles, and identified that Cu(2+)-FS activity in decreasing glycoprotein IIb/IIIa, P-selectin, and IL-8 was responsible for the antithrombotic action.	cu(2+)-fs	139-148	C-X-C motif chemokine ligand 8	Homo sapiens	256-260
25926797-4	2015	We found that resveratrol reduced IL-6, IL-8, and MCP-1 levels in a concentration-dependent manner in adipocytes under inflammatory conditions.	Resveratrol	14-25	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
25889494-5	2015	RESULTS: AICAR and metformin markedly reduced the IL-8 and GROalpha production induced by TNF-alpha.	Metformin	19-28	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
25860871-9	2015	These findings suggest that PGG and PA may block or reduce the entry of the viruses into the cells to protect the cells from the virus destruction and abate virus replication, which may play an important role in interfering with expressions of rhinovirus receptors (intercellular adhesion molecule-1 and low-density lipoprotein receptor), inflammatory cytokines (interleukin (IL)-6, IL-8, tumor necrosis factor, interferon beta, and IL-1beta), and Toll-like receptor, which resulted in diminishing symptoms induced by HRV.	paeonol	36-38	C-X-C motif chemokine ligand 8	Homo sapiens	383-387
25856395-5	2015	Curcumin pre-treatment also abrogated the gp120-mediated upregulation of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin (IL)-6, which mediate barrier disruption, as well as the chemokines IL-8, RANTES and interferon gamma-induced protein-10 (IP-10), which are capable of recruiting HIV target cells to the FGT.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
25937780-9	2015	Higher mRNA and supernate secretion levels of IL-1beta, IL-6 and IL-8 were detected in SPC-A1 after being cocultured with TAMs.	tams	122-126	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
25683465-12	2015	Furthermore, in epithelial cells from resection material of patients with Crohn"s disease and ulcerative colitis, high expression of CXCL-8 was associated with a reduced choline acetyl transferase expression, suggesting an aberrant epithelial production of ACh in inflammatory context.	Acetylcholine	257-260	C-X-C motif chemokine ligand 8	Homo sapiens	133-139
25646974-5	2015	When combining all four study groups, statistically significant positive correlations included uPCR with urine IL-8, urine MCP-1, urine IP-10, and serum IP-10 and uACR with urine IL-8, urine B2M, serum IP-10, and serum B2M.	uacr	163-167	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
25608533-9	2015	EPS-stimulated mRNA expression levels of MYH7, IL-6, and IL-8 correlated negatively with subjects" HbA1c and/or fasting plasma glucose, suggesting an effect linked to the diabetic phenotype.	eps	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
25608533-9	2015	EPS-stimulated mRNA expression levels of MYH7, IL-6, and IL-8 correlated negatively with subjects" HbA1c and/or fasting plasma glucose, suggesting an effect linked to the diabetic phenotype.	Glucose	127-134	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
25394884-5	2015	RESULTS: Increasing concentrations of glucose significantly increased trophoblast secretion of the inflammatory cytokines/chemokines: IL-1beta, IL-6, IL-8, GRO-alpha, RANTES, and G-CSF; significantly increased trophoblast secretion of the anti-angiogenic factors sFlt-1 and sEndoglin; and significantly decreased trophoblast migration.	Glucose	38-45	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
25937780-13	2015	CONCLUSIONS: These findings demonstrated that TAMs may enhance IL-1beta, IL-6 and IL-8 expressions via TLRs signaling pathway.	tams	46-50	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
25515776-9	2015	The production of IL6 and IL8 was also suppressed by p38 inhibitor SB203580.	SB 203580	67-75	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
25575297-6	2015	A selective Ca(2+) chelator, BAPTA-AM, prevented TRP channel agonists-mediated IL-6 and IL-8 induction.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
25515776-6	2015	Poly(dA:dT) induced the expression of pro-inflammatory cytokine genes including IFN-beta, TNF-alpha, IL-6 and IL-8 as well, whereas the pro-inflammatory cytokine production was suppressed by RIG-I siRNA, but not by AIM2 siRNA.	poly	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
25690135-16	2015	ACN extract and M3G significantly attenuated TNF-alpha-stimulated low-grade leukocyte adhesion, expression of adhesion molecules E-selectin, VCAM-1 and ICAM-1 and cytokine expression and secretion (IL-8 and IL-6) as well as NF-kappaB mRNA expression.	Anthocyanins	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	198-202
25515776-6	2015	Poly(dA:dT) induced the expression of pro-inflammatory cytokine genes including IFN-beta, TNF-alpha, IL-6 and IL-8 as well, whereas the pro-inflammatory cytokine production was suppressed by RIG-I siRNA, but not by AIM2 siRNA.	amsonic acid	5-7	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
25515776-6	2015	Poly(dA:dT) induced the expression of pro-inflammatory cytokine genes including IFN-beta, TNF-alpha, IL-6 and IL-8 as well, whereas the pro-inflammatory cytokine production was suppressed by RIG-I siRNA, but not by AIM2 siRNA.	Thymidine	8-10	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
25611805-5	2015	Phlorizin also decreased the expression of UVB-induced pro-inflammatory cytokines, such as interleukin-1 beta (IL-1beta), interleukin-6 (IL-6) and interleukin-8 (IL-8) at the mRNA level.	Phlorhizin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	147-160
25611805-5	2015	Phlorizin also decreased the expression of UVB-induced pro-inflammatory cytokines, such as interleukin-1 beta (IL-1beta), interleukin-6 (IL-6) and interleukin-8 (IL-8) at the mRNA level.	Phlorhizin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
25708600-6	2015	RESULTS: Niclosamide reduced the secretion of IL-1beta, IL-6, IL-8, IL-17A and IFN-gamma from TNF-alpha-induced RA FLS in a dose-dependent manner.	Niclosamide	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
25532794-8	2015	Poly(I:C) induced activation of TLR-2 contributes to stronger cell responses to a TLR-2 agonist and regulation of these synergistic responses may take place at the mRNA level of IL-6 and IL-8.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
25519802-8	2015	DHMEQ significantly suppressed the production of both IL-8 and MCP-1 in IL-1beta-stimulated HCFs.	dehydroxymethylepoxyquinomicin	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
25519802-11	2015	CONCLUSIONS: The suppression of inflammatory chemokines IL-8 and MCP-1 and inhibition of the expression of ICAM-1 in cultured HCFs by DHMEQ indicates that DHMEQ may have a therapeutic potential for treating ICAM-1 and chemokine-mediated corneal inflammatory disorders.	dehydroxymethylepoxyquinomicin	155-160	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
25625672-1	2015	OBJECTIVES: To evaluate the anti-erosive potential of solutions containing sodium fluoride (NaF, 225 ppm F) and different film-forming agents.	Sodium Fluoride	75-90	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
25659498-11	2015	AMPK activators AICAR, phenformin and A769662 significantly decreased IL-6 and IL-8 stimulated by LPS, flagellin and poly(I:C).	Phenformin	23-33	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
25872712-2	2015	Although both oxidative and endoplasmic reticulum (ER) stresses have been implicated in fluorosis, the signaling pathways and their roles in sodium fluoride (NaF)-induced apoptosis of Sertoli cells have been sparsely described.	Sodium Fluoride	141-156	C-X-C motif chemokine ligand 8	Homo sapiens	158-161
25872712-6	2015	In addition, NaF exposure facilitated the accumulation of ROS and increased nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in Sertoli cells.	Reactive Oxygen Species	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
25872712-7	2015	Treatment with NAC caused remarkable recovery from these NaF-induced responses.	Acetylcysteine	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
25872712-9	2015	NAC effectively blocked the activation of ER stress, suggesting that NaF-induced ROS is an early event that triggers ER stress.	Acetylcysteine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
25872712-9	2015	NAC effectively blocked the activation of ER stress, suggesting that NaF-induced ROS is an early event that triggers ER stress.	Reactive Oxygen Species	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
25872712-10	2015	Taken together, the results demonstrate that the ROS-mediated ER stress pathway is the crucial mechanistic event involved in NaF-induced apoptosis of Sertoli cells.	Reactive Oxygen Species	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	125-128
25675966-3	2015	The release of interleukin-8 (IL-8) from human epidermal keratinocytes stimulated by the addition of 100 mug ml(-1) beta-glucan of Saccharomyces cerevisiae was significantly inhibited by LCZ at the concentration of 10(-5) mol l(-1).	latoconazole	187-190	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
25675966-3	2015	The release of interleukin-8 (IL-8) from human epidermal keratinocytes stimulated by the addition of 100 mug ml(-1) beta-glucan of Saccharomyces cerevisiae was significantly inhibited by LCZ at the concentration of 10(-5) mol l(-1).	latoconazole	187-190	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
24854880-11	2015	Interestingly, small interfering RNA (siRNA) knock down of the TLR2 and ERK1/2 inhibitor, PD98059, abolished the effects of P. gingivalis LPS on the bone sialoprotein mRNA level, whereas siRNA knock down of the TLR2 and p38 MAPK inhibitor, SB203580, blocked the effect of P. gingivalis LPS on IL-8 in hPDLFs.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	90-97	C-X-C motif chemokine ligand 8	Homo sapiens	293-297
25604035-7	2015	RESULTS: PF4:heparin complexes caused release of the biomarker interleukin 8 in whole blood, and the level of response varied with the stoichiometric ratio of PF4 to heparin.	Heparin	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
25604035-7	2015	RESULTS: PF4:heparin complexes caused release of the biomarker interleukin 8 in whole blood, and the level of response varied with the stoichiometric ratio of PF4 to heparin.	Heparin	166-173	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
25595138-8	2015	Improvements in ACQ and/or AQLQ scores with atorvastatin and ICS were associated with decreases in G-CSF, IL-7, CCL2 and CXCL8.	acenaphthenequinone	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	121-126
25595138-8	2015	Improvements in ACQ and/or AQLQ scores with atorvastatin and ICS were associated with decreases in G-CSF, IL-7, CCL2 and CXCL8.	aqlq	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	121-126
25595138-8	2015	Improvements in ACQ and/or AQLQ scores with atorvastatin and ICS were associated with decreases in G-CSF, IL-7, CCL2 and CXCL8.	Atorvastatin	44-56	C-X-C motif chemokine ligand 8	Homo sapiens	121-126
25870718-3	2015	Control discs were removed before subjects rinsed with 0.1% chlorhexidine digluconate (CHX) or 0.2% sodium fluoride (NaF) for 1 minute.	Sodium Fluoride	100-115	C-X-C motif chemokine ligand 8	Homo sapiens	117-120
25756398-10	2015	CONCLUSIONS: Interleukin-8, sVEGFR-3, and SDF-1alpha were identified as predictors of sunitinib clinical outcome.	Sunitinib	86-95	C-X-C motif chemokine ligand 8	Homo sapiens	13-26
25695485-0	2015	IL8 polymorphisms and overall survival in pazopanib- or sunitinib-treated patients with renal cell carcinoma.	pazopanib	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
25695485-0	2015	IL8 polymorphisms and overall survival in pazopanib- or sunitinib-treated patients with renal cell carcinoma.	Sunitinib	56-65	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
25695485-4	2015	RESULTS: In study 1, four SNPs showed nominally significant association (P&lt;=0.05) with OS; two of these SNPs (rs1126647, rs4073) in IL8 were associated (P&lt;=0.05) with OS in study 2.	Osmium	90-92	C-X-C motif chemokine ligand 8	Homo sapiens	135-138
25695485-7	2015	CONCLUSIONS: Variant alleles of IL8 polymorphisms are associated with poorer survival outcomes in pazopanib- or sunitinib-treated patients with aRCC.	pazopanib	98-107	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
25695485-7	2015	CONCLUSIONS: Variant alleles of IL8 polymorphisms are associated with poorer survival outcomes in pazopanib- or sunitinib-treated patients with aRCC.	Sunitinib	112-121	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
25451977-5	2015	Both in human myometrium and amnion, OT-induced activation of the canonical NF-kappaB pathway upregulated key inflammatory labour-associated genes including IL-8, CCL5, IL-6 and COX-2.	Oxytocin	37-39	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
25695485-7	2015	CONCLUSIONS: Variant alleles of IL8 polymorphisms are associated with poorer survival outcomes in pazopanib- or sunitinib-treated patients with aRCC.	arcc	144-148	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
25660662-4	2015	The results show that production of IL-1beta, IL-6 and IL-8 was significantly higher in the group of methadone-maintained patients than in the healthy control group.	Methadone	101-110	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
25657098-3	2015	The experimental results prove that the NaF : Ln(3+) molar ratio influences significantly the growth process of the nanocrystals, i.e. a low NaF : Ln(3+) molar ratio results in hexagonal NaScF4 nanocrystals, while a high NaF : Ln(3+) molar ratio favors monoclinic Na3ScF6 nanocrystals.	nascf4	187-193	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
25657098-3	2015	The experimental results prove that the NaF : Ln(3+) molar ratio influences significantly the growth process of the nanocrystals, i.e. a low NaF : Ln(3+) molar ratio results in hexagonal NaScF4 nanocrystals, while a high NaF : Ln(3+) molar ratio favors monoclinic Na3ScF6 nanocrystals.	nascf4	187-193	C-X-C motif chemokine ligand 8	Homo sapiens	141-144
25657098-3	2015	The experimental results prove that the NaF : Ln(3+) molar ratio influences significantly the growth process of the nanocrystals, i.e. a low NaF : Ln(3+) molar ratio results in hexagonal NaScF4 nanocrystals, while a high NaF : Ln(3+) molar ratio favors monoclinic Na3ScF6 nanocrystals.	nascf4	187-193	C-X-C motif chemokine ligand 8	Homo sapiens	141-144
25657098-3	2015	The experimental results prove that the NaF : Ln(3+) molar ratio influences significantly the growth process of the nanocrystals, i.e. a low NaF : Ln(3+) molar ratio results in hexagonal NaScF4 nanocrystals, while a high NaF : Ln(3+) molar ratio favors monoclinic Na3ScF6 nanocrystals.	na3scf6	264-271	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
25657098-3	2015	The experimental results prove that the NaF : Ln(3+) molar ratio influences significantly the growth process of the nanocrystals, i.e. a low NaF : Ln(3+) molar ratio results in hexagonal NaScF4 nanocrystals, while a high NaF : Ln(3+) molar ratio favors monoclinic Na3ScF6 nanocrystals.	na3scf6	264-271	C-X-C motif chemokine ligand 8	Homo sapiens	141-144
25657098-3	2015	The experimental results prove that the NaF : Ln(3+) molar ratio influences significantly the growth process of the nanocrystals, i.e. a low NaF : Ln(3+) molar ratio results in hexagonal NaScF4 nanocrystals, while a high NaF : Ln(3+) molar ratio favors monoclinic Na3ScF6 nanocrystals.	na3scf6	264-271	C-X-C motif chemokine ligand 8	Homo sapiens	141-144
25888119-10	2015	In a univariate analysis IL6 and IL8 levels were associated with SAA&gt;6.4 mg/l (OR=1.74 and 1.46; 95% CI=1.00-3.03 and 1.06-2.01; p=0.051 and 0.02 respectively) and hsCRP&gt;3 mg/l in (OR=2.00 and 1.37; 95% CI=1.09-3.69 and 1.02-1.85; p=0.026 and 0.039 respectively).	hscrp	167-172	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
25660271-1	2015	We report the design and synthesis of an aquacarbonyl Ru(II) dication cis-[Ru(CO)2(H2O)4](2+) reagent for histidine (His)-selective metallation of interleukin (IL)-8 at site 33.	ru(ii)	54-60	C-X-C motif chemokine ligand 8	Homo sapiens	147-165
25660271-1	2015	We report the design and synthesis of an aquacarbonyl Ru(II) dication cis-[Ru(CO)2(H2O)4](2+) reagent for histidine (His)-selective metallation of interleukin (IL)-8 at site 33.	cis-[ru(co)2(h2o)4](2+) reagent	70-101	C-X-C motif chemokine ligand 8	Homo sapiens	147-165
25660271-1	2015	We report the design and synthesis of an aquacarbonyl Ru(II) dication cis-[Ru(CO)2(H2O)4](2+) reagent for histidine (His)-selective metallation of interleukin (IL)-8 at site 33.	Histidine	106-115	C-X-C motif chemokine ligand 8	Homo sapiens	147-165
25660271-1	2015	We report the design and synthesis of an aquacarbonyl Ru(II) dication cis-[Ru(CO)2(H2O)4](2+) reagent for histidine (His)-selective metallation of interleukin (IL)-8 at site 33.	Histidine	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	147-165
25646691-0	2015	Gemcitabine-induced CXCL8 expression counteracts its actions by inducing tumor neovascularization.	gemcitabine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	20-25
25646691-4	2015	We observed that gemcitabine enhanced selectively the expression of CXCL8 in human pancreatic cancer cells through ROS generation and NF-kappaB activation.	gemcitabine	17-28	C-X-C motif chemokine ligand 8	Homo sapiens	68-73
25646691-4	2015	We observed that gemcitabine enhanced selectively the expression of CXCL8 in human pancreatic cancer cells through ROS generation and NF-kappaB activation.	Reactive Oxygen Species	115-118	C-X-C motif chemokine ligand 8	Homo sapiens	68-73
25646691-6	2015	Gemcitabine also enhanced CXCL8 expression in pancreatic cancer cells in xenografted tumor tissues.	gemcitabine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	26-31
25646691-7	2015	Moreover, anti-CXCL8 antibody treatment in vivo attenuated tumor formation as well as intra-tumoral vascularity in nude mice, which were transplanted with Miapaca-2 cells and treated with gemcitabine.	gemcitabine	188-199	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
25646691-8	2015	Thus, gemcitabine-induced CXCL8 may counteract the drug through inducing neovascularization.	gemcitabine	6-17	C-X-C motif chemokine ligand 8	Homo sapiens	26-31
25595472-5	2015	The studied Ti-Bi alloys showed better corrosion resistance than pure Ti in both AS (artificial saliva) and ASFL (AS containing 0.2% NaF and 0.3% lactic acid) solutions.	Titanium	12-14	C-X-C motif chemokine ligand 8	Homo sapiens	133-136
25002707-2	2015	Most recent studies on glucose stabilities confirm that the sodium fluoride/potassium oxalate (NaF/KOx) tube is far from the gold standard.	Glucose	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
25002707-2	2015	Most recent studies on glucose stabilities confirm that the sodium fluoride/potassium oxalate (NaF/KOx) tube is far from the gold standard.	Sodium Fluoride	60-75	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
25002707-2	2015	Most recent studies on glucose stabilities confirm that the sodium fluoride/potassium oxalate (NaF/KOx) tube is far from the gold standard.	Oxalic Acid	76-93	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
25002707-4	2015	Greiner has introduced a glucose-specific tube (Glucomedics) containing NaF/KOx, citrate, and EDTA to minimise glycolysis.	Glucose	25-32	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
26016020-2	2015	An increase in the IL-6, IL-8, TNF-alpha and p53 genes expression in the concentration range of silver and titanium dioxide nanoparticles of 10-40 muk g/ml was found.	Silver	96-102	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
26016020-2	2015	An increase in the IL-6, IL-8, TNF-alpha and p53 genes expression in the concentration range of silver and titanium dioxide nanoparticles of 10-40 muk g/ml was found.	titanium dioxide	107-123	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
24806810-5	2015	RESULTS: P. gingivalis LPS induced cytokine/chemokine (IL-6, IL-8, MCP-1, and GRO) protein production in HGFs, and this effect was suppressed by azithromycin at all concentrations tested.	Azithromycin	145-157	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
25403159-4	2015	Sesaminol also inhibited the expression of IL-8 and IL-6 mRNA following CSE exposure.	sesaminol	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
25769104-6	2015	ADE extracts induced Nrf2 activity and IL-8 mRNA levels significantly more than Non-ADE.	Adenine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
24106166-4	2015	At a concentration of 0.1 muM, Pb(2+) induced IL-8 gene activation in gastric carcinoma AGS cells.	Lead	31-33	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
24106166-6	2015	Upregulation of the IL-8 gene was abrogated by the MEK inhibitor, PD98059, and partially suppressed by the epidermal growth factor receptor inhibitors, AG1478 and PD153035.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	66-73	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
24106166-6	2015	Upregulation of the IL-8 gene was abrogated by the MEK inhibitor, PD98059, and partially suppressed by the epidermal growth factor receptor inhibitors, AG1478 and PD153035.	RTKI cpd	152-158	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
24106166-6	2015	Upregulation of the IL-8 gene was abrogated by the MEK inhibitor, PD98059, and partially suppressed by the epidermal growth factor receptor inhibitors, AG1478 and PD153035.	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	163-171	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
24106166-7	2015	Furthermore, c-Jun protein expression was induced in cells treated with Pb(2+) , and overexpression of c-Jun enhanced Pb(2+) -induced IL-8 activation.	Lead	72-74	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
25454806-0	2015	Unfractionated heparin attenuates LPS-induced IL-8 secretion via PI3K/Akt/NF-kappaB signaling pathway in human endothelial cells.	Heparin	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
24106166-7	2015	Furthermore, c-Jun protein expression was induced in cells treated with Pb(2+) , and overexpression of c-Jun enhanced Pb(2+) -induced IL-8 activation.	Lead	118-120	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
25454806-4	2015	Pretreatment with UFH (0.1-1U/ml) significantly inhibited LPS (10mug/ml)-stimulated interleukin (IL)-6 and IL-8 production in HPMECs.	Heparin	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
25454806-6	2015	Inhibition studies by using wortmannin abrogated NF-kappaB-mediated IL-6 and IL-8 expression, suggesting the requirement of PI3K/Akt pathway.	Wortmannin	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
25590211-0	2015	Metformin reverts the secretion of CXCL8 induced by TNF-alpha in primary cultures of human thyroid cells: an additional indirect anti-tumor effect of the drug.	Metformin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	35-40
24766418-7	2015	Additionally, glutamine suppressed the production and mRNA expression of inflammatory cytokines including interleukin-1beta (IL-1beta), TNF-alpha, and IL-8.	Glutamine	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
24786562-13	2015	Changes in normalized IL-6 and IL-8 levels upon treatment with L-mimosine did not reach the level of significance (P &gt; 0.05), whilst treatment with IL-1, which served as positive control, increased IL-6 (P &lt; 0.05) and IL-8 levels (P &lt; 0.05).	Mimosine	63-73	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
25808165-10	2015	However, most of the metals including (V(+4), V(+5)), (Cr(+3), Cr(+6)), Zn, and Pb inhibited the production of both IL-6 and IL-8.	Chromium	55-57	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
25808165-10	2015	However, most of the metals including (V(+4), V(+5)), (Cr(+3), Cr(+6)), Zn, and Pb inhibited the production of both IL-6 and IL-8.	Chromium	63-65	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
25808165-10	2015	However, most of the metals including (V(+4), V(+5)), (Cr(+3), Cr(+6)), Zn, and Pb inhibited the production of both IL-6 and IL-8.	Zinc	72-74	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
25808165-10	2015	However, most of the metals including (V(+4), V(+5)), (Cr(+3), Cr(+6)), Zn, and Pb inhibited the production of both IL-6 and IL-8.	Lead	80-82	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
25590211-4	2015	OBJECTIVE: This study aimed to evaluate whether metformin inhibits the secretion of CXCL8 induced by Tumor-Necrosis-Factor-alpha (TNF-alpha) in primary cultures of normal and tumor human thyroid cells as well as in thyroid cancer cell lines.	Metformin	48-57	C-X-C motif chemokine ligand 8	Homo sapiens	84-89
25590211-7	2015	RESULTS: Metformin significantly and dose-dependently inhibited the TNF-alpha-induced CXCL8 secretion in both normal thyrocytes (ANOVA: F = 42.04; P &lt; .0001) and papillary thyroid cancer cells (ANOVA: F = 21.691; P &lt; .0001) but not in TPC-1 and BCPAP cell lines.	Metformin	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	86-91
25590211-8	2015	CONCLUSION: Metformin inhibits the TNF-alpha-induced CXCL8 secretion in primary cultures of normal thyroid cells and differentiated thyroid cancer cells at least of the most frequent poorly aggressive phenotype.	Metformin	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	53-58
25590211-10	2015	Thus, the here-reported inhibiting effect of metformin on TNF-alpha-induced CXCL8 secretion could be considered as a further indirect anticancer property of the drug.	Metformin	45-54	C-X-C motif chemokine ligand 8	Homo sapiens	76-81
25467970-0	2015	Epoxyeicosatrienoic acids attenuate cigarette smoke extract-induced interleukin-8 production in bronchial epithelial cells.	epoxyeicosatrienoic acids	0-25	C-X-C motif chemokine ligand 8	Homo sapiens	68-81
25538104-8	2015	Fexofenadine significantly inhibited the upregulated expression of IL-8 in HCT116 and COLO205 cells stimulated with TNF-alpha.	fexofenadine	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
25481370-0	2015	Lipoteichoic acid from Lactobacillus plantarum inhibits Pam2CSK4-induced IL-8 production in human intestinal epithelial cells.	lipoteichoic acid	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
25554564-0	2015	The atypical antipsychotic clozapine selectively inhibits interleukin 8 (IL-8)-induced neutrophil chemotaxis.	Clozapine	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	58-71
25554564-0	2015	The atypical antipsychotic clozapine selectively inhibits interleukin 8 (IL-8)-induced neutrophil chemotaxis.	Clozapine	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
25554564-3	2015	We found that clozapine, within the therapeutic concentration range, potently and selectively inhibits PMN chemotaxis induced by interleukin 8 (IL-8), a chemokine inducing neutrophil migration.	Clozapine	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	129-142
25554564-3	2015	We found that clozapine, within the therapeutic concentration range, potently and selectively inhibits PMN chemotaxis induced by interleukin 8 (IL-8), a chemokine inducing neutrophil migration.	Clozapine	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
25554564-3	2015	We found that clozapine, within the therapeutic concentration range, potently and selectively inhibits PMN chemotaxis induced by interleukin 8 (IL-8), a chemokine inducing neutrophil migration.	platensimycin	103-106	C-X-C motif chemokine ligand 8	Homo sapiens	129-142
25554564-3	2015	We found that clozapine, within the therapeutic concentration range, potently and selectively inhibits PMN chemotaxis induced by interleukin 8 (IL-8), a chemokine inducing neutrophil migration.	platensimycin	103-106	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
25554564-7	2015	An interference of clozapine with the autocrine release of leukotriene B4 (LTB4), a secondary chemoattractant secreted by neutrophils in response to the primary chemoattractant IL-8, was hypothesized.	Clozapine	19-28	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
25554564-7	2015	An interference of clozapine with the autocrine release of leukotriene B4 (LTB4), a secondary chemoattractant secreted by neutrophils in response to the primary chemoattractant IL-8, was hypothesized.	Leukotriene B4	59-73	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
25554564-8	2015	In agreement with this hypothesis, clozapine attenuated the IL-8-induced release of LTB4 in PMNs.	Clozapine	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
25554564-10	2015	Intriguingly MK-571, an inhibitor of the multi-drug resistance protein MRP4, playing a pivotal role in effluxing LTB4, completely blocked PMN chemotaxis induced by IL-8, but gave conflicting results when tested for its ability to reduce LTB4 release, increasing LTB4 efflux by itself but reducing the release when in combination with IL-8.	verlukast	13-19	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
25554564-10	2015	Intriguingly MK-571, an inhibitor of the multi-drug resistance protein MRP4, playing a pivotal role in effluxing LTB4, completely blocked PMN chemotaxis induced by IL-8, but gave conflicting results when tested for its ability to reduce LTB4 release, increasing LTB4 efflux by itself but reducing the release when in combination with IL-8.	verlukast	13-19	C-X-C motif chemokine ligand 8	Homo sapiens	334-338
25467970-4	2015	Treatment with 11,12-EET or 14,15-EET attenuated the CSE-induced release of interleukin (IL)-8 by inhibiting the phosphorylation of p38 mitogen-activated protein kinases (MAPKs).	11,12-epoxy-5,8,14-eicosatrienoic acid	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	76-94
25467970-4	2015	Treatment with 11,12-EET or 14,15-EET attenuated the CSE-induced release of interleukin (IL)-8 by inhibiting the phosphorylation of p38 mitogen-activated protein kinases (MAPKs).	14,15-epoxy-5,8,11-eicosatrienoic acid	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	76-94
25458486-6	2015	Our results showed that both Na3Au (S2O3)2 2H2O and HgCl2 induce substantial release of IL-8, but not IL-6, CCL2 or IL-10, from MoDc, PBMC, or THP-1 cells.	na3au (s2o3)2 2h2o	29-47	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
25458486-6	2015	Our results showed that both Na3Au (S2O3)2 2H2O and HgCl2 induce substantial release of IL-8, but not IL-6, CCL2 or IL-10, from MoDc, PBMC, or THP-1 cells.	Mercuric Chloride	52-57	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
25433332-8	2015	CB126 decreased the abundance of Interleukin-8 both at the mRNA and protein levels.	cb126	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	33-46
25723478-10	2015	H1R and H2R, but not H3R or H4R, were constitutively expressed by primary and immortalized cells, and epithelial histamine stimulation induced GM-CSF, TNFalpha, and IL-8, but not TSLP or eotaxin-3 secretion.	Histamine	113-122	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
25656974-7	2015	The expression of IL-8 and TNF-alpha was negatively correlated with l-lactate and positively correlated with NH3 and putrescine, whereas the expression of IFN-gamma was positively correlated with histamine and 4-ethylphenol (P&lt; 0 05).	L-lactate	68-77	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
25656974-7	2015	The expression of IL-8 and TNF-alpha was negatively correlated with l-lactate and positively correlated with NH3 and putrescine, whereas the expression of IFN-gamma was positively correlated with histamine and 4-ethylphenol (P&lt; 0 05).	Ammonia	109-112	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
25656974-7	2015	The expression of IL-8 and TNF-alpha was negatively correlated with l-lactate and positively correlated with NH3 and putrescine, whereas the expression of IFN-gamma was positively correlated with histamine and 4-ethylphenol (P&lt; 0 05).	Putrescine	117-127	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
25898559-8	2015	RESULTS: DP-M&amp;O decreased the levels of TNF-alpha, IL-1beta, IL-6, and IL-8 and increased that of IL-10 in a concentration-dependent manner.	3-(3,5-dichlorophenyl)-1-methyl-2,5-pyrrolidinedione	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
25898559-8	2015	RESULTS: DP-M&amp;O decreased the levels of TNF-alpha, IL-1beta, IL-6, and IL-8 and increased that of IL-10 in a concentration-dependent manner.	Adenosine Monophosphate	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
25723478-11	2015	Epithelial priming with the TLR3 ligand poly (I:C) induced H1R and H2R expression, and enhanced histamine-induced GM-CSF, TNFalpha, and IL-8 secretion.	Histamine	96-105	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
25689147-8	2015	Receiver-operator characteristic curves showed that IL-8 predicted the relative change in plasma creatinine less than 10% (area under curve (AUC), 0.80; P = 0.0007).	Creatinine	97-107	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
25821694-9	2015	At a distinct concentration (100 microg/mL) aSNP-plain displayed the highest cytotoxicity and IL-8 release in monocultures of A549.	asnp	44-48	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
25689147-9	2015	Multivariate analyses showed that lower IL-8 transcripts, longer time on dialysis, higher recipient body mass index and deceased donor type were associated with relative change in plasma creatinine at the first postoperative day less than 10%.	Creatinine	187-197	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
25689147-3	2015	We investigated whether transcript levels in mononuclear cells including IL-8 on the first postoperative day may be involved in immediate allograft dysfunction as defined by reduced relative change in plasma creatinine at the first postoperative day.	Creatinine	208-218	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
25556927-2	2015	In this paper, aluminum-free Mn-beta zeolite was hydrothermally synthesized in the SiO2-MnO2-(TEA)2O-NaF-H2O system.	Aluminum	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
25689147-7	2015	RESULTS: Transcript levels of IL-8 and S100A8 were significantly lower in patients with relative change in plasma creatinine less than 10% at the first postoperative day.	Creatinine	114-124	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
25659107-4	2015	Using a three-dimensional collagen assay chemokinetic and chemotactic migration induced by CXCL8 was inhibited with the pan PI3 Kinase inhibitor wortmannin.	Wortmannin	145-155	C-X-C motif chemokine ligand 8	Homo sapiens	91-96
25659107-5	2015	Analysis of the specific Class I PI3 Kinase catalytic isoforms alpha, delta and gamma using the inhibitors PIK-75, PIK-294 and AS-605240 respectively indicated differential roles in CXCL8-induced neutrophil migration.	5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione	127-136	C-X-C motif chemokine ligand 8	Homo sapiens	182-187
25659107-7	2015	AS-605240 markedly reduced CXCL8 induced chemokinetic migration but had no effect on CXCL8 induced chemotactic migration.	5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	27-32
25821678-8	2015	The PLLA-Fe particle showed a significant increase in the IL-8 release in hMSCs but not in hHSCs.	Iron	9-11	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
25849726-6	2015	RESULTS: Non-responders patients treated with macrolide containing regimens showed significantly lower levels of IL-6 and TNF-alpha in bronchoalveolar lavage fluid and lower IL-8 and IL-10 in blood than those patients treated with non-macrolide regimens.	Macrolides	46-55	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
25652132-8	2015	The TLR3 agonist poly I:C 10 mug/mL increased the IL-8 release in HBECs that was poorly inhibited by dexamethasone in smokers (24.5%) and smokers with COPD (21.6%).	Poly I-C	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
25556927-2	2015	In this paper, aluminum-free Mn-beta zeolite was hydrothermally synthesized in the SiO2-MnO2-(TEA)2O-NaF-H2O system.	sio2-mno2-(tea)2o	83-100	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
25658801-5	2015	Durum wheat extracts significantly inhibited the secretion of the pro-inflammatory IL-8 mediator at 66 microg/mL of phenolic acids and at 0.2 microg/mL of isoprenoids.	phenolic acid	116-130	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
25658801-5	2015	Durum wheat extracts significantly inhibited the secretion of the pro-inflammatory IL-8 mediator at 66 microg/mL of phenolic acids and at 0.2 microg/mL of isoprenoids.	Terpenes	155-166	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
25556927-2	2015	In this paper, aluminum-free Mn-beta zeolite was hydrothermally synthesized in the SiO2-MnO2-(TEA)2O-NaF-H2O system.	Water	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
25678784-7	2015	Inhibition of LPS-induced CXCL8 release by dexamethasone (10(-6) M) was reduced, and baseline and LPS-induced p38 MAPK activation increased in PBMCs of COPD.	Dexamethasone	43-56	C-X-C motif chemokine ligand 8	Homo sapiens	26-31
25172696-0	2015	Anti-inflammatory effect of chlorogenic acid on the IL-8 production in Caco-2 cells and the dextran sulphate sodium-induced colitis symptoms in C57BL/6 mice.	Chlorogenic Acid	28-44	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
25678784-8	2015	GW856553 (10(-9) and 10(-10) M) synergistically increased the inhibitory effect of dexamethasone (10(-8) and 10(-6) M) on LPS-induced CXCL8 release in COPD.	6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-N-(2,2-dimethylprpyl)-3-pyridinecarboxamide	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	134-139
25678784-8	2015	GW856553 (10(-9) and 10(-10) M) synergistically increased the inhibitory effect of dexamethasone (10(-8) and 10(-6) M) on LPS-induced CXCL8 release in COPD.	Dexamethasone	83-96	C-X-C motif chemokine ligand 8	Homo sapiens	134-139
25601738-9	2015	CONCLUSIONS: These findings suggest, for the first time, a potential effect of benzene exposure on ALA-D activity, CD80 and CD86 expression, IL-8 levels, which could be suggested as potential markers for the early detection of benzene-induced alterations.	Benzene	79-86	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
25661379-7	2015	Consistently, the combined exposure of romidepsin and bortezomib reversed the effects on IkappaB degradation as evident with IL-8, p50 and p65 (NF-kappaB) expression.	Bortezomib	54-64	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
25172696-2	2015	Effects of CHA and CHA metabolites were evaluated on the IL-8 production in human intestinal Caco-2 cells induced by combined stimulation with tumour necrosis factor alpha (TNFalpha) and H2O2.	Chlorogenic Acid	11-14	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
25172696-2	2015	Effects of CHA and CHA metabolites were evaluated on the IL-8 production in human intestinal Caco-2 cells induced by combined stimulation with tumour necrosis factor alpha (TNFalpha) and H2O2.	Chlorogenic Acid	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
25536369-5	2015	While the steroid dexamethasone brought about a 41.6% reduction in the IL-8 concentration in the supernatant, the 5kDaR reduced IL-8 by 59% (P &lt; 0.05) when compared to the TNFalpha stimulated Caco-2 cells.	Steroids	10-17	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
25536369-5	2015	While the steroid dexamethasone brought about a 41.6% reduction in the IL-8 concentration in the supernatant, the 5kDaR reduced IL-8 by 59% (P &lt; 0.05) when compared to the TNFalpha stimulated Caco-2 cells.	Dexamethasone	18-31	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
25172696-2	2015	Effects of CHA and CHA metabolites were evaluated on the IL-8 production in human intestinal Caco-2 cells induced by combined stimulation with tumour necrosis factor alpha (TNFalpha) and H2O2.	Hydrogen Peroxide	187-191	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
25172696-3	2015	CHA and caffeic acid (CA) inhibited TNFalpha- and H2O2-induced IL-8 production.	Chlorogenic Acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
25172696-3	2015	CHA and caffeic acid (CA) inhibited TNFalpha- and H2O2-induced IL-8 production.	caffeic acid	8-20	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
25172696-3	2015	CHA and caffeic acid (CA) inhibited TNFalpha- and H2O2-induced IL-8 production.	Hydrogen Peroxide	50-54	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
25561369-5	2015	RESULTS: Adrenaline(A), noradrenaline and the beta-AR agonist isoprenaline reduced N-formyl-Met-Leu-Phe (fMLP)-induced migration, CD11b/CD18 expression, and ROS production, without affecting IL-8.	Epinephrine	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
25398834-8	2015	Gene expression signature, induced by lenalidomide in nurse-like cells, indicated a reduction of pivotal pro-survival signals for chronic lymphocytic leukemia, such as CCL2, IGF1, CXCL12, HGF1, and supported a modulation towards M1 phenotype with high IL2 and low IL10, IL8 and CD163.	Lenalidomide	38-50	C-X-C motif chemokine ligand 8	Homo sapiens	270-273
25398638-7	2015	beta-Carotene significantly reduced IL8 (1,306.2-253.75 pg/ml), decreased light and heavy ferritin by 77.8 and 45.8%, respectively, and increased ferroportin by 59.9% (P &lt; 0.05).	beta Carotene	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	36-39
25398638-8	2015	Increasing iron concentrations and incubation periods resulted in increased IL8 release.	Iron	11-15	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
25398638-11	2015	beta-Carotene normalized the main iron-related proteins" levels, reduced IL8 production, and released intracellular trapped iron.	beta Carotene	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	73-76
25528475-8	2015	Our results revealed that T11TS therapy induced downregulation of TNF-alpha, IL-8, IL-6, and NF-kappaB confirmed by FACS assay and ELISA.	t11ts	26-31	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
25561369-5	2015	RESULTS: Adrenaline(A), noradrenaline and the beta-AR agonist isoprenaline reduced N-formyl-Met-Leu-Phe (fMLP)-induced migration, CD11b/CD18 expression, and ROS production, without affecting IL-8.	Norepinephrine	24-37	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
25561369-5	2015	RESULTS: Adrenaline(A), noradrenaline and the beta-AR agonist isoprenaline reduced N-formyl-Met-Leu-Phe (fMLP)-induced migration, CD11b/CD18 expression, and ROS production, without affecting IL-8.	Isoproterenol	62-74	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
24559390-10	2015	In human bronchial epithelial cells, ZnONP-induced interleukin-8 secretion was partially prevented by co-treatment with the Toll-like receptor 4 (TLR4) inhibitor.	znonp	37-42	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
23835780-10	2015	Our results show that alendronate inhibits keratinocyte viability, expression of IL-8, VEGF, and collagen type I which are intimately related to healing events and cell migration while promoting apoptosis.	Alendronate	22-33	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
25256809-8	2015	T-cell receptor (TCR) activation of PBMCs and nickel (Ni(2+) ) treatments of human dermal microvascular endothelial cells (HDMECs) were performed resulting in IL-4, IL-6, IL-8 and IL-17 production.	Nickel	46-52	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
25256809-8	2015	T-cell receptor (TCR) activation of PBMCs and nickel (Ni(2+) ) treatments of human dermal microvascular endothelial cells (HDMECs) were performed resulting in IL-4, IL-6, IL-8 and IL-17 production.	Nickel(2+)	54-60	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
25256809-11	2015	Similarly, TSC inhibits overproduction of IL-4 and IL-17 in T-cell receptor (TCR)-activated PBMCs as well as nickel induction of IL-6 and IL-8 in HDMECs.	Nickel	109-115	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
25453468-0	2015	The effect of the decoy molecule PA401 on CXCL8 levels in bronchoalveolar lavage fluid of patients with cystic fibrosis.	pa401	33-38	C-X-C motif chemokine ligand 8	Homo sapiens	42-47
25453468-2	2015	Glycosaminoglycans (GAGs) possess the ability to influence the chemokine profile of the CF lung by binding CXCL8 and protecting it from proteolytic degradation.	Glycosaminoglycans	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	107-112
25453468-3	2015	CXCL8 is maintained in an active state by this glycan interaction thus increasing infiltration of immune cells such as neutrophils into the lungs.	Polysaccharides	47-53	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
25453468-4	2015	As the CXCL8-based decoy PA401 displays no chemotactic activity, yet demonstrates glycan binding affinity, the aim of this study was to investigate the anti-inflammatory effect of PA401 on CXCL8 levels, and activity, in CF airway samples in vitro.	pa401	25-30	C-X-C motif chemokine ligand 8	Homo sapiens	7-12
25453468-4	2015	As the CXCL8-based decoy PA401 displays no chemotactic activity, yet demonstrates glycan binding affinity, the aim of this study was to investigate the anti-inflammatory effect of PA401 on CXCL8 levels, and activity, in CF airway samples in vitro.	pa401	180-185	C-X-C motif chemokine ligand 8	Homo sapiens	189-194
25453468-6	2015	CXCL8 in CF BALF pre and post exposure to PA401 was quantified by ELISA.	pa401	42-47	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
25453468-9	2015	RESULTS: Exposure of CF BALF to increasing concentrations of PA401 (50-1000pg/ml) over a time course of 2-12h in vitro, significantly reduced the level of detectable CXCL8 (P&lt;0.05).	pa401	61-66	C-X-C motif chemokine ligand 8	Homo sapiens	166-171
25453468-10	2015	Interestingly, PA401 engendered release of CXCL8 from GAGs exposing the chemokine susceptible to proteolysis.	pa401	15-20	C-X-C motif chemokine ligand 8	Homo sapiens	43-48
25453468-13	2015	CONCLUSION: PA401 can disrupt CXCL8:GAG complexes, rendering the chemokine susceptible to proteolytic degradation.	pa401	12-17	C-X-C motif chemokine ligand 8	Homo sapiens	30-35
25592441-6	2015	The aim of this paper is to evaluate the role of (18)F-NaF sodium fluoride ((18)F-NaF) positron emission tomography (PET) in distinguishing between septic and aseptic failure in hip and knee replacements, in addition to evaluating the feasibility of using multi-sequential (18)F-NaF PET-CT for the assessment of painful lower limb prostheses.	Sodium Fluoride	59-74	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
25453468-13	2015	CONCLUSION: PA401 can disrupt CXCL8:GAG complexes, rendering the chemokine susceptible to proteolytic degradation.	Glycosaminoglycans	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	30-35
25453468-14	2015	Clinical application of a CXCL8 decoy, such as PA401, may serve to decrease the inflammatory burden in the CF lung in vivo.	pa401	47-52	C-X-C motif chemokine ligand 8	Homo sapiens	26-31
25351664-6	2015	Moreover, the ability of 2PS to reduce H2 O2 -induced IL-8 secretion, a marker of inflammation and oxidative stress, was abrogated in Nrf2 knockdown cells.	Hydrogen Peroxide	39-44	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
25273157-7	2015	Treatment with levosimendan strongly attenuated IL-1beta-induced expression of IL-6 and IL-8 in HACM as well as E-selectin and ICAM-1 in ECs.	Simendan	15-27	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
25592441-6	2015	The aim of this paper is to evaluate the role of (18)F-NaF sodium fluoride ((18)F-NaF) positron emission tomography (PET) in distinguishing between septic and aseptic failure in hip and knee replacements, in addition to evaluating the feasibility of using multi-sequential (18)F-NaF PET-CT for the assessment of painful lower limb prostheses.	Sodium Fluoride	59-74	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
25592441-6	2015	The aim of this paper is to evaluate the role of (18)F-NaF sodium fluoride ((18)F-NaF) positron emission tomography (PET) in distinguishing between septic and aseptic failure in hip and knee replacements, in addition to evaluating the feasibility of using multi-sequential (18)F-NaF PET-CT for the assessment of painful lower limb prostheses.	Sodium Fluoride	59-74	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
25593029-0	2015	Involvement of intracellular calcium mobilization in IL-8 activation in human retinal pigment epithelial cells.	Calcium	29-36	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
25424854-11	2015	A greater increase in posttreatment urinary IL8 during the 6-week period was observed in patients receiving MMC + BCG compared with patients receiving BCG monotherapy.	Mitomycin	108-111	C-X-C motif chemokine ligand 8	Homo sapiens	44-47
25973337-1	2015	Fluorine 18 Sodium Fluoride ((18)F-NaF) (sodium fluoride) PET/CT is a highly sensitive but is a non-specific method for identifying bone metastases.	Fluorine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
25973337-1	2015	Fluorine 18 Sodium Fluoride ((18)F-NaF) (sodium fluoride) PET/CT is a highly sensitive but is a non-specific method for identifying bone metastases.	Sodium Fluoride	12-27	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
25973337-1	2015	Fluorine 18 Sodium Fluoride ((18)F-NaF) (sodium fluoride) PET/CT is a highly sensitive but is a non-specific method for identifying bone metastases.	Sodium Fluoride	41-56	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
25593029-3	2015	The purpose of this study is to understand the molecular mechanisms by which calcium signaling controls IL-8 activation in human RPE cells.	Calcium	77-84	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
25593029-7	2015	RESULTS: Our study reported that intracellular calcium mobilization activated IL-8 gene expression and secretion.	Calcium	47-54	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
25785032-0	2015	Ghrelin inhibits AngII -induced expression of TNF-alpha, IL-8, MCP-1 in human umbilical vein endothelial cells.	Ghrelin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
25593029-8	2015	Application of pharmacological inhibitor BAY 11-7082, siRNA, and plasmids of the nuclear factor kappa light chain enhancer of activated B cells (NF-kappaB) binding site, we identified that NF-kappaB is the main transcription factor involved in intracellular calcium mobilization-mediated IL-8 activation in human RPE cells.	Calcium	258-265	C-X-C motif chemokine ligand 8	Homo sapiens	288-292
25785032-5	2015	The aim of this study is to examine the effect of ghrelin on angiotension II (AngII)-induced expression of TNF-alpha, MCP-1, IL-8 in HUVECs.	Ghrelin	50-57	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
25593029-9	2015	CONCLUSIONS: Collectively, our findings highlight the important role of intracellular calcium mobilization in the activation of IL-8.	Calcium	86-93	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
25785032-10	2015	RESULT: our study showed that ghrelin inhibited AngII -induced expression of IL-8, TNF-alpha and MCP-1 in the HUVECs via GHSR pathway in concentration- and time-dependent manners.	Ghrelin	30-37	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
25757924-7	2015	In contrast, GJBRH significantly reduced the production of MDC, RANTES, and IL-8 compared with control cells simulated with TNF-alpha and IFN-gamma.	gjbrh	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
25559824-11	2015	Finally, PMA + ionomycin stimulation did not induce significant alterations on MSCs phenotype but did increase indoleamine-2,3-dioxygenase (IDO), inducible costimulatory ligand (ICOSL), IL-1beta, IL-8, and TNF-alpha mRNA expression.	Tetradecanoylphorbol Acetate	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
25559824-11	2015	Finally, PMA + ionomycin stimulation did not induce significant alterations on MSCs phenotype but did increase indoleamine-2,3-dioxygenase (IDO), inducible costimulatory ligand (ICOSL), IL-1beta, IL-8, and TNF-alpha mRNA expression.	Ionomycin	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
24285492-8	2015	RESULTS: In rheumatoid arthritis synovial fibroblasts (RASF), FFA dose-dependently enhanced the secretion of the proinflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, as well as the matrix-degrading enzymes pro-MMP1 and MMP3.	Fatty Acids, Nonesterified	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
26327186-4	2015	Stability of emixustat in blood collected with and without anticoagulant (NaF/KOx) on the VAMS device at ambient, refrigerated and frozen conditions was established.	vams	90-94	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
25445541-4	2015	The LPS-induced release of these cytokines was also modulated by purinergic receptor activation since IL-8 and MCP-1 release was decreased by the nucleotide scavenger apyrase as well as by the pharmacological P2Y6 receptor antagonists suramin and MRS2578.	Suramin	235-242	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
25445541-4	2015	The LPS-induced release of these cytokines was also modulated by purinergic receptor activation since IL-8 and MCP-1 release was decreased by the nucleotide scavenger apyrase as well as by the pharmacological P2Y6 receptor antagonists suramin and MRS2578.	N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea	247-254	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
25757924-8	2015	Consistently, GJBRH suppressed the mRNA expression of MDC, RANTES, and IL-8 in TNF-alpha and IFN-gamma-treated cells.	gjbrh	14-19	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
26339601-4	2015	In the present study, global expression profiling of short noncoding RNAs, in particular miRNAs and snoRNAs, was carried out in sodium fluoride (NaF) treated human osteosarcoma (HOS) cells to understand their possible role in the development of fluorosis.	Sodium Fluoride	128-143	C-X-C motif chemokine ligand 8	Homo sapiens	145-148
26339601-8	2015	We show that the alterations in UG dinucleotides and D-box sequences of snoRNAs could be due to NaF exposure.	Dinucleoside Phosphates	35-48	C-X-C motif chemokine ligand 8	Homo sapiens	96-99
26090385-6	2015	Cytokine expression analysis in media of sepiolite NC treated cultures showed a proinflammatory profile (INFgamma, IL-1alpha, IL-8, and IL-6), in contrast with clinoptilolite NC that induced lees cytokines with concomitant production of IL-10.	magnesium trisilicate	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
26491668-4	2015	Additionally, the expression of cyclooxygenase-2 (COX-2) and interleukin-8 (IL-8) mRNA was significantly reduced by the combination treatment as compared to the expression seen for treatment with cetuximab or cisplatin alone.	Cisplatin	209-218	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
26491668-4	2015	Additionally, the expression of cyclooxygenase-2 (COX-2) and interleukin-8 (IL-8) mRNA was significantly reduced by the combination treatment as compared to the expression seen for treatment with cetuximab or cisplatin alone.	Cisplatin	209-218	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
26491668-6	2015	Results demonstrate that combined treatment with cetuximab and cisplatin exerts synergistic anticancer effects on colon cancer cells and also suggest that the ERK pathway plays a critical role in these effects via the suppression of the EGFR signaling pathway, along with the inhibition of COX-2, IL-8, and AP-1 and NF-kappaB.	Cisplatin	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	297-301
25451615-0	2015	Increased cerebrospinal fluid interleukin-8 in bipolar disorder patients associated with lithium and antipsychotic treatment.	Lithium	89-96	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
26510263-6	2015	After 24 hours, compared to the isoflurane group, the propofol group had significantly lower levels of CRP (P &lt; 0.001), IL-6 (P &lt; 0.001) and IL-8 (P &lt; 0.001), with higher levels CD11 (P = 0.009) and CD18 (P = 0.002) expression.	Propofol	54-62	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
25451615-8	2015	IL-8 concentrations were positively associated to lithium- and antipsychotic treatment.	Lithium	50-57	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
24882386-7	2015	In TNF-alpha-treated neutrophils, pre-incubation with everolimus provided the most potent effect, simultaneously reducing the release of both VEGF and IL-8 while doubling the release of IL-1RA.	Everolimus	54-64	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
26121010-5	2015	The effect of leptin on IL-8 could visibly abolished by the inhibitor of PI3K LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
24882386-6	2015	Under basal conditions, mammalian target of rapamycin (mTOR) inhibitors (sirolimus and everolimus) had the most potent anti-inflammatory effect, decreasing both IL-8 release ( -80%) and vascular endothelial growth factor (VEGF) release ( -65%) and preserving the release of the anti-inflammatory cytokine interleukin-1 receptor antagonist (IL-1RA).	Sirolimus	73-82	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
25139172-4	2015	In general terms, non-flavonoid polyphenols reduce the production of inflammatory mediators, such as IL-1beta, IL-8, MCP-1, COX-2 or iNOS in these animal models of diabetes.	Polyphenols	32-43	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
24882386-6	2015	Under basal conditions, mammalian target of rapamycin (mTOR) inhibitors (sirolimus and everolimus) had the most potent anti-inflammatory effect, decreasing both IL-8 release ( -80%) and vascular endothelial growth factor (VEGF) release ( -65%) and preserving the release of the anti-inflammatory cytokine interleukin-1 receptor antagonist (IL-1RA).	Everolimus	87-97	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
25344634-7	2015	The serum concentrations of several sub-types of polychlorinated biphenyl (PCB) congeners were found to be significantly correlated with interleukin (IL)-8 mRNA expression among asthmatic children.	Polychlorinated Biphenyls	49-73	C-X-C motif chemokine ligand 8	Homo sapiens	137-155
26238371-6	2015	IL-1beta, IL-6, IL-8 and TNF-alpha production could be significantly upregulated and downregulated by a ROS activator or inhibitor, respectively.	Reactive Oxygen Species	104-107	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
26728736-2	2015	Ethanol-induced ulceration causes an increased transcription of IFNa, IL-8, and IL-12 mRNA in BMNCs.	Ethanol	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
26728736-4	2015	The sizes of acetate-induced damages were positively correlated with the expression of IL-10 and IL-8 genes in BMNCs and with the expression of IFNa, IL-2, IL-12, and TNF genes in GM cells.	Acetates	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
26728736-5	2015	Intranasal administration of Pro-Gly-Pro (PGP) reduced ethanol-induced ulceration, activating the transcription of IFNgamma, IL-2, and IL-4 mRNA in BMNCs and prevents the formation of stress- and acetateinduced ulcers by inhibiting the expression of IL-8 and IL-10 genes, respectively.	prolyl-glycyl-proline	29-40	C-X-C motif chemokine ligand 8	Homo sapiens	250-254
26728736-5	2015	Intranasal administration of Pro-Gly-Pro (PGP) reduced ethanol-induced ulceration, activating the transcription of IFNgamma, IL-2, and IL-4 mRNA in BMNCs and prevents the formation of stress- and acetateinduced ulcers by inhibiting the expression of IL-8 and IL-10 genes, respectively.	prolyl-glycyl-proline	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	250-254
25344634-7	2015	The serum concentrations of several sub-types of polychlorinated biphenyl (PCB) congeners were found to be significantly correlated with interleukin (IL)-8 mRNA expression among asthmatic children.	Polychlorinated Biphenyls	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	137-155
25344634-10	2015	In conclusion, IL-8 and IL-22 mRNA expressions could be useful biomarkers for detecting sub-populations of children who are particularly vulnerable to the adverse health effects of environmental pollutants, especially PCBs.	Polychlorinated Biphenyls	218-222	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
25972907-9	2015	Within the PG2 signature, there were five genes associated with doxorubicin: IL-8, MDM4, BCL2, PRODH2, and BIRC5.	Doxorubicin	64-75	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
26495958-6	2015	In H292 cells, fully-sulfated HMW heparin significantly reduced LPS-induced gene expression of both COX-2 and CXCL-8 for up to 48 hours, while desulfated heparin had little to no significant suppressive effect on signaling or on COX-2 gene or protein expression.	Heparin	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	110-116
25055998-7	2015	We also found that poly-IC-induced mRNA expression of other proinflammatory mediators such as MCP-1, RANTES, and IL-8 was suppressed by licochalcone A.	Poly I-C	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
25055998-7	2015	We also found that poly-IC-induced mRNA expression of other proinflammatory mediators such as MCP-1, RANTES, and IL-8 was suppressed by licochalcone A.	licochalcone	136-148	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
26495958-8	2015	In contrast, in normal HBE-1 cells, fully sulfated heparin significantly suppressed only ERK signaling, COX-2 gene expression at 12 hours, and CXCL-8 gene expression at 6 and 12 hours, while desulfated heparin had no significant effects on LPS-stimulated signaling or on gene or protein expression.	Heparin	51-58	C-X-C motif chemokine ligand 8	Homo sapiens	143-149
25838833-7	2015	BHSST significantly suppressed the production of RANTES/CCL5, TARC/CCL17, MDC/CCL22, and IL-8 in TI-stimulated HaCaT cells.	bhsst	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
26495958-7	2015	Desulfated heparin, initially ineffective at preventing LPS-induced CXCL8 up-regulation, reduced CXCL8 transcription at 24 hours.	Heparin	11-18	C-X-C motif chemokine ligand 8	Homo sapiens	97-102
26121924-5	2015	Peiminine inhibits the production of the pro-inflammatory cytokine, such as interleukin (IL)-6, IL-8, tumor necrosis factor-alpha (TNF-alpha) and IL-1beta (IL-1beta).	peiminine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
26436853-0	2015	Short-Chain Fatty Acids Regulate Secretion of IL-8 from Human Intestinal Epithelial Cell Lines in vitro.	Fatty Acids, Volatile	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
25312962-6	2015	NaHS treatment reduced both spontaneous and IL-1beta-induced secretion of IL-6, IL-8 and RANTES in different experimental settings.	sodium bisulfide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
25817163-5	2015	At 40 and/or 100 mug/ml, mtDAMPs activated human neutrophils, indicated by a significant reduction in the surface expression of L-selectin, and triggered a number of functional responses from both resting and tumour necrosis factor-alpha primed neutrophils, which included reactive oxygen species (ROS) generation, degranulation, secretion of interleukin-8 and activation of p38 and ERK1/2 MAPKs.	mtdamps	25-32	C-X-C motif chemokine ligand 8	Homo sapiens	343-356
25817163-8	2015	Interestingly, pharmacological inhibition of p38 or ERK1/2 either alone or in combination significantly inhibited L-selectin shedding and IL-8 secretion by mtDAMP-challenged neutrophils, revealing for the first time that MAPK activation is required for mtDAMP-induced neutrophil activation and function.	mtdamp	156-162	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
25433806-7	2015	Furthermore, the inhibition of PCA on LPS-induced IL-6 and IL-8 production can be reversed by PPAR-gamma antagonist GW9662.	2-chloro-5-nitrobenzanilide	116-122	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
25471891-0	2015	Piperine Suppresses the Expression of CXCL8 in Lipopolysaccharide-Activated SW480 and HT-29 Cells via Downregulating the Mitogen-Activated Protein Kinase Pathways.	piperine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	38-43
25471891-5	2015	Importantly, piperine dose-dependently suppressed LPS-induced secretion of CXCL8 and the expression of CXCL8 messenger RNA (mRNA).	piperine	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	75-80
25471891-5	2015	Importantly, piperine dose-dependently suppressed LPS-induced secretion of CXCL8 and the expression of CXCL8 messenger RNA (mRNA).	piperine	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	103-108
25471891-8	2015	Collectively, our results indicated that piperine could attenuate the inflammatory response in epithelial cells via downregulating the MAPK signaling and thus the expression of CXCL8, suggesting its potential application in anti-inflammation therapy.	piperine	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	177-182
24806275-2	2015	The goal of this study was to investigate the potential for Mn(2+), via its pro-oxidative properties, to activate production of pro-inflammatory cytokines/chemokines IL-1beta, IL-6, IL-8, IFNgamma, TNFalpha, and G-CSF by human monocyte-derived macrophages in vitro.	Manganese(2+)	60-66	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
26054185-4	2015	The positive control dentifrice contained 1450 ppm fluoride as sodium fluoride (NaF), in a silica base.	silica base	91-102	C-X-C motif chemokine ligand 8	Homo sapiens	80-83
24806275-5	2015	Exposure of the cells to LPS caused modest statistically insignificant increases in cytokine production; MnCl2 caused dose-related increases in production of all six cytokines (achieving statistical significance of p &lt; 0.0171- &lt; 0.0005 for IL-1beta, IL-6, IL-8, IFNgamma, and TNFalpha).	manganese chloride	105-110	C-X-C motif chemokine ligand 8	Homo sapiens	262-266
24806275-6	2015	In the case of LPS and MnCl2 combinations, the observed increases in production of IL-1beta, IL-6, IL-8, IFNgamma, and G-CSF were greater than those seen with cells exposed to the individual agents.	manganese chloride	23-28	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
26634216-7	2015	Hydroxy-3-methoxyaceto-phenone (HMAP), diphenyleneiodonium (DPI), and siRNA Nox2 reduced the ROS and IL-8 release in neutrophils treated with fMLP.	hydroxy-3-methoxyaceto-phenone	0-30	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
26634216-7	2015	Hydroxy-3-methoxyaceto-phenone (HMAP), diphenyleneiodonium (DPI), and siRNA Nox2 reduced the ROS and IL-8 release in neutrophils treated with fMLP.	diphenyleneiodonium	39-58	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
26634216-7	2015	Hydroxy-3-methoxyaceto-phenone (HMAP), diphenyleneiodonium (DPI), and siRNA Nox2 reduced the ROS and IL-8 release in neutrophils treated with fMLP.	diphenyleneiodonium	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
26634216-10	2015	We showed that IL-8 release induced by fMLP is dependent on NADPH oxidase, and ROS could play a redundant role in cell signalling, ultimately activating the PI3K/Akt and NF-kappaB pathways in neutrophils.	ros	79-82	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
26328410-4	2015	Nanotube diameter and layer changed with different concentration of NaF in 1 M H3PO4 at the same voltage.	phosphoric acid	79-84	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
26039682-8	2015	Particles from both Pb-containing and Pb-free ammunition were able to induce oxidative stress and the proinflammatory marker interleukin (IL)-8 in both in vitro systems.	Lead	20-22	C-X-C motif chemokine ligand 8	Homo sapiens	125-143
26609426-0	2015	Effects of Lutein and Zeaxanthin on LPS-Induced Secretion of IL-8 by Uveal Melanocytes and Relevant Signal Pathways.	Zeaxanthins	22-32	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
26609426-8	2015	The present study demonstrated that lutein and zeaxanthin inhibited LPS-induced secretion of IL-8 in cultured UM via JNK and NF-kappaB signal pathways.	Zeaxanthins	47-57	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
25506634-3	2015	Under the cell-free condition, CB and TiO2 NP showed a high adsorption affinity for IL-8 in supernatants of both lipopolysaccharide (LPS)-stimulated and unstimulated A549 cells.	titanium dioxide	38-42	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
26039682-8	2015	Particles from both Pb-containing and Pb-free ammunition were able to induce oxidative stress and the proinflammatory marker interleukin (IL)-8 in both in vitro systems.	Lead	38-40	C-X-C motif chemokine ligand 8	Homo sapiens	125-143
25653478-6	2015	We found that THC suppressed the release of proinflammatory factors, including tumor necrosis factor alpha (TNF-alpha), interleukin- (IL-) 1beta, IL-6, and IL-8, decreased nuclear factor-kappaB (NF-kappaB) expression, and inhibited the upregulation of cofilin-1 protein in the LPS-stimulated MG-63 cells.	Dronabinol	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
25605997-0	2015	Peptidoglycan Induces the Production of Interleukin-8 via Calcium Signaling in Human Gingival Epithelium.	Calcium	58-65	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
25605997-3	2015	The triggering of calcium signaling induces the secretion of pro-inflammatory cytokines such as interleukin-8 as part of the inflammatory response; however, the exact mechanism of calcium signaling induced by bacterial toxins when gingival epithelial cells are exposed to pathogens is unclear.	Calcium	18-25	C-X-C motif chemokine ligand 8	Homo sapiens	96-109
25605997-3	2015	The triggering of calcium signaling induces the secretion of pro-inflammatory cytokines such as interleukin-8 as part of the inflammatory response; however, the exact mechanism of calcium signaling induced by bacterial toxins when gingival epithelial cells are exposed to pathogens is unclear.	Calcium	180-187	C-X-C motif chemokine ligand 8	Homo sapiens	96-109
25605997-7	2015	Peptidoglycan-mediated interleukin-8 expression was blocked by U73122 and 1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid tetrakis (acetoxymethyl ester).	1,2-bis(2-aminophenoxy)ethane-n,n,n",n"-tetraacetic acid tetrakis (acetoxymethyl ester	74-160	C-X-C motif chemokine ligand 8	Homo sapiens	23-36
25605997-8	2015	Moreover, interleukin-8 expression was induced by thapsigargin, a selective inhibitor of the sarco/endoplasmic reticulum calcium ATPase, when thapsigargin was treated alone or co-treated with peptidoglycan.	Thapsigargin	50-62	C-X-C motif chemokine ligand 8	Homo sapiens	10-23
25605997-8	2015	Moreover, interleukin-8 expression was induced by thapsigargin, a selective inhibitor of the sarco/endoplasmic reticulum calcium ATPase, when thapsigargin was treated alone or co-treated with peptidoglycan.	Thapsigargin	142-154	C-X-C motif chemokine ligand 8	Homo sapiens	10-23
25605997-9	2015	These results suggest that the gram-positive bacterial toxin peptidoglycan induces calcium signaling via the phospholipase C/inositol 1,4,5-trisphosphate pathway, and that increased interleukin-8 expression is mediated by intracellular calcium levels in human gingival epithelial cells.	Calcium	236-243	C-X-C motif chemokine ligand 8	Homo sapiens	182-195
25925366-10	2015	We demonstrate that the experimental use of naturally occurring plant diterpenes such as gibberellin on lipopolysaccharide-stimulated cell lines reduces IL-8 release in an A20-dependent manner.	Diterpenes	70-80	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
25925366-10	2015	We demonstrate that the experimental use of naturally occurring plant diterpenes such as gibberellin on lipopolysaccharide-stimulated cell lines reduces IL-8 release in an A20-dependent manner.	Gibberellins	89-100	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
26600671-8	2015	In HaCaT keratinocytes histamine and TNF-alpha induced IL-8 and MMP-1 expression was reduced by amarogentin to a similar extent as with azelastine.	Histamine	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
25977597-3	2015	In this study, we wanted to assess the efficacy of both low and high doxycycline doses in modulating IL-8, TNF-alpha, and IL-6 gene expression in HaCaT cells stimulated with LPS.	Doxycycline	69-80	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
26556954-3	2015	RAFLS incubated with CoCl2, but not S1P, produced less IL-8 and MCP-1 than normal FLS.	cobaltous chloride	21-26	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
26640326-8	2015	PM10-mediated Ca(2+) signal and IL-8 expression were attenuated by several pharmacological blockades such as antioxidants, IP3-PLC blockers, and TRPM2 inhibitors.	Inositol 1,4,5-Trisphosphate	123-126	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
25405261-4	2015	There were major differences between the types of NMs; exposure to ZnO and Ag resulted in cytotoxicity and increased gene expression levels of HMOX1 and IL8.	Zinc Oxide	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	153-156
26652669-5	2015	Rapamycin treatment induced the upregulation of cytokine genes, including those from the Interleukin (IL)-6 signaling network, such as IL-8 and the Leukemia Inhibitory Factor (LIF), while quiescent fibroblasts demonstrated up-regulation of genes involved in the complement and coagulation cascade.	Sirolimus	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
25124219-4	2015	The aim of this study was to evaluate the functional relationship between the activity of arterial mineral deposition and regional bone metabolism as assessed by (18)F-sodium fluoride (NaF) PET/CT.	Sodium Fluoride	168-183	C-X-C motif chemokine ligand 8	Homo sapiens	185-188
25500537-8	2015	S-CMC treatment increased HDAC2 recruitment and suppressed H4 acetylation of the IL-8 promoter, and this effect was further ablated by addition of buthionine sulfoximine, a specific inhibitor of GSH synthesis.	Buthionine Sulfoximine	147-169	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
25500537-8	2015	S-CMC treatment increased HDAC2 recruitment and suppressed H4 acetylation of the IL-8 promoter, and this effect was further ablated by addition of buthionine sulfoximine, a specific inhibitor of GSH synthesis.	Glutathione	195-198	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
25998443-5	2015	METHODS: The effect of ambroxol and/or beclomethasone dipropionate on IL-8, RANTES and iNOS levels was assessed by Western blot analysis; IL-8, MPO and 3-NT levels were measured by ELISA.	Ambroxol	23-31	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
25791156-7	2015	Hydrogen peroxide (H2O2), cytomix (tumour necrosis factor-alpha + IL-1beta + interferon-gamma) and lipopolysaccharide (LPS) upregulated IL-8 mRNA at 1 or 2 h. p38 MAPKalpha mRNA was significantly increased after H2O2 and LPS treatment.	Hydrogen Peroxide	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
25998443-5	2015	METHODS: The effect of ambroxol and/or beclomethasone dipropionate on IL-8, RANTES and iNOS levels was assessed by Western blot analysis; IL-8, MPO and 3-NT levels were measured by ELISA.	Beclomethasone	39-66	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
25791156-7	2015	Hydrogen peroxide (H2O2), cytomix (tumour necrosis factor-alpha + IL-1beta + interferon-gamma) and lipopolysaccharide (LPS) upregulated IL-8 mRNA at 1 or 2 h. p38 MAPKalpha mRNA was significantly increased after H2O2 and LPS treatment.	Hydrogen Peroxide	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
25998443-8	2015	Ambroxol suppressed LPS-induced RANTES expression and IL-8 release (p &lt; 0.001), whilst inhibiting iNOS expression (p &lt; 0.05).	Ambroxol	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
25791156-7	2015	Hydrogen peroxide (H2O2), cytomix (tumour necrosis factor-alpha + IL-1beta + interferon-gamma) and lipopolysaccharide (LPS) upregulated IL-8 mRNA at 1 or 2 h. p38 MAPKalpha mRNA was significantly increased after H2O2 and LPS treatment.	Hydrogen Peroxide	212-216	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
25998443-9	2015	Beclomethasone dipropionate had no effect on RANTES but halved iNOS expression and IL-8 release.	Beclomethasone	0-27	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
25998443-4	2015	OBJECTIVES: We evaluated the ability of ambroxol and/or beclomethasone dipropionate to inhibit LPS-induced expression/release of RANTES, IL-8, inducible NO synthase (iNOS), myeloperoxidase (MPO) and 3-nitrotyrosine (3-NT: nitrosative stress biomarker) in BEAS-2B +- PMNs stimulated with LPS (1 mug/ml).	Ambroxol	40-48	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
25998443-11	2015	Ambroxol and beclomethasone dipropionate inhibited LPS-stimulated IL-8, MPO and 3-NT release (p &lt; 0.05).	Ambroxol	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
25998443-11	2015	Ambroxol and beclomethasone dipropionate inhibited LPS-stimulated IL-8, MPO and 3-NT release (p &lt; 0.05).	Beclomethasone	13-40	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
25998443-12	2015	Ambroxol/beclomethasone dipropionate combination potentiated the inhibition of IL-8 and 3-NT production in BEAS-2B with PMNs (p &lt; 0.05 and p &lt; 0.01, respectively).	Ambroxol	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	79-89
25998443-12	2015	Ambroxol/beclomethasone dipropionate combination potentiated the inhibition of IL-8 and 3-NT production in BEAS-2B with PMNs (p &lt; 0.05 and p &lt; 0.01, respectively).	Beclomethasone	9-36	C-X-C motif chemokine ligand 8	Homo sapiens	79-89
25998443-14	2015	CONCLUSION: The additive effect of ambroxol and beclomethasone dipropionate on IL-8 and 3-NT inhibition suggests new therapeutic options in the treatment of neutrophil-related respiratory diseases such as chronic obstructive pulmonary disease and respiratory infections.	Ambroxol	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	79-89
25998443-14	2015	CONCLUSION: The additive effect of ambroxol and beclomethasone dipropionate on IL-8 and 3-NT inhibition suggests new therapeutic options in the treatment of neutrophil-related respiratory diseases such as chronic obstructive pulmonary disease and respiratory infections.	Beclomethasone	48-75	C-X-C motif chemokine ligand 8	Homo sapiens	79-89
25884029-7	2015	VEGF and IL-8 correlated positively with LDH and PAI-1/tPA ratio and negatively with tPA in both loculated and nonloculated TBPE.	Tetradecanoylphorbol Acetate	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
25475379-1	2015	The use of (18)F-sodium fluoride ((18)F-NaF) with PET/CT is increasing.	Sodium Fluoride	17-32	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
25884029-7	2015	VEGF and IL-8 correlated positively with LDH and PAI-1/tPA ratio and negatively with tPA in both loculated and nonloculated TBPE.	Tetradecanoylphorbol Acetate	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
25884029-7	2015	VEGF and IL-8 correlated positively with LDH and PAI-1/tPA ratio and negatively with tPA in both loculated and nonloculated TBPE.	tbpe	124-128	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
25481140-8	2014	Using this method we then calculate the isotropic dipole polarizabilities for F(-), Cl(-), O(2-), and S(2-) embedded in the LiF, LiCl, NaF, NaCl, KF, KCl, ZnO, ZnS, MgO, MgS, CaO, CaS, SrO, SrS, BaO, BaS, and other crystals containing halogen, oxygen, or sulphur anions.	dipole	50-56	C-X-C motif chemokine ligand 8	Homo sapiens	135-138
25506832-9	2014	Using PCR we confirmed the significant up-regulation and down-regulation of miR-493-5p and IL8 by imatinib treatment, respectively in K562 cells.	Imatinib Mesylate	98-106	C-X-C motif chemokine ligand 8	Homo sapiens	91-94
25506832-12	2014	The IL8 inhibition also further sensitized K562 cells to imatinib cytotoxicity (p &lt; 0.0001).	Imatinib Mesylate	57-65	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
25540590-0	2014	Differential NF-kappaB and MAPK activation underlies fluoride- and TPA-mediated CXCL8 (IL-8) induction in lung epithelial cells.	Fluorides	53-61	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
25540590-0	2014	Differential NF-kappaB and MAPK activation underlies fluoride- and TPA-mediated CXCL8 (IL-8) induction in lung epithelial cells.	Tetradecanoylphorbol Acetate	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
25540590-0	2014	Differential NF-kappaB and MAPK activation underlies fluoride- and TPA-mediated CXCL8 (IL-8) induction in lung epithelial cells.	Tetradecanoylphorbol Acetate	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
25540590-3	2014	To approach this, we compared the potential of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), and sodium fluoride (NaF) to induce CXCL8 responses in A549 cells, with emphasis on the importance of nuclear factor kappa B (NF-kappaB)- and mitogen-activated protein kinase (MAPK) signaling.	Phorbol Esters	51-64	C-X-C motif chemokine ligand 8	Homo sapiens	146-151
25540590-3	2014	To approach this, we compared the potential of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), and sodium fluoride (NaF) to induce CXCL8 responses in A549 cells, with emphasis on the importance of nuclear factor kappa B (NF-kappaB)- and mitogen-activated protein kinase (MAPK) signaling.	Tetradecanoylphorbol Acetate	66-102	C-X-C motif chemokine ligand 8	Homo sapiens	146-151
25540590-3	2014	To approach this, we compared the potential of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), and sodium fluoride (NaF) to induce CXCL8 responses in A549 cells, with emphasis on the importance of nuclear factor kappa B (NF-kappaB)- and mitogen-activated protein kinase (MAPK) signaling.	Tetradecanoylphorbol Acetate	104-107	C-X-C motif chemokine ligand 8	Homo sapiens	146-151
25540590-3	2014	To approach this, we compared the potential of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), and sodium fluoride (NaF) to induce CXCL8 responses in A549 cells, with emphasis on the importance of nuclear factor kappa B (NF-kappaB)- and mitogen-activated protein kinase (MAPK) signaling.	Sodium Fluoride	114-129	C-X-C motif chemokine ligand 8	Homo sapiens	146-151
25540590-4	2014	Notably, TPA induced a greater release of CXCL8 than did NaF.	Tetradecanoylphorbol Acetate	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	42-47
25608815-4	2015	The results showed that, most of the cytokines or receptors had obvious expression change compared with the control (without Poly I:C stimulation), especially the three cytokine genes IL6, IL8 and IL10, whose average expression change times were 20.71, 10.87 and 5.18, respectively.	Poly I-C	125-133	C-X-C motif chemokine ligand 8	Homo sapiens	189-192
25540590-5	2014	Furthermore, TPA induced a strong, rapid, but transient upregulation of CXCL8 messenger (m)RNA, whereas NaF induced a weaker, more delayed, but persistent upregulation.	Tetradecanoylphorbol Acetate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	72-77
25540590-10	2014	The CXCL8 responses by TPA and NaF were reduced by p65-siRNA.	Tetradecanoylphorbol Acetate	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	4-9
25266909-1	2014	Nitrogen-doped TiO2 nanoparticles have been synthesized using sol-gel methods and subsequently fluorinated at room temperature by aging in acidic solutions of NaF.	Nitrogen	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	159-162
25266909-1	2014	Nitrogen-doped TiO2 nanoparticles have been synthesized using sol-gel methods and subsequently fluorinated at room temperature by aging in acidic solutions of NaF.	titanium dioxide	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	159-162
25266909-3	2014	After aging at room temperature in NaF solutions, the Ti-OH groups on the surface of the TiO2 nanoparticles were replaced by Ti-F bonds, which resulted in a decrease of the point of zero charge from pH 5.4 to 2.8.	titanium dioxide	89-93	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
25378098-2	2014	Reaction is initiated by an electron impacting a helium nanodroplet containing sodium atoms and SF6 molecules, leading to preferential production of energetically favorable structures based on the unit cell of crystalline NaF.	Helium	49-55	C-X-C motif chemokine ligand 8	Homo sapiens	222-225
25474105-8	2014	Ramipril reduces mRNA expression of multiple pro-inflammatory cytokines such as IL-1beta, IL-6, IL-8, TNF -alpha, Interferon-[Formula: see text], and MCP-1, as well as aortic wall IL-8 and MCP-1 (P = 0.017 and 0.008, respectively) protein content.	Ramipril	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
25474105-8	2014	Ramipril reduces mRNA expression of multiple pro-inflammatory cytokines such as IL-1beta, IL-6, IL-8, TNF -alpha, Interferon-[Formula: see text], and MCP-1, as well as aortic wall IL-8 and MCP-1 (P = 0.017 and 0.008, respectively) protein content.	Ramipril	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
25622744-15	2014	CONCLUSION: Dexmedetomidine preconditioning attenuate remote lung injury of lower limb ischemia-reperfusion, and the mechanism may be related to down-regulation of monocytes TLR4 expression and degradation of IL-6, IL-8 and TNF-alpha level.	Dexmedetomidine	12-27	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
25378098-2	2014	Reaction is initiated by an electron impacting a helium nanodroplet containing sodium atoms and SF6 molecules, leading to preferential production of energetically favorable structures based on the unit cell of crystalline NaF.	Sodium	79-85	C-X-C motif chemokine ligand 8	Homo sapiens	222-225
25399576-5	2014	The majority of angiogenic cytokines, including VEGF-A, FGF2, IL-8 and SDF-1alpha, manifest an obligate dependence on heparan sulfate (HS) for their biological activity.	Heparitin Sulfate	135-137	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
25268952-6	2014	Along with IL-1beta, exposure to MG-132 and bafilomycin A1 resulted in the secretion of IL-8.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	33-39	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
25268952-6	2014	Along with IL-1beta, exposure to MG-132 and bafilomycin A1 resulted in the secretion of IL-8.	bafilomycin	44-55	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
25399576-5	2014	The majority of angiogenic cytokines, including VEGF-A, FGF2, IL-8 and SDF-1alpha, manifest an obligate dependence on heparan sulfate (HS) for their biological activity.	Heparitin Sulfate	118-133	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
25312381-4	2014	Sodium fluoride (NaF) had pro-proliferation effects at relatively moderate concentration, with 5 x 10(3) mumol/L having the best effects.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
25312381-9	2014	A BMP specific inhibitor LDN193189 suppressed cell proliferation induced by 5 x 10(3) mumol/L NaF.	LDN 193189	25-34	C-X-C motif chemokine ligand 8	Homo sapiens	94-97
25138760-8	2014	RESULTS: Rebamipide suppressed the release of interleukin (IL)-8 and the upregulation of IL-8 mRNA induced by tumour necrosis factor alpha (TNF-alpha) or LPS in corneal fibroblasts.	rebamipide	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	46-64
25138760-8	2014	RESULTS: Rebamipide suppressed the release of interleukin (IL)-8 and the upregulation of IL-8 mRNA induced by tumour necrosis factor alpha (TNF-alpha) or LPS in corneal fibroblasts.	rebamipide	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
25236743-6	2014	Moreover, we observed that in a first phase, DNFB-induced ATF4 upregulates IL8 mRNA levels while blocking CD86, IL1B, IL12B, and CXL10 transcription.	Dinitrofluorobenzene	45-49	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
25256070-3	2014	This study investigates the effects of ramipril on the oxidoinflammatory cytokines (IL-6, IL-8, TNF-alpha) and TnT (myocardial injury marker) and their alteration in association with ACE I/D gene polymorphisms.	Ramipril	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
25168931-1	2014	The functional imaging technique of dynamic fluorine-18 labeled sodium fluoride positron emission tomography ((18)F-NaF PET) allows the quantitative assessment of regional bone formation by measuring the plasma clearance of fluoride to bone at any site in the skeleton.	Fluorine-18	44-55	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
25168931-1	2014	The functional imaging technique of dynamic fluorine-18 labeled sodium fluoride positron emission tomography ((18)F-NaF PET) allows the quantitative assessment of regional bone formation by measuring the plasma clearance of fluoride to bone at any site in the skeleton.	Sodium Fluoride	64-79	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
25168931-1	2014	The functional imaging technique of dynamic fluorine-18 labeled sodium fluoride positron emission tomography ((18)F-NaF PET) allows the quantitative assessment of regional bone formation by measuring the plasma clearance of fluoride to bone at any site in the skeleton.	Fluorides	71-79	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
25251945-6	2014	The beta-glucan-consisting glycans curdlan and zymosan stimulated IL-8 and CCL2 secretion by IEC lines.	beta-Glucans	4-15	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
25251945-6	2014	The beta-glucan-consisting glycans curdlan and zymosan stimulated IL-8 and CCL2 secretion by IEC lines.	Polysaccharides	27-34	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
25251945-6	2014	The beta-glucan-consisting glycans curdlan and zymosan stimulated IL-8 and CCL2 secretion by IEC lines.	Zymosan	47-54	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
25201328-7	2014	RESULTS: IL-1Ra, IL-6, IL-8, IL-10, IL-15, and MCP-1 were significantly elevated in the PTAA group.	ptaa	88-92	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
25384214-6	2014	TANs produced substantial quantities of the proinflammatory factors MCP-1, IL-8, MIP-1alpha, and IL-6, as well as the antiinflammatory IL-1R antagonist.	tans	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
25448498-6	2014	Furthermore, clozapine and haloperidol can increase the myeloperoxidase activity and IL-8 production in neutrophils.	Clozapine	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
25448498-6	2014	Furthermore, clozapine and haloperidol can increase the myeloperoxidase activity and IL-8 production in neutrophils.	Haloperidol	27-38	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
24999595-0	2014	Silver nanoparticle-induced hMSC proliferation is associated with HIF-1alpha-mediated upregulation of IL-8 expression.	Silver	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
25220290-7	2014	RESULTS: The addition of 0.25% CaGP improved the remineralization potential of low-fluoride toothpastes and the NaF as source of fluoride yielded the best results (p&lt;0.001) as evidenced by the hardness analysis.	Fluorides	129-137	C-X-C motif chemokine ligand 8	Homo sapiens	112-115
25260438-12	2014	CLINICAL SIGNIFICANCE: This study showed that a 1.1% NaF dentifrice (5000ppm) demonstrated greater remineralization ability than the CPP-ACP topical tooth creme and that the addition of fluoride to its formulation seems to enhance remineralization.	Fluorides	186-194	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
25335112-0	2014	Berberine hydrochloride IL-8 dependently inhibits invasion and IL-8-independently promotes cell apoptosis in MDA-MB-231 cells.	berberine chloride	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
25364454-6	2014	Alterations in carcinoembryonic antigen (CEA), interleukin-8 (IL-8) and cyclooxygenase-2 (COX-2) mRNA expression levels subsequent to pioglitazone treatment were examined in BxPC-3 cells by quantitative reverse transcription polymerase chain reaction.	Pioglitazone	134-146	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
25364454-9	2014	Pioglitazone induced CEA mRNA expression, suppressed IL-8 and COX-2 mRNA expression in vitro, and inhibited BxPC-3 xenograft growth.	Pioglitazone	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
25461914-4	2014	TBBPA enhanced release of interleukin (IL)-6, IL-8, and prostaglandin E2 (PGE2), and suppressed TGF-beta release in HTR-8/SVneo cells.	tetrabromobisphenol A	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
25521357-0	2014	Pharmacogenetic interaction analysis of VEGFR-2 and IL-8 polymorphisms in advanced breast cancer patients treated with paclitaxel and bevacizumab.	Paclitaxel	119-129	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
25264520-10	2014	Human AEC pre-treated with IL-4 and IL-13, then stimulated with poly I:C, similarly exhibited significantly higher expression of IL8, CXCL9, CXCL10, CXCL11 and CCL5 genes.	Poly I-C	64-72	C-X-C motif chemokine ligand 8	Homo sapiens	129-132
25432084-4	2014	Therefore, the aim of this study was to evaluate, in the human lung adenocarcinoma cell line GLC-82, the effects of a 24-hour treatment with simvastatin on hydrogen peroxide (H2O2)-induced changes in cell viability, ERK phosphorylation, matrix metalloproteinase (MMP) expression, innate immunity signaling, NF-kappaB activation and IL-8 secretion.	Simvastatin	141-152	C-X-C motif chemokine ligand 8	Homo sapiens	332-336
25257954-3	2014	We found the concentrations of IL-8, TNF-alpha, and TGF-alpha presented in urine were significantly elevated in the high urinary arsenic workers compared with the low urinary arsenic workers.	Arsenic	129-136	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
25257954-4	2014	Multiple regression analysis showed that the urinary IL-8 level was significantly positively associated with urinary iAs concentration after adjusting for the confounding effects of age, employed years, body mass index (BMI), smoking, alcohol, and seafood consumption in recent 3 days.	Alcohols	235-242	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
25257954-8	2014	These data indicated that arsenic increased the secretion of inflammatory factors and IL-8, TNF-alpha, and TGF-alpha expression may be a useful biomarker of the effect of arsenic exposure.	Arsenic	26-33	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
25257954-8	2014	These data indicated that arsenic increased the secretion of inflammatory factors and IL-8, TNF-alpha, and TGF-alpha expression may be a useful biomarker of the effect of arsenic exposure.	Arsenic	171-178	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
25135357-2	2014	At molecular level, GSNO effects have been shown to modulate the activity of a series of transcription factors (notably NF-kappaB, AP-1, CREB and others) as well as other components of signal transduction chains (e.g. IKK-beta, caspase 1, calpain and others), resulting in the modulation of several cytokines and chemokines expression (TNFalpha, IL-1beta, IFN-gamma, IL-4, IL-8, RANTES, MCP-1 and others).	S-Nitrosoglutathione	20-24	C-X-C motif chemokine ligand 8	Homo sapiens	373-377
25399172-3	2014	In this report, we present the measurement of changes of the orientational angle of the "free OH" group at the air/water interface of the sodium fluoride (NaF) solutions at different concentrations using the interface selective sum-frequency generation vibrational spectroscopy (SFG-VS) in the ssp and ppp polarizations.	Water	115-120	C-X-C motif chemokine ligand 8	Homo sapiens	155-158
25399172-3	2014	In this report, we present the measurement of changes of the orientational angle of the "free OH" group at the air/water interface of the sodium fluoride (NaF) solutions at different concentrations using the interface selective sum-frequency generation vibrational spectroscopy (SFG-VS) in the ssp and ppp polarizations.	Sodium Fluoride	138-153	C-X-C motif chemokine ligand 8	Homo sapiens	155-158
25399172-6	2014	These results provide quantitative molecular details of the ion effects of the NaF salt on the structure of the water molecules at the top-most layer of the air/water interface, even though both the Na(+) cation and the F(-) anion are believed to be among the most excluded ions from the air/water interface.	Water	112-117	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
25399172-6	2014	These results provide quantitative molecular details of the ion effects of the NaF salt on the structure of the water molecules at the top-most layer of the air/water interface, even though both the Na(+) cation and the F(-) anion are believed to be among the most excluded ions from the air/water interface.	Water	161-166	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
25399172-6	2014	These results provide quantitative molecular details of the ion effects of the NaF salt on the structure of the water molecules at the top-most layer of the air/water interface, even though both the Na(+) cation and the F(-) anion are believed to be among the most excluded ions from the air/water interface.	Water	161-166	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
25014275-6	2014	We observed that PGE2 decreased tumor necrosis factor-alpha (TNF-alpha) production evoked by poly(I:C), whereas PGE2 potentiated poly(I:C)-triggered interleukin-8 (IL-8) production.	Dinoprostone	112-116	C-X-C motif chemokine ligand 8	Homo sapiens	149-162
25014275-6	2014	We observed that PGE2 decreased tumor necrosis factor-alpha (TNF-alpha) production evoked by poly(I:C), whereas PGE2 potentiated poly(I:C)-triggered interleukin-8 (IL-8) production.	Dinoprostone	112-116	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
25452730-7	2014	Using human bronchial epithelial cells, we further show that CS extract (CSE) sequentially activated NADPH oxidase (NADPH oxidase activity, 1.9-fold increase), increased intracellular levels of ROS (3.0-fold increase), activated both MAPKs and NF-kappaB, and induced interleukin-8 (IL-8; 8.2-fold increase); all these CSE-induced events were inhibited by pretreatment with EPA.	Cesium	61-63	C-X-C motif chemokine ligand 8	Homo sapiens	267-280
25452730-7	2014	Using human bronchial epithelial cells, we further show that CS extract (CSE) sequentially activated NADPH oxidase (NADPH oxidase activity, 1.9-fold increase), increased intracellular levels of ROS (3.0-fold increase), activated both MAPKs and NF-kappaB, and induced interleukin-8 (IL-8; 8.2-fold increase); all these CSE-induced events were inhibited by pretreatment with EPA.	Cesium	61-63	C-X-C motif chemokine ligand 8	Homo sapiens	282-286
25452730-8	2014	Our findings suggest a novel role for EPA in alleviating the oxidative stress and lung inflammation induced by subchronic CS exposure in vivo and in suppressing the CSE-induced IL-8 in vitro via its antioxidant function and by inhibiting MAPKs/NF-kappaB signaling.	Eicosapentaenoic Acid	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
25432084-4	2014	Therefore, the aim of this study was to evaluate, in the human lung adenocarcinoma cell line GLC-82, the effects of a 24-hour treatment with simvastatin on hydrogen peroxide (H2O2)-induced changes in cell viability, ERK phosphorylation, matrix metalloproteinase (MMP) expression, innate immunity signaling, NF-kappaB activation and IL-8 secretion.	Hydrogen Peroxide	156-173	C-X-C motif chemokine ligand 8	Homo sapiens	332-336
25432084-7	2014	Our results show that simvastatin (30 muM) significantly (P &lt;0.01) inhibited the proliferative effect of H2O2 (0.5 mM) and its stimulatory actions on ERK1/2 phosphorylation, NF-kappaB activation and IL-8 production.	Simvastatin	22-33	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
25432084-7	2014	Our results show that simvastatin (30 muM) significantly (P &lt;0.01) inhibited the proliferative effect of H2O2 (0.5 mM) and its stimulatory actions on ERK1/2 phosphorylation, NF-kappaB activation and IL-8 production.	Hydrogen Peroxide	108-112	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
25089799-7	2014	Bcl3 expression is regulated by bortezomib (BZ)-mediated proteasome inhibition, and BZ inhibits Bcl3 recruitment to its target promoters, resulting in decreased expression of cIAP1 and cIAP2, but increased expression of IL-8 and IL-17.	Bortezomib	84-86	C-X-C motif chemokine ligand 8	Homo sapiens	220-224
25390653-5	2014	Simplexide induces a concentration- and time-dependent release of IL-6, CXCL8, TNF-alpha and IL-10 and increases the expression of IL6, CXCL8 and IL10 mRNA.	simplexide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	72-77
25390653-5	2014	Simplexide induces a concentration- and time-dependent release of IL-6, CXCL8, TNF-alpha and IL-10 and increases the expression of IL6, CXCL8 and IL10 mRNA.	simplexide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	136-141
25352548-3	2014	In human epithelial DLD-1 and monocytic Mono Mac 6 cells resveratrol decreased the expression of iNOS, IL-8 and TNF-alpha by reducing mRNA stability without inhibition of the promoter activity.	Resveratrol	57-68	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
25352548-10	2014	Finally, resveratrol incubation enhanced its intra-cellular binding to the IL-8, iNOS and TNF-alpha mRNA.	Resveratrol	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
24629538-12	2014	Activated proinflammatory pathways, in particular, IL-8 and IL-1beta, were positively correlated with alcohol consumption and alcohol-craving scores.	Alcohols	102-109	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
24629538-12	2014	Activated proinflammatory pathways, in particular, IL-8 and IL-1beta, were positively correlated with alcohol consumption and alcohol-craving scores.	Alcohols	126-133	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
25261480-5	2014	Vizantin induced the release of IL-8 when HEK293T cells were transiently cotransfected with TLR-4 and MD-2, but not when they were transfected with TLR-4 or MD-2 alone or with TLR-2 or TLR-2/MD-2.	6,6'-bis-O-(3-nonyldodecanoyl)-alpha,alpha'-trehalose	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
25288184-5	2014	Synthetic modifications of the quinazoline scaffold at the 2 and 4 positions revealed trends in structure-activity relationships with respect to TLR dependent production of the NF-kappaB associated cytokine IL-8 in human peripheral blood mononuclear cells, as well as IL-6 in mouse antigen presenting cells.	Quinazolines	31-42	C-X-C motif chemokine ligand 8	Homo sapiens	207-211
24796797-5	2014	We found that BP IgG stimulated IL-6 and IL-8 release from HaCaT cells and that non-toxic doses of 17-DMAG inhibited this IL-8, but not IL-6 secretion in a dose- and time-dependent fashion.	17-(dimethylaminoethylamino)-17-demethoxygeldanamycin	99-106	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
25255717-9	2014	RESULTS: Fibrocytes did not affect ASMC proliferation and expression of TGF-beta1, eotaxin, alpha-SMA and MLCK; however, ASMC production of IL-8 and IL-6 was increased in the co-culture and transwell culture by FC.	asmc	121-125	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
25255717-10	2014	ASMC treated with FCCM were immunopositive for IL-8/IL-6 and produced more IL-8/IL-6.	asmc	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
25255717-10	2014	ASMC treated with FCCM were immunopositive for IL-8/IL-6 and produced more IL-8/IL-6.	asmc	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
25255717-10	2014	ASMC treated with FCCM were immunopositive for IL-8/IL-6 and produced more IL-8/IL-6.	fccm	18-22	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
25255717-10	2014	ASMC treated with FCCM were immunopositive for IL-8/IL-6 and produced more IL-8/IL-6.	fccm	18-22	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
25255717-11	2014	Furthermore, siRNA silencing of NF-kappaB-p65 or ERK1/2 in transwell cultures of asthmatic ASMC with normal subject FC decreased IL-8 and IL-6 production.	asmc	91-95	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
25255717-12	2014	CONCLUSIONS AND CLINICAL RELEVANCE: Fibrocytes promoted IL-8 and IL-6 production by ASMC, demonstrating a proinflammatory role for FC and a possible mechanism of the inflammatory phenotype in asthma.	asmc	84-88	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
25673551-4	2014	In BV the overgrowth of anaerobes produces noxious substances like polyamines and other compounds that trigger the release of pro-inflammatory cytokines interleukin (IL)-1 beta and IL-8.	Polyamines	67-77	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
24890258-0	2014	Zerumbone suppresses IL-1beta-induced cell migration and invasion by inhibiting IL-8 and MMP-3 expression in human triple-negative breast cancer cells.	zerumbone	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
24610641-3	2014	We found that expression of the tumor-promoting cytokines, IL-8 and VEGF, induced by hypoxia (&lt;1% O2) and deferoxamine (a hypoxia mimetic) was significantly attenuated in PPARdelta-deficient HCT116 colon cancer cells.	Oxygen	101-103	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
24610641-3	2014	We found that expression of the tumor-promoting cytokines, IL-8 and VEGF, induced by hypoxia (&lt;1% O2) and deferoxamine (a hypoxia mimetic) was significantly attenuated in PPARdelta-deficient HCT116 colon cancer cells.	Deferoxamine	109-121	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
24691111-6	2014	In all, 3"-, 4-, and 6"-galactosyllactoses of cHMOSs account for specific immunomodulation of polyinosinic:polycytodylic acid-induced IL-8 levels.	polycytodylic acid	107-125	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
25134454-6	2014	By blocking the translocation of nuclear factor kappaB to the nucleus, carotenoids are able to interact with the nuclear factor kappaB pathway and thus inhibit the downstream production of inflammatory cytokines, such as interleukin-8 or prostaglandin E2.	Carotenoids	71-82	C-X-C motif chemokine ligand 8	Homo sapiens	221-234
25958540-1	2014	The purpose of this study was to investigate the biocompatibility of Ti-30Nb-7Ta alloy surface decorated with TiO2 nanotubes by anodization in an electrolyte containing 1 M H3PO4 and 0.8 wt.% NaF with an applied voltage of 10 V for 2 h. The anodization was carried out using a scanning potentiostat.	SCHEMBL3705488	77-80	C-X-C motif chemokine ligand 8	Homo sapiens	192-195
25958540-1	2014	The purpose of this study was to investigate the biocompatibility of Ti-30Nb-7Ta alloy surface decorated with TiO2 nanotubes by anodization in an electrolyte containing 1 M H3PO4 and 0.8 wt.% NaF with an applied voltage of 10 V for 2 h. The anodization was carried out using a scanning potentiostat.	titanium dioxide	110-114	C-X-C motif chemokine ligand 8	Homo sapiens	192-195
25175786-8	2014	Following the paclitaxel treatment, a decreased apoptosis and G2 phase ratio, an increased cell migration ratio, and an increased production of IL-8 were found in MyD88-overexpressed A549 cells.	Paclitaxel	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
24924589-4	2014	We show that I-BET151 is a potent, selective inhibitor of a number of NF-kB target genes involved in induction of inflammation and cell cycle regulation and downregulates production of cytokines such as IL-6 and IL-8.	GSK1210151A	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	212-216
25522414-6	2014	RESULTS: We found that venlafaxine and EPA were anti-inflammatory: venlafaxine decreased IL-6, with a trend for decreases of IL-8 and IP-10, while EPA decreased the levels of IL-6, IL-15, IL-1RA, and IP-10.	Venlafaxine Hydrochloride	23-34	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
25705372-0	2014	Downregulation of IL-8, ECP, and total IgE in the tears of patients with atopic keratoconjunctivitis treated with rebamipide eyedrops.	rebamipide	114-124	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
25522414-6	2014	RESULTS: We found that venlafaxine and EPA were anti-inflammatory: venlafaxine decreased IL-6, with a trend for decreases of IL-8 and IP-10, while EPA decreased the levels of IL-6, IL-15, IL-1RA, and IP-10.	Eicosapentaenoic Acid	39-42	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
25705372-4	2014	In the current study we examined the effect of rebamipide eyedrops on the level of interleukin-8 (IL-8), eosinophil cationic protein (ECP), and total IgE on the ocular surface.	rebamipide	47-57	C-X-C motif chemokine ligand 8	Homo sapiens	83-96
25705372-7	2014	The level of IL-8, ECP, and total IgE in the tears of AKC patients was reduced significantly 4-6 weeks after the start of rebamipide treatment.	rebamipide	122-132	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
25288725-3	2014	The molecular basis of biological activation of CIPKs relies on the calcium-dependent interaction of a self-inhibitory NAF motif with a particular CBL, the phosphorylation of the activation loop by upstream kinases, and the subsequent phosphorylation of the CBL by the CIPK.	Calcium	68-75	C-X-C motif chemokine ligand 8	Homo sapiens	119-122
25279810-1	2014	Highly selective and sensitive fluorescent probes with a quaternary ammonium moiety have been rationally designed and developed for fast and sensitive fluorescence detection of fluoride ion (F(-) from NaF, not TBAF) in aqueous solution and living cells.	quaternary ammonium	57-76	C-X-C motif chemokine ligand 8	Homo sapiens	201-204
25279810-1	2014	Highly selective and sensitive fluorescent probes with a quaternary ammonium moiety have been rationally designed and developed for fast and sensitive fluorescence detection of fluoride ion (F(-) from NaF, not TBAF) in aqueous solution and living cells.	Fluorides	177-185	C-X-C motif chemokine ligand 8	Homo sapiens	201-204
25288725-8	2014	Taken all together, we postulate the basis for a conserved calcium-dependent NAF-mediated regulation of CIPKs and a variable regulation by upstream kinases.	Calcium	59-66	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
24965369-0	2014	Increased expression of dopamine receptors in synovial fibroblasts from patients with rheumatoid arthritis: inhibitory effects of dopamine on interleukin-8 and interleukin-6.	Dopamine	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	142-155
25323788-5	2014	The inflammatory-related cytokines interleukin (IL)-1beta, IL-6 and IL-8 were detected after pretreatment with the alpha1/beta2-AR blockers phentolamine/propranolol, both in vitro and in vivo.	Phentolamine	140-152	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
25150062-7	2014	HDE-induced IL-6, and IL-8 release was significantly lower in cells that were pretreated with 8-Br-cAMP (P &lt; 0.05).	8-Bromo Cyclic Adenosine Monophosphate	94-103	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
25303153-5	2014	Fluctuating glucose concentrations maximally upregulated TLR4 but not TLR2 expression with increased NF-kB activation, IL-8 and ICAM-1 expression.	Glucose	12-19	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
25190815-6	2014	Interestingly, gene silencing of STIM1 or Orai1 also interrupts the activation of calcineurin/nuclear factor of activated T-cells (NFAT) pathway and the production of interleukin 8 triggered by histamine in HUVECs.	Histamine	194-203	C-X-C motif chemokine ligand 8	Homo sapiens	167-180
25107704-8	2014	Instead, archazolid caused endoplasmic reticulum (ER) stress response visualized by increased BiP expression and accumulation of IL-8 (and TNF-alpha) at the ER, indicating a perturbation of protein secretion.	archazolid	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
25275309-3	2014	Exposure of cells to sphingosine 1-phosphate induced pro-inflammatory responses characterized by interleukin-6, interleukin-8, and cyclooxygenase-2 up-regulations, as observed by ELISA and Western blot.	sphingosine 1-phosphate	21-44	C-X-C motif chemokine ligand 8	Homo sapiens	112-125
25056289-6	2014	Furthermore, as little as 5 muM L-K6 significantly inhibited lipopolysaccharide (LPS)- and interleukin-1beta-induced productions of interleukin-8 and tumor necrosis factor-alpha from THP-1 monocytic cells.	l-k6	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	132-177
24965369-8	2014	SFs from patients with RA, in comparison with those from patients with OA, showed increased expression of dopamine receptors D1 and D5 , and exogenous dopamine strongly inhibited the production of IL-8 in patients with RA.	SFS	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
25023990-11	2014	L+E+P also inhibits the angiogenic factors interleukin-8 and vascular endothelial growth factor as well as their induced signaling pathways in ECs.	l+e+p	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	43-56
25272089-5	2014	The results showed that MAG suppressed TNF-alpha-induced chemokine (including CXCL8, CX3CL1, and CXCL16) mRNA expression in HMEC-1 cells, in a dose-dependent manner, and reduced the secretion of these chemokines in culture supernatant.	mag	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	78-83
25062958-7	2014	Exposure to spermine NONOate, 8-bromo-cGMP, or sildenafil (a phosphodiesterase type 5 inhibitor) also increased the expression of beta-catenin-dependent transcripts, IL-8, and cyclin D1.	Sildenafil Citrate	47-57	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
25218171-8	2014	In conclusion, ROS activate NF-kappaB and IL-8 induction in DSCR1-transfected cells in a calcium-dependent manner, which is augmented by IL-1beta since IL-1beta increases calcium and ROS levels in the cells.	Calcium	171-178	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
25042033-8	2014	Comparatively stronger associations were observed between nitrite, eosinophil cationic protein, leukotrienes C/D/E4 and interleukin-8 in sputum.	Nitrites	58-65	C-X-C motif chemokine ligand 8	Homo sapiens	120-133
25042033-8	2014	Comparatively stronger associations were observed between nitrite, eosinophil cationic protein, leukotrienes C/D/E4 and interleukin-8 in sputum.	Leukotrienes	96-108	C-X-C motif chemokine ligand 8	Homo sapiens	120-133
25111853-2	2014	However, a previous study showed that dexamethasone inhibited interleukin 8 (IL-8) expression by promoting IL-8 mRNA decay, which implies a posttranscriptional regulation.	Dexamethasone	38-51	C-X-C motif chemokine ligand 8	Homo sapiens	62-75
25111853-2	2014	However, a previous study showed that dexamethasone inhibited interleukin 8 (IL-8) expression by promoting IL-8 mRNA decay, which implies a posttranscriptional regulation.	Dexamethasone	38-51	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
25111853-2	2014	However, a previous study showed that dexamethasone inhibited interleukin 8 (IL-8) expression by promoting IL-8 mRNA decay, which implies a posttranscriptional regulation.	Dexamethasone	38-51	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
25111853-3	2014	Nevertheless, by which mechanism dexamethasone destabilized IL-8 mRNA was unclear.	Dexamethasone	33-46	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
25062958-7	2014	Exposure to spermine NONOate, 8-bromo-cGMP, or sildenafil (a phosphodiesterase type 5 inhibitor) also increased the expression of beta-catenin-dependent transcripts, IL-8, and cyclin D1.	spermine nitric oxide complex	12-28	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
25062958-7	2014	Exposure to spermine NONOate, 8-bromo-cGMP, or sildenafil (a phosphodiesterase type 5 inhibitor) also increased the expression of beta-catenin-dependent transcripts, IL-8, and cyclin D1.	8-bromocyclic GMP	30-42	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
25063444-6	2014	In addition, IL-22 conferred resistance to 5-FU and OXA by inducing IL-8 autocrine expression through STAT3 activation.	Fluorouracil	43-47	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
25218171-0	2014	Reactive oxygen species mediate IL-8 expression in Down syndrome candidate region-1-overexpressed cells.	Reactive Oxygen Species	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
25218171-8	2014	In conclusion, ROS activate NF-kappaB and IL-8 induction in DSCR1-transfected cells in a calcium-dependent manner, which is augmented by IL-1beta since IL-1beta increases calcium and ROS levels in the cells.	Reactive Oxygen Species	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
25218171-8	2014	In conclusion, ROS activate NF-kappaB and IL-8 induction in DSCR1-transfected cells in a calcium-dependent manner, which is augmented by IL-1beta since IL-1beta increases calcium and ROS levels in the cells.	Calcium	89-96	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
25111853-6	2014	So, we speculated that dexamethasone destabilized IL-8 mRNA by upregulating TTP expression.	Dexamethasone	23-36	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
25111853-7	2014	Here, we report that dexamethasone reduced IL-8 expression through destabilizing IL-8 mRNA in human pulmonary microvascular endothelial cells (HPMECs).	Dexamethasone	21-34	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
25111853-7	2014	Here, we report that dexamethasone reduced IL-8 expression through destabilizing IL-8 mRNA in human pulmonary microvascular endothelial cells (HPMECs).	Dexamethasone	21-34	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
25016235-6	2014	Compared to naive platelet supernatants, APS had a higher level of various cytokines, such as IL8, IL17, PDGF and VEGF.	aps	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	94-97
25478290-9	2014	Reduction of MUC18 serine phosphorylation by inhibiting ERK activity was associated with less production of IL-8 following polyI:C stimulation.	Serine	19-25	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
25478290-9	2014	Reduction of MUC18 serine phosphorylation by inhibiting ERK activity was associated with less production of IL-8 following polyI:C stimulation.	Poly I-C	123-130	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
24648302-8	2014	In contrast, the extent of reduction in serum IL-8 was significantly greater with placebo versus curcuminoids (p = 0.012).	curcuminoids	97-109	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
25942827-4	2014	Formation of the nanotubular oxide surface structure was achieved initially on the Ti-25Ta-xZr alloys by anodization in a 1 M H3PO4 electrolyte containing 0.8 wt.% NaF at room temperature, using a potentiostat.	Oxides	29-34	C-X-C motif chemokine ligand 8	Homo sapiens	164-167
24754833-0	2014	Calcium phosphate particles induce interleukin-8 expression in a human gingival epithelial cell line via the nuclear factor-kappaB signaling pathway.	calcium phosphate	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	35-48
24754833-3	2014	The authors examined the effect of nano/microsized calcium phosphate particles, which may be generated in the process of early precipitation and/or dissolution of calcium phosphate mineral, on the expression of interleukin (IL)-8 in human gingival epithelial cells.	calcium phosphate	51-68	C-X-C motif chemokine ligand 8	Homo sapiens	211-229
25110916-2	2014	The yield of the corresponding Hiyama coupling products is high up to around 90% in water and isopropanol under an ambient atmosphere in the presence of KOH and NaF.	Water	84-89	C-X-C motif chemokine ligand 8	Homo sapiens	161-164
25074943-6	2014	RESULTS: At days 1 and 3, both groups showed a similar inflammatory response; fluticasone produced lower levels of interleukin-8 compared with budesonide (P &lt; .01).	Fluticasone	78-89	C-X-C motif chemokine ligand 8	Homo sapiens	115-128
25035127-7	2014	H2S ratio was positively correlated with St. George"s Respiratory Questionnaire score, sputum neutrophils and IL-6 and IL-8 levels in sputum and serum (p&lt;0.01) but inversely correlated with sputum macrophages (%), FEV1%predicted and FEV1/FVC (p&lt;0.01).	Hydrogen Sulfide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
25268596-0	2014	ZFC3H1, a zinc finger protein, modulates IL-8 transcription by binding with celastramycin A, a potential immune suppressor.	celastramycin A	76-91	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
25268596-1	2014	Celastramycin A, a small molecule that inhibits the production of antibacterial peptides in an ex vivo culture system of Drosophila, suppresses the TNFalpha-mediated induction of IL-8 in mammalian cells.	celastramycin A	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
24997298-4	2014	CS-treated MM6 cells released significant amounts of IL-8 and TNF-alpha into the culture supernatant.	Cesium	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
25110916-2	2014	The yield of the corresponding Hiyama coupling products is high up to around 90% in water and isopropanol under an ambient atmosphere in the presence of KOH and NaF.	2-Propanol	94-105	C-X-C motif chemokine ligand 8	Homo sapiens	161-164
25090483-1	2014	An efficient method for the synthesis of phosphoric fluoride via oxidative coupling between hydrophosphine oxide and NaF is reported.	phosphoric fluoride	41-60	C-X-C motif chemokine ligand 8	Homo sapiens	117-120
25257976-8	2014	RESULTS: Sirolimus significantly suppressed the LPS-induced expression of MCP-1, IL-8, RANTES, MIP-1alpha, and MIP-1beta in the THP-1 cells and human primary monocytes.	Sirolimus	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
25257976-11	2014	CONCLUSION: Sirolimus downregulates the expression of chemokines in monocytes, including MCP-1, RANTES, IL-8, MIP-1alpha, and MIP-1beta, by inhibiting the NF-kappaB-p65 and MAPK-p38 signalling pathways.	Sirolimus	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
25090483-1	2014	An efficient method for the synthesis of phosphoric fluoride via oxidative coupling between hydrophosphine oxide and NaF is reported.	hydrophosphine oxide	92-112	C-X-C motif chemokine ligand 8	Homo sapiens	117-120
25238390-8	2014	In human fetal membranes and myometrium, nobiletin significantly decreased LPS-stimulated expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6 and IL-8) and MMP-9 expression and pro-MMP-9 secretion.	nobiletin	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
25100733-6	2014	A cluster of AU-rich elements in the 3"-UTR of IL8 was essential to the APOBEC1-mediated increase in IL8 production.	Gold	13-15	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
25100733-6	2014	A cluster of AU-rich elements in the 3"-UTR of IL8 was essential to the APOBEC1-mediated increase in IL8 production.	Gold	13-15	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
25254627-2	2014	Here we demonstrate that short-term glutamine restriction triggers an endoplasmic reticulum (ER) stress response that leads to production of the pro-inflammatory chemokine, interleukin-8 (IL-8).	Glutamine	36-45	C-X-C motif chemokine ligand 8	Homo sapiens	173-186
25254627-2	2014	Here we demonstrate that short-term glutamine restriction triggers an endoplasmic reticulum (ER) stress response that leads to production of the pro-inflammatory chemokine, interleukin-8 (IL-8).	Glutamine	36-45	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
25254627-3	2014	Glutamine deprivation-induced ER stress triggers colocalization of autophagosomes, lysosomes and the Golgi into a subcellular structure whose integrity is essential for IL-8 secretion.	Glutamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
25254627-4	2014	The stimulatory effect of glutamine restriction on IL-8 production is attributable to depletion of tricarboxylic acid cycle intermediates.	Glutamine	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
25254627-4	2014	The stimulatory effect of glutamine restriction on IL-8 production is attributable to depletion of tricarboxylic acid cycle intermediates.	Tricarboxylic Acids	99-117	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
25254627-5	2014	The protein kinase, mTOR, is also colocalized with the lysosomal membrane clusters induced by glutamine deprivation, and inhibition of mTORC1 activity abolishes both endomembrane reorganization and IL-8 secretion.	Glutamine	94-103	C-X-C motif chemokine ligand 8	Homo sapiens	198-202
25243587-5	2014	Activation of P2Y6 receptor by its natural ligand, UDP, or its specific agonist, MRS 2693, led to the production of two proinflammatory cytokines, interleukin (IL)-6 and IL-8.	Uridine Diphosphate	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
25234616-9	2014	The immunomodulatory effects of BAP were confirmed by lower levels of IL-1beta, IL-8, and a lower WBC count in the supplemented group in comparison with the control group.	benzylaminopurine	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
25193250-11	2014	CONCLUSIONS: Regarding the results of our in vitro study, the risk of further demineralization was significantly reduced with the use of TiF(4) and NaF after bleaching with 38% HP.	Hydrogen Peroxide	177-179	C-X-C motif chemokine ligand 8	Homo sapiens	148-151
25243101-8	2014	After Ra-223 therapy initiation her bone pain improved, with corresponding decrease in tumor markers and mixed response in (18)F-FDG PET/CT and (18)F-NaF bone PET/CT.	Radium-223	6-12	C-X-C motif chemokine ligand 8	Homo sapiens	150-153
25193250-13	2014	In the case of an intra-oral acidic exposure, the use of topical 1.5% TiF(4) and 2.1% NaF agents might be beneficial after bleaching with 38% HP.	Hydrogen Peroxide	142-144	C-X-C motif chemokine ligand 8	Homo sapiens	86-89
24928308-7	2014	Furthermore we could observe an increased expression and secretion of pro-inflammatory cytokines like interleukin (IL)-6, IL-8 and MCP-1 (2.5-, 2.4- and 1.5-fold, respectively) by the sDPP4 treatment.	sdpp4	184-189	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
24553997-5	2014	Heamatoxylin &amp; eosin staining of acne lesions demonstrated reductions in inflammation and immunohistochemical staining intensity for interleukin-8.	heamatoxylin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	137-150
24553997-5	2014	Heamatoxylin &amp; eosin staining of acne lesions demonstrated reductions in inflammation and immunohistochemical staining intensity for interleukin-8.	Eosine Yellowish-(YS)	19-24	C-X-C motif chemokine ligand 8	Homo sapiens	137-150
25229003-0	2014	Prostaglandin E2 Induces IL-6 and IL-8 Production by the EP Receptors/Akt/NF-kappaB Pathways in Nasal Polyp-Derived Fibroblasts.	Dinoprostone	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
25229003-1	2014	PURPOSE: Interleukin 6 (IL-6) and IL-8 participate in the pathogenesis of chronic rhinosinusitis with nasal polyps, and their levels are increased by prostaglandin E2 (PGE2) in different cell types.	Dinoprostone	150-166	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
25229003-1	2014	PURPOSE: Interleukin 6 (IL-6) and IL-8 participate in the pathogenesis of chronic rhinosinusitis with nasal polyps, and their levels are increased by prostaglandin E2 (PGE2) in different cell types.	Dinoprostone	168-172	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
25229003-2	2014	The purposes of this study were to determine whether PGE2 has any effect on the increase in the levels of IL-6 and IL-8 in nasal polyp-derived fibroblasts (NPDFs) and subsequently investigate the possible mechanism of this effect.	Dinoprostone	53-57	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
25229003-5	2014	To determine the signaling pathway for the expression of PGE2-induced IL-6 and IL-8, PGE2 was treated with Akt and NF-kappaB inhibitors in NPDFs.	Dinoprostone	57-61	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
25229003-5	2014	To determine the signaling pathway for the expression of PGE2-induced IL-6 and IL-8, PGE2 was treated with Akt and NF-kappaB inhibitors in NPDFs.	Dinoprostone	85-89	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
25229003-9	2014	RESULTS: PGE2 significantly increased the mRNA and protein expression levels of IL-6 and IL-8 in NPDFs.	Dinoprostone	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
25229003-12	2014	The Akt and NF-kappaB inhibitors significantly blocked PGE2-induced expression of IL-6 and IL-8.	Dinoprostone	55-59	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
25229003-15	2014	These results suggest that signaling pathway for IL-6 and IL-8 expression induced by PGE2 might be a useful therapeutic target for the treatment of nasal polyposis.	Dinoprostone	85-89	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
25016365-7	2014	RESULTS: Irbesartan reduced concentrations of IL-6, IL-8, CCL2, CXCL5, OPG, OPN and CXCL16 in both atheroma and primary vascular cell culture supernatants.	Irbesartan	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
24928308-11	2014	Additionally, the sDPP4-induced upregulation of IL-6 and IL-8 could completely be prevented by the PAR2 silencing.	sdpp4	18-23	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
25237168-8	2014	With dexamethasone, upregulation of PGE2, IL-6 and IL-8 was suppressed.	Dexamethasone	5-18	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
25426154-2	2014	Therefore, the aim of this study was to investigate fluoride release from three GIs before and after exposure to sodium fluoride (NaF) and acidulated phosphate fluoride (APF).	Fluorides	52-60	C-X-C motif chemokine ligand 8	Homo sapiens	130-133
24821440-6	2014	In human kidney tubule cells, GB88 inhibited cytokine secretion (IL6, IL8, GM-CSF, TNF-alpha) mediated by PAR2.	GB88	30-34	C-X-C motif chemokine ligand 8	Homo sapiens	70-73
25183586-4	2014	This study was designed to determine whether cobalt induces a similar inflammatory response to LPS by promoting the expression of IL-8 and CXCL10.	Cobalt	45-51	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
25183586-6	2014	Cobalt-treated macrophages showed a 60-fold increase in IL-8 mRNA, and an eightfold increase in production of the mature chemokine (both p &lt; 0.001); expression of the CXCL10 gene and protein was also significantly increased by cobalt (both p &lt; 0.001).	Cobalt	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
25183586-7	2014	Experiments were also performed in the presence of CLI-095, a TLR4-specific antagonist which abrogated the cobalt-mediated increase in IL-8 and CXCL10 expression.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	51-58	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
25183586-7	2014	Experiments were also performed in the presence of CLI-095, a TLR4-specific antagonist which abrogated the cobalt-mediated increase in IL-8 and CXCL10 expression.	Cobalt	107-113	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
25183586-9	2014	These pathways result in increased production of IL-8 and CXCL10, and may be implicated in pseudotumour formation following metal-on-metal replacement.	Metals	124-129	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
25183586-9	2014	These pathways result in increased production of IL-8 and CXCL10, and may be implicated in pseudotumour formation following metal-on-metal replacement.	Metals	133-138	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
25426154-2	2014	Therefore, the aim of this study was to investigate fluoride release from three GIs before and after exposure to sodium fluoride (NaF) and acidulated phosphate fluoride (APF).	Sodium Fluoride	113-128	C-X-C motif chemokine ligand 8	Homo sapiens	130-133
24925806-6	2014	While several inhibitors are available for caspase-1 blocking experiments, in this study we show effects of two commonly used caspase inhibitors: z-VAD-fmk and ac-YVAD-cmk on secretion of pro-inflammatory cytokines: IL-1beta, TNFalpha, IL-8 and IL-6 in whole blood stimulated with LPS.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	146-155	C-X-C motif chemokine ligand 8	Homo sapiens	236-240
24558180-6	2014	We also observed 12% and 8% increases in IL-8 associated with an IQR increase in NO2 exposure in lag 3 and over the year before sampling, respectively.	Nitrogen Dioxide	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
24980968-9	2014	Iron chelation by excess Ent or Ybt significantly increased Lcn2-induced secretion of IL-8, IL-6, and CCL20.	Iron	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
24925806-6	2014	While several inhibitors are available for caspase-1 blocking experiments, in this study we show effects of two commonly used caspase inhibitors: z-VAD-fmk and ac-YVAD-cmk on secretion of pro-inflammatory cytokines: IL-1beta, TNFalpha, IL-8 and IL-6 in whole blood stimulated with LPS.	ac-yvad	160-167	C-X-C motif chemokine ligand 8	Homo sapiens	236-240
24925806-7	2014	We demonstrate ac-YVAD-cmk is a specific caspase-1 inhibitor resulting in pronounced decreases in IL-1beta and less suppression of TNFalpha, IL-6 and IL-8, while pan-caspase inhibitor, z-VAD-fmk, only weakly suppressed Il-1beta while acting strongly on the other three cytokines.	ac-yvad	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
24874926-0	2014	Continued decline of aqueous interleukin-8 after multiple intravitreal injections of ganciclovir for cytomegalovirus retinitis.	Ganciclovir	85-96	C-X-C motif chemokine ligand 8	Homo sapiens	29-42
27526527-11	2014	The inhibitory effect by sodium fluoride (NaF) was 5-25% decrease after 24 hours.	Sodium Fluoride	25-40	C-X-C motif chemokine ligand 8	Homo sapiens	42-45
25284569-8	2014	Production of IL8 by Phenytoin induced gingival fibroblasts in children was decreased compared to adults (P = 0.02).	Phenytoin	21-30	C-X-C motif chemokine ligand 8	Homo sapiens	14-17
25284569-9	2014	CONCLUSION: Phenytoin induced gingival fibroblasts of children produce more amounts of IL1beta, PGE2, IL6, TGFbeta and IL8 as compared to adults" fibroblasts.	Phenytoin	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	119-122
25208282-3	2014	Sodium fluoride labeled with fluorine 18 (sodium fluoride F 18 [(18)F-NaF]) is a positron-emitting radiopharmaceutical first introduced several decades ago for skeletal imaging.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	70-73
25208282-3	2014	Sodium fluoride labeled with fluorine 18 (sodium fluoride F 18 [(18)F-NaF]) is a positron-emitting radiopharmaceutical first introduced several decades ago for skeletal imaging.	Fluorine	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	70-73
24894820-7	2014	The SIRT1 activator resveratrol enhanced S. pneumoniae-induced gene expression of hBD2 but decreased IL-8 mRNA levels.	Resveratrol	20-31	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
24894820-8	2014	Blockade of SIRT1 activity by the SIRT1 inhibitors nicotinamide reduced S. pneumoniae-induced hBD2 mRNA expression but increased its stimulatory effects on IL-8 mRNA.	Niacinamide	51-63	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
25157974-11	2014	Finally, there is a significant correlation between the levels of IL-10, IL-4, and IL-8 and formic acid (p&lt;0.05).	formic acid	92-103	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
25208282-3	2014	Sodium fluoride labeled with fluorine 18 (sodium fluoride F 18 [(18)F-NaF]) is a positron-emitting radiopharmaceutical first introduced several decades ago for skeletal imaging.	sodium fluoride f	42-59	C-X-C motif chemokine ligand 8	Homo sapiens	70-73
24904980-0	2014	Calcium signaling and beta2-adrenergic receptors regulate 1-nitropyrene induced CXCL8 responses in BEAS-2B cells.	Calcium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
24904980-0	2014	Calcium signaling and beta2-adrenergic receptors regulate 1-nitropyrene induced CXCL8 responses in BEAS-2B cells.	1-nitropyrene	58-71	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
24904980-2	2014	In the present study we have investigated the mechanisms of CXCL8 (IL-8) responses induced by 1-nitropyrene (1-NP) in human bronchial epithelial BEAS-2B cells, with focus on the possible importance of Ca(2+)-signaling and activation of beta2-adrenergic receptors (beta2AR).	1-nitropyrene	94-107	C-X-C motif chemokine ligand 8	Homo sapiens	60-65
24904980-2	2014	In the present study we have investigated the mechanisms of CXCL8 (IL-8) responses induced by 1-nitropyrene (1-NP) in human bronchial epithelial BEAS-2B cells, with focus on the possible importance of Ca(2+)-signaling and activation of beta2-adrenergic receptors (beta2AR).	1-nitropyrene	94-107	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
24904980-3	2014	Ca(2+)-chelator treatment obliterated 1-NP-induced CXCL8 (IL-8) responses.	1-nitropyrene	38-42	C-X-C motif chemokine ligand 8	Homo sapiens	51-56
24904980-3	2014	Ca(2+)-chelator treatment obliterated 1-NP-induced CXCL8 (IL-8) responses.	1-nitropyrene	38-42	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
25048521-0	2014	Determination of the Al2O3 content in NaF-AlF3-CaF2-Al2O3 melts at 950  C by Raman spectroscopy.	Aluminum Oxide	21-26	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
25148049-4	2014	This study tested the hypothesis that azithromycin treatment, as an add-on to standard medication, would significantly reduce airway neutrophil and neutrophils chemokine (CXCL8) levels, as well as bacterial load.	Azithromycin	38-50	C-X-C motif chemokine ligand 8	Homo sapiens	171-176
25148049-12	2014	Azithromycin treatment resulted in a non-significant reduction in sputum neutrophil proportion, CXCL8 levels and bacterial load.	Azithromycin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	96-101
25148049-15	2014	CONCLUSIONS: In stable COPD with neutrophilic bronchitis, add-on azithromycin therapy showed a trend to reduced severe exacerbations sputum neutrophils, CXCL8 levels and bacterial load.	Azithromycin	65-77	C-X-C motif chemokine ligand 8	Homo sapiens	153-158
25048521-5	2014	In addition, we discuss two quantitative models to determine the alumina content from the Raman spectra of the molten NaF-AlF3-CaF2-Al2O3 electrolytes.	Aluminum Oxide	65-72	C-X-C motif chemokine ligand 8	Homo sapiens	118-121
25048521-6	2014	Univariate and multivariate approaches are applied to determine both the COx (alumina content) and the CR (NaF/AlF3 molar ratio) by Raman spectroscopy without referring to an additional internal reference of intensity.	Chromium	103-105	C-X-C motif chemokine ligand 8	Homo sapiens	107-110
25090413-7	2014	In vitro, exposure of human ameloblast-lineage cells to micromolar levels of both NaF and AlF3 led to a significantly increase in SATB1 protein content, but not levels of Satb1 mRNA, suggesting a fluoride-induced mechanism protecting SABT1 from degradation.	Fluorides	196-204	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
24976128-6	2014	Villiaumite (NaF) was found to be the dominant fluoride species in the cladding waste and natrophosphate (Na7F[PO4]2   19H2O) was the dominant species in the blended waste.	Sodium Fluoride	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
24577419-14	2014	CONCLUSION: Using NaF-PET osteometabolic changes of CBA and implant-bone-interfaces can be monitored.	cba	52-55	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
24844442-1	2014	Amorphous silica nanoparticles (SiNPs) have previously been shown to induce marked cytokine (interleukin-6; IL-6 and interleukin-8; CXCL8/IL-8) responses independently of particle uptake in human bronchial epithelial BEAS-2B cells.	Silicon Dioxide	10-16	C-X-C motif chemokine ligand 8	Homo sapiens	117-130
24844442-1	2014	Amorphous silica nanoparticles (SiNPs) have previously been shown to induce marked cytokine (interleukin-6; IL-6 and interleukin-8; CXCL8/IL-8) responses independently of particle uptake in human bronchial epithelial BEAS-2B cells.	Silicon Dioxide	10-16	C-X-C motif chemokine ligand 8	Homo sapiens	132-137
24844442-1	2014	Amorphous silica nanoparticles (SiNPs) have previously been shown to induce marked cytokine (interleukin-6; IL-6 and interleukin-8; CXCL8/IL-8) responses independently of particle uptake in human bronchial epithelial BEAS-2B cells.	Silicon Dioxide	10-16	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
24844442-7	2014	Overall, our results indicate that Si50-induced IL-6 and CXCL8 responses in BEAS-2B cells were regulated through combined activation of several pathways, including NF-kappaBeta and p38/TACE/TGF-alpha/EGFR signalling.	si50	35-39	C-X-C motif chemokine ligand 8	Homo sapiens	57-62
25108547-5	2014	RESULTS: Exposure of lung epithelial cells to HCl resulted in increased expression of intercellular adhesion molecule-1 (ICAM-1) and production of interleukin (IL)-8 at 24 h. The expression of the epithelial markers E-cadherin decreased while the mesenchymal markers vimentin and alpha-smooth muscle actin (alpha-SMA) increased at 24 h and remained high at 48 h. The addition of monocytes augmented the profiles of lower expression of epithelial markers and higher mesenchymal markers accompanied by increased collagen deposition.	Hydrochloric Acid	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	147-165
24515724-7	2014	Furthermore, bufalin attenuated the TNF-alpha-induced interleukin-1beta (IL-1beta), IL-6, and IL-8 production in RAFLSs in a concentration-dependent manner.	bufalin	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
24779584-5	2014	Expression of IL-8 receptors (CXCR1 and CXCR2) and the LPS receptor TLR4 was similar on neutrophils from young and old subjects, and neutrophils challenged with phorbol-12-myristate-13-acetate (PMA) showed no age-associated differences in ROS or NET production.	Tetradecanoylphorbol Acetate	194-197	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
24779584-5	2014	Expression of IL-8 receptors (CXCR1 and CXCR2) and the LPS receptor TLR4 was similar on neutrophils from young and old subjects, and neutrophils challenged with phorbol-12-myristate-13-acetate (PMA) showed no age-associated differences in ROS or NET production.	Reactive Oxygen Species	239-242	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
24811947-6	2014	The releases of IL-8 from A549 and TNF-alpha from J774A.1 were significantly correlated to PM size, Zeta potential, endotoxin, major metals, and polycyclic aromatic hydrocarbons.	Polycyclic Aromatic Hydrocarbons	145-177	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
24777307-0	2014	Suppressive action of acetate on interleukin-8 production via tubulin-alpha acetylation.	Acetates	22-29	C-X-C motif chemokine ligand 8	Homo sapiens	33-46
24777307-5	2014	Flagellin stimulation induces IL-8 production in epithelial cells and acetate suppresses this IL-8 production via tubulin-alpha acetylation.	Acetates	70-77	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
24374727-4	2014	We used a multiplex protein assay to determine the tumor expression levels of the proangiogenic proteins IL-6, IL-8, bFGF, PDGF-BB and VEGF-A in formalin-fixed paraffin-embedded tumors from the MAX clinical trial patients with available tissue samples.	Formaldehyde	145-153	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
24374727-4	2014	We used a multiplex protein assay to determine the tumor expression levels of the proangiogenic proteins IL-6, IL-8, bFGF, PDGF-BB and VEGF-A in formalin-fixed paraffin-embedded tumors from the MAX clinical trial patients with available tissue samples.	Paraffin	160-168	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
24719336-11	2014	PGE2 receptor antagonists dose-dependently inhibited the release of IL-6, IL-8, and PGE2 by IFP-stimulated FLS.	Dinoprostone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
24608042-10	2014	These findings indicated that TAMs may facilitate PTC cell metastasis through CXCL8 and its paracrine interaction with CXCR1/2.	tams	30-34	C-X-C motif chemokine ligand 8	Homo sapiens	78-83
25297357-9	2014	IL-8 expression had negative correlation with MS components especially with triglyceride and total cholesterol (r=0.5, P&lt;0.001).	Triglycerides	76-88	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
25297357-9	2014	IL-8 expression had negative correlation with MS components especially with triglyceride and total cholesterol (r=0.5, P&lt;0.001).	Cholesterol	99-110	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
24859059-9	2014	Thalidomide analogs 1 and 2 demonstrated more potent activity to suppress expression levels of IL-6, IL-8, TNF-alpha, VEGF165, and MMP-2 than thalidomide.	Thalidomide	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
24750048-8	2014	YB, TA and YBTA inhibited TNFalpha by 57.57%, 59.09% and 68.93% and IL-8 production by 48.76%, 47.92% and 51.13% in P. acne-stimulated THP-1 cells, respectively.	Ytterbium	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
24750048-8	2014	YB, TA and YBTA inhibited TNFalpha by 57.57%, 59.09% and 68.93% and IL-8 production by 48.76%, 47.92% and 51.13% in P. acne-stimulated THP-1 cells, respectively.	Tantalum	4-6	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
24750048-8	2014	YB, TA and YBTA inhibited TNFalpha by 57.57%, 59.09% and 68.93% and IL-8 production by 48.76%, 47.92% and 51.13% in P. acne-stimulated THP-1 cells, respectively.	ybta	11-15	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
24729102-0	2014	Effects of alpha lipoic acid supplementation on serum levels of IL-8 and TNF-alpha in patient with ESRD undergoing hemodialysis.	Thioctic Acid	11-28	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
24957686-0	2014	Pristimerin, a natural anti-tumor triterpenoid, inhibits LPS-induced TNF-alpha and IL-8 production through down-regulation of ROS-related classical NF-kappaB pathway in THP-1 cells.	pristimerin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
24957686-3	2014	The results showed that pristimerin inhibited the production of TNF-alpha and IL-8 in a dose-dependent manner.	pristimerin	24-35	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
25201625-11	2014	Furthermore, AhR-ligands alone at high concentrations induced a moderate CXCL8-response, without affecting CCL5, but suppressed both CXCL8 and CCL5-responses by Poly I:C. CONCLUSION: AhR and Arnt may differentially and independently regulate chemokine-responses induced by both inhaled pollutants and pulmonary infections.	Poly I	161-167	C-X-C motif chemokine ligand 8	Homo sapiens	133-138
25069913-8	2014	Gln also up-regulated expression of interleukin-6, interleukin-8, MCP-1, MIP-3alpha, CCL2, CCL20, and CXCL1.	Glutamine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
25058399-10	2014	LY294002, a PI3K inhibitor, inhibited HPV-16 oncoprotein-induced activation of Akt, P70S6K, and P85S6K, expression of HIF-1alpha, VEGF, and IL-8, and in vitro angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
25201625-7	2014	Yet, constitutively active unligated AhR suppressed both CXCL8 and CCL5, as shown by siRNA knock-down and the AhR antagonist alpha-naphthoflavone.	alpha-naphthoflavone	125-145	C-X-C motif chemokine ligand 8	Homo sapiens	57-62
25013374-8	2014	Interestingly, treatment with AGP increased the expression and secretion of endogenous interleukin (IL)-6 and IL-8; however, this effect was inhibited when HCAECs were cotreated with cPA or the synthetic peroxisome proliferator-activator receptor gamma (PPARgamma) antagonist T0070907.	cpa	183-186	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
25051116-11	2014	CONCLUSIONS: Out of ten analyzed cytokines and nitric oxide, IL-8 correlated with the observed increase in mitochondrial respiration.	Nitric Oxide	47-59	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
25089120-7	2014	IPE secreted IL-8 or MCP-1 in response to Pam3CSK4.3HCl, Poly(I:C), LPS and MALP-2, whereas RPE produced IL-8 only after Poly(I:C), LPS or MALP-2 treatment.	ipe	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
25089120-7	2014	IPE secreted IL-8 or MCP-1 in response to Pam3CSK4.3HCl, Poly(I:C), LPS and MALP-2, whereas RPE produced IL-8 only after Poly(I:C), LPS or MALP-2 treatment.	poly	57-61	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
25089120-8	2014	TLR inhibitors (OxPAPC, CI-095 and chloroquine) blocked IL-8 secretion in Poly(I:C), LPS or MALP-2-treated IPE and RPE.	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	16-22	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
25089120-8	2014	TLR inhibitors (OxPAPC, CI-095 and chloroquine) blocked IL-8 secretion in Poly(I:C), LPS or MALP-2-treated IPE and RPE.	ci-095	24-30	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
25089120-8	2014	TLR inhibitors (OxPAPC, CI-095 and chloroquine) blocked IL-8 secretion in Poly(I:C), LPS or MALP-2-treated IPE and RPE.	Chloroquine	35-46	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
25089120-8	2014	TLR inhibitors (OxPAPC, CI-095 and chloroquine) blocked IL-8 secretion in Poly(I:C), LPS or MALP-2-treated IPE and RPE.	ipe	107-110	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
25010330-7	2014	Among patients with ANS dysregulation or PE, the expression frequency of CD4+Foxp3+ increased markedly after milrinone treatment, and was associated with reduction of plasma levels IL-6, IL-8 and IL-10.	Milrinone	109-118	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
24896229-6	2014	Our lead compound, CX797, inhibited IL8-mediated cAMP signaling and receptor degradation while specifically up-regulating IL8-mediated beta-arrestin-2 recruitment.	Cyclic AMP	49-53	C-X-C motif chemokine ligand 8	Homo sapiens	36-39
24792438-0	2014	Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes.	lysophosphatidic acid	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
32481974-0	2014	Interleukin-8 gene silencing on pancreatic cancer cells using biodegradable polymer nanoplexes.	Polymers	76-83	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
24792438-1	2014	Lysophosphatidic acid (LPA) is a pleiotropic lipid mediator that promotes motility, survival, and the synthesis of chemokines/cytokines such as interleukin-8 (IL-8) and interleukin-6 by human fibroblast-like synoviocytes from patients with rheumatoid arthritis (RAFLS).	lysophosphatidic acid	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	144-157
24792436-3	2014	Tylvalosin treatment markedly decreased IL-8, IL-6, IL-1beta, PGE2, TNF-alpha and NO levels in vitro and in vivo.	tylvalosin	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
24844181-5	2014	We show that histone tail acetylation status is modified following DEX administration, through distinct and alternative mechanisms at the promoters of interleukin-8 and interleukin-23.	Dexamethasone	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	151-164
24792438-1	2014	Lysophosphatidic acid (LPA) is a pleiotropic lipid mediator that promotes motility, survival, and the synthesis of chemokines/cytokines such as interleukin-8 (IL-8) and interleukin-6 by human fibroblast-like synoviocytes from patients with rheumatoid arthritis (RAFLS).	lysophosphatidic acid	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
24792438-1	2014	Lysophosphatidic acid (LPA) is a pleiotropic lipid mediator that promotes motility, survival, and the synthesis of chemokines/cytokines such as interleukin-8 (IL-8) and interleukin-6 by human fibroblast-like synoviocytes from patients with rheumatoid arthritis (RAFLS).	lysophosphatidic acid	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	144-157
24792438-1	2014	Lysophosphatidic acid (LPA) is a pleiotropic lipid mediator that promotes motility, survival, and the synthesis of chemokines/cytokines such as interleukin-8 (IL-8) and interleukin-6 by human fibroblast-like synoviocytes from patients with rheumatoid arthritis (RAFLS).	lysophosphatidic acid	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
24792438-2	2014	In those cells LPA was reported to induce IL-8 secretion through activation of various signaling pathways including p38 mitogen-activated protein kinase (p38 MAPK), p42/44 MAPK, and Rho kinase.	lysophosphatidic acid	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
24792438-4	2014	The silencing of MSKs with small-interfering RNAs and the pharmacological inhibitor of MSKs SB747651A shows a role for both MSK1 and MSK2 in LPA-mediated phosphorylation of CREB at Ser-133 and secretion of IL-8 and MCP-1.	SB 747651A	92-101	C-X-C motif chemokine ligand 8	Homo sapiens	206-210
24792438-4	2014	The silencing of MSKs with small-interfering RNAs and the pharmacological inhibitor of MSKs SB747651A shows a role for both MSK1 and MSK2 in LPA-mediated phosphorylation of CREB at Ser-133 and secretion of IL-8 and MCP-1.	lysophosphatidic acid	141-144	C-X-C motif chemokine ligand 8	Homo sapiens	206-210
24792438-4	2014	The silencing of MSKs with small-interfering RNAs and the pharmacological inhibitor of MSKs SB747651A shows a role for both MSK1 and MSK2 in LPA-mediated phosphorylation of CREB at Ser-133 and secretion of IL-8 and MCP-1.	Serine	181-184	C-X-C motif chemokine ligand 8	Homo sapiens	206-210
24792438-5	2014	Whereas CREB inhibitors have off target effects and increased LPA-mediated IL-8 secretion, the silencing of CREB1 with short hairpin RNA significantly reduced LPA-induced chemokine production in RAFLS.	lysophosphatidic acid	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
25091484-7	2014	Cholesterol crystal activation of the NF-kappaB pathway also leads to increased IL-6 and IL-8 expression.	Cholesterol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
24597536-2	2014	Here, we investigated the role of three different NSAIDs (naproxen, ibuprofen and oxaprozin) on neutrophil responses to CXCL8 and C5a.	Naproxen	58-66	C-X-C motif chemokine ligand 8	Homo sapiens	120-125
24597536-2	2014	Here, we investigated the role of three different NSAIDs (naproxen, ibuprofen and oxaprozin) on neutrophil responses to CXCL8 and C5a.	Ibuprofen	68-77	C-X-C motif chemokine ligand 8	Homo sapiens	120-125
24597536-2	2014	Here, we investigated the role of three different NSAIDs (naproxen, ibuprofen and oxaprozin) on neutrophil responses to CXCL8 and C5a.	Oxaprozin	82-91	C-X-C motif chemokine ligand 8	Homo sapiens	120-125
24597536-11	2014	Pretreatment with different NSAIDs prevented C5a-induced integrin (CD11b) up-regulation, while only ibuprofen reduced CXCL8-induced CD11b up-regulation.	Ibuprofen	100-109	C-X-C motif chemokine ligand 8	Homo sapiens	118-123
24172227-0	2014	Short-term exposure to oleandrin enhances responses to IL-8 by increasing cell surface IL-8 receptors.	oleandrin	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
24172227-0	2014	Short-term exposure to oleandrin enhances responses to IL-8 by increasing cell surface IL-8 receptors.	oleandrin	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
24172227-4	2014	Here, we studied the effects of the plant glycoside oleandrin on responses to IL-8 in a human monocytic cell line.	Glycosides	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
24172227-4	2014	Here, we studied the effects of the plant glycoside oleandrin on responses to IL-8 in a human monocytic cell line.	oleandrin	52-61	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
24172227-10	2014	Pulse exposure to oleandrin increased expression of IL-8 receptors and chemotaxis, release of enzymes and activation of NF-kappaB, NFAT and AP-1 along with increased IL-8-mediated calcineurin activation, and wound healing.	oleandrin	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
24172227-10	2014	Pulse exposure to oleandrin increased expression of IL-8 receptors and chemotaxis, release of enzymes and activation of NF-kappaB, NFAT and AP-1 along with increased IL-8-mediated calcineurin activation, and wound healing.	oleandrin	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
24172227-12	2014	CONCLUSIONS AND IMPLICATIONS: Short-term (1 h; pulse) exposure to a toxic glycoside oleandrin, enhanced biological responses to IL-8 in monocytic cells, without cytoxicity.	Glycosides	74-83	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
24172227-12	2014	CONCLUSIONS AND IMPLICATIONS: Short-term (1 h; pulse) exposure to a toxic glycoside oleandrin, enhanced biological responses to IL-8 in monocytic cells, without cytoxicity.	oleandrin	84-93	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
24048734-0	2014	In oesophageal squamous cells exposed to acidic bile salt medium, omeprazole inhibits IL-8 expression through effects on nuclear factor-kappaB and activator protein-1.	Omeprazole	66-76	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
24925646-5	2014	Leukotriene C4 (LTC4) and LTD4 were used as the agonists to induce IL-8 production and the related changes in signal molecules.	Leukotriene C4	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
24858696-0	2014	Dexamethasone modifies mitomycin C-triggered interleukin-8 secretion in isolated human Tenon"s capsule fibroblasts.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	45-58
24858696-0	2014	Dexamethasone modifies mitomycin C-triggered interleukin-8 secretion in isolated human Tenon"s capsule fibroblasts.	Mitomycin	23-34	C-X-C motif chemokine ligand 8	Homo sapiens	45-58
24858696-6	2014	Recombinant interleukin-8 (IL-8) was used to verify the effect of MMC-related IL-8 secretion.	Mitomycin	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	12-25
24858696-6	2014	Recombinant interleukin-8 (IL-8) was used to verify the effect of MMC-related IL-8 secretion.	Mitomycin	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
24858696-6	2014	Recombinant interleukin-8 (IL-8) was used to verify the effect of MMC-related IL-8 secretion.	Mitomycin	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
24858696-13	2014	In contrast, DEX reversed the MMC-retarded cell proliferation rate (p = 0.036) and repressed MMC-related IL-8 secretion by 33.5% at 3 dpt (p = 0.003).	Dexamethasone	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
24858696-19	2014	We conclude that DEX reversed the MMC-inhibited HTF cell proliferation via diminishing the MMC-induced IL-8 secretion, which resulted from a late-phase upregulation of the PPARgamma and Bcl-xL.	Dexamethasone	17-20	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
24858696-19	2014	We conclude that DEX reversed the MMC-inhibited HTF cell proliferation via diminishing the MMC-induced IL-8 secretion, which resulted from a late-phase upregulation of the PPARgamma and Bcl-xL.	Mitomycin	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
24858696-19	2014	We conclude that DEX reversed the MMC-inhibited HTF cell proliferation via diminishing the MMC-induced IL-8 secretion, which resulted from a late-phase upregulation of the PPARgamma and Bcl-xL.	Mitomycin	91-94	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
24925646-9	2014	The ERK1/2 inhibitor U0126 inhibited Egr-1 and IL-8 expression as well as IL-8 release, but the JNK and p38 inhibitors did not have the inhibitory effects.	U 0126	21-26	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
24925646-9	2014	The ERK1/2 inhibitor U0126 inhibited Egr-1 and IL-8 expression as well as IL-8 release, but the JNK and p38 inhibitors did not have the inhibitory effects.	U 0126	21-26	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
24874745-10	2014	Furthermore, orbital tissue was obtained from a patient with active GO, and the effect of dasatinib on the expression levels of HAS2-, CCL2-, IL6-, and IL8-mRNA expression was examined by real-time quantitative PCR.	Dasatinib	90-99	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
24048734-9	2014	RESULTS: Acidic bile salt medium caused oesophageal epithelial cells to express IL-8 mRNA and protein by activating the IL-8 promoter through NF-kappaB and AP-1 binding.	Bile Acids and Salts	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
24874745-14	2014	In orbital tissue from active GO, dasatinib significantly suppressed HAS2-, CCL2-, IL6- and IL8-mRNA levels.	Dasatinib	34-43	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
24048734-9	2014	RESULTS: Acidic bile salt medium caused oesophageal epithelial cells to express IL-8 mRNA and protein by activating the IL-8 promoter through NF-kappaB and AP-1 binding.	Bile Acids and Salts	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
24048734-10	2014	Omeprazole inhibited that acidic bile salt-stimulated IL-8 expression by blocking the nuclear translocation of p65 (an NF-kappaB subunit), and by blocking the binding of p65, c-jun and c-fos (AP-1 subunits) to the IL-8 promoter.	Omeprazole	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
24048734-10	2014	Omeprazole inhibited that acidic bile salt-stimulated IL-8 expression by blocking the nuclear translocation of p65 (an NF-kappaB subunit), and by blocking the binding of p65, c-jun and c-fos (AP-1 subunits) to the IL-8 promoter.	Omeprazole	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
24048734-10	2014	Omeprazole inhibited that acidic bile salt-stimulated IL-8 expression by blocking the nuclear translocation of p65 (an NF-kappaB subunit), and by blocking the binding of p65, c-jun and c-fos (AP-1 subunits) to the IL-8 promoter.	Bile Acids and Salts	33-42	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
24048734-10	2014	Omeprazole inhibited that acidic bile salt-stimulated IL-8 expression by blocking the nuclear translocation of p65 (an NF-kappaB subunit), and by blocking the binding of p65, c-jun and c-fos (AP-1 subunits) to the IL-8 promoter.	Bile Acids and Salts	33-42	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
24048734-12	2014	CONCLUSIONS: In oesophageal squamous epithelial cells, omeprazole inhibits IL-8 expression through effects on NF-kappaB and AP-1 that are entirely independent of effects on gastric acid secretion.	Omeprazole	55-65	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
25244845-8	2014	In addition, the photocatalytic experiment with the addition of NaF indicated that the adsorption of PFOA was of primary importance for the photocatalytic decomposition.	perfluorooctanoic acid	101-105	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
24819422-1	2014	UNLABELLED: The National Oncologic PET Registry prospectively assessed the impact of PET with (18)F-sodium fluoride (NaF PET) on intended management of Medicare patients with suspected or known osseous metastasis.	f-sodium fluoride	98-115	C-X-C motif chemokine ligand 8	Homo sapiens	117-120
24788377-10	2014	Similarly, IL-8 levels were markedly increased in the ventilated DL and collapsed NDL after OLV compared with those before OLV in the sevoflurane group, whereas there was no significant change in IL-8 levels in the propofol group in the ventilated DL and collapsed NDL before and after OLV.	Sevoflurane	134-145	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
24662521-7	2014	High-glucose conditions further enhanced the tumour-driven macrophage enrichment and associated interleukin (IL)-6 and IL-8 cytokine levels.	high-glucose	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
24833491-7	2014	In this work, we provide preliminary evidence that (18)F-NaF PET imaging can be used to detect breast cancer by targeting the hydroxyapatite lattice within the tumor microenvironment with high specificity and soft-tissue contrast-to-background ratio while delineating tumors from inflammation.	Durapatite	126-140	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
24857974-7	2014	The chondroprotective action of diacerein in mechanically stimulated cells was mediated by a decrease in interleukin-8 (IL-8), fibronectin-1 (FN-1), collagen type I (Col 1) and MMP-1 expression levels, respectively.	diacerein	32-41	C-X-C motif chemokine ligand 8	Homo sapiens	105-118
24406841-7	2014	Treatment with ruxolitinib also resulted in the reduction of key cytokines (tumor necrosis factor alpha, interleukin-4 (IL-4), IL-6 and IL-8) and induction of interferon-gamma.	ruxolitinib	15-26	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
24857974-7	2014	The chondroprotective action of diacerein in mechanically stimulated cells was mediated by a decrease in interleukin-8 (IL-8), fibronectin-1 (FN-1), collagen type I (Col 1) and MMP-1 expression levels, respectively.	diacerein	32-41	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
25030398-3	2014	Fluorine-18-sodium fluoride (18F-NaF) is a highly sensitive PET tracer used as a marker of osteoblastic abnormalities.	fluorine-18-sodium fluoride	0-27	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
24847057-7	2014	UDP-Glc also stimulated keratinocyte migration, proliferation, and IL-8 expression, supporting a notion that UDP-Glc signals for epidermal inflammation, enhanced hyaluronan synthesis as an integral part of it.	Uridine Diphosphate Glucose	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
24998372-4	2014	RESULTS: Treatment with formoterol and budesonide 72 h before and after RV14 infection reduced RV14 titers and cytokine concentrations, including interleukin (IL)-1beta, IL-6 and IL-8, in supernatants and viral RNA within cells.	Formoterol Fumarate	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
24998372-4	2014	RESULTS: Treatment with formoterol and budesonide 72 h before and after RV14 infection reduced RV14 titers and cytokine concentrations, including interleukin (IL)-1beta, IL-6 and IL-8, in supernatants and viral RNA within cells.	Budesonide	39-49	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
24847057-7	2014	UDP-Glc also stimulated keratinocyte migration, proliferation, and IL-8 expression, supporting a notion that UDP-Glc signals for epidermal inflammation, enhanced hyaluronan synthesis as an integral part of it.	Uridine Diphosphate Glucose	109-116	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
24918924-5	2014	RESULTS: In HAEC, TLR4 antagonism with eritoran inhibited LPS-induced mRNA expression of IL-6, IL-8, TNFalpha, CCL-2, VCAM and ICAM (P&lt;0.05 for all) and inhibited Ox-PAPC-induced mRNA expression of IL-8 (P&lt;0.05) and IL-6, albeit not to a statistically significant level (p = 0.07).	eritoran	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
24491692-2	2014	Due to an increase of neutrophil mediators in acute myocardial infarction the aim of this study was to establish the effect of oleacein on neutral endopeptidase (NEP) activity and other functions of human neutrophils, such as elastase, MMP-9 and IL-8 production.	oleacein	127-135	C-X-C motif chemokine ligand 8	Homo sapiens	246-250
24491692-4	2014	Oleacein with a concentration of 100 muM inhibited NEP activity, elastase, MMP-9 and IL-8 release from neutrophils by 77.7 +- 2.7%, 21.3 +- 7.8%, 22.7 +- 4.2% and 25.2 +- 5.6%, respectively.	oleacein	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
25002964-6	2014	RESULTS: Probiotic supplementation was associated with decreased LTA (lipoteichoic acid) induced CCL4, CXCL8, IL-1beta and IL-6 responses at 12 months and decreased CCL4 and IL-1beta secretion at 24 months.	lipoteichoic acid	70-87	C-X-C motif chemokine ligand 8	Homo sapiens	103-108
24760988-9	2014	While these results point to potential involvement of PRRs, L-C14 carnitine promoted IL-8 secretion from human epithelial cells (HCT-116) lacking Toll-like receptors (TLR)2 and -4, and did not activate reporter constructs in TLR overexpression cell models.	l-c14 carnitine	60-75	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
24867687-5	2014	The NF-kappaB inhibitor DHMEQ inhibited the production of IL-6 and IL-8 by EOC cell lines.	dehydroxymethylepoxyquinomicin	24-29	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
24918924-5	2014	RESULTS: In HAEC, TLR4 antagonism with eritoran inhibited LPS-induced mRNA expression of IL-6, IL-8, TNFalpha, CCL-2, VCAM and ICAM (P&lt;0.05 for all) and inhibited Ox-PAPC-induced mRNA expression of IL-8 (P&lt;0.05) and IL-6, albeit not to a statistically significant level (p = 0.07).	eritoran	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	201-205
24905361-0	2014	Finding ATF4/p75NTR/IL-8 signal pathway in endothelial-mesenchymal transition by safrole oxide.	safrole oxide	81-94	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
24522860-4	2014	RESULTS: Activation of M3 mAChR with carbachol increased both IL-8 mRNA and protein expression in a concentration-dependent manner.	Carbachol	37-46	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
24704898-1	2014	We investigate whether a novel and inexpensive etching method, H3PO4 + NaF, on titanium could obtain both a lower hydrogen content and superior calcium phosphate deposition performance, while achieving similar surface roughness in comparison with the traditional etching method.	Titanium	79-87	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
24704898-1	2014	We investigate whether a novel and inexpensive etching method, H3PO4 + NaF, on titanium could obtain both a lower hydrogen content and superior calcium phosphate deposition performance, while achieving similar surface roughness in comparison with the traditional etching method.	Hydrogen	114-122	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
24704898-1	2014	We investigate whether a novel and inexpensive etching method, H3PO4 + NaF, on titanium could obtain both a lower hydrogen content and superior calcium phosphate deposition performance, while achieving similar surface roughness in comparison with the traditional etching method.	calcium phosphate	144-161	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
24751922-1	2014	The objective of this study was to locate the functional region responsible for the chemotaxis-inducing activity of flounder interleukin 8 (IL-8), which lacks the glutamic acid-leucine-arginine (ELR) motif essential for the induction of neutrophil migration by mammalian IL-8.	glutamic acid-leucine-arginine	163-193	C-X-C motif chemokine ligand 8	Homo sapiens	125-138
24751922-1	2014	The objective of this study was to locate the functional region responsible for the chemotaxis-inducing activity of flounder interleukin 8 (IL-8), which lacks the glutamic acid-leucine-arginine (ELR) motif essential for the induction of neutrophil migration by mammalian IL-8.	glutamic acid-leucine-arginine	163-193	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
24751922-8	2014	We propose that residue 6 (leucine) at the N-terminus is important for the chemotaxis-inducing activity of flounder IL-8.	Leucine	27-34	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
24716633-0	2014	Increased IL-8 production in human bronchial epithelial cells after exposure to azithromycin-pretreated Pseudomonas aeruginosa in vitro.	Azithromycin	80-92	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
24716633-4	2014	The results showed that AZM-pretreated P. aeruginosa (PAO1 and six different clinical isolates) significantly stimulated HBE cells to release IL-8, a crucial pro-inflammatory cytokine.	Azithromycin	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
24716633-6	2014	Our results suggest that AZM-pretreated P. aeruginosa could indirectly exacerbate pro-inflammation by inducing IL-8 production in HBEs.	Azithromycin	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
24522860-6	2014	M3 mAChR-mediated IL-8 expression was almost completely inhibited by the NF-kappaB inhibitor BAY11-7082 and, to a lesser extent, by U0126, SB203580, and SP600125, which are inhibitors for ERK1/2, p38, and JNK, respectively.	SB 203580	139-147	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
24522860-6	2014	M3 mAChR-mediated IL-8 expression was almost completely inhibited by the NF-kappaB inhibitor BAY11-7082 and, to a lesser extent, by U0126, SB203580, and SP600125, which are inhibitors for ERK1/2, p38, and JNK, respectively.	pyrazolanthrone	153-161	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
24522860-7	2014	Furthermore, M3 mAChR-mediated NF-kappaB activation and IL-8 expression were simultaneously attenuated by the PKC inhibitor calphostin C, whereas PMA, a PKC activator, mimicked the effects of carbachol, inducing IL-8 expression.	calphostin C	124-136	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
24522860-7	2014	Furthermore, M3 mAChR-mediated NF-kappaB activation and IL-8 expression were simultaneously attenuated by the PKC inhibitor calphostin C, whereas PMA, a PKC activator, mimicked the effects of carbachol, inducing IL-8 expression.	calphostin C	124-136	C-X-C motif chemokine ligand 8	Homo sapiens	212-216
24522860-5	2014	Elevated IL-8 expression was completely antagonized by atropine, 4-DAMP and tiotropium.	Atropine	55-63	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
24522860-6	2014	M3 mAChR-mediated IL-8 expression was almost completely inhibited by the NF-kappaB inhibitor BAY11-7082 and, to a lesser extent, by U0126, SB203580, and SP600125, which are inhibitors for ERK1/2, p38, and JNK, respectively.	3-(4-methylphenylsulfonyl)-2-propenenitrile	93-103	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
24522860-6	2014	M3 mAChR-mediated IL-8 expression was almost completely inhibited by the NF-kappaB inhibitor BAY11-7082 and, to a lesser extent, by U0126, SB203580, and SP600125, which are inhibitors for ERK1/2, p38, and JNK, respectively.	U 0126	132-137	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
24851271-8	2014	At 24 h treatment of hPDLSCs with BzATP it enhanced the release of the pro-inflammatory agents IL8 and CCL20, without influencing cell viability.	BzATP	34-39	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
24816468-2	2014	Our study involves evaluating the extent to which the pre-treatment of saliva samples with an anionic detergent - sodium dodecyl sulphate (SDS) - improved detection levels for IL-8 and EGF.	Sodium Dodecyl Sulfate	114-137	C-X-C motif chemokine ligand 8	Homo sapiens	176-188
24816468-2	2014	Our study involves evaluating the extent to which the pre-treatment of saliva samples with an anionic detergent - sodium dodecyl sulphate (SDS) - improved detection levels for IL-8 and EGF.	Sodium Dodecyl Sulfate	139-142	C-X-C motif chemokine ligand 8	Homo sapiens	176-188
24816468-6	2014	We found that pre-treatment of samples with SDS significantly increased the detection levels for both EGF (293%) and IL-8 (346%) when compared with PBS-treated pairs (***P&lt;0.001).	Sodium Dodecyl Sulfate	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
24885771-6	2014	In vitro macrophage exposure to representative NP (Fe2O3, Fe3O4, MnFe2O4 and CrOOH) induced the production of a pro-inflammatory secretome (increased production of CXCL-8, IL-1ss, TNF-alpha, CCL-2, -3, -4, and to a lesser extent IL-6, CCL-7 and -22), and all but Fe3O4 NP induce an increased migration of macrophages (Boyden chamber).	Iron(III) oxide	51-56	C-X-C motif chemokine ligand 8	Homo sapiens	164-170
24849681-8	2014	Based on a logistic regression analysis, smoker phosphate mine workers have a higher relative risk than controls to have an increase concentration of some cytokines, especially IL-1beta, IL-6, IL-8, TNF-alpha, and MIP-1beta.	Phosphates	48-57	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
24849681-9	2014	Moreover, the combined effect of smoking and phosphate dusts exposure increases the level of leucocytes as well as the concentration of IL-1beta, IL-6, IL-8, MIP1-beta, and LTB-4.	Phosphates	45-54	C-X-C motif chemokine ligand 8	Homo sapiens	152-156
24559582-9	2014	CONCLUSIONS: Our results suggest that combination therapy with miglitol and sitagliptin improves glycemic control and reduces the circulating protein concentrations of IL-8, sE-selectin, and sVCAM-1 in type 2 diabetic Japanese patients.	Sitagliptin Phosphate	76-87	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
24668612-0	2014	Elevated IL-8, TNF-alpha, and MCP-1 in men with metastatic prostate cancer starting androgen-deprivation therapy (ADT) are associated with shorter time to castration-resistance and overall survival.	adt	114-117	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
25174381-18	2014	Compared with those detected before treatment, the levels of TNF-alpha, IL-6, and IL-8 in serum of group BP at PTH 24 and 48 were significantly decreased (with P values below 0.01).	Benzo(a)pyrene	105-107	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
24879414-11	2014	Angiogenin, IGFBP-1, IL-8, MCP-1, MMP-9, and VEGF mRNA and protein expressions were significantly enhanced in LPA-treated chondrocytes.	lysophosphatidic acid	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
24879414-13	2014	Pretreatment with the Gi/o type G protein inhibitor, pertussis toxin (PTX), and the NF-kB inhibitor, PDTC, significantly inhibited LPA-induced angiogenin, IGFBP-1, IL-8, MCP-1, MMP-9, and VEGF expressions in chondrocytes.	lysophosphatidic acid	131-134	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
24852112-2	2014	These glasses exhibit significant superiority compared with traditional fluorozirconate glass (ZrF4-BaF2-LaF3-AlF3-NaF) because of their higher temperature of glass transition and better resistance to water corrosion.	fluorozirconate	72-87	C-X-C motif chemokine ligand 8	Homo sapiens	115-118
25177524-7	2014	Biliverdin (50 muM) significantly decreased the LPS-mediated gene expression of IL-1beta, IL-6, IFN-gamma, IL-1Ra and IL-8 (P&lt;0.05).	Biliverdine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
24770886-8	2014	In concert with these results, targeting MUC1-C with GO-203 suppresses IL-8/CXCR1 expression and disrupts the formation of established mammospheres.	(arginine)9-cysteinyl-glutaminyl-cysteinyl-arginyl-arginyl-lysyl-asparagine	53-59	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
24828117-11	2014	CONCLUSIONS: Out of ten analyzed cytokines and nitric oxide, IL-8 correlated with the observed increase in mitochondrial respiration.	Nitric Oxide	47-59	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
24885771-6	2014	In vitro macrophage exposure to representative NP (Fe2O3, Fe3O4, MnFe2O4 and CrOOH) induced the production of a pro-inflammatory secretome (increased production of CXCL-8, IL-1ss, TNF-alpha, CCL-2, -3, -4, and to a lesser extent IL-6, CCL-7 and -22), and all but Fe3O4 NP induce an increased migration of macrophages (Boyden chamber).	manganese ferrite	65-72	C-X-C motif chemokine ligand 8	Homo sapiens	164-170
24819773-7	2014	Our data indicate that IL-8 induced NETosis is reduced by ascomycin and cyclosporine A, antagonists of the calcineurin pathway, but not following treatment with rapamycin, which utilizes the mTOR pathway.	immunomycin	58-67	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
24819773-7	2014	Our data indicate that IL-8 induced NETosis is reduced by ascomycin and cyclosporine A, antagonists of the calcineurin pathway, but not following treatment with rapamycin, which utilizes the mTOR pathway.	Cyclosporine	72-86	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
24885636-8	2014	Furthermore, cytokines that were secreted by TAMs, such as IL-6 and IL-8, were also significantly increased.	tams	45-49	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
24885771-6	2014	In vitro macrophage exposure to representative NP (Fe2O3, Fe3O4, MnFe2O4 and CrOOH) induced the production of a pro-inflammatory secretome (increased production of CXCL-8, IL-1ss, TNF-alpha, CCL-2, -3, -4, and to a lesser extent IL-6, CCL-7 and -22), and all but Fe3O4 NP induce an increased migration of macrophages (Boyden chamber).	crooh	77-82	C-X-C motif chemokine ligand 8	Homo sapiens	164-170
24885636-9	2014	This response was attenuated by treating TAMs with the KCNN4 channel-specific inhibitor, 1-[(2-chlorophenyl) diphenylmethyl]-1H-pyrazole (TRAM-34), which suggested that KCNN4 channels may be involved in inducing the secretion of IL-6 and IL-8 by TAMs and improving CRC cell invasiveness.	tams	41-45	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
24885636-9	2014	This response was attenuated by treating TAMs with the KCNN4 channel-specific inhibitor, 1-[(2-chlorophenyl) diphenylmethyl]-1H-pyrazole (TRAM-34), which suggested that KCNN4 channels may be involved in inducing the secretion of IL-6 and IL-8 by TAMs and improving CRC cell invasiveness.	TRAM 34	89-136	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
24819773-8	2014	The action of the G protein coupled receptor phospholipase C pathway appears to be essential for the induction of NETs by IL-8, as NETosis was diminished by treatment with either pertussis toxin, a G-protein inhibitor, the phospholipase C inhibitor, U73122, or staurosporine, an inhibitor of protein kinase C. The data regarding the calcineurin antagonists, ascomycin and cyclosporine A, open the possibility to therapeutically suppress or modulate NETosis.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	250-256	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
24819773-8	2014	The action of the G protein coupled receptor phospholipase C pathway appears to be essential for the induction of NETs by IL-8, as NETosis was diminished by treatment with either pertussis toxin, a G-protein inhibitor, the phospholipase C inhibitor, U73122, or staurosporine, an inhibitor of protein kinase C. The data regarding the calcineurin antagonists, ascomycin and cyclosporine A, open the possibility to therapeutically suppress or modulate NETosis.	Staurosporine	261-274	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
24819773-8	2014	The action of the G protein coupled receptor phospholipase C pathway appears to be essential for the induction of NETs by IL-8, as NETosis was diminished by treatment with either pertussis toxin, a G-protein inhibitor, the phospholipase C inhibitor, U73122, or staurosporine, an inhibitor of protein kinase C. The data regarding the calcineurin antagonists, ascomycin and cyclosporine A, open the possibility to therapeutically suppress or modulate NETosis.	immunomycin	358-367	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
24819773-8	2014	The action of the G protein coupled receptor phospholipase C pathway appears to be essential for the induction of NETs by IL-8, as NETosis was diminished by treatment with either pertussis toxin, a G-protein inhibitor, the phospholipase C inhibitor, U73122, or staurosporine, an inhibitor of protein kinase C. The data regarding the calcineurin antagonists, ascomycin and cyclosporine A, open the possibility to therapeutically suppress or modulate NETosis.	Cyclosporine	372-386	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
24885636-9	2014	This response was attenuated by treating TAMs with the KCNN4 channel-specific inhibitor, 1-[(2-chlorophenyl) diphenylmethyl]-1H-pyrazole (TRAM-34), which suggested that KCNN4 channels may be involved in inducing the secretion of IL-6 and IL-8 by TAMs and improving CRC cell invasiveness.	TRAM 34	138-145	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
24885636-13	2014	CONCLUSIONS: Our findings suggested that TAMs participate in the metastasis of CRC induced by PRL-3 through the TNF-alpha mediated secretion of IL-6 and IL-8 in a paracrine manner.	tams	41-45	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
24885871-3	2014	This study examined the effect of linoleate, a member of the n-6 family, on regulation of the palmitate-induced inflammatory cytokine interleukin-8 (IL8) in hepatocytes.	Linoleic Acid	34-43	C-X-C motif chemokine ligand 8	Homo sapiens	134-147
24885871-3	2014	This study examined the effect of linoleate, a member of the n-6 family, on regulation of the palmitate-induced inflammatory cytokine interleukin-8 (IL8) in hepatocytes.	Linoleic Acid	34-43	C-X-C motif chemokine ligand 8	Homo sapiens	149-152
24885871-3	2014	This study examined the effect of linoleate, a member of the n-6 family, on regulation of the palmitate-induced inflammatory cytokine interleukin-8 (IL8) in hepatocytes.	Palmitates	94-103	C-X-C motif chemokine ligand 8	Homo sapiens	134-147
24885871-3	2014	This study examined the effect of linoleate, a member of the n-6 family, on regulation of the palmitate-induced inflammatory cytokine interleukin-8 (IL8) in hepatocytes.	Palmitates	94-103	C-X-C motif chemokine ligand 8	Homo sapiens	149-152
24885871-6	2014	RESULTS: Dose- and time-related changes of IL8 mRNA expression were examined and 9 h treatment with 500 muM palmitate showed the greatest elevation of IL8.	Palmitates	108-117	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
24885871-6	2014	RESULTS: Dose- and time-related changes of IL8 mRNA expression were examined and 9 h treatment with 500 muM palmitate showed the greatest elevation of IL8.	Palmitates	108-117	C-X-C motif chemokine ligand 8	Homo sapiens	151-154
24885871-7	2014	Co-treatment with 500 muM palmitate and 400 muM linoleate significantly suppressed IL8 production below that with palmitate alone in both cells (both mRNA and protein).	Palmitates	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
24885871-7	2014	Co-treatment with 500 muM palmitate and 400 muM linoleate significantly suppressed IL8 production below that with palmitate alone in both cells (both mRNA and protein).	Linoleic Acid	48-57	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
24885871-7	2014	Co-treatment with 500 muM palmitate and 400 muM linoleate significantly suppressed IL8 production below that with palmitate alone in both cells (both mRNA and protein).	Palmitates	114-123	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
24885871-10	2014	Treatment with 400 muM linoleate alone led to IL8 production (5.48 fold change), similar to co-treatment, with no influence on the expression of pJNK/IkBalpha.	Linoleic Acid	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
24885871-12	2014	CONCLUSIONS: Linoleate is a potent regulator of the proinflammatory cytokine IL8 via the JNK and nuclear factor kappa B pathways that are involved in the pathophysiology of NASH, suggesting a future recommendation of dietary management.	Linoleic Acid	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
24788721-9	2014	Immuno-suppressive effects of ZEA were further revealed through the suppression of lipopolysaccharide (LPS)-induced expression of pro-inflammatory cytokines (IL-6, IL-8 and IL-1beta).	Zearalenone	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
24810615-8	2014	Following PZQ treatment there was an increase in the number of participants producing detectable levels of GST-specific cytokines (TNFalpha, IL-6, IL-8, IFNgamma, IL-12p70, IL-13 and IL-23p19) and also a shift in the GST-specific cytokine response towards a more pro-inflammatory phenotype than that observed before treatment.	Praziquantel	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
24806487-5	2014	Via this process we identified three distinct chemical series, xanthines (SB711), quinazolininones (GSK223) and aminobenzothiazoles (GSK966) that selectively inhibited iE-DAP-stimulated IL-8 release via the NOD1 signaling pathway.	Xanthines	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
24806487-5	2014	Via this process we identified three distinct chemical series, xanthines (SB711), quinazolininones (GSK223) and aminobenzothiazoles (GSK966) that selectively inhibited iE-DAP-stimulated IL-8 release via the NOD1 signaling pathway.	sb711	74-79	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
24806487-5	2014	Via this process we identified three distinct chemical series, xanthines (SB711), quinazolininones (GSK223) and aminobenzothiazoles (GSK966) that selectively inhibited iE-DAP-stimulated IL-8 release via the NOD1 signaling pathway.	quinazolininones	82-98	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
24806487-5	2014	Via this process we identified three distinct chemical series, xanthines (SB711), quinazolininones (GSK223) and aminobenzothiazoles (GSK966) that selectively inhibited iE-DAP-stimulated IL-8 release via the NOD1 signaling pathway.	GSK223	100-106	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
24806487-5	2014	Via this process we identified three distinct chemical series, xanthines (SB711), quinazolininones (GSK223) and aminobenzothiazoles (GSK966) that selectively inhibited iE-DAP-stimulated IL-8 release via the NOD1 signaling pathway.	aminobenzothiazoles	112-131	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
24806487-5	2014	Via this process we identified three distinct chemical series, xanthines (SB711), quinazolininones (GSK223) and aminobenzothiazoles (GSK966) that selectively inhibited iE-DAP-stimulated IL-8 release via the NOD1 signaling pathway.	Diaminopimelic Acid	171-174	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
25306677-12	2014	There were no significant differences found in the levels of IL-6 and CRP between RIPC and control groups during the whole study Unexpectedly significant excess concentrations of IL-8 at 24 h were found when RIPC applied during sevoflurane anesthesia: 12.3 (10.6, 14.4) pg/mL in RIPCsevo group vs 6.2 (4.8, 11.1) pg/ml in CONTROLsevo group (p = 0.02).	Sevoflurane	228-239	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
24474597-1	2014	OBJECTIVE: This study investigates whether early dynamic positron emission tomography/computed tomography (edPET/CT) using (18)F-sodium fluoride-((18)F-NaF) is feasible in depicting early phases of radiotracer distribution in patients with chronic osteomyelitis (COM).	Sodium Fluoride	129-144	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
24631175-0	2014	Increased plasma glucose levels after change of recommendation from NaF to citrate blood collection tubes.	Glucose	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
24631175-5	2014	CONCLUSIONS: The change from NaF to citrate tubes caused higher glucose values, and consequently more glucose determinations above the decision limit for diabetes.	Citric Acid	36-43	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
24631175-5	2014	CONCLUSIONS: The change from NaF to citrate tubes caused higher glucose values, and consequently more glucose determinations above the decision limit for diabetes.	Glucose	64-71	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
24631175-5	2014	CONCLUSIONS: The change from NaF to citrate tubes caused higher glucose values, and consequently more glucose determinations above the decision limit for diabetes.	Glucose	102-109	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
24493202-8	2014	Fetuin-A upregulated IL-6 and IL-8, and this was potentiated by palmitate and blocked by CLI-095.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	89-96	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
24413578-12	2014	In multivariate analysis, baseline cholesterol levels and cardiopulmonary bypass duration were significant and independent determinants of the 3-hour postcardiopulmonary bypass increase in concentrations of procalcitonin and interleukin-8, but not of interleukin-6.	Cholesterol	35-46	C-X-C motif chemokine ligand 8	Homo sapiens	225-238
25097896-1	2014	Our aim was to establish an easy and convenient procedure for the preparation of fluorine-18-sodium fluoride ((18)F-NaF) for bone positron emission tomography (PET) during routine (18)F-FDG production using the Explora FDG4 radiochemistry module (EFRM) by single run of Cyclotron with negligible radiation exposure.	fluorine-18-sodium fluoride	81-108	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
24581581-10	2014	In marginal structural models, IL-1beta, IL-6, IL-8 were associated with lower estradiol and progesterone concentrations.	Estradiol	79-88	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
24581581-10	2014	In marginal structural models, IL-1beta, IL-6, IL-8 were associated with lower estradiol and progesterone concentrations.	Progesterone	93-105	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
24413629-1	2014	OBJECTIVE: To investigate whether glutamine deprivation induces expression of inflammatory cytokine interleukin-8 (IL-8) by determining NF-kappaB activity and levels of oxidative indices (ROS, reactive oxygen species; hydrogen peroxide; GSH, glutathione) in fibroblasts isolated from patients with ataxia telangiectasia (A-T).	Glutamine	34-43	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
24413629-0	2014	Glutamine deprivation induces interleukin-8 expression in ataxia telangiectasia fibroblasts.	Glutamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
25097896-1	2014	Our aim was to establish an easy and convenient procedure for the preparation of fluorine-18-sodium fluoride ((18)F-NaF) for bone positron emission tomography (PET) during routine (18)F-FDG production using the Explora FDG4 radiochemistry module (EFRM) by single run of Cyclotron with negligible radiation exposure.	Fluorodeoxyglucose F18	186-189	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
24413629-1	2014	OBJECTIVE: To investigate whether glutamine deprivation induces expression of inflammatory cytokine interleukin-8 (IL-8) by determining NF-kappaB activity and levels of oxidative indices (ROS, reactive oxygen species; hydrogen peroxide; GSH, glutathione) in fibroblasts isolated from patients with ataxia telangiectasia (A-T).	Glutamine	34-43	C-X-C motif chemokine ligand 8	Homo sapiens	100-113
24413629-9	2014	RESULTS: While glutamine deprivation induced IL-8 expression and increased NF-kappaB DNA-binding activity in Mock cells, both processes were decreased by treatment of cells with glutamine or GSH or both glutamine and GSH.	Glutamine	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
24413629-9	2014	RESULTS: While glutamine deprivation induced IL-8 expression and increased NF-kappaB DNA-binding activity in Mock cells, both processes were decreased by treatment of cells with glutamine or GSH or both glutamine and GSH.	Glutamine	178-187	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
25097896-13	2014	The level of Kryptofix-222 (K222) in (18)F-NaF was within the prescribed limit.	cryptating agent 222	13-26	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
24413629-9	2014	RESULTS: While glutamine deprivation induced IL-8 expression and increased NF-kappaB DNA-binding activity in Mock cells, both processes were decreased by treatment of cells with glutamine or GSH or both glutamine and GSH.	Glutathione	191-194	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
24413629-9	2014	RESULTS: While glutamine deprivation induced IL-8 expression and increased NF-kappaB DNA-binding activity in Mock cells, both processes were decreased by treatment of cells with glutamine or GSH or both glutamine and GSH.	Glutamine	178-187	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
24413629-14	2014	MEFs transfected with ATM siRNA and cultured without glutamine showed higher levels of ROS and IL-8 than those transfected with negative control siRNA; increased levels of ROS and IL-8 were suppressed by the treatment of glutamine.	Glutamine	53-62	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
24413629-14	2014	MEFs transfected with ATM siRNA and cultured without glutamine showed higher levels of ROS and IL-8 than those transfected with negative control siRNA; increased levels of ROS and IL-8 were suppressed by the treatment of glutamine.	Glutamine	221-230	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
25097896-13	2014	The level of Kryptofix-222 (K222) in (18)F-NaF was within the prescribed limit.	cryptating agent 222	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
24413629-14	2014	MEFs transfected with ATM siRNA and cultured without glutamine showed higher levels of ROS and IL-8 than those transfected with negative control siRNA; increased levels of ROS and IL-8 were suppressed by the treatment of glutamine.	Glutamine	221-230	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
24413629-15	2014	CONCLUSION: Glutamine deprivation induces ROS production, NF-kappaB activation, and IL-8 expression as well as a reduction in GSH in A-T fibroblasts, all of which are attenuated by glutamine supplementation.	Glutamine	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
24759736-9	2014	RESULT: H2O2 enhanced IL1beta-induced IL-6 and CXCL8 expression in NHBE and BEAS-2B cells whereas H2O2 alone did not have any affect.	Hydrogen Peroxide	8-12	C-X-C motif chemokine ligand 8	Homo sapiens	47-52
24413629-15	2014	CONCLUSION: Glutamine deprivation induces ROS production, NF-kappaB activation, and IL-8 expression as well as a reduction in GSH in A-T fibroblasts, all of which are attenuated by glutamine supplementation.	Glutamine	181-190	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
24589569-5	2014	TET significantly inhibited the induction of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 by phorbol 12-myristate 13-acetate (PMA) plus A23187.	tetrandrine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
24589569-5	2014	TET significantly inhibited the induction of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 by phorbol 12-myristate 13-acetate (PMA) plus A23187.	Tetradecanoylphorbol Acetate	143-174	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
24589569-5	2014	TET significantly inhibited the induction of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 by phorbol 12-myristate 13-acetate (PMA) plus A23187.	Tetradecanoylphorbol Acetate	176-179	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
24589569-9	2014	Furthermore, TET suppressed the expression of TNF-alpha, IL-8, IL-6 and COX-2 through suppression of the ERK1/2, JNK1/2, IkappaBalpha degradation and phosphorylation, and NF-kappaB activation.	tetrandrine	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
24582799-8	2014	RESULTS: Repeated-measures three-way ANOVA (p=0.009) and Tukey"s test showed that CaL pre-rinse followed by NaF rinse significantly decreased surface loss of enamel when performed prior to an erosive challenge in comparison with the condition in which NaF only was used.	calcium lactate	82-85	C-X-C motif chemokine ligand 8	Homo sapiens	252-255
24582799-9	2014	CONCLUSIONS: Pre-rinse with CaL may increase the protection exerted by NaF against erosive wear.	calcium lactate	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
24734646-0	2014	Upconversion luminescence properties of Yb3+ and Tm3+ codoped amorphous fluoride ZrF4-BaF2-LaF3-AlF3-NaF thin film prepared by pulsed laser deposition.	Fluorides	72-80	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
25098981-0	2014	Assessment of serum interleukin-8 as a sensitive serological marker in monitoring the therapeutic effect of levamisole in recurrent aphthous ulcers: a randomized control study.	Levamisole	108-118	C-X-C motif chemokine ligand 8	Homo sapiens	20-33
25098981-1	2014	AIM: The study was designed to evaluate the serum interleukin-8 (IL-8) levels in patients with recurrent aphthous ulcer (RAU) and monitor the immunomodulation and altered IL-8 levels by levamisole before therapy and after levamisole therapy.	Levamisole	186-196	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
25098981-8	2014	Highly significant comparisons were obtained in the serum IL-8 between study and control groups before the onset of levamisole (t = 6.53, P &lt;= 0.001).	Levamisole	116-126	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
25098981-9	2014	IL-8 levels reduced by 72% after levamisole was instituted in RAU patients and comparison was highly significant for before and after levamisole onset (t = 5.54, P &lt;= 0.001).	Levamisole	33-43	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
25098981-9	2014	IL-8 levels reduced by 72% after levamisole was instituted in RAU patients and comparison was highly significant for before and after levamisole onset (t = 5.54, P &lt;= 0.001).	Levamisole	134-144	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
24369896-4	2014	Metal concentrations were measured in sputum supernatant by inductively-coupled plasma mass spectrometry and correlated with sputum inflammatory cell counts, lactate dehydrogenase (LDH) and interleukin (IL)-8 concentrations, atmospheric particulate matter, lung function, clinical status and participant demographics.	Metals	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	190-208
24369896-7	2014	The concentrations of magnesium, iron and zinc positively correlated with IL-8.	Magnesium	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
24369896-7	2014	The concentrations of magnesium, iron and zinc positively correlated with IL-8.	Iron	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
24964617-6	2014	RESULTS: The section of the IL-6, TNF-alpha, IL-1beta and IL-8 were the highest when THP-1 cells were exposed to NiSO4, DNCB and K2Cr2O7 for 6h, PPDA and TDI for 12h.	nickel sulfate	113-118	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
24964617-6	2014	RESULTS: The section of the IL-6, TNF-alpha, IL-1beta and IL-8 were the highest when THP-1 cells were exposed to NiSO4, DNCB and K2Cr2O7 for 6h, PPDA and TDI for 12h.	Dinitrochlorobenzene	120-124	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
24964617-6	2014	RESULTS: The section of the IL-6, TNF-alpha, IL-1beta and IL-8 were the highest when THP-1 cells were exposed to NiSO4, DNCB and K2Cr2O7 for 6h, PPDA and TDI for 12h.	4-(2'-pyridyldithio)benzyldiazoacetate	145-149	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
24964617-6	2014	RESULTS: The section of the IL-6, TNF-alpha, IL-1beta and IL-8 were the highest when THP-1 cells were exposed to NiSO4, DNCB and K2Cr2O7 for 6h, PPDA and TDI for 12h.	Toluene 2,4-Diisocyanate	154-157	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
24554449-0	2014	Transcriptional and posttranscriptional regulation and endocytosis were involved in zinc oxide nanoparticle-induced interleukin-8 overexpression in human bronchial epithelial cells.	Zinc Oxide	84-94	C-X-C motif chemokine ligand 8	Homo sapiens	116-129
24743821-8	2014	Compared with normal cells, the NOD1 and NOD2 agonists, DAP and MDP, successfully increased IL-8 expression respectively (P&lt;0.05).	alpha,beta-diacryloxypropionic acid	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
24743449-6	2014	Since the Epidermal Growth Factor Receptor (EGFR) and reactive oxygen species (ROS) have been implicated in IL-8 release in response to activation of other G protein-coupled receptors, we examined their importance in S1P induced IL-8 release and established that they are not involved.	Reactive Oxygen Species	54-77	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
24743449-6	2014	Since the Epidermal Growth Factor Receptor (EGFR) and reactive oxygen species (ROS) have been implicated in IL-8 release in response to activation of other G protein-coupled receptors, we examined their importance in S1P induced IL-8 release and established that they are not involved.	Reactive Oxygen Species	79-82	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
24824707-0	2014	gamma-Globulin fraction proteins and their metal complexes with copper cations in induction of IL-8 production.	Metals	43-48	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
24824707-0	2014	gamma-Globulin fraction proteins and their metal complexes with copper cations in induction of IL-8 production.	Copper	64-70	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
24824707-1	2014	Plasma gamma-globulin fraction proteins, copper cations, and metal complexes formed by copper cations with human serum gamma-globulin induce the production of up to 4.0 ng/ml IL-8 by human blood cells.	Copper	41-47	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
24824707-1	2014	Plasma gamma-globulin fraction proteins, copper cations, and metal complexes formed by copper cations with human serum gamma-globulin induce the production of up to 4.0 ng/ml IL-8 by human blood cells.	Metals	61-66	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
24824707-1	2014	Plasma gamma-globulin fraction proteins, copper cations, and metal complexes formed by copper cations with human serum gamma-globulin induce the production of up to 4.0 ng/ml IL-8 by human blood cells.	Copper	87-93	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
24743449-0	2014	Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor kappaB in BEAS-2B cells.	sphingosine 1-phosphate	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	38-51
24743449-0	2014	Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor kappaB in BEAS-2B cells.	sphingosine 1-phosphate	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
24743449-0	2014	Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor kappaB in BEAS-2B cells.	sphingosine 1-phosphate	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	38-51
24743449-0	2014	Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor kappaB in BEAS-2B cells.	sphingosine 1-phosphate	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
24743449-2	2014	Sphingosine 1-phosphate (S1P) is a bioactive lipid, increased in the airways of asthmatics, that may trigger the release of the potent neutrophil chemoattractant Interleukin-8 (IL-8) by epithelial cells.	sphingosine 1-phosphate	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	162-175
24743449-2	2014	Sphingosine 1-phosphate (S1P) is a bioactive lipid, increased in the airways of asthmatics, that may trigger the release of the potent neutrophil chemoattractant Interleukin-8 (IL-8) by epithelial cells.	sphingosine 1-phosphate	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
24743449-2	2014	Sphingosine 1-phosphate (S1P) is a bioactive lipid, increased in the airways of asthmatics, that may trigger the release of the potent neutrophil chemoattractant Interleukin-8 (IL-8) by epithelial cells.	sphingosine 1-phosphate	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	162-175
24743449-2	2014	Sphingosine 1-phosphate (S1P) is a bioactive lipid, increased in the airways of asthmatics, that may trigger the release of the potent neutrophil chemoattractant Interleukin-8 (IL-8) by epithelial cells.	sphingosine 1-phosphate	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
24782870-8	2014	STBM derived from preeclamptic placentas up-regulated the cell surface expression of CD54, and stimulated the secretion of the pro-inflammatory interleukin (IL)-6 and IL-8 in a similar, dose-dependent manner as did STBM prepared from normal placentas.	stbm	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
24548972-9	2014	Additionally, the proposed hypothesis is strengthened by the indirect experimental findings indicating that CNTs and fullerenes induce an excessive expression of specific cytokines and chemokines (i.e. IL-8 and MCP1).	Fullerenes	117-127	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
24705919-9	2014	IP-10 release was blocked by a PI3K inhibitor and IL-8 by dexamethasone.	Dexamethasone	58-71	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
24705928-5	2014	A multi-steps binding mode is proposed: (i) the N-loop of CXCL-8 initially binds to the N-terminal domain of receptor CXCR1 driven predominantly by electrostatic interactions; (ii) hydrophobic interactions allow the N-terminal Glu-Leu-Arg (ELR) motif of CXCL-8 to move closer to the extracellular loops of CXCR1; (iii) electrostatic interactions finally dominate the interaction between the N-terminal ELR motif of CXCL-8 and the EC-loops of CXCR1.	Glutamic Acid	227-230	C-X-C motif chemokine ligand 8	Homo sapiens	58-64
24705928-5	2014	A multi-steps binding mode is proposed: (i) the N-loop of CXCL-8 initially binds to the N-terminal domain of receptor CXCR1 driven predominantly by electrostatic interactions; (ii) hydrophobic interactions allow the N-terminal Glu-Leu-Arg (ELR) motif of CXCL-8 to move closer to the extracellular loops of CXCR1; (iii) electrostatic interactions finally dominate the interaction between the N-terminal ELR motif of CXCL-8 and the EC-loops of CXCR1.	leucylarginine	231-238	C-X-C motif chemokine ligand 8	Homo sapiens	58-64
24694877-10	2014	In addition, embelin inhibited the expression of markers of angiogenesis (COX-2, VEGF, VEGFR, and IL-8), and metastasis (MMP-2 and MMP-9) in tumor tissues.	embelin	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
23856970-5	2014	Ambroxol (100 nM) reduced RV14 titers and cytokine concentrations of interleukin (IL)-1beta, IL-6 and IL-8 in the supernatants and RV14 RNA in the cells after RV14 infection, in addition to reducing susceptibility to RV14 infection.	Ambroxol	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
24479526-7	2014	IL-33 increased ERK 1/2 phosphorylation in goblet cells (P &lt; 0.05), and PD98059, a MAPK/ERK kinase inhibitor, attenuated IL-33-stimulated CXCL8/IL-8 secretion from goblet cells (P &lt; 0.001).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	75-82	C-X-C motif chemokine ligand 8	Homo sapiens	141-146
24554449-1	2014	Inhaled zinc oxide nanoparticles (ZnO-NPs) can induce lung inflammation through released inflammatory mediators, such as interleukin 8 (IL-8), from airways.	Zinc Oxide	8-18	C-X-C motif chemokine ligand 8	Homo sapiens	121-134
24479526-7	2014	IL-33 increased ERK 1/2 phosphorylation in goblet cells (P &lt; 0.05), and PD98059, a MAPK/ERK kinase inhibitor, attenuated IL-33-stimulated CXCL8/IL-8 secretion from goblet cells (P &lt; 0.001).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	75-82	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
24554449-1	2014	Inhaled zinc oxide nanoparticles (ZnO-NPs) can induce lung inflammation through released inflammatory mediators, such as interleukin 8 (IL-8), from airways.	Zinc Oxide	8-18	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
24554449-4	2014	The effect of ZnO-NPs on IL-8 mRNA stability was examined using mRNA decay assay.	Zinc Oxide	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
24554449-5	2014	The phagocytosis inhibitor cytochalasin B (CB) was utilized to define the role of endocytosis in ZnO-NP-induced IL-8 expression.	zno-np	97-103	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
24554449-7	2014	Exposure to ZnO-NPs significantly increased the expression of IL-8 mRNA and protein in a dose-dependent manner.	Zinc Oxide	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
24554449-8	2014	Pretreatment with Act D blocked ZnO-NP-induced IL-8 expression.	zno-np	32-38	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
24554449-9	2014	Both NFkappaB and C/EBPbeta transcription factors were required for ZnO-NP-induced IL-8 transcription.	zno-np	68-74	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
24554449-10	2014	mRNA decay assay showed that ZnO-NP stimulation delayed IL-8 mRNA degradation in BEAS-2B cells.	zno-np	29-35	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
24554449-11	2014	Pretreatment of BEAS-2B cells with CB blocked ZnO-NP-induced IL-8 expression by 30 %.	zno-np	46-52	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
24554449-12	2014	Exposure to ZnO-NPs induced IL-8 gene expression through transcriptional activation and mRNA stabilization.	Zinc Oxide	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
24554449-13	2014	Internalization of nanoparticles was partially involved in ZnO-NP-induced IL-8 expression.	zno-np	59-65	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
24226202-9	2014	Furthermore, both gene knockdown and pharmacological inhibition studies showed that COX-2 mediates the TNF-alpha/IL-8 pathway by increasing the production of prostaglandin E2 (PGE2).	Dinoprostone	158-174	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
24521260-5	2014	After treatment of normal human epidermal keratinocytes with TCDD or PCBs, IL-6 and IL-8 production were increased.	Polychlorinated Dibenzodioxins	61-65	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
24521260-5	2014	After treatment of normal human epidermal keratinocytes with TCDD or PCBs, IL-6 and IL-8 production were increased.	Polychlorinated Biphenyls	69-73	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
24578240-1	2014	UNLABELLED: Under Medicare"s Coverage with Evidence Development policy, PET using (18)F-sodium fluoride (NaF PET) to identify osseous metastasis became a covered service if prospective registry data were collected.	Sodium Fluoride	88-103	C-X-C motif chemokine ligand 8	Homo sapiens	105-108
24504098-4	2014	Accordingly, aganirsen inhibited (P &lt; 0.001) in vitro the expression of interleukin-8 (IL-8), IL-12, IL-22, and tumor necrosis factor alpha (TNFalpha), four inflammatory mediators containing mRNA with AU-rich regions.	GS 101	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	75-88
24504098-4	2014	Accordingly, aganirsen inhibited (P &lt; 0.001) in vitro the expression of interleukin-8 (IL-8), IL-12, IL-22, and tumor necrosis factor alpha (TNFalpha), four inflammatory mediators containing mRNA with AU-rich regions.	GS 101	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
24399465-0	2014	Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis.	thymoquinone	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
24399465-6	2014	TQ treatments inhibited expression of NF-kappaB and suppressed IL-8 and its receptors.	thymoquinone	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
24399465-10	2014	TQ enhanced TRAIL-induced death of HepG2 cells, in part by up-regulating TRAIL death receptors, inhibiting NF-kappaB and IL-8 and stimulating apoptosis.	thymoquinone	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
24622069-5	2014	The influence of zerumbone on the angiogenic factors vascular endothelial growth factor and interleukin 8 was measured using the reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assays.	zerumbone	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	92-105
24486342-7	2014	Additionally, using a ROS scavenger, a siRNA that targets AMPK, and various pharmacological inhibitors, we identified the signaling cascade that leads to induction of IL-8 by CSE.	Reactive Oxygen Species	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
24486342-9	2014	Our findings suggest a novel role for glucosamine in alleviating the oxidative stress and lung inflammation induced by chronic CS exposure in vivo and in suppressing the CSE-induced IL-8 in vitro by inhibiting both the ROS-sensitive NADPH oxidase/AMPK/MAPK signaling pathway and the downstream transcriptional factors NF-kappaB and STAT3.	Glucosamine	38-49	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
24999851-5	2014	METHODS: Metal concentrations were analyzed in three hydrofluorosilicic acid (HFS) and four sodium fluoride (NaF) samples using inductively coupled plasma-atomic emission spectrometry.	Metals	9-14	C-X-C motif chemokine ligand 8	Homo sapiens	109-112
24999851-8	2014	Two NaF samples contained barium (13 3-18 0 ppm) instead.	Barium	26-32	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
24999851-9	2014	All HFS (212-415 ppm) and NaF (3312-3630 ppm) additives contained a surprising amount of aluminum.	Aluminum	89-97	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
24446657-5	2014	When activated by TSH, they produce IL-6, IL-8, and TNF-alpha.	Thyrotropin	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
25245457-2	2014	We show here that low extracellular magnesium stimulates the secretion of interleukin 8 and monocyte chemoattractant protein-1 in dermal microvascular endothelial cells.	Magnesium	36-45	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
24338998-6	2014	Additionally, phloretin inhibited monocyte secretion of MCP-1, IL-6 and IL-8 responsible for pro-inflammatory activity of thrombin inducing endothelial CD40.	Phloretin	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
24226202-9	2014	Furthermore, both gene knockdown and pharmacological inhibition studies showed that COX-2 mediates the TNF-alpha/IL-8 pathway by increasing the production of prostaglandin E2 (PGE2).	Dinoprostone	176-180	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
24721407-5	2014	RESULTS: The inhibition ratio of IL-8 in the EM group was significantly higher than that in the CSE group, but lower than that in the control group (P&lt;0.05).	Erythromycin	45-47	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
24676135-7	2014	Moreover, cellular cytokines IL-1beta, IL-6, IL-8 and TNF-alpha secretion as well as NF-kappaB activation in THP-1 cells were attenuated under high iron conditions.	Iron	148-152	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
24676135-8	2014	Low iron conditions in pure culture increased Salmonella invasion correlating with an increase in IL-8 release.	Iron	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
24664110-0	2014	The pneumococcal polysaccharide capsule and pneumolysin differentially affect CXCL8 and IL-6 release from cells of the upper and lower respiratory tract.	Polysaccharides	17-31	C-X-C motif chemokine ligand 8	Homo sapiens	78-83
24647471-0	2014	Sphingosine 1-phosphate induces neutrophil chemoattractant IL-8: repression by steroids.	sphingosine 1-phosphate	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
24500711-3	2014	Although dexamethasone-mediated activation of the glucocorticoid receptor (GR) potently repressed expression of IL1beta, IL8, and several other pro-inflammatory TNF targets, the expression of anti-inflammatory TNF targets such as TNFAIP3 (A20) and NFKBIA was selectively spared or augmented by dexamethasone treatment.	Dexamethasone	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	121-124
24528133-7	2014	Both ethanol and ethyl acetate extracts provided antiadhesion of H. pylori to AGS cells and down-regulation on the CagA, IL-8, COX-2, and iNOS expressions.	ethyl acetate	17-30	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
24528133-7	2014	Both ethanol and ethyl acetate extracts provided antiadhesion of H. pylori to AGS cells and down-regulation on the CagA, IL-8, COX-2, and iNOS expressions.	Ethanol	5-12	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
24647589-7	2014	Fetal brains were collected after 6 h. In human fetal membranes, silibinin significantly decreased LPS-stimulated expression of IL-6 and IL-8, COX-2, and prostaglandins PGE2 and PGF2alpha.	Silybin	65-74	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
24647471-0	2014	Sphingosine 1-phosphate induces neutrophil chemoattractant IL-8: repression by steroids.	Steroids	79-87	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
24647589-9	2014	Preterm fetal membranes with active infection treated with silibinin showed a decrease in IL-6, IL-8 and MMP-9 expression.	Silybin	59-68	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
24647471-6	2014	The corticosteroid dexamethasone significantly represses IL-8 mRNA expression and protein secretion in a concentration- and time-dependent manner.	Dexamethasone	19-32	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
24629040-8	2014	Treatments with PI3K inhibitors, Erk1/2 inhibitor, or Erlotinib significantly inhibited BTC-induced CXCL8 production and cell proliferation and movement.	Erlotinib Hydrochloride	54-63	C-X-C motif chemokine ligand 8	Homo sapiens	100-105
24499049-4	2014	Ni(II)-NTA-DG and the formed polyplexes induced an activation of iDCs, showing an increasing expression of costimulatory molecules CD86, CD80, and proinflammatory cytokines IL-6 and IL-8.	ni(ii)-nta-dg	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
24669186-8	2014	RESULTS: Genistein decreased the secretion of IL-1beta, IL-6, and IL-8 from TNF-alpha-stimulated MH7A cells in a dose-dependent manner.	Genistein	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
24669186-10	2014	The production of IL-1beta, IL-6, and IL-8 induced by TNF-alpha was decreased by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6, and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
24669186-10	2014	The production of IL-1beta, IL-6, and IL-8 induced by TNF-alpha was decreased by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6, and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
24629144-0	2014	Simvastatin down-regulates the production of interleukin-8 by neutrophil leukocytes from dyslipidemic patients.	Simvastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	45-58
24629144-2	2014	Aim of the study is to investigate the production of IL-8 by PMN leukocytes from dyslipidemic patients treated with simvastatin.	Simvastatin	116-127	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
24629144-6	2014	Moreover, the fMLP-induced IL-8 production in dyslipidemic untreated patients was higher than that of controls (p &lt; 0.05) and was reduced after simvastatin treatment (p &lt; 0.01).	Simvastatin	147-158	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
24629144-8	2014	CONCLUSIONS: Prolonged treatment with simvastatin is associated with a reduction of IL-8 production, suggesting the possibility of statin to modulate the pro-inflammatory response in PMNs of patients with moderately increased cardiovascular risk.	Simvastatin	38-49	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
23625984-10	2014	Dexamethasone downregulated pro-inflammatory mediator (IL-1beta, IL-6, TNFalpha, IFNgamma, MMP-9, TIMP-1, CCL3 and CXCL8) mRNAs but did not modify expression of vascular remodelling factors (platelet derived growth factor, MMP-2 and collagens I and III).	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	115-120
24598028-4	2014	RESULTS: Using RasG12V that recapitulates multiple stimulations induced by receptor tyrosine kinases, we found that RasG12V alone induced CXCL8 expression at the mRNA and protein levels, whereas down-regulation of p53 did not.	rasg12v	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	138-143
24717945-5	2014	The epidermal growth factor receptor tyrosine kinase inhibitor AG1478 inhibited the coculture-induced secretion of MUC5AC, PDGF-AB, VEGF, and IL-8.	RTKI cpd	63-69	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
24354854-0	2014	A novel phenylcyclohex-1-enecarbothioamide derivative inhibits CXCL8-mediated chemotaxis through selective regulation of CXCR2-mediated signalling.	phenylcyclohex-1-enecarbothioamide	8-42	C-X-C motif chemokine ligand 8	Homo sapiens	63-68
24310318-6	2014	Dapsone has been investigated predominantly by in vitro methods aiming to get more insights into the effect of dapsone to inflammatory effector cells, cytokines, and/or mediators, such as cellular toxic oxygen metabolism, myoloperoxidase-/halogenid system, adhesion molecules, chemotaxis, membrane-associated phospholipids, prostaglandins, leukotrienes, interleukin-8, tumor necrosis factor alpha, lymphocyte functions, and tumor growth.	Dapsone	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	354-396
24581246-8	2014	Acrolein was pro-inflammatory for the PNEC cultures (30 muM exposure for 4 h inducing a 2.0 fold increase in IL-8 release) and also increased IL-8 release after stimulation with PA LPS.	Acrolein	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
24581246-8	2014	Acrolein was pro-inflammatory for the PNEC cultures (30 muM exposure for 4 h inducing a 2.0 fold increase in IL-8 release) and also increased IL-8 release after stimulation with PA LPS.	Acrolein	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
24581246-8	2014	Acrolein was pro-inflammatory for the PNEC cultures (30 muM exposure for 4 h inducing a 2.0 fold increase in IL-8 release) and also increased IL-8 release after stimulation with PA LPS.	Protactinium	178-180	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
24581246-9	2014	In contrast, nicotine had anti-inflammatory properties (0.6 fold IL-8 release after 50 muM exposure to nicotine for 24 h), and acetylaldehyde was without effect.	Nicotine	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
24581246-9	2014	In contrast, nicotine had anti-inflammatory properties (0.6 fold IL-8 release after 50 muM exposure to nicotine for 24 h), and acetylaldehyde was without effect.	Nicotine	103-111	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
24579814-4	2014	The associated half-maximal effective concentration (EC50) values for Gro-alpha and IL-8 of 8 and 22 pM, respectively, are between two and three orders of magnitude below the so-far reported EC50 values of these chemokines for the induction of neutrophilic calcium release, integrin expression, degranulation, and receptor internalization.	Calcium	257-264	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
24579814-5	2014	Sch527123, a known inhibitor of CXCR2 (KD=49 pM) and with a lower potency/affinity also of CXCR1 (KD=3.9 nM), antagonized actin remodeling with half-maximal inhibitory concentration (IC50) values of 400 pM for the CXCR2-specific agonist Gro-alpha and of 36 nM for the CXCR1/2-promiscuous agonist IL-8.	2-hydroxy-N,N-dimethyl-3-(2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-enylamino)benzamide	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	296-300
24837313-7	2014	Adenosine modified myeloid cells express also higher levels of mRNA of proinflammatory cytokines and chemoattractants (IL-6, IL-8, IL-1 b).	Adenosine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
24508669-1	2014	BACKGROUND: 18F-Sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) are promising novel biomarkers of disease activity in aortic stenosis.	18f-sodium fluoride	12-31	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
24508669-7	2014	Baseline 18F-NaF uptake correlated closely with the change in calcium score (r=0.66; P&lt;0.01), and this improved further (r=0.75; P&lt;0.01) when 18F-NaF uptake overlying computed tomography-defined macrocalcification was excluded.	Calcium	62-69	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
24463979-0	2014	Interleukin 8 inhibition enhanced cholesterol efflux in acetylated low-density lipoprotein-stimulated THP-1 macrophages.	Cholesterol	34-45	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
24745085-5	2014	The addition of NaF as preservative improved the stability of opiates at all conditions studied, whereas the type of anticoagulant did not affect the stability of opiates.	Opiate Alkaloids	62-69	C-X-C motif chemokine ligand 8	Homo sapiens	16-19
24489105-4	2014	Serum levels of IFN-gamma, CCL4, and TNF-alpha were significantly increased, whereas CXCL8 significantly decreased from pretreatment (PRE) to early during treatment (EDT) serum samples.	edt	166-169	C-X-C motif chemokine ligand 8	Homo sapiens	85-90
24429901-4	2014	Of the controlled trials, the one including CRS patients just without polyps, showed a significant effect in sino-nasal outcome test, saccharine transit time, nasal endoscopy, and IL-8 levels in lavage fluid after 12 weeks of roxithromycin, whereas, in the other RCT with a mixed study group of CRS patients with and without polyps, 12 weeks of azithromycin showed no effect compared to placebo.	Roxithromycin	226-239	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
24700927-8	2014	Moreover, in an in vitro model of psoriasis (RHE), Calcitriol significantly inhibited relevant gene expression of chemokines (Interleukin-8, Regulated upon Activation Normal T-cell Expressed and Secreted [RANTES]) and psoriasin (S100A7).	Calcitriol	51-61	C-X-C motif chemokine ligand 8	Homo sapiens	126-139
24571702-4	2014	RESULTS: Specimens treated with the Sn-containing NaF dentifrice showed 6.5 mum of surface loss +- 1.2 (SEM), which was not significantly different (P &lt; 0.05, Fisher LSD) from that of a clinically proven, stabilised SnF2 positive control [Crest( ) Pro-Health, 1,100 ppm F as SnF2 : 3.0 mum of surface loss +- 1.1 (SEM)].	Tin	36-38	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
24641605-7	2014	On the other hand, IL-10 and IFN- alpha caused a significant decrease in type I collagen production, and IL-8 and GM-CSF caused a decrease in hyaluronan production compared with no cytokine-treated control.	Hyaluronic Acid	142-152	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
24463979-9	2014	Taken together, our results indicate that IL-8 exerts negative regulatory effects on cholesterol efflux from THP-1 cells and may thus represent a potential target for prevention and treatment of atherosclerosis.	Cholesterol	85-96	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
24489105-5	2014	The decrease in serum CXCL8 levels from PRE to EDT significantly correlated with decreases in markers of melanoma proliferation (Ki-67) and increases in cytotoxic tumor-infiltrating T cells in corresponding tumor biopsies.	edt	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	22-27
24489105-6	2014	In addition, a greater fold reduction in CXCL8 serum levels from PRE to EDT serum samples was associated with decreased overall survival.	edt	72-75	C-X-C motif chemokine ligand 8	Homo sapiens	41-46
24463979-3	2014	However, the effect of IL-8 on cholesterol efflux is still unclear.	Cholesterol	31-42	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
24463979-6	2014	Five and 10 microg/mL of human IL-8-neutralizing antibody enhanced cholesterol efflux from THP-1-derived macrophages by 1.2- and 1.4-fold, respectively.	Cholesterol	67-78	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
24501198-4	2014	In this study, we have shown that TSG-6 inhibits chemokine-stimulated transendothelial migration of neutrophils via a direct interaction (KD, ~ 25 nM) between TSG-6 and the glycosaminoglycan binding site of CXCL8, which antagonizes the association of CXCL8 with heparin.	Glycosaminoglycans	173-190	C-X-C motif chemokine ligand 8	Homo sapiens	207-212
24510965-9	2014	Overexpression of AGS3 in RBL-CXCR2 significantly inhibited CXCL8-induced Ca(2+) mobilization, phosphoinositide hydrolysis, and chemotaxis.	Phosphatidylinositols	95-111	C-X-C motif chemokine ligand 8	Homo sapiens	60-65
24501198-4	2014	In this study, we have shown that TSG-6 inhibits chemokine-stimulated transendothelial migration of neutrophils via a direct interaction (KD, ~ 25 nM) between TSG-6 and the glycosaminoglycan binding site of CXCL8, which antagonizes the association of CXCL8 with heparin.	Glycosaminoglycans	173-190	C-X-C motif chemokine ligand 8	Homo sapiens	251-256
24463979-8	2014	Ten micromoles of SB203580, an inhibitor of p38, almost completely suppressed the production of IL-8 from acetylated low-density lipoprotein-loaded THP-1 macrophages and accelerated cholesterol efflux.	SB 203580	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
24501198-5	2014	Furthermore, we found that TSG-6 impairs the binding of CXCL8 to cell surface glycosaminoglycans and the transport of CXCL8 across an endothelial cell monolayer.	Glycosaminoglycans	78-96	C-X-C motif chemokine ligand 8	Homo sapiens	56-61
24418375-3	2014	beta-glucan attenuated CD86 and CD80 expression and simultaneously reduced secretion of the inflammatory cytokines IL-2, IL-8, IL-12, TNF-alpha and IFN-gamma.	beta-Glucans	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
24320086-8	2014	Resveratrol suppressed TNF-alpha-induced IL-8 release from the ESC in a dose-dependent manner while sirtinol increased IL-8 release.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
24320086-8	2014	Resveratrol suppressed TNF-alpha-induced IL-8 release from the ESC in a dose-dependent manner while sirtinol increased IL-8 release.	sirtinol	100-108	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
24399488-6	2014	In addition, FME reduced the H2O2-induced expression of interleukin-8 at both the mRNA and protein levels in Caco-2 cells.	Hydrogen Peroxide	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
24257482-1	2014	AIM: (18)F-Sodium fluoride ((18)F-NaF) PET/computed tomography (CT) has improved spatial resolution in the cervical spine compared with single photon emission computed tomography/CT techniques using traditional tracers.	Sodium Fluoride	11-26	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
24418375-6	2014	In experiments with monocytes derived from healthy donors, beta-glucan inhibited IL-8, IL-12 and TNF-alpha production.	beta-Glucans	59-70	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
24494989-2	2014	The highly reversible electrochemical reactivity of CFx with Na at room temperature indicates that the decomposition of NaF could be driven by carbon formed during the first discharge.	Cefoxitin	52-55	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
24527095-8	2014	It was found that lipopolysaccharide and Pac significantly increase the secretion of IL-6 and IL-8 in the SKOV3 cell line.	Paclitaxel	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
24527095-9	2014	Similarly, Pac resulted in a significant upregulation of IL-6 and IL-8 in OVCAR3 cells, but not in A2780 and 3AO cells.	Paclitaxel	11-14	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
24587317-9	2014	In primary hPdLCs, both 25(OH)D3 and 1,25(OH)2D3 inhibited the production of IL-8 and MCP-1 but have no significant effect on the IL-6 production.	Calcifediol	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
24587317-9	2014	In primary hPdLCs, both 25(OH)D3 and 1,25(OH)2D3 inhibited the production of IL-8 and MCP-1 but have no significant effect on the IL-6 production.	Calcitriol	37-48	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
24494989-2	2014	The highly reversible electrochemical reactivity of CFx with Na at room temperature indicates that the decomposition of NaF could be driven by carbon formed during the first discharge.	Carbon	143-149	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
24459103-3	2014	To improve this situation, BODIPY-amidothiourea dyes with varying hydrogen-bond donating strengths were developed, the most H-acidic of which (1 c) could detect F(-) from an inorganic source (NaF) in 50 % aqueous solution (DMSO/water 1:1, v/v) with 0.01 ppm sensitivity through selective fluorescence quenching by a photoinduced electron-transfer (PET) process.	bodipy-amidothiourea	27-47	C-X-C motif chemokine ligand 8	Homo sapiens	192-195
24555532-8	2014	IL-8 release was blocked by EGFR neutralizing antibodies, an EGFR-selective tyrosine kinase inhibitor and by the metalloprotease inhibitor, GM6001, which blocks EGFR ligand shedding.	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	140-146	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
24693448-2	2014	The chemical mediator prostaglandin E2 (PGE2) and cytokines such as interleukin- (IL-)6 and IL-8 have been known to play important roles in inflammatory responses and tissue degradation.	Dinoprostone	22-38	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
24586752-4	2014	We found that the ceramide metabolite sphingosine-1-phosphate (S1P) stimulated the production of inflammatory mediators such as TNF-alpha and IL-8 from three-dimensionally cultured human primary keratinocytes (termed "3D keratinocytes"), which form a stratum corneum.	Ceramides	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
24586752-4	2014	We found that the ceramide metabolite sphingosine-1-phosphate (S1P) stimulated the production of inflammatory mediators such as TNF-alpha and IL-8 from three-dimensionally cultured human primary keratinocytes (termed "3D keratinocytes"), which form a stratum corneum.	sphingosine 1-phosphate	38-61	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
24586752-4	2014	We found that the ceramide metabolite sphingosine-1-phosphate (S1P) stimulated the production of inflammatory mediators such as TNF-alpha and IL-8 from three-dimensionally cultured human primary keratinocytes (termed "3D keratinocytes"), which form a stratum corneum.	sphingosine 1-phosphate	63-66	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
24586752-6	2014	In the presence of the detergent Triton X-100, which damages stratum corneum structure, PaCDase, but not heat-inactivated PaCDase or PaCDase-inactive mutant, induced the production of TNF-alpha, endothelin-1, and IL-8, indicating that this production was dependent on ceramidase activity.	Octoxynol	33-45	C-X-C motif chemokine ligand 8	Homo sapiens	213-217
24586752-7	2014	Among various ceramide metabolites, sphingosine and S1P enhanced the gene expression of TNF-alpha, endothelin-1, and IL-8.	Ceramides	14-22	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
24586752-7	2014	Among various ceramide metabolites, sphingosine and S1P enhanced the gene expression of TNF-alpha, endothelin-1, and IL-8.	Sphingosine	36-47	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
24586752-11	2014	The NF-kappaB inhibitor curcumin significantly inhibited PaCDase-induced expression of IL-8 and endothelin-1.	Curcumin	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
24586752-13	2014	Collectively, these findings suggest that (i) 3D keratinocytes produce S1P from sphingosine, which is produced through the hydrolysis of ceramide by PaCDase, (ii) S1P induces the production of TNF-alpha via S1P receptors, and (iii) released TNF-alpha stimulates the production of inflammatory mediators such as IL-8.	Sphingosine	80-91	C-X-C motif chemokine ligand 8	Homo sapiens	311-315
24459103-3	2014	To improve this situation, BODIPY-amidothiourea dyes with varying hydrogen-bond donating strengths were developed, the most H-acidic of which (1 c) could detect F(-) from an inorganic source (NaF) in 50 % aqueous solution (DMSO/water 1:1, v/v) with 0.01 ppm sensitivity through selective fluorescence quenching by a photoinduced electron-transfer (PET) process.	Dimethyl Sulfoxide	223-227	C-X-C motif chemokine ligand 8	Homo sapiens	192-195
24459103-3	2014	To improve this situation, BODIPY-amidothiourea dyes with varying hydrogen-bond donating strengths were developed, the most H-acidic of which (1 c) could detect F(-) from an inorganic source (NaF) in 50 % aqueous solution (DMSO/water 1:1, v/v) with 0.01 ppm sensitivity through selective fluorescence quenching by a photoinduced electron-transfer (PET) process.	Water	228-233	C-X-C motif chemokine ligand 8	Homo sapiens	192-195
24499192-0	2014	Pseudomonas pyocyanin stimulates IL-8 expression through MAPK and NF-kappaB pathways in differentiated U937 cells.	Pyocyanine	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
24499192-4	2014	RESULTS: It was found that PCN increased IL-8 release and mRNA expression in Phorbol 12-myristate 13-acetate (PMA) differentiated U937 cells in both a concentration- and time-dependent manner by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA).	Pyocyanine	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
24499192-4	2014	RESULTS: It was found that PCN increased IL-8 release and mRNA expression in Phorbol 12-myristate 13-acetate (PMA) differentiated U937 cells in both a concentration- and time-dependent manner by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA).	Tetradecanoylphorbol Acetate	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
24499192-8	2014	The results were further confirmed by the observation that p38, ERK1/2 and NF-kappaB inhibitors inhibited PCN-induced NF-kappaB activation and attenuated PCN-induced IL-8 expression in U937 cells as a function of their concentrations.	Pyocyanine	154-157	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
24499192-9	2014	Moreover, it was shown that PCN induced oxidative stress in U937 cells and N-acetyl cysteine, an antioxidant, was able to inhibit PCN-induced IL-8 protein expression.	Pyocyanine	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
24499192-9	2014	Moreover, it was shown that PCN induced oxidative stress in U937 cells and N-acetyl cysteine, an antioxidant, was able to inhibit PCN-induced IL-8 protein expression.	Acetylcysteine	75-92	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
24499192-9	2014	Moreover, it was shown that PCN induced oxidative stress in U937 cells and N-acetyl cysteine, an antioxidant, was able to inhibit PCN-induced IL-8 protein expression.	Pyocyanine	130-133	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
24499192-10	2014	CONCLUSIONS: It is concluded that PCN induces IL-8 secretion and mRNA expression in PMA-differentiated U937 cells in a concentration- and time- dependent manner.	Pyocyanine	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
24499192-11	2014	Furthermore, p38 and ERK MAPKs and NF-kappaBeta signaling pathways may be involved in the expression of IL-8 in PCN-incubated PMA-differentiated U937 cells.	Pyocyanine	112-115	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
24284797-9	2014	Interestingly, treatment of HCT116 cells with a small interference RNA specifically targeting SRSF3-PTC mRNA significantly attenuated arsenite-stimulated induction of c-JUN protein, its binding activity to the AP-1 binding site (-126 to 120 bp) in the interleukin (IL)-8 gene promoter, and AP-1 promoter activity, resulting in significant reduction of arsenite-stimulated IL-8 production.	arsenite	134-142	C-X-C motif chemokine ligand 8	Homo sapiens	252-270
24211732-5	2014	Necrotic damage was most likely due to osmotic stress, and our results suggest that magnesium ion build-up is also involved in the interleukin 8 release.	Magnesium	84-93	C-X-C motif chemokine ligand 8	Homo sapiens	131-144
24284797-9	2014	Interestingly, treatment of HCT116 cells with a small interference RNA specifically targeting SRSF3-PTC mRNA significantly attenuated arsenite-stimulated induction of c-JUN protein, its binding activity to the AP-1 binding site (-126 to 120 bp) in the interleukin (IL)-8 gene promoter, and AP-1 promoter activity, resulting in significant reduction of arsenite-stimulated IL-8 production.	arsenite	134-142	C-X-C motif chemokine ligand 8	Homo sapiens	372-376
23931157-4	2014	The co-incubation of the cells with Ind, at a nutritionally relevant concentration (5-25 muM), and IL-1beta prevented the release of the pro-inflammatory cytokines IL-6 and IL-8, PGE2 and NO, the formation of ROS and the loss of thiols in a dose-dependent manner.	indicaxanthin	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
24136171-5	2014	The selective cell-permeable inhibitor of PKC-beta and the broad PKC inhibitor GF109203X completely prevented chemical allergen- or lipopolysaccharide (LPS)-induced CD86 expression and significantly modulated IL-8 release (50 % reduction).	bisindolylmaleimide I	79-88	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
23981542-10	2014	Resveratrol was superior to dexamethasone in reducing CCL-2, IL-6 and IL-8 in LTA-exposed HASMCs of patients with COPD.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
23981542-10	2014	Resveratrol was superior to dexamethasone in reducing CCL-2, IL-6 and IL-8 in LTA-exposed HASMCs of patients with COPD.	hasmcs	90-96	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
24030221-7	2014	Furthermore, passive smoke exposure reduced the inhibitory effects of dexamethasone on tumor necrosis factor-alpha-induced CXCL8 release in AMs.	Dexamethasone	70-83	C-X-C motif chemokine ligand 8	Homo sapiens	123-128
24292270-6	2014	Twenty nanometers CPS particles stimulated IL-8 secretion in human monocytes and induced oxidative burst in monocytes.	cps	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
24292270-7	2014	Five hundred nanometers and 1,000 nm CPS particles stimulated IL-6 and IL-8 secretion in monocytes and macrophages, chemotaxis towards a chemotactic stimulus of monocytes and phagocytosis of bacteria by macrophages and provoked an oxidative burst of granulocytes.	cps	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
24372819-6	2014	Treatment of HaCaT cells with histamine and TNFalpha enhanced the mRNA expression of interleukin (IL)-8.	Histamine	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	85-103
24502806-12	2014	In vitro assays revealed that TMP inhibited NF-kappaB translocation and its downstream production of inflammatory factors, such as TNF-alpha, IL-6 and IL-8, and that ROS production that was induced by LPS in Caco-2 cells.	tetramethylpyrazine	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
24338213-4	2014	We find that these ions may be generated efficiently by two distinct methods: (1) negative ion ESI of a methanolic solution containing the fatty acid and sodium fluoride forming an [M - H  +  NaF](-) ion.	Fatty Acids	139-149	C-X-C motif chemokine ligand 8	Homo sapiens	192-195
24318613-0	2014	Divergent determinants of 18F-NaF uptake and visible calcium deposition in large arteries: relationship with Framingham risk score.	Fluorine-18	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
24296811-9	2014	Pretreatment with an antioxidant suppressed TNFalpha-induced IL-8 expression, confirming the role of ROS in TNFalpha signaling.	Reactive Oxygen Species	101-104	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
24338213-4	2014	We find that these ions may be generated efficiently by two distinct methods: (1) negative ion ESI of a methanolic solution containing the fatty acid and sodium fluoride forming an [M - H  +  NaF](-) ion.	Sodium Fluoride	154-169	C-X-C motif chemokine ligand 8	Homo sapiens	192-195
24377455-8	2014	Compared with placebo, the consumption of bayberry juice significantly decreased the plasma levels of protein carbonyl groups (P = 0.038), tumor necrosis factor-alpha (P &lt; 0.001), and interleukin-8 (P = 0.022).	bayberry juice	42-56	C-X-C motif chemokine ligand 8	Homo sapiens	187-200
24370750-2	2014	The observed linear-mode trajectory pattern of neutrophils toward N-formyl-methionyl-leucyl-phenylalanine (fMLP) or Interleukin (IL)-8/CXCL8 was distinguished from random migration patterns toward leukotriene (LT) B4 or platelet activating factor (PAF).	Leukotrienes	197-208	C-X-C motif chemokine ligand 8	Homo sapiens	135-140
24268047-9	2014	EGF prompted the cell movement in both HepG2 and HCCLM3 and regulated the production of CXCL5 and CXCL8 from HCC, which were inhibited by EGFR inhibitor, Erk inhibitor (U0126), or PI3K inhibitors (BEZ-235 and SHBM1009).	U 0126	169-174	C-X-C motif chemokine ligand 8	Homo sapiens	98-103
24316968-7	2014	Carnosol not only inhibited TNF-alpha-induced protein expression of intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and E-selectin in HUVECs, but also suppressed interleukin (IL)-8 and monocyte chemoattractant protein (MCP)-1 expression.	carnosol	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	197-215
24394883-12	2014	In response to exposure to lactobacilli EPSs HT29-19A cells produce significantly increased levels of the proinflammatory cytokine IL-8.	epss	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
24269928-6	2014	Carbachol concentration-dependently enhanced the production of IL-1beta-induced IL-6 and IL-8, which was blocked by the simultaneous addition of tiotropium.	Carbachol	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
24269928-6	2014	Carbachol concentration-dependently enhanced the production of IL-1beta-induced IL-6 and IL-8, which was blocked by the simultaneous addition of tiotropium.	Tiotropium Bromide	145-155	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
24269928-7	2014	The combination of olodaterol plus tiotropium further reduced IL-6 and IL-8 release.	olodaterol	19-29	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
24731418-1	2014	OBJECTIVE: To compare the ability of the polysaccharide from various Porphyromonas gingivalis (Pg) type and clinical strains in inducing THP-1 cells to produce cytokines interleukin(IL)-1beta, IL-8, and tumor necrosis factor(TNF)-alpha, in order to analyze the immunogenicity of Pg polysaccharide components and the virulence-associated factors of this periodontal pathogen.	Polysaccharides	41-55	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
24731418-8	2014	CONCLUSIONS: Polysaccharide extracted from Pg could induced the THP-1 cells to secrete the cytokines of IL-1beta, IL-8 and TNF-alpha.	Polysaccharides	13-27	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
24396446-9	2014	The following parameters were found to be reduced following the use of methylprednisolone: Interleukin (IL)-6 immediately following surgery and on postoperative days (PODs) 1 and 3; IL-8 immediately following surgery; and PaO2/FiO2 on POD 3.	Methylprednisolone	71-89	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
24337575-5	2014	The responsible mechanism involves an increased nuclear accumulation of IkappaB kinase beta (IKKbeta) and an increased recruitment of the nuclear IKKbeta, p65-phosphorylated at Ser-536, and the transcription factor early growth response-1 (EGR-1) to the endogenous IL-8 promoter.	Serine	177-180	C-X-C motif chemokine ligand 8	Homo sapiens	265-269
24344116-8	2014	Modulation of genes related with invasion, metastasis and chemoresistance (ICAM-1, CXCL1, TNFAIP3, IL8) were confirmed in additional doxorubicin-treated cell lines and fresh primary human breast tumors.	Doxorubicin	133-144	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
24551277-7	2014	HeLa and SiHa cells cultured in 1% oxygen showed the increased viability and apoptosis, and the former effect could be partly reversed by anti-human IL-8 neutralizing antibody.	Oxygen	35-41	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
24485462-5	2014	Specifically, the nitrogen mustard cyclophosphamide induces an acute secretory activating phenotype (ASAP), releasing CCL4, IL8, VEGF, and TNFalpha from treated tumor cells.	Nitrogen	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	124-127
24485462-5	2014	Specifically, the nitrogen mustard cyclophosphamide induces an acute secretory activating phenotype (ASAP), releasing CCL4, IL8, VEGF, and TNFalpha from treated tumor cells.	Cyclophosphamide	35-51	C-X-C motif chemokine ligand 8	Homo sapiens	124-127
24475177-6	2014	Vitamin D supplementation had no significant effects on RV replication, but potentiated secretion of CXCL8 and CXCL10 from infected or uninfected cells.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	101-106
24117378-4	2014	We demonstrated that girolline inhibits signaling through both MyD88-dependent and -independent TLRs (i.e., TLR2, 3, 4, 5, and 7) and reduces cytokine (IL-6 and IL-8) production in human peripheral blood mononuclear cells and macrophages.	girolline	21-30	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
24231947-10	2014	CONCLUSION: IL8-level changes during pazopanib allowed for a prognostic improvement and were associated with response probability.	pazopanib	37-46	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
24296301-10	2014	Solvent (DMSO) controls exhibited statistically significantly decreased responses compared with non-treated controls for IL-6 release and IL-8 mRNA expression, but these responses were not consistent across experiments and times.	Dimethyl Sulfoxide	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
24401117-11	2014	Expression of the IL-8 data with respect to either of these metrics eliminated the differential response between the RTI amosite sample and the other samples that was observed when HAEC were exposed on an equal mass basis.	Asbestos, Amosite	121-128	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
24129312-2	2014	In the current study, we generated and characterized a 2"-fluoro-pyrimidine modified RNA aptamer (8A-35) against human IL-8.	2"-fluoro-pyrimidine	55-75	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
25257149-4	2014	IL-8 production by HaCaT cells is stimulated by egg-oil whilst in phythemagglutin in-activated PBMLs production of the interleukins IL-2, IL-6, IL-10 and IFN-gamma and TFN-alpha is reduced.	egg-oil	48-55	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
24128422-2	2014	We investigated the effect of lipopolysacharide (LPS) and progesterone (P4) upon expression of TLR-4/MyD88, TNFalpha, IL-6, IL-8, IL-10, and HBD2 on the human amniotic epithelium.	Progesterone	58-70	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
24128422-6	2014	LPS increased the concentrations of TNFalpha, IL-6, IL-8, IL-10, and HBD2 by factors of 30-, eight, three, three, and fivefold, respectively.	lps	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
24164087-7	2014	Budesonide also reduced the concentrations of tumour necrosis factor-alpha, interleukin-1beta, interleukin-6 and interleukin-8 in bronchoalveolar lavage fluid, but increased interleukin-10 30 min after re-expansion (p &lt; 0.05 for all measures).	Budesonide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	113-126
25169512-0	2014	Influence of propofol, isoflurane and enflurance on levels of serum interleukin-8 and interleukin-10 in cancer patients.	Propofol	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	68-81
25169512-1	2014	OBJECTIVE: To observe the influence of propofol, isoflurane and enflurance on interleukin-8 (IL-8) and IL-10 levels in cancer patients.	Propofol	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	78-91
25169512-12	2014	CONCLUSIONS: Propofol, which is better in inhibiting serum IL-8 secretion and improving IL-10 secretion than isoflurane and enflurance, can be regarded as a preferable anesthetic agent in inhibiting traumatic inflammatory responses.	Propofol	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
25147797-5	2014	Increases of IL-6 and IL-8 release (by ELISA) were detected in A549 cells exposed to MWCNTs-COOH from 10 mug/mL while IL-8 increased in BEAS-2B cells exposed to pristine MWCNTs at 20 and 40 mug/mL.	Carbonic Acid	92-96	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
25162011-7	2014	RA produced a significant reduction in UVB-induced expression of IL-6, IL-8, MCP-1, and TNF-alpha when applied at the same time as irradiation.	rosmarinic acid	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
25140317-9	2014	Furthermore, we found that doxorubicin resistance of TNBC was mediated by IL-8 presented in the MSC-secreted CM.	Doxorubicin	27-38	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
25162011-3	2014	We assessed the ability of EA and RA to modulate IL-1beta, IL-6, IL-8, IL-10, MCP-1, and TNF-alpha gene expression in HaCaT cells after UVB irradiation.	Ellagic Acid	27-29	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
25140722-0	2014	Insoluble NaF in Duraphat  may prolong fluoride reactivity of varnish retained on dental surfaces.	sodium fluoride topical preparation	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	10-13
25140722-8	2014	In conclusion, a longer varnish retention time than the usually recommended could improve the anticaries effect of Duraphat  varnish, allowing that NaF particles, initially insoluble in the varnish matrix, prolong the reactivity with enamel.	sodium fluoride topical preparation	115-123	C-X-C motif chemokine ligand 8	Homo sapiens	148-151
24789288-1	2014	This study compared in situ the application of 4% titanium tetrafluoride (TiF4) solution and 2% sodium fluoride (NaF) gel on artificial white-spot lesions in human enamel.	Sodium Fluoride	96-111	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
25430458-9	2014	A positive correlation was found between levels of serum SO2 and intracellular NF-kappaB/IL-8, and the correlation coefficients were 0.671 and 0.798 (P &lt; 0.05), respectively.	Sulfur Dioxide	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
24220935-6	2014	In multivariate analysis, baseline sVEGFR-3 and IL-8 remained independent predictors of OS in the sunitinib arm, while no independent predictors of outcome remained in the IFN-alpha arm.	Sunitinib	98-107	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
24557443-5	2014	The average weight percentage of fluoride for all F-varnishes containing NaF ranged from 2.03 to 2.24% F, which is within 90% of the declared label concentration of 2.26% F. Analysis of the difluorosilane-containing product required an additional hydrolysis step.	Fluorides	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	73-76
23787997-5	2014	MTX stimulated the production of CXCL8 by human cancer cells in vitro and that of Cxcl2 by murine tumors in vivo.	Mitoxantrone	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	33-38
23787997-6	2014	The knockdown of CXCL8/Cxcl2 receptors (CXCR1/Cxcr1 and Cxcr2) reduced MTX-induced CRT exposure in both human and murine cancer cells, as well as the capacity of the latter-on exposure to MTX-to elicit an anticancer immune response in vivo.	Mitoxantrone	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	17-22
23787997-6	2014	The knockdown of CXCL8/Cxcl2 receptors (CXCR1/Cxcr1 and Cxcr2) reduced MTX-induced CRT exposure in both human and murine cancer cells, as well as the capacity of the latter-on exposure to MTX-to elicit an anticancer immune response in vivo.	Mitoxantrone	188-191	C-X-C motif chemokine ligand 8	Homo sapiens	17-22
25382335-10	2014	The mRNA expressions of IL-1alpha, IL-6, IL-8, and TNF-a in different concentrations of SDBS at different time were comparable with that of controls.	dodecylbenzenesulfonic acid	88-92	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
24877120-5	2014	SLURP-1 diminished the TLR9-dependent secretion of IL-8 by CCL-241, and IFN gamma-induced upregulation of ICAM-1 in both IEC types.	Cefaclor	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
24877120-6	2014	rSLURP-2 inhibited IL-1 beta-induced secretion of IL-6 and TLR4- and TLR9-dependent induction of CXCL10 and IL-8, respectively, in CCL-241.	Cefaclor	131-134	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
25059554-0	2014	Nicotine induces the production of IL-1beta and IL-8 via the alpha7 nAChR/NF-kappaB pathway in human periodontal ligament cells: an in vitro study.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
25059554-6	2014	RESULTS: Compared with the control group, nicotine could significantly induce production of IL-1beta and IL-8 in human PDL cells and cause the similar effects on the expression of the NF-kappaB p65 subunit and NF-kappaB activity.	Nicotine	42-50	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
25059554-7	2014	CONCLUSION: This study demonstrates that nicotine could induce production of IL-1beta and IL-8 via the alpha7 nAChR/NF-kappaB pathway in human PDL cells, providing data for a better understanding of the relationships among smoking, nicotine, and periodontitis.	Nicotine	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
25059554-7	2014	CONCLUSION: This study demonstrates that nicotine could induce production of IL-1beta and IL-8 via the alpha7 nAChR/NF-kappaB pathway in human PDL cells, providing data for a better understanding of the relationships among smoking, nicotine, and periodontitis.	Nicotine	232-240	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
25430458-10	2014	According to the results found in human THP-1 cells, levels of NF-kappaB and IL-8 in LPS group were significantly increased compared with those of the control group (P &lt; 0.05); when compared with those in LPS group, levels of NF-kappaB in LPS+HDX group further increased significantly (P &lt; 0.05); however, the NF-kappaB levels of LPS+SO2 group decreased significantly (P &lt; 0.05).	Sulfur Dioxide	340-343	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
24096876-10	2014	mRNA and protein expression of TNF-alpha, IL-8, and IL-6 in cells treated with DCA alone were up-regulated, and intra-cellular ROS and p-NF-kappaB p65 protein levels were also increased.	Deoxycholic Acid	79-82	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
23844733-5	2014	CXC chemokines (such as interleukin-8) are bound to glycosaminoglycans on the endothelial surface and activate captured neutrophils, inducing expression of integrins.	Glycosaminoglycans	52-70	C-X-C motif chemokine ligand 8	Homo sapiens	24-37
23959576-6	2014	Furthermore, interleukin 8, osteopontin, hepatocyte growth factor, and tissue inhibitors of metalloproteinases-1 in peripheral blood enable assessment of responsiveness to pazopanib treatment.	pazopanib	172-181	C-X-C motif chemokine ligand 8	Homo sapiens	13-26
24701591-3	2014	Arterial calcification has been also determined by CT, by (18)F-FDG PET and also in the last few years by (18)F-sodium fluoride (NaF) PET.	Sodium Fluoride	112-127	C-X-C motif chemokine ligand 8	Homo sapiens	129-132
24161763-7	2014	Exogenous IL-8 increased the SP fraction and expression of multidrug resistance-1, decreasing the drug sensitivity.	sp	29-31	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
24488902-10	2014	Tiopronin can reduce the levels of ET, leptin, IL-6 and IL-8 for treatment of NAFLD.	Tiopronin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
24309288-4	2014	Sodium iodate-mediated RPE cell death was associated with increased levels of reactive oxygen species (ROS) and IL-8.	sodium iodate	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
24309288-5	2014	Resveratrol, a natural occurring polyphenol compound, was found to strongly protect RPE cells from sodium iodate with inhibition of production of ROS and IL-8.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
24309288-10	2014	Moreover, PPAR agonists reversed sodium iodate-induced production of IL-8.	sodium iodate	33-46	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
24056816-5	2014	In vitro, busulfan elicits pro-inflammatory activation (increased NF-KappaB activity and interleukin-8 expression) in human hepatoma cells.	Busulfan	10-18	C-X-C motif chemokine ligand 8	Homo sapiens	89-102
24701591-5	2014	Fluorine-18-NaF uptake in the heart and aorta increased significantly with advancing age.	Fluorine-18	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
24739825-7	2014	Furthermore, after pretreatment of Ec109 cells with the specific p38 MAPK inhibitor SB203580, Ec109 cells proliferation and IL-8 secretion were inhibited.	SB 203580	84-92	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
24297055-9	2014	RESULTS: Muramyl dipeptide-induced increases in NOD2, interleukin-8, and CXCL3 expression were inversely associated with miRNA expression.	Dipeptides	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
24126532-5	2014	We found that HbR induced interleukin-8 (IL-8) production in the human gingival epithelial cell line Ca9-22.	Hydrobromic Acid	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	26-39
24126532-5	2014	We found that HbR induced interleukin-8 (IL-8) production in the human gingival epithelial cell line Ca9-22.	Hydrobromic Acid	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
24126532-7	2014	Inhibitors of p38 MAPK (SB203580) and Erk1/2 (PD98059) blocked HbR-induced IL-8 production.	SB 203580	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
24126532-7	2014	Inhibitors of p38 MAPK (SB203580) and Erk1/2 (PD98059) blocked HbR-induced IL-8 production.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	46-53	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
24126532-7	2014	Inhibitors of p38 MAPK (SB203580) and Erk1/2 (PD98059) blocked HbR-induced IL-8 production.	Hydrobromic Acid	63-66	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
24126532-8	2014	Additionally, HbR stimulated the translocation of NF-kappaB-p65 to the nucleus, consistent with enhancement of IL-8 expression by activation of the NF-kappaB pathway.	Hydrobromic Acid	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
24126532-9	2014	In addition, small interfering RNA (siRNA) targeting activating transcription factor 2 (ATF-2) or cyclic AMP-response element-binding protein (CREB) inhibited HbR-induced IL-8 production.	Hydrobromic Acid	159-162	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
24297055-10	2014	Overexpression of miR-192, miR-495, miR-512, and miR-671 suppressed NOD2 expression, muramyl dipeptide-mediated NF-kappaB activation, and messenger RNA expressions of interleukin-8 and CXCL3 in HCT116 cells.	Dipeptides	93-102	C-X-C motif chemokine ligand 8	Homo sapiens	167-180
24346217-7	2014	ELISA confirmed the protective effect of insulin and SP600125 on Abeta-induced expression of interleukin (IL)-8 and Growth related oncogene-alpha (Gro-alpha).	pyrazolanthrone	53-61	C-X-C motif chemokine ligand 8	Homo sapiens	93-111
24126532-11	2014	Combined pretreatment with an inhibitor of NF-kappaB (BAY11-7082) and SB203580 was more efficient in inhibiting the ability of HbR to induce IL-8 production than pretreatment with either BAY11-7082 or SB203580 alone.	3-(4-methylphenylsulfonyl)-2-propenenitrile	54-64	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
24126532-11	2014	Combined pretreatment with an inhibitor of NF-kappaB (BAY11-7082) and SB203580 was more efficient in inhibiting the ability of HbR to induce IL-8 production than pretreatment with either BAY11-7082 or SB203580 alone.	SB 203580	70-78	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
24126532-11	2014	Combined pretreatment with an inhibitor of NF-kappaB (BAY11-7082) and SB203580 was more efficient in inhibiting the ability of HbR to induce IL-8 production than pretreatment with either BAY11-7082 or SB203580 alone.	Hydrobromic Acid	127-130	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
23826669-0	2014	Palmitate induces interleukin-8 expression in human aortic vascular smooth muscle cells via Toll-like receptor 4/nuclear factor-kappaB pathway (TLR4/NF-kappaB-8).	Palmitates	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
24366255-7	2014	IL-8(r=0.35-0.47) and TNF (r=0.42-0.53) expression levels exhibited strong correlations with the leukotriene genes.	Leukotrienes	97-108	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
24366255-10	2014	CONCLUSIONS: Leukotrienes and inflammatory genes, in particular, LTA4H and IL-8, exhibit close association in subjects with cardiovascular disease.	Leukotrienes	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
23826669-4	2014	The aim of this study was to investigate the regulation of IL-8 expression by free fatty acids and determine the underlying mechanisms in HVSMCs.	Fatty Acids, Nonesterified	78-94	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
23826669-6	2014	RESULTS: Palmitate induced IL-8 mRNA expression and secretion in a dose-dependent manner.	Palmitates	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
23826669-8	2014	Parthenolide pretreatment also abolished IL-8 mRNA and protein induction by palmitate.	parthenolide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
23826669-8	2014	Parthenolide pretreatment also abolished IL-8 mRNA and protein induction by palmitate.	Palmitates	76-85	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
23826669-10	2014	Inhibition of protein kinase C (PKC) activation with calphostin C and chelerythrine partially suppressed palmitate-stimulated IL-8 expression, but it had no effect on palmitate-induced NF-kappaB activation.	calphostin C	53-65	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
23826669-10	2014	Inhibition of protein kinase C (PKC) activation with calphostin C and chelerythrine partially suppressed palmitate-stimulated IL-8 expression, but it had no effect on palmitate-induced NF-kappaB activation.	chelerythrine	70-83	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
23826669-10	2014	Inhibition of protein kinase C (PKC) activation with calphostin C and chelerythrine partially suppressed palmitate-stimulated IL-8 expression, but it had no effect on palmitate-induced NF-kappaB activation.	Palmitates	105-114	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
23826669-11	2014	Finally, knockdown of TLR4 markedly abolished palmitate-induced NF-kappaB activation and IL-8 expression.	Palmitates	46-55	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
23826669-12	2014	CONCLUSIONS: Palmitate induces IL-8 gene expression in HVSMCs through the TLR4/NF-kappaB pathway.	Palmitates	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
24555677-7	2014	Exposure of THP-1 cells to both sizes of ZnO stimulated and increased release of proinflammatory cytokines interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and IL-6, as well as chemokine IL-8, and upregulated the expression of monocyte chemoattractant protein-1 and cyclooxygenase-2 genes.	Zinc Oxide	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
24277696-6	2014	The thrombin-induced increases in IL-8/CXCL8 release and IL-8/CXCL8-luciferase were also inhibited by MEKK1 siRNA, PD98059 (an MEK inhibitor), U0126 (an ERK inhibitor), and RSK1 siRNA.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	115-122	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
24277696-6	2014	The thrombin-induced increases in IL-8/CXCL8 release and IL-8/CXCL8-luciferase were also inhibited by MEKK1 siRNA, PD98059 (an MEK inhibitor), U0126 (an ERK inhibitor), and RSK1 siRNA.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	115-122	C-X-C motif chemokine ligand 8	Homo sapiens	39-44
24277696-6	2014	The thrombin-induced increases in IL-8/CXCL8 release and IL-8/CXCL8-luciferase were also inhibited by MEKK1 siRNA, PD98059 (an MEK inhibitor), U0126 (an ERK inhibitor), and RSK1 siRNA.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	115-122	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
24277696-6	2014	The thrombin-induced increases in IL-8/CXCL8 release and IL-8/CXCL8-luciferase were also inhibited by MEKK1 siRNA, PD98059 (an MEK inhibitor), U0126 (an ERK inhibitor), and RSK1 siRNA.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	115-122	C-X-C motif chemokine ligand 8	Homo sapiens	62-67
24277696-6	2014	The thrombin-induced increases in IL-8/CXCL8 release and IL-8/CXCL8-luciferase were also inhibited by MEKK1 siRNA, PD98059 (an MEK inhibitor), U0126 (an ERK inhibitor), and RSK1 siRNA.	U 0126	143-148	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
24277696-6	2014	The thrombin-induced increases in IL-8/CXCL8 release and IL-8/CXCL8-luciferase were also inhibited by MEKK1 siRNA, PD98059 (an MEK inhibitor), U0126 (an ERK inhibitor), and RSK1 siRNA.	U 0126	143-148	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
24277696-6	2014	The thrombin-induced increases in IL-8/CXCL8 release and IL-8/CXCL8-luciferase were also inhibited by MEKK1 siRNA, PD98059 (an MEK inhibitor), U0126 (an ERK inhibitor), and RSK1 siRNA.	U 0126	143-148	C-X-C motif chemokine ligand 8	Homo sapiens	62-67
24163441-8	2014	Although methacholine and U46619 induced interleukin-8 (IL-8) release and this was inhibited by RGS2 overexpression, the repression of U46619-induced IL-8 release by salmeterol plus dexamethasone was unaffected by RGS2 knockdown.	Methacholine Chloride	9-21	C-X-C motif chemokine ligand 8	Homo sapiens	41-54
24163441-8	2014	Although methacholine and U46619 induced interleukin-8 (IL-8) release and this was inhibited by RGS2 overexpression, the repression of U46619-induced IL-8 release by salmeterol plus dexamethasone was unaffected by RGS2 knockdown.	Methacholine Chloride	9-21	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
24163441-8	2014	Although methacholine and U46619 induced interleukin-8 (IL-8) release and this was inhibited by RGS2 overexpression, the repression of U46619-induced IL-8 release by salmeterol plus dexamethasone was unaffected by RGS2 knockdown.	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid	26-32	C-X-C motif chemokine ligand 8	Homo sapiens	41-54
24163441-8	2014	Although methacholine and U46619 induced interleukin-8 (IL-8) release and this was inhibited by RGS2 overexpression, the repression of U46619-induced IL-8 release by salmeterol plus dexamethasone was unaffected by RGS2 knockdown.	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid	26-32	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
24163441-8	2014	Although methacholine and U46619 induced interleukin-8 (IL-8) release and this was inhibited by RGS2 overexpression, the repression of U46619-induced IL-8 release by salmeterol plus dexamethasone was unaffected by RGS2 knockdown.	Salmeterol Xinafoate	166-176	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
24163441-8	2014	Although methacholine and U46619 induced interleukin-8 (IL-8) release and this was inhibited by RGS2 overexpression, the repression of U46619-induced IL-8 release by salmeterol plus dexamethasone was unaffected by RGS2 knockdown.	Dexamethasone	182-195	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
25119735-0	2014	Regulation of IL-8 promoter activity by verrucarin A in human monocytic THP-1 cells.	muconomycin A	40-52	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
25119735-8	2014	Mutation of the CCAAT/enhancer-binding protein (CEBP) beta binding site of the IL-8 promoter affected only DON-, but not VA- and TNFalpha-induced luciferase expression.	deoxynivalenol	107-110	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
25268553-3	2014	This study focused on examining the adverse effects of inorganic fluoride (NaF) on human lymphocyte cells in vitro.	inorganic fluoride	55-73	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
26054180-13	2014	CONCLUSION: The Enamelon products (970 ppm and 1150 ppm F- ion, SnF2 OTC dentifrices) delivering ACP were statistically significantly more effective in reducing enamel solubility than two Rx strength 5000 ppm F- ion NaF toothpastes containing TCP and the Rx 900 ppm F- ion NaF paste containing CPP-ACP.	amorphous calcium phosphate	97-100	C-X-C motif chemokine ligand 8	Homo sapiens	216-219
26054180-13	2014	CONCLUSION: The Enamelon products (970 ppm and 1150 ppm F- ion, SnF2 OTC dentifrices) delivering ACP were statistically significantly more effective in reducing enamel solubility than two Rx strength 5000 ppm F- ion NaF toothpastes containing TCP and the Rx 900 ppm F- ion NaF paste containing CPP-ACP.	amorphous calcium phosphate	97-100	C-X-C motif chemokine ligand 8	Homo sapiens	273-276
24336915-0	2014	Reduction of interleukin 8 and platelet-derived growth factor levels by topical ketorolac, 0.45%, in patients with diabetic retinopathy.	Ketorolac	80-89	C-X-C motif chemokine ligand 8	Homo sapiens	13-26
24336915-8	2014	Levels of IL-8 (41% reduction; P = .002) and PDGF-AA (21% reduction; P = .009) were significantly lower in the vitreous of patients treated with ketorolac.	Ketorolac	145-154	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
24336915-9	2014	CONCLUSIONS AND RELEVANCE: Topical ketorolac tromethamine, 0.45%, significantly lowered aqueous IL-8 levels and vitreous IL-8 and PDGF-AA levels in this series of eyes, suggesting that it may cause meaningful inhibition of inflammatory cytokines implicated in the pathogenesis of DR. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01609881.	Ketorolac Tromethamine	35-57	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
24336915-9	2014	CONCLUSIONS AND RELEVANCE: Topical ketorolac tromethamine, 0.45%, significantly lowered aqueous IL-8 levels and vitreous IL-8 and PDGF-AA levels in this series of eyes, suggesting that it may cause meaningful inhibition of inflammatory cytokines implicated in the pathogenesis of DR. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01609881.	Ketorolac Tromethamine	35-57	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
25165413-7	2014	Our findings suggest a novel role for paeonol in alleviating the oxidative stress and lung inflammation induced by chronic CS exposure in vivo and in suppressing CSE-induced IL-8 in vitro via its antioxidant function and an inhibition of the MAPKs/NF-kappaB signaling.	paeonol	38-45	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
24864134-4	2014	Furthermore, 2-Cl-IB-MECA significantly decreased TNF-alpha-stimulated IL-8 and IL-1beta mRNA expression and secretion, compared to the TNF-alpha-only treated group.	2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
25484047-9	2014	The IL-8 binding site of CXCR2 was identified by screening peptide libraries with the IL-8 ligand, and then reconstructed as soluble synthetic peptides.	Peptides	143-151	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
25484064-4	2014	The hybridoma-derived antibody fully inhibited IL-8 and Gro-alpha responses in calcium flux and beta-arrestin recruitment assays.	Calcium	79-86	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
24908306-4	2014	Binding of the IL-8 ligand to the CXCR2 receptor results in an intracellular signaling pathway mediated by GTP binding proteins coupled to the receptor itself.	Guanosine Triphosphate	107-110	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
25530684-5	2014	EXPERIMENTAL APPROACH: Time course and dose-dependent release of interleukin- (IL-) 6 and IL-8 from A549 were measured after pretreatment of A549 with EtP (2.5-10 mM), sodium pyruvate (NaP, 10 mM), or EtOH (85-170 mM), and subsequent lipopolysaccharide or IL-1beta stimulation.	ethyl pyruvate	151-154	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
25530684-7	2014	KEY RESULTS: Treating A549 with EtOH or EtP reduced substantially the cytokine-induced release of IL-8 and IL-6.	Ethanol	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
25530684-7	2014	KEY RESULTS: Treating A549 with EtOH or EtP reduced substantially the cytokine-induced release of IL-8 and IL-6.	ethyl pyruvate	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
25580060-8	2014	IL-8, NE, MMP-9, HA, and type IV collagen in sputum were also decreased in roxithromycin group compared with the control group (all P &lt; 0.01).	Roxithromycin	75-88	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
24326457-3	2014	With tunable nanoscopic sizes, negligible cytotoxicity and remarkable degradability, they are able to encapsulate doxorubicin (Dox) with inner cavities and bind interleukin-8 (IL-8) small interfering RNA (siRNA) with cationic shells.	Doxorubicin	114-125	C-X-C motif chemokine ligand 8	Homo sapiens	161-174
24326457-3	2014	With tunable nanoscopic sizes, negligible cytotoxicity and remarkable degradability, they are able to encapsulate doxorubicin (Dox) with inner cavities and bind interleukin-8 (IL-8) small interfering RNA (siRNA) with cationic shells.	Doxorubicin	114-125	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
24326457-3	2014	With tunable nanoscopic sizes, negligible cytotoxicity and remarkable degradability, they are able to encapsulate doxorubicin (Dox) with inner cavities and bind interleukin-8 (IL-8) small interfering RNA (siRNA) with cationic shells.	Doxorubicin	127-130	C-X-C motif chemokine ligand 8	Homo sapiens	161-174
24326457-3	2014	With tunable nanoscopic sizes, negligible cytotoxicity and remarkable degradability, they are able to encapsulate doxorubicin (Dox) with inner cavities and bind interleukin-8 (IL-8) small interfering RNA (siRNA) with cationic shells.	Doxorubicin	127-130	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
24326457-5	2014	In vitro studies also showed that the NCs loaded with Dox, IL-8 siRNA and both agents can be readily taken up by PC3 prostate cancer cells, resulting in a significant chemotherapeutic effect and/or IL-8 gene silencing.	Doxorubicin	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	198-202
24697659-4	2014	Among the isolates, three pentacyclic triterpenoids, ursolic acid (1), asiatic acid (3) and terminolic acid (6), together with one tannin casuarinin (17), were found to significantly decrease interleukin-8 (IL-8) production in human colon cancer cells.	pentacyclic	26-37	C-X-C motif chemokine ligand 8	Homo sapiens	192-205
24697659-4	2014	Among the isolates, three pentacyclic triterpenoids, ursolic acid (1), asiatic acid (3) and terminolic acid (6), together with one tannin casuarinin (17), were found to significantly decrease interleukin-8 (IL-8) production in human colon cancer cells.	pentacyclic	26-37	C-X-C motif chemokine ligand 8	Homo sapiens	207-211
24697659-4	2014	Among the isolates, three pentacyclic triterpenoids, ursolic acid (1), asiatic acid (3) and terminolic acid (6), together with one tannin casuarinin (17), were found to significantly decrease interleukin-8 (IL-8) production in human colon cancer cells.	triterpenoids	38-51	C-X-C motif chemokine ligand 8	Homo sapiens	192-205
24697659-4	2014	Among the isolates, three pentacyclic triterpenoids, ursolic acid (1), asiatic acid (3) and terminolic acid (6), together with one tannin casuarinin (17), were found to significantly decrease interleukin-8 (IL-8) production in human colon cancer cells.	triterpenoids	38-51	C-X-C motif chemokine ligand 8	Homo sapiens	207-211
24697659-4	2014	Among the isolates, three pentacyclic triterpenoids, ursolic acid (1), asiatic acid (3) and terminolic acid (6), together with one tannin casuarinin (17), were found to significantly decrease interleukin-8 (IL-8) production in human colon cancer cells.	terminolic acid	92-107	C-X-C motif chemokine ligand 8	Homo sapiens	192-205
24697659-4	2014	Among the isolates, three pentacyclic triterpenoids, ursolic acid (1), asiatic acid (3) and terminolic acid (6), together with one tannin casuarinin (17), were found to significantly decrease interleukin-8 (IL-8) production in human colon cancer cells.	terminolic acid	92-107	C-X-C motif chemokine ligand 8	Homo sapiens	207-211
25242873-0	2014	Purine-metabolizing ectoenzymes control IL-8 production in human colon HT-29 cells.	purine	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
25242873-6	2014	In response to poly (I:C), with or without ATP and/or ADP, HT-29 cells released IL-8 and this secretion was modulated by the presence of NTPDase2 and adenylate kinase.	poly	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
25242873-6	2014	In response to poly (I:C), with or without ATP and/or ADP, HT-29 cells released IL-8 and this secretion was modulated by the presence of NTPDase2 and adenylate kinase.	Adenosine Triphosphate	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
25242873-6	2014	In response to poly (I:C), with or without ATP and/or ADP, HT-29 cells released IL-8 and this secretion was modulated by the presence of NTPDase2 and adenylate kinase.	Adenosine Diphosphate	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
24908314-3	2014	We have recently shown that proteasome inhibition by bortezomib (BZ) specifically increases IL-8 release from metastatic prostate and ovarian cancer cells.	Bortezomib	53-63	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
24908314-3	2014	We have recently shown that proteasome inhibition by bortezomib (BZ) specifically increases IL-8 release from metastatic prostate and ovarian cancer cells.	Bortezomib	65-67	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
24908314-5	2014	IL-8 is localized in the cytoplasm in both cell types, and its protein levels are significantly increased by BZ.	Bortezomib	109-111	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
24908316-0	2014	Quantitative analysis of bortezomib-induced IL-8 gene expression in ovarian cancer cells.	Bortezomib	25-35	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
24908316-5	2014	We have recently shown that in ovarian cancer cells, BZ greatly increases IL-8 expression, while expression of other NFkappaB-regulated cytokines, IL-6 and TNF, is unchanged.	Bortezomib	53-55	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
24908316-6	2014	In this chapter, we describe a protocol that uses real-time qRT-PCR to quantitatively analyze mRNA levels of IL-8 and IL-6 in BZ-treated ovarian cancer cells.	Bortezomib	126-128	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
24201777-8	2014	This effect was related to inhibition of gemcitabine-induced NF-kappaB activation by gabexate mesilate, which prevented RelA/p65 nuclear translocation and resulted in metalloproteinase 2, metalloproteinase 9, vascular endothelial growth factor, and interleukin 8 down-regulation.	gemcitabine	41-52	C-X-C motif chemokine ligand 8	Homo sapiens	249-262
24201777-8	2014	This effect was related to inhibition of gemcitabine-induced NF-kappaB activation by gabexate mesilate, which prevented RelA/p65 nuclear translocation and resulted in metalloproteinase 2, metalloproteinase 9, vascular endothelial growth factor, and interleukin 8 down-regulation.	Gabexate	85-102	C-X-C motif chemokine ligand 8	Homo sapiens	249-262
24988605-8	2014	Inhibitors of CXCL8 (such as N-acetyl-L-cysteine) cause a decrease of exacerbation frequency and clinical symptoms.	Acetylcysteine	29-48	C-X-C motif chemokine ligand 8	Homo sapiens	14-19
25026798-8	2014	Quantitative analysis of urinary IL-6, IL-8, and VEGF levels in patients with SDS may be used to evaluate tubulointerstitial inflammation and to predict the development of interstitial fibrosis.	sds	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
25254233-3	2014	Wet sieving aggregate analysis showed significantly better fragmentation in the NaF, Na-hexa-metaphosphate, and ryegrass root solutions with a mean weight diameter range of 15.5-18.8 mm compared to the 44.2-47.9 mm of the poultry manure, ADB, and FBC treatments.	adb	238-241	C-X-C motif chemokine ligand 8	Homo sapiens	80-83
25254233-3	2014	Wet sieving aggregate analysis showed significantly better fragmentation in the NaF, Na-hexa-metaphosphate, and ryegrass root solutions with a mean weight diameter range of 15.5-18.8 mm compared to the 44.2-47.9 mm of the poultry manure, ADB, and FBC treatments.	4-(3,5-difluorophenyl)benzoic acid	247-250	C-X-C motif chemokine ligand 8	Homo sapiens	80-83
24134915-2	2013	Flavone effects were assessed on soluble pro-inflammatory mediator (IL-8, IL-6, macrophage chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2)-derived PGE2) production and on nuclear factor (NF)-kappaB activation in 3d-confluent and 21d-differentiated Caco-2 cells stimulated with interleukin (IL)-1beta.	flavone	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
25509145-4	2014	Comprehensive assessment of the results after has shown that 3-day HUVEC cultivating in the presence of 1% O2 led to pathological activation of endotheliocytes: increased NO synthesis combined with the marked secretion of endothelin-1, IL-6, IL-8 and TNF-alpha, sVCAM-1, sE-cadherin and of sE-selectin, VEGF-A and bFGF, and slow proliferation.	Oxygen	107-109	C-X-C motif chemokine ligand 8	Homo sapiens	242-246
24502918-4	2014	In this study, when human mast cells (HMC-1 cells) were stimulated with SPs collected from pathogenic wild-type amoebae, interleukin IL-8 mRNA expression and production were significantly increased compared with cells incubated with medium alone.	Sodium phenolsulfonate	72-75	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
24502918-5	2014	Inhibition of CP activity in the SPs with heat or the CP inhibitor E64 resulted in significant reduction of IL-8 production.	Sodium phenolsulfonate	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
24502918-5	2014	Inhibition of CP activity in the SPs with heat or the CP inhibitor E64 resulted in significant reduction of IL-8 production.	E 64	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
24502918-6	2014	Moreover, SPs obtained from inhibitors of cysteine protease (ICP)-overexpressing amoebae with low CP activity showed weaker stimulatory effects on IL-8 production than the wild-type control.	Sodium phenolsulfonate	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
24101016-9	2014	CONCLUSION: In this substudy of a randomized trial comparing minimally invasive and conventional open esophagectomies for cancer, significantly better preserved leukocyte counts and IL-8 levels were observed in the MIE group compared to the open group.	mie	215-218	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
24340081-11	2013	Stimulation of human bronchial cells by AFL led to IL-8 production in a dose-dependent manner.	aflatoxicol	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
24080332-3	2013	Following screening of fifteen metals, zinc and nickel were identified with a marked proinflammatory effect, as determined by ICAM-1 and IL-8 induction, on human umbilical vein endothelial cells (HUVECs).	Nickel	48-54	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
24080332-5	2013	Blockage of TLR-4 signaling by CLI-095, a TLR-4 inhibitor, completely inhibited the nickel-induced ICAM-1 and IL-8 expression and NFkappaB activation.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	31-38	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
24080332-5	2013	Blockage of TLR-4 signaling by CLI-095, a TLR-4 inhibitor, completely inhibited the nickel-induced ICAM-1 and IL-8 expression and NFkappaB activation.	Nickel	84-90	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
24080332-6	2013	The same CLI-095 treatment significantly blocked the zinc-induced IL-8 expression, however with no significant effect on the ICAM-1 expression and a minor inhibitory effect on the NFkappaB activation.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
24080355-4	2013	Moreover, BbV was able to stimulate neutrophil release of proinflammatory mediators such as IL-8 and IL-6 as well as PGE2 and NETs liberation.	BENZYL 2-ACETAMIDO-2-DEOXY-ALPHA-D-GLUCOPYRANOSIDE	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
23994500-11	2013	The organophosphourus compounds affected the release of inflammatory cytokines, such as IL-1ss and IL-8.	organophosphourus	4-21	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
24075485-9	2013	The sivelestat group also showed significantly lower plasma levels of interleukin-8 immediately after bypass (p = 0.041) and interleukin-10 at 15 minutes after removal of the aortic cross-clamp (p = 0.048), and immediately after bypass (p = 0.037).	sivelestat	4-14	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
24060240-8	2013	IL-8 production stimulated with LPS was diminished by vitamin D3 derivatives.	Cholecalciferol	54-64	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
24060240-10	2013	The anti-inflammatory effect of vitamin D3 derivatives was thus associated with diminution of IL-8 production due to increased release of sCD14.	Cholecalciferol	32-42	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
24339939-12	2013	This effect is mediated through the CXCR2 ligands (ENA78, GRO-alpha and IL-8) produced by BSMC.	bsmc	90-94	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
24060240-0	2013	Vitamin D3 derivatives increase soluble CD14 release through ERK1/2 activation and decrease IL-8 production in intestinal epithelial cells.	Cholecalciferol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
24071475-1	2013	Recognition of the harmful effects of sodium fluoride (NaF) on human reproduction is increasing, especially as it relates to female reproduction.	Sodium Fluoride	38-53	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
24298938-4	2013	We found that andrographolide pretreatment significantly restored the glutathione level in CSE-exposed A549 cells, coupled with reduced inhibitor kappaB (IkappaB)-alpha phosphorylation and p65 nuclear translocation and interleukin (IL)-8 and IL-6 secretion.	andrographolide	14-29	C-X-C motif chemokine ligand 8	Homo sapiens	219-237
24298938-8	2013	In contrast, miR-218 silencing enhanced IkappaB-alpha phosphorylation and p65 nuclear accumulation in cells with andrographolide pretreatment and reversed andrographolide-mediated reduction of IL-6 and IL-8 production.	andrographolide	113-128	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
24298938-8	2013	In contrast, miR-218 silencing enhanced IkappaB-alpha phosphorylation and p65 nuclear accumulation in cells with andrographolide pretreatment and reversed andrographolide-mediated reduction of IL-6 and IL-8 production.	andrographolide	155-170	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
23670201-11	2013	Regarding the mechanism of PM2.5 uptake, in both THP-1 and A549 cells, cytochalasin D prevented PM2.5-induced IL-8 mRNA expression and cytokine release, indicating a key role for actin polymerization in particles uptake and that the production of IL-8 correlated with particle phagocytosis.	Cytochalasin D	71-85	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
23670201-11	2013	Regarding the mechanism of PM2.5 uptake, in both THP-1 and A549 cells, cytochalasin D prevented PM2.5-induced IL-8 mRNA expression and cytokine release, indicating a key role for actin polymerization in particles uptake and that the production of IL-8 correlated with particle phagocytosis.	Cytochalasin D	71-85	C-X-C motif chemokine ligand 8	Homo sapiens	247-251
23670201-12	2013	As signal transduction pathway involvement, in both THP-1 and A549 cells, PM2.5-induced IL-8 release could be completely blocked by the selective inhibitor SB203580, indicating a role of p38 MAPK activation.	SB 203580	156-164	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
24032673-3	2013	In the present study, we show in neutrophil-activating chemokine CXCL8 that the highly conserved GP (glycine-proline) motif located distal to both N-terminal and N-loop residues couples Site-I and Site-II interactions.	Glycine	101-108	C-X-C motif chemokine ligand 8	Homo sapiens	65-70
24032673-3	2013	In the present study, we show in neutrophil-activating chemokine CXCL8 that the highly conserved GP (glycine-proline) motif located distal to both N-terminal and N-loop residues couples Site-I and Site-II interactions.	Proline	109-116	C-X-C motif chemokine ligand 8	Homo sapiens	65-70
23933845-3	2013	The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN-gamma and TNF-alpha-NHEK activated cells.	Peptide T	52-54	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
24385947-6	2013	BIRB 796 reduced LPS-mediated IL-8 production in THP-1 cells but not in Raw 264.7 cells.	birb	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
24465106-7	2013	At day 4, IL-8 mean values increased for both IVFO and control groups.	ivfo	46-50	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
23820266-0	2013	gamma-Glutamyltransferase catabolism of S-nitrosoglutathione modulates IL-8 expression in cystic fibrosis bronchial epithelial cells.	S-Nitrosoglutathione	40-60	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
23820266-2	2013	A role for GSNO has been envisaged in the expression of inflammatory cytokines such as IL-8; however, conflicting results have been reported.	S-Nitrosoglutathione	11-15	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
23820266-5	2013	This study was aimed at evaluating the effect of GSNO catabolism mediated by GGT on production of IL-8 in CF transmembrane regulation protein-mutated IB3-1 bronchial cells.	S-Nitrosoglutathione	49-53	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
23820266-6	2013	The rapid, GGT-catalyzed catabolism of GSNO caused a decrease in both basal and lipopolysaccharide-stimulated IL-8 production in IB3-1 cells, by modulating both NF-kappaB and ERK1/2 pathways, along with a decrease in cell proliferation.	S-Nitrosoglutathione	39-43	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
23820266-7	2013	In contrast, a slow decomposition of GSNO produced a significant increase in both cell proliferation and expression of IL-8, the latter possibly through p38-mediated stabilization of IL-8 mRNA.	S-Nitrosoglutathione	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
23820266-7	2013	In contrast, a slow decomposition of GSNO produced a significant increase in both cell proliferation and expression of IL-8, the latter possibly through p38-mediated stabilization of IL-8 mRNA.	S-Nitrosoglutathione	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
23820266-8	2013	Our data suggest that the differential GSNO catabolism mediated by GGT enzyme activity can downregulate the production of IL-8 in CF cells.	S-Nitrosoglutathione	39-43	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
23775574-8	2013	And also immune reaction was less in patients exposed to desflurane anesthesia when compared to propofol anesthesia as indicated by lower plasma concentrations of IL-8 and IL-6.	Desflurane	57-67	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
23775574-8	2013	And also immune reaction was less in patients exposed to desflurane anesthesia when compared to propofol anesthesia as indicated by lower plasma concentrations of IL-8 and IL-6.	Propofol	96-104	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
24157330-6	2013	Using an antibody array approach, curcumin was found to inhibit LPS-induced cytokine production, including MIP-1alpha, MIP-1beta, IL-6, IL-8 (CXCL-8) and GRO-alpha.	Curcumin	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
23933845-3	2013	The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN-gamma and TNF-alpha-NHEK activated cells.	dhurrin	96-103	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
24157330-6	2013	Using an antibody array approach, curcumin was found to inhibit LPS-induced cytokine production, including MIP-1alpha, MIP-1beta, IL-6, IL-8 (CXCL-8) and GRO-alpha.	Curcumin	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	142-148
24157330-7	2013	The inhibitory effect of curcumin on IL-8 production was confirmed by ELISA.	Curcumin	25-33	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
23933845-3	2013	The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN-gamma and TNF-alpha-NHEK activated cells.	prunasin	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
23078188-6	2013	However, only ZnO NPs increased ROS and induced IL-8 release both after 6 and 24 h. Experimental data indicate a main role of chemical composition and solubility in ZnO NPs toxicity.	Zinc Oxide	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
24431789-1	2013	The objective of this study was to evaluate the effect of the addition of stannous fluoride (SnF2) and sodium fluoride (NaF) to luting cements on the retention of provisional crowns.	Sodium Fluoride	103-118	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
24011765-8	2013	In children with C difficile infection, fecal CXCL-5 and IL-8 messenger RNA abundances at diagnosis correlated with persistent diarrhea after 5 days of C difficile infection therapy and with treatment with vancomycin.	Vancomycin	206-216	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
24231103-6	2013	Intake of CLA-enriched butter increased the serum levels of anti-inflammatory IL-10 but reduced transcription factor NFkappaB in blood and serum levels of TNFalpha, IL-2, IL-8 and inactive metalloproteinase-9.	Linoleic Acids, Conjugated	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
24145706-4	2013	Notably, the levels of interleukin (IL)-1beta, IL-8 and monocyte chemotactic protein-1 (MCP-1) in the ELF were significantly increased following the operations which involved the inhalation of sevoflurane and nitrous oxide, although the levels of these molecules were not significantly changed by the inhalation of sevoflurane and air.	Sevoflurane	193-204	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
24145706-6	2013	These observations suggest that the combination of sevoflurane and nitrous oxide induces an inflammatory response (increased production of IL-1beta, IL-8 and MCP-1) and suppresses the anti-inflammatory response (reduced production of IL-12p70) in the local milieu of the airway.	Sevoflurane	51-62	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
24080250-9	2013	Montelukast significantly suppressed the release of IL-8 (p = 0.016), IL-6 (p = 0.006), RANTES (p = 0.002) and IFN-gamma (p = 0.046), in a dose dependent manner in unstimulated cultures but not in those stimulated with IL-1/TNF.	montelukast	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
24145706-6	2013	These observations suggest that the combination of sevoflurane and nitrous oxide induces an inflammatory response (increased production of IL-1beta, IL-8 and MCP-1) and suppresses the anti-inflammatory response (reduced production of IL-12p70) in the local milieu of the airway.	Nitrous Oxide	67-80	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
23742950-7	2013	In human lung fibroblasts inhibition of COX with diclofenac was associated with increased release of IL-8 and IP-10.	Diclofenac	49-59	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
24041966-7	2013	Moreover, PAC were highly resistant to complement-mediated lysis and primarily responded to human complement by releasing IL-6 and IL-8.	pac	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
24080250-10	2013	Withdrawal of Montelukast treatment, was associated with increased IL-8 and RANTES secretion in unstimulated nasal AEC cultured from subjects with asthma and allergic rhinitis but not with asthma alone.	montelukast	14-25	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
24080250-11	2013	CONCLUSIONS: Montelukast treatment for asthma symptoms reversibly suppresses nasal AEC release of pro-inflammatory mediators (i.e. IL-8 and RANTES) but only in those cells cultured from subjects with concomitant allergic rhinitis.	montelukast	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
24285369-4	2013	Purified PMNs from diabetic patients who had been treated with glibenclamide (an ATP-sensitive potassium channel blocker for anti-diabetes therapy), showed reduction of interleukin (IL)-1beta and IL-8 secretion when exposed to B. pseudomallei.	Glyburide	63-76	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
23933549-4	2013	Large equilibrium charge and small dynamic contributions are also characteristic of stretching vibrations in the ionic diatomic molecules, NaF, NaCl, LiF and LiCl.	Lithium Chloride	158-162	C-X-C motif chemokine ligand 8	Homo sapiens	139-142
24076166-10	2013	Carbocysteine in CSE stimulated bronchial epithelial cells, reduced: (1) TLR4, LPS binding and p21; (2) IL-8 mRNA and IL-8 release due to IL-1 stimulation; (3) neutrophil chemotactic migration.	Carbocysteine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
24076166-10	2013	Carbocysteine in CSE stimulated bronchial epithelial cells, reduced: (1) TLR4, LPS binding and p21; (2) IL-8 mRNA and IL-8 release due to IL-1 stimulation; (3) neutrophil chemotactic migration.	Carbocysteine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
23997175-8	2013	Silica exposure activated MAP kinases (ERK and p38) and altered the expression of transcription factors (nF-kappaB and NF-E2-related factor 2), proinflammatory cytokines (interleukin-8 and -6), and apoptotic proteins.	Silicon Dioxide	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	171-191
24278446-4	2013	TcdA and TcdB alter cytoskeletal signaling and trigger the release of CXCL8/IL-8, a potent neutrophil chemoattractant, from intestinal epithelial cells; however, little is known about the surface receptor(s) that mediate these events.	tcda	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	70-75
24278446-4	2013	TcdA and TcdB alter cytoskeletal signaling and trigger the release of CXCL8/IL-8, a potent neutrophil chemoattractant, from intestinal epithelial cells; however, little is known about the surface receptor(s) that mediate these events.	tcda	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
24278446-4	2013	TcdA and TcdB alter cytoskeletal signaling and trigger the release of CXCL8/IL-8, a potent neutrophil chemoattractant, from intestinal epithelial cells; however, little is known about the surface receptor(s) that mediate these events.	trimethylaminocarboxyldihydroboran	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	70-75
24278446-4	2013	TcdA and TcdB alter cytoskeletal signaling and trigger the release of CXCL8/IL-8, a potent neutrophil chemoattractant, from intestinal epithelial cells; however, little is known about the surface receptor(s) that mediate these events.	trimethylaminocarboxyldihydroboran	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
24278446-5	2013	In the current study, we sought to assess whether toxin-induced CXCL8/IL-8 release and barrier dysfunction are driven by the activation of the P2Y6 receptor following the release of UDP, a danger signal, from intoxicated Caco-2 cells.	Uridine Diphosphate	182-185	C-X-C motif chemokine ligand 8	Homo sapiens	64-69
24278446-7	2013	Toxin-induced CXCL8/IL-8 production and release were attenuated in the presence of a selective P2Y6 inhibitor (MRS2578).	N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea	111-118	C-X-C motif chemokine ligand 8	Homo sapiens	14-19
24278446-7	2013	Toxin-induced CXCL8/IL-8 production and release were attenuated in the presence of a selective P2Y6 inhibitor (MRS2578).	N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea	111-118	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
24278446-11	2013	Taken together these data outline a novel role for the P2Y6 receptor in the induction of CXCL8/IL-8 production and barrier dysfunction in response to C. difficile toxin exposure and may provide a new therapeutic target for the treatment of CDI.	1,1'-Carbonyldiimidazole	240-243	C-X-C motif chemokine ligand 8	Homo sapiens	89-94
24063987-13	2013	Evodiamine provoked IL-8 secretion via ERK1/2, SAPK/JNK, JAK2 and AP-1 pathways which could be counteracted by berberine.	evodiamine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
24063987-13	2013	Evodiamine provoked IL-8 secretion via ERK1/2, SAPK/JNK, JAK2 and AP-1 pathways which could be counteracted by berberine.	Berberine	111-120	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
24063987-14	2013	SIGNIFICANCE: Although showing anti-proliferative and anti-migratory activities in AGS cells, evodiamine displayed a potential tendency to promote metastasis of gastric cancer cells by increasing IL-8 secretion and adhesion molecules.	evodiamine	94-104	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
24063987-0	2013	Berberine counteracts enhanced IL-8 expression of AGS cells induced by evodiamine.	Berberine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
24063987-0	2013	Berberine counteracts enhanced IL-8 expression of AGS cells induced by evodiamine.	evodiamine	71-81	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
24063987-1	2013	AIMS: Although showing an anti-tumor activity, evodiamine also up-regulated IL-8 production of human gastric cancer AGS cells.	evodiamine	47-57	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
24063987-10	2013	IL-8 expression and the adhesive ability of AGS cells to HUVECs were significantly increased by evodiamine, but were inhibited after being co-treated with berberine in AGS cells.	evodiamine	96-106	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
24063987-10	2013	IL-8 expression and the adhesive ability of AGS cells to HUVECs were significantly increased by evodiamine, but were inhibited after being co-treated with berberine in AGS cells.	Berberine	155-164	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
24063987-11	2013	As IL-8 was neutralized, increased adhesion of AGS cells to HUVECs induced by evodiamine was abolished.	evodiamine	78-88	C-X-C motif chemokine ligand 8	Homo sapiens	3-7
24237854-7	2013	RESULTS: We found that in ASMCs the TLR3 agonist poly I:C induced IL-8 release was reduced while induced IL-6 release by the TLR7/8 agonist imiquimod was further increased by the presence of piclamilast.	asmcs	26-31	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
24436991-5	2013	Isonahocol E(3) significantly inhibited ET-1-induced cell proliferation, as well as inflammatory mediators, such as interleukin-6 (IL-6) and interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha), and pro-angiogenic factors including metalloproteinases in immortalized human keratinocytes.	isonahocol E(3)	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	141-154
24436991-5	2013	Isonahocol E(3) significantly inhibited ET-1-induced cell proliferation, as well as inflammatory mediators, such as interleukin-6 (IL-6) and interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha), and pro-angiogenic factors including metalloproteinases in immortalized human keratinocytes.	isonahocol E(3)	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
24237854-7	2013	RESULTS: We found that in ASMCs the TLR3 agonist poly I:C induced IL-8 release was reduced while induced IL-6 release by the TLR7/8 agonist imiquimod was further increased by the presence of piclamilast.	Poly I	49-55	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
24062309-6	2013	Antioxidants and low oxygen tension prevented SA IL-1alpha expression and restricted expression of SASP components IL-6 and IL-8.	Oxygen	21-27	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
23877510-2	2013	Recently, a 64-year-old man with biopsy-proven lung cancer underwent an (18)F-NaF PET/CT bone scan due to a shortage of (99m)Tc.	Technetium	125-127	C-X-C motif chemokine ligand 8	Homo sapiens	78-81
24085292-4	2013	However, we found that long-term incubation with PIs (PS-341 or MG132) increased NF-kappaB-regulated gene expression such as COX-2, cIAP2, XIAP, and IL-8 in a dose- and time-dependent manner, which was mediated by phosphorylation of IkappaBalpha and its subsequent degradation via the alternative route, lysosome.	Bortezomib	54-60	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
24085292-4	2013	However, we found that long-term incubation with PIs (PS-341 or MG132) increased NF-kappaB-regulated gene expression such as COX-2, cIAP2, XIAP, and IL-8 in a dose- and time-dependent manner, which was mediated by phosphorylation of IkappaBalpha and its subsequent degradation via the alternative route, lysosome.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	64-69	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
24085292-8	2013	Pretreatment with IKKbeta specific inhibitor, SC-514, partially suppressed IkappaBalpha degradation and IL-8 production by PIs.	SC 514	46-52	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
24071912-3	2013	After further heating, the fluorine substituted compound becomes X-ray amorphous and decomposes to NaF at ~310  C. This work shows that fluorine-substituted borohydrides tend to decompose to more stable compounds, e.g. NaF and BF3 or amorphous products such as closo-boranes, e.g. Na2B12H12.	Fluorine	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
24071912-3	2013	After further heating, the fluorine substituted compound becomes X-ray amorphous and decomposes to NaF at ~310  C. This work shows that fluorine-substituted borohydrides tend to decompose to more stable compounds, e.g. NaF and BF3 or amorphous products such as closo-boranes, e.g. Na2B12H12.	Fluorine	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	219-222
24071912-3	2013	After further heating, the fluorine substituted compound becomes X-ray amorphous and decomposes to NaF at ~310  C. This work shows that fluorine-substituted borohydrides tend to decompose to more stable compounds, e.g. NaF and BF3 or amorphous products such as closo-boranes, e.g. Na2B12H12.	Fluorine	136-144	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
24071912-3	2013	After further heating, the fluorine substituted compound becomes X-ray amorphous and decomposes to NaF at ~310  C. This work shows that fluorine-substituted borohydrides tend to decompose to more stable compounds, e.g. NaF and BF3 or amorphous products such as closo-boranes, e.g. Na2B12H12.	Fluorine	136-144	C-X-C motif chemokine ligand 8	Homo sapiens	219-222
24071912-3	2013	After further heating, the fluorine substituted compound becomes X-ray amorphous and decomposes to NaF at ~310  C. This work shows that fluorine-substituted borohydrides tend to decompose to more stable compounds, e.g. NaF and BF3 or amorphous products such as closo-boranes, e.g. Na2B12H12.	Borohydrides	157-169	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
24071912-3	2013	After further heating, the fluorine substituted compound becomes X-ray amorphous and decomposes to NaF at ~310  C. This work shows that fluorine-substituted borohydrides tend to decompose to more stable compounds, e.g. NaF and BF3 or amorphous products such as closo-boranes, e.g. Na2B12H12.	Borohydrides	157-169	C-X-C motif chemokine ligand 8	Homo sapiens	219-222
24071912-3	2013	After further heating, the fluorine substituted compound becomes X-ray amorphous and decomposes to NaF at ~310  C. This work shows that fluorine-substituted borohydrides tend to decompose to more stable compounds, e.g. NaF and BF3 or amorphous products such as closo-boranes, e.g. Na2B12H12.	boron trifluoride	227-230	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
24071912-3	2013	After further heating, the fluorine substituted compound becomes X-ray amorphous and decomposes to NaF at ~310  C. This work shows that fluorine-substituted borohydrides tend to decompose to more stable compounds, e.g. NaF and BF3 or amorphous products such as closo-boranes, e.g. Na2B12H12.	closo-boranes	261-274	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
24071912-3	2013	After further heating, the fluorine substituted compound becomes X-ray amorphous and decomposes to NaF at ~310  C. This work shows that fluorine-substituted borohydrides tend to decompose to more stable compounds, e.g. NaF and BF3 or amorphous products such as closo-boranes, e.g. Na2B12H12.	na2b12h12	281-290	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
24071912-6	2013	The reversible hydrogen storage capacity tends to decrease possibly due to the formation of NaF and Na2B12H12.	Hydrogen	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
24071912-7	2013	On the other hand, the additive sodium fluoride appears to facilitate hydrogen uptake, prevent foaming, phase segregation and loss of material from the sample container for samples of NaBH4-NaF.	Sodium Fluoride	32-47	C-X-C motif chemokine ligand 8	Homo sapiens	190-193
24179688-0	2013	Effect of cholesterol depletion on interleukin-8 production in human respiratory epithelial cells.	Cholesterol	10-21	C-X-C motif chemokine ligand 8	Homo sapiens	35-48
24179688-6	2013	Mitogen-activated protein kinase (MAPK) inhibitors were used to determine the upstream signaling pathway for IL-8 production in cholesterol-depleted cells.	Cholesterol	128-139	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
24179688-8	2013	IL-8 production was increased in cholesterol-depleted A 549 cells and restored by cholesterol repletion.	Cholesterol	33-44	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
24179688-8	2013	IL-8 production was increased in cholesterol-depleted A 549 cells and restored by cholesterol repletion.	Cholesterol	82-93	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
24179688-9	2013	IL-8 production was decreased by pretreatment with the extracellular signal-regulated kinase (ERK) inhibitor U0126 but not with JNK inhibitor II or the p38 MAPK inhibitor SB202190.	U 0126	109-114	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
24358628-13	2013	Lipoxin A4 inhibited tumor necrosis factor alpha-induced interleukin 8 release from airway epithelial cells via its receptor FPRL-1.	lipoxin A4	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	57-70
23933110-0	2013	Luteolin 8-C-beta-fucopyranoside inhibits invasion and suppresses TPA-induced MMP-9 and IL-8 via ERK/AP-1 and ERK/NF-kappaB signaling in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
23933110-3	2013	We investigated whether LU8C-FP would inhibit MMP-9 activation and IL-8 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 breast cancer cells.	lu8c-fp	24-31	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
23933110-3	2013	We investigated whether LU8C-FP would inhibit MMP-9 activation and IL-8 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	124-127	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
23933110-4	2013	LU8C-FP suppressed TPA-induced MMP-9 and IL-8 secretion and mRNA expression via inhibition of the MAPK signaling pathway and down-regulation of nuclear AP-1 and NF-kappaB.	lu8c-fp	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
23933110-4	2013	LU8C-FP suppressed TPA-induced MMP-9 and IL-8 secretion and mRNA expression via inhibition of the MAPK signaling pathway and down-regulation of nuclear AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
24036252-3	2013	The ensuing Slug-dependent serine 139 phosphorylation of the DNA damage sensor H2AX in breast cancer stem cells induces tumor necrosis factor-alpha and IL-8 mRNAs, whose stability is enhanced by cytoplasmic beta-catenin.	Serine	27-33	C-X-C motif chemokine ligand 8	Homo sapiens	152-156
22183614-8	2013	For the first time, this study demonstrated that the poultry PM-induced IL-8 secretion by human lung epithelial cells was regulated by cPLA2 activation through ERK-mediated serine phosphorylation, suggesting a mechanism of airway inflammation among poultry farm workers.	Serine	173-179	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
24045679-8	2013	RESULTS: Silibinin suppressed the growth of HMC-1 cells and also reduced the production and mRNA expression of pro-inflammatory cytokines such as TNF-alpha, IL-6, and IL-8.	Silybin	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
24072000-12	2013	Through the short-term impact of chlorine e6-PDI on IL-6 and IL-8 secretion, PDI may inhibit the inflammatory cascade in at least keratocyte cultures.	Chlorine	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
23958972-1	2013	The immunotoxicity of the synthetic pyrethroid alpha-cypermethrin (alphaCYP) was assessed in 30 occupationally exposed greenhouse workers and 30 non-exposed controls by comparing plasma levels of IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha, TNF-beta and INF-gamma.	cypermethrin	47-65	C-X-C motif chemokine ligand 8	Homo sapiens	230-234
23934279-5	2013	H2O2 significantly reduced FP-induced GR nuclear localization (3.4+-0.51- vs. 5.7+-0.85-fold increase, P&lt;0.05) and suppression of IL-1beta-induced CXCL8 (62.3+-2.3 vs. 85.1+-7.0%, P&lt;0.05).	Hydrogen Peroxide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	150-155
23916117-7	2013	In cancer NAF samples (containing higher amounts of aluminium salts) we also found a significantly increased levels of pro-inflammatory cytokines (IL-1beta, IL-6, IL-12 p70, and TNF-alpha) and chemoattractant CC and CXC chemokines (IL-8, MIP-1alpha and MCP-1).	aluminium salts	52-67	C-X-C motif chemokine ligand 8	Homo sapiens	232-236
23871663-7	2013	RESULTS: RV-16 infection impaired dexamethasone-dependent (1) inhibition of IL-1beta-induced CXCL8 release, (2) induction of mitogen-activated protein kinase phosphatase 1 gene expression, and (3) binding of GR to GREs in airway epithelial cells.	Dexamethasone	34-47	C-X-C motif chemokine ligand 8	Homo sapiens	93-98
23871663-10	2013	In rhinovirus-infected cells the combination of JNK and IKK2 inhibitors totally restored dexamethasone suppression of CXCL8 release, induction of mitogen-activated protein kinase phosphatase 1 gene expression, and GRalpha nuclear translocation.	Dexamethasone	89-102	C-X-C motif chemokine ligand 8	Homo sapiens	118-123
24002221-0	2013	Pyocyanin from Pseudomonas induces IL-8 production through the PKC and NF-kappaB pathways in U937 cells.	Pyocyanine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
23180322-8	2013	The initial serum CXCL8 levels were significantly associated with the HAQ-DI at the fourth year while the %VC of baseline tended to be negatively associated with HAQ-DI at the fourth year.	haq-di	70-76	C-X-C motif chemokine ligand 8	Homo sapiens	18-23
23911868-4	2013	Although short poly I:C (  1-1.5 kb) induced greater amounts of TNF-alpha, IL-8, and IFN-beta and a stronger antiviral response in myeloid cells, it was a poor inducer in fibroblasts.	Poly I-C	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
24002221-3	2013	An increased release of interleukin-8 (IL-8), a potent neutrophil chemoattractant, in response to pyocyanin may contribute to the marked infiltration of neutrophils and subsequent neutrophil-mediated tissue damage observed in Pseudomonas-associated lung diseases.	Pyocyanine	98-107	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
24002221-6	2013	It was found that pyocyanin increased IL-8 release and mRNA expression in differentiated U937 cells in a concentration- and time-dependent manner.	Pyocyanine	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
24002221-7	2013	Calphostin C (Cal C), a protein kinase C (PKC) inhibitor, and pyrrolidine dithiocarbamate (PDTC) , an NF-kappaB inhibitor, blocked IL-8 expression in a concentration-dependent manner in pyocyanin-induced U937 cells.	pyrrolidine dithiocarbamic acid	62-89	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
24002221-7	2013	Calphostin C (Cal C), a protein kinase C (PKC) inhibitor, and pyrrolidine dithiocarbamate (PDTC) , an NF-kappaB inhibitor, blocked IL-8 expression in a concentration-dependent manner in pyocyanin-induced U937 cells.	pyrrolidine dithiocarbamic acid	91-95	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
24002221-7	2013	Calphostin C (Cal C), a protein kinase C (PKC) inhibitor, and pyrrolidine dithiocarbamate (PDTC) , an NF-kappaB inhibitor, blocked IL-8 expression in a concentration-dependent manner in pyocyanin-induced U937 cells.	Pyocyanine	186-195	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
24002221-8	2013	We concluded that pyocyanin promotes IL-8 secretion and mRNA expression in a concentration- and time-dependent manner and furthermore, that the PKC and NF-kappaBeta signaling pathways may be involved in the expression of IL-8 in pyocyanin-infected PMA-differentiated U937 cells.	Pyocyanine	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
24002221-8	2013	We concluded that pyocyanin promotes IL-8 secretion and mRNA expression in a concentration- and time-dependent manner and furthermore, that the PKC and NF-kappaBeta signaling pathways may be involved in the expression of IL-8 in pyocyanin-infected PMA-differentiated U937 cells.	Pyocyanine	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	221-225
24002221-8	2013	We concluded that pyocyanin promotes IL-8 secretion and mRNA expression in a concentration- and time-dependent manner and furthermore, that the PKC and NF-kappaBeta signaling pathways may be involved in the expression of IL-8 in pyocyanin-infected PMA-differentiated U937 cells.	Pyocyanine	229-238	C-X-C motif chemokine ligand 8	Homo sapiens	221-225
23795990-7	2013	In BAL fluid, the amount of hyaluronan was positively correlated with the percentage of inflammatory cells and the amount of CXCL8.	Hyaluronic Acid	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	125-130
24145180-0	2013	Level of TNF-related apoptosis-inducing-ligand and CXCL8 correlated with 2-[18F]Fluoro-2-deoxy-D-glucose uptake in anti-VEGF treated colon cancers.	Fluorodeoxyglucose F18	73-104	C-X-C motif chemokine ligand 8	Homo sapiens	51-56
24168697-10	2013	The plant extract, compounds ursolic acid and myricitrin (commercially acquired) significantly inhibited the release of inflammatory cytokines IL 8 and TNF alpha by suppressing them by 74 - 99%.	ursolic acid	29-41	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
24168697-10	2013	The plant extract, compounds ursolic acid and myricitrin (commercially acquired) significantly inhibited the release of inflammatory cytokines IL 8 and TNF alpha by suppressing them by 74 - 99%.	myricitrin	46-56	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
24188201-9	2013	RESULTS: CS exposure decreased PPARgamma expression, as well as increased IL-8, LTB4 and TLR4 expression levels in bronchial epithelial cells in vivo and in vitro.	Cesium	9-11	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
24188201-10	2013	Moreover, PPARgamma ligands counteracted CS-induced airway inflammation by reducing IL-8 and LTB4 expression levels that are associated with TLR4 and nuclear factor-kappa B (NF-kappaB).	Cesium	41-43	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
23978569-0	2013	Differential inhibition of signaling pathways by two new imidazo-pyrazoles molecules in fMLF-OMe- and IL8-stimulated human neutrophil.	imidazopyrazole	57-74	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
24250750-0	2013	Primary 1,25-dihydroxyvitamin D3 response of the interleukin 8 gene cluster in human monocyte- and macrophage-like cells.	Calcitriol	8-32	C-X-C motif chemokine ligand 8	Homo sapiens	49-62
24205328-5	2013	GW843682X did not impact Pam3CSK4-induced IL-1beta and IL-8 or LPS-induced IL-1beta, but it down-regulated LPS-induced IL-8 significantly.	5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-((2-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
23978569-2	2013	Compounds 3l and 3r, a new class of arylcarbamoyl-imidazo-pyrazoles derivatives, were described as the first example of compounds able to inhibit human neutrophil chemotaxis induced by both fMLF-OMe and IL8.	arylcarbamoyl-imidazo-pyrazoles	36-67	C-X-C motif chemokine ligand 8	Homo sapiens	203-206
24041930-10	2013	Rivaroxaban and GB83 prevented upregulation of PARs, ICAM-1, LOX-1, IL-8, and activation of MAP kinases.	Rivaroxaban	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
24146965-4	2013	After addition of calcium to cultured keratinocytes, the immunological responses induced by imiquimod, such as activation of NF-kappaB and induction of TNF-alpha and IL-8, were more rapid and stronger.	Calcium	18-25	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
24041930-10	2013	Rivaroxaban and GB83 prevented upregulation of PARs, ICAM-1, LOX-1, IL-8, and activation of MAP kinases.	gb83	16-20	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
23811328-4	2013	The results showed that, on acute or chronic exposure to arsenite, HBE cells over-expressed the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1beta (IL-1beta).	arsenite	57-65	C-X-C motif chemokine ligand 8	Homo sapiens	146-159
23811328-4	2013	The results showed that, on acute or chronic exposure to arsenite, HBE cells over-expressed the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1beta (IL-1beta).	arsenite	57-65	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
23811328-6	2013	Moreover, IL-6 and IL-8 were essential for the malignant progression of arsenite-transformed HBE cells.	arsenite	72-80	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
23981042-6	2013	Also, that APDs inhibited the production of LPS-stimulated macrophages IL-6 and IL-8 suggests that risperidone and clozapine may inhibit inflammation.	Risperidone	99-110	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
24083094-8	2013	Only succinic acid resulted in a significant increase in interleukin-8 production by infected macrophages.	Succinic Acid	5-18	C-X-C motif chemokine ligand 8	Homo sapiens	57-70
23876538-12	2013	RESULT(S): With parthenolide pretreatment, TNF-alpha-induced IL-8 gene and protein expression in ESCs were diminished.	parthenolide	16-28	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
23904051-1	2013	Hierarchical assembly of Ti(IV)/Sn(II)-doped SnO2 nanosheets along titanate nanowires serving as both sacrificial templates and a Ti(IV) source is demonstrated, using SnCl2 as a tin precursor and Sn(II) dopants and NaF as the morphology controlling agent.	sn(ii)	32-38	C-X-C motif chemokine ligand 8	Homo sapiens	215-218
23904051-1	2013	Hierarchical assembly of Ti(IV)/Sn(II)-doped SnO2 nanosheets along titanate nanowires serving as both sacrificial templates and a Ti(IV) source is demonstrated, using SnCl2 as a tin precursor and Sn(II) dopants and NaF as the morphology controlling agent.	Tin(IV) oxide	45-49	C-X-C motif chemokine ligand 8	Homo sapiens	215-218
24083678-8	2013	Sulindac sulfide also induced activation of the AP-1 transcription factor, which co-operated with NF-kappaB in up-regulating IL-8.	sulindac sulfide	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
24409733-4	2013	The method was successfully employed in the toxic effect test of NaF, NaCl, KBr and NaBF4 on luciferase.	Sodium tetrafluoroborate	84-89	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
25002916-11	2013	Deferoxamine significantly reduced cytotoxicity and IL-6 and IL-8 secretion whereas Polymyxin B did not.	Deferoxamine	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
24198747-13	2013	Taken together, our results suggest that BFT induced IL-8 secretion may occur by the following process: E-cadherin cleavage, disruption of cellular interactions, activation of the beta-catenin pathway and IL-8 expression.	SCHEMBL13664687	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	205-209
23981042-6	2013	Also, that APDs inhibited the production of LPS-stimulated macrophages IL-6 and IL-8 suggests that risperidone and clozapine may inhibit inflammation.	Clozapine	115-124	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
24772960-2	2013	The study was based on the hypothesis that poultry PM would induce the release of inflammatory cytokine interleukin-8 (IL-8) by respiratory epithelial cells under the upstream regulation by cytosolic phospholipase A2 (cPLA2) activation and subsequent formation of cyclooxygenase (COX)- and lipoxygenase (LOX)-catalyzed arachidonic acid (AA) metabolites (eicosanoids).	Arachidonic Acid	319-335	C-X-C motif chemokine ligand 8	Homo sapiens	104-117
24198747-4	2013	BFT induces E-cadherin cleavage, cell rounding, activation of the beta-catenin pathway and secretion of IL-8 in colonic epithelial cells.	SCHEMBL13664687	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
24772960-2	2013	The study was based on the hypothesis that poultry PM would induce the release of inflammatory cytokine interleukin-8 (IL-8) by respiratory epithelial cells under the upstream regulation by cytosolic phospholipase A2 (cPLA2) activation and subsequent formation of cyclooxygenase (COX)- and lipoxygenase (LOX)-catalyzed arachidonic acid (AA) metabolites (eicosanoids).	Arachidonic Acid	319-335	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
24772960-2	2013	The study was based on the hypothesis that poultry PM would induce the release of inflammatory cytokine interleukin-8 (IL-8) by respiratory epithelial cells under the upstream regulation by cytosolic phospholipase A2 (cPLA2) activation and subsequent formation of cyclooxygenase (COX)- and lipoxygenase (LOX)-catalyzed arachidonic acid (AA) metabolites (eicosanoids).	Eicosanoids	354-365	C-X-C motif chemokine ligand 8	Homo sapiens	104-117
24772960-2	2013	The study was based on the hypothesis that poultry PM would induce the release of inflammatory cytokine interleukin-8 (IL-8) by respiratory epithelial cells under the upstream regulation by cytosolic phospholipase A2 (cPLA2) activation and subsequent formation of cyclooxygenase (COX)- and lipoxygenase (LOX)-catalyzed arachidonic acid (AA) metabolites (eicosanoids).	Eicosanoids	354-365	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
24772960-6	2013	Poultry PM also significantly induced release of IL-8 by the cells in a dose- and time-dependent manner, which was significantly attenuated by the calcium chelating agents, antioxidants and COX- and LOX-specific inhibitors.	Calcium	147-154	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
24772960-7	2013	The current study for the first time revealed that the poultry PM-induced IL-8 release from the respiratory epithelial cells was regulated upstream by reactive oxygen species, cPLA2-, COX- and LOX-derived eicosanoid lipid signal mediators.	Reactive Oxygen Species	151-174	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
24772960-7	2013	The current study for the first time revealed that the poultry PM-induced IL-8 release from the respiratory epithelial cells was regulated upstream by reactive oxygen species, cPLA2-, COX- and LOX-derived eicosanoid lipid signal mediators.	Eicosanoids	205-215	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
24198747-8	2013	Prior studies have suggested that BFT induces IL-8 expression by inducing E-cadherin cleavage; cells that do not express E-cadherin do not secrete IL-8 in response to BFT.	SCHEMBL13664687	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
24198747-11	2013	We also show that EDTA-mediated disruption of E-cadherin interactions without E-cadherin degradation was sufficient to induce IL-8 secretion.	Edetic Acid	18-22	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
23575601-8	2013	Furthermore, dioscorin suppressed IL-8 secretion and reduced changes of adhesion molecule expressions in H(2)O(2)-injured A549 cells.	dioscorin	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
24198747-12	2013	Finally, we determined that HT29/C1 cells treated with LiCl (beta-catenin activator) induced IL-8 secretion in a dose-dependent and time-dependent manner.	Lithium Chloride	55-59	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
24198747-13	2013	Taken together, our results suggest that BFT induced IL-8 secretion may occur by the following process: E-cadherin cleavage, disruption of cellular interactions, activation of the beta-catenin pathway and IL-8 expression.	SCHEMBL13664687	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
23793449-7	2013	In the propofol group, IL-6 and IL-8 were significantly increased at T3 compared to T1.	Propofol	7-15	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
23594598-3	2013	BTH inhibited the release of some of the key psoriatic cytokines such as tumor necrosis factor alpha, IL-8, IL-6, and CCL27 through the downregulation of NF-kappaB in normal human keratinocytes.	bth	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
23733596-9	2013	Results showed that supplementation with LC and Na2S reduced NF-kappaB phosphorylation and the secretion of TNF-alpha, MCP-1, IL-8, IL-1beta, and IP-10.	sodium sulfide	48-52	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
23488973-6	2013	For PcP patients, BALF levels of IL-8, IL-8/IL-10 ratio and IL-8/TGF-beta1 ratio and blood levels of IL-8 and IL-8/IL-10 ratio were significantly higher in the patients with PaO2/FiO2 &lt; 200 mmHg than in those with PaO2/FiO2 &gt; 200 mmHg.	pao2	174-178	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
23460381-12	2013	Because IL-8 induced an increase in EAA level, it is suggested that the EAA level reflects the primed state of polymorphonuclear leukocytes.	ethyl acetoacetate	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	8-12
23799521-9	2013	There was a significant reduction in IL-8 concentration 24 hours after BMA associated with the concomitant administration of steroids and methotrexate.	bma	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
23799521-9	2013	There was a significant reduction in IL-8 concentration 24 hours after BMA associated with the concomitant administration of steroids and methotrexate.	Steroids	125-133	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
23799521-9	2013	There was a significant reduction in IL-8 concentration 24 hours after BMA associated with the concomitant administration of steroids and methotrexate.	Methotrexate	138-150	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
23488973-6	2013	For PcP patients, BALF levels of IL-8, IL-8/IL-10 ratio and IL-8/TGF-beta1 ratio and blood levels of IL-8 and IL-8/IL-10 ratio were significantly higher in the patients with PaO2/FiO2 &lt; 200 mmHg than in those with PaO2/FiO2 &gt; 200 mmHg.	pao2	174-178	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
23488973-6	2013	For PcP patients, BALF levels of IL-8, IL-8/IL-10 ratio and IL-8/TGF-beta1 ratio and blood levels of IL-8 and IL-8/IL-10 ratio were significantly higher in the patients with PaO2/FiO2 &lt; 200 mmHg than in those with PaO2/FiO2 &gt; 200 mmHg.	pao2	174-178	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
23488973-6	2013	For PcP patients, BALF levels of IL-8, IL-8/IL-10 ratio and IL-8/TGF-beta1 ratio and blood levels of IL-8 and IL-8/IL-10 ratio were significantly higher in the patients with PaO2/FiO2 &lt; 200 mmHg than in those with PaO2/FiO2 &gt; 200 mmHg.	pao2	174-178	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
24378059-9	2013	(3) The reduction of TNFalpha and IL-8 levels were positively correlated with reduction of NF-kappaB activity after intervention of rolipram in group B3 (r = 0.874, P &lt; 0.01; r = 0.561, P &lt; 0.05 respectively).	Rolipram	132-140	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
23727622-1	2013	Chronic exposure to arsenic can generate reactive oxidative species, which can induce certain proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8).	Arsenic	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	194-207
23727622-1	2013	Chronic exposure to arsenic can generate reactive oxidative species, which can induce certain proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8).	Arsenic	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
23727622-10	2013	The present results also showed a significant increase in UC risk in subjects with the IL-8 -251 T/T genotype for each SD increase in urinary total arsenic and MMA%.	Arsenic	148-155	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
23727622-11	2013	In contrast, a significant decrease in UC risk was found in subjects who carried the IL-8 -251 T/T genotype for each SD increase in DMA%.	N-myristoyl-alaninol	132-135	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
23954527-7	2013	Montelukast treatment prevented IL-8 release and heterologous beta2-adrenoceptor desensitization in human BSMC exposed to monocyte-derived MPs by blocking NF-kappaB nuclear translocation.	montelukast	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
23499888-7	2013	NHBE cells increased IL-8 production in a dose-dependent manner in response to CSC while DHBE cells did not show any significant difference and had a much lower production of IL-8 in response to CSC compared to NHBE cells.	dhbe	89-93	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
23499888-11	2013	DHBE cells exhibit a dampened IL-8 release, indicating that COPD is associated with a reduced capacity of airway epithelial cells to respond to foreign material.	dhbe	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
23969730-9	2013	Further experiments identified that ATP could promote IL-8 and Snail expression and inhibit E-cadherin and Claudin-1 expression.	Adenosine Triphosphate	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
24223512-1	2013	The aim of this paper was to describe the in vitro effect of sodium fluoride (NaF) on the specific activity of the major erythrocyte antioxidant enzymes, as well as on the membrane malondialdehyde concentration, as indicators of oxidative stress.	Sodium Fluoride	61-76	C-X-C motif chemokine ligand 8	Homo sapiens	78-81
24223512-5	2013	The presence of vitamin E partially reversed the toxic effects of NaF on erythrocytes.	Vitamin E	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	66-69
24223512-6	2013	These findings suggest that NaF induces oxidative stress in erythrocytes in vitro, and this stress is partially reversed by the presence of vitamin E.	Vitamin E	140-149	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
23988269-0	2013	Direct determination of the NaF/AlF3 molar ratio by Raman spectroscopy in NaF-AlF3-CaF2 melts at 1000  C. For the last 40 years, Raman spectroscopy has been very useful in investigating the structure of corrosive molten salts, such as the cryolite-based melts widely used as electrolyte in the Hall-Heroult process.	aluminum fluoride	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
24066150-7	2013	RESULTS: Roflumilast and Roflumilast-N-oxide concentration-dependently reduced the release of TNF-alpha and chemokines CCL2, CCL3, CCL4, CXCL9 and CXCL10 from LPS-stimulated human lung explants, whereas CXCL1, CXCL5 and CXCL8 release was not altered.	roflumilast N-oxide	25-44	C-X-C motif chemokine ligand 8	Homo sapiens	220-225
24039842-5	2013	Our data showed that cyanidin-3-glucoside reduced cytokine-induced inflammation in intestinal cells, in terms of NO, PGE2 and IL-8 production and of iNOS and COX-2 expressions, at a much lower concentration than 5-aminosalicylic acid, suggesting a higher anti-inflammatory efficiency.	cyanidin-3-o-glucoside	21-41	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
24049670-0	2013	The role of calcium, NF-kappaB and NFAT in the regulation of CXCL8 and IL-6 expression in Jurkat T-cells.	Calcium	12-19	C-X-C motif chemokine ligand 8	Homo sapiens	61-66
24049670-6	2013	Interestingly, NF-kappaB activation by heat killed E. coli, as well as CXCL8 and IL-6 expression was significantly suppressed following addition of the calcium ionophore.	Calcium	152-159	C-X-C motif chemokine ligand 8	Homo sapiens	71-76
23448158-7	2013	In NaCl solution with 0.02 M NaF, NiTi suffer localized corrosion, while beta titanium alloys remained passive.	nacl solution	3-16	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
23590581-4	2013	RESULTS: MgSO4 exposure increased intracellular magnesium levels, reducing the frequency of THP-1 cells producing IL-1beta, IL-8, and TNF-alpha following LPS stimulation.	Magnesium Sulfate	9-14	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
23448158-11	2013	When 0.02 and 0.04 M of NaF were added to the NaCl solution, NiTi presented localized corrosion.	nacl solution	46-59	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
23475935-9	2013	NTBI levels were higher after transfusion (p&lt;0.01) returning to pretransfusion levels by 24 h. Post-transfusion NTBI level correlated with the age of transfused blood (p&lt;0.001) and was positively correlated with plasma MDA (p=0.01) but not IL-1beta, IL-6, IL8 or TNFalpha.	ntbi	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	262-265
23475935-9	2013	NTBI levels were higher after transfusion (p&lt;0.01) returning to pretransfusion levels by 24 h. Post-transfusion NTBI level correlated with the age of transfused blood (p&lt;0.001) and was positively correlated with plasma MDA (p=0.01) but not IL-1beta, IL-6, IL8 or TNFalpha.	ntbi	115-119	C-X-C motif chemokine ligand 8	Homo sapiens	262-265
23845509-6	2013	Moreover, GTN down-regulated translocation of the p50/p65 heterodimer to the nucleus, prevented binding of NF-kappaB to its DNA response element and reduced TNF-alpha-activated interleukin-8 (IL-8) expression.	goniothalamin	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	177-190
23578643-2	2013	Our results demonstrated that high glucose-induced oxidative stress in HUVECs was mainly mediated through activation of reactive oxygen species (ROS), Jun N-kinase 2/3 (JNK2/3) and plasma interleukin-8 (IL-8), and inactivation of phosphorylated protein kinase B (P-Akt).	Glucose	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	188-201
23578643-2	2013	Our results demonstrated that high glucose-induced oxidative stress in HUVECs was mainly mediated through activation of reactive oxygen species (ROS), Jun N-kinase 2/3 (JNK2/3) and plasma interleukin-8 (IL-8), and inactivation of phosphorylated protein kinase B (P-Akt).	Glucose	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
23578643-4	2013	Furthermore, 5-HMF rapidly inhibited high glucose-induced activation of IL-8, a downstream activator of P-Akt.	Glucose	42-49	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
23845509-6	2013	Moreover, GTN down-regulated translocation of the p50/p65 heterodimer to the nucleus, prevented binding of NF-kappaB to its DNA response element and reduced TNF-alpha-activated interleukin-8 (IL-8) expression.	goniothalamin	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
23900994-6	2013	In this review we summarise the ability of curcumin to interfere with signalling pathways Wnt, Hedgehog, Notch, Signal Transducers and Activator (STAT) and interleukin-8, and report curcumin-induced changes in function and properties of cancer stem cells.	Curcumin	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	156-169
23751319-6	2013	Compared with the LPS control group, APS (100 mug/mL) or SAPS (100 mug/mL) administration decreased the expression of TNF-alpha, IL-1beta and IL-8.	saps	57-61	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
23679817-0	2013	Inhibition by new glucocorticoid antedrugs [16alpha, 17alpha-d] isoxazoline and [16alpha, 17alpha-d]-3"-hydroxy-iminoformyl isoxazoline derivatives of chemotaxis and CCL26, CCL11, IL-8, and RANTES secretion.	glucocorticoid antedrugs	18-42	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
23679817-0	2013	Inhibition by new glucocorticoid antedrugs [16alpha, 17alpha-d] isoxazoline and [16alpha, 17alpha-d]-3"-hydroxy-iminoformyl isoxazoline derivatives of chemotaxis and CCL26, CCL11, IL-8, and RANTES secretion.	[16alpha, 17alpha-d] isoxazoline	43-75	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
23679817-0	2013	Inhibition by new glucocorticoid antedrugs [16alpha, 17alpha-d] isoxazoline and [16alpha, 17alpha-d]-3"-hydroxy-iminoformyl isoxazoline derivatives of chemotaxis and CCL26, CCL11, IL-8, and RANTES secretion.	[16alpha, 17alpha-d]-3"-hydroxy-iminoformyl isoxazoline	80-135	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
23894194-0	2013	Proteasome inhibition by bortezomib increases IL-8 expression in androgen-independent prostate cancer cells: the role of IKKalpha.	Bortezomib	25-35	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
23894194-4	2013	In this article, we report that proteasome inhibition by BZ unexpectedly increases IL-8 expression in androgen-independent prostate cancer PC3 and DU145 cells, whereas expression of other NF-kappaB-regulated genes is inhibited or unchanged.	Bortezomib	57-59	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
23894194-5	2013	The BZ-increased IL-8 expression is associated with increased in vitro p65 NF-kappaB DNA binding activity and p65 recruitment to the endogenous IL-8 promoter.	Bortezomib	4-6	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
23894194-5	2013	The BZ-increased IL-8 expression is associated with increased in vitro p65 NF-kappaB DNA binding activity and p65 recruitment to the endogenous IL-8 promoter.	Bortezomib	4-6	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
23894194-6	2013	In addition, proteasome inhibition induces a nuclear accumulation of IkappaB kinase (IKK)alpha, and inhibition of IKKalpha enzymatic activity significantly attenuates the BZ-induced p65 recruitment to IL-8 promoter and IL-8 expression, demonstrating that the induced IL-8 expression is mediated, at least partly, by IKKalpha.	Bortezomib	171-173	C-X-C motif chemokine ligand 8	Homo sapiens	201-205
23894194-6	2013	In addition, proteasome inhibition induces a nuclear accumulation of IkappaB kinase (IKK)alpha, and inhibition of IKKalpha enzymatic activity significantly attenuates the BZ-induced p65 recruitment to IL-8 promoter and IL-8 expression, demonstrating that the induced IL-8 expression is mediated, at least partly, by IKKalpha.	Bortezomib	171-173	C-X-C motif chemokine ligand 8	Homo sapiens	219-223
23894194-6	2013	In addition, proteasome inhibition induces a nuclear accumulation of IkappaB kinase (IKK)alpha, and inhibition of IKKalpha enzymatic activity significantly attenuates the BZ-induced p65 recruitment to IL-8 promoter and IL-8 expression, demonstrating that the induced IL-8 expression is mediated, at least partly, by IKKalpha.	Bortezomib	171-173	C-X-C motif chemokine ligand 8	Homo sapiens	219-223
23894194-7	2013	Together, these data provide the first evidence, to our knowledge, for the gene-specific increase of IL-8 expression by proteasome inhibition in prostate cancer cells and suggest that targeting both IKKalpha and the proteasome may increase BZ effectiveness in treatment of androgen-independent prostate cancer.	Bortezomib	240-242	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
23629852-7	2013	Cobalt increased secretion of IL8 and MCP1 significantly, and upregulated the expression of ICAM-1 in ECs compared to stimulation by chromium and controls.	Cobalt	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
23661232-6	2013	Resveratrol significantly decreased both basal and interferon-gamma (IFN-gamma) (200 ng/ml)-stimulated levels of MCP-1, IL-6, and IL-8 and significantly attenuated both basal and IFN-gamma-stimulated activity of ERK.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
23661232-8	2013	Therefore, resveratrol is thought to inhibit production of MCP-1, IL-6, and IL-8 in HCASMCs through attenuating ERK activity.	Resveratrol	11-22	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
23661232-0	2013	Inhibitory effects of resveratrol on MCP-1, IL-6, and IL-8 production in human coronary artery smooth muscle cells.	Resveratrol	22-33	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
23661232-5	2013	Basal levels of monocyte chemoattractant protein-1 (MCP-1), interleukin (IL)-6, and IL-8 were significantly decreased in the presence of resveratrol at 1-50 muM in a concentration-dependent manner and were significantly decreased in the presence of U0126, an ERK inhibitor.	Resveratrol	137-148	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
23890848-4	2013	RESULTS: A combination of EPA and DHA significantly reduced the concentration of IL-8 and IL-6 released into the supernatant compared to untreated controls (p&lt;0.001).	Eicosapentaenoic Acid	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
23765639-6	2013	METHODS: Evaluation of the effect of tadalafil and vardenafil on secretion of interleukin 8 (IL-8, a surrogate marker of prostate inflammation) by human myofibroblast prostatic cells (hBPH) exposed to different inflammatory stimuli.	Vardenafil Dihydrochloride	51-61	C-X-C motif chemokine ligand 8	Homo sapiens	78-91
23765639-8	2013	RESULTS: In vitro treatment with tadalafil or vardenafil on hBPH reduced IL-8 secretion induced by either TNFalpha or metabolic factors, including oxidized low-density lipoprotein, oxLDL, to the same extent as a PDE5-insensitive PKG agonist Sp-8-Br-PET-cGMP.	Tadalafil	33-42	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
23765639-8	2013	RESULTS: In vitro treatment with tadalafil or vardenafil on hBPH reduced IL-8 secretion induced by either TNFalpha or metabolic factors, including oxidized low-density lipoprotein, oxLDL, to the same extent as a PDE5-insensitive PKG agonist Sp-8-Br-PET-cGMP.	Vardenafil Dihydrochloride	46-56	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
24068928-6	2013	Furthermore, the UL76-mediated induction of IL-8 requires ATM and is correlated with the phosphorylation of NEMO on serine 85, indicating that UL76 activates NF-kB pathway by the DNA Damage response, similar to the impact of genotoxic drugs.	Serine	116-122	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
23890848-4	2013	RESULTS: A combination of EPA and DHA significantly reduced the concentration of IL-8 and IL-6 released into the supernatant compared to untreated controls (p&lt;0.001).	Dihydroalprenolol	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
23890848-5	2013	Stimulation of PPARgamma with troglitazone reduced IL-8 production, and the PPARgamma antagonist GW9662 partially reversed this effect.	Troglitazone	30-42	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
23792671-7	2013	The most remarkable gene induced by DON and 15ADON was inflammatory chemokine IL-8 and thus mRNA expression and secretion of IL-8 were analyzed by PCR and ELISA.	deoxynivalenol	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
23792671-7	2013	The most remarkable gene induced by DON and 15ADON was inflammatory chemokine IL-8 and thus mRNA expression and secretion of IL-8 were analyzed by PCR and ELISA.	deoxynivalenol	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
23792671-7	2013	The most remarkable gene induced by DON and 15ADON was inflammatory chemokine IL-8 and thus mRNA expression and secretion of IL-8 were analyzed by PCR and ELISA.	15-acetyldeoxynivalenol	44-50	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
24003340-14	2013	Although not fully evaluated in pNETs, biomarkers associated with response to sunitinib in several tumor types include soluble vascular endothelial growth factor receptor 2 and 3, interleukin 8, and stromal cell-derived factor 1alpha.	Sunitinib	78-87	C-X-C motif chemokine ligand 8	Homo sapiens	180-193
23792671-7	2013	The most remarkable gene induced by DON and 15ADON was inflammatory chemokine IL-8 and thus mRNA expression and secretion of IL-8 were analyzed by PCR and ELISA.	15-acetyldeoxynivalenol	44-50	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
23792671-8	2013	Both DON and acetylated DONs could induce mRNA expression and production of IL-8.	deoxynivalenol	5-8	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
23792671-8	2013	Both DON and acetylated DONs could induce mRNA expression and production of IL-8.	DONS	24-28	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
23792671-9	2013	In particular, ELISA assay showed that the ability to produce IL-8 was ranked as 3ADON&lt;DON&lt;15ADON.	15-acetyldeoxynivalenol	97-103	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
23792671-10	2013	Our results indicated that 15ADON caused the highest permeability and highest IL-8 secretion among DON, 3ADON, and 15ADON in human intestinal cell.	15-acetyldeoxynivalenol	27-33	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
23792671-10	2013	Our results indicated that 15ADON caused the highest permeability and highest IL-8 secretion among DON, 3ADON, and 15ADON in human intestinal cell.	deoxynivalenol	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
23792671-10	2013	Our results indicated that 15ADON caused the highest permeability and highest IL-8 secretion among DON, 3ADON, and 15ADON in human intestinal cell.	3-acetyldeoxynivalenol	104-109	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
23766431-7	2013	RESULTS: Etidronate, at the lower concentration, significantly increased the expression of interleukin (IL)-6 (p=0.03) and IL-8 (p=0.04).	Etidronic Acid	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
23991101-7	2013	This massive in vitro evidence supports the hypotheses that SMF-exposure (i) is harmful to lymphocytes in itself, (ii) suppresses the release of pro-inflammatory cytokines IL-6, IL-8, and TNF-alpha, and (iii) assists the production of anti-inflammatory cytokine IL-10; thus providing a background mechanism of the earlier in vivo demonstrated anti-inflammatory effects of SMF-exposure.	smf	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
23831464-0	2013	Differential regulation of CC chemokine ligand 2 and CXCL8 by antifungal agent nystatin in macrophages.	Nystatin	79-87	C-X-C motif chemokine ligand 8	Homo sapiens	53-58
23831464-4	2013	However, nystatin dose-dependently increased CCL2 and CXCL8 expression at the mRNA and protein levels.	Nystatin	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	54-59
23831464-5	2013	To understand the molecular mechanisms of the antifungal agent, we identified cellular factors activated by nystatin and those involved in nystatin-induced upregulation of CCL2 and CXCL8.	Nystatin	139-147	C-X-C motif chemokine ligand 8	Homo sapiens	181-186
23831464-8	2013	Nystatin-mediated CXCL8 expression was attenuated in the presence of Akt inhibitor IV and SP6001250.	Nystatin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	18-23
23831464-8	2013	Nystatin-mediated CXCL8 expression was attenuated in the presence of Akt inhibitor IV and SP6001250.	sp6001250	90-99	C-X-C motif chemokine ligand 8	Homo sapiens	18-23
23831464-9	2013	These results indicate that exposure of human macrophages to nystatin can lead to differential regulation of CCL2 and CXCL8 via the activation of multiple cellular kinases.	Nystatin	61-69	C-X-C motif chemokine ligand 8	Homo sapiens	118-123
23831464-10	2013	We propose that upregulation of CCL2 and CXCL8 contributes to pharmacological effects of nystatin.	Nystatin	89-97	C-X-C motif chemokine ligand 8	Homo sapiens	41-46
23865744-0	2013	Influence of sodium halides (NaF, NaCl, NaBr, NaI) on the photocatalytic performance of hydrothermally synthesized hematite photoanodes.	hematite photoanodes	115-135	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
23865744-3	2013	In this study, we prepared hematite photoanodes hydrothermally from precursor solutions of 0.1 M FeCl3 at pH 1.55 with a background electrolyte of 1.0 M sodium halide (NaF, NaCl, NaBr, or NaI).	hematite photoanodes	27-47	C-X-C motif chemokine ligand 8	Homo sapiens	168-171
24062615-7	2013	RESULTS: We have demonstrated that budesonide concentration-dependently (10(-10)-10(-7) M) inhibited IL-6, IL-8, MMP-1, and MMP-3 release by HFL-1 cells in response to IL-1beta plus TNF-alpha.	Budesonide	35-45	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
23977231-6	2013	Inhibition studies using antisense RNA and the pharmacological agent BAY-117082 confirmed the involvement of NF-kappaB in IL-6, IL-8, and IL-1beta secretion.	3-(4-methylphenylsulfonyl)-2-propenenitrile	69-79	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
23977237-6	2013	Furthermore, ATROSAB inhibited release of IL-6 and IL-8 from HeLa and HT1080 cells, respectively, induced by TNF or lymphotoxin alpha (LTalpha).	atrosab	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
23578198-2	2013	Our present study revealed that sunitinib-treated RCC cells exhibit senescence characteristics including increased SA-beta-gal activity, DcR2 and Dec1 expression, and senescence-associated secretary phenotype (SASP) such as proinflammatory cytokines interleukin (IL)-1alpha, IL-6 and IL-8 secretion.	Sunitinib	32-41	C-X-C motif chemokine ligand 8	Homo sapiens	284-288
23766431-9	2013	Alendronate, at the highest concentration, significantly increased the expression of IL-8 (p=0.02) and decreased the expression of eotaxin (p=0.02).	Alendronate	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
22354777-0	2013	Phosphorylation of histone H3 at serine 10 has an essential role in arsenite-induced expression of FOS, EGR1 and IL8 mRNA in cultured human cell lines.	arsenite	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
23930605-10	2013	Pre-clinical trials have shown vitamin D to not only decrease BPH cell and prostate cell proliferation alone, but also when induced by known growth promoting molecules such as IL-8, Des (1-3) IGF-1, testosterone and dihydrotestosterone.	Vitamin D	31-40	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
23607720-8	2013	In neutrophils, 15-epi-LXA4 showed a moderate reduction of interleukin (IL)-8-mediated neutrophil chemotaxis but no effect on neutrophil survival was observed.	lipoxin A4	22-27	C-X-C motif chemokine ligand 8	Homo sapiens	59-77
23607720-10	2013	In conclusion, 15-epi-LXA4 is not a functional agonist or an antagonist of FPR2/ALX or CysLT1, shows no effect on IL-8-induced neutrophil survival and produces only moderate inhibition in IL-8-mediated neutrophil migration.	lipoxin A4	15-26	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
23590633-9	2013	In HMC-1 cells, [6]-shogaol inhibited the production of TNF-alpha, IL-6 and IL-8, as well as the activation of nuclear factor-kappaB (NF-kappaB) and phosphorylation of JNK in compound 48/80-induced HMC-1 cells.	shogaol	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
22354777-0	2013	Phosphorylation of histone H3 at serine 10 has an essential role in arsenite-induced expression of FOS, EGR1 and IL8 mRNA in cultured human cell lines.	Serine	33-39	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
23649946-5	2013	We review studies showing a relationship between elevated aqueous VEGF, monocyte chemoattractant protein -1, interleukin 6, or interleukin 8 in association with DME and as predictors of DME.	dme	161-164	C-X-C motif chemokine ligand 8	Homo sapiens	127-140
23794083-9	2013	Using this technique, we have measured changes in LJPs for diluted solutions of NaCl, LiCl, KCl, CsCl and NaF, obtaining excellent agreement within +-0.1 mV of predicted values, calculated using ion activities.	ljps	50-54	C-X-C motif chemokine ligand 8	Homo sapiens	106-109
23794083-10	2013	Our de novo LJP measurements of biionic combinations of the above undiluted salts, and NaI and NaF (with halide anions I- and F-), generally also gave excellent agreement with predicted values.	halide	105-111	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
23456484-5	2013	We also found that although dexamethasone suppressed the release of these two cytokines, mast cells recruitment, and mucus hypersecretion, it actually increased neutrophil infiltration and the level of keratinocyte-derived chemokine (mKC), a functional homolog of human IL-8.	Dexamethasone	28-41	C-X-C motif chemokine ligand 8	Homo sapiens	270-274
23456484-7	2013	The elevated IL-8 level was suppressed by BAY11-7082, a selective NF-kappaB inhibitor, but not by dexamethasone.	3-(4-methylphenylsulfonyl)-2-propenenitrile	42-52	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
23456484-8	2013	These results suggest that increased IL-8 (mKC) levels may be involved in steroid-resistant neutrophilic airway inflammation through an NF-kappaB-dependent pathway.	Steroids	74-81	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
22354777-6	2013	U0126 treatment significantly reduced constitutive mRNA expression of FOS and EGR1, and dramatically suppressed the induction of FOS, EGR1 and IL8 mRNA in iAs(III)-treated cells.	U 0126	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	143-146
22354777-8	2013	When the histone H3 nonphosphorylatable mutant of serine 10 (S10A) was overexpressed in cells, iAs(III) induction of FOS, EGR1and IL8 expression was significantly decreased as compared with wild-type cells.	Serine	50-56	C-X-C motif chemokine ligand 8	Homo sapiens	130-133
23817417-7	2013	Combined celecoxib and TNF-alpha blockade more effectively suppressed the proinflammatory loop than did single treatment, as shown by lower IL-6, IL-8, matrix metalloproteinase-1 and matrix metalloproteinase-3 production.	Celecoxib	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
23779254-5	2013	The pharmacologic inhibitors of ERK, U0126 and PD98059, effectively reduced IL-8 expression and the active forms of ERK signaling molecules, as detected by anti-phosphorylated p44/42 antibody.	U 0126	37-42	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
23779254-5	2013	The pharmacologic inhibitors of ERK, U0126 and PD98059, effectively reduced IL-8 expression and the active forms of ERK signaling molecules, as detected by anti-phosphorylated p44/42 antibody.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	47-54	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
24051972-5	2013	RESULTS: After six months of DHA supplementation inflammatory marker levels had diminished: interleukin 8 (IL-8) and Tumour Necrosis Factor Alfa (TNF-alpha) in serum, and calprotectin in stools.	dehydroacetic acid	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	92-105
23720457-10	2013	IL-8 release induced by S-LPS, which requires CD14 to activate TLR4, was blocked by bosentan and BQ788.	Bosentan	84-92	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
23720457-10	2013	IL-8 release induced by S-LPS, which requires CD14 to activate TLR4, was blocked by bosentan and BQ788.	BQ 788	97-102	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
23712703-4	2013	However, the receptor for advanced glycation end products (RAGE) blocker RAGE-Ab (5 mug/ml) or 10 muM c-Jun N-terminal kinases (JNK) inhibitor SP600125 could inhibit HMGB1-induced the release of inflammation cytokines including TNF-alpha, IL-8, IL-10, and MCP-1 in a dose-dependent manner.	pyrazolanthrone	143-151	C-X-C motif chemokine ligand 8	Homo sapiens	239-243
24051972-5	2013	RESULTS: After six months of DHA supplementation inflammatory marker levels had diminished: interleukin 8 (IL-8) and Tumour Necrosis Factor Alfa (TNF-alpha) in serum, and calprotectin in stools.	dehydroacetic acid	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
23936340-3	2013	To identify inhibitors of the NOD2 signaling pathway, we utilized a cell-based screening approach and identified a benzimidazole diamide compound designated GSK669 that selectively inhibited an MDP-stimulated, NOD2-mediated IL-8 response without directly inhibiting RIP2 kinase activity.	benzimidazole diamide	115-136	C-X-C motif chemokine ligand 8	Homo sapiens	224-228
23764888-5	2013	Arazyme inhibited the secretion of IL-6 and IL-8 due to phorbol 12-myristate 13-acetate and calcium ionophores in human mast cells.	Tetradecanoylphorbol Acetate	56-87	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
23764888-5	2013	Arazyme inhibited the secretion of IL-6 and IL-8 due to phorbol 12-myristate 13-acetate and calcium ionophores in human mast cells.	Calcium	92-99	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
24303127-5	2013	Tulobuterol reduced the RV14 titers and RNA levels; the concentrations of cytokines, including interleukin (IL)-1beta, IL-6, and IL-8, in the supernatants; and susceptibility to RV14 infection.	tulobuterol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
23784034-14	2013	HCl exposure increased the levels of IL-8 and the release of LDH, and induced apoptosis in BEAS-2B cells.	Hydrochloric Acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
23189959-4	2013	Lactate production, glucose uptake and the percentage of oocytes reaching metaphase II decreased in a dose-dependent manner in the presence of the pharmacological (NaF) or the physiological (ATP) inhibitors of glycolysis (p &lt; 0.05).	Lactic Acid	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	164-167
23936340-3	2013	To identify inhibitors of the NOD2 signaling pathway, we utilized a cell-based screening approach and identified a benzimidazole diamide compound designated GSK669 that selectively inhibited an MDP-stimulated, NOD2-mediated IL-8 response without directly inhibiting RIP2 kinase activity.	gsk669	157-163	C-X-C motif chemokine ligand 8	Homo sapiens	224-228
23526216-0	2013	Role of hypoxia-inducible factor 1, alpha subunit and cAMP-response element binding protein 1 in synergistic release of interleukin 8 by prostaglandin E2 and nickel in lung fibroblasts.	Dinoprostone	137-153	C-X-C motif chemokine ligand 8	Homo sapiens	120-133
23578767-6	2013	Increased IL-8 secretion required HMC-fibroblast intercellular contact, was enhanced by serum and was blocked by the gap junction inhibitor beta-glycyrrhetinic.	beta-glycyrrhetinic	140-159	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
23578767-8	2013	IL-8 secretion by fibroblasts was strongly promoted by hyaluronic acid.	Hyaluronic Acid	55-70	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
23578767-9	2013	Pre-treatment of HMC with thapsigargin provoked 15-fold higher IL-8 production by fibroblasts in co-cultures.	Thapsigargin	26-38	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
23403077-8	2013	The growth of the tumor spheres could also be reduced by the CXCR2 specific inhibitor SB225002 or the PI3K/AKT inhibitor LY294002, indicating that the endogenously produced CXCL8 plays an autocrine role in the growth of the tumor spheres.	SB 225002	86-94	C-X-C motif chemokine ligand 8	Homo sapiens	173-178
23403077-8	2013	The growth of the tumor spheres could also be reduced by the CXCR2 specific inhibitor SB225002 or the PI3K/AKT inhibitor LY294002, indicating that the endogenously produced CXCL8 plays an autocrine role in the growth of the tumor spheres.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	C-X-C motif chemokine ligand 8	Homo sapiens	173-178
23403077-9	2013	Further mechanistic studies revealed that the gene expression of CXCL8 could be reduced by the MIF specific small interfering RNA (siRNA) or NF-kappaB inhibitor parthenolide, and the growth of tumor spheres was also reduced after MIF siRNA transfection.	parthenolide	161-173	C-X-C motif chemokine ligand 8	Homo sapiens	65-70
23844176-2	2013	Nickel compounds are well established human carcinogens, however, little is known about the influence of nickel on the spontaneous secretion of IL-8 in oral squamous cell carcinoma (OSCC) cells.	Nickel	105-111	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
23844176-3	2013	The aim of the present study was to investigate whether Ni(2+) ions can influence on IL-8 secretion by OSCC.	Nickel(2+)	56-62	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
23844176-11	2013	Our results demonstrated that, on the contrary to our expectations, Ni(2+) ions inhibited the spontaneous secretion of IL-8.	Nickel(2+)	68-74	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
23844176-12	2013	As IL-8 reduction was observed in a transcriptional level, we performed the luciferase assay and the data indicated that Ni(2+) ions reduced the NF-kappaB activity.	Nickel(2+)	121-127	C-X-C motif chemokine ligand 8	Homo sapiens	3-7
23895055-7	2013	Using HUVECs we demonstrated that tylophorine inhibited VEGF-stimulated inflammatory responses including IL-6, IL-8, TNF-alpha, IFN-gamma, MMP-2 and NO secretion.	tylophorine	34-45	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
23770363-0	2013	Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
23770363-7	2013	1,25 (OH)2 vitamin D caused significantly (p&lt;0.05) lower secretion of IL-8 and MCP-1, and lower ROS levels in monocytes exposed to control and HG-treated monocytes.	1,25 (oh)2 vitamin d	0-20	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
23874538-2	2013	Lung epithelial cell released IL-8 plays a crucial role in CS induced lung inflammation.	Cesium	59-61	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
23874538-3	2013	CS and cigarette smoke extracts (CSE) both induce IL-8 secretion and subsequently, IL-8 recruits inflammatory cells into the lung parenchyma.	Cesium	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
23874538-3	2013	CS and cigarette smoke extracts (CSE) both induce IL-8 secretion and subsequently, IL-8 recruits inflammatory cells into the lung parenchyma.	Cesium	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
23742030-12	2013	Microdialysis levels of histamine, IL-6 and IL-8 assessed 1-3 h after cold challenge were significantly (P &lt; 0.05) decreased following up-dosing with 80 mg bilastine.	bilastine	159-168	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
23526216-0	2013	Role of hypoxia-inducible factor 1, alpha subunit and cAMP-response element binding protein 1 in synergistic release of interleukin 8 by prostaglandin E2 and nickel in lung fibroblasts.	Nickel	158-164	C-X-C motif chemokine ligand 8	Homo sapiens	120-133
23526216-3	2013	The current study sought to identify the molecular events underlying Ni-induced alterations in PGE2 signaling and its effects on IL-8 production.	Dinoprostone	95-99	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
23526216-4	2013	PGE2 synergistically enhances Ni-induced IL-8 release from HLF in a concentration-dependent manner.	Dinoprostone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
23883807-10	2013	Nine of 14 patients in the FF group (64%) reported slight to total relief of nasal symptoms, and this subgroup had a significant decrease in IL-8 levels in nasal secretions after 6 weeks of treatment (850.7 +- 207.2 pg/mL versus 1608 +- 696.5 pg/mL; p = 0.03) compared with baseline.	fluticasone furoate	27-29	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
23526216-6	2013	PGE2 and forskolin stimulated cAMP, but it was only in the presence of Ni-induced hypoxia-inducible factor 1, alpha subunit (HIF1A) that these agents stimulated IL-8 release.	Dinoprostone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
23526216-6	2013	PGE2 and forskolin stimulated cAMP, but it was only in the presence of Ni-induced hypoxia-inducible factor 1, alpha subunit (HIF1A) that these agents stimulated IL-8 release.	Colforsin	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
23603753-8	2013	Rebamipide also suppressed TNFalpha-induced expression of interleukin-6 and interleukin-8 at the mRNA and protein levels and inhibited the TNFalpha-induced degradation of IkappaBalpha.	rebamipide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	76-89
23583258-3	2013	This report concerns the marked up-regulation in differentiated CaCo-2 colonic epithelial cells of two key inflammatory interleukins, IL-6 and IL-8, caused by a mixture of oxysterols representative of a high cholesterol diet.	Oxysterols	172-182	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
23583258-3	2013	This report concerns the marked up-regulation in differentiated CaCo-2 colonic epithelial cells of two key inflammatory interleukins, IL-6 and IL-8, caused by a mixture of oxysterols representative of a high cholesterol diet.	Cholesterol	208-219	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
24174716-3	2013	These bacterial species initiate the production of various cytokines such as interleukin-8 and TNF-alpha, further causing an increase in number and activity of polymorphonucleocytes (PMN) along with these cytokines, PMNs also produce reactive oxygen species (ROS) superoxide via the respiratory burst mechanism as the part of the defence response to infection.	Reactive Oxygen Species	234-257	C-X-C motif chemokine ligand 8	Homo sapiens	77-90
23683858-4	2013	ppTGRL were found to increase the secretion of chemoattractants, including monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1alpha and -1beta and IL-8, by HMDM and to have a stimulatory effect on monocyte chemotaxis.	pptgrl	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
23628225-6	2013	The BALF concentrations of IL-1beta; IL-8; interferon-gamma-induced protein 10; regulated upon activation, normal T-cell expressed and secreted; neutrophil elastase; and pepsin were higher in patients with BOS (p &lt; 0.05).	N-[4-(Aminosulfonyl)phenyl]-2-Mercaptobenzamide	206-209	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
23564008-0	2013	The concentrations of IL-8 and IL-6 in gingival crevicular fluid during nickel-chromium alloy porcelain crown restoration.	Nickel	72-78	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
23564008-0	2013	The concentrations of IL-8 and IL-6 in gingival crevicular fluid during nickel-chromium alloy porcelain crown restoration.	Chromium	79-87	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
23758162-3	2013	EXPERIMENTAL APPROACH: Corticosteroid sensitivity was determined by IC50/EC50 of dexamethasone (Dex) on TNF-alpha-induced CXCL8 production in U937 monocytic cell line and peripheral blood mononuclear cells (PBMC) from COPD patients.	Dexamethasone	81-94	C-X-C motif chemokine ligand 8	Homo sapiens	122-127
23758162-3	2013	EXPERIMENTAL APPROACH: Corticosteroid sensitivity was determined by IC50/EC50 of dexamethasone (Dex) on TNF-alpha-induced CXCL8 production in U937 monocytic cell line and peripheral blood mononuclear cells (PBMC) from COPD patients.	Dexamethasone	96-99	C-X-C motif chemokine ligand 8	Homo sapiens	122-127
23211751-5	2013	Furthermore, adrenaline significantly reduced the expression of chemokine CXCL8_L1 (a functional homolog of mammalian IL-8) and its receptors (CXCR1 and CXCR2), indicating changes in leukocyte recruitment after stress.	Epinephrine	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
23564008-1	2013	We explored gum irritation and cytotoxicity caused by nickel-chromium (Ni-Cr) alloy porcelain by interleukin-8 (IL-8), interleukin-6 (IL-6) and gingival crevicular fluid (GCF) volumes at different time points peri-crown restoration.	nichrome	54-69	C-X-C motif chemokine ligand 8	Homo sapiens	97-110
24174716-3	2013	These bacterial species initiate the production of various cytokines such as interleukin-8 and TNF-alpha, further causing an increase in number and activity of polymorphonucleocytes (PMN) along with these cytokines, PMNs also produce reactive oxygen species (ROS) superoxide via the respiratory burst mechanism as the part of the defence response to infection.	Reactive Oxygen Species	259-262	C-X-C motif chemokine ligand 8	Homo sapiens	77-90
23564008-1	2013	We explored gum irritation and cytotoxicity caused by nickel-chromium (Ni-Cr) alloy porcelain by interleukin-8 (IL-8), interleukin-6 (IL-6) and gingival crevicular fluid (GCF) volumes at different time points peri-crown restoration.	nichrome	54-69	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
23564008-5	2013	The total amount and concentrations of IL-8 and IL-6 per site, GCF volumes increased after nickel-chromium (Ni-Cr) alloy-porcelain crown restoration, and reached its peak at the third month as the GCF volume increased by 52.20 %, the total amount and concentrations of IL-8 increased by 112.11 and 22.75 %; the total amount and concentrations of IL-6 increased by 77.66 and 17.17 % when compared to baseline.	nichrome	91-106	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
24174716-3	2013	These bacterial species initiate the production of various cytokines such as interleukin-8 and TNF-alpha, further causing an increase in number and activity of polymorphonucleocytes (PMN) along with these cytokines, PMNs also produce reactive oxygen species (ROS) superoxide via the respiratory burst mechanism as the part of the defence response to infection.	Superoxides	264-274	C-X-C motif chemokine ligand 8	Homo sapiens	77-90
23564008-5	2013	The total amount and concentrations of IL-8 and IL-6 per site, GCF volumes increased after nickel-chromium (Ni-Cr) alloy-porcelain crown restoration, and reached its peak at the third month as the GCF volume increased by 52.20 %, the total amount and concentrations of IL-8 increased by 112.11 and 22.75 %; the total amount and concentrations of IL-6 increased by 77.66 and 17.17 % when compared to baseline.	nichrome	108-113	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
23748240-0	2013	Repression of miR-143 mediates Cr (VI)-induced tumor angiogenesis via IGF-IR/IRS1/ERK/IL-8 pathway.	chromium hexavalent ion	31-38	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
23564008-7	2013	The increase in the total amount and the concentrations of IL-8 and IL-6 and GCF volume may be related to the cytotoxicity induced by Ni-Cr alloy.	nichrome	134-139	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
23564008-8	2013	The significant increase of IL-8 concentration in females indicates that more attention should be given to women during Ni-Cr alloy porcelain crown restoration.	nichrome	120-125	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
23629517-4	2013	Results indicate that robust changes in the expression of the proinflammatory cytokine interleukin 8 (IL8) and the vascular cell adhesion molecule 1 (VCAM1) occur within 5h of exposure to CAS.	cas	188-191	C-X-C motif chemokine ligand 8	Homo sapiens	87-100
23629517-4	2013	Results indicate that robust changes in the expression of the proinflammatory cytokine interleukin 8 (IL8) and the vascular cell adhesion molecule 1 (VCAM1) occur within 5h of exposure to CAS.	cas	188-191	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
23475986-8	2013	Although naringenin significantly attenuated IL-1beta-induced IL-6 and IL-8 mRNA expression and release, there was no effect of curcumin and apigenin.	naringenin	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
22899541-3	2013	In concentrations of 5 muM-20 muM, PGG demonstrated statistically significant inhibition of ROS generation, IL-8 secretion and beta2 integrin expression in stimulated neutrophils.	pgg	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
23617551-10	2013	Inhaled budesonide significantly reduced LPS-induced IL-1beta, IL-6, IL-8 and TNF-alpha secretion, while inhaled formoterol had no such effect; however when combined, the inhibitory effect of budesonide was significantly increased by formoterol.	Budesonide	8-18	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
23629517-6	2013	Analysis shows that CAS induced the release of IL8 and IL6.	cas	20-23	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
23791132-7	2013	In VTE patients atorvastatin decreased IL-6 (p=0.0003), IL-8 (p=0.003) and P-selectin (p&lt;0.0001), but increased IL-10 (p=0.001), with no association with C-reactive protein or cholesterol-lowering effects.	Atorvastatin	16-28	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
23680662-5	2013	Here we report that a KS disaccharide, [SO3(-)-6]Galbeta1-4[SO3(-)-6]GlcNAc, designated as L4, suppressed the production of Interleukin-8 (IL-8) stimulated by flagellin, a Toll-like receptor (TLR) 5 agonist, in normal human bronchial epithelial (NHBE) cells.	ks disaccharide	22-37	C-X-C motif chemokine ligand 8	Homo sapiens	124-137
23774942-0	2013	A soft coral natural product, 11-episinulariolide acetate, inhibits gene expression of cyclooxygenase-2 and interleukin-8 through attenuation of calcium signaling.	11-episinulariolide acetate	30-57	C-X-C motif chemokine ligand 8	Homo sapiens	108-121
23774942-0	2013	A soft coral natural product, 11-episinulariolide acetate, inhibits gene expression of cyclooxygenase-2 and interleukin-8 through attenuation of calcium signaling.	Calcium	145-152	C-X-C motif chemokine ligand 8	Homo sapiens	108-121
23680662-5	2013	Here we report that a KS disaccharide, [SO3(-)-6]Galbeta1-4[SO3(-)-6]GlcNAc, designated as L4, suppressed the production of Interleukin-8 (IL-8) stimulated by flagellin, a Toll-like receptor (TLR) 5 agonist, in normal human bronchial epithelial (NHBE) cells.	ks disaccharide	22-37	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
23680662-5	2013	Here we report that a KS disaccharide, [SO3(-)-6]Galbeta1-4[SO3(-)-6]GlcNAc, designated as L4, suppressed the production of Interleukin-8 (IL-8) stimulated by flagellin, a Toll-like receptor (TLR) 5 agonist, in normal human bronchial epithelial (NHBE) cells.	[so3(-)-6]galbeta1-4[so3(-)-6]glcnac	39-75	C-X-C motif chemokine ligand 8	Homo sapiens	124-137
23611835-1	2013	SB225002 (SB) is an IL-8 receptor B (IL-8RB) antagonist that has previously been shown to inhibit IL-8-based cancer cell invasion, and to possess in vivo anti-inflammatory and anti-nociceptive effects.	SB 225002	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
23611835-1	2013	SB225002 (SB) is an IL-8 receptor B (IL-8RB) antagonist that has previously been shown to inhibit IL-8-based cancer cell invasion, and to possess in vivo anti-inflammatory and anti-nociceptive effects.	SB 225002	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
23611835-10	2013	In summary, the present study introduced SB as a promising antitumor agent which has the potential to exert its activity through dual mechanisms involving microtubules targeting and interference with IL-8-drivin cancer progression.	SB 225002	41-43	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
23578390-1	2013	Sodium fluoride (NaF) is widely used for the treatment of dental caries and dentin hypersensitivity.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
23578390-5	2013	Exposure of cells to 4mM NaF for 24h induced caspase-3 activation, ultrastructural alterations, and resulted in the translocation of Bax to the mitochondria and the release of cytochrome c from the mitochondrial inter-membrane space into the cytosol, indicating that fluoride-mediated apoptosis is mitochondria-dependent.	Fluorides	267-275	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
23680662-5	2013	Here we report that a KS disaccharide, [SO3(-)-6]Galbeta1-4[SO3(-)-6]GlcNAc, designated as L4, suppressed the production of Interleukin-8 (IL-8) stimulated by flagellin, a Toll-like receptor (TLR) 5 agonist, in normal human bronchial epithelial (NHBE) cells.	[so3(-)-6]galbeta1-4[so3(-)-6]glcnac	39-75	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
23740581-8	2013	RESULTS: The levels of IL-8 and TNF-alpha in EBC, the levels of exhaled NO, and the percentage of neutrophils in induced sputum were significantly elevated in C and B compared with A; the EBC pH level was significantly reduced in C and B compared with A.	NSC638702	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
23740581-9	2013	The EBC levels of IL-8, TNF-alpha, pH, the level of exhaled NO, and the percentage of neutrophils correlated significantly with age.	NSC638702	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
23600826-7	2013	Similarly, co-incubation of fatty acids with glucose diminished secretion of IL-10, IFN-gamma and CCL2 (monocyte chemotactic protein-1), while IL-8 was up-regulated (P &lt; 0 001).	Fatty Acids	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
23161900-11	2013	Finally, DAPT significantly decreased VEGF/Ang2 induced IL-6, IL-8, MMP2 and 9 expressions in RA synovial explants.	dapt	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
23602068-9	2013	Methylprednisolone significantly lowered concentrations of proinflammatory cytokines IL-6 and IL-8 and raised levels of anti-inflammatory IL-10.	Methylprednisolone	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
23633491-6	2013	Together these findings offer a rationale for dual inhibition of IL-6/IL-8 signaling as a therapeutic strategy to improve outcomes for patients with TNBCs.	tnbcs	149-154	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
23885223-6	2013	Therefore, these results provide immunological information about amorphous silica nanoparticles and suggest that amorphous silica nanoparticles can evoke innate immune reactions in human monocytes through production of IL-1beta and IL-8.	Silicon Dioxide	123-129	C-X-C motif chemokine ligand 8	Homo sapiens	232-236
23605466-6	2013	More recently, another molecular probe 18 F-sodium fluoride (18 F-NaF) was introduced for PET imaging, which targets active microcalcifications in atherosclerotic plaques.	Sodium Fluoride	43-59	C-X-C motif chemokine ligand 8	Homo sapiens	66-69
23602200-7	2013	Only ROS generation was highly affected by the blockade of PMN-secreted TNF-alpha or IL-8.	Reactive Oxygen Species	5-8	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
23199585-7	2013	CAM and AZM induced a dose-dependent suppression of spontaneous TNF-alpha, sTNFR2, IL-6, IL-8 and CCL18 production (p&lt;0.05).	Clarithromycin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
23199585-7	2013	CAM and AZM induced a dose-dependent suppression of spontaneous TNF-alpha, sTNFR2, IL-6, IL-8 and CCL18 production (p&lt;0.05).	Azithromycin	8-11	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
23199585-9	2013	CAM and AZM significantly and dose-dependently attenuated the LPS-stimulated production of sTNFR1, sTNFR2, IL-8 and CCL18 (p&lt;0.05).	Clarithromycin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
23199585-9	2013	CAM and AZM significantly and dose-dependently attenuated the LPS-stimulated production of sTNFR1, sTNFR2, IL-8 and CCL18 (p&lt;0.05).	Azithromycin	8-11	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
23659606-3	2013	Results obtained by scanning electron microscopy (SEM) and SEM/energy dispersive X-ray analyses proved that the hydroxyapatite and bioactive glass-containing toothpastes were highly efficient in promoting enamel remineralization by formation of deposits and a protective layer on the surface of the demineralized enamel, whereas the toothpaste containing 8% strontium acetate and 1040 ppm fluoride as NaF had little, if any, remineralization potential.	Durapatite	112-126	C-X-C motif chemokine ligand 8	Homo sapiens	401-404
23588209-9	2013	TES inhibited UVB-induced production of the pro-inflammatory cytokines interleukin (IL)-6 and IL-8 in a dose-dependent manner.	tectroside	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
23588209-10	2013	In addition, TES inhibited the expression of cyclooxygenase (COX)-2 and the phosphorylation of c-Jun NH2-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) MAPKs, suggesting that it inhibits the secretion of the pro-inflammatory cytokines IL-6 and IL-8 and COX-2 expression by blocking MAPK phosphorylation.	tectroside	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	267-271
23862231-6	2013	CONCLUSION: The levels of IL-8 and COX-2 in EPS indirectly reflect those in the prostate tissue.	eps	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
23620238-11	2013	Co-treatment with DHT significantly inhibited oxLDL-induced secretion of IL-8, whilst an AR-antagonist, bicalutamide, reversed DHT effects.	Dihydrotestosterone	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
23274767-8	2013	However, the activity of the cationic nanoparticles on the IL-8 promoter and NF-kappaB translocation is lost when cholesterol is depleted from A549 cells before particle exposure, which suggests that cationic nanoparticles rely on membrane cholesterol integrity to disrupt cellular signaling.	Cholesterol	114-125	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
23274767-8	2013	However, the activity of the cationic nanoparticles on the IL-8 promoter and NF-kappaB translocation is lost when cholesterol is depleted from A549 cells before particle exposure, which suggests that cationic nanoparticles rely on membrane cholesterol integrity to disrupt cellular signaling.	Cholesterol	240-251	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
23458894-0	2013	Crotonaldehyde-exposed macrophages induce IL-8 release from airway epithelial cells through NF-kappaB and AP-1 pathways.	2-butenal	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
23458896-1	2013	We have previously observed that 1-nitropyrene (1-NP) and its amine metabolite 1-aminopyrene (1-AP) induce differential chemokine responses in human bronchial epithelial cells (BEAS-2B) characterized by maximum responses for CXCL8 (IL-8) and CCL5 (RANTES), respectively.	1-nitropyrene	33-46	C-X-C motif chemokine ligand 8	Homo sapiens	225-230
23458896-1	2013	We have previously observed that 1-nitropyrene (1-NP) and its amine metabolite 1-aminopyrene (1-AP) induce differential chemokine responses in human bronchial epithelial cells (BEAS-2B) characterized by maximum responses for CXCL8 (IL-8) and CCL5 (RANTES), respectively.	1-nitropyrene	33-46	C-X-C motif chemokine ligand 8	Homo sapiens	232-236
23458896-1	2013	We have previously observed that 1-nitropyrene (1-NP) and its amine metabolite 1-aminopyrene (1-AP) induce differential chemokine responses in human bronchial epithelial cells (BEAS-2B) characterized by maximum responses for CXCL8 (IL-8) and CCL5 (RANTES), respectively.	1-nitropyrene	48-52	C-X-C motif chemokine ligand 8	Homo sapiens	225-230
23458896-1	2013	We have previously observed that 1-nitropyrene (1-NP) and its amine metabolite 1-aminopyrene (1-AP) induce differential chemokine responses in human bronchial epithelial cells (BEAS-2B) characterized by maximum responses for CXCL8 (IL-8) and CCL5 (RANTES), respectively.	1-nitropyrene	48-52	C-X-C motif chemokine ligand 8	Homo sapiens	232-236
23458896-1	2013	We have previously observed that 1-nitropyrene (1-NP) and its amine metabolite 1-aminopyrene (1-AP) induce differential chemokine responses in human bronchial epithelial cells (BEAS-2B) characterized by maximum responses for CXCL8 (IL-8) and CCL5 (RANTES), respectively.	1-aminopyrene	79-92	C-X-C motif chemokine ligand 8	Homo sapiens	225-230
23458896-1	2013	We have previously observed that 1-nitropyrene (1-NP) and its amine metabolite 1-aminopyrene (1-AP) induce differential chemokine responses in human bronchial epithelial cells (BEAS-2B) characterized by maximum responses for CXCL8 (IL-8) and CCL5 (RANTES), respectively.	1-aminopyrene	79-92	C-X-C motif chemokine ligand 8	Homo sapiens	232-236
23458896-1	2013	We have previously observed that 1-nitropyrene (1-NP) and its amine metabolite 1-aminopyrene (1-AP) induce differential chemokine responses in human bronchial epithelial cells (BEAS-2B) characterized by maximum responses for CXCL8 (IL-8) and CCL5 (RANTES), respectively.	1-aminopyrene	94-98	C-X-C motif chemokine ligand 8	Homo sapiens	225-230
23458896-1	2013	We have previously observed that 1-nitropyrene (1-NP) and its amine metabolite 1-aminopyrene (1-AP) induce differential chemokine responses in human bronchial epithelial cells (BEAS-2B) characterized by maximum responses for CXCL8 (IL-8) and CCL5 (RANTES), respectively.	1-aminopyrene	94-98	C-X-C motif chemokine ligand 8	Homo sapiens	232-236
23458896-4	2013	However, at a low concentration (1 muM) where neither 1-NP, 1-AP nor unsubstituted pyrene had any effect on chemokine responses, we found that all three PAHs potentiated CXCL8 and CCL5 responses induced by the TLR3 ligand polyinosinic:polycytidylic acid (Poly I:C) in BEAS-2B cells.	Polycyclic Aromatic Hydrocarbons	153-157	C-X-C motif chemokine ligand 8	Homo sapiens	170-175
23632478-8	2013	CONCLUSION: Lenalidomide favours a uniform TNF-alpha and IL-8 inflammatory and IGF-1 secretory profile of myeloma cells, an observation that raises important questions for therapeutic approaches incorporating the agent.	Lenalidomide	12-24	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
23458894-7	2013	Furthermore, BEAS-2B and A549 cells directly treated with crotonaldehyde induced increase in IL-8 production.	2-butenal	58-72	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
23458894-8	2013	These data suggest that crotonaldehyde is capable of directly stimulating the production of IL-8 in both macrophages and airway epithelial cells.	2-butenal	24-38	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
23458894-9	2013	Crotonaldehyde-stimulated macrophages also amplify the inflammatory response by enhancing IL-8 release from airway epithelial cells mediated by NF-kappaB and AP-1 pathways through a mechanism involving TNF-alpha and IL-1beta.	2-butenal	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
23443656-5	2013	We also demonstrate that TgMIF can elicit IL-8 production from human peripheral blood mononuclear cells while also activating ERK MAPK pathways in murine bone marrow-derived macrophages.	tgmif	25-30	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
22915623-7	2013	RESULTS: Simvastatin decreased IL-17-induced IL-6, IL-8, CX3CL-1, RANTES mRNA and CX3CL-1 and CCL20 production.	Simvastatin	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
23007230-0	2013	Paediatric acute generalized exanthematous pustulosis induced by paracetamol with high serum levels of interleukin-8 and -22: a case report.	Acetaminophen	65-76	C-X-C motif chemokine ligand 8	Homo sapiens	103-124
23357535-4	2013	Thrombin-induced increases in IL-8/CXCL8 release and kappaB-luciferase activity were inhibited by the Shc small interfering RNA (siRNA), p66Shc siRNA, GW 5074 (a Raf-1 inhibitor), and PD98059 (a mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitor).	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	151-158	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
23357535-4	2013	Thrombin-induced increases in IL-8/CXCL8 release and kappaB-luciferase activity were inhibited by the Shc small interfering RNA (siRNA), p66Shc siRNA, GW 5074 (a Raf-1 inhibitor), and PD98059 (a mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitor).	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	151-158	C-X-C motif chemokine ligand 8	Homo sapiens	35-40
23357535-4	2013	Thrombin-induced increases in IL-8/CXCL8 release and kappaB-luciferase activity were inhibited by the Shc small interfering RNA (siRNA), p66Shc siRNA, GW 5074 (a Raf-1 inhibitor), and PD98059 (a mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitor).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	184-191	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
23425072-0	2013	Acidic deoxycholic acid and chenodeoxycholic acid induce interleukin-8 production through p38 mitogen-activated protein kinase and protein kinase A in a squamous epithelial model.	Deoxycholic Acid	7-23	C-X-C motif chemokine ligand 8	Homo sapiens	57-70
23186593-5	2013	The levels of IL-6, IL-8 and ICAM were significantly lower in the GL group.	gl	66-68	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
23554253-4	2013	Whereas the reactive oxygen species production and IL-6 secretion were similar following a 24-h treatment with either MC, 100 microM MC-LR induced a five-fold greater IL-8 secretion when compared to MC-RR.	cyanoginosin LR	133-138	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
22995323-8	2013	In subjects receiving SB-656933 50mg, sputum neutrophils and elastase were reduced compared to baseline (probability of a true reduction, 0.889 and 0.882 respectively), and free DNA reduced compared to placebo (probability of a true reduction, 0.967), while blood levels of fibrinogen, CRP and CXCL8 were increased.	SB 656933	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	294-299
23525265-8	2013	The PCN (100 mumol/L) significantly increased the production of interleukin-8 (IL-8), prostaglandin E2 (PGE2), and leukotriene B4 (LTB4) in both cell lines.	Pyocyanine	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	64-77
23525265-8	2013	The PCN (100 mumol/L) significantly increased the production of interleukin-8 (IL-8), prostaglandin E2 (PGE2), and leukotriene B4 (LTB4) in both cell lines.	Pyocyanine	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
23525265-9	2013	Consistent with its paradoxical role in modulating PCN-induced toxicity, 3-MA (5 mmol/L) significantly reduced the PCN-induced production of IL-8, PGE2, and LTB4 in 1321N1 astrocytoma cells but augmented their production in SH-SY5Y neuroblastoma cells.	3-methyladenine	73-77	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
23525265-9	2013	Consistent with its paradoxical role in modulating PCN-induced toxicity, 3-MA (5 mmol/L) significantly reduced the PCN-induced production of IL-8, PGE2, and LTB4 in 1321N1 astrocytoma cells but augmented their production in SH-SY5Y neuroblastoma cells.	Pyocyanine	115-118	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
23525265-10	2013	In conclusion, we show here for the first time the paradoxical role of autophagy in mediating PCN-induced toxicity in 1321N1 astrocytoma and SH-SY5Y neuroblastoma cells and provide novel evidence that these actions may be mediated by effects on IL-8, PGE2, and LTB4 production.	Pyocyanine	94-97	C-X-C motif chemokine ligand 8	Homo sapiens	245-249
23611390-5	2013	METHODS: Endodontic files were dissolved in sodium fluoride (NaF) by passing a 50-mA current through the NiTi files while immersed in the NaF solution.	Sodium Fluoride	44-59	C-X-C motif chemokine ligand 8	Homo sapiens	61-64
23611390-9	2013	RESULTS: NaF solution reduced PDL cell survival, and the NaF/NiTi solution further reduced PDL cell survival.	nitinol	61-65	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
23425072-0	2013	Acidic deoxycholic acid and chenodeoxycholic acid induce interleukin-8 production through p38 mitogen-activated protein kinase and protein kinase A in a squamous epithelial model.	Chenodeoxycholic Acid	28-49	C-X-C motif chemokine ligand 8	Homo sapiens	57-70
23425072-2	2013	The effects of bile acids, which are major components of reflux fluid, on the production of IL-8 and related mechanisms remain unclear.	Bile Acids and Salts	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
23425072-5	2013	Bile acids under different pH conditions were added to the apical compartment to examine their effects on IL-8 production and the underlying cellular signaling.	Bile Acids and Salts	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
23425072-6	2013	RESULTS: Conjugated bile acids under a neutral or acidic condition did not induce IL-8 production, and unconjugated bile acids, deoxycholic acid (DCA), and chenodeoxycholic acid (CDCA) all significantly induced IL-8 production, dose- and time-dependently, only under weakly acid conditions.	Chenodeoxycholic Acid	156-177	C-X-C motif chemokine ligand 8	Homo sapiens	211-215
23425072-7	2013	Inhibition of p38 mitogen-activated protein kinase (p38 MAPK) and protein kinase A (PKA) attenuated the production of IL-8 induced by acidic DCA and CDCA.	Deoxycholic Acid	141-144	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
23425072-7	2013	Inhibition of p38 mitogen-activated protein kinase (p38 MAPK) and protein kinase A (PKA) attenuated the production of IL-8 induced by acidic DCA and CDCA.	Chenodeoxycholic Acid	149-153	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
23425072-9	2013	CONCLUSIONS: Compared with conjugated bile acids, the unconjugated bile acids DCA and CDCA are more likely to induce IL-8 production in vivo, especially under weakly acid conditions.	Bile Acids and Salts	67-77	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
23425072-9	2013	CONCLUSIONS: Compared with conjugated bile acids, the unconjugated bile acids DCA and CDCA are more likely to induce IL-8 production in vivo, especially under weakly acid conditions.	Deoxycholic Acid	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
23425072-9	2013	CONCLUSIONS: Compared with conjugated bile acids, the unconjugated bile acids DCA and CDCA are more likely to induce IL-8 production in vivo, especially under weakly acid conditions.	Chenodeoxycholic Acid	86-90	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
23386688-9	2013	Using pharmacological inhibition of NF-kappaB and inducible knockdown of NF-kappaB p65, we found that JSI-124-induced expression of IL-6, IL-8, and SOCS3 was significantly inhibited, showing an NF-kappaB-dependent mechanism.	jsi	102-105	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
23047422-5	2013	Morphine and methadone, but not fentanyl, at &gt;10(-5) M decreased all tested cytokines except IL-8.	Morphine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
23047422-5	2013	Morphine and methadone, but not fentanyl, at &gt;10(-5) M decreased all tested cytokines except IL-8.	Methadone	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
23488692-9	2013	Furthermore, NS-398 reduced the production of IL-6 and IL-8, thus indicating that IL-1beta/HMGB1 complexes modulate cytokine production in part through prostanoid synthesis.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	13-19	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
23384547-5	2013	METHODS: The effect of sodium fluoride (NaF) on glycolytic metabolism of cultured chondrocytes was confirmed by measurement of intracellular adenosine triphosphate (ATP) production.	Sodium Fluoride	23-38	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
23384547-5	2013	METHODS: The effect of sodium fluoride (NaF) on glycolytic metabolism of cultured chondrocytes was confirmed by measurement of intracellular adenosine triphosphate (ATP) production.	Adenosine Triphosphate	141-163	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
23384547-5	2013	METHODS: The effect of sodium fluoride (NaF) on glycolytic metabolism of cultured chondrocytes was confirmed by measurement of intracellular adenosine triphosphate (ATP) production.	Adenosine Triphosphate	165-168	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
23384547-8	2013	RESULTS: ATP production was dose-dependently decreased by NaF in the human chondrocytic cell line HCS-2/8.	Adenosine Triphosphate	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
23384547-12	2013	CONCLUSIONS: These findings suggest that decreased ATP production by NaF promotes hypertrophy-like changes via activation of phospho-Smad1/5/8 in the presence of lactate.	Adenosine Triphosphate	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
23384547-12	2013	CONCLUSIONS: These findings suggest that decreased ATP production by NaF promotes hypertrophy-like changes via activation of phospho-Smad1/5/8 in the presence of lactate.	Lactic Acid	162-169	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
23488692-9	2013	Furthermore, NS-398 reduced the production of IL-6 and IL-8, thus indicating that IL-1beta/HMGB1 complexes modulate cytokine production in part through prostanoid synthesis.	Prostaglandins	152-162	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
23613823-0	2013	Enterococcus faecalis inhibits superantigen toxic shock syndrome toxin-1-induced interleukin-8 from human vaginal epithelial cells through tetramic acids.	tetramic acid	139-153	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
23613823-7	2013	We further demonstrated that this organism secretes two tetramic acid compounds which appear responsible for inhibition of interleukin-8 production, as well as inhibition of T cell proliferation due to toxic shock syndrome toxin-1.	tetramic acid	56-69	C-X-C motif chemokine ligand 8	Homo sapiens	123-136
23454444-5	2013	KEY FINDINGS: alpha-Chaconine and solanidine significantly reduced interleukin-2 (IL-2) and interleukin-8 (IL-8) productions in Con A-induced Jurkat cells.	alpha-chaconine	14-29	C-X-C motif chemokine ligand 8	Homo sapiens	92-105
23454444-5	2013	KEY FINDINGS: alpha-Chaconine and solanidine significantly reduced interleukin-2 (IL-2) and interleukin-8 (IL-8) productions in Con A-induced Jurkat cells.	alpha-chaconine	14-29	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
23454444-5	2013	KEY FINDINGS: alpha-Chaconine and solanidine significantly reduced interleukin-2 (IL-2) and interleukin-8 (IL-8) productions in Con A-induced Jurkat cells.	solanidine	34-44	C-X-C motif chemokine ligand 8	Homo sapiens	92-105
23454444-5	2013	KEY FINDINGS: alpha-Chaconine and solanidine significantly reduced interleukin-2 (IL-2) and interleukin-8 (IL-8) productions in Con A-induced Jurkat cells.	solanidine	34-44	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
23616769-8	2013	EGCG inhibited interleukin (IL)-1beta, transforming growth factor beta, IL-8, and chemokine (C-C motif) ligand 2 (CCL2) release by stimulated FLS and/or THP-1 cells in a dose-dependent manner.	epigallocatechin gallate	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
23616769-11	2013	Furthermore, MbetaCD enhanced the inflammatory response to CPP crystals increasing IL-8 and CCL2 secretion which was inhibited by EGCG in a dose-dependent manner.	methyl-beta-cyclodextrin	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
23616769-11	2013	Furthermore, MbetaCD enhanced the inflammatory response to CPP crystals increasing IL-8 and CCL2 secretion which was inhibited by EGCG in a dose-dependent manner.	epigallocatechin gallate	130-134	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
23369216-6	2013	Interestingly, our microarray and proteomics analysis show that only phenanthroline induced high expression and secretion of another angiogenic cytokine, interleukin-8, suggesting that the mechanism of phenanthroline-induced hypoxia is distinct from DFO and hypoxia and involves the activation of other signaling pathways.	Phenanthrolines	69-83	C-X-C motif chemokine ligand 8	Homo sapiens	154-167
23449982-6	2013	Both the potential ligands and 6-OAU elicited chemotaxis of human polymorphonuclear leukocytes (PMNs) and macrophages and amplified LPS-stimulated production of the proinflammatory cytokine IL-8 from PMNs and TNFalpha from macrophages.	6-OAU	31-36	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
23557437-8	2013	A release of pro-inflammatory markers TNF-alpha and IL-8 was neither observed upon Ag-NP and AgNO3 exposures as well as was not affected when cells were pre-stimulated with lipopolysaccharide (LPS).	Silver Nitrate	93-98	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
23557437-9	2013	Also, an induction of mRNA expression of TNF-alpha and IL-8, could only be observed for the highest AgNO3 concentration alone or even significantly increased when pre-stimulated with LPS after 4 h. However, this effect disappeared after 24 h. Furthermore, oxidative stress markers (HMOX-1, SOD-1) were expressed after 4 h in a concentration dependent manner following AgNO3 exposures only.	Silver Nitrate	100-105	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
23557437-9	2013	Also, an induction of mRNA expression of TNF-alpha and IL-8, could only be observed for the highest AgNO3 concentration alone or even significantly increased when pre-stimulated with LPS after 4 h. However, this effect disappeared after 24 h. Furthermore, oxidative stress markers (HMOX-1, SOD-1) were expressed after 4 h in a concentration dependent manner following AgNO3 exposures only.	Silver Nitrate	368-373	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
23481185-5	2013	RESULTS: Mono-methyl XAA analogues with substitutions at the seventh and eighth positions were the most active in stimulating human leukocytes to produce IL-6 and IL-8; and for inhibition of tube formation by ECV304 human endothelial-like cells, while 5- and 6-substituted analogues were the most active in murine cell systems.	mono-methyl xaa	9-24	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
23083515-0	2013	Vitamin D inhibits the expression of interleukin-8 in human periodontal ligament cells stimulated with Porphyromonas gingivalis.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
23083515-2	2013	The present study aimed to discover the effects of 1a,25-dihydroxyvitamin D3 (1,25D) on the expressions of interleukin (IL)-6 and IL-8 in human periodontal ligament cells (hPDLCs) stimulated with Porphyromonas gingivalis (P. gingivalis) W83.	Calcitriol	51-76	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
23083515-10	2013	CONCLUSION: Vitamin D may potentially inhibit the periodontal inflammation induced by P. gingivalis partly by decreasing the IL-8 expression in hPDLCs.	Vitamin D	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
23488631-3	2013	SI, AD, and DM reduced a mean phorbol-12-myristate-13-acetate/ionomycin (PMA/I)-stimulated release of the pro-inflammatory interleukins IL-6 and IL-8 by more than 50% (p &lt; 0.05).	ad	4-6	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
23488631-3	2013	SI, AD, and DM reduced a mean phorbol-12-myristate-13-acetate/ionomycin (PMA/I)-stimulated release of the pro-inflammatory interleukins IL-6 and IL-8 by more than 50% (p &lt; 0.05).	Tetradecanoylphorbol Acetate	30-61	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
23488631-3	2013	SI, AD, and DM reduced a mean phorbol-12-myristate-13-acetate/ionomycin (PMA/I)-stimulated release of the pro-inflammatory interleukins IL-6 and IL-8 by more than 50% (p &lt; 0.05).	Ionomycin	62-71	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
23488631-5	2013	A significant, more than 50% mean inhibition of PMA/I-induced IL-6 and IL-8 release was demonstrated for the volatile compounds 1,8-cineole, borneol, camphor, and thujone, but not for the nonvolatile rosmarinic acid when applied in concentrations representative of sage infusion.	Eucalyptol	128-139	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
23488631-5	2013	A significant, more than 50% mean inhibition of PMA/I-induced IL-6 and IL-8 release was demonstrated for the volatile compounds 1,8-cineole, borneol, camphor, and thujone, but not for the nonvolatile rosmarinic acid when applied in concentrations representative of sage infusion.	isoborneol	141-148	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
23488631-5	2013	A significant, more than 50% mean inhibition of PMA/I-induced IL-6 and IL-8 release was demonstrated for the volatile compounds 1,8-cineole, borneol, camphor, and thujone, but not for the nonvolatile rosmarinic acid when applied in concentrations representative of sage infusion.	Camphor	150-157	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
23488631-5	2013	A significant, more than 50% mean inhibition of PMA/I-induced IL-6 and IL-8 release was demonstrated for the volatile compounds 1,8-cineole, borneol, camphor, and thujone, but not for the nonvolatile rosmarinic acid when applied in concentrations representative of sage infusion.	beta-thujone	163-170	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
23488631-5	2013	A significant, more than 50% mean inhibition of PMA/I-induced IL-6 and IL-8 release was demonstrated for the volatile compounds 1,8-cineole, borneol, camphor, and thujone, but not for the nonvolatile rosmarinic acid when applied in concentrations representative of sage infusion.	rosmarinic acid	200-215	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
23472833-6	2013	We show that the salts when ordered by heat effects produced by mixing of NaF and NaBr with 3,3-, 6,9-, or 6,12-ionene fluorides and bromides follow the opposite ordering than in the case when the same alkali halide salts are mixed with more hydrophobic 12,12-ionene salts.	3,3-, 6,9-, or 6,12-ionene fluorides	92-128	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
23472833-6	2013	We show that the salts when ordered by heat effects produced by mixing of NaF and NaBr with 3,3-, 6,9-, or 6,12-ionene fluorides and bromides follow the opposite ordering than in the case when the same alkali halide salts are mixed with more hydrophobic 12,12-ionene salts.	Bromides	133-141	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
23472833-6	2013	We show that the salts when ordered by heat effects produced by mixing of NaF and NaBr with 3,3-, 6,9-, or 6,12-ionene fluorides and bromides follow the opposite ordering than in the case when the same alkali halide salts are mixed with more hydrophobic 12,12-ionene salts.	halide salts	209-221	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
23472833-6	2013	We show that the salts when ordered by heat effects produced by mixing of NaF and NaBr with 3,3-, 6,9-, or 6,12-ionene fluorides and bromides follow the opposite ordering than in the case when the same alkali halide salts are mixed with more hydrophobic 12,12-ionene salts.	12,12-ionene salts	254-272	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
23369216-6	2013	Interestingly, our microarray and proteomics analysis show that only phenanthroline induced high expression and secretion of another angiogenic cytokine, interleukin-8, suggesting that the mechanism of phenanthroline-induced hypoxia is distinct from DFO and hypoxia and involves the activation of other signaling pathways.	Phenanthrolines	202-216	C-X-C motif chemokine ligand 8	Homo sapiens	154-167
23369216-6	2013	Interestingly, our microarray and proteomics analysis show that only phenanthroline induced high expression and secretion of another angiogenic cytokine, interleukin-8, suggesting that the mechanism of phenanthroline-induced hypoxia is distinct from DFO and hypoxia and involves the activation of other signaling pathways.	dfo	250-253	C-X-C motif chemokine ligand 8	Homo sapiens	154-167
23295714-8	2013	RESULTS: Sevoflurane suppressed TNF-alpha-induced IL-6, IL-8, and MCP-1 gene expression and the production of IL-6 and IL-8 in SAEC under anoxia/reoxygenation conditions.	Sevoflurane	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
23086737-1	2013	The aims of this study were to assess the effects and potential mechanisms of parthenolide on the expression of vascular endothelial growth factor (VEGF), interleukin 8 (IL-8) and matrix metalloproteinase 9 (MMP-9) in human breast cancer cell line MDA-MB-231.	parthenolide	78-90	C-X-C motif chemokine ligand 8	Homo sapiens	155-168
23295714-8	2013	RESULTS: Sevoflurane suppressed TNF-alpha-induced IL-6, IL-8, and MCP-1 gene expression and the production of IL-6 and IL-8 in SAEC under anoxia/reoxygenation conditions.	Sevoflurane	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
23295714-12	2013	CONCLUSIONS: Sevoflurane suppressed the NF-kappaB-mediated production of pulmonary epithelial cell-derived inflammatory cytokines, including IL-6 and IL-8, which are capable of causing I/R injury.	Sevoflurane	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
23347208-6	2013	Our results showed that higher expression of interleukin-8 (IL-8) expression associated with 54.26 +- 34.46% of TAM infiltration of peritoneum was significantly higher than 16.58 +- 17.74% of CD3(+) T-cell by immunofluorescence co-staining and confocal microscopy.	tam	112-115	C-X-C motif chemokine ligand 8	Homo sapiens	45-58
23347208-6	2013	Our results showed that higher expression of interleukin-8 (IL-8) expression associated with 54.26 +- 34.46% of TAM infiltration of peritoneum was significantly higher than 16.58 +- 17.74% of CD3(+) T-cell by immunofluorescence co-staining and confocal microscopy.	tam	112-115	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
23347208-7	2013	THP-1 cells exhibited M2-polarized phenotype markers with high proportion of CD68(+) , CD206(+) and CD204(+) markers after phorbol 12-myristate 13-acetate (PMA) treatment, After co-culturing with TAM cells in a transwell chamber system, EOC cells (SKOV3) increased their IL-8 expression at the level of mRNA and protein.	Tetradecanoylphorbol Acetate	156-159	C-X-C motif chemokine ligand 8	Homo sapiens	271-275
23347208-9	2013	Furthermore, the upregulation of IL-8 expression in ovarian cancer cells induced by macrophages could be inhibited by pyrollidine dithiocarbamate, an inhibitor of nuclear factor (NF)- kappaB signal pathway.	pyrollidine dithiocarbamate	118-145	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
23525981-0	2013	Retraction note: Late phase activation of nuclear transcription factor kappaB by doxorubicin is mediated by interleukin-8 and induction of apoptosis via FasL.	Doxorubicin	81-92	C-X-C motif chemokine ligand 8	Homo sapiens	108-121
23086737-1	2013	The aims of this study were to assess the effects and potential mechanisms of parthenolide on the expression of vascular endothelial growth factor (VEGF), interleukin 8 (IL-8) and matrix metalloproteinase 9 (MMP-9) in human breast cancer cell line MDA-MB-231.	parthenolide	78-90	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
23086737-5	2013	The real-time PCR and Western blot data showed that the expressions of VEGF, IL-8 and MMP-9 were significantly inhibited by parthenolide at both transcription level and protein level in MDA-MB-231 cells.	parthenolide	124-136	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
23086737-8	2013	Hence, the expression of VEGF, IL-8 and MMP-9 may be suppressed by parthenolide through the inhibition of NF-kappaB DNA-binding activity in MDA-MB-231 cells.	parthenolide	67-79	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
23345392-0	2013	Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells.	sphingosine 1-phosphate	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	47-52
23498057-0	2013	Glutamine and alanine-induced differential expression of intracellular IL-6, IL-8, and TNF-alpha in LPS-stimulated monocytes in human whole-blood.	Glutamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
23498057-0	2013	Glutamine and alanine-induced differential expression of intracellular IL-6, IL-8, and TNF-alpha in LPS-stimulated monocytes in human whole-blood.	Alanine	14-21	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
23480345-7	2013	In particular, remifentanil decreased activation of intracellular signaling pathways, including p38 and ERK1/2, and expression of pro-inflammatory cytokines, including TNF-alpha, IL-6 and IL-8.	Remifentanil	15-27	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
22727544-8	2013	Taurolidine inhibited immunoglobulin (IL)-6, IL-8 and tumor necrosis factor-alpha expression in a dose dependent-fashion in both, pediatric oncology patients and healthy controls.	taurolidine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	45-81
23211566-10	2013	Unfractionated heparin significantly suppressed the TNF-alpha-induced and NF-kappaB-mediated secretion and expression of IL-8 and -6 as well as other molecules in decidualized and undifferentiated human ESCs.	Heparin	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	121-132
22107042-1	2013	When resorbable hydroxyapatite (HA) granules, which are used as a bone supplement material, were treated in neutral 4% sodium fluoride (NaF) solution, formation of a reactant resembling calcium fluoride was observed on the surface of the granules.	Durapatite	16-30	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
22107042-1	2013	When resorbable hydroxyapatite (HA) granules, which are used as a bone supplement material, were treated in neutral 4% sodium fluoride (NaF) solution, formation of a reactant resembling calcium fluoride was observed on the surface of the granules.	Durapatite	32-34	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
22107042-1	2013	When resorbable hydroxyapatite (HA) granules, which are used as a bone supplement material, were treated in neutral 4% sodium fluoride (NaF) solution, formation of a reactant resembling calcium fluoride was observed on the surface of the granules.	Sodium Fluoride	119-134	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
22107042-1	2013	When resorbable hydroxyapatite (HA) granules, which are used as a bone supplement material, were treated in neutral 4% sodium fluoride (NaF) solution, formation of a reactant resembling calcium fluoride was observed on the surface of the granules.	Calcium Fluoride	186-202	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
22107042-7	2013	The promotion of MG-63 cell migration and proliferation, as well as increased ALP activity, suggested that fluoride released from the surface of resorbable HA granules, which were fluoridated by prior treatment with neutral 4% NaF solution, can provide a superb method to supply fluoride and promote osteogenic cell differentiation.	Fluorides	107-115	C-X-C motif chemokine ligand 8	Homo sapiens	227-230
26105926-15	2013	IL-8 was inhibited up to 67% by the liposomal curcumin in human vaginal cell lines (End1/E6E7, Ect1/E6E7, VK2/E6E7) as compared to curcumin.	Curcumin	46-54	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
23276728-6	2013	CS inhibited NF-kappaB activation and the release of some of the key psoriatic cytokines such as TNFalpha, IL-8, IL-6 and CCL27.	Chondroitin Sulfates	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
24627774-10	2013	Conversely, pretreatment with anacardic acid inhibited IL-8 production and expression in A549 cells.	anacardic acid	30-44	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
23257347-8	2013	Compared to Placebo, treatment with Bimosiamose led to a decrease of the interleukin-8 concentration (-9.49 ng/mL, 95%CI -18.8 to -2.7 ng/mL, p = 0.008), for the neutrophil count a difference of -0.368 x 10(6) cells/mL (95%CI -1.256 to 0.407 x 10(6)/mL, p = 0.313) was found.	bimosiamose	36-47	C-X-C motif chemokine ligand 8	Homo sapiens	73-86
23434371-2	2013	However, here we show that Fas/CD95-induced apoptosis is associated with the production of an array of cytokines and chemokines, including IL-6, IL-8, CXCL1, MCP-1, and GMCSF.	ammonium ferrous sulfate	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
23434371-3	2013	Fas-induced production of MCP-1 and IL-8 promoted chemotaxis of phagocytes toward apoptotic cells, suggesting that these factors serve as "find-me" signals in this context.	ammonium ferrous sulfate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
23404123-9	2013	In B3 cells, the level of IL-8 increased significantly when the cells made direct contact with TA particles (1.33 times that of PBS, P &lt; 0.05, Student"s t-test), but not in noncontact cultures.	Triamcinolone Acetonide	95-97	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
23404123-9	2013	In B3 cells, the level of IL-8 increased significantly when the cells made direct contact with TA particles (1.33 times that of PBS, P &lt; 0.05, Student"s t-test), but not in noncontact cultures.	Lead	128-131	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
23433769-9	2013	Significant changes (defined a priori as p &lt; 0.1) in favour of AZD9668 were also seen in slow vital capacity, plasma interleukin-8, and post-waking sputum interleukin-6 and Regulated on Activation, Normal T-cell Expressed and Secreted levels.	N-((5-(methanesulfonyl)pyridin-2-yl)methyl)-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide	66-73	C-X-C motif chemokine ligand 8	Homo sapiens	120-133
23481492-10	2013	Carvedilol could also preserve cardiac contractility via modulation of the tumor necrosis factor alpha and interleukin 8 mRNA expression and reduction of Bcl-2 and cytochrome c protein production and decrease the occurrence of apoptosis ex vivo.	Carvedilol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	107-120
23859389-11	2013	CONCLUSION: Inhalation and intravenous infusion of ketamine before OLV are equally effective in lowering the serum levels of IL-6, IL-8 and sICAM-1.	Ketamine	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
24627774-0	2013	Anacardic acid, a histone acetyltransferase inhibitor, modulates LPS-induced IL-8 expression in a human alveolar epithelial cell line A549.	anacardic acid	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
24627774-9	2013	Pretreatment with TSA showed a dose-dependent stimulatory effect on IL-8 release from A549 cells as compared to LPS alone.	trichostatin A	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
23292117-9	2013	Additionally, 50 and 100 mumol/L of EGCG significantly reduced the secretion of VEGF and IL-8 proteins induced by HPV-16 E7 oncoprotein in NSCLC A549 cells.	epigallocatechin gallate	36-40	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
23356456-6	2013	Our analysis indicates that several BAL parameters, including neutrophil count, interleukin-8, alpha defensins and MMP-9, demonstrate highly replicable associations with BOS.	N-[4-(Aminosulfonyl)phenyl]-2-Mercaptobenzamide	170-173	C-X-C motif chemokine ligand 8	Homo sapiens	80-93
23292117-12	2013	CONCLUSIONS: EGCG inhibited HPV-16 oncoprotein-induced angiogenesis conferred by NSCLC through the inhibition of HIF-1alpha protein expression and HIF-1alpha-dependent expression of VEGF, IL-8, and CD31 as well as activation of Akt, suggesting that HIF-1alpha may be a potential target of EGCG against HPV-related NSCLC angiogenesis.	epigallocatechin gallate	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
23348104-1	2013	1-nitropyrene (1-NP), a common PAH in diesel exhaust, and its amine metabolite 1-aminopyrene (1-AP) induce distinctly different chemokine-responses in bronchial epithelial cells (BEAS-2B) characterized by increases in CXCL8 and CCL5, respectively.	1-nitropyrene	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	218-223
23466865-5	2013	Cyanidin, quercetin and PSPLE also significantly attenuated VCAM-1, IL-8 and CD40 expression, and quercetin significantly attenuated ICAM-1 and E-selectin expression (p &lt; 0.05).	cyanidin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
23466865-5	2013	Cyanidin, quercetin and PSPLE also significantly attenuated VCAM-1, IL-8 and CD40 expression, and quercetin significantly attenuated ICAM-1 and E-selectin expression (p &lt; 0.05).	psple	24-29	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
23388525-5	2013	The present study demonstrates that adenosine analog N-ethylcarboxyamidoadenosine (NECA) down-regulates TNF-alpha production and up-regulates IL-8 production by LPS-stimulated porcine monocytes.	Adenosine	36-45	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
23388525-5	2013	The present study demonstrates that adenosine analog N-ethylcarboxyamidoadenosine (NECA) down-regulates TNF-alpha production and up-regulates IL-8 production by LPS-stimulated porcine monocytes.	n-ethylcarboxyamidoadenosine	53-81	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
23388525-5	2013	The present study demonstrates that adenosine analog N-ethylcarboxyamidoadenosine (NECA) down-regulates TNF-alpha production and up-regulates IL-8 production by LPS-stimulated porcine monocytes.	Adenosine-5'-(N-ethylcarboxamide)	83-87	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
23397947-3	2013	In this study we investigated whether nicotinamide (NCT), the amide form of vitamin B3, might have a protective function in reducing the expression of interleukin (IL)-1beta, IL-6, IL-8, IL-10, monocyte chemoattractant protein (MCP)-1 and tumour necrosis factor (TNF)-alpha in UV-irradiated keratinocytes.	Niacinamide	38-50	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
23397947-3	2013	In this study we investigated whether nicotinamide (NCT), the amide form of vitamin B3, might have a protective function in reducing the expression of interleukin (IL)-1beta, IL-6, IL-8, IL-10, monocyte chemoattractant protein (MCP)-1 and tumour necrosis factor (TNF)-alpha in UV-irradiated keratinocytes.	Amides	45-50	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
23348104-1	2013	1-nitropyrene (1-NP), a common PAH in diesel exhaust, and its amine metabolite 1-aminopyrene (1-AP) induce distinctly different chemokine-responses in bronchial epithelial cells (BEAS-2B) characterized by increases in CXCL8 and CCL5, respectively.	1-nitropyrene	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	218-223
23348104-1	2013	1-nitropyrene (1-NP), a common PAH in diesel exhaust, and its amine metabolite 1-aminopyrene (1-AP) induce distinctly different chemokine-responses in bronchial epithelial cells (BEAS-2B) characterized by increases in CXCL8 and CCL5, respectively.	1-aminopyrene	79-92	C-X-C motif chemokine ligand 8	Homo sapiens	218-223
23348104-1	2013	1-nitropyrene (1-NP), a common PAH in diesel exhaust, and its amine metabolite 1-aminopyrene (1-AP) induce distinctly different chemokine-responses in bronchial epithelial cells (BEAS-2B) characterized by increases in CXCL8 and CCL5, respectively.	1-aminopyrene	94-98	C-X-C motif chemokine ligand 8	Homo sapiens	218-223
23422489-2	2013	In the present study, we investigated the effect of eugenol on interleukin-8 (IL-8) production by IL-1beta-stimulated oral cells.	Eugenol	52-59	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
23407636-7	2013	The Ang II type 1 receptor blocker (ARB) losartan significantly blocked Ang II-induced IL-8 production.	Losartan	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
23407636-8	2013	Notably, losartan blocked LPS-induced IL-8 production by THP-1 monocytes and produced a small but statistically significant reduction of baseline IL-8 production of naive THP-1 cells.	Losartan	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
23407636-8	2013	Notably, losartan blocked LPS-induced IL-8 production by THP-1 monocytes and produced a small but statistically significant reduction of baseline IL-8 production of naive THP-1 cells.	Losartan	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
23407636-9	2013	Losartan also produced a statistically significant increase of fluorescence intensity of naive CXCR1- and CXCR2-positive THP-1 monocytes, probably as a negative feedback effect secondary to IL-8 downregulation.	Losartan	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
23407636-12	2013	Moreover, losartan suppressed the IL-8 production of naive THP-1 monocytes and LPS-treated THP-1 monocytes, suggesting a broader spectrum of pleiotropic effects.	Losartan	10-18	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
23600327-5	2013	The constitutive expression of RANKL and Ki-67 and the production of IL-6 and IL-8 were significantly inhibited by Dex treatment.	Dexamethasone	115-118	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
23600327-6	2013	Further, Dex significantly suppressed the stimulatory effects of LPS on RANKL and Ki-67 expression and on IL-6 and IL-8 production.	Dexamethasone	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
23608554-9	2013	Additionally, significantly higher levels of IL-6 and IL-8 were observed in hydroxyurea-treated and untreated patients than in controls respectively (P = 0.04 and P = 0.01).	Hydroxyurea	76-87	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
23221335-0	2013	IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism.	Cyclic AMP	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
23422489-2	2013	In the present study, we investigated the effect of eugenol on interleukin-8 (IL-8) production by IL-1beta-stimulated oral cells.	Eugenol	52-59	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
23422489-8	2013	Eugenol (5-500 muM) significantly stimulated IL-8 production in HGF cells, but had bi-modal effects on HPCs, causing slight stimulation at lower concentration (5 muM) and a significant inhibition at higher concentration (500 muM), regardless of the presence or absence of serum.	Eugenol	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
23391723-7	2013	The TGF-beta type I receptor kinase inhibitor LY2157299, a neutralizing TGF-beta type II receptor antibody, and SMAD4 siRNA all blocked paclitaxel-induced IL8 transcription and CSC expansion.	Paclitaxel	136-146	C-X-C motif chemokine ligand 8	Homo sapiens	155-158
23246486-3	2013	PGE2 stimulation increased SDF-1 expression in the prostate stromal cell lines WPMY-1 and NAF.	Dinoprostone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
23246486-10	2013	We also demonstrate stimulation of migration of prostate cancer cell lines PC3 and DU145 with conditioned media collected from WPMY-1 or NAF cells stimulated with PGE2 and blockade of enhanced migration by a SDF-1 neutralizing antibody.	Dinoprostone	163-167	C-X-C motif chemokine ligand 8	Homo sapiens	137-140
23507231-7	2013	Phosphatidylserine inhibited the production of inflammatory mediators IL-6; IL-8; vascular endothelial growth factor; and, in particular, prostaglandin E(2) in IL-1beta-stimulated RA-FLS.	Phosphatidylserines	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
23391723-7	2013	The TGF-beta type I receptor kinase inhibitor LY2157299, a neutralizing TGF-beta type II receptor antibody, and SMAD4 siRNA all blocked paclitaxel-induced IL8 transcription and CSC expansion.	LY-2157299	46-55	C-X-C motif chemokine ligand 8	Homo sapiens	155-158
23168489-5	2013	As well, we found that repeated exposures of the cells to HCHO and NO2 at concentrations that can be found indoors triggered a significant decrease in cell metabolism and an increase in IL-8 release that were not evoked by a single exposure.	Nitrogen Dioxide	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
23333790-10	2013	NQ up-regulated Il-8, Tnf, and Mcp-1 genes, while AQ induced the expression of Rantes gene.	nq	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
23446563-9	2013	RESULTS: Hydrogen sulfide treatment significantly increased L-selectin shedding from human neutrophils following activation by fMLP and interleukin-8 in an ADAM-17-dependent manner.	Hydrogen Sulfide	9-25	C-X-C motif chemokine ligand 8	Homo sapiens	136-149
23348005-9	2013	Quercetin (10 muM) decreased TNF-alpha and IL-8 by 59.74% and 41.11% respectively and inhibited generation of lipid peroxides by 50.5%.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
23321310-0	2013	The depletion of interleukin-8 causes cell cycle arrest and increases the efficacy of docetaxel in breast cancer cells.	Docetaxel	86-95	C-X-C motif chemokine ligand 8	Homo sapiens	17-30
23498787-7	2013	RESULTS: Fenoldopam preconditioning significantly decreased the serum concentrations of sCR, BUN, IL-8, and TNF-alpha in recipients.	Fenoldopam	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
23439564-3	2013	PHF, DP and GA could significantly suppress the expression of allergic inflammatory cytokine IL-33-upregulated intercellular adhesion molecule (ICAM)-1, and the release of chemokines CCL2, CCL5, CXCL8 and inflammatory cytokine IL-6 from KU812 cells (all p &lt; 0.05).	phf	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	195-200
23439564-3	2013	PHF, DP and GA could significantly suppress the expression of allergic inflammatory cytokine IL-33-upregulated intercellular adhesion molecule (ICAM)-1, and the release of chemokines CCL2, CCL5, CXCL8 and inflammatory cytokine IL-6 from KU812 cells (all p &lt; 0.05).	dp	5-7	C-X-C motif chemokine ligand 8	Homo sapiens	195-200
23439564-3	2013	PHF, DP and GA could significantly suppress the expression of allergic inflammatory cytokine IL-33-upregulated intercellular adhesion molecule (ICAM)-1, and the release of chemokines CCL2, CCL5, CXCL8 and inflammatory cytokine IL-6 from KU812 cells (all p &lt; 0.05).	Gallic Acid	12-14	C-X-C motif chemokine ligand 8	Homo sapiens	195-200
23300006-7	2013	Ethanol also induced expression of endothelial VCAM-1 and ICAM-1, production of sICAM-1 and CXCL8, and the chemokine receptors CXCR3 and CXCR4 on CD4 and CD8 lymphocytes.	Ethanol	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	92-97
23347248-6	2013	The greater sodium loadings in NaF and in NaI resulted from larger anion loadings in these systems.	Sodium	12-18	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
22452634-7	2013	The release of CXCL8 (human homolog of murine chemokine CXCL2) by human peripheral blood mononuclear cells (PBMCs) and Jurkat cells was also reduced by FK866, as well as by sirtuin (SIRT) inhibitors and SIRT6 silencing, implying a pivotal role for this NAD(+)-dependent deacetylase in the production of this chemokine.	N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide	152-157	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
22452634-7	2013	The release of CXCL8 (human homolog of murine chemokine CXCL2) by human peripheral blood mononuclear cells (PBMCs) and Jurkat cells was also reduced by FK866, as well as by sirtuin (SIRT) inhibitors and SIRT6 silencing, implying a pivotal role for this NAD(+)-dependent deacetylase in the production of this chemokine.	NAD	253-259	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
23333395-6	2013	IL-8 production was significantly induced in 1% O(2), with 5.5 mM glucose (p&lt;0.01).	Oxygen	48-52	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
23333395-6	2013	IL-8 production was significantly induced in 1% O(2), with 5.5 mM glucose (p&lt;0.01).	Glucose	66-73	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
23321310-5	2013	IL-8 depletion also increased the chemosensitivity to docetaxel.	Docetaxel	54-63	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
23321310-6	2013	These results indicate a role for IL-8 in promoting tumor cell survival and resistance to docetaxel and highlight the potential therapeutic significance of IL-8 depletion in ER-negative breast cancer patients.	Docetaxel	90-99	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
23325889-4	2013	Use of blocking Abs and degradative enzymes demonstrated that CXCL8-stimulated filopodia formation was mediated by CXCR1 and CXCR2, Duffy Ag/receptor for chemokines, heparan sulfate (HS), and syndecans.	Heparitin Sulfate	166-181	C-X-C motif chemokine ligand 8	Homo sapiens	62-67
23275341-7	2013	We confirmed in primary cultures of normal human bronchial epithelial cells that A(2)-isoprostane inhibited ozone-induced NF-kappaB activation and IL-8 regulation.	(2)-isoprostane	82-97	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
23399260-5	2013	Stimulation of IL-8 secretion by CBG40 and Zymosan was hence not due to their beta-glucan content.	cbg40	33-38	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
23399260-5	2013	Stimulation of IL-8 secretion by CBG40 and Zymosan was hence not due to their beta-glucan content.	Zymosan	43-50	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
23325889-4	2013	Use of blocking Abs and degradative enzymes demonstrated that CXCL8-stimulated filopodia formation was mediated by CXCR1 and CXCR2, Duffy Ag/receptor for chemokines, heparan sulfate (HS), and syndecans.	Heparitin Sulfate	183-185	C-X-C motif chemokine ligand 8	Homo sapiens	62-67
23325889-5	2013	HS was present on filopodial protrusions appearing as a meshwork on the cell surface, which colocalized with CXCL8, and this glycosaminoglycan was 2,6-O- and 3-O-sulfated.	Heparitin Sulfate	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	109-114
23325889-6	2013	Transmission electron microscopy revealed that CXCL8-stimulated filopodial and microvilli-like protrusions that interacted with leukocytes before transendothelial migration and removal of HS reduced this migration.	Heparitin Sulfate	188-190	C-X-C motif chemokine ligand 8	Homo sapiens	47-52
23187895-1	2013	Disodium tetrafluoroargentate(II) (Na(2)AgF(4)) has been synthesized by the thermal decomposition of NaAg(III)F(4) in the presence of NaF.	disodium tetrafluoroargentate	0-29	C-X-C motif chemokine ligand 8	Homo sapiens	134-137
24049660-11	2013	The significantly increased postchallenge concentrations of IL-2, IL-8, IL-12p70, IL-13, IL-18, IFN- gamma , TNF- alpha , and TGF- beta were released by peripheral blood cells after stimulation with PMA, as compared with both their prechallenge concentrations and with the PBS control values.	Tetradecanoylphorbol Acetate	199-202	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
23187895-1	2013	Disodium tetrafluoroargentate(II) (Na(2)AgF(4)) has been synthesized by the thermal decomposition of NaAg(III)F(4) in the presence of NaF.	na(2)agf	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	134-137
23149820-9	2013	Furthermore, lapatinib, which targets EGFR/HER2, inhibited the mammosphere-promoting effect of IL-8 in both HER2-positive and negative patient-derived cancers.	Lapatinib	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
23408639-8	2013	The anti-leukemic effects of darinaparsin correlated with inhibition of the alternative NF-kappaB pathway and production of the inflammatory cytokine IL-8.	darinaparsin	29-41	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
22924768-1	2013	BACKGROUND AND PURPOSE: Recent studies suggested a role for PGE(2)  in the expression of the chemokine IL-8.	Prostaglandins E	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
22924768-5	2013	KEY RESULTS: In HEK-EP(1)  and HEK-EP(1)  + EP(4)  but not HEK or HEK-EP(4)  cells, PGE(2)  activated the IL-8 promoter and induced IL-8 mRNA and protein synthesis.	Prostaglandins E	84-87	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
22924768-5	2013	KEY RESULTS: In HEK-EP(1)  and HEK-EP(1)  + EP(4)  but not HEK or HEK-EP(4)  cells, PGE(2)  activated the IL-8 promoter and induced IL-8 mRNA and protein synthesis.	Prostaglandins E	84-87	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
22924768-8	2013	In HEK-EP(1)  + EP(4)  cells, PGE(2) -mediated IL-8 promoter activation and IL-8 mRNA induction were blunted by inhibition of IkappaB kinase.	Dinoprostone	30-36	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
22924768-12	2013	CONCLUSIONS AND IMPLICATIONS: These findings suggest that PGE(2) -mediated NF-kappaB activation by simultaneous stimulation of EP(1)  and EP(4)  receptors induces maximal IL-8 promoter activation and IL-8 mRNA and protein induction.	Dinoprostone	58-64	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
22924768-12	2013	CONCLUSIONS AND IMPLICATIONS: These findings suggest that PGE(2) -mediated NF-kappaB activation by simultaneous stimulation of EP(1)  and EP(4)  receptors induces maximal IL-8 promoter activation and IL-8 mRNA and protein induction.	Dinoprostone	58-64	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
22653750-5	2013	Therefore, we compared the potency of 13 different glucan preparations to induce in vitro production of IL-1beta, IL-6, IL-8 and TNF-alpha in human, whole blood cultures.	Glucans	51-57	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
22749216-5	2013	Simultaneous treatment of cells with DNA and dsRNA analog poly(I:C) leads to inhibition of poly(I:C)-activated secretion of IL-6 and IL-8.	Poly I-C	58-66	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
22749216-5	2013	Simultaneous treatment of cells with DNA and dsRNA analog poly(I:C) leads to inhibition of poly(I:C)-activated secretion of IL-6 and IL-8.	Poly I-C	58-67	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
22788664-11	2013	Treatment with PDTC, TPCK or Bay117082 effectively antagonized LPS-induced IL-8 protein release.	3-(4-methylphenylsulfonyl)-2-propenenitrile	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
22788664-12	2013	Moreover, both the promoter activity and the LPS-induced release of IL-8 were diminished upon the administration of U0126 and SB203580, but not SP600125.	U 0126	116-121	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
22788664-12	2013	Moreover, both the promoter activity and the LPS-induced release of IL-8 were diminished upon the administration of U0126 and SB203580, but not SP600125.	SB 203580	126-134	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
22956122-4	2013	By reverse transcription-polymerase chain reaction and enzyme-linked immunoadsorbent assay, we demonstrated that resveratrol used in combination with polydatin was able to modulate interleukin (IL)-6, IL-8 and tumor necrosis factor-alpha gene expression.	Resveratrol	113-124	C-X-C motif chemokine ligand 8	Homo sapiens	201-237
22956122-4	2013	By reverse transcription-polymerase chain reaction and enzyme-linked immunoadsorbent assay, we demonstrated that resveratrol used in combination with polydatin was able to modulate interleukin (IL)-6, IL-8 and tumor necrosis factor-alpha gene expression.	polydatin	150-159	C-X-C motif chemokine ligand 8	Homo sapiens	201-237
23335378-10	2013	On the other hand, paricalcitol therapy reduced IL-8, IL-1beta, and TNF-alpha.	paricalcitol	19-31	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
23335378-11	2013	CONCLUSIONS: These results further support the beneficial effects of vitamin D treatment in hemodialysis patients, since it strongly affects PAF/thrombin activities, PAF-metabolism, and IL-8, IL-1beta and TNF-alpha circulating levels.	Vitamin D	69-78	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
23273744-7	2013	Hydrogen decreased the amount of IL-8 and TNF-alpha in serum, inhibited the activity of malondialdehyde and myeloperoxidase, and increased the activity of superoxide dismutase in the lung grafts from brain-dead donors.	Hydrogen	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
23142559-6	2013	Furthermore, TNF-alpha-induced CXCL8 secretion was (i) inhibited by the MR antagonist tiotropium and the M3R antagonist 4-DAMP and (ii) enhanced by the M1/M3R agonist pilocarpine and the cholinesterase inhibitor physostigmine.	4-diphenylacetoxy-1,1-dimethylpiperidinium	120-126	C-X-C motif chemokine ligand 8	Homo sapiens	31-36
23142559-6	2013	Furthermore, TNF-alpha-induced CXCL8 secretion was (i) inhibited by the MR antagonist tiotropium and the M3R antagonist 4-DAMP and (ii) enhanced by the M1/M3R agonist pilocarpine and the cholinesterase inhibitor physostigmine.	Pilocarpine	167-178	C-X-C motif chemokine ligand 8	Homo sapiens	31-36
23142559-6	2013	Furthermore, TNF-alpha-induced CXCL8 secretion was (i) inhibited by the MR antagonist tiotropium and the M3R antagonist 4-DAMP and (ii) enhanced by the M1/M3R agonist pilocarpine and the cholinesterase inhibitor physostigmine.	Tiotropium Bromide	86-96	C-X-C motif chemokine ligand 8	Homo sapiens	31-36
23142559-6	2013	Furthermore, TNF-alpha-induced CXCL8 secretion was (i) inhibited by the MR antagonist tiotropium and the M3R antagonist 4-DAMP and (ii) enhanced by the M1/M3R agonist pilocarpine and the cholinesterase inhibitor physostigmine.	Physostigmine	212-225	C-X-C motif chemokine ligand 8	Homo sapiens	31-36
23142559-7	2013	Taken as a whole, these results suggest that ACh release by A549 cells enhances TNF-alpha-induced CXCL8 secretion through activation of the M3R.	Acetylcholine	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	98-103
23142559-9	2013	Inhibition of these pathways with specific inhibitors abrogated the pilocarpine-induced CXCL8 release.	Pilocarpine	68-79	C-X-C motif chemokine ligand 8	Homo sapiens	88-93
23142559-10	2013	Our results suggest that the TNF-alpha-induced secretion of CXCL8 in A549 cells is regulated by the release of ACh, the latter"s binding to the M3R and the downstream activation of NF-kappaB and the ERK1/2 and p38 MAPK signaling pathways.	Acetylcholine	111-114	C-X-C motif chemokine ligand 8	Homo sapiens	60-65
23425281-10	2013	Hydrocortisone in combination with low-dose infliximab potentiated the suppressive effects on TNF-alpha, IL-1beta, IL-8, and macrophage inflammatory protein-1alpha synthesis.	Hydrocortisone	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
23266380-0	2013	Inhibitory effects of benzodiazepines on the adenosine A(2B) receptor mediated secretion of interleukin-8 in human mast cells.	Benzodiazepines	22-37	C-X-C motif chemokine ligand 8	Homo sapiens	92-105
23433213-0	2013	[Inductive effect of zinc oxide nanoparticles on interleukin 8 gene expression in human bronchial epithelial cells and its regulatory mechanism].	Zinc Oxide	21-31	C-X-C motif chemokine ligand 8	Homo sapiens	49-62
23433213-1	2013	OBJECTIVE: To clarify the effect of zinc oxide nanoparticles (ZnO-NPs) (30 nm in diameter) on the interleukin 8 (IL-8) gene expression in human bronchial epithelial cells (BEAS-2B) and its regulatory mechanism.	Zinc Oxide	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	98-111
23433213-1	2013	OBJECTIVE: To clarify the effect of zinc oxide nanoparticles (ZnO-NPs) (30 nm in diameter) on the interleukin 8 (IL-8) gene expression in human bronchial epithelial cells (BEAS-2B) and its regulatory mechanism.	Zinc Oxide	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
23433213-4	2013	RT-PCR and ELISA were used to measure the mRNA and protein expression levels of IL-8 in the BEAS-2B cells exposed to ZnO-NPs.	Zinc Oxide	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
23433213-5	2013	The IL-8 mRNA decay assay was used to determine the effect of ZnO-NPs on IL-8 mRNA stability.	Zinc Oxide	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
23433213-6	2013	RESULTS: Exposure to ZnO-NPs significantly increased the level of IL-8 mRNA in BEAS-2B cells and the level of IL-8 protein in supernatant medium.	Zinc Oxide	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
23433213-6	2013	RESULTS: Exposure to ZnO-NPs significantly increased the level of IL-8 mRNA in BEAS-2B cells and the level of IL-8 protein in supernatant medium.	Zinc Oxide	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
23433213-7	2013	The transcription inhibitor significantly reduced the mRNA expression of IL-8 induced by ZnO-NPs.	Zinc Oxide	89-92	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
23433213-8	2013	ZnO-NPs significantly delayed IL-8 mRNA degradation in the BEAS-2B cells that were pretreated with actinomycin D for terminating IL-8 mRNA synthesis.	Zinc Oxide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
23433213-8	2013	ZnO-NPs significantly delayed IL-8 mRNA degradation in the BEAS-2B cells that were pretreated with actinomycin D for terminating IL-8 mRNA synthesis.	Zinc Oxide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
23433213-8	2013	ZnO-NPs significantly delayed IL-8 mRNA degradation in the BEAS-2B cells that were pretreated with actinomycin D for terminating IL-8 mRNA synthesis.	Dactinomycin	99-112	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
23433213-8	2013	ZnO-NPs significantly delayed IL-8 mRNA degradation in the BEAS-2B cells that were pretreated with actinomycin D for terminating IL-8 mRNA synthesis.	Dactinomycin	99-112	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
23266380-11	2013	In conclusion, this is the first study showing an inhibitory action of benzodiazepines on adenosine A(2B) receptor mediated interleukin-8 production in human mast (HMC1) cells.	Benzodiazepines	71-86	C-X-C motif chemokine ligand 8	Homo sapiens	124-137
23484689-2	2013	The K562 cells were treated by NHE1 specific inhibitor cariporide, the angiogenesis factors after inhibition of NHE1 were screened by using protein chip, the IL-8 expression level after cariporide treatment was detected by real-time quantitative PCR; the K562 cells with stable interference of NHE1 were constructed, the IL-8 expression level after interference of NHE1 was detected by real-time quantitative PCR; the p38 phosphorylation level in K562 cells treated with cariporide was detected by Western blot.	cariporide	186-196	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
23484689-2	2013	The K562 cells were treated by NHE1 specific inhibitor cariporide, the angiogenesis factors after inhibition of NHE1 were screened by using protein chip, the IL-8 expression level after cariporide treatment was detected by real-time quantitative PCR; the K562 cells with stable interference of NHE1 were constructed, the IL-8 expression level after interference of NHE1 was detected by real-time quantitative PCR; the p38 phosphorylation level in K562 cells treated with cariporide was detected by Western blot.	cariporide	186-196	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
23484689-3	2013	After treatment of K562 cells with p38 inhibitor SB203580, the IL-8 expression level was decreased by real-time quantitative PCR.	SB 203580	49-57	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
23484689-4	2013	The results of protein chip showed that IL-8 expression decreased after cariporide treatment.	cariporide	72-82	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
23484689-7	2013	The down-regulation of IL-8 expression induced by cariporide treatment was partially restored after K562 cells were treated with p38 inhibitor SB203580.	cariporide	50-60	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
23484689-7	2013	The down-regulation of IL-8 expression induced by cariporide treatment was partially restored after K562 cells were treated with p38 inhibitor SB203580.	SB 203580	143-151	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
23219793-8	2013	A 5.5- and 2-fold increase in interleukin -8 and -1beta secretion, respectively was detected 24 h following doxorubicin treatment.	Doxorubicin	108-119	C-X-C motif chemokine ligand 8	Homo sapiens	30-55
23266380-3	2013	Therefore, we investigated the effects of benzodiazepines on adenosine A(2B) receptor mediated interleukin-8 production in human mast cell leukaemia (HMC1) cells by an enzyme linked immunosorbent assay.	Benzodiazepines	42-57	C-X-C motif chemokine ligand 8	Homo sapiens	95-108
23266380-4	2013	The adenosine analogue N-ethylcarboxamidoadenosine (NECA, 0.3-3 muM) increased interleukin-8 production about 5-fold above baseline.	Adenosine	4-13	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
23266380-4	2013	The adenosine analogue N-ethylcarboxamidoadenosine (NECA, 0.3-3 muM) increased interleukin-8 production about 5-fold above baseline.	Adenosine-5'-(N-ethylcarboxamide)	23-50	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
23266380-4	2013	The adenosine analogue N-ethylcarboxamidoadenosine (NECA, 0.3-3 muM) increased interleukin-8 production about 5-fold above baseline.	Adenosine-5'-(N-ethylcarboxamide)	52-56	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
23266380-8	2013	Diazepam attenuated the NECA-induced expression of mRNA encoding for interleukin-8.	Diazepam	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	69-82
23364629-17	2013	Both treatment with paricalcitol and with calcifediol produced a significant decrease in levels of IL-8 (P&lt;.001), a known inflammatory marker, drawing attention to a trend towards better response to erythropoiesis-stimulating agents (ESAs), possibly related to the decrease in inflammation.	paricalcitol	20-32	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
23339380-10	2013	HMG supplementation was able to reduce the catabolic genes" expression in cultured HACs such as matrix metalloproteinases (MMP1 &amp; MMP3), Interleukin 1, 6 and 8 (IL-1, IL-6 &amp; IL-8), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	Menotropins	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
23364629-17	2013	Both treatment with paricalcitol and with calcifediol produced a significant decrease in levels of IL-8 (P&lt;.001), a known inflammatory marker, drawing attention to a trend towards better response to erythropoiesis-stimulating agents (ESAs), possibly related to the decrease in inflammation.	Calcifediol	42-53	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
23139215-6	2013	In the immature xenograft, PCM exposure significantly attenuated LPS and IL-1beta-induced IL-8 and IL-6 expression, decreased TLR2 mRNA and TLR4 mRNA, and increased mRNA levels of specific negative regulators of inflammation, SIGIRR and Tollip.	pcm	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
23129725-1	2013	Entrenched in current laboratory protocols for the measurement of plasma glucose is the false belief that sodium fluoride (NaF) is an effective inhibitor of glycolysis.	Glucose	73-80	C-X-C motif chemokine ligand 8	Homo sapiens	123-126
23610962-0	2013	Role of protein tyrosine kinase in the effect of IP6 on IL-8 secretion in intestinal epithelial cells.	Phytic Acid	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
23610962-3	2013	The aim of this study was to determine the role of protein tyrosine kinase (PTK) in secretion of IL-8, a central proinflammatory cytokine, by unstimulated and IL-1beta-stimulated intestinal epithelial cells Caco-2 treated with IP6 (1 and 2.5 mM).	Phytic Acid	227-230	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
23610962-5	2013	IP6 had suppressive effect on basal and IL-1beta-stimulated IL-8 secretion by cells.	Phytic Acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
23610962-6	2013	The effect of OV on IL-8 release by cells treated with IP6 was different under constitutive and stimulated conditions.	Phytic Acid	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
23610962-7	2013	Secretion of IL-8 was significantly down-regulated in cells with GEN and GEN plus IP6 treatment.	Phytic Acid	82-85	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
23610962-9	2013	The results suggest that physiological intestinal concentrations of IP6 may have an inhibitory effect on IL-8 secretion by Caco-2 cells and one of the mechanisms of its action is the inhibition of PTK signaling cascade.	Phytic Acid	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
22984986-5	2013	RESULTS: EC from all FRT compartments constitutively expressed NOD1, NOD2, RIG-1, and MDA5 with highest levels expressed by FT. Stimulation with poly(I:C) resulted in upregulation of NOD2, RIG-1, and MDA5 in all FRT compartments and correlated with increased secretion of IL-8, whereas estradiol treatment had no effects.	Poly I-C	145-153	C-X-C motif chemokine ligand 8	Homo sapiens	272-276
24378274-11	2013	A time- and dose-dependent upregulation of the expression of IL-6 and IL-8 mRNA was observed during the treatment at 3 and 24 h. In contrast, TNF-alpha mRNA expression was highly upregulated at 3 h after FFA exposure but returned to control values at 24 h. In conclusion, hepatocytes exposed in vitro for a short time to low FFA concentrations showed a significant upregulation of IL-6 and IL-8 to,and a rapid but transitory elevation of TNF-alpha.	Fatty Acids, Nonesterified	204-207	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
24378274-11	2013	A time- and dose-dependent upregulation of the expression of IL-6 and IL-8 mRNA was observed during the treatment at 3 and 24 h. In contrast, TNF-alpha mRNA expression was highly upregulated at 3 h after FFA exposure but returned to control values at 24 h. In conclusion, hepatocytes exposed in vitro for a short time to low FFA concentrations showed a significant upregulation of IL-6 and IL-8 to,and a rapid but transitory elevation of TNF-alpha.	Fatty Acids, Nonesterified	325-328	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
23127653-14	2013	Furthermore, magnolol suppressed LPS-induced IL-8 production in HEK293-mTLR4/MD-2 cells.	magnolol	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
24169708-4	2013	Corrosion behaviour of Ti metal, Ti-6Al-7Nb and Ti-6Al-4V alloys and constituent metals investigated in artificial saliva is significantly affected by the presence of fluoride ions (added as NaF), as proven by electrochemical methods.	Fluorides	167-175	C-X-C motif chemokine ligand 8	Homo sapiens	191-194
23121078-6	2013	RESULTS: The PDE4 inhibitor rolipram dose dependently inhibited the IL-8 secretion induced by CSE 5%.	Rolipram	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
23390570-12	2013	The order of potency for inhibition of interleukin-8 release from MONOs was IL-10 &gt;betamethasone &gt;dexamethasone and hydrocortisone.	Betamethasone	86-99	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
23390570-12	2013	The order of potency for inhibition of interleukin-8 release from MONOs was IL-10 &gt;betamethasone &gt;dexamethasone and hydrocortisone.	Dexamethasone	104-117	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
23390570-12	2013	The order of potency for inhibition of interleukin-8 release from MONOs was IL-10 &gt;betamethasone &gt;dexamethasone and hydrocortisone.	Hydrocortisone	122-136	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
23129725-1	2013	Entrenched in current laboratory protocols for the measurement of plasma glucose is the false belief that sodium fluoride (NaF) is an effective inhibitor of glycolysis.	Sodium Fluoride	106-121	C-X-C motif chemokine ligand 8	Homo sapiens	123-126
23129725-2	2013	The failure of NaF to properly control glycolysis decreases plasma glucose concentrations.	Glucose	67-74	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
23991411-6	2013	The active form, hCaMKP-N(1-559), showed Mn(2+) or Mg(2+)-dependent phosphatase activity with a strong preference for phospho-Thr residues and was severely inhibited by NaF, but not by okadaic acid, calyculin A, or 1-amino-8-naphthol-2,4-disulfonic acid, a specific inhibitor of CaMKP.	Okadaic Acid	185-197	C-X-C motif chemokine ligand 8	Homo sapiens	169-172
22931421-8	2013	AZT down-regulated the pro-proliferative genes encoding AKT1, MYC, STAT1, MAPK8, MAPK9, CCL-3, Bcl-3, and cyclin D2; pro-angiogenenic genes encoding VEGF and IL8; and genes involved in cell adhesion (ICAM1 and FN1) and the NF-kappaB pathway.	Zidovudine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	158-161
23991411-6	2013	The active form, hCaMKP-N(1-559), showed Mn(2+) or Mg(2+)-dependent phosphatase activity with a strong preference for phospho-Thr residues and was severely inhibited by NaF, but not by okadaic acid, calyculin A, or 1-amino-8-naphthol-2,4-disulfonic acid, a specific inhibitor of CaMKP.	calyculin A	199-210	C-X-C motif chemokine ligand 8	Homo sapiens	169-172
24236291-7	2013	After K562 target cell stimulation, PBMC produced profound proinflammatory and immunoregulatory cytokines/chemokines including IL-2, IL-8, IL-10, MIP-1 alpha beta , IFN- gamma , and TNF- alpha , and cytokine/chemokine secretion was related to flowcytometry-based NK cytotoxicity.	PBMC	36-40	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
23991411-6	2013	The active form, hCaMKP-N(1-559), showed Mn(2+) or Mg(2+)-dependent phosphatase activity with a strong preference for phospho-Thr residues and was severely inhibited by NaF, but not by okadaic acid, calyculin A, or 1-amino-8-naphthol-2,4-disulfonic acid, a specific inhibitor of CaMKP.	Chicago acid	215-253	C-X-C motif chemokine ligand 8	Homo sapiens	169-172
23295625-0	2013	Fluoride gastrointestinal absorption from Na2FPO3/CaCO3- and NaF/SiO2-based toothpastes.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	61-64
23242618-7	2013	The stromal IL-8 positivity was associated with shorter DFS and OS in ER positive group, HER-2 negative group, and luminal A group (P &lt; 0.05).	aspartyl-phenylalanine	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
23242618-7	2013	The stromal IL-8 positivity was associated with shorter DFS and OS in ER positive group, HER-2 negative group, and luminal A group (P &lt; 0.05).	Osmium	64-66	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
23710204-6	2013	Vitamin D3 acted in synergy with the TLR agonists LPS and peptidoglycan (PGN) in inducing IL-6, IL-8, and IL-10, whereas vitamin D3 completely inhibited LPS-induced secretion of IL-12.	Cholecalciferol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
23571769-2	2013	Fluoride at 300 mg/l (as NaF) inhibited dissolution of native HA by 12%, while potassium and sodium dodecyl phosphates (PDP, SDP), at 0.1% or higher, inhibited dissolution by 26-34%.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
23103705-7	2013	Among patients, male gender, LVEDVi, diuretic treatment, NYHA class I, NT-proBNP and IL-8 levels were significant determinants of urine neopterin levels by bivariate analysis.	Neopterin	136-145	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
23903639-5	2013	Fluoride ion release from the adhesive linearly increased with higher NaF concentration.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	70-73
23430672-11	2013	In the DEDG, significant negative correlations were detected between the Schirmer test and IL-1beta, IL6, IL8, and vascular endothelial growth factor levels, and between the fluorescein breakup time with IL6 and IL8 levels.	Fluorescein	174-185	C-X-C motif chemokine ligand 8	Homo sapiens	212-215
24273918-11	2013	A positive correlation was found between serum level of IL-8 and each of GSH (r = -0.534 and p = 0.000), SOD (r = -0.295 and p = 0.021), CAT (r = -0.545 and p = 0.000), and Zn (r = 0.422 and p = 0.001) in all patient groups.	Glutathione	73-76	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
24273918-11	2013	A positive correlation was found between serum level of IL-8 and each of GSH (r = -0.534 and p = 0.000), SOD (r = -0.295 and p = 0.021), CAT (r = -0.545 and p = 0.000), and Zn (r = 0.422 and p = 0.001) in all patient groups.	Zinc	173-175	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
23210792-8	2013	By contrast, the stilbenes inhibited UV-connected inflammatory cytokines excluding IL-8, but they prevalently stimulated NFkappaB, EGFR nuclear translocation and the AhR-CYP pathway.	Stilbenes	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
24348681-8	2013	Isolated challenge of the keratinocytes with IL-1 beta as well as with glycine resulted in an upregulation of IL6 and IL8 mRNA expression and activation of NF kappa B pathway.	Glycine	71-78	C-X-C motif chemokine ligand 8	Homo sapiens	118-121
22954322-7	2013	Whereas the poly(I:C)-induced secretion of IL-6, IP-10, and RANTES was inhibited by both IKK-2 inhibitor and LY294002, that of IL-8 was blocked only by IKK-2 inhibitor.	Poly I-C	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
22954322-8	2013	CONCLUSIONS: The poly(I:C)-induced secretion of IL-6, IP-10, and RANTES from human corneal fibroblasts is mediated by both NF-kappaB and PI3K signaling pathways, whereas that of IL-8 is mediated by the NF-kappaB pathway.	Poly I-C	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
22610152-3	2013	Monocyte-expressed heat shock protein 72 (HSP72) and plasma thiobarbituric acid reactive substances (TBARS) were significantly attenuated in BICARB compared to PLAC (p = 0.04 and p = 0.039, respectively), however total anti-oxidant capacity, the ratio of oxidised to total glutathione, cortisol, interleukin 6 and interleukin 8 were not significantly induced by the exercise.	Sodium Bicarbonate	141-147	C-X-C motif chemokine ligand 8	Homo sapiens	314-327
24228938-5	2013	Enhanced cerussite dissolution in the presence of high salt (NaCl or NaF) concentrations leads to an increase in pyromorphite nucleation and growth rates.	Salts	55-59	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
23843863-9	2013	S-[6]-Gingerol attenuated IL1beta-induced inflammation and oxidative stress in HuH7 cells, as evidenced by decreasing mRNA levels of inflammatory factor IL6, IL8, and SAA1, suppression of ROS generation, and increasing mRNA levels of DHCR24.	gingerol	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	158-161
23843863-11	2013	Similar to the protective effects of S-[6]-gingerol, both NS-398 (a selective COX2 inhibitor) and PDTC (a selective NF kappa B inhibitor) suppressed mRNA levels of IL6, IL8, and SAA1.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	58-64	C-X-C motif chemokine ligand 8	Homo sapiens	169-172
23041326-1	2013	BACKGROUND &amp; AIMS: Interleukin (IL)-8 has an important role in initiating inflammation in humans, attracting immune cells such as neutrophils through their receptors CXCR1 and CXCR2.	Adenosine Monophosphate	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	23-41
23983782-6	2013	Results showed that the hyperglycemia-induced GAG alterations in the cell surface perlecan as well as in the ECM indeed upregulated the expressions of IL-6, IL-8, and MCP-1 and the activities of MMP-2 and MMP-9 and downregulated the expressions of TIMP-2.	Glycosaminoglycans	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
23795507-10	2013	However, the degree of ionic absorption within the brush is again ion specific n the order NaCl &gt; NaBr &gt; NaI &gt; NaF at 1 m salt concentration.	Sodium Chloride	91-95	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
23795507-10	2013	However, the degree of ionic absorption within the brush is again ion specific n the order NaCl &gt; NaBr &gt; NaI &gt; NaF at 1 m salt concentration.	sodium bromide	101-105	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
23795507-10	2013	However, the degree of ionic absorption within the brush is again ion specific n the order NaCl &gt; NaBr &gt; NaI &gt; NaF at 1 m salt concentration.	Sodium Iodide	111-114	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
23795507-10	2013	However, the degree of ionic absorption within the brush is again ion specific n the order NaCl &gt; NaBr &gt; NaI &gt; NaF at 1 m salt concentration.	Salts	131-135	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
23795509-5	2013	Its maximum, however, is shifted towards higher DOTAP concentrations in the row: NaF &lt; NaCl &lt; NaBr.	1,2-dioleoyloxy-3-(trimethylammonium)propane	48-53	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
23935691-0	2013	Modulation of the expression of the proinflammatory IL-8 gene in cystic fibrosis cells by extracts deriving from olive mill waste water.	Water	130-135	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
23935691-2	2013	Polyphenols rich extracts derived from waste water from olive mill, obtained by a molecular imprinting approach, have been investigated in order to discover compounds able to reduce IL-8 expression in human bronchial epithelial cells (IB3-1 cells), derived from a CF patient with a DeltaF508/W1282X mutant genotype and stimulated with TNF-alpha.	Polyphenols	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
23935691-5	2013	Utilizing TNF-alpha-treated IB3-1 cells as experimental model system, we demonstrated that apigenin and cyanidin chloride are able to modulate the expression of the NF-kappaB-regulated IL-8 gene, while oleuropein showed no effect in regulating the expression of the gene IL-8.	Apigenin	91-99	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
23935691-5	2013	Utilizing TNF-alpha-treated IB3-1 cells as experimental model system, we demonstrated that apigenin and cyanidin chloride are able to modulate the expression of the NF-kappaB-regulated IL-8 gene, while oleuropein showed no effect in regulating the expression of the gene IL-8.	Apigenin	91-99	C-X-C motif chemokine ligand 8	Homo sapiens	271-275
23935691-5	2013	Utilizing TNF-alpha-treated IB3-1 cells as experimental model system, we demonstrated that apigenin and cyanidin chloride are able to modulate the expression of the NF-kappaB-regulated IL-8 gene, while oleuropein showed no effect in regulating the expression of the gene IL-8.	cyanidin	104-121	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
23935691-5	2013	Utilizing TNF-alpha-treated IB3-1 cells as experimental model system, we demonstrated that apigenin and cyanidin chloride are able to modulate the expression of the NF-kappaB-regulated IL-8 gene, while oleuropein showed no effect in regulating the expression of the gene IL-8.	cyanidin	104-121	C-X-C motif chemokine ligand 8	Homo sapiens	271-275
23795509-5	2013	Its maximum, however, is shifted towards higher DOTAP concentrations in the row: NaF &lt; NaCl &lt; NaBr.	Sodium Chloride	90-94	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
23795509-5	2013	Its maximum, however, is shifted towards higher DOTAP concentrations in the row: NaF &lt; NaCl &lt; NaBr.	sodium bromide	100-104	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
23041326-8	2013	IL-8 was strongly up-regulated on systemic or local inflammatory stimulation, increasing mobilization of immature CD11b(+)Gr-1(+) myeloid cells (IMCs) with thioglycolate-induced peritonitis, DSS-induced colitis, and H. felis-induced gastritis.	Thioglycolates	156-169	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
23041326-8	2013	IL-8 was strongly up-regulated on systemic or local inflammatory stimulation, increasing mobilization of immature CD11b(+)Gr-1(+) myeloid cells (IMCs) with thioglycolate-induced peritonitis, DSS-induced colitis, and H. felis-induced gastritis.	dss	191-194	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
23711848-0	2013	Effect of formoterol on eosinophil trans-basement membrane migration induced by interleukin-8-stimulated neutrophils.	Formoterol Fumarate	10-20	C-X-C motif chemokine ligand 8	Homo sapiens	80-93
23711848-3	2013	In this study, we investigated whether formoterol modified the trans-basement membrane migration (TBM) of eosinophils stimulated with neutrophils and IL-8.	Formoterol Fumarate	39-49	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
23711858-3	2013	Here, we examined the effects of the glucocorticoid fluticasone propionate (FP) on the expression of the inflammatory chemokines CCL5, CXCL8 and CXCL10.	Fluticasone	52-74	C-X-C motif chemokine ligand 8	Homo sapiens	135-140
23711848-10	2013	RESULTS: A combination of neutrophils and IL-8 significantly induced the eosinophil TBM; formoterol alone had no effect.	eosinophil tbm	73-87	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
23159604-0	2013	A vitamin D3 analog augmented interleukin-8 production by human monocytic cells in response to various microbe-related synthetic ligands, especially NOD2 agonistic muramyldipeptide.	Cholecalciferol	2-12	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
23711848-11	2013	However, formoterol modestly but significantly attenuated the TBM of eosinophils stimulated with neutrophils and IL-8.	Formoterol Fumarate	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
24024768-9	2013	Only TRP significantly decreased serum levels of apolipoprotein B (apoB; -6%), interleukin-8 (IL-8; -11%) and monocyte chemotactic protein-1 (MCP-1; -19%).	Tryptophan	5-8	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
23781245-7	2013	The mean Knoop hardness number (KHN) of 5% NaF with fTCP was greater than that of 5% NaF alone while the control group had the lowest mean KHN.	4-Fluoro-1-(1-(2-thienyl)cyclohexyl)piperidine	52-56	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
24024768-9	2013	Only TRP significantly decreased serum levels of apolipoprotein B (apoB; -6%), interleukin-8 (IL-8; -11%) and monocyte chemotactic protein-1 (MCP-1; -19%).	Tryptophan	5-8	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
22841520-5	2013	RESULTS: Compared to placebo, metformin reduced monocyte release of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, monocyte chemoattractant protein-1 and interleukin-8, as well as decreased plasma C-reactive protein levels, which were accompanied by an improvement in insulin sensitivity.	Metformin	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	170-183
23197259-8	2013	YKL-40-induced IL-8 was found to further stimulate proliferation and migration of BSMCs, and the effects were inhibited after neutralizing IL-8.	bsmcs	82-87	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
23197259-8	2013	YKL-40-induced IL-8 was found to further stimulate proliferation and migration of BSMCs, and the effects were inhibited after neutralizing IL-8.	bsmcs	82-87	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
23197259-9	2013	Through investigating the interaction of airway epithelium and smooth muscle, our findings implicate that YKL-40 may be involved in the inflammation of asthma by induction of IL-8 from epithelium, subsequently contributing to BSMC proliferation and migration.	bsmc	226-230	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
23228258-9	2013	Levels of proinflammatory cytokines (eg, interleukin 6, interleukin 8, and matrix metalloproteinase-3 [MMP3]) were increased by CQ treatment.	camphorquinone	128-130	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
23365588-3	2013	For the first method, blood samples were collected in tubes containing sodium fluoride (NaF), a glycolysis inhibitor.	Sodium Fluoride	71-86	C-X-C motif chemokine ligand 8	Homo sapiens	88-91
23566357-12	2013	CONCLUSIONS: Changes in the pre- and post-treatment profiles of BDNF in CSF and blood, HGF in CSF and CXCL8 (IL-8) in serum, suggest that minocycline may have effects in the CNS by modulating the production of neurotrophic growth factors.	Minocycline	138-149	C-X-C motif chemokine ligand 8	Homo sapiens	102-107
23566357-12	2013	CONCLUSIONS: Changes in the pre- and post-treatment profiles of BDNF in CSF and blood, HGF in CSF and CXCL8 (IL-8) in serum, suggest that minocycline may have effects in the CNS by modulating the production of neurotrophic growth factors.	Minocycline	138-149	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
23533307-8	2013	rSAA also affected the production of compounds present in the tumor microenvironment that orchestrate tumor progression, such as IL-8, the production of reactive oxygen species (ROS) and nitric oxide (NO).	rsaa	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
22971992-11	2013	EGCG modulated markers of cell cycle (p27/KIP1), angiogenesis (CD31, VEGF, IL-6, IL-8, SEMA3F, and HIF1alpha), and metastasis (MMP2 and MMP7).	epigallocatechin gallate	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
23878839-15	2013	Enamel F uptake by NaF and NaF/MFP was significantly greater than MFP dentifrices (P &lt; 0.05 to P &lt; 0.001), with the area under the depth curve being 2.4 and 2.2 times greater, respectively.	enamel f	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
23182920-9	2013	Bilirubin increased basal production of IL-8 and IL-1beta, but downregulated LPS-induced generation of IL-8 and MIP-1beta.	Bilirubin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
23182920-9	2013	Bilirubin increased basal production of IL-8 and IL-1beta, but downregulated LPS-induced generation of IL-8 and MIP-1beta.	Bilirubin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
23924923-9	2013	HGF-induced expression of Ets-1 and IL-8 was increased more by GRP treatment and inhibited by pretreatment with an ERK 1/2 inhibitor (PD098059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	134-142	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
24030317-5	2013	RESULTS: Histamine upregulated IL-6 and IL-8 expression and IL-6 and IL-8 secretion in a dose-dependent manner in HCEC.	Histamine	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
24030317-5	2013	RESULTS: Histamine upregulated IL-6 and IL-8 expression and IL-6 and IL-8 secretion in a dose-dependent manner in HCEC.	Histamine	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
24030317-6	2013	Niflumic acid (NFA), an hCLCA blocker, reduced histamine-induced IL-6 and IL-8 expression.	Niflumic Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
24030317-6	2013	Niflumic acid (NFA), an hCLCA blocker, reduced histamine-induced IL-6 and IL-8 expression.	Niflumic Acid	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
24030317-6	2013	Niflumic acid (NFA), an hCLCA blocker, reduced histamine-induced IL-6 and IL-8 expression.	Histamine	47-56	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
24030317-7	2013	CONCLUSION: Histamine-induced IL-6 and IL-8 production could be attenuated by NFA, an hCLCA blocker.	Histamine	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
24018975-4	2013	We demonstrate that miR-200 inhibits angiogenesis through direct and indirect mechanisms by targeting interleukin-8 and CXCL1 secreted by the tumour endothelial and cancer cells.	mir-200	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	102-115
23887394-12	2013	15d-PGJ2 downregulated LPS-induced IL-8 and MCP-1 production.	15-deoxyprostaglandin J2	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
23878839-14	2013	Overall, the degree of remineralisation was as follows: NaF-silica-pyrophosphate dentifrices (1000 ppm F) averaged 41%; NaF/MFP-silica (1500/1000 ppm F) 38%; MFP/NaF-dicalcium phosphate (1000/450 ppm F) 30%; MFP dentifrices (1000 ppm F) ranged from 15 to 23%.	silica-pyrophosphate	60-80	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
23878839-14	2013	Overall, the degree of remineralisation was as follows: NaF-silica-pyrophosphate dentifrices (1000 ppm F) averaged 41%; NaF/MFP-silica (1500/1000 ppm F) 38%; MFP/NaF-dicalcium phosphate (1000/450 ppm F) 30%; MFP dentifrices (1000 ppm F) ranged from 15 to 23%.	Silicon Dioxide	60-66	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
24030317-7	2013	CONCLUSION: Histamine-induced IL-6 and IL-8 production could be attenuated by NFA, an hCLCA blocker.	Niflumic Acid	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
23878839-15	2013	Enamel F uptake by NaF and NaF/MFP was significantly greater than MFP dentifrices (P &lt; 0.05 to P &lt; 0.001), with the area under the depth curve being 2.4 and 2.2 times greater, respectively.	enamel f	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
24030317-1	2013	BACKGROUND/AIMS: Histamine remains the main mediator of allergic conjunctivitis and induces interleukin (IL)-6 and IL-8 production in human conjunctival epithelial cells (HCEC).	Histamine	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
24030317-2	2013	The purpose of the present study was to determine whether histamine induced IL-6 and IL-8 expression in HCEC, and to describe the relationship between human calcium-activated chloride channel (hCLCA) 1 activity and IL-6 and IL-8 expression.	Histamine	58-67	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
23573194-8	2013	Budesonide with Formoterol reduced IL-17A and RORgamma(t), while increased FOXP3 in cultured T-lymphocytes from mild-moderate asthma/persistent rhinitis, and reduced the IL-8 release mediated by IL-17A present in NW and Ss from mild-moderate asthma/persistent rhinitis in nasal and bronchial epithelial cells.	Budesonide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
23844276-6	2013	Arachidonic acid and saturated fatty acids (SFAs) both demonstrate an ability to increase pro-inflammatory IL-8 along with numerous other inflammatory factors including IL-6, TNF alpha , IL-1 beta , and CXCL1 for arachidonic acid and IGB2 and CTSS for SFA.	Arachidonic Acid	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
23844276-6	2013	Arachidonic acid and saturated fatty acids (SFAs) both demonstrate an ability to increase pro-inflammatory IL-8 along with numerous other inflammatory factors including IL-6, TNF alpha , IL-1 beta , and CXCL1 for arachidonic acid and IGB2 and CTSS for SFA.	Fatty Acids	21-42	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
23840918-7	2013	Luteolin and kaempferol significantly reduced LPS-induced secretion of proinflammatory cytokines (IL-6 and IL-8) and prostaglandins (PGE(2) and PGF(2alpha)) in fetal membranes, IL-1beta-induced COX-2 gene expression and prostaglandin production in myometrium, and IL-1beta-induced MMP-9 activity in amnion and myometrial cells.	kaempferol	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
23555637-4	2013	METHODS AND RESULTS: Confluent human umbilical vein endothelial cell (HUVECs ) treated with atorvastatin demonstrated significantly decreased lipopolysaccharide (LPS)-mediated IL-6 and IL-8 generation.	Atorvastatin	92-104	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
23573194-8	2013	Budesonide with Formoterol reduced IL-17A and RORgamma(t), while increased FOXP3 in cultured T-lymphocytes from mild-moderate asthma/persistent rhinitis, and reduced the IL-8 release mediated by IL-17A present in NW and Ss from mild-moderate asthma/persistent rhinitis in nasal and bronchial epithelial cells.	Formoterol Fumarate	16-26	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
23383243-8	2013	Incubation of PMNs with the tripeptide N-ac-PGP resulted in the release of CXCL8, MMP8 and MMP9.	tripeptide K-26	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	75-80
23527233-0	2013	Resveratrol induces long-lasting IL-8 expression and peculiar EGFR activation/distribution in human keratinocytes: mechanisms and implications for skin administration.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
23527233-7	2013	Resveratrol induced delayed, long-lasting and steadily growing IL-8 gene and protein over-expression as well as enhanced EGFR phosphorylation, both abrogated by the EGFR kinase inhibitor PD168393.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
23527233-7	2013	Resveratrol induced delayed, long-lasting and steadily growing IL-8 gene and protein over-expression as well as enhanced EGFR phosphorylation, both abrogated by the EGFR kinase inhibitor PD168393.	PD168393	187-195	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
23527233-12	2013	CONCLUSIONS/SIGNIFICANCE: Resveratrol synergized with TNFalpha in the induction of delayed, long-lasting IL-8 expression through sustained EGFR-ERK axis activation.	Resveratrol	26-37	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
23326479-8	2013	RESULTS: DON induced a pro-inflammatory response with a significant increase of expression of mRNA encoding for IL-8, IL-1alpha and IL-1beta, TNF-alpha in all used models.	deoxynivalenol	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
23308155-6	2013	RESULTS: The effusion size and effusion VEGF, IL-8 and PAI-1/tPA ratio were significantly higher in CPPE than in UPPE, and significantly higher in multi-loculated PPE than in non-locualted and uni-loculated PPE, respectively.	ppe	101-104	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
24459828-10	2013	Stimulation with PolyI:C, Pam3CSK4 and LPS also lead to considerable increase of NF-kBp65, while increased levels of inflammatory cytokines were observed for IL-8, TNF and IL-6 in cells treated with PMA and MeV.	Poly I-C	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
24204381-8	2013	These results suggest that 15d-PGJ2 suppresses activin-induced ActR and Smad expression, down-regulates IL-6 production, and up-regulates IL-8 production via suppression of NF- kappa B and MAPK signaling pathway in HepG2 cells.	15-deoxy-delta(12,14)-prostaglandin J2	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
23117134-6	2013	Caffeine decreased (P &lt; 0.05) both the number of total uterine PMNs and expression of IL-8 mRNA in the endometrium after AI.	Caffeine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
23117134-9	2013	In conclusion, the addition of caffeine to the thawing solution inhibited migration of uterine PMNs, probably by downregulating IL-8 mRNA expression in the endometrium.	Caffeine	31-39	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
23294717-10	2013	At 48 h after 10(-7); or 10(-6); mol/L DEX was added, IL-8 levels in the culture supernatants of the hypoxia groups were higher than those in the corresponding normoxia groups (P&lt;0.05).	Dexamethasone	39-42	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
22985912-5	2013	The secretion of proinflammatory products was strongly stimulated by sequential incubation of EC with iodixanol and TNFalpha (p&lt;0.00001 for all tested molecules, namely TNFalpha, IL-8, sVCAM-1, MCP-1, and IL-6).	iodixanol	102-111	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
22975265-11	2012	C3 and IL-8 transcript levels were increased in pemetrexed-treated Lo cells relative to Lo controls; DHFR transcript levels were decreased.	Pemetrexed	48-58	C-X-C motif chemokine ligand 8	Homo sapiens	7-11
23256107-5	2012	IL-8 serum levels were higher in the first (P&amp;lt;0.0001) and third (P=0.003) trimesters of pregnancy in SLE patients compared with controls, INF-gamma serum levels in the third trimester (P=0.009), and IL-10 serum levels in the first and third trimesters (P=0.055 and P&amp;lt;0.0001, respectively).	Adenosine Monophosphate	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
23259744-10	2012	In M10 cells, TMZ promoted NF-kappaB2/p52 generation and nuclear translocation and enhanced the secretion of IL-8 and MCP-1.	Temozolomide	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
23070150-9	2012	The IL-8 cytokine response was found to be significantly lower for the magnetite nanoparticles compared to TiO(2), while an enhancement of ROS was observed, which was further increased for the ATP-modified nanoparticles, implicating involvement of the ATP signalling pathway in the epithelium.	Adenosine Triphosphate	193-196	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
22975265-12	2012	In Lo cells, IL-8 and C3 protein concentrations were increased following pemetrexed treatment.	Pemetrexed	73-83	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
23263807-0	2012	Inhibitory effect on TNF-alpha-induced IL-8 secretion in HT-29 cell line by glyceroglycolipids from the leaves of Ficus microcarpa.	glyceroglycolipids	76-94	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
22944462-8	2012	Pretreatment with LDFL at 20, 10 or 1 ng/ml reduced HDFL-induced IL-8 production by 61%, 52% and 40%, respectively (p&lt;0.05).	ldfl	18-22	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
22551309-4	2012	We report here our conclusions based on data from past studies that seizures are associated with elevated interleukin-8 (IL-8) and that dapsone inhibits IL-8 release and function in several different clinical and experimental contexts.	Dapsone	136-143	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
23089469-4	2012	This study was to investigate the influence of therapeutic concentrations of prazosin (0.01 and 0.1muM) on cell proliferation and differential expressions of CCL2, CCL20, CXCL6, CXCL10, IL8 and IL6 genes related to inflammation and/or oxidative stress in human HCC cell lines.	Prazosin	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	186-189
23399841-4	2012	Suppressing ROCK with the Y27632 inhibitor suppressed IL-1-stimulated Caco-2 cell CXCL8/IL-8 and IEC-6 cell CCL2/MCP-1 secretion and mRNA levels.	Y 27632	26-32	C-X-C motif chemokine ligand 8	Homo sapiens	82-87
23399841-4	2012	Suppressing ROCK with the Y27632 inhibitor suppressed IL-1-stimulated Caco-2 cell CXCL8/IL-8 and IEC-6 cell CCL2/MCP-1 secretion and mRNA levels.	Y 27632	26-32	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
23154477-1	2012	A 46-year-old female patient with infiltrating ductal carcinoma had an F-fluoride PET which demonstrated uptake in multiple skeletal metastasis and several upper abdominal lesions corresponding to liver metastases on contrast enhanced CT. F-NaF uptake in soft tissue metastases are likely to be more frequently encountered with the increasing use of F-NaF PET/CT in oncology.	f-fluoride	71-81	C-X-C motif chemokine ligand 8	Homo sapiens	241-244
23154477-1	2012	A 46-year-old female patient with infiltrating ductal carcinoma had an F-fluoride PET which demonstrated uptake in multiple skeletal metastasis and several upper abdominal lesions corresponding to liver metastases on contrast enhanced CT. F-NaF uptake in soft tissue metastases are likely to be more frequently encountered with the increasing use of F-NaF PET/CT in oncology.	f-fluoride	71-81	C-X-C motif chemokine ligand 8	Homo sapiens	352-355
22885734-7	2012	RESULTS: The mRNA expressions of CCL3, CCL4, and CXCL8 were up-regulated by IL-1beta and down-regulated by tacrolimus.	Tacrolimus	107-117	C-X-C motif chemokine ligand 8	Homo sapiens	49-54
23397001-6	2012	However, all three different sizes of silica nanoparticles induced IL-8 production.	Silicon Dioxide	38-44	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
23397001-9	2012	Therefore, IL-8 production induced by silica nanoparticles may be dependent on other mechanisms rather than intracellular Ca(++) increase and ROS generation.	Silicon Dioxide	38-44	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
22990619-5	2012	Plasma TNF-alpha and IL-8 levels were significantly higher in long-term heroin-dependent patients than in healthy controls (p &lt; 0.001).	Heroin	72-78	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
22763784-7	2012	To investigate the anti-inflammatory potential of EGCG, we evaluated pro-inflammatory cytokine synthesis in IGF-I-differentiated SZ95 sebocytes and found that expression of IL-1, IL-6, and IL-8 was decreased.	epigallocatechin gallate	50-54	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
22990619-6	2012	Chronic heroin-use-induced TNF-alpha and IL-8 levels were significantly (p &lt; 0.05) attenuated in patients treated for 12 weeks with add-on dextromethorphan.	Heroin	8-14	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
22990619-6	2012	Chronic heroin-use-induced TNF-alpha and IL-8 levels were significantly (p &lt; 0.05) attenuated in patients treated for 12 weeks with add-on dextromethorphan.	Dextromethorphan	142-158	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
23046766-5	2012	The estimated 40% inhibitory concentration (IC(40)) of TEI-A00114 on interleukin (IL)-8 production induced by lipopolysaccharide and on IL-1beta in human whole blood cells in vitro were 9.8 x 10(-8) or 1.8 x 10(-9)M, respectively.	(2-hydroxy-2-methyl-cyclopentanone-5-ylidene)methyl-9,10-secopregna-5,7,10(19)-triene-1,3-diol	55-65	C-X-C motif chemokine ligand 8	Homo sapiens	69-87
23088987-1	2012	PURPOSE: We characterized and identified the uroepithelial P2 receptor responsible for adenosine triphosphate mediated release of the cytokines interleukin-8 and 6.	Adenosine Triphosphate	87-109	C-X-C motif chemokine ligand 8	Homo sapiens	144-163
23088987-9	2012	Signaling pathway experiments showed that interleukin-8 release involved phospholipase C and inositol trisphosphate mediated signaling, indicating a P2Y receptor subtype.	inositol 1,2,3-trisphosphate	93-115	C-X-C motif chemokine ligand 8	Homo sapiens	42-55
23088987-11	2012	Gene expression analysis of P2 receptors showed that strong expression of P2Y(2) receptor and subsequent knockdown of P2Y(2) receptor mRNA for 72 and 96 hours abrogated interleukin-8 and 6 release after purinergic stimulation with adenosine triphosphate-gamma-S.	adenosine triphosphate-gamma-s	231-261	C-X-C motif chemokine ligand 8	Homo sapiens	169-182
23086146-8	2012	Our previous nuclear magnetic resonance studies indicate that IL-8 binding to the N-terminal residues is mediated by the membrane, underscoring the importance of the phospholipid bilayer for physiological activity.	phospholipid bilayer	166-186	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
23132229-8	2012	Exogenous H(2)S inhibited the TNF-alpha-mediated upregulation of NO, IL-6 and IL-8 in a dose-dependent manner.	Hydrogen Sulfide	10-15	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
23327913-20	2012	The contents of IL-8 in supernatants of normal fibroblasts in 1.00-4.00 mmol/L oleic acid groups were markedly higher than those in BC and EC groups (F = 2.717, P &lt; 0.05 or P &lt; 0.01).	Oleic Acid	79-89	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
23327913-21	2012	The contents of IL-8 in supernatants of scar fibroblasts in 2.00 and 4.00 mmol/L oleic acid groups were significantly higher than those in BC and EC groups (F = 3.338, P &lt; 0.05).	Oleic Acid	81-91	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
23086953-7	2012	SIRT6 increases the nuclear levels of the Ca(2+)-dependent transcription factor, nuclear factor of activated T cells (NFAT), and cyclosporin A, a calcineurin inhibitor that reduces NFAT activity, reduces TNF and IL8 expression in SIRT6-overexpressing cells.	Cyclosporine	129-142	C-X-C motif chemokine ligand 8	Homo sapiens	212-215
22935637-6	2012	Either the selective bradykinin B(2) receptor antagonist HOE 140 or the selective bradykinin B(1) receptor antagonist Lys-(des-Arg(9), Leu(8))-bradykinin alone halved IL-8 release and the combination of both drugs suppressed this effect.	lys-(des-arg	118-130	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
23181472-8	2012	A differential secretion of CXCL8 and CCL2 was observed upon oligosaccharide co-cultivation with colorectal epithelial Caco-2 cells.	Oligosaccharides	61-76	C-X-C motif chemokine ligand 8	Homo sapiens	28-33
22983351-0	2012	Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells.	Acrolein	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
22983351-0	2012	Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells.	Acrolein	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	56-61
22983351-6	2012	Furthermore, pharmacological inhibition of p38 MAPK or MK2 strongly accelerated the decay of IL-8 mRNA levels upon stimulation with CSE or acrolein and subsequent blockade of mRNA neosynthesis with actinomycin D in pulmonary structural cells (HBSMCs and airways epithelial cells) as well as in human alveolar macrophages.	Acrolein	139-147	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
23041168-11	2012	In conclusions, it is suggested that IL-1beta, IL-6, IL-8 and TNF-alpha were associated with TCE-induced hypersensitivity dermatitis.	Trichloroethylene	93-96	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
23285690-10	2012	The findings of this study show that p38 MAPK could be one of the molecular targets for IP6 in the intestinal epithelial cells and that IP6 inhibitory effect on IL-8 secretion by Caco-2 cells could be mediated by its inhibition of p38 activity.	Phytic Acid	136-139	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
23184827-1	2012	Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes.	Amines	22-27	C-X-C motif chemokine ligand 8	Homo sapiens	199-212
23184827-1	2012	Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes.	Amines	22-27	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
23184827-1	2012	Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes.	Amines	22-27	C-X-C motif chemokine ligand 8	Homo sapiens	235-239
23285696-0	2012	The effect of phytic acid on the expression of NF-kappaB, IL-6 and IL-8 in IL-1beta-stimulated human colonic epithelial cells.	Phytic Acid	14-25	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
23184827-1	2012	Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes.	poly(lactide)	52-64	C-X-C motif chemokine ligand 8	Homo sapiens	199-212
23184827-1	2012	Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes.	poly(lactide)	52-64	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
23184827-1	2012	Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes.	poly(lactide)	52-64	C-X-C motif chemokine ligand 8	Homo sapiens	235-239
23184827-1	2012	Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes.	cplas	66-71	C-X-C motif chemokine ligand 8	Homo sapiens	199-212
23184827-1	2012	Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes.	cplas	66-71	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
23184827-1	2012	Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes.	cplas	66-71	C-X-C motif chemokine ligand 8	Homo sapiens	235-239
23285690-0	2012	Phytic acid down-regulates IL-8 secretion from colonic epithelial cells by influencing mitogen-activated protein kinase signaling pathway.	Phytic Acid	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
23285690-6	2012	Furthermore, the role of signaling pathways involving p38 MAP kinase in IP6-induced down-regulation of IL-8 secretion by unstimulated and IL-1beta-stimulated cells in the presence of p38 MAP kinase activator (anisomycin) and inhibitor (SB 203580) was evaluated.	Phytic Acid	72-75	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
23285690-9	2012	The similar level of p38alpha mRNA was found in untreated and treated with IP6 cells after 6 and 12 h. Incubation of Caco-2 cells with anisomycin resulted in upregulation of IL-8 secretion and their pretreatment with anisomycin prior to IP6 addition showed down-regulation of IL-8 secretion compared to cells treated with anisomycin alone.	Phytic Acid	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
23285690-9	2012	The similar level of p38alpha mRNA was found in untreated and treated with IP6 cells after 6 and 12 h. Incubation of Caco-2 cells with anisomycin resulted in upregulation of IL-8 secretion and their pretreatment with anisomycin prior to IP6 addition showed down-regulation of IL-8 secretion compared to cells treated with anisomycin alone.	Anisomycin	135-145	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
23285690-9	2012	The similar level of p38alpha mRNA was found in untreated and treated with IP6 cells after 6 and 12 h. Incubation of Caco-2 cells with anisomycin resulted in upregulation of IL-8 secretion and their pretreatment with anisomycin prior to IP6 addition showed down-regulation of IL-8 secretion compared to cells treated with anisomycin alone.	Anisomycin	135-145	C-X-C motif chemokine ligand 8	Homo sapiens	276-280
23184827-1	2012	Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes.	poly(lactide)	52-63	C-X-C motif chemokine ligand 8	Homo sapiens	199-212
23184827-1	2012	Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes.	poly(lactide)	52-63	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
23285696-7	2012	The aim of this study was to analyze the effect of IP6 on the expression of IL-6 and IL-8 as well as p50 and p65 subunits of NF-kappaB and its inhibitor IkappaBalpha in Caco-2 cells stimulated with IL-1beta.	Phytic Acid	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
23184827-1	2012	Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes.	poly(lactide)	52-63	C-X-C motif chemokine ligand 8	Homo sapiens	235-239
23184827-4	2012	It is found that the degradability and cytotoxicity of CPLAs, as well as the transfection efficiency of the CPLA-IL-8 siRNA nanoplexes, positively correlate with the amine mol% of CPLAs.	Amines	166-171	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
23285696-10	2012	Treatment of cells with IP6 resulted in a marked decrease in both IL-6 (at 3 and 6 h) and IL-8 expression (3 h).	Phytic Acid	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
23184827-4	2012	It is found that the degradability and cytotoxicity of CPLAs, as well as the transfection efficiency of the CPLA-IL-8 siRNA nanoplexes, positively correlate with the amine mol% of CPLAs.	cplas	180-185	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
23285696-11	2012	The results of these studies suggest that IP6 may exert immunoregulatory effects on intestinal epithelium by influencing transcriptional activity of genes encoding p50 subunit of NF-kappaB, its inhibitor IkappaBalpha and proinflammatory cytokines IL-6 and IL-8.	Phytic Acid	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	256-260
22580394-0	2012	Increase of toll-like receptor 4 but decrease of interleukin-8 mRNA expression among ischemic stroke patients under aspirin treatment.	Aspirin	116-123	C-X-C motif chemokine ligand 8	Homo sapiens	49-62
23038702-10	2012	There were significant correlations between CGRP and IL-6 changes (P = 0.011) and between DLQI and IL-8 changes (P = 0.026) in the curcumin group.	Curcumin	131-139	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
23038702-11	2012	In the curcumin group, changes in serum IL-8 concentrations were found as the significant predictor of DLQI scores (P = 0.026) but none of the independent variables could predict pruritus scores.	Curcumin	7-15	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
22729138-11	2012	CONCLUSION: The phIGFBP-1 test is a fast and easy test that can be used with Bishop score and IL-8 to reach an high positive predictive value in the prediction of the success of labour induction with prostaglandins.	Prostaglandins	200-214	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
22580394-8	2012	A reduction of IL-8 expression could result from the downregulatory effects of aspirin.	Aspirin	79-86	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
23051921-0	2012	PGE2 induces interleukin-8 derepression in human astrocytoma through coordinated DNA demethylation and histone hyperacetylation.	Dinoprostone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	13-26
23051921-1	2012	We have recently reported that in astrocytoma cells the expression of interleukin-8 (IL-8) is upregulated by prostaglandin E2 (PGE2).	Dinoprostone	109-125	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
23051921-1	2012	We have recently reported that in astrocytoma cells the expression of interleukin-8 (IL-8) is upregulated by prostaglandin E2 (PGE2).	Dinoprostone	109-125	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
23051921-1	2012	We have recently reported that in astrocytoma cells the expression of interleukin-8 (IL-8) is upregulated by prostaglandin E2 (PGE2).	Dinoprostone	127-131	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
23051921-1	2012	We have recently reported that in astrocytoma cells the expression of interleukin-8 (IL-8) is upregulated by prostaglandin E2 (PGE2).	Dinoprostone	127-131	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
23051921-3	2012	Here, we have investigated whether IL-8 activation by PGE2 involves changes in DNA methylation and/or histone modifications in 46 astrocytoma specimens, two astrocytoma cell lines and normal astrocytic cells.	Dinoprostone	54-58	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
23051921-4	2012	The DNA methylation status of the IL-8 promoter was analyzed by bisulphite sequencing and by methylation DNA immunoprecipitation analysis.	hydrogen sulfite	64-74	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
23051921-6	2012	IL-8 expression at promoter, mRNA and protein level was explored by transfection, real-time PCR and enzyme immunoassay experiments in cells untreated or treated with PGE2, 5-aza-2"-deoxycytidine (5-aza-dC) and HDAC inhibitors, alone or in combination.	Dinoprostone	166-170	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
23051921-6	2012	IL-8 expression at promoter, mRNA and protein level was explored by transfection, real-time PCR and enzyme immunoassay experiments in cells untreated or treated with PGE2, 5-aza-2"-deoxycytidine (5-aza-dC) and HDAC inhibitors, alone or in combination.	Decitabine	172-194	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
23051921-6	2012	IL-8 expression at promoter, mRNA and protein level was explored by transfection, real-time PCR and enzyme immunoassay experiments in cells untreated or treated with PGE2, 5-aza-2"-deoxycytidine (5-aza-dC) and HDAC inhibitors, alone or in combination.	Decitabine	196-204	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
23051921-8	2012	We observed that PGE2 induced IL-8 activation through: (1) demethylation of the single CpG site 5 located at position -83 within the binding region for CEBP-beta in the IL-8 promoter; (2) C/EBP-beta and p300 co-activator recruitment; (3) H3 acetylation enhancement and (4) reduction in DNMT1, DNMT3a, HDAC2 and HDAC3 association to CpG site 5 region.	Dinoprostone	17-21	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
23051921-8	2012	We observed that PGE2 induced IL-8 activation through: (1) demethylation of the single CpG site 5 located at position -83 within the binding region for CEBP-beta in the IL-8 promoter; (2) C/EBP-beta and p300 co-activator recruitment; (3) H3 acetylation enhancement and (4) reduction in DNMT1, DNMT3a, HDAC2 and HDAC3 association to CpG site 5 region.	Dinoprostone	17-21	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
23051921-9	2012	Treatment with 5-aza-dC or HDAC inhibitors of class I HDACs strengthened either basal or PGE2-mediated IL-8 expression.	Azacitidine	15-20	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
23051921-9	2012	Treatment with 5-aza-dC or HDAC inhibitors of class I HDACs strengthened either basal or PGE2-mediated IL-8 expression.	Dinoprostone	89-93	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
23051921-10	2012	These findings have elucidated an orchestrated mechanism triggered by PGE2 whereby concurrent association of site-specific demethylation and histone H3 hyperacetylation resulted in derepression of IL-8 gene expression in human astrocytoma.	Dinoprostone	70-74	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
22899568-6	2012	Both TG accumulation and IL-8 secretion were shown to be dependent on ceramide production by specific knock-down of NSM2.	Ceramides	70-78	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
22696056-0	2012	Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8.	Phenols	18-25	C-X-C motif chemokine ligand 8	Homo sapiens	117-120
22696056-9	2012	Co-treatment with XBP1 inhibitors reduced IL6 and IL8 production induced by phenols, while overexpression of XBP1 alone increased their expression.	Phenols	76-83	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
22946548-5	2012	In contrast, the pro-haptens eugenol, isoeugenol, and 2-aminophenol stimulated high levels of IL-8 release from neutrophils alone.	pro-haptens	17-28	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
23069909-5	2012	report the upregulation of IL-6 and IL-8 after the activation of the unfolded protein response (UPR) following exposure of melanocytes to phenols.	Phenols	138-145	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
22841897-0	2012	1alpha,25-Dihydroxyvitamin D(3) inhibits vascular cellular adhesion molecule-1 expression and interleukin-8 production in human coronary arterial endothelial cells.	Calcitriol	0-31	C-X-C motif chemokine ligand 8	Homo sapiens	94-107
22762504-4	2012	Applied alone, RV, UV and FICZ induced time- and dose-dependent activation of aryl hydrocarbon receptor (AhR) pathway followed by over-expression of Cyp1A1 (metabolic response), UV and RV induced IL-8 expression (inflammatory response), while RV enhanced also HEK proliferation revealed by MTT assay and (3)H-thymidine incorporation.	monooxyethylene trimethylolpropane tristearate	290-293	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
22762504-4	2012	Applied alone, RV, UV and FICZ induced time- and dose-dependent activation of aryl hydrocarbon receptor (AhR) pathway followed by over-expression of Cyp1A1 (metabolic response), UV and RV induced IL-8 expression (inflammatory response), while RV enhanced also HEK proliferation revealed by MTT assay and (3)H-thymidine incorporation.	Thymidine	309-318	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
22927481-9	2012	Chemotaxis of CD16(bright)/CD62L(dim) neutrophils to the end-target chemoattractant N-formylmethionine-leucine-phenylalanine was lower compared with that for the CD16(dim)/CD62L(bright) neutrophil subset, whereas chemotaxis to cell-derived chemoattractant CXCL8 was comparable.	N-Formylmethionine	84-102	C-X-C motif chemokine ligand 8	Homo sapiens	256-261
22927481-9	2012	Chemotaxis of CD16(bright)/CD62L(dim) neutrophils to the end-target chemoattractant N-formylmethionine-leucine-phenylalanine was lower compared with that for the CD16(dim)/CD62L(bright) neutrophil subset, whereas chemotaxis to cell-derived chemoattractant CXCL8 was comparable.	leucine-phenylalanine	103-124	C-X-C motif chemokine ligand 8	Homo sapiens	256-261
22946548-5	2012	In contrast, the pro-haptens eugenol, isoeugenol, and 2-aminophenol stimulated high levels of IL-8 release from neutrophils alone.	Eugenol	29-36	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
22946548-5	2012	In contrast, the pro-haptens eugenol, isoeugenol, and 2-aminophenol stimulated high levels of IL-8 release from neutrophils alone.	isoeugenol	38-48	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
22946548-5	2012	In contrast, the pro-haptens eugenol, isoeugenol, and 2-aminophenol stimulated high levels of IL-8 release from neutrophils alone.	2-aminophenol	54-67	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
22721959-8	2012	Treatment of the cells with PD98059 resulted in inhibition of IL-8 mRNA expression induced by the toxin and that with SB203580 led to a decrease in the stabilization of IL-8 mRNA.	SB 203580	118-126	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
22721959-7	2012	On the other hand, PD98059 and SB203580 suppressed the toxin-induced production of IL-8.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
22684779-0	2012	Polyphenon-60 displays a therapeutic effect on acne by suppression of TLR2 and IL-8 expression via down-regulating the ERK1/2 pathway.	polyphenon-60	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
22684779-7	2012	We found that polyphenon-60 reduced the levels of P. acnes-enhanced TLR2 and interleukin-8 (IL-8) in THP-1 cells, human monocyte cell line and human primary monocytes.	polyphenon	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
22684779-8	2012	Taken together, these data demonstrate that polyphenon-60 has a therapeutic effect on acne by suppressing inflammation, specifically by inhibiting TLR2 expression and IL-8 secretion via down-regulation of extracellular signal-regulated kinases 1/2 (ERK1/2) pathway and activator protein-1 (AP-1) pathway.	polyphenon-60	44-57	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
22721959-7	2012	On the other hand, PD98059 and SB203580 suppressed the toxin-induced production of IL-8.	SB 203580	31-39	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
22923236-6	2012	Neutralizing antibodies against IL-6 and IL-8 partially reversed the drug resistance of MCF-7/R to paclitaxel and doxorubicin, while a neutralizing antibody against MCP-1 had no significant effect.	Paclitaxel	99-109	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
22721959-8	2012	Treatment of the cells with PD98059 resulted in inhibition of IL-8 mRNA expression induced by the toxin and that with SB203580 led to a decrease in the stabilization of IL-8 mRNA.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	28-35	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
22528769-4	2012	c-Fos methylation levels, according to the bisulfite sequencing results, were decreased in 20, 40, and 80 mg/l NaF-treated groups against the control group.	hydrogen sulfite	43-52	C-X-C motif chemokine ligand 8	Homo sapiens	111-114
22923236-6	2012	Neutralizing antibodies against IL-6 and IL-8 partially reversed the drug resistance of MCF-7/R to paclitaxel and doxorubicin, while a neutralizing antibody against MCP-1 had no significant effect.	Doxorubicin	114-125	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
22622430-5	2012	However, melanoma SP cells were also resistant to temozolomide, which is not a substrate for ABC transporters, through IL-8 upregulation.	Temozolomide	50-62	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
23077414-1	2012	OBJECTIVE: The aim of this study was to examine the effect of temperature on fluoride uptake by enamel specimens from a 0.05% NaF-fluoridated mouthrinse (Oral-B Advantage; Oral-B Laboratories, Newbridge, UK).	Fluorides	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	126-129
23077414-6	2012	This effect was particularly noticeable at 43 C. CONCLUSIONS: The temperature of the NaF mouthrinse may easily and safely be increased beyond room temperature by placing a container of the NaF mouthrinse in a bowl of hot water, allowing greater fluoride penetration into the enamel from the mouthrinse when used at home as a routine prophylactic agent.	Fluorides	245-253	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
23077414-6	2012	This effect was particularly noticeable at 43 C. CONCLUSIONS: The temperature of the NaF mouthrinse may easily and safely be increased beyond room temperature by placing a container of the NaF mouthrinse in a bowl of hot water, allowing greater fluoride penetration into the enamel from the mouthrinse when used at home as a routine prophylactic agent.	Fluorides	245-253	C-X-C motif chemokine ligand 8	Homo sapiens	189-192
22762377-3	2012	While poly(I:C) induced IL-8 gene expression was solely inhibited by the NF-kappaB inhibitor III, MCP-1 gene induction was also blocked by PKA, p38 MAPK and JAK-STAT inhibitors.	Poly I-C	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
22762377-6	2012	These data are indicative for distinct signalling pathways in the poly(I:C)-induced gene expression of IL-8 and MCP-1 in HaCaT keratinocytes.	Poly I-C	66-75	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
22947346-6	2012	In patients with severe asthma, dexamethasone caused less suppression of CCL11 and CXCL8 release induced by TNF-alpha.	Dexamethasone	32-45	C-X-C motif chemokine ligand 8	Homo sapiens	83-88
22526597-8	2012	The decreased activation of RelA by calcitriol was confirmed by decreased release of RelA-inducible molecules, including IL-5, IL-6 and IL-8, by HBSMCs upon calcitriol treatment.	Calcitriol	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
22526597-8	2012	The decreased activation of RelA by calcitriol was confirmed by decreased release of RelA-inducible molecules, including IL-5, IL-6 and IL-8, by HBSMCs upon calcitriol treatment.	Calcitriol	157-167	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
22971921-6	2012	Notably, these cells are also resistant to temozolomide, which is not a substrate for ATP-Binding Cassette (ABC) transporters, in an interleukin (IL)-8-dependent manner.	Temozolomide	43-55	C-X-C motif chemokine ligand 8	Homo sapiens	133-151
22715179-11	2012	Severe vitamin D deficiency (total 25(OH)D &lt;25 nmol/L) was associated with higher baseline TNF, IL-6, and IL-8 irrespective of IRIS status.	Vitamin D	7-16	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
22441735-10	2012	H(2)O(2)-decreased NRF expression and -enhanced IL-8/CXCL8 production was augmented in COPD PBMCs.	Hydrogen Peroxide	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
22441735-10	2012	H(2)O(2)-decreased NRF expression and -enhanced IL-8/CXCL8 production was augmented in COPD PBMCs.	Hydrogen Peroxide	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	53-58
22888169-10	2012	MAIN FINDINGS: Using the human first trimester trophoblast cell line, HTR8, pravastatin significantly augmented, compared with no treatment, aPL-dependent secretion of interleukin (IL)-8 (P&lt; 0.05), IL-1beta (P&lt; 0.05) and soluble endoglin (P&lt; 0.01) but had no effect on aPL-induced up-regulation of vascular endothelial growth factor, placenta growth factor or growth-related oncogene alpha secretion.	Pravastatin	76-87	C-X-C motif chemokine ligand 8	Homo sapiens	168-186
22507555-6	2012	SIRT1 inhibition by sirtinol or Sirt1 siRNA reversed the effects of melatonin on H(2) O(2) -mediated induction of pro-inflammatory cytokines (NO, PGE(2) , TNF-alpha, IL-1beta, and IL-8) and the expression of iNOS, COX-2, and cartilage destruction molecules.	Melatonin	68-77	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
22837207-7	2012	Compared to wild-type virus, NiVDeltaC induced increased expression of interleukin 1 beta (IL-1beta), IL-8, CXCL2, CXCL3, CXCL6, CCL20, and beta interferon.	nivdeltac	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
22787116-10	2012	MG262 concentration-dependently inhibited basal and transforming growth factor-beta-induced collagen mRNA expression and interleukin (IL)-1beta-induced production of IL-6, IL-8, monocyte chemoattractant protein-1, regulated on activation normal T cell expressed and secreted, and granulocyte/macrophage colony-stimulating factor in both fibroblast types.	MG 262	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
23046936-7	2012	The mRNA and protein expressions of both IL-8 and IP-10  were elevated significantly by the co-stimulation of LPS and  0.1 mug/mL poly (I:C) compared with control group and simple LPS groups.	poly	130-134	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
22687715-6	2012	In addition, IL-8 and IL-6 levels were significantly higher in culture supernatants of A549 cells that were incubated with formaldehyde-fixed P. brasiliensis compared to cultures of cells that were infected with live yeasts.	Formaldehyde	123-135	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
22752429-8	2012	We also showed that PF-04880594 stimulates production of the inflammatory cytokine interleukin 8 in HL-60 cells, suggesting a possible mechanism for the skin flushing observed in dogs.	PF-04880594	20-31	C-X-C motif chemokine ligand 8	Homo sapiens	83-96
22690903-5	2012	Only lipopolysaccharide (LPS), poly(I:C), Pam3CSK4 and MALP-2 could induce the production of IL-6, IL-8 and MCP-1 by adipocytes.	Poly I	31-37	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
22690903-5	2012	Only lipopolysaccharide (LPS), poly(I:C), Pam3CSK4 and MALP-2 could induce the production of IL-6, IL-8 and MCP-1 by adipocytes.	Carbon	38-39	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
23046936-8	2012	(2) The mRNA and protein expressions of IL-8 and IP-10 increased under the challenge of different concentrations of poly(I:C) (0.001,  0.01,  0.1 mug/mL) in a concentration-dependent manner,  which showed no change after adding 10 mug/mL LPS.	poly	116-120	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
23046936-9	2012	(3) Dexamethasone (1 mumol/L) and SB203580 (20 mumol/L) significantly decreased both the mRNA and protein production of IL-8 and IP-10 induced by co-stimulation of 0.1 mug/mL poly (I:C) and 10 mug/mL LPS compared with the control group and control+DMSO group respectively (P&lt;0.01 and P&lt;0.05).	Dexamethasone	4-17	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
23046936-9	2012	(3) Dexamethasone (1 mumol/L) and SB203580 (20 mumol/L) significantly decreased both the mRNA and protein production of IL-8 and IP-10 induced by co-stimulation of 0.1 mug/mL poly (I:C) and 10 mug/mL LPS compared with the control group and control+DMSO group respectively (P&lt;0.01 and P&lt;0.05).	SB 203580	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
23046936-9	2012	(3) Dexamethasone (1 mumol/L) and SB203580 (20 mumol/L) significantly decreased both the mRNA and protein production of IL-8 and IP-10 induced by co-stimulation of 0.1 mug/mL poly (I:C) and 10 mug/mL LPS compared with the control group and control+DMSO group respectively (P&lt;0.01 and P&lt;0.05).	poly	175-179	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
23046936-9	2012	(3) Dexamethasone (1 mumol/L) and SB203580 (20 mumol/L) significantly decreased both the mRNA and protein production of IL-8 and IP-10 induced by co-stimulation of 0.1 mug/mL poly (I:C) and 10 mug/mL LPS compared with the control group and control+DMSO group respectively (P&lt;0.01 and P&lt;0.05).	Dimethyl Sulfoxide	248-252	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
23006534-9	2012	RESULTS: Incubation with LPS, LTA or TCS significantly increased TNF-alpha, IL-1beta, IL-6, IL-8, IFN-gamma and IL-2 in comparison to incubation with RPMI alone.	lipoteichoic acid	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
22902791-7	2012	Bronchoalveolar lavage CCSP and CCSP/interleukin 8 levels were low and decreasing early after transplantation in LTR who developed BOS (P=0.015).	N-[4-(Aminosulfonyl)phenyl]-2-Mercaptobenzamide	131-134	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
23006534-9	2012	RESULTS: Incubation with LPS, LTA or TCS significantly increased TNF-alpha, IL-1beta, IL-6, IL-8, IFN-gamma and IL-2 in comparison to incubation with RPMI alone.	Technetium	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
23158718-1	2012	OBJECTIVE: To evaluate the diagnostic values of (18)F-sodium fluoride ((18)F-NaF) positron emission tomography/computed tomography (PET/CT) imaging in the detection of bone metastases of lung cancer.	Sodium Fluoride	54-69	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
22451299-0	2012	Resveratrol and its synthetic derivatives exert opposite effects on mesothelial cell-dependent angiogenesis via modulating secretion of VEGF and IL-8/CXCL8.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
22843691-6	2012	The induced TRPA1 channels, which were intrinsically activated by endogenous hydrogen peroxide and Zn(2+), suppressed secretion of interleukin-6 and interleukin-8.	Hydrogen Peroxide	77-94	C-X-C motif chemokine ligand 8	Homo sapiens	149-162
22843691-6	2012	The induced TRPA1 channels, which were intrinsically activated by endogenous hydrogen peroxide and Zn(2+), suppressed secretion of interleukin-6 and interleukin-8.	Zinc	99-101	C-X-C motif chemokine ligand 8	Homo sapiens	149-162
22790593-3	2012	In addition, HCl causes release of IL-8 from the esophageal mucosa.	Hydrochloric Acid	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
22790593-6	2012	HCl upregulated mRNA and protein expression for the acid-sensing transient receptor potential cation channel, subfamily vanilloid member 1 (TRPV1), lyso-PAF AT, IL-8, eotaxin-1, -2, and -3, macrophage inflammatory protein-1alpha, and monocyte chemoattractant protein-1.	Hydrochloric Acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
22790593-8	2012	In HET-1A cells, the TRPV1 agonist capsaicin reproduced these findings for mRNA of the inflammatory mediators lyso-PAF AT, IL-8, and eotaxin-1.	Capsaicin	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
22451299-0	2012	Resveratrol and its synthetic derivatives exert opposite effects on mesothelial cell-dependent angiogenesis via modulating secretion of VEGF and IL-8/CXCL8.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	150-155
22451299-4	2012	This effect was associated with decreased secretion of VEGF and IL-8/CXCL8 by HPMCs treated with RVT, which confirmed the experiments with recombinant forms of these angiogenic agents.	Hypromellose Derivatives	78-83	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
22451299-4	2012	This effect was associated with decreased secretion of VEGF and IL-8/CXCL8 by HPMCs treated with RVT, which confirmed the experiments with recombinant forms of these angiogenic agents.	Hypromellose Derivatives	78-83	C-X-C motif chemokine ligand 8	Homo sapiens	69-74
22549761-11	2012	Mitochondrial dysfunction increased the chemotactic activity induced by cytokines, and ROS and NF-kappaB inhibitors decreased the production of IL-8.	Reactive Oxygen Species	87-90	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
22684025-5	2012	Among the four families of oxPS studied, only oxPS modified in the polar head with formation of a terminal hydroperoxyacetaldehyde upregulated the production of cytokines IL-8 and TNF-alpha by monocytes and DCs subsets (mDCs and CD14(-/low)CD16(+) DCs).	Hydroperoxyacetaldehyde	107-130	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
22971256-7	2012	The brackets in group 4 were bonded with Transbond Plus self-etching primer, and group 5 underwent treatment with a 2% sodium fluoride (NaF) gel, which was applied on the enamel surface for 4 minutes before etching.	Sodium Fluoride	119-134	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
22796581-8	2012	Simvastatin significantly reduced plasma troponin T, isoenzyme of creatine kinase, C-reaction protein, blood urea nitrogen , creatinine, interleukin-6, interleukin-8, and the requirement of inotropic postoperatively.	Simvastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	152-165
22925316-4	2012	The mechanism(s) of action of macrolides in the treatment of these diseases remains unexplained, but may be due to their antibacterial and/or anti-inflammatory actions, which include reductions in interleukin-8 production, neutrophil migration and/or function.	Macrolides	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	197-210
22542524-17	2012	crispatus K243 and K313 inhibited the IL-8 secretion triggered by S. braenderup H9812 by 32.8% and 47.0%, indicating that the two isolates could attenuate the pro-inflammatory signaling induced by S. braenderup H9812, and have the potential application in clinical practice to prevent diarrhea.	palladium chloride	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
22248218-2	2012	The purpose of this study is to determine whether there are subpopulations of peripheral neutrophils in patients with chronic periodontitis (CP) that generate different levels of intracellular ROS when primed with tumor necrosis factor-alpha (TNF-alpha) or the chemokine interleukin-8 (IL-8, CXCL8) compared to controls.	Reactive Oxygen Species	193-196	C-X-C motif chemokine ligand 8	Homo sapiens	286-290
22897577-6	2012	We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs.	Adenosine Triphosphate	66-91	C-X-C motif chemokine ligand 8	Homo sapiens	238-243
22897577-6	2012	We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs.	Adenosine Triphosphate	66-91	C-X-C motif chemokine ligand 8	Homo sapiens	245-258
22897577-6	2012	We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs.	Adenosine Triphosphate	93-96	C-X-C motif chemokine ligand 8	Homo sapiens	238-243
22897577-6	2012	We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs.	Adenosine Triphosphate	93-96	C-X-C motif chemokine ligand 8	Homo sapiens	245-258
22743248-7	2012	We demonstrated that treatment of A375 cells with IS in combination with paclitaxel resulted in a significant decrease in the production of IL-8 and VEGF, compared with paclitaxel alone.	Paclitaxel	73-83	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
22618201-6	2012	The p38 inhibitor SB203580 and the STAT1 inhibitor EGCG blocked CM-induced IL-8 production at both early and late time periods.	SB 203580	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
22618201-6	2012	The p38 inhibitor SB203580 and the STAT1 inhibitor EGCG blocked CM-induced IL-8 production at both early and late time periods.	epigallocatechin gallate	51-55	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
22618201-7	2012	The NF-kappaB inhibitors PDTC and BAY11-7082 were found to increase CM-stimulated IL-8 production in Caco-2 cells at 24 h. CONCLUSIONS: Our data suggest an effective strategy to reduce IL-8 production is to block p38 or STAT1 rather than NF-kappaB.	3-(4-methylphenylsulfonyl)-2-propenenitrile	34-44	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
22618201-7	2012	The NF-kappaB inhibitors PDTC and BAY11-7082 were found to increase CM-stimulated IL-8 production in Caco-2 cells at 24 h. CONCLUSIONS: Our data suggest an effective strategy to reduce IL-8 production is to block p38 or STAT1 rather than NF-kappaB.	3-(4-methylphenylsulfonyl)-2-propenenitrile	34-44	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
23023382-6	2012	RESULTS: BSO and NAC significantly decreased IL-6 and TNF-alpha levels at 14 days of differentiation, whereas, NAC decreased the levels of IL-8 at days 2 and 14 of differentiation.	nac	111-114	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
22105830-10	2012	In addition, linoleic acid but not oleic acid induced MSC to increase production of interleukin-8.	Linoleic Acid	13-26	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
22105830-10	2012	In addition, linoleic acid but not oleic acid induced MSC to increase production of interleukin-8.	Oleic Acid	16-26	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
22320379-5	2012	RESULTS: The findings show that interleukin concentrations (IL-6, IL-8, TNF-alpha) were significantly decreased between 0 and 72 hours (p &lt; 0.01) in the newborns exposed to initial oxygen concentration of 45% and significantly increased in the other group.	Oxygen	184-190	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
22897577-6	2012	We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs.	adenosine 5'-O-(3-thiotriphosphate)	102-138	C-X-C motif chemokine ligand 8	Homo sapiens	238-243
22897577-6	2012	We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs.	adenosine 5'-O-(3-thiotriphosphate)	102-138	C-X-C motif chemokine ligand 8	Homo sapiens	245-258
22897577-6	2012	We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs.	adenosine 5'-O-(3-thiotriphosphate)	140-149	C-X-C motif chemokine ligand 8	Homo sapiens	238-243
22897577-6	2012	We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs.	adenosine 5'-O-(3-thiotriphosphate)	140-149	C-X-C motif chemokine ligand 8	Homo sapiens	245-258
22897577-6	2012	We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs.	Adenosine Triphosphate	140-143	C-X-C motif chemokine ligand 8	Homo sapiens	238-243
22897577-6	2012	We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs.	Adenosine Triphosphate	140-143	C-X-C motif chemokine ligand 8	Homo sapiens	245-258
22897577-8	2012	We have now demonstrated that AFC dose-dependently inhibits ATP-, ATPgammaS- and TNFalpha-induced production of CXCL1, CXCL8 and CCL2 by a human dermal microvascular EC line (HMEC-1) in vitro under conditions that do not affect cell viability.	Adenosine Triphosphate	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	119-124
22897577-8	2012	We have now demonstrated that AFC dose-dependently inhibits ATP-, ATPgammaS- and TNFalpha-induced production of CXCL1, CXCL8 and CCL2 by a human dermal microvascular EC line (HMEC-1) in vitro under conditions that do not affect cell viability.	adenosine 5'-O-(3-thiotriphosphate)	66-75	C-X-C motif chemokine ligand 8	Homo sapiens	119-124
22710663-5	2012	We demonstrated that 4,8-SD significantly inhibited tumor             necrosis factor-alpha (TNF-alpha)- and lipopolysaccharide (LPS)-induced expression of             IL-8 and E-selectin in human endothelial cells in a dose-dependent manner.	4,8-sd	21-27	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
22248218-2	2012	The purpose of this study is to determine whether there are subpopulations of peripheral neutrophils in patients with chronic periodontitis (CP) that generate different levels of intracellular ROS when primed with tumor necrosis factor-alpha (TNF-alpha) or the chemokine interleukin-8 (IL-8, CXCL8) compared to controls.	Reactive Oxygen Species	193-196	C-X-C motif chemokine ligand 8	Homo sapiens	271-284
22248218-2	2012	The purpose of this study is to determine whether there are subpopulations of peripheral neutrophils in patients with chronic periodontitis (CP) that generate different levels of intracellular ROS when primed with tumor necrosis factor-alpha (TNF-alpha) or the chemokine interleukin-8 (IL-8, CXCL8) compared to controls.	Reactive Oxygen Species	193-196	C-X-C motif chemokine ligand 8	Homo sapiens	292-297
22751949-6	2012	A degradation product of thymidine was implicated             in the enhanced expression of IL-8.	Thymidine	25-34	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
22751949-8	2012	An antioxidant, N-acetylcysteine (NAC), attenuated             the generation of ROS and IL-8 mRNA expression in KB and Yumoto cells, and H2O2             increased IL-8 mRNA expression in Yumoto cells, suggesting that ROS generated             by TP caused the increased expression of IL-8 mRNA.	Acetylcysteine	16-32	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
22527530-6	2012	To avoid dilution effects, urinary levels of IL-6 and IL-8 were expressed as the ratio of cytokine to urinary creatinine (pg/mg).	Creatinine	110-120	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
22751949-8	2012	An antioxidant, N-acetylcysteine (NAC), attenuated             the generation of ROS and IL-8 mRNA expression in KB and Yumoto cells, and H2O2             increased IL-8 mRNA expression in Yumoto cells, suggesting that ROS generated             by TP caused the increased expression of IL-8 mRNA.	Acetylcysteine	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
22751949-8	2012	An antioxidant, N-acetylcysteine (NAC), attenuated             the generation of ROS and IL-8 mRNA expression in KB and Yumoto cells, and H2O2             increased IL-8 mRNA expression in Yumoto cells, suggesting that ROS generated             by TP caused the increased expression of IL-8 mRNA.	Acetylcysteine	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
22751949-8	2012	An antioxidant, N-acetylcysteine (NAC), attenuated             the generation of ROS and IL-8 mRNA expression in KB and Yumoto cells, and H2O2             increased IL-8 mRNA expression in Yumoto cells, suggesting that ROS generated             by TP caused the increased expression of IL-8 mRNA.	Acetylcysteine	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
22751949-8	2012	An antioxidant, N-acetylcysteine (NAC), attenuated             the generation of ROS and IL-8 mRNA expression in KB and Yumoto cells, and H2O2             increased IL-8 mRNA expression in Yumoto cells, suggesting that ROS generated             by TP caused the increased expression of IL-8 mRNA.	Hydrogen Peroxide	138-142	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
22751949-8	2012	An antioxidant, N-acetylcysteine (NAC), attenuated             the generation of ROS and IL-8 mRNA expression in KB and Yumoto cells, and H2O2             increased IL-8 mRNA expression in Yumoto cells, suggesting that ROS generated             by TP caused the increased expression of IL-8 mRNA.	Hydrogen Peroxide	138-142	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
22751949-10	2012	Our findings             suggest that thymidine-derived sugars enhanced ROS generation and consequently             increased IL-8 expression.	Sugars	56-62	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
23157890-6	2012	The median of levels of IL-8 among the unexposed controls was 207.34 pg/ml, which was significantly higher than that among the TCE-exposed workers (28.26 pg/ml, P &lt; 0.01).	Trichloroethylene	127-130	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
22525295-7	2012	The proliferation of EBf-H9 and murine L929 cells was inhibited by sodium fluoride (NaF) and formaldehyde (FA), and the cell cycle was arrested in different phases with the treatments.	Sodium Fluoride	67-82	C-X-C motif chemokine ligand 8	Homo sapiens	84-87
22909087-7	2012	The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1beta, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-alpha.	Dimethyl Sulfoxide	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
22909087-7	2012	The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1beta, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-alpha.	Curcumin	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
22909087-7	2012	The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1beta, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-alpha.	Dimethyl Sulfoxide	65-69	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
22867088-15	2012	In addition, pretreatment of HBEC with the antioxidant N-acetyl cysteine significantly inhibited DEP-induced ERK and Akt phosphorylation, and subsequent IL-8 and IL-1beta expression.	Acetylcysteine	55-72	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
21964883-8	2012	Finally, we evaluated the regulation pathways involved in LPA-induced IL-8 expression.	lysophosphatidic acid	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
22841385-7	2012	Exposure of mdDC to purified CarLA resulted in the increased production of the pro-inflammatory cytokines IL-6 and to a lesser extent of IL-8 and TNF-alpha, and a reduced production of the anti-inflammatory cytokine IL-1RA.	mddc	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
22891766-5	2012	In this novel mechanism, TWIST1-mediated IL8 transcription is induced through the TWIST1 carboxy-terminal WR (Trp-Arg) domain instead of the classic DNA binding bHLH domain.	Tryptophan	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
22891766-5	2012	In this novel mechanism, TWIST1-mediated IL8 transcription is induced through the TWIST1 carboxy-terminal WR (Trp-Arg) domain instead of the classic DNA binding bHLH domain.	Arginine	114-117	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
22883023-8	2012	Serum levels of IL6 and IL8 also increased in the arsenic exposed group.	Arsenic	50-57	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
22634165-9	2012	Our results showed that splitomicin inhibited superoxide anion production by fMLP (1 muM) and NaF (20mM) in a concentration-dependent manner (37.5-450 muM).	splitomicin	24-35	C-X-C motif chemokine ligand 8	Homo sapiens	94-97
22634165-9	2012	Our results showed that splitomicin inhibited superoxide anion production by fMLP (1 muM) and NaF (20mM) in a concentration-dependent manner (37.5-450 muM).	Superoxides	46-62	C-X-C motif chemokine ligand 8	Homo sapiens	94-97
22867088-15	2012	In addition, pretreatment of HBEC with the antioxidant N-acetyl cysteine significantly inhibited DEP-induced ERK and Akt phosphorylation, and subsequent IL-8 and IL-1beta expression.	dep	97-100	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
22661653-8	2012	Quercetin reduced IL-6, IL-8 and TNFalpha protein production in supernatants of all GO samples (n=4) in a dose-dependent manner; however, only the reduction in IL-6 was statistically significant (p&lt;0.05).	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
22427536-7	2012	Studies performed using BEAS-2B cells showed that pretreatment with heparin and syndecan-4 decreased the expression of CXCL8 mRNA in response to LPS and TNF-alpha.	Heparin	68-75	C-X-C motif chemokine ligand 8	Homo sapiens	119-124
22523282-5	2012	The role of TAK1 in CS-induced IL-8 release is not known.	Cesium	20-22	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
22523282-7	2012	Stimulation of these cells with CS extract (CSE) increased IL-8 release and ERK-1/2 phosphorylation, as well as Ikappa-Balpha degradation and p65 NF-kappaB subunit phosphorylation.	Cesium	32-34	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
22579587-2	2012	The carrageenan-induced inflammatory cascades involve toll-like receptor (TLR)4- and B-cell leukemia/lymphoma (BCL)10-dependent activation of NF-kappaB, leading to increased IL-8 production.	Carrageenan	4-15	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
22579587-7	2012	Prolonged inflammation follows activation of the BCL10-NFkappaB inflammatory loop in response to carrageenan, shown by increased BCL10, RelA, and IL-8 for 36 to 48h and increased RelB for 24h following withdrawal of carrageenan after 12h.	Carrageenan	97-108	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
22300324-7	2012	KEY RESULTS: TGF-beta (40-400 pM) reduced the maximum inhibitory effect of dexamethasone on IL-1alpha-induced IL-6 and CXCL8 production.	Dexamethasone	75-88	C-X-C motif chemokine ligand 8	Homo sapiens	119-124
22661653-9	2012	Quercetin had a significant suppression of tissue IL-6, IL-8, IL-1beta and TNFalpha mRNA expression in cultured orbital tissues from three GO samples relative to untreated control tissue (p&lt;0.05).	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
21750917-1	2012	The aim of this study was to evaluate the remineralization potential of three silica-containing NaF dentifrice systems in an intraoral model.	Silicon Dioxide	78-84	C-X-C motif chemokine ligand 8	Homo sapiens	96-99
22578660-3	2012	Two sodium fluoride (NaF) solutions at 10% and 3% were prepared, and they had the same fluoride ion concentrations as 38% and 12% SDF, respectively.	Sodium Fluoride	4-19	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
22578660-3	2012	Two sodium fluoride (NaF) solutions at 10% and 3% were prepared, and they had the same fluoride ion concentrations as 38% and 12% SDF, respectively.	Fluorides	11-19	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
22583692-7	2012	Logistic regression analysis demonstrated a significant positive association between PTU and high levels of IFN-gamma, IL-8, MIG and IP-10.	ptu	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
22728263-1	2012	UNLABELLED: We evaluated the kinetics of (18)F-sodium fluoride (NaF) and reassessed the recommended dose, optimal uptake period, and reproducibility using a current-generation PET/CT scanner.	Sodium Fluoride	47-62	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
22641358-7	2012	We found that IL-1Ra and EGCG downregulated IL-1-induced IL-6 and IL-8 release from U-2 OS cells by 65-85%.	epigallocatechin gallate	25-29	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
22687252-8	2012	In addition, KOB03 inhibited the production of inflammatory cytokines such as TNF-alpha, IL-1beta, IL-6 and IL-8 in PMA/A23187-stimulated HMC-1 mast cells by suppressing their gene expression and blocking the ERK1/2 and p38 MAPK and NF-kappaB pathways.	Calcimycin	120-126	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
22775995-5	2012	The COL17-deficient cells showed an abnormally high IL-8 response after treatment with lipopolysaccharide (LPS), ultraviolet-B radiation or tumor necrosis factor, but exhibited a blunted IL-8 response to phorbol 12-myristate 13-acetate exposure.	Tetradecanoylphorbol Acetate	204-235	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
22527144-5	2012	Moreover, pretreatment with apigenin partially inhibited the DEHP-induced activation of c-Jun N-terminal kinase (JNK) but not the degradation of IkappaBalpha or the phosphorylation of extracellular-regulated kinase (ERK)1/2, indicating that the inhibitory effect of apigenin on the expression of IL-6, IL-8, and ICAM-1 may be mediated by JNK pathway but not IkappaBalpha/nuclear factor-kappaB or ERK/mitogen-activated protein kinase pathway.	Apigenin	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	302-306
22759480-8	2012	Confirmatory analyses identified associations of interleukin 6, interleukin 8, VEGF, osteopontin, E-selectin, and HGF with continuous tumour shrinkage or PFS in patients treated with pazopanib.	pazopanib	183-192	C-X-C motif chemokine ligand 8	Homo sapiens	64-77
22577802-8	2012	Imiquimod induced IL-6 and IL-8 production in OSCC cells, suggesting the functional expression of TLR7.	Imiquimod	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
22759480-9	2012	In the validation set of samples from the phase 3 trial, patients treated with pazopanib who had high concentrations (relative to median) of interleukin 8 (p=0 006), osteopontin (p=0 0004), HGF (p=0 010), and TIMP-1 (p=0 006) had shorter PFS than did those with low concentrations.	pazopanib	79-88	C-X-C motif chemokine ligand 8	Homo sapiens	141-154
22812506-5	2012	The antioxidant Trolox in part prevented the detrimental effect of NMs on cell viability, and decreased the NM induced IL8 production after exposure to all but the Ag particulate.	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	16-22	C-X-C motif chemokine ligand 8	Homo sapiens	119-122
22849850-9	2012	The release of IL-8 was inhibited by the NF-kappaB inhibitor, caffeic acid phenethyl ester (CAPE), an inhibitor of nuclear factor kappa-B alpha (IkappaBalpha) inhibitor, BAY 11-7085, and an inhibitor of nuclear factor kappa-B kinase-2 (IKK-2) inhibitor, SC-514, but not by a c-Jun N-terminal kinase (JNK) inhibitory peptide, L-JNKi1.	caffeic acid phenethyl ester	62-90	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
22849850-9	2012	The release of IL-8 was inhibited by the NF-kappaB inhibitor, caffeic acid phenethyl ester (CAPE), an inhibitor of nuclear factor kappa-B alpha (IkappaBalpha) inhibitor, BAY 11-7085, and an inhibitor of nuclear factor kappa-B kinase-2 (IKK-2) inhibitor, SC-514, but not by a c-Jun N-terminal kinase (JNK) inhibitory peptide, L-JNKi1.	caffeic acid phenethyl ester	92-96	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
22849850-9	2012	The release of IL-8 was inhibited by the NF-kappaB inhibitor, caffeic acid phenethyl ester (CAPE), an inhibitor of nuclear factor kappa-B alpha (IkappaBalpha) inhibitor, BAY 11-7085, and an inhibitor of nuclear factor kappa-B kinase-2 (IKK-2) inhibitor, SC-514, but not by a c-Jun N-terminal kinase (JNK) inhibitory peptide, L-JNKi1.	BAY 11-7085	170-181	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
22849850-9	2012	The release of IL-8 was inhibited by the NF-kappaB inhibitor, caffeic acid phenethyl ester (CAPE), an inhibitor of nuclear factor kappa-B alpha (IkappaBalpha) inhibitor, BAY 11-7085, and an inhibitor of nuclear factor kappa-B kinase-2 (IKK-2) inhibitor, SC-514, but not by a c-Jun N-terminal kinase (JNK) inhibitory peptide, L-JNKi1.	SC 514	254-260	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
22849850-10	2012	25-HC significantly potentiated IL-8 release in poly(I:C)-treated cells and the augmentation was inhibited by CAPE, BAY 11-7085, and SC-514.	-hc	2-5	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
22849850-10	2012	25-HC significantly potentiated IL-8 release in poly(I:C)-treated cells and the augmentation was inhibited by CAPE, BAY 11-7085, and SC-514.	Poly I	48-54	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
22849850-10	2012	25-HC significantly potentiated IL-8 release in poly(I:C)-treated cells and the augmentation was inhibited by CAPE, BAY 11-7085, and SC-514.	Carbon	55-57	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
22411631-5	2012	The specific mitogen-activated protein kinase kinase/ERK inhibitor, U0126, blocks N. fowleri-mediated AP-1 activation and subsequent IL-8 induction.	U 0126	68-73	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
22546485-7	2012	RESULTS: Both long-acting beta(2) agonists, salmeterol and formoterol, and corticosteroids, fluticasone and budesonide, showed anti-inflammatory effects to a certain extent on H(2)O(2)-induced IL-8 and MMP-9 release in alveolar macrophages.	Fluticasone	92-103	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
22546485-7	2012	RESULTS: Both long-acting beta(2) agonists, salmeterol and formoterol, and corticosteroids, fluticasone and budesonide, showed anti-inflammatory effects to a certain extent on H(2)O(2)-induced IL-8 and MMP-9 release in alveolar macrophages.	Budesonide	108-118	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
22609641-3	2012	Benzylpenicillin and phenoxymethylpenicillin were recognized as sensitizing compounds because they are capable to induce the mRNA expression of these genes in moDCs and, except for IL-8, in THP-1 cells but not in MUTZ-LC.	Penicillin G	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
22609641-3	2012	Benzylpenicillin and phenoxymethylpenicillin were recognized as sensitizing compounds because they are capable to induce the mRNA expression of these genes in moDCs and, except for IL-8, in THP-1 cells but not in MUTZ-LC.	Penicillin V	21-44	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
22444322-6	2012	In addition, the influence of long-chain hyaluronan, chondroitin sulfate, and heparin on IL-8-induced chemotaxis and oxidative activity of neutrophils was examined.	Heparin	78-85	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
22444322-0	2012	The influence of glycosaminoglycans on IL-8-mediated functions of neutrophils.	Glycosaminoglycans	17-35	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
22816782-3	2012	The migration patterns for individual cells were tracked and quantitatively analyzed, and the results suggest a hierarchy among these chemoattractants of fMLP &gt; CXCL8 &gt; CXCL2 &gt; leukotriene B(4).	Leukotrienes	186-197	C-X-C motif chemokine ligand 8	Homo sapiens	164-169
22444322-7	2012	Only the incubation of heparin with IL-8 affected the IL-8-mediated chemotaxis of neutrophils.	Heparin	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
22444322-7	2012	Only the incubation of heparin with IL-8 affected the IL-8-mediated chemotaxis of neutrophils.	Heparin	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
22444322-4	2012	Here, we investigated the interaction of heparin hexasaccharides and recombinant human IL-8, consisting of 77 amino acids using fluorescence and NMR spectroscopy.	heparin hexasaccharides	41-64	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
22444322-8	2012	However, all investigated GAGs enhanced the IL-8-induced formation of reactive oxygen species in neutrophils, which is an entirely new finding.	Reactive Oxygen Species	70-93	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
24049649-5	2012	Nevertheless, several parameters participating in oxidative stress (increased ROS production and apoptosis, decreased total thiol content) were observed in IB3-1 cells cultured in hypertonic environment as compared to S9 cells and were inhibited by diphenyleneiodonium (DPI), a well-known inhibitor of NOXs; besides, increased production of the proinflammatory cytokines IL-6 and IL-8 by IB3-1 cells was also inhibited by DPI as compared to S9 cells.	diphenyleneiodonium	249-268	C-X-C motif chemokine ligand 8	Homo sapiens	380-384
22020623-7	2012	Therefore, development of specific or multi-targeted inhibitors for these kinases for combinatorial therapy with e.g., an IL-8 neutralizing antibody might circumvent or substantially delay Sunitinib resistance formation and enhance survival prognosis.	Sunitinib	189-198	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
22364122-5	2012	In particular, a glucose-lysine (Glu-Lys) mixture heated for 60 min had marked intracellular antioxidant activity and nitric oxide (NO) and interleukin-8 (IL-8) inhibitory activities compared to other MRPs (P &lt; 0.05).	glucose-lysine	17-31	C-X-C motif chemokine ligand 8	Homo sapiens	140-153
22364122-5	2012	In particular, a glucose-lysine (Glu-Lys) mixture heated for 60 min had marked intracellular antioxidant activity and nitric oxide (NO) and interleukin-8 (IL-8) inhibitory activities compared to other MRPs (P &lt; 0.05).	glucose-lysine	17-31	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
22364122-5	2012	In particular, a glucose-lysine (Glu-Lys) mixture heated for 60 min had marked intracellular antioxidant activity and nitric oxide (NO) and interleukin-8 (IL-8) inhibitory activities compared to other MRPs (P &lt; 0.05).	Glutamic Acid	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	140-153
22364122-5	2012	In particular, a glucose-lysine (Glu-Lys) mixture heated for 60 min had marked intracellular antioxidant activity and nitric oxide (NO) and interleukin-8 (IL-8) inhibitory activities compared to other MRPs (P &lt; 0.05).	Glutamic Acid	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
22364122-5	2012	In particular, a glucose-lysine (Glu-Lys) mixture heated for 60 min had marked intracellular antioxidant activity and nitric oxide (NO) and interleukin-8 (IL-8) inhibitory activities compared to other MRPs (P &lt; 0.05).	Lysine	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	140-153
22364122-5	2012	In particular, a glucose-lysine (Glu-Lys) mixture heated for 60 min had marked intracellular antioxidant activity and nitric oxide (NO) and interleukin-8 (IL-8) inhibitory activities compared to other MRPs (P &lt; 0.05).	Lysine	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
22364122-7	2012	F3 inhibited NO, inducible nitric oxide synthetase (iNOS), and IL-8 in interferon gamma (IFN-gamma)- and phorbol ester (PMA)-induced Caco-2 cells.	Tetradecanoylphorbol Acetate	120-123	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
22517618-5	2012	Using selective EP receptor agonists and a selective EP(4) antagonist, we show that PGE(2) mediates the repression of IL-1beta-induced release of CXCL8, CCL2, and CSF2 via activation of the EP(2) and EP(4) receptors.	Prostaglandins E	84-87	C-X-C motif chemokine ligand 8	Homo sapiens	146-151
24049649-6	2012	Furthermore, calcium ionophore (A23187), which upregulates DUOX and NOX2 activities, strongly induced oxidative stress and IL-8 and IL-6 overexpression in IB3-1 cells.	Calcium	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
24049649-6	2012	Furthermore, calcium ionophore (A23187), which upregulates DUOX and NOX2 activities, strongly induced oxidative stress and IL-8 and IL-6 overexpression in IB3-1 cells.	Calcimycin	32-38	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
22407301-9	2012	A dramatic loss of immunoreactive IL-8 was observed for only one of the three TiO2 particle types tested.	titanium dioxide	78-82	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
22620679-11	2012	The effect of exosomes to promote LTC(4) and IL-8 release in BEC was significantly increased for exosomes from asthmatics, and the CysLT(1) receptor antagonist Montelukast reduced exosome-induced IL-8 secretion.	montelukast	160-171	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
22964618-2	2012	This enzyme deficiency results in an accumulation of sphingolipids in the cells of GD patients, which may contribute to the dysregulation of the immune system, B-cell dysfunction and expression of specific cytokines such as interleukin (IL) -1, IL-6, IL-8, IL-10, and tumor necrosis factor (TNF).	Sphingolipids	53-66	C-X-C motif chemokine ligand 8	Homo sapiens	251-255
22547109-10	2012	We further showed that RO429097 inhibits normal T-cell synthesis of some inflammatory cytokines, including TNF-alpha, a potential mediator of IL-6 and IL-8 production in the microenvironment.	ro429097	23-31	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
23507865-4	2012	Regulatory aspects of the interplay between IL-8 and heparan sulfate, the most abundant glycosaminoglycan, are highlighted.	Glycosaminoglycans	88-105	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
23507865-5	2012	In this field, the large natural heterogeneity of glycosaminoglycans represents a great challenge that impedes the modeling of IL-8 functions.	Glycosaminoglycans	50-68	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
23507865-6	2012	The interaction of IL-8 with newly developed artificial sulfated hyaluronan derivatives is also considered as these artificial substrates are an important tool for development of new materials in regenerative medicine.	Hyaluronic Acid	65-75	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
22543056-7	2012	TLR3-induced TSLP, TNFalpha, CXCL8, and IFNbeta mRNA and protein levels were dose-dependently and non-selectively inhibited by capsazepine, equally in cells from asthmatic and COPD donors.	capsazepine	127-138	C-X-C motif chemokine ligand 8	Homo sapiens	29-34
22610073-11	2012	Further, IL-8-promoted migration and invasion could be abolished by either the application of the phosphoinositide-3-kinase inhibitor LY294002 or the knock down of AKT expression by using small-interfering RNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
23121969-0	2012	Regulation of Salmonella flagellin-induced interleukin-8 in intestinal epithelial cells by muramyl dipeptide.	Dipeptides	99-108	C-X-C motif chemokine ligand 8	Homo sapiens	43-56
23121969-4	2012	Therefore the aim of the study is to investigate regulation of Salmonella flagellin-induced interleukin (IL)-8 (IL-8) in IECs by Nod2 agonist, muramyl dipeptide (MDP).	Acetylmuramyl-Alanyl-Isoglutamine	143-160	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
23121969-4	2012	Therefore the aim of the study is to investigate regulation of Salmonella flagellin-induced interleukin (IL)-8 (IL-8) in IECs by Nod2 agonist, muramyl dipeptide (MDP).	Acetylmuramyl-Alanyl-Isoglutamine	162-165	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
22437006-4	2012	However, both HKVC and the LPS showed a substantial induction of IL-8 production in IFN-gamma-primed HT-29 cells.	hkvc	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
22626465-0	2012	Astaxanthin attenuates the UVB-induced secretion of prostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner.	astaxanthine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	73-86
22626465-1	2012	To elucidate the effects of redox balance regulation on cutaneous inflammation, we used the potent antioxidant astaxanthin (AX) to assess its effect on the UVB-induced secretion of PGE(2) and IL-8 in human keratinocytes and analysed its biological mechanism of action.	astaxanthine	111-122	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
22626465-9	2012	This may be associated with the significant suppression of PGE(2) /IL-8 secretion via the down-regulated expression of COX-2 and IL-8 at the gene and/or protein levels.	Prostaglandins E	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
22626465-9	2012	This may be associated with the significant suppression of PGE(2) /IL-8 secretion via the down-regulated expression of COX-2 and IL-8 at the gene and/or protein levels.	Prostaglandins E	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
21968713-4	2012	Both normal and immortalized human gingival epithelial (HOK-16B) cells expressed TLR9 intracellularly and showed enhanced IL-8 expression in response to CpG-oligonucleotide.	CPG-oligonucleotide	153-172	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
22561123-0	2012	Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells.	corilagin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
22561123-5	2012	The data obtained demonstrate that corilagin binds to NF-kappaB, inhibits NF-kappaB/DNA interactions and affects IL-8 gene expression in TNF-alpha treated IB3-1 cells.	corilagin	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
22543056-9	2012	Only capsazepine consistently inhibited TNFalpha and CXCL8 production and attenuated TLR3-induced epithelial NF-kappaB signalling.	capsazepine	5-16	C-X-C motif chemokine ligand 8	Homo sapiens	53-58
22538414-3	2012	Amphotericin B alone elicited a slight increase in interleukin (IL)-6 and IL-8 production by human gingival fibroblasts.	Amphotericin B	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
22538414-4	2012	However, amphotericin B synergistically up-regulated lipid A-induced production of IL-6 and IL-8.	Amphotericin B	9-23	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
22538414-4	2012	However, amphotericin B synergistically up-regulated lipid A-induced production of IL-6 and IL-8.	Lipid A	53-60	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
22211698-0	2012	Interleukin-17- and protease-activated receptor 2-mediated production of CXCL1 and CXCL8 modulated by cyclosporine A, vitamin D3 and glucocorticoids in human keratinocytes.	Cyclosporine	102-116	C-X-C motif chemokine ligand 8	Homo sapiens	83-88
22538414-6	2012	Pre-treatment with methyl-beta-cyclodextrin (MbetaCD), a cholesterol-binding agent, reduced IL-6 and IL-8 production in human gingival fibroblasts.	methyl-beta-cyclodextrin	19-43	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
22211698-0	2012	Interleukin-17- and protease-activated receptor 2-mediated production of CXCL1 and CXCL8 modulated by cyclosporine A, vitamin D3 and glucocorticoids in human keratinocytes.	Cholecalciferol	118-128	C-X-C motif chemokine ligand 8	Homo sapiens	83-88
22211698-4	2012	The SLIGKV-NH(2) -induced production of both CXCL1 and CXCL8 was markedly reduced by cyclosporine A.	Cyclosporine	85-99	C-X-C motif chemokine ligand 8	Homo sapiens	55-60
22538414-6	2012	Pre-treatment with methyl-beta-cyclodextrin (MbetaCD), a cholesterol-binding agent, reduced IL-6 and IL-8 production in human gingival fibroblasts.	methyl-beta-cyclodextrin	45-52	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
22562653-8	2012	Pretreatment with DHT inhibited NF-kappaB activation and suppressed secretion of several inflammatory/growth factors, with the most pronounced effects on IL8, IL6, and bFGF.	Dihydrotestosterone	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	154-157
22460770-11	2012	Asymmetric dimethylarginine was inversely correlated with organ dysfunction by Pediatric Logistic Organ Dysfunction score (r = -0.50, p = .009), interleukin-6 (r = -0.55, p = .01), and interleukin-8 (r = -0.52, p = .03) on admission.	dimethylarginine	11-27	C-X-C motif chemokine ligand 8	Homo sapiens	185-198
22425623-10	2012	The ER accumulation of Z-AT was shown to induce PERK-dependent NF-kappaB, IL-6, IL-8, and RGS16 and calnexin; all of which could be abrogated effectively by 4M.	z-at	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
22512945-4	2012	COS induced up-regulation of a total of 11 genes including CCL20 and IL8 and concurrent down-regulation of 10 genes including pro-inflammatory mediators CCL15, CCL25 and IL1B.	oligochitosan	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
22520513-3	2012	The action of glutamate on the secretion of IL-8 and IL-10 by lymphocytes derived from healthy subjects and cystic CF patients, as well as the expression of metabotropic glutamate receptor subtype 1 (mGluR1) in the membrane fractions of lymphocytes was investigated.	Glutamic Acid	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
22183741-7	2012	In addition, treatment of endometriotic stromal cells with curcumin markedly inhibited TNF-alpha-induced secretion of IL-6, IL-8 and MCP-1.	Curcumin	59-67	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
22313893-11	2012	Additionally, we also found that 25-OH decreases the levels of IkappaB and increases the nuclear levels of NF-kappaB p65 subunit and that inhibition of NF-kappaB activity partially prevents the increased secretion of IL-8 induced by 25-OH.	25-oh	33-38	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
27157456-2	2012	(18)F-labeled sodium fluoride (NaF) PET with computed tomography (PET/CT) is a promising tool for the evaluation of benign bone disease.	Sodium Fluoride	14-29	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
27157457-2	2012	(18)F-Labeled sodium fluoride ((18)F NaF) is a positron-emitting radiopharmaceutical with desirable characteristics (rapid blood clearance and bone uptake) for high-quality functional imaging of the skeleton.	Sodium Fluoride	14-29	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
27157459-1	2012	Skeletal imaging of children with fluorine-18 ((18)F) NaF harnesses the superior imaging characteristics of positron emission tomography (PET) and the improved biodistribution of the fluoride tracer compared with standard nuclear techniques, resulting in excellent quality images.	Fluorine	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
27157459-1	2012	Skeletal imaging of children with fluorine-18 ((18)F) NaF harnesses the superior imaging characteristics of positron emission tomography (PET) and the improved biodistribution of the fluoride tracer compared with standard nuclear techniques, resulting in excellent quality images.	Fluorides	183-191	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
27157462-1	2012	Detection of early ongoing cardiovascular molecular calcification and its quantification through (18)F-labeled sodium fluoride ((18)F NaF) PET/computed tomography (CT) imaging has been a recent addition to the diagnostic armamentarium of molecular imaging for the atherosclerotic process.	Sodium Fluoride	111-126	C-X-C motif chemokine ligand 8	Homo sapiens	134-137
22012204-12	2012	The levels of IL-6 and IL-8 were significantly reduced at 4 weeks after intravitreal MTX, whereas those of vascular endothelial growth factor and monocyte chemotactic protein 1 were not reduced.	Methotrexate	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
22012204-14	2012	Intravitreal MTX was associated with a significant reduction of IL-6 and IL-8 levels and was effective and well tolerated even in steroid responders with refractory retinal vasculitis due to Behcet disease.	Methotrexate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
22429778-11	2012	Ocular irradiation from a Ru-106 plaque promoted an increase in the levels of IL-6, IL-8 and IL-1beta, modulation of which could be useful in managing radiation-related side effects.	Ruthenium-106	26-32	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
22147632-7	2012	However, conditioned medium from CD4+ T cells cultured with tofacitinib inhibited IL-6 production by RASFs and IL-8 production by CD14+ monocytes.	tofacitinib	60-71	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
22147632-8	2012	Treatment of SCID-HuRAg mice with tofacitinib decreased serum levels of human IL-6 and IL-8 and markedly suppressed invasion of synovial tissue into cartilage.	tofacitinib	34-45	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
22147632-9	2012	CONCLUSION: Tofacitinib directly suppressed the production of IL-17 and IFNgamma and the proliferation of CD4+ T cells, resulting in inhibition of IL-6 production by RASFs and IL-8 production by CD14+ cells and decreased cartilage destruction.	tofacitinib	12-23	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
22459196-4	2012	Together with results obtained using N-acetylcystein (NAC), we were able to clearly show that low level and early stage exposure to 5 nm silver nanoparticles, but not 100 nm, induces expression of IL-8 as well as stress genes against reactive oxygen species (ROS).	Silver	137-143	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
22546346-0	2012	Dexamethasone reduces bilirubin-induced toxicity and IL-8 and MCP-1 release in human NT2-N neurons.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
22313893-0	2012	Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells.	25-hydroxycholesterol	57-78	C-X-C motif chemokine ligand 8	Homo sapiens	32-45
22313893-4	2012	PI3K-, MEK1/2-, ERK1/2- and NF-kappaB-specific inhibitors were used to assess the specific role of the several players on the regulation of IL-8 production by oxysterols.	Oxysterols	159-169	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
22313893-7	2012	Indeed, treatment of ARPE-19 with 25-OH, but not with 7-KC, 7beta-OH or cholesterol, induced the secretion of IL-8 from cells.	25-oh	34-39	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
22281986-5	2012	Pre-exposure to FRH increased in vivo IL-8-directed PMN TAM by 23.5-fold and in vitro TEM by 7-fold.	frh	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
22147632-5	2012	RESULTS: Tofacitinib treatment of CD4+ T cells originating from synovium and peripheral blood inhibited the production of interleukin-17 (IL-17) and interferon-gamma (IFNgamma) in a dose-dependent manner, affecting both proliferation and transcription, but had no effect on IL-6 and IL-8 production.	tofacitinib	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	283-287
22326254-0	2012	Association of serum levels of polychlorinated biphenyls with IL-8 mRNA expression in blood samples from asthmatic and non-asthmatic Japanese children.	Polychlorinated Biphenyls	31-56	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
22884152-9	2012	Parthenolide decreased the levels of the angiogenic factors MMP-9, VEGF, and IL-8 secreted by the MDA-MB-231 cells.	parthenolide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
22313893-11	2012	Additionally, we also found that 25-OH decreases the levels of IkappaB and increases the nuclear levels of NF-kappaB p65 subunit and that inhibition of NF-kappaB activity partially prevents the increased secretion of IL-8 induced by 25-OH.	25-oh	233-238	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
22313893-12	2012	CONCLUSIONS: The results presented in this study suggest a role for 25-OH in inducing IL-8 production through pathways that are likely to involve AP-1 and NF-kappaB in ARPE-19 cells.	25-oh	68-73	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
22481026-8	2012	CFTR(inh172) also altered the release of inflammation mediators PGE(2) and IL-8, and this effect was blunted by exogenous 15d-PGJ(2).	15d-pgj	122-129	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
21932059-0	2012	ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPK in human umbilical vein endothelial cells.	Curcumin	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
21932059-5	2012	Pretreatment with curcumin dose-dependently decreased DEHP-induced expression of ICAM-1 and IL-8 as well as phosphorylation of ERK1/2 and p38.	Curcumin	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
21932059-5	2012	Pretreatment with curcumin dose-dependently decreased DEHP-induced expression of ICAM-1 and IL-8 as well as phosphorylation of ERK1/2 and p38.	Diethylhexyl Phthalate	54-58	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
21932059-6	2012	Preincubation with ERK1/2 inhibitor (PD98059) or p38 inhibitor (SB203580) markedly blocked DEHP-stimulated activation of ICAM-1 and IL-8.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	37-44	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
21932059-6	2012	Preincubation with ERK1/2 inhibitor (PD98059) or p38 inhibitor (SB203580) markedly blocked DEHP-stimulated activation of ICAM-1 and IL-8.	SB 203580	64-72	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
21932059-6	2012	Preincubation with ERK1/2 inhibitor (PD98059) or p38 inhibitor (SB203580) markedly blocked DEHP-stimulated activation of ICAM-1 and IL-8.	Diethylhexyl Phthalate	91-95	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
21932059-7	2012	We suggest that curcumin inhibits DEHP-induced expression of ICAM-1 and IL-8 through ERK and p38 MAPK signaling pathways in HUVECs and may contribute to ameliorate pathologies of DEHP-related allergic disorders.	Curcumin	16-24	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
21932059-7	2012	We suggest that curcumin inhibits DEHP-induced expression of ICAM-1 and IL-8 through ERK and p38 MAPK signaling pathways in HUVECs and may contribute to ameliorate pathologies of DEHP-related allergic disorders.	Diethylhexyl Phthalate	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
21932059-7	2012	We suggest that curcumin inhibits DEHP-induced expression of ICAM-1 and IL-8 through ERK and p38 MAPK signaling pathways in HUVECs and may contribute to ameliorate pathologies of DEHP-related allergic disorders.	Diethylhexyl Phthalate	179-183	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
21967620-0	2012	Evaluation of the tear and serum levels of IL-8 in sulfur mustard intoxicated patients 20 years after exposure.	Mustard Gas	51-65	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
22768761-5	2012	RESULTS: The total amounts of IL-8 and GCF volume in the Ni-Cr alloy coated porcelain teeth were higher in different time period than those before treatment (P&lt;0.05).	ni-cr	57-62	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
22768761-9	2012	Therefore, the level of IL-8 in GCF is a useful criteria for the evaluation of stimulation degree on gingiva by different alloy coating materials in porcelain teeth.	Alloys	122-127	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
22498762-12	2012	Curcumin also inhibited the TNF-alpha-induced production of IL-6/IL-8 in HaCaT cells.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
22324515-9	2012	Interleukin-8 and vascular endothelial growth factor transcripts were induced after neuropeptides treatment, but downregulated by bortezomib.	Bortezomib	130-140	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
22556343-4	2012	Assessing the regulatory function of miR-93/106b through doxycycline-inducible lentiviral transduction in a microarray analysis, tissue factor (F3) and IL8 were identified as their possible targets.	Doxycycline	57-68	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
21938724-0	2012	Imatinib treatment inhibit IL-6, IL-8, NF-KB and AP-1 production and modulate intracellular calcium in CML patients.	Imatinib Mesylate	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
21938724-7	2012	Our results demonstrated a significant down-regulation in IL-6 and IL-8 release as well as NF-kB and AP-1 activation in lymphomonocytes from Imatinib-treated patients, compared to samples from untreated patients.	Imatinib Mesylate	141-149	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
21938724-9	2012	The results of this study show that measurements of NF-kB, AP-1, IL-6, IL-8, and intracellular calcium in CML patients treated with Imatinib may give important information to the hematologist on diagnostic criteria and are highly predictive in patients with newly diagnosed CML.	Imatinib Mesylate	132-140	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
22009527-0	2012	Enhancement of interleukin-8-induced chemotactic response and reactive oxygen species production in HL-60 cells expressing CXCR1.	Reactive Oxygen Species	62-85	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
22009527-5	2012	When these cell lines were primed with CXC chemokine ligand 8 (IL-8), a slight increase in reactive oxygen species production induced by phorbol myristate acetate (PMA) or zymosan A stimuli was observed.	Reactive Oxygen Species	91-114	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
22009527-5	2012	When these cell lines were primed with CXC chemokine ligand 8 (IL-8), a slight increase in reactive oxygen species production induced by phorbol myristate acetate (PMA) or zymosan A stimuli was observed.	Tetradecanoylphorbol Acetate	137-162	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
22009527-5	2012	When these cell lines were primed with CXC chemokine ligand 8 (IL-8), a slight increase in reactive oxygen species production induced by phorbol myristate acetate (PMA) or zymosan A stimuli was observed.	Tetradecanoylphorbol Acetate	164-167	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
22009527-5	2012	When these cell lines were primed with CXC chemokine ligand 8 (IL-8), a slight increase in reactive oxygen species production induced by phorbol myristate acetate (PMA) or zymosan A stimuli was observed.	Zymosan	172-181	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
21840193-9	2012	These results suggest that linoleic acid-induced changes in monocyte chemotaxis and subsequent binding are not solely mediated by changes in adhesion molecule expression but may be due to secreted factors such as IL-8, monocyte chemoattractant protein-1 or prostaglandins (PGs) such as PGE(2), as IL-8 neutralisation and COX-2 inhibition reduced monocyte binding without changes in adhesion molecule expression.	Linoleic Acid	27-40	C-X-C motif chemokine ligand 8	Homo sapiens	213-217
21840193-9	2012	These results suggest that linoleic acid-induced changes in monocyte chemotaxis and subsequent binding are not solely mediated by changes in adhesion molecule expression but may be due to secreted factors such as IL-8, monocyte chemoattractant protein-1 or prostaglandins (PGs) such as PGE(2), as IL-8 neutralisation and COX-2 inhibition reduced monocyte binding without changes in adhesion molecule expression.	Linoleic Acid	27-40	C-X-C motif chemokine ligand 8	Homo sapiens	297-301
22571267-7	2012	TFB intervention may significantly suppressed the supernatant IL-8, TNF-alpha and NO levels of HUVEC.	tfb	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
22421092-3	2012	This study aimed to compare the surface rehardening and fluoride uptake effect of 2%-NaF solutions at different pH on non-cavitated caries-like lesions with two different levels of demineralization.	Fluorides	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
22464230-6	2012	RESULTS: Kojic acid increased interleukin (IL)-6 and IL-8 production in melanocyte/keratinocyte co-cultures; however, IL-6 directly inhibited melanogenesis whereas IL-8 did not.	kojic acid	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
22464230-6	2012	RESULTS: Kojic acid increased interleukin (IL)-6 and IL-8 production in melanocyte/keratinocyte co-cultures; however, IL-6 directly inhibited melanogenesis whereas IL-8 did not.	kojic acid	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
22768425-5	2012	After 24h of treatment, IL-8 protein release from A549 cells, induced by 10, 50 and 250 microg/ml of P25 TiO2 NPs, were statistically significantly raised, compared to that of the control.	titanium dioxide	105-109	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
22768425-6	2012	This finding corroborates existing literature in that TiO2 NPs induce a dose-dependent increase in the release of IL-8 protein when exposed to A549 cells.	titanium dioxide	54-58	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
22401993-3	2012	Corticosteroid sensitivity was determined as IC50 to dexamethasone (Dex) on TNFalpha-induced IL-8 release in a U937 monocytic cell line (Dex-IC50).	Dexamethasone	53-66	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
22401993-3	2012	Corticosteroid sensitivity was determined as IC50 to dexamethasone (Dex) on TNFalpha-induced IL-8 release in a U937 monocytic cell line (Dex-IC50).	Dexamethasone	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
22932481-1	2012	OBJECTIVE: To investigate the effects of 17-beta estradiol (E(2)) and Porphyromonas gingivalis (Pg) W83 on the expression of interleukin (IL)-6 and IL-8 in human periodontal ligament cells (hPDLC).	Estradiol	41-58	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
22574737-10	2012	RESULTS: Compared with placebo, butyrate therapy led to the early reduction of macrophages, pus cells, IL-8 and IL-1beta in the stool and improvement in rectal histopathology.	Butyrates	32-40	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
22387535-2	2012	In this study I found that biochanin, a methoxy form of genistein, inhibits IL-8-mediated activation of nuclear transcription factor kappaB (NF-kappaB) and activator protein 1 (AP-1) more potently than genistein as shown in Jurkat T-cell line.	Genistein	56-65	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
22387535-2	2012	In this study I found that biochanin, a methoxy form of genistein, inhibits IL-8-mediated activation of nuclear transcription factor kappaB (NF-kappaB) and activator protein 1 (AP-1) more potently than genistein as shown in Jurkat T-cell line.	Genistein	202-211	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
22181939-4	2012	TLRs expression was examined by RT-PCR and IL-8 production by poly I:C was examined by ELISA.	poly I:C	62-70	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
21344174-8	2012	Theanine also repressed phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced TNF-alpha, IL-1beta, IL-6, and IL-8 secretion by suppressing NF-kappaB activation.	theanine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
22059850-6	2012	RESULTS: Short-chain fatty acids, at 20 mM, induced interleukin (IL)-8, IL-6, and IL-1beta release, while lower levels (0.02-2 mM) did not induce cytokine secretion.	Fatty Acids, Volatile	9-32	C-X-C motif chemokine ligand 8	Homo sapiens	52-70
21344174-8	2012	Theanine also repressed phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced TNF-alpha, IL-1beta, IL-6, and IL-8 secretion by suppressing NF-kappaB activation.	Calcimycin	78-84	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
22465753-0	2012	Lysophosphatidic acid induces lymphangiogenesis and IL-8 production in vitro in human lymphatic endothelial cells.	lysophosphatidic acid	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
22465753-5	2012	In addition, LPA induces IL-8 expression by enhancing IL-8 promoter activity via activation of the NF-kappaB pathway in LECs.	lysophosphatidic acid	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
22465753-5	2012	In addition, LPA induces IL-8 expression by enhancing IL-8 promoter activity via activation of the NF-kappaB pathway in LECs.	lysophosphatidic acid	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
22465753-6	2012	Using IL-8 siRNA and IL-8 neutralizing antibody, we revealed that IL-8 plays an important role in LPA-induced lymphangiogenesis in vitro.	lysophosphatidic acid	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
22465753-6	2012	Using IL-8 siRNA and IL-8 neutralizing antibody, we revealed that IL-8 plays an important role in LPA-induced lymphangiogenesis in vitro.	lysophosphatidic acid	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
22465753-6	2012	Using IL-8 siRNA and IL-8 neutralizing antibody, we revealed that IL-8 plays an important role in LPA-induced lymphangiogenesis in vitro.	lysophosphatidic acid	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
22465753-7	2012	Moreover, using siRNA inhibition, we discovered that LPA-induced lymphangiogenesis in vitro and IL-8 production are mediated via the LPA(2) receptor in LECs.	lysophosphatidic acid	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
22465753-8	2012	Finally, using human sentinel afferent lymphatic vessel explants, we demonstrated that LPA up-regulates IL-8 production in the LECs of lymphatic endothelia.	lysophosphatidic acid	87-90	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
22465753-9	2012	These studies provide the first evidence that LPA promotes lymphangiogenesis and induces IL-8 production in LECs; we also reveal a possible new role of LPA in the promotion of tumor progression, as well as metastasis, in different cancer types.	lysophosphatidic acid	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
22402363-3	2012	The oxidation products of phospholipids, including oxidized 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine (Ox-PAPC), accumulate in atherosclerotic lesions and strongly induce IL-8 in human aortic endothelial cells (HAECs).	Phospholipids	26-39	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
22271211-2	2012	In this study, data collected on RHE exposed to well-characterized sensitizing chemicals, such as dinitrofluorobenzene, oxazolone, cinnamaldehyde and isoeugenol, revealed a transient expression of IL-8 mRNA in association with abundant IL-8 cell release.	Dinitrofluorobenzene	98-118	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
22271211-2	2012	In this study, data collected on RHE exposed to well-characterized sensitizing chemicals, such as dinitrofluorobenzene, oxazolone, cinnamaldehyde and isoeugenol, revealed a transient expression of IL-8 mRNA in association with abundant IL-8 cell release.	Dinitrofluorobenzene	98-118	C-X-C motif chemokine ligand 8	Homo sapiens	236-240
22271211-2	2012	In this study, data collected on RHE exposed to well-characterized sensitizing chemicals, such as dinitrofluorobenzene, oxazolone, cinnamaldehyde and isoeugenol, revealed a transient expression of IL-8 mRNA in association with abundant IL-8 cell release.	Oxazolone	120-129	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
22402363-3	2012	The oxidation products of phospholipids, including oxidized 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine (Ox-PAPC), accumulate in atherosclerotic lesions and strongly induce IL-8 in human aortic endothelial cells (HAECs).	1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine	60-114	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
22271211-2	2012	In this study, data collected on RHE exposed to well-characterized sensitizing chemicals, such as dinitrofluorobenzene, oxazolone, cinnamaldehyde and isoeugenol, revealed a transient expression of IL-8 mRNA in association with abundant IL-8 cell release.	Oxazolone	120-129	C-X-C motif chemokine ligand 8	Homo sapiens	236-240
22271211-2	2012	In this study, data collected on RHE exposed to well-characterized sensitizing chemicals, such as dinitrofluorobenzene, oxazolone, cinnamaldehyde and isoeugenol, revealed a transient expression of IL-8 mRNA in association with abundant IL-8 cell release.	cinnamaldehyde	131-145	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
22271211-2	2012	In this study, data collected on RHE exposed to well-characterized sensitizing chemicals, such as dinitrofluorobenzene, oxazolone, cinnamaldehyde and isoeugenol, revealed a transient expression of IL-8 mRNA in association with abundant IL-8 cell release.	isoeugenol	150-160	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
22271211-2	2012	In this study, data collected on RHE exposed to well-characterized sensitizing chemicals, such as dinitrofluorobenzene, oxazolone, cinnamaldehyde and isoeugenol, revealed a transient expression of IL-8 mRNA in association with abundant IL-8 cell release.	isoeugenol	150-160	C-X-C motif chemokine ligand 8	Homo sapiens	236-240
22402363-11	2012	Free thiol cysteine analogs showed inhibition of IL-8 induction by Ox-PAPC, and both a cysteine analog and a cell surface thiol blocker strongly inhibited ADAM activity induction by Ox-PAPC.	thiol-cysteine	5-19	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
22402363-11	2012	Free thiol cysteine analogs showed inhibition of IL-8 induction by Ox-PAPC, and both a cysteine analog and a cell surface thiol blocker strongly inhibited ADAM activity induction by Ox-PAPC.	Cysteine	11-19	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
22402363-11	2012	Free thiol cysteine analogs showed inhibition of IL-8 induction by Ox-PAPC, and both a cysteine analog and a cell surface thiol blocker strongly inhibited ADAM activity induction by Ox-PAPC.	Sulfhydryl Compounds	5-10	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
22285804-9	2012	We demonstrate that the synthetic glucocorticoid dexamethasone (Dex) significantly decreases IL-8 secretion, AP-1 and NF-kappaB activity in CF cells in a pro-inflammatory context.	Dexamethasone	49-62	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
22465636-2	2012	The introduction of A ring pyrazole modification to the hydrocortisone C-21 heteroaryl thioethers generated compounds with excellent transrepression potency (IL-8 inhibition) compared to their hydrocortisone analogs.	pyrazole	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
22465636-2	2012	The introduction of A ring pyrazole modification to the hydrocortisone C-21 heteroaryl thioethers generated compounds with excellent transrepression potency (IL-8 inhibition) compared to their hydrocortisone analogs.	Hydrocortisone	56-70	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
22465636-2	2012	The introduction of A ring pyrazole modification to the hydrocortisone C-21 heteroaryl thioethers generated compounds with excellent transrepression potency (IL-8 inhibition) compared to their hydrocortisone analogs.	Sulfides	87-97	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
22436383-7	2012	Dithiolethione-mediated inhibition of NF-kappaB-regulated genes resulted in the inhibition of interleukin (IL)-6, IL-8, urokinase-type plasminogen activator, and VEGF production.	dithiolethione	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
22726350-3	2012	ST, rosmarinic acid, pulegone, and 2alpha,3alpha,24-thrihydrooxylen-12en-28oic acid treatment of HMC-1 cells led to significant suppression of pro-inflammatory cytokines (IL-6, IL-8, and TNF-alpha) in a dose dependent manner.	rosmarinic acid	4-19	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
22726350-3	2012	ST, rosmarinic acid, pulegone, and 2alpha,3alpha,24-thrihydrooxylen-12en-28oic acid treatment of HMC-1 cells led to significant suppression of pro-inflammatory cytokines (IL-6, IL-8, and TNF-alpha) in a dose dependent manner.	pulegone	21-29	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
22726350-3	2012	ST, rosmarinic acid, pulegone, and 2alpha,3alpha,24-thrihydrooxylen-12en-28oic acid treatment of HMC-1 cells led to significant suppression of pro-inflammatory cytokines (IL-6, IL-8, and TNF-alpha) in a dose dependent manner.	24-thrihydrooxylen-12en-28oic acid	49-83	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
22119045-0	2012	Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1beta or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
22119045-2	2012	The aim of this study is to evaluate the effect of nicotine, a major component of cigarette smoke, on interleukin-8 (IL-8) production and cellular signalling via nicotinic acetylcholine receptors (nAChRs) in human gingival epithelial cells (HGECs).	Nicotine	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	102-115
22119045-2	2012	The aim of this study is to evaluate the effect of nicotine, a major component of cigarette smoke, on interleukin-8 (IL-8) production and cellular signalling via nicotinic acetylcholine receptors (nAChRs) in human gingival epithelial cells (HGECs).	Nicotine	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
22119045-8	2012	Nicotine increased the secretion of IL-8 from HGECs that were cultured in the presence of IL-1beta or P. gingivalis LPS and also induced the phosphorylation of extracellular signal-regulated kinase (ERK) in epi 4.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
22119045-10	2012	Furthermore, nicotine-induced IL-8 secretion was decreased by pretreatment with non-selective nAChR antagonist, ERK1/2 inhibitor or intracellular calcium chelator.	Nicotine	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
22119045-10	2012	Furthermore, nicotine-induced IL-8 secretion was decreased by pretreatment with non-selective nAChR antagonist, ERK1/2 inhibitor or intracellular calcium chelator.	Calcium	146-153	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
22119045-11	2012	CONCLUSION: These findings indicate that nicotine increases IL-8 production in gingival epithelial cells via ERK phosphorylation following Ca(2+) signalling after nAChR activation.	Nicotine	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
22471285-5	2012	Interleukin (IL)-6 and IL-8 mRNA expression and protein secretion in LPS-stimulated cells were inhibited significantly by the lipophilic statin pitavastatin and the hydrophilic statin pravastatin.	pitavastatin	144-156	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
22471285-5	2012	Interleukin (IL)-6 and IL-8 mRNA expression and protein secretion in LPS-stimulated cells were inhibited significantly by the lipophilic statin pitavastatin and the hydrophilic statin pravastatin.	Pravastatin	184-195	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
22475920-0	2012	Atlas of sodium fluoride PET bone scans: atlas of NaF PET bone scans.	Sodium Fluoride	9-24	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
22475920-1	2012	Sodium fluoride (NaF) is a bone-seeking positron-emitting tracer with high sensitivity and specificity for detection of osseous lesions, particularly osteolytic lesions.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
22367719-3	2012	In vitro, endotoxin-mediated induction of endothelial permeability and IL-8-induced transmigration of neutrophils through human microvascular endothelial cells required ADAM17 as shown by inhibition with GW280264X or shRNA-mediated knockdown.	GW280264X	204-213	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
22285804-9	2012	We demonstrate that the synthetic glucocorticoid dexamethasone (Dex) significantly decreases IL-8 secretion, AP-1 and NF-kappaB activity in CF cells in a pro-inflammatory context.	Dexamethasone	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
22285804-10	2012	Moreover, we show that p38 MAPK controls IL-8 release by determining GR activation through specific phosphorylation on serine 211.	Serine	119-125	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
22285804-11	2012	Finally, we demonstrate a synergistic effect of dexamethasone treatment and inhibition of p38 MAPK inducing more than 90% inhibition of IL-8 production in CF cells.	Dexamethasone	48-61	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
22415150-0	2012	Elevated tear interleukin-6 and interleukin-8 levels associated with silicone hydrogel and conventional hydrogel contact lens wear.	Silicones	69-77	C-X-C motif chemokine ligand 8	Homo sapiens	32-45
22415150-11	2012	CONCLUSIONS: The SH-CL and CH-CL wear is associated with elevation of IL-6 and IL-8 levels in the tears of healthy, nonatopic neophyte CL users.	ch-cl	27-32	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
22399514-12	2012	TSH induces IL-8 production at the pretranslational level.	Thyrotropin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
22267101-8	2012	Additionally, the levels of IL-6             and IL-8 mRNA induced by TNF-alpha were significantly suppressed by the addition of             cinobufocini.	cinobufocini	141-153	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
22648625-9	2012	Uro-A inhibited endothelial cell migration and was able to decrease the expression of CCL2 and interleukin-8 (IL-8).	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	95-108
22648625-9	2012	Uro-A inhibited endothelial cell migration and was able to decrease the expression of CCL2 and interleukin-8 (IL-8).	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
22399514-11	2012	These cells produce high levels of several cytokines and chemokines including IL-8, regulated upon activation, normal T cell expressed and secreted, and monocyte chemoattractant protein-1 when treated with TSH or M22.	Thyrotropin	206-209	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
21984511-5	2012	JPT and HES inhibited the H(2)O(2)-induced interleukin-8 and tumor necrosis factor-alpha production as well as its mRNA expression.	JPT	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	43-88
22045098-12	2012	The effluent concentration of interleukin 8 was significantly lower in patients using low-GDP PDF.	Guanosine Diphosphate	90-93	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
22215656-11	2012	In comparing the BicaVera and standard solution groups, MCs from the standard solution group showed significantly higher secretion of interleukin 8 and lower secretion of collagen I, but no differences in the levels of other EMT-associated molecules, including fibronectin, VEGF, E-cadherin, and transforming growth factor beta1.	mcs	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	134-147
22215656-14	2012	CONCLUSIONS: Effluent MCs grown ex vivo from patients treated with bicarbonate/low-GDP BicaVera fluid showed a trend to acquire an epithelial phenotype, with lower production of proinflammatory cytokines and chemokines (such as interleukin 8) than was seen with MCs from patients treated with a lactate-buffered standard PD solution.	mcs	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	228-241
22215656-14	2012	CONCLUSIONS: Effluent MCs grown ex vivo from patients treated with bicarbonate/low-GDP BicaVera fluid showed a trend to acquire an epithelial phenotype, with lower production of proinflammatory cytokines and chemokines (such as interleukin 8) than was seen with MCs from patients treated with a lactate-buffered standard PD solution.	Bicarbonates	67-78	C-X-C motif chemokine ligand 8	Homo sapiens	228-241
21984511-5	2012	JPT and HES inhibited the H(2)O(2)-induced interleukin-8 and tumor necrosis factor-alpha production as well as its mRNA expression.	Hesperidin	8-11	C-X-C motif chemokine ligand 8	Homo sapiens	43-88
21984511-5	2012	JPT and HES inhibited the H(2)O(2)-induced interleukin-8 and tumor necrosis factor-alpha production as well as its mRNA expression.	Hydrogen Peroxide	26-34	C-X-C motif chemokine ligand 8	Homo sapiens	43-88
22356551-1	2012	Sodium fluoride (NaF) has been shown to be cytotoxic and produces inflammatory responses in humans.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
22763297-6	2012	Serum levels of IL-8 and IL-12p40 on admission were higher in patients with SAAP than in patients with MAAP but the difference was not statistically significant.	saap	76-80	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
22763297-6	2012	Serum levels of IL-8 and IL-12p40 on admission were higher in patients with SAAP than in patients with MAAP but the difference was not statistically significant.	maap	103-107	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
22403260-4	2012	CD161(+)CD56(+)LFA-1(-) NK cells produce large amounts of CXCL8 after phorbol myristate acetate (PMA) or cytokine treatment.	Tetradecanoylphorbol Acetate	70-95	C-X-C motif chemokine ligand 8	Homo sapiens	58-63
22477013-0	2012	Phagocytosis and endocytosis of silver nanoparticles induce interleukin-8 production in human macrophages.	Silver	32-38	C-X-C motif chemokine ligand 8	Homo sapiens	60-73
22427570-7	2012	Both melphalan and carboplatin triggered human retinal endothelial cell migration, proliferation, apoptosis, and increased expression of adhesion proteins intracellullar adhesion molecule-1 [ICAM-1] and soluble chemotactic factors (IL-8).	Melphalan	5-14	C-X-C motif chemokine ligand 8	Homo sapiens	232-236
22427570-7	2012	Both melphalan and carboplatin triggered human retinal endothelial cell migration, proliferation, apoptosis, and increased expression of adhesion proteins intracellullar adhesion molecule-1 [ICAM-1] and soluble chemotactic factors (IL-8).	Carboplatin	19-30	C-X-C motif chemokine ligand 8	Homo sapiens	232-236
22403260-4	2012	CD161(+)CD56(+)LFA-1(-) NK cells produce large amounts of CXCL8 after phorbol myristate acetate (PMA) or cytokine treatment.	Tetradecanoylphorbol Acetate	97-100	C-X-C motif chemokine ligand 8	Homo sapiens	58-63
22416137-6	2012	Pretreatment of NCM460 cells with the ECE-1 inhibitor SM19712 or gene silencing of betaARR1 or betaARR2 inhibits NT-stimulated ERK1/2 and JNK phosphorylation, NF-kappaB p65 nuclear translocation and phosphorylation, and IL-8 secretion.	SM 19712	54-61	C-X-C motif chemokine ligand 8	Homo sapiens	220-224
22490085-7	2012	With sitosterol, campesterol, and 7-ketositosterol, IL-8 secretion was decreased, and with campesterol the intracellular polar lipid level was reduced.	gamma-sitosterol	5-15	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
22490085-7	2012	With sitosterol, campesterol, and 7-ketositosterol, IL-8 secretion was decreased, and with campesterol the intracellular polar lipid level was reduced.	campesterol	17-28	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
22490085-7	2012	With sitosterol, campesterol, and 7-ketositosterol, IL-8 secretion was decreased, and with campesterol the intracellular polar lipid level was reduced.	7-ketositosterol	34-50	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
22323305-14	2012	The LCI correlated with bronchoalveolar lavage IL-8 (R(2) = 0.20, P = 0.004) and neutrophil count (R(2) = 0.21, P = 0.001).	Casein Kinase inhibitor A86	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
22095388-9	2012	Cells pretreated with nicotine prior to lipopolysaccharide (LPS) stimulation exhibited a lower production of TNF-alpha, IL-8, and IL-6 compared to LPS-treated (only) cells.	Nicotine	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
22322153-7	2012	PFOA induced gene expression of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in mast cells.	perfluorooctanoic acid	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
22469443-6	2012	RESULTS: Serum levels of IL-8, MCP-1, and CCL-20 were significantly higher in the AS group than in the AR and NA groups.	Arsenic	82-84	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
22460142-7	2012	Tofacitinib reduced serum levels of human IL-6 and IL-8 in the mice and also reduced synovial inflammation and invasion into the implanted cartilage.	tofacitinib	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
22274300-0	2012	Modulatory effect of fenofibrate on endothelial production of neutrophil chemokines IL-8 and ENA-78.	Fenofibrate	21-32	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
22473315-0	2012	Lactate-induced IL-8 pathway in endothelial cells--letter.	Lactic Acid	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
22095388-10	2012	Cells that were transfected with alpha7 siRNA and subsequently incubated with nicotine and LPS, exhibited a higher expression of TNF-alpha, IL-8, and IL-6 compared with non-transfected cells or alpha1 and alpha5 siRNA-transfected cells.	Nicotine	78-86	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
22531917-0	2012	Prostaglandin E2 modulates IL-8 expression through formation of a multiprotein enhanceosome in human colonic epithelial cells.	Dinoprostone	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
22484638-11	2012	In vivo, IL-8 expression was non-significantly suppressed in the curcumin-supplemented patients compared to the squamous control tissue, whilst also showing a doubling in the apoptotic frequency compared to non-supplemented control patients.	Curcumin	65-73	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
22457139-0	2012	Effect of puerarin on the release of interleukin-8 in co-culture of human bronchial epithelial cells and neutrophils.	puerarin	10-18	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
22457139-7	2012	Treatment with puerarin could significantly down-regulate the expression of IL-8 mRNA in BEAS-2B cells and IL-8 release in the supernatant of the co-culture of BEAS-2B cells and neutrophils (P&lt;0.01).	puerarin	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
22457139-7	2012	Treatment with puerarin could significantly down-regulate the expression of IL-8 mRNA in BEAS-2B cells and IL-8 release in the supernatant of the co-culture of BEAS-2B cells and neutrophils (P&lt;0.01).	puerarin	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
22457139-8	2012	CONCLUSION: Puerarin could exhibit anti-inflammatory activity by suppressing IL-8 production from the co-culture of human bronchial epithelial cells and neutrophils.	puerarin	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
22045303-3	2012	The aim of this study was to evaluate the effects of one of the most widespread mycotoxin, ochratoxin A (OTA), on the release of pro-inflammatory cytokines such as interleukin-(IL)-6 and the CXC-chemokine IL-8 from nasal epithelial cell cultures (NEC) of subjects with and without ECRS.	ochratoxin A	91-103	C-X-C motif chemokine ligand 8	Homo sapiens	205-209
22531917-2	2012	PGE(2) binding and coupling through EP2/4 receptor subtypes on colonic epithelial cells stimulates cyclic adenosine monophosphate (cAMP) and IL-8 production.	Dinoprostone	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
22531917-3	2012	Here we determined the mechanisms whereby PGE(2) regu-lates IL-8 in Caco2 colonic epithelial cells and in cells over-expressing the EP2/4 receptors (EP2S/EP4S).	Prostaglandins E	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
22531917-7	2012	PGE(2) coupling through EP2/4 receptors can therefore acts in an opposing manner to either decrease (EP2) or promote IL-8 expression by recruiting CREB-binding protein (CBP) (EP4), which formed a multiprotein IL-8 enhanceosome.	Prostaglandins E	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
22531917-7	2012	PGE(2) coupling through EP2/4 receptors can therefore acts in an opposing manner to either decrease (EP2) or promote IL-8 expression by recruiting CREB-binding protein (CBP) (EP4), which formed a multiprotein IL-8 enhanceosome.	Prostaglandins E	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
22531917-9	2012	These data unravel the mechanisms by which expression of IL-8 is controlled by different signalling pathways that are activated by PGE(2) but acting through different EP receptors.	Dinoprostone	131-137	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
22366056-3	2012	Results showed that testosterone at pharmacological doses reduced the production of interleukin-8 and reactive oxygen species from differentiated HL-60 cells in a concentration dependent manner without affecting phagocytosis.	Testosterone	20-32	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
22105228-4	2012	(1) In human HCC cell lines (HCC-1.2, HCC-3, and SNU398) linoleic acid peroxide (LOOH) and other prooxidants enhanced the expression of VEGF and IL-8.	snu398	49-55	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
22105228-4	2012	(1) In human HCC cell lines (HCC-1.2, HCC-3, and SNU398) linoleic acid peroxide (LOOH) and other prooxidants enhanced the expression of VEGF and IL-8.	linoleic acid peroxide	57-79	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
22105228-4	2012	(1) In human HCC cell lines (HCC-1.2, HCC-3, and SNU398) linoleic acid peroxide (LOOH) and other prooxidants enhanced the expression of VEGF and IL-8.	Lipid Peroxides	81-85	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
22105228-13	2012	In contrast, selenium inversely correlated with VEGF, IL-8, and HCC size (the latter only for tumors smaller than 3 cm).	Selenium	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
22068339-6	2012	Se depletion decreased expression of glutathione peroxidase1 (GPX1) and selenoproteins H and W and increased TNFalpha-stimulated luciferase activity, endogenous IL-8 expression and reactive oxygen species (ROS) production.	Selenium	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
22487368-5	2012	Quercetin, one of the active components in Calendula, has been shown to inhibit recombinant human matrix metalloproteinase (MMP) activity and decrease the expression of tumor necrosis factor-alpha, interleukin-1beta (IL), IL-6 and IL-8 in phorbol 12-myristate 13-acetate and calcium ionophore-stimulated human mast cells.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	231-235
22366056-5	2012	At the highest concentration of testosterone (120 muM), interleukin-8 secretion was reduced 42-80%, and production of reactive oxygen species was reduced 32-46%.	Testosterone	32-44	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
22366056-9	2012	Testosterone, at pharmacological doses, was also shown to suppress generation of reactive oxygen species and interleukin-8 in human granulocytes and monocytes, respectively, to a similar extent as observed in differentiated HL-60 cells.	Testosterone	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	109-122
21479710-2	2012	(18)F sodium fluoride ((18)F NaF) positron emission tomography (PET)/computed tomography (CT) has better resolution and is considered superior.	Sodium Fluoride	6-21	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
22218461-9	2012	Tri-DAP and             MDP led to the production of IL-6 and IL-8 and the activation of NF-kappaB and MAPK             in PDL cells.	Acetylmuramyl-Alanyl-Isoglutamine	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
22357660-0	2012	Ribavirin regulates hepatitis C virus replication through enhancing interferon-stimulated genes and interleukin 8.	Ribavirin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	100-113
22357660-7	2012	RBV upregulated interleukin 8 (IL-8) in the absence of IFN-alpha.	Ribavirin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	16-29
22357660-7	2012	RBV upregulated interleukin 8 (IL-8) in the absence of IFN-alpha.	Ribavirin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
22357660-8	2012	The IL-8 upregulation induced by RBV was responsible for the activation of activator protein 1 (AP-1).	Ribavirin	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
22357660-10	2012	Moreover, RBV can enhance IL-8 through activating AP-1.	Ribavirin	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
21951103-0	2012	Melatonin suppresses acrolein-induced IL-8 production in human pulmonary fibroblasts.	Melatonin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
21951103-0	2012	Melatonin suppresses acrolein-induced IL-8 production in human pulmonary fibroblasts.	Acrolein	21-29	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
21951103-3	2012	Furthermore, recent studies show that, alpha, beta-unsaturated aldehyde acrolein in CS induces the production of interleukin (IL)-8, which is known to be related to bronchitis, rhinitis, pulmonary fibrosis, and asthma.	alpha, beta-unsaturated aldehyde acrolein	39-80	C-X-C motif chemokine ligand 8	Homo sapiens	113-131
21951103-3	2012	Furthermore, recent studies show that, alpha, beta-unsaturated aldehyde acrolein in CS induces the production of interleukin (IL)-8, which is known to be related to bronchitis, rhinitis, pulmonary fibrosis, and asthma.	Cesium	84-86	C-X-C motif chemokine ligand 8	Homo sapiens	113-131
21951103-6	2012	In this study, we investigated whether melatonin suppresses acrolein-induced IL-8 secretion in human pulmonary fibroblasts (HPFs).	Melatonin	39-48	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
21951103-6	2012	In this study, we investigated whether melatonin suppresses acrolein-induced IL-8 secretion in human pulmonary fibroblasts (HPFs).	Acrolein	60-68	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
21951103-7	2012	It was found that acrolein-induced IL-8 production was accompanied by increased levels of phosphorylation of Akt and extracellular signal-regulated kinases (ERK1/2) in HPFs, and that melatonin suppressed IL-8 production in HPFs.	Acrolein	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
21951103-7	2012	It was found that acrolein-induced IL-8 production was accompanied by increased levels of phosphorylation of Akt and extracellular signal-regulated kinases (ERK1/2) in HPFs, and that melatonin suppressed IL-8 production in HPFs.	Acrolein	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
21951103-7	2012	It was found that acrolein-induced IL-8 production was accompanied by increased levels of phosphorylation of Akt and extracellular signal-regulated kinases (ERK1/2) in HPFs, and that melatonin suppressed IL-8 production in HPFs.	Melatonin	183-192	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
21951103-8	2012	These results suggest that melatonin suppresses acrolein-induced IL-8 production via ERK1/2 and phosphatidylinositol 3-kinase (PI3K)/Akt signal inhibition in HPFs.	Melatonin	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
21951103-8	2012	These results suggest that melatonin suppresses acrolein-induced IL-8 production via ERK1/2 and phosphatidylinositol 3-kinase (PI3K)/Akt signal inhibition in HPFs.	Acrolein	48-56	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
22697068-4	2012	Indeed, differentiated THP-1 cell exposures (i) to 5 and 10 microM of combination of NP and DiP induced an IL-8 level in the medium respectively of 28.9 and 45 percent higher than the level obtained for the control (untreated cells), (ii) to combination of NP and DiP at 10 microM induced an increase of IL-1beta level in comparison to the control level, (iii) to combination of NP and DiP induced an increase of TNF-alpha level whatever the concentration of EDCs tested (between 0 and 10 microM).	diisononyl phthalate	92-95	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
22093110-5	2012	Pre-incubating HUVECs with NAC prevented the effects induced by 5.0 mM of NaF and 0.5 mM of Sn(2) F.	Acetylcysteine	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
22310660-4	2012	Consequently, induction of cytokines interleukin-8 and beta interferon after poly(I   C) stimulation was impaired in Rb(-/-) MEF and Rb siRNA-transfected cells compared to controls.	Poly I-C	77-88	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
21633399-8	2012	The oral glucose challenge was associated with a significant increase in the expression of inflammatory cytokines, including interleukin (IL)-1alpha/beta, IL-6, and IL-8, that may result from ER stress.	Glucose	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
22392142-0	2012	NADPH oxidase-derived superoxide destabilizes lipopolysaccharide-induced interleukin 8 mRNA via p38, extracellular signal-regulated kinase mitogen-activated protein kinase, and the destabilizing factor tristetraprolin.	Superoxides	22-32	C-X-C motif chemokine ligand 8	Homo sapiens	73-86
21748755-0	2012	Lenalidomide modulates IL-8 and anti-prostate antibody levels in men with biochemically recurrent prostate cancer.	Lenalidomide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
22408359-5	2012	RESULTS: The overexpression of IL-8 resulted in an increased cell adhesion, migration and invasion, and a significant resistance to oxaliplatin in MKN-45 cells.	Oxaliplatin	132-143	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
22452847-3	2012	Recently, we reported that the protein kinase A (PKA) inhibitor H-89 suppresses lipopolysaccharide (LPS)-induced IL-8 production by human gingival fibroblasts (HGFs).	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	64-68	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
22452847-4	2012	In the present study, the relevance of the PKA activity and two PKA-activating drugs, aminophylline and adrenaline, to LPS-induced inflammatory cytokines (IL-6 and IL-8) and PGE2 by HGFs were examined.	Aminophylline	86-99	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
22452847-4	2012	In the present study, the relevance of the PKA activity and two PKA-activating drugs, aminophylline and adrenaline, to LPS-induced inflammatory cytokines (IL-6 and IL-8) and PGE2 by HGFs were examined.	Epinephrine	104-114	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
22452847-8	2012	In contrast, dbcAMP significantly increased LPS-induced IL-6, IL-8, and PGE2 production.	Bucladesine	13-19	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
22227206-8	2012	HPAH PASMCs exhibited enhanced IL-6 and IL-8 induction by TGF-beta1, an effect reversed by NF-kappaB inhibition.	pasmcs	5-11	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
22227206-9	2012	Moreover, neutralizing antibodies to IL-6 or IL-8 restored the antiproliferative effect of TGF-beta1 in HPAH PASMCs.	pasmcs	109-115	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
22420994-0	2012	Involvement of metabotropic glutamate receptor 5, AKT/PI3K signaling and NF-kappaB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes.	Methamphetamine	94-109	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
22420994-10	2012	Also, LY294002, an inhibitor of the Akt/PI3K pathway, abrogated the MA-mediated induction of IL-6 and IL-8 by 77.9 +- 6.6% and 81.4 +- 2.6%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
22228760-8	2012	Pretreatment with a chemical chaperone, phenylbutyric acid, or adenoviral transfection with ATF6 attenuated HNE-induced monocyte adhesion and IL-8 induction.	4-phenylbutyric acid	40-58	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
22356100-6	2012	Caffeic acid at &lt;=20 muM demoted resistin-stimulated interleukin 8 (IL-8) production responsible for ICAM-1 and beta2 integrin induction.	caffeic acid	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
22356100-6	2012	Caffeic acid at &lt;=20 muM demoted resistin-stimulated interleukin 8 (IL-8) production responsible for ICAM-1 and beta2 integrin induction.	caffeic acid	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
22356100-7	2012	The endothelial up-regulation of IL-8 secretion by resistin entailed toll-like receptor 4 (TLR4) activation, but caffeic acid diminished IL-8 production and TLR4 induction.	caffeic acid	113-125	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
22356100-9	2012	These results demonstrate that caffeic acid blocked monocyte trafficking to resistin-activated endothelium via disturbing NF-kappaB signaling responsive to IL-8.	caffeic acid	31-43	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
22408359-6	2012	Inhibition of IL-8 expression with small interfering RNA decreased the adhesion, migration and invasion functions and oxaliplatin resistance in KATO-III cells.	Oxaliplatin	118-129	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
22410118-0	2012	1,3-Diphenylpropenone ameliorates TNBS-induced rat colitis through suppression of NF-kappaB activation and IL-8 induction.	Chalcones	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
22410118-0	2012	1,3-Diphenylpropenone ameliorates TNBS-induced rat colitis through suppression of NF-kappaB activation and IL-8 induction.	Trinitrobenzenesulfonic Acid	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
22285171-7	2012	Dexamethasone pretreatment prior to LPS exposure significantly decreased IL-6 and IL-8 levels in both cell lines.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
22410118-1	2012	In the present study, we examined whether newly synthesized phenylpropenone derivatives, by inhibiting NF-kappaB activity, would inhibit IL-8 expression, inflammation and abnormal angiogenesis, resulting in amelioration of disease conditions.	phenylpropenone	60-75	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
22410118-3	2012	Among the derivatives, 1,3-diphenylpropenone (DPhP) was most efficacious, and it significantly suppressed TNF-alpha-induced production of IL-8 which is a proinflammatory and proangiogenic cytokine.	Chalcones	23-44	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
22410118-3	2012	Among the derivatives, 1,3-diphenylpropenone (DPhP) was most efficacious, and it significantly suppressed TNF-alpha-induced production of IL-8 which is a proinflammatory and proangiogenic cytokine.	Chalcones	46-50	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
22410118-6	2012	In the colon tissue, DPhP inhibited TNBS-induced NF-kappaB nuclear translocation, IL-8 and TNF-alpha expressions, and abnormal angiogenesis.	Chalcones	21-25	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
22410118-6	2012	In the colon tissue, DPhP inhibited TNBS-induced NF-kappaB nuclear translocation, IL-8 and TNF-alpha expressions, and abnormal angiogenesis.	Trinitrobenzenesulfonic Acid	36-40	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
22410118-9	2012	In conclusion, the results suggest that DPhP is a potential dual-acting IBD drug candidate targeting both inflammation and abnormal angiogenesis, possibly through the NF-kappaB and IL-8 signaling pathway.	Chalcones	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
22289904-6	2012	RESULTS: Pretreatment with dexamethasone led to a significant decrease in myocardial expression of IL-6, IL-8, IL-1beta, and TNF-alpha messenger RNA and to a decrease in protein synthesis of TNF-alpha.	Dexamethasone	27-40	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
22565056-8	2012	In contrast, PGE(2) enhanced CXCL8 production early during maturation, whereas CXCL16 levels were continuously elevated, contributing to innate immune cell recruitment.	Dinoprostone	13-19	C-X-C motif chemokine ligand 8	Homo sapiens	29-34
21913898-8	2012	Roflumilast and roflumilast N-oxide concentration-dependently reduced the LPS-stimulated release of CCL2, CCL3, CCL4, CXCL10 and TNF-alpha from human lung macrophages, whereas that of CXCL1 or CXCL8 was not altered.	n-oxide	28-35	C-X-C motif chemokine ligand 8	Homo sapiens	193-198
22315307-8	2012	SkMCs released IL-6, IL-8, and monocyte chemoattractant protein-1 on Hsp60 stimulation.	skmcs	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
22189418-9	2012	These peptides similarly displaced the binding of (125)I-hCXCL8 to hCXCR1 (IC(50) ranging from 8.5 to 10muM) in a dose-dependent manner, inhibited hCXCL8 induced increases in the intracellular calcium, and migration of hCXCR1- and hCXCR2-transfected cells.	Calcium	193-200	C-X-C motif chemokine ligand 8	Homo sapiens	57-63
22189418-9	2012	These peptides similarly displaced the binding of (125)I-hCXCL8 to hCXCR1 (IC(50) ranging from 8.5 to 10muM) in a dose-dependent manner, inhibited hCXCL8 induced increases in the intracellular calcium, and migration of hCXCR1- and hCXCR2-transfected cells.	Calcium	193-200	C-X-C motif chemokine ligand 8	Homo sapiens	147-153
21848430-8	2012	We observed inhibition of cytokines (interleukin [IL]-1beta (beta), IL-6, IL-8, IL-10, and tumor necrosis factor-alpha) in the presence of azithromycin in EB-stimulated cells from both fertile and infertile women with primary and recurrent C. trachomatis infection.	Azithromycin	139-151	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
22116002-6	2012	Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
21885397-10	2012	Carbachol stimulated release of LTB(4) from lung macrophages (buffer 222.3 +- 75.1 versus carbachol 1,118 +- 622.4 pg   mL(-1); n = 15, p&lt;0.05) but not IL-6 or IL-8.	Carbachol	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
22116002-6	2012	Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
22116002-6	2012	Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1.	Zymosan	122-129	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
22116002-7	2012	LPS, poly(I:C), and zymosan thus each induced a distinct pattern of cytokine and chemokine release from human corneal fibroblasts, with the release of IL-6, IL-8, and MCP-1 being commonly elicited by all three agents.	Poly I-C	5-14	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
22116002-7	2012	LPS, poly(I:C), and zymosan thus each induced a distinct pattern of cytokine and chemokine release from human corneal fibroblasts, with the release of IL-6, IL-8, and MCP-1 being commonly elicited by all three agents.	Zymosan	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
22236730-9	2012	TNF-alpha (P &lt; .05) and IL-8 fold suppression by dexamethasone (P &lt; .05) were significantly reduced in PBMCs from SR asthmatic patients.	Dexamethasone	52-65	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
22379967-10	2012	Finally, 5,7-DMF reduced IkappaBalpha phosphorylation, blocked NF-kappaB p65 nuclear translocation, strongly suppressed proinflammatory cytokines such as interleukin-6 (IL-6) and IL-8.	5,7-dimethoxyflavone	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
22192353-0	2012	Peroxisome proliferating activating receptor gamma-independent attenuation of interleukin 6 and interleukin 8 secretion from primary endometrial stromal cells by thiazolidinediones.	Thiazolidinediones	162-180	C-X-C motif chemokine ligand 8	Homo sapiens	96-109
22192353-8	2012	RESULT(S): Treatment of stromal cells with thiazolidinediones attenuated IL-6 and IL-8 release in a dose-dependent manner.	Thiazolidinediones	43-61	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
22192353-11	2012	CONCLUSION(S): Thiazolidinediones decrease the proinflammatory cytokines IL-6 and IL-8 in endometrial stromal cells via a PPAR-gamma-independent mechanism.	Thiazolidinediones	15-33	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
22158745-5	2012	In contrast, coculture of A549 cells with the macrophage-like THP-1 cell line, differentiated with vitamin D, or monocyte-derived macrophages enhanced CXCL8 release.	Vitamin D	99-108	C-X-C motif chemokine ligand 8	Homo sapiens	151-156
21907687-11	2012	Lipid accumulation in hepatocytes, induced by incubation with fatty acids, was associated with increased CML formation and expression of the receptor for advanced glycation endproducts (RAGE), PAI-1, IL-8, IL-6, and CRP.	Fatty Acids	62-73	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
21545687-5	2012	Tumour necrosis factor-alpha (TNF-alpha) significantly induced phosphorylation of p38 MAPK, ERK, Akt and production of IL-8 from HCC cells, which were prevented by SB203580 (p38 MAPK inhibitor), PD98059 (ERK inhibitor), LY294002 and Wortmannin (PI3K inhibitor) and SB328437 (CCR3 inhibitor).	SB 203580	164-172	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
21545687-5	2012	Tumour necrosis factor-alpha (TNF-alpha) significantly induced phosphorylation of p38 MAPK, ERK, Akt and production of IL-8 from HCC cells, which were prevented by SB203580 (p38 MAPK inhibitor), PD98059 (ERK inhibitor), LY294002 and Wortmannin (PI3K inhibitor) and SB328437 (CCR3 inhibitor).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	195-202	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
21545687-5	2012	Tumour necrosis factor-alpha (TNF-alpha) significantly induced phosphorylation of p38 MAPK, ERK, Akt and production of IL-8 from HCC cells, which were prevented by SB203580 (p38 MAPK inhibitor), PD98059 (ERK inhibitor), LY294002 and Wortmannin (PI3K inhibitor) and SB328437 (CCR3 inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
21545687-5	2012	Tumour necrosis factor-alpha (TNF-alpha) significantly induced phosphorylation of p38 MAPK, ERK, Akt and production of IL-8 from HCC cells, which were prevented by SB203580 (p38 MAPK inhibitor), PD98059 (ERK inhibitor), LY294002 and Wortmannin (PI3K inhibitor) and SB328437 (CCR3 inhibitor).	Wortmannin	233-243	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
21545687-5	2012	Tumour necrosis factor-alpha (TNF-alpha) significantly induced phosphorylation of p38 MAPK, ERK, Akt and production of IL-8 from HCC cells, which were prevented by SB203580 (p38 MAPK inhibitor), PD98059 (ERK inhibitor), LY294002 and Wortmannin (PI3K inhibitor) and SB328437 (CCR3 inhibitor).	SB 328437	265-273	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
22325176-7	2012	In addition, DHMEQ inhibited IL-8 production induced by LPS in HT-29 cells.	dehydroxymethylepoxyquinomicin	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
21907687-12	2012	Pyridoxamine and aminoguanidine inhibited the endogenous CML formation and the increased RAGE, PAI-1, IL-8, IL-6, and CRP expression.	Pyridoxamine	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
21907687-12	2012	Pyridoxamine and aminoguanidine inhibited the endogenous CML formation and the increased RAGE, PAI-1, IL-8, IL-6, and CRP expression.	pimagedine	17-31	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
21698672-4	2012	An oily extract of ginger rhizome with &gt; 25% total pungent compounds, ginger volatile oil, ar-curcumene and alpha-pinene reduced the LPS-induced IL-8 secretion (measured by a specific enzyme-linked immunosorbent assay), whereas a spissum extract, the pungents [6]-gingerol and its metabolite [6]-shogaol, and the terpenoids citral and beta-phellandrene showed no effect.	alpha-curcumene	94-106	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
22309277-9	2012	CRSwNP cultures were more sensitive than controls to dexamethasone (1 microg/ml) dependent IL-6 and IL-8 suppression.	Dexamethasone	53-66	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
21698672-4	2012	An oily extract of ginger rhizome with &gt; 25% total pungent compounds, ginger volatile oil, ar-curcumene and alpha-pinene reduced the LPS-induced IL-8 secretion (measured by a specific enzyme-linked immunosorbent assay), whereas a spissum extract, the pungents [6]-gingerol and its metabolite [6]-shogaol, and the terpenoids citral and beta-phellandrene showed no effect.	alpha-pinene	111-123	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
21698672-4	2012	An oily extract of ginger rhizome with &gt; 25% total pungent compounds, ginger volatile oil, ar-curcumene and alpha-pinene reduced the LPS-induced IL-8 secretion (measured by a specific enzyme-linked immunosorbent assay), whereas a spissum extract, the pungents [6]-gingerol and its metabolite [6]-shogaol, and the terpenoids citral and beta-phellandrene showed no effect.	gingerol	267-275	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
21698672-4	2012	An oily extract of ginger rhizome with &gt; 25% total pungent compounds, ginger volatile oil, ar-curcumene and alpha-pinene reduced the LPS-induced IL-8 secretion (measured by a specific enzyme-linked immunosorbent assay), whereas a spissum extract, the pungents [6]-gingerol and its metabolite [6]-shogaol, and the terpenoids citral and beta-phellandrene showed no effect.	shogaol	295-306	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
21698672-4	2012	An oily extract of ginger rhizome with &gt; 25% total pungent compounds, ginger volatile oil, ar-curcumene and alpha-pinene reduced the LPS-induced IL-8 secretion (measured by a specific enzyme-linked immunosorbent assay), whereas a spissum extract, the pungents [6]-gingerol and its metabolite [6]-shogaol, and the terpenoids citral and beta-phellandrene showed no effect.	Terpenes	316-326	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
21698672-4	2012	An oily extract of ginger rhizome with &gt; 25% total pungent compounds, ginger volatile oil, ar-curcumene and alpha-pinene reduced the LPS-induced IL-8 secretion (measured by a specific enzyme-linked immunosorbent assay), whereas a spissum extract, the pungents [6]-gingerol and its metabolite [6]-shogaol, and the terpenoids citral and beta-phellandrene showed no effect.	citral	327-333	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
21698672-4	2012	An oily extract of ginger rhizome with &gt; 25% total pungent compounds, ginger volatile oil, ar-curcumene and alpha-pinene reduced the LPS-induced IL-8 secretion (measured by a specific enzyme-linked immunosorbent assay), whereas a spissum extract, the pungents [6]-gingerol and its metabolite [6]-shogaol, and the terpenoids citral and beta-phellandrene showed no effect.	beta-phellandrene	338-355	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
22611924-1	2012	OBJECTIVE: To investigate the effects of citreoviridin (CIT) on the expression of MCP-1, IL-1beta, IL-6 and IL-8 induced by TNF-alpha in human umbilical vein endothelial cells (HUVECs).	citreoviridin	41-54	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
21161531-0	2012	Inhibitors of p38 and ERK1/2 MAPkinase and hydrogen sulphide block constitutive and IL-1beta-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2.	Hydrogen Sulfide	43-60	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
21161531-6	2012	Furthermore, IL-6 and IL-8 expression was quantified by real-time polymerase chain reaction (RT-PCR) and ELISAs from cells which were exposed to SB203580, U0126 and NaHS and stimulated by IL-1beta.	SB 203580	145-153	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
21161531-6	2012	Furthermore, IL-6 and IL-8 expression was quantified by real-time polymerase chain reaction (RT-PCR) and ELISAs from cells which were exposed to SB203580, U0126 and NaHS and stimulated by IL-1beta.	U 0126	155-160	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
21161531-6	2012	Furthermore, IL-6 and IL-8 expression was quantified by real-time polymerase chain reaction (RT-PCR) and ELISAs from cells which were exposed to SB203580, U0126 and NaHS and stimulated by IL-1beta.	SODIUM HYDROSULFIDE	165-169	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
21161531-8	2012	The data provided prove that in these cells, constitutive as well as IL-1beta-induced IL-6 and IL-8 expression was partially and transiently blocked by the treatment of cells with both MAPK inhibitors and NaHS.	SODIUM HYDROSULFIDE	205-209	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
22611924-6	2012	CONCLUSION: The expression of NF-kappaB, MCP-1, IL-1beta, IL-6 and IL-8 in HUVECs up-regulated by TNF-alpha was promoted by CIT.	citreoviridin	124-127	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
22611924-1	2012	OBJECTIVE: To investigate the effects of citreoviridin (CIT) on the expression of MCP-1, IL-1beta, IL-6 and IL-8 induced by TNF-alpha in human umbilical vein endothelial cells (HUVECs).	citreoviridin	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
22271561-0	2012	The myxobacterial compounds spirangien a and spirangien M522 are potent inhibitors of IL-8 expression.	spirangien A	28-40	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
22800594-2	2012	METHODS: Nthy-ori 3-1 cells were exposed to 0.0, 0.1, 1.0, 3.0 mmol/L of sodium fluoride (NaF) in vitro.	Sodium Fluoride	73-88	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
22271561-0	2012	The myxobacterial compounds spirangien a and spirangien M522 are potent inhibitors of IL-8 expression.	spirangien M522	45-60	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
22074915-4	2012	We further show that blocking this channel perturbs the calcium homeostasis of the cells and inhibits the proliferation, production of VEGF, IL-8, and pro-MMP-2, and migration and invasion of RA-FLS.	Calcium	56-63	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
21917119-0	2012	Nonylphenol induces bronchial epithelial apoptosis via Fas-mediated pathway and stimulates bronchial epithelium to secrete IL-6 and IL-8, causing bronchial smooth muscle proliferation and migration.	nonylphenol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
22558684-0	2012	Effect of bamboo salt-NaF dentifrice on enamel remineralization.	bamboo salt	10-21	C-X-C motif chemokine ligand 8	Homo sapiens	22-25
21989538-12	2012	Conditioned media from AAT and SM cultures similarly upregulated IL-6, IL-8, Dickkopf-1 and osteoprotegerin production by rheumatoid FLS.	o-Aminoazotoluene	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
21969073-1	2012	We previously demonstrated in the human promyelocytic cell line THP-1 that all allergens tested, with the exception of the prohapten isoeugenol, induced a dose-related release of interleukin-8 (IL-8).	prohapten isoeugenol	123-143	C-X-C motif chemokine ligand 8	Homo sapiens	179-192
21969073-1	2012	We previously demonstrated in the human promyelocytic cell line THP-1 that all allergens tested, with the exception of the prohapten isoeugenol, induced a dose-related release of interleukin-8 (IL-8).	prohapten isoeugenol	123-143	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
21969073-7	2012	The increased expression of TTP in THP-1 cells treated with isoeugenol results in destabilization of the IL-8 mRNA, which can account for the lack of IL-8 release.	isoeugenol	60-70	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
21969073-8	2012	In contrast, the strong allergen DNCB failing to up-regulate TTP, while inducing HuR, resulted in longer IL-8 mRNA half-life and protein release.	Dinitrochlorobenzene	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
21969073-10	2012	Finally, the destabilization effect of isoeugenol on IL-8 mRNA expression together with SOCS-3 expression resulted in an anti-inflammatory effect, as demonstrated by the ability of isoeugenol to modulate LPS or ionomycin-induced cytokine release.	isoeugenol	39-49	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
21969073-10	2012	Finally, the destabilization effect of isoeugenol on IL-8 mRNA expression together with SOCS-3 expression resulted in an anti-inflammatory effect, as demonstrated by the ability of isoeugenol to modulate LPS or ionomycin-induced cytokine release.	Ionomycin	211-220	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
22231588-3	2012	We used isothermal titration calorimetry to measure the enthalpies of mixing, DeltaH(mix), of 3,3- and 6,6-ionene fluorides and bromides with low molecular weight salts (NaF, NaCl, NaBr, and NaI) at 298 K in water.	Bromides	128-136	C-X-C motif chemokine ligand 8	Homo sapiens	170-173
21917119-7	2012	Exposure of BEAS-2B and HBE to NP caused epithelial cells to produce inflammatory cytokines IL-6 and IL-8, which subsequently induced BSMC proliferation and migration.	bsmc	134-138	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
21917119-8	2012	Depleting both IL-6 and IL-8 completely reversed the effect of NP-BEAS-2B-CM- and NP-HBE-CM-mediated BSMC proliferation and migration, suggesting that this effect is a synergistic influence of IL-6 and IL-8.	bsmc	101-105	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
21917119-9	2012	This study is the first to demonstrate that NP not only induces bronchial epithelial apoptosis via the Fas-mediated pathway but also stimulates the bronchial epithelium to secrete IL-6 and IL-8, which cause bronchial smooth muscle proliferation and migration - major features in asthma remodelling.	nonylphenol	44-46	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
22316209-7	2012	We examined the gene expression profile of two lung tumor cell lines to identify a shared gene signature in response to sublethal cisplatin/vinorelbine and found coordinate expression of only 16 transcripts, including those for cytokine/chemokine expression and apoptosis such as tumor necrosis factor-alpha, IL8, CXCL5, and B cell lymphoma-2-like genes (BCL-2).	Cisplatin	130-139	C-X-C motif chemokine ligand 8	Homo sapiens	309-312
22490477-12	2012	Sufentanil consumption and plasma interleukin-8 levels at 2 and 12 hours postoperatively were significantly lower in the PA group than the C group (P &lt; 0.05).	Protactinium	121-123	C-X-C motif chemokine ligand 8	Homo sapiens	34-47
21347606-9	2012	Dopamine doses were positively associated with IL-6, and norepinephrine was inversely associated with IL-8 and TNF-alpha levels.	Norepinephrine	57-71	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
21997482-8	2012	Catalase overexpression and inhibitors of mitochondrial respiration diminished elevations in IL-8 and COX-2 induced by exposure to 1,2-NQ, but potentiated HO-1 mRNA levels in BEAS cells.	1,2-naphthoquinone	131-137	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
21828034-3	2012	We investigated whether interleukin (IL)-17A induces GC insensitivity in airway epithelium by studying its effects on responsiveness of tumour necrosis factor (TNF)-alpha-induced IL-8 production to budesonide in human bronchial epithelial 16HBE cells.	Budesonide	198-208	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
21828034-5	2012	We demonstrated that IL-17A-induced IL-8 production is normally sensitive to GCs, while IL-17A pre-treatment significantly reduced the sensitivity of TNF-alpha-induced IL-8 production to budesonide.	Budesonide	187-197	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
21487907-5	2012	IL-8 levels were significantly higher in patients with pulmonary edema (1,829 +- 2,496 vs 456 +- 624 pg/ml, p &lt; 0.05); sIL-2r, IL-6, and IL-8 levels were increased proportionally to Killip class (r = 0.35, p &lt; 0.05; r = 0.48, r = 0.47, p &lt; 0.01) and in patients with LV ejection fraction (LVEF) &lt; 30%.	killip	185-191	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
21088047-11	2012	Inhibition of lipolysis by orlistat or CAY10499 reduced LPS-induced IL-6 and IL-8 mRNA expression.	CAY 10499	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
22094458-0	2012	An NF-kappaB-independent and Erk1/2-dependent mechanism controls CXCL8/IL-8 responses of airway epithelial cells to cadmium.	Cadmium	116-123	C-X-C motif chemokine ligand 8	Homo sapiens	65-70
22221101-0	2012	Transient receptor potential vanilloid-1 participates in the inhibitory effect of ginsenoside Rg1 on capsaicin-induced interleukin-8 and prostaglandin E2 production in HaCaT cells.	Capsaicin	101-110	C-X-C motif chemokine ligand 8	Homo sapiens	119-132
22221101-8	2012	More importantly, GRg1 dose-dependently inhibited capsaicin-induced PGE(2) and IL-8 secretion in HaCaT cells and HEK 293T-TRPV1 cells.	Capsaicin	50-59	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
21809384-4	2012	Effects of short-term treatment with IL-alpha, IL-6, or IL-8 on endogenous GTP-bound Cdc42 levels were assessed using an affinity assay, and on actin filament organization using confocal microscopy.	Guanosine Triphosphate	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
21809384-6	2012	Short exposure to IL-1alpha, IL-6, or IL-8 decreased endogenous GTP-Cdc42 and increased stress fibers, which were reversed with cytochalasin D treatment.	Guanosine Triphosphate	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
21809384-6	2012	Short exposure to IL-1alpha, IL-6, or IL-8 decreased endogenous GTP-Cdc42 and increased stress fibers, which were reversed with cytochalasin D treatment.	Cytochalasin D	128-142	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
22239529-5	2012	Results revealed that while thalidomide reduced IL-8 and nuclear factor kappa B (NF-kappaB) activity by 95% and 46% in Huh-7 cells, increasing concentrations of thalidomide correlated with a linear rise in HCV replication (17-fold at 200 mum).	Thalidomide	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
21998275-7	2012	Similar differences on MAPK activation and IL-8 cytokine release were also observed upon exposure of HEK293 cell transfectants expressing the A471V variants to Zymosan, a beta-glucan-rich fungal particle.	Zymosan	160-167	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
22048642-0	2012	The role of MAPK and Nrf2 pathways in ketanserin-elicited attenuation of cigarette smoke-induced IL-8 production in human bronchial epithelial cells.	Ketanserin	38-48	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
22048642-4	2012	In this study, we investigated the antioxidative and anti-inflammatory properties of ketanserin and its underlying mechanism of action on cigarette smoke-induced interleukin (IL)-8 release in vitro.	Ketanserin	85-95	C-X-C motif chemokine ligand 8	Homo sapiens	162-180
22048642-10	2012	Ketanserin suppressed CSM-induced IL-8 release by inhibiting p38, ERK1/2 MAPK, and Nrf2 signaling pathways and partially inhibited CSM-induced reduction of rGSH/GSSG ratio.	Ketanserin	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
22094458-0	2012	An NF-kappaB-independent and Erk1/2-dependent mechanism controls CXCL8/IL-8 responses of airway epithelial cells to cadmium.	Cadmium	116-123	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
22048642-7	2012	Consistently, CSM-induced IL-8 release was blocked by SB203580, U0126, or MEK1 small interfering RNA (siRNA) but not SP600125.	SB 203580	54-62	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
22048642-7	2012	Consistently, CSM-induced IL-8 release was blocked by SB203580, U0126, or MEK1 small interfering RNA (siRNA) but not SP600125.	U 0126	64-69	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
22094458-3	2012	To address the role of airway epithelial cells in cadmium-induced lung inflammation, we investigated how cadmium regulates secretion of interleukin 8 (IL-8) by airway epithelial cells.	Cadmium	105-112	C-X-C motif chemokine ligand 8	Homo sapiens	136-149
22094458-3	2012	To address the role of airway epithelial cells in cadmium-induced lung inflammation, we investigated how cadmium regulates secretion of interleukin 8 (IL-8) by airway epithelial cells.	Cadmium	105-112	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
22094458-4	2012	We show that exposure of human airway epithelial cells to subtoxic doses of cadmium in vitro promotes a characteristic inflammatory cytokine response consisting of IL-8, but not IL-1beta or tumor necrosis factor-alpha.	Cadmium	76-83	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
22094458-9	2012	However, only pharmacological inhibition of Erk1/2 pathway or knockdown of the expression of Erk1 and Erk2 using small interfering RNAs suppressed secretion of IL-8 induced by cadmium.	Cadmium	176-183	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
22094458-10	2012	Our findings identify cadmium as a potent activator of the proinflammatory cytokine IL-8 in lung epithelial cells and reveal for the first time the role of an NF-kappaB-independent but Erk1/2-dependent pathway in cadmium-induced lung inflammation.	Cadmium	22-29	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
22251280-1	2012	The interaction between nuclear graphite and molten fluoride salts (46.5 mol % LiF/11.5 mol % NaF/42 mol % KF) is investigated by synchrotron X-ray diffraction and C K-edge X-ray absorption near-edge structure (XANES).	Graphite	32-40	C-X-C motif chemokine ligand 8	Homo sapiens	94-97
22015639-10	2012	H(2)S-induced expression of IL-6, IL-8 and COX-2 was completely blocked by specific inhibitors of p38 and ERK1/2 MAPK and NF-kappaB.	Hydrogen Sulfide	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
26448690-6	2012	Like dexamethasone RU24858 also reduced CXCL8 and MIP-1alpha.	RU24858	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	40-45
26448690-8	2012	We have shown here that dexamethasone and RU24858 both increase Grb-2, BLT1 and Annexin-1 expression and inhibit CXCL8 and MIP-1alpha production.	Dexamethasone	24-37	C-X-C motif chemokine ligand 8	Homo sapiens	113-118
26448690-8	2012	We have shown here that dexamethasone and RU24858 both increase Grb-2, BLT1 and Annexin-1 expression and inhibit CXCL8 and MIP-1alpha production.	RU24858	42-49	C-X-C motif chemokine ligand 8	Homo sapiens	113-118
22251280-1	2012	The interaction between nuclear graphite and molten fluoride salts (46.5 mol % LiF/11.5 mol % NaF/42 mol % KF) is investigated by synchrotron X-ray diffraction and C K-edge X-ray absorption near-edge structure (XANES).	Fluorides	52-66	C-X-C motif chemokine ligand 8	Homo sapiens	94-97
22269218-8	2012	CONCLUSIONS: Gamma tocopherol supplementation increased IL-6, IL-8, and KDR mRNA abundances and suppressed sFlt1 and TNFalpha mRNA abundances thereby increased VEGF mRNA expression and angiogenesis in placental vascular network during late gestation.	Tocopherols	19-29	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
22269218-9	2012	It is plausible that the angiogenic effect of gamma tocopherol in placental vascular network is exerted via an alternate path by enhancing IL-6 and IL-8.	gamma-Tocopherol	46-62	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
22080750-0	2012	Prostaglandin E2 enhances interleukin-8 production via EP4 receptor in human pulmonary microvascular endothelial cells.	Dinoprostone	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	26-39
22080750-2	2012	This study investigated whether PGE(2) can induce production of interleukin (IL)-8, the major chemokine for neutrophil activation, from human pulmonary microvascular endothelial cells (HPMVECs).	Prostaglandins E	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	64-82
22080750-3	2012	PGE(2) significantly enhanced IL-8 protein production with increases in IL-8 mRNA expression and intracellular cAMP levels.	Prostaglandins E	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
22080750-3	2012	PGE(2) significantly enhanced IL-8 protein production with increases in IL-8 mRNA expression and intracellular cAMP levels.	Prostaglandins E	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
22080750-7	2012	PGE(2)-induced IL-8 production was accompanied by p38 phosphorylation and was significantly inhibited by a p38 inhibitor, SB-203580, but not by an ERK1/2 inhibitor, U-0126, or a JNK inhibitor, SP-600125.	Dinoprostone	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
22080750-7	2012	PGE(2)-induced IL-8 production was accompanied by p38 phosphorylation and was significantly inhibited by a p38 inhibitor, SB-203580, but not by an ERK1/2 inhibitor, U-0126, or a JNK inhibitor, SP-600125.	SB 203580	122-131	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
22080750-7	2012	PGE(2)-induced IL-8 production was accompanied by p38 phosphorylation and was significantly inhibited by a p38 inhibitor, SB-203580, but not by an ERK1/2 inhibitor, U-0126, or a JNK inhibitor, SP-600125.	pyrazolanthrone	193-202	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
22080750-9	2012	In conclusion, PGE(2) enhances IL-8 production via EP4 receptor coupled to G(s) protein in HPMVECs.	Prostaglandins E	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
22080750-11	2012	Because neutrophils play a critical role in the inflammation of acute lung injury/acute respiratory distress syndrome, IL-8 released from the pulmonary microvasculature in response to PGE(2) may contribute to pathophysiology of this disease.	Prostaglandins E	184-187	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
22020518-5	2012	Moreover, the spaCBA mutant induces an elevated level of interleukin-8 (IL-8) mRNA in Caco-2 cells compared to the wild type, possibly involving an interaction of lipoteichoic acid with Toll-like receptor 2.	lipoteichoic acid	163-180	C-X-C motif chemokine ligand 8	Homo sapiens	57-70
22230722-2	2012	It was the aim of this clinical study to assess the fluoride content, provided by NaF compared to amine fluoride, in saliva and plaque.	Fluorides	52-60	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
23227796-6	2012	In addition, AMC decreased gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8 in human mast cells.	7-amino-4-methylcoumarin	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	152-156
22239975-4	2012	In this study we show in human PBMCs that LPS stimulated proinflammatory cytokine release (CXCL8 and IL6) was inhibited by approximately 50% by the broad specificity phosphatidylinositol 3-kinase (PI3K) inhibitor, wortmannin.	Wortmannin	214-224	C-X-C motif chemokine ligand 8	Homo sapiens	91-96
22142850-3	2012	Here we show that exposure of human airway epithelial cells to cadmium promotes a polarized apical secretion of IL-6 and IL-8, two pivotal pro-inflammatory cytokines known to play an important role in pulmonary inflammation.	Cadmium	63-70	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
22142850-4	2012	We also determined that two distinct pathways controlled secretion of these proinflammatory cytokines by human airway epithelial cells as cadmium-induced IL-6 secretion occurs via an NF-kappaB dependent pathway, whereas IL-8 secretion involves the Erk1/2 signaling pathway.	Cadmium	138-145	C-X-C motif chemokine ligand 8	Homo sapiens	220-224
22142850-5	2012	Interestingly, the natural antioxidant curcumin could prevent both cadmium-induced IL-6 and IL-8 secretion by human airway epithelial cells.	Curcumin	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
22142850-5	2012	Interestingly, the natural antioxidant curcumin could prevent both cadmium-induced IL-6 and IL-8 secretion by human airway epithelial cells.	Cadmium	67-74	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
23383400-4	2012	At baseline, PBMCs of four sALS patients (Group 1) showed significantly increased expression of TLR2 and CD14; ALOX5, PTGS2 and MMP1; IL1alpha, IL1beta, IL6, IL36G, IL8 and TNF; CCL3, CCL20, CXCL2, CXCL3 and CXCL5.	sals	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	165-168
21714724-7	2012	INNOVATION: Our observation in this study reveals that flagellin-induced hydrogen peroxide (H(2)O(2)) generation is critical for TLR5-dependent innate immune responses, including IL-8 production and MUC5AC expression in the nasal epithelium.	Hydrogen Peroxide	73-90	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
22020518-5	2012	Moreover, the spaCBA mutant induces an elevated level of interleukin-8 (IL-8) mRNA in Caco-2 cells compared to the wild type, possibly involving an interaction of lipoteichoic acid with Toll-like receptor 2.	lipoteichoic acid	163-180	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
21818627-7	2012	Akt and NF-kappaB related inflammatory cytokine IL-1alpha, and IL-6 and the chemokine IL-8 were upregulated in treated cells at 6 and 24 h. The calpain inhibitor leupeptin limited Akt phosphorylation to Ser(473) and reduced release of IL-1alpha, IL-6, and IL-8, indicating that calpain or similar protease(s) are involved in PM-induced activation of Akt and subsequent release of inflammatory cytokines.	leupeptin	162-171	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
21818627-7	2012	Akt and NF-kappaB related inflammatory cytokine IL-1alpha, and IL-6 and the chemokine IL-8 were upregulated in treated cells at 6 and 24 h. The calpain inhibitor leupeptin limited Akt phosphorylation to Ser(473) and reduced release of IL-1alpha, IL-6, and IL-8, indicating that calpain or similar protease(s) are involved in PM-induced activation of Akt and subsequent release of inflammatory cytokines.	leupeptin	162-171	C-X-C motif chemokine ligand 8	Homo sapiens	256-260
22020518-6	2012	In contrast, an L. rhamnosus GG mutant without exopolysaccharides but with an increased exposure of pili leads to the reduced expression of IL-8.	exopolysaccharides	47-65	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
22020518-8	2012	Taken together, our data suggest that L. rhamnosus GG SpaCBA pili, while promoting strong adhesive interactions with IECs, have a functional role in balancing IL-8 mRNA expression induced by surface molecules such as lipoteichoic acid.	lipoteichoic acid	217-234	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
22086137-9	2012	Our results show that high glucose concentrations (12 mM and particularly 24 mM) alter the biomineralization process in osteoblastic cells and provoke the following: i) a rise in mineralization, ii) an increase in the mRNA expression of RANKL and a decrease of OPG, iii) an increase in the mRNA expression of osteocalcin, bone sialoprotein and the transcription factor Runx2, iv) a diminished quality of the mineral, and v) an increase in the expression of IL1beta, IL6, IL8, MCP-1 and IL10 mRNAs.	Glucose	27-34	C-X-C motif chemokine ligand 8	Homo sapiens	471-474
21835900-8	2012	Treatment with methylprednisolone, compared with placebo, was associated with a statistically significant reduction in plasma IL-6 and IL-8, a significant increase in plasma IL-10, and a significant reduction in postoperative IL-1ra and IL-6, but not IL-8 in BAL fluid obtained 1 day after surgery.	Methylprednisolone	15-33	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
23306224-2	2012	This study evaluated the surface of commercially pure titanium (cpTi) after exposure to different concentrations of sodium fluoride (NaF).	Titanium	54-62	C-X-C motif chemokine ligand 8	Homo sapiens	133-136
23306224-2	2012	This study evaluated the surface of commercially pure titanium (cpTi) after exposure to different concentrations of sodium fluoride (NaF).	Sodium Fluoride	116-131	C-X-C motif chemokine ligand 8	Homo sapiens	133-136
23306224-3	2012	The hypothesis tested in this study was that different concentrations of NaF applied at different time intervals can affect the titanium surface in different ways.	Titanium	128-136	C-X-C motif chemokine ligand 8	Homo sapiens	73-76
23306224-11	2012	SEM micrographs showed that the titanium surface exposed to NaF presented corrosion that varied with the different concentrations.	Titanium	32-40	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
21835900-8	2012	Treatment with methylprednisolone, compared with placebo, was associated with a statistically significant reduction in plasma IL-6 and IL-8, a significant increase in plasma IL-10, and a significant reduction in postoperative IL-1ra and IL-6, but not IL-8 in BAL fluid obtained 1 day after surgery.	Methylprednisolone	15-33	C-X-C motif chemokine ligand 8	Homo sapiens	251-255
22629114-9	2012	Together with LPS, adding gelatin tannate at different concentrations induced a dose-dependent inhibition of IL-8 and TNF-alpha released by Caco-2 cells.	gelatin tannate	26-41	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
23113413-4	2012	Concentrations of IL-1beta, IL-6 and IL-8 related to creatinine levels (pg/micromol) were determined in urine samples in all.	Creatinine	53-63	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
23113413-8	2012	However, IL-8/creatinine levels were almost significant higher in case group (median 3.5 pg/micromol; SD 9.2) than in control group (median 1.54 pg/micromol; SD 3) (P=0.001).	Creatinine	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
23113413-10	2012	CONCLUSIONS: Urinary levels of IL-8/creatinine are elevated in children with vesicoureteral reflux, even in absence of urinary tract infection.	Creatinine	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
22132892-7	2012	The findings showed a high responsiveness of monocytes through CCL2/CXCL8 expression, contributing to the creation of a proinflammatory environment in CIU.	n-cyclohexyl-n'-(4-iodophenyl)urea	151-154	C-X-C motif chemokine ligand 8	Homo sapiens	68-73
22785256-7	2012	The release of interleukin (IL)-8 and tumor necrosis factor (TNF) alpha from THP-1 cells was significantly increased by the treatment of AMD or DEA with CYP3A4.	desethylamiodarone	144-147	C-X-C motif chemokine ligand 8	Homo sapiens	15-33
22387484-8	2012	CONCLUSIONS: We conclude that the NO-donor FK-409 improves the microcirculation by increasing the deformability of IL-8 activated PMN.	FK 409	43-49	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
22675954-6	2012	The increase in IL-8 production by IL-1alpha or TNF-alpha was further enhanced by simultaneous addition of C2-ceramide.	N-acetylsphingosine	107-118	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
22675954-7	2012	The increase of IL-8 stimulated by IL-1alpha or TNF-alpha was also suppressed by treatment with U0126 or SB203580.	U 0126	96-101	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
22675954-7	2012	The increase of IL-8 stimulated by IL-1alpha or TNF-alpha was also suppressed by treatment with U0126 or SB203580.	SB 203580	105-113	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
22675954-8	2012	The results of this study demonstrate that the production of IL-8 induced by IL-1alpha and TNF-alpha is enhanced by C2-ceramide, and suppressed by MEK inhibitor or P38 MAP kinase inhibitor.	N-acetylsphingosine	116-127	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
22785256-8	2012	Similarly, IL-8 and TNFalpha were also upregulated by the treatment of AMD and DEA with human liver microsomes, but were inhibited by adding ketoconazole to the cell culture.	Ketoconazole	141-153	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
22152986-0	2012	N-Aryl-2-phenyl-2,3-dihydro-imidazo[1,2-b]pyrazole-1-carboxamides 7-substituted strongly inhibiting both fMLP-OMe- and IL-8-induced human neutrophil chemotaxis.	n-aryl-2-phenyl-2,3-dihydro-imidazo[1,2-b]pyrazole-1-carboxamides	0-65	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
22186417-9	2012	Cotreatment with LPS and sodium propionate decreased LPS-induced expression of inflammatory genes including IL-6, IL-8, cyclooxygenase-2, IL-1alpha, intercellular adhesion molecule-1, and platelet endothelial cell adhesion molecule-1 but not IL-1beta or lymphocyte function-associated antigen-1.	sodium propionate	25-42	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
22186417-10	2012	Sodium propionate reduced LPS-induced neutrophil chemotaxis and protein secretion of the neutrophil chemoattractant IL-8.	sodium propionate	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
22723766-6	2012	The maximal inhibition of H(2)O(2)-induced IL-8 secretion was greater with 2000 microg mL(-1) of pWPI (50%) vs. nWPI (30%) hydrolysates.	Hydrogen Peroxide	26-34	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
23049614-9	2012	At the molecular level, acacetin significantly reduced IL-6, IL-8, intercellular adhesion molecule-1, and eotaxin-1 in activated BEAS-2B cells.	acacetin	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
22082188-0	2012	Oligodeoxynucleotides inhibit Toll-like receptor 3 mediated cytotoxicity and CXCL8 release in keratinocytes.	Oligodeoxyribonucleotides	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	77-82
22723766-6	2012	The maximal inhibition of H(2)O(2)-induced IL-8 secretion was greater with 2000 microg mL(-1) of pWPI (50%) vs. nWPI (30%) hydrolysates.	pwpi	97-101	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
22154580-7	2012	Risperidone increased the production of IL-10 and MDC as well as the proinflammatory cytokines, such as IL-6, IL-8, and TNF-alpha, but decreased the production of IP-10 and IL-12.	Risperidone	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
22414682-5	2012	RESULTS: The levels of IL-8 and GRO-alpha were significantly increased after treatment with EGF, TGF-alpha, TNF-alpha and TPA by primary cultured granulosa-lutein cells.	Tetradecanoylphorbol Acetate	122-125	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
22032841-9	2012	Dexamethasone had less suppressive effect on TNFalpha and CXCL8 production in vitro by neutrophils from induced sputum compared to neutrophils from paired blood samples.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	58-63
22132000-4	2012	We performed a genetic association study between IL8-251 (rs4073) and IL1B-511 (rs16944) polymorphisms in AERD, aspirin-tolerant asthma (ATA), and healthy control subjects.	Aspirin	112-119	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
22792109-3	2012	This study compared the effectiveness of GaAlAs diode laser alone and with topical sodium fluoride gel (NaF).	Sodium Fluoride	83-98	C-X-C motif chemokine ligand 8	Homo sapiens	104-107
22919389-6	2012	The positive control solution (saturated hydroxyapatite solution) and 4500 mg/L fluoride as NaF significantly increased nanohardness D1-T by 19.9% and 24.1%, respectively, whereas 1400 mg/L fluoride as NaF, casein phosphopeptide-amorphous calcium phosphate mousse and negative control (deionised water) had no significant effect.	Fluorides	80-88	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
22919389-6	2012	The positive control solution (saturated hydroxyapatite solution) and 4500 mg/L fluoride as NaF significantly increased nanohardness D1-T by 19.9% and 24.1%, respectively, whereas 1400 mg/L fluoride as NaF, casein phosphopeptide-amorphous calcium phosphate mousse and negative control (deionised water) had no significant effect.	Fluorides	80-88	C-X-C motif chemokine ligand 8	Homo sapiens	202-205
22919389-6	2012	The positive control solution (saturated hydroxyapatite solution) and 4500 mg/L fluoride as NaF significantly increased nanohardness D1-T by 19.9% and 24.1%, respectively, whereas 1400 mg/L fluoride as NaF, casein phosphopeptide-amorphous calcium phosphate mousse and negative control (deionised water) had no significant effect.	Fluorides	190-198	C-X-C motif chemokine ligand 8	Homo sapiens	202-205
22919389-6	2012	The positive control solution (saturated hydroxyapatite solution) and 4500 mg/L fluoride as NaF significantly increased nanohardness D1-T by 19.9% and 24.1%, respectively, whereas 1400 mg/L fluoride as NaF, casein phosphopeptide-amorphous calcium phosphate mousse and negative control (deionised water) had no significant effect.	calcium phosphate	239-256	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
22919389-6	2012	The positive control solution (saturated hydroxyapatite solution) and 4500 mg/L fluoride as NaF significantly increased nanohardness D1-T by 19.9% and 24.1%, respectively, whereas 1400 mg/L fluoride as NaF, casein phosphopeptide-amorphous calcium phosphate mousse and negative control (deionised water) had no significant effect.	Water	296-301	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
22837805-5	2012	RESULTS: KPV and gammaMSH evoked a dose-dependent inhibition of NFkappaB, matrix metalloproteinase-9 activity, IL8 and eotaxin secretion.	5-Phenyl-2-Keto-Valeric Acid	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	111-114
22627375-4	2012	We have observed that in the absence of eosinophil chemoattractants, neutrophils stimulated by IL-8 augment eosinophil trans-basement membrane migration by releasing superoxide anion, matrix metalloproteinase, leukotriene B(4) and platelet-activating factor.	Superoxides	166-182	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
22627375-4	2012	We have observed that in the absence of eosinophil chemoattractants, neutrophils stimulated by IL-8 augment eosinophil trans-basement membrane migration by releasing superoxide anion, matrix metalloproteinase, leukotriene B(4) and platelet-activating factor.	Leukotriene B4	210-223	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
21971406-5	2012	At baseline, increased hi-PA in normals predicted lower CSF levels of tau (r = -0.54, p = 0.020) and IL-8 (r = -0.70, p = 0.025).	hi-pa	23-28	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
21691053-8	2012	Endosomal TLR3 inhibition by chloroquine dose-dependently inhibited dsRNA-induced TSLP generation and reduced generation of CXCL8, TNF-alpha, and IFN-beta.	Chloroquine	29-40	C-X-C motif chemokine ligand 8	Homo sapiens	124-129
22102722-3	2012	In this study, we found that MSU crystals, through P2Y(6) receptors, stimulated normal human keratinocytes (NHK) to produce IL-1alpha, IL-8/CXCL8, and IL-6.	Uric Acid	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
22102722-3	2012	In this study, we found that MSU crystals, through P2Y(6) receptors, stimulated normal human keratinocytes (NHK) to produce IL-1alpha, IL-8/CXCL8, and IL-6.	Uric Acid	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	140-145
22102722-5	2012	Both P2Y(6)-specific antagonist and P2Y(6) antisense oligonucleotides significantly inhibited the production of IL-1alpha, IL-8/CXCL8, and IL-6 by NHK.	Oligonucleotides	53-69	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
22102722-5	2012	Both P2Y(6)-specific antagonist and P2Y(6) antisense oligonucleotides significantly inhibited the production of IL-1alpha, IL-8/CXCL8, and IL-6 by NHK.	Oligonucleotides	53-69	C-X-C motif chemokine ligand 8	Homo sapiens	128-133
21412767-5	2012	EGF-stimulated IL-8 production, phosphorylation of Akt and Erk, and cell proliferation and movement could be inhibited by EGFR inhibitor (Erlotinib), PI3K inhibitor (GDC-0941 BEZ-235 and SHBM1009), and ERK1/2 inhibitor (PD98059).	Erlotinib Hydrochloride	138-147	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
21753779-6	2012	Tumor necrosis factor-alpha- and benzo(a)pyrene (BaP)-induced reactive oxidative species (ROS) and IL-8 production were effectively inhibited by KCZ.	Benzo(a)pyrene	33-47	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
21753779-6	2012	Tumor necrosis factor-alpha- and benzo(a)pyrene (BaP)-induced reactive oxidative species (ROS) and IL-8 production were effectively inhibited by KCZ.	Benzo(a)pyrene	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
21753779-6	2012	Tumor necrosis factor-alpha- and benzo(a)pyrene (BaP)-induced reactive oxidative species (ROS) and IL-8 production were effectively inhibited by KCZ.	Ketoconazole	145-148	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
23206461-9	2012	CONCLUSIONS: Preincisional parecoxib administration reduced postoperative pain and morphine consumption compared with postincisional administration, and attenuated IL-6 and IL-8 production 24 h after hip replacement surgery.	parecoxib	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
22906259-0	2012	Wortmannin reduces metastasis and angiogenesis of human breast cancer cells via nuclear factor-kappaB-dependent matrix metalloproteinase-9 and interleukin-8 pathways.	Wortmannin	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	143-156
22906259-1	2012	OBJECTIVE: To investigate whether inhibition of Akt phosphorylation by the phosphatidylinositol 3-kinase (PI3K) inhibitor, wortmannin, reduces metastasis and angiogenesis in a human breast cancer cell line via nuclear factor (NF)-kappaB-dependent matrix metalloproteinase (MMP)-9 and interleukin (IL)-8 pathways.	Wortmannin	123-133	C-X-C motif chemokine ligand 8	Homo sapiens	284-302
22988345-7	2012	TNF-alpha treatment of IECs resulted in an association between EGFR and HER2 and inhibition of HER2 using a specific inhibitor AG879 in combination with AG1478-suppressed TNF-alpha-dependent ERK phosphorylation and IL-8 release.	AG-879	127-132	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
22906259-6	2012	RESULTS: Wortmannin inhibited the phosphorylation of Akt, upregulation of NF-kappaB, MMP-9, IL-8, and in vitro cell invasion and angiogenesis, in a dose-dependent manner.	Wortmannin	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
22906259-9	2012	CONCLUSION: The findings of the present study suggest that wortmannin inhibits metastasis and angiogenesis in breast cancer cells via PI3K/Akt/NF-kappaB-mediated MMP-9 and IL-8 signalling pathways.	Wortmannin	59-69	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
22363103-0	2012	Low dose theophylline showed an inhibitory effect on the production of IL-6 and IL-8 in primary lung fibroblast from patients with COPD.	Theophylline	9-21	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
22363103-6	2012	For COPD fibroblasts, the protein levels of IL-6 and IL-8 decreased from 993.0 +- 738.9 pg/mL to 650.1 +- 421.9 pg/mL (P = 0.014) and from 703.1 +- 278.0 pg/mL to 492.0 +- 214.9 pg/mL (P = 0.001), respectively, with 5 mug/mL theophylline treatment.	Theophylline	225-237	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
22363103-7	2012	In addition, theophylline at the dose of 5 mug/mL reduced the increased production of IL-6 and IL-8 induced by 1 mug/mL LPS in primary human lung fibroblasts.	Theophylline	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
22719178-6	2012	Much data showed that macrolides reduced viral titers of RV ICAM-1, which is the receptor for RV, and RV infection-induced cytokines including IL-1beta, IL-6, IL-8, and TNF-alpha.	Macrolides	22-32	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
22988345-7	2012	TNF-alpha treatment of IECs resulted in an association between EGFR and HER2 and inhibition of HER2 using a specific inhibitor AG879 in combination with AG1478-suppressed TNF-alpha-dependent ERK phosphorylation and IL-8 release.	RTKI cpd	153-159	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
22761540-3	2012	Clarithromycin (CAM), which is an antimicrobial agent and is also known as an immunomodulator, significantly suppressed RSV-induced production of interleukin-6, interleukin-8, and regulated on activation, normal T-cell expressed and secreted (RANTES).	Clarithromycin	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	161-174
21830064-8	2012	These results suggest that H2O2 upregulates the expression of ZNF580 via the NF-kappaB signaling pathway, and overexpression of ZNF580 plays a critical role in augmenting the release of pro-inflammatory cytokine IL-8.	Hydrogen Peroxide	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	212-216
22761540-3	2012	Clarithromycin (CAM), which is an antimicrobial agent and is also known as an immunomodulator, significantly suppressed RSV-induced production of interleukin-6, interleukin-8, and regulated on activation, normal T-cell expressed and secreted (RANTES).	Clarithromycin	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	161-174
21956503-4	2012	We show that hydrogen peroxide-induced oxidative stress can cause a ~twofold decrease in the number of lymphocytes secreting the TH1 cytokines IFN-gamma and IL-2, as well as chemokines IL-8 and TNF-alpha.	Hydrogen Peroxide	13-30	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
23093820-9	2012	Comparison of the dose-dependent inhibition of chemokine (IL-8, IP-10, MCP-1) and growth factor (GM-CSF) release from PHK activated by TNFalpha + IFNgamma showed that leontopodic acid was mainly responsible for the inhibitory effects of ECC55.	leontopodic acid	167-183	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
22355254-9	2012	Duration of topical Timolol and Alphagan therapy correlated negatively with CXCL8 (r=-0.588, p=0.035), respectively.	Timolol	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	76-81
21999396-4	2012	Among the constituents, matrine, baicalin, ursolic acid, sodium danshensu, magnolol, honokiol, hesperidin and andrographolide significantly reduced IL-8 and TNF-alpha by human HaCaT keratinocyte cells pretreated with heat-killed P. acnes.	matrine	24-31	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
22605930-10	2012	Interestingly, Travatan and Systane Ultra activated NF-kappaB and elevated the secretion of inflammation markers IL-6 by 3 to eightfold and IL-8 by 1.5 to 3.5 fold, respectively, as analyzed with ELISA.	Travoprost	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
22605930-10	2012	Interestingly, Travatan and Systane Ultra activated NF-kappaB and elevated the secretion of inflammation markers IL-6 by 3 to eightfold and IL-8 by 1.5 to 3.5 fold, respectively, as analyzed with ELISA.	SCHEMBL21048105	28-35	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
21999396-4	2012	Among the constituents, matrine, baicalin, ursolic acid, sodium danshensu, magnolol, honokiol, hesperidin and andrographolide significantly reduced IL-8 and TNF-alpha by human HaCaT keratinocyte cells pretreated with heat-killed P. acnes.	andrographolide	110-125	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
21999396-4	2012	Among the constituents, matrine, baicalin, ursolic acid, sodium danshensu, magnolol, honokiol, hesperidin and andrographolide significantly reduced IL-8 and TNF-alpha by human HaCaT keratinocyte cells pretreated with heat-killed P. acnes.	baicalin	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
21999396-4	2012	Among the constituents, matrine, baicalin, ursolic acid, sodium danshensu, magnolol, honokiol, hesperidin and andrographolide significantly reduced IL-8 and TNF-alpha by human HaCaT keratinocyte cells pretreated with heat-killed P. acnes.	ursolic acid	43-55	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
21999396-4	2012	Among the constituents, matrine, baicalin, ursolic acid, sodium danshensu, magnolol, honokiol, hesperidin and andrographolide significantly reduced IL-8 and TNF-alpha by human HaCaT keratinocyte cells pretreated with heat-killed P. acnes.	Sodium Danshensu	57-73	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
21999396-4	2012	Among the constituents, matrine, baicalin, ursolic acid, sodium danshensu, magnolol, honokiol, hesperidin and andrographolide significantly reduced IL-8 and TNF-alpha by human HaCaT keratinocyte cells pretreated with heat-killed P. acnes.	magnolol	75-83	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
21999396-4	2012	Among the constituents, matrine, baicalin, ursolic acid, sodium danshensu, magnolol, honokiol, hesperidin and andrographolide significantly reduced IL-8 and TNF-alpha by human HaCaT keratinocyte cells pretreated with heat-killed P. acnes.	honokiol	85-93	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
21999396-4	2012	Among the constituents, matrine, baicalin, ursolic acid, sodium danshensu, magnolol, honokiol, hesperidin and andrographolide significantly reduced IL-8 and TNF-alpha by human HaCaT keratinocyte cells pretreated with heat-killed P. acnes.	Hesperidin	95-105	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
22973975-7	2012	Preincubation of Detroit cells with 200 muM curcumin for 5 to 60 min resulted in complete suppression of the release of tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, monocyte chemoattractant protein 1, granulocyte macrophage-colony stimulating factor, and vascular endothelial growth factor.	Curcumin	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
23051896-0	2012	Dopamine agonists upregulate IL-6 and IL-8 production in human keratinocytes.	Dopamine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
23051896-8	2012	RESULTS: Dopamine stimulated the production of IL-6 and IL-8 in a concentration-dependent manner.	Dopamine	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
23051896-11	2012	The latter drug was able to block the effect of dopamine on the secretion of IL-8.	Dopamine	48-56	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
21958850-0	2012	Synthesis of [11C]interleukin 8 using a cell-free translation system and L-[11C]methionine.	Carbon-11	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
21958850-0	2012	Synthesis of [11C]interleukin 8 using a cell-free translation system and L-[11C]methionine.	l-[11c]methionine	73-90	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
21925926-13	2012	Taken together, LPA may be a potent inducer of osteolytic factor IL-6 and IL-8 in OSCC.	lysophosphatidic acid	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
21958850-5	2012	In this study, [(11)C]interleukin 8 (IL-8; MW 9.2 kDa) was successfully synthesized by the cell-free system in combination with l-[(11)C]methionine.	l-[(11)c]methionine	128-147	C-X-C motif chemokine ligand 8	Homo sapiens	15-35
21958850-5	2012	In this study, [(11)C]interleukin 8 (IL-8; MW 9.2 kDa) was successfully synthesized by the cell-free system in combination with l-[(11)C]methionine.	l-[(11)c]methionine	128-147	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
21925926-14	2012	LPA-induced IL-6 and IL-8 exerted propound effects on RANKL expression in osteoblast and thereby promoted osteoclast formation from osteoclast precursors.	lysophosphatidic acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
21925926-0	2012	Secretion of IL-6 and IL-8 from lysophosphatidic acid-stimulated oral squamous cell carcinoma promotes osteoclastogenesis and bone resorption.	lysophosphatidic acid	32-53	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
21925926-6	2012	LPA induced the secretion of IL-6 and IL-8 in oral squamous cell carcinoma (OSCC).	lysophosphatidic acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
22952917-6	2012	PBMCs from patients with ASA produce typically less IL-13, IL-7, IL-17 and MIG, and more MIP-1beta and IL-8, as compared to PBMCs from patients without ASA.	Aspirin	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
21925926-7	2012	LPA-stimulated secretion of IL-6 and IL-8 is partly dependent on the LPA and EGF receptor (EGFR) pathways.	lysophosphatidic acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
21925926-8	2012	ERK1/2 and Akt-mediated NF-kappaB and AP-1 were responsible for the LPA-induced IL-6 and IL-8 secretion.	lysophosphatidic acid	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
21925926-10	2012	Neutralization against both human IL-6 and IL-8 suppressed osteoclast formation induced by CM derived from the LPA-stimulated OSCC.	lysophosphatidic acid	111-114	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
21925926-11	2012	Direct treatment with recombinant IL-6 (rIL-6) and/or soluble IL-6 receptor (sIL-6R), or IL-8 (rIL-8) reproduced the effect of the CM derived from the LPA-stimulated OSCC on osteoclast formation.	lysophosphatidic acid	151-154	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
23272151-6	2012	Likewise, stimulation of autophagy by nutrient starvation or rapamycin treatment reduced intracellular AIEC survival and IL-8 production.	Sirolimus	61-70	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
23110185-8	2012	Treatment of neutrophils from healthy subjects with TNFalpha, IL-1beta, or IL-8 enhanced free radicals generation and NETs formation, which was mediated through the activation of NADPH oxidase and MPO.	Free Radicals	89-102	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
23028541-13	2012	Over 97% of PSS samples were distinguished from controls by elevated CXCL10 (&gt;500 ng/mL), CXCL8 (&gt;30 ng/mL) and CCL2 (&gt;60 ng/mL) levels.	pss	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	93-98
22685620-5	2012	There was a significant decrease in IL-8 release from PBLs stimulated with H(2)O(2) incubated with (U), (C), (C&amp;D), and (STD) herbs and from Caco-2 cells stimulated with TNFalpha incubated with (C&amp;D) and (STD) herbs.	Adenosine Monophosphate	112-115	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
22936990-1	2012	CXCR1, a classic GPCR that binds IL-8, plays a key role in neutrophil activation and migration by activating phospholipase C (PLC)beta through Galpha(15) and Galpha(i) which generates diacylglycerol and inositol phosphates (IPs).	Diglycerides	184-198	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
22916253-11	2012	Moreover, we found that both LPS and CpG oligodeoxynucleotides (ODN) induced robust pro-inflammatory responses in thrombocytes, as characterized by more than 100 fold increase in interleukin (IL)-1beta, IL-6 and IL-8 transcripts, while only LPS enhanced nitric oxide production and phagocytic capabilities.	CPG-oligonucleotide	37-62	C-X-C motif chemokine ligand 8	Homo sapiens	212-216
22936990-1	2012	CXCR1, a classic GPCR that binds IL-8, plays a key role in neutrophil activation and migration by activating phospholipase C (PLC)beta through Galpha(15) and Galpha(i) which generates diacylglycerol and inositol phosphates (IPs).	Inositol Phosphates	203-222	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
22936990-1	2012	CXCR1, a classic GPCR that binds IL-8, plays a key role in neutrophil activation and migration by activating phospholipase C (PLC)beta through Galpha(15) and Galpha(i) which generates diacylglycerol and inositol phosphates (IPs).	Inositol Phosphates	224-227	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
22815786-6	2012	Atorvastatin increased the intracellular contents of GRO-alpha, IL-8, and MCP-1 and induced colocalization with E-selectin in multivesicular bodies.	Atorvastatin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
22911818-4	2012	METHODOLOGY/PRINCIPAL FINDINGS: Corticosteroid sensitivity was determined by measuring dexamethasone inhibition of CD3/28 and TNF-alpha induced IL-8 production in PBMCs by using ELISA.	Dexamethasone	87-100	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
22479453-0	2012	Methamphetamine increases LPS-mediated expression of IL-8, TNF-alpha and IL-1beta in human macrophages through common signaling pathways.	Methamphetamine	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
22590561-4	2012	RESULTS: Administration of 5-FU but not pemetrexed potentiated CXCL8 secretion and increased CXCR1 and CXCR2 gene expression in metastatic PC3 cells.	Fluorouracil	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	63-68
22590561-5	2012	Consistent with this, the inhibition of CXCL8 signaling using a CXCR2 antagonist, AZ10397767, increased the cytotoxicity of 5-FU by 4-fold (P&lt;0.001), and increased 5-FU-induced apoptosis in PC3 cells (P&lt;0.01).	AZ10397767	82-92	C-X-C motif chemokine ligand 8	Homo sapiens	40-45
22590561-5	2012	Consistent with this, the inhibition of CXCL8 signaling using a CXCR2 antagonist, AZ10397767, increased the cytotoxicity of 5-FU by 4-fold (P&lt;0.001), and increased 5-FU-induced apoptosis in PC3 cells (P&lt;0.01).	Fluorouracil	124-128	C-X-C motif chemokine ligand 8	Homo sapiens	40-45
22590561-5	2012	Consistent with this, the inhibition of CXCL8 signaling using a CXCR2 antagonist, AZ10397767, increased the cytotoxicity of 5-FU by 4-fold (P&lt;0.001), and increased 5-FU-induced apoptosis in PC3 cells (P&lt;0.01).	Fluorouracil	167-171	C-X-C motif chemokine ligand 8	Homo sapiens	40-45
22590561-8	2012	Moreover, siRNA-mediated knockdown of the CXCL8-target gene Bcl-2 increased the sensitivity of PC3 cells to 5-FU.	Fluorouracil	108-112	C-X-C motif chemokine ligand 8	Homo sapiens	42-47
22715377-6	2012	A comparative transcriptomic analysis performed in HEK-293 cells expressing either wild-type HA-p65 or a non-phosphorylatable mutant HA-p65(S547A) identified several differentially transcribed genes after an etoposide treatment (e.g. IL8, A20, SELE).	Etoposide	208-217	C-X-C motif chemokine ligand 8	Homo sapiens	234-237
22715377-9	2012	Cells expressing p65(S547A) have a higher level of histone H3 acetylated on Lys(9) at the IL8 promoter, which is in agreement with the higher gene induction observed.	Lysine	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
22586462-2	2012	They consist of a conserved three-dimensional (3D) structure, so-called IL8-like chemokine fold, which is supported by disulfide bridges characteristic of this protein family.	Disulfides	119-128	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
22396773-6	2012	Consistently, TPT-treated cells exhibit elevated expression of multiple cytokines such as IFN-beta, TNF-alpha, IL-6 and IL-8.	Topotecan	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
22470478-9	2012	However, Que is more effective than cromolyn in inhibiting IL-8 and TNF release from LAD2 mast cells stimulated by SP.	Quercetin	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
22470478-9	2012	However, Que is more effective than cromolyn in inhibiting IL-8 and TNF release from LAD2 mast cells stimulated by SP.	Cromolyn Sodium	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
22363678-3	2012	We report here that next to the beta(2)-agonist fenoterol, direct and specific activation of either exchange protein directly activated by cAMP (Epac) or protein kinase A (PKA) reduced cigarette smoke extract (CSE)-induced IL-8 mRNA expression and protein release by human ASM cells.	Cyclic AMP	139-143	C-X-C motif chemokine ligand 8	Homo sapiens	223-227
22469636-10	2012	Interestingly, proinflammatory IL-8 was elevated in those subjects with evidence of AT and E compared to those with AT and NAD.	nadide	123-126	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
22295067-10	2012	In terms of trans-repression, CpdA and ZK216348 effectively inhibited NF-kappaB activity and IL-8 secretion, but showed less trans-activation potency.	CPDA	30-34	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
22295067-10	2012	In terms of trans-repression, CpdA and ZK216348 effectively inhibited NF-kappaB activity and IL-8 secretion, but showed less trans-activation potency.	ZK 216348	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
22036725-11	2012	In addition, SM enhanced phosphorylation of NF-kB p65 and release of TNF-alpha, interleukin (IL)-6 and IL-8.	Samarium	13-15	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
20665032-0	2012	Nicotine inhibits tumor necrosis factor-alpha induced IL-6 and IL-8 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
20665032-4	2012	Nicotine at concentrations of 0.1-10 muM dose reduced the protein and mRNA expression of IL-6 and IL-8 induced by tumor necrosis factor-alpha (TNFalpha).	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
23091851-8	2012	The CHD and MS patients who carried the Pro allele showed a significant metformin-induced reduction in weight, waist circumference, body mass index, and concentrations of TC, C-peptide, and cytokines, such IL-1beta, IL-6, IL-8, and TNF-alpha.	Metformin	72-81	C-X-C motif chemokine ligand 8	Homo sapiens	222-226
22015448-0	2012	Interleukin-8 (IL-8) over-production and autocrine cell activation are key factors in monomethylarsonous acid [MMA(III)]-induced malignant transformation of urothelial cells.	monomethylarsonous acid	86-109	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
22289755-6	2012	Compared with the HSP serum group, the levels of IL-8, TNF-alpha, and NO in the HSP serum plus methylprednisolone group decreased significantly (P&lt;0.05).	Methylprednisolone	95-113	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
22015448-0	2012	Interleukin-8 (IL-8) over-production and autocrine cell activation are key factors in monomethylarsonous acid [MMA(III)]-induced malignant transformation of urothelial cells.	monomethylarsonous acid	86-109	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
21798286-4	2011	However, HuMCs from the remaining donors and the LAD2 human MC line responded to PGE(2) and sulprostone with marked enhancement of antigen-mediated degranulation and IL-8 production in a similar manner to that observed in mouse BMMCs.	Methylcholanthrene	11-13	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
21798286-4	2011	However, HuMCs from the remaining donors and the LAD2 human MC line responded to PGE(2) and sulprostone with marked enhancement of antigen-mediated degranulation and IL-8 production in a similar manner to that observed in mouse BMMCs.	Prostaglandins E	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
21975045-0	2011	Influence of sodium fluoride (NaF) on the crystallization and spectral properties of L-tyrosine.	Sodium Fluoride	13-28	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
21975045-0	2011	Influence of sodium fluoride (NaF) on the crystallization and spectral properties of L-tyrosine.	Tyrosine	85-95	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
21975045-3	2011	L-Tyrosine has been crystallized in silica gel by double diffusion technique with and without the addition of NaF.	Tyrosine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	110-113
21975045-9	2011	Optical band gap energy of NaF grown l-tyrosine crystallite is estimated as 4.28eV.	Tyrosine	37-47	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
21877251-8	2011	Using oligonucleotide microarray, we demonstrated a dramatic increase in proinflammatory cytokine and chemokine transcripts (CXCL10, CXCL11, TNFSF10, CCL5, CCL4, CCL2, IFNB1, CCL20, IL-8, and CCL11).	Oligonucleotides	6-21	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
22029665-5	2011	The effect of fluorine source on the optical properties of UCNPs was investigated by using NH(4)F, NH(4)HF(2), NaF, and 1-butyl-3-methylimidazolium tetrafluoroborate (BmimBF(4)) as different fluorine sources; NH(4)F proved to be the best one, making the luminescent intensity increase at least 2 orders of magnitude.	Fluorine	14-22	C-X-C motif chemokine ligand 8	Homo sapiens	111-114
21930886-5	2011	Rifampin significantly increased the secretion of interleukin 8 (IL-8) in both untreated cells (P &lt; 0.001) and cytokine-treated cells (P &lt; 0.006).	Rifampin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	50-63
21930886-5	2011	Rifampin significantly increased the secretion of interleukin 8 (IL-8) in both untreated cells (P &lt; 0.001) and cytokine-treated cells (P &lt; 0.006).	Rifampin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
25386288-6	2011	In addition, ellagic acid promoted G1 cell cycle arrest, increased levels of apoptosis and decreased synthesis of IL-1beta and IL-8 in melanoma cells.	Ellagic Acid	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
21778813-4	2011	Because CXCL8 played an important role in neutrophil infiltration and activation, we performed the LMT and measured CXCL8 levels in patients with hypersensitivity to beta-lactam antibiotics (beta-lactams) and antipyretic analgesics (APAs) and investigated the pathogenic mechanism of hypersensitivity to these drugs.	beta-Lactams	166-177	C-X-C motif chemokine ligand 8	Homo sapiens	8-13
21778813-7	2011	The CXCL8 concentrations were significantly higher in patients after beta-lactams administration (175.9 +- 71.2 ng/mL) than those without beta-lactams administration (48.3 +- 34.9 ng/mL).	beta-Lactams	69-81	C-X-C motif chemokine ligand 8	Homo sapiens	4-9
21778813-7	2011	The CXCL8 concentrations were significantly higher in patients after beta-lactams administration (175.9 +- 71.2 ng/mL) than those without beta-lactams administration (48.3 +- 34.9 ng/mL).	beta-Lactams	138-150	C-X-C motif chemokine ligand 8	Homo sapiens	4-9
21778813-9	2011	CONCLUSIONS: Increased CXCL8 levels produced by beta-lactams administration were accompanied by LMIA.	beta-Lactams	48-60	C-X-C motif chemokine ligand 8	Homo sapiens	23-28
21778813-10	2011	CXCL8 may be involved in LMIA and play a role in beta-lactam allergies.	beta-Lactams	49-60	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
22829094-3	2011	AZD1480 at low doses (0.1-1 mu) potently inhibited STATs phosphorylation, but did not predictably result in antiproliferative effects, as it activated a negative-feedback loop causing phosphorylation of JAK2 and extracellular signal-regulated kinases 1 and 2 (ERK1/2), and increased IP-10, RANTES and interleukin (IL)-8 concentrations in the supernatants.	AZD 1480	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	301-319
21996014-6	2011	A newly developed CS induced rat COPD model was employed to study time courses of IL-17 and IL-8 release and nucleated cell accumulation.	Cesium	18-20	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
22092504-9	2011	RESULTS: Although Dex dose dependently inhibited IL-8 release induced by 5 ng/mL IL-13, Dex 0.001-1 mug/mL had no effect on IL-13 induced MUC5AC protein secretion or mRNA expression.	Dexamethasone	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
21479633-7	2011	DHA significantly inhibited NF-kappaB DNA-binding activity, so as to tremendously decrease the expression of NF-kappaB-targeted proangiogenic gene products: VEGF, IL-8, COX-2, and MMP-9 in vitro.	artenimol	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
21996445-9	2011	DISCUSSION: Nickel ions from the Ni-Cr alloys permeated the epithelial cells and activated a proinflammatory response, namely IL-1a, IL-8 and PGE2 expression.	Nickel	12-18	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
21963154-7	2011	Low levels of dityrosine cross-links were detected in copper/H2O2-treated IL-8 (CXCL8), which has one tyrosine residue, and none were detected in ENA-78 (CXCL5), which has none.	dityrosine	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
21996445-9	2011	DISCUSSION: Nickel ions from the Ni-Cr alloys permeated the epithelial cells and activated a proinflammatory response, namely IL-1a, IL-8 and PGE2 expression.	Chromium	36-38	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
21963154-7	2011	Low levels of dityrosine cross-links were detected in copper/H2O2-treated IL-8 (CXCL8), which has one tyrosine residue, and none were detected in ENA-78 (CXCL5), which has none.	Copper	54-60	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
22031535-4	2011	LMW-HA-activated AFAP-110 then binds to filamentous actin (F-actin) resulting in MyD88/nuclear factor-kappaB (NF-kappaB) nuclear translocation, NF-kappaB-specific transcription, and target gene [interleukine 1beta and interleukine-8 (IL-1beta and IL-8)] expression.	lmw-ha	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	247-251
21963154-7	2011	Low levels of dityrosine cross-links were detected in copper/H2O2-treated IL-8 (CXCL8), which has one tyrosine residue, and none were detected in ENA-78 (CXCL5), which has none.	Hydrogen Peroxide	61-65	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
21995333-0	2011	Mast cell-derived TNF-alpha and histamine modify IL-6 and IL-8 expression and release from cutaneous tumor cells.	Histamine	32-41	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
21963154-7	2011	Low levels of dityrosine cross-links were detected in copper/H2O2-treated IL-8 (CXCL8), which has one tyrosine residue, and none were detected in ENA-78 (CXCL5), which has none.	Tyrosine	16-24	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
21964048-5	2011	The treatment of EPCs with TLR3 agonist Poly I:C up-regulated the expression of cytokines IL-1beta, IL-6, IL-8, TNF-alpha, IFN-alpha, and IFN-beta, indicating that EPCs expressed functional TLR3.	Poly I	40-46	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
21930764-7	2011	Activation of the IL-8 promoter in transfected HEK293 cells was inhibited by manumycin A, BAY43-9006, U0126, and transfection with a dominant-negative Ras mutant.	manumycin	77-88	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
21930764-7	2011	Activation of the IL-8 promoter in transfected HEK293 cells was inhibited by manumycin A, BAY43-9006, U0126, and transfection with a dominant-negative Ras mutant.	Sorafenib	90-100	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
21964048-5	2011	The treatment of EPCs with TLR3 agonist Poly I:C up-regulated the expression of cytokines IL-1beta, IL-6, IL-8, TNF-alpha, IFN-alpha, and IFN-beta, indicating that EPCs expressed functional TLR3.	Carbon	19-20	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
21930764-7	2011	Activation of the IL-8 promoter in transfected HEK293 cells was inhibited by manumycin A, BAY43-9006, U0126, and transfection with a dominant-negative Ras mutant.	U 0126	102-107	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
21414766-5	2011	Nicotinamide treatment resulted in a significant reduction of basal and/or LPS-stimulated release and gene expression of the pro-inflammatory cytokines TNF-alpha, IL-6 and the chemokine IL-8, and the release of the prostaglandins PGE(2) and PGF(2)alpha and cyclooxygenase (COX)-2 mRNA expression.	Niacinamide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
21956421-11	2011	When treated with TSH, thyroid fibroblasts generate IL-6 and IL-8.	Thyrotropin	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
22125787-10	2011	The IC25 of IL-8 inhibition by dexamethasone was higher in nasal polyp than in nasal mucosa fibroblasts.	Dexamethasone	31-44	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
21917909-5	2011	Corticosteroid (dexamethasone) sensitivity was determined on tumor necrosis factor-alpha (TNF-alpha)-induced interleukin (IL)-8 production.	Dexamethasone	16-29	C-X-C motif chemokine ligand 8	Homo sapiens	109-127
21903370-8	2011	MKP-1 mRNA was increased and IL-8 mRNA was significantly inhibited by BUD800, SYM100 and SYM200 versus placebo.	bud800	70-76	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
21824526-3	2011	Stimulation with TvSP induced up-regulation of IL-8 protein secretion in HMC-1 cells.	tvsp	17-21	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
21824526-6	2011	Moreover, TvSP-induced IL-8 production and phosphorylation of NF-kappaB or CREB were inhibited when HMC-1 cells were stimulated with modified TvSP collected from 5-lipooxygenase inhibitor-treated trichomonads.	tvsp	10-14	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
21824526-6	2011	Moreover, TvSP-induced IL-8 production and phosphorylation of NF-kappaB or CREB were inhibited when HMC-1 cells were stimulated with modified TvSP collected from 5-lipooxygenase inhibitor-treated trichomonads.	tvsp	142-146	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
21824526-9	2011	Finally, TvSP-induced IL-8 production was inhibited by pretreatment with IkappaB or CREB inhibitors.	tvsp	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
21964474-5	2011	Normalized IL-8 concentration for C60(OH)20 was not significantly different from control, while C60(OH)24 and C60(OH)32 showed a significant decrease at 24 and 48 h. These results suggest that different hydroxylation of fullerenes caused no cytotoxicity or inflammation up to 8.55 mug/ml.	Fullerenes	220-230	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
22107692-8	2011	Citrate could significantly decrease systemic pre-filter serum MPO levels from baseline at 6 h (median 43.5 vs. 17.3 ng/mL, P&lt;0.01) as well as IL-8 levels (P&lt;0.05) whereas heparin provided only significant TNF-alpha reduction (P&lt;0.05).	Citric Acid	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
22107694-0	2011	Down-modulation of toll-like receptor 2 expression on granulocytes and suppression of interleukin-8 production due to in vitro treatment with cellulose acetate beads.	acetylcellulose	142-159	C-X-C motif chemokine ligand 8	Homo sapiens	86-99
22525504-7	2011	p38 MAPK inhibitor (SB203580) could significantly inhibit IL-8 production in a dose-dependent manners (F = 65.47, P &lt; 0.01), and partially inhibited NF-kB p65 nuclear translocation in a dose-dependent manner (F=141.20, P &lt; 0.05).	SB 203580	20-28	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
22152804-4	2011	Furthermore, whether TLR4 inhibitor, TAK-242, could interrupt the expression of TRIF as well as some inflammatory cytokines such as IL-6, IL-8 and TNF-alpha in THP-1 cells stimulated with beta2 GPI/anti-beta2 GPI complex was also investigated.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	37-44	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
22019593-0	2011	Interactions of interleukin-8 with the human chemokine receptor CXCR1 in phospholipid bilayers by NMR spectroscopy.	Phospholipids	73-85	C-X-C motif chemokine ligand 8	Homo sapiens	16-29
22019593-8	2011	The interaction is tight enough to immobilize IL-8 along with the receptor in phospholipid bilayers and is specific enough to result in well-aligned samples in oriented sample solid-state NMR spectra.	Phospholipids	78-90	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
21493783-0	2011	Steroid-insensitive ERK1/2 activity drives CXCL8 synthesis and neutrophilia by airway smooth muscle.	Steroids	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	43-48
21925595-7	2011	Importantly, both severe (0.5% O(2)) and mild (5% O(2)) hypoxia diminished IL-8 expression despite the stabilization of both HIF-1 and HIF-2.	o(2))	31-36	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
21925595-7	2011	Importantly, both severe (0.5% O(2)) and mild (5% O(2)) hypoxia diminished IL-8 expression despite the stabilization of both HIF-1 and HIF-2.	o(2)	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
21820074-13	2011	Humic acid also induces the release of IL-8 from human monocytes and enhances the CSE-induced IL-8 release.	Humic Substances	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
21820074-13	2011	Humic acid also induces the release of IL-8 from human monocytes and enhances the CSE-induced IL-8 release.	Humic Substances	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
21820074-15	2011	Moreover, humic acid promotes IL-8 release from human monocytes.	Humic Substances	10-20	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
21840384-9	2011	Air followed by Asp exposure tended to induce IL-8 expression whereas IL-8 production tended to increase after FA and Asp exposure compared to FA and air exposure.	Aspartic Acid	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
21840384-9	2011	Air followed by Asp exposure tended to induce IL-8 expression whereas IL-8 production tended to increase after FA and Asp exposure compared to FA and air exposure.	Aspartic Acid	118-121	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
21493783-5	2011	In ex vivo ASMCs, TNF-alpha but not IL-17A induced expression of the neutrophil chemoattractant CXCL8.	asmcs	11-16	C-X-C motif chemokine ligand 8	Homo sapiens	96-101
21925169-6	2011	PGE2 increased the second EGFR-P and IL-8 production via binding to its Gi-protein-coupled E-prostanoid (EP)3 receptor.	Dinoprostone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
22010965-8	2011	Furthermore, the basal cytokine profile (high IL-8, MIG, IP-10 and IL-4 levels and low IL-5, MIP1a, MIP1b, IL12/p70) was predictive of clinical response to lenalidomide.	Lenalidomide	156-168	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
21946433-4	2011	Monosodium urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6, the chemokine CXCL8 and the matrix metalloproteinase (MMP)-1 from both normal and RA-FLS (all P&lt;0.05).	Uric Acid	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	123-128
21946433-5	2011	Moreover, the additive or synergistic effect on the release of IL-6, CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-alpha or IL-1beta.	Uric Acid	164-180	C-X-C motif chemokine ligand 8	Homo sapiens	69-74
21742513-0	2011	Autocrine production of interleukin-8 confers cisplatin and paclitaxel resistance in ovarian cancer cells.	Cisplatin	46-55	C-X-C motif chemokine ligand 8	Homo sapiens	24-37
21742513-0	2011	Autocrine production of interleukin-8 confers cisplatin and paclitaxel resistance in ovarian cancer cells.	Paclitaxel	60-70	C-X-C motif chemokine ligand 8	Homo sapiens	24-37
21925169-8	2011	Thus, we conclude that a positive feedback pathway involving COX-2/PGE2/EP3 receptor-dependent EGFR reactivation exaggerates IL-8 production in NCI-H292 cancer cells but not in NHBE (normal) cells.	Dinoprostone	67-71	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
21785859-6	2011	In addition, cysteine and histidine significantly inhibited the expression of ICAM-1 and production of IL-8 in THP-1 cells and PBMCs.	Cysteine	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
21785859-6	2011	In addition, cysteine and histidine significantly inhibited the expression of ICAM-1 and production of IL-8 in THP-1 cells and PBMCs.	Histidine	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
22000456-6	2011	Resveratrol enhanced LPS- and heat stress-induced expression of HO-1 and hBD-2 but reduced IL-8 messenger RNA levels.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
22086795-7	2011	RESULTS: Among 12 cytokines, IL-6, IL-8, IL-10, and TNF-alpha were significantly elevated in patients with resistance against lamivudine compared with patients maintaining response.	Lamivudine	126-136	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
21865591-8	2011	Furthermore, synthetic ghrelin inhibited the production of IL-8 from TNF-alpha or LPS-stimulated oral epithelial cells.	Ghrelin	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
21716324-5	2011	Bafilomycin A1, which inhibits endosomal acidification to block the TLR3 pathway, blocked the dsRNA-induced expression of TSLP, IL-8, IFN-beta, and other molecules including the dsRNA sensors, whereas it did not inhibit diacyllipopeptide-induced expression of TSLP and IL-8.	bafilomycin A1	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
21716324-5	2011	Bafilomycin A1, which inhibits endosomal acidification to block the TLR3 pathway, blocked the dsRNA-induced expression of TSLP, IL-8, IFN-beta, and other molecules including the dsRNA sensors, whereas it did not inhibit diacyllipopeptide-induced expression of TSLP and IL-8.	bafilomycin A1	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	269-273
21796149-3	2011	beta-Glucan stimulation significantly increased IL-8, IL-6, and IL-1alpha production by NHEKs.	beta-Glucans	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
21796149-4	2011	Well-differentiated NHEKs produced elevated IL-8 levels, whereas ATP, a danger signal, significantly increased IL-8 and IL-6 production, and the pathogen-associated compound, poly(I:C), augmented IL-1alpha production by beta-glucan-stimulated NHEKs.	Adenosine Triphosphate	65-68	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
21796149-10	2011	Treatment with the ERK inhibitor PD98059 and with the p38 kinase inhibitor SB203580 effectively suppressed beta-glucan-induced IL-8 production by NHEKs.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	33-40	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
21796149-10	2011	Treatment with the ERK inhibitor PD98059 and with the p38 kinase inhibitor SB203580 effectively suppressed beta-glucan-induced IL-8 production by NHEKs.	SB 203580	75-83	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
21796149-10	2011	Treatment with the ERK inhibitor PD98059 and with the p38 kinase inhibitor SB203580 effectively suppressed beta-glucan-induced IL-8 production by NHEKs.	beta-Glucans	107-118	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
21417583-4	2011	Therefore, we investigated the effects of AZM on IL-8 production in an oral epithelial cell line.	Azithromycin	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
21417583-8	2011	RESULTS: IL-8 mRNA expression, IL-8 production, and NF-kappaB activation in LPS-stimulated KB cells were inhibited by the addition of AZM.	Azithromycin	134-137	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
21417583-8	2011	RESULTS: IL-8 mRNA expression, IL-8 production, and NF-kappaB activation in LPS-stimulated KB cells were inhibited by the addition of AZM.	Azithromycin	134-137	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
21417583-10	2011	CONCLUSIONS: This study suggests that AZM inhibits LPS-induced IL-8 production in an oral epithelial cell line, in part caused by the suppression of Rac1 and NF-kappaB activation.	Azithromycin	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
21842098-4	2011	The results obtained demonstrated that zinc, nickel and cadmium significantly activate NF-kappaB, and the release of the chemokine IL-8.	Nickel	45-51	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
21842098-4	2011	The results obtained demonstrated that zinc, nickel and cadmium significantly activate NF-kappaB, and the release of the chemokine IL-8.	Cadmium	56-63	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
22292182-46	2011	CONCLUSION: Hyperoxia induced intracellular ROS production can up-regulate TLR2/4 expression in A549 cells, leading to the release pro-inflammatory cytokines IL-6 and IL-8 from these cells.	Reactive Oxygen Species	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
21992677-0	2011	Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in cystic fibrosis cells.	parthenolide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
21936573-2	2011	Crude MRPs derived from Glu-Lys showed the greatest capacity (P &lt; 0.05) to inhibit nitric oxide (NO) and interleukin 8 (IL-8) production in interferon gamma and phorbol ester-induced Caco-2 cells.	Glucose	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	108-121
21936573-2	2011	Crude MRPs derived from Glu-Lys showed the greatest capacity (P &lt; 0.05) to inhibit nitric oxide (NO) and interleukin 8 (IL-8) production in interferon gamma and phorbol ester-induced Caco-2 cells.	Glucose	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
21936573-2	2011	Crude MRPs derived from Glu-Lys showed the greatest capacity (P &lt; 0.05) to inhibit nitric oxide (NO) and interleukin 8 (IL-8) production in interferon gamma and phorbol ester-induced Caco-2 cells.	Lysine	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	108-121
21936573-2	2011	Crude MRPs derived from Glu-Lys showed the greatest capacity (P &lt; 0.05) to inhibit nitric oxide (NO) and interleukin 8 (IL-8) production in interferon gamma and phorbol ester-induced Caco-2 cells.	Lysine	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
21936573-2	2011	Crude MRPs derived from Glu-Lys showed the greatest capacity (P &lt; 0.05) to inhibit nitric oxide (NO) and interleukin 8 (IL-8) production in interferon gamma and phorbol ester-induced Caco-2 cells.	Phorbol Esters	164-177	C-X-C motif chemokine ligand 8	Homo sapiens	108-121
21936573-2	2011	Crude MRPs derived from Glu-Lys showed the greatest capacity (P &lt; 0.05) to inhibit nitric oxide (NO) and interleukin 8 (IL-8) production in interferon gamma and phorbol ester-induced Caco-2 cells.	Phorbol Esters	164-177	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
21992677-11	2011	Since we previously showed that parthenolide inhibits excessive IL-8 production by CF cells, we evaluated its effects on MAPK and AP-1 activation and showed that parthenolide inhibited ERK and AP-1 activation.	parthenolide	32-44	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
21992677-11	2011	Since we previously showed that parthenolide inhibits excessive IL-8 production by CF cells, we evaluated its effects on MAPK and AP-1 activation and showed that parthenolide inhibited ERK and AP-1 activation.	parthenolide	162-174	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
21992677-12	2011	Using a luciferase promoter assay, our studies showed that parthenolide decreased activation of the IL-8 promoter in CF cells stimulated with TNFalpha/IL-1beta.	parthenolide	59-71	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
21992677-14	2011	Parthenolide inhibited both NFkappaB and MAPK/AP-1 pathways contributing to the inhibition of IL-8 production.	parthenolide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
21989944-0	2011	Low molecular weight hyaluronan, via AP-1 and NF-kappaB signalling, induces IL-8 in transformed bronchial epithelial cells.	Hyaluronic Acid	21-31	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
21925143-4	2011	Treatment of Ca9-22 cells and HOK with oxLDL induced an up-regulation of IL-8 and the PGE(2)-producing enzymes, cyclooxygenase-2 and microsomal PGE(2) synthase-1.	oxldl	39-44	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
21989944-2	2011	In addition, high tidal volume mechanical ventilation has been shown to increase IL-8 production in a mechanism mediated, at least in part, by low molecular weight hyaluronan (LWM-HA).	Hyaluronic Acid	164-174	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
21989944-2	2011	In addition, high tidal volume mechanical ventilation has been shown to increase IL-8 production in a mechanism mediated, at least in part, by low molecular weight hyaluronan (LWM-HA).	lwm-ha	176-182	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
21989944-7	2011	The inhibition of JNK, ERK1/2 and NF-kappaB blocked IL-8 secretion in response to LMW-HA.	lmw-ha	82-88	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
21989944-8	2011	CONCLUSION: The data suggest that LMW-HA produced by lung fibroblasts in response to cyclic stretch increases the secretion of IL-8 in transformed bronchial epithelial cells via AP-1 and NF-kappaB signalling pathways.	lmw-ha	34-40	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
21844189-7	2011	Aspirin was hydrolyzed by HEK cells transfected with PAFAH1B2 or PAFAH1B3, and the competitive type I PAF acetylhydrolase inhibitor NaF reduced erythrocyte hydrolysis of aspirin.	Aspirin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	132-135
21844189-7	2011	Aspirin was hydrolyzed by HEK cells transfected with PAFAH1B2 or PAFAH1B3, and the competitive type I PAF acetylhydrolase inhibitor NaF reduced erythrocyte hydrolysis of aspirin.	Aspirin	170-177	C-X-C motif chemokine ligand 8	Homo sapiens	132-135
21782151-7	2011	RESULTS: Before the administration of the drugs, aqueous levels of IL-8, IP-10, MCP-1, and VEGF were significantly higher in the DME group than in the control group.	dme	129-132	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
21919510-4	2011	The introduction of NaF into the solution combustion synthesis (SCS), which is a generally adopted synthetic route for mass productions of various oxide nanoparticles, results in better particle dispersity and a drastic increase in specific surface area compared to the conventional SCS.	Oxides	147-152	C-X-C motif chemokine ligand 8	Homo sapiens	20-23
21693690-6	2011	Stimulation of NOD1 with a synthetic ligand Tri-DAP induces proinflammatory chemokine MCP-1, RANTES, and cytokine TNF-alpha and MIP-2 (human IL-8 homolog) and IL-6 mRNA expression in 3T3-L1 adipocytes in a time- and dose-dependent manner.	L-Ala-gamma-D-Glu-meso-diaminopimelic acid	44-51	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
21297080-0	2011	Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cells.	Hydrogen Sulfide	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
21297080-6	2011	Exposure of ASM to H(2)S "donors" inhibited this proliferation and IL-8 release.	h(2)	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
21297080-9	2011	Inhibition of CBS, but not cystathionine-gamma-lyase, reversed the inhibitory effect of H(2)S on proliferation and IL-8 release, indicating that this is dependent on CBS.	Hydrogen Sulfide	88-93	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
21297080-11	2011	Finally, we found that exogenous H(2)S inhibited the phosphorylation of extracellular signal-regulated kinase-1/2 and p38, which could represent a mechanism by which H(2)S inhibited cellular proliferation and IL-8 release.	Hydrogen Sulfide	33-38	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
22103940-5	2011	In addition, skin irritation induced by an application of sodium dodecyl sulphate resulted in significantly higher lactate dehydrogenase leakage, and interleukin (IL)-6 and IL-8 levels, than in the control model.	Sodium Dodecyl Sulfate	58-81	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
21297080-11	2011	Finally, we found that exogenous H(2)S inhibited the phosphorylation of extracellular signal-regulated kinase-1/2 and p38, which could represent a mechanism by which H(2)S inhibited cellular proliferation and IL-8 release.	Hydrogen Sulfide	166-171	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
21707494-3	2011	Since the old anti-Hansen"s disease drug dapsone inhibits neutrophil migration along an IL-8 gradient towards increasing concentrations, and is used therapeutically for this attribute to good effect in dermatitis herpetiformis, bullous pemphigoid and rheumatoid arthritis, we suggest dapsone may deprive glioblastoma of neutrophil-mediated growth promoting effects.	Dapsone	41-48	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
21297080-12	2011	In summary, H(2)S production provides a novel mechanism for regulation of ASM proliferation and IL-8 release.	Hydrogen Sulfide	12-17	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
21734258-8	2011	RLN suppression of CSF2 and IL8 was sensitive to the GR-antagonist mifepristone (RU-486).	Mifepristone	67-79	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
21734258-8	2011	RLN suppression of CSF2 and IL8 was sensitive to the GR-antagonist mifepristone (RU-486).	Mifepristone	81-87	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
21771721-5	2011	12-O-tetradecanoylphorbol 13-acetate-induced differentiation of human U937 monocytes increased the expression and secretion of inflammatory cytokines such as tumor necrosis factor alpha, interleukin (IL)-6 and IL-8.	Tetradecanoylphorbol Acetate	0-36	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
21688034-7	2011	Erlotinib suppressed the production of osteolytic factors, such as parathyroid hormone-related protein (PTHrP), IL-8, IL-11 and vascular endothelial growth factor (VEGF) in NCI-H292 cells.	Erlotinib Hydrochloride	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
21724580-6	2011	In the vitamin D(3) supplementation group, TNF-alpha decreased 13%, IL-6 32%, IL-1beta 50%, and IL-8 15%; in the calcium supplementation group, IL-6 decreased 37%, IL-8 11%, and IL-1beta 27%.	Vitamin D	7-16	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
21436242-0	2011	Dapsone inhibits IL-8 secretion from human bronchial epithelial cells stimulated with lipopolysaccharide and resolves airway inflammation in the ferret.	Dapsone	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
21665565-3	2011	METHODS: We studied IL-8 expression and regulatory signaling pathways in cultured HAECs exposed to Mexicali PM suspended in media for 0-4 hr.	mexicali pm	99-110	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
21806984-10	2011	Finally, exposure of human colon biopsies from inflammatory bowel diseases patients to rifaximin reduced mRNA levels of IL-8, Rantes, MIP-3alpha and TNFalpha induced by LPS.	Rifaximin	87-96	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
21720792-8	2011	In addition, the serum levels of IFN-gamma and Cort were significantly higher and IL-8 levels were lower in CABP when compared to pyelonephritis or urosepsis.	2-CARBOXYARABINITOL-1,5-DIPHOSPHATE	108-112	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
21793939-6	2011	Association of Adapalene and BPO significantly decreased expression of Ki67, alpha(2) and alpha(6) integrins, TLR-2, beta-defensin 4 and IL-8 in inflammatory acne skin, whereas single treatments with Adapalene or BPO alone were less effective.	Adapalene	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
21793939-6	2011	Association of Adapalene and BPO significantly decreased expression of Ki67, alpha(2) and alpha(6) integrins, TLR-2, beta-defensin 4 and IL-8 in inflammatory acne skin, whereas single treatments with Adapalene or BPO alone were less effective.	Benzoyl Peroxide	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
20845069-0	2011	Synergistic effect of tumor necrosis factor-alpha and hydrogen peroxide on the induction of IL-8 production in human intestinal Caco-2 cells.	Hydrogen Peroxide	54-71	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
21762685-0	2011	Anti-inflammatory effects of garenoxacin on IL-8 production and ERK1/2 activation induced by lipopolysaccharides in A549 and THP-1 cells.	garenoxacin	29-40	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
21777689-0	2011	Safrole oxide induces human umbilical vein endothelial cell transdifferentiation to 5-hydroxytryptaminergic neuron-like cells through tropomyosin receptor kinase A/cyclooxygenase 2/nuclear factor-kappa B/interleukin 8 signaling.	safrole oxide	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	204-217
21777689-5	2011	Safrole oxide elevated the levels of cyclooxygenase 2 (COX-2), interleukin-8 (IL-8) and reactive oxygen species (ROS), which was accompanied by nuclear factor-kappa B (NF-kappaB) nuclear translocation during the transdifferentiation.	safrole oxide	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
21934447-8	2011	The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid.	Poly I	4-23	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
21777689-5	2011	Safrole oxide elevated the levels of cyclooxygenase 2 (COX-2), interleukin-8 (IL-8) and reactive oxygen species (ROS), which was accompanied by nuclear factor-kappa B (NF-kappaB) nuclear translocation during the transdifferentiation.	safrole oxide	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
21777689-9	2011	During this process, the increased levels of COX-2/IL-8 and the subsequent elevation of ROS production induced NF-kappaB nuclear translocation and IL-8 secretion.	Reactive Oxygen Species	88-91	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
21744278-5	2011	SP600125 attenuated t10,c12 CLA-mediated induction of inflammatory genes, including interleukin (IL)-6, IL-8, IL-1beta, ATF3, monocyte chemoattractant protein (MCP)-1, and cyclooxygenase-2.	pyrazolanthrone	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
21744278-6	2011	Consistent with these data, SP600125 prevented t10,c12 CLA-mediated secretion of IL-8, IL-6, and MCP-1.	pyrazolanthrone	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
21934447-6	2011	Poly (inosinic acid:cytidylic acid) by itself stimulated the release of IL-6 (305 pg/mL) and enhanced IL-8 production (2.8 ng/mL).	Poly I	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
21934447-6	2011	Poly (inosinic acid:cytidylic acid) by itself stimulated the release of IL-6 (305 pg/mL) and enhanced IL-8 production (2.8 ng/mL).	Cytidine Monophosphate	20-34	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
21934447-8	2011	The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid.	Cytidine Monophosphate	24-39	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
21934447-7	2011	The combination of poly (inosinic acid:cytidylic acid) and lactic acid markedly increased IL-8 production (5.0 ng/mL) and induced the release of IL-1beta (96.2 pg/mL).	Poly I	19-38	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
21934447-7	2011	The combination of poly (inosinic acid:cytidylic acid) and lactic acid markedly increased IL-8 production (5.0 ng/mL) and induced the release of IL-1beta (96.2 pg/mL).	Cytidine Monophosphate	39-53	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
21934447-8	2011	The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid.	Lactic Acid	49-60	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
21934447-7	2011	The combination of poly (inosinic acid:cytidylic acid) and lactic acid markedly increased IL-8 production (5.0 ng/mL) and induced the release of IL-1beta (96.2 pg/mL).	Lactic Acid	59-70	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
21934447-8	2011	The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid.	Lactic Acid	120-131	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
21934447-8	2011	The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid.	Acetic Acid	154-165	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
21934447-8	2011	The poly (inosinic acid:cytidylic acid)-mediated lactic acid effect on IL-1beta and IL-8 release was abrogated when the lactic acid was neutralized or if acetic acid was substituted for lactic acid.	Lactic Acid	120-131	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
27156875-4	2011	Fluorine-18-Sodium Fluoride (18F-NaF) positron emission tomography/computed tomography (PET/CT) imaging allows detection and quantification of arterial molecular calcification in heart and across multiple vessels.	fluorine-18-sodium fluoride	0-27	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
21587103-10	2011	RESULTS: In vitro, resveratrol exhibited an anti-inflammatory and anticatabolic effect on the messenger RNA and protein level for IL-6, IL-8, MMP1, MMP3 and MMP13.	Resveratrol	19-30	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
21514398-9	2011	Compared to placebo Bimosiamose reduced the numbers of sputum neutrophils by 40% (p = 0.068) and concentrations of interleukin-8 and matrix-metalloproteinase-9 in sputum supernatant by 35% (p = 0.004) and 46% (p = 0.022), respectively.	bimosiamose	20-31	C-X-C motif chemokine ligand 8	Homo sapiens	115-128
21821700-8	2011	Significant reduction of IL-8 levels (P &lt; 0.05) was seen in post-curcumin samples from patients with dental caries.	Curcumin	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
22321839-6	2011	And Group B at post-operation was lower than Group C ((147 +- 19) vs (212 +- 18), P &lt; 0.05); the pre-operative concentration of IL-8 was lowest in Group A ((85 +- 16) ng/L vs (151 +- 18) ng/L &amp; (164 +- 22) ng/L, P &lt; 0.05).	Adenosine Monophosphate	196-199	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
22321839-8	2011	There were significantly positive correlations between depression scores, the expression of CD(40) and the plasma concentration of IL-8.	Cadmium	92-94	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
21669195-3	2011	It was anticipated that PGP exerts its chemoatactic activity by mimicking key sequences found within classical neutrophil chemokines, such as CXCL8, and binding their receptors, CXCR1/2.	prolyl-glycyl-proline	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	142-147
21821055-0	2011	Dimethyl sulphoxide and dimethyl sulphone are potent inhibitors of IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2.	Dimethyl Sulfoxide	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
21821055-0	2011	Dimethyl sulphoxide and dimethyl sulphone are potent inhibitors of IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2.	dimethyl sulfone	24-41	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
21821055-8	2011	Long-term exposure of cells to DMSO (1%) or DMS (100mM) led to a dramatic downregulation of IL-6 and IL-8 expression which was accompanied by the deactivation of ERK1/2.	Dimethyl Sulfoxide	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
21821055-8	2011	Long-term exposure of cells to DMSO (1%) or DMS (100mM) led to a dramatic downregulation of IL-6 and IL-8 expression which was accompanied by the deactivation of ERK1/2.	dimethyl sulfone	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
21821055-10	2011	SIGNIFICANCE: In this study, we demonstrate that both DMSO and DMS represent strong anti-inflammatory properties by blocking constitutive as well as IL-1beta-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2.	Dimethyl Sulfoxide	54-58	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
21821055-10	2011	SIGNIFICANCE: In this study, we demonstrate that both DMSO and DMS represent strong anti-inflammatory properties by blocking constitutive as well as IL-1beta-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2.	dimethyl sulfone	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
21821700-9	2011	Although there was reduced IL-8 expression in 8 of 21 post-curcumin samples of HNSCC patients, the data did not reach statistical significance.	Curcumin	59-67	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
21670067-5	2011	Nonreduced mCRP was largely inert in activating human coronary artery endothelial cells (HCAECs), whereas reduced or cysteine-mutated mCRP evoked marked release of IL-8 and monocyte chemoattractant protein-1 from HCAECs, with ~50% increase at a concentration of 1 mug/ml.	Cysteine	117-125	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
21708216-3	2011	This study was undertaken to determine whether sodium fluoride (NaF) induces apoptosis in human oral cells and if so, whether Bad protein is involved in the process.	Sodium Fluoride	47-62	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
21684332-5	2011	Here we demonstrate that CS induces the release of CXCL-8 and IL-1beta from human bronchial epithelial cells (HBE-14o).	Cesium	25-27	C-X-C motif chemokine ligand 8	Homo sapiens	51-57
21684332-6	2011	CS-induced CXCL-8 production was inhibited by an antibody against TLR4 and by inhibitory ODN suggesting the involvement of TLR4 and TLR9.	Cesium	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	11-17
21800892-9	2011	Both undigested and digested PPP3 significantly reduced IL-8 secretion in H(2)O(2)-induced Caco-2 cells, indicating that antioxidative stress bioactivity is retained upon digestion.	Hydrogen Peroxide	74-82	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
21827134-4	2011	along with gonytolides B and C. Gonytolide A also increased TNF-alpha-stimulated production of IL-8 in human umbilical vein endothelial cells.	gonytolide A	32-44	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
21862816-3	2011	CONCLUSION: Skeletal imaging with (18)F-NaF harnesses both the superior imaging characteristics of PET and the improved biodistribution of the fluoride tracer in comparison with standard nuclear techniques, resulting in excellent-quality images that can effectively be used to investigate the cause of bone pain in children.	Fluorides	143-151	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
21684332-9	2011	The molecular mechanism of the CS-induced CXCL-8 production by the epithelial cells was further investigated.	Cesium	31-33	C-X-C motif chemokine ligand 8	Homo sapiens	42-48
21684332-11	2011	Interestingly, the inflammasome activator monosodium urate crystals (MSU) induced the release of CXCL-8 and IL-1beta and the caspase-1 inhibitor Z-VADDCB suppressed the CS-induced release of CXCL-8.	SODIUM URATE	42-67	C-X-C motif chemokine ligand 8	Homo sapiens	97-103
21684332-11	2011	Interestingly, the inflammasome activator monosodium urate crystals (MSU) induced the release of CXCL-8 and IL-1beta and the caspase-1 inhibitor Z-VADDCB suppressed the CS-induced release of CXCL-8.	SODIUM URATE	42-67	C-X-C motif chemokine ligand 8	Homo sapiens	191-197
21684332-11	2011	Interestingly, the inflammasome activator monosodium urate crystals (MSU) induced the release of CXCL-8 and IL-1beta and the caspase-1 inhibitor Z-VADDCB suppressed the CS-induced release of CXCL-8.	msu	69-72	C-X-C motif chemokine ligand 8	Homo sapiens	97-103
21684332-11	2011	Interestingly, the inflammasome activator monosodium urate crystals (MSU) induced the release of CXCL-8 and IL-1beta and the caspase-1 inhibitor Z-VADDCB suppressed the CS-induced release of CXCL-8.	msu	69-72	C-X-C motif chemokine ligand 8	Homo sapiens	191-197
21684332-11	2011	Interestingly, the inflammasome activator monosodium urate crystals (MSU) induced the release of CXCL-8 and IL-1beta and the caspase-1 inhibitor Z-VADDCB suppressed the CS-induced release of CXCL-8.	z-VAD-DCB	145-153	C-X-C motif chemokine ligand 8	Homo sapiens	191-197
21684332-11	2011	Interestingly, the inflammasome activator monosodium urate crystals (MSU) induced the release of CXCL-8 and IL-1beta and the caspase-1 inhibitor Z-VADDCB suppressed the CS-induced release of CXCL-8.	Cesium	169-171	C-X-C motif chemokine ligand 8	Homo sapiens	191-197
21684332-13	2011	In conclusion, our results demonstrate that CS releases CXCL-8 from HBE-14o cells via TLR4 and TLR9 and inflammasome activation.	Cesium	44-46	C-X-C motif chemokine ligand 8	Homo sapiens	56-62
21679760-6	2011	RESULTS: Sinomenine was found to significantly inhibit TNF-alpha induced cell surface expression of vascular cell adhesion molecule (VCAM)-1 and release of inflammatory cytokine and chemokine IL-6, CCL2 and CXCL8 from both normal and RA-FLS (all p&lt;0.05).	sinomenine	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	207-212
21571356-10	2011	L-glutathione reduced improved the downregulatory effects of FP on IKKalpha and IL-8 levels.	Glutathione	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
21142820-5	2011	Apigenin significantly inhibits the inductive effect of phorbol 12-myristate 13-acetate (PMA) plus A23187 on the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF).	Tetradecanoylphorbol Acetate	56-87	C-X-C motif chemokine ligand 8	Homo sapiens	193-211
21142820-5	2011	Apigenin significantly inhibits the inductive effect of phorbol 12-myristate 13-acetate (PMA) plus A23187 on the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF).	Calcimycin	99-105	C-X-C motif chemokine ligand 8	Homo sapiens	193-211
21660963-8	2011	SB-328437 also diminished neutrophil recruitment in alveolar airspaces and improved LPS-induced ALI and production of IL-8 in bronchoalveolar lavage fluid.	SB 328437	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
22072831-6	2011	Moreover, TvSP-induced IL-8 production was also significantly inhibited by pretreatment of neutrophils with ikappaB inhibitor or CREB inhibitor.	tvsp	10-14	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
21056929-6	2011	Both genistein and E(2) inhibited basal and cAMP-induced mRNA levels of endogenous estrogen responsive genes containing CRE/CRE-like elements in their promoter regions, including interleukin (IL) 8 and serum- and glucocorticoid-inducible kinase 1 (SGK1).	Genistein	5-14	C-X-C motif chemokine ligand 8	Homo sapiens	179-197
21056929-6	2011	Both genistein and E(2) inhibited basal and cAMP-induced mRNA levels of endogenous estrogen responsive genes containing CRE/CRE-like elements in their promoter regions, including interleukin (IL) 8 and serum- and glucocorticoid-inducible kinase 1 (SGK1).	Estradiol	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	179-197
21056929-6	2011	Both genistein and E(2) inhibited basal and cAMP-induced mRNA levels of endogenous estrogen responsive genes containing CRE/CRE-like elements in their promoter regions, including interleukin (IL) 8 and serum- and glucocorticoid-inducible kinase 1 (SGK1).	Cyclic AMP	44-48	C-X-C motif chemokine ligand 8	Homo sapiens	179-197
21056929-7	2011	Daidzein inhibited basal and cAMP-induced IL-8, but not SGK1 mRNA expression.	daidzein	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
21056929-7	2011	Daidzein inhibited basal and cAMP-induced IL-8, but not SGK1 mRNA expression.	Cyclic AMP	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
21976205-5	2011	An increase of IL-8 release could be determined at trichloramine concentrations higher than 10 mg/m(3) and an increase of IL-6 release at concentrations of 20 mg/m(3).	nitrogen chloride	51-64	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
21777978-0	2011	Arsenic increases lipopolysaccharide-dependent expression of interleukin-8 gene by stimulating a redox-sensitive pathway that strengthens p38-kinase activation.	Arsenic	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
21670847-9	2011	Our findings demonstrate an unequivocal role for MACs in angiogenesis, which is linked to paracrine release of cytokines such as IL-8.	macs	49-53	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
21777978-7	2011	ATO increases LPS-dependent expression of IL-8 by enhancing p38-kinase activity induced by LPS in U937 cells.	Arsenic Trioxide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
21777978-4	2011	In the present study, we determined molecular basis of arsenic trioxide (ATO) effects on LPS-dependent expression of interleukin-8 (IL-8) gene in human monocytic cells.	Arsenic Trioxide	55-71	C-X-C motif chemokine ligand 8	Homo sapiens	117-130
21777978-10	2011	In addition, it markedly prevents the increase of both p38-kinase phosphorylation and IL-8 gene expression in LPS-stimulated cells pre-treated with ATO.	Arsenic Trioxide	148-151	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
21777978-4	2011	In the present study, we determined molecular basis of arsenic trioxide (ATO) effects on LPS-dependent expression of interleukin-8 (IL-8) gene in human monocytic cells.	Arsenic Trioxide	55-71	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
21777978-11	2011	Finally, as observed with the metalloid, pre-treatment of U937 cells with hydrogen peroxide markedly increases LPS-dependent expression of IL-8 gene.	Hydrogen Peroxide	74-91	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
21777978-12	2011	In conclusion, our study demonstrates that ATO increases LPS-dependent expression of the inflammatory IL-8 gene by strengthening the p38 kinase activity induced by LPS through stimulation of a ROS/Src kinase signalling pathway.	Arsenic Trioxide	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
21777978-4	2011	In the present study, we determined molecular basis of arsenic trioxide (ATO) effects on LPS-dependent expression of interleukin-8 (IL-8) gene in human monocytic cells.	Arsenic Trioxide	73-76	C-X-C motif chemokine ligand 8	Homo sapiens	117-130
21777978-12	2011	In conclusion, our study demonstrates that ATO increases LPS-dependent expression of the inflammatory IL-8 gene by strengthening the p38 kinase activity induced by LPS through stimulation of a ROS/Src kinase signalling pathway.	Reactive Oxygen Species	193-196	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
21777978-4	2011	In the present study, we determined molecular basis of arsenic trioxide (ATO) effects on LPS-dependent expression of interleukin-8 (IL-8) gene in human monocytic cells.	Arsenic Trioxide	73-76	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
21777978-5	2011	Pre-treatment with non cytotoxic concentrations of ATO for 48h increase IL-8 gene expression induced by LPS in monocytic U937 cells and in some, but not all, primary cultures of blood monocytes.	Arsenic Trioxide	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
21777978-6	2011	Actinomycin D blocks induction of IL-8 mRNA levels in LPS-stimulated U937 cells pre-treated or not with ATO, which suggests that the metalloid strengthens LPS-dependent transcriptional regulation of IL-8 expression.	Dactinomycin	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
21777978-6	2011	Actinomycin D blocks induction of IL-8 mRNA levels in LPS-stimulated U937 cells pre-treated or not with ATO, which suggests that the metalloid strengthens LPS-dependent transcriptional regulation of IL-8 expression.	Dactinomycin	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
21637924-0	2011	Tetramethylpyrazine inhibits migration of SKOV3 human ovarian carcinoma cells and decreases the expression of interleukin-8 via the ERK1/2, p38 and AP-1 signaling pathways.	tetramethylpyrazine	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	110-123
21471847-0	2011	Interleukin-8 overexpression in astrocytomas is induced by prostaglandin E2 and is associated with the transcription factors CCAAT/enhancer-binding protein-beta and CCAAT/enhancer-binding homologous protein.	Dinoprostone	59-75	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
21471847-2	2011	OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis.	Dinoprostone	214-230	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
21471847-2	2011	OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis.	Dinoprostone	214-230	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
21471847-2	2011	OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis.	Dinoprostone	214-230	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
21471847-2	2011	OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis.	Dinoprostone	232-236	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
21471847-2	2011	OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis.	Dinoprostone	232-236	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
21471847-2	2011	OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis.	Dinoprostone	232-236	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
21471847-2	2011	OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis.	Dinoprostone	346-350	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
21471847-2	2011	OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis.	Dinoprostone	346-350	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
21471847-2	2011	OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis.	Dinoprostone	346-350	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
21471847-6	2011	PGE2-treated astroglioma cells showed a marked upregulation of IL-8, C/EBP-beta, and CHOP, as well as increased proliferation and decreased apoptosis compared with untreated cells.	Dinoprostone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
21637924-5	2011	The role of TMP in association with IL-8 in the tumor cell migratory process remains unclear.	tetramethylpyrazine	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
21637924-6	2011	The purpose of the present study was to determine whether TMP influences the migratory ability of a human ovarian carcinoma cell line (SKOV3) via regulation of IL-8 expression in vitro.	tetramethylpyrazine	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
21471847-9	2011	CONCLUSION: (1) PGE2 is responsible for IL-8 overexpression, independently of the malignancy grade, in astrogliomas only.	Dinoprostone	16-20	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
21637924-7	2011	Cell counts showed that treatment of SKOV3 with TMP (25-100 microg/ml) for 24 h did not decrease cell numbers, while an effect of TMP on the down-regulation of the expression of IL-8 was observed.	tetramethylpyrazine	130-133	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
21471847-10	2011	(2) C/EBP-beta and CHOP may be involved in mediating PGE2-induced IL-8 activation in these tumors.	Dinoprostone	53-57	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
21637924-8	2011	In addition, migration of SKOV3 cells was suppressed after treatment with TMP (25-100 microg/ml) for 24 h. Therefore, expression of IL-8 by SKOV3 cells correlates with their metastatic potential.	tetramethylpyrazine	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
21637924-10	2011	Furthermore, IL-8 mRNA expression was inhibited significantly after co-incubation with PD98059 (ERK inhibitor) and SB203580 (p38 inhibitor), respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	87-94	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
21637924-10	2011	Furthermore, IL-8 mRNA expression was inhibited significantly after co-incubation with PD98059 (ERK inhibitor) and SB203580 (p38 inhibitor), respectively.	SB 203580	115-123	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
21637924-12	2011	Our data suggest that TMP may inhibit tumor cell invasion and migration, at least in part, through its down-regulation of IL-8 expression.	tetramethylpyrazine	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
24900265-0	2011	Aryltriflates as a Neglected Moiety in Medicinal Chemistry: A Case Study from a Lead Optimization of CXCL8 Inhibitors.	aryltriflates	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	101-106
21623862-4	2011	DA-6034 significantly inhibited NF-kappaB activation and upregulated the expressions of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 in MKN-45 cells infected with H. pylori.	recoflavone	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
21623862-4	2011	DA-6034 significantly inhibited NF-kappaB activation and upregulated the expressions of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 in MKN-45 cells infected with H. pylori.	recoflavone	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
21623862-7	2011	Treatment with DA-6034 dissociated the Hsp90 and IKK-gamma complex in H. pylori-infected cells, leading to the inhibition of IL-8 expression.	recoflavone	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
21756928-8	2011	Both spontaneous and T/I-induced release of IL-8 and IP-10 was suppressed, although 50muM resveratrol and polydatin up-regulated IL-8.	Resveratrol	90-101	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
21756928-8	2011	Both spontaneous and T/I-induced release of IL-8 and IP-10 was suppressed, although 50muM resveratrol and polydatin up-regulated IL-8.	polydatin	106-115	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
21756928-9	2011	At this concentration, resveratrol activated both gene expression and de novo synthesis of IL-8 and AhR-mediated mechanisms were involved.	Resveratrol	23-34	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
21723850-8	2011	Treating CFBE41o(-) cells with the antioxidant glutathione rescued the IFRD1 protein level closer to control level and also reduced the pro-inflammatory cytokine IL-8 release.	Glutathione	47-58	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
21700386-1	2011	The presence of NaF in the aqueous suspension of TiO(2) can accelerate the photocatalytic degradation of organic pollutants.	titanium dioxide	49-55	C-X-C motif chemokine ligand 8	Homo sapiens	16-19
21715345-10	2011	A significant increase in expression levels of IL-6, TNF-alpha, IL-8, MCP-1, ICAM-1, and BFGF was observed after poly (I:C) RNA stimulation (P &lt; 0.05).	Poly I-C	113-123	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
21641110-1	2011	This study explored the possibility of recovering waste powder from photonic industry into two useful resources, sodium fluoride (NaF) and the silica precursor solution.	Sodium Fluoride	113-128	C-X-C motif chemokine ligand 8	Homo sapiens	130-133
21669297-7	2011	Three clusters of food, food animal and human NAP1 isolates were highly related by MLVA.	mlva	83-87	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
21692122-1	2011	Poly(anilineboronic acid) (PABA) nanofibers with U-shaped and ring-shaped morphologies have been synthesized successfully by chemical polymerization of 3-aminophenylboronic acid (APBA) in the presence of cetyltrimethylammonium bromide (CTAB) and NaF.	poly(anilineboronic acid)	0-25	C-X-C motif chemokine ligand 8	Homo sapiens	246-249
21692122-1	2011	Poly(anilineboronic acid) (PABA) nanofibers with U-shaped and ring-shaped morphologies have been synthesized successfully by chemical polymerization of 3-aminophenylboronic acid (APBA) in the presence of cetyltrimethylammonium bromide (CTAB) and NaF.	4-Aminobenzoic Acid	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	246-249
21707096-1	2011	Temperature dependence study of the self-diffusion coefficient of Cs(+) ion in dibenzo-18-crown-6 (DB18C6) modified Nafion-117 (Cs-Naf-CR) was carried out in the temperature range of 50-65  C. Temperature dependence of water diffusion in Cs-Naf-CR was also studied to understand the mechanism of cation and water transport in the membrane.	Cesium	66-68	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
21707096-1	2011	Temperature dependence study of the self-diffusion coefficient of Cs(+) ion in dibenzo-18-crown-6 (DB18C6) modified Nafion-117 (Cs-Naf-CR) was carried out in the temperature range of 50-65  C. Temperature dependence of water diffusion in Cs-Naf-CR was also studied to understand the mechanism of cation and water transport in the membrane.	Cesium	66-68	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
21707096-1	2011	Temperature dependence study of the self-diffusion coefficient of Cs(+) ion in dibenzo-18-crown-6 (DB18C6) modified Nafion-117 (Cs-Naf-CR) was carried out in the temperature range of 50-65  C. Temperature dependence of water diffusion in Cs-Naf-CR was also studied to understand the mechanism of cation and water transport in the membrane.	dibenzo-18-crown-6	79-97	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
21707096-1	2011	Temperature dependence study of the self-diffusion coefficient of Cs(+) ion in dibenzo-18-crown-6 (DB18C6) modified Nafion-117 (Cs-Naf-CR) was carried out in the temperature range of 50-65  C. Temperature dependence of water diffusion in Cs-Naf-CR was also studied to understand the mechanism of cation and water transport in the membrane.	dibenzo-18-crown-6	79-97	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
21707096-1	2011	Temperature dependence study of the self-diffusion coefficient of Cs(+) ion in dibenzo-18-crown-6 (DB18C6) modified Nafion-117 (Cs-Naf-CR) was carried out in the temperature range of 50-65  C. Temperature dependence of water diffusion in Cs-Naf-CR was also studied to understand the mechanism of cation and water transport in the membrane.	dibenzo-18-crown-6	99-105	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
21707096-1	2011	Temperature dependence study of the self-diffusion coefficient of Cs(+) ion in dibenzo-18-crown-6 (DB18C6) modified Nafion-117 (Cs-Naf-CR) was carried out in the temperature range of 50-65  C. Temperature dependence of water diffusion in Cs-Naf-CR was also studied to understand the mechanism of cation and water transport in the membrane.	dibenzo-18-crown-6	99-105	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
21707096-1	2011	Temperature dependence study of the self-diffusion coefficient of Cs(+) ion in dibenzo-18-crown-6 (DB18C6) modified Nafion-117 (Cs-Naf-CR) was carried out in the temperature range of 50-65  C. Temperature dependence of water diffusion in Cs-Naf-CR was also studied to understand the mechanism of cation and water transport in the membrane.	nafion-117	116-126	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
21707096-1	2011	Temperature dependence study of the self-diffusion coefficient of Cs(+) ion in dibenzo-18-crown-6 (DB18C6) modified Nafion-117 (Cs-Naf-CR) was carried out in the temperature range of 50-65  C. Temperature dependence of water diffusion in Cs-Naf-CR was also studied to understand the mechanism of cation and water transport in the membrane.	Cesium	128-130	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
21707096-1	2011	Temperature dependence study of the self-diffusion coefficient of Cs(+) ion in dibenzo-18-crown-6 (DB18C6) modified Nafion-117 (Cs-Naf-CR) was carried out in the temperature range of 50-65  C. Temperature dependence of water diffusion in Cs-Naf-CR was also studied to understand the mechanism of cation and water transport in the membrane.	Cesium	128-130	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
21707096-1	2011	Temperature dependence study of the self-diffusion coefficient of Cs(+) ion in dibenzo-18-crown-6 (DB18C6) modified Nafion-117 (Cs-Naf-CR) was carried out in the temperature range of 50-65  C. Temperature dependence of water diffusion in Cs-Naf-CR was also studied to understand the mechanism of cation and water transport in the membrane.	Chromium	135-137	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
21707096-1	2011	Temperature dependence study of the self-diffusion coefficient of Cs(+) ion in dibenzo-18-crown-6 (DB18C6) modified Nafion-117 (Cs-Naf-CR) was carried out in the temperature range of 50-65  C. Temperature dependence of water diffusion in Cs-Naf-CR was also studied to understand the mechanism of cation and water transport in the membrane.	Chromium	135-137	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
21707096-1	2011	Temperature dependence study of the self-diffusion coefficient of Cs(+) ion in dibenzo-18-crown-6 (DB18C6) modified Nafion-117 (Cs-Naf-CR) was carried out in the temperature range of 50-65  C. Temperature dependence of water diffusion in Cs-Naf-CR was also studied to understand the mechanism of cation and water transport in the membrane.	Cesium	128-130	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
21707096-1	2011	Temperature dependence study of the self-diffusion coefficient of Cs(+) ion in dibenzo-18-crown-6 (DB18C6) modified Nafion-117 (Cs-Naf-CR) was carried out in the temperature range of 50-65  C. Temperature dependence of water diffusion in Cs-Naf-CR was also studied to understand the mechanism of cation and water transport in the membrane.	Cesium	128-130	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
21707096-2	2011	Because of the very slow kinetics of isotopic exchange, self-diffusion measurement of Na(+) in Na-Naf-CR was carried out only at 60  C. The result indicates that self-diffusion behavior is governed by the nature of the cation in which the crown ether was loaded in the membrane matrix.	Ether	245-250	C-X-C motif chemokine ligand 8	Homo sapiens	98-101
21707096-3	2011	The activation energy of diffusion for Cs(+) ion and water in Cs-Naf-CR was found to be much higher than that in the pure Cs(+) form of Nafion (Cs-Naf).	Cesium	39-41	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
21707096-3	2011	The activation energy of diffusion for Cs(+) ion and water in Cs-Naf-CR was found to be much higher than that in the pure Cs(+) form of Nafion (Cs-Naf).	Cesium	39-41	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
21707096-3	2011	The activation energy of diffusion for Cs(+) ion and water in Cs-Naf-CR was found to be much higher than that in the pure Cs(+) form of Nafion (Cs-Naf).	Water	53-58	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
21707096-3	2011	The activation energy of diffusion for Cs(+) ion and water in Cs-Naf-CR was found to be much higher than that in the pure Cs(+) form of Nafion (Cs-Naf).	Water	53-58	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
21636531-5	2011	Interleukin-8 (IL-8) secreted by Het1A cells upon stimulation by capsaicin or acid with/without 4-hydroxy-2-nonenal (HNE) was measured by ELISA.	Capsaicin	65-74	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
21636531-5	2011	Interleukin-8 (IL-8) secreted by Het1A cells upon stimulation by capsaicin or acid with/without 4-hydroxy-2-nonenal (HNE) was measured by ELISA.	Capsaicin	65-74	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
21636531-5	2011	Interleukin-8 (IL-8) secreted by Het1A cells upon stimulation by capsaicin or acid with/without 4-hydroxy-2-nonenal (HNE) was measured by ELISA.	4-hydroxy-2-nonenal	96-115	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
21636531-5	2011	Interleukin-8 (IL-8) secreted by Het1A cells upon stimulation by capsaicin or acid with/without 4-hydroxy-2-nonenal (HNE) was measured by ELISA.	4-hydroxy-2-nonenal	96-115	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
21636531-8	2011	Capsaicin and acid induced IL-8 production in Het1A cells, and this production was diminished by antagonists of TRPV1.	Capsaicin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
21636531-10	2011	Moreover, IL-8 production in capsaicin-stimulated Het1A cells was enhanced by synthetic HNE treatment.	Capsaicin	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
21640702-4	2011	Activation of AhR in vitro by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced IL-8 expression in MDA-MB 436 and MCF-7 cells in an AhR and RelB dependent manner.	Polychlorinated Dibenzodioxins	30-65	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
21640702-4	2011	Activation of AhR in vitro by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced IL-8 expression in MDA-MB 436 and MCF-7 cells in an AhR and RelB dependent manner.	Polychlorinated Dibenzodioxins	67-71	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
21707096-3	2011	The activation energy of diffusion for Cs(+) ion and water in Cs-Naf-CR was found to be much higher than that in the pure Cs(+) form of Nafion (Cs-Naf).	Cesium	62-64	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
21707096-3	2011	The activation energy of diffusion for Cs(+) ion and water in Cs-Naf-CR was found to be much higher than that in the pure Cs(+) form of Nafion (Cs-Naf).	Cesium	62-64	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
21707096-3	2011	The activation energy of diffusion for Cs(+) ion and water in Cs-Naf-CR was found to be much higher than that in the pure Cs(+) form of Nafion (Cs-Naf).	Chromium	69-71	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
21707096-3	2011	The activation energy of diffusion for Cs(+) ion and water in Cs-Naf-CR was found to be much higher than that in the pure Cs(+) form of Nafion (Cs-Naf).	Chromium	69-71	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
21707096-3	2011	The activation energy of diffusion for Cs(+) ion and water in Cs-Naf-CR was found to be much higher than that in the pure Cs(+) form of Nafion (Cs-Naf).	Cesium	62-64	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
21707096-3	2011	The activation energy of diffusion for Cs(+) ion and water in Cs-Naf-CR was found to be much higher than that in the pure Cs(+) form of Nafion (Cs-Naf).	Cesium	62-64	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
21707096-3	2011	The activation energy of diffusion for Cs(+) ion and water in Cs-Naf-CR was found to be much higher than that in the pure Cs(+) form of Nafion (Cs-Naf).	perfluorosulfonic acid	136-142	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
21707096-3	2011	The activation energy of diffusion for Cs(+) ion and water in Cs-Naf-CR was found to be much higher than that in the pure Cs(+) form of Nafion (Cs-Naf).	Cesium	62-64	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
21707096-3	2011	The activation energy of diffusion for Cs(+) ion and water in Cs-Naf-CR was found to be much higher than that in the pure Cs(+) form of Nafion (Cs-Naf).	Cesium	62-64	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
21707096-4	2011	Water uptake of the membrane was also found to have reduced compared to Cs/Na-Naf.	Cesium	72-74	C-X-C motif chemokine ligand 8	Homo sapiens	78-81
21531456-8	2011	HT1080 cells treated with Ad/CD-PEG(500)-RGD showed strong induction of apoptosis and suppression of IL-8 and VEGF expression as well.	cd-peg	29-35	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
21554996-3	2011	Therefore, the current study was aimed to prospectively utilize the baseline IL-8 levels in the HCV infected serum and predicts its role in sustained virological response (SVR) to IFN-alpha+ribavirin therapy, in chronic HCV patients in Pakistan.	Ribavirin	190-199	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
20607595-5	2011	The ex vivo release of IL-1beta and IL-6 was not altered by simvastatin, whereas the release of TNF-alpha and IL-8 increased after 6 weeks of simvastatin treatment.	Simvastatin	142-153	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
21554996-10	2011	Results of this study suggest that increased levels of IL-8 in HCV infection might be involved in pathogenesis, persistence and resistance to IFN-alpha+ribavirin combination therapy.	Ribavirin	152-161	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
21762159-5	2011	o-Cymen-5-ol and zinc chloride have been incorporated into a sodium fluoride (NaF)/silica toothpaste at 0.1%w/w and 0.6%w/w respectively to provide additional benefits.	o-cymen-5-ol	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	78-81
21567070-11	2011	We demonstrated that prophylactic use of sivelestat mitigated bronchial inflammation by suppressing NE activity and IL-8 levels in the ELF and shortened the duration of SIRS after transthoracic esophagectomy.	sivelestat	41-51	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
21762159-5	2011	o-Cymen-5-ol and zinc chloride have been incorporated into a sodium fluoride (NaF)/silica toothpaste at 0.1%w/w and 0.6%w/w respectively to provide additional benefits.	Sodium Fluoride	61-76	C-X-C motif chemokine ligand 8	Homo sapiens	78-81
21643893-5	2011	After the inflammatory human bronchial epithelial cell line BEAS-2B was treated with dehydroepiandrosterone, levels of proinflammatory cytokines and chemokines were inhibited, including IL-6, IL-8, CCL11, and CCL24.	Dehydroepiandrosterone	85-107	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
21471820-12	2011	CONCLUSIONS: Our data suggest divergent effects of tenofovir and AZT on proinflammatory responses in monocytes (CCL3 and IL-8) and PBMCs (CCL3).	Tenofovir	51-60	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
21471820-12	2011	CONCLUSIONS: Our data suggest divergent effects of tenofovir and AZT on proinflammatory responses in monocytes (CCL3 and IL-8) and PBMCs (CCL3).	Zidovudine	65-68	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
21570715-9	2011	IL-8 production by macrophages in response to hyaluronan fragment stimulation was compared.	Hyaluronic Acid	46-56	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
21570715-13	2011	Macrophages from subjects with asthma showed an increase in responsiveness to low-molecular-weight hyaluronan stimulation, as demonstrated by increased IL-8 production.	Hyaluronic Acid	99-109	C-X-C motif chemokine ligand 8	Homo sapiens	152-156
21752043-0	2011	Porphyromonas gingivalis lipopolysaccharide lipid A heterogeneity differentially modulates the expression of IL-6 and IL-8 in human gingival fibroblasts.	Lipid A	44-51	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
21695777-9	2011	The well-dispersed nano-CaF2 may be expected to be a more effective anticaries agent than NaF by providing longer lasting elevations of fluoride concentrations in oral fluids.	Fluorides	136-144	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
21555999-0	2011	Hydrogen sulfide inhibits IL-8 expression in human keratinocytes via MAP kinase signaling.	Hydrogen Sulfide	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
22103212-3	2011	The nanotube oxide layers were formed on Ti-35Ta-xHf alloy by anodic oxidation method in 1 M H3PO4 electrolytes containing 0.5 wt.% NaF and 0.8 wt.% NaF at room temperature.	Oxides	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	149-152
22103212-5	2011	The nano-porous surface of Ti-35Ta-xHf alloys showed in 0.5 wt% NaF solution and nanotubular surface showed in 0.8 wt% NaF solution, respectively.	ti-35ta-xhf	27-38	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
22103212-6	2011	The highly ordered nanotube layer without regular knots was formed on the Ti-35Ta-15Hf alloy in the 0.5 wt% NaF solution compared to on Ti-35Ta-3Hf and Ti-35Ta-7Hf alloys in 0.8 wt% NaF solution.	ti-35ta-15hf	74-86	C-X-C motif chemokine ligand 8	Homo sapiens	108-111
22103213-4	2011	Ti oxide nanotubes were formed on the Ti-35Ta-xZr alloys by anodizing in H3PO4 containing 0.8 wt% NaF solution at 25 degrees C. Anodization was carried out using a scanning potentiostat.	titanium dioxide	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	98-101
21555999-5	2011	Here, we demonstrate both in vitro and in vivo on primary psoriatic lesions that pharmacological inhibitors of ERKs as well as hydrogen sulfide not only reduce the basal expression and secretion of IL-8, but also interfere with IL-17- and IL-22-induced IL-8 production.	Hydrogen Sulfide	127-143	C-X-C motif chemokine ligand 8	Homo sapiens	198-202
21555999-5	2011	Here, we demonstrate both in vitro and in vivo on primary psoriatic lesions that pharmacological inhibitors of ERKs as well as hydrogen sulfide not only reduce the basal expression and secretion of IL-8, but also interfere with IL-17- and IL-22-induced IL-8 production.	Hydrogen Sulfide	127-143	C-X-C motif chemokine ligand 8	Homo sapiens	253-257
21651918-13	2011	Moreover, reduction in the levels of IL-6, IL-1Ra, MCP-1/CCL2 and IL-8/CXCL8 was observed in the presence of APE1 Glu allele in BM patients.	Glutamic Acid	114-117	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
21471820-7	2011	RESULTS: Tenofovir decreased and AZT increased both IL-8 and CCL3 production from monocytes after stimulation with TLR ligands, tumor necrosis factor-alpha, or live pathogens.	Zidovudine	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
21651918-13	2011	Moreover, reduction in the levels of IL-6, IL-1Ra, MCP-1/CCL2 and IL-8/CXCL8 was observed in the presence of APE1 Glu allele in BM patients.	Glutamic Acid	114-117	C-X-C motif chemokine ligand 8	Homo sapiens	71-76
21473897-3	2011	In this in vitro study, we found that nickel, as nickel chloride, could significantly enhance the invasive potential of human lung cancer cells, accompanied by elevated expression of IL-8, TGF-beta, MMP2 and MMP9 in human lung cancer cells.	nickel chloride	49-64	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
21830898-10	2011	The novel intervention strategies being developed for EPA and RA, such as IL-6 and IL-8 signaling blockade, may also be considered for chronic CHIKV arthritis.	Eicosapentaenoic Acid	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
21518732-11	2011	Furthermore, GSH-EE attenuated Deltapsi(m) depolarization and restored normal IL-8 secretion by CFTR-defective cells.	Glutathione	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
21621609-9	2011	In addition, supplementation with reduced GSH inhibited ozone-induced ROS production, NF-kappaB activation, and IL-8 production.	Glutathione	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
21621609-10	2011	Taken together, GSTM1 deficiency enhances ozone-induced IL-8 production, which is mediated by generated ROS and subsequent NF-kappaB activation in human bronchial epithelial cells.	Reactive Oxygen Species	104-107	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
21670316-8	2011	Likewise, both human blood neutrophils and neutrophil-like HL60 cells produced IL-8 in response to exogenous nucleotides, ATP being the most potent inducer.	Adenosine Triphosphate	122-125	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
21643604-4	2011	Finally, almost pure cBN (~90%) crystals are obtained by reacting NH(4)BF(4) and NaN(3) at 250  C and 450 MPa for 24 h, with NaF as the structural induction material.	cbn	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	125-128
21847358-4	2011	The coculture of PDAC and CAF cell lines enhanced the levels of inflammatory factors including IL-1alpha, IL-6, CXCL8, VEGF-A, CCL20, and COX-2.	pdac	17-21	C-X-C motif chemokine ligand 8	Homo sapiens	112-117
21675704-4	2011	Exposure of BEAS-2B and HBE to BaP caused epithelial cells to produce inflammatory cytokines IL-8, which subsequently induced BSMC proliferation and migration.	Benzo(a)pyrene	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
21473897-3	2011	In this in vitro study, we found that nickel, as nickel chloride, could significantly enhance the invasive potential of human lung cancer cells, accompanied by elevated expression of IL-8, TGF-beta, MMP2 and MMP9 in human lung cancer cells.	Nickel	38-44	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
21615439-7	2011	In ex vivo/in vitro studies, bile acids stimulated squamous oesophageal cells and Barrett"s epithelial cells to produce inflammatory mediators (e.g., IL-8 and COX-2) and caused oxidative stress, DNA damage and apoptosis.	Bile Acids and Salts	29-39	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
21489599-9	2011	The DeltapH(NaF) was likely a better indicator of the soil"s sulfate adsorption capacity than pH(NaF) as the former excludes the effect of soil acidity.	Sulfates	61-68	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
20870895-13	2011	The NF-kappaB inhibitors gliotoxin and parthenolide increased apoptosis and decreased IL-8 and CXCR2 expression.	Gliotoxin	25-34	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
20870895-13	2011	The NF-kappaB inhibitors gliotoxin and parthenolide increased apoptosis and decreased IL-8 and CXCR2 expression.	parthenolide	39-51	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
20870895-14	2011	Also, the p38MAPK inhibitor SB202190 increased apoptosis and decreased IL-8 expression but had no effect on CXCR2 expression.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
21143697-4	2011	We show that upregulation of the two NF-kB target genes show differences in pH preference, with IL-8 being preferentially upregulated by DCA at neutral pH, and IkB being upregulated by neutral DCA, acidic DCA, and acid alone.	Dichloroacetic Acid	137-140	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
21143697-4	2011	We show that upregulation of the two NF-kB target genes show differences in pH preference, with IL-8 being preferentially upregulated by DCA at neutral pH, and IkB being upregulated by neutral DCA, acidic DCA, and acid alone.	Dichloroacetic Acid	193-196	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
21143697-4	2011	We show that upregulation of the two NF-kB target genes show differences in pH preference, with IL-8 being preferentially upregulated by DCA at neutral pH, and IkB being upregulated by neutral DCA, acidic DCA, and acid alone.	Dichloroacetic Acid	193-196	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
21307878-6	2011	In the human T-cell line, MOLT-14, GM-CSF and IL-8 transcripts were increased and stabilized in cells treated with crude APP or purified procyanidins.	app	121-124	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
22435021-8	2011	On the contrary both LPS and CoCl(2) increased significantly IL-8.	cobaltous chloride	29-36	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
21765609-0	2011	Relationship between dietary folate intake and plasma monocyte chemoattractant protein-1 and interleukin-8 in heart failure patients.	Folic Acid	29-35	C-X-C motif chemokine ligand 8	Homo sapiens	93-106
21765609-8	2011	Dietary folate intake was found as a primary influencing factor on plasma levels of monocyte chemoattractant protein-1 (p&lt;0.005, R(2) = 0.20) and interleukin-8 (p&lt;0.001, R(2) = 0.32) through a stepwise multiple linear regression analysis.	Folic Acid	8-14	C-X-C motif chemokine ligand 8	Homo sapiens	149-162
21765609-9	2011	Dietary folate intake was significantly associated with plasma levels of monocyte chemoattractant protein-1 and interleukin-8 which indicates dietary folate may have a potentially beneficial role in the prevention and treatment of heart failure.	Folic Acid	8-14	C-X-C motif chemokine ligand 8	Homo sapiens	112-125
21765609-9	2011	Dietary folate intake was significantly associated with plasma levels of monocyte chemoattractant protein-1 and interleukin-8 which indicates dietary folate may have a potentially beneficial role in the prevention and treatment of heart failure.	Folic Acid	150-156	C-X-C motif chemokine ligand 8	Homo sapiens	112-125
21307878-6	2011	In the human T-cell line, MOLT-14, GM-CSF and IL-8 transcripts were increased and stabilized in cells treated with crude APP or purified procyanidins.	Proanthocyanidins	137-149	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
21623439-2	2011	Here, we report a one-pot synthesis of doxorubicin-doped silica nanoparticles (Dox/SiNPs) by using sodium fluoride (NaF) catalyzed hydrolysis of tetraethyl orthosilicate in a water-in-oil microemulsion.	Doxorubicin	39-50	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
21623439-2	2011	Here, we report a one-pot synthesis of doxorubicin-doped silica nanoparticles (Dox/SiNPs) by using sodium fluoride (NaF) catalyzed hydrolysis of tetraethyl orthosilicate in a water-in-oil microemulsion.	Silicon Dioxide	57-63	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
21623439-2	2011	Here, we report a one-pot synthesis of doxorubicin-doped silica nanoparticles (Dox/SiNPs) by using sodium fluoride (NaF) catalyzed hydrolysis of tetraethyl orthosilicate in a water-in-oil microemulsion.	Doxorubicin	79-82	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
21623439-2	2011	Here, we report a one-pot synthesis of doxorubicin-doped silica nanoparticles (Dox/SiNPs) by using sodium fluoride (NaF) catalyzed hydrolysis of tetraethyl orthosilicate in a water-in-oil microemulsion.	sinps	83-88	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
21623439-2	2011	Here, we report a one-pot synthesis of doxorubicin-doped silica nanoparticles (Dox/SiNPs) by using sodium fluoride (NaF) catalyzed hydrolysis of tetraethyl orthosilicate in a water-in-oil microemulsion.	Sodium Fluoride	99-114	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
21623439-2	2011	Here, we report a one-pot synthesis of doxorubicin-doped silica nanoparticles (Dox/SiNPs) by using sodium fluoride (NaF) catalyzed hydrolysis of tetraethyl orthosilicate in a water-in-oil microemulsion.	tetraethoxysilane	145-169	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
21623439-2	2011	Here, we report a one-pot synthesis of doxorubicin-doped silica nanoparticles (Dox/SiNPs) by using sodium fluoride (NaF) catalyzed hydrolysis of tetraethyl orthosilicate in a water-in-oil microemulsion.	Water	175-180	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
21623439-2	2011	Here, we report a one-pot synthesis of doxorubicin-doped silica nanoparticles (Dox/SiNPs) by using sodium fluoride (NaF) catalyzed hydrolysis of tetraethyl orthosilicate in a water-in-oil microemulsion.	Oils	184-187	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
21338276-5	2011	The most important findings were: (i) TTA reduced plasma total cholesterol, non HDL-cholesterol, LDL/HDL cholesterol ratio, triglycerides and total fatty acids; (ii) TTA decreased plasma TNF-alpha, IL-8 and VCAM-1; and (iii) plasma fatty acid composition changed with an increased level of monounsaturated fatty acids and decreased n-3 polyunsaturated fatty acids.	1-(carboxymethylthio)tetradecane	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	198-202
21338276-5	2011	The most important findings were: (i) TTA reduced plasma total cholesterol, non HDL-cholesterol, LDL/HDL cholesterol ratio, triglycerides and total fatty acids; (ii) TTA decreased plasma TNF-alpha, IL-8 and VCAM-1; and (iii) plasma fatty acid composition changed with an increased level of monounsaturated fatty acids and decreased n-3 polyunsaturated fatty acids.	1-(carboxymethylthio)tetradecane	166-169	C-X-C motif chemokine ligand 8	Homo sapiens	198-202
21899065-6	2011	In Group 1, wiferon produced an immunomodulatory effect, by lowering IL-8 concentrations to the level observed in Group 3.	wiferon	12-19	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
21486191-9	2011	The hydrolysis was catalyzed by plasma esterase because NaF (sodium fluoride: a general esterase inhibitor) inhibited WS070117 hydrolysis and metabolite production.	Sodium Fluoride	61-76	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
21385008-5	2011	Moreover, PL induced a strong cell actin cytoskeletal re-organization that persisted up to 24 h. The accelerated wound closure promoted by PL, in either presence or absence of serum, was associated with a high expression of the inflammatory cytokine interleukin-8.	pl	10-12	C-X-C motif chemokine ligand 8	Homo sapiens	250-263
21385008-5	2011	Moreover, PL induced a strong cell actin cytoskeletal re-organization that persisted up to 24 h. The accelerated wound closure promoted by PL, in either presence or absence of serum, was associated with a high expression of the inflammatory cytokine interleukin-8.	pl	139-141	C-X-C motif chemokine ligand 8	Homo sapiens	250-263
21385008-6	2011	Further, after 24 h PL treatment, confluent keratinocytes also expressed low amounts of interleukin-8 and of the antimicrobial peptide neutrophil gelatinase-associated lipocalin, which dramatically increased under inflammatory conditions.	pl	20-22	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
21486191-9	2011	The hydrolysis was catalyzed by plasma esterase because NaF (sodium fluoride: a general esterase inhibitor) inhibited WS070117 hydrolysis and metabolite production.	O2',O3',O5'-triacetyl-N6-(3-hydroxylaniline)adenosine	118-126	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
21666550-5	2011	Two major lignans, schizandrin (Sch) and gomisin A (Gom A), were identified and shown to induce interleukin (IL)-8, macrophage inflammatory protein-1beta (MIP-1beta), and granulocyte-macrophage-colony stimulating factor (GM-CSF) release by THP-1 cells.	Lignans	10-17	C-X-C motif chemokine ligand 8	Homo sapiens	96-114
21621513-6	2011	Furthermore, pretreatment with casuarinin decreased TNF-alpha-induced pro-inflammatory mediators, such as IL-1beta, IL-6, IL-8, and MCP-1.	casuarinin	31-41	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
21666550-5	2011	Two major lignans, schizandrin (Sch) and gomisin A (Gom A), were identified and shown to induce interleukin (IL)-8, macrophage inflammatory protein-1beta (MIP-1beta), and granulocyte-macrophage-colony stimulating factor (GM-CSF) release by THP-1 cells.	schizandrin	19-30	C-X-C motif chemokine ligand 8	Homo sapiens	96-114
21666550-5	2011	Two major lignans, schizandrin (Sch) and gomisin A (Gom A), were identified and shown to induce interleukin (IL)-8, macrophage inflammatory protein-1beta (MIP-1beta), and granulocyte-macrophage-colony stimulating factor (GM-CSF) release by THP-1 cells.	schizandrin	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	96-114
21474440-3	2011	In the absence of glucocorticoids, both decreasing GR protein levels by an siRNA strategy and results with the GR antagonist RU486 suggest a role for the unliganded GR in reduction of TNFalpha-induced IL-6 and IL-8 mRNA levels in End1/E6E7 cells.	Mifepristone	125-130	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
21666550-5	2011	Two major lignans, schizandrin (Sch) and gomisin A (Gom A), were identified and shown to induce interleukin (IL)-8, macrophage inflammatory protein-1beta (MIP-1beta), and granulocyte-macrophage-colony stimulating factor (GM-CSF) release by THP-1 cells.	schizandrol B	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	96-114
21666550-5	2011	Two major lignans, schizandrin (Sch) and gomisin A (Gom A), were identified and shown to induce interleukin (IL)-8, macrophage inflammatory protein-1beta (MIP-1beta), and granulocyte-macrophage-colony stimulating factor (GM-CSF) release by THP-1 cells.	schizandrol B	52-57	C-X-C motif chemokine ligand 8	Homo sapiens	96-114
21330456-0	2011	Nebulized hypertonic saline decreases IL-8 in sputum of patients with cystic fibrosis.	hypertonic	10-20	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
21330456-0	2011	Nebulized hypertonic saline decreases IL-8 in sputum of patients with cystic fibrosis.	Sodium Chloride	21-27	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
21330456-2	2011	IL-8 is protected from proteolytic degradation in the airways by binding to glycosaminoglycans, while remaining active.	Glycosaminoglycans	76-94	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
21330456-3	2011	Evidence that increased hypertonicity of airway secretions induced by hypertonic saline treatment alters levels of IL-8 is lacking.	Sodium Chloride	81-87	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
21330456-4	2011	OBJECTIVES: To investigate the antiinflammatory effect of hypertonic saline (HTS) treatment within the CF lung by focusing on IL-8.	Sodium Chloride	58-75	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
21330456-9	2011	High sodium concentrations also liberate IL-8 in CF BALF in vitro, and in vivo in CF sputum from patients receiving aerosolized HTS, resulting in degradation of IL-8 and decreased neutrophil chemotactic efficiency.	Sodium	5-11	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
21330456-9	2011	High sodium concentrations also liberate IL-8 in CF BALF in vitro, and in vivo in CF sputum from patients receiving aerosolized HTS, resulting in degradation of IL-8 and decreased neutrophil chemotactic efficiency.	Sodium	5-11	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
21330456-10	2011	CONCLUSIONS: Glycosaminoglycans possess the ability to influence the chemokine profile of the CF lung by binding and stabilizing IL-8, which promotes neutrophil chemotaxis and activation.	Glycosaminoglycans	13-31	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
21330456-11	2011	Nebulized hypertonic saline treatment disrupts the interaction between glycosaminoglycans and IL-8, rendering IL-8 susceptible to proteolytic degradation with subsequent decrease in neutrophil chemotaxis, thereby facilitating resolution of inflammation.	Sodium Chloride	21-27	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
21330456-11	2011	Nebulized hypertonic saline treatment disrupts the interaction between glycosaminoglycans and IL-8, rendering IL-8 susceptible to proteolytic degradation with subsequent decrease in neutrophil chemotaxis, thereby facilitating resolution of inflammation.	Sodium Chloride	21-27	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
21337319-8	2011	Stimulation with poly(I-C) induced the activation of IFN regulatory factor 3 (IRF-3), NF-kappaB, and activator protein 1 (AP-1) c-Jun as well as the subsequent production of IFNbeta, CXCL8, and MMP-3.	Poly I-C	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	183-188
21421269-5	2011	Beta-TCP 1 mum did not induce any cytokine after 6 h but slightly increases TNF-alpha, IL-1beta and IL-8 release after 18 h. Larger particles (32 and 40 mum) consistently caused higher levels of cytokine release by increasing the fraction of cytokine producing monocytes.	beta-tricalcium phosphate	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
21272678-12	2011	In human mononuclear leukocyte, isoforskolin (50, 100, and 200 muM) and dexamethasone (10 muM) pre-incubation lowered lipopolysaccharide (2 mug/mL) induced secretion of the cytokine TNF-alpha, and interleukins (IL)-1beta, IL-6, and IL-8.	Dexamethasone	72-85	C-X-C motif chemokine ligand 8	Homo sapiens	232-236
21420233-6	2011	This results in combinatorial inhibition of NFkappaB activity by gallic acid, which results in potent inhibition of NFkappaB target genes involved in inflammation, metastasis, anti-apoptosis and angiogenesis, such as IL-6, IL-8, COX2, CXCR4, XIAP, bcl2, VEGF.	Gallic Acid	65-76	C-X-C motif chemokine ligand 8	Homo sapiens	223-227
21631990-13	2011	The reduction of VCAM-1, resulting from increased IL-8, could be blocked by the MEK inhibitor, PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	95-102	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
21143185-4	2011	There is recent evidence that the NF-kappaB-dependent gene expression of interleukin 8, interleukin 6, cyclooxygenase-2, tumor necrosis factor and interleukin 33 in directly irradiated cells produced the cytokines and prostaglandin E2 with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB-dependent gene expression in bystander cells.	Dinoprostone	218-234	C-X-C motif chemokine ligand 8	Homo sapiens	73-86
21376115-5	2011	Removal of intracellular ROS by N-acetylcysteine reduced the AMPK activation and IL-8 induction.	Reactive Oxygen Species	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
21376115-5	2011	Removal of intracellular ROS by N-acetylcysteine reduced the AMPK activation and IL-8 induction.	Acetylcysteine	32-48	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
21376115-7	2011	Abrogation of the activation of NF-kappaB and STAT3 by BAY11-7085 and AG490, respectively, attenuated the IL-8 induction.	BAY 11-7085	55-65	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
21376115-7	2011	Abrogation of the activation of NF-kappaB and STAT3 by BAY11-7085 and AG490, respectively, attenuated the IL-8 induction.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	70-75	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
21376115-9	2011	Thus, a novel NADPH oxidase-dependent, ROS-sensitive AMPK signaling is important for CS-induced IL-8 production in LECs and possibly lung inflammation.	Reactive Oxygen Species	39-42	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
21376115-9	2011	Thus, a novel NADPH oxidase-dependent, ROS-sensitive AMPK signaling is important for CS-induced IL-8 production in LECs and possibly lung inflammation.	Cesium	85-87	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
20626232-8	2011	In addition, MW attenuated the PMACI-stimulated expression of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta (IL-1beta), IL-6, and IL-8 in human mast cells.	pmaci	31-36	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
21272678-13	2011	In conclusion, pretreatment with isoforskolin attenuates lipopolysaccharide-induced acute lung injury in several models, and it is involved in down-regulation of inflammatory responses and proinflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-8.	Isoforskolin	33-45	C-X-C motif chemokine ligand 8	Homo sapiens	246-250
21524887-8	2011	When NHK was stimulated by TGF-beta1, paraformaldehyde-fixed, and co-cultured with THP-1 cells, IL-8 production by THP-1 cells was increased compared to THP-1 cells only.	paraform	38-54	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
21427353-4	2011	When exposed to PAM at 10 microM, NHOK, not NHOF, underwent senescence: NHOK overexpressed senescence-associated beta-galactosidase (SA-beta-Gal), p16INK4A, IL-6, and IL-8.	Pamidronate	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
21413027-3	2011	Here, we investigated the role of phosphatidylcholine-specific phospholipase C (PC-PLC) in LPS-induced IL-8 and MCP-1 production in VECs.	Phosphatidylcholines	34-53	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
21413027-5	2011	Blocking the function of PC-PLC by exploiting the neutralization antibody of PC-PLC or tricyclodecan-9-yl-xanthogenate (D609), an inhibitor of PC-PLC, significantly inhibited LPS-induced production of IL-8 and MCP-1 in HUVECs.	tricyclodecan-9-yl-xanthogenate	87-118	C-X-C motif chemokine ligand 8	Homo sapiens	201-205
21413027-5	2011	Blocking the function of PC-PLC by exploiting the neutralization antibody of PC-PLC or tricyclodecan-9-yl-xanthogenate (D609), an inhibitor of PC-PLC, significantly inhibited LPS-induced production of IL-8 and MCP-1 in HUVECs.	tricyclodecane-9-yl-xanthogenate	120-124	C-X-C motif chemokine ligand 8	Homo sapiens	201-205
21384150-6	2011	dTBP2 inhibited the induction of IL-8 by dTCTP from BEAS-2B cells.	dtbp2	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
21401388-3	2011	CS activates epithelial cells to secrete chemokines such as interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) that recruit neutrophils and macrophages to the lung.	Cesium	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	60-73
21401388-3	2011	CS activates epithelial cells to secrete chemokines such as interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) that recruit neutrophils and macrophages to the lung.	Cesium	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
21401388-9	2011	Production of both chemokines was significantly reduced with SFN given prior to CSE; SFN inhibited IL-8 and MCP-1 gene expression at the transcription level.	sulforaphane	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
21770169-4	2011	In addition, we used a serum-containing medium to prevent the possible effects of IL-8 protein adsorption in the nano-ZnO and nano-TiO2.	Zinc Oxide	118-121	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
21384150-6	2011	dTBP2 inhibited the induction of IL-8 by dTCTP from BEAS-2B cells.	dtctp	41-46	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
21338358-8	2011	IL-8 up-regulation by LL-37 was completely abrogated by 20 mum U0126, consistent with transient phosphorylation of p44/42 MAP kinases.	U 0126	63-68	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
21770169-4	2011	In addition, we used a serum-containing medium to prevent the possible effects of IL-8 protein adsorption in the nano-ZnO and nano-TiO2.	titanium dioxide	131-135	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
21770169-7	2011	On the other hand, the IL-8 protein had a marked influence on the adsorption of nano-TiO2 in the serum-free medium.	titanium dioxide	85-89	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
21770169-8	2011	While only at 100 microg mL(-1) of nano-ZnO, an influence on the adsorption of IL-8 was observed.	Zinc Oxide	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
21338358-9	2011	Moreover, pretreatment with Brilliant Blue G (a selective antagonist of the P2X(7) receptor) and the neutralizing antibody against P2X(7) blocked IL-8 up-regulation in a dose-dependent manner, consistent with expression of the P2X(7) receptor in HGFs.	coomassie Brilliant Blue	28-44	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
21609799-7	2011	SP cotreatment restores DMVEC proliferation (211%) and tube formation (152%), and decreases IL-8 expression (34%) in DMVECs exposed to hyperglycemic conditions.	dmvecs	117-123	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
20174873-0	2011	Effects of 15-deoxy- 12,14-prostaglandin J2 on the production of IL-8 and the expression of Toll-like receptor 2 in human primary keratinocytes stimulated with lipopolysaccharide.	15-deoxy-delta(12,14)-prostaglandin J2	11-43	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
20174873-6	2011	15d-PGJ(2) decreased TLR2 mRNA, increased IL-8 production, and suppressed NF-kappaB activity.	15d-pgj	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
20174873-10	2011	Thus, 15d-PGJ(2) can have both anti- and pro-inflammatory effects, and 15d-PGJ(2)-mediated IL-8 up-regulation is related to the mitogen-activated protein kinase (MAPK) and NF-kappaB signaling pathways.	15d-pgj	71-78	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
21745629-0	2011	Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells.	Capsaicin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
21533553-4	2011	Exposure of HaCaT cells to CoCl(2) reduced cell viability and caused overproduction of reactive oxygen species (ROS) and oversecretion of interleukin-6 (IL-6) and interleukin-8 (IL-8).	cobaltous chloride	27-34	C-X-C motif chemokine ligand 8	Homo sapiens	163-176
21533553-4	2011	Exposure of HaCaT cells to CoCl(2) reduced cell viability and caused overproduction of reactive oxygen species (ROS) and oversecretion of interleukin-6 (IL-6) and interleukin-8 (IL-8).	cobaltous chloride	27-34	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
21533553-6	2011	Inhibition of COX-2 by NS-398, a selective inhibitor of COX-2, significantly repressed the cytotoxicity, as well as secretion of IL-6 and IL-8 induced by CoCl(2).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	23-29	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
21533553-6	2011	Inhibition of COX-2 by NS-398, a selective inhibitor of COX-2, significantly repressed the cytotoxicity, as well as secretion of IL-6 and IL-8 induced by CoCl(2).	cocl	154-158	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
21745629-9	2011	Our data suggest that the attenuation of palmitate-induced MIP-1 and IL-8 gene expressions by capsaicin is associated with reduced activation of c-Jun N-terminal kinase, c-Jun, and p38 and preserved beta-oxidation activity.	Palmitates	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
21745629-9	2011	Our data suggest that the attenuation of palmitate-induced MIP-1 and IL-8 gene expressions by capsaicin is associated with reduced activation of c-Jun N-terminal kinase, c-Jun, and p38 and preserved beta-oxidation activity.	Capsaicin	94-103	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
21533553-8	2011	Neutralizing anti-IL-6 or anti-IL-8 antibody statistically alleviated CoCl(2)-induced cytotoxicity in HaCaT cells.	cobaltous chloride	70-77	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
21745629-0	2011	Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells.	Palmitates	119-128	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
21745629-2	2011	In this study, we tested the hypothesis that the anti-inflammatory activity of capsaicin can be used to improve free fatty acid (FFA)-induced inflammation by reducing gene expression of macrophage inflammatory protein 1 (MIP-1) and interleukin 8 (IL-8) in THP-1 (human acute monocytic leukemia cell) macrophages.	Capsaicin	79-88	C-X-C motif chemokine ligand 8	Homo sapiens	232-245
21745629-2	2011	In this study, we tested the hypothesis that the anti-inflammatory activity of capsaicin can be used to improve free fatty acid (FFA)-induced inflammation by reducing gene expression of macrophage inflammatory protein 1 (MIP-1) and interleukin 8 (IL-8) in THP-1 (human acute monocytic leukemia cell) macrophages.	Capsaicin	79-88	C-X-C motif chemokine ligand 8	Homo sapiens	247-251
21745629-2	2011	In this study, we tested the hypothesis that the anti-inflammatory activity of capsaicin can be used to improve free fatty acid (FFA)-induced inflammation by reducing gene expression of macrophage inflammatory protein 1 (MIP-1) and interleukin 8 (IL-8) in THP-1 (human acute monocytic leukemia cell) macrophages.	Fatty Acids, Nonesterified	129-132	C-X-C motif chemokine ligand 8	Homo sapiens	232-245
21745629-2	2011	In this study, we tested the hypothesis that the anti-inflammatory activity of capsaicin can be used to improve free fatty acid (FFA)-induced inflammation by reducing gene expression of macrophage inflammatory protein 1 (MIP-1) and interleukin 8 (IL-8) in THP-1 (human acute monocytic leukemia cell) macrophages.	Fatty Acids, Nonesterified	129-132	C-X-C motif chemokine ligand 8	Homo sapiens	247-251
21745629-3	2011	To investigate whether capsaicin ameliorates palmitate-induced MIP-1 and IL-8 gene expressions, we treated THP-1 cells with palmitate in the presence or absence of capsaicin and measured MIP-1 and IL-8 by real-time polymerase chain reaction.	Capsaicin	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
21745629-3	2011	To investigate whether capsaicin ameliorates palmitate-induced MIP-1 and IL-8 gene expressions, we treated THP-1 cells with palmitate in the presence or absence of capsaicin and measured MIP-1 and IL-8 by real-time polymerase chain reaction.	Palmitates	45-54	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
21745629-0	2011	Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells.	Palmitates	21-30	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
21745629-4	2011	To elucidate the mechanism by which capsaicin effects on palmitate-induced MIP-1 and IL-8 gene expressions, we performed immunoblotting with stress kinase-related antibodies and measured palmitate oxidation and palmitate oxidation-related gene expression.	Capsaicin	36-45	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
21745629-4	2011	To elucidate the mechanism by which capsaicin effects on palmitate-induced MIP-1 and IL-8 gene expressions, we performed immunoblotting with stress kinase-related antibodies and measured palmitate oxidation and palmitate oxidation-related gene expression.	Palmitates	57-66	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
21745629-5	2011	Palmitate and stearate but not the unsaturated FFA oleate significantly increased MIP-1 and IL-8 expressions in THP-1 macrophages.	Palmitates	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
20817708-0	2011	Signalling pathway of isophorone diisocyanate-responsive interleukin-8 in airway smooth muscle cells.	isophorone diisocyanate	22-45	C-X-C motif chemokine ligand 8	Homo sapiens	57-70
21745629-5	2011	Palmitate and stearate but not the unsaturated FFA oleate significantly increased MIP-1 and IL-8 expressions in THP-1 macrophages.	Stearates	14-22	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
21745629-6	2011	Treatment with capsaicin or FFA oxidation stimulators inhibited palmitate-induced MIP-1 and IL-8 expressions in THP-1 macrophages.	Capsaicin	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
21745629-6	2011	Treatment with capsaicin or FFA oxidation stimulators inhibited palmitate-induced MIP-1 and IL-8 expressions in THP-1 macrophages.	Palmitates	64-73	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
21454676-3	2011	We previously demonstrated that the anti-inflammatory drugs dexamethasone and ibuprofen suppress NF-kappaB; however, only dexamethasone down-regulates cytokine-induced IL-8, highlighting the importance of non-NF-kappaB mechanisms.	Dexamethasone	122-135	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
21454676-6	2011	We observed that dexamethasone, but not ibuprofen, destabilizes IL-8 mRNA and up-regulates MKP-1 mRNA.	Dexamethasone	17-30	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
21454676-7	2011	Further, siRNA silencing of MKP-1, via p38 MAPK, leads to IL-8 overproduction and diminishes the anti-IL-8 potential of dexamethasone.	Dexamethasone	120-133	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
21454676-9	2011	By contrast, direct inhibition of p38 MAPK (inhibitor SB203580) efficiently suppresses IL-8 with potency comparable with dexamethasone.	SB 203580	54-62	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
21454676-10	2011	Similar to dexamethasone, SB203580 decreases IL-8 mRNA stability.	SB 203580	26-34	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
21703102-1	2011	The aim of this study was to assess the impact of a single nasal allergen challenge (NAC) on levels of eotaxin and IL-8 and the inflammatory cells in upper and lower airways of allergic rhinitis (AR) patients.	nac	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
21703102-7	2011	Post-NAC IL-8 levels were significantly increased in NLF (p &lt; 00001) but not in sputum (p = 0.080) of AR subjects.	nac	5-8	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
21299717-6	2011	Indeed, chromatin immunoprecipitation (ChIP) analysis showed that events related to transcriptional activation of the IL-8 gene region in response to TNF-alpha, including recruitment of RNA polymerase II (Pol II), were compromised in the presence of TSA.	trichostatin A	250-253	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
20817708-8	2011	Our study suggests that inhibition of IL-8 or IL-8-mediated FAK/ERK/Rnd3 signalling is an attractive therapeutic target for IPDI-mediated asthma.	isophorone diisocyanate	124-128	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
20817708-8	2011	Our study suggests that inhibition of IL-8 or IL-8-mediated FAK/ERK/Rnd3 signalling is an attractive therapeutic target for IPDI-mediated asthma.	isophorone diisocyanate	124-128	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
21536200-9	2011	Corrosion products, probably sodium aluminum fluoride (Na(3)AlF(6)), were observed on the implants after immersion in both NaF solutions for both time periods.	cryolite	29-53	C-X-C motif chemokine ligand 8	Homo sapiens	123-126
21536200-9	2011	Corrosion products, probably sodium aluminum fluoride (Na(3)AlF(6)), were observed on the implants after immersion in both NaF solutions for both time periods.	cryolite	55-67	C-X-C motif chemokine ligand 8	Homo sapiens	123-126
21615989-2	2011	Water-soluble extract of S. aureus cell lysate strongly induced human interleukin- 8 in human mast cell line-1 and mouse interleukin-6 in mouse bone marrow-derived mast cells.	Water	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	70-84
20817708-7	2011	FAK and ERK1/2 inhibitor also decreased IPDI-BEAS-2B-CM-, IPDI-HBEC-CM- and recombinant human IL-8-mediated BSMC proliferation and migration, whereas blocking Rnd3 using small interfering RNA failed to affect BSMC proliferation, suggesting that Rnd3 was only involved in the regulation of BSMC migration.	bsmc	108-112	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
20501519-6	2011	Using an antibody array approach, we found that ATO increased the production of several cytokines, with interleukin 8 (IL-8) being the predominant one.	Arsenic Trioxide	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	104-117
20501519-10	2011	Also, we conclude that the production of IL-8 is not induced by a caspase-4-dependent mechanism, suggesting that ATO-induced caspase-4 activation is involved in other as yet unidentified functions in human neutrophils.	Arsenic Trioxide	113-116	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
21761011-1	2011	The aim of this study was to examine the degree and prevalence of regional (aorta) and global (cardiac) fluorine-18-sodium fluoride ((18)F-NaF) uptake by positron emission tomography (PET)-computed tomography (CT) as evidence for calcification in the atherosclerotic plaques in the aorta and the heart as a function of age.	fluorine-18-sodium fluoride	104-131	C-X-C motif chemokine ligand 8	Homo sapiens	139-142
20501519-6	2011	Using an antibody array approach, we found that ATO increased the production of several cytokines, with interleukin 8 (IL-8) being the predominant one.	Arsenic Trioxide	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
20501519-7	2011	We confirmed that ATO increased the production of IL-8 by enzyme-linked-immunosorbent assay (ELISA).	Arsenic Trioxide	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
21605007-5	2011	Following ozone exposure, these purines remained correlated with IL-6, IL-8, and TNF-alpha (r = 0.37-0.68).	Purines	32-39	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
20648559-8	2011	Growth inhibition studies showed that IL-8 overexpression lead to a significant resistance to oxaliplatin (p &lt; 0.0001).	Oxaliplatin	94-105	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
20648559-9	2011	Inhibition of IL-8 overexpression with small interfering RNA reversed the observed increases in tumorigenic functions and oxaliplatin resistance, suggesting that IL-8 not only provides a proliferative advantage but also promotes the metastatic potential of colon cancer cells.	Oxaliplatin	122-133	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
20648559-9	2011	Inhibition of IL-8 overexpression with small interfering RNA reversed the observed increases in tumorigenic functions and oxaliplatin resistance, suggesting that IL-8 not only provides a proliferative advantage but also promotes the metastatic potential of colon cancer cells.	Oxaliplatin	122-133	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
21605007-4	2011	RESULTS: At baseline, the purines AMP and hypoxanthine correlated with multiple inflammatory markers including neutrophil counts and the cytokines interleukin (IL)-6, IL-8, tumor necrosis factor alpha (TNF-alpha), and IL-1beta (r ranged from 0.41 to 0.66, all P &lt; 0.05).	Purines	26-33	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
21531299-0	2011	Development and validation of an anion-exchange HPLC method for the determination of fluoride content and radiochemical purity in [18F]NaF.	Fluorides	85-93	C-X-C motif chemokine ligand 8	Homo sapiens	135-138
21605007-4	2011	RESULTS: At baseline, the purines AMP and hypoxanthine correlated with multiple inflammatory markers including neutrophil counts and the cytokines interleukin (IL)-6, IL-8, tumor necrosis factor alpha (TNF-alpha), and IL-1beta (r ranged from 0.41 to 0.66, all P &lt; 0.05).	Adenosine Monophosphate	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
21399866-8	2011	The long-term TMZ-treated astroglioma cells, but not the Hs683 oligodendroglioma cells, developed in vivo a certain level of resistance to TMZ, which correlated with the up- regulation of CXCL2, CXCL3 and CXCL8 expression in the U373 and T98G astroglioma cells.	Temozolomide	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	205-210
21300705-6	2011	Corticosteroid sensitivity was evaluated by the inhibition of tumor necrosis factor alpha (TNFalpha)-induced interleukin 8 (IL-8) production by budesonide.	Budesonide	144-154	C-X-C motif chemokine ligand 8	Homo sapiens	109-122
21300705-6	2011	Corticosteroid sensitivity was evaluated by the inhibition of tumor necrosis factor alpha (TNFalpha)-induced interleukin 8 (IL-8) production by budesonide.	Budesonide	144-154	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
21531299-1	2011	(18)F-labeled sodium fluoride ([(18)F]NaF) is a useful bone imaging agent that has been demonstrated to be significantly more accurate than (99m)Tc-labeled methylene diphosphonate for the detection of both sclerotic and lytic lesions in various malignancies.	Sodium Fluoride	14-29	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
21531299-3	2011	The method described for fluoride analysis uses an isocratic elution of NaF in a Hamilton anion-exchange column using a mobile phase that consists of 7.5 mM sodium carbonate and 0.018 mM potassium thiocyanate.	Fluorides	25-33	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
21531299-14	2011	Therefore, the method can be successfully performed for routine analysis of fluoride content in [(18)F]NaF radiopharmaceuticals and reduce the time required for analysis.	Fluorides	76-84	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
21488183-3	2011	Therefore, the aim of this study was to investigate the signal transduction pathway of nLDL-dependent IL-8 production and the effect of IL-8 on hAoSMCs migration.	haosmcs	144-151	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
21193553-7	2011	Addition of the p38 inhibitor SB203580 to Dianeal resulted in dampened IL-8 release (-55%; p &lt; 0.05) and basal HSP70 expression, and unchanged LDH release.	SB 203580	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
21193553-9	2011	CONCLUSION: These data confirm concordant p38-dependent upregulation of IL-8 and HSP70 following exposure to bioincompatible PDF.	pdf	125-128	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
21172926-8	2011	Treatment with SB202190 (p38-MAPK inhibitor) or PD98059 (ERK inhibitor) inhibited AGE-BSA-induced IL-6 and IL-8 expression.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
21172926-8	2011	Treatment with SB202190 (p38-MAPK inhibitor) or PD98059 (ERK inhibitor) inhibited AGE-BSA-induced IL-6 and IL-8 expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	48-55	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
21172926-9	2011	However, SP600125 (JNK inhibitor) had no effect on AGE-BSA-induced IL-6 expression but inhibited the expression of IL-8.	pyrazolanthrone	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
21826964-5	2011	However, BS and 18F-NaF PET/CT are more sensitive for sclerotic lesions, as a decreased 18F-FDG uptake in this subtype of lesion has been reported.	Fluorodeoxyglucose F18	88-95	C-X-C motif chemokine ligand 8	Homo sapiens	20-23
21297082-3	2011	Exposure of BEAS-2B and HBE to ANE, sANE, and arecoline increased interleukin 8 (IL-8) and Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES) production.	ane	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
21297082-3	2011	Exposure of BEAS-2B and HBE to ANE, sANE, and arecoline increased interleukin 8 (IL-8) and Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES) production.	ane	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
21297082-3	2011	Exposure of BEAS-2B and HBE to ANE, sANE, and arecoline increased interleukin 8 (IL-8) and Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES) production.	sane	36-40	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
21297082-3	2011	Exposure of BEAS-2B and HBE to ANE, sANE, and arecoline increased interleukin 8 (IL-8) and Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES) production.	sane	36-40	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
21297082-3	2011	Exposure of BEAS-2B and HBE to ANE, sANE, and arecoline increased interleukin 8 (IL-8) and Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES) production.	Arecoline	46-55	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
21297082-3	2011	Exposure of BEAS-2B and HBE to ANE, sANE, and arecoline increased interleukin 8 (IL-8) and Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES) production.	Arecoline	46-55	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
21488183-7	2011	IL-8-induced migration of hAoSMCs was evaluated by counting the cell numbers moved to lower chamber using Transwell plates.	haosmcs	26-33	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
21488183-8	2011	RESULTS: nLDL-induced IL-8 production was completely blocked by preincubation of hAoSMCs with pertussis toxin (PTX), which inhibited nLDL-dependent p38 MAPK phosphorylation.	haosmcs	81-88	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
21488183-10	2011	Pretreatment of PEG-Cat prevented nLDL-induced p38 MAPK phosphorylation and IL-8 production, which was partly mimicked by treatment with exogenous H2O22.	Polyethylene Glycols	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
21800536-6	2011	The results suggest that sodium nitrite could induce SMMC-7721 EMT by increased secretion of TGF-beta1 and IL-8.	Sodium Nitrite	25-39	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
21488183-10	2011	Pretreatment of PEG-Cat prevented nLDL-induced p38 MAPK phosphorylation and IL-8 production, which was partly mimicked by treatment with exogenous H2O22.	h2o22	147-152	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
21800536-6	2011	The results suggest that sodium nitrite could induce SMMC-7721 EMT by increased secretion of TGF-beta1 and IL-8.	smmc	53-57	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
21488183-12	2011	CONCLUSION: PTX-sensitive G-protein coupled receptor-dependent H2O2 generation by nLDL plays a critical role in IL-8 production in hAoSMC, and IL-8 may contribute to atherogenesis through increased migration of hAoSMCs.	Hydrogen Peroxide	63-67	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
21284934-8	2011	Hence, to survey the functionality of indomethacin after stimulation with contact allergens IL-8 and TRIM16 regulation was measured by a DC-based in vitro assay.	Indomethacin	38-50	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
21424022-4	2011	The produced DADB can be readily separated from the sodium fluoride (NaF) by-product by a purification procedure using liquid ammonia at -78  C. The thermal decomposition behavior of DADB was studied using synchronous thermal analyses, particularly in comparison with AB.	dadb	183-187	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
21329685-5	2011	Moreover the two highest concentrations of both fluoride-containing bioglasses and NaF caused increase of nitrite (a stable derivative of NO) levels in the culture supernatant, which was inhibited by l-NMMA, erythrocytes, PTIO and SOD/catalase, and increase of intracellular NO synthase (NOS) activity.	Nitrites	106-113	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
21329685-5	2011	Moreover the two highest concentrations of both fluoride-containing bioglasses and NaF caused increase of nitrite (a stable derivative of NO) levels in the culture supernatant, which was inhibited by l-NMMA, erythrocytes, PTIO and SOD/catalase, and increase of intracellular NO synthase (NOS) activity.	omega-N-Methylarginine	200-206	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
21329685-6	2011	The incubation with bioglasses or NaF increased also the phosphorylation of Ser(1177) in the endothelial NOS isoform.	Serine	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
21413719-0	2011	High temperature NMR study of aluminum metal influence on speciation in molten NaF-AlF3 fluorides.	Aluminum	30-44	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
21284934-9	2011	Incubation with isoeugenol after pre-treatment with indomethacin leads to increased IL-8 and TRIM16 gene expression.	isoeugenol	16-26	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
21496221-4	2011	In this article we have investigated the possible use of bergamot extracts (Citrus bergamia Risso) and their identified components to alter the expression of IL-8 associated with the cystic fibrosis airway pathology.	bergamot oil	57-65	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
21284934-9	2011	Incubation with isoeugenol after pre-treatment with indomethacin leads to increased IL-8 and TRIM16 gene expression.	Indomethacin	52-64	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
21496221-10	2011	CONCLUSIONS: These obtained results clearly indicate that bergapten and citropten are strong inhibitors of IL-8 expression and could be proposed for further studies to verify possible anti-inflammatory properties to reduce lung inflammation in CF patients.	5-Methoxypsoralen	58-67	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
21395877-6	2011	RESULTS: Budesonide and dexamethasone produced a concentration-dependent inhibition of the LPS-induced IL-8 and TNF-alpha secretion with an E(max) about 90% of inhibition, which was reduced by approximately 30% in the presence of H(2)O(2) or CSE.	Budesonide	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
21496221-10	2011	CONCLUSIONS: These obtained results clearly indicate that bergapten and citropten are strong inhibitors of IL-8 expression and could be proposed for further studies to verify possible anti-inflammatory properties to reduce lung inflammation in CF patients.	5,7-dimethoxycoumarin	72-81	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
21241417-8	2011	Importantly, catechins, in particular ECG, inhibited TNFalpha-induced activation of NF-kappaB and consequently secretion of pro-inflammatory and invasion promoting proteins like IL-8 and uPA.	Catechin	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
21241417-8	2011	Importantly, catechins, in particular ECG, inhibited TNFalpha-induced activation of NF-kappaB and consequently secretion of pro-inflammatory and invasion promoting proteins like IL-8 and uPA.	epicatechin gallate	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
21370925-4	2011	Exposure of BEAS-2B and HBE to DBP caused epithelial cells to produce inflammatory cytokines IL-8 and RANTES, which subsequently induced BSMC proliferation and migration.	bsmc	137-141	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
21370925-5	2011	Depleting both IL-8 and RANTES completely reversed the effect of DBP-BEAS-2B-CM and DBP-HBE-CM-mediated BSMC proliferation and migration, suggesting this effect is a synergistic influence of IL-8 and RANTES.	bsmc	104-108	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
21370925-5	2011	Depleting both IL-8 and RANTES completely reversed the effect of DBP-BEAS-2B-CM and DBP-HBE-CM-mediated BSMC proliferation and migration, suggesting this effect is a synergistic influence of IL-8 and RANTES.	bsmc	104-108	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
21468084-0	2011	Chitosan oligosaccharides suppress LPS-induced IL-8 expression in human umbilical vein endothelial cells through blockade of p38 and Akt protein kinases.	chitosan oligosaccharides	0-25	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
21468084-1	2011	AIM: To investigate whether and how COS inhibited IL-8 production in LPS-induced human umbilical vein endothelial cells (HUVECs).	carbonyl sulfide	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
21468084-4	2011	RESULTS: COS 50-200 mug/mL exerted a significant inhibitory effect on LPS 100 ng/mL-induced IL-8 expression in HUVECs at both the transcriptional and translational levels.	carbonyl sulfide	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
21468084-7	2011	Further, the over-expression of LPS-induced IL-8 mRNA in HUVECs was suppressed by a p38 MAPK inhibitor (SB203580, 25 mumol/L) or a phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002, 50 mumol/L).	SB 203580	104-112	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
21468084-7	2011	Further, the over-expression of LPS-induced IL-8 mRNA in HUVECs was suppressed by a p38 MAPK inhibitor (SB203580, 25 mumol/L) or a phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002, 50 mumol/L).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
21468084-8	2011	CONCLUSION: COS inhibited LPS-induced IL-8 expression in HUVECs through the blockade of the p38 MAPK and PI3K/Akt signaling pathways.	carbonyl sulfide	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
21442636-0	2011	Circulating levels of MCP-1, sIL-2R, IL-15, and IL-8 predict anemia response to pomalidomide therapy in myelofibrosis.	pomalidomide	80-92	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
21395877-6	2011	RESULTS: Budesonide and dexamethasone produced a concentration-dependent inhibition of the LPS-induced IL-8 and TNF-alpha secretion with an E(max) about 90% of inhibition, which was reduced by approximately 30% in the presence of H(2)O(2) or CSE.	Dexamethasone	24-37	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
21395877-6	2011	RESULTS: Budesonide and dexamethasone produced a concentration-dependent inhibition of the LPS-induced IL-8 and TNF-alpha secretion with an E(max) about 90% of inhibition, which was reduced by approximately 30% in the presence of H(2)O(2) or CSE.	Water	230-235	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
21316925-0	2011	An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway.	Benzo(a)pyrene	30-44	C-X-C motif chemokine ligand 8	Homo sapiens	80-93
21300765-0	2011	Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kappaB/IL-8 pathway that drives tumor angiogenesis.	Lactic Acid	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
21300765-4	2011	We found that lactate could enter endothelial cells through the monocarboxylate transporter MCT-1, trigger the phosphorylation/degradation of IkappaBalpha, and then stimulate an autocrine NF-kappaB/IL-8 (CXCL8) pathway driving cell migration and tube formation.	Lactic Acid	14-21	C-X-C motif chemokine ligand 8	Homo sapiens	198-202
21300765-4	2011	We found that lactate could enter endothelial cells through the monocarboxylate transporter MCT-1, trigger the phosphorylation/degradation of IkappaBalpha, and then stimulate an autocrine NF-kappaB/IL-8 (CXCL8) pathway driving cell migration and tube formation.	Lactic Acid	14-21	C-X-C motif chemokine ligand 8	Homo sapiens	204-209
21300765-7	2011	Finally, we documented in mouse xenograft models of human colorectal and breast cancer that lactate release from tumor cells through the MCT4 (and not MCT1) transporter is sufficient to stimulate IL-8-dependent angiogenesis and tumor growth.	Lactic Acid	92-99	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
21300765-8	2011	In conclusion, our findings establish a signaling role for lactate in endothelial cells and they identify the lactate/NF-kappaB/IL-8 pathway as an important link between tumor metabolism and angiogenesis.	Lactic Acid	110-117	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
21173096-5	2011	Neutrophils treated with simvastatin were submitted to interleukin 8-stimulated chemotaxis assays.	Simvastatin	25-36	C-X-C motif chemokine ligand 8	Homo sapiens	55-68
21173096-10	2011	Furthermore, intercellular adhesion molecule-1 expression was significantly abrogated on tumor necrosis factor-alpha-stimulated endothelium incubated with simvastatin, and statin treatment inhibited the interleukin-8-stimulated migration of both control and sickle cell disease neutrophils.	Simvastatin	155-166	C-X-C motif chemokine ligand 8	Homo sapiens	203-216
21267611-11	2011	Co-incubation of BEAS-2B cells with both gadolinium and iron resulted in diminished release of IL-8 relative to levels of the cytokine following incubation with gadolinium alone.	Gadolinium	41-51	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
21267611-11	2011	Co-incubation of BEAS-2B cells with both gadolinium and iron resulted in diminished release of IL-8 relative to levels of the cytokine following incubation with gadolinium alone.	Iron	56-60	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
21267611-11	2011	Co-incubation of BEAS-2B cells with both gadolinium and iron resulted in diminished release of IL-8 relative to levels of the cytokine following incubation with gadolinium alone.	Gadolinium	161-171	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
21316925-11	2011	Furthermore, the addition of N-acetyl cystein or catalase cancelled the IL-8 production by BaP, indicating that ROS production is essential for IL-8 production.	Reactive Oxygen Species	112-115	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
21368236-5	2011	The objective of the current study is to test the hypothesis that chemokines (eotaxin, RANTES, IL-8, and MIP-1alpha) can directly influence ASMC mass by increasing the rate of proliferation or enhancing the survival of these cells.	asmc	140-144	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
21368236-10	2011	In a concentration-dependent manner, chemokines including eotaxin, RANTES, IL-8, and MIP-1alpha increased ASMC"s [(3)H]thymidine incorporation and DNA synthesis.	asmc	106-110	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
21316925-11	2011	Furthermore, the addition of N-acetyl cystein or catalase cancelled the IL-8 production by BaP, indicating that ROS production is essential for IL-8 production.	Reactive Oxygen Species	112-115	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
21368236-10	2011	In a concentration-dependent manner, chemokines including eotaxin, RANTES, IL-8, and MIP-1alpha increased ASMC"s [(3)H]thymidine incorporation and DNA synthesis.	Thymidine	119-128	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
21368236-11	2011	IL-8, eotaxin, and MIP-1alpha decreased the rate of apoptosis of ASMCs compared with the matched controls.	asmcs	65-70	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
21316925-12	2011	RESULTS: This data highlights AhR-ROS-dependent regulation of IL-8 in NHEKs by BaP, providing a plausible explanation, at least in part, for why cigarette smoking exacerbates IL-8-related skin diseases such as psoriasis, palmoplantar pustulosis and acne.	Reactive Oxygen Species	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
21316925-12	2011	RESULTS: This data highlights AhR-ROS-dependent regulation of IL-8 in NHEKs by BaP, providing a plausible explanation, at least in part, for why cigarette smoking exacerbates IL-8-related skin diseases such as psoriasis, palmoplantar pustulosis and acne.	Reactive Oxygen Species	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
21193045-3	2011	Firstly, the immunomodulatory activity of the antibiotic was tested in vitro using Caco-2 intestinal epithelial cells and RAW 264.7 macrophages; minocycline was able to inhibit IL-8 and nitrite production, respectively.	Minocycline	145-156	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
21322034-2	2011	They present a conserved 3D structure, so-called IL8-like chemokine fold, which is supported by conserved cysteines forming intra-molecular disulfide bonds.	Cysteine	106-115	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
21042230-9	2011	Statistical analysis revealed that only IL-8 (rs4073, -251A&gt;T) showed significant differences in genotype and allele frequency between the control and APN or ALN cases.	apholate	154-157	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
21042230-9	2011	Statistical analysis revealed that only IL-8 (rs4073, -251A&gt;T) showed significant differences in genotype and allele frequency between the control and APN or ALN cases.	aln	161-164	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
21042230-10	2011	Following the elimination of vesicoureteral reflux, which is a significant risk factor for severe parenchymal infection, a single SNP in IL-8 (rs4073) was found to be associated with clinically severe ALN.	aln	201-204	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
21322034-2	2011	They present a conserved 3D structure, so-called IL8-like chemokine fold, which is supported by conserved cysteines forming intra-molecular disulfide bonds.	Disulfides	140-149	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
21316309-0	2011	Metformin modulates IL-8, IL-1beta, ICAM and IGFBP-1 expression in human endometrial stromal cells.	Metformin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
21322034-4	2011	However, it has been shown that different patterns can provide disulfide bonds fitting into an IL8-like architecture, which has been the key to identify new remote homologues of the IL8-like chemokine family.	Disulfides	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
21316309-7	2011	The negative effect of insulin on IL-8 (4.8 fold) and IL-1beta (9.3 fold) gene expression was similarly found in cells incubated with metformin.	Metformin	134-143	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
21322034-4	2011	However, it has been shown that different patterns can provide disulfide bonds fitting into an IL8-like architecture, which has been the key to identify new remote homologues of the IL8-like chemokine family.	Disulfides	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	182-185
21266580-3	2011	Thrombin-induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor (LY294002), an Akt inhibitor (1-L-6-hydroxymethyl-chiro-inositol-2-((R)-2-O-methyl-3-O-octadecylcarbonate)), and the dominant negative mutants of Rac1 (RacN17) and Akt (AktDN).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
21232592-8	2011	IL-8 secretion into the basolateral culture medium was increased at ZnO-NP concentrations of 5 mug/ml (P&lt;0.05), as shown by ELISA.	zno-np	68-74	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
21566865-6	2011	RESULTS: The mean values of fluoride concentration in the control group, NaF group and Duraphat varnish group were(0.0406+-0.0234)wt%,(0.1006+-0.1040)wt% and (0.1844+-0.1293)wt%,respectively.The concentration of fluoride in the Duraphat varnish group was significantly higher than that in the NaF group (P&lt;0.01).	Fluorides	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	73-76
21266580-3	2011	Thrombin-induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor (LY294002), an Akt inhibitor (1-L-6-hydroxymethyl-chiro-inositol-2-((R)-2-O-methyl-3-O-octadecylcarbonate)), and the dominant negative mutants of Rac1 (RacN17) and Akt (AktDN).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	22-27
21266580-3	2011	Thrombin-induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor (LY294002), an Akt inhibitor (1-L-6-hydroxymethyl-chiro-inositol-2-((R)-2-O-methyl-3-O-octadecylcarbonate)), and the dominant negative mutants of Rac1 (RacN17) and Akt (AktDN).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
21266580-3	2011	Thrombin-induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor (LY294002), an Akt inhibitor (1-L-6-hydroxymethyl-chiro-inositol-2-((R)-2-O-methyl-3-O-octadecylcarbonate)), and the dominant negative mutants of Rac1 (RacN17) and Akt (AktDN).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	45-50
21266580-3	2011	Thrombin-induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor (LY294002), an Akt inhibitor (1-L-6-hydroxymethyl-chiro-inositol-2-((R)-2-O-methyl-3-O-octadecylcarbonate)), and the dominant negative mutants of Rac1 (RacN17) and Akt (AktDN).	1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate	137-212	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
21266580-3	2011	Thrombin-induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor (LY294002), an Akt inhibitor (1-L-6-hydroxymethyl-chiro-inositol-2-((R)-2-O-methyl-3-O-octadecylcarbonate)), and the dominant negative mutants of Rac1 (RacN17) and Akt (AktDN).	1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate	137-212	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
21266580-3	2011	Thrombin-induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor (LY294002), an Akt inhibitor (1-L-6-hydroxymethyl-chiro-inositol-2-((R)-2-O-methyl-3-O-octadecylcarbonate)), and the dominant negative mutants of Rac1 (RacN17) and Akt (AktDN).	1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate	137-212	C-X-C motif chemokine ligand 8	Homo sapiens	45-50
21423807-10	2011	IL-8 production by carcinoma cells can be modulated by low doses of cyclophosphamide at the transcription level.	Cyclophosphamide	68-84	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
21399573-7	2011	This concentration of AC-PACs also significantly increased the secretion of IL-8 (6-fold) and inhibited the secretion of both MMP-2 and MMP-9.	ac-pacs	22-29	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
20463293-7	2011	The stimulation of IL-8 cytokine release was completely attenuated by treatment with the JNK-specific inhibitor, SP600125.	pyrazolanthrone	113-121	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
21193404-8	2011	Interestingly, alpha(1)-antitrypsin, in addition to its ability to neutralize NE and protease-3, can also bind heme and neutralize heme-induced IL-8 from CFBE41o(-) cells.	Heme	131-135	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
21248183-6	2011	RESULTS: Vitamin A-supplemented children with fecal MCP-1 or IL-8 concentrations less than the median of detectable concentrations and IL-10 concentrations of at least median concentrations had longer durations of EPEC infection than did children in the placebo group.	Vitamin A	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
21388551-10	2011	Oxysterols can induce the production of inflammatory cytokines such as interleukin-8 and interleukin-1beta.	Oxysterols	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
21193404-5	2011	One of the effects of this is the release of heme, and in this study we show that heme stimulates IL-8 and IL-10 protein production from DeltaF508 CFBE41o(-) bronchial epithelial cells.	Heme	82-86	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
21193404-6	2011	In addition, heme-induced IL-8 expression utilizes a novel pathway involving meprin, EGF receptor, and MyD88.	Heme	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
20870757-17	2011	Simvastatin decreased bronchoalveolar lavage IL-8 by 2.5-fold (P = 0.04).	Simvastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
21356375-0	2011	Novel roles for hypoxia and prostaglandin E2 in the regulation of IL-8 during endometrial repair.	Dinoprostone	28-44	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
21189358-6	2011	Dex suppressed genes in immune/inflammatory (IL-6, IL-8, and MCP-1, expressed in nonadipocytes) and proapoptotic pathways, yet induced genes related to the acute-phase response (SAA, factor D, haptoglobin, and RBP4, expressed in adipocytes) and stress/defense response.	Dexamethasone	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
21679503-12	2011	UFH or LMWH inhibited tumor necrosis factor alpha (10 ng/mL)-induced secretion of MUC5AC and IL-8 from NCI-H292 cells in a dose-dependent manner (0.01-10 IU/mL).	Heparin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
21356375-7	2011	IL-8 was increased by PGE(2) and hypoxia in secretory but not proliferative explants, which suggests that exposure to progesterone is essential.	Prostaglandins E	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
21679503-12	2011	UFH or LMWH inhibited tumor necrosis factor alpha (10 ng/mL)-induced secretion of MUC5AC and IL-8 from NCI-H292 cells in a dose-dependent manner (0.01-10 IU/mL).	Heparin, Low-Molecular-Weight	7-11	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
21679503-14	2011	CONCLUSION: These results indicate that heparin inhibits airway mucus hypersecretion in airway epithelial cells directly and indirectly through the suppression of IL-8 secretion and neutrophil infiltration.	Heparin	40-47	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
21356375-7	2011	IL-8 was increased by PGE(2) and hypoxia in secretory but not proliferative explants, which suggests that exposure to progesterone is essential.	Progesterone	118-130	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
21356375-9	2011	Epithelial cells treated simultaneously with PGE(2) and hypoxia demonstrated synergistic increases in IL-8.	Prostaglandins E	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
21356375-10	2011	Inhibition of HIF-1 by short hairpin RNA abolished hypoxic IL-8 induction, and inhibition of NF-kappaB by an adenoviral dominant negative inhibitor decreased PGE(2)-induced IL-8 expression (P &gt; 0.05).	Prostaglandins E	158-161	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
21356375-12	2011	Progesterone withdrawal, hypoxia, and PGE(2) regulate endometrial IL-8 by acting via HIF-1 and NF-kappaB.	Dinoprostone	38-44	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
21215400-10	2011	The AcLDL-induced IL-8 production was inhibited by LY294002 and filipin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
20848085-4	2011	The release of interleukin (IL)-8 and tumor necrosis factor (TNF) alpha from human monocytic THP-1 cells was significantly increased by treatment with MBZ, albendazole (ABZ), fenbendazole (FBZ), or oxibendazole (OBZ), but not by albendazole sulfoxide or praziquantel, suggesting that MBZ and structurally similar drugs can stimulate monocytes and increase the release of pro-inflammatory cytokines.	Mebendazole	151-154	C-X-C motif chemokine ligand 8	Homo sapiens	15-33
20848085-4	2011	The release of interleukin (IL)-8 and tumor necrosis factor (TNF) alpha from human monocytic THP-1 cells was significantly increased by treatment with MBZ, albendazole (ABZ), fenbendazole (FBZ), or oxibendazole (OBZ), but not by albendazole sulfoxide or praziquantel, suggesting that MBZ and structurally similar drugs can stimulate monocytes and increase the release of pro-inflammatory cytokines.	Albendazole	156-167	C-X-C motif chemokine ligand 8	Homo sapiens	15-33
20848085-4	2011	The release of interleukin (IL)-8 and tumor necrosis factor (TNF) alpha from human monocytic THP-1 cells was significantly increased by treatment with MBZ, albendazole (ABZ), fenbendazole (FBZ), or oxibendazole (OBZ), but not by albendazole sulfoxide or praziquantel, suggesting that MBZ and structurally similar drugs can stimulate monocytes and increase the release of pro-inflammatory cytokines.	Albendazole	169-172	C-X-C motif chemokine ligand 8	Homo sapiens	15-33
20848085-4	2011	The release of interleukin (IL)-8 and tumor necrosis factor (TNF) alpha from human monocytic THP-1 cells was significantly increased by treatment with MBZ, albendazole (ABZ), fenbendazole (FBZ), or oxibendazole (OBZ), but not by albendazole sulfoxide or praziquantel, suggesting that MBZ and structurally similar drugs can stimulate monocytes and increase the release of pro-inflammatory cytokines.	Fenbendazole	175-187	C-X-C motif chemokine ligand 8	Homo sapiens	15-33
20848085-4	2011	The release of interleukin (IL)-8 and tumor necrosis factor (TNF) alpha from human monocytic THP-1 cells was significantly increased by treatment with MBZ, albendazole (ABZ), fenbendazole (FBZ), or oxibendazole (OBZ), but not by albendazole sulfoxide or praziquantel, suggesting that MBZ and structurally similar drugs can stimulate monocytes and increase the release of pro-inflammatory cytokines.	Fenbendazole	189-192	C-X-C motif chemokine ligand 8	Homo sapiens	15-33
20848085-4	2011	The release of interleukin (IL)-8 and tumor necrosis factor (TNF) alpha from human monocytic THP-1 cells was significantly increased by treatment with MBZ, albendazole (ABZ), fenbendazole (FBZ), or oxibendazole (OBZ), but not by albendazole sulfoxide or praziquantel, suggesting that MBZ and structurally similar drugs can stimulate monocytes and increase the release of pro-inflammatory cytokines.	oxibendazole	198-210	C-X-C motif chemokine ligand 8	Homo sapiens	15-33
20848085-4	2011	The release of interleukin (IL)-8 and tumor necrosis factor (TNF) alpha from human monocytic THP-1 cells was significantly increased by treatment with MBZ, albendazole (ABZ), fenbendazole (FBZ), or oxibendazole (OBZ), but not by albendazole sulfoxide or praziquantel, suggesting that MBZ and structurally similar drugs can stimulate monocytes and increase the release of pro-inflammatory cytokines.	oxibendazole	212-215	C-X-C motif chemokine ligand 8	Homo sapiens	15-33
20848085-4	2011	The release of interleukin (IL)-8 and tumor necrosis factor (TNF) alpha from human monocytic THP-1 cells was significantly increased by treatment with MBZ, albendazole (ABZ), fenbendazole (FBZ), or oxibendazole (OBZ), but not by albendazole sulfoxide or praziquantel, suggesting that MBZ and structurally similar drugs can stimulate monocytes and increase the release of pro-inflammatory cytokines.	albendazole sulfoxide	229-250	C-X-C motif chemokine ligand 8	Homo sapiens	15-33
20848085-4	2011	The release of interleukin (IL)-8 and tumor necrosis factor (TNF) alpha from human monocytic THP-1 cells was significantly increased by treatment with MBZ, albendazole (ABZ), fenbendazole (FBZ), or oxibendazole (OBZ), but not by albendazole sulfoxide or praziquantel, suggesting that MBZ and structurally similar drugs can stimulate monocytes and increase the release of pro-inflammatory cytokines.	Praziquantel	254-266	C-X-C motif chemokine ligand 8	Homo sapiens	15-33
20848085-4	2011	The release of interleukin (IL)-8 and tumor necrosis factor (TNF) alpha from human monocytic THP-1 cells was significantly increased by treatment with MBZ, albendazole (ABZ), fenbendazole (FBZ), or oxibendazole (OBZ), but not by albendazole sulfoxide or praziquantel, suggesting that MBZ and structurally similar drugs can stimulate monocytes and increase the release of pro-inflammatory cytokines.	Mebendazole	284-287	C-X-C motif chemokine ligand 8	Homo sapiens	15-33
20848085-6	2011	Pretreatment with the MAP kinase/ERK kinase 1/2 inhibitor U0126 significantly suppressed the increase of IL-8 and TNFalpha levels by MBZ, ABZ, FBZ, or OBZ treatment in THP-1 cells, but the p38 mitogen-activated protein kinase inhibitor SB203580 or JNK1/2 inhibitor SP600125 did not.	U 0126	58-63	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
20848085-6	2011	Pretreatment with the MAP kinase/ERK kinase 1/2 inhibitor U0126 significantly suppressed the increase of IL-8 and TNFalpha levels by MBZ, ABZ, FBZ, or OBZ treatment in THP-1 cells, but the p38 mitogen-activated protein kinase inhibitor SB203580 or JNK1/2 inhibitor SP600125 did not.	Albendazole	138-141	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
20848085-7	2011	These results suggested that an ERK1/2 pathway plays an important role in the release of IL-8 and TNFalpha in THP-1 cells treated with MBZ and structurally similar drugs.	Mebendazole	135-138	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
21216561-5	2011	The results showed that atorvastatin significantly decreased the expression of six cytokines (IL-6, IL-8, IL-1, PAI-1, TGF-beta1, TGF-beta2) and five chemokines (CCL2, CCL7, CCL13, CCL18, CXCL1).	Atorvastatin	24-36	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
21121988-9	2011	Decrease in lesion progression was observed in Groups A, B and C. CONCLUSIONS: The 500 ppm NaF dentifrice demonstrated remineralization of carious lesions by virtue of a significant decrease in lesion depth; whereas dentifrices that contained AmF, MFP and MFP with xylitol decelerated the progression of demineralization.	Xylitol	265-272	C-X-C motif chemokine ligand 8	Homo sapiens	91-94
21073547-5	2011	In vitro studies in human lung epithelial cell lines showed that levofloxacin led to a dose-related reduction in IL-6 and IL-8 concentrations, with 300 mug mL(-1) resulting in the reduction of levels of IL-6 by fourfold and IL-8 by twofold (P&lt;0.05); in contrast, tobramycin increased IL-6 levels by 50%, but had no effect on IL-8.	Levofloxacin	65-77	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
21073547-5	2011	In vitro studies in human lung epithelial cell lines showed that levofloxacin led to a dose-related reduction in IL-6 and IL-8 concentrations, with 300 mug mL(-1) resulting in the reduction of levels of IL-6 by fourfold and IL-8 by twofold (P&lt;0.05); in contrast, tobramycin increased IL-6 levels by 50%, but had no effect on IL-8.	Levofloxacin	65-77	C-X-C motif chemokine ligand 8	Homo sapiens	224-228
21073547-5	2011	In vitro studies in human lung epithelial cell lines showed that levofloxacin led to a dose-related reduction in IL-6 and IL-8 concentrations, with 300 mug mL(-1) resulting in the reduction of levels of IL-6 by fourfold and IL-8 by twofold (P&lt;0.05); in contrast, tobramycin increased IL-6 levels by 50%, but had no effect on IL-8.	Levofloxacin	65-77	C-X-C motif chemokine ligand 8	Homo sapiens	224-228
20832139-10	2011	Interestingly, whereas Fas-mediated inhibition of phagocytosis and oxidative burst could be prevented by the broad range caspase inhibitor t-butoxycarbonyl-aspartyl(O-methyl)-fluoromethyl ketone (BocD-fmk), the chemotactic activity in response to IL-8 was unaffected.	ammonium ferrous sulfate	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	247-251
20832139-10	2011	Interestingly, whereas Fas-mediated inhibition of phagocytosis and oxidative burst could be prevented by the broad range caspase inhibitor t-butoxycarbonyl-aspartyl(O-methyl)-fluoromethyl ketone (BocD-fmk), the chemotactic activity in response to IL-8 was unaffected.	t-butoxycarbonyl-aspartyl(o-methyl)-fluoromethyl ketone	139-194	C-X-C motif chemokine ligand 8	Homo sapiens	247-251
20832139-10	2011	Interestingly, whereas Fas-mediated inhibition of phagocytosis and oxidative burst could be prevented by the broad range caspase inhibitor t-butoxycarbonyl-aspartyl(O-methyl)-fluoromethyl ketone (BocD-fmk), the chemotactic activity in response to IL-8 was unaffected.	bocd-fmk	196-204	C-X-C motif chemokine ligand 8	Homo sapiens	247-251
21254387-9	2011	CaCl(2) induced expression of IL-8 and TNFalpha in whole blood cultures.	Calcium Chloride	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
21147194-10	2011	The overall cumulative fluoride ion re-release according to the fluoride treatments was APF and NaF solution&gt;dentifrice.	Fluorides	23-31	C-X-C motif chemokine ligand 8	Homo sapiens	96-99
21176887-4	2011	RESULTS: CFTR F508 AECs secrete more CXCL8 in response to PsaDM than their wild type counterpart, which can be reversed by addition of extracellular glutathione or incubating AECs at 27 C to favour folding and expression of CFTR at the cell membrane.	Glutathione	149-160	C-X-C motif chemokine ligand 8	Homo sapiens	37-42
21282043-9	2011	Consequently, quercetin suppressed UV irradiation-induced expression of inflammatory cytokines IL-1beta (~60%), IL-6 (~80%), IL-8 (~76%) and TNF-alpha (~69%).	Quercetin	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
20940323-9	2011	Based on the analysis of the cytokine/chemokine content of sDC-SIGN culture supernatants, we identified IFN-gamma and CXCL8/IL-8 as inducers of sDC-SIGN production by MoDC.	S-[2-(Aminosulfonyl)ethyl]-D-Cysteine	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	118-123
20940323-9	2011	Based on the analysis of the cytokine/chemokine content of sDC-SIGN culture supernatants, we identified IFN-gamma and CXCL8/IL-8 as inducers of sDC-SIGN production by MoDC.	S-[2-(Aminosulfonyl)ethyl]-D-Cysteine	144-147	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
20940323-9	2011	Based on the analysis of the cytokine/chemokine content of sDC-SIGN culture supernatants, we identified IFN-gamma and CXCL8/IL-8 as inducers of sDC-SIGN production by MoDC.	S-[2-(Aminosulfonyl)ethyl]-D-Cysteine	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
20940323-9	2011	Based on the analysis of the cytokine/chemokine content of sDC-SIGN culture supernatants, we identified IFN-gamma and CXCL8/IL-8 as inducers of sDC-SIGN production by MoDC.	S-[2-(Aminosulfonyl)ethyl]-D-Cysteine	144-147	C-X-C motif chemokine ligand 8	Homo sapiens	118-123
21348878-4	2011	Accordingly, this review examines how varying degrees of CR-induced weight loss (i.e., &gt;10%, 5-10%, and &lt;5% from baseline) impact plasma levels and expression of adiponectin, leptin, resistin, interleukin 6 (IL-6), interleukin 8 (IL-8), monocyte chemotactic protein 1 (MCP-1), and retinol-binding protein 4 (RBP-4).	Chromium	57-59	C-X-C motif chemokine ligand 8	Homo sapiens	221-234
21485100-7	2011	ROS stimulates alveolar macrophages and neutrophils to release inflammatory cytokines, such as TNF-alpha, IL-8, IFN-gamma, IL-6 and IL-1beta.	Reactive Oxygen Species	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
20713976-8	2011	Exposure of HPMC to 3.4-DGE resulted in suppression of HSP, and increased release of LDH, IL-6 and IL-8.	hydroxypropylmethylcellulose-lactose matrix	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
20713976-8	2011	Exposure of HPMC to 3.4-DGE resulted in suppression of HSP, and increased release of LDH, IL-6 and IL-8.	3,4-dideoxyglucosone-3-ene	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
21348878-4	2011	Accordingly, this review examines how varying degrees of CR-induced weight loss (i.e., &gt;10%, 5-10%, and &lt;5% from baseline) impact plasma levels and expression of adiponectin, leptin, resistin, interleukin 6 (IL-6), interleukin 8 (IL-8), monocyte chemotactic protein 1 (MCP-1), and retinol-binding protein 4 (RBP-4).	Chromium	57-59	C-X-C motif chemokine ligand 8	Homo sapiens	236-240
21319354-7	2011	After cardiopulmonary bypass, IL-6, IL-8 and MDA levels were significantly increased, and the SOD level was significantly reduced in both two groups, but PF group exhibited lower IL-6, IL-8 and MDA levels and higher SOD levels than the MF group (p &lt; 0.05, respectively).	pyrazofurin	154-156	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
21299226-8	2011	Simulations of the CXCL-8 dimer complexed with a 24-mer heparin fragment and of the CXCL-8-receptor peptide complex revealed that Arg60, Lys64, and Arg68 in the dimer bind to cyclitols in a horseshoe pattern, defining a region which is spatially distinct from the receptor binding site.	Cyclitols	175-184	C-X-C motif chemokine ligand 8	Homo sapiens	19-25
21299226-9	2011	There appears to be an optimum number of sulfates and an optimum length of alkyl spacers required for the interaction of cyclitol inhibitors with the dimeric form of CXCL-8.	Sulfates	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	166-172
21299226-9	2011	There appears to be an optimum number of sulfates and an optimum length of alkyl spacers required for the interaction of cyclitol inhibitors with the dimeric form of CXCL-8.	Cyclitols	121-129	C-X-C motif chemokine ligand 8	Homo sapiens	166-172
21352551-6	2011	Peak respiratory burst activity was seen at 15-20 min, and superoxide levels returned to baseline by 1 h. IL-8 release was dependent on both membrane-associated CD14 (mCD14) and Toll-like receptor 4 (TLR4.	Superoxides	59-69	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
21352574-8	2011	In mucosa and polyp epithelial cells, mometasone inhibited this induced secretion while desloratadine inhibited IL-6 and IL-8.	desloratadine	88-101	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
21212273-6	2011	In addition, inhibition of IGF-1R activation by either its specific antagonist AG1024 or siRNA against IGF-1 significantly reduces NT-induced IL-8 expression and NF-kappaB-dependent reporter gene expression.	tyrphostin AG 1024	79-85	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
21275387-0	2011	Quercetin reduces neutrophil recruitment induced by CXCL8, LTB4, and fMLP: inhibition of actin polymerization.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	52-57
21352551-8	2011	Moreover, treatment with lovastatin inhibited LPS-dependent IL-8 release and superoxide production.	Lovastatin	25-35	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
21345194-0	2011	Effects of ulinastatin and docataxel on breast tumor growth and expression of IL-6, IL-8, and TNF-alpha.	docataxel	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
21091433-6	2011	A fluoride anion was found in the active site when NaF was added to the crystallization buffer.	fluoride anion	2-16	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
21345222-8	2011	OPN301 significantly decreased Pam3CSK4-induced cytokine production of tumour necrosis factor alpha (TNF-alpha), IL-1beta, IL-6, interferon (IFN)-gamma and IL-8 compared to IgG control in RA PBMCs and SFMCs cultures (all P &lt; 0.05).	opn301	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
21177635-8	2011	ERK1/2 pathway inhibitor, UO126, failed IL-8 promoter activity, whereas p38 MAPK inhibitor, SB203580, decreased the stabilization of IL-8 messenger RNA following V. parahaemolyticus infection.	SB 203580	92-100	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
21146504-3	2011	The PPARbeta/delta agonist GW501516 inhibited the increase caused by TNF-alpha in the mRNA levels of the NF-kappaB target genes interleukin 8 (IL-8), TNF-alpha and thymic stromal lymphopoietin (TSLP).	GW 501516	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	128-141
21146504-3	2011	The PPARbeta/delta agonist GW501516 inhibited the increase caused by TNF-alpha in the mRNA levels of the NF-kappaB target genes interleukin 8 (IL-8), TNF-alpha and thymic stromal lymphopoietin (TSLP).	GW 501516	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
21146504-11	2011	Finally, the reduction in IL-8 mRNA levels following GW501516 treatment in TNF-alpha-stimulated cells was abolished in the presence of the PPARbeta/delta antagonist GSK0660, the AMPK inhibitor compound C and the SIRT1 inhibitor sirtinol, indicating that the effects of GW501516 on NF-kappaB activity were dependent on PPARbeta/delta, AMPK and SIRT1, respectively.	GW 501516	53-61	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
21146504-11	2011	Finally, the reduction in IL-8 mRNA levels following GW501516 treatment in TNF-alpha-stimulated cells was abolished in the presence of the PPARbeta/delta antagonist GSK0660, the AMPK inhibitor compound C and the SIRT1 inhibitor sirtinol, indicating that the effects of GW501516 on NF-kappaB activity were dependent on PPARbeta/delta, AMPK and SIRT1, respectively.	GSK0660	165-172	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
21146504-11	2011	Finally, the reduction in IL-8 mRNA levels following GW501516 treatment in TNF-alpha-stimulated cells was abolished in the presence of the PPARbeta/delta antagonist GSK0660, the AMPK inhibitor compound C and the SIRT1 inhibitor sirtinol, indicating that the effects of GW501516 on NF-kappaB activity were dependent on PPARbeta/delta, AMPK and SIRT1, respectively.	sirtinol	228-236	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
21146504-11	2011	Finally, the reduction in IL-8 mRNA levels following GW501516 treatment in TNF-alpha-stimulated cells was abolished in the presence of the PPARbeta/delta antagonist GSK0660, the AMPK inhibitor compound C and the SIRT1 inhibitor sirtinol, indicating that the effects of GW501516 on NF-kappaB activity were dependent on PPARbeta/delta, AMPK and SIRT1, respectively.	GW 501516	269-277	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
20843633-7	2011	Increasing carbon chain length of straight chain alcohols positively correlated with their ability to inhibit detection of tumor necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10), but not with the detection of interleukin 6 (IL-6), interleukin 8, (IL-8), and interleukin 12 (IL-12).	Carbon	11-17	C-X-C motif chemokine ligand 8	Homo sapiens	243-256
21177434-8	2011	Formation of neutrophil extracellular traps was significantly enhanced by 5-LOX inhibition but attenuated by HETE-PE, whereas 5-HETE-PE enhanced superoxide and interleukin-8 generation.	5-hete-pe	126-135	C-X-C motif chemokine ligand 8	Homo sapiens	160-173
21213342-8	2011	The method is applied to a data set from a prospective clinical trial investigating the effectiveness of silver diamine fluoride (SDF) and sodium fluoride (NaF) varnish in arresting active dentin caries in the Chinese preschool children.	Sodium Fluoride	139-154	C-X-C motif chemokine ligand 8	Homo sapiens	156-159
21347371-6	2011	SAGEs bound LL-37 and inhibited interleukin-8 production induced by LL-37 in cultured human keratinocytes.	sages	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	32-45
20843633-7	2011	Increasing carbon chain length of straight chain alcohols positively correlated with their ability to inhibit detection of tumor necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10), but not with the detection of interleukin 6 (IL-6), interleukin 8, (IL-8), and interleukin 12 (IL-12).	Carbon	11-17	C-X-C motif chemokine ligand 8	Homo sapiens	259-263
20843633-7	2011	Increasing carbon chain length of straight chain alcohols positively correlated with their ability to inhibit detection of tumor necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10), but not with the detection of interleukin 6 (IL-6), interleukin 8, (IL-8), and interleukin 12 (IL-12).	Alcohols	49-57	C-X-C motif chemokine ligand 8	Homo sapiens	243-256
20946124-11	2011	Dexamethasone (100 nM) partially inhibited release of both IL-6 and IL-8.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
20843633-7	2011	Increasing carbon chain length of straight chain alcohols positively correlated with their ability to inhibit detection of tumor necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10), but not with the detection of interleukin 6 (IL-6), interleukin 8, (IL-8), and interleukin 12 (IL-12).	Alcohols	49-57	C-X-C motif chemokine ligand 8	Homo sapiens	259-263
20946124-8	2011	In human chondrocytes, BK increased release (over 24 h) of IL-6 and IL-8, effects blocked by MEN16132 but not by the B1 receptor antagonist Lys-[Leu8][desArg9]BK.	(4-amino-5-(4-(4-(2,4-dichloro-3-(2,4-dimethyl-8-quinolyloxymethyl)phenylsulfonamido)tetrahydro-2H-4-pyranoylcarbonyl)piperazino)-5-oxopentyl)(trimethyl)ammonium	93-101	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
21156725-6	2011	PPACK, U0126, U-73122, 2-APB or GF-109203X suppressed the increases in production of IL-8, GROalpha and MCP-1 induced by thrombin (P &lt; 0.001, P &lt;0.001 and P &lt;0.001, respectively).	2-aminoethoxydiphenyl borate	23-28	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
20940111-8	2011	Cord blood cytokines (IL-1beta, IL-8, IFNgamma, TNFalpha) showed a U-shaped association with U-As at GW30.	u-as	93-97	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
21156725-6	2011	PPACK, U0126, U-73122, 2-APB or GF-109203X suppressed the increases in production of IL-8, GROalpha and MCP-1 induced by thrombin (P &lt; 0.001, P &lt;0.001 and P &lt;0.001, respectively).	U 0126	7-12	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
21156725-6	2011	PPACK, U0126, U-73122, 2-APB or GF-109203X suppressed the increases in production of IL-8, GROalpha and MCP-1 induced by thrombin (P &lt; 0.001, P &lt;0.001 and P &lt;0.001, respectively).	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	14-21	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
20680429-3	2011	In the present study, we report effects of sodium fluoride (NaF) on the differentiation of a human epithelial cell line, HaCaT.	Sodium Fluoride	43-58	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
21156725-6	2011	PPACK, U0126, U-73122, 2-APB or GF-109203X suppressed the increases in production of IL-8, GROalpha and MCP-1 induced by thrombin (P &lt; 0.001, P &lt;0.001 and P &lt;0.001, respectively).	glycylphenylalanine	32-34	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
20672290-11	2011	The effect of LiCl on IL-6/IL-8/IL-10 secretion in iDC is mediated through inhibition of GSK-3beta.	Lithium Chloride	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
21093446-5	2011	This yields wild-type 72aa IL-8 with a serine at its N-terminus.	Serine	39-45	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
20472612-5	2011	High concentrations of hemin (50 muM) triggered TLR4-mediated IL-8 production in the human HEK293/TLR4 cell line in the absence of the co-receptors CD14 and MD-2; the latter an essential co-receptor for TLR4 activation by endotoxin.	Hemin	23-28	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
20472612-7	2011	Coprohemin, in contrast to hemin, is unable to trigger TLR4-dependent activation of HEK/TLR4 cells, but instead causes dose-dependent inhibition of endotoxin-stimulated IL-8 production.	coprohemin	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
20472612-7	2011	Coprohemin, in contrast to hemin, is unable to trigger TLR4-dependent activation of HEK/TLR4 cells, but instead causes dose-dependent inhibition of endotoxin-stimulated IL-8 production.	Hemin	5-10	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
20629184-7	2011	Curcumin significantly inhibited PMN chemotaxis against MIP-2, KC, or against conditioned media from LPS-treated macrophages or CEC, a well as the IL-8-mediated chemotaxis of human neutrophils.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
21175870-0	2011	Modulation of Interleukin-8 and staphylococcal flora by Avene hydrotherapy in patients suffering from chronic inflammatory dermatoses.	avene	56-61	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
21175870-8	2011	Similarly, a significant decrease in PASI was associated with a significant reduction of IL-8, S. aureus colonization and enterotoxin N in patients with psoriasis.	pasi	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
21221738-10	2011	F uptake was determined by difference from the original NaF concentration.	Fluorine	0-1	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
21456255-1	2011	This work reports the corrosion behavior of nanotubular oxide layers on Ti-29Nb-xZr alloys with different compositions by anodization in 1 M H3PO4 + 0.8 wt% NaF.	Oxides	56-61	C-X-C motif chemokine ligand 8	Homo sapiens	157-160
20663020-8	2011	RESULTS: Pretreatment of PBMCs with alendronate promoted lipid A-induced production of IL-1beta and IL-6, but decreased lipid A-induced IL-8 and MCP-1 production.	Alendronate	36-47	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
20663020-8	2011	RESULTS: Pretreatment of PBMCs with alendronate promoted lipid A-induced production of IL-1beta and IL-6, but decreased lipid A-induced IL-8 and MCP-1 production.	Lipid A	120-127	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
20663020-9	2011	In human gingival fibroblasts, alendronate pretreatment increased lipid A-induced production of IL-6 and IL-8, and increased NF-kappaB activation in gingival fibroblasts but not PBMCs stimulated with lipid A.	Alendronate	31-42	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
20663020-9	2011	In human gingival fibroblasts, alendronate pretreatment increased lipid A-induced production of IL-6 and IL-8, and increased NF-kappaB activation in gingival fibroblasts but not PBMCs stimulated with lipid A.	Lipid A	66-73	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
20663020-11	2011	Finally, SIS3 inhibited alendronate-augmented IL-6 and IL-8 production by human gingival fibroblasts but up-regulated alendronate-decreased IL-8 production by PBMCs.	Alendronate	24-35	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
20663020-11	2011	Finally, SIS3 inhibited alendronate-augmented IL-6 and IL-8 production by human gingival fibroblasts but up-regulated alendronate-decreased IL-8 production by PBMCs.	Alendronate	118-129	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
21093446-7	2011	Interleukin-8 is purified via cation exchange chromatography and heparin affinity chromatography using a single inexpensive buffer system.	Heparin	65-72	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
21241520-6	2011	RESULTS: There was a positive correlation between RDR to mannitol and eosinophil numbers (r = 0.47, p = 0.03) and level of IL-8 (r = 0.46, p = 0.04) in hypertonic saline-induced sputum.	Sodium Chloride	163-169	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
20951221-10	2011	Capsazepine reduced dsRNA-induced IL-8 and it prevented dsRNA-induced loss of the NF-kappaB repressor protein IkBalpha.	capsazepine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
21036957-9	2011	There was also an increase in interleukin-8 release by diatrizoate-treated cells indicating the possibility of proinflammatory effects of RCM.	Diatrizoate	55-66	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
21175131-4	2011	Three triterpenic acids dose-dependently decreased production and expression of VEGF and IL-8, retained glutathione level, lowered ROS and NO levels, and declined cell invasion and migration in test cell lines (P &lt; 0.05).	triterpenic acids	6-23	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
20739465-10	2011	Hypertonicity-induced increases in IL-6 and IL-8 releases were suppressed by exposure to capsazepine, AG 1478, ERK inhibitor PD 98059, p38 inhibitor SB 203580, or NF-kappaB inhibitor PDTC.	capsazepine	89-100	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
20739465-10	2011	Hypertonicity-induced increases in IL-6 and IL-8 releases were suppressed by exposure to capsazepine, AG 1478, ERK inhibitor PD 98059, p38 inhibitor SB 203580, or NF-kappaB inhibitor PDTC.	RTKI cpd	102-109	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
20739465-10	2011	Hypertonicity-induced increases in IL-6 and IL-8 releases were suppressed by exposure to capsazepine, AG 1478, ERK inhibitor PD 98059, p38 inhibitor SB 203580, or NF-kappaB inhibitor PDTC.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	125-133	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
20739465-10	2011	Hypertonicity-induced increases in IL-6 and IL-8 releases were suppressed by exposure to capsazepine, AG 1478, ERK inhibitor PD 98059, p38 inhibitor SB 203580, or NF-kappaB inhibitor PDTC.	SB 203580	149-158	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
24212612-7	2011	IL-8 production was stimulated by Lys8-psi-Lys9NT (8-13) and even enhanced at both acidic and alkaline pHe in BxPC-3 and PANC-1 cells.	lys8-psi-lys9nt	34-49	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
20920494-5	2011	LPS-induced ICAM-1 and IL-8 expression was associated with increased superoxide formation in AEC.	Superoxides	69-79	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
21062641-12	2011	In the presence of p38-MAPK and Syk inhibitors and monosodium urate crystals, IL-8 release was reduced.	Uric Acid	51-67	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
21087659-5	2011	Also, exposure to HCHO for 30 min dose-dependently inhibited basal and lipopolysaccharide-induced interleukin-6 (IL-6) and IL-8 production by bronchial epithelial cells.	Formaldehyde	18-22	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
24212612-7	2011	IL-8 production was stimulated by Lys8-psi-Lys9NT (8-13) and even enhanced at both acidic and alkaline pHe in BxPC-3 and PANC-1 cells.	Phenylalanine	103-106	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
22110498-8	2011	Alveolar and plasma concentrations of IL-8 and TNF-alpha were significantly lower in the isoflurane group, whereas alveolar and plasma concentrations of MDA were significantly lower in the propofol group.	Isoflurane	89-99	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
21809637-1	2011	People exposed to chronic influence of hydrogen sulphide gas demonstrate accelerated aging, increase of proinflammatory cytokine interleukin-8 level and the marker of apoptosis protein p53.	Hydrogen Sulfide	39-56	C-X-C motif chemokine ligand 8	Homo sapiens	129-142
21711965-10	2011	Bay-117082 abolished hypoxia-stimulated IL-8 and VEGF synthesis, whereas Cyr61 restored the stimulative effect of hypoxia readily.	3-(4-methylphenylsulfonyl)-2-propenenitrile	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
21459369-6	2011	This response correlated with IL-8 but not TNFalpha or IL-6 production, and was abrogated by the NFkappaB inhibitor BAY 11-7082.	3-(4-methylphenylsulfonyl)-2-propenenitrile	116-127	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
21468920-0	2011	Polyozellin blocks tumor necrosis factor alpha-induced interleukin 8 and matrix metalloproteinase 7 production in the human intestinal epithelial cell line HT-29.	polyozellin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	55-68
21468920-3	2011	Polyozellin significantly inhibited tumor necrosis factor (TNF)-alpha-induced interleukin-8 secretion and mRNA expression.	polyozellin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	78-91
20844277-10	2011	The SIRT1 activators resveratrol and SRT1720 significantly decreased LPS-induced TNF, IL6, and IL8 gene expression and release and PTGS2 mRNA expression and resultant prostaglandin (PG) E(2) and PGF(2alpha) release from human gestational tissues.	Resveratrol	21-32	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
20952496-7	2011	TTP binds to AU-rich elements in the 3"-UTR of the IL-8 mRNA.	Gold	13-15	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
22040886-3	2011	We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha-induced production and mRNA expression of IL-8, IL-6 and IL-1beta from RA patient-derived fibroblast-like synovial cell line MH7A.	Dihydrotestosterone	33-59	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
22040886-3	2011	We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha-induced production and mRNA expression of IL-8, IL-6 and IL-1beta from RA patient-derived fibroblast-like synovial cell line MH7A.	Dihydrotestosterone	61-64	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
22040886-4	2011	Promoter analysis of the IL-8 gene revealed that nuclear factor (NF)-kappaB activation is critical for its transcriptional activation by IL-1alpha, and DHT inhibited the IL-1alpha-induced NF-kappaB activation in a manner dependent on the androgen receptor (AR).	Dihydrotestosterone	152-155	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
21787693-4	2011	Nivalenol elicited interleukin (IL)-8 secretion.	nivalenol	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	19-37
21752354-3	2011	Stimulation of Fas induced the expression of pro-inflammatory mediators such as matrix metalloproteinase (MMP)-9 and IL-8.	ammonium ferrous sulfate	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
21943646-5	2011	Here, we show that the effect of plasma membrane cholesterol depletion on the inhibition of Akt activation allows sustained ERK activation and the subsequent upregulation of IL-8 expression.	Cholesterol	49-60	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
21787693-5	2011	IL-8 secretion was lower in cells concomitantly treated with nivalenol and NF-kappaB inhibitors than with nivalenol alone.	nivalenol	61-70	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
21787693-5	2011	IL-8 secretion was lower in cells concomitantly treated with nivalenol and NF-kappaB inhibitors than with nivalenol alone.	nivalenol	106-115	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
20950664-6	2011	CbpA could also induce the release of inflammatory cytokine interleukin-6, and chemokines CCL2, CXCL1, and CXCL8 from human bronchial epithelia cells.	cbpa	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	107-112
21227887-7	2011	Tacrolimus was also demonstrated to down-regulate IFN-gamma-induced the secretion of chemotactic factor CXCL-8 and the expression of intercellular adhesion molecule-1 and human leucocyte antigen HLA-DR.	Tacrolimus	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	104-110
20950664-8	2011	CbpA was also found to participate in the induction of IL-6, CCL2, CXCL1, and CXCL8 in the airways of mice upon intranasal challenge with S. pneumoniae.	cbpa	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	78-83
20809700-0	2011	Evaluation of interleukin-8 in hepatitis C virus infection: relation to combined peg-interferon ribavirin response and genotype 4.	Ribavirin	96-105	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
20809700-3	2011	The aim of the present study was to investigate the relationship among levels of IL-8 in serum of subjects with past exposure to HCV indicated by positive IgG to HCV and negative PCR, patients with chronic HCV infections and in responder to combined alfa IFN and ribavirin therapy.	Ribavirin	263-272	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
21646801-10	2011	Budesonide significantly inhibited R-837-induced IL-8 production in a concentration-dependent manner, and procaterol potentiated inhibition by budesonide although single-agent procaterol had no effect.	Budesonide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
20809700-8	2011	The present study highlights the kinetic of serum levels of interleukin-8 in patients with chronic hepatitis C genotype 4 before and after therapy with combined alfa interferon and ribavirin.	Ribavirin	181-190	C-X-C motif chemokine ligand 8	Homo sapiens	60-73
20722064-5	2011	ATP increased flagellin-induced IL-8 secretion but reduced CCL20 secretion via distinct signaling pathways.	Adenosine Triphosphate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
20722064-6	2011	RESULTS: ATP-enhanced IL-8 production was only partly blocked by the P(2) receptor antagonist suramin and required activation of NF-kappaB while ATP-mediated reduction of CCL20 was completely blocked by suramin and required activation of ERK1/2.	Adenosine Triphosphate	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
20722064-6	2011	RESULTS: ATP-enhanced IL-8 production was only partly blocked by the P(2) receptor antagonist suramin and required activation of NF-kappaB while ATP-mediated reduction of CCL20 was completely blocked by suramin and required activation of ERK1/2.	Suramin	94-101	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
21646801-10	2011	Budesonide significantly inhibited R-837-induced IL-8 production in a concentration-dependent manner, and procaterol potentiated inhibition by budesonide although single-agent procaterol had no effect.	Imiquimod	35-40	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
22003289-0	2011	Suppression of IL-8 production from airway cells by tiotropium bromide in vitro.	Tiotropium Bromide	52-70	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
22003289-3	2011	PURPOSE: The present study aimed to examine the influence of tiotropium bromide on the production of interleukin (IL)-8 from human airway epithelial cells and lung fibroblasts (LFs) after lipopolysaccharide (LPS) stimulation in vitro.	Tiotropium Bromide	61-79	C-X-C motif chemokine ligand 8	Homo sapiens	101-119
22003289-8	2011	RESULTS: Tiotropium bromide at &gt; 15 pg/mL inhibited IL-8 production from both BEAS-2B cells and LFs after LPS stimulation.	Tiotropium Bromide	9-27	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
22003289-9	2011	Tiotropium bromide also suppressed IL-8 mRNA expression through the inhibition of NF-kappaB activation and signaling protein, extracellular-signal-regulated kinase 1/2, and c-Jun N-terminal kinase, phosphorylation.	Tiotropium Bromide	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
21496413-5	2011	In animal models and in vitro models, after treatment with Bosentan, a significant reduction of cytokine (TNF alpha, IFN gamma,IL-8, IL-4) levels was observed.	Bosentan	59-67	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
22003289-10	2011	CONCLUSION: The present results strongly suggest that tiotropium bromide exerts the inhibitory effect on neutrophilic inflammation through the suppression of IL-8 production from epithelial cells and LFs by interfering with LPS-mediated signaling pathways and thus may contribute to lower cellular inflammation in COPD, which is responsible for favorable modification of the disease.	Tiotropium Bromide	54-72	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
21496413-11	2011	Bosentan significantly reduced IL-2, IL-6, IL-8 and IFN- gamma levels in SSc patients, probably slowing progression to fibrosis and vascular damage.	Bosentan	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
21224438-5	2011	The release of proinflammatory cytokines (tumor necrosis factor alpha, interleukin-6, and interleukin-8) was reduced by 1:1 and 1:2 DHA/AA ratios (P &lt; .01 to P &lt; .001) but increased by 1:4 and 1:7 DHA/AA ratios (P &lt; .01 to P &lt; .001) vs control.	Docosahexaenoic Acids	132-135	C-X-C motif chemokine ligand 8	Homo sapiens	90-103
22403987-11	2011	The positive control toothpaste containing 8.0% arginine and 1450 ppm fluoride as MFP in a calcium carbonate base provided statistically significant improvements in mean tactile and air blast dentin hypersensitivity scores compared to the negative control toothpaste containing 1100 ppm fluoride as NaF in a silica base (p &lt; 0.05).	Fluorides	70-78	C-X-C motif chemokine ligand 8	Homo sapiens	299-302
22403987-12	2011	The toothpaste containing 8.0% arginine and 1450 ppm fluoride as MFP in a calcium carbonate base (positive control) also provided statistically significant improvements in mean tactile and air blast dentin hypersensitivity scores compared to the test toothpaste containing 8% strontium acetate and 1040 ppm fluoride as NaF in a silica base.	Fluorides	53-61	C-X-C motif chemokine ligand 8	Homo sapiens	319-322
22403987-14	2011	CONCLUSION: The test toothpaste containing 8% strontium acetate and 1040 ppm fluoride as NaF in a silica base, when used for a single topical application and twice-daily brushing for seven days, does not provide statistically significant relief of dentin hypersensitivity compared to a negative control toothpaste containing 1100 ppm fluoride as NaF in a silica base.	Fluorides	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	89-92
22403987-14	2011	CONCLUSION: The test toothpaste containing 8% strontium acetate and 1040 ppm fluoride as NaF in a silica base, when used for a single topical application and twice-daily brushing for seven days, does not provide statistically significant relief of dentin hypersensitivity compared to a negative control toothpaste containing 1100 ppm fluoride as NaF in a silica base.	Silicon Dioxide	98-104	C-X-C motif chemokine ligand 8	Homo sapiens	89-92
22403987-14	2011	CONCLUSION: The test toothpaste containing 8% strontium acetate and 1040 ppm fluoride as NaF in a silica base, when used for a single topical application and twice-daily brushing for seven days, does not provide statistically significant relief of dentin hypersensitivity compared to a negative control toothpaste containing 1100 ppm fluoride as NaF in a silica base.	silica base	98-109	C-X-C motif chemokine ligand 8	Homo sapiens	89-92
20882041-4	2011	In particular, IL-8, urokinase-like plasminogen activator receptor, and metalloproteinases are highly upregulated after cholesterol extraction.	Cholesterol	120-131	C-X-C motif chemokine ligand 8	Homo sapiens	15-66
21099203-6	2011	M-TriDAP induced a dose-dependent release of IL-8, MIP-1alpha, MIP-1beta and TNF.	L-Ala-gamma-D-Glu-meso-diaminopimelic acid	2-8	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
20382011-4	2011	We found that GPE attenuated TNFalpha-induced expression of inflammatory genes including interleukin (IL)-6, IL-1beta, IL-8, monocyte chemoattractant protein (MCP)-1, cyclooxygenase (COX)-2 and Toll-like receptor (TLR)-2.	gpe	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
20594065-2	2011	Fluoridated HA (fluorapatite) was prepared by reacting resorbable synthetic HA (OsteoGen, Impladent, Ltd, Holliswood, NY) with 4.3% sodium fluoride (NaF) for 2 minutes.	fluorapatite	16-28	C-X-C motif chemokine ligand 8	Homo sapiens	149-152
21992563-6	2011	However, an in vivo neutrophil migration assay following 5d-FRH and during the post-exposure recovery period also showed persistently enhanced neutrophil influx in response to a fixed chemotactic gradient generated by recombinant human IL-8, suggesting that additional mechanisms besides increased ELR + CXC chemokines contributed to the augmented neutrophil response caused by 5d-FRH exposure.	5d-frh	57-63	C-X-C motif chemokine ligand 8	Homo sapiens	236-240
21992563-6	2011	However, an in vivo neutrophil migration assay following 5d-FRH and during the post-exposure recovery period also showed persistently enhanced neutrophil influx in response to a fixed chemotactic gradient generated by recombinant human IL-8, suggesting that additional mechanisms besides increased ELR + CXC chemokines contributed to the augmented neutrophil response caused by 5d-FRH exposure.	5d-frh	378-384	C-X-C motif chemokine ligand 8	Homo sapiens	236-240
22121382-8	2011	Salmeterol increased, while dexamethasone and fluticasone decreased RV-induced IL-6 and IL-8 (P&lt;0.05).	Dexamethasone	28-41	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
22121382-8	2011	Salmeterol increased, while dexamethasone and fluticasone decreased RV-induced IL-6 and IL-8 (P&lt;0.05).	Fluticasone	46-57	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
22403977-14	2011	CONCLUSION: The results of this double-blind clinical study support that 1) an alcohol-free mouthwash containing a combination of 0.075% CPC and 0.05% NaF produces statistically significant reductions in dental plaque and gingivitis after three and six months compared to baseline, and 2) the alcohol-free CPC mouthwash provides a statistically significantly greater level of efficacy in controlling established dental plaque and gingivitis after three and six months of product use as compared to the Control Mouthwash containing only NaF.	Alcohols	79-86	C-X-C motif chemokine ligand 8	Homo sapiens	151-154
22403977-14	2011	CONCLUSION: The results of this double-blind clinical study support that 1) an alcohol-free mouthwash containing a combination of 0.075% CPC and 0.05% NaF produces statistically significant reductions in dental plaque and gingivitis after three and six months compared to baseline, and 2) the alcohol-free CPC mouthwash provides a statistically significantly greater level of efficacy in controlling established dental plaque and gingivitis after three and six months of product use as compared to the Control Mouthwash containing only NaF.	Alcohols	79-86	C-X-C motif chemokine ligand 8	Homo sapiens	536-539
22403977-14	2011	CONCLUSION: The results of this double-blind clinical study support that 1) an alcohol-free mouthwash containing a combination of 0.075% CPC and 0.05% NaF produces statistically significant reductions in dental plaque and gingivitis after three and six months compared to baseline, and 2) the alcohol-free CPC mouthwash provides a statistically significantly greater level of efficacy in controlling established dental plaque and gingivitis after three and six months of product use as compared to the Control Mouthwash containing only NaF.	Cetylpyridinium	137-140	C-X-C motif chemokine ligand 8	Homo sapiens	536-539
22403977-14	2011	CONCLUSION: The results of this double-blind clinical study support that 1) an alcohol-free mouthwash containing a combination of 0.075% CPC and 0.05% NaF produces statistically significant reductions in dental plaque and gingivitis after three and six months compared to baseline, and 2) the alcohol-free CPC mouthwash provides a statistically significantly greater level of efficacy in controlling established dental plaque and gingivitis after three and six months of product use as compared to the Control Mouthwash containing only NaF.	Alcohols	293-300	C-X-C motif chemokine ligand 8	Homo sapiens	151-154
22403977-14	2011	CONCLUSION: The results of this double-blind clinical study support that 1) an alcohol-free mouthwash containing a combination of 0.075% CPC and 0.05% NaF produces statistically significant reductions in dental plaque and gingivitis after three and six months compared to baseline, and 2) the alcohol-free CPC mouthwash provides a statistically significantly greater level of efficacy in controlling established dental plaque and gingivitis after three and six months of product use as compared to the Control Mouthwash containing only NaF.	Cetylpyridinium	306-309	C-X-C motif chemokine ligand 8	Homo sapiens	151-154
20454998-6	2011	Conversely, enforced expression of CypA in the CypA KD cell line, Ud-12, markedly enhanced IL-8 transcripts and restored Ud-12 proliferation, suggesting that CypA-mediated IL-8 production provides a growth advantage to glioblastoma cells.	UD	66-68	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
20454998-6	2011	Conversely, enforced expression of CypA in the CypA KD cell line, Ud-12, markedly enhanced IL-8 transcripts and restored Ud-12 proliferation, suggesting that CypA-mediated IL-8 production provides a growth advantage to glioblastoma cells.	UD	66-68	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
21908944-0	2011	beta-Carotene and lutein inhibit hydrogen peroxide-induced activation of NF-kappaB and IL-8 expression in gastric epithelial AGS cells.	beta Carotene	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
21908944-0	2011	beta-Carotene and lutein inhibit hydrogen peroxide-induced activation of NF-kappaB and IL-8 expression in gastric epithelial AGS cells.	Hydrogen Peroxide	33-50	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
21908944-7	2011	The present study aims to investigate whether beta-carotene and lutein inhibit H(2)O(2)-induced activation of NF-kappaB and expression of IL-8 in gastric epithelial AGS cells.	beta Carotene	46-59	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
21908944-7	2011	The present study aims to investigate whether beta-carotene and lutein inhibit H(2)O(2)-induced activation of NF-kappaB and expression of IL-8 in gastric epithelial AGS cells.	Hydrogen Peroxide	79-87	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
21908944-13	2011	As a result, H(2)O(2 )induced the activation of NF-kappaB and expression of IL-8 in AGS cells time-dependently.	Hydrogen Peroxide	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
21908944-14	2011	beta-Carotene and lutein showed inhibitory effects on H(2)O(2)-induced increase in intracellular ROS levels, activation of NF-kappaB, and IL-8 expression in AGS cells.	beta Carotene	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
21908944-14	2011	beta-Carotene and lutein showed inhibitory effects on H(2)O(2)-induced increase in intracellular ROS levels, activation of NF-kappaB, and IL-8 expression in AGS cells.	Hydrogen Peroxide	54-62	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
22470793-0	2011	Particle disease on fluoride-18 (NaF) PET/CT imaging.	fluoride-18	20-31	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
22531121-7	2011	The concentrations of IL-6, IL-8, VEGF and MMP-2 protein in the culture supernatant of MKN-45P were significantly higher than those of MKN-45.	mkn-45p	87-94	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
22531121-7	2011	The concentrations of IL-6, IL-8, VEGF and MMP-2 protein in the culture supernatant of MKN-45P were significantly higher than those of MKN-45.	mkn-45	87-93	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
21954641-1	2011	The use of metformin during the first month of treatment of patients with coronary artery disease and diabetes type 2 led to the decrease of insulin resistance and reduced activity of systemic inflammation (significant decrease in the concentrations of IL-1, IL-6, IL-8 and TNF-alpha).	Metformin	11-20	C-X-C motif chemokine ligand 8	Homo sapiens	265-269
21938919-1	2011	The authors revealed increase in ageing pace, higher level of pro-inflammatory cytokine Interleukin-8 and apoptosis marker (p53 protein) in individuals with chronic exposure to gas containing hydrogen sulfide.	Hydrogen Sulfide	192-208	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
21765616-0	2011	Modulation of NK cell autocrine-induced eosinophil chemotaxis by interleukin-15 and vitamin D(3): a possible NK-eosinophil crosstalk via IL-8 in the pathophysiology of allergic rhinitis.	Vitamin D	84-93	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
21765616-5	2011	The amount of IL-8 secreted by NK cells was increased by IL-15 treatment from levels of 88.64 +- 21.5 to 178.9 +- 23.6 Pg/mL and was significantly reduced by 10(-6) M vitamin D(3) to levels of 59.2 +- 16.3 Pg/mL.	Vitamin D	167-176	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
21112343-9	2011	Using inhibitor SN50, palmitate-induced expression of IL8, CXCL3 and CCL20 was NFkappaB-dependent (all p&lt;0.05).	Palmitates	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
21765616-6	2011	Our results indicate a novel inflammatory crosstalk between NK cells and eosinophils via IL-15/IL-8 axis that can be modulated by vitamin D(3).	Vitamin D	130-139	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
21057930-2	2011	The output of an ELISpot assay is a formation of colored spots which appear at the sites of cells releasing cytokines, with each individual spot representing a single cytokine-releasing cell.We have shown that hydrogen peroxide-induced oxidative stress was causing ~twofold decrease in the number of lymphocytes secreting the TH1 cytokines IFN-gamma and IL-2, as well as chemokine IL-8 and cytokine TNF alpha.	Hydrogen Peroxide	210-227	C-X-C motif chemokine ligand 8	Homo sapiens	381-385
21057930-5	2011	We adopted ELISpot assay for studying oxidative stress in human peripheral blood lymphocytes by analyzing the acute effect of hydrogen peroxide treatment on the frequency of cells secreting IFN-gamma, IL-2, IL-4, IL-5, IL-8, and TNF-alpha.	Hydrogen Peroxide	126-143	C-X-C motif chemokine ligand 8	Homo sapiens	219-223
21112343-10	2011	Furthermore, JNK was involved in palmitate-induced expression of IL1A, IL8, CXCL3, SPP1 and CEBPB as determined with inhibitor SP600125 (all p&lt;0.05).	Palmitates	33-42	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
21269946-7	2011	ADMA treatment also resulted in a dose-dependent increase of the levels of TNF-alpha and IL-8 in the culture supernatant of the macrophages, and the peak levels occurred following the treatment with 15 micromol/L ADMA.	N,N-dimethylarginine	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	396-400
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	20-23	C-X-C motif chemokine ligand 8	Homo sapiens	396-400
22194647-13	2011	Mapracorat inhibited eosinophil migration and IL-8 release from eosinophils or the release of IL-6, IL-8, CCL5/RANTES, and TNF-alpha from a human mast cell line with equal potency as dexamethasone, whereas it was clearly less potent than this glucocorticoid in inducing annexin I and CXCR4 expression on the human eosinophil surface; this was taken as a possible sign of glucocorticoid-dependent transactivation.	R-1,1,1-trifluoro-4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-4-methyl-2-(((2-methyl-5-quinolyl)amino)methyl)pentan-2-ol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
22194647-13	2011	Mapracorat inhibited eosinophil migration and IL-8 release from eosinophils or the release of IL-6, IL-8, CCL5/RANTES, and TNF-alpha from a human mast cell line with equal potency as dexamethasone, whereas it was clearly less potent than this glucocorticoid in inducing annexin I and CXCR4 expression on the human eosinophil surface; this was taken as a possible sign of glucocorticoid-dependent transactivation.	R-1,1,1-trifluoro-4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-4-methyl-2-(((2-methyl-5-quinolyl)amino)methyl)pentan-2-ol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
22219634-9	2011	The result of ELISA also showed that the release of IL-6 and IL-8 can be inhibited by high glucose, but these inhibitions were partly counteracted after pretreatment with anti-TLR2 and/or anti-TLR4 monoclonal antibody.	Glucose	91-98	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
21269946-7	2011	ADMA treatment also resulted in a dose-dependent increase of the levels of TNF-alpha and IL-8 in the culture supernatant of the macrophages, and the peak levels occurred following the treatment with 15 micromol/L ADMA.	N,N-dimethylarginine	213-217	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
21269946-8	2011	CONCLUSION: ADMA can up-regulate MIF expression and induce TNF-alpha and IL-8 secretion in THP-1 monocyte-derived macrophages.	N,N-dimethylarginine	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
21462088-6	2011	The molecular mechanism of garcinol"s action on PaCa cells was investigated by targeting signaling moieties involved in apoptosis (X-IAP, cIAP, caspase-3, 9, and PARP cleavage), transcription factor NF-kappaB, believed to contribute toward a chemoresistance phenotype in pancreatic tumors, and molecules associated with neovascularization and metastasis (MMP-9, VEGF, IL-8, and PGE(2)).	garcinol	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	368-372
20571097-8	2011	This could be confirmed ex vivo, as the prevalence of non-epitheloid phenotype of MC in the standard group was significantly higher with increasing PD duration and MC isolated from this group showed significantly higher levels of EMT-associated molecules including fibronectin, collagen I, VEGF, IL-8 and TGF-beta levels when compared with the low-GDP group.	Methylcholanthrene	164-166	C-X-C motif chemokine ligand 8	Homo sapiens	296-300
20571097-10	2011	In addition, the levels of EMT-associated molecules (fibronectin, VEGF and IL-8) increased in the standard but decreased in the low-GDP group.	Guanosine Diphosphate	132-135	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
20571097-12	2011	Accordingly, effluent MC with non-epitheloid morphology showed significantly lower levels of E-cadherin and greater levels of fibronectin, collagen I, VEGF and IL 8 when compared with MC with epitheloid phenotype.	Methylcholanthrene	22-24	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
21935477-10	2011	Microarray analysis of islets exposed to Imatinib for 4 hours revealed increased expression of the inflammatory genes IL-4R, TCF5, DR5, I-TRAF, I-CAM, HSP27 and IL-8.	Imatinib Mesylate	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
22194966-2	2011	This posttranslational modification of arginine was recently discovered on inflammatory chemokines including CXCL8 and CXCL10, and significantly reduced their biological activity.	Arginine	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	109-114
22039452-3	2011	Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
22039452-3	2011	Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	213-217
21594207-9	2011	Only one product with NaF as fluoride supplement showed both total and free fluoride concentrations above 1,000 ppm F-.	Fluorides	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	22-25
21594207-9	2011	Only one product with NaF as fluoride supplement showed both total and free fluoride concentrations above 1,000 ppm F-.	Fluorides	76-84	C-X-C motif chemokine ligand 8	Homo sapiens	22-25
21757966-6	2011	CAM treatment was more effective for IL-8(high) CRSnNP patients than for IL-8(low) CRSnNP patients (p &lt; 0.05).	Clarithromycin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
21757966-6	2011	CAM treatment was more effective for IL-8(high) CRSnNP patients than for IL-8(low) CRSnNP patients (p &lt; 0.05).	Clarithromycin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
22216191-0	2011	Mycobacterium abscessus glycopeptidolipid prevents respiratory epithelial TLR2 signaling as measured by HbetaD2 gene expression and IL-8 release.	glycopeptidolipid	24-41	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
22205926-3	2011	METHODOLOGY/PRINCIPAL FINDINGS: Corticosteroid sensitivity was determined by the dexamethasone ability to inhibit TNFalpha-induced IL-8 or LPS-induced TNFalpha production.	Dexamethasone	81-94	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
21935477-11	2011	The islet release of IL-8 was augmented in islets cultured over night in the presence of Imatinib.	Imatinib Mesylate	89-97	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
21904597-8	2011	The truncated forms CXCL8(2-77) and CXCL8(3-77) had higher affinity for heparin than CXCL8(1-77), a property important for the presentation of CXCL8 on endothelial layers.	Heparin	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	20-25
21904597-8	2011	The truncated forms CXCL8(2-77) and CXCL8(3-77) had higher affinity for heparin than CXCL8(1-77), a property important for the presentation of CXCL8 on endothelial layers.	Heparin	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	36-41
21904597-8	2011	The truncated forms CXCL8(2-77) and CXCL8(3-77) had higher affinity for heparin than CXCL8(1-77), a property important for the presentation of CXCL8 on endothelial layers.	Heparin	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	36-41
21904597-8	2011	The truncated forms CXCL8(2-77) and CXCL8(3-77) had higher affinity for heparin than CXCL8(1-77), a property important for the presentation of CXCL8 on endothelial layers.	Heparin	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	36-41
21738617-6	2011	Exposure of BMCs to CSE induced IL-8 and TGF-beta1 production, which was dependent on NF-kappaB and ERK1/2, but not on AKT.	bmcs	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
21826199-0	2011	Anti-inflammatory effect of fluvastatin on IL-8 production induced by Pseudomonas aeruginosa and Aspergillus fumigatus antigens in cystic fibrosis.	Fluvastatin	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
21826199-2	2011	Since recent research has identified the anti-inflammatory properties of statins (besides their lipid-lowering effects), we investigated the effect of fluvastatin on the production of the potent neutrophil chemoattractant chemokine, IL-8, in whole blood from CF patients, stimulated by Pseudomonas aeruginosa (LPS) and Aspergillus fumigatus (AFA) antigens.	Fluvastatin	151-162	C-X-C motif chemokine ligand 8	Homo sapiens	233-237
21826199-6	2011	Fluvastatin strongly decreased the levels of IL-8, in a concentration-dependent manner, in whole blood from CF patients.	Fluvastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
21633494-7	2011	We show that STBM can bind to monocytes and B cells and induce cytokine release (TNFalpha, MIP-1alpha, IL-1alpha, IL-1beta, IL-6, IL-8).	stbm	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
21625550-0	2011	Lycopene inhibits NF-kB-mediated IL-8 expression and changes redox and PPARgamma signalling in cigarette smoke-stimulated macrophages.	Lycopene	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
21625550-3	2011	The aim of this study was to investigate the role of lycopene on the production of the pro-inflammatory cytokine IL-8 induced by cigarette smoke and the possible mechanisms implicated.	Lycopene	53-61	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
21625550-6	2011	Lycopene pre-treatment resulted in a significant inhibition of CSE-induced IL-8 expression at both mRNA and protein levels.	Lycopene	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
21625550-13	2011	Taken together, our data indicate that lycopene prevented CSE-induced IL-8 production through a mechanism involving an inactivation of NF-kB.	Lycopene	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
21625550-15	2011	The ability of lycopene in inhibiting IL-8 production, NF-kB/p65 nuclear translocation, and redox signalling and in increasing PPARgamma expression was also found in isolated rat alveolar macrophages exposed to CSE.	Lycopene	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
21779360-4	2011	Our findings showed that pretreatment of HaCaT cells with NaHS (a donor of H(2)S) for 30 min before exposure to CoCl(2) for 24 h significantly attenuated CoCl(2)-induced injuries and inflammatory responses, evidenced by increases in cell viability and GSH level and decreases in ROS generation and secretions of IL-1beta, IL-6 and IL-8.	sodium bisulfide	58-62	C-X-C motif chemokine ligand 8	Homo sapiens	331-335
21779360-4	2011	Our findings showed that pretreatment of HaCaT cells with NaHS (a donor of H(2)S) for 30 min before exposure to CoCl(2) for 24 h significantly attenuated CoCl(2)-induced injuries and inflammatory responses, evidenced by increases in cell viability and GSH level and decreases in ROS generation and secretions of IL-1beta, IL-6 and IL-8.	Hydrogen Sulfide	75-80	C-X-C motif chemokine ligand 8	Homo sapiens	331-335
21779360-6	2011	Similar to the protective effect of H(2)S, both NS-398 (a selective COX-2 inhibitor) and PDTC (a selective NF-kappaB inhibitor) depressed not only CoCl(2)-induced cytotoxicity, but also the secretions of IL-1beta, IL-6 and IL-8.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	48-54	C-X-C motif chemokine ligand 8	Homo sapiens	223-227
21822181-7	2011	There was a significant negative correlation between levels of IL-8 and pH (r=-0.83, p&lt;0.05), and of IL-8 and glucose in pleural fluid (r=-0.61, p&lt;0.05).	Glucose	113-120	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
20932985-0	2011	Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-alpha via distinct NF-kappaB pathways in human nasal epithelial cells.	poly	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
20932985-0	2011	Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-alpha via distinct NF-kappaB pathways in human nasal epithelial cells.	Iodine	5-6	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
20932985-0	2011	Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-alpha via distinct NF-kappaB pathways in human nasal epithelial cells.	Carbon	7-8	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
20932985-5	2011	In hTERT-transfected HNECs, treatment with poly(I:C) significantly reduced expression of the tight junction protein JAM-A and induced secretion of proinflammatory cytokines IL-8 and TNF-alpha.	Poly I-C	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
20932985-6	2011	Both the reduction of JAM-A expression and the induction of secretion of IL-8 and TNF-alpha after treatment with poly(I:C) were modulated by distinct signal transduction pathways via EGFR, PI3K, and p38 MAPK and finally regulated by a TLR3-mediated NF-kappaB pathway.	poly	113-117	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
20932985-6	2011	Both the reduction of JAM-A expression and the induction of secretion of IL-8 and TNF-alpha after treatment with poly(I:C) were modulated by distinct signal transduction pathways via EGFR, PI3K, and p38 MAPK and finally regulated by a TLR3-mediated NF-kappaB pathway.	Carbon	120-121	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
25214996-16	2011	The level of serum IL-8 was positively correlated with white blood cell count and ISS score, and inversely correlated with oxygen index.	Oxygen	123-129	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
20615393-0	2010	Decoy oligodeoxyribonucleotides and peptide nucleic acids-DNA chimeras targeting nuclear factor kappa-B: inhibition of IL-8 gene expression in cystic fibrosis cells infected with Pseudomonas aeruginosa.	Oligodeoxyribonucleotides	6-31	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
20615393-5	2010	Here, we review the inhibitory effects of decoy oligodeoxyribonucleotides (ODNs) on expression of IL-8 gene and secretion of IL-8 by cystic fibrosis cells infected by Pseudomonas aeruginosa.	decoy oligodeoxyribonucleotides	42-73	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
20615393-5	2010	Here, we review the inhibitory effects of decoy oligodeoxyribonucleotides (ODNs) on expression of IL-8 gene and secretion of IL-8 by cystic fibrosis cells infected by Pseudomonas aeruginosa.	decoy oligodeoxyribonucleotides	42-73	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
20816778-9	2010	50% of the control, whereas EGCG provoked a decrease in the IL-6 and IL-8 over-secretion, by 50 and 60%, respectively.	epigallocatechin gallate	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
21162728-10	2010	A CYP1A1 inhibitor (alpha-naphthoflavone), nearly abolished the DEP-induced expression of IL-8 and COX-2.	alpha-naphthoflavone	20-40	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
21162728-12	2010	A p38 inhibitor (SB202190) strongly reduced DEP-induced expression of IL-6, IL-8 and COX-2, but only moderately affected the expression of CYP1A1.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
20923702-2	2010	This report concerns the strong proinflammatory action that a dietary oxysterol mixture and, to a lesser extent, an identical concentration of unoxidized cholesterol exert on CaCo-2 colonic epithelial cells by up-regulating both expression and synthesis of interleukin 8.	Oxysterols	70-79	C-X-C motif chemokine ligand 8	Homo sapiens	257-270
20943792-7	2010	RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1.	Quercetin	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
20943792-7	2010	RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1.	Resveratrol	43-52	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
20943792-7	2010	RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1.	Quercetin	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
20889674-3	2010	We particularly focused on the effects of LTD4 on release of heparin-binding EGF-like factor (HB-EGF) and IL-8 (CXCL8), a potent neutrophil chemoattractant that may be released downstream of EGFR activation.	Leukotriene D4	42-46	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
20729385-7	2010	Pretreatment with budesonide, a currently used inhaled corticosteroid, decreased LPS-induced expression of TNF-alpha, IL-6, and IL-8, and reduced LPS-induced neutrophilia by ~84%.	Budesonide	18-28	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
20889674-3	2010	We particularly focused on the effects of LTD4 on release of heparin-binding EGF-like factor (HB-EGF) and IL-8 (CXCL8), a potent neutrophil chemoattractant that may be released downstream of EGFR activation.	Leukotriene D4	42-46	C-X-C motif chemokine ligand 8	Homo sapiens	112-117
20049553-3	2010	Here, we demonstrated that middle (1.0 mmol/L) and high (10.0 mmol/L) concentrations of sodium fluoride (NaF) significantly inhibited hair follicle elongation in vitro, but low NaF (0.1 mmol/L) showed little influence.	Sodium Fluoride	88-103	C-X-C motif chemokine ligand 8	Homo sapiens	105-108
20049553-4	2010	Moreover, treatment with high levels of NaF resulted in a marked increase in terminal dUTP nick end labeling-positive cells in the outer layer of the outer root sheath, the dermal sheath, and the lower bulb matrix surrounding dermal papilla.	deoxyuridine triphosphate	86-90	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
20049553-6	2010	Additionally, the presence of selenium considerably antagonized the effects of middle NaF on hair follicles, with regard to either the suppression of hair growth or the induction of oxidative stress and apoptosis.	Selenium	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	86-89
21169142-11	2010	Release of C3a was attenuated in the fenoldopam group (P = .002), and release of IL-6 and IL-8 was attenuated in the postoperative period in the fenoldopam group (P = .012 and .015, respectively).	Fenoldopam	145-155	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
20198424-10	2010	IL-8 mRNA expression in the esophageal mucosa of patients with rebamipide was significantly decreased compared with that of patients without rebamipide.	rebamipide	63-73	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
20198424-10	2010	IL-8 mRNA expression in the esophageal mucosa of patients with rebamipide was significantly decreased compared with that of patients without rebamipide.	rebamipide	141-151	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
20826566-10	2010	Furthermore, dexamethasone-enhanced ATP induction of adhesion molecule transcription and augmented the release of IL-8.	Dexamethasone	13-26	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
20384691-0	2010	Influence of high dose tumescent local anaesthesia with prilocaine on systemic interleukin (IL)-6, IL-8 and tumour necrosis factor-alpha.	Prilocaine	56-66	C-X-C motif chemokine ligand 8	Homo sapiens	99-136
20607584-0	2010	Rebamipide inhibits tumor necrosis factor-alpha-induced interleukin-8 expression by suppressing the NF-kappaB signal pathway in human umbilical vein endothelial cells.	rebamipide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
20607584-1	2010	OBJECTIVE: This study was designed to identify the inhibitory effect of rebamipide on tumor necrosis factor-alpha (TNF-alpha)-induced interleukin-8 (IL-8) production and nuclear factor-kappaB (NF-kappaB) activation in human umbilical vein endothelial cells (HUVECs).	rebamipide	72-82	C-X-C motif chemokine ligand 8	Homo sapiens	134-147
20607584-1	2010	OBJECTIVE: This study was designed to identify the inhibitory effect of rebamipide on tumor necrosis factor-alpha (TNF-alpha)-induced interleukin-8 (IL-8) production and nuclear factor-kappaB (NF-kappaB) activation in human umbilical vein endothelial cells (HUVECs).	rebamipide	72-82	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
20607584-6	2010	RESULTS: We found that rebamipide decreased the expression of IL-8 in the dose-dependent manner under the treatment with TNF-alpha 10 ng/ml.	rebamipide	23-33	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
20607584-9	2010	CONCLUSION: Rebamipide suppresses TNF-alpha-induced IL-8 production through (1) inhibition of IkappaB-alpha phosphorylation in the cytoplasm and (2) blockage of NF-kappaB p65 protein transport into the nucleus.	rebamipide	12-22	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
20607584-10	2010	We suggest that the anti-inflammatory effect of rebamipide is related to the down-regulation of IL-8 expression that is important in endothelial inflammation.	rebamipide	48-58	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
20976506-0	2010	Suppressive effects of sivelestat on interleukin 8 and TNF-alpha production from LPS-stimulated granulocytes in whole blood culture.	sivelestat	23-33	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
20976506-9	2010	CONCLUSION: Suppression of granulocytic production of IL-8 and TNF-alpha by sivelestat suggests that this drug may be useful for treatment of morbid conditions involving IL-8 and TNF-alpha at onset.	sivelestat	76-86	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
20976506-9	2010	CONCLUSION: Suppression of granulocytic production of IL-8 and TNF-alpha by sivelestat suggests that this drug may be useful for treatment of morbid conditions involving IL-8 and TNF-alpha at onset.	sivelestat	76-86	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
20801891-8	2010	Dexamethasone and resveratrol inhibited concentration-dependently TNFalpha-induced IL-8, GM-CSF, and VEGF release.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
20801891-8	2010	Dexamethasone and resveratrol inhibited concentration-dependently TNFalpha-induced IL-8, GM-CSF, and VEGF release.	Resveratrol	18-29	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
20801891-9	2010	For IL-8 and GM-CSF efficiency of dexamethasone was NS &gt; S &gt; COPD.	Dexamethasone	34-47	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
20801891-10	2010	That of resveratrol was NS = S = COPD for IL-8 and NS = S &lt; COPD for GM-CSF.	Resveratrol	8-19	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
21179282-8	2010	Treatment with inhibitors of nuclear factor-kappaB (NF-kappaB), i.e., pyrrolidine dithiocarbamate and parthenolide, abrogated the stimulatory effect of poly (I:C) on the production of VEGF and IL-8 in RA FLS.	pyrrolidine dithiocarbamic acid	70-97	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
21179282-8	2010	Treatment with inhibitors of nuclear factor-kappaB (NF-kappaB), i.e., pyrrolidine dithiocarbamate and parthenolide, abrogated the stimulatory effect of poly (I:C) on the production of VEGF and IL-8 in RA FLS.	parthenolide	102-114	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
20725767-5	2010	NaF treatment, which increased the rate of apoptosis in a time- and dose-dependent manner, also increased the levels of inositol mono- and bis-phosphates and drastically reduced the levels of inositol tris- and tetrakis-phosphates.	inositol mono- and bis-phosphates	120-153	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
20725767-5	2010	NaF treatment, which increased the rate of apoptosis in a time- and dose-dependent manner, also increased the levels of inositol mono- and bis-phosphates and drastically reduced the levels of inositol tris- and tetrakis-phosphates.	inositol tris- and tetrakis-phosphates	192-230	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
20725767-6	2010	Prior treatment with antimycin A, a strategy used to reverse the NaF-induced accumulations of higher InsPs, partially reduced the effects of NaF on apoptosis as well as the levels of lower InsPs.	Antimycin A	21-32	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
20725767-6	2010	Prior treatment with antimycin A, a strategy used to reverse the NaF-induced accumulations of higher InsPs, partially reduced the effects of NaF on apoptosis as well as the levels of lower InsPs.	Antimycin A	21-32	C-X-C motif chemokine ligand 8	Homo sapiens	141-144
20657019-1	2010	BACKGROUND: The authors previously reported that human ocular surface epithelium expressed TLR3 and that its ligand polyI:C stimulated the secretion of IL-6, IL-8 and IFN-beta.	Poly I-C	116-123	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
21442075-0	2010	Dexamethasone-induced apoptosis of freshly isolated human nasal epithelial cells concomitant with abrogation of IL-8 production.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
21442075-11	2010	Dexamethasone induced apoptosis of hNECs concomitant with abrogation of IL-8 production by hNECs.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
21442075-13	2010	Dexamethasone induces apoptosis of hNECs and abrogates IL-8 production.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
20677965-7	2010	RESULTS: Only coated samples with the highest fluoride content (group D, 0.4 g of NaF) were able to release fluoride at therapeutic levels.	Fluorides	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
20677965-8	2010	When fluoride release from coated and uncoated samples with the same amount of NaF were compared, it was shown that the dip-coating technique resulted in a fluoride release in a controlled manner while eliminating the initial burst effect.	3,5-diisopropylsalicylic acid	120-123	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
20600865-5	2010	In the present study, we show that exposure of endothelial cells to low magnesium increases the secretion of RANTES, interleukin 8 and platelet derived growth factor BB, all important players in atherogenesis.	Magnesium	72-81	C-X-C motif chemokine ligand 8	Homo sapiens	117-130
20826776-4	2010	Norepinephrine (NE) treatment of ovarian cancer cells resulted in a 250-300% increase in IL8 protein and 240-320% increase in its mRNA levels.	Norepinephrine	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	89-92
20826776-8	2010	Promoter deletion analyses suggested that AP1 transcription factors might mediate catecholamine-stimulated up-regulation of IL8.	Catecholamines	82-95	C-X-C motif chemokine ligand 8	Homo sapiens	124-127
20826776-11	2010	This enhanced tumor growth was completely blocked by IL8 or FosB gene silencing using 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine nanoliposomes.	1,2-oleoylphosphatidylcholine	86-131	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
20632048-0	2010	Nickel induces oxidative burst, NF-kappaB activation and interleukin-8 production in human neutrophils.	Nickel	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	57-70
20949640-10	2010	Human islets also responded to beta-GalCer (10 microg/mL) by secreting TNFalpha, IL-1beta and IL-8, whereas sulfatide partly inhibited the effect of LPS.	beta-GalCer	31-42	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
20518825-3	2010	In this study, we investigated the effects of interleukin-8 (IL-8), a known neutrophil chemoattractant, on lipopolysaccharide (LPS) -induced reactive oxygen species (ROS) production by endothelial cells, and its significance in the pathogenesis of LPS-mediated sepsis.	Reactive Oxygen Species	141-164	C-X-C motif chemokine ligand 8	Homo sapiens	46-59
20518825-3	2010	In this study, we investigated the effects of interleukin-8 (IL-8), a known neutrophil chemoattractant, on lipopolysaccharide (LPS) -induced reactive oxygen species (ROS) production by endothelial cells, and its significance in the pathogenesis of LPS-mediated sepsis.	Reactive Oxygen Species	141-164	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
20518825-3	2010	In this study, we investigated the effects of interleukin-8 (IL-8), a known neutrophil chemoattractant, on lipopolysaccharide (LPS) -induced reactive oxygen species (ROS) production by endothelial cells, and its significance in the pathogenesis of LPS-mediated sepsis.	Reactive Oxygen Species	166-169	C-X-C motif chemokine ligand 8	Homo sapiens	46-59
20518825-3	2010	In this study, we investigated the effects of interleukin-8 (IL-8), a known neutrophil chemoattractant, on lipopolysaccharide (LPS) -induced reactive oxygen species (ROS) production by endothelial cells, and its significance in the pathogenesis of LPS-mediated sepsis.	Reactive Oxygen Species	166-169	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
20518825-4	2010	The results revealed that IL-8 directly induced ROS production in human umbilical vein endothelial cells (HUVECs), and also mediated LPS-induced ROS production by HUVECs.	Reactive Oxygen Species	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
20518825-4	2010	The results revealed that IL-8 directly induced ROS production in human umbilical vein endothelial cells (HUVECs), and also mediated LPS-induced ROS production by HUVECs.	Reactive Oxygen Species	145-148	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
20732995-6	2010	MIMLh5 efficiently reduced the induction of interleukin-6 (IL-6), IL-8, and tumor necrosis factor alpha (TNF-alpha), in a dose-dependent manner.	mimlh5	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
20632048-6	2010	In addition, nickel was shown to activate NF-kappaB and to induce the production of IL-8 in these cells.	Nickel	13-19	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
20889551-8	2010	Taken together, the results indicate that ribotoxin-induced CHOP protein is positively associated with production of proinflammatory cytokine IL-8, but it downregulates PPARgamma action, subsequently allowing the cytosolic translocation of HuR protein and stabilization of IL-8 mRNA in gut epithelial cells.	ribotoxin	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
20386089-9	2010	The VDR agonist elocalcitol partially reverts COX-2 and IL-8 mRNA upregulation induced by a pro-inflammatory cytokine mixture (IL-17, interferon-gamma, tumor necrosis factor-alpha) and inhibits cell migration in urethral cells.	BXL628	16-27	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
20822922-13	2010	Reverse transcription polymerase chain reaction for IL-8 messenger RNA was significantly higher in controls during the reperfusion period than in the NAC group (p = 0.001).	Acetylcysteine	150-153	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
21256400-7	2010	The test rinse significantly inhibited enamel surface softening versus the three rinses containing &lt;=112 ppm fluoride (as NaF) at 30 min (p&lt;0.05), but was not statistically significantly different from the 225 ppm fluoride rinse.	Fluorides	112-120	C-X-C motif chemokine ligand 8	Homo sapiens	125-128
20889551-8	2010	Taken together, the results indicate that ribotoxin-induced CHOP protein is positively associated with production of proinflammatory cytokine IL-8, but it downregulates PPARgamma action, subsequently allowing the cytosolic translocation of HuR protein and stabilization of IL-8 mRNA in gut epithelial cells.	ribotoxin	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	273-277
20816994-6	2010	KEY FINDINGS: The release of IL-8 and TNFalpha from THP-1 and HL-60 cells was significantly increased by treatment with terbinafine but not by fluconazole, suggesting that terbinafine can stimulate monocytes and increase the pro-inflammatory cytokine release.	Terbinafine	120-131	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
20935477-8	2010	In vitro, ATROSAB inhibited typical TNF-mediated responses like apoptosis induction and activation of NFkappaB-dependent gene expression such as IL-6 and IL-8 production.	atrosab	10-17	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
20456615-9	2010	IL-6 and IL-8 production was increased by Pam(3) CSK(4) , flagellin, Poly I:C, and imiquimod, but not lipopolysaccharide (LPS).	Poly I-C	69-77	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
20512787-4	2010	After 24 h, glutamine inhibited IL-8 production significantly (p&lt;0.05) at 2, 5 and 10 mM (to 82, 73 and 72% of control), whereas leucine reduced IL-8 production significantly only at 10 mM (66%) and proline at 5 and 10 mM (71 and 52%).	Glutamine	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
20512787-4	2010	After 24 h, glutamine inhibited IL-8 production significantly (p&lt;0.05) at 2, 5 and 10 mM (to 82, 73 and 72% of control), whereas leucine reduced IL-8 production significantly only at 10 mM (66%) and proline at 5 and 10 mM (71 and 52%).	Leucine	132-139	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
20512787-8	2010	Our results indicate that glutamine, leucine and proline attenuate IL-8 production, probably through inhibition of NF-kappaB, and that they increase Akt phosphorylation in HepG2 cells.	Glutamine	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
20512787-8	2010	Our results indicate that glutamine, leucine and proline attenuate IL-8 production, probably through inhibition of NF-kappaB, and that they increase Akt phosphorylation in HepG2 cells.	Leucine	37-44	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
20512787-8	2010	Our results indicate that glutamine, leucine and proline attenuate IL-8 production, probably through inhibition of NF-kappaB, and that they increase Akt phosphorylation in HepG2 cells.	Proline	49-56	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
20816994-6	2010	KEY FINDINGS: The release of IL-8 and TNFalpha from THP-1 and HL-60 cells was significantly increased by treatment with terbinafine but not by fluconazole, suggesting that terbinafine can stimulate monocytes and increase the pro-inflammatory cytokine release.	Terbinafine	172-183	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
20816994-8	2010	Pretreatment with a MAP kinase/ERK kinase (MEK)1/2 inhibitor U0126 significantly suppressed the increase of IL-8 and TNFalpha levels by terbinafine treatment in THP-1 cells, but p38 MAPK inhibitor SB203580 did not.	U 0126	61-66	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
20816994-8	2010	Pretreatment with a MAP kinase/ERK kinase (MEK)1/2 inhibitor U0126 significantly suppressed the increase of IL-8 and TNFalpha levels by terbinafine treatment in THP-1 cells, but p38 MAPK inhibitor SB203580 did not.	Terbinafine	136-147	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
20816994-9	2010	These results suggested that an ERK1/2 pathway plays an important role in the release of IL-8 and TNFalpha in THP-1 cells treated with terbinafine.	Terbinafine	135-146	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
20841991-2	2010	Lopinavir, the most potent inducer of interleukin (IL)-8 expression, also inhibited dsRNA-induced monocyte chemotactic protein 1 expression.	Lopinavir	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	38-56
21042538-5	2010	Stimulation with each agonist (Pam(3)CSK(4) for TLR2, LPS for TLR4, Tri-DAP for NOD1, and MDP for NOD2) led to IL-8 production in hUCB-MSC, suggesting the expressed receptors are functional in hUCB-MSC.	L-Ala-gamma-D-Glu-meso-diaminopimelic acid	68-75	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
20841991-3	2010	Further analyses demonstrated that nuclear factor-kappaB is required for lopinavir"s induction of IL-8.	Lopinavir	73-82	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
21042414-1	2010	5-Androstene-3beta,7beta,17beta-triol (beta-AET), an active metabolite of dehydroepiandrosterone (DHEA), reversed glucocorticoid (GC)-induced suppression of IL-6, IL-8 and osteoprotegerin production by human osteoblast-like MG-63 cells and promoted osteoblast differentiation of human mesenchymal stem cells (MSCs).	5-androstene-3beta	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
20958969-12	2010	Exposure of C3A cells to PA up-regulated IL-8 and TLR-4 expression.	Palmitic Acid	25-27	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
21042414-1	2010	5-Androstene-3beta,7beta,17beta-triol (beta-AET), an active metabolite of dehydroepiandrosterone (DHEA), reversed glucocorticoid (GC)-induced suppression of IL-6, IL-8 and osteoprotegerin production by human osteoblast-like MG-63 cells and promoted osteoblast differentiation of human mesenchymal stem cells (MSCs).	7beta	19-24	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
21042414-1	2010	5-Androstene-3beta,7beta,17beta-triol (beta-AET), an active metabolite of dehydroepiandrosterone (DHEA), reversed glucocorticoid (GC)-induced suppression of IL-6, IL-8 and osteoprotegerin production by human osteoblast-like MG-63 cells and promoted osteoblast differentiation of human mesenchymal stem cells (MSCs).	17beta-triol	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
21042414-1	2010	5-Androstene-3beta,7beta,17beta-triol (beta-AET), an active metabolite of dehydroepiandrosterone (DHEA), reversed glucocorticoid (GC)-induced suppression of IL-6, IL-8 and osteoprotegerin production by human osteoblast-like MG-63 cells and promoted osteoblast differentiation of human mesenchymal stem cells (MSCs).	5-androstene-3,7,17-triol	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
21042414-1	2010	5-Androstene-3beta,7beta,17beta-triol (beta-AET), an active metabolite of dehydroepiandrosterone (DHEA), reversed glucocorticoid (GC)-induced suppression of IL-6, IL-8 and osteoprotegerin production by human osteoblast-like MG-63 cells and promoted osteoblast differentiation of human mesenchymal stem cells (MSCs).	Dehydroepiandrosterone	74-96	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
21042414-1	2010	5-Androstene-3beta,7beta,17beta-triol (beta-AET), an active metabolite of dehydroepiandrosterone (DHEA), reversed glucocorticoid (GC)-induced suppression of IL-6, IL-8 and osteoprotegerin production by human osteoblast-like MG-63 cells and promoted osteoblast differentiation of human mesenchymal stem cells (MSCs).	Dehydroepiandrosterone	98-102	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
20731619-10	2010	Inactivation of ERK signaling pathways by PD98059 effectively blocked IL-6, -8, and -10 induction by WTC2.5; the p38 kinase inhibitor SB203580 significantly decreased induction of IL-8 and -10.	SB 203580	134-142	C-X-C motif chemokine ligand 8	Homo sapiens	180-192
20139132-6	2010	The results of the potentiodynamic curve showed that most brands of metal brackets were easily corroded in the NaF and pH 4 environments, while the NiTi and stainless steel wires were easily corroded in the pH 4 artificial saliva.	Metals	68-73	C-X-C motif chemokine ligand 8	Homo sapiens	111-114
20678598-0	2010	Ginsenoside Rb1 and paeoniflorin inhibit transient receptor potential vanilloid-1-activated IL-8 and PGE2 production in a human keratinocyte cell line HaCaT.	peoniflorin	20-32	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
21122279-0	2010	Montelukast reduces eosinophilic inflammation by inhibiting both epithelial cell cytokine secretion (GM-CSF, IL-6, IL-8) and eosinophil survival.	montelukast	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
20939898-6	2010	ISO-1 ((S, R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester), a small-molecule inhibitor of MIF, significantly decreased IL-6, IL-8, and TNF-alpha production in a time- and dose-dependent manner in human peripheral blood cells infected with V. vulnificus.	(s, r)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester	7-82	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
20224070-4	2010	METHODS: Corticosteroid sensitivity was determined as the 50% inhibitory concentration of dexamethasone on tumor necrosis factor-alpha-induced interleukin-8 release in peripheral blood mononuclear cells from patients with COPD (n = 17) and compared with that of nonsmoking (n = 8) and smoking (n = 7) control subjects.	Dexamethasone	90-103	C-X-C motif chemokine ligand 8	Homo sapiens	143-156
20339855-8	2010	RESULTS: 7beta-OH and 7KC triggered a caspase-independent cell death process associated with the presence of multilamellar cytoplasmic structures evocating phospholipidosis, increased ROS production, and IL-8 secretion.	cholest-5-en-3 beta,7 alpha-diol	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
20339855-12	2010	25-OH induced IL-8 secretion through the MEK/ERK1/2 signaling pathway, and Rsv showed cytoprotective activities and inhibited VEGF secretion.	25-hydroxycholesterol	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
20678598-3	2010	It has been shown that GRb1 and PF inhibited the productions of IL-8 and PGE2 induced by capsaicin (CAP) in HaCaT cells and HEK 293T-TRPV1 cells (which were transgenic and overexpressed TRPV1) but had no effect on HEK 293T mock cells (p&lt;0.05).	Capsaicin	89-98	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
21535503-5	2010	Our data demonstrated that kaempferol significantly inhibited the lipopolysaccharide (LPS)-induced production of monocyte-derived chemokine (MDC), interferon gamma-induced protein 10 (IP-10), and interleukin-8 (IL-8) in THP-1 cells.	kaempferol	27-37	C-X-C motif chemokine ligand 8	Homo sapiens	196-209
21535503-5	2010	Our data demonstrated that kaempferol significantly inhibited the lipopolysaccharide (LPS)-induced production of monocyte-derived chemokine (MDC), interferon gamma-induced protein 10 (IP-10), and interleukin-8 (IL-8) in THP-1 cells.	kaempferol	27-37	C-X-C motif chemokine ligand 8	Homo sapiens	211-215
20397192-7	2010	The most important mechanism by which MG and GL induced IL-8 secretion was the generation of superoxide anions which was confirmed by the inhibition of the cytosolic NADPH oxidase with diphenyl iodonium (DPI) or by application of superoxide dismutase (SOD).	Superoxides	93-110	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
19864123-2	2010	Mechanisms of CGN-induced nuclear factor kappaB and interleukin-8 (IL-8) stimulation include an immune-mediated pathway involving toll-like receptor 4 (TLR4) and B-cell lymphoma/leukemia 10 (BCL10) and a reactive oxygen species (ROS)-mediated pathway.	Reactive Oxygen Species	204-227	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
19864123-2	2010	Mechanisms of CGN-induced nuclear factor kappaB and interleukin-8 (IL-8) stimulation include an immune-mediated pathway involving toll-like receptor 4 (TLR4) and B-cell lymphoma/leukemia 10 (BCL10) and a reactive oxygen species (ROS)-mediated pathway.	Reactive Oxygen Species	229-232	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
21103419-2	2010	Upon exposure to HCl, inflammation of the esophagus begins with activation of the transient receptor potential channel vanilloid subfamily member-1 (TRPV1) in the mucosa, and production of IL-8, substance P (SP), calcitonin gene related peptide (CGRP) and platelet activating factor (PAF).	Hydrochloric Acid	17-20	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
20828314-4	2010	To provide insight into the biological effects of tetrahydropalmatine, we examined its influence on lipopolysaccharide (LPS)-induced interleukin (IL)-8 production in the human monocytic cell line THP-1.	tetrahydropalmatine	50-69	C-X-C motif chemokine ligand 8	Homo sapiens	133-151
20828314-6	2010	Tetrahydropalmatine inhibited LPS-induced IL-8 production in a dose-dependent manner.	tetrahydropalmatine	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
20828314-7	2010	Furthermore, tetrahydropalmatine inhibited extracellular signal-regulated kinase and p38 MAPK phosphorylation, which suggests that tetrahydropalmatine inhibits IL-8 secretion by blocking MAPK phosphorylation.	tetrahydropalmatine	13-32	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
20828314-7	2010	Furthermore, tetrahydropalmatine inhibited extracellular signal-regulated kinase and p38 MAPK phosphorylation, which suggests that tetrahydropalmatine inhibits IL-8 secretion by blocking MAPK phosphorylation.	tetrahydropalmatine	131-150	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
20397192-0	2010	Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38.	carbonyl compounds	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
20397192-0	2010	Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38.	Glyoxal	25-32	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
20397192-7	2010	The most important mechanism by which MG and GL induced IL-8 secretion was the generation of superoxide anions which was confirmed by the inhibition of the cytosolic NADPH oxidase with diphenyl iodonium (DPI) or by application of superoxide dismutase (SOD).	diphenyliodonium	204-207	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
20397192-0	2010	Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38.	Superoxides	99-115	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
20397192-3	2010	Hence, we investigated the impact of mitogen-activated protein kinases (MAPK) and nuclear factor kappa B (NF-kappaB) on IL-8 production by human intestinal cells (Caco-2 and HT-29) after stimulation by MG and GL.	Pyruvaldehyde	202-204	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
20397192-7	2010	The most important mechanism by which MG and GL induced IL-8 secretion was the generation of superoxide anions which was confirmed by the inhibition of the cytosolic NADPH oxidase with diphenyl iodonium (DPI) or by application of superoxide dismutase (SOD).	Pyruvaldehyde	38-40	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
20397192-7	2010	The most important mechanism by which MG and GL induced IL-8 secretion was the generation of superoxide anions which was confirmed by the inhibition of the cytosolic NADPH oxidase with diphenyl iodonium (DPI) or by application of superoxide dismutase (SOD).	Glyoxal	45-47	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
20397192-8	2010	Our data suggest that multiple pathways were simultaneously activated; however, superoxide dependent MAPK p38 activation seems to be the most dominant pathway for IL-8 secretion in intestinal cells.	Superoxides	80-90	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
20538801-4	2010	WPBs could also contain tPA, and in IL-1beta-treated cells, IL-8, IL-6, MCP-1, and GRO-alpha, and were the primary source for histamine or ionomycin-stimulated secretion of these molecules.	Ionomycin	139-148	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
20633634-3	2010	IL-8 secretion and PGE-2 synthesizing capacity were dose-dependently upregulated in differentiated Caco-2 cells exposed to DON during 24h, reaching an increase of ~25 and 1.7-fold respectively, whereas transcript level of IL-8 and COX-2 were increased by ~40 and 17-fold.	deoxynivalenol	123-126	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
20633634-3	2010	IL-8 secretion and PGE-2 synthesizing capacity were dose-dependently upregulated in differentiated Caco-2 cells exposed to DON during 24h, reaching an increase of ~25 and 1.7-fold respectively, whereas transcript level of IL-8 and COX-2 were increased by ~40 and 17-fold.	deoxynivalenol	123-126	C-X-C motif chemokine ligand 8	Homo sapiens	222-226
20633634-6	2010	IL-8 secretion and PGE-2 synthesizing capacity increased respectively by ~15 and 2-fold after chronic 21 day incubation with DON (50 ng/ml).	deoxynivalenol	125-128	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
20941359-8	2010	Two of these genes, CEACAM1 and MMP8, possibly inhibited by methylprednisolone through IL8, were both found to be over-expressed in non-responsive patients.	Methylprednisolone	60-78	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
20875145-7	2010	Pretreatment with GF109203X, a protein kinase C (PKC) inhibitor, completely normalized the effect of methacholine on CSE-induced IL-8 secretion, whereas PMA, a PKC activator, mimicked the effects of methacholine, inducing IL-8 secretion and augmenting the effects of CSE.	bisindolylmaleimide I	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
20875145-7	2010	Pretreatment with GF109203X, a protein kinase C (PKC) inhibitor, completely normalized the effect of methacholine on CSE-induced IL-8 secretion, whereas PMA, a PKC activator, mimicked the effects of methacholine, inducing IL-8 secretion and augmenting the effects of CSE.	bisindolylmaleimide I	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	222-226
20875145-7	2010	Pretreatment with GF109203X, a protein kinase C (PKC) inhibitor, completely normalized the effect of methacholine on CSE-induced IL-8 secretion, whereas PMA, a PKC activator, mimicked the effects of methacholine, inducing IL-8 secretion and augmenting the effects of CSE.	Methacholine Chloride	101-113	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
20875145-10	2010	CONCLUSIONS: We conclude that muscarinic receptors facilitate CSE-induced IL-8 secretion by hASMc via PKC dependent activation of IkappaBalpha and ERK1/2.	hasmc	92-97	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
20713890-4	2010	Activation of TLR9 by viral DNA requires endosomal maturation because pretreatment of monocytes with chloroquine strongly reduced IL-8 secretion.	Chloroquine	101-112	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
20722440-0	2010	Oenothera paradoxa defatted seeds extract and its bioactive component penta-O-galloyl-beta-D-glucose decreased production of reactive oxygen species and inhibited release of leukotriene B4, interleukin-8, elastase, and myeloperoxidase in human neutrophils.	penta-o-galloyl-beta-d-glucose	70-100	C-X-C motif chemokine ligand 8	Homo sapiens	190-213
20722440-8	2010	The extract and especially penta-O-galloyl-beta-D-glucose significantly inhibit elastase, myeloperoxidase IL-8, and LTB4 release with an IC50 for penta-O-galloyl-beta-D-glucose of 17+-1, 15+-1, 6.5+-2.5, and around 20 muM, respectively.	penta-o-galloyl-beta-d-glucose	27-57	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
20800791-8	2010	CraA-induced IL-8 secretion can be blocked by serine protease inhibitors, phenylmethane sulfonyl fluoride, and aprotinin but not by other protease inhibitors.	craa	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
20595617-8	2010	The H(2)O(2)-mediated potentiation of IL-8 production required the activity of p38, tyrosine kinases, phospholipase Cgamma, and intracellular calcium, but not protein kinase C or protein kinase D. H(2)O(2) prolonged and augmented NF-kappaB activation by flagellin.	Calcium	142-149	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
20696864-4	2010	Surprisingly, however, whereas mRNA expression and cellular release of TNF-alpha, the beta form of pro-IL-1 (IL-1beta), and IL-6 were inhibited by the leptomycin B-induced nuclear IkappaBalpha, IL-8 mRNA expression and cellular release were not significantly affected.	leptomycin B	151-163	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
20800791-11	2010	Furthermore, ERK1/2 (U0126) and JNK (SP600125) inhibitors inhibited CraA-induced IL-8 secretion by 100% and 45%, respectively.	U 0126	21-26	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
20800791-11	2010	Furthermore, ERK1/2 (U0126) and JNK (SP600125) inhibitors inhibited CraA-induced IL-8 secretion by 100% and 45%, respectively.	pyrazolanthrone	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
20800791-8	2010	CraA-induced IL-8 secretion can be blocked by serine protease inhibitors, phenylmethane sulfonyl fluoride, and aprotinin but not by other protease inhibitors.	4-toluenesulfonyl fluoride	74-105	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
20431935-7	2010	Conversely, the promoting effect of the variant allele of the IL-8 polymorphism was more remarkable in subjects with low plasma levels of Lutein/zeaxanthin, beta-cryptoxanthin, and beta-carotene (&lt;median) [e.g., OR (95% CI): 2.44 (1.08, 5.75) (AT/TT vs. AA) for beta-carotene].	Beta-Cryptoxanthin	157-175	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
20595649-4	2010	In vitro, Pb induced an increase in interleukin 8 production and secretion by vascular endothelial cells.	Lead	10-12	C-X-C motif chemokine ligand 8	Homo sapiens	36-49
20431935-7	2010	Conversely, the promoting effect of the variant allele of the IL-8 polymorphism was more remarkable in subjects with low plasma levels of Lutein/zeaxanthin, beta-cryptoxanthin, and beta-carotene (&lt;median) [e.g., OR (95% CI): 2.44 (1.08, 5.75) (AT/TT vs. AA) for beta-carotene].	beta Carotene	181-194	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
20431935-7	2010	Conversely, the promoting effect of the variant allele of the IL-8 polymorphism was more remarkable in subjects with low plasma levels of Lutein/zeaxanthin, beta-cryptoxanthin, and beta-carotene (&lt;median) [e.g., OR (95% CI): 2.44 (1.08, 5.75) (AT/TT vs. AA) for beta-carotene].	beta Carotene	265-278	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
20678032-6	2010	RESULTS: Our magnetic immunoassay could detect four attomoles of model proteins (hIL-8, hIgE) in phosphate buffer without BF separation.	Phosphates	97-106	C-X-C motif chemokine ligand 8	Homo sapiens	81-86
20920411-8	2010	RESULTS: Polyethylene occlusion alone with abrupt removal induced IL-8 and IL-1alpha levels similar to or exceeding that of SLS.	Polyethylene	9-21	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
20920411-10	2010	CONCLUSION: Removal of occlusion with polyethylene film up-regulates the inflammatory cytokines IL-8, IL-1alpha, and IL-1RA in patients with AD.	Polyethylene	38-50	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
20095806-0	2010	Long-term effect of high doses glucocorticosteroids on mRNA expression for IL-6 and IL-8 in relapsed multiple sclerosis patients.	glucocorticosteroids	31-51	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
20450371-5	2010	RESULTS: Subjects who presented generalized AgP have a higher frequency of hypomethylation of the IL8 gene promoter in oral epithelium cells than that of controls (86.5% in the generalized AgP group versus 62% in the control group; P = 0.016; chi(2) test).	agp	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	98-101
20816188-8	2010	Atopic and atopic asthmatic subjects had increased sputum neutrophil numbers and IL-8 levels after ozone exposure; values did not significantly change in healthy volunteers.	Ozone	99-104	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
20525739-5	2010	In comparison with chemokine production rate, the CXCL8 and CXCL10 production rates were significantly higher in pSS than in non-SS sicca controls (P &lt; 0.01 by the Mann-Whitney test).	pss	113-116	C-X-C motif chemokine ligand 8	Homo sapiens	50-55
20553837-4	2010	Further, AexU prevented phosphorylation of c-Jun, JNK and IkappaBalpha and inhibited IL-6 and IL-8 secretion from HeLa cells.	aexu	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
20812134-5	2010	In addition, ROC induces a significant decrease in ICAM expression and IL-8 release.	Saquinavir	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
21038022-13	2010	Erythromycin given in group II decreased the levels of IL-8 and ICAM-1.	Erythromycin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
20840147-8	2010	However, IL-8 induction was inhibited by small-interfering RNA against TLR5 or by treating flagella with disialoganglioside-GD1a, a TLR5 blocker.	sialogangliosides	105-123	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
20347984-2	2010	The aim of this study was to evaluate the effect in cell culture of the third generation DHP-CA Manidipine on the release of interleukin-6 (IL-6) and interleukin-8 (IL-8) from human endothelial cells and human macrophages, in response to different pro-inflammatory signals.	dhp-ca manidipine	89-106	C-X-C motif chemokine ligand 8	Homo sapiens	150-163
20347984-2	2010	The aim of this study was to evaluate the effect in cell culture of the third generation DHP-CA Manidipine on the release of interleukin-6 (IL-6) and interleukin-8 (IL-8) from human endothelial cells and human macrophages, in response to different pro-inflammatory signals.	dhp-ca manidipine	89-106	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
20347984-5	2010	In these cells TNF-alpha increased by about 4 times the secretion of IL-8 and Manidipine 5 microM reduced the amount of IL-8 in the culture media by about 40%.	manidipine	78-88	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
21221176-10	2010	The in-vitro experiment I resulted for NaF in 251.7+-22.4 microg/g fluoride and for amine fluoride in 171.7+-14.4 microg/g.	Fluorides	67-75	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
21221176-11	2010	CONCLUSIONS: Fluoride bioavailability of saliva after exposure to NaF was higher compared to amine fluoride.	Fluorides	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	66-69
20649610-7	2010	Moreover, iloprost dose dependently inhibited the secretion of TNF-alpha, IL-6, IL-8 and IL-12p70 in mDCs, while it enhanced IL-10 production.	Iloprost	10-18	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
23662086-0	2010	Remineralization of eroded enamel by a NaF rinse containing a novel calcium phosphate agent in an in situ model: a pilot study.	calcium phosphate	68-85	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
20707554-1	2010	Molecular dynamics simulations are carried out to study the interfacial profiles of alkali metal fluoride solutions (NaF, KF, RbF, and CsF) at 1 atm and 300 K. For these solutions, we find that the occupancy of the cations in the interfacial region is comparable to or greater than that of the F(-) anion.	metal fluoride	91-105	C-X-C motif chemokine ligand 8	Homo sapiens	117-120
20711426-12	2010	CONCLUSIONS/SIGNIFICANCE: The results clearly demonstrate that damage to the bronchial epithelia by poly-L-arginine stimulates polarized IL-6 and IL-8 secretion.	polyarginine	100-115	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
20711431-5	2010	We found that purified HCP and a recombinant HcpA protein induced significant release of IL-8 and TNF-alpha, from cultured polarized intestinal cells (T84 and HT-29 cells) and non-intestinal HeLa cells.	hcp	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
20711431-6	2010	Levels of proinflammatory IL-8 and TNF-alpha, but not IL-2, IL6, or IL-10 cytokines, were increased in the presence of HCP and recombinant HcpA after 6 h of incubation with &gt;or=50 ng/ml of protein, suggesting that stimulation of IL-8 and TNF-alpha are dose and time-dependent.	hcp	119-122	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
20711431-6	2010	Levels of proinflammatory IL-8 and TNF-alpha, but not IL-2, IL6, or IL-10 cytokines, were increased in the presence of HCP and recombinant HcpA after 6 h of incubation with &gt;or=50 ng/ml of protein, suggesting that stimulation of IL-8 and TNF-alpha are dose and time-dependent.	hcp	119-122	C-X-C motif chemokine ligand 8	Homo sapiens	232-236
20505677-4	2010	We found that losartan significantly attenuated the LPS-induced expression of proinflammatory genes TNF-alpha, IL-8 and COX-2.	Losartan	14-22	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
19633914-4	2010	The effect of NaCl, Na2SO4, NaF, NaBr, Na3PO4, and other interfering salts on the sorption of metal ions (50 microg L(-1)) was reported.	Metals	94-99	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
20815772-2	2010	When HNSCC cells were cultured in the presence of ROS, the expression of BRAK was significantly decreased whereas that of IL-8 was increased.	Reactive Oxygen Species	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
20815772-4	2010	The effects of ROS on both BRAK and IL-8 expression were attenuated by pre-treatment with N-acetyl-L-cysteine (NAC), epidermal growth factor receptor (EGFR), and mitogen-activated protein kinase (MAPK) inhibitors.	Reactive Oxygen Species	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
20815772-4	2010	The effects of ROS on both BRAK and IL-8 expression were attenuated by pre-treatment with N-acetyl-L-cysteine (NAC), epidermal growth factor receptor (EGFR), and mitogen-activated protein kinase (MAPK) inhibitors.	Acetylcysteine	90-109	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
20505677-7	2010	Peroxisome proliferator-activated receptor-gamma (PPARgamma) antagonists, GW9662 and T0070907, reversed the inhibitory effects of losartan on LPS-induced TNF-alpha and IL-8 expression in THP-1 macrophages.	2-chloro-5-nitrobenzanilide	74-80	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
20505677-7	2010	Peroxisome proliferator-activated receptor-gamma (PPARgamma) antagonists, GW9662 and T0070907, reversed the inhibitory effects of losartan on LPS-induced TNF-alpha and IL-8 expression in THP-1 macrophages.	Losartan	130-138	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
20412422-7	2010	Scavenger receptor inhibitors, fucoidan and dextran sulfate, inhibited the OxLDL-induced IL-8 and PGE(2) production in the presence of IL-1 beta.	fucoidan	31-39	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
20438865-5	2010	At the same time, muropeptide-stimulated DCs abundantly produced inflammatory chemokines IL-8, MIP-1 alpha and MIP-1 beta, as well as displayed signs of phenotypic and functional maturation.	muropeptide	18-29	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
20515921-3	2010	In the present study, we investigated ATP release from uroepithelial cells infected with bacteria and the effect of ATP on the host cell proinflammatory interleukin 8 (IL-8) response.	Adenosine Triphosphate	116-119	C-X-C motif chemokine ligand 8	Homo sapiens	153-166
20515921-3	2010	In the present study, we investigated ATP release from uroepithelial cells infected with bacteria and the effect of ATP on the host cell proinflammatory interleukin 8 (IL-8) response.	Adenosine Triphosphate	116-119	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
20515921-7	2010	ATP-gamma-S (10 and 100 microM) stimulated release of IL-8 from UROtsa and A498 cells after 6 and 24 h. Experiments with different purinoceptor agonists suggested that P2Y receptors, and not P2X receptors, were responsible for the ATP-gamma-S-induced IL-8 release.	adenosine 5'-O-(3-thiotriphosphate)	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
20515921-7	2010	ATP-gamma-S (10 and 100 microM) stimulated release of IL-8 from UROtsa and A498 cells after 6 and 24 h. Experiments with different purinoceptor agonists suggested that P2Y receptors, and not P2X receptors, were responsible for the ATP-gamma-S-induced IL-8 release.	adenosine 5'-O-(3-thiotriphosphate)	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	251-255
20515921-10	2010	The present study suggests that enhanced ATP release and P2Y receptor activation during urinary tract infection may represent a novel, non-TLR4-mediated mechanism for production of proinflammatory IL-8 in human urinary tract epithelial cells.	Adenosine Triphosphate	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
20412422-7	2010	Scavenger receptor inhibitors, fucoidan and dextran sulfate, inhibited the OxLDL-induced IL-8 and PGE(2) production in the presence of IL-1 beta.	Dextran Sulfate	44-59	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
20412422-8	2010	The p(38) MAPK inhibitors SB203580 and SB202190 and the ERK inhibitor PD98059 inhibited the OxLDL-induced IL-8 production.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	70-77	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
20412422-9	2010	Among oxidized lipids and chemically modified LDL, 7-ketocholesterol enhanced IL-8 production.	7-ketocholesterol	51-68	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
20307681-4	2010	Formoterol enhanced and budesonide inhibited IL-6, CXCL8 and CXCL1 release from LPS-stimulated neutrophils.	Budesonide	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	51-56
20112302-7	2010	IL-8 messenger RNA expression and IL-8 production in the epithelial cells increased following the hemin treatment, but the production was inhibited by ZnPP and catalase.	zinc protoporphyrin	151-155	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
20434478-8	2010	Treatment with ZnO (5mug/cm(2) corresponding to 11.5mug/ml) for 24h induced on LoVo cells a significant decrease of cell viability, H2O2/OH increase, O2(-) and GSH decrease, depolarization of inner mitochondrial membranes, apoptosis and IL-8 release.	Zinc Oxide	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	237-241
20578705-8	2010	Incubation of ARPE-19 cells with 33 mM glucose for 9 days significantly induced the accumulation of VEGF, IL-6, IL-8, TGF-beta, and COX-2, activation of PKCbeta, and reduction of Cx43 and GJIC.	Glucose	39-46	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
20578705-9	2010	Incubation of ARPE-19 cells with 33 mM glucose in the presence of 0-10 microM trans-resveratrol dose-dependently inhibited VEGF, TGF-beta1, COX-2, IL-6, and IL-8 accumulation, PKCbeta activation, and Cx43 degradation and enhanced GJIC.	Glucose	39-46	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
20578705-9	2010	Incubation of ARPE-19 cells with 33 mM glucose in the presence of 0-10 microM trans-resveratrol dose-dependently inhibited VEGF, TGF-beta1, COX-2, IL-6, and IL-8 accumulation, PKCbeta activation, and Cx43 degradation and enhanced GJIC.	Resveratrol	78-95	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
20510674-0	2010	Thromboxane A(2) increases endothelial permeability through upregulation of interleukin-8.	thromboxane a	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	76-89
20626862-0	2010	Pneumocystis cell wall beta-glucan stimulates calcium-dependent signaling of IL-8 secretion by human airway epithelial cells.	beta-Glucans	23-34	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
20626862-0	2010	Pneumocystis cell wall beta-glucan stimulates calcium-dependent signaling of IL-8 secretion by human airway epithelial cells.	Calcium	46-53	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
20626862-3	2010	Several previous studies indicate that airway epithelial cells release the neutrophil chemoattractant proteins, MIP-2 (rodents) and IL-8 (humans), in response to Pneumocystis and purified Pneumocystis cell wall beta-glucans (PCBG) through the NF-kappaB-dependent pathway.	beta-Glucans	211-223	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
20626862-3	2010	Several previous studies indicate that airway epithelial cells release the neutrophil chemoattractant proteins, MIP-2 (rodents) and IL-8 (humans), in response to Pneumocystis and purified Pneumocystis cell wall beta-glucans (PCBG) through the NF-kappaB-dependent pathway.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	225-229	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
20626862-4	2010	However, little is known about the molecular mechanisms that are involved in the activation of airway epithelium cells by PCBG resulting in the secretion of IL-8.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	122-126	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
20626862-6	2010	RESULTS: Our data provide evidence that PCBG induces phosphorylation of the MAPKs, ERK, and p38, the activation of NF-kappaB and the subsequently secretion of IL-8 in a calcium-dependent manner.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
20626862-6	2010	RESULTS: Our data provide evidence that PCBG induces phosphorylation of the MAPKs, ERK, and p38, the activation of NF-kappaB and the subsequently secretion of IL-8 in a calcium-dependent manner.	Calcium	169-176	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
20626862-8	2010	Preincubation of the cells with D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) a potent inhibitor of the glycosphingolipids synthesis, prior to PCBG stimulation, significantly decreased IL-8 production.	RV 538	32-88	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
20626862-8	2010	Preincubation of the cells with D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) a potent inhibitor of the glycosphingolipids synthesis, prior to PCBG stimulation, significantly decreased IL-8 production.	RV 538	90-94	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
20626862-9	2010	CONCLUSION: These data indicate that PCBG activates calcium dependent MAPK signaling resulting in the release of IL-8 in a process that requires glycosphingolipid for optimal signaling.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
20626862-9	2010	CONCLUSION: These data indicate that PCBG activates calcium dependent MAPK signaling resulting in the release of IL-8 in a process that requires glycosphingolipid for optimal signaling.	Calcium	52-59	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
20626862-9	2010	CONCLUSION: These data indicate that PCBG activates calcium dependent MAPK signaling resulting in the release of IL-8 in a process that requires glycosphingolipid for optimal signaling.	Glycosphingolipids	145-162	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
20504277-5	2010	RESULTS: Treatment of cultured endothelial cells with sodium fluoride (NaF) results in a rapid and potent stimulation of podosome formation.	Sodium Fluoride	54-69	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
20508179-12	2010	The inhibitory effect of Dll4 on interleukin-8 was abolished by DAPT, a Notch inhibitor, or by coculturing activated human monocytes with Ad-sDll4-infected endothelial cells.	dapt	64-68	C-X-C motif chemokine ligand 8	Homo sapiens	33-46
20663736-4	2010	With the advent of hybrid positron emission tomography (PET)/CT scanners there has been an increasing interest in using various PET tracers to evaluate skeletal disease including [(18)F]fluoride (NaF) as a bone-specific tracer and [(18)F]fluorodeoxyglucose and [(18)F]choline as tumour-specific tracers.	Fluorides	186-194	C-X-C motif chemokine ligand 8	Homo sapiens	196-199
20663736-4	2010	With the advent of hybrid positron emission tomography (PET)/CT scanners there has been an increasing interest in using various PET tracers to evaluate skeletal disease including [(18)F]fluoride (NaF) as a bone-specific tracer and [(18)F]fluorodeoxyglucose and [(18)F]choline as tumour-specific tracers.	Fluorodeoxyglucose F18	238-256	C-X-C motif chemokine ligand 8	Homo sapiens	196-199
20663736-4	2010	With the advent of hybrid positron emission tomography (PET)/CT scanners there has been an increasing interest in using various PET tracers to evaluate skeletal disease including [(18)F]fluoride (NaF) as a bone-specific tracer and [(18)F]fluorodeoxyglucose and [(18)F]choline as tumour-specific tracers.	Choline	268-275	C-X-C motif chemokine ligand 8	Homo sapiens	196-199
20434448-0	2010	Rho-kinase mediates lysophosphatidic acid-induced IL-8 and MCP-1 production via p38 and JNK pathways in human endothelial cells.	lysophosphatidic acid	20-41	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
20510674-7	2010	Overall, these results suggest that U46619 promotes vascular permeability through the production of IL-8 via NF-kappaB activation in endothelial cells.	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid	36-42	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
20194077-0	2010	Phosphorylation of p65 is required for zinc oxide nanoparticle-induced interleukin 8 expression in human bronchial epithelial cells.	Zinc Oxide	39-49	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
20463039-10	2010	Furthermore, resveratrol down-regulated the expression and secretion of interleukin-6 and interleukin-8.	Resveratrol	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	90-103
20194077-11	2010	Moreover, ZnO exposure also increased the binding of p65 to the IL-8 promoter and p65 phosphorylation at serines 276 and 536.	Zinc Oxide	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
20378727-0	2010	17Beta-estradiol inhibits IL-8 in cystic fibrosis by up-regulating secretory leucoprotease inhibitor.	Estradiol	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
20185130-5	2010	We found that 5"-NIO inhibited TNF-alpha induced MCP-1 and IL-8 expression at the RNA and protein levels in HUVECs.	5'-nitroindirubinoxime	14-20	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
20185130-6	2010	Specifically, 5"-NIO significantly inhibited the TNF-alpha stimulated release of MCP-1 and IL-8, with levels that were only 19.8% and 30.9% of those of untreated control cells, respectively.	5'-nitroindirubinoxime	14-20	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
20206688-2	2010	The NF-kappaB-dependent gene expression of IL8, IL6, PTGS2/COX2, TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 (PGE2) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB-dependent gene expression in bystander cells.	Dinoprostone	151-167	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
20206688-2	2010	The NF-kappaB-dependent gene expression of IL8, IL6, PTGS2/COX2, TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 (PGE2) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB-dependent gene expression in bystander cells.	Dinoprostone	169-173	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
20206688-3	2010	As a result, bystander cells also started expression and production of interleukin-8, interleukin-6, COX-2-generated PGE2 and interleukin-33 (IL-33) followed by autocrine/paracrine stimulation of the NF-kappaB and MAPK pathways.	Dinoprostone	117-121	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
20194077-12	2010	Overexpression of p65 constructs mutated at serines 276 or 536 significantly reduced ZnO-induced increase in IL-8 promoter reporter activity.	Serine	44-51	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
20194077-12	2010	Overexpression of p65 constructs mutated at serines 276 or 536 significantly reduced ZnO-induced increase in IL-8 promoter reporter activity.	Zinc Oxide	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
20194077-13	2010	CONCLUSION: p65 phosphorylation and IkappaBalpha phosphorylation and degradation are the primary mechanisms involved in ZnO nanoparticle-induced IL-8 expression in human bronchial epithelial cells.	Zinc Oxide	120-123	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
20194077-1	2010	BACKGROUND: Exposure to zinc oxide (ZnO) in environmental and occupational settings causes acute pulmonary responses through the induction of proinflammatory mediators such as interleukin-8 (IL-8).	Zinc Oxide	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	176-189
20194077-1	2010	BACKGROUND: Exposure to zinc oxide (ZnO) in environmental and occupational settings causes acute pulmonary responses through the induction of proinflammatory mediators such as interleukin-8 (IL-8).	Zinc Oxide	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
20194077-1	2010	BACKGROUND: Exposure to zinc oxide (ZnO) in environmental and occupational settings causes acute pulmonary responses through the induction of proinflammatory mediators such as interleukin-8 (IL-8).	Zinc Oxide	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	176-189
20194077-1	2010	BACKGROUND: Exposure to zinc oxide (ZnO) in environmental and occupational settings causes acute pulmonary responses through the induction of proinflammatory mediators such as interleukin-8 (IL-8).	Zinc Oxide	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
20194077-2	2010	OBJECTIVE: We investigated the effect of ZnO nanoparticles on IL-8 expression and the underlying mechanisms in human bronchial epithelial cells.	Zinc Oxide	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
20194077-4	2010	Transcriptional activity of IL-8 promoter and nuclear factor kappa B (NFkappaB) in ZnO-treated BEAS-2B cells was measured using transient gene transfection of the luciferase reporter construct with or without p65 constructs.	Zinc Oxide	83-86	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
20194077-7	2010	RESULTS: ZnO exposure (2-8 microg/mL) increased IL-8 mRNA and protein expression.	Zinc Oxide	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
20194077-8	2010	Inhibition of transcription with actinomycin D blocked ZnO-induced IL-8 expression, which was consistent with the observation that ZnO exposure increased IL-8 promoter reporter activity.	Dactinomycin	33-46	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
20194077-8	2010	Inhibition of transcription with actinomycin D blocked ZnO-induced IL-8 expression, which was consistent with the observation that ZnO exposure increased IL-8 promoter reporter activity.	Dactinomycin	33-46	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
20194077-8	2010	Inhibition of transcription with actinomycin D blocked ZnO-induced IL-8 expression, which was consistent with the observation that ZnO exposure increased IL-8 promoter reporter activity.	Zinc Oxide	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
20194077-8	2010	Inhibition of transcription with actinomycin D blocked ZnO-induced IL-8 expression, which was consistent with the observation that ZnO exposure increased IL-8 promoter reporter activity.	Zinc Oxide	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
20194077-8	2010	Inhibition of transcription with actinomycin D blocked ZnO-induced IL-8 expression, which was consistent with the observation that ZnO exposure increased IL-8 promoter reporter activity.	Zinc Oxide	131-134	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
19926732-6	2010	Formoterol and salmeterol inhibited LPS-stimulated release of TNF-alpha (mean effective concentration (EC(50)) 2.4+/-1.8 and 3.5+/-2.7 nM, respectively; n = 11-16), GM-CSF (EC(50) 24.6+/-2.1 and 52.4+/-40.8 nM, respectively, n = 11-12) but not CXCL8 from LPS-stimulated MDM.	Formoterol Fumarate	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	244-249
20194077-8	2010	Inhibition of transcription with actinomycin D blocked ZnO-induced IL-8 expression, which was consistent with the observation that ZnO exposure increased IL-8 promoter reporter activity.	Zinc Oxide	131-134	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
19926732-6	2010	Formoterol and salmeterol inhibited LPS-stimulated release of TNF-alpha (mean effective concentration (EC(50)) 2.4+/-1.8 and 3.5+/-2.7 nM, respectively; n = 11-16), GM-CSF (EC(50) 24.6+/-2.1 and 52.4+/-40.8 nM, respectively, n = 11-12) but not CXCL8 from LPS-stimulated MDM.	Salmeterol Xinafoate	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	244-249
20194077-9	2010	Further study demonstrated that the kappaB-binding site in the IL-8 promoter was required for ZnO-induced IL-8 transcriptional activation.	Zinc Oxide	94-97	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
19926732-7	2010	Budesonide inhibited release of all three cytokines (EC(50) TNF-alpha: 1.2+/-0.4 nM; GM-CSF: 0.4+/-0.2 nM; CXCL8: 0.4+/-0.1 nM; n = 3-4).	Budesonide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	107-112
20194077-9	2010	Further study demonstrated that the kappaB-binding site in the IL-8 promoter was required for ZnO-induced IL-8 transcriptional activation.	Zinc Oxide	94-97	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
20479083-5	2010	The recombinant SSL5-Sepharose also bound to proMMP-9 secreted by interleukin 8 (IL-8)-stimulated neutrophils and HT1080 fibrosarcoma cells.	Sepharose	21-30	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
20334899-3	2010	In HCT 116 and HCT-8 colorectal adenocarcinoma cells, the production of IL-8 immunoreactivity was up-regulated by IL-1beta, tumor necrosis factor (TNF)-alpha, the toll-like receptor (TLR) ligands double-stranded RNA and peptidoglycan and phorbol ester.	Phorbol Esters	238-251	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
20557833-8	2010	The addition of linezolid significantly reduced mRNA levels of IL-1beta, IL-6, IL-8 and TNF-alpha; (p &lt; 0.05) after 2 and 4 h. LPS stimulation also increased levels of IL-6, IL-8 and TNF-alpha between 100 and 1000-fold.	Linezolid	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
20479083-5	2010	The recombinant SSL5-Sepharose also bound to proMMP-9 secreted by interleukin 8 (IL-8)-stimulated neutrophils and HT1080 fibrosarcoma cells.	Sepharose	21-30	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
20416374-9	2010	This is approached through a few illustrative examples, including the interaction of HS and heparin-derived species with the chemokine IL-8, the growth factors FGF1 and FGF2, and the modulation of the activity of the enzyme heparanase by these species.	Heparin	92-99	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
20819396-7	2010	Methotrexate given prior to the day 2 abrasions reduced neutrophil extravasation and IL8 levels compared with those on day 1.	Methotrexate	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
20819396-8	2010	rC5a partially abrogated the methotrexate-induced reduction in neutrophil extravasation and IL8 production.	Methotrexate	29-41	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
21128470-1	2010	Highly ordered nanotube oxide layers were developed on low rigidity quaternary beta-type Ti-35Nb-5Ta-7Zr alloy by controlled anodic oxidation in electrolyte containing 1 M H3PO4 and 0.5 wt% NaF at room temperature.	Oxides	24-29	C-X-C motif chemokine ligand 8	Homo sapiens	190-193
20557833-8	2010	The addition of linezolid significantly reduced mRNA levels of IL-1beta, IL-6, IL-8 and TNF-alpha; (p &lt; 0.05) after 2 and 4 h. LPS stimulation also increased levels of IL-6, IL-8 and TNF-alpha between 100 and 1000-fold.	Linezolid	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
20483454-3	2010	Interleukin (IL) 8 has been implicated as a regulator of EVT invasion.	EVT	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	0-18
20618689-10	2010	The modest upregulation of IL-8 and IL-6 might be associated with the milder clinical manifestations of PCP in AIDS patients.	pcp	104-107	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
20389259-1	2010	BACKGROUND: The aim of this prospective study is to evaluate the diagnostic and prognostic usefulness of F-18 sodium fluoride (NaF) positron emission tomography-computed tomography (PET-CT) relative to Tc-99m methylene diphosphonate (MDP) planar bone scintigraphy with no CT (BS) for hepatocellular carcinoma (HCC) patients with suspicious bone metastasis.	Fluorine-18	105-109	C-X-C motif chemokine ligand 8	Homo sapiens	127-130
20389259-1	2010	BACKGROUND: The aim of this prospective study is to evaluate the diagnostic and prognostic usefulness of F-18 sodium fluoride (NaF) positron emission tomography-computed tomography (PET-CT) relative to Tc-99m methylene diphosphonate (MDP) planar bone scintigraphy with no CT (BS) for hepatocellular carcinoma (HCC) patients with suspicious bone metastasis.	Sodium Fluoride	110-125	C-X-C motif chemokine ligand 8	Homo sapiens	127-130
20389259-1	2010	BACKGROUND: The aim of this prospective study is to evaluate the diagnostic and prognostic usefulness of F-18 sodium fluoride (NaF) positron emission tomography-computed tomography (PET-CT) relative to Tc-99m methylene diphosphonate (MDP) planar bone scintigraphy with no CT (BS) for hepatocellular carcinoma (HCC) patients with suspicious bone metastasis.	Technetium Tc 99m Medronate	202-232	C-X-C motif chemokine ligand 8	Homo sapiens	127-130
20389259-1	2010	BACKGROUND: The aim of this prospective study is to evaluate the diagnostic and prognostic usefulness of F-18 sodium fluoride (NaF) positron emission tomography-computed tomography (PET-CT) relative to Tc-99m methylene diphosphonate (MDP) planar bone scintigraphy with no CT (BS) for hepatocellular carcinoma (HCC) patients with suspicious bone metastasis.	methylene diphosphonate	234-237	C-X-C motif chemokine ligand 8	Homo sapiens	127-130
20483454-4	2010	HYPOTHESIS: uNK cell stimulation of EVT invasion is associated with IL-8 levels.	EVT	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
20483454-12	2010	Exogenous IL-8 stimulated EVT invasion in a paracrine manner.	EVT	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
20483454-16	2010	CONCLUSION: uNK cell stimulation of EVT invasion is partially mediated by IL-8.	EVT	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
20591071-12	2010	Through ERK inhibitor (U0126) and NF-kB inhibitor (caffeine acid phenethyl ester) treatment, it was proven that ERK and NF-kB regulated chitinase-induced IL-8 expression.	U 0126	23-28	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
19777241-6	2010	PGE(2) and IL-8 secretion was also induced by IL-1beta stimulation and significantly suppressed by EGCG.	epigallocatechin gallate	99-103	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
19777241-8	2010	EGCG may inhibit the expression of inflammatory mediators, such as COX-2, PGE(2), and IL-8, induced by IL-1beta in human synovial fibroblasts.	epigallocatechin gallate	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
19777241-0	2010	Effects of (-)-epigallocatechin-3-gallate on cyclooxygenase 2, PGE(2), and IL-8 expression induced by IL-1beta in human synovial fibroblasts.	epigallocatechin gallate	11-41	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
20591071-12	2010	Through ERK inhibitor (U0126) and NF-kB inhibitor (caffeine acid phenethyl ester) treatment, it was proven that ERK and NF-kB regulated chitinase-induced IL-8 expression.	caffeine acid phenethyl ester	51-80	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
20417223-5	2010	Data show that thimerosal and mercury derivatives induced DC activation, as monitored by CD86 and HLA-DR overexpression associated with the secretion of tumor necrosis factor alpha and interleukin 8, similarly to lipopolysaccharide and the sensitizers, 1-chloro-2,4-dinitrobenzene (DNCB) and nickel sulfate, which were used as positive controls.	Thimerosal	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	185-198
20214469-5	2010	Additionally, 3D integrin engagement by RGD-modified alginate matrices increased IL-8 secretion independently of oxygen, whereas VEGF secretion was only moderately affected by cell-extracellular matrix interactions.	Alginates	53-61	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
20417223-5	2010	Data show that thimerosal and mercury derivatives induced DC activation, as monitored by CD86 and HLA-DR overexpression associated with the secretion of tumor necrosis factor alpha and interleukin 8, similarly to lipopolysaccharide and the sensitizers, 1-chloro-2,4-dinitrobenzene (DNCB) and nickel sulfate, which were used as positive controls.	Mercury	30-37	C-X-C motif chemokine ligand 8	Homo sapiens	185-198
20457211-4	2010	Thimerosal and mercury derivatives induced in U937 an overexpression of CD86 and interleukin (IL)-8 secretion similarly to 1-chloro-2,4-dinitrobenzene (DNCB), a sensitizer used as a positive control for DC activation.	Thimerosal	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	81-99
20457211-4	2010	Thimerosal and mercury derivatives induced in U937 an overexpression of CD86 and interleukin (IL)-8 secretion similarly to 1-chloro-2,4-dinitrobenzene (DNCB), a sensitizer used as a positive control for DC activation.	Mercury	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	81-99
21055061-10	2010	Corresponding expression of NF-kappaB, IL-1beta, IL-8 and COX-2 decreased after the addition of Wedelolactone (relative values were 0.917 +- 0.188, 0.180 +- 0.008, 0, 0 respectively).	wedelolactone	96-109	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
20731040-6	2010	FSEM showed that pure titanium and Ti-Ni-Cr alloy surface corrosion, pure titanium in the artificial saliva containing 0.2% NaF was most serious.	Titanium	74-82	C-X-C motif chemokine ligand 8	Homo sapiens	124-127
20531411-8	2010	Metronomic gemcitabine also significantly increased apoptosis in cancer-associated fibroblasts and induced greater reductions in the tumour levels of multiple pro-angiogenic factors, including EGF, IL-1alpha, IL-8, ICAM-1, and VCAM-1.	gemcitabine	11-22	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
20206138-5	2010	In human HaCaT keratinocytes falcarinol increased the expression of the pro-allergic chemokines IL-8 and CCL2/MCP-1 in a CB(1) receptor-dependent manner.	falcarinol	29-39	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
22911911-11	2010	CONCLUSION: The levels of serum pro-inflammatory cytokines IL-8 &amp; TNF- alpha were significantly associated with subjects having respiratory symptoms &amp; further supporting that they are inflammatory markers in respiratory symptoms.	Adenosine Monophosphate	65-68	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
22911911-11	2010	CONCLUSION: The levels of serum pro-inflammatory cytokines IL-8 &amp; TNF- alpha were significantly associated with subjects having respiratory symptoms &amp; further supporting that they are inflammatory markers in respiratory symptoms.	Adenosine Monophosphate	154-157	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
20206208-11	2010	Measurements of stimulated cytokine production demonstrated (i) that cumulative hypoxia stimulates especially the secretion of IL-1beta, IL-10 and IL-8, and (ii) that lack of glucose results in lower cytokine concentrations.	Glucose	175-182	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
20354173-7	2010	The increase in IL-8 release occurred despite reduced IL-8 mRNA levels in the donor granulocytes after in vivo G-CSF/dexa treatment, indicating that the enhanced TLR-induced IL-8 production was largely determined by posttranscriptional regulation.	Dexamethasone	117-121	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
20441516-3	2010	Albendazole treatment, compared with placebo, was associated with significantly decreased plasma interleukin (IL) 10 levels (P = .01)ot associated with significant changes in levels of IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-12p70, IL-13, interferon gamma, tumor necrosis factor alpha, or thymic stromal lymphopoietin.	Albendazole	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	225-229
20307528-5	2010	The RT-PCR, real-time PCR, and ELISA analyses demonstrated that LPS-induced mRNAs encoding IL-6 and IL-8 and the subsequent secretion of IL-6 and IL-8 were inhibited by glucosamine treatment.	Glucosamine	169-180	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
20307528-5	2010	The RT-PCR, real-time PCR, and ELISA analyses demonstrated that LPS-induced mRNAs encoding IL-6 and IL-8 and the subsequent secretion of IL-6 and IL-8 were inhibited by glucosamine treatment.	Glucosamine	169-180	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
20530802-2	2010	We found that neutrophils released cellular adenosine triphosphate (ATP) in response to exogenous stimuli such as formylated bacterial peptides and inflammatory mediators that activated Fcgamma, interleukin-8, C5a complement, and leukotriene B(4) receptors.	Adenosine Triphosphate	44-66	C-X-C motif chemokine ligand 8	Homo sapiens	195-208
20530802-2	2010	We found that neutrophils released cellular adenosine triphosphate (ATP) in response to exogenous stimuli such as formylated bacterial peptides and inflammatory mediators that activated Fcgamma, interleukin-8, C5a complement, and leukotriene B(4) receptors.	Adenosine Triphosphate	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	195-208
20451499-4	2010	Thrombin activated Akt, PKC and MAPK in HAoSMC, and thrombin-mediated expression of IL-6 and CXCL8 was significantly inhibited by LY294002, AKT IV, RO318220, and GF109203X as well as by diphenyleneiodium at the messenger RNA and the protein levels.	bisindolylmaleimide I	162-171	C-X-C motif chemokine ligand 8	Homo sapiens	93-98
20451499-4	2010	Thrombin activated Akt, PKC and MAPK in HAoSMC, and thrombin-mediated expression of IL-6 and CXCL8 was significantly inhibited by LY294002, AKT IV, RO318220, and GF109203X as well as by diphenyleneiodium at the messenger RNA and the protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	C-X-C motif chemokine ligand 8	Homo sapiens	93-98
20451499-4	2010	Thrombin activated Akt, PKC and MAPK in HAoSMC, and thrombin-mediated expression of IL-6 and CXCL8 was significantly inhibited by LY294002, AKT IV, RO318220, and GF109203X as well as by diphenyleneiodium at the messenger RNA and the protein levels.	Ro 31-8220	148-156	C-X-C motif chemokine ligand 8	Homo sapiens	93-98
20371264-6	2010	Exposure of MWCNT (10-100mug/ml) to HEK cells resulted in concentration dependent cell membrane damage (as indicated by the increased levels of LDH), increased production of IL-8, increased TBARS and decreased intracellular glutathione levels.	mwcnt	12-17	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
20451499-4	2010	Thrombin activated Akt, PKC and MAPK in HAoSMC, and thrombin-mediated expression of IL-6 and CXCL8 was significantly inhibited by LY294002, AKT IV, RO318220, and GF109203X as well as by diphenyleneiodium at the messenger RNA and the protein levels.	diphenyleneiodium	186-203	C-X-C motif chemokine ligand 8	Homo sapiens	93-98
20451499-5	2010	SB202129 and U0126 also significantly attenuated thrombin-mediated release of IL-6 and CXCL8 proteins from HAoSMC.	U 0126	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	87-92
20092409-3	2010	We further observed that supplementation with H(2)S or an endogenous precursor of H(2)S (l-cysteine) in culture medium prevents IL-8 and MCP-1 secretion in high-glucose-treated human U937 monocytes.	Hydrogen Sulfide	46-51	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
19930229-0	2010	Matrix metalloproteinases, IL-8 and glutathione in the prognosis of workers exposed to chlorine.	Chlorine	87-95	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
20568377-6	2010	After treatment, forced expiratory volume in 1 second significantly increased and sputum eosinophil percentages and IL-5 and IL-8 concentrations significantly decreased in the prednisone group, whereas no changes were observed in the placebo group.	Prednisone	176-186	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
20568377-7	2010	The positive effect of prednisone treatment was observed only in patients with baseline sputum eosinophilia, whereas in noneosinophilic patients with severe asthma prednisone induced only a significant decrease of sputum IL-8.	Prednisone	164-174	C-X-C motif chemokine ligand 8	Homo sapiens	221-225
20035908-0	2010	The effect of Na(2)CO(3), NaF and NH(4)OH on the stability and release behavior of sol-gel derived silica xerogels embedded with bioactive compounds.	silica xerogels	99-114	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
19597128-4	2010	The effect of hydrogen peroxide (H(2)O(2)) on the release of IL-8 from BEAS-2B cells and primary human bronchial epithelial cells after stimulation with polyinosine-polycytidylic acid [poly(I:C)], a synthetic analog of viral dsRNA and a ligand for TLR3, and the signal transduction were examined.	Hydrogen Peroxide	14-31	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
19597128-4	2010	The effect of hydrogen peroxide (H(2)O(2)) on the release of IL-8 from BEAS-2B cells and primary human bronchial epithelial cells after stimulation with polyinosine-polycytidylic acid [poly(I:C)], a synthetic analog of viral dsRNA and a ligand for TLR3, and the signal transduction were examined.	polyinosine-polycytidylic acid	153-183	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
19597128-5	2010	One hundred to 150 muM H(2)O(2) significantly potentiated the release of IL-8 from the epithelial cells after stimulation with 10 microg/ml poly(I:C).	Hydrogen Peroxide	23-31	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
19597128-5	2010	One hundred to 150 muM H(2)O(2) significantly potentiated the release of IL-8 from the epithelial cells after stimulation with 10 microg/ml poly(I:C).	poly	140-144	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
19597128-6	2010	The H(2)O(2)-augmented IL-8 release was inhibited by treatment with N-acetylcysteine.	Acetylcysteine	68-84	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
20517377-1	2010	Sodium was incorporated into Cu(In,Ga)Se(2) (CIGS) thin films by evaporating NaF before the second and third stages and after the third stage of CIGS deposition.	Sodium	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
20092409-3	2010	We further observed that supplementation with H(2)S or an endogenous precursor of H(2)S (l-cysteine) in culture medium prevents IL-8 and MCP-1 secretion in high-glucose-treated human U937 monocytes.	Hydrogen Sulfide	82-87	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
20092409-3	2010	We further observed that supplementation with H(2)S or an endogenous precursor of H(2)S (l-cysteine) in culture medium prevents IL-8 and MCP-1 secretion in high-glucose-treated human U937 monocytes.	Cysteine	89-99	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
20304034-0	2010	Galactose specific adhesin of enteroaggregative E. coli induces IL-8 secretion via activation of MAPK and STAT-3 in INT-407 cells.	Galactose	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
20188144-0	2010	Selenium supplementation attenuates procollagen-1 and interleukin-8 production in fat-loaded human C3A hepatoblastoma cells treated with TGFbeta1.	Selenium	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
20188144-9	2010	CONCLUSIONS: Our data establish that both fat-loading and suboptimal selenium status enhance collagen and IL-8 production by C3A hepatocytes in response to TGFbeta1, possibly as part of an epithelial to mesenchymal transition.	Selenium	69-77	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
20607488-3	2010	This study showed that ethanol extract of AJK interestingly suppressed the production and mRNA expression of TNF-alpha, IL-6 and IL-8, as important inflammatory cytokines.	Ethanol	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
20304034-10	2010	Further, the adhesin induced IL-8 secretion was reduced in the presence of the inhibitors of MEK (PD098059), p38-MAPK (SB203580) and JAK (-2,-3)/STAT-3 pathway (AG490).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	98-106	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
20053132-5	2010	Copper stimulated cell proliferation and the expression of MMP-1 and IL-8 genes at the protein, mRNA, and promoter levels, indicating transcriptional regulation, without significantly altering TIMP-1.	Copper	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
20304034-10	2010	Further, the adhesin induced IL-8 secretion was reduced in the presence of the inhibitors of MEK (PD098059), p38-MAPK (SB203580) and JAK (-2,-3)/STAT-3 pathway (AG490).	SB 203580	119-127	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
20304034-11	2010	CONCLUSIONS: We propose that STAT-3 activation is quintessential for the galactose specific adhesin induced IL-8 secretion by INT-407 cells and must occur in concert with the activation of ERK1/2.	Galactose	73-82	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
20053132-2	2010	Wound healing and skin aging are facilitated by matrixmetalloproteinases (MMP), which remodel the extracellular matrix, and interleukin-8 (IL-8), linked with copper.	Copper	158-164	C-X-C motif chemokine ligand 8	Homo sapiens	124-137
20053132-2	2010	Wound healing and skin aging are facilitated by matrixmetalloproteinases (MMP), which remodel the extracellular matrix, and interleukin-8 (IL-8), linked with copper.	Copper	158-164	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
20053132-3	2010	This research investigated the mechanism to copper"s role in wound healing or skin aging by regulation of MMP-1 and IL-8 genes.	Copper	44-50	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
20445007-7	2010	PAM stimulation also induced IL-1beta, IL-6, and IL-8.	pam	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
20445007-10	2010	In contrast, delayed DEX addition significantly suppressed PAM-induced IL-1beta, IL-6, or IL-8 and also suppressed LPS-induced IL-1beta and IL-8.	Dexamethasone	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
20445007-10	2010	In contrast, delayed DEX addition significantly suppressed PAM-induced IL-1beta, IL-6, or IL-8 and also suppressed LPS-induced IL-1beta and IL-8.	Dexamethasone	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
20445007-10	2010	In contrast, delayed DEX addition significantly suppressed PAM-induced IL-1beta, IL-6, or IL-8 and also suppressed LPS-induced IL-1beta and IL-8.	pam	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
20053132-6	2010	The research suggests that copper facilitates wound healing as well as skin aging via the induction of MMP-1 expression, with limiting MMP effect at the higher concentrations through enhanced IL-8 expression, which favors extracellular matrix deposition.	Copper	27-33	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
20232292-8	2010	Ethanol-exposed macrophages developed enhanced interleukin 6 (IL6), IL8, and tumor necrosis factor alpha responses to lipopolysaccharide with time-dependent increases in histone acetylation that could be prevented by inhibition of ethanol metabolism.	Ethanol	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
21119886-6	2010	Here, we provide a view suggesting that caffeine could exert some of its effects by acting on several signaling complexes composed of HIF-1alpha/VEGF/IL-8 along with NO, TNF-alpha, IL1, and GHRH, among others.	Caffeine	40-48	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
20107167-7	2010	RESULTS: Zymosan induced the release of IL-6 and IL-8 from corneal fibroblasts without affecting either the release of IL-1beta, IL-12, IP-10, or RANTES or the expression of ICAM-1 or VCAM-1.	Zymosan	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
20091087-0	2010	Geniposide inhibits interleukin-6 and interleukin-8 production in lipopolysaccharide-induced human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways.	geniposide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	38-51
20091087-1	2010	OBJECTIVE: The aim of this study was to investigate the inhibitory effect of geniposide on lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) and interleukin-8 (IL-8) production in human umbilical vein endothelial cells (HUVECs).	geniposide	77-87	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
20091087-6	2010	RESULTS: Geniposide effectively inhibited LPS-induced expression of IL-6 and IL-8 in HUVECs at the transcription and translation levels.	geniposide	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
20091087-9	2010	CONCLUSION: The results show that geniposide can inhibit LPS-induced IL-6 and IL-8 production in HUVECs by blocking p38 MAPK and ERK1/2 signaling pathways.	geniposide	34-44	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
20635653-4	2010	RESULTS: The corrosion potential (E(corr)) and polarization resistance (R(p)) values of titanium alloy decreased with the increasing of NaF concentration, while the corrosion current density (I(corr)) values increased with the increasing of NaF concentration in acidic artificial saliva.	Titanium	88-102	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
20635653-4	2010	RESULTS: The corrosion potential (E(corr)) and polarization resistance (R(p)) values of titanium alloy decreased with the increasing of NaF concentration, while the corrosion current density (I(corr)) values increased with the increasing of NaF concentration in acidic artificial saliva.	Titanium	88-102	C-X-C motif chemokine ligand 8	Homo sapiens	241-244
20635653-7	2010	CONCLUSION: The fluoride ions have a negative influence on the corrosion resistance of Ti-12Zr alloy and Ti-6Al-4V alloy, especially in the acidic artificial saliva which contained over 0.1% NaF.	Fluorides	16-24	C-X-C motif chemokine ligand 8	Homo sapiens	191-194
20107167-9	2010	The zymosan-induced release of IL-6 and IL-8 was attenuated by inhibitors of ERK, p38, JNK, and NF-kappaB signaling.	Zymosan	4-11	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
20107167-10	2010	CONCLUSIONS: Zymosan induces the release of IL-6 and IL-8 from human corneal fibroblasts in a manner dependent on MAPK and NF-kappaB signaling pathways.	Zymosan	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
20302854-0	2010	Mycophenolic acid inhibits the phosphorylation of NF-kappaB and JNKs and causes a decrease in IL-8 release in H2O2-treated human renal proximal tubular cells.	Mycophenolic Acid	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
20193726-10	2010	CONCLUSIONS: The incorporation of NaF 0.05% fluoride therapy to the cariogenic challenge was capable to recover the original microhardness of dentin at 50 and 100 microm with all the tested materials.	Fluorides	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
19428234-10	2010	Moreover, tryptophan reduced the expression of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin (IL)-6, interferon (IFN)-gamma, IL-12p40, IL-1beta and IL-17, as well as IL-8 and intracellular adhesion molecule-1, and resulted in increased expression of apoptosis initiators caspase-8 and Bax.	Tryptophan	10-20	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
20181660-3	2010	Similar to PKR inhibitors, Hck inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyramidine (PP2) suppressed p38 activation and p38-driven interleukin 8 (IL-8) expression in the U937 human monocyte cell line.	4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyramidine	41-104	C-X-C motif chemokine ligand 8	Homo sapiens	152-165
20181660-3	2010	Similar to PKR inhibitors, Hck inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyramidine (PP2) suppressed p38 activation and p38-driven interleukin 8 (IL-8) expression in the U937 human monocyte cell line.	4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyramidine	41-104	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
19910110-2	2010	Phosphorylation of p65 at serine 276 is required for the expression of a subset of NF-kappaB regulated genes, including vascular cell adhesion molecule-1 (VCAM-1) and interleukin-8 (IL-8).	Serine	26-32	C-X-C motif chemokine ligand 8	Homo sapiens	167-180
19910110-2	2010	Phosphorylation of p65 at serine 276 is required for the expression of a subset of NF-kappaB regulated genes, including vascular cell adhesion molecule-1 (VCAM-1) and interleukin-8 (IL-8).	Serine	26-32	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
20512931-6	2010	In contrast, inhibition of SHP-2 enzymatic activity (sodium stibogluconate) abrogated the increased ERK phosphorylation associated with integrin beta4 silencing in LPS-treated EC and attenuated the increases in levels of IL-6 and IL-8 in integrin-beta4-silenced EC.	Antimony Sodium Gluconate	53-74	C-X-C motif chemokine ligand 8	Homo sapiens	230-234
20494134-4	2010	Induction of IL-8 production by both alpha-lactalbumin and beta-lactoglobulin was higher than that by lactose and NDM; alpha-lactalbumin was a more potent inducer of IL-8 than beta-lactoglobulin and IL-1beta alone in both unstimulated and stimulated cells.	Lactose	102-109	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
20200221-8	2010	Exposure to 4-OPA significantly elevated IL-8, IL-6, GM-CSF, and TNF-alpha while glutaraldehyde caused significant elevations in IL-6, IL-8, and TNF-alpha.	4-oxopentanal	12-17	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
20200221-8	2010	Exposure to 4-OPA significantly elevated IL-8, IL-6, GM-CSF, and TNF-alpha while glutaraldehyde caused significant elevations in IL-6, IL-8, and TNF-alpha.	Glutaral	81-95	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
20200221-9	2010	IL-6 and IL-8 were also significantly elevated after exposure to diacetyl, glyoxal, and methyl glyoxal.	Glyoxal	75-82	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
20200221-9	2010	IL-6 and IL-8 were also significantly elevated after exposure to diacetyl, glyoxal, and methyl glyoxal.	Glyoxal	95-102	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
20302854-0	2010	Mycophenolic acid inhibits the phosphorylation of NF-kappaB and JNKs and causes a decrease in IL-8 release in H2O2-treated human renal proximal tubular cells.	Hydrogen Peroxide	110-114	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
20302854-5	2010	Pre-incubation of the cells with mycophenolic acid (MPA) resulted in reduced phosphorylation of both JNKs and NF-kappaB, and reduced IL-8 release in H(2)O(2)-stimulated HK-2 cells.	Mycophenolic Acid	33-50	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
20181930-8	2010	In addition, OxLDL treatment stimulated ROCK2 catalytic activity, and ROCK2 inhibition attenuated NF-kappaB activation and IL-8 production resulting from OxLDL activation of LOX-1.	oxldl	154-159	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
20050751-11	2010	The presence of fluoride in artificial saliva was detrimental to the corrosion resistance of the test NiTi archwires, especially at a 0.5% NaF concentration.	Fluorides	16-24	C-X-C motif chemokine ligand 8	Homo sapiens	139-142
20406839-10	2010	Moreover, decreased microvessel density was observed, possibly secondary to increased expression of the antiangiogenic factor CXCL10 and decreased proangiogenic interleukin-8 cytokine in response to TRAIL/doxorubicin combination, as was also observed in vitro.	Doxorubicin	205-216	C-X-C motif chemokine ligand 8	Homo sapiens	161-174
20423350-5	2010	KEY RESULTS: Pre-incubation with beta(2)-adrenoceptor agonists (salbutamol, salmeterol, formoterol) augmented the release and mRNA expression of IL-6 and IL-8 induced by IL-1beta and IL-1beta plus histamine, whereas NF-kappaB-dependent transcription was significantly repressed, and AP-1-dependent transcription was unaffected.	Albuterol	64-74	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
20423350-5	2010	KEY RESULTS: Pre-incubation with beta(2)-adrenoceptor agonists (salbutamol, salmeterol, formoterol) augmented the release and mRNA expression of IL-6 and IL-8 induced by IL-1beta and IL-1beta plus histamine, whereas NF-kappaB-dependent transcription was significantly repressed, and AP-1-dependent transcription was unaffected.	Salmeterol Xinafoate	76-86	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
20423350-5	2010	KEY RESULTS: Pre-incubation with beta(2)-adrenoceptor agonists (salbutamol, salmeterol, formoterol) augmented the release and mRNA expression of IL-6 and IL-8 induced by IL-1beta and IL-1beta plus histamine, whereas NF-kappaB-dependent transcription was significantly repressed, and AP-1-dependent transcription was unaffected.	Formoterol Fumarate	88-98	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
20423350-8	2010	Addition of dexamethasone with salmeterol repressed IL-6 and IL-8 release to levels that were similar to the repression achieved in the absence of salmeterol.	Dexamethasone	12-25	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
20423350-8	2010	Addition of dexamethasone with salmeterol repressed IL-6 and IL-8 release to levels that were similar to the repression achieved in the absence of salmeterol.	Salmeterol Xinafoate	31-41	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
20423350-9	2010	IL-6 release was enhanced when salmeterol was added before, concurrently or after IL-1beta plus histamine stimulation, whereas IL-8 release was only enhanced by salmeterol addition prior to stimulation.	Salmeterol Xinafoate	161-171	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
20388003-8	2010	Budesonide significantly attenuated the release and expression of IL-6 and IL-8 after exposure.	Budesonide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
19788440-15	2010	Plasma interleukin-8 levels were significantly lower in the sivelestat-treated group than in the control group on POD 3 (P= 0.040).	sivelestat	60-70	C-X-C motif chemokine ligand 8	Homo sapiens	7-20
20388003-11	2010	Budesonide reduced IL-6 and IL-8 production and enhanced expression of TLR2 in PBECs only in the presence of a proinflammatory stimulus.	Budesonide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
20194598-7	2010	We observed that epithelial production of interleukin-8 (IL-8) and IL-6 in response to bacterial stimulation was significantly inhibited in the presence of CS (P &lt; 0.001 for inhibition by either CSC or CSE).	Cesium	156-158	C-X-C motif chemokine ligand 8	Homo sapiens	42-55
20019359-8	2010	CXCL8 secretion by LPS-treated IPE was dependent on CD14 and TLR4.	ipe	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
20194598-7	2010	We observed that epithelial production of interleukin-8 (IL-8) and IL-6 in response to bacterial stimulation was significantly inhibited in the presence of CS (P &lt; 0.001 for inhibition by either CSC or CSE).	Cesium	156-158	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
20164300-5	2010	Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-alpha, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-kappaB.	Tetradecanoylphorbol Acetate	80-111	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
20187772-9	2010	Muscle mRNA expression for IL-8 (6.4-fold), MCP-1 (4.7-fold), and IL-6 (7.3-fold) increased substantially after carbohydrate ingestion.	Carbohydrates	112-124	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
20002790-10	2010	NOD2 activation with MurNAc-l-Ala-d-isoGln (MDP) resulted in interleukin-8 secretion, CD62 ligand down-regulation, CD11b up-regulation and increased migration towards an inflammatory stimulus.	Acetylmuramyl-Alanyl-Isoglutamine	21-42	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
20002790-10	2010	NOD2 activation with MurNAc-l-Ala-d-isoGln (MDP) resulted in interleukin-8 secretion, CD62 ligand down-regulation, CD11b up-regulation and increased migration towards an inflammatory stimulus.	Acetylmuramyl-Alanyl-Isoglutamine	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
20164300-0	2010	Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-kappaB in activated human mast cells: suppression of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8.	butrin	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
20164300-5	2010	Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-alpha, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-kappaB.	Calcium	116-123	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
20164300-5	2010	Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-alpha, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-kappaB.	Calcimycin	134-140	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
20164300-0	2010	Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-kappaB in activated human mast cells: suppression of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8.	isobutrin	8-17	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
20019678-7	2010	Fasting glucose related to VAT expression of TNFalpha, MIP, serum amyloid A (SAA), IL-1alpha, IL-1beta, IL-8, and IL-8 receptor.	Glucose	8-15	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
20164300-0	2010	Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-kappaB in activated human mast cells: suppression of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8.	butein	23-29	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
20164300-5	2010	Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-alpha, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-kappaB.	butrin	24-30	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
20164300-5	2010	Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-alpha, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-kappaB.	isobutrin	32-41	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
20164300-5	2010	Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-alpha, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-kappaB.	butein	47-53	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
20639712-9	2010	The inflammatory biomarkers, erythrocyte sedimentation rate, and interleukin-8 decreased after supplementation with n-3 FA and erythrocyte sedimentation rate increased after supplementation with n-6 FA.	Fatty Acids, Omega-3	116-122	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
20019678-7	2010	Fasting glucose related to VAT expression of TNFalpha, MIP, serum amyloid A (SAA), IL-1alpha, IL-1beta, IL-8, and IL-8 receptor.	Glucose	8-15	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
20383325-9	2010	baumannii lipopolysaccharide stimulated IL-8 release by A549 cells and sCD14 facilitated the recognition of the lipopolysaccharide.	baumannii lipopolysaccharide	0-28	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
20084405-6	2010	To avoid dilution effects and to the standardize samples, urinary levels of IL-6 and IL-8 were expressed as the ratio of cytokine to urinary creatinine (pg/mg).	Creatinine	141-151	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
20176036-9	2010	In this study, we demonstrated that the up-regulated expressions of IL-8 or PGE(2) in Streptococci or PAMP-stimulated HDPF were inhibited by catechins, (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG).	Catechin	141-150	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
20176036-9	2010	In this study, we demonstrated that the up-regulated expressions of IL-8 or PGE(2) in Streptococci or PAMP-stimulated HDPF were inhibited by catechins, (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG).	epicatechin gallate	152-175	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
20176036-9	2010	In this study, we demonstrated that the up-regulated expressions of IL-8 or PGE(2) in Streptococci or PAMP-stimulated HDPF were inhibited by catechins, (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG).	epicatechin gallate	177-180	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
20176036-9	2010	In this study, we demonstrated that the up-regulated expressions of IL-8 or PGE(2) in Streptococci or PAMP-stimulated HDPF were inhibited by catechins, (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG).	epigallocatechin gallate	186-214	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
20176036-9	2010	In this study, we demonstrated that the up-regulated expressions of IL-8 or PGE(2) in Streptococci or PAMP-stimulated HDPF were inhibited by catechins, (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG).	epigallocatechin gallate	216-220	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
20084046-5	2010	Interleukin 6 mRNA expression in cultured islets, as well as IL-6, IL-8, and granulocyte-macrophage colony-stimulating factor released into the medium, was significantly reduced by adding SD-282.	indole-5-carboxamide	188-194	C-X-C motif chemokine ligand 8	Homo sapiens	67-125
20220108-6	2010	Arachidonic acid activated neutrophils to produce IL-8, which was completely inhibited by NS398.	Arachidonic Acid	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
20222014-8	2010	In addition, AC-treated MSC secreted interleukin (IL)-8, monocyte chemoattractant protein-1, and RANTES, which might induce chemotaxis of CD4+ T cells to the inflamed joints.	Charcoal	13-15	C-X-C motif chemokine ligand 8	Homo sapiens	37-55
20218918-5	2010	RESULTS: In the patients with PTF, maximum mean plasma IL-6 and IL-8 values were found, respectively at 24 h (45.12 pg/mL) and 6 hours (21.7 pg/mL) postoperatively.	Benzyl methyl sulfide	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
20218918-6	2010	Whereas, in the patients with FCF, it was respectively, at 12 h (33.1 pg/mL) and 6 h (17.0 pg/mL), for IL-6 and IL-8 post operatively.	3-[(1e,7e)-8-(2,6-Dioxo-1,2,3,6-Tetrahydropyrimidin-4-Yl)-3,6-Dioxa-2,7-Diazaocta-1,7-Dien-1-Yl]benzoic Acid	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
19597830-4	2010	Moreover, as we previously showed that epigallocatechin-3-gallate (EGCG) reduces VEGF and CXCL8/IL-8 secretion in TNFalpha-activated NHKs, we also tested its effect in association with GBE.	epigallocatechin gallate	39-65	C-X-C motif chemokine ligand 8	Homo sapiens	90-95
19597830-4	2010	Moreover, as we previously showed that epigallocatechin-3-gallate (EGCG) reduces VEGF and CXCL8/IL-8 secretion in TNFalpha-activated NHKs, we also tested its effect in association with GBE.	epigallocatechin gallate	39-65	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
19597830-4	2010	Moreover, as we previously showed that epigallocatechin-3-gallate (EGCG) reduces VEGF and CXCL8/IL-8 secretion in TNFalpha-activated NHKs, we also tested its effect in association with GBE.	epigallocatechin gallate	67-71	C-X-C motif chemokine ligand 8	Homo sapiens	90-95
19597830-4	2010	Moreover, as we previously showed that epigallocatechin-3-gallate (EGCG) reduces VEGF and CXCL8/IL-8 secretion in TNFalpha-activated NHKs, we also tested its effect in association with GBE.	epigallocatechin gallate	67-71	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
19597830-6	2010	In association with EGCG, GBE down-regulated VEGF and CXCL8/IL-8 levels in a cumulative manner in TNFalpha-stimulated NHKs.	epigallocatechin gallate	20-24	C-X-C motif chemokine ligand 8	Homo sapiens	54-59
19597830-6	2010	In association with EGCG, GBE down-regulated VEGF and CXCL8/IL-8 levels in a cumulative manner in TNFalpha-stimulated NHKs.	epigallocatechin gallate	20-24	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
19649704-7	2010	Thus, our study clearly demonstrated that doxorubicin-mediated cell death is obtained through expression of IL-8.	Doxorubicin	42-53	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
20110572-4	2010	METHODS AND RESULTS: THP-1 monocytes exposed to 100 micromol/L SFA in vitro for 16 hours followed by 1 ng/mL lipopolysaccharide demonstrated enhanced IL-6 and IL-8 mRNA and protein expression (approximately 3-fold higher than the sum of individual responses to SFA and lipopolysaccharide).	Fatty Acids	63-66	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
20233217-7	2010	In all but one mutation, the changes observed on antagonist affinity were matched with effects on inhibition of interleukin-8-stimulated [(35)S]GTPgammaS binding.	Guanosine 5'-O-(3-Thiotriphosphate)	144-153	C-X-C motif chemokine ligand 8	Homo sapiens	112-125
19649704-0	2010	Late phase activation of nuclear transcription factor kappaB by doxorubicin is mediated by interleukin-8 and induction of apoptosis via FasL.	Doxorubicin	64-75	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
19649704-4	2010	Further induction of NF-kappaB was observed through interleukin 8 (IL-8), expressed by doxorubicin treatment.	Doxorubicin	87-98	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
19649704-4	2010	Further induction of NF-kappaB was observed through interleukin 8 (IL-8), expressed by doxorubicin treatment.	Doxorubicin	87-98	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
19649704-8	2010	IL-8-mediated calcification is required for enhancement of doxorubicin-mediated cell death.	Doxorubicin	59-70	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19649704-6	2010	Anti-IL-8 or -FasL antibody, dominant negative TRAF6 (TRAF6-DN), or TRAF6 binding peptide (TRAF6-BP) inhibited doxorubicin-mediated late phase induction of NF-kappaB and diminished cell death.	Doxorubicin	111-122	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
19399612-6	2010	Collectively, MG132 blocked PaCa-derived VEGF and IL-8 production through inhibition of NF-kappaB activity.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	14-19	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
20397810-9	2010	IS-SCGB1A1/IL8 levels were also inversely associated with nitrogen slope [r = -0.52, p &lt; 0.001] and HRCT SA score [r = -0.51, p &lt; 0.001].	Nitrogen	58-66	C-X-C motif chemokine ligand 8	Homo sapiens	11-14
20397810-11	2010	The SCGB1A1/IL8 ratio measured in sputum is a potentially valuable biomarker for non-invasive assessment of SA remodelling in smokers.	sa	108-110	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
19399612-8	2010	Our studies show that MG132, a proteasome inhibitor, significantly blocked pancreatic-cancer-associated angiogenesis through inhibition of NF-kappaB and NF-kappaB-dependent proangiogenic gene products VEGF and IL-8.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	22-27	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
19840967-9	2010	At 10(-9) and 10(-10) M, GW-A, that had no direct effects, increased the inhibitory activity of dexamethasone (10(-8) and 10( -6) M) on LPS-induced IL-8 release in PBMCs from severe asthma.	Dexamethasone	96-109	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
20487003-6	2010	The presence of EGCG and ECG significantly reduced, in a concentration-dependent manner, the expression of IL-6 and IL-8 in dental pulp cells exposed to LPS or PG.	epigallocatechin gallate	16-20	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
20487003-6	2010	The presence of EGCG and ECG significantly reduced, in a concentration-dependent manner, the expression of IL-6 and IL-8 in dental pulp cells exposed to LPS or PG.	epicatechin gallate	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
19559500-7	2010	RESULTS: Lidocaine inhibited spontaneous and TNF-alpha induced secretion of IL-8 and IP-10.	Lidocaine	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
20119897-8	2010	RESULTS: Treatment of human islets with RvE1 (500 nM) for 24 h reduced LPS-induced increase in mRNA and protein levels of selected pro-inflammatory markers (IL-8, MCP-1, and TF).	lps	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
19559500-14	2010	CONCLUSION: Lidocaine inhibits IL-8 and IP-10 secretion from intestinal cells.	Lidocaine	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
20198307-0	2010	Involvement of capsular polysaccharide via a TLR2/NF-kappaB pathway in Vibrio vulnificus-induced IL-8 secretion of human intestinal epithelial cells.	capsular polysaccharide	15-38	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
20138154-4	2010	Hirsutenone, dexamethasone, ERK inhibitor or Bay 11-7085 (an inhibitor of NF-kappaB activation) reduced the lipopolysaccharide-induced production of cytokines IL-1beta and IL-8, and the chemokine CCL17.	hirsutenone	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
20138154-4	2010	Hirsutenone, dexamethasone, ERK inhibitor or Bay 11-7085 (an inhibitor of NF-kappaB activation) reduced the lipopolysaccharide-induced production of cytokines IL-1beta and IL-8, and the chemokine CCL17.	Dexamethasone	13-26	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
20138154-4	2010	Hirsutenone, dexamethasone, ERK inhibitor or Bay 11-7085 (an inhibitor of NF-kappaB activation) reduced the lipopolysaccharide-induced production of cytokines IL-1beta and IL-8, and the chemokine CCL17.	BAY 11-7085	45-56	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
20646342-9	2010	NTHi was able to potentiate the stimulatory actions of TNF-alpha on caspase-3 expression and, to a lesser extent, on IL-8 secretion.	nthi	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
20198307-3	2010	The CPS-defective wbpP mutant induced significantly lower levels of IL-8 production, IL-8 gene promoter activation and NF-kappaB activity in INT-407 cells than was noted with the wild-type or wbpP-complemented V. vulnificus.	cps	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
20198307-3	2010	The CPS-defective wbpP mutant induced significantly lower levels of IL-8 production, IL-8 gene promoter activation and NF-kappaB activity in INT-407 cells than was noted with the wild-type or wbpP-complemented V. vulnificus.	cps	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
20198307-6	2010	Furthermore, purified V. vulnificus CPS was found to significantly induce IL-8 production and NF-kappaB activation, both of which were inhibited upon the addition of the anti-TLR2 antibody.	cps	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
20198307-7	2010	Taken together, these results demonstrate that V. vulnificus capsular polysaccharide is involved in the induction of IL-8 production of human intestinal epithelial cells via a TLR2/NF-kappaB-dependent pathway.	vulnificus capsular polysaccharide	50-84	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
20194723-8	2010	Taken together, our results suggest that BLT2-Nox1-reactive oxygen species-dependent pathway plays a role in promoting the secretion of IL-8 from human mast cells in response to the proinflammatory cytokine IL-1beta, thus contributing to angiogenesis.	reactive	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
20194723-8	2010	Taken together, our results suggest that BLT2-Nox1-reactive oxygen species-dependent pathway plays a role in promoting the secretion of IL-8 from human mast cells in response to the proinflammatory cytokine IL-1beta, thus contributing to angiogenesis.	oxygen species	60-74	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
20204339-7	2010	Using receiver operating characteristics curve analysis, we found that the adjusted IL-8 level of 6.2 pg/mg creatinine can reach a sensitivity of 90% and specificity of 68% to detect urolithiasis.	Creatinine	108-118	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
20053934-7	2010	In addition, chromatin immunoprecipitation assays revealed that the DNA binding of NF-kappaB (p65) to il-8 promoter in RSF was induced after TNFalpha stimulation and that, upon CHPD treatment to RSF for 1 h, the NF-kappaB binding to il-8 promoter was significantly decreased.	(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol	119-122	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
20053934-7	2010	In addition, chromatin immunoprecipitation assays revealed that the DNA binding of NF-kappaB (p65) to il-8 promoter in RSF was induced after TNFalpha stimulation and that, upon CHPD treatment to RSF for 1 h, the NF-kappaB binding to il-8 promoter was significantly decreased.	(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol	119-122	C-X-C motif chemokine ligand 8	Homo sapiens	233-237
20308455-1	2010	PURPOSE: To evaluate the sensitivity of fluorine 18-labeled sodium fluoride ((18)F-NaF) positron emission tomography (PET) for assessment of skeletal trauma in pediatric patients suspected of having been abused and to compare the diagnostic performance of this examination with that of high-detail skeletal survey.	Fluorine	40-48	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
20308455-1	2010	PURPOSE: To evaluate the sensitivity of fluorine 18-labeled sodium fluoride ((18)F-NaF) positron emission tomography (PET) for assessment of skeletal trauma in pediatric patients suspected of having been abused and to compare the diagnostic performance of this examination with that of high-detail skeletal survey.	Sodium Fluoride	60-75	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
20660970-1	2010	BACKGROUND: This study was designed to compare 2% sodium fluoride (NaF) iontophoresis with other cavity liners.	Sodium Fluoride	50-65	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
20089808-7	2010	An aminopyridine-based JNK inhibitor, N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide (JNK inhibitor VIII), inhibited phosphorylation of a JNK substrate c-Jun but did not have any effect on IL-6, IL-8, or COX-2 expression.	Aminopyridines	3-16	C-X-C motif chemokine ligand 8	Homo sapiens	222-226
19898747-5	2010	Further, pretreatment of these cells with the highly specific MEK inhibitor (PD 098059), the JNK inhibitor (SP 600125), and the p38MAPK inhibitor (SB 203580) resulted in inhibition of the IL-8 secretion by EAEC (wild type as well as plasmid cured)-infected INT-407 cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	77-86	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
19898747-5	2010	Further, pretreatment of these cells with the highly specific MEK inhibitor (PD 098059), the JNK inhibitor (SP 600125), and the p38MAPK inhibitor (SB 203580) resulted in inhibition of the IL-8 secretion by EAEC (wild type as well as plasmid cured)-infected INT-407 cells.	pyrazolanthrone	108-117	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
19898747-5	2010	Further, pretreatment of these cells with the highly specific MEK inhibitor (PD 098059), the JNK inhibitor (SP 600125), and the p38MAPK inhibitor (SB 203580) resulted in inhibition of the IL-8 secretion by EAEC (wild type as well as plasmid cured)-infected INT-407 cells.	SB 203580	147-156	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
19919624-10	2010	tumor necrosis factor-alpha (P &lt; 0.04) and IL-8 were less (P &lt; 0.001) in the plasma from the PVS group, while IL-6 and IL-8 were less (P &lt; 0.04) in the lung tissue from ventilated lungs in the PVS group.	2-(phenylsulfonyl)ethanethiol	99-102	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
19919624-10	2010	tumor necrosis factor-alpha (P &lt; 0.04) and IL-8 were less (P &lt; 0.001) in the plasma from the PVS group, while IL-6 and IL-8 were less (P &lt; 0.04) in the lung tissue from ventilated lungs in the PVS group.	2-(phenylsulfonyl)ethanethiol	99-102	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
19733855-2	2010	The aim of this study was to determine if GSA induces chemokine, particularly CXCL8 (IL-8), and to determine intracellular signaling pathways activated by GSA in vascular smooth muscle cells (VSMCs).	gsa	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	78-83
20366434-1	2010	X-ray reflectometry reveals atomic layering at a liquid-liquid interface--mercury in a 0.01 M NaF solution.	Mercury	74-81	C-X-C motif chemokine ligand 8	Homo sapiens	94-97
20080229-3	2010	The in vitro effect of saponins on LPS-induced IL-8 and TNF-alpha mRNA level (by quantitative RT-PCR) and protein release (by ELISA) was evaluated in human THP-1 macrophages.	Saponins	23-31	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
20080229-4	2010	We found that compounds 1 (repandoside), 2 (deglucocyclamin) and 4 (anagalloside B) at 100 microM inhibited the LPS-induced IL-8 and TNF-alpha expressions.	repandoside	27-38	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
20080229-4	2010	We found that compounds 1 (repandoside), 2 (deglucocyclamin) and 4 (anagalloside B) at 100 microM inhibited the LPS-induced IL-8 and TNF-alpha expressions.	Deglucocyclamin	44-59	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
20080229-4	2010	We found that compounds 1 (repandoside), 2 (deglucocyclamin) and 4 (anagalloside B) at 100 microM inhibited the LPS-induced IL-8 and TNF-alpha expressions.	anagalloside B	68-82	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
20093183-8	2010	CSE (2.5-10%) induced upregulation of IL-6, IL-8 and Ang-2, and decreased Ang-1 expression in parallel to apoptosis which were partially suppressed by sildenafil, 8-Br-cGMP, DPI and NAC.	Sildenafil Citrate	151-161	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
20064484-2	2010	Human neutrophils produced IL-8 and TNF-alpha in response to stimulation with TLR agonists such as LPS and N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteinyl-seryl-(lysyl)(3)-lysine.	n-palmitoyl-s-[2,3-bis(palmitoyloxy)-(2rs)-propyl]-(r)-cysteinyl-seryl-(lysyl)(3)-lysine	107-195	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
20214814-5	2010	We found elevated levels of PGE2 and CXCL8 in subjects with PDAC, and chronic pancreatitis.	pdac	60-64	C-X-C motif chemokine ligand 8	Homo sapiens	37-42
20185670-0	2010	Ketamine inhibits transcription factors activator protein 1 and nuclear factor-kappaB, interleukin-8 production, as well as CD11b and CD16 expression: studies in human leukocytes and leukocytic cell lines.	Ketamine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	87-100
20185670-6	2010	Ketamine"s effect on interleukin-8 production was assessed in a whole blood assay.	Ketamine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	21-34
20185670-9	2010	Ketamine also reduced interleukin-8 production in whole blood and expression of CD11b and CD16 on neutrophils.	Ketamine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	22-35
19733855-2	2010	The aim of this study was to determine if GSA induces chemokine, particularly CXCL8 (IL-8), and to determine intracellular signaling pathways activated by GSA in vascular smooth muscle cells (VSMCs).	gsa	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
19733855-4	2010	GSA-induced promoter activation of the IL-8 gene was suppressed by dominant-negative mutants of TLR-4, MyD88, and TRIF, but not by a dominant-negative form of TLR-2.	gsa	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
19733855-5	2010	In addition, IL-8 up-regulation in response to GSA was inhibited by resveratrol, curcumin, diphenyleneiodium, U0126, and SB202190.	gsa	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
19733855-5	2010	In addition, IL-8 up-regulation in response to GSA was inhibited by resveratrol, curcumin, diphenyleneiodium, U0126, and SB202190.	Resveratrol	68-79	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
19733855-5	2010	In addition, IL-8 up-regulation in response to GSA was inhibited by resveratrol, curcumin, diphenyleneiodium, U0126, and SB202190.	Curcumin	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
19874800-7	2010	Moreover, the overproduction of IL-8 was associated with an enhanced increase in the translocation of NF-kappaB and an enhanced decrease in glutathione levels.	Glutathione	140-151	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
19733855-5	2010	In addition, IL-8 up-regulation in response to GSA was inhibited by resveratrol, curcumin, diphenyleneiodium, U0126, and SB202190.	diphenyleneiodium	91-108	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
19874800-9	2010	In conclusion, CSM exposure of macrophages up-regulates the expression and the production of IL-8 via reactive oxygen species and NF-kappaB activation.	Reactive Oxygen Species	102-125	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
19733855-5	2010	In addition, IL-8 up-regulation in response to GSA was inhibited by resveratrol, curcumin, diphenyleneiodium, U0126, and SB202190.	U 0126	110-115	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
19733855-5	2010	In addition, IL-8 up-regulation in response to GSA was inhibited by resveratrol, curcumin, diphenyleneiodium, U0126, and SB202190.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	121-129	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
19733855-8	2010	This study suggests that GSA induces expression of IL-8 in VSMCs and that TLR-4, mitogen-activated protein kinases, NF-kappaB, and NADPH oxidase are involved in that process.	gsa	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
20397120-8	2010	RESULTS: CO (2), but not hypoxia, induced a significant reduction in the release of TNF-alpha and IL-8 as well as a significant increase in the release of IL-10 and IL-1 beta within the first 4 h after incubation.	co (2)	9-15	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
20356455-5	2010	However, dsCpGDNA encapsulated with lipofectin induced IL-8 promoter activation, HLA-DRA expression, and IL-8 expression in a CG sequence- independent manner.	1,2-dielaidoylphosphatidylethanolamine	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
20356455-5	2010	However, dsCpGDNA encapsulated with lipofectin induced IL-8 promoter activation, HLA-DRA expression, and IL-8 expression in a CG sequence- independent manner.	1,2-dielaidoylphosphatidylethanolamine	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
19185976-3	2010	In vitro, Mox-LDL triggered the inflammatory response by increasing the release of both interleukin 8 (IL-8) and tumor necrosis factor alpha (TNF-alpha) by endothelial cells (ECs) and monocytes respectively.	mox-ldl	10-17	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
19185976-3	2010	In vitro, Mox-LDL triggered the inflammatory response by increasing the release of both interleukin 8 (IL-8) and tumor necrosis factor alpha (TNF-alpha) by endothelial cells (ECs) and monocytes respectively.	mox-ldl	10-17	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
19185976-9	2010	RESULTS AND LIMITATIONS: Two-way ANOVA analysis showed that TNF-alpha alone (p&lt;0.001) or Mox-LDL alone (p&lt;0.001) increased IL-8 production.	mox-ldl	92-99	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
19185976-11	2010	Tadalafil in combination with Mox-LDL and TNF-alpha showed a decrease of IL-8 (p&lt;0.05) compared with sildenafil and vardenafil.	Tadalafil	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
20008399-0	2010	Signal mechanisms of vascular endothelial growth factor and interleukin-8 in ovarian hyperstimulation syndrome: dopamine targets their common pathways.	Dopamine	112-120	C-X-C motif chemokine ligand 8	Homo sapiens	60-73
19185976-11	2010	Tadalafil in combination with Mox-LDL and TNF-alpha showed a decrease of IL-8 (p&lt;0.05) compared with sildenafil and vardenafil.	MOX	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
20008399-13	2010	Dopamine may block VEGF- and IL-8-induced endothelial permeability by inhibiting common VEGFR-2 dependent signals.	Dopamine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
20118277-6	2010	Elevated levels of intracellular reactive oxygen species triggered the production of IL-8 as well as proinflammatory cytokines, such as TNF-alpha and IL-6.	Reactive Oxygen Species	33-56	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
19259778-0	2010	Paricalcitol reduces basal and lipopolysaccharide-induced (LPS) TNF-alpha and IL-8 production by human peripheral blood mononuclear cells.	paricalcitol	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
19259778-10	2010	The effect of paricalcitol on IL-8 production was more profound.	paricalcitol	14-26	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
19259778-11	2010	Basal IL-8 concentration (1926 +/- 455 pg/ml) was reduced by paricalcitol (1273 +/- 472 pg/ml).	paricalcitol	61-73	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
19259778-13	2010	CONCLUSION: The in vitro inhibition of transforming growth factor alpha and interleukin 8 by paricalcitol confirms the immunomodulatory properties of this vitamin D analogue.	paricalcitol	93-105	C-X-C motif chemokine ligand 8	Homo sapiens	76-89
19259778-13	2010	CONCLUSION: The in vitro inhibition of transforming growth factor alpha and interleukin 8 by paricalcitol confirms the immunomodulatory properties of this vitamin D analogue.	Vitamin D	155-164	C-X-C motif chemokine ligand 8	Homo sapiens	76-89
20470276-9	2010	Iron induced significant increase in plasma malondialdehyde and IL-8 in monocytes, but had no effect on total antioxidant capacity, CD11b/CD18 expression, plasma IL-8, vWF and sICAM-1.	Iron	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
19815061-7	2010	ROS also triggered pro-inflammatory responses in cultured T98G cells, which were demonstrated by the increased gene expression and protein levels of IL-6 and IL-8.	ros	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
20184737-7	2010	A seemingly contradictory correlation was found between low IL-8 serum levels and a need for a PEG tube.	Polyethylene Glycols	95-98	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
20170497-17	2010	In general, treatment with silver-containing solutions resulted in decreased TNF-alpha and IL-8 expression, with increased IL-4, EGF, KGF, and KGF-2 expression.	Silver	27-33	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
20187163-4	2010	Images of vials containing different concentrations of sodium fluoride (NaF) were converted to units of moles by reference to precalibrated synthetically injected voxels.	Sodium Fluoride	55-70	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
22966296-0	2010	Down-regulation of IL-6, IL-8, TNF-alpha and IL-1beta by glucosamine in HaCaT cells, but not in the presence of TNF-alpha There is considerable evidence that glucosamine exerts an inhibitory effect on inflammatory cytokine expression in cells.	Glucosamine	57-68	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
22966296-0	2010	Down-regulation of IL-6, IL-8, TNF-alpha and IL-1beta by glucosamine in HaCaT cells, but not in the presence of TNF-alpha There is considerable evidence that glucosamine exerts an inhibitory effect on inflammatory cytokine expression in cells.	Glucosamine	158-169	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
22966296-5	2010	Our data showed that the expression of IL-6, IL-8, TNF-alpha and IL-1beta was decreased by glucosamine treatment in the HaCaT cells.	Glucosamine	91-102	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
22966296-7	2010	Notably, curcumin induced an increased expression of IL-8 and IL-1beta in the HaCaT cells, but not that of IL-6 and TNF-alpha.	Curcumin	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
22966296-8	2010	On the other hand, curcumin attenuated the expression of IL-6 and IL-8 in the TNF-alpha-treated HaCaT cells.	Curcumin	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
22966296-9	2010	Our data indicated that glucosamine induced the down-regulation of IL-6, IL-8, TNF-alpha and IL-1beta expression in the HaCaT cells.	Glucosamine	24-35	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
19655299-7	2010	Addition of ROC at different concentrations together with IFN-gamma and histamine induced a dose-dependent inhibition of ICAM-1 expression and MCP-1 and IL-8 release.	Saquinavir	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
19655299-7	2010	Addition of ROC at different concentrations together with IFN-gamma and histamine induced a dose-dependent inhibition of ICAM-1 expression and MCP-1 and IL-8 release.	Histamine	72-81	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
20052681-6	2010	By this method, 4-azido-L-phenylalanine was incorporated into human interleukin-8 at a specific site.	4-azidophenylalanine	16-39	C-X-C motif chemokine ligand 8	Homo sapiens	68-81
20506652-8	2010	The RT-PCR verified the mRNA expression of IL-6 and IL-8 was up-regulated until 48 h after treatment with paraquat.	Paraquat	106-114	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
20054232-4	2010	The reduced adhesion by GFW correlated with the suppressed expression of MCP-1 and IL-8, the major IBD-associated chemokines.	ethyl 2-[4-[4-(3-methylbutylsulfamoyl)phenyl]-1,3-thiazol-2-yl]ethanoate	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
20054232-9	2010	The results suggest that GFW ameliorates colon inflammation by suppressing production of TNF-alpha as well as its signaling through NF-kappaB leading to the expression of inflammatory chemokines, MCP-1 and IL-8.	ethyl 2-[4-[4-(3-methylbutylsulfamoyl)phenyl]-1,3-thiazol-2-yl]ethanoate	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	206-210
20102702-5	2010	Surprisingly, the variant with deletion of amino acids 220-320 (FliCDelta220-320) induced higher production of IL-8, MCP-1, and TNF-alpha, and showed higher mucosal adjuvancy than full-length FliC flagellin.	flicdelta220	64-76	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
20102702-5	2010	Surprisingly, the variant with deletion of amino acids 220-320 (FliCDelta220-320) induced higher production of IL-8, MCP-1, and TNF-alpha, and showed higher mucosal adjuvancy than full-length FliC flagellin.	flic flagellin	192-206	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
20083671-6	2010	In monocytes, UDP, but not leukotriene D(4), induced IL-8 production that was significantly inhibited by both drugs at micromolar concentrations.	Uridine Diphosphate	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
19647363-7	2010	Treatment of the cells with curcumin inhibited LPA-induced IL-6 and IL-8 secretion and STAT3 phosphorylation, leading to blocked ovarian cancer cell motility.	Curcumin	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
20140095-9	2010	Correspondingly, the interaction of Abeta(1-40) with HFA-GSLs is strongly inhibited by NaF, an efficient competitor of H-bond formation.	Glycosphingolipids	57-61	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
19945446-5	2010	These effects are ascribable to the fluoride content/release of glass powders, since they were mimicked by NaF solutions and were prevented by dimethyl sulfoxide and tempol (two radical scavengers), by superoxide dismutase (a superoxide scavenger), and by glutathione (the most important intracellular antioxidant molecule), but not by apocynin (an inhibitor of NADPH oxidase).	Fluorides	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	107-110
19945446-6	2010	The presence of fluoride-containing glasses and NaF caused also the generation of reactive oxygen species, which was prevented by superoxide dismutase and catalase.	Reactive Oxygen Species	82-105	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
19647363-7	2010	Treatment of the cells with curcumin inhibited LPA-induced IL-6 and IL-8 secretion and STAT3 phosphorylation, leading to blocked ovarian cancer cell motility.	lysophosphatidic acid	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
20103651-0	2010	Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma.	Sunitinib	58-67	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
19884117-7	2010	From receptor binding analysis AAL-glycan was found to bind IL-8 receptors especially CXCR2 directly and such binding could be blocked by 3"- or 2"-fucosyllactose.	aal-glycan	31-41	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
20103651-6	2010	Notably, escape coincided with increased secretion of interleukin-8 (IL-8) from tumors into the plasma, and coadministration of an IL-8 neutralizing antibody resensitized tumors to sunitinib treatment.	Sunitinib	181-190	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
20103651-7	2010	In patients who were refractory to sunitinib treatment, IL-8 expression was elevated in ccRCC tumors, supporting the concept that IL-8 levels might predict clinical response to sunitinib.	Sunitinib	177-186	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
20103651-7	2010	In patients who were refractory to sunitinib treatment, IL-8 expression was elevated in ccRCC tumors, supporting the concept that IL-8 levels might predict clinical response to sunitinib.	Sunitinib	177-186	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
20103651-8	2010	Our results reveal IL-8 as an important contributor to sunitinib resistance in ccRCC and a candidate therapeutic target to reverse acquired or intrinsic resistance to sunitinib in this malignancy.	Sunitinib	55-64	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
20103651-8	2010	Our results reveal IL-8 as an important contributor to sunitinib resistance in ccRCC and a candidate therapeutic target to reverse acquired or intrinsic resistance to sunitinib in this malignancy.	Sunitinib	167-176	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
19889021-9	2010	CBMC activation with the PAR-2 activating peptide resulted in an increased secretion of IL-8, but no histamine release was observed.	cbmc	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
19884117-7	2010	From receptor binding analysis AAL-glycan was found to bind IL-8 receptors especially CXCR2 directly and such binding could be blocked by 3"- or 2"-fucosyllactose.	3"- or 2"-fucosyllactose	138-162	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
20005571-7	2010	By contrast, STBM washed from the maternal side of a placental cotyledon and STBM shed by explants cultured in air up-regulated cell surface expression of the adhesion molecule CD54 and induced the production of interleukin (IL)-8, IL-6 and IL-1beta.	stbm	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	212-230
20065153-11	2010	RT-PCR showed a strong tumor necrosis factor alpha mRNA increase with IL-8 that was blocked by aldosterone, excluding the possibility that the tumor necrosis factor alpha increase was merely a consequence of secretion.	Aldosterone	95-106	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
20007751-5	2010	Cholecalciferol therapy reduced circulating levels of inflammatory cytokines, including IL-8, IL-6, and TNF.	Cholecalciferol	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
19648651-3	2010	This study investigates the effect of the lipid-rich surfactant preparations Survanta, Curosurf, and the major surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) on interleukin-8 (IL-8) gene and protein expression in human A549 lung epithelial cells using immunoassay and PCR techniques.	phospholipid dipalmitoylphosphatidylcholine	122-165	C-X-C motif chemokine ligand 8	Homo sapiens	176-189
19648651-3	2010	This study investigates the effect of the lipid-rich surfactant preparations Survanta, Curosurf, and the major surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) on interleukin-8 (IL-8) gene and protein expression in human A549 lung epithelial cells using immunoassay and PCR techniques.	phospholipid dipalmitoylphosphatidylcholine	122-165	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
19648651-3	2010	This study investigates the effect of the lipid-rich surfactant preparations Survanta, Curosurf, and the major surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) on interleukin-8 (IL-8) gene and protein expression in human A549 lung epithelial cells using immunoassay and PCR techniques.	1,2-Dipalmitoylphosphatidylcholine	167-171	C-X-C motif chemokine ligand 8	Homo sapiens	176-189
19648651-5	2010	The lipid-rich surfactant preparations Survanta, Curosurf, and DPPC, at physiological concentrations, significantly downregulated lipopolysaccharide (LPS)-induced IL-8 expression in A549 cells both at the mRNA and protein levels.	1,2-Dipalmitoylphosphatidylcholine	63-67	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
20043079-0	2010	Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells.	xanthohumol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	92-105
20026745-2	2010	Inflammation is mediated by inflammatory cytokines, including IL-8, which illustrates an increase in biological half-life and proinflammatory activity when bound to glycosaminoglycans (GAGs).	Glycosaminoglycans	165-183	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
20026745-3	2010	The aim of this project was to compare IL-8 and IL-18 for their relative stability, activity, and interaction with GAGs, including chondroitin sulfate, hyaluronic acid, and heparan sulfate, present in high quantities in the lungs of patients with CF.	Chondroitin Sulfates	131-150	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
20026745-3	2010	The aim of this project was to compare IL-8 and IL-18 for their relative stability, activity, and interaction with GAGs, including chondroitin sulfate, hyaluronic acid, and heparan sulfate, present in high quantities in the lungs of patients with CF.	Hyaluronic Acid	152-167	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
20026745-3	2010	The aim of this project was to compare IL-8 and IL-18 for their relative stability, activity, and interaction with GAGs, including chondroitin sulfate, hyaluronic acid, and heparan sulfate, present in high quantities in the lungs of patients with CF.	Heparitin Sulfate	173-188	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
20004976-4	2010	The agent displayed enhanced binding to GAG structures in vitro and could antagonize CXCL8-induced firm adhesion of monocytes as well as neutrophils to activated microvascular endothelium in physiologic flow assays.	Glycosaminoglycans	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	85-90
20005571-7	2010	By contrast, STBM washed from the maternal side of a placental cotyledon and STBM shed by explants cultured in air up-regulated cell surface expression of the adhesion molecule CD54 and induced the production of interleukin (IL)-8, IL-6 and IL-1beta.	stbm	77-81	C-X-C motif chemokine ligand 8	Homo sapiens	212-230
19722605-4	2010	The sol-gel matrices were produced via the NaF-catalyzed hydrolysis of a mixture of tetramethyoxysilane (TMOS) and methyltrimethoxysilane (MTMS), yielding nanohybrid matrices with controlled pore sizes, pore volumes, and surface chemistry.	tetramethyoxysilane	84-103	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
20022380-8	2010	Interestingly, IL-8 and ICAM-1 had a modest effect on neutrophil TEM in this 3h assay which was significantly diminished by the inhibition of Rho kinase in HUVECs with Y27632.	Tritium	77-79	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
20022380-8	2010	Interestingly, IL-8 and ICAM-1 had a modest effect on neutrophil TEM in this 3h assay which was significantly diminished by the inhibition of Rho kinase in HUVECs with Y27632.	Y 27632	168-174	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
19722605-4	2010	The sol-gel matrices were produced via the NaF-catalyzed hydrolysis of a mixture of tetramethyoxysilane (TMOS) and methyltrimethoxysilane (MTMS), yielding nanohybrid matrices with controlled pore sizes, pore volumes, and surface chemistry.	tetramethoxysilane	105-109	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
19722605-4	2010	The sol-gel matrices were produced via the NaF-catalyzed hydrolysis of a mixture of tetramethyoxysilane (TMOS) and methyltrimethoxysilane (MTMS), yielding nanohybrid matrices with controlled pore sizes, pore volumes, and surface chemistry.	methyltrimethoxysilane	115-137	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
19722605-4	2010	The sol-gel matrices were produced via the NaF-catalyzed hydrolysis of a mixture of tetramethyoxysilane (TMOS) and methyltrimethoxysilane (MTMS), yielding nanohybrid matrices with controlled pore sizes, pore volumes, and surface chemistry.	methyltrimethoxysilane	139-143	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
20098709-10	2010	The effects of the concentration of morphine found in serum of septic patients on LPS-induced release of IL-8 by human neutrophils were tested.	Morphine	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
20098709-13	2010	LPS and IL-8 were able to induce a significant release of morphine only in presence of Ca(2+).	Morphine	58-66	C-X-C motif chemokine ligand 8	Homo sapiens	8-12
20439185-0	2010	Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	76-89
20098709-15	2010	Low concentration of morphine (8 nM) significantly inhibited the release of IL-8 from neutrophils when coincubated with LPS.	Morphine	21-29	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
20098709-20	2010	Morphine concentrations equivalent to those found in the serum of septic patients significantly inhibited LPS-induced IL-8 secretion in neutrophils.	Morphine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
19799982-1	2010	AIM OF THE STUDY: In order to elucidate immunoregulatory mechanisms of Cordyceps militaris, a methanol extract of Cordyceps militaris grown on germinated soybeans was prepared and its immunoregulatory effect in the human lung epithelial cells was investigated by examining its ability to induce IL-8 expression.	Methanol	94-102	C-X-C motif chemokine ligand 8	Homo sapiens	295-299
19949019-8	2010	For example, increases in IL-8 with VCP, MMP-9 with CP, and VEGF with vandetanib monotherapy were associated with increased progression risk, and increase in intercellular adhesion molecule 1 with vandetanib was associated with decreased risk.	vandetanib	70-80	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
20439185-0	2010	Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures.	1 alpha,24-dihydroxyvitamin D3	38-48	C-X-C motif chemokine ligand 8	Homo sapiens	76-89
20439185-3	2010	The purpose of this study was to investigate the influence of 1alpha,25-dihydroxyvitamin D3 (calcitriol) and 1alpha,24(R)-dihydroxyvitamin D3 (tacalcitol) on the secretion of IL-6 and IL-8 by fibroblasts derived from NP.	Calcitriol	62-91	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
20439185-3	2010	The purpose of this study was to investigate the influence of 1alpha,25-dihydroxyvitamin D3 (calcitriol) and 1alpha,24(R)-dihydroxyvitamin D3 (tacalcitol) on the secretion of IL-6 and IL-8 by fibroblasts derived from NP.	1 alpha,24-dihydroxyvitamin D3	109-141	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
20439185-8	2010	RESULTS: Treatment with calcitriol or tacalcitol inhibits the synthesis of both IL-6 and IL-8 compared to the control group.	Calcitriol	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
20439185-8	2010	RESULTS: Treatment with calcitriol or tacalcitol inhibits the synthesis of both IL-6 and IL-8 compared to the control group.	1 alpha,24-dihydroxyvitamin D3	38-48	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
20439185-12	2010	CONCLUSIONS: The present study demonstrates that calcitriol and tacalcitol are capable of affecting pro-inflammatory cytokine (IL-6 and IL-8) levels in NP cultures.	Calcitriol	49-59	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
20439185-12	2010	CONCLUSIONS: The present study demonstrates that calcitriol and tacalcitol are capable of affecting pro-inflammatory cytokine (IL-6 and IL-8) levels in NP cultures.	1 alpha,24-dihydroxyvitamin D3	64-74	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
20439185-0	2010	Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures.	Calcitriol	23-33	C-X-C motif chemokine ligand 8	Homo sapiens	76-89
19595352-0	2010	Lovastatin inhibits oxidized L-A-phosphatidylcholine B-arachidonoyl-gamma-palmitoyl (ox-PAPC)-stimulated interleukin-8 mRNA and protein synthesis in human aortic endothelial cells by depleting stores of geranylgeranyl pyrophosphate.	Lovastatin	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	105-118
19346317-0	2010	Cell-bound IL-8 increases in bronchial epithelial cells after arylsulfatase B silencing due to sequestration with chondroitin-4-sulfate.	Chondroitin Sulfates	114-135	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
19346317-2	2010	To determine the role of chondroitin-4-sulfate (C4S) in mediating effects of IL-8, we silenced the enzyme N-acetylgalactosamine-4-sulfatase (arylsulfatase B [ASB]) that removes the 4-sulfate group from C4S, in the IB3-1 and C38 bronchial epithelial cell lines and in normal primary bronchial epithelial cells.	Chondroitin Sulfates	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
19834107-0	2010	Adenosine modulates HIF-1{alpha}, VEGF, IL-8, and foam cell formation in a human model of hypoxic foam cells.	Adenosine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
19346317-3	2010	When ASB was silenced and IL-8 production stimulated by exposure to TNF-alpha, ASB activity declined by roughly 75%, cellular C4S content increased by over 7.5 microg/mg protein, cell-bound IL-8 increased by over 530 pg/mg protein, and secreted IL-8 declined by over 520 pg/mg protein in all cell lines (P &lt; 0.001).	Chondroitin Sulfates	126-129	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
19346317-8	2010	These findings provide evidence for the influential role of ASB and C4S in the regulation of IL-8 secretion, and suggest that changes in ASB activity and C4S content may have a significant impact on IL-8-mediated inflammatory responses.	Chondroitin Sulfates	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
19346317-8	2010	These findings provide evidence for the influential role of ASB and C4S in the regulation of IL-8 secretion, and suggest that changes in ASB activity and C4S content may have a significant impact on IL-8-mediated inflammatory responses.	Chondroitin Sulfates	154-157	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
20113495-8	2010	RESULTS: After TNFalpha stimulation, the mRNA expression level of some of the genes under NF-kappaB control, such as interleukin (IL)-6 and IL-8, increased, while treatment with GlcN and NAPA reverted the effect.	Glucosamine	178-182	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
20113495-8	2010	RESULTS: After TNFalpha stimulation, the mRNA expression level of some of the genes under NF-kappaB control, such as interleukin (IL)-6 and IL-8, increased, while treatment with GlcN and NAPA reverted the effect.	Acecainide	187-191	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
19595352-0	2010	Lovastatin inhibits oxidized L-A-phosphatidylcholine B-arachidonoyl-gamma-palmitoyl (ox-PAPC)-stimulated interleukin-8 mRNA and protein synthesis in human aortic endothelial cells by depleting stores of geranylgeranyl pyrophosphate.	l-a-phosphatidylcholine b-arachidonoyl-gamma-palmitoyl	29-83	C-X-C motif chemokine ligand 8	Homo sapiens	105-118
19595352-1	2010	Human aortic endothelial cells (HAEC) exposed to 50 microg/ml oxidized L-A-phosphatidylcholine B-arachidonoyl-gamma-palmitoyl (ox-PAPC) for 6h increased in interleukin-8 mRNA and protein levels.	l-a-phosphatidylcholine b-arachidonoyl-gamma-palmitoyl	71-125	C-X-C motif chemokine ligand 8	Homo sapiens	156-169
19595352-4	2010	Addition of the geranylgeraniol (GGOL, 10 microM) but not farnesol (FOL, 10 microM), reversed the inhibitory effect of lovastatin on interleukin-8 mRNA and protein levels stimulated by ox-PAPC, indicating that lovastatin exerted its effect by inhibiting stores of geranylgeranyl pyrophosphate (GGPP) which are necessary for geranylgeranylation of proteins.	geranylgeraniol	16-31	C-X-C motif chemokine ligand 8	Homo sapiens	133-146
19595352-4	2010	Addition of the geranylgeraniol (GGOL, 10 microM) but not farnesol (FOL, 10 microM), reversed the inhibitory effect of lovastatin on interleukin-8 mRNA and protein levels stimulated by ox-PAPC, indicating that lovastatin exerted its effect by inhibiting stores of geranylgeranyl pyrophosphate (GGPP) which are necessary for geranylgeranylation of proteins.	geranylgeraniol	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	133-146
19595352-4	2010	Addition of the geranylgeraniol (GGOL, 10 microM) but not farnesol (FOL, 10 microM), reversed the inhibitory effect of lovastatin on interleukin-8 mRNA and protein levels stimulated by ox-PAPC, indicating that lovastatin exerted its effect by inhibiting stores of geranylgeranyl pyrophosphate (GGPP) which are necessary for geranylgeranylation of proteins.	Lovastatin	119-129	C-X-C motif chemokine ligand 8	Homo sapiens	133-146
20699615-12	2010	Surface fluoride concentration was significantly increased by native TiF(4), native and buffered AmF, buffered ZnF(2), and buffered NaF application.	Fluorides	8-16	C-X-C motif chemokine ligand 8	Homo sapiens	132-135
21526274-7	2010	Interleukin-8 secretion was significantly reduced after 24h incubation with the NO* donor, sodium nitroprusside.	Nitroprusside	91-111	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
21526274-10	2010	Inhibition of endogenous NO* with the nitric oxide synthase inhibitor N-nitro-L-arginine-methyl-ester caused an increase in IL-8 secretion by lipopolysaccharide- and cytokine-stimulated BEAS-2B cells.	nitric	38-44	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
21526274-10	2010	Inhibition of endogenous NO* with the nitric oxide synthase inhibitor N-nitro-L-arginine-methyl-ester caused an increase in IL-8 secretion by lipopolysaccharide- and cytokine-stimulated BEAS-2B cells.	n-nitro-l-arginine-methyl-ester	70-101	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
20332635-6	2010	In addition, DHMEQ induces a significant dose-dependent decrease in ICAM expression, MCP-1, RANTES, and IL-8 release.	dehydroxymethylepoxyquinomicin	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
19783455-6	2010	RESULTS: Dexamethasone inhibited LPS-stimulated release of TauNuFalpha, of IL-6, of IL-8 and of IL-10 in dose-dependent manner.	Dexamethasone	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
21063104-9	2010	In contrast, endothelial cells showed higher IL-6 and IL-8 release under co-culture conditions than in monolayers, with IL-8 production being largely suppressed by L-NMMA but not by 4-ABH(4).	N(G)-monomethylarginine acetate	164-170	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
20374186-7	2010	Cultures of human mononuclear leukocytes collected from six healthy volunteers showed 100 nM of azelnidipine caused significant inhibition of formyl-methyonyl leucyl phenylalanine (fMLP)-induced production of IL-8.	azelnidipine	96-108	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
20374186-7	2010	Cultures of human mononuclear leukocytes collected from six healthy volunteers showed 100 nM of azelnidipine caused significant inhibition of formyl-methyonyl leucyl phenylalanine (fMLP)-induced production of IL-8.	formyl-methyonyl leucyl phenylalanine	142-179	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
20472994-3	2010	In our previous study, it was found that PMMA-CHDF could efficiently remove various pro-inflammatory cytokines such as TNFalpha, IL-6 and IL-8 from the bloodstream, resulting in early recovery from septic shock.	pmma-chdf	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
20472995-7	2010	Significant correlations between changes in blood levels of cytokines (IL-6 and IL-8) and changes in RI were demonstrated in the PMMA-CHDF group.	Polymethyl Methacrylate	129-133	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
20472995-7	2010	Significant correlations between changes in blood levels of cytokines (IL-6 and IL-8) and changes in RI were demonstrated in the PMMA-CHDF group.	chdf	134-138	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
19165599-6	2010	Ethanol, but not acetaldehyde or PAEE, induced interleukin-8 production.	Ethanol	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	47-60
19906815-0	2010	Lysophosphatidic acid up-regulates expression of growth-regulated oncogene-alpha, interleukin-8, and monocyte chemoattractant protein-1 in human first-trimester trophoblasts: possible roles in angiogenesis and immune regulation.	lysophosphatidic acid	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	82-95
19906815-12	2010	LPA-induced IL-8 protein secretion of trophoblasts enhanced permeability, migration, proliferation, and capillary tube formation of human endometrial microvascular endothelial cells.	lysophosphatidic acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
19789931-7	2010	Moreover, AAS significantly inhibited production of inflammatory cytokines, tumor necrosis factor (TNF), interleukin (IL)-6, and IL-8 on the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells.	Tetradecanoylphorbol Acetate	141-172	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
19222504-7	2010	Grafts with hepatic IL-8 release exhibited subsequently higher alkaline phosphatase [319 (213-405) IU/L vs. 175 (149-208) IU/L, p = 0.006] and bilirubin [101 (44-139) micromol/L vs. 30 (23-72) micromol/L, p = 0.029] levels after transplantation.	Bilirubin	143-152	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
19789931-7	2010	Moreover, AAS significantly inhibited production of inflammatory cytokines, tumor necrosis factor (TNF), interleukin (IL)-6, and IL-8 on the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells.	Calcium	177-184	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
19250704-3	2010	In this study we investigated the production of the pro-inflammatory cytokines tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-8 (CXCL8) in these three cell types upon stimulation with lipoteichoic acid (LTA), a cell wall component of Gram-positive bacteria that activates the pattern recognition molecule Toll-like receptor 2 (TLR2).	lipoteichoic acid	224-241	C-X-C motif chemokine ligand 8	Homo sapiens	169-174
19752565-10	2010	Stimulation with poly(I:C) increased the percentage of CD11b+ cells and enhanced the secretion of IL-8, effects mediated via the p38 mitogen-activated protein kinases and nuclear factor-kappaB signaling pathways.	Poly I-C	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
19250704-3	2010	In this study we investigated the production of the pro-inflammatory cytokines tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-8 (CXCL8) in these three cell types upon stimulation with lipoteichoic acid (LTA), a cell wall component of Gram-positive bacteria that activates the pattern recognition molecule Toll-like receptor 2 (TLR2).	lipoteichoic acid	243-246	C-X-C motif chemokine ligand 8	Homo sapiens	169-174
19818417-9	2010	qPCR and ELISA showed that IL-8 levels were increased by CSE, with suppression by dexamethasone.	Dexamethasone	82-95	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
19752565-11	2010	Moreover, pretreatment with IL-5 augmented the poly(I:C)-induced IL-8 release.	Poly I-C	47-56	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
20871847-10	2010	In the active vitamin D group, we found a significant median percent decline in levels of GM-CSF (-62.9%, P &lt; .0001), IFN-gamma (-38.9%, P &lt; .0001), IL-4 (-50.8%, P = .001), IL-8 (-48.4%, P &lt; .0001), and IL-10 (-70.4%, P &lt; .0001).	Vitamin D	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
19672095-4	2010	METHODS: Rupatadine (1-50 microM) was used before stimulation by: (1) interleukin (IL)-1 to induce IL-6 from human leukemic mast cells (HMC-1 cells), (2) substance P for histamine, IL-8 and vascular endothelial growth factor release from LAD2 cells, and (3) IgE/anti-IgE for cytokine release from human cord blood-derived cultured mast cells.	rupatadine	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
19672095-7	2010	Rupatadine (10-50 microM for 10 min) inhibited IL-8 (80%), vascular endothelial growth factor (73%) and histamine (88%) release from LAD2 cells, as well as IL-6, IL-8, IL-10, IL-13 and tumor necrosis factor release from human cord blood-derived cultured mast cells.	rupatadine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
19672095-7	2010	Rupatadine (10-50 microM for 10 min) inhibited IL-8 (80%), vascular endothelial growth factor (73%) and histamine (88%) release from LAD2 cells, as well as IL-6, IL-8, IL-10, IL-13 and tumor necrosis factor release from human cord blood-derived cultured mast cells.	rupatadine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
19779130-5	2010	Acid forms of the nicotinamide glycolate were inactive in whole-cell assays of chemotaxis and calcium flux, but they inhibited (125)I-CXCL8/CXCR2 binding and CXCL1-stimulated [(35)S]GTPgammaS exchange.	nicotinamide glycolate	18-40	C-X-C motif chemokine ligand 8	Homo sapiens	134-139
20936184-0	2010	Induction by TNF-alpha of IL-6 and IL-8 in cystic fibrosis bronchial IB3-1 epithelial cells encapsulated in alginate microbeads.	Alginates	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
19880789-10	2010	Furthermore, cortisone decreased IL-6 (P &lt; 0.005), IL-8 (P &lt; 0.05), and macrophage chemoattractant protein-1 (P &lt; 0.05) production by cultured TAO cells only, an effect that was abrogated by inhibition of 11beta-HSD1.	Cortisone	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
19779130-3	2010	The data presented here describe the cellular pharmacology of the acid and ester forms of the nicotinamide glycolate pharmacophore, a potent antagonist of CXCR2 signaling by the chemokines CXCL1 and CXCL8.	Esters	75-80	C-X-C motif chemokine ligand 8	Homo sapiens	199-204
20634942-5	2010	The expression of CD11b/CD18 on neutrophils and E-selectin/ICAM-1 on HUVECs, and the adherence between neutrophils and HUVECs were significantly increased in 10 SP/MEC-CM, and the increments were significantly blocked by anti-IL-8 antibody.	mec	164-167	C-X-C motif chemokine ligand 8	Homo sapiens	226-230
19779130-3	2010	The data presented here describe the cellular pharmacology of the acid and ester forms of the nicotinamide glycolate pharmacophore, a potent antagonist of CXCR2 signaling by the chemokines CXCL1 and CXCL8.	nicotinamide glycolate	94-116	C-X-C motif chemokine ligand 8	Homo sapiens	199-204
19779130-4	2010	Ester forms of the nicotinamide glycolate antagonized CXCL1-stimulated chemotaxis (IC(50) = 42 nM) and calcium flux (IC(50) = 48 nM) in human neutrophils, but they were inactive in cell-free assays of (125)I-CXCL8/CXCR2 binding and CXCL1-stimulated guanosine 5"-O-(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS) exchange.	Esters	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	208-213
19779130-4	2010	Ester forms of the nicotinamide glycolate antagonized CXCL1-stimulated chemotaxis (IC(50) = 42 nM) and calcium flux (IC(50) = 48 nM) in human neutrophils, but they were inactive in cell-free assays of (125)I-CXCL8/CXCR2 binding and CXCL1-stimulated guanosine 5"-O-(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS) exchange.	nicotinamide glycolate	19-41	C-X-C motif chemokine ligand 8	Homo sapiens	208-213
21253500-7	2010	ELISA showed that KBG and paeoniflorin suppressed the production of MIF, IL-6, IL-8, and TNF-alpha in LPS-stimulated HDMECs.	peoniflorin	26-38	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
20634942-6	2010	CONCLUSION: MEC and IL-8 are major factors for neutrophil recruitment in nonallergic CRS.	Chromium	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
21103619-7	2010	RESULTS: The IL-2 production of T-lymphocytes was a deficient one (low seric levels in the majority of the patients), while cytokines IL-6, IL-8 and TNF-alpha showed high seric levels.	seric	171-176	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
20480060-0	2010	Release of fluoride from fresh and old NaF-impregnated chewing sticks (Miswaks) in vitro and oral retention in vivo.	Fluorides	11-19	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
20480060-1	2010	PURPOSE: The objectives of the present investigation were to study fluoride (F) release from NaF-impregnated chewing sticks (Miswaks) in vitro and to study the F clearance in saliva and the F oral retention in vivo.	Fluorides	67-75	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
20360623-0	2010	N-acetylcysteine inhibits IL-8 and MMP-9 release and ICAM-1 expression by bronchoalveolar cells from interstitial lung disease patients.	Acetylcysteine	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
20360623-7	2010	NAC exerted a dose-dependent inhibitory effect on IL-8 and MMP-9 release and ICAM- expression by BAL macrophages and lymphocytes from patients with IPF and sarcoidosis.	Acetylcysteine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
20703999-8	2010	In contrast, IL-8 concentration in EBC (pg/ml) decreased after FOB (0.073 +/- 0.13 v. 0.061 +/- 0.1, p = 0.006) and was significantly lower than in BALF (BALF 0.95 +/- 0.62, p &lt; 0.05).	NSC638702	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
19816000-3	2010	OBJECTIVES: The aim of the study was to determine whether the pH , electrical conductivity and the levels of ammonium and interleukin 8 (IL-8) of EBC were altered in smokers and whether they changed after smoking a single cigarette.	NSC638702	146-149	C-X-C motif chemokine ligand 8	Homo sapiens	122-135
19816000-3	2010	OBJECTIVES: The aim of the study was to determine whether the pH , electrical conductivity and the levels of ammonium and interleukin 8 (IL-8) of EBC were altered in smokers and whether they changed after smoking a single cigarette.	NSC638702	146-149	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
19887769-2	2010	OBJECTIVE: To test the hypothesis that clinically relevant concentrations of ibuprofen suppress activation of nuclear factor (NF)-kappaB and thus down-regulate stimulated interleukin (IL)-8 production in CF respiratory epithelial cells.	Ibuprofen	77-86	C-X-C motif chemokine ligand 8	Homo sapiens	171-189
19887769-6	2010	NF-kappaB and IL-8 suppression by ibuprofen (480 microM) was compared to dexamethasone (5 nM).	Ibuprofen	34-43	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
19887769-10	2010	By contrast, dexamethasone significantly down-regulated stimulated IL-8 mRNA and protein.	Dexamethasone	13-26	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
19887769-13	2010	We speculate that NF-kappaB-independent mechanisms may be responsible for anti-IL-8 effects of dexamethasone.	Dexamethasone	95-108	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
20615159-9	2010	IL-6, TNF, and IL-8 were higher in patients vs. controls before treatment (p &lt; 0.05&amp;#x2013;0.001), and decreased after treatment in patients (p &lt; 0.001) but did not change in controls.	Adenosine Monophosphate	87-90	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
20090409-4	2010	Quantitative PCR analysis was used to detect gene expression changes, particularly of interleukin (IL) 8, as an indicator of differential dendritic cell (DC) gene expression after sensitizer stimulation in the absence or presence of tacrolimus and betamethasone at two different concentrations.	Betamethasone	248-261	C-X-C motif chemokine ligand 8	Homo sapiens	86-104
20238282-6	2010	The fluoride uptake was slightly higher when the enamel samples were brushed with NaF toothpaste, rather than just stored in the respective toothpaste slurry.	Fluorides	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
20090409-6	2010	Betamethasone and, to a lesser extent, tacrolimus led to a marked reduction of chemical-induced IL-8 expression by TNBS and CAld.	Betamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
20090409-6	2010	Betamethasone and, to a lesser extent, tacrolimus led to a marked reduction of chemical-induced IL-8 expression by TNBS and CAld.	Tacrolimus	39-49	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
20090409-6	2010	Betamethasone and, to a lesser extent, tacrolimus led to a marked reduction of chemical-induced IL-8 expression by TNBS and CAld.	Trinitrobenzenesulfonic Acid	115-119	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
21341456-6	2010	CONCLUSION: The elevated levels of IL-6, IL-16, alpha-TNF, and the chemokine IL-8 with the lower blood content of the cytokine IL-4 were long before the development of DM1 in children with normal blood glucose level in the presence of LIAA, which should be borne in mind while developing the immune mechanisms specifically directed against block, which participate by means of cytokines in beta-cell destruction, as well as methods for preventing the development of T1DM in subjects with LIAA.	Glucose	202-209	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
20025541-10	2010	CONCLUSION: We have demonstrated that iodide stimulates thyroid follicular cells to produce chemokines, particularly CCL2, CXCL8, and CXCL14.	Iodides	38-44	C-X-C motif chemokine ligand 8	Homo sapiens	123-128
20056081-0	2010	[Relationship of IL-6 and IL-8 secretion in epithelial ovarian cancer cell lines with their sensitivity to tamoxifen as well as MAPK, Akt and estrogen receptor phosphorylation].	Tamoxifen	107-116	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
20002897-9	2010	DEX dose dependently down-regulated basal and MMC-induced interleukin-8 and monocyte chemoattractant protein-1 mRNA expression and protein secretion.	Dexamethasone	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	58-71
20002897-11	2010	These suggested that DEX may inhibit MMC-induced interleukin-8 and monocyte chemoattractant protein-1 by up-regulating MKP-1 expression, which subsequently deactivated p38 and Jun N-terminal kinases activation.	Dexamethasone	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	49-62
20002897-11	2010	These suggested that DEX may inhibit MMC-induced interleukin-8 and monocyte chemoattractant protein-1 by up-regulating MKP-1 expression, which subsequently deactivated p38 and Jun N-terminal kinases activation.	Mitomycin	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	49-62
20056081-1	2010	AIM: To investigate the relationship of IL-6 and IL-8 secretion in four epithelial ovarian cancer cell lines (A2780, CAOV-3, SKOV-3 and ES-2) with their sensitivity to tamoxifen (TAM) as well as MAPK, Akt and estrogen receptor (ER) phosphorylation, and to explore the mechanism of endocrine therapy resistance caused by IL-6 and IL-8 in ovarian cancer cells.	Tamoxifen	168-177	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
20056081-10	2010	CONCLUSION: Autocrine production of IL-6 and IL-8 in epithelial ovarian cancer cell lines is inversely associated with cell response to TAM, and positively associated with phosphorylated MAPK, Akt and ER.	Tamoxifen	136-139	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
19951001-8	2009	Sesamin also attenuated the oxLDL-induced activation of NF-kappaB, suggesting that the inhibitory effects of sesamin on IL-8 and ET-1 release, adhesion molecule expression, and the adherence of THP-1 cells were at least partially through the blockade of NF-kappaB activation.	sesamin	109-116	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
19880520-4	2009	Hypoxia enhanced interleukin-1beta-induced interleukin-8 (CXCL8) production in A549 cells and decreased the ability of dexamethasone to suppress the CXCL8 production.	Dexamethasone	119-132	C-X-C motif chemokine ligand 8	Homo sapiens	149-154
19688831-6	2009	Plasma IL-8 correlated strongly to plasma citrulline (n = 46, rho = -0.627; P &lt; 0.001).	Citrulline	42-52	C-X-C motif chemokine ligand 8	Homo sapiens	7-11
19836502-3	2009	Running buffer containing 40 mmol/L 1-butyl-3-methylimidazolium tetrafluoroborate (BMImBF(4)) IL-8 mmol/L phosphate resulted in significant changes in separation selectivity for alkaloids with similar structures.	1-butyl-3-methylimidazolium tetrafluoroborate	36-81	C-X-C motif chemokine ligand 8	Homo sapiens	83-98
19836502-3	2009	Running buffer containing 40 mmol/L 1-butyl-3-methylimidazolium tetrafluoroborate (BMImBF(4)) IL-8 mmol/L phosphate resulted in significant changes in separation selectivity for alkaloids with similar structures.	Phosphates	106-115	C-X-C motif chemokine ligand 8	Homo sapiens	83-98
19836502-3	2009	Running buffer containing 40 mmol/L 1-butyl-3-methylimidazolium tetrafluoroborate (BMImBF(4)) IL-8 mmol/L phosphate resulted in significant changes in separation selectivity for alkaloids with similar structures.	Alkaloids	178-187	C-X-C motif chemokine ligand 8	Homo sapiens	83-98
19968887-7	2009	With regard to extravasation we found norepinephrine to induce adhesion of activated CD8+ T cells: norepinephrine increased the interleukin-8 release from endothelium, which in turn had effect on the activated CXCR1+ CD8+ T cells.	Norepinephrine	38-52	C-X-C motif chemokine ligand 8	Homo sapiens	128-141
19968887-7	2009	With regard to extravasation we found norepinephrine to induce adhesion of activated CD8+ T cells: norepinephrine increased the interleukin-8 release from endothelium, which in turn had effect on the activated CXCR1+ CD8+ T cells.	Norepinephrine	99-113	C-X-C motif chemokine ligand 8	Homo sapiens	128-141
20015351-8	2009	Dose-response measurements with ZnO nanoparticles (0.3-8.5 mug/cm(2)) showed significant differences in mRNA expression of pro-inflammatory (IL-8) and oxidative stress (HO-1) markers when comparing submerged and air-liquid interface exposures.	Zinc Oxide	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
20016852-10	2009	In addition, polymorphism CXCR1_G827C was associated with increased CXCL-8 levels in women with ASB (P = 0.004).	asb	96-99	C-X-C motif chemokine ligand 8	Homo sapiens	68-74
20003431-4	2009	RESULTS: Congaplex enhanced phytohemagglutinin/phorbol 12-myristate 13-acetate (PHA/PMA) stimulation of both CEM and Jurkat cells as measured by the production of cytokines, while Immuplex suppressed PHA/PMA-induced production of cytokines, with the exception of interleukin (IL)-8 which was enhanced by Immuplex.	congaplex	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	263-281
19826413-8	2009	In MyD88(+) SCOV3 cells, LPS or PTX binding to TLR4 induced IRAK4 activation and cJun phosphorylation, activated the NF-kappaB pathway and promoted interleukin (IL)-8, IL-6, vascular endothelial growth factor and monocyte chemotactic protein-1 production and resistance to drug-induced apoptosis.	Paclitaxel	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	148-166
19265173-8	2009	Application of alpha,beta-meATP or BzATP at the apical side of polarized human primary nasal epithelial cells sufficed to cause CaMK-dependent IL-8 release by these cells.	BzATP	35-40	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
19779021-5	2009	Using the cytokine IL-8 as a physiological read out of the inflammatory response, we found that TLR3 is the most functional of the expressed TLRs in both primary and immortalized esophageal epithelial cell lines in response to its synthetic ligand polyinosinic polycytidylic acid [poly(I:C)].	Poly I-C	248-279	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
19779021-6	2009	Through reporter gene studies, we show that poly(I:C)-induced NF-kappaB activation is critical for the transactivation of the IL-8 promoter in vitro and that nuclear translocation of NF-kappaB occurs at an early time point following poly(I:C) stimulation of esophageal epithelial cells.	Poly I-C	44-53	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
19779021-6	2009	Through reporter gene studies, we show that poly(I:C)-induced NF-kappaB activation is critical for the transactivation of the IL-8 promoter in vitro and that nuclear translocation of NF-kappaB occurs at an early time point following poly(I:C) stimulation of esophageal epithelial cells.	Poly I-C	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
19265173-2	2009	The aim of our study was to investigate the molecular mechanisms involved in the ATP-dependent regulation of IL-8 production by airway epithelial cells.	alpha,beta-methyleneadenosine 5'-triphosphate	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
19265173-6	2009	Both alpha,beta-meATP and BzATP caused Ca(2+)-dependent binding of phosphorylated p65 (S536) NF-kappaB subunit to the endogenous IL-8 gene promoter in NT-1 cells.	BzATP	26-31	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
19265173-9	2009	Thus, ATP promotes TNF-alpha-elicited IL-8 expression through P2X ion channel-triggered Ca(2+) entry, leading to CaMK-dependent IKK activation and binding of active p65 to IL-8 gene promoter.	alpha,beta-methyleneadenosine 5'-triphosphate	6-9	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
19265173-9	2009	Thus, ATP promotes TNF-alpha-elicited IL-8 expression through P2X ion channel-triggered Ca(2+) entry, leading to CaMK-dependent IKK activation and binding of active p65 to IL-8 gene promoter.	alpha,beta-methyleneadenosine 5'-triphosphate	6-9	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
19799602-9	2009	The main mechanism of E(2) protection in NaF exposure appeared to be connected with the influence of E(2 )on thiol group levels, not (*)OH scavenging ability.	Estradiol	101-106	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
20112520-1	2009	OBJECTIVES: We assessed the effect of using preoperative sodium fluoride (NaF) on the difficulty of working with the footplate during stapedectomy and its effect on the postsurgical hearing gain in patients with mixed otosclerosis (i.e., otosclerosis and/or otospongiosis).	Sodium Fluoride	57-72	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
19799602-9	2009	The main mechanism of E(2) protection in NaF exposure appeared to be connected with the influence of E(2 )on thiol group levels, not (*)OH scavenging ability.	Sulfhydryl Compounds	109-114	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
20050188-10	2009	BK-induced IL-8 release was attenuated by inhibitors of phospholipase C (U73122), p38 (SB203580), JNK (SP600125), ERK 1/2 (PD98059) MAPKs, phosphoinositide 3-kinase (LY294002), NF-kappaB (BAY-117085) and by the glucocorticoid dexamethasone.	SB 203580	87-95	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
20050188-10	2009	BK-induced IL-8 release was attenuated by inhibitors of phospholipase C (U73122), p38 (SB203580), JNK (SP600125), ERK 1/2 (PD98059) MAPKs, phosphoinositide 3-kinase (LY294002), NF-kappaB (BAY-117085) and by the glucocorticoid dexamethasone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
20050188-10	2009	BK-induced IL-8 release was attenuated by inhibitors of phospholipase C (U73122), p38 (SB203580), JNK (SP600125), ERK 1/2 (PD98059) MAPKs, phosphoinositide 3-kinase (LY294002), NF-kappaB (BAY-117085) and by the glucocorticoid dexamethasone.	Dexamethasone	226-239	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
19917067-11	2009	While SLIGKV-induced IL-8 formation was reduced by both SB203580 and YM-254890, the response to K-14585 was sensitive to SB203580 but not YM-254890.	SB 203580	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
19917067-11	2009	While SLIGKV-induced IL-8 formation was reduced by both SB203580 and YM-254890, the response to K-14585 was sensitive to SB203580 but not YM-254890.	YM-254890	69-78	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
19773182-8	2009	CONCLUSIONS: In adolescents with T1DM and chronic, poor glucose control, increased serum IL-8 is associated with reduced IGF-1 suggesting a pro-inflammatory milieu that may contribute to alterations in the GH/IGF-1 axis.	Glucose	56-63	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
19863450-8	2009	The IL-8 level was lower in tampons from women without vaginal S. aureus compared with women with S. aureus and was lower in study tampons with GML than in study tampons without GML.	monolaurin	144-147	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
19863450-8	2009	The IL-8 level was lower in tampons from women without vaginal S. aureus compared with women with S. aureus and was lower in study tampons with GML than in study tampons without GML.	monolaurin	178-181	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
19567495-9	2009	Desmosine levels were positively associated with plasma C-reactive protein (rho = 0.59; p = 0.03), sputum interleukin-8 (rho = 0.86; p &lt; 0.01), and sputum neutrophil elastase (rho = 0.78; p &lt; 0.01).	Desmosine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	106-119
19863450-3	2009	The purpose of this study was to determine whether GML, as a tampon fiber finish, inhibits production of exotoxins and the cytokine interleukin 8 (IL-8) during normal tampon use.	monolaurin	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
19683936-14	2009	CONCLUSION: Compared with simple cold blood cardioplegia in heart valve replacement patients, ADO pretreatment as an adjunct to 1 mmol l(-1) ADO cold blood cardioplegia may reduce cTnI, IL-6 and IL-8 release, resulting in reduced myocardial injury in ultrastructure after surgery.	Adenosine	94-97	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
19643964-8	2009	The induced caspase-4 and caspase-3 activities by tunicamycin and the stimulated IL-8 protein expression by IL-1beta were markedly reduced by caspase-4 inhibitor Z-LEVD-fmk.	Z-LEVD-FMK	162-172	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
19830732-4	2009	Butyrate was found to enhance PGN-mediated IL-8 and GRO-alpha production.	Butyrates	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
19460789-6	2009	In these cells, methacholine also significantly augmented IL-8 secretion in combination with cigarette smoke extract in a synergistic manner, whereas synergistic effects on IL-6 secretion were not significant.	Methacholine Chloride	16-28	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
19460789-7	2009	Muscarinic M3 receptors were the primary subtype involved in augmenting cigarette smoke extract-induced IL-8 secretion, as only tiotropium bromide and muscarinic M3 receptor subtype selective antagonists abrogated the effects of methacholine.	Methacholine Chloride	229-241	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
19748599-0	2009	Serum levels of IL-8 and IL-6 in the long term pulmonary complications induced by sulfur mustard: Sardasht-Iran Cohort Study.	Mustard Gas	82-96	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
19926600-11	2009	RBP 4 was positively correlated with IL-8 (r=0.416, P &lt; 0.05) in human plasma in patients with DCMi.	dcmi	98-102	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
19926600-14	2009	CONCLUSION: Elevated RBP 4 plasma concentrations, induced by IL-8, might be one mechanism leading to a higher incidence of diabetes in patients with DCMi.	dcmi	149-153	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
20065508-0	2009	IL-6 and IL-8 responses of colorectal cancer in vivo and in vitro cancer cells subjected to simvastatin.	Simvastatin	92-103	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
19602125-4	2009	MATERIAL AND METHODS: Differences in the expression of interleukin-1, interleukin-8 and RANKL mRNAs, in response to exposure to various concentrations of nicotine (0, 0.125, 0.25, 0.5 and 1 mm) were evaluated in U2OS cells using the reverse transcription-polymerase chain reaction.In addition, the levels of interleukin-1, interleukin-8 and RANKL proteins were determined using enzyme-linked immunosorbent assays.	Nicotine	154-162	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
19602125-6	2009	RESULTS: Nicotine was found to increase the expression of interleukin-1, interleukin-8 and RANKL mRNA and protein in U2OS cells (p &lt; 0.05).	Nicotine	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	73-86
19897783-5	2009	In human gingival fibroblasts, cyclosporin alone did not induce evident inflammatory responses, but augmented the expression of CD54 and the production of interleukin (IL)-6 and IL-8 induced by TLR ligands, whereas phenytoin attenuated those responses.	Cyclosporine	31-42	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
19915063-5	2009	We found that iloprost inhibited IFN-gamma- and IL-6-induced MCP-1, IL-8, RANTES, and TNF-alpha production in monocytes, indicating wide-ranging anti-inflammatory action.	Iloprost	14-22	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
20065508-6	2009	Treatment of CRC with simvastatin (80 mg/day for 14 days) led to a significant decrease of serum IL-6, while the IL-8 level was less affected.	Simvastatin	22-33	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
20388952-0	2009	Nitric oxide-induced IL-8 expression is mediated by NF-kappaB and AP-1 in gastric epithelial AGS cells.	Nitric Oxide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
20065508-7	2009	The in vitro experiments on colorectal cancer-derived cell lines (HT-29 and Caco-2) demonstrated that application of simvastatin decreased generation of both IL-6 and IL-8.	Simvastatin	117-128	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
20065508-9	2009	We conclude that 1) colorectal carcinogenesis is accompanied by increased synthesis and release of proinflammatory cytokines such as IL-6 and IL-8; 2) simvastatin therapy results in a decrease in serum level of proinflammatory cytokines, especially IL-6 in CRC and 3) simvastatin inhibits release of IL-8 and IL-6 from colorectal cell lines.	Simvastatin	151-162	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
20065508-9	2009	We conclude that 1) colorectal carcinogenesis is accompanied by increased synthesis and release of proinflammatory cytokines such as IL-6 and IL-8; 2) simvastatin therapy results in a decrease in serum level of proinflammatory cytokines, especially IL-6 in CRC and 3) simvastatin inhibits release of IL-8 and IL-6 from colorectal cell lines.	Simvastatin	151-162	C-X-C motif chemokine ligand 8	Homo sapiens	300-304
20046083-2	2009	Recent guidelines advocate two kinds of methods for sample collection and processing: either the sodium fluoride (NaF) method or immediate refrigeration using a serum separation tube (SST).	Sodium Fluoride	97-112	C-X-C motif chemokine ligand 8	Homo sapiens	114-117
20046083-9	2009	NaF glucose showed a negative mean bias of 2.6 mg/dL vs SST glucose but showed high correlation (R=0.9899).	Glucose	4-11	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
19811837-6	2009	As shown by neutrophils from an IRAK-4-deficient patient, the zymosan-induced IL-8 release was also independent of TLR2.	Zymosan	62-69	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
19786303-3	2009	IL-8 expression was inhibited by nystatin (a lipid rafts inhibitor) but not by chlorpromazine (a clathrin-coated pits inhibitor).	Nystatin	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19956406-6	2009	RESULTS: Incubation of HCFs with hydrocortisone markedly inhibited the expression of TLR2 and TLR4 mRNAs and decreased the release of IL-6 and IL-8 in a dose-dependent manner.	Hydrocortisone	33-47	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
19810018-5	2009	Furthermore, naringin suppressed TNF-alpha-mediated release of interleukin-6 and -8 (IL-6 and IL-8).	naringin	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
19583958-10	2009	SB202190 successfully suppressed IL-6, IL-8, PGE2, and PGF2alpha secretion in macrophage-exposed AF cells in response to TNF-alpha.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
19670249-9	2009	Transcription up-regulation of IL-6 and IL-8 was associated with re-expression of the serine active-site mutant prostasin in the PC-3 cells.	Serine	86-92	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
19732821-5	2009	In response to 100 microM nickel sulphate MUTZ-3 DC revealed slightly upregulated mRNA levels after 24h, whereas 300 microM induced transcription of CCL3, CCL3L1 and IL8 significantly after 6 or 10h.	nickel sulfate	26-41	C-X-C motif chemokine ligand 8	Homo sapiens	166-169
19801670-4	2009	In the present study, we assessed whether AMF promotes melanoma cell migration through autocrine production of IL-8.	amf	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
20214329-7	2009	CONCLUSION: Injecting puerarin before CPB could effectively suppress the pro-inflammatory cytokines like TNF-alpha, IL-6 and IL-8; and enhance the expression of anti-inflammatory cytokines like IL-10, thus to alleviate the inflammatory reaction induced by CPB.	puerarin	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
19956406-8	2009	The result of ELISA also showed the release of IL-6 and IL-8 can also be inhibited by hydrocortisone.	Hydrocortisone	86-100	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
20214221-7	2009	Lovastatin administration resulted in the significant decrease of the pro-inflammatory cytokines IL-6 and TNF-alfa, while that of fluvastatin brought about the significant decrease of the serum levels of IL-6, IL-8 and TNF-alfa.	Fluvastatin	130-141	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
19930544-11	2009	The concentrations of interleukin-8 were significantly correlated with increasing organic carbon concentrations.	Carbon	90-96	C-X-C motif chemokine ligand 8	Homo sapiens	22-35
19799411-5	2009	Sodium or lithium salts gave products, except with NaF, where silver fluoride in nitromethane was best for substitution by fluoride.	silver fluoride	62-77	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
19799411-5	2009	Sodium or lithium salts gave products, except with NaF, where silver fluoride in nitromethane was best for substitution by fluoride.	Fluorides	69-77	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
19809428-8	2009	AZ10397767 increased 17-AAG-induced apoptosis and necrosis and decreased NF-kappaB activity/CXCL8 expression in 17-AAG-treated PC3 cells.	tanespimycin	112-118	C-X-C motif chemokine ligand 8	Homo sapiens	92-97
19750480-4	2009	Neutrophils pretreated with CXCL8, a chemokine that binds both CXCR1/2, completely blocked the calcium mobilization in response to LL-37, while LL-37 also partially inhibited (125)I-CXCL8 binding to neutrophils.	Calcium	95-102	C-X-C motif chemokine ligand 8	Homo sapiens	28-33
19855073-9	2009	Taken together, the production of IL-8 by SPE B in A549 cells is mediated by Fas, and followed by the activation of FADD, caspase 8, MEKK1, ERK and NF-kappaB.	ammonium ferrous sulfate	77-80	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
19446037-6	2009	Using proteosome inhibitor MG132 and I kappaB overexpression we demonstrated that an NF-kappaB-dependent mechanism was involved in both the activation of IL-8 and the repression of MCP-1 mRNA expression in response to hypoxia.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	27-32	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
19720161-0	2009	Modulation of expression of IL-8 gene in bronchial epithelial cells by 5-methoxypsoralen.	5-Methoxypsoralen	71-88	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
19787256-0	2009	Cepharanthine inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing expression of vascular endothelial growth factor and interleukin-8.	cepharanthine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	167-180
19720161-7	2009	On the contrary, 5-methoxypsoralen resulted in IL-8 inhibition at 10 microM concentration, without effects on cell proliferation.	5-Methoxypsoralen	17-34	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
20067543-2	2009	Here we demonstrate that tumour-derived prostaglandin E2 (PGE(2)) and transforming growth factor-beta (TGF-beta) increase interleukin-8 (IL-8) but synergistically inhibit interferon-alpha (IFN-alpha) and tumour necrosis factor (TNF) production of Toll-like receptor 7 (TLR7)- and Toll-like receptor 9 (TLR9)-stimulated PDC.	Dinoprostone	40-56	C-X-C motif chemokine ligand 8	Homo sapiens	122-135
20067543-2	2009	Here we demonstrate that tumour-derived prostaglandin E2 (PGE(2)) and transforming growth factor-beta (TGF-beta) increase interleukin-8 (IL-8) but synergistically inhibit interferon-alpha (IFN-alpha) and tumour necrosis factor (TNF) production of Toll-like receptor 7 (TLR7)- and Toll-like receptor 9 (TLR9)-stimulated PDC.	Dinoprostone	40-56	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
20067543-2	2009	Here we demonstrate that tumour-derived prostaglandin E2 (PGE(2)) and transforming growth factor-beta (TGF-beta) increase interleukin-8 (IL-8) but synergistically inhibit interferon-alpha (IFN-alpha) and tumour necrosis factor (TNF) production of Toll-like receptor 7 (TLR7)- and Toll-like receptor 9 (TLR9)-stimulated PDC.	Prostaglandins E	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	122-135
20067543-2	2009	Here we demonstrate that tumour-derived prostaglandin E2 (PGE(2)) and transforming growth factor-beta (TGF-beta) increase interleukin-8 (IL-8) but synergistically inhibit interferon-alpha (IFN-alpha) and tumour necrosis factor (TNF) production of Toll-like receptor 7 (TLR7)- and Toll-like receptor 9 (TLR9)-stimulated PDC.	Prostaglandins E	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
19787256-7	2009	These findings suggest that Cepharanthine can suppress angiogenesis and growth of OSCC cells by inhibiting expression of VEGF and IL-8 involved in the blockade of NF-kappaB activity.	cepharanthine	28-41	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
20134045-7	2009	Inhibition of NF-kappaB with curcumin or parthenolide resulted in a decrease of IL-8 secretion.	Curcumin	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
19726162-0	2009	Nicotinamide inhibits Propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-kappaB and MAPK pathways.	Niacinamide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
19726162-7	2009	A luciferase reporter system assay was used to assess nicotinamide activity with the IL-8 promoter in transfected keratinocytes.	Niacinamide	54-66	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
19726162-9	2009	RESULTS: Nicotinamide significantly decreased IL-8 production in a dose-dependent manner, decreasing both mRNA and protein levels for this chemokine in immortalized HaCaT cells and primary keratinocytes.	Niacinamide	9-21	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
19726162-10	2009	P. acnes-induced IL-8 promoter activation seemed to be downregulated by nicotinamide, which inhibited IkappaB degradation and the phosphorylation of ERK and JNK MAP kinases.	Niacinamide	72-84	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
19726162-11	2009	CONCLUSION: Our results indicate that nicotinamide inhibits IL-8 production through the NF-kappaB and MAPK pathways in an in vitro keratinocytes/P.	Niacinamide	38-50	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
20134045-7	2009	Inhibition of NF-kappaB with curcumin or parthenolide resulted in a decrease of IL-8 secretion.	parthenolide	41-53	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
19525101-7	2009	RESULTS: Dexamethasone enhanced the phagocytic capacity of A549 cells and inhibited the production of IL-6 and IL-8 from A549 cells stimulated by LPS.	Dexamethasone	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
19668110-9	2009	In PBMO, interaction with autologous apoptotic neutrophils reduced LPS-induced IL-8 production whereas it was enhanced in CBMO.	pbmo	3-7	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
19525101-8	2009	Interestingly, aminophylline and terbutaline could not only down-regulate the ingestion of apoptotic eosinophils by A549 cells in a time- and dose-dependent manner, but also decrease IL-6 and IL-8 secretion by A549 cells induced by LPS.	Aminophylline	15-28	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
19525101-8	2009	Interestingly, aminophylline and terbutaline could not only down-regulate the ingestion of apoptotic eosinophils by A549 cells in a time- and dose-dependent manner, but also decrease IL-6 and IL-8 secretion by A549 cells induced by LPS.	Terbutaline	33-44	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
19713110-1	2009	We describe herein a novel series of 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective inhibitors against the CXCR2 chemokine receptor and IL-8-mediated chemotaxis of a CXCR2-expressing cell line.	3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones	37-82	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
19525101-9	2009	CONCLUSIONS: The present study showed that all of the investigated anti-asthmatic drugs including dexamethasone, aminophylline and terbutaline play an anti-inflammatory effect by decreasing the release of IL-6 and IL-8 induced by LPS.	Dexamethasone	98-111	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
19525101-9	2009	CONCLUSIONS: The present study showed that all of the investigated anti-asthmatic drugs including dexamethasone, aminophylline and terbutaline play an anti-inflammatory effect by decreasing the release of IL-6 and IL-8 induced by LPS.	Aminophylline	113-126	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
19525101-9	2009	CONCLUSIONS: The present study showed that all of the investigated anti-asthmatic drugs including dexamethasone, aminophylline and terbutaline play an anti-inflammatory effect by decreasing the release of IL-6 and IL-8 induced by LPS.	Terbutaline	131-142	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
19845437-5	2009	The serum half-life was estimated as being between 2 and 4 h. Prednisolone exhibits near complete inhibition of the cytokines TNF-alpha, IL-1beta, IL-6 and IL-8 with very similar IC50 estimates from 0.09 to 0.16 microg ml(-1) (from 0.24 to 0.44 microM).	Prednisolone	62-74	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
19607809-3	2009	Both OA-NO(2) and LNO(2) prevented TNFalpha-stimulated release of the cytokines, IL-6, IL-8, IL-12/p40, IFNgamma, MCP-1, and IP-10, and inhibited NF-kappaB activation.	L-Leucyl-Hydroxylamine	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
19846942-6	2009	Doxycycline (5 microg/ml) below the cytotoxic level suppressed endogenous and paclitaxel-induced IL-8 expression.	Paclitaxel	78-88	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
19577291-6	2009	After 6 and 18 h of incubation HA and beta-TCP caused a quite similar induction of TNF-alpha, IL-1beta and IL-8.	beta-tricalcium phosphate	38-46	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
19887723-2	2009	The aim of this study was to determine the effect of low level sodium fluoride (NaF) on the proliferation and migration of epithelial cells in vitro.	Sodium Fluoride	63-78	C-X-C motif chemokine ligand 8	Homo sapiens	80-83
19887723-7	2009	Quantitative real-time PCR revealed that low concentration of NaF up-regulated fibronectin mRNA expression in fluoride-treated cells compared with controls.	Fluorides	110-118	C-X-C motif chemokine ligand 8	Homo sapiens	62-65
19847291-9	2009	This was concomitant with increased IL-8 synthesis and cPLA2alpha activation, ultimately resulting in eicosanoid (PGE2 and LTB4) overproduction.	Eicosanoids	102-112	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
19847291-9	2009	This was concomitant with increased IL-8 synthesis and cPLA2alpha activation, ultimately resulting in eicosanoid (PGE2 and LTB4) overproduction.	Dinoprostone	114-118	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
19847291-10	2009	DRM destabilizing agent methyl-beta-cyclodextrin induced further cPLA2alpha activation and eicosanoid release, but inhibited IL-8 synthesis.	methyl-beta-cyclodextrin	24-48	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
19835594-8	2009	While cells pre-treated with cytokines alone exhibited significantly enhanced IL-8 and CCL20 secretion following Pam3CSK4, mean IL-8 and CCL20 release decreased in Pam3CSK4 stimulated cells following cytokines + dex pre-treatment.	Dexamethasone	212-215	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
19846942-3	2009	We also investigated the effect of doxycycline on expression of a potent proangiogenic factor, interleukin (IL)-8.	Doxycycline	35-46	C-X-C motif chemokine ligand 8	Homo sapiens	95-113
19846942-6	2009	Doxycycline (5 microg/ml) below the cytotoxic level suppressed endogenous and paclitaxel-induced IL-8 expression.	Doxycycline	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
19846942-8	2009	CONCLUSION: These data suggest that doxycycline exerts its antitumor effect by activating proapoptotic genes, inhibiting IL-8 expression, and suppressing antiapoptotic genes.	Doxycycline	36-47	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
19632157-5	2009	We also show that RA patients produced anti-IL-8 autoantibodies and that their levels dropped after RTX treatment.	resiniferatoxin	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
19632157-6	2009	Moreover, we identified antibody-IL-8 immune complexes in the synovial fluid and serum of RA patients, and found that the amount of these complexes decreased after the administration of RTX.	resiniferatoxin	186-189	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
19654006-9	2009	Treatment of neutrophils with apyrase (catalyses the hydrolysis of ATP to yield AMP) and suramin (P2-receptor antagonist) abrogated the release of CXCL8 and elastase induced by cigarette smoke extract and exogenous ATP.	Adenosine Triphosphate	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	147-152
19654006-9	2009	Treatment of neutrophils with apyrase (catalyses the hydrolysis of ATP to yield AMP) and suramin (P2-receptor antagonist) abrogated the release of CXCL8 and elastase induced by cigarette smoke extract and exogenous ATP.	Adenosine Monophosphate	80-83	C-X-C motif chemokine ligand 8	Homo sapiens	147-152
19735076-6	2009	In addition, IL-8 secretion was markedly diminished by the non-selective P2 receptor antagonists reactive blue 2 and suramin, and by a selective P2Y(6) antagonist, MRS2578.	Cibacron Blue F 3GA	97-112	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
19654006-9	2009	Treatment of neutrophils with apyrase (catalyses the hydrolysis of ATP to yield AMP) and suramin (P2-receptor antagonist) abrogated the release of CXCL8 and elastase induced by cigarette smoke extract and exogenous ATP.	Suramin	89-96	C-X-C motif chemokine ligand 8	Homo sapiens	147-152
19735076-6	2009	In addition, IL-8 secretion was markedly diminished by the non-selective P2 receptor antagonists reactive blue 2 and suramin, and by a selective P2Y(6) antagonist, MRS2578.	Suramin	117-124	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
19654006-9	2009	Treatment of neutrophils with apyrase (catalyses the hydrolysis of ATP to yield AMP) and suramin (P2-receptor antagonist) abrogated the release of CXCL8 and elastase induced by cigarette smoke extract and exogenous ATP.	Adenosine Triphosphate	215-218	C-X-C motif chemokine ligand 8	Homo sapiens	147-152
19589946-5	2009	CD clinical activity correlates directly with B cell expression of IL-8 and TLR2, suggesting a positive relationship between these B cell inflammatory mediators and disease pathogenesis.	Cadmium	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
20074471-3	2009	The aim of this study is to investigate whether tetrabromofluorecin, commonly know as eosin, a classical compound traditionally topically used in psoriasis for its presumed anti-inflammatory activities, is able to modulate the production of TNF-alpha, IL-6 and IL-8 that are recognized as the most active and characterized cytokines in the pathogenesis of this skin disorder.	tetrabromofluorecin	48-67	C-X-C motif chemokine ligand 8	Homo sapiens	261-265
20074471-3	2009	The aim of this study is to investigate whether tetrabromofluorecin, commonly know as eosin, a classical compound traditionally topically used in psoriasis for its presumed anti-inflammatory activities, is able to modulate the production of TNF-alpha, IL-6 and IL-8 that are recognized as the most active and characterized cytokines in the pathogenesis of this skin disorder.	Eosine Yellowish-(YS)	86-91	C-X-C motif chemokine ligand 8	Homo sapiens	261-265
20074471-8	2009	The expression and production of TNFalpha, IL-8 and IL-6 were dramatically reduced in presence of eosin 0.05% and 0.02% and the action of eosin was more pronounced on TNF-alpha.	Eosine Yellowish-(YS)	98-103	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
19362013-14	2009	The PV/PA ratio of interleukin-8 and interleukin-10 increased after the restoration of the pulmonary circulation in the sufentanil group but decreased in the sevoflurane group.	Sufentanil	120-130	C-X-C motif chemokine ligand 8	Homo sapiens	19-32
19362013-14	2009	The PV/PA ratio of interleukin-8 and interleukin-10 increased after the restoration of the pulmonary circulation in the sufentanil group but decreased in the sevoflurane group.	Sevoflurane	158-169	C-X-C motif chemokine ligand 8	Homo sapiens	19-32
19740380-9	2009	Superoxide release from neutrophils was measured by the reduction of ferricytochrome C, degranulation by the conversion of a synthetic colour substrate, cytokine release by interleukin-8 enzyme-linked immunosorbent assay, and adhesion by a flow-based adhesion assay.	Superoxides	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	173-186
19626664-0	2009	Glucosamine inhibits IL-1beta-mediated IL-8 production in prostate cancer cells by MAPK attenuation.	Glucosamine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
19626664-4	2009	Glucosamine is widely regarded as an anti-inflammatory agent and thus we hypothesized that if IL-1beta activated IL-8 production in prostate cancer cells, then glucosamine ought to blunt such an effect.	Glucosamine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
19626664-5	2009	Three prostate cancer cell lines, DU-145, PC-3, and LNCaP, were used to evaluate the effects of IL-1beta and glucosamine on IL-8 expression using ELISA and RT-PCR analyses.	Glucosamine	109-120	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
19626664-7	2009	Glucosamine significantly inhibited IL-1beta-induced IL-8 secretion.	Glucosamine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
19626664-8	2009	IL-8 appeared to induce LNCaP cell proliferation by MTT assay; involvement of IL-8 in IL-1beta-dependent PC-3 cell migration was demonstrated by wound-healing and transwell migration assays.	monooxyethylene trimethylolpropane tristearate	52-55	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19626664-12	2009	In this context, glucosamine appears to inhibit IL-1beta-mediated activation of MAPKs and therefore reduces IL-8 production; this, in turn, attenuates cell proliferation/migration.	Glucosamine	17-28	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
19745762-10	2009	Gangliosides suppressed infant bowel production of nitric oxide, leukotriene B4, prostaglandin E2, hydrogen peroxide, interleukin-1beta, interleukin-6, and interleukin-8 in response to LPS exposure and hypoxia.	Gangliosides	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	156-169
19699525-11	2009	Interestingly, IL-8 mRNA was induced by cycloheximide treatment and RANTES showed reduced mRNA but increased protein expression by antibody stimulation.	Cycloheximide	40-53	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
19732956-9	2009	In patients treated with methotrexate for active inflammatory arthritis, a reduction in NR4A2 synovial tissue levels correlate significantly (n=10, r=0.73, p=0.002) with changes in IL-8 expression.	Methotrexate	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
19555716-11	2009	Macrolides have shown great promise in their ability to reduce airway inflammation, and can reduce airway neutrophils, levels of CXCL8 and neutrophil proteases in the airways.	Macrolides	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	129-134
19794965-0	2009	A(2B) and A(3) adenosine receptors modulate vascular endothelial growth factor and interleukin-8 expression in human melanoma cells treated with etoposide and doxorubicin.	Etoposide	145-154	C-X-C motif chemokine ligand 8	Homo sapiens	83-96
19794965-0	2009	A(2B) and A(3) adenosine receptors modulate vascular endothelial growth factor and interleukin-8 expression in human melanoma cells treated with etoposide and doxorubicin.	Doxorubicin	159-170	C-X-C motif chemokine ligand 8	Homo sapiens	83-96
19794965-5	2009	We have examined whether the DNA-damaging agents etoposide (VP-16) and doxorubicin can affect IL-8, VEGF, and HIF-1 expressions in human melanoma cancer cells.	Etoposide	49-58	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
19794965-5	2009	We have examined whether the DNA-damaging agents etoposide (VP-16) and doxorubicin can affect IL-8, VEGF, and HIF-1 expressions in human melanoma cancer cells.	Etoposide	60-65	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
19794965-5	2009	We have examined whether the DNA-damaging agents etoposide (VP-16) and doxorubicin can affect IL-8, VEGF, and HIF-1 expressions in human melanoma cancer cells.	Doxorubicin	71-82	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
19788733-3	2009	Here we study the role of the cyclic AMP (cAMP) effectors protein kinase A (PKA) and exchange proteins directly activated by cAMP (Epac1 and Epac2) in the bradykinin-induced IL-8 release from a human airway smooth muscle cell line and the underlying molecular mechanisms of this response.	Cyclic AMP	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
19591856-0	2009	HuR/ELAVL1 RNA binding protein modulates interleukin-8 induction by muco-active ribotoxin deoxynivalenol.	deoxynivalenol	90-104	C-X-C motif chemokine ligand 8	Homo sapiens	41-54
19591856-3	2009	We investigated the effects of ribotoxin deoxynivalenol (DON) on HuR translocation and its involvement in the regulation of the pro-inflammatory interleukin-8 (IL-8) mRNA stability.	deoxynivalenol	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	145-158
19591856-3	2009	We investigated the effects of ribotoxin deoxynivalenol (DON) on HuR translocation and its involvement in the regulation of the pro-inflammatory interleukin-8 (IL-8) mRNA stability.	deoxynivalenol	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
19591856-5	2009	Moreover, the interference with HuR protein production suppressed ribotoxic DON-induced IL-8 secretion and its mRNA stability.	deoxynivalenol	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
19591856-7	2009	Partly in terms of IL-8-modulating transcription factors, HuR protein was demonstrated to be positively and negatively associated with DON-induced early growth response gene 1 (EGR-1) and activating transcription factor 3 (ATF3), respectively.	deoxynivalenol	135-138	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
19788733-16	2009	Treatment of the cells with toxin B-1470 and U0126 significantly reduced bradykinin-induced IL-8 release alone or in combination with the activators of PKA and Epac.	Boron	34-35	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
19788733-16	2009	Treatment of the cells with toxin B-1470 and U0126 significantly reduced bradykinin-induced IL-8 release alone or in combination with the activators of PKA and Epac.	U 0126	45-50	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
19788733-3	2009	Here we study the role of the cyclic AMP (cAMP) effectors protein kinase A (PKA) and exchange proteins directly activated by cAMP (Epac1 and Epac2) in the bradykinin-induced IL-8 release from a human airway smooth muscle cell line and the underlying molecular mechanisms of this response.	Cyclic AMP	42-46	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
19788749-8	2009	RESULTS: The spontaneous IL-8 and GM-CSF release was significantly reduced with MXF (8 mg/l) by 37 +/- 20% and 45 +/- 31%, respectively (both p &lt; 0.01).	Moxifloxacin	80-83	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
19788733-3	2009	Here we study the role of the cyclic AMP (cAMP) effectors protein kinase A (PKA) and exchange proteins directly activated by cAMP (Epac1 and Epac2) in the bradykinin-induced IL-8 release from a human airway smooth muscle cell line and the underlying molecular mechanisms of this response.	Cyclic AMP	125-129	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
19788749-9	2009	IL-8 release in TNF-alpha stimulated hu-BEC decreased by 16 +/- 8% (p &lt; 0.05) with AZM (1.5 mg/l).	Azithromycin	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19788733-4	2009	METHODS: IL-8 release was assessed via ELISA under basal condition and after stimulation with bradykinin alone or in combination with fenoterol, the Epac activators 8-pCPT-2"-O-Me-cAMP and Sp-8-pCPT-2"-O-Me-cAMPS, the PKA activator 6-Bnz-cAMP and the cGMP analog 8-pCPT-2"-O-Me-cGMP.	Fenoterol	134-143	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
19788733-4	2009	METHODS: IL-8 release was assessed via ELISA under basal condition and after stimulation with bradykinin alone or in combination with fenoterol, the Epac activators 8-pCPT-2"-O-Me-cAMP and Sp-8-pCPT-2"-O-Me-cAMPS, the PKA activator 6-Bnz-cAMP and the cGMP analog 8-pCPT-2"-O-Me-cGMP.	8-pCPT-2'-O-Me-cAMP	165-184	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
19788733-4	2009	METHODS: IL-8 release was assessed via ELISA under basal condition and after stimulation with bradykinin alone or in combination with fenoterol, the Epac activators 8-pCPT-2"-O-Me-cAMP and Sp-8-pCPT-2"-O-Me-cAMPS, the PKA activator 6-Bnz-cAMP and the cGMP analog 8-pCPT-2"-O-Me-cGMP.	sp-8-pcpt-2"-o-me-camps	189-212	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
19648110-4	2009	Since NF-kappaB-dependent transcription and IL-8 protein, mRNA, and unspliced RNA (a surrogate of transcription rate) are sensitive to p38 MAPK inhibitors (SB203580 and SB239063), we explored the role of MKP-1 in repression of these outputs.	SB 203580	156-164	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
19788733-4	2009	METHODS: IL-8 release was assessed via ELISA under basal condition and after stimulation with bradykinin alone or in combination with fenoterol, the Epac activators 8-pCPT-2"-O-Me-cAMP and Sp-8-pCPT-2"-O-Me-cAMPS, the PKA activator 6-Bnz-cAMP and the cGMP analog 8-pCPT-2"-O-Me-cGMP.	Bz-Camp	232-242	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
19648110-4	2009	Since NF-kappaB-dependent transcription and IL-8 protein, mRNA, and unspliced RNA (a surrogate of transcription rate) are sensitive to p38 MAPK inhibitors (SB203580 and SB239063), we explored the role of MKP-1 in repression of these outputs.	SB 239063	169-177	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
19648110-5	2009	Repression of TNFalpha-induced p38 MAPK phosphorylation, NF-kappaB-dependent transcription, and IL-8 expression by dexamethasone are sensitive to transcriptional or translational inhibitors.	Dexamethasone	115-128	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
19788733-4	2009	METHODS: IL-8 release was assessed via ELISA under basal condition and after stimulation with bradykinin alone or in combination with fenoterol, the Epac activators 8-pCPT-2"-O-Me-cAMP and Sp-8-pCPT-2"-O-Me-cAMPS, the PKA activator 6-Bnz-cAMP and the cGMP analog 8-pCPT-2"-O-Me-cGMP.	Cyclic GMP	251-255	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
19788733-4	2009	METHODS: IL-8 release was assessed via ELISA under basal condition and after stimulation with bradykinin alone or in combination with fenoterol, the Epac activators 8-pCPT-2"-O-Me-cAMP and Sp-8-pCPT-2"-O-Me-cAMPS, the PKA activator 6-Bnz-cAMP and the cGMP analog 8-pCPT-2"-O-Me-cGMP.	8-pcpt-2"-o-me-cgmp	263-282	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
19788733-11	2009	RESULTS: The beta2-agonist fenoterol augmented release of IL-8 by bradykinin.	Fenoterol	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
19788733-12	2009	The PKA activator 6-Bnz-cAMP and the Epac activator 8-pCPT-2"-O-Me-cAMP significantly increased bradykinin-induced IL-8 release.	Bz-Camp	18-28	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
19788733-12	2009	The PKA activator 6-Bnz-cAMP and the Epac activator 8-pCPT-2"-O-Me-cAMP significantly increased bradykinin-induced IL-8 release.	8-pcpt-2"-o-me	52-66	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
19788733-12	2009	The PKA activator 6-Bnz-cAMP and the Epac activator 8-pCPT-2"-O-Me-cAMP significantly increased bradykinin-induced IL-8 release.	Cyclic AMP	24-28	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
19372002-8	2009	However, such an acceleration is markedly suppressed by introducing NaF into the reaction system since NaF forms a complex with Fe(III).	ferric sulfate	128-135	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
19372002-8	2009	However, such an acceleration is markedly suppressed by introducing NaF into the reaction system since NaF forms a complex with Fe(III).	ferric sulfate	128-135	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
19422399-4	2009	KEY RESULTS: In equilibrium saturation binding studies, SB265610 depressed the maximal binding of [(125)I]-interleukin-8 ([(125)I]-IL-8) without affecting the K(d).	1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	107-120
19647751-3	2009	KEY FINDINGS: We showed that gAd induces the expression of a number of genes using PCR arrays, including MCP-1, VCAM-1, E-selectin, IL-6, and IL-8, all of which have been previously shown to be associated with adiponectin, as well as SOD2, PAI-1, and CSF2, which is a new finding.	ganoderic acid D	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
19753313-9	2009	Treatment with 100 microg/ml cis-UCA completely suppressed IL-6 and IL-8 secretion, decreased caspase-3 activity, and improved cell viability against UV-B irradiation.	cis-Urocanic acid	29-36	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
19422399-4	2009	KEY RESULTS: In equilibrium saturation binding studies, SB265610 depressed the maximal binding of [(125)I]-interleukin-8 ([(125)I]-IL-8) without affecting the K(d).	1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
19422399-7	2009	In functional experiments, SB265610 caused a rightward shift of the concentration-response curves to IL-8 and growth-related oncogene alpha, but also a reduction in maximal response elicited by each agonist.	1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	101-139
19839871-8	2009	The result of ELISA also showed the release of IL-6 and IL-8 can be inhibited by hydrocortisone.	Hydrocortisone	81-95	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
19941760-8	2009	Conversely, the adhesive resin and formocresol stimulated the production of IL-8, and did not stimulate IL-l beta.	formocresol	35-46	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
19694614-5	2009	In vitro studies using phorbol 12-myristyl 13-acetate (PMA) stimulated macrophage-like THP-1 (mTHP-1) cells were focused on cytotoxicity of both polymers and particles, and their potential to stimulate IL-8 release via the TLR-2 pathway.	phorbol 12-myristyl 13-acetate	23-53	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
19694614-5	2009	In vitro studies using phorbol 12-myristyl 13-acetate (PMA) stimulated macrophage-like THP-1 (mTHP-1) cells were focused on cytotoxicity of both polymers and particles, and their potential to stimulate IL-8 release via the TLR-2 pathway.	Tetradecanoylphorbol Acetate	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
19740321-9	2009	Poly(I:C) induced a small increase in IL-1beta, IL-6 and IL-8 production in HNECs, while Pam(3)CSK(4) increased viability.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
19450704-5	2009	Treating HeLa cells with the calcium chelator BAPTA-AM or with D-BAPTA-AM, a derivative with greatly reduced Ca(2+) chelating activity, yielded strong evidence that BAPTA-AM does not affect invasion and inhibits IL-8 secretion by a calcium-dependent mechanism.	d-bapta-am	63-73	C-X-C motif chemokine ligand 8	Homo sapiens	212-216
19928254-1	2009	In the present work, aligned TiO2 nanotubes have been synthesized by a simple method of electrochemical anodization of high purity, well cleaned, etched and ultrasonicated Ti-sheet (Purity approximately 99.99%) in a fluoride mediated electrolytic media consisting of a solution of 0.14 M NaF and a solution of 0.5 M/1.0 M H3PO4.	titanium dioxide	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	288-291
19500686-0	2009	Norepinephrine-dependently released Dr fimbriae of diffusely adhering Escherichia coli strain IH11128 promotes a mitogen-activated protein kinase ERK1/2-dependent production of pro-inflammatory cytokine, IL-8 in human intestinal Caco-2/TC7 cells.	Norepinephrine	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
19740260-9	2009	Significant results in univariate and multivariate analysis of the association between biomarkers and BODE components were: serum MCP-1 correlated with FEV(1)% and 6MWD; serum IL-8 and GRO-alpha correlated with steroid use; serum TNF-alpha correlated with steroid use and FEV(1)%; and serum MMP-9 correlated with MMRC dyspnoea scale.	Steroids	211-218	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
19703242-9	2009	In conclusion, L. reuteri RC-14 alone and together with L. rhamnosus GR-1 have the potential to inhibit the yeast growth and their CFS may up-regulate IL-8 and IP-10 secretion by VK2/E6E7 cells, which could possibly have played an important role in helping to clear VVC in vivo.	1,1-dichloro-1-fluoroethane	26-31	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
19668862-7	2009	Reporter systems with segments of the IL-8 promoter showed a specific activation in response to hm-sulfated polysaccharides with lower pathophysiological potential in vivo and provided a better classification of CGN-variants than cytotoxicity assays in vitro.	Polysaccharides	108-123	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
19668862-8	2009	IL-8 reporter systems can be used for discerning between the effects of sulfated polysaccharides in vivo.	Polysaccharides	81-96	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19564644-7	2009	Medroxyprogesterone acetate significantly suppressed LPS-induced production of interleukin 1b (IL-1b), IL-6, and IL-8 in vitro (P &lt; .05).	Medroxyprogesterone Acetate	0-27	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
19781372-8	2009	In addition, preincubation of EPCs with SB203580, an inhibitor of p38 mitogen-activated protein kinase (MAPK) decreased CRP inhibition of IL-8 mRNA expression at 12 hours in EPCs.	SB 203580	40-48	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
19651324-12	2009	Additionally, SM upregulates many inflammatory mediators including interleukin (IL)-1alpha, IL-1beta, IL-6, IL-8, tumor necrosis factor-alpha (TNF-alpha) and others.	Mustard Gas	14-16	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
19709445-11	2009	The IL-8 induced-IL-8 mRNA expression was inhibited by PD98059 (a MEK inhibitor) or SB203580 (a p38 MAPK inhibitor).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	55-62	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
19709445-11	2009	The IL-8 induced-IL-8 mRNA expression was inhibited by PD98059 (a MEK inhibitor) or SB203580 (a p38 MAPK inhibitor).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	55-62	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
19709445-11	2009	The IL-8 induced-IL-8 mRNA expression was inhibited by PD98059 (a MEK inhibitor) or SB203580 (a p38 MAPK inhibitor).	SB 203580	84-92	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
19709445-11	2009	The IL-8 induced-IL-8 mRNA expression was inhibited by PD98059 (a MEK inhibitor) or SB203580 (a p38 MAPK inhibitor).	SB 203580	84-92	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
19709445-13	2009	The inhibitory effect of IL-8 was eliminated by either PD 98059 or SB203580.	SB 203580	67-75	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
19540326-0	2009	Tetramethylpyrazine suppresses interleukin-8 expression in LPS-stimulated human umbilical vein endothelial cell by blocking ERK, p38 and nulear factor-kappaB signaling pathways.	tetramethylpyrazine	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	31-44
19540326-1	2009	AIM OF THE STUDY: To determine the anti-inflammatory effects of Tetramethylpyrazine (TMP) and to investigate the inhibitory effect of TMP on IL-8 production in human umbilical vein endothelial cells (HUVECs) induced by LPS might be mediated by inhibiting p38, ERK and NF-kappaB signaling pathways.	tetramethylpyrazine	134-137	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
19540326-6	2009	RESULTS: TMP inhibits LPS-induced IL-8 production in HUVECs at both the protein and mRNA levels, suggesting that TMP has an antiinflammatory effect on endothelial cells.	tetramethylpyrazine	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
19540326-6	2009	RESULTS: TMP inhibits LPS-induced IL-8 production in HUVECs at both the protein and mRNA levels, suggesting that TMP has an antiinflammatory effect on endothelial cells.	tetramethylpyrazine	113-116	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
19540326-10	2009	CONCLUSIONS: The inhibitory effect of TMP on the LPS-induced IL-8 production is mediated by the NF-kappaB-dependent pathway, and TMP also separately affects the ERK and p38 MAPK pathway.	tetramethylpyrazine	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
19691415-3	2009	In the present work, we perform simulations on proteins Naf-BBL, QNND-BBL, CI2, and SH3 with the Go model and compare their different folding behaviors.	N-Carbobenzyloxy-L-alanine	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
19635923-5	2009	In Boyden chamber assays, alphabetaMeATP provoked chemokinesis and enhanced formylated peptide- and IL-8-induced chemotaxis of human neutrophils.	alpha,beta-methyleneadenosine 5'-triphosphate	26-40	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
19376214-4	2009	NaF-induced accumulation of COX-2 transcript was abolished by actinomycin D, but not cycloheximide.	Dactinomycin	62-75	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
19376214-4	2009	NaF-induced accumulation of COX-2 transcript was abolished by actinomycin D, but not cycloheximide.	Cycloheximide	85-98	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
19376214-5	2009	The level of prostaglandin E(2), a major product of COX enzymes, increased in response to NaF exposure, and its production was abolished by the selective COX-2 inhibitor NS-398.	Dinoprostone	13-31	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
19376214-5	2009	The level of prostaglandin E(2), a major product of COX enzymes, increased in response to NaF exposure, and its production was abolished by the selective COX-2 inhibitor NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	170-176	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
19376214-6	2009	Phosphorylated forms of mitogen-activated protein kinases (MAPKs)-including extracellular signal-regulated protein kinase (ERK), c-Jun NH(2)-terminal kinase, and p38-increased after NaF exposure, while treatment with the MAPK/ERK kinase inhibitor U0126 and the p38 inhibitor SB203580 markedly suppressed COX-2 expression.	U 0126	247-252	C-X-C motif chemokine ligand 8	Homo sapiens	182-185
19376214-6	2009	Phosphorylated forms of mitogen-activated protein kinases (MAPKs)-including extracellular signal-regulated protein kinase (ERK), c-Jun NH(2)-terminal kinase, and p38-increased after NaF exposure, while treatment with the MAPK/ERK kinase inhibitor U0126 and the p38 inhibitor SB203580 markedly suppressed COX-2 expression.	SB 203580	275-283	C-X-C motif chemokine ligand 8	Homo sapiens	182-185
19376214-7	2009	Furthermore, NaF-induced COX-2 expression was markedly suppressed by the Src family kinase (SFK) inhibitor PP2, but only partially suppressed by the epidermal growth factor receptor (EGFR) inhibitor PD153035.	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	199-207	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
19578117-4	2009	On the other hand, loop 2 of IL-8 closely resembles a surface-exposed sequence of the VWF propeptide, the region of VWF that directs sorting of the protein to WPB.	propeptide	90-100	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
19558546-7	2009	KEY RESULTS: BGMP up-regulated the secretion of TNF, IL-1beta and IL-8 in a concentration-dependent fashion.	bgmp	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
19525388-10	2009	Ox-AT generated in the airway interacts directly with epithelial cells to release chemokines IL-8 and MCP-1, which in turn attracts macrophages and neutrophils into the airways.	ox-at	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
19349075-6	2009	NHBC responded to PE particles by increasing the mRNA expression of several genes associated with osteoclast formation and activity (RANKL, IL-8 and M-CSF) and decreased the expression of the osteoclast antagonist, OPG.	Polyethylene	18-20	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
19558546-9	2009	The secretion of IL-8 and specially TNF and IL-1beta was blocked by PD98059, SP600125, SB203580 and Bay11-7082, suggesting the involvement of the MAP kinases p38, c-Jun N-terminal kinase and ERK and particularly the NF-kappaB pathway, although IL-8 secretion was independent of p38.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	68-75	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
19558546-9	2009	The secretion of IL-8 and specially TNF and IL-1beta was blocked by PD98059, SP600125, SB203580 and Bay11-7082, suggesting the involvement of the MAP kinases p38, c-Jun N-terminal kinase and ERK and particularly the NF-kappaB pathway, although IL-8 secretion was independent of p38.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	68-75	C-X-C motif chemokine ligand 8	Homo sapiens	244-248
19558546-9	2009	The secretion of IL-8 and specially TNF and IL-1beta was blocked by PD98059, SP600125, SB203580 and Bay11-7082, suggesting the involvement of the MAP kinases p38, c-Jun N-terminal kinase and ERK and particularly the NF-kappaB pathway, although IL-8 secretion was independent of p38.	pyrazolanthrone	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
19558546-9	2009	The secretion of IL-8 and specially TNF and IL-1beta was blocked by PD98059, SP600125, SB203580 and Bay11-7082, suggesting the involvement of the MAP kinases p38, c-Jun N-terminal kinase and ERK and particularly the NF-kappaB pathway, although IL-8 secretion was independent of p38.	pyrazolanthrone	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	244-248
19558546-9	2009	The secretion of IL-8 and specially TNF and IL-1beta was blocked by PD98059, SP600125, SB203580 and Bay11-7082, suggesting the involvement of the MAP kinases p38, c-Jun N-terminal kinase and ERK and particularly the NF-kappaB pathway, although IL-8 secretion was independent of p38.	SB 203580	87-95	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
19558546-9	2009	The secretion of IL-8 and specially TNF and IL-1beta was blocked by PD98059, SP600125, SB203580 and Bay11-7082, suggesting the involvement of the MAP kinases p38, c-Jun N-terminal kinase and ERK and particularly the NF-kappaB pathway, although IL-8 secretion was independent of p38.	SB 203580	87-95	C-X-C motif chemokine ligand 8	Homo sapiens	244-248
19527294-5	2009	Treatment of bronchial epithelial cells with LL-37 and the TLR3 agonist polyI:C resulted in synergistic increases in IL-8 release and cytotoxicity.	Poly I-C	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
19622582-9	2009	AdEHCD40L induced apoptosis and S-phase cell cycle blockade while uniquely up-regulating the previously described proapoptotic elements tumor necrosis factor-related apoptosis-inducing ligand, Fas, and IL-8.	adehcd40l	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
19638548-5	2009	RESULTS: The mean glucose concentrations for NaF-KOx samples and Li-Heparin samples were 5.7 mmol/l and 6.1 mmol/l, respectively, with a mean difference of 0.39 mmol/l.	Glucose	18-25	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
19464389-4	2009	Hirsutenone attenuated the TNF-alpha-induced production of cytokine IL-8, prostaglandin E(2) and chemokine CCL27, and the formation of reactive oxygen/nitrogen species in keratinocytes.	hirsutenone	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
19464389-5	2009	Immunosuppressants (dexamethasone and cyclosporin A) inhibited the TNF-alpha-elicited formation of IL-8, prostaglandin E(2) and CCL27, but did not affect formation of reactive species.	Dexamethasone	20-33	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
19464389-5	2009	Immunosuppressants (dexamethasone and cyclosporin A) inhibited the TNF-alpha-elicited formation of IL-8, prostaglandin E(2) and CCL27, but did not affect formation of reactive species.	Cyclosporine	38-51	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
19842832-11	2009	These stimuli seem to activate mainly redox-sensitive transcription factors such as nuclear factor (NF)-kappa B and activator protein (AP)-1, both of which play a major role in the synthesis and secretion of chemotactic factors such as IL-8 and leukotriene B(4) (LTB(4)).	Leukotriene B4	245-258	C-X-C motif chemokine ligand 8	Homo sapiens	236-240
19507016-5	2009	In the transfection experiment, PD98059, a MEK1 inhibitor, decreased the transcription of IL-8 in a dose dependent pattern.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	32-39	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
19397752-9	2009	On day 5: IL-13, IL-7, IL-8 and MIP-1alpha concentrations were higher in dexamethasone-treated patients.	Dexamethasone	73-86	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
19649202-8	2009	Finally, PD0325901 inhibited the production of the proangiogenic factors vascular endothelial growth factor and interleukin 8 at a transcriptional level.	mirdametinib	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	112-125
19951500-6	2009	01); the level of IL-8 in sputum was significantly higher in severe asthmatics [2907.78 (331.67 - 3457.93) ng/L] than mild-moderate asthmatics [287.58 (130.75-656.84) ng/L] and healthy control subjects [179.2 (58.55-346.59) ng/L] (P &lt; 0.01); the percentages of neutrophilic apoptosis respectively cultured with LPS [(10.57 +/- 1.97)%], severe asthmatics supernatant [(11.82 +/- 2.96)%], IL-8 [(10.47 +/- 1.93)%], dexamethasone [(9.93 +/- 1.95)%], severe asthma supernatant + mifepristone [(12.15 +/- 2.86)%] in vitro were lower than that cultured with PBS [(17.98 +/- 2.27)%], healthy control supernatant [(17.37 +/- 2.50)%], mild-moderate asthmatics supernatant [(16.35 +/- 3.26)%], mifepristone [(17.89 +/- 2.38)%], and dexamethasone + mifepristone [(17.06 +/- 2.59)%] (P &lt; 0.01).	Dexamethasone	416-429	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
19400824-0	2009	Macrophage inflammatory protein-1beta and interleukin-8 associated with idiopathic steroid-sensitive nephrotic syndrome.	Steroids	83-90	C-X-C motif chemokine ligand 8	Homo sapiens	42-55
19646263-15	2009	Specifically, the cytotoxicity of Docetaxel, Staurosporine and Rapamycin increased significantly (&gt;40% at IC50 dose) in IL-8 depleted cells as compared to that in C-siRNA transfected cells.	Docetaxel	34-43	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
19646263-15	2009	Specifically, the cytotoxicity of Docetaxel, Staurosporine and Rapamycin increased significantly (&gt;40% at IC50 dose) in IL-8 depleted cells as compared to that in C-siRNA transfected cells.	Staurosporine	45-58	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
19646263-15	2009	Specifically, the cytotoxicity of Docetaxel, Staurosporine and Rapamycin increased significantly (&gt;40% at IC50 dose) in IL-8 depleted cells as compared to that in C-siRNA transfected cells.	Sirolimus	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
19951500-6	2009	01); the level of IL-8 in sputum was significantly higher in severe asthmatics [2907.78 (331.67 - 3457.93) ng/L] than mild-moderate asthmatics [287.58 (130.75-656.84) ng/L] and healthy control subjects [179.2 (58.55-346.59) ng/L] (P &lt; 0.01); the percentages of neutrophilic apoptosis respectively cultured with LPS [(10.57 +/- 1.97)%], severe asthmatics supernatant [(11.82 +/- 2.96)%], IL-8 [(10.47 +/- 1.93)%], dexamethasone [(9.93 +/- 1.95)%], severe asthma supernatant + mifepristone [(12.15 +/- 2.86)%] in vitro were lower than that cultured with PBS [(17.98 +/- 2.27)%], healthy control supernatant [(17.37 +/- 2.50)%], mild-moderate asthmatics supernatant [(16.35 +/- 3.26)%], mifepristone [(17.89 +/- 2.38)%], and dexamethasone + mifepristone [(17.06 +/- 2.59)%] (P &lt; 0.01).	Mifepristone	478-490	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
19951500-6	2009	01); the level of IL-8 in sputum was significantly higher in severe asthmatics [2907.78 (331.67 - 3457.93) ng/L] than mild-moderate asthmatics [287.58 (130.75-656.84) ng/L] and healthy control subjects [179.2 (58.55-346.59) ng/L] (P &lt; 0.01); the percentages of neutrophilic apoptosis respectively cultured with LPS [(10.57 +/- 1.97)%], severe asthmatics supernatant [(11.82 +/- 2.96)%], IL-8 [(10.47 +/- 1.93)%], dexamethasone [(9.93 +/- 1.95)%], severe asthma supernatant + mifepristone [(12.15 +/- 2.86)%] in vitro were lower than that cultured with PBS [(17.98 +/- 2.27)%], healthy control supernatant [(17.37 +/- 2.50)%], mild-moderate asthmatics supernatant [(16.35 +/- 3.26)%], mifepristone [(17.89 +/- 2.38)%], and dexamethasone + mifepristone [(17.06 +/- 2.59)%] (P &lt; 0.01).	Lead	555-558	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
19951500-6	2009	01); the level of IL-8 in sputum was significantly higher in severe asthmatics [2907.78 (331.67 - 3457.93) ng/L] than mild-moderate asthmatics [287.58 (130.75-656.84) ng/L] and healthy control subjects [179.2 (58.55-346.59) ng/L] (P &lt; 0.01); the percentages of neutrophilic apoptosis respectively cultured with LPS [(10.57 +/- 1.97)%], severe asthmatics supernatant [(11.82 +/- 2.96)%], IL-8 [(10.47 +/- 1.93)%], dexamethasone [(9.93 +/- 1.95)%], severe asthma supernatant + mifepristone [(12.15 +/- 2.86)%] in vitro were lower than that cultured with PBS [(17.98 +/- 2.27)%], healthy control supernatant [(17.37 +/- 2.50)%], mild-moderate asthmatics supernatant [(16.35 +/- 3.26)%], mifepristone [(17.89 +/- 2.38)%], and dexamethasone + mifepristone [(17.06 +/- 2.59)%] (P &lt; 0.01).	Mifepristone	687-699	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
19951500-6	2009	01); the level of IL-8 in sputum was significantly higher in severe asthmatics [2907.78 (331.67 - 3457.93) ng/L] than mild-moderate asthmatics [287.58 (130.75-656.84) ng/L] and healthy control subjects [179.2 (58.55-346.59) ng/L] (P &lt; 0.01); the percentages of neutrophilic apoptosis respectively cultured with LPS [(10.57 +/- 1.97)%], severe asthmatics supernatant [(11.82 +/- 2.96)%], IL-8 [(10.47 +/- 1.93)%], dexamethasone [(9.93 +/- 1.95)%], severe asthma supernatant + mifepristone [(12.15 +/- 2.86)%] in vitro were lower than that cultured with PBS [(17.98 +/- 2.27)%], healthy control supernatant [(17.37 +/- 2.50)%], mild-moderate asthmatics supernatant [(16.35 +/- 3.26)%], mifepristone [(17.89 +/- 2.38)%], and dexamethasone + mifepristone [(17.06 +/- 2.59)%] (P &lt; 0.01).	Dexamethasone	725-738	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
19951500-6	2009	01); the level of IL-8 in sputum was significantly higher in severe asthmatics [2907.78 (331.67 - 3457.93) ng/L] than mild-moderate asthmatics [287.58 (130.75-656.84) ng/L] and healthy control subjects [179.2 (58.55-346.59) ng/L] (P &lt; 0.01); the percentages of neutrophilic apoptosis respectively cultured with LPS [(10.57 +/- 1.97)%], severe asthmatics supernatant [(11.82 +/- 2.96)%], IL-8 [(10.47 +/- 1.93)%], dexamethasone [(9.93 +/- 1.95)%], severe asthma supernatant + mifepristone [(12.15 +/- 2.86)%] in vitro were lower than that cultured with PBS [(17.98 +/- 2.27)%], healthy control supernatant [(17.37 +/- 2.50)%], mild-moderate asthmatics supernatant [(16.35 +/- 3.26)%], mifepristone [(17.89 +/- 2.38)%], and dexamethasone + mifepristone [(17.06 +/- 2.59)%] (P &lt; 0.01).	Mifepristone	687-699	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
19661014-7	2009	AZM increased PgLPS-induced IL-8 production dose-dependently, while AZM did not alter IL-6 and PGE2 productions.	Azithromycin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
19661014-0	2009	Macrolide antibiotics like azithromycin increase lipopolysaccharide-induced IL-8 production by human gingival fibroblasts.	macrolide antibiotics	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
19623255-4	2009	At the same time, calcipotriol normalized the proinflammatory cytokine milieu and decreased interleukin (IL)-17A, IL-17F and IL-8 transcript abundance in lesional psoriatic skin.	calcipotriene	18-30	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
19661014-0	2009	Macrolide antibiotics like azithromycin increase lipopolysaccharide-induced IL-8 production by human gingival fibroblasts.	Azithromycin	27-39	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
19661014-7	2009	AZM increased PgLPS-induced IL-8 production dose-dependently, while AZM did not alter IL-6 and PGE2 productions.	pglps	14-19	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
19661014-11	2009	However, the use of the inhibitors of cell signaling pathway failed to reveal the mechanism that AZM enhanced PgLPS-induced IL-8 production.	Azithromycin	97-100	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
19661014-11	2009	However, the use of the inhibitors of cell signaling pathway failed to reveal the mechanism that AZM enhanced PgLPS-induced IL-8 production.	pglps	110-115	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
19661014-13	2009	Because AZM increased LPS-induced IL-8 production by HGFs, the possibility is considered that neutrophils may be migrated to periodontal tissue and phagocytize the periodontopathic bacteria more efficiently.	Azithromycin	8-11	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
19427879-5	2009	Inhibition experiments show that, at least for DNFB, p38 MAP kinase signalling controls compound-specific changes in CD54 expression and IL-8 release.	Dinitrofluorobenzene	47-51	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
19539545-2	2009	MSA is a potential in vivo metabolite of reparixin, a specific inhibitor of the CXCL8 biological activity.	methanesulfonamide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
19539545-2	2009	MSA is a potential in vivo metabolite of reparixin, a specific inhibitor of the CXCL8 biological activity.	reparixin	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
19450611-10	2009	Furthermore, when exposed to hypoxia for 48 h, the inhibitory effects of dexamethasone on LPS-stimulated IL-8 release were attenuated.	Dexamethasone	73-86	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
19450615-0	2009	Nanoparticles up-regulate tumor necrosis factor-alpha and CXCL8 via reactive oxygen species and mitogen-activated protein kinase activation.	Reactive Oxygen Species	68-91	C-X-C motif chemokine ligand 8	Homo sapiens	58-63
19450615-5	2009	Blockade of ROS generation with antioxidants significantly abrogated the QD-mediated TNF-alpha and CXCL8 expression in monocytes.	Reactive Oxygen Species	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	99-104
19450615-6	2009	The induced ROS generation subsequently led to the activation of MAPKs, which were crucial for mRNA and protein expression of TNF-alpha and CXCL8.	Reactive Oxygen Species	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	140-145
19324973-10	2009	These findings were corroborated and extended in experiments with cultured human bronchial epithelial cells in which ectoine inhibited nanoparticle-triggered cell signaling and IL-8 induction.	ectoine	117-124	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
19417127-6	2009	To verify whether muscular NF-kappaB activity in human subjects is suppressed by PPARgamma activation, we examined the effect of 8 wk of rosiglitazone treatment on muscular gene expression of ICAM-1 and IL-8 in type 2 diabetes mellitus patients.	Rosiglitazone	137-150	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
19594939-12	2009	The expression levels of IL-8, ICAM-1, IP-10, MCP-1, TNF-alpha and MMP-1 were significantly reduced after PC pre-treatment for at least two hours.	Phosphatidylcholines	106-108	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
19575800-1	2009	BACKGROUND: Previously we showed that reduced availability of the essential amino acid tryptophan per se attenuates post-transcriptional control of interleukin (IL)-6 and IL-8 leading to hyperresponsive production of these inflammatory mediators by airway epithelial cells.	essential amino acid tryptophan	66-97	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
19575800-2	2009	Availability of the non-essential amino acid arginine in the inflamed airway mucosa of patients with asthma is reduced markedly, but it is not known whether this can also lead to an exaggerated production of IL-6 and IL-8.	Arginine	45-53	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
19575800-7	2009	RESULTS: For both NCI-H292 and NHBE cells, low arginine concentrations enhanced basal epithelial IL-6 and IL-8 production and synergized with TNF-alpha-induced IL-6 and IL-8 production.	Arginine	47-55	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
19575800-7	2009	RESULTS: For both NCI-H292 and NHBE cells, low arginine concentrations enhanced basal epithelial IL-6 and IL-8 production and synergized with TNF-alpha-induced IL-6 and IL-8 production.	Arginine	47-55	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
19575800-8	2009	Poly-L-arginine enhanced the stimulus-induced IL-6 and IL-8 production, however, blocking arginine uptake and the enhanced IL-6 and IL-8 production appeared unrelated.	polyarginine	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
19575800-8	2009	Poly-L-arginine enhanced the stimulus-induced IL-6 and IL-8 production, however, blocking arginine uptake and the enhanced IL-6 and IL-8 production appeared unrelated.	Arginine	7-15	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
19575800-9	2009	The exaggerated IL-6 and IL-8 production due to arginine deficiency and to poly-L-arginine depend on a post-transcriptional and a transcriptional process, respectively.	polyarginine	75-90	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
18712273-4	2009	Dietary supplementation with 0.8% arginine increased the numbers of white blood cells and granulocytes, and gene expression of interleukin (IL)-8 in spleen.	Arginine	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	127-145
18712273-5	2009	On Day 14, compared with control piglets, granulocyte numbers were greater but lymphocyte numbers were lower in piglets supplemented with 0.2 and 0.4% arginine, whereas splenic expression of IL-8 and tumor necrosis factor-alpha genes was increased in piglets supplemented with 0.8% arginine.	Arginine	151-159	C-X-C motif chemokine ligand 8	Homo sapiens	191-227
18712273-5	2009	On Day 14, compared with control piglets, granulocyte numbers were greater but lymphocyte numbers were lower in piglets supplemented with 0.2 and 0.4% arginine, whereas splenic expression of IL-8 and tumor necrosis factor-alpha genes was increased in piglets supplemented with 0.8% arginine.	Arginine	282-290	C-X-C motif chemokine ligand 8	Homo sapiens	191-227
19254160-4	2009	Interestingly, both hypoxia and DMOG attenuated IL-8 expression, and a similar effect has been obtained by adenoviral overexpression of the stable form of HIF-1alpha.	dimethyloxallyl glycine	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
19059883-5	2009	In primary human airway epithelial cells, inhibition of NQO1 by dicumarol blocks ozone-induced F(2)-isoprostane production and IL-8 gene expression.	Dicumarol	64-73	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
19059883-5	2009	In primary human airway epithelial cells, inhibition of NQO1 by dicumarol blocks ozone-induced F(2)-isoprostane production and IL-8 gene expression.	Ozone	81-86	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
19415233-7	2009	RESULTS: Treatment of LPS-stimulated human islets with the synthetic LXR agonist GW3965 (1 micromol/l) for 24 h reduced mRNA and protein levels of selected pro-inflammatory cytokines (IL-8, monocyte chemotactic protein-1 and tissue factor).	GW 3965	81-87	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
19318678-7	2009	The major bile acid, chenodeoxycholic acid, stimulated alveolar epithelial cells to increase IL-8 production at both the messenger RNA and protein level through p38 and c-Jun N-terminal kinase (JNK) activation.	Bile Acids and Salts	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
19318678-7	2009	The major bile acid, chenodeoxycholic acid, stimulated alveolar epithelial cells to increase IL-8 production at both the messenger RNA and protein level through p38 and c-Jun N-terminal kinase (JNK) activation.	Chenodeoxycholic Acid	21-42	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
19318678-8	2009	The selective p38 and JNK inhibitors, as well as dexamethasone, successfully inhibited IL-8 production.	Dexamethasone	49-62	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
19132727-2	2009	Titanium particles have previously been shown to induce IL-8 and MCP-1 secretion in osteoblasts.	Titanium	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
19542452-6	2009	Transcriptional blockade studies using actinomycin D revealed a similar degradation rate of IL-8/CXCL8 mRNA in the presence or absence of NE, suggesting an involvement at the transcription level.	Dactinomycin	39-52	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
19558223-7	2009	Finally, the release of a proinflammatory cytokine (i.e. IL-8) by the exposed cells similarly increased with cell iron concentration.	Iron	114-118	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
19916466-1	2009	This paper discusses the preparation of titania nanotubes by anodisation of Ti in a glycerol-based electrolyte containing 0.5% wt of sodium fluoride (NaF).	Sodium Fluoride	133-148	C-X-C motif chemokine ligand 8	Homo sapiens	150-153
19132727-6	2009	We demonstrate that cobalt ions rapidly induce the protein secretion of IL-8 and MCP-1 in primary human osteoblasts.	Cobalt	20-26	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
19132727-10	2009	In aggregate these data demonstrate that cobalt ions can activate transcription of the chemokine genes IL-8 and MCP-1 in primary human osteoblasts.	Cobalt	41-47	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
19522763-4	2009	In addition, poly I:C treatment inhibited cell growth and triggered up-regulation of IL-12p40, IL-8 and Il-1alpha in Detroit 562 cell line.	Poly I-C	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
19184985-8	2009	These data suggest that hypoxia induces biosynthesis of PGF(2alpha), which then activates HGF and IL-8 expression.	Prostaglandins F	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
19184985-9	2009	The results provide a reasonable explanation of how PGF(2alpha), HGF and IL-8 exert their effects on cancer cell metastasis.	Prostaglandins F	52-55	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
19434061-7	2009	Endogenous and TNF-alpha-induced expressions of IL-6, IL-8, p38, p65 and C/EBP-beta were also downregulated by genistein, showing its anti-inflammatory properties.	Genistein	111-120	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
19513849-4	2009	Suppression of IL-8 production was blocked by naloxone and naltrindole.	Naloxone	46-54	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
19513849-4	2009	Suppression of IL-8 production was blocked by naloxone and naltrindole.	naltrindole	59-70	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
19407340-4	2009	Herein, we show that lithium induces a rapid and pronounced up-regulation of the matrix metalloproteinase (MMP)-1, an inflammation and senescent cell marker, at the mRNA and protein levels, whereas the induction of two other senescent cell markers is either weak (interleukin-8) or delayed (plasminogen activator inhibitor-1).	Lithium	21-28	C-X-C motif chemokine ligand 8	Homo sapiens	264-277
19386603-2	2009	Production of the CXC chemokine interleukin (IL)-8/CXCL8 forms a common epithelial response to many diverse stimuli, including bacterial and viral triggers, environmental oxidants, and other biological mediators, suggesting the potential involvement of a common signaling pathway that may involve DUOX1-dependent H2O2 production.	Hydrogen Peroxide	313-317	C-X-C motif chemokine ligand 8	Homo sapiens	51-56
19386603-3	2009	Following previous reports showing that DUOX1 is activated by extracellular ATP and purinergic receptor stimulation, this study demonstrates that airway epithelial IL-8 production in response to several bacterial stimuli involves ATP release and DUOX1 activation.	Adenosine Triphosphate	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
19527497-8	2009	The R848-augmented IL-8 release was significantly potentiated by pretreatment with H2O2 (p &lt; 0.01), and N-acetyl-L-cysteine reversed this potentiation.	Hydrogen Peroxide	83-87	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
19386603-3	2009	Following previous reports showing that DUOX1 is activated by extracellular ATP and purinergic receptor stimulation, this study demonstrates that airway epithelial IL-8 production in response to several bacterial stimuli involves ATP release and DUOX1 activation.	Adenosine Triphosphate	230-233	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
19386603-6	2009	Both ADAM17 activation and IL-8 release were suppressed by inhibitors of EGFR/ERK1/2 signaling, which can regulate ADAM17 activity by serine/threonine phosphorylation.	Serine	134-140	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
19386603-6	2009	Both ADAM17 activation and IL-8 release were suppressed by inhibitors of EGFR/ERK1/2 signaling, which can regulate ADAM17 activity by serine/threonine phosphorylation.	Threonine	141-150	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
19386603-7	2009	Collectively, our results indicate that ATP-mediated DUOX1 activation represents a common response mechanism to several environmental stimuli, involving H2O2-dependent EGFR/ERK activation, ADAM17 activation, and EGFR ligand shedding, leading to amplified epithelial EGFR activation and IL-8 production.	Adenosine Triphosphate	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	286-290
19386603-7	2009	Collectively, our results indicate that ATP-mediated DUOX1 activation represents a common response mechanism to several environmental stimuli, involving H2O2-dependent EGFR/ERK activation, ADAM17 activation, and EGFR ligand shedding, leading to amplified epithelial EGFR activation and IL-8 production.	Hydrogen Peroxide	153-157	C-X-C motif chemokine ligand 8	Homo sapiens	286-290
19527497-10	2009	The H2O2-potentiated IL-8 release was suppressed by MG-132, a proteosome inhibitor, and by dexamethasone.	Hydrogen Peroxide	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
19527497-10	2009	The H2O2-potentiated IL-8 release was suppressed by MG-132, a proteosome inhibitor, and by dexamethasone.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	52-58	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
19527497-10	2009	The H2O2-potentiated IL-8 release was suppressed by MG-132, a proteosome inhibitor, and by dexamethasone.	Dexamethasone	91-104	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
19345231-6	2009	The generation of cytokines of significance for adhesive and proliferative events in host defense, IL-8 and G-CSF, was also potently impaired by EtP.	ethyl pyruvate	145-148	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
19345231-7	2009	SIGNIFICANCE: Exposure of lung epithelial cells to 2.5-10 mM EtP inhibited the generation of inflammatory-regulating cytokines IL-8 and G-CSF, reduced ICAM-1 and VCAM-1 expression and impeded the adhesiveness of neutrophils to lung epithelial cells.	ethyl pyruvate	61-64	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
19201759-11	2009	Luminal ILT layers displayed potent neutrophil chemotactic activity in vitro, which was inhibited by RANTES- and IL-8-blocking antibodies as well as by reparixin, an antagonist of the IL-8 receptors CXCR1 and CXCR2.	reparixin	152-161	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
19349617-0	2009	The 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Janus kinase 2-signal transducer and activator of transcription-5B-dependent expression of interleukin-8.	15-hydroxy-5,8,11,13-eicosatetraenoic acid	4-38	C-X-C motif chemokine ligand 8	Homo sapiens	160-173
19349617-7	2009	In addition, neutralizing anti-IL-8 antibodies reduced 15(S)-HETE-induced HRMVEC migration and tube formation and Matrigel plug angiogenesis.	Hydroxyeicosatetraenoic Acids	61-65	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
19483309-6	2009	PMA plus A23187 significantly increased IL-1beta, IL-6, IL-8, and TNF-alpha production compared with media control (p&lt;0.05).	Calcimycin	9-15	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
19503797-8	2009	AZT pretreatment prevented the up-regulation of some genes, such as MUC5AC and MMP9, triggered by the inflammatory stimulus, but the up-regulation of other inflammatory genes, e.g., cytokines and chemokines, such as interleukin-8, was not affected.	Azithromycin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	216-229
19503797-10	2009	Notably, secreted IL-8 protein levels did not reflect mRNA levels, and were, in fact, higher after AZT pretreatment in cultures exposed to the inflammatory stimulus, suggesting that AZT can affect inflammatory pathways other than by altering gene expression.	Azithromycin	99-102	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
19503797-10	2009	Notably, secreted IL-8 protein levels did not reflect mRNA levels, and were, in fact, higher after AZT pretreatment in cultures exposed to the inflammatory stimulus, suggesting that AZT can affect inflammatory pathways other than by altering gene expression.	Azithromycin	182-185	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
19477431-3	2009	Here, we demonstrate that both IL-8 and angiogenin contribute to the complementary pathways of angiogenesis and BMDC mobilization to increase tumor growth.	bmdc	112-116	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
19234105-9	2009	In addition, UFCAP exposure resulted in a significant increase in blood levels of the fibrin degradation product D-dimer as well as a modest elevation in the inflammatory chemokine IL-8 recovered in the lavage fluid.	ufcap	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
19357230-0	2009	Lipoxin A4 inhibits IL-1beta-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells.	lipoxin A4	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
19357230-7	2009	As shown by quantitative RT-PCR, LXA(4) (10 nM) significantly inhibited (P &lt; 0.05) the IL-1beta-induced stimulation of IL-8 and ICAM-1 expression in these cells.	N-(1H-benzimidazol-2-ylmethyl)-2-methoxyacetamide	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
19357230-8	2009	Furthermore, LXA(4) (10 nM) decreased the expression of IL-1beta-induced IL-8 protein levels (P &lt; 0.05).	lipoxin A4	13-19	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
19299007-10	2009	The materials may also suppress excessive inflammation by adsorption of the cytokine IL-8 into the porous, internal carbon structure.	Carbon	116-122	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
19517319-4	2009	In a phase IIa trial in patients with prostatitis, elocalcitol significantly reduced levels of IL-8 in semen, suggesting improved quality and forward motility of sperm.	BXL628	51-62	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
19514995-6	2009	MW (1 mg/ml) inhibited PMA plus A23187-stimulated gene expression and production of TNF-alpha, IL-6, and IL-8.	Calcimycin	32-38	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
19401270-4	2009	In these studies, the effect of 17beta-estradiol (E(2)) on the expression levels of IL-6, IL-8 and their receptors was investigated.	Estradiol	32-48	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
19401270-8	2009	Tamoxifen (Txf), an ER antagonist, completely abolished E(2)-stimulated cell growth and the expression of IL-6 and IL-8.	Tamoxifen	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
19401270-8	2009	Tamoxifen (Txf), an ER antagonist, completely abolished E(2)-stimulated cell growth and the expression of IL-6 and IL-8.	Tamoxifen	11-14	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
19401270-8	2009	Tamoxifen (Txf), an ER antagonist, completely abolished E(2)-stimulated cell growth and the expression of IL-6 and IL-8.	Estradiol	56-60	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
19401270-9	2009	IL-6/IL-8-induced cell proliferation was completely blocked by their specific neutralizing antibodies, which partially inhibited E(2)-induced cell growth.	Estradiol	129-133	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
19398228-7	2009	Silybin (25-50 microM), inhibited the IL-1-induced synthesis of MCP-1 (P &lt; 0.01) and IL-8 (P &lt; 0.01) showing a potent anti-inflammatory activity.	Silybin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
19454720-6	2009	Induction of CCL2, CCL7, CXCL3, and CXCL8 by anti-IgE was significantly inhibited by dexamethasone but was enhanced by FK506.	Tacrolimus	119-124	C-X-C motif chemokine ligand 8	Homo sapiens	36-41
19454705-5	2009	UDP-glucose stimulated IL-8 production via P2RY14 in human endometrial epithelial cells but not stromal cells.	Uridine Diphosphate Glucose	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
19307749-7	2009	The suppressive effect of dexamethasone on TNF-alpha-induced IL-8 transcription was not affected by GRbeta overexpression, rather GRbeta had its own weak suppressive activity on TNF-alpha-induced IL-8 expression.	Dexamethasone	26-39	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
19454705-6	2009	Furthermore, UDP-glucose enhanced neutrophil chemotaxis in the presence of a human endometrial epithelial cell line in an IL-8-dependent manner.	Uridine Diphosphate Glucose	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
19439372-3	2009	Thus, aluminum salts activate dendritic cells, monocytes and macrophages with enhanced expression of adhesion molecules CD54 and CD58 and co-stimulatory molecules CD40 and CD86, which are crucial in T cell activation; induce chemokines CCL2, CCL3, CCL4 and CXCL8, which mediate recruitment of inflammatory cells at the site of vaccination; and stimulate cytokines crucial in the innate immune response.	aluminum salts	6-20	C-X-C motif chemokine ligand 8	Homo sapiens	257-262
19454720-6	2009	Induction of CCL2, CCL7, CXCL3, and CXCL8 by anti-IgE was significantly inhibited by dexamethasone but was enhanced by FK506.	Dexamethasone	85-98	C-X-C motif chemokine ligand 8	Homo sapiens	36-41
19485829-5	2009	RESULTS: Laser irradiation of LPS-coated titanium disks significantly reduced LPS-induced nitric oxide production and cell activation by the macrophages and strongly attenuated intercellular adhesion molecule-1 and vascular cell adhesion molecule expression, as well as interleukin-8 production by the endothelial cells.	Titanium	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	270-283
19185596-9	2009	An NF-kappaB inhibitor, TPCK (N-Tosyl-L-Phenylalanine Chloromethyl Ketone) could suppress IL-8 production and secretion in response to S protein in PBMC and THP-1 cells and in HCoV-229E virus-infected PBMC.	Tosylphenylalanyl Chloromethyl Ketone	30-73	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
19470239-0	2009	Inhibitory effects of flavonoids on TNF-alpha-induced IL-8 gene expression in HEK 293 cells.	Flavonoids	22-32	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
19135038-6	2009	Our results showed that preincubation with 20 microM beta-carotene significantly enhanced the release of two pro-inflammatory mediators, interleukin-8 and tumor necrosis factor-alpha, in PMA-stimulated HL-60 cells and slightly increased the DNA-damaging ability of these cells.	beta Carotene	53-66	C-X-C motif chemokine ligand 8	Homo sapiens	137-182
19470239-2	2009	In this study, we demonstrated that several flavonoids, including kaempferol, quercetin, fisetin, and chrysin block TNF-alpha induced IL-8 promoter activation and gene expression in HEK 293 cells.	Flavonoids	44-54	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
19470239-2	2009	In this study, we demonstrated that several flavonoids, including kaempferol, quercetin, fisetin, and chrysin block TNF-alpha induced IL-8 promoter activation and gene expression in HEK 293 cells.	kaempferol	66-76	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
19470239-2	2009	In this study, we demonstrated that several flavonoids, including kaempferol, quercetin, fisetin, and chrysin block TNF-alpha induced IL-8 promoter activation and gene expression in HEK 293 cells.	Quercetin	78-87	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
19470239-2	2009	In this study, we demonstrated that several flavonoids, including kaempferol, quercetin, fisetin, and chrysin block TNF-alpha induced IL-8 promoter activation and gene expression in HEK 293 cells.	fisetin	89-96	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
19452583-7	2009	HP-NAP could slightly up-regulate IL-8 production in gastric epithelial cell lines but had no effect on GRO(alpha) production.	hp-nap	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
19394230-0	2009	6-amino-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl derivatives as a new class of potent inhibitors of Interleukin-8-induced neutrophil chemotaxis.	6-amino-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine	0-64	C-X-C motif chemokine ligand 8	Homo sapiens	127-140
19394230-0	2009	6-amino-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl derivatives as a new class of potent inhibitors of Interleukin-8-induced neutrophil chemotaxis.	derivatives	76-87	C-X-C motif chemokine ligand 8	Homo sapiens	127-140
19454816-7	2009	RESULTS: A significant effect of the etiology on the levels of IL-8 in the alcohol group as compared to the gallstone group (P=0.003) was found.	Alcohols	75-82	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
19173296-0	2009	Regulation of deoxycholate induction of CXCL8 by the adenomatous polyposis coli gene in colorectal cancer.	Deoxycholic Acid	14-26	C-X-C motif chemokine ligand 8	Homo sapiens	40-45
19173296-3	2009	DCA increased steady state mRNA and protein levels of CXCL8 in cells which do not express wild-type APC.	Deoxycholic Acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	54-59
19173296-4	2009	Steady-state CXCL8 mRNA and protein were suppressed when cells with conditional expression of wild-type APC were exposed to DCA.	Deoxycholic Acid	124-127	C-X-C motif chemokine ligand 8	Homo sapiens	13-18
19349368-5	2009	Incubating human microvascular endothelial cells with the sphingosine-1-phosphate type 1 receptor (S1P(1)) inhibitor VPC23019 or performing small interfering RNA knockdown of S1P(1) blocked arsenic-stimulated HMVEC angiogenic gene expression and tube formation, but did not affect induction of either HMOX1 or IL8.	Arsenic	190-197	C-X-C motif chemokine ligand 8	Homo sapiens	310-313
19173296-10	2009	Mutation of activator protein-1 (AP-1) or nuclear factor kappa B (NF-kappaB) sites suppressed the activation of the CXCL8 promoter-reporter by DCA.	Deoxycholic Acid	143-146	C-X-C motif chemokine ligand 8	Homo sapiens	116-121
19173296-11	2009	Chromatin immunoprecipitation revealed that AP-1 and NF-kappaB binding to the 5"-promoter of CXCL8 was induced by DCA.	Deoxycholic Acid	114-117	C-X-C motif chemokine ligand 8	Homo sapiens	93-98
19173296-13	2009	Phenotypic assays determined that DCA-mediated invasion was blocked by antibody-directed against CXCL8 or wild-type APC.	Deoxycholic Acid	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	97-102
19173296-15	2009	These data suggest that DCA-mediated CXCL8 occurs in initiated colonic epithelium and neutralizing CXCL8 could reduce the invasive potential of tumors.	Deoxycholic Acid	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	37-42
19173296-15	2009	These data suggest that DCA-mediated CXCL8 occurs in initiated colonic epithelium and neutralizing CXCL8 could reduce the invasive potential of tumors.	Deoxycholic Acid	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	99-104
19452017-9	2009	RESULTS: The expressions of MIP1-alpha, MIP1-beta, IL-6, IL-8, RANTES, IFN-beta, and TLR3 were up-regulated in HCECs exposed to poly(I:C).	poly	128-132	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
19452017-10	2009	The poly(I:C)-induced expressions of IL-6 and IL-8 were down-regulated by both DEX and CsA, while the expressions of IFN-beta and TLR3 were suppressed by DEX alone.	Poly I-C	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
19452017-10	2009	The poly(I:C)-induced expressions of IL-6 and IL-8 were down-regulated by both DEX and CsA, while the expressions of IFN-beta and TLR3 were suppressed by DEX alone.	Dexamethasone	79-82	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
19461497-8	2009	Furthermore, eCO levels significantly correlated with BAL neutrophilia and IL-8 levels in the cohort as a whole (r=0.50; P=0.0005 for total cells, r=0.43; P=0.003 for %cells and r=0.30; P=0.045 for IL-8).	ECO	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
19461497-8	2009	Furthermore, eCO levels significantly correlated with BAL neutrophilia and IL-8 levels in the cohort as a whole (r=0.50; P=0.0005 for total cells, r=0.43; P=0.003 for %cells and r=0.30; P=0.045 for IL-8).	ECO	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	198-202
19258275-3	2009	In NHEK, the production of IL-8 stimulated by an agonist peptide of PAR2, SLIGKIV-NH(2), at 100 microM was significantly reduced by TET, DOX, or MIN at 5 and 10 microM, concentrations that are noncytotoxic.	tet	132-135	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
19286926-0	2009	alpha,beta-Unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through mitogen-activated protein kinases.	alpha,beta-unsaturated aldehydes	0-32	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
19286926-3	2009	By examining a panel of 19 cytokines and chemokines, we found that IL-8 release was elevated by CSE as well as by acrolein, whereas other inflammatory mediators were mostly unaffected.	Acrolein	114-122	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
19286926-4	2009	CSE-evoked IL-8 release was mimicked by acrolein and crotonaldehyde at concentrations (3-60 microM each) found in CSE and fully prevented by 1 mM alpha,beta-unsaturated aldehydes scavengers N-acetylcysteine (NAC) or sodium 2-mercaptoethanesulfonate.	Acrolein	40-48	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
19286926-4	2009	CSE-evoked IL-8 release was mimicked by acrolein and crotonaldehyde at concentrations (3-60 microM each) found in CSE and fully prevented by 1 mM alpha,beta-unsaturated aldehydes scavengers N-acetylcysteine (NAC) or sodium 2-mercaptoethanesulfonate.	2-butenal	53-67	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
19286926-4	2009	CSE-evoked IL-8 release was mimicked by acrolein and crotonaldehyde at concentrations (3-60 microM each) found in CSE and fully prevented by 1 mM alpha,beta-unsaturated aldehydes scavengers N-acetylcysteine (NAC) or sodium 2-mercaptoethanesulfonate.	alpha,beta-unsaturated aldehydes	146-178	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
19286926-4	2009	CSE-evoked IL-8 release was mimicked by acrolein and crotonaldehyde at concentrations (3-60 microM each) found in CSE and fully prevented by 1 mM alpha,beta-unsaturated aldehydes scavengers N-acetylcysteine (NAC) or sodium 2-mercaptoethanesulfonate.	Acetylcysteine	190-206	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
19286926-4	2009	CSE-evoked IL-8 release was mimicked by acrolein and crotonaldehyde at concentrations (3-60 microM each) found in CSE and fully prevented by 1 mM alpha,beta-unsaturated aldehydes scavengers N-acetylcysteine (NAC) or sodium 2-mercaptoethanesulfonate.	Acetylcysteine	208-211	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
19286926-4	2009	CSE-evoked IL-8 release was mimicked by acrolein and crotonaldehyde at concentrations (3-60 microM each) found in CSE and fully prevented by 1 mM alpha,beta-unsaturated aldehydes scavengers N-acetylcysteine (NAC) or sodium 2-mercaptoethanesulfonate.	Mesna	216-248	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
19286926-6	2009	In addition, CSE or crotonaldehyde upregulated the release of IL-8 from alveolar macrophages from both COPD patients and healthy nonsmokers, indicating that this is a response common to cells involved in lung inflammation.	2-butenal	20-34	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
19286926-10	2009	In summary, our data show that alpha,beta-unsaturated aldehydes-evoked phosphorylation of p38 and ERK1/2 underlies IL-8 release elicited by CSE, thus shedding light on the mechanisms through which cigarette smoke can initiate inflammation in the lung.	alpha,beta-unsaturated aldehydes	31-63	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
19286927-0	2009	Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells.	Ceramides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
19286927-5	2009	Inhibition of PP2A using okadaic acid or gene knockdown using siRNA resulted in an augmentation of TNFalpha-induced IL-8 production.	Okadaic Acid	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
19286927-8	2009	Inhibition of the immediate sphingomyelinase-dependent pathway as well as the de novo synthesis pathway of ceramide production reduced serine/threonine phosphatase activity and augmented IL-8 production.	Ceramides	107-115	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
19286927-9	2009	These data suggest that ceramide plays a role in activating PP2A to terminate ongoing IL-8 production.	Ceramides	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
19286927-10	2009	In summary, our data suggest that in respiratory epithelium, TNFalpha induces ceramide accumulation, resulting in subsequent activation of PP2A, which targets those kinases responsible for transcriptional activation of IL-8.	Ceramides	78-86	C-X-C motif chemokine ligand 8	Homo sapiens	219-223
19258275-2	2009	In this study, we examined the effects of tetracycline (TET) and two of its derivatives, doxycycline (DOX) and minocycline (MIN), on the production of interleukin-8 (IL-8) elicited by the activation of protease-activated receptor 2 (PAR2) in normal human epidermal keratinocytes (NHEK).	Tetracycline	42-54	C-X-C motif chemokine ligand 8	Homo sapiens	151-164
19258275-2	2009	In this study, we examined the effects of tetracycline (TET) and two of its derivatives, doxycycline (DOX) and minocycline (MIN), on the production of interleukin-8 (IL-8) elicited by the activation of protease-activated receptor 2 (PAR2) in normal human epidermal keratinocytes (NHEK).	Tetracycline	42-54	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
19258275-2	2009	In this study, we examined the effects of tetracycline (TET) and two of its derivatives, doxycycline (DOX) and minocycline (MIN), on the production of interleukin-8 (IL-8) elicited by the activation of protease-activated receptor 2 (PAR2) in normal human epidermal keratinocytes (NHEK).	tet	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	151-164
19258275-2	2009	In this study, we examined the effects of tetracycline (TET) and two of its derivatives, doxycycline (DOX) and minocycline (MIN), on the production of interleukin-8 (IL-8) elicited by the activation of protease-activated receptor 2 (PAR2) in normal human epidermal keratinocytes (NHEK).	tet	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
19258275-2	2009	In this study, we examined the effects of tetracycline (TET) and two of its derivatives, doxycycline (DOX) and minocycline (MIN), on the production of interleukin-8 (IL-8) elicited by the activation of protease-activated receptor 2 (PAR2) in normal human epidermal keratinocytes (NHEK).	Doxycycline	89-100	C-X-C motif chemokine ligand 8	Homo sapiens	151-164
19258275-3	2009	In NHEK, the production of IL-8 stimulated by an agonist peptide of PAR2, SLIGKIV-NH(2), at 100 microM was significantly reduced by TET, DOX, or MIN at 5 and 10 microM, concentrations that are noncytotoxic.	Doxycycline	137-140	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
19258275-2	2009	In this study, we examined the effects of tetracycline (TET) and two of its derivatives, doxycycline (DOX) and minocycline (MIN), on the production of interleukin-8 (IL-8) elicited by the activation of protease-activated receptor 2 (PAR2) in normal human epidermal keratinocytes (NHEK).	Doxycycline	89-100	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
19258275-2	2009	In this study, we examined the effects of tetracycline (TET) and two of its derivatives, doxycycline (DOX) and minocycline (MIN), on the production of interleukin-8 (IL-8) elicited by the activation of protease-activated receptor 2 (PAR2) in normal human epidermal keratinocytes (NHEK).	Doxycycline	102-105	C-X-C motif chemokine ligand 8	Homo sapiens	151-164
19258275-2	2009	In this study, we examined the effects of tetracycline (TET) and two of its derivatives, doxycycline (DOX) and minocycline (MIN), on the production of interleukin-8 (IL-8) elicited by the activation of protease-activated receptor 2 (PAR2) in normal human epidermal keratinocytes (NHEK).	Doxycycline	102-105	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
19258275-2	2009	In this study, we examined the effects of tetracycline (TET) and two of its derivatives, doxycycline (DOX) and minocycline (MIN), on the production of interleukin-8 (IL-8) elicited by the activation of protease-activated receptor 2 (PAR2) in normal human epidermal keratinocytes (NHEK).	Minocycline	111-122	C-X-C motif chemokine ligand 8	Homo sapiens	151-164
19258275-2	2009	In this study, we examined the effects of tetracycline (TET) and two of its derivatives, doxycycline (DOX) and minocycline (MIN), on the production of interleukin-8 (IL-8) elicited by the activation of protease-activated receptor 2 (PAR2) in normal human epidermal keratinocytes (NHEK).	Minocycline	111-122	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
19258275-6	2009	These results suggest that tetracyclines attenuate the PAR2-IL-8 axis in keratinocytes and thereby effectively modulate proinflammatory responses in the skin.	Tetracyclines	27-40	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
19362486-2	2009	These compounds were designed as development of previous pyrazole-urea derivatives that resulted potent IL8-induced neutrophil chemotaxis inhibitors in vitro.	pyrazole	57-65	C-X-C motif chemokine ligand 8	Homo sapiens	104-107
19711862-3	2009	Microgravity effects simulated with the use of RPM raised the IL-8 production 1.5 - 6 times and 1.6-2.1 times on the average after 10 days and 20 days of containment, respectively.	Sirolimus	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
19229069-0	2009	Human IL-8 regulates smooth muscle cell VCAM-1 expression in response to endothelial cells exposed to atheroprone flow.	atheroprone	102-113	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
19229069-2	2009	Recently, we showed that atheroprone hemodynamics induced IL-8 secretion from endothelial cells (ECs) concurrent with increased EC/smooth muscle cell (SMC) VCAM-1 expression in a human hemodynamic coculture model.	atheroprone	25-36	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
19362486-2	2009	These compounds were designed as development of previous pyrazole-urea derivatives that resulted potent IL8-induced neutrophil chemotaxis inhibitors in vitro.	Urea	66-70	C-X-C motif chemokine ligand 8	Homo sapiens	104-107
19303321-3	2009	Indeed, the migration of human neutrophils towards IL-8 was significantly inhibited by the P2Y receptor antagonists, suramin and reactive blue 2 (RB-2) and potentiated by a P2Y(2) ligand, ATP, but insensitive to specific antagonists of P2Y(1), P2Y(6) and P2Y(11) receptors.	Suramin	117-124	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
19303321-3	2009	Indeed, the migration of human neutrophils towards IL-8 was significantly inhibited by the P2Y receptor antagonists, suramin and reactive blue 2 (RB-2) and potentiated by a P2Y(2) ligand, ATP, but insensitive to specific antagonists of P2Y(1), P2Y(6) and P2Y(11) receptors.	Cibacron Blue F 3GA	129-144	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
19303321-3	2009	Indeed, the migration of human neutrophils towards IL-8 was significantly inhibited by the P2Y receptor antagonists, suramin and reactive blue 2 (RB-2) and potentiated by a P2Y(2) ligand, ATP, but insensitive to specific antagonists of P2Y(1), P2Y(6) and P2Y(11) receptors.	Adenosine Triphosphate	188-191	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
19085995-6	2009	Data demonstrated that DSS activates IkappaBalpha, NFkappaB, and IL-8 through an ROS-Hsp27-IKKbeta-mediated pathway, and not through an innate immune cascade.	Reactive Oxygen Species	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
19303321-5	2009	Taken together, these data suggest that extracellular ATP is necessary for IL-8 to exert its chemotactic effect on neutrophils.	Adenosine Triphosphate	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
19285497-0	2009	Sphingosine-1-phosphate increases human alveolar epithelial IL-8 secretion, proliferation and neutrophil chemotaxis.	sphingosine 1-phosphate	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
19085995-3	2009	METHODS: DSS-induced increases in phospho-IkappaBalpha, nuclear NFkappaB (p65), and IL-8 secretion in human colonic epithelial cells in tissue culture are attributable to a reactive oxygen species (ROS)-induced pathway of inflammation, and do not require TLR4, MyD88, or Bcl10, which are associated with the innate immune pathway of NFkappaB-IL-8 activation.	dss	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
19241441-5	2009	Evodiamine and rutaecarpine decreased the LIGHT-induced production of ROS, IL-8, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, and IL-6, as well as the expression of chemokine receptor (CCR) 1, CCR2 and ICAM-1 and the phosphorylation of the ERK 1/2 and p38 MAPK.	evodiamine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
19085995-3	2009	METHODS: DSS-induced increases in phospho-IkappaBalpha, nuclear NFkappaB (p65), and IL-8 secretion in human colonic epithelial cells in tissue culture are attributable to a reactive oxygen species (ROS)-induced pathway of inflammation, and do not require TLR4, MyD88, or Bcl10, which are associated with the innate immune pathway of NFkappaB-IL-8 activation.	dss	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	342-346
19085995-3	2009	METHODS: DSS-induced increases in phospho-IkappaBalpha, nuclear NFkappaB (p65), and IL-8 secretion in human colonic epithelial cells in tissue culture are attributable to a reactive oxygen species (ROS)-induced pathway of inflammation, and do not require TLR4, MyD88, or Bcl10, which are associated with the innate immune pathway of NFkappaB-IL-8 activation.	Reactive Oxygen Species	173-196	C-X-C motif chemokine ligand 8	Homo sapiens	342-346
19085995-6	2009	Data demonstrated that DSS activates IkappaBalpha, NFkappaB, and IL-8 through an ROS-Hsp27-IKKbeta-mediated pathway, and not through an innate immune cascade.	dss	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
19360326-6	2009	Compared to untreated cells, expression of intracellular HO-1-protein and release of IL-8 into cell culture supernatants and corresponding mRNA expression were attenuated in THP-1 cells exposed to sevoflurane and isoflurane, respectively.	Sevoflurane	197-208	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
19360326-6	2009	Compared to untreated cells, expression of intracellular HO-1-protein and release of IL-8 into cell culture supernatants and corresponding mRNA expression were attenuated in THP-1 cells exposed to sevoflurane and isoflurane, respectively.	Isoflurane	213-223	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
19241441-5	2009	Evodiamine and rutaecarpine decreased the LIGHT-induced production of ROS, IL-8, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, and IL-6, as well as the expression of chemokine receptor (CCR) 1, CCR2 and ICAM-1 and the phosphorylation of the ERK 1/2 and p38 MAPK.	rutecarpine	15-27	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
19085995-0	2009	ROS, Hsp27, and IKKbeta mediate dextran sodium sulfate (DSS) activation of IkappaBa, NFkappaB, and IL-8.	Reactive Oxygen Species	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
19085995-0	2009	ROS, Hsp27, and IKKbeta mediate dextran sodium sulfate (DSS) activation of IkappaBa, NFkappaB, and IL-8.	dextran sodium sulfate	32-54	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
19085995-0	2009	ROS, Hsp27, and IKKbeta mediate dextran sodium sulfate (DSS) activation of IkappaBa, NFkappaB, and IL-8.	dss	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
19434815-0	2009	Treatment with levamisole and colchicine can result in a significant reduction of IL-6, IL-8 or TNF-alpha level in patients with mucocutaneous type of Behcet"s disease.	Levamisole	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
19220658-11	2009	In addition, we found muscovite inhibited the expression of TNF-alpha, IL-1beta secreted by THP-1 and IL-8 secreted by HT-29 cells in a dose-dependent manner.	muscovite	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
19434815-6	2009	CONCLUSIONS: Treatment with levamisole and colchicine can result in a significant reduction of serum IL-6, IL-8 or TNF-alpha level in MCBD patients.	Levamisole	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
19434815-6	2009	CONCLUSIONS: Treatment with levamisole and colchicine can result in a significant reduction of serum IL-6, IL-8 or TNF-alpha level in MCBD patients.	Colchicine	43-53	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
19434815-0	2009	Treatment with levamisole and colchicine can result in a significant reduction of IL-6, IL-8 or TNF-alpha level in patients with mucocutaneous type of Behcet"s disease.	Colchicine	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
19416633-6	2009	Resveratrol significantly inhibited the PMA plus A23187-induction of inflammatory cytokines such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
19416633-6	2009	Resveratrol significantly inhibited the PMA plus A23187-induction of inflammatory cytokines such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8.	Tetradecanoylphorbol Acetate	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
21475837-5	2009	PGE2 alone has no effect on IL-8 production, but in cells pretreated with IL-1beta it markedly enhances IL-8 production.	Dinoprostone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
21475837-6	2009	Moreover, a stimulatory effect of PGE2 on IL-8 production in the synoviocyte MH7A cells was observed.	Dinoprostone	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
21475837-7	2009	These results indicate that, in the synovial tissues of patients with rheumatoid arthritis, PGE2 stimulates the release of IL-8 from the fibroblastic cells classified as present, thereby exacerbating inflammation.	Dinoprostone	92-96	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
19416633-6	2009	Resveratrol significantly inhibited the PMA plus A23187-induction of inflammatory cytokines such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8.	Calcimycin	49-55	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
19175556-6	2009	Despite similar pulmonary function and histologic markers of injury in both groups and higher IL-1beta in the donor of ACDD, IL-8 during reperfusion was significantly lower in ACDD (119 +/- 33% of basal) than in HBD (306 +/- 238%, P &lt; 0.05) recipients.	acdd	176-180	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
19416633-10	2009	Resveratrol suppressed the expression of TNF-alpha, IL-6, IL-8 and COX-2 through a decrease in the intracellular levels of Ca2+ and ERK 1/2, as well as activation of NF-kappaB.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
19158122-8	2009	The addition of low-dose theophylline increased HDAC activity and further reduced IL8 and TNFalpha concentrations.	Theophylline	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
19103478-9	2009	We suggest that HM can modulate the inflammatory response by inducing IL-8 and IL-6 production via TLR4-dependent activation of the NF-kappaB signaling pathway.	His-Met	16-18	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
19324137-7	2009	The IL-6 and IL-8 levels were lower in the GAE group (ratio 0.83, 95% confidence interval: 0.68 to 1.02; p = 0.070) than in the GA group (ratio 0.90, 95% confidence interval: 0.78 to 1.02; p = 0.090).	gae	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
19563733-5	2009	Furthermore, TNF-alpha-induced MCP-1 and IL-8 mRNA expression levels were also attenuated by pretreatment with EZS.	1-[1-(4-fluorobenzyl)-2-methyl-1H-imidazol-4-yl]-1-ethanone	111-114	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
19355766-1	2009	Here we report on the polarization dependent nonresonant second harmonic generation (SHG) measurement of the interfacial water molecules at the aqueous solution of the following salts: NaF, NaCl, NaBr, KF, KCl, and KBr.	Water	121-126	C-X-C motif chemokine ligand 8	Homo sapiens	185-188
19355766-4	2009	Noticeably, both the cations and the anions contributed to the changes, and the abilities to increase the thickness of the interfacial water layer were in the following order: KBr &gt; NaBr &gt; KCl &gt; NaCl approximately NaF &gt; KF.	Water	135-140	C-X-C motif chemokine ligand 8	Homo sapiens	223-226
19355766-4	2009	Noticeably, both the cations and the anions contributed to the changes, and the abilities to increase the thickness of the interfacial water layer were in the following order: KBr &gt; NaBr &gt; KCl &gt; NaCl approximately NaF &gt; KF.	Potassium Chloride	195-198	C-X-C motif chemokine ligand 8	Homo sapiens	223-226
19355767-1	2009	Sum frequency generation vibrational spectra of the water molecules at the NaF and KF aqueous solution surfaces showed significantly different spectral features and different concentration dependence.	Water	52-57	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
18317936-0	2009	7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependent.	cholest-5-en-3 beta,7 alpha-diol	0-24	C-X-C motif chemokine ligand 8	Homo sapiens	59-72
18317936-0	2009	7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependent.	cholest-5-en-3 beta,7 alpha-diol	0-24	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
18317936-8	2009	These results demonstrate that oxysterol-induced IL-8 secretion is a calcium-dependent phenomenon involving the MEK/ERK1/2 pathway leading to the activation of IL-8 gene via AP-1 (c-fos).	Oxysterols	31-40	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
18317936-0	2009	7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependent.	25-hydroxycholesterol	29-50	C-X-C motif chemokine ligand 8	Homo sapiens	59-72
18317936-8	2009	These results demonstrate that oxysterol-induced IL-8 secretion is a calcium-dependent phenomenon involving the MEK/ERK1/2 pathway leading to the activation of IL-8 gene via AP-1 (c-fos).	Calcium	69-76	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
18317936-0	2009	7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependent.	25-hydroxycholesterol	29-50	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
18317936-8	2009	These results demonstrate that oxysterol-induced IL-8 secretion is a calcium-dependent phenomenon involving the MEK/ERK1/2 pathway leading to the activation of IL-8 gene via AP-1 (c-fos).	Calcium	69-76	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
18317936-0	2009	7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependent.	Calcium	94-101	C-X-C motif chemokine ligand 8	Homo sapiens	59-72
18317936-0	2009	7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependent.	Calcium	94-101	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
18317936-0	2009	7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependent.	Calcium	218-225	C-X-C motif chemokine ligand 8	Homo sapiens	59-72
18317936-2	2009	An oxysterol-induced interleukin-8 (IL-8) secretion in human monocytes/macrophages has been previously noticed, but the mechanisms remained unclear.	Oxysterols	3-12	C-X-C motif chemokine ligand 8	Homo sapiens	21-34
18317936-2	2009	An oxysterol-induced interleukin-8 (IL-8) secretion in human monocytes/macrophages has been previously noticed, but the mechanisms remained unclear.	Oxysterols	3-12	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
18317936-3	2009	In this paper, we investigated the signaling pathways leading to the induction of IL-8 secretion in monocytic THP-1 cells treated with 7beta-hydroxycholesterol, a cytototoxic oxysterol, or with 25-hydroxycholesterol, an oxysterol non-cytotoxic toward this cell line.	cholest-5-en-3 beta,7 alpha-diol	135-159	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
18317936-3	2009	In this paper, we investigated the signaling pathways leading to the induction of IL-8 secretion in monocytic THP-1 cells treated with 7beta-hydroxycholesterol, a cytototoxic oxysterol, or with 25-hydroxycholesterol, an oxysterol non-cytotoxic toward this cell line.	Oxysterols	175-184	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
19076731-7	2009	Clarithromycin reduced the lavage fluid levels of IL-8 at the low-dose histamine observation (P&lt;0.001).	Clarithromycin	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
18317936-3	2009	In this paper, we investigated the signaling pathways leading to the induction of IL-8 secretion in monocytic THP-1 cells treated with 7beta-hydroxycholesterol, a cytototoxic oxysterol, or with 25-hydroxycholesterol, an oxysterol non-cytotoxic toward this cell line.	25-hydroxycholesterol	194-215	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
19076731-7	2009	Clarithromycin reduced the lavage fluid levels of IL-8 at the low-dose histamine observation (P&lt;0.001).	Histamine	71-80	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
18317936-3	2009	In this paper, we investigated the signaling pathways leading to the induction of IL-8 secretion in monocytic THP-1 cells treated with 7beta-hydroxycholesterol, a cytototoxic oxysterol, or with 25-hydroxycholesterol, an oxysterol non-cytotoxic toward this cell line.	Oxysterols	220-229	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
18317936-4	2009	The oxysterol-induced IL-8 secretion appears to be a calcium-dependent phenomenon as shown by the use of calcium channel blockers, which strongly decreased IL-8 secretion and IL-8 messenger RNA (mRNA) levels.	Oxysterols	4-13	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
18317936-4	2009	The oxysterol-induced IL-8 secretion appears to be a calcium-dependent phenomenon as shown by the use of calcium channel blockers, which strongly decreased IL-8 secretion and IL-8 messenger RNA (mRNA) levels.	Oxysterols	4-13	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
18317936-4	2009	The oxysterol-induced IL-8 secretion appears to be a calcium-dependent phenomenon as shown by the use of calcium channel blockers, which strongly decreased IL-8 secretion and IL-8 messenger RNA (mRNA) levels.	Oxysterols	4-13	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
18317936-4	2009	The oxysterol-induced IL-8 secretion appears to be a calcium-dependent phenomenon as shown by the use of calcium channel blockers, which strongly decreased IL-8 secretion and IL-8 messenger RNA (mRNA) levels.	Calcium	53-60	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
18317936-4	2009	The oxysterol-induced IL-8 secretion appears to be a calcium-dependent phenomenon as shown by the use of calcium channel blockers, which strongly decreased IL-8 secretion and IL-8 messenger RNA (mRNA) levels.	Calcium	53-60	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
18317936-4	2009	The oxysterol-induced IL-8 secretion appears to be a calcium-dependent phenomenon as shown by the use of calcium channel blockers, which strongly decreased IL-8 secretion and IL-8 messenger RNA (mRNA) levels.	Calcium	53-60	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
18317936-8	2009	These results demonstrate that oxysterol-induced IL-8 secretion is a calcium-dependent phenomenon involving the MEK/ERK1/2 pathway leading to the activation of IL-8 gene via AP-1 (c-fos).	Oxysterols	31-40	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
19089992-10	2009	Both 10% and 12% strain levels caused an increase in IL-8 production by hMSCs that was dependent on the presence of dexamethasone.	Dexamethasone	116-129	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
19232500-2	2009	Circulating IL-8 is comprised of an endothelial-derived [ala-IL-8](77) isoform and another, more potent [ser-IL-8](72) secreted by most other cells; [ala-IL-8](77) can be converted into [ser-IL-8](72) by proteolytic removal of an N-terminal pentapeptide from [ala-IL-8](77).	Serine	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
19232500-2	2009	Circulating IL-8 is comprised of an endothelial-derived [ala-IL-8](77) isoform and another, more potent [ser-IL-8](72) secreted by most other cells; [ala-IL-8](77) can be converted into [ser-IL-8](72) by proteolytic removal of an N-terminal pentapeptide from [ala-IL-8](77).	Serine	187-190	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
19232500-3	2009	In this study, we show [ala-IL-8](77) is the predominant circulating isoform of IL-8 in premature neonates but not in term neonates/adults, who have [ser-IL-8](72) as the major isoform.	Alanine	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
19159427-6	2009	The adhesin could also induce interleukin-8 secretion from INT-407 cells, which was inhibited in the presence of dantrolene as well as staurosporin (inhibitor of PKC).	Dantrolene	113-123	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
19159427-6	2009	The adhesin could also induce interleukin-8 secretion from INT-407 cells, which was inhibited in the presence of dantrolene as well as staurosporin (inhibitor of PKC).	Staurosporine	135-147	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
19373630-0	2009	Asthma drugs counter-regulate interleukin-8 release stimulated by sodium sulfite in an A549 cell line.	sodium sulfite	66-80	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
19373630-6	2009	To date, there have not been any reports on the effect of asthma drugs on the suppression of IL-8 production induced by sulfite in A549 cells or the involvement of specific signal transduction pathways.	Sulfites	120-127	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
19373630-10	2009	RESULTS: IL-8 production increased after treatment with sodium sulfite at 1000 to 2500 uM (p &lt;or= 0.001).	sodium sulfite	56-70	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
19373630-11	2009	SB203580, PD98059, and wedeloactone decreased IL-8 production stimulated by Na(2)SO(3) (p &lt; 0.01).	SB 203580	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
19373630-11	2009	SB203580, PD98059, and wedeloactone decreased IL-8 production stimulated by Na(2)SO(3) (p &lt; 0.01).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	10-17	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
19232500-3	2009	In this study, we show [ala-IL-8](77) is the predominant circulating isoform of IL-8 in premature neonates but not in term neonates/adults, who have [ser-IL-8](72) as the major isoform.	Alanine	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
19232500-3	2009	In this study, we show [ala-IL-8](77) is the predominant circulating isoform of IL-8 in premature neonates but not in term neonates/adults, who have [ser-IL-8](72) as the major isoform.	Alanine	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
19232500-4	2009	This isoform switch from the less potent [ala-IL-8](77) to [ser-IL-8](72) correlates with a maturational increase in the neutrophil chemotactic potency of plasma IL-8.	Alanine	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
19232500-4	2009	This isoform switch from the less potent [ala-IL-8](77) to [ser-IL-8](72) correlates with a maturational increase in the neutrophil chemotactic potency of plasma IL-8.	Alanine	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
19232500-4	2009	This isoform switch from the less potent [ala-IL-8](77) to [ser-IL-8](72) correlates with a maturational increase in the neutrophil chemotactic potency of plasma IL-8.	Alanine	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
19232500-4	2009	This isoform switch from the less potent [ala-IL-8](77) to [ser-IL-8](72) correlates with a maturational increase in the neutrophil chemotactic potency of plasma IL-8.	Serine	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
19232500-4	2009	This isoform switch from the less potent [ala-IL-8](77) to [ser-IL-8](72) correlates with a maturational increase in the neutrophil chemotactic potency of plasma IL-8.	Serine	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
19232500-4	2009	This isoform switch from the less potent [ala-IL-8](77) to [ser-IL-8](72) correlates with a maturational increase in the neutrophil chemotactic potency of plasma IL-8.	Serine	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
19232500-5	2009	The emergence of [ser-IL-8](72) as the major isoform is likely due to increased plasma [ala-IL-8](77)-convertase activity and/or changes in the cellular sources of IL-8.	Serine	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
19232500-5	2009	The emergence of [ser-IL-8](72) as the major isoform is likely due to increased plasma [ala-IL-8](77)-convertase activity and/or changes in the cellular sources of IL-8.	Serine	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
19232500-5	2009	The emergence of [ser-IL-8](72) as the major isoform is likely due to increased plasma [ala-IL-8](77)-convertase activity and/or changes in the cellular sources of IL-8.	Serine	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
18759324-8	2009	BaAlFSi particles induced a more marked IL-8 response compared to BaAlSi particles, whereas no significant difference was observed for the IL-6 response.	baalfsi	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
19373630-11	2009	SB203580, PD98059, and wedeloactone decreased IL-8 production stimulated by Na(2)SO(3) (p &lt; 0.01).	wedeloactone	23-35	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
19373630-11	2009	SB203580, PD98059, and wedeloactone decreased IL-8 production stimulated by Na(2)SO(3) (p &lt; 0.01).	sodium sulfite	76-86	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
19373630-12	2009	Salmeterol, fluticasone, and montelukast significantly suppressed IL-8 secretion from sodium sulfite-stimulated A549 cells (p &lt; 0.01).	Salmeterol Xinafoate	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
19373630-12	2009	Salmeterol, fluticasone, and montelukast significantly suppressed IL-8 secretion from sodium sulfite-stimulated A549 cells (p &lt; 0.01).	Fluticasone	12-23	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
19129482-8	2009	Priming with the allergic mediators histamine, IL-4, and most prominently IL-5, augmented the TLR-induced IL-8 and EDN secretion, revealing an ability to sensitize eosinophils for TLR7 and TLR9 activation.	Histamine	36-45	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
19373630-12	2009	Salmeterol, fluticasone, and montelukast significantly suppressed IL-8 secretion from sodium sulfite-stimulated A549 cells (p &lt; 0.01).	montelukast	29-40	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
19373630-12	2009	Salmeterol, fluticasone, and montelukast significantly suppressed IL-8 secretion from sodium sulfite-stimulated A549 cells (p &lt; 0.01).	sodium sulfite	86-100	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
19373630-13	2009	CONCLUSIONS: Sodium sulfite has pro-inflammatory properties in vitro and can induce potent chemotactic factor IL-8 production.	sodium sulfite	13-27	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
19373630-15	2009	Salmeterol, fluticasone, and montelukast all have inhibitory effects on sodium sulfite-induced IL-8 production in A549 cells.	Salmeterol Xinafoate	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
19373630-15	2009	Salmeterol, fluticasone, and montelukast all have inhibitory effects on sodium sulfite-induced IL-8 production in A549 cells.	Fluticasone	12-23	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
19373630-15	2009	Salmeterol, fluticasone, and montelukast all have inhibitory effects on sodium sulfite-induced IL-8 production in A549 cells.	montelukast	29-40	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
19373630-15	2009	Salmeterol, fluticasone, and montelukast all have inhibitory effects on sodium sulfite-induced IL-8 production in A549 cells.	sodium sulfite	72-86	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
19299743-7	2009	Together, IL-8 and PGP account for most of the neutrophil chemoattractant capacity seen in BOS BAL fluid.	N-[4-(Aminosulfonyl)phenyl]-2-Mercaptobenzamide	91-94	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
19299743-8	2009	Using specific neutralizing Abs to both IL-8 and PGP, we demonstrate that PGP is a prominent neutrophil chemoattractant found in BAL fluid from individuals at the time of diagnosis of BOS.	pgp	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
19345795-0	2009	Prostaglandin F(2alpha)-induced interleukin-8 production in human dental pulp cells is associated with MEK/ERK signaling.	Prostaglandins F	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	32-45
19345795-4	2009	IL-1beta and PGF(2alpha) (0.5-10 mumol/L) also induced IL-8 production and mRNA expression in pulp cells.	Prostaglandins F	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
19345795-6	2009	PGF(2alpha)-induced IL-8 production and mRNA expression were inhibited by U0126 (an inhibitor of mitogen-activated protein kinase kinase [MEK1/2]) inhibitor), whereas SQ22536 (an adenylate cyclase inhibitor) enhanced this event.	Prostaglandins F	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
19345795-6	2009	PGF(2alpha)-induced IL-8 production and mRNA expression were inhibited by U0126 (an inhibitor of mitogen-activated protein kinase kinase [MEK1/2]) inhibitor), whereas SQ22536 (an adenylate cyclase inhibitor) enhanced this event.	U 0126	74-79	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
19345795-8	2009	PGF(2alpha)-induced IL-8 production is possibly via activation of MEK/extracellular signal-regulated kinase signaling, but not by activation of adenylate cyclase.	Prostaglandins F	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
19345795-9	2009	IL-1beta and PGF(2alpha) might involve the pathogenesis of pulpal inflammation via induction of IL-8 production.	Prostaglandins F	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
19216880-5	2009	Although the presence of Cu(2+), Co(2+) and Fe(3+) decreased the fluorescence intensity of DBHQ-Ga(3+), the addition of a fluoride ion (NaF) recovered the fluorescence by masking the interfering ions.	dbhq-ga	91-98	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
19107880-0	2009	The vitamin D receptor agonist elocalcitol inhibits IL-8-dependent benign prostatic hyperplasia stromal cell proliferation and inflammatory response by targeting the RhoA/Rho kinase and NF-kappaB pathways.	BXL628	31-42	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
19107880-7	2009	RESULTS: Stimulation of BPH cells with IL-8 activates the calcium-sensitizing RhoA/ROCK pathway, as demonstrated by the increased membrane translocation of RhoA and by phosphorylation of the ROCK substrate myosin phosphatase target subunit 1 (MYPT-1).	Calcium	58-65	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
19107880-9	2009	The VDR agonist elocalcitol significantly inhibits IL-8 production by BPH cells stimulated with inflammatory cytokines, and IL-8-induced proliferation of BPH cells.	BXL628	16-27	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
19107880-10	2009	In addition, elocalcitol inhibits IL-8-induced membrane translocation of RhoA and MYPT-1 phosphorylation in BPH cells, and inhibits dose-dependently their IL-8-dependent invasion.	BXL628	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
19107880-10	2009	In addition, elocalcitol inhibits IL-8-induced membrane translocation of RhoA and MYPT-1 phosphorylation in BPH cells, and inhibits dose-dependently their IL-8-dependent invasion.	BXL628	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
19107880-11	2009	The inhibition induced by elocalcitol of IL-8 production by BPH cells is accompanied by decreased COX-2 expression and PGE(2) production and by arrest of NF-kappaB p65 nuclear translocation, associated with inhibition of the RhoA/ROCK pathway.	BXL628	26-37	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
19107880-11	2009	The inhibition induced by elocalcitol of IL-8 production by BPH cells is accompanied by decreased COX-2 expression and PGE(2) production and by arrest of NF-kappaB p65 nuclear translocation, associated with inhibition of the RhoA/ROCK pathway.	Dinoprostone	119-125	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
21136970-6	2009	Our secretome-based proteomic studies have identified several secreted modulators of sulindac-induced apoptosis action (e.g., Mac-2 binding protein, Alix, 14-3-3 isoforms, profilin-1, calumenin/Cab45 precursors, and the angiogenic/tumor growth factors interleukin 8 (IL-8) and growth related oncogene (GRO-alpha)) that are likely to improve our understanding of the chemopreventitive action of this NSAID in CRC.	Sulindac	85-93	C-X-C motif chemokine ligand 8	Homo sapiens	252-265
19216880-5	2009	Although the presence of Cu(2+), Co(2+) and Fe(3+) decreased the fluorescence intensity of DBHQ-Ga(3+), the addition of a fluoride ion (NaF) recovered the fluorescence by masking the interfering ions.	Fluorides	122-130	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
19135383-5	2009	We also found that IL-1beta-induced release of IL-8 from MH7A cells was completely blocked by pretreatment with the (IL-8) inhibitor Bay11-7085, indicating that activation of NF-kappaB signaling plays an important role in the secretion of IL-8.	BAY 11-7085	133-143	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
19038492-2	2009	Recent reports show that phosphorylation of p65 at serine 276 regulates only a subset of genes, such as those encoding IL-6, IL-8, Gro-beta, and ICAM-1.	Serine	51-57	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
19135383-4	2009	We found that LPIL exerted a smaller effect on gene transcription than Dex; however, IL-1beta-inducible target genes such as the CXCL type chemokines IL-8, IL-1beta and IL-6 were all clearly suppressed by LPIL to the same degree as by Dex.	lpil	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
19135383-5	2009	We also found that IL-1beta-induced release of IL-8 from MH7A cells was completely blocked by pretreatment with the (IL-8) inhibitor Bay11-7085, indicating that activation of NF-kappaB signaling plays an important role in the secretion of IL-8.	BAY 11-7085	133-143	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
19135383-5	2009	We also found that IL-1beta-induced release of IL-8 from MH7A cells was completely blocked by pretreatment with the (IL-8) inhibitor Bay11-7085, indicating that activation of NF-kappaB signaling plays an important role in the secretion of IL-8.	BAY 11-7085	133-143	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
19135383-7	2009	Thus LPIL likely exerts its anti-inflammatory effects by inhibiting the release of the inflammatory chemokine IL-8.	lpil	5-9	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
18758684-5	2009	The level of VEGF, IL-8 and Angiogenin were increased in pioglitazone than rosiglitazone group.	Pioglitazone	57-69	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
19247018-11	2009	The EPA group had a significantly (P &lt; 0.05) attenuated stress response for TNFalpha, IL-10, and IL-8 compared with the standard group.	Eicosapentaenoic Acid	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
19120068-11	2009	Airway cells that were primed with alcohol produced nearly twice as much IL-8 in response to 40 ng of peptidoglycan than naive cells.	Alcohols	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
19112099-9	2009	The mRNA levels of the proinflammatory cytokines interleukin (IL)-1beta and IL-8 were also lower (P &lt; 0.05) in ethanol-exposed fetuses compared with controls.	Ethanol	114-121	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
19112101-0	2009	Role of acylglycerol kinase in LPA-induced IL-8 secretion and transactivation of epidermal growth factor-receptor in human bronchial epithelial cells.	lysophosphatidic acid	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
19112101-5	2009	Overexpression of lentiviral AGK wild type increased intracellular LPA production ( approximately 1.8-fold), enhanced LPA-mediated IL-8 secretion, and stimulated tyrosine phosphorylation epidermal growth factor-receptor (EGF-R).	lysophosphatidic acid	118-121	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
19112101-6	2009	Furthermore, downregulation of native AGK by AGK small interfering RNA decreased intracellular LPA levels ( approximately 2-fold) and attenuated LPA-induced p38 MAPK, JNK, and NF-kappaB activation, tyrosine phosphorylation of EGF-R, and IL-8 secretion.	lysophosphatidic acid	145-148	C-X-C motif chemokine ligand 8	Homo sapiens	237-241
19112101-7	2009	These results suggest that native AGK regulates LPA-mediated IL-8 secretion involving MAPKs, NF-kappaB, and transactivation of EGF-R.	lysophosphatidic acid	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
19220840-4	2009	BFT-activated nuclear factor-kappaB (NF-kappaB) signals in HT-29 cells and pretreatment with eupatilin suppressed NF-kappaB activation that resulted in the significant inhibition of IL-8 and cyclo-oxygenase-2 expression.	eupatilin	93-102	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
19016779-0	2009	Staphylococcus epidermidis polysaccharide intercellular adhesin induces IL-8 expression in human astrocytes via a mechanism involving TLR2.	Polysaccharides	27-41	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
19338650-12	2009	The average IL-8 induction was 1330 pg/mL for dupA-positive isolates and 1378 pg/mL for dupA-negative isolates.	DUPA	46-50	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
19338650-12	2009	The average IL-8 induction was 1330 pg/mL for dupA-positive isolates and 1378 pg/mL for dupA-negative isolates.	DUPA	88-92	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
19385035-3	2009	The present study was undertaken using the established co-culture system of Caco-2 epithelial cells with lymphocytes of Peyer"s patch to investigate the expression of IL-8 and IL-6 cytokines and cytokine receptors in the co-culture system after challenge with Shigella F2a-12 lipopolysaccharide (LPS).	12 lipopolysaccharide	273-294	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
19220840-7	2009	In addition, herbimycin A, a specific inhibitor of heat shock protein 90 (Hsp90), decreased the BFT-induced activation of IKK and NF-kappaB, suggesting that Hsp90 is associated with a pathway of IKK-NF-kappaB-IL-8/cyclo-oxygenase-2 gene signalling.	herbimycin	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
19029040-12	2009	CONCLUSIONS: ATPgammaS, UTP, and UDP stimulate both basal and TNFalpha-induced IL-8 secretion in RPE cells through an ERK 1/2-dependent pathway.	Uridine Diphosphate	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
19212662-9	2009	Moreover, remarkable increases in G-CSF and IL-8 secretions by 8-Br-cAMP-stimulated ESCs during decidualization were completely inhibited by cotreatment with danazol.	8-Bromo Cyclic Adenosine Monophosphate	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
19212662-9	2009	Moreover, remarkable increases in G-CSF and IL-8 secretions by 8-Br-cAMP-stimulated ESCs during decidualization were completely inhibited by cotreatment with danazol.	Danazol	158-165	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
19279966-1	2009	AIM: To compare the plaque inhibition efficacy of a sodium fluoride/potassium nitrate (NaF/KNO3 with 1450 ppm F) test dentifrice to a 0.454% stannous fluoride/sodium hexametaphosphate/sodium fluoride positive control dentifrice (SnF2/SHMP with 1450 ppm F).	Sodium Fluoride	52-67	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
19029040-2	2009	This investigation focused on whether extracellular nucleotides could contribute to this activation, and the effects of ATPgammaS, UTP, and UDP on the production of IL-8 by RPE cells was studied in relation to their expression of functional P2Y receptors.	adenosine 5'-O-(3-thiotriphosphate)	120-129	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
19029040-2	2009	This investigation focused on whether extracellular nucleotides could contribute to this activation, and the effects of ATPgammaS, UTP, and UDP on the production of IL-8 by RPE cells was studied in relation to their expression of functional P2Y receptors.	Uridine Triphosphate	131-134	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
19029040-2	2009	This investigation focused on whether extracellular nucleotides could contribute to this activation, and the effects of ATPgammaS, UTP, and UDP on the production of IL-8 by RPE cells was studied in relation to their expression of functional P2Y receptors.	Uridine Diphosphate	140-143	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
19029040-7	2009	RESULTS: Stimulation of ARPE-19 cells with ATPgammaS, UTP, and UDP induced IL-8 gene transcription and protein secretion.	Uridine Triphosphate	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
19029040-7	2009	RESULTS: Stimulation of ARPE-19 cells with ATPgammaS, UTP, and UDP induced IL-8 gene transcription and protein secretion.	Uridine Diphosphate	63-66	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
19029040-8	2009	TNFalpha induction of IL-8 secretion was also increased by ATPgammaS, UTP, and UDP.	adenosine 5'-O-(3-thiotriphosphate)	59-68	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
19029040-8	2009	TNFalpha induction of IL-8 secretion was also increased by ATPgammaS, UTP, and UDP.	Uridine Triphosphate	70-73	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
19029040-8	2009	TNFalpha induction of IL-8 secretion was also increased by ATPgammaS, UTP, and UDP.	Uridine Diphosphate	79-82	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
19029040-9	2009	Nucleotide induction of IL-8 production was blocked by PD98059, and all nucleotides stimulated ERK 1/2 phosphorylation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	55-62	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
19029040-12	2009	CONCLUSIONS: ATPgammaS, UTP, and UDP stimulate both basal and TNFalpha-induced IL-8 secretion in RPE cells through an ERK 1/2-dependent pathway.	adenosine 5'-O-(3-thiotriphosphate)	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
19029040-12	2009	CONCLUSIONS: ATPgammaS, UTP, and UDP stimulate both basal and TNFalpha-induced IL-8 secretion in RPE cells through an ERK 1/2-dependent pathway.	Uridine Triphosphate	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
18685861-5	2009	Systolic blood pressure was markedly increased and circulating levels of IL-1beta, IL-1Ra, and IL-8 were significantly reduced during a 2-h interval of PMX.	(+)-xylariamide A	152-155	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
19052917-8	2009	We found that the incorporation of the detergent solubilized CXCR1 into phospholipid vesicles in the presence of Gi/Go proteins is required for the reconstitution of (125)I-IL-8 binding.	Phospholipids	72-84	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
19010653-9	2009	Quercetin significantly decreased ex vivo LPS-induced TNFalpha- and IL-8 production in a concentration-dependent manner in both groups.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
19103208-5	2009	The STAT1 inhibitor, fludarabine, prevented gp120-induced IL-6 and IL-8 secretion.	fludarabine	21-32	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
19103208-6	2009	Inhibitors of STAT1, mitogen activated protein kinase kinase (MEK) (PD98059), and phosphatidyl inositol 3 kinase (PI3K) (LY294002), blocked gp120-induced STAT1 activation and significantly diminished IL-8-, IL-6-, and gp120-induced monocyte adhesion and migration across in vitro BBB models.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
19179025-9	2009	Serum concentrations of IL-8, IL-10, macrophage inflammatory protein (MIP)-1beta and monocyte chemoattractant protein-1 in women treated with paroxetine decreased significantly.	Paroxetine	142-152	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
19328934-7	2009	CONCLUSION: Systemic inflammation and IL-8-mediated neutrophilic airway inflammation seem to be associated after LTx.	Leukotriene C4	113-116	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
19146941-5	2009	RESULTS: HaCaT cells induced the pro-inflammatory cytokines, interleukin-8 (IL-8) and/or interleukin-6 (IL-6) expressions after treatment with polyI:C or PGN.	Poly I-C	143-150	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
19146941-5	2009	RESULTS: HaCaT cells induced the pro-inflammatory cytokines, interleukin-8 (IL-8) and/or interleukin-6 (IL-6) expressions after treatment with polyI:C or PGN.	Poly I-C	143-150	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
19138665-5	2009	In terms of its functional aspect, we observed that alpha-iso-cubebene strongly stimulated CXCL8 production in human neutrophils.	alpha-iso-cubebene	52-70	C-X-C motif chemokine ligand 8	Homo sapiens	91-96
19138665-6	2009	Also, alpha-iso-cubebene-induced CXCL8 production was almost completely inhibited by the calcium chelator, EGTA, thus highlighting the role of calcium signaling in the process.	alpha-iso-cubebene	6-24	C-X-C motif chemokine ligand 8	Homo sapiens	33-38
19138665-6	2009	Also, alpha-iso-cubebene-induced CXCL8 production was almost completely inhibited by the calcium chelator, EGTA, thus highlighting the role of calcium signaling in the process.	Calcium	89-96	C-X-C motif chemokine ligand 8	Homo sapiens	33-38
19179025-12	2009	The action of paroxetine may also be associated with decreases in IL-8, IL-10, MIP-1beta.	Paroxetine	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
19138665-6	2009	Also, alpha-iso-cubebene-induced CXCL8 production was almost completely inhibited by the calcium chelator, EGTA, thus highlighting the role of calcium signaling in the process.	Egtazic Acid	107-111	C-X-C motif chemokine ligand 8	Homo sapiens	33-38
19138665-6	2009	Also, alpha-iso-cubebene-induced CXCL8 production was almost completely inhibited by the calcium chelator, EGTA, thus highlighting the role of calcium signaling in the process.	Calcium	143-150	C-X-C motif chemokine ligand 8	Homo sapiens	33-38
19121628-0	2009	ROS and NF-kappaB are involved in upregulation of IL-8 in A549 cells exposed to multi-walled carbon nanotubes.	Reactive Oxygen Species	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
19138665-7	2009	Taken together, our results demonstrate that alpha-iso-cubebene is a novel natural compound which stimulates intracellular calcium signaling and CXCL8 production.	alpha-iso-cubebene	45-63	C-X-C motif chemokine ligand 8	Homo sapiens	145-150
19011150-7	2009	MEASUREMENTS AND MAIN RESULTS: Oxidants evoked the release of CXCL8 from monocytes/macrophages; this was abrogated by pretreatment with N-acetylcysteine or binding antibodies to TLR2 and was associated with the rapid phosphorylation of IL-1 receptor-associated kinase 1.	Acetylcysteine	136-152	C-X-C motif chemokine ligand 8	Homo sapiens	62-67
19121628-0	2009	ROS and NF-kappaB are involved in upregulation of IL-8 in A549 cells exposed to multi-walled carbon nanotubes.	Carbon	93-99	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
19221248-8	2009	RESULTS: Curcumin treatment resulted in dose-dependent inhibition of IL-6 and IL-8 in all cell lines.	Curcumin	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
19143560-10	2009	With sodium fluoride (NaF) as the subphase electrolyte, it is demonstrated that sodium exhibits a weak complexation-type interaction with the zwitterionic lipids.	Sodium Fluoride	5-20	C-X-C motif chemokine ligand 8	Homo sapiens	22-25
19143560-10	2009	With sodium fluoride (NaF) as the subphase electrolyte, it is demonstrated that sodium exhibits a weak complexation-type interaction with the zwitterionic lipids.	Sodium	5-11	C-X-C motif chemokine ligand 8	Homo sapiens	22-25
19143561-7	2009	In the present paper, we first prove that the experimental results for sodium fluoride (NaF) can be fitted by a model that is based on simultaneous complexation of sodium ions with up to three lipid molecules, as suggested by recent molecular dynamics simulations.	Sodium Fluoride	71-86	C-X-C motif chemokine ligand 8	Homo sapiens	88-91
19143561-7	2009	In the present paper, we first prove that the experimental results for sodium fluoride (NaF) can be fitted by a model that is based on simultaneous complexation of sodium ions with up to three lipid molecules, as suggested by recent molecular dynamics simulations.	Sodium	71-77	C-X-C motif chemokine ligand 8	Homo sapiens	88-91
19074641-6	2009	Curcumin, as well as inhibitors of NF-kappaB (SN-50), PKC (chelerythrine), and p44/42 MAPK (PD-098059) abolished the acid-induced expression of IL-6 and IL-8.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
19074641-7	2009	The JNK inhibitor SP-600125 blocked expression/secretion of IL-6 but only partially attenuated IL-8 expression.	pyrazolanthrone	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
19074641-8	2009	The p38 MAPK inhibitor SB-203580 did not inhibit IL-6 expression but exerted a stronger inhibitory effect on IL-8 expression.	SB 203580	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
19074641-9	2009	Together, these data demonstrate that 1) acid is a potent inducer of IL-6 and IL-8 production in HET-1A cells; 2) MAPK and PKC signaling play a key regulatory role in acid-mediated IL-6 and IL-8 expression via NF-kappaB activation; and 3) the anti-inflammatory plant compound curcumin inhibits esophageal activation in response to acid.	Curcumin	276-284	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
19221248-1	2009	OBJECTIVES: To evaluate the effect of curcumin on production of interleukin 6 (IL-6) and 8 (IL-8) in head and neck squamous cell carcinoma (HNSCC) cell lines and to determine the mechanism by which these effects are modulated.	Curcumin	38-46	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
19221248-7	2009	MAIN OUTCOME MEASURES: Reverse transcription-polymerase chain reaction was performed to determine the effect of curcumin on the expression of IL-6 and IL-8.	Curcumin	112-120	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
19221248-10	2009	Curcumin treatment resulted in inhibition of IKK activity and inhibition of IL-6 and IL-8 expression.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
18599066-3	2009	Palmitate induced secretion and mRNA expression of TNF-alpha, IL-8 and IL-1 beta, and enhanced lipopolysaccharide (LPS)-induced IL-1 beta secretion.	Palmitates	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
19221248-11	2009	CONCLUSIONS: Curcumin significantly reduces IL-6 and IL-8 levels in HNSCC cell lines.	Curcumin	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
18599066-9	2009	Knockdown of MyD88 reduced the palmitate-induced IL-8, but not TNF-alpha or IL-1 beta secretion.	Palmitates	31-40	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
18977028-7	2009	Moreover, HL60-PMN cells secreted the potent neutrophil chemokine IL-8, also known as CXCL8, when exposed to chitosan and IL-8 levels increased with N-acetylation, and migration was inhibited by anti-IL-8 antibodies.	Chitosan	109-117	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
18977028-7	2009	Moreover, HL60-PMN cells secreted the potent neutrophil chemokine IL-8, also known as CXCL8, when exposed to chitosan and IL-8 levels increased with N-acetylation, and migration was inhibited by anti-IL-8 antibodies.	Chitosan	109-117	C-X-C motif chemokine ligand 8	Homo sapiens	86-91
19208784-6	2009	Thrombin, vascular endothelial growth factor and interleukin-8 synergistically augment angiogenesis in a milieu of reactive oxygen species-induced endothelial cell activation.	Reactive Oxygen Species	115-138	C-X-C motif chemokine ligand 8	Homo sapiens	49-62
19175605-0	2009	Prostaglandin E(2) couples through EP(4) prostanoid receptors to induce IL-8 production in human colonic epithelial cell lines.	Prostaglandins E	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
19175605-4	2009	The aim of this study was to identify the role of the EP(2) and EP(4) receptor subtype(s) on two human colonic epithelial cell lines (Caco-2 and T84), in regulating PGE(2)-induced IL-8 production.	Dinoprostone	165-171	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
19175605-8	2009	KEY RESULTS: PGE(2) had the highest affinity for the EP(4) receptor subtype and promoted a robust stimulation of cAMP-dependent IL-8 synthesis.	Prostaglandins E	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
19175605-8	2009	KEY RESULTS: PGE(2) had the highest affinity for the EP(4) receptor subtype and promoted a robust stimulation of cAMP-dependent IL-8 synthesis.	Cyclic AMP	113-117	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
19175605-10	2009	CONCLUSIONS AND IMPLICATIONS: These findings suggest that initiation and progression of colonic inflammation induced by IL-8 could be mediated, at least in part, by PGE(2) acting via the EP(4) receptor subtype.	Prostaglandins E	165-168	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
19158563-8	2009	Tear IL-6 and IL-8 levels were significantly higher in patients with CCh than in controls (P &lt;or= 0.001).	1-acetyl-2-(coumariniminecarboxamide-3-yl)hydrazine	69-72	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
18936140-14	2009	Inhibition of NF-kappaB with BAY 11-7082 reduced IL-8 but not VEGF induction.	3-(4-methylphenylsulfonyl)-2-propenenitrile	29-40	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
19015376-5	2009	The rapid and strong release of reactive oxygen species and preformed intragranular mediators (myeloperoxidase and IL-8) is followed by a later TNF-alpha, IL-1beta, and IL-8 synthesis.	Reactive Oxygen Species	32-55	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
19015376-5	2009	The rapid and strong release of reactive oxygen species and preformed intragranular mediators (myeloperoxidase and IL-8) is followed by a later TNF-alpha, IL-1beta, and IL-8 synthesis.	Reactive Oxygen Species	32-55	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
19449765-16	2009	In addition, NO2 had a significant effect on bronchial reactivity and on the amount of interleukin-8 (IL-8) in induced sputum; it also modified the UFP effect on EBC pH and the EC effect on exhaled nitric oxide (eNO).	Nitrogen Dioxide	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	87-100
19449765-16	2009	In addition, NO2 had a significant effect on bronchial reactivity and on the amount of interleukin-8 (IL-8) in induced sputum; it also modified the UFP effect on EBC pH and the EC effect on exhaled nitric oxide (eNO).	Nitrogen Dioxide	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
18996182-0	2009	Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression.	Norepinephrine	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
19138532-3	2009	The results revealed that DEX nonspecifically and dose-dependently inhibited the production of 12 cytokines (IL-2, IFN-gamma, TNF-alpha, IL-8, IL-1beta, IL-17, IL-4, IL-5, IL-6, IL-10, IL-13, and G-CSF).	Dexamethasone	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
18776171-3	2009	RSV blocked 10,12 CLA induction of the inflammatory response by preventing activation of extracellular signal-related kinase and induction of inflammatory gene expression (i.e., IL-6, IL-8, IL-1beta) within 12 h. Similarly, RSV suppressed 10,12 CLA-mediated activation of the inflammatory prostaglandin pathway involving phospholipase A(2), cyclooxygenase-2, and PGF(2alpha).	Resveratrol	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
19262007-5	2009	Our results demonstrate that a combination of insulin and glutamine are significantly more effective in reducing the expression of IL-8, TNF-alpha and HO-1 than insulin or glutamine alone.	Glutamine	58-67	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
19262007-5	2009	Our results demonstrate that a combination of insulin and glutamine are significantly more effective in reducing the expression of IL-8, TNF-alpha and HO-1 than insulin or glutamine alone.	Glutamine	172-181	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
19229322-5	2009	Our present findings demonstrate a rapid and HMB-PP-dependent crosstalk between Vgamma9/Vdelta2 T cells and autologous monocytes that results in the immediate production of inflammatory mediators including the cytokines interleukin (IL)-6, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and oncostatin M (OSM); the chemokines CCL2, CXCL8, and CXCL10; and TNF-related apoptosis-inducing ligand (TRAIL).	4-hydroxy-3-methylbut-2-enyl pyrophosphate	45-51	C-X-C motif chemokine ligand 8	Homo sapiens	344-349
19657754-9	2009	Secretion of IL-8 from cultured cervical fibroblasts was significantly increased after treatment with low molecular weight heparin.	Heparin	123-130	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
19028451-5	2009	IL-8 up-regulation in response to HSP90 was also attenuated by IkappaB, rasveratrol, curcumin, diphenyleneiodium, N-acetylcystein, U0126, and SB202190.	rasveratrol	72-83	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19028451-5	2009	IL-8 up-regulation in response to HSP90 was also attenuated by IkappaB, rasveratrol, curcumin, diphenyleneiodium, N-acetylcystein, U0126, and SB202190.	Curcumin	85-93	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19028451-5	2009	IL-8 up-regulation in response to HSP90 was also attenuated by IkappaB, rasveratrol, curcumin, diphenyleneiodium, N-acetylcystein, U0126, and SB202190.	diphenyleneiodium	95-112	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19028451-5	2009	IL-8 up-regulation in response to HSP90 was also attenuated by IkappaB, rasveratrol, curcumin, diphenyleneiodium, N-acetylcystein, U0126, and SB202190.	N-Acetyl-L-cysteine	114-129	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19028451-5	2009	IL-8 up-regulation in response to HSP90 was also attenuated by IkappaB, rasveratrol, curcumin, diphenyleneiodium, N-acetylcystein, U0126, and SB202190.	U 0126	131-136	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19028451-5	2009	IL-8 up-regulation in response to HSP90 was also attenuated by IkappaB, rasveratrol, curcumin, diphenyleneiodium, N-acetylcystein, U0126, and SB202190.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	142-150	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19034732-12	2009	The levels of IL-8 were higher following treatment with misoprostol compared to IMN and controls.	Misoprostol	56-67	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
19239157-6	2009	Taurine also inhibited the TNF-alpha-induced secretion of IL-8 (a human homologue of MIP-2) from human intestinal epithelial Caco-2 cells.	Taurine	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
19567187-0	2009	[Effects of erythromycin on the synthesis of interleukin-8 and gamma-glutamylcysteine synthetase induced by 4-hydroxynonenal in the bronchial epithelial cells].	Erythromycin	12-24	C-X-C motif chemokine ligand 8	Homo sapiens	45-58
19567187-0	2009	[Effects of erythromycin on the synthesis of interleukin-8 and gamma-glutamylcysteine synthetase induced by 4-hydroxynonenal in the bronchial epithelial cells].	4-hydroxy-2-nonenal	108-124	C-X-C motif chemokine ligand 8	Homo sapiens	45-58
19567187-1	2009	OBJECTIVE: This study was to explore the role of erythromycin on the synthesis of interleukin-8 (IL-8) and gamma-GCS treated by 4-hydroxynonenal (4-HNE) in bronchial epithelial cells (16-HBE).	Erythromycin	49-61	C-X-C motif chemokine ligand 8	Homo sapiens	82-95
19567187-1	2009	OBJECTIVE: This study was to explore the role of erythromycin on the synthesis of interleukin-8 (IL-8) and gamma-GCS treated by 4-hydroxynonenal (4-HNE) in bronchial epithelial cells (16-HBE).	Erythromycin	49-61	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
19567187-1	2009	OBJECTIVE: This study was to explore the role of erythromycin on the synthesis of interleukin-8 (IL-8) and gamma-GCS treated by 4-hydroxynonenal (4-HNE) in bronchial epithelial cells (16-HBE).	4-hydroxy-2-nonenal	128-144	C-X-C motif chemokine ligand 8	Homo sapiens	82-95
19567187-5	2009	(3) The effects of PD98059 and erythromycin on the expression of gamma-GCS, gamma-GCS mRNA, IL-8 and erythromycin on AP-1 combining activity by the 4-HNE were all detected.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
19567187-5	2009	(3) The effects of PD98059 and erythromycin on the expression of gamma-GCS, gamma-GCS mRNA, IL-8 and erythromycin on AP-1 combining activity by the 4-HNE were all detected.	Erythromycin	31-43	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
19567187-13	2009	Erythromycin could inhibit the synthesis of IL-8 by blocking AP-1 pathway.	Erythromycin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
19098936-7	2009	Additionally, 15d-PGJ2 at 2.5 and 5 micromol/L and TGL at 2.5 micromol/L inhibited TGF-beta1-induced expression of IL-8.	15-deoxyprostaglandin J2	14-22	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
19098936-7	2009	Additionally, 15d-PGJ2 at 2.5 and 5 micromol/L and TGL at 2.5 micromol/L inhibited TGF-beta1-induced expression of IL-8.	Troglitazone	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
19657754-11	2009	CONCLUSIONS: A possible underlying mechanism for the shortened labor time after low molecular weight heparin treatment is enhanced myometrial contractility and an increased IL-8 secretion in cervical fibroblast, mimicking the final cervical ripening in vivo.	Heparin	101-108	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
19938227-7	2009	Furthermore, resveratrol inhibited extracellular signal-regulated kinase (ERK) and p38 MAPK phosphorylation, IkappaBalpha degradation, NF-kappaB activation and cyclooxygenase (COX)-2 expression, which suggest that resveratrol inhibits IL-8 secretion by blocking MAPK phosphorylation and NF-kappaB activation.	Resveratrol	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	235-239
19938227-0	2009	Anti-inflammatory effect of resveratrol by inhibition of IL-8 production in LPS-induced THP-1 cells.	Resveratrol	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
19938227-3	2009	To gain insight into the biological effects of resveratrol, we examined its influence on LPS-induced IL-8 production in the human monocytic cell line, THP-1.	Resveratrol	47-58	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
19204390-0	2009	Fluoride retention in proximal plaque and saliva using two NaF dentifrices containing 5,000 and 1,450 ppm F with and without water rinsing.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	59-62
19938227-6	2009	Resveratrol inhibited LPS-induced IL-8 production in a dose-dependent manner.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
18635816-10	2009	The reducing agent N-acetyl-cysteine decreases IL8 message and promoter H4 acetylation to non-CF levels, suggesting that oxidative stress contributes to IL8 expression in these models.	Acetylcysteine	19-36	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
18635816-10	2009	The reducing agent N-acetyl-cysteine decreases IL8 message and promoter H4 acetylation to non-CF levels, suggesting that oxidative stress contributes to IL8 expression in these models.	Acetylcysteine	19-36	C-X-C motif chemokine ligand 8	Homo sapiens	153-156
19526316-7	2009	HGF-induced up-regulations of Egr-1, VEGF, and IL-8 were inhibited by the pretreatment with an MEK inhibitor, PD098059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	110-118	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
19158539-8	2009	In addition, in patients with FM, IL-8 serum level correlated with nicotine consumption (r=0.471, P=0.042).	Nicotine	67-75	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
18996370-4	2009	Microarray analysis using a tetracycline-inducible LMX1B expression system in HeLa cells revealed that a subset of NF-kappaB target genes, including IL-6 and IL-8, are upregulated in LMX1B-expressing cells.	Tetracycline	28-40	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
18663553-6	2009	In the case of IL-8, its serum levels significantly diminished after 6 months of therapy with leflunomide (p &lt; 0.01) and remained stable to the end of the study.	Leflunomide	94-105	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
20003352-12	2009	A significant inverse association was found between IL-6, IL-8 and PaO2 in critical patients.	pao2	67-71	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
19439970-5	2009	RESULTS: A significant correlation between norepinephrine support and IL-6 plasma concentrations was shown at the separation from CPB (k = 0.742) and 12 h after it (k = 0.801) as well as between norepinephrine support and IL-8 concentrations 12 h after the separation from CPB.	Norepinephrine	43-57	C-X-C motif chemokine ligand 8	Homo sapiens	222-226
19246914-4	2009	Additionally, in light of the stimulatory effect of homocysteine on the production of IL-8, we also sought to determine whether the methylenetetrahydrofolate reductase (MTHFR) gene 677 C/T variant, a genetic modifier of the serum homocysteine level, may interact with the IL-8 -251 polymorphism in determining the AD risk.	Homocysteine	52-64	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
19551959-4	2009	The treatment with biltricid allow to decrease the TNF alpha, IL-1beta, IL-8 levels and to increase IL-4 level, especially in patients with combination of chronic opisthorhosis and Helicobacter pylori associated gastritis.	biltricid	19-28	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
19053024-0	2009	Selective association of plasma non-esterified fatty acid species with circulating interleukin-8 concentrations in humans.	Fatty Acids	47-57	C-X-C motif chemokine ligand 8	Homo sapiens	83-96
19053024-7	2009	The correlations of myristate, oleate, and the sum of all omega3-polyunsaturated NEFA with interleukin-8 were independent of plasma tumour necrosis factor-alpha and overall adiposity.	Myristic Acid	20-29	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
19053024-8	2009	Our data demonstrate close and selective associations of oleate, myristate, and omega3-polyunsaturated NEFA with plasma concentrations of the pro-inflammatory chemokine interleukin-8.	omega3-polyunsaturated nefa	80-107	C-X-C motif chemokine ligand 8	Homo sapiens	169-182
19439980-9	2009	RESULTS: Budesonide inhibited the release of TNF-alpha, IL-6 and IL-8 from sPLA(2)-stimulated macrophages in a concentration-dependent manner.	Budesonide	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
19053024-7	2009	The correlations of myristate, oleate, and the sum of all omega3-polyunsaturated NEFA with interleukin-8 were independent of plasma tumour necrosis factor-alpha and overall adiposity.	polyunsaturated nefa	65-85	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
19053024-8	2009	Our data demonstrate close and selective associations of oleate, myristate, and omega3-polyunsaturated NEFA with plasma concentrations of the pro-inflammatory chemokine interleukin-8.	Oleic Acid	57-63	C-X-C motif chemokine ligand 8	Homo sapiens	169-182
19053024-8	2009	Our data demonstrate close and selective associations of oleate, myristate, and omega3-polyunsaturated NEFA with plasma concentrations of the pro-inflammatory chemokine interleukin-8.	Myristic Acid	65-74	C-X-C motif chemokine ligand 8	Homo sapiens	169-182
19027816-6	2009	Resveratrol treatment effectively prevented increased production of intracellular reactive oxygen species (iROS) and inflammatory markers (IL1alpha, IL6, IL8, and ELAM-1), and reduced expression of the senescence markers sa-beta-gal, lipofuscin, and accumulation of carbonylated proteins.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	154-157
19038366-0	2009	Ghrelin inhibits interleukin-8 production induced by hydrogen peroxide in A549 cells via NF-kappaB pathway.	Ghrelin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	17-30
19038366-0	2009	Ghrelin inhibits interleukin-8 production induced by hydrogen peroxide in A549 cells via NF-kappaB pathway.	Hydrogen Peroxide	53-70	C-X-C motif chemokine ligand 8	Homo sapiens	17-30
19038366-3	2009	We examined whether ghrelin inhibits the proinflammatory cytokine interleukin-8 production induced by hydrogen peroxide (H2O2) in human lung epithelia cell line A549 and which mechanism is related with this effect of ghrelin.	Ghrelin	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
19038366-3	2009	We examined whether ghrelin inhibits the proinflammatory cytokine interleukin-8 production induced by hydrogen peroxide (H2O2) in human lung epithelia cell line A549 and which mechanism is related with this effect of ghrelin.	Hydrogen Peroxide	102-119	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
19038366-3	2009	We examined whether ghrelin inhibits the proinflammatory cytokine interleukin-8 production induced by hydrogen peroxide (H2O2) in human lung epithelia cell line A549 and which mechanism is related with this effect of ghrelin.	Hydrogen Peroxide	121-125	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
19038366-7	2009	Cells treated with H2O2 (50 microM) exhibited significantly higher interleukin-8 production and ghrelin receptor mRNA expression compared with cells treated with vehicle alone (P &lt; 0.05).	Hydrogen Peroxide	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
19038366-8	2009	Ghrelin inhibited H2O2-induced interleukin-8 production by A549 at both mRNA and protein levels in a concentration-dependent manner (P &lt; 0.05).	Ghrelin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	31-44
19038366-8	2009	Ghrelin inhibited H2O2-induced interleukin-8 production by A549 at both mRNA and protein levels in a concentration-dependent manner (P &lt; 0.05).	Hydrogen Peroxide	18-22	C-X-C motif chemokine ligand 8	Homo sapiens	31-44
19038366-10	2009	Together, these results suggest that ghrelin inhibits H2O2-induced interleukin-8 production in A549 cells by targeting on NF-kappaB pathway, but not by directly scavenging intracellular ROS.	Ghrelin	37-44	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
19038366-10	2009	Together, these results suggest that ghrelin inhibits H2O2-induced interleukin-8 production in A549 cells by targeting on NF-kappaB pathway, but not by directly scavenging intracellular ROS.	Hydrogen Peroxide	54-58	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
19494510-12	2009	CONCLUSION: These data showed that 15d-PGJ2 is a potent inducer of IL-8 and GM-CSF production through ERK1/2 kinase activation, but this is independent of CRTH2 or PPARgamma activation.	15-deoxy-delta(12,14)-prostaglandin J2	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
19494510-0	2009	15-Deoxy-Delta(12,14)-prostaglandin J2 induces IL-8 and GM-CSF in a human airway epithelial cell line (NCI-H292).	15-deoxy-delta(12,14)-prostaglandin J2	0-38	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
19494510-4	2009	Although our studies have shown that PGD2 (metabolic precursor of 15d-PGJ2) induces IL-8 and GM-CSF production, the role of 15d-PGJ2 (metabolite of PGD2) is unknown in human bronchial epithelial cells.	Prostaglandin D2	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
19494510-4	2009	Although our studies have shown that PGD2 (metabolic precursor of 15d-PGJ2) induces IL-8 and GM-CSF production, the role of 15d-PGJ2 (metabolite of PGD2) is unknown in human bronchial epithelial cells.	15-deoxy-delta(12,14)-prostaglandin J2	66-74	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
19494510-8	2009	RESULTS: We demonstrated that 15d-PGJ2 induced production of IL-8 and GM-CSF from NCI-H292.	15-deoxy-delta(12,14)-prostaglandin J2	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
20131677-8	2009	The increase in Sa and bulk tissue loss caused by an erosive challenge followed by brushing was markedly reduced by pre-treatment with sodium fluoride (NaF) in a concentration-dependent manner.	sa	16-18	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
20069129-0	2009	Reduction of monocyte chemoattractant protein-1 and interleukin-8 levels by ticlopidine in TNF-alpha stimulated human umbilical vein endothelial cells.	Ticlopidine	76-87	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
19489187-5	2009	The study also showed that this new arginine toothpaste provided significantly greater reductions (p &lt; 0.05) in dentin hypersensitivity in response to tactile (16.2%, 22.4%, and 21.4%) and air blast (16.2%, 29.2%, and 63.4%) stimuli than the benchmark commercial toothpaste containing 2% potassium ion and 1450 ppm NaF in a silica base, after two, four, and eight weeks of product use, respectively.	Arginine	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	318-321
19489188-5	2009	The study also showed that this new arginine toothpaste provided significantly greater reductions (p &lt; 0.05) in dentin hypersensitivity in response to tactile (37.0%, 30.0%, and 12.2%) and air blast (23.9%, 32.0%, and 29.3%) stimuli than the commercial sensitive toothpaste containing 2% potassium ion and 1450 ppm fluoride as NaF in a silica base, after two weeks, four weeks, and eight weeks of product use, respectively.	Arginine	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	330-333
20069129-8	2009	These results suggest that ticlopidine decreased TNF-alpha induced MCP-1, IL-8, and VCAM-1 levels in HUVECs, and monocyte adhesion.	Ticlopidine	27-38	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
19591336-7	2009	RESULTS: A good fluoride dose-response was established for EFU and REM, with NaF delivering greater EFU and REM than NaF-675, which was superior to NaF-0 (p &lt; 0.05).	Fluorides	16-24	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
19591336-12	2009	The new dentifrice NaF showed superior predicted anticaries potential compared to the two commercial dentifrices AmF and SnNaF in this model, which demonstrates the importance of fluoride compound and formulation excipients on driving anticaries potential in vitro.	Fluorides	179-187	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
20131677-8	2009	The increase in Sa and bulk tissue loss caused by an erosive challenge followed by brushing was markedly reduced by pre-treatment with sodium fluoride (NaF) in a concentration-dependent manner.	Sodium Fluoride	135-150	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
20131677-12	2009	CONCLUSION: The utility of NaF, whether delivered from simple solution or toothpaste, to reduce citric acid-mediated surface roughening and bulk tissue loss has been clearly demonstrated.	Citric Acid	96-107	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
18690522-0	2009	Roles of reactive oxygen species in CXCL8 and CCL2 expression in response to the 30-kDa antigen of Mycobacterium tuberculosis.	Reactive Oxygen Species	9-32	C-X-C motif chemokine ligand 8	Homo sapiens	36-41
20131678-6	2009	RESULTS: Fluoride uptake by incipient erosive lesions treated with toothpastes containing NaF was quantitatively compared by DSIMS and found to be directly proportional to the fluoride concentration over the studied range (0-1400 ppm).	Fluorides	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
18690522-3	2009	MATERIALS AND METHODS: In this study, we investigated the role of ROS in the activation of mitogen-activated protein kinases (MAPKs) and secretion of the CXC chemokine ligand 8 (CXCL8) and CC chemokine ligand 2 (CCL2) by human monocytes stimulated with the 30-kDa Ag of M. tuberculosis H37Rv.	Reactive Oxygen Species	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	154-176
20131678-6	2009	RESULTS: Fluoride uptake by incipient erosive lesions treated with toothpastes containing NaF was quantitatively compared by DSIMS and found to be directly proportional to the fluoride concentration over the studied range (0-1400 ppm).	Fluorides	176-184	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
18690522-3	2009	MATERIALS AND METHODS: In this study, we investigated the role of ROS in the activation of mitogen-activated protein kinases (MAPKs) and secretion of the CXC chemokine ligand 8 (CXCL8) and CC chemokine ligand 2 (CCL2) by human monocytes stimulated with the 30-kDa Ag of M. tuberculosis H37Rv.	Reactive Oxygen Species	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	178-183
19503841-0	2009	Persistently elevated level of IL-8 in Chlamydia trachomatis infected HeLa 229 cells is dependent on intracellular available iron.	Iron	125-129	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
18690522-5	2009	In addition, the 30-kDa Ag activated mRNA and protein expression of CXCL8 and CCL2 in human primary monocytes through nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent ROS generation.	NADP	118-161	C-X-C motif chemokine ligand 8	Homo sapiens	68-73
18690522-5	2009	In addition, the 30-kDa Ag activated mRNA and protein expression of CXCL8 and CCL2 in human primary monocytes through nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent ROS generation.	Reactive Oxygen Species	188-191	C-X-C motif chemokine ligand 8	Homo sapiens	68-73
18690522-10	2009	CONCLUSION: These results indicate that TLR2-ROS signaling plays a crucial role in the 30-kDa Ag-mediated expression of CXCL8 and CCL2 in human monocytes.	Reactive Oxygen Species	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	120-125
19109168-3	2009	Whether sex steroids affect IL-8 secretion of normal breast tissue or breast cancer is not known.	Steroids	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
19109168-9	2009	In experimental breast cancer, estradiol increased IL-8 whereas the anti-estrogen tamoxifen inhibited the secretion of IL-8 both in vitro and extracellularly in vivo in tumors of nude mice.	Estradiol	31-40	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
19109168-9	2009	In experimental breast cancer, estradiol increased IL-8 whereas the anti-estrogen tamoxifen inhibited the secretion of IL-8 both in vitro and extracellularly in vivo in tumors of nude mice.	Tamoxifen	82-91	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
19926933-0	2009	Suppressive effect of an isoflavone fraction on tumor necrosis factor-alpha-induced interleukin-8 production in human intestinal epithelial Caco-2 cells.	Isoflavones	25-35	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
19926933-2	2009	Among the soybean components, an isoflavone fraction (IFF) suppressed the TNF-alpha-induced IL-8 secretion by Caco-2 cells in a dose-dependent manner, whereas a soyasaponin fraction and soypeptide fraction had no significant effect on TNF-alpha-induced IL-8 secretion.	Isoflavones	33-43	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
19926933-3	2009	The IL-8 secretion induced by hydrogen peroxide and by IL-1beta was not suppressed by IFF, suggesting that the inhibitory effect of isoflavone was specific for the TNF-alpha-induced regulation of IL-8.	Hydrogen Peroxide	30-47	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
19926933-3	2009	The IL-8 secretion induced by hydrogen peroxide and by IL-1beta was not suppressed by IFF, suggesting that the inhibitory effect of isoflavone was specific for the TNF-alpha-induced regulation of IL-8.	Isoflavones	132-142	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
20150959-4	2009	In the present study, the concentrations of IL-8 in culture supernatants of HeLa cells treated with ROS were determined by enzyme-linked immunosorbent assay.	ros	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
20150959-7	2009	Enzyme-linked immunosorbent assays showed that IL-8 protein secretion was elevated in ROS-treated HeLa cells.	ros	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
20150959-8	2009	When Fe(2+) was removed from these cells, IL-8 secretion was inhibited.	ammonium ferrous sulfate	5-11	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
23230472-3	2009	The aim of this investigation was to evaluate fluoride uptake level of a locally prepared NaF rinse used in Iran"s school program during 2005.	Fluorides	46-54	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
19503841-3	2009	We examined the effect of iron chelators on IL-8 production in HeLa 229 (cervix epitheloid cell, CCL2) cells infected with C. trachomatis.	Iron	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
20150959-9	2009	Collectively, these results indicate that Fe(2+)-mediated Erk pathway activation is an important signal transduction pathway in ROS-induced IL-8 secretion in epithelial cells.	ammonium ferrous sulfate	42-48	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
20150959-9	2009	Collectively, these results indicate that Fe(2+)-mediated Erk pathway activation is an important signal transduction pathway in ROS-induced IL-8 secretion in epithelial cells.	ros	128-131	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
19503841-4	2009	IL-8 production was induced by Iron chelator DFO and Mimosine, however, synergy with chlamydial infection was obtained with DFO only.	Iron	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19503841-4	2009	IL-8 production was induced by Iron chelator DFO and Mimosine, however, synergy with chlamydial infection was obtained with DFO only.	Deferoxamine	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19503841-4	2009	IL-8 production was induced by Iron chelator DFO and Mimosine, however, synergy with chlamydial infection was obtained with DFO only.	Mimosine	53-61	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19503841-4	2009	IL-8 production was induced by Iron chelator DFO and Mimosine, however, synergy with chlamydial infection was obtained with DFO only.	Deferoxamine	124-127	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19503841-7	2009	These results indicate towards involvement of iron in chlamydia induced IL-8 production.	Iron	46-50	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
19247502-8	2009	At baseline, CD significantly (p&lt;0.05) induced IL-8 and NFkappaB reporter activities as compared to control cells suggesting a negative regulation of NFkappaB mediated IL-8 signaling by CFTR in cholesterol-rich lipid rafts.	methyl-beta-cyclodextrin	13-15	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
18830568-4	2009	We first observed that the spontaneous release of suPAR by resting neutrophils was strongly and rapidly (within minutes) enhanced by calcium ionophore ionomycin and to a lesser extent when cells were primed with TNF-alpha and then stimulated with fMLP or IL-8.	supar	50-55	C-X-C motif chemokine ligand 8	Homo sapiens	255-259
19246943-2	2009	In this study, we examined the effect of N-methyl-D-aspartate (NMDA) and sigma1-receptor ligands on the secretion of the proinflammatory chemokine interleukin 8 (IL-8) and the anti-inflammatory cytokine interleukin 10 (IL-10) in human leukemia Jurkat cells and peripheral blood lymphocytes (PBLs).	N-Methylaspartate	41-61	C-X-C motif chemokine ligand 8	Homo sapiens	147-160
19246943-2	2009	In this study, we examined the effect of N-methyl-D-aspartate (NMDA) and sigma1-receptor ligands on the secretion of the proinflammatory chemokine interleukin 8 (IL-8) and the anti-inflammatory cytokine interleukin 10 (IL-10) in human leukemia Jurkat cells and peripheral blood lymphocytes (PBLs).	N-Methylaspartate	41-61	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
19246943-2	2009	In this study, we examined the effect of N-methyl-D-aspartate (NMDA) and sigma1-receptor ligands on the secretion of the proinflammatory chemokine interleukin 8 (IL-8) and the anti-inflammatory cytokine interleukin 10 (IL-10) in human leukemia Jurkat cells and peripheral blood lymphocytes (PBLs).	N-Methylaspartate	63-67	C-X-C motif chemokine ligand 8	Homo sapiens	147-160
19246943-2	2009	In this study, we examined the effect of N-methyl-D-aspartate (NMDA) and sigma1-receptor ligands on the secretion of the proinflammatory chemokine interleukin 8 (IL-8) and the anti-inflammatory cytokine interleukin 10 (IL-10) in human leukemia Jurkat cells and peripheral blood lymphocytes (PBLs).	N-Methylaspartate	63-67	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
19246943-3	2009	We have shown that NMDA increased IL-8 and decreased IL-10 secretion and that sigma-ligands modulated the action of NMDA.	N-Methylaspartate	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
19247502-8	2009	At baseline, CD significantly (p&lt;0.05) induced IL-8 and NFkappaB reporter activities as compared to control cells suggesting a negative regulation of NFkappaB mediated IL-8 signaling by CFTR in cholesterol-rich lipid rafts.	methyl-beta-cyclodextrin	13-15	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
19247502-8	2009	At baseline, CD significantly (p&lt;0.05) induced IL-8 and NFkappaB reporter activities as compared to control cells suggesting a negative regulation of NFkappaB mediated IL-8 signaling by CFTR in cholesterol-rich lipid rafts.	Cholesterol	197-208	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
19365107-10	2009	Upon tumor necrosis factor-alpha stimulation, IL-6 and IL-8 mRNA and protein levels in A549-PLA2G2D-Ser cells were elevated compared with those of A549-PLA2G2D-Gly cells.	Serine	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
19365107-9	2009	A549-PLA2G2D-Ser cells spontaneously produced higher levels of interleukin (IL)-6 and IL-8 than A549-PLA2G2D-Gly cells.	Serine	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
19365107-11	2009	Upon hydrogen peroxide stimulation, IL-8 mRNA and protein levels in A549-PLA2G2D-Ser cells were higher than those of A549-PLA2G2D-Gly cells.	Hydrogen Peroxide	5-22	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
19365107-11	2009	Upon hydrogen peroxide stimulation, IL-8 mRNA and protein levels in A549-PLA2G2D-Ser cells were higher than those of A549-PLA2G2D-Gly cells.	Serine	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
19365107-12	2009	CONCLUSIONS: PLA2G2D-Ser enhances the expression of IL-6 and IL-8 compared with PLA2G2D-Gly.	Serine	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
18951912-10	2009	Acrolein treatment led to activation and nuclear translocation of the transcription factor NF-kappaB and an increase in TNF-alpha, IL-6 and IL-8, but not MCP-1, mRNA.	Acrolein	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
19139781-5	2009	RESULTS: Silymarin reduces significantly serum levels of IL-1 alpha and IL-8, C3 and C4 after 8 weeks compared to the pre-treatment levels.	Silymarin	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
19139781-9	2009	Adjunct use of silymarin with piroxicam results in significant reduction in both cytokines (IL-1 alpha and IL-8), and serum levels of C3 and C4.	Silymarin	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
19139781-9	2009	Adjunct use of silymarin with piroxicam results in significant reduction in both cytokines (IL-1 alpha and IL-8), and serum levels of C3 and C4.	Piroxicam	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
19247848-7	2009	In ATV-stimulated FLS a significant downregulation of proinflammatory cytokine (IL-6) and chemokine (IL-8) expression was detected (p&lt;0.001).	Atorvastatin	3-6	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
19050703-2	2008	In vitro experiments conducted on PC3 and human bone marrow endothelial cells (hBMECs) determined that administration of DEX (10 nM) reduced constitutive nuclear factor-kappaB (NF-kappaB) activity, decreasing interleukin (IL)-8, CXCL1 and VEGF gene expression in PC3 cells.	Dexamethasone	121-124	C-X-C motif chemokine ligand 8	Homo sapiens	209-227
18824136-7	2009	Moreover, both promoter activity and release of IL-8 were inhibited by U0126 and curcumin, but not by SB202190, epigallocatechin 3-gallate and resveratrol.	U 0126	71-76	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
18824136-7	2009	Moreover, both promoter activity and release of IL-8 were inhibited by U0126 and curcumin, but not by SB202190, epigallocatechin 3-gallate and resveratrol.	Curcumin	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
19050703-3	2008	Dexamethasone also attenuated docetaxel-induced NF-kappaB and activator protein-1 transcription and reduced docetaxel-promoted expression/secretion of IL-8 and CXCL1 in PC3 and hBMECs.	Docetaxel	108-117	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
19542657-4	2009	The iron nanotubes were fabricated in 1 M Na(2)SO(4) + 0.5 wt% NaF electrolyte by supplying constant electric currents of 50 mV/s, and holding the potential at 20, 40 and 60 V for 20 min.	Iron	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
18840498-6	2008	Ethanol decreased LPS-stimulated IL-6, IL-8, TNF-alpha, and MCP-1 dose-dependently (all p&lt;0.01).	Ethanol	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
19050703-3	2008	Dexamethasone also attenuated docetaxel-induced NF-kappaB and activator protein-1 transcription and reduced docetaxel-promoted expression/secretion of IL-8 and CXCL1 in PC3 and hBMECs.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
19012411-11	2008	Toxic shock syndrome toxin-1 residue D130 may contribute to binding an epithelial receptor, which allows it to penetrate the vaginal mucosa, induce interleukin-8, and cause toxic shock syndrome.	d130	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	148-161
18854173-4	2008	The PAR2-triggered IL-8 release was suppressed by inhibitors of MEK (U0126) or PI3-kinase (LY294002), and PAR2 stimulation indeed activated the downstream kinases, ERK and Akt.	U 0126	69-74	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
18854173-4	2008	The PAR2-triggered IL-8 release was suppressed by inhibitors of MEK (U0126) or PI3-kinase (LY294002), and PAR2 stimulation indeed activated the downstream kinases, ERK and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
19074906-8	2008	Furthermore, rapamycin not only drastically inhibited CXCL16-induced PCa cell invasion and growth but reduced secretion of IL-8 or VEGF levels and inhibited expression of other CXCR6 targets including CD44 and matrix metalloproteinase 3 in PCa cells.	Sirolimus	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
19367948-1	2008	A novel method has been developed to prepare vesicles from aqueous solutions of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, by adding anionic surfactant sodium dodecyl sulfate (SDS) and inorganic salt NaF.	poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer	80-162	C-X-C motif chemokine ligand 8	Homo sapiens	241-244
19032233-8	2008	TNF-alpha-induced GRO-alpha and IL-8 were slightly attenuated by DEX treatment (reaches to 89% and 79%, respectively), whereas expressions of IP-10, ICAM-1 and VCAM-1 were significantly enhanced by the same treatment (up to 172%, 152% and 139%, respectively).	Dexamethasone	65-68	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
18838587-8	2008	Colposcopy and biopsy studies indicate that GML does not alter normal mucosal integrity and does not induce inflammation; instead, GML reduces epithelial cell production of interleukin 8.	monolaurin	131-134	C-X-C motif chemokine ligand 8	Homo sapiens	173-186
18665800-0	2008	15d-PGJ2 upregulates synthesis of IL-8 in endothelial cells through induction of oxidative stress.	15-deoxyprostaglandin J2	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
19064561-10	2008	Only IL4, IL6, and IL8 had statistically significant correlations (Spearman rho, 0.42-0.94) between serum and acid citrate dextrose or heparin plasma levels.	acid citrate dextrose	110-131	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
18665800-2	2008	It has been demonstrated that 15d-PGJ(2) potently increases the generation of interleukin-8 (IL-8) in human microvascular endothelial cells (HMEC-1s); however, the mechanism of this induction is not known.	15d-pgj	30-37	C-X-C motif chemokine ligand 8	Homo sapiens	78-91
18665800-2	2008	It has been demonstrated that 15d-PGJ(2) potently increases the generation of interleukin-8 (IL-8) in human microvascular endothelial cells (HMEC-1s); however, the mechanism of this induction is not known.	15d-pgj	30-37	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
18665800-3	2008	The aim of the study was to find the pathway involved in 15d-PGJ(2)-mediated IL-8 stimulation.	2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE	61-64	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
19064561-10	2008	Only IL4, IL6, and IL8 had statistically significant correlations (Spearman rho, 0.42-0.94) between serum and acid citrate dextrose or heparin plasma levels.	Heparin	135-142	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
19036603-7	2008	The mean percentage of the inhibition of IL-6, CXCL8/IL-8, CCL3/MIP-1alpha by bestatin at a concentration of 50 microg/mL was 71.2%, 29.7% and 61.0%, respectively.	ubenimex	78-86	C-X-C motif chemokine ligand 8	Homo sapiens	47-52
19033802-3	2008	For a comprehensive morphologic and scintigraphic evaluation, a whole-body F-18 sodium fluoride (NaF) PET-CT was acquired.	Sodium Fluoride	80-95	C-X-C motif chemokine ligand 8	Homo sapiens	97-100
19036603-7	2008	The mean percentage of the inhibition of IL-6, CXCL8/IL-8, CCL3/MIP-1alpha by bestatin at a concentration of 50 microg/mL was 71.2%, 29.7% and 61.0%, respectively.	ubenimex	78-86	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
19036603-9	2008	The treatment with bestatin significantly inhibited the production of IL-6 and CXCL8/IL-8 by AM from patients with sarcoidosis.	ubenimex	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
19036603-9	2008	The treatment with bestatin significantly inhibited the production of IL-6 and CXCL8/IL-8 by AM from patients with sarcoidosis.	ubenimex	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	79-84
19186852-11	2008	The change of Area, deltaF and lg deltaQ of the lesions in NaF group and MFP group exhibited significant decreases than that of no-fluoride dentifrice group (P&lt;0.05).	Fluorides	131-139	C-X-C motif chemokine ligand 8	Homo sapiens	59-62
19103522-6	2008	From a mechanistic point of view, by blocking independently Galphai protein or intracellular calcium, monocytes lose the ability to secrete CXCL8 in response to PROK1.	Calcium	93-100	C-X-C motif chemokine ligand 8	Homo sapiens	140-145
19103523-9	2008	After treatment with 10 microM of gossypol, there was a 1.5-fold decrease in angiogenin and IL-8 levels and a 1.7- and 1.8-fold decrease in ENA-78 and GRO-alpha levels respectively, in DU-145 cells.	Gossypol	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
18809662-10	2008	FlaA-induced IL-8 production in T84 cells was inhibited by the p38 inhibitor in combination with either the JNK or ERK inhibitors.	flaa	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
18780829-3	2008	This study sought to determine the significance of CXCL8 signaling in regulating the response of AIPC cells to oxaliplatin, a drug whose activity is reportedly sensitive to NF-kappaB activity.	Oxaliplatin	111-122	C-X-C motif chemokine ligand 8	Homo sapiens	51-56
19022976-7	2008	Arg(high)/Gln(high) decreased the production of TNFalpha, IL-1beta, IL-8, and IL-6 (each P &lt; 0.01).	Arginine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
19022976-7	2008	Arg(high)/Gln(high) decreased the production of TNFalpha, IL-1beta, IL-8, and IL-6 (each P &lt; 0.01).	Glutamine	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
19022976-8	2008	Arg(low)/Gln(high) decreased IL-6 and IL-8 production (both P &lt; 0.01), whereas Arg(high)/Gln(low) did not affect cytokine and NO production.	Arginine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
19022976-8	2008	Arg(low)/Gln(high) decreased IL-6 and IL-8 production (both P &lt; 0.01), whereas Arg(high)/Gln(low) did not affect cytokine and NO production.	Glutamine	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
18780829-5	2008	In addition, oxaliplatin increased the transcription and secretion of CXCL8 and the related CXC-chemokine CXCL1 and increased the transcription and expression of CXC-chemokine receptors, especially CXC-chemokine receptor (CXCR) 2, which transduces the biological effects of CXCL8 and CXCL1.	Oxaliplatin	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	70-75
18780829-5	2008	In addition, oxaliplatin increased the transcription and secretion of CXCL8 and the related CXC-chemokine CXCL1 and increased the transcription and expression of CXC-chemokine receptors, especially CXC-chemokine receptor (CXCR) 2, which transduces the biological effects of CXCL8 and CXCL1.	Oxaliplatin	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	274-279
19055699-7	2008	CBA confirmed upregulation of IL-8 and show upregulation of IL-1beta in the tumours (P &lt; 0.05).	cba	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
18688800-5	2008	High glucose-induced MCP-1 and IL-8 mRNA expression levels also decreased by ABO.	Glucose	5-12	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
19046427-7	2008	The cell response to IL-8 was determined by measuring intracellular calcium concentration ([Ca2+](i)), cell contraction, migration and proliferation.	Calcium	68-75	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
18789311-2	2008	In the present study, we demonstrated that reorganization of actin cytoskeleton induced by Cytochalasin D (CytD), an actin-polymerization inhibitor, enhanced il-8 gene expression induced by TNFalpha and LPS in HL-60 monocyte-like cells.	Cytochalasin D	91-105	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
19132242-2	2008	Since nuclear factor-kappaB (NF-kappaB) is a major regulator of IL-8 transcription, we studied its activation in endothelial cells treated with E-LDL.	e-ldl	144-149	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
18535203-6	2008	PMN chemotactic responses to formylmethionyl-leucyl-phenylalanine (fMLP) and IL-8 were dose-dependently inhibited by treatment with the PPAR-gamma ligands troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) and by transfection of PMN-like HL-60 cells with a constitutively active PPAR-gamma construct.	Troglitazone	155-167	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
18535203-6	2008	PMN chemotactic responses to formylmethionyl-leucyl-phenylalanine (fMLP) and IL-8 were dose-dependently inhibited by treatment with the PPAR-gamma ligands troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) and by transfection of PMN-like HL-60 cells with a constitutively active PPAR-gamma construct.	15-deoxy-delta	172-186	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
18535203-6	2008	PMN chemotactic responses to formylmethionyl-leucyl-phenylalanine (fMLP) and IL-8 were dose-dependently inhibited by treatment with the PPAR-gamma ligands troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) and by transfection of PMN-like HL-60 cells with a constitutively active PPAR-gamma construct.	prostaglandin j	194-209	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
18981129-9	2008	In contrast to induction of the antimicrobial peptide, vitamin D attenuates dsRNA-induced expression of the NF-kappaB-driven gene IL-8.	Vitamin D	55-64	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
18535203-6	2008	PMN chemotactic responses to formylmethionyl-leucyl-phenylalanine (fMLP) and IL-8 were dose-dependently inhibited by treatment with the PPAR-gamma ligands troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) and by transfection of PMN-like HL-60 cells with a constitutively active PPAR-gamma construct.	2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE	218-221	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
18698005-3	2008	In the presence of exogenous PGE(2), peripheral blood mononuclear cells produced higher interleukin-17 (IL-17), C-C chemokine ligand 20 (CCL20)/macrophage inflammatory protein 3alpha (MIP-3alpha), CXC chemokine ligand 8 (CXCL8)/IL-8, and lower interferon-gamma and IL-22 levels than in control cultures.	Prostaglandins E	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	197-219
19014534-0	2008	IL-1beta differently involved in IL-8 and FGF-2 release in crystalline silica-treated lung cell co-cultures.	Silicon Dioxide	71-77	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
19014534-2	2008	The aim of the present study was to investigate the effect of crystalline silica on the release of the fibrosis- and angiogenesis-related mediator FGF-2 and the pro-inflammatory mediator IL-8, and how IL-1beta and TNF-alpha were involved in this release from various mono- and co-cultures of monocytes, pneumocytes and endothelial cells.	Silicon Dioxide	74-80	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
19014534-3	2008	RESULTS: Silica exposure induced an increase of IL-8 release from monocytes and from pneumocytes alone, and the FGF-2 level in the medium increased upon silica exposure of pneumocytes.	Silicon Dioxide	9-15	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
19014534-10	2008	CONCLUSION: IL-1beta seems to be differently involved in the silica-induced release of IL-8 and FGF-2 in different lung cell cultures.	Silicon Dioxide	61-67	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
19014534-11	2008	Whereas the silica-induced IL-8 release is regulated via an IL-1-receptor-mediated mechanism, IL-1beta is suggested only indirectly to affect the silica-induced FGF-2 release by counteracting pneumocyte loss.	Silicon Dioxide	12-18	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
18976019-9	2008	Interleukin 6 concentrations were stable for 8 hours in all blood types, whereas interleukin 8 concentrations were stable only in EDTA plasma and were strongly increasing in heparin plasma and serum.	Edetic Acid	130-134	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
18976019-9	2008	Interleukin 6 concentrations were stable for 8 hours in all blood types, whereas interleukin 8 concentrations were stable only in EDTA plasma and were strongly increasing in heparin plasma and serum.	Heparin	174-181	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
18474668-7	2008	Exposure to gamma-iE-DAP at the apical surface of differentiated, polarized cultures resulted in activation of the innate immune response in an NOD1- and RIP2-dependent manner, resulting in release of IL-6 and IL-8.	N(2)-(gamma-D-glutamyl)-meso-2,2'-diaminopimelic acid	12-24	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
18996285-7	2008	RESULTS: NF-kappaB p65 antisense oligonucleotides resulted in downregulation of NF-kappaB p65 expression, blocked the expression of IL-1beta mRNA and IL-8 mRNA, and strikingly reduced the production of IL-1beta and IL-8.	Oligonucleotides	33-49	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
18996285-7	2008	RESULTS: NF-kappaB p65 antisense oligonucleotides resulted in downregulation of NF-kappaB p65 expression, blocked the expression of IL-1beta mRNA and IL-8 mRNA, and strikingly reduced the production of IL-1beta and IL-8.	Oligonucleotides	33-49	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
18975306-10	2008	ACh significantly reduced the production of IL-6, CXCL8, CCL2, CCL3, CCL5, and granulocyte colony-stimulating factor by IL-1-stimulated FLS.	Acetylcholine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	50-55
18698005-3	2008	In the presence of exogenous PGE(2), peripheral blood mononuclear cells produced higher interleukin-17 (IL-17), C-C chemokine ligand 20 (CCL20)/macrophage inflammatory protein 3alpha (MIP-3alpha), CXC chemokine ligand 8 (CXCL8)/IL-8, and lower interferon-gamma and IL-22 levels than in control cultures.	Prostaglandins E	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	221-226
18698005-3	2008	In the presence of exogenous PGE(2), peripheral blood mononuclear cells produced higher interleukin-17 (IL-17), C-C chemokine ligand 20 (CCL20)/macrophage inflammatory protein 3alpha (MIP-3alpha), CXC chemokine ligand 8 (CXCL8)/IL-8, and lower interferon-gamma and IL-22 levels than in control cultures.	Prostaglandins E	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	228-232
18617617-0	2008	Lysophosphatidic acid mediates interleukin-8 expression in human endometrial stromal cells through its receptor and nuclear factor-kappaB-dependent pathway: a possible role in angiogenesis of endometrium and placenta.	lysophosphatidic acid	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	31-44
19085374-7	2008	Besifloxacin significantly inhibited IL-1beta-induced cytokine release in a dose-dependent manner, with a comparable (IL-8) or better (G-CSF, GM-CSF, IL-6, MCP-1, MIP-1beta, TGF-alpha, and TNF-alpha) efficacy compared to moxifloxacin.	besifloxacin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
18617617-11	2008	LPA enhanced IL-8 expression in a dose- and time-dependent manner, whereas vascular endothelial growth factor or IL-6 expression was not affected by LPA treatment.	lysophosphatidic acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
18617617-15	2008	Through the LPA1 receptor, LPA induces IL-8 expression via a nuclear factor-kappaB-dependent signal pathway.	lysophosphatidic acid	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
18697197-4	2008	Treatment of tumor cells with doxorubicin and cisplatin resulted in a substantial increase in the production of IL-6, CXCL8, CCL2, CCL5, BFGF, G-CSF and VEGF.	Doxorubicin	30-41	C-X-C motif chemokine ligand 8	Homo sapiens	118-123
19075349-5	2008	We have found that in peripheral blood lymphocytes glutamate at the concentrations within normal plasma levels (1 x 10(-5) M), as well as at lower concentration (0.3 x 10(-6) M) changes the secretion of immunosuppressive cytokine IL-10, whereas synthesis of proinflammatory chemokine, IL-8 did not changed significantly.	Glutamic Acid	51-60	C-X-C motif chemokine ligand 8	Homo sapiens	285-289
18653652-7	2008	Tricultures with EAHY926 released more G-CSF, MIP-1alpha, IL-8 and MIP-1beta than the EAHY926 single culture.	eahy926	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
19001436-7	2008	These results suggest that tanshinone I exhibits anticancer effects both in vitro and in vivo and that these effects are mediated at least partly through the interleukin-8, Ras-mitogen-activated protein kinase, and Rac1 signaling pathways.	tanshinone	27-39	C-X-C motif chemokine ligand 8	Homo sapiens	158-171
19109744-7	2008	Significant inhibition (P &gt; 0.05) of TNF-alpha, IL-6 and IL-8 at non-toxic of digoxin concentration (&lt; 100 nM) and DLIF (10 nM digoxin equivalent (de)) was observed whereas no such effect was seen for IL-10.	Digoxin	81-88	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
19109744-7	2008	Significant inhibition (P &gt; 0.05) of TNF-alpha, IL-6 and IL-8 at non-toxic of digoxin concentration (&lt; 100 nM) and DLIF (10 nM digoxin equivalent (de)) was observed whereas no such effect was seen for IL-10.	Digoxin	133-140	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
18971093-9	2008	Azithromycin caused a significant decrease in the LPS-stimulated IL-8 and GM-CSF release.	Azithromycin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
18728240-0	2008	Clotrimazole ameliorates intestinal inflammation and abnormal angiogenesis by inhibiting interleukin-8 expression through a nuclear factor-kappaB-dependent manner.	Clotrimazole	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	89-102
18728240-2	2008	In the present study, we investigated the fact that clotrimazole (CLT) inhibits intestinal inflammation, and the inhibitory action is mediated through suppression of IL-8 expression.	Clotrimazole	52-64	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
18728240-2	2008	In the present study, we investigated the fact that clotrimazole (CLT) inhibits intestinal inflammation, and the inhibitory action is mediated through suppression of IL-8 expression.	Clotrimazole	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
18728240-6	2008	Furthermore, cotreatment with CLT and pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, synergistically reduced the NF-kappaB transcriptional activity as well as IL-8 expression.	Clotrimazole	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
18728240-6	2008	Furthermore, cotreatment with CLT and pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, synergistically reduced the NF-kappaB transcriptional activity as well as IL-8 expression.	pyrrolidine dithiocarbamic acid	38-65	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
18779317-9	2008	Consequently, induction of interleukin-8 and beta interferon after poly(I-C) stimulation was impaired in HCT116 p53(-/-) cells.	Poly I-C	67-76	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
18697197-4	2008	Treatment of tumor cells with doxorubicin and cisplatin resulted in a substantial increase in the production of IL-6, CXCL8, CCL2, CCL5, BFGF, G-CSF and VEGF.	Cisplatin	46-55	C-X-C motif chemokine ligand 8	Homo sapiens	118-123
18541460-9	2008	While neutrophil cell counts and IL-8 levels decreased, the LXA(4) levels significantly increased after antibiotics therapy and were inversely correlated with IL-8 levels.	lxa(	60-64	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
18941244-8	2008	The p38 and ERK pathway inhibitors SB203580 and U0126 reversed the repressive effect of IL-17 on CXCL10 mRNA abundance and promoter activity and also reversed the inductive effect of IL-17 on CXCL8 mRNA, indicating that MAPK signaling mediates both the transcriptional repression of CXCL10 and the stabilization of CXCL8 mRNA by IL-17.	SB 203580	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	192-197
18941244-8	2008	The p38 and ERK pathway inhibitors SB203580 and U0126 reversed the repressive effect of IL-17 on CXCL10 mRNA abundance and promoter activity and also reversed the inductive effect of IL-17 on CXCL8 mRNA, indicating that MAPK signaling mediates both the transcriptional repression of CXCL10 and the stabilization of CXCL8 mRNA by IL-17.	SB 203580	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	315-320
18941244-8	2008	The p38 and ERK pathway inhibitors SB203580 and U0126 reversed the repressive effect of IL-17 on CXCL10 mRNA abundance and promoter activity and also reversed the inductive effect of IL-17 on CXCL8 mRNA, indicating that MAPK signaling mediates both the transcriptional repression of CXCL10 and the stabilization of CXCL8 mRNA by IL-17.	U 0126	48-53	C-X-C motif chemokine ligand 8	Homo sapiens	192-197
18941244-8	2008	The p38 and ERK pathway inhibitors SB203580 and U0126 reversed the repressive effect of IL-17 on CXCL10 mRNA abundance and promoter activity and also reversed the inductive effect of IL-17 on CXCL8 mRNA, indicating that MAPK signaling mediates both the transcriptional repression of CXCL10 and the stabilization of CXCL8 mRNA by IL-17.	U 0126	48-53	C-X-C motif chemokine ligand 8	Homo sapiens	315-320
18941244-9	2008	The EGFR kinase inhibitor AG1478 partially reversed the effects of IL-17 on CXCL8 and CXCL10 mRNA, demonstrating a role for EGFR in downstream IL-17 signaling.	RTKI cpd	26-32	C-X-C motif chemokine ligand 8	Homo sapiens	76-81
18587146-3	2008	Stepwise multiple regression analyses of factors including age, occupation, years of employment, alcohol drinking behaviour, physical activity, nutritional balance and cigarette smoking parameters showed that LECT was a positively significant predictor (Partial r = 0.0005, P &lt; 0.05) of the comet tail moment.	Alcohols	97-104	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
18587146-4	2008	In consideration of the high correlation between LECT and LECN (Y(tar) = 12.53 X(nicotine) -7.23, r = 0.995, P &lt; 0.0001), these results suggest that levels of exposure to cigarette tar or nicotine (mg/day) would be a sensitive parameter in appreciation of genotoxicity of cigarette smoking in these male Japanese smokers.	Nicotine	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
18764914-4	2008	RESULTS: All mediators were detectable in serum and all but IL-8 were detectable in EBC.	NSC638702	84-87	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
18669446-3	2008	Treatment of MCF-7 cells with the HDAC inhibitor trichostatin A (TSA) led to a strong up-regulation of IL-8 protein and RNA levels in MCF-7 cells.	trichostatin A	49-63	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
18669446-3	2008	Treatment of MCF-7 cells with the HDAC inhibitor trichostatin A (TSA) led to a strong up-regulation of IL-8 protein and RNA levels in MCF-7 cells.	trichostatin A	65-68	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
18669446-9	2008	TSA increased binding of acetylated histone 3 to the IL-8 gene promoter.	trichostatin A	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
18701168-4	2008	It also enhanced neutrophil IL-8 production induced by double-stranded bacterial DNA, methylated single-stranded DNA, plasmid DNA, and phosphorothioated-CpG and non-CpG-oligodeoxynucleotides.	phosphorothioated-cpg	135-156	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
19084961-8	2008	Both Pg-LPS and E-LPS induced IL-8 secretion by THP-1 cells (P&lt;0.01), but only Pg-LPS showed the similar effect on HGF-1 cells (P&lt;0.01).	pg-lps	5-11	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
18277946-4	2008	Both PAR2-AP and the endogenous PAR2 activator trypsin caused concentration- and time-dependent increase in endothelial IL-8 production, and this effect was concentration dependently and selectively attenuated by the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580.	SB 203580	271-279	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
19010201-0	2008	Analysis of interleukin-6 and interleukin-8 in lung transplantation: correlation with nitric oxide administration.	Nitric Oxide	86-98	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
19084961-8	2008	Both Pg-LPS and E-LPS induced IL-8 secretion by THP-1 cells (P&lt;0.01), but only Pg-LPS showed the similar effect on HGF-1 cells (P&lt;0.01).	e-lps	16-21	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
18675368-9	2008	So echinomycin-induced apoptosis in HT-29 cells occurs via NF-kappaB activation independent of caspase-3 activation modulating the resultant-linked key chemokine IL-8 expression and echinomycin-induced apoptosis is NF-kappaB-dependant and directly related to NF-kappaB activation, consequently regulating IL-8 expression.	Echinomycin	3-14	C-X-C motif chemokine ligand 8	Homo sapiens	305-309
18772138-0	2008	Regulation of interleukin-8 gene at a distinct site of its promoter by CCAAT enhancer-binding protein homologous protein in prostaglandin E2-treated human T cells.	Dinoprostone	124-140	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
18772138-2	2008	We have previously shown that in human T lymphocytes the CHOP phosphorylation induced by prostaglandin E(2) (PGE(2))-increased interleukin-8 (IL-8) gene expression.	Dinoprostone	89-107	C-X-C motif chemokine ligand 8	Homo sapiens	127-140
18772138-2	2008	We have previously shown that in human T lymphocytes the CHOP phosphorylation induced by prostaglandin E(2) (PGE(2))-increased interleukin-8 (IL-8) gene expression.	Dinoprostone	89-107	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
18772138-2	2008	We have previously shown that in human T lymphocytes the CHOP phosphorylation induced by prostaglandin E(2) (PGE(2))-increased interleukin-8 (IL-8) gene expression.	Prostaglandins E	109-112	C-X-C motif chemokine ligand 8	Homo sapiens	127-140
18772138-2	2008	We have previously shown that in human T lymphocytes the CHOP phosphorylation induced by prostaglandin E(2) (PGE(2))-increased interleukin-8 (IL-8) gene expression.	Prostaglandins E	109-112	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
18772138-3	2008	Given the CHOP positive role in the regulation of transcription, here we have investigated the molecular mechanism(s) by which CHOP increases IL-8 gene activity under PGE(2) stimulus.	Prostaglandins E	167-170	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
18772138-5	2008	CHOP silencing confirmed its role in the IL-8 transcriptional regulation and protein production, whereas c-Jun small interfering RNA experiments showed that the PGE(2)-induced activation of IL-8 promoter is mainly c-Jun-independent.	Prostaglandins E	161-164	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
18772138-6	2008	Moreover, PGE(2) induced CHOP-DNA complexes only when the entire IL-8/AP-1 promoter or the wild type sequences encompassing the AP-1 upstream region were employed.	Prostaglandins E	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
18772138-8	2008	The IL-8/AP-1 mutant promoter lacking the sequence immediately upstream the AP-1 site is PGE(2)-unresponsive.	Dinoprostone	89-95	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
18772138-9	2008	Finally, chromatin immunoprecipitation data confirmed in vivo that PGE(2) induces CHOP binding to the IL-8 promoter.	Dinoprostone	67-73	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
18772138-10	2008	Taken together, our results suggest that the increased expression of CHOP in response to PGE(2) exerts a positive transcriptional regulation of the IL-8 promoter mediated by direct binding to a novel consensus site.	Prostaglandins E	89-92	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
18713747-3	2008	Here we show that that ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1, CD39) is a critical enzyme for hydrolysis of released ATP by neutrophils and for cell migration in response to multiple agonists (N-formyl-methionyl-leucyl-phenylalanine, interleukin-8, and C5a).	Adenosine Triphosphate	140-143	C-X-C motif chemokine ligand 8	Homo sapiens	257-270
18692129-7	2008	The data indicate that activation of JNK1/AP-1 and subsequent IL-8 induction in hyperoxia are mediated by intracellular ROS, with SOD having significant protective effects.	Reactive Oxygen Species	120-123	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
18675368-9	2008	So echinomycin-induced apoptosis in HT-29 cells occurs via NF-kappaB activation independent of caspase-3 activation modulating the resultant-linked key chemokine IL-8 expression and echinomycin-induced apoptosis is NF-kappaB-dependant and directly related to NF-kappaB activation, consequently regulating IL-8 expression.	Echinomycin	3-14	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
18675302-6	2008	Moreover, NOS inhibitor (L-NAME) and anti-TLR 4mAb reduced the LPS-induced NO, IL-8 and VEGF production and ICAM-1 expression.	NG-Nitroarginine Methyl Ester	25-31	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
18837496-10	2008	The hydration number N h and the dielectric relaxation property of the hydration layer for each salt solution was successfully determined as ( f c1, delta 1, N h)= (18.7, 44.9, 27.9) for NaCl and ( f c1, delta 1, f c2, delta 2, N h) = (26.0, 6.70, 5.64, 19.2) for NaF.	Salts	96-100	C-X-C motif chemokine ligand 8	Homo sapiens	264-267
18837496-10	2008	The hydration number N h and the dielectric relaxation property of the hydration layer for each salt solution was successfully determined as ( f c1, delta 1, N h)= (18.7, 44.9, 27.9) for NaCl and ( f c1, delta 1, f c2, delta 2, N h) = (26.0, 6.70, 5.64, 19.2) for NaF.	Sodium Chloride	187-191	C-X-C motif chemokine ligand 8	Homo sapiens	264-267
18767879-2	2008	The experimental results indicate that addition of NaF, NaCl, NaHCO 3, or NaNO 3 can result in phase inversion of ATPS-C formed by 12-3-12/AS systems; however, addition of NaBr cannot lead to phase inversion.	atps-c	114-120	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
18767879-2	2008	The experimental results indicate that addition of NaF, NaCl, NaHCO 3, or NaNO 3 can result in phase inversion of ATPS-C formed by 12-3-12/AS systems; however, addition of NaBr cannot lead to phase inversion.	Arsenic	139-141	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
18767879-5	2008	Phase composition analysis results illustrate that for the ATPS-C formed by 0.10 mol.kg (-1) 12-3-12/AS mixed system, the concentration of Br (-) counterions in the dilute phase of ATPS-C increases with addition of NaF, NaCl, NaHCO 3, or NaNO 3.	atps-c	59-65	C-X-C motif chemokine ligand 8	Homo sapiens	215-218
18767879-5	2008	Phase composition analysis results illustrate that for the ATPS-C formed by 0.10 mol.kg (-1) 12-3-12/AS mixed system, the concentration of Br (-) counterions in the dilute phase of ATPS-C increases with addition of NaF, NaCl, NaHCO 3, or NaNO 3.	atps-c	181-187	C-X-C motif chemokine ligand 8	Homo sapiens	215-218
18767879-5	2008	Phase composition analysis results illustrate that for the ATPS-C formed by 0.10 mol.kg (-1) 12-3-12/AS mixed system, the concentration of Br (-) counterions in the dilute phase of ATPS-C increases with addition of NaF, NaCl, NaHCO 3, or NaNO 3.	Sodium Chloride	220-224	C-X-C motif chemokine ligand 8	Homo sapiens	215-218
18767879-5	2008	Phase composition analysis results illustrate that for the ATPS-C formed by 0.10 mol.kg (-1) 12-3-12/AS mixed system, the concentration of Br (-) counterions in the dilute phase of ATPS-C increases with addition of NaF, NaCl, NaHCO 3, or NaNO 3.	nahco	226-231	C-X-C motif chemokine ligand 8	Homo sapiens	215-218
18767879-9	2008	Density experiments illustrate that the density increase of the dilute phase is larger than that of the concentrated phase in the ATPS-C with addition of NaF, NaCl, NaHCO 3, or NaNO 3; thus, phase inversion occurs.	atps-c	130-136	C-X-C motif chemokine ligand 8	Homo sapiens	154-157
18675368-0	2008	NF-kappaB-dependency and consequent regulation of IL-8 in echinomycin-induced apoptosis of HT-29 colon cancer cells.	Echinomycin	58-69	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
18675368-6	2008	To clarify the role of NF-kappaB on IL-8 expression in echinomycin-mediated apoptosis of HT-29 cells, ELISA plus RT-PCR clearly showed that IL-8 production is inducible by echinomycin treatment.	Echinomycin	55-66	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
18675368-6	2008	To clarify the role of NF-kappaB on IL-8 expression in echinomycin-mediated apoptosis of HT-29 cells, ELISA plus RT-PCR clearly showed that IL-8 production is inducible by echinomycin treatment.	Echinomycin	55-66	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
18675368-6	2008	To clarify the role of NF-kappaB on IL-8 expression in echinomycin-mediated apoptosis of HT-29 cells, ELISA plus RT-PCR clearly showed that IL-8 production is inducible by echinomycin treatment.	Echinomycin	172-183	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
18675368-7	2008	Using a specific inhibitor, IL-8 regulation at echinomycin treatment in HT-29 cells occurred via both caspase-3 and NF-kappaB-dependent signal pathway.	Echinomycin	47-58	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
18789871-3	2008	Incubation of monocytes with insulin for 2h induced CXCL8 mRNA and secretion whereas glucose had no effect.	Deuterium	41-43	C-X-C motif chemokine ligand 8	Homo sapiens	52-57
19046206-1	2008	AIMS: To measure capillary permeability, assessed by skin capillary sodium fluorescein (NaF) leakage, in patients with diabetes mellitus with critical limb ischaemia (DM-CLI) and to compare the effects of vascular endothelial growth factor (VEGF) with those of placebo.	Fluorescein	68-86	C-X-C motif chemokine ligand 8	Homo sapiens	88-91
18789871-5	2008	In contrast, blockage of the ERK-specific MAP kinase MEK with PD98059, that prevents phosphorylation of ERK1/ERK2, abrogated insulin-induced CXCL8 release in primary monocytes.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	62-69	C-X-C motif chemokine ligand 8	Homo sapiens	141-146
18789871-1	2008	Oral glucose uptake alters the function of immune cells and an elevation of systemic CXCL8 was described.	Glucose	5-12	C-X-C motif chemokine ligand 8	Homo sapiens	85-90
18789871-2	2008	Monocytes secrete high amounts of CXCL8 and therefore it was analyzed whether glucose or insulin upregulate monocytic CXCL8 release.	Glucose	78-85	C-X-C motif chemokine ligand 8	Homo sapiens	118-123
18789871-7	2008	CXCL8 was also higher when determined in the cell lysate of leukocytes 2h after glucose uptake whereas plasma CXCL8 levels were significantly reduced.	Deuterium	71-73	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
18789871-7	2008	CXCL8 was also higher when determined in the cell lysate of leukocytes 2h after glucose uptake whereas plasma CXCL8 levels were significantly reduced.	Glucose	80-87	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
18789871-8	2008	In summary, these data indicate that oral glucose uptake in insulin-sensitive adults is associated with elevated monocytic and reduced systemic CXCL8.	Glucose	42-49	C-X-C motif chemokine ligand 8	Homo sapiens	144-149
18644822-9	2008	Steroids reduced inflammatory mediators (IL-6, IL-8 and CRP) and neutrophil activation whilst maintaining neutrophil phagocytic functions.	Steroids	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	47-59
18506470-10	2008	Inhibition of IL-8 expression by SP600125 suggests that JNK is involved in regulation of proinflammatory mediators of endometrium.	pyrazolanthrone	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
18644884-9	2008	The ability of the supernatant to induce IL-8 secretion was reduced by flagellum and cytolethal distending toxin (CDT) gene mutants, treatment of the supernatant with protease K or heat, or treatment of T84 cells with the Toll-like receptor (TLR) inhibitor MyD88 inhibitory peptide or chloroquine.	Chloroquine	285-296	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
18662984-2	2008	In this study, we demonstrate that inhibition of PI3K by wortmannin in neutrophil-like differentiated HL60 cells expressing CXCR2 resulted in reduced cell motility but normal chemotaxis in response to a gradient of CXCL8.	Wortmannin	57-67	C-X-C motif chemokine ligand 8	Homo sapiens	215-220
19377236-4	2008	The ratios of urinary IL-8 to creatinine (IL-8/C) before and after the treatment were compared with each other.	Creatinine	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	42-48
18664535-10	2008	Glucose-induced IL-1beta was biologically active and stimulated IL-8 release.	Glucose	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
18565136-0	2008	Irsogladine maleate abolishes the increase in interleukin-8 levels caused by outer membrane protein 29 from Aggregatibacter (Actinobacillus) actinomycetemcomitans through the ERK pathway in human gingival epithelial cells.	irsogladine	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	46-59
18565136-1	2008	BACKGROUND AND OBJECTIVE: Irsogladine maleate (IM) suppresses the increase in interleukin (IL)-8 production induced by outer membrane protein (OMP) 29 from Aggregatibacter (Actinobacillus) actinomycetemcomitans in cultures of human gingival epithelial cells (HGEC).	irsogladine	26-45	C-X-C motif chemokine ligand 8	Homo sapiens	78-96
18565136-7	2008	RESULTS: An ERK inhibitor, PD98059, as well as IM, obviated the OMP29-induced increase in IL-8 levels in HGEC.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	27-34	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
18282785-4	2008	Overexpression of CXCL8 in HN4 primary tumor cells with low endogenous CXCL8 levels was found to increase cell growth, as judged by cell counting and MTT assays.	monooxyethylene trimethylolpropane tristearate	150-153	C-X-C motif chemokine ligand 8	Homo sapiens	18-23
18974961-4	2008	To investigate the role of ROS in pathogenesis of periodontitis, we estimated the effect of H(2)O(2), one of ROS, on the expression of IL-8 in human periodontal ligament (PDL) cells.	Reactive Oxygen Species	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
18974961-4	2008	To investigate the role of ROS in pathogenesis of periodontitis, we estimated the effect of H(2)O(2), one of ROS, on the expression of IL-8 in human periodontal ligament (PDL) cells.	Reactive Oxygen Species	109-112	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
18974961-8	2008	Treatment with H(2)O(2) at concentration of up to 250 microM increased IL-8 mRNA expression and production in a concentration-dependent manner.	Hydrogen Peroxide	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
18974961-10	2008	Catalase, an inhibitor of H(2)O(2), down-regulated the production of IL-8 induced by H(2)O(2).	Water	26-31	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
18974961-10	2008	Catalase, an inhibitor of H(2)O(2), down-regulated the production of IL-8 induced by H(2)O(2).	Water	85-90	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
18974961-12	2008	Pretreatment with PD98059 (ERK inhibitor), SB203580 (p38 inhibitor), or SP600125 (JNK inhibitor) decreased the IL-8 production induced by H(2)O(2).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	18-25	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
18974961-12	2008	Pretreatment with PD98059 (ERK inhibitor), SB203580 (p38 inhibitor), or SP600125 (JNK inhibitor) decreased the IL-8 production induced by H(2)O(2).	SB 203580	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
18974961-12	2008	Pretreatment with PD98059 (ERK inhibitor), SB203580 (p38 inhibitor), or SP600125 (JNK inhibitor) decreased the IL-8 production induced by H(2)O(2).	pyrazolanthrone	72-80	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
18974961-13	2008	These results indicate that H(2)O(2) acts as an inducer of IL-8 secretion via activation of ERK, p38, and JNK in PDL cells.	Hydrogen Peroxide	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
18662984-3	2008	However, wortmannin inhibition of PI3K did impair the ability of cells to re-orient their polarity and respond quickly to a change in the direction of the CXCL8 gradient.	Wortmannin	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	155-160
18662758-4	2008	The results show that H(2)O(2) and quartz exposure induced almost identical levels of CXCL8 (interleukin-8) release in the alveolar epithelial cell line A549, but in the bronchial epithelial cell line BEAS-2B, H(2)O(2)-exposure did not affect CXCL8 release significantly, whereas quartz induced a 16-fold increase.	Hydrogen Peroxide	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	86-91
18662758-4	2008	The results show that H(2)O(2) and quartz exposure induced almost identical levels of CXCL8 (interleukin-8) release in the alveolar epithelial cell line A549, but in the bronchial epithelial cell line BEAS-2B, H(2)O(2)-exposure did not affect CXCL8 release significantly, whereas quartz induced a 16-fold increase.	Hydrogen Peroxide	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	93-106
18662758-4	2008	The results show that H(2)O(2) and quartz exposure induced almost identical levels of CXCL8 (interleukin-8) release in the alveolar epithelial cell line A549, but in the bronchial epithelial cell line BEAS-2B, H(2)O(2)-exposure did not affect CXCL8 release significantly, whereas quartz induced a 16-fold increase.	Hydrogen Peroxide	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	243-248
18615482-7	2008	RESULTS: Selective zinc deficiency induced by the membrane-permeable zinc chelator N,N,N",N"-tetrakis(2-pyridylmethyl)-ethylenediamine (TPEN) increases activation of NF-kappaB and up-regulates expression of the NF-kappaB controlled pro-angiogenic and pro-metastatic cytokines VEGF, IL-6 and IL-8 in androgen-independent PC-3 and DU-145 prostate cancer cells.	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	136-140	C-X-C motif chemokine ligand 8	Homo sapiens	291-295
18586957-3	2008	IL-1beta-induced IL-8 release was also repressed by PGE(2) and forskolin, whereas the beta(2)-adrenoceptor agonists were ineffective.	Prostaglandins E	52-55	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
18599499-0	2008	Double-stranded RNA-activated protein kinase mediates induction of interleukin-8 expression by deoxynivalenol, Shiga toxin 1, and ricin in monocytes.	deoxynivalenol	95-109	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
18599499-5	2008	Preincubation of human monocytic U937 cells with the PKR inhibitors C16 and 2-aminopurine (2-AP) blocked DON-induced expression of IL-8 protein and mRNA.	Palmitic Acid	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
18599499-5	2008	Preincubation of human monocytic U937 cells with the PKR inhibitors C16 and 2-aminopurine (2-AP) blocked DON-induced expression of IL-8 protein and mRNA.	2-Aminopurine	76-89	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
18599499-5	2008	Preincubation of human monocytic U937 cells with the PKR inhibitors C16 and 2-aminopurine (2-AP) blocked DON-induced expression of IL-8 protein and mRNA.	2-Aminopurine	91-95	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
18599499-5	2008	Preincubation of human monocytic U937 cells with the PKR inhibitors C16 and 2-aminopurine (2-AP) blocked DON-induced expression of IL-8 protein and mRNA.	deoxynivalenol	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
18599499-7	2008	Nuclear factor-kappa B binding, which has been previously shown to be a requisite for DON-induced IL-8 transcription, was markedly reduced in UK9M cells as compared with UK9C cells.	deoxynivalenol	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
18599499-8	2008	As observed for DON, ricin-, and Stx1-induced IL-8 expression was suppressed by the PKR inhibitors C16 and 2-AP as well as impaired in UK9M cells.	deoxynivalenol	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
18599499-8	2008	As observed for DON, ricin-, and Stx1-induced IL-8 expression was suppressed by the PKR inhibitors C16 and 2-AP as well as impaired in UK9M cells.	2-Aminopurine	107-111	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
18599499-9	2008	Taken together, these data indicate that PKR plays a common role in IL-8 induction by DON and the two RIPs, suggesting that this kinase might be a critical factor in RSR.	deoxynivalenol	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
18403779-10	2008	AG1478 (EGFR inhibitor) restored normal TLR4/2 levels and also suppressed synergistic release of IL-8.	RTKI cpd	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
18926057-3	2008	The aim of this study was to investigate the effects of these two antihistamines (cetirizine and levocetirizine) on granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-8 secretion in A549 human airway epithelial cells.	Cetirizine	82-92	C-X-C motif chemokine ligand 8	Homo sapiens	178-196
18926057-3	2008	The aim of this study was to investigate the effects of these two antihistamines (cetirizine and levocetirizine) on granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-8 secretion in A549 human airway epithelial cells.	levocetirizine	97-111	C-X-C motif chemokine ligand 8	Homo sapiens	178-196
18926057-7	2008	Cetirizine (10 microM) and levocetirizine (5 and 10 microM) significantly suppressed IL-8 secretion after A549 was stimulated.	Cetirizine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
18926057-7	2008	Cetirizine (10 microM) and levocetirizine (5 and 10 microM) significantly suppressed IL-8 secretion after A549 was stimulated.	levocetirizine	27-41	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
18926057-9	2008	Moreover, levocetirizine, 5 microM, was better than cetirizine, 5 microM, on suppressing IL-8 secretion, but such a difference did not appear in other conditions.	levocetirizine	10-24	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
18926057-9	2008	Moreover, levocetirizine, 5 microM, was better than cetirizine, 5 microM, on suppressing IL-8 secretion, but such a difference did not appear in other conditions.	Cetirizine	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
18586957-3	2008	IL-1beta-induced IL-8 release was also repressed by PGE(2) and forskolin, whereas the beta(2)-adrenoceptor agonists were ineffective.	Colforsin	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
18926057-10	2008	Our results suggest that cetirizine and levocetirizine at higher concentrations can reduce the release of GM-CSF and IL-8 from A549 cells stimulated with IL-1beta.	Cetirizine	25-35	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
18926057-10	2008	Our results suggest that cetirizine and levocetirizine at higher concentrations can reduce the release of GM-CSF and IL-8 from A549 cells stimulated with IL-1beta.	levocetirizine	40-54	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
18765195-10	2008	BAL IL-8 levels were higher in the SAL-3 group compared with the PER-3 group.	sal	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
18377686-8	2008	Ellagic acid, genistein and epigallocatechin gallate reduced (4- to 8-fold) IL-1beta-induced IL-8 secretion, while resveratrol promoted (1.7-fold) the secretion.	Ellagic Acid	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
18377686-8	2008	Ellagic acid, genistein and epigallocatechin gallate reduced (4- to 8-fold) IL-1beta-induced IL-8 secretion, while resveratrol promoted (1.7-fold) the secretion.	Genistein	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
18377686-8	2008	Ellagic acid, genistein and epigallocatechin gallate reduced (4- to 8-fold) IL-1beta-induced IL-8 secretion, while resveratrol promoted (1.7-fold) the secretion.	epigallocatechin gallate	28-52	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
18841306-13	2008	In an assay to determine inhibition of the H2O2-activated release of PGE2, IL-6, and IL-8 in human normal fibroblast cell lines, the release of PGE2 and IL-6 was almost completely inhibited above concentrations of 0.05% and 1%, respectively.	Hydrogen Peroxide	43-47	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
18841306-13	2008	In an assay to determine inhibition of the H2O2-activated release of PGE2, IL-6, and IL-8 in human normal fibroblast cell lines, the release of PGE2 and IL-6 was almost completely inhibited above concentrations of 0.05% and 1%, respectively.	Dinoprostone	144-148	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
18786233-11	2008	Our findings demonstrate the IL23/IL17 axis to be involved in the pathophysiology of BOS potentially triggering the IL8-mediated neutrophilia.	N-[4-(Aminosulfonyl)phenyl]-2-Mercaptobenzamide	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
18506912-0	2008	Changes in IL-8 release and intracellular content in DMSO-differentiated HL-60 cells after treatment with 4-hydroxynonenal.	Dimethyl Sulfoxide	53-57	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
18506912-0	2008	Changes in IL-8 release and intracellular content in DMSO-differentiated HL-60 cells after treatment with 4-hydroxynonenal.	4-hydroxy-2-nonenal	106-122	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
18506912-2	2008	In this work we studied HNE effects on the intracellular content of IL-8 and its release in DMSO-differentiated HL-60 cells.	Dimethyl Sulfoxide	92-96	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
18506912-5	2008	The addition of 0.1 microM IL-8 to DMSO-differentiated HL-60 cells induced a strong increase of exocytosis, measured by beta-glucuronidase secretion.	Dimethyl Sulfoxide	35-39	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
18341570-0	2008	Tetracycline suppresses ATP gamma S-induced CXCL8 and CXCL1 production by the human dermal microvascular endothelial cell-1 (HMEC-1) cell line and primary human dermal microvascular endothelial cells.	Tetracycline	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	44-49
18341570-0	2008	Tetracycline suppresses ATP gamma S-induced CXCL8 and CXCL1 production by the human dermal microvascular endothelial cell-1 (HMEC-1) cell line and primary human dermal microvascular endothelial cells.	adenosine 5'-O-(3-thiotriphosphate)	24-35	C-X-C motif chemokine ligand 8	Homo sapiens	44-49
18341570-6	2008	TCN dose-dependently inhibited ATP gamma S-induced augmentation of CXCL8 (interleukin-8) and CXCL1 (growth-regulated oncogene-alpha) production by HMEC-1 cells and primary human dermal endothelial cells in vitro.	Tetracyclines	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	67-72
18341570-6	2008	TCN dose-dependently inhibited ATP gamma S-induced augmentation of CXCL8 (interleukin-8) and CXCL1 (growth-regulated oncogene-alpha) production by HMEC-1 cells and primary human dermal endothelial cells in vitro.	Tetracyclines	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
18341570-6	2008	TCN dose-dependently inhibited ATP gamma S-induced augmentation of CXCL8 (interleukin-8) and CXCL1 (growth-regulated oncogene-alpha) production by HMEC-1 cells and primary human dermal endothelial cells in vitro.	adenosine 5'-O-(3-thiotriphosphate)	31-42	C-X-C motif chemokine ligand 8	Homo sapiens	67-72
18341570-6	2008	TCN dose-dependently inhibited ATP gamma S-induced augmentation of CXCL8 (interleukin-8) and CXCL1 (growth-regulated oncogene-alpha) production by HMEC-1 cells and primary human dermal endothelial cells in vitro.	adenosine 5'-O-(3-thiotriphosphate)	31-42	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
18613793-8	2008	In addition, compared with the CP group, in the CTU group the balance between proinflammatory mediators (such as tumor necrosis factor-alpha, interleukin [IL]-1beta, IL-6, and IL-8) and anti-inflammatory cytokines (including IL-4 and IL-10) was better modulated, and the cumulative survival rate of the CTU group exceeded that of the CP group by 17.8% at day 28, 25.9% at day 60, and 27.4% at day 90.	3,9-Bis(2-cyanoethyl)-2,4,8,10-tetraoxaspiro[5.5]undecane	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
18768046-11	2008	Lung tissue homogenate in the methylprednisolone group had lower levels of TNF-alpha (P &lt; 0.05), IL-1beta (P &lt; 0.05), and IL-8 (P &lt; 0.05) in both the collapsed and the ventilated lungs.	Methylprednisolone	30-48	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
18574003-3	2008	This 4-PBA-induced IL-8 production was associated with a strong reduction of proteasome and nuclear factor-kappaB transcriptional activities in the two DeltaF508-CFTR lung cells either in a resting state or after tumor necrosis factor-alpha stimulation.	4-phenylbutyric acid	5-10	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
18574003-7	2008	Therefore, we suggest that inhibition of both ERK1/2 and JNK signaling may be a means to strongly reduce 4-PBA-induced IL-8 production in combination with 4-PBA treatment to restore CFTR Cl(-) channel function in lung epithelial cells of patients with CF.	4-phenylbutyric acid	105-110	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
18790747-5	2008	Pretreatment with the CXCR2 antagonist AZ10397767 significantly attenuated IL-8-induced c-FLIP mRNA up-regulation whereas inhibition of androgen receptor- and/or nuclear factor-kappaB-mediated transcription attenuated IL-8-induced c-FLIP expression in LNCaP and PC3 cells, respectively.	AZ10397767	39-49	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
18600309-0	2008	Salmeterol with fluticasone enhances the suppression of IL-8 release and increases the translocation of glucocorticoid receptor by human neutrophils stimulated with cigarette smoke.	Salmeterol Xinafoate	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
18600309-0	2008	Salmeterol with fluticasone enhances the suppression of IL-8 release and increases the translocation of glucocorticoid receptor by human neutrophils stimulated with cigarette smoke.	Fluticasone	16-27	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
18600309-2	2008	Recently, we have demonstrated that combination of salmeterol and fluticasone propionate (FP) additionally suppress the production of IL-8 by human monocyte.	Salmeterol Xinafoate	51-61	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
18600309-2	2008	Recently, we have demonstrated that combination of salmeterol and fluticasone propionate (FP) additionally suppress the production of IL-8 by human monocyte.	Fluticasone	66-88	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
18600309-6	2008	Cigarette smoke medium (CSM) induces an increased expression of CXC receptors and the production of ROS that may explain the strong production of IL-8 by neutrophils.	Reactive Oxygen Species	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
18493738-9	2008	RESULTS: Physiological concentrations of C-peptide affect high glucose-induced endothelial dysfunction by: (1) decreasing VCAM-1 expression and U-937 cell adherence to HAEC; (2) reducing secretion of IL-8 and MCP-1; and (3) suppressing NF-kappaB activation.	Glucose	63-70	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
18617548-9	2008	TCDD up-regulated the expression of IL-1beta, IL-6 and IL-8 through binding to AhR, and this effect was transmitted via the NF-kappaB and ERK signalling cascades.	Polychlorinated Dibenzodioxins	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
18662754-6	2008	The induction of IL-8 by titanium dioxide nanoparticles was inhibited by the pre-treatment with SB203580 and PD98059, which means that the IL-8 was induced through p38 mitogen-activated protein kinase (MAPK) pathway and/or extracellular signal (ERK) pathway.	titanium dioxide	25-41	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
18662754-6	2008	The induction of IL-8 by titanium dioxide nanoparticles was inhibited by the pre-treatment with SB203580 and PD98059, which means that the IL-8 was induced through p38 mitogen-activated protein kinase (MAPK) pathway and/or extracellular signal (ERK) pathway.	titanium dioxide	25-41	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
18662754-6	2008	The induction of IL-8 by titanium dioxide nanoparticles was inhibited by the pre-treatment with SB203580 and PD98059, which means that the IL-8 was induced through p38 mitogen-activated protein kinase (MAPK) pathway and/or extracellular signal (ERK) pathway.	SB 203580	96-104	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
18662754-6	2008	The induction of IL-8 by titanium dioxide nanoparticles was inhibited by the pre-treatment with SB203580 and PD98059, which means that the IL-8 was induced through p38 mitogen-activated protein kinase (MAPK) pathway and/or extracellular signal (ERK) pathway.	SB 203580	96-104	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
18662754-6	2008	The induction of IL-8 by titanium dioxide nanoparticles was inhibited by the pre-treatment with SB203580 and PD98059, which means that the IL-8 was induced through p38 mitogen-activated protein kinase (MAPK) pathway and/or extracellular signal (ERK) pathway.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	109-116	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
18662754-6	2008	The induction of IL-8 by titanium dioxide nanoparticles was inhibited by the pre-treatment with SB203580 and PD98059, which means that the IL-8 was induced through p38 mitogen-activated protein kinase (MAPK) pathway and/or extracellular signal (ERK) pathway.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	109-116	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
18501560-5	2008	Leptin-mediated IL-8 production was attenuated by OBRl receptor antisense oligonucleotide, JAK2 inhibitor or STAT3 small interference RNA (siRNA).	Oligonucleotides	74-89	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
18501560-8	2008	Moreover, pretreatment with p300 inhibitor (curcumin) also blocked IL-8 expression.	Curcumin	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
18501560-9	2008	The binding of p65 to the NF-kappaB elements, as well as the recruitment of p300 and the enhancement of histone H3 acetylation on the IL-8 promoter was enhanced by leptin, which was inhibited by wortmannin, Akt inhibitor or IRS-1 siRNA.	Wortmannin	195-205	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
18688536-3	2008	Quantitative polarization analysis of the measured SHG data indicated that the average orientation of the interfacial water molecules changed only slightly around 40 degrees with the increase of the bulk concentration of the three sodium halides, namely NaF, NaCl and NaBr, from that of the neat air/water interface.	Water	118-123	C-X-C motif chemokine ligand 8	Homo sapiens	254-257
18688536-3	2008	Quantitative polarization analysis of the measured SHG data indicated that the average orientation of the interfacial water molecules changed only slightly around 40 degrees with the increase of the bulk concentration of the three sodium halides, namely NaF, NaCl and NaBr, from that of the neat air/water interface.	sodium halides	231-245	C-X-C motif chemokine ligand 8	Homo sapiens	254-257
18688536-4	2008	The observed significant SHG signal increase with the bulk salt concentration is attributed to the overall increase of the thickness of the interfacial water molecular layer, following the order of NaBr &gt; NaCl approximately NaF.	Salts	59-63	C-X-C motif chemokine ligand 8	Homo sapiens	227-230
18688536-4	2008	The observed significant SHG signal increase with the bulk salt concentration is attributed to the overall increase of the thickness of the interfacial water molecular layer, following the order of NaBr &gt; NaCl approximately NaF.	Water	152-157	C-X-C motif chemokine ligand 8	Homo sapiens	227-230
18485432-0	2008	Hypo-responsiveness of interleukin-8 production in human embryonic epithelial intestine 407 cells independent of NF-kappaB pathway: new lessons from endotoxin and ribotoxic deoxynivalenol.	deoxynivalenol	173-187	C-X-C motif chemokine ligand 8	Homo sapiens	23-36
18485432-4	2008	Taking the knowledge into consideration, we tested the hypothesis that endotoxin pre-exposure can attenuate ribotoxin-induced epithelial interleukin-8 (IL-8) production via a tolerance mechanism.	ribotoxin	108-117	C-X-C motif chemokine ligand 8	Homo sapiens	137-150
18485432-4	2008	Taking the knowledge into consideration, we tested the hypothesis that endotoxin pre-exposure can attenuate ribotoxin-induced epithelial interleukin-8 (IL-8) production via a tolerance mechanism.	ribotoxin	108-117	C-X-C motif chemokine ligand 8	Homo sapiens	152-156
18660424-9	2008	Poly(I:C)-induced expression of IL-6, IL-8, G-CSF, MIP-1beta, exotaxin, RANTES, and ICAM-1 was inhibited differentially by the MAPK inhibitors PD98059 and SB203580 and by JNK inhibitor II.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
18636175-0	2008	Glucosamine suppresses interleukin-8 production and ICAM-1 expression by TNF-alpha-stimulated human colonic epithelial HT-29 cells.	Glucosamine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	23-36
18636175-4	2008	The results revealed that glucosamine suppressed the IL-8 production and ICAM-1 expression by TNF-alpha-activated HT-29 cells.	Glucosamine	26-37	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
18636175-6	2008	Thus, glucosamine demonstrates inhibitory actions on the inflammatory and signaling molecules (IL-8, ICAM-1, p38MAPK and NF-kappaB) in intestinal epithelial cells.	Glucosamine	6-17	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
18664347-11	2008	The change of IL-8 level before and after treatment in Tanreqing group was greater than that in ambroxol hydrochloride group and the control group.	Ambroxol	96-118	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
18729741-4	2008	Cycloheximide treatment indicated that the augmenting effect of CSC on IL-1alpha, IL-1beta and IL-8, but not IL-6 and CYP1A1, mRNA expression requires de novo protein synthesis.	Cycloheximide	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
18660424-7	2008	RESULTS: Poly(I:C) induced the up-regulation of TLR3, the release of IL-6, IL-8, G-CSF, MIP-1beta, eotaxin, and RANTES, and the expression of ICAM-1 and VCAM-1 in corneal fibroblasts.	Poly I-C	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
18656796-7	2008	Furthermore, bile acid levels, but not pepsin levels, correlated positively with BAL neutrophilia and IL-8 protein levels.	Bile Acids and Salts	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
18656796-9	2008	This relationship between reflux and airway colonization and their role in the development of chronic allograft dysfunction/BOS after LTx should be further elucidated; nevertheless, induction of IL-8-mediated neutrophilic airway inflammation may be a putative mechanism.	Leukotriene C4	134-137	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
19967052-5	2008	HSP22-induced IL-8 release was inhibited by U0126, but not by SB202190.	U 0126	44-49	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
18074179-10	2008	RESULTS: Exposure to 100% CO(2) completely blocked spontaneous and IL-8 induced migration of PMNs (p &lt; 0.001 vs. controls).	Carbon Dioxide	26-31	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
18508130-1	2008	The chemokine interleukin 8/CXCL8 induces the phosphorylation of the GluR1 subunit of the AMPA-type glutamate receptor in neurons and transfected HEK cells, on both serine 845 (S845) and 831 (S831) residues.	Serine	165-171	C-X-C motif chemokine ligand 8	Homo sapiens	28-33
18502748-5	2008	We found that exposure of RPE cells to H(2)O(2), paraquat, or A2E-mediated photooxidation resulted in increased expression and secretion of IL-8.	Paraquat	49-57	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
18655734-14	2008	After immersion in the NaF solution, fluoride concentrations at the surfaces of the disks increased when compared with previous storage media (FT&gt;FVIII&gt;KN&gt;FII&gt;FIX).	Fluorides	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
18487355-14	2008	Whereas clarithromycin, azithromycin, and moxifloxacin individually were able to inhibit TNF-alpha-induction of IL-8, each failed to inhibit MMF-induction of IL-8.	Clarithromycin	8-22	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
18571505-5	2008	Adding AG1296 with RA increased secretion of TNF-alpha, IL-8, and MMP-9 expression.	6,7-dimethoxy-3-phenylquinoxaline	7-13	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
18571505-5	2008	Adding AG1296 with RA increased secretion of TNF-alpha, IL-8, and MMP-9 expression.	Tretinoin	19-21	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
18468509-3	2008	Additionally, rhLIGHT was found to increase ROS via NADPH oxidase p47(phox) phosphorylation, which was found to be required for LIGHT-induced NF-kappaB activation, CCR1 and CCR2 expression, migration and IL-8 and TNF-alpha production.	Reactive Oxygen Species	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
18487355-14	2008	Whereas clarithromycin, azithromycin, and moxifloxacin individually were able to inhibit TNF-alpha-induction of IL-8, each failed to inhibit MMF-induction of IL-8.	Azithromycin	24-36	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
18487355-14	2008	Whereas clarithromycin, azithromycin, and moxifloxacin individually were able to inhibit TNF-alpha-induction of IL-8, each failed to inhibit MMF-induction of IL-8.	Moxifloxacin	42-54	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
18607537-7	2008	An IkappaB kinase 2 inhibitor, sc514, also strongly reduced IL-8 and significantly induced p53 protein levels.	SC 514	31-36	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
18580215-10	2008	Significant increases in systemic IL-6 and IL-8 values were measured only in patients undergoing DAP and SP.	dap	97-100	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
18580215-10	2008	Significant increases in systemic IL-6 and IL-8 values were measured only in patients undergoing DAP and SP.	TFF2 protein, human	105-107	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
18500358-9	2008	KEY RESULTS: EtP was several-fold more potent than EtOH in reducing adhesion of neutrophils to activated HUVECs, generation of IL-8 or G-CSF and surface expression of the adhesion molecules.	ethyl pyruvate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
18506884-6	2008	The mutually antagonistic relationship between IFN-gamma and PGE(2) extends to downstream cytokine and chemokine release; PGE(2) counters the effects of IFN-gamma, on the release of IP-10, IL-8, TNF-alpha and IL-1beta.	Prostaglandins E	122-125	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
18452717-6	2008	The combination of ROS quenching by the free radical scavenger Tempol and of Bcl10 silencing by siRNA completely inhibited the CGN-induced increases in nuclear NFkappaB (p65), phospho-IkappaBalpha, and secretion of IL-8.	Reactive Oxygen Species	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
18275043-11	2008	However, OGM-differentiated hMSCs showed an increase in CXCL8 levels when treated with the NF-kappaB inhibitor PDTC, a pyrrolidine derivative of dithiocarbamate.	pyrrolidine	119-130	C-X-C motif chemokine ligand 8	Homo sapiens	56-61
18275043-11	2008	However, OGM-differentiated hMSCs showed an increase in CXCL8 levels when treated with the NF-kappaB inhibitor PDTC, a pyrrolidine derivative of dithiocarbamate.	Dithiocarbamate	145-160	C-X-C motif chemokine ligand 8	Homo sapiens	56-61
18311596-2	2008	Here we demonstrate that cholesterol was absolutely required for polarized redistribution of key chemotactic mediators in human neutrophils in response to all chemoattractants tested (fMet-Leu-Phe, and the chemokines CXCL1, CXCL8 and CXCL12).	Cholesterol	25-36	C-X-C motif chemokine ligand 8	Homo sapiens	224-229
18566387-9	2008	cis-UCA also increased cytokine protein production such as that of TNF-alpha, IL-6, and IL-8 in a dose-dependent manner.	cis-Urocanic acid	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
19079193-7	2008	Estradiol also reversed the stimulatory effects of IL-1beta on mRNA expression of TNF-alpha, IL-8, and NF-kB by 85, 95, and 70%, respectively.	Estradiol	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
18830893-5	2008	PAH induced significant secretion of IL-1beta, IL-8, and IL-12 after 24 or 48 hr of treatment, an effect reinforced by LPS stimulation; no effect on IL-10 secretion was noted.	Polycyclic Aromatic Hydrocarbons	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
18603066-7	2008	RESULTS: Four-hour pretreatment markedly reduced inflammatory endothelial release of interleukin 8 (2587 +/- 82 pg/mL control vs 208 +/- 3 pg/mL omega-3 pretreated, P &lt; .01) and endothelial expression of intercellular adhesion molecule 1 (196.1 +/- 2.0 vs 71.9 +/- 0.6 mean channel fluorescence, P &lt; .01) in response to endotoxin and tumor necrosis factor a. Neutrophil activation (CD11b and respiratory burst) was maintained, but pretreated neutrophils had shorter survival.	Fatty Acids, Omega-3	145-152	C-X-C motif chemokine ligand 8	Homo sapiens	85-98
18515093-8	2008	LCA significantly decreased IL-8 secretion induced by IL-1beta.	Lithocholic Acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
18533267-5	2008	The generation of interleukin-8 (CXCL8/IL-8) by human DCs conditioned with CSE was suppressed by the anti-oxidant n-acetyl cysteine (NAC), implying the involvement of oxidant sensitive pathways as a primary mechanism involved in the enhanced CXCL8/IL-8 generation.	Acetylcysteine	114-131	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
18533267-5	2008	The generation of interleukin-8 (CXCL8/IL-8) by human DCs conditioned with CSE was suppressed by the anti-oxidant n-acetyl cysteine (NAC), implying the involvement of oxidant sensitive pathways as a primary mechanism involved in the enhanced CXCL8/IL-8 generation.	Acetylcysteine	114-131	C-X-C motif chemokine ligand 8	Homo sapiens	33-38
18533267-5	2008	The generation of interleukin-8 (CXCL8/IL-8) by human DCs conditioned with CSE was suppressed by the anti-oxidant n-acetyl cysteine (NAC), implying the involvement of oxidant sensitive pathways as a primary mechanism involved in the enhanced CXCL8/IL-8 generation.	Acetylcysteine	114-131	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
18533267-5	2008	The generation of interleukin-8 (CXCL8/IL-8) by human DCs conditioned with CSE was suppressed by the anti-oxidant n-acetyl cysteine (NAC), implying the involvement of oxidant sensitive pathways as a primary mechanism involved in the enhanced CXCL8/IL-8 generation.	Acetylcysteine	114-131	C-X-C motif chemokine ligand 8	Homo sapiens	242-247
18533267-5	2008	The generation of interleukin-8 (CXCL8/IL-8) by human DCs conditioned with CSE was suppressed by the anti-oxidant n-acetyl cysteine (NAC), implying the involvement of oxidant sensitive pathways as a primary mechanism involved in the enhanced CXCL8/IL-8 generation.	Acetylcysteine	114-131	C-X-C motif chemokine ligand 8	Homo sapiens	248-252
18533267-5	2008	The generation of interleukin-8 (CXCL8/IL-8) by human DCs conditioned with CSE was suppressed by the anti-oxidant n-acetyl cysteine (NAC), implying the involvement of oxidant sensitive pathways as a primary mechanism involved in the enhanced CXCL8/IL-8 generation.	Acetylcysteine	133-136	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
18533267-5	2008	The generation of interleukin-8 (CXCL8/IL-8) by human DCs conditioned with CSE was suppressed by the anti-oxidant n-acetyl cysteine (NAC), implying the involvement of oxidant sensitive pathways as a primary mechanism involved in the enhanced CXCL8/IL-8 generation.	Acetylcysteine	133-136	C-X-C motif chemokine ligand 8	Homo sapiens	33-38
18533267-5	2008	The generation of interleukin-8 (CXCL8/IL-8) by human DCs conditioned with CSE was suppressed by the anti-oxidant n-acetyl cysteine (NAC), implying the involvement of oxidant sensitive pathways as a primary mechanism involved in the enhanced CXCL8/IL-8 generation.	Acetylcysteine	133-136	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
18533267-5	2008	The generation of interleukin-8 (CXCL8/IL-8) by human DCs conditioned with CSE was suppressed by the anti-oxidant n-acetyl cysteine (NAC), implying the involvement of oxidant sensitive pathways as a primary mechanism involved in the enhanced CXCL8/IL-8 generation.	Acetylcysteine	133-136	C-X-C motif chemokine ligand 8	Homo sapiens	242-247
18533267-5	2008	The generation of interleukin-8 (CXCL8/IL-8) by human DCs conditioned with CSE was suppressed by the anti-oxidant n-acetyl cysteine (NAC), implying the involvement of oxidant sensitive pathways as a primary mechanism involved in the enhanced CXCL8/IL-8 generation.	Acetylcysteine	133-136	C-X-C motif chemokine ligand 8	Homo sapiens	248-252
18533267-7	2008	Whereas NAC suppressed production of CXCL8 by CSE-conditioned DCs, it augmented production of PGE2 and cellular COX-2 levels in maturing DCs.	Acetylcysteine	8-11	C-X-C motif chemokine ligand 8	Homo sapiens	37-42
21479441-4	2008	EGCG downregulated the levels of pro-inflammatory cytokine interleukin (IL)-6 and chemokines IL-8, monocyte-chemoattractant protein (MCP)-1 and RANTES.	epigallocatechin gallate	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
18767394-2	2008	LPS-induced IL-8 production in leukocyte fraction was inhibited by beta-endorphin 10(-7), 10(-11) M. The enchasing effect of beta-endorphin on IL-1beta production was not blocked by naloxone and naltrindole.	lps	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
18546154-6	2008	DCIP-selective antisense oligodeoxynucleotide inhibited the expression of TNF-alpha-responsive gene targets including vascular cell adhesion molecule-1, intercellular adhesion molecule-1, IL-6, IL-8, IP-10, and thymic stromal lymphopoietin.	dcip	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
18546154-6	2008	DCIP-selective antisense oligodeoxynucleotide inhibited the expression of TNF-alpha-responsive gene targets including vascular cell adhesion molecule-1, intercellular adhesion molecule-1, IL-6, IL-8, IP-10, and thymic stromal lymphopoietin.	Oligodeoxyribonucleotides	25-45	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
18767394-4	2008	In mononuclear and neutrophile fractions beta-endorphin and delta-agonist DADLE enchased IL-1beta production in spontaneous and LPS-stimulating cultures, when IL-8 production inhibited beta-endorphin and delta-agonist DADLE only in LPS presence.	lps	232-235	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
18767394-5	2008	No effect of mu-agonist DAGO were observed on IL-1beta production, whereas LPS-induced IL-8 secretion in neutrophile fraction inhibited by DAGO.	lps	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
18767394-2	2008	LPS-induced IL-8 production in leukocyte fraction was inhibited by beta-endorphin 10(-7), 10(-11) M. The enchasing effect of beta-endorphin on IL-1beta production was not blocked by naloxone and naltrindole.	Naloxone	182-190	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
18767394-2	2008	LPS-induced IL-8 production in leukocyte fraction was inhibited by beta-endorphin 10(-7), 10(-11) M. The enchasing effect of beta-endorphin on IL-1beta production was not blocked by naloxone and naltrindole.	naltrindole	195-206	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
18767394-3	2008	The inhibitory effect of beta-endorphin on IL-8 production was blocked by naloxone and naltrindole.	Naloxone	74-82	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
18767394-3	2008	The inhibitory effect of beta-endorphin on IL-8 production was blocked by naloxone and naltrindole.	naltrindole	87-98	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
18424663-5	2008	CBMCs responded to stimulation with polyinosinic.polycytidylic acid by producing a distinct chemokine profile, including CCL4, CXCL8, and CXCL10.	cbmcs	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	127-132
18424663-5	2008	CBMCs responded to stimulation with polyinosinic.polycytidylic acid by producing a distinct chemokine profile, including CCL4, CXCL8, and CXCL10.	Poly I-C	36-67	C-X-C motif chemokine ligand 8	Homo sapiens	127-132
18424663-6	2008	CBMCs produced significant amounts of CXCL8 in response to low levels of reovirus infection, while both skin- and lung-derived fibroblasts were unresponsive unless higher doses of reovirus were used.	cbmcs	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	38-43
18424663-7	2008	Supernatants from CBMCs infected with reovirus induced substantial NK cell chemotaxis that was highly dependent on CXCL8 and CXCR1.	cbmcs	18-23	C-X-C motif chemokine ligand 8	Homo sapiens	115-120
18390828-8	2008	IL-8/CXCL8 induction and ERK1/2 activation were preceded by EGF receptor (EGFR) tyrosine phosphorylation, within 2 min, and reduced by selective EGFR tyrosine kinase inhibitors (AG-1478 and PD168393) by a neutralizing EGFR antibody and by small interfering RNA oligonucleotides directed against EGFR, implicating EGFR activation.	RTKI cpd	178-185	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
18390828-3	2008	Stimulation with rhMMP-12 resulted in a concentration-dependent IL-8/CXCL8 synthesis 6 h later.	rhmmp-12	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
18390828-3	2008	Stimulation with rhMMP-12 resulted in a concentration-dependent IL-8/CXCL8 synthesis 6 h later.	rhmmp-12	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	69-74
18390828-5	2008	In A549 cells, synthetic matrix metalloproteinase (MMP) inhibitors prevented rhMMP-12-induced IL-8/CXCL8 release.	rhmmp-12	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
18390828-5	2008	In A549 cells, synthetic matrix metalloproteinase (MMP) inhibitors prevented rhMMP-12-induced IL-8/CXCL8 release.	rhmmp-12	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	99-104
18375743-9	2008	We conclude that multiple TLR ligands induce airway epithelial cell production of IL-8 and VEGF via a Duox1--&gt; ROS--&gt; TACE--&gt; TGF-alpha--&gt; EGFR phosphorylation pathway.	Reactive Oxygen Species	114-117	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
18390828-8	2008	IL-8/CXCL8 induction and ERK1/2 activation were preceded by EGF receptor (EGFR) tyrosine phosphorylation, within 2 min, and reduced by selective EGFR tyrosine kinase inhibitors (AG-1478 and PD168393) by a neutralizing EGFR antibody and by small interfering RNA oligonucleotides directed against EGFR, implicating EGFR activation.	RTKI cpd	178-185	C-X-C motif chemokine ligand 8	Homo sapiens	5-10
18390828-7	2008	Selective MEK inhibitors (U0126 and PD-98059) blocked both IL-8/CXCL8 release and ERK1/2 phosphorylation.	U 0126	26-31	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
18390828-7	2008	Selective MEK inhibitors (U0126 and PD-98059) blocked both IL-8/CXCL8 release and ERK1/2 phosphorylation.	U 0126	26-31	C-X-C motif chemokine ligand 8	Homo sapiens	64-69
18390828-8	2008	IL-8/CXCL8 induction and ERK1/2 activation were preceded by EGF receptor (EGFR) tyrosine phosphorylation, within 2 min, and reduced by selective EGFR tyrosine kinase inhibitors (AG-1478 and PD168393) by a neutralizing EGFR antibody and by small interfering RNA oligonucleotides directed against EGFR, implicating EGFR activation.	PD168393	190-198	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
18390828-7	2008	Selective MEK inhibitors (U0126 and PD-98059) blocked both IL-8/CXCL8 release and ERK1/2 phosphorylation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
18390828-7	2008	Selective MEK inhibitors (U0126 and PD-98059) blocked both IL-8/CXCL8 release and ERK1/2 phosphorylation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	64-69
18390828-8	2008	IL-8/CXCL8 induction and ERK1/2 activation were preceded by EGF receptor (EGFR) tyrosine phosphorylation, within 2 min, and reduced by selective EGFR tyrosine kinase inhibitors (AG-1478 and PD168393) by a neutralizing EGFR antibody and by small interfering RNA oligonucleotides directed against EGFR, implicating EGFR activation.	PD168393	190-198	C-X-C motif chemokine ligand 8	Homo sapiens	5-10
18390828-8	2008	IL-8/CXCL8 induction and ERK1/2 activation were preceded by EGF receptor (EGFR) tyrosine phosphorylation, within 2 min, and reduced by selective EGFR tyrosine kinase inhibitors (AG-1478 and PD168393) by a neutralizing EGFR antibody and by small interfering RNA oligonucleotides directed against EGFR, implicating EGFR activation.	Tyrosine	80-88	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
18390828-8	2008	IL-8/CXCL8 induction and ERK1/2 activation were preceded by EGF receptor (EGFR) tyrosine phosphorylation, within 2 min, and reduced by selective EGFR tyrosine kinase inhibitors (AG-1478 and PD168393) by a neutralizing EGFR antibody and by small interfering RNA oligonucleotides directed against EGFR, implicating EGFR activation.	Tyrosine	80-88	C-X-C motif chemokine ligand 8	Homo sapiens	5-10
18390828-8	2008	IL-8/CXCL8 induction and ERK1/2 activation were preceded by EGF receptor (EGFR) tyrosine phosphorylation, within 2 min, and reduced by selective EGFR tyrosine kinase inhibitors (AG-1478 and PD168393) by a neutralizing EGFR antibody and by small interfering RNA oligonucleotides directed against EGFR, implicating EGFR activation.	Oligonucleotides	261-277	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
18390828-8	2008	IL-8/CXCL8 induction and ERK1/2 activation were preceded by EGF receptor (EGFR) tyrosine phosphorylation, within 2 min, and reduced by selective EGFR tyrosine kinase inhibitors (AG-1478 and PD168393) by a neutralizing EGFR antibody and by small interfering RNA oligonucleotides directed against EGFR, implicating EGFR activation.	Oligonucleotides	261-277	C-X-C motif chemokine ligand 8	Homo sapiens	5-10
18390828-10	2008	Using small interfering technique, we showed that c-Fos is involved in rhMMP-12-induced IL-8/CXCL8 production.	rhmmp-12	71-79	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
18390828-10	2008	Using small interfering technique, we showed that c-Fos is involved in rhMMP-12-induced IL-8/CXCL8 production.	rhmmp-12	71-79	C-X-C motif chemokine ligand 8	Homo sapiens	93-98
18486963-5	2008	This enhancement is attributed to the formation of complex compounds between EDTA/NaF and reaction products, such as Cr(III) and Fe(III), which eliminate the precipitates of Cr(III), Fe(III) hydroxides and Cr(x)Fe(1-)(x)(OH)(3) and thus reduce surface passivation of Fe(0).	Edetic Acid	77-81	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
18563354-7	2008	The reduced adhesion by EPS was correlated with suppressed expression of MCP-1 and IL-8, the major chemokines in IBD.	eps	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
18487223-4	2008	Blockade of CXC chemokine receptor-2 signaling using a small molecule antagonist (AZ10397767) attenuated the IL-8-induced increases in AR expression and transcriptional activity.	AZ10397767	82-92	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
18487223-7	2008	In addition, our data show that IL-8-promoted regulation of the AR attenuates the effectiveness of the AR antagonist bicalutamide in reducing CaP cell viability.	bicalutamide	117-129	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
18486963-5	2008	This enhancement is attributed to the formation of complex compounds between EDTA/NaF and reaction products, such as Cr(III) and Fe(III), which eliminate the precipitates of Cr(III), Fe(III) hydroxides and Cr(x)Fe(1-)(x)(OH)(3) and thus reduce surface passivation of Fe(0).	tris(1,10-phenanthroline)chromium(III) chloride	117-124	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
18486963-5	2008	This enhancement is attributed to the formation of complex compounds between EDTA/NaF and reaction products, such as Cr(III) and Fe(III), which eliminate the precipitates of Cr(III), Fe(III) hydroxides and Cr(x)Fe(1-)(x)(OH)(3) and thus reduce surface passivation of Fe(0).	ferric sulfate	129-136	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
18486963-5	2008	This enhancement is attributed to the formation of complex compounds between EDTA/NaF and reaction products, such as Cr(III) and Fe(III), which eliminate the precipitates of Cr(III), Fe(III) hydroxides and Cr(x)Fe(1-)(x)(OH)(3) and thus reduce surface passivation of Fe(0).	tris(1,10-phenanthroline)chromium(III) chloride	174-181	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
18486963-5	2008	This enhancement is attributed to the formation of complex compounds between EDTA/NaF and reaction products, such as Cr(III) and Fe(III), which eliminate the precipitates of Cr(III), Fe(III) hydroxides and Cr(x)Fe(1-)(x)(OH)(3) and thus reduce surface passivation of Fe(0).	fe(iii) hydroxides	183-201	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
18486963-5	2008	This enhancement is attributed to the formation of complex compounds between EDTA/NaF and reaction products, such as Cr(III) and Fe(III), which eliminate the precipitates of Cr(III), Fe(III) hydroxides and Cr(x)Fe(1-)(x)(OH)(3) and thus reduce surface passivation of Fe(0).	Chromium	117-119	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
18486963-5	2008	This enhancement is attributed to the formation of complex compounds between EDTA/NaF and reaction products, such as Cr(III) and Fe(III), which eliminate the precipitates of Cr(III), Fe(III) hydroxides and Cr(x)Fe(1-)(x)(OH)(3) and thus reduce surface passivation of Fe(0).	Iron	129-131	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
18622147-0	2008	[Association between raised IL-8 serum levels and resistance to combined peg-interferon plus ribavirin therapy in HCV+ active chronic hepatitis].	Ribavirin	93-102	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
18514500-6	2008	High chlorobenzene concentrations (100 g/m(3)) induced IL-8 production in A549 cells, whereby lower concentrations (10 microg/m(3)-1 g/m(3)) stimulated the secretion of the monocyte chemoattractant protein-1 (MCP-1).	chlorobenzene	5-18	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
18000644-11	2008	CONCLUSIONS: mRNA expression levels of IL-8 and GSK-3beta correlate with antitumor activity of enzastaurin.	enzastaurin	95-106	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
18622147-7	2008	Serum IL-8 can be considered and proposed as a non-invasive and predictive marker of response to combined PEG IFN alpha2b + Ribavirin in CAH HCV +.	Polyethylene Glycols	106-109	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
18622147-7	2008	Serum IL-8 can be considered and proposed as a non-invasive and predictive marker of response to combined PEG IFN alpha2b + Ribavirin in CAH HCV +.	Ribavirin	124-133	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
18363812-8	2008	IL10 and SU6656 had no effect on PMA formation, although both significantly reduced TF (P = 0.002 and P = 0.02) and IL8 (P = 0.009 and P = 0.001) mRNA upon TRAP and P-selectin stimulation.	SU 6656	9-15	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
18598184-8	2008	Resveratrol at concentrations &gt; or =50 micromol/mL significantly inhibited IL-8 and IL-6 production.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
18598184-10	2008	Quercetin 3"-sulfate, at 25 micromol/mL, inhibited IL-8 and IL-6 production.	quercetin 3'-sulfate	0-20	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
18473409-12	2008	CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8.	Mesalamine	47-57	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
18535989-9	2008	Quantitative reverse-transcriptase polymerase chain reaction (qRTPCR) of IL-8 mRNA shows increased expression in the high-dose RNT-treated groups at both 1 and 6 h, while an adhesion molecule, ICAM-1 mRNA, shows the greatest increase at 6 h in the QM-treated group.	glutaminylmethionine	248-250	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
18433103-5	2008	Stevioside (2 mM) potentiated TNF-alpha-mediated IL-8 release in T84 cells.	stevioside	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
18433103-6	2008	However, steviol (0.01-0.2 mM) significantly suppressed TNF-alpha-induced IL-8 release in all three cell lines.	steviol	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
18433103-9	2008	Two biological effects of steviol in the colon are demonstrated for the first time: stimulation of Cl(-) secretion and attenuation of TNF-alpha-stimulated IL-8 production.	steviol	26-33	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
18294142-1	2008	We have demonstrated that LPA (lysophosphatidic acid)-induced IL (interleukin)-8 secretion was partly mediated via transactivation of EGFR [EGF (epidermal growth factor) receptor] in HBEpCs (human bronchial epithelial primary cells).	lysophosphatidic acid	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	62-80
18294142-1	2008	We have demonstrated that LPA (lysophosphatidic acid)-induced IL (interleukin)-8 secretion was partly mediated via transactivation of EGFR [EGF (epidermal growth factor) receptor] in HBEpCs (human bronchial epithelial primary cells).	lysophosphatidic acid	31-52	C-X-C motif chemokine ligand 8	Homo sapiens	62-80
18569862-4	2008	In the present study, we show that human peripheral blood mononuclear cells (PBMC) co-cultured with PG, in the presence of the inflammatory activator lipopolysaccharide, secreted higher amounts of pro-inflammatory and pro-angiogenic cytokines, such as interleukin (IL)-1beta, IL-6 and IL-8.	pg	100-102	C-X-C motif chemokine ligand 8	Homo sapiens	285-289
18245149-7	2008	In contrast, infectious rhinovirus impaired lipopolysaccharide and lipoteichoic acid induced TNFalpha and IL8 secretion by macrophages.	lipoteichoic acid	67-84	C-X-C motif chemokine ligand 8	Homo sapiens	106-109
18444659-0	2008	5-caffeoylquinic acid and caffeic acid down-regulate the oxidative stress- and TNF-alpha-induced secretion of interleukin-8 from Caco-2 cells.	5'-O-caffeoylquinic acid	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	110-123
18444659-0	2008	5-caffeoylquinic acid and caffeic acid down-regulate the oxidative stress- and TNF-alpha-induced secretion of interleukin-8 from Caco-2 cells.	caffeic acid	26-38	C-X-C motif chemokine ligand 8	Homo sapiens	110-123
18444659-2	2008	We investigated in this study the down-regulative effects of 5-caffeoylquinic acid (CQA), the predominant isomer of CHA, on the H(2)O(2-) or TNF-alpha-induced secretion of interleukin (IL)-8, a central pro-inflammatory chemokine involved in the pathogenesis of inflammatory bowel diseases, in human intestinal epithelial Caco-2 cells.	5'-O-caffeoylquinic acid	61-82	C-X-C motif chemokine ligand 8	Homo sapiens	172-190
18444659-2	2008	We investigated in this study the down-regulative effects of 5-caffeoylquinic acid (CQA), the predominant isomer of CHA, on the H(2)O(2-) or TNF-alpha-induced secretion of interleukin (IL)-8, a central pro-inflammatory chemokine involved in the pathogenesis of inflammatory bowel diseases, in human intestinal epithelial Caco-2 cells.	Amodiaquine	84-87	C-X-C motif chemokine ligand 8	Homo sapiens	172-190
18444659-3	2008	After the cells had been pre- and simultaneously treated with CQA, the oversecretion of IL-8 and overexpression of its mRNA induced by H(2)O(2) were significantly suppressed in a dose-dependent manner in the range of 0.25-2.00 mmol/L.	Amodiaquine	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
18444659-3	2008	After the cells had been pre- and simultaneously treated with CQA, the oversecretion of IL-8 and overexpression of its mRNA induced by H(2)O(2) were significantly suppressed in a dose-dependent manner in the range of 0.25-2.00 mmol/L.	Hydrogen Peroxide	135-143	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
18444659-4	2008	We further found that a metabolite of CQA, caffeic acid (CA), but not quinic acid, significantly inhibited the H(2)O(2)-induced IL-8 secretion and its mRNA expression in the same dose-dependent manner.	Amodiaquine	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
18444659-4	2008	We further found that a metabolite of CQA, caffeic acid (CA), but not quinic acid, significantly inhibited the H(2)O(2)-induced IL-8 secretion and its mRNA expression in the same dose-dependent manner.	caffeic acid	43-55	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
18444659-4	2008	We further found that a metabolite of CQA, caffeic acid (CA), but not quinic acid, significantly inhibited the H(2)O(2)-induced IL-8 secretion and its mRNA expression in the same dose-dependent manner.	Hydrogen Peroxide	111-119	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
18444659-6	2008	Caffeic acid at 2.00 mmol/l was able to absolutely block the H(2)O(2)- or TNF-alpha-induced oversecretion of IL-8 in Caco-2 cells.	caffeic acid	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
18444659-6	2008	Caffeic acid at 2.00 mmol/l was able to absolutely block the H(2)O(2)- or TNF-alpha-induced oversecretion of IL-8 in Caco-2 cells.	Hydrogen Peroxide	61-69	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
18464996-4	2008	Precipitation of adenine was increased by salts (NaCl and NaF) whereas it was prevented by DMSO, in agreement with the involvement of hydrophobic interactions (pi-pi stacking) in the vertical stacking of adenine molecules.	Adenine	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
18292390-9	2008	Finally, human macrophages acquire responsiveness to the CXCR2 ligands (IL-8 and Grobeta), as measured by superoxide anion production, after induction of CXCR2 expression by PPAR-gamma ligands.	Superoxides	106-122	C-X-C motif chemokine ligand 8	Homo sapiens	72-88
18079491-6	2008	beta-tryptase also up-regulated IL-8 mRNA expression, as analyzed by RT-PCR and real-time PCR, which was abolished by the transcription inhibitor actinomycin D.	Dactinomycin	146-159	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
18096868-4	2008	NiSO(4) (200 muM) synergistically enhanced CXCL8, yet antagonized CXCL10 mRNA expression and protein release from HLF in response to MALP-2.	niso	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	43-48
18096868-7	2008	The COX-2 inhibitor, NS-398, attenuated NiSO(4) and MALP-2-induced PGE2 and CXCL8 release and partially reversed the NiSO(4)-dependent inhibition of MALP-2-induced CXCL10 release from HLF.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	21-27	C-X-C motif chemokine ligand 8	Homo sapiens	76-81
18096868-7	2008	The COX-2 inhibitor, NS-398, attenuated NiSO(4) and MALP-2-induced PGE2 and CXCL8 release and partially reversed the NiSO(4)-dependent inhibition of MALP-2-induced CXCL10 release from HLF.	niso	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	76-81
18397832-2	2008	We found for the first time that the secretion of interleukin-8 (IL-8) in intestinal epithelial cells stimulated by hydrogen peroxide or TNF-alpha was suppressed in the presence of carnosine (beta-Ala-His), a dietary dipeptide.	Hydrogen Peroxide	116-133	C-X-C motif chemokine ligand 8	Homo sapiens	50-63
18325031-0	2008	Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappaB p65-associated histone acetyltransferase activity.	montelukast	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	59-72
18325031-3	2008	METHODS: We examined the inhibitory effects of montelukast on TNF-alpha-induced IL-8 production in PMA-differentiated U-937 cells.	montelukast	47-58	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
18325031-10	2008	Montelukast induced a concentration-dependent inhibition of TNF-alpha-induced IL-8 release and mRNA expression that reached a plateau at 0.1 microm without affecting cell viability.	montelukast	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
18325031-12	2008	CONCLUSION: Montelukast inhibits TNF-alpha-stimulated IL-8 expression through changes in NF-kappaB p65-associated HAT activity.	montelukast	12-23	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
18358739-12	2008	The effects of acute CS exposure appear to encompass both up-regulation of chemotaxis mechanisms through IL-8, but also down-regulation of innate immunity.	Cesium	21-23	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
18397832-4	2008	The inhibitory effect of carnosine on the IL-8 secretion differed from that of other histidine-containing dipeptides like Gly-His, Ala-His, and anserine (beta-Ala-1-methyl-His), which inhibited both the hydrogen peroxide-induced secretion and mRNA expression of IL-8.	beta-ala-1-methyl-his	154-175	C-X-C motif chemokine ligand 8	Homo sapiens	262-266
18397832-2	2008	We found for the first time that the secretion of interleukin-8 (IL-8) in intestinal epithelial cells stimulated by hydrogen peroxide or TNF-alpha was suppressed in the presence of carnosine (beta-Ala-His), a dietary dipeptide.	Hydrogen Peroxide	116-133	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
18397832-2	2008	We found for the first time that the secretion of interleukin-8 (IL-8) in intestinal epithelial cells stimulated by hydrogen peroxide or TNF-alpha was suppressed in the presence of carnosine (beta-Ala-His), a dietary dipeptide.	2-(3-azaniumylpropanoylamino)-3-(1H-imidazol-5-yl)propanoate	192-204	C-X-C motif chemokine ligand 8	Homo sapiens	50-63
18397832-2	2008	We found for the first time that the secretion of interleukin-8 (IL-8) in intestinal epithelial cells stimulated by hydrogen peroxide or TNF-alpha was suppressed in the presence of carnosine (beta-Ala-His), a dietary dipeptide.	2-(3-azaniumylpropanoylamino)-3-(1H-imidazol-5-yl)propanoate	192-204	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
18397832-2	2008	We found for the first time that the secretion of interleukin-8 (IL-8) in intestinal epithelial cells stimulated by hydrogen peroxide or TNF-alpha was suppressed in the presence of carnosine (beta-Ala-His), a dietary dipeptide.	Dipeptides	217-226	C-X-C motif chemokine ligand 8	Homo sapiens	50-63
18397832-2	2008	We found for the first time that the secretion of interleukin-8 (IL-8) in intestinal epithelial cells stimulated by hydrogen peroxide or TNF-alpha was suppressed in the presence of carnosine (beta-Ala-His), a dietary dipeptide.	Dipeptides	217-226	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
19288836-1	2008	This study sought to evaluate the microhardness of enamel submitted to 10% carbamide peroxide treatment and different methods of remineralization involving sodium fluoride (NaF).	Sodium Fluoride	156-171	C-X-C motif chemokine ligand 8	Homo sapiens	173-176
17669408-9	2008	Treatment of FTEC with TLR3 agonist poly(I:C) resulted in increased expression of interleukin-8, tumor-necrosis factor alpha, human beta-defensin 2, interferon beta, and interferon stimulated genes myxovirus resistance gene 1, 2",5"-oligoadenylate synthetase, and protein kinase R. Additionally, FTEC exposed to poly(I:C) also resulted in the induction of TLR2, TLR3, and TLR7.	poly	36-40	C-X-C motif chemokine ligand 8	Homo sapiens	82-124
17669408-9	2008	Treatment of FTEC with TLR3 agonist poly(I:C) resulted in increased expression of interleukin-8, tumor-necrosis factor alpha, human beta-defensin 2, interferon beta, and interferon stimulated genes myxovirus resistance gene 1, 2",5"-oligoadenylate synthetase, and protein kinase R. Additionally, FTEC exposed to poly(I:C) also resulted in the induction of TLR2, TLR3, and TLR7.	Carbon	16-17	C-X-C motif chemokine ligand 8	Homo sapiens	82-124
19288836-5	2008	Based on these results, NaF therapies are recommended during carbamide peroxide bleaching treatments.	Carbamide Peroxide	61-79	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
18715885-3	2008	The time courses for silica-induced release of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-8 both from co-cultures and monocyte mono-cultures showed an early peak at 5-10 h, almost no response at 20 h, and a strong increase at 43 h. At 43 h, co-cultures also showed strongly increased IL-6 levels.	Silicon Dioxide	21-27	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
18715885-4	2008	Steady-state levels of mRNA roughly exhibited the same pattern of early up-regulation and reduced levels at 20 h. Compared with monocyte mono-cultures, silica induced a strong release of IL-1beta, IL-6, and IL-8, but not of TNF-alpha, after 43 h in co-cultures, whereas at 5 and 10 h a significant difference was only observed for the silica-induced IL-8 response.	Silicon Dioxide	152-158	C-X-C motif chemokine ligand 8	Homo sapiens	207-211
18715885-4	2008	Steady-state levels of mRNA roughly exhibited the same pattern of early up-regulation and reduced levels at 20 h. Compared with monocyte mono-cultures, silica induced a strong release of IL-1beta, IL-6, and IL-8, but not of TNF-alpha, after 43 h in co-cultures, whereas at 5 and 10 h a significant difference was only observed for the silica-induced IL-8 response.	Silicon Dioxide	152-158	C-X-C motif chemokine ligand 8	Homo sapiens	350-354
18080321-3	2008	Our experiments showed that protein production and mRNA expressions of MMP-1, MMP-3, MMP-13, IL-8, MCP-1, and RANTES were downregulated by treatment with glucosamine in HPSFs.	Glucosamine	154-165	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
18464055-9	2008	Sources of fine PM and their relative contributions varied across the sampling sites and a strong linear association was observed between IL-8 and secondary sulfate from coal combustion (r(2) = .79).	Sulfates	157-164	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
18464055-10	2008	Ultrafine vanadium, lead, copper, and sulfate were also associated with increases in IL-8.	ultrafine vanadium	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
18464055-10	2008	Ultrafine vanadium, lead, copper, and sulfate were also associated with increases in IL-8.	Copper	26-32	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
18464055-10	2008	Ultrafine vanadium, lead, copper, and sulfate were also associated with increases in IL-8.	Sulfates	38-45	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
17729256-8	2008	The amounts of interleukin-6 and interleukin-8 proinflammatory cytokines released from human blood leukocytes exposed to the polyurethane scaffolds in vitro were comparable and/or lower than the amount of the cytokines released by leukocytes exposed to the culture-grade polystyrene control.	Polyurethanes	125-137	C-X-C motif chemokine ligand 8	Homo sapiens	33-46
17966119-9	2008	P was the most effective inhibitor of IL-8 release; IL-8 was significantly decreased after exposure to un, tri, tetra and penta but significantly increased after JP-8 exposure compared with controls.	Phosphorus	0-1	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
18080321-6	2008	The results suggest that the inhibition of MMP-1, -3, and -13 expressions as well as IL-8, MCP-1, and RANTES productions by GLN might mediate suppression of NF-kappaB signal pathways, and HPSFs seem to have a potential functions as an alternative source of MMPs and chemokines for inducing the degradation of cartilage in OA.	Glucosamine	124-127	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
18544909-8	2008	Inhibition of extracellular signal-regulated kinase (ERK), one of the MAPK pathways, suppressed the IL-8 production induced by both 2,4-dinitrochlorobenzene (DNCB) and nickel sulfate (NiSO(4)), and inhibition of p38 MAPK, a second MAPK pathway, significantly suppressed IL-8 production induced by only DNCB.	Dinitrochlorobenzene	132-156	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
18544909-8	2008	Inhibition of extracellular signal-regulated kinase (ERK), one of the MAPK pathways, suppressed the IL-8 production induced by both 2,4-dinitrochlorobenzene (DNCB) and nickel sulfate (NiSO(4)), and inhibition of p38 MAPK, a second MAPK pathway, significantly suppressed IL-8 production induced by only DNCB.	Dinitrochlorobenzene	158-162	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
18007587-5	2008	Moreover, downregulation of Hsp27 increased the release of the pro-inflammatory cytokine IL-8 from TNF-alpha-stimulated and UV-irradiated keratinocytes, and this increase was inhibited by pretreatment with the NF-kappaB inhibitor BAY11-7082.	3-(4-methylphenylsulfonyl)-2-propenenitrile	230-240	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
18034171-4	2008	9(S)-HODE evoked intracellular calcium mobilization and secretion of cytokines, including IL-6, IL-8, and GM-CSF in NHEK cells.	9(S)-HODE	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
18353383-7	2008	Urine interleukin-8 was negatively associated with urothelial heparin-binding epidermal growth factor-like growth factor staining (r = -0.34; 95% CI -0.55, -0.12; p = 0.002) and positively associated with lamina propria mast cell count (r = 0.29; 95% CI 0.06, 0.52; p = 0.01).	Heparin	62-69	C-X-C motif chemokine ligand 8	Homo sapiens	6-19
18544909-8	2008	Inhibition of extracellular signal-regulated kinase (ERK), one of the MAPK pathways, suppressed the IL-8 production induced by both 2,4-dinitrochlorobenzene (DNCB) and nickel sulfate (NiSO(4)), and inhibition of p38 MAPK, a second MAPK pathway, significantly suppressed IL-8 production induced by only DNCB.	Dinitrochlorobenzene	158-162	C-X-C motif chemokine ligand 8	Homo sapiens	270-274
18442745-0	2008	Involvement of mitogen-activated protein kinases and nuclear factor-kappa B activation in nitric oxide-induced interleukin-8 expression in human pulp cells.	Nitric Oxide	90-102	C-X-C motif chemokine ligand 8	Homo sapiens	111-124
18544909-8	2008	Inhibition of extracellular signal-regulated kinase (ERK), one of the MAPK pathways, suppressed the IL-8 production induced by both 2,4-dinitrochlorobenzene (DNCB) and nickel sulfate (NiSO(4)), and inhibition of p38 MAPK, a second MAPK pathway, significantly suppressed IL-8 production induced by only DNCB.	nickel sulfate	168-182	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
18544909-8	2008	Inhibition of extracellular signal-regulated kinase (ERK), one of the MAPK pathways, suppressed the IL-8 production induced by both 2,4-dinitrochlorobenzene (DNCB) and nickel sulfate (NiSO(4)), and inhibition of p38 MAPK, a second MAPK pathway, significantly suppressed IL-8 production induced by only DNCB.	niso	184-188	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
18544909-8	2008	Inhibition of extracellular signal-regulated kinase (ERK), one of the MAPK pathways, suppressed the IL-8 production induced by both 2,4-dinitrochlorobenzene (DNCB) and nickel sulfate (NiSO(4)), and inhibition of p38 MAPK, a second MAPK pathway, significantly suppressed IL-8 production induced by only DNCB.	niso	184-188	C-X-C motif chemokine ligand 8	Homo sapiens	270-274
18544909-8	2008	Inhibition of extracellular signal-regulated kinase (ERK), one of the MAPK pathways, suppressed the IL-8 production induced by both 2,4-dinitrochlorobenzene (DNCB) and nickel sulfate (NiSO(4)), and inhibition of p38 MAPK, a second MAPK pathway, significantly suppressed IL-8 production induced by only DNCB.	Dinitrochlorobenzene	302-306	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
18544909-9	2008	Additionally, neutralization of TNF-alpha activity suppressed IL-8 production in THP-1 cells exposed to DNCB and NiSO(4).	Dinitrochlorobenzene	104-108	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
18544909-9	2008	Additionally, neutralization of TNF-alpha activity suppressed IL-8 production in THP-1 cells exposed to DNCB and NiSO(4).	niso	113-117	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
18544909-10	2008	In conclusion, IL-8 production was predominantly induced in THP-1 cells following allergen stimulation, and MAPK pathways and TNF-alpha were involved in the IL-8 production induced by DNCB and NiSO(4).	Dinitrochlorobenzene	184-188	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
18544909-10	2008	In conclusion, IL-8 production was predominantly induced in THP-1 cells following allergen stimulation, and MAPK pathways and TNF-alpha were involved in the IL-8 production induced by DNCB and NiSO(4).	niso	193-197	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
18442745-4	2008	RESULTS: Sodium nitroprusside (SNP), an NO donor, has increased IL-8 secretion and mRNA expression in a dose- and time-dependent manner.	Nitroprusside	9-29	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
18442745-1	2008	OBJECTIVE: This study examined the effect of nitric oxide (NO) on interleukin-8 (IL-8) production and the involvement of mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappaB) signaling pathways in primary cultured human pulp cells.	Nitric Oxide	45-57	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
18390748-5	2008	Furthermore, inhibition of Pyk2 activity in these cells by transduction with the catalytically inactive Pyk2 mutant, transfection with Pyk2-specific small interfering RNA, or treatment with Tyrphostin A9 significantly blocked LPS-induced IL-8 production.	tyrphostin A9	190-203	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
18953964-0	2008	[The mechanism of inhibition by ginkgolide B on interleukin-8 production induced by 4-hydroxynonenal in bronchial epithelial cells].	ginkgolide B	32-44	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
18953964-0	2008	[The mechanism of inhibition by ginkgolide B on interleukin-8 production induced by 4-hydroxynonenal in bronchial epithelial cells].	4-hydroxy-2-nonenal	84-100	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
18953964-1	2008	OBJECTIVE: 4-Hydroxynonenal (4-HNE) can increase the synthesis of interleukin-8 (IL-8) in bronchial epithelium cells (16HBE).	4-hydroxy-2-nonenal	11-27	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
18953964-1	2008	OBJECTIVE: 4-Hydroxynonenal (4-HNE) can increase the synthesis of interleukin-8 (IL-8) in bronchial epithelium cells (16HBE).	4-hydroxy-2-nonenal	11-27	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
18953964-1	2008	OBJECTIVE: 4-Hydroxynonenal (4-HNE) can increase the synthesis of interleukin-8 (IL-8) in bronchial epithelium cells (16HBE).	4-hydroxy-2-nonenal	29-34	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
18953964-1	2008	OBJECTIVE: 4-Hydroxynonenal (4-HNE) can increase the synthesis of interleukin-8 (IL-8) in bronchial epithelium cells (16HBE).	4-hydroxy-2-nonenal	29-34	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
18953964-2	2008	This study was to explore the role of ginkgolide B in inhibiting the synthesis of IL-8 induced by 4-HNE in 16HBE.	ginkgolide B	38-50	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
18953964-2	2008	This study was to explore the role of ginkgolide B in inhibiting the synthesis of IL-8 induced by 4-HNE in 16HBE.	4-hydroxy-2-nonenal	98-103	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
18953964-2	2008	This study was to explore the role of ginkgolide B in inhibiting the synthesis of IL-8 induced by 4-HNE in 16HBE.	16hbe	107-112	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
18953964-8	2008	RESULTS: The level of IL-8 in 10 micromol/L 4-HNE, 100 micromol/L ginkgolide B + 10 micromol/L 4-HNE, the control groups after 4-HNE stimulating for 4 h were (98.3 +/- 4.2), (88.2 +/- 5.3), (65.3 +/- 6.	4-hydroxy-2-nonenal	44-49	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
18953964-12	2008	The expression of IL-8 and the AP-1 combining activity in groups of pre-incubated with PD98059 2 hours before 4-HNE stimulation were lower than that without PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	87-94	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
18953964-12	2008	The expression of IL-8 and the AP-1 combining activity in groups of pre-incubated with PD98059 2 hours before 4-HNE stimulation were lower than that without PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	157-164	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
18953964-15	2008	Ginkgolide B inhibited synthesis of IL-8 by blocking ERK1-AP1 transduction pathways.	ginkgolide B	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
18646527-0	2008	[Effect of Zn2+ on level of IL-8 and TNF-alpha mRNA and protein expressed of human II alveolar epithelial cells].	Zinc	11-15	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
18646527-1	2008	OBJECTIVE: To study the effect of Zn2+ on levels of the cytokines IL-8 and TNF-alpha mRNA expression of human II alveolar epithelial cell.	Zinc	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
18646527-3	2008	RESULTS: Incubation of A549 cells with Zn2+ for 3 h and 24h could stimulate the accumulations of IL-8 and TNF-alpha mRNA and protein of A549 cells in a concentration-dependent manner.	Zinc	39-43	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
18646527-4	2008	CONCLUSION: The production of IL-8 and TNF-alpha mRNA and protein from A549 cells stimulated by Zn2+ could be important source of cytokines in respiratory damage induced by Zn2+.	Zinc	96-100	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
18646527-4	2008	CONCLUSION: The production of IL-8 and TNF-alpha mRNA and protein from A549 cells stimulated by Zn2+ could be important source of cytokines in respiratory damage induced by Zn2+.	Zinc	173-177	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
18252714-0	2008	Toll-like receptor 4 mediates induction of the Bcl10-NFkappaB-interleukin-8 inflammatory pathway by carrageenan in human intestinal epithelial cells.	Carrageenan	100-111	C-X-C motif chemokine ligand 8	Homo sapiens	62-75
18252714-1	2008	The sulfated polysaccharide carrageenan (CGN) induces activation of NFkappaB and interleukin 8 (IL-8) in human colonic epithelial cells through a pathway of innate immunity mediated by Bcl10 (B-cell CLL/lymphoma 10).	Polysaccharides	13-27	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
18252714-1	2008	The sulfated polysaccharide carrageenan (CGN) induces activation of NFkappaB and interleukin 8 (IL-8) in human colonic epithelial cells through a pathway of innate immunity mediated by Bcl10 (B-cell CLL/lymphoma 10).	Polysaccharides	13-27	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
18252714-1	2008	The sulfated polysaccharide carrageenan (CGN) induces activation of NFkappaB and interleukin 8 (IL-8) in human colonic epithelial cells through a pathway of innate immunity mediated by Bcl10 (B-cell CLL/lymphoma 10).	Carrageenan	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
18252714-1	2008	The sulfated polysaccharide carrageenan (CGN) induces activation of NFkappaB and interleukin 8 (IL-8) in human colonic epithelial cells through a pathway of innate immunity mediated by Bcl10 (B-cell CLL/lymphoma 10).	Carrageenan	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
18252714-1	2008	The sulfated polysaccharide carrageenan (CGN) induces activation of NFkappaB and interleukin 8 (IL-8) in human colonic epithelial cells through a pathway of innate immunity mediated by Bcl10 (B-cell CLL/lymphoma 10).	Carrageenan	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
18252714-1	2008	The sulfated polysaccharide carrageenan (CGN) induces activation of NFkappaB and interleukin 8 (IL-8) in human colonic epithelial cells through a pathway of innate immunity mediated by Bcl10 (B-cell CLL/lymphoma 10).	Carrageenan	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
18276593-8	2008	The EGFR inhibitor AG1478, completely blocked IL-8 and ICAM-1 expression to basal levels, as did the specific Erk1/2 inhibitor U0126.	RTKI cpd	19-25	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
18400717-8	2008	IL-8 production was significantly decreased by troglitazone, ALA, DHA, EPA, and GLA.	Troglitazone	47-59	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
18276593-9	2008	The p38 mitogen-activated protein kinase inhibitor SB203580 blocked IL-8 secretion but not ICAM-1 expression, whereas the PI3K inhibitor wortmannin was ineffective in both responses.	SB 203580	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
18400717-8	2008	IL-8 production was significantly decreased by troglitazone, ALA, DHA, EPA, and GLA.	alpha-Linolenic Acid	61-64	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
18400717-12	2008	Addition of GW9662 reversed the effect of troglitazone and PUFAs at 0.1 mumol/L on IL-8 production and decreased the expression of PPARgamma.	2-chloro-5-nitrobenzanilide	12-18	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
18400717-8	2008	IL-8 production was significantly decreased by troglitazone, ALA, DHA, EPA, and GLA.	Docosahexaenoic Acids	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
18400717-12	2008	Addition of GW9662 reversed the effect of troglitazone and PUFAs at 0.1 mumol/L on IL-8 production and decreased the expression of PPARgamma.	Troglitazone	42-54	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
18400717-8	2008	IL-8 production was significantly decreased by troglitazone, ALA, DHA, EPA, and GLA.	Eicosapentaenoic Acid	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
18400717-12	2008	Addition of GW9662 reversed the effect of troglitazone and PUFAs at 0.1 mumol/L on IL-8 production and decreased the expression of PPARgamma.	Fatty Acids, Unsaturated	59-64	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
18400717-8	2008	IL-8 production was significantly decreased by troglitazone, ALA, DHA, EPA, and GLA.	gamma-Linolenic Acid	80-83	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
18299991-3	2008	In cultured human aortic endothelial cells (HAEC), arterial shear stress of 10 dyne/cm(2) blocked by &gt;80% the induction by 5 ng/mL TNFalpha of interleukin-8 (IL-8) and IL-6 secretion (50 and 90% reduction, respectively, in the presence of nitric oxide synthase antagonism with 200 microM nitro-L-arginine methylester, L-NAME).	Nitroarginine	291-307	C-X-C motif chemokine ligand 8	Homo sapiens	146-159
18299991-3	2008	In cultured human aortic endothelial cells (HAEC), arterial shear stress of 10 dyne/cm(2) blocked by &gt;80% the induction by 5 ng/mL TNFalpha of interleukin-8 (IL-8) and IL-6 secretion (50 and 90% reduction, respectively, in the presence of nitric oxide synthase antagonism with 200 microM nitro-L-arginine methylester, L-NAME).	NG-Nitroarginine Methyl Ester	321-327	C-X-C motif chemokine ligand 8	Homo sapiens	146-159
18234309-6	2008	RESULTS: Human embryonic kidney 293 transfectants mimicking this heterozygous mutation produced less IL-8 when stimulated with lipoteichoic acid (LTA), heat-inactivated Staphylococcus aureus or triacylated lipopeptides requiring the TLR-2/1 heterodimer.	lipoteichoic acid	127-144	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
18207234-3	2008	Removal of inflammatory cytokines TNF, IL-6, IL-1beta and IL-8 was assessed by filtering cytokine spiked human plasma through the walls of the carbon modules under pressure.	Carbon	143-149	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
18307536-7	2008	IL-8 expression was inducible by hypoxia mimicking reagent cobalt chloride.	cobaltous chloride	59-74	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
18094008-7	2008	EGF-CM contained significant neutrophil chemotactic activity involving granulocyte-macrophage colony-stimulating factor and interleukin-8 that was potentiated by leukotriene B(4).	Leukotriene B4	162-175	C-X-C motif chemokine ligand 8	Homo sapiens	124-137
18234317-9	2008	Malondialdehyde levels were inversely associated with forced vital capacity and FEV(1) and positively associated with IL-8 levels in nasal lavage.	Malondialdehyde	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
18199004-3	2008	LTC 4 affects the GSH/GSSG ratio by activating signals to increase interleukin-8 (IL-8) production.	Glutathione	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
18199004-3	2008	LTC 4 affects the GSH/GSSG ratio by activating signals to increase interleukin-8 (IL-8) production.	Glutathione	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
18199004-3	2008	LTC 4 affects the GSH/GSSG ratio by activating signals to increase interleukin-8 (IL-8) production.	Glutathione Disulfide	22-26	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
18199004-3	2008	LTC 4 affects the GSH/GSSG ratio by activating signals to increase interleukin-8 (IL-8) production.	Glutathione Disulfide	22-26	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
18199004-4	2008	Pretreatment with a reducing agent, glutathione monochrome ester (GSH-OEt), and with a leukotriene receptor antagonist, montelukast, significantly suppressed LTC(4)-induced time-dependent changes in the intracellular redox state, and also suppressed upregulation of IL-8 production by suppressing NF-kappaB activation.	glutathione monochrome ester	36-64	C-X-C motif chemokine ligand 8	Homo sapiens	266-270
18199004-4	2008	Pretreatment with a reducing agent, glutathione monochrome ester (GSH-OEt), and with a leukotriene receptor antagonist, montelukast, significantly suppressed LTC(4)-induced time-dependent changes in the intracellular redox state, and also suppressed upregulation of IL-8 production by suppressing NF-kappaB activation.	S-ethyl glutathione	66-73	C-X-C motif chemokine ligand 8	Homo sapiens	266-270
18199004-4	2008	Pretreatment with a reducing agent, glutathione monochrome ester (GSH-OEt), and with a leukotriene receptor antagonist, montelukast, significantly suppressed LTC(4)-induced time-dependent changes in the intracellular redox state, and also suppressed upregulation of IL-8 production by suppressing NF-kappaB activation.	montelukast	120-131	C-X-C motif chemokine ligand 8	Homo sapiens	266-270
18212111-1	2008	The production of interleukin-8 induced by the activation of protease-activated receptor 2 and its synergism with interleukin-1beta were modulated by 14-membered-ring macrolides, namely, roxithromycin, erythromycin, and clarithromycin, in cultured normal human epidermal keratinocytes.	Roxithromycin	187-200	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
18212111-1	2008	The production of interleukin-8 induced by the activation of protease-activated receptor 2 and its synergism with interleukin-1beta were modulated by 14-membered-ring macrolides, namely, roxithromycin, erythromycin, and clarithromycin, in cultured normal human epidermal keratinocytes.	Erythromycin	202-214	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
18212111-1	2008	The production of interleukin-8 induced by the activation of protease-activated receptor 2 and its synergism with interleukin-1beta were modulated by 14-membered-ring macrolides, namely, roxithromycin, erythromycin, and clarithromycin, in cultured normal human epidermal keratinocytes.	Clarithromycin	220-234	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
18212111-2	2008	Those macrolides may attenuate the protease-activated receptor 2-interleukin-8 axis and thereby modulate proinflammatory responses in the skin.	Macrolides	6-16	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
18005471-8	2008	The interleukins were significantly higher at some perioperative time points in the fentanyl group compared to the remifentanil group (tumour necrosis factor: T5: 3.57 vs. 2.37; IL-6: T5: 4.62 vs. 3.73; and IL-8: T5: 4.43 vs. 2.65 and T6: 2.61 vs. 1.13).	Fentanyl	84-92	C-X-C motif chemokine ligand 8	Homo sapiens	207-211
18395088-11	2008	IL-8 expression was dependent on COX-2-mediated prostaglandin E(2) synthesis.	Dinoprostone	48-66	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
18395088-12	2008	In the presence of an NF-kappaB inhibitor MG132, IL-8 transcription was inhibited, but not that of COX-2.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	42-47	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
18377624-1	2008	We developed a method for the quantitative determination of sodium fluoride (NaF), sodium monofluorophosphate (SMFP) and amine fluoride (AmF) in toothpastes on the Belgian market.	Sodium Fluoride	60-75	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
18234309-6	2008	RESULTS: Human embryonic kidney 293 transfectants mimicking this heterozygous mutation produced less IL-8 when stimulated with lipoteichoic acid (LTA), heat-inactivated Staphylococcus aureus or triacylated lipopeptides requiring the TLR-2/1 heterodimer.	lipoteichoic acid	146-149	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
18415826-0	2008	Effect of budesonide and formoterol on IL-6 and IL-8 release from primary bronchial epithelial cells.	Formoterol Fumarate	25-35	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
18415826-5	2008	Budesonide attenuated the IL-6 and IL-8 release, an inhibiting effect that was sustained, but not reinforced, by formoterol.	Budesonide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
18234309-6	2008	RESULTS: Human embryonic kidney 293 transfectants mimicking this heterozygous mutation produced less IL-8 when stimulated with lipoteichoic acid (LTA), heat-inactivated Staphylococcus aureus or triacylated lipopeptides requiring the TLR-2/1 heterodimer.	Lipopeptides	206-218	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
18297698-2	2008	This study was undertaken to determine whether SK, either alone or in combination with quercitin (QT) is able to modulate the release of IL-6 and IL-8 from peripheral blood mononuclear cells (PBMCs).	Quercetin	87-96	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
18354227-0	2008	Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation.	Cyclic AMP	162-166	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
18354227-4	2008	Furthermore, an intracellular Ca(2+) chelator (BAPTA-AM), which inhibited VacA-activated p38 MAPK, caused a dose-dependent reduction in VacA-induced IL-8 secretion by U937 cells, implying a role for intracellular Ca(2+) in mediating activation of MAPK and the canonical NF-kappaB pathway.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	47-55	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
18297698-2	2008	This study was undertaken to determine whether SK, either alone or in combination with quercitin (QT) is able to modulate the release of IL-6 and IL-8 from peripheral blood mononuclear cells (PBMCs).	Quercetin	98-100	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
18297698-5	2008	On the contrary, incubation with SK and QT at both concentrations (10 and 100 nM) produced a significant increase in the release of IL-8 as compared to other groups (4.19 +/- 0.82, SK-QT 10 nM; 3.83 +/- 1.17 SK-QT 100 nM, P &lt; 0.05 vs. baseline 1.00 +/- 0.10, Tamiflu 100 nM 1.35 +/- 0.16, SK 10 nM 1.68 +/- 0.15 and SK 100 nM 1.80 +/- 0.48).	Oseltamivir	262-269	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
18349372-3	2008	In contrast, arginine-specific gingipain 2 (RgpB) increased IL-8 production.	Arginine	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
18234802-0	2008	Epstein-Barr virus lytic transactivator Zta enhances chemotactic activity through induction of interleukin-8 in nasopharyngeal carcinoma cells.	zta	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	95-108
18234802-6	2008	Further studies showed that the EBV lytic transactivator Zta is a potent inducer of IL-8 in NPC cells, augmenting secreted and intracellular IL-8 proteins, as well as IL-8 RNA.	zta	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
18234802-6	2008	Further studies showed that the EBV lytic transactivator Zta is a potent inducer of IL-8 in NPC cells, augmenting secreted and intracellular IL-8 proteins, as well as IL-8 RNA.	zta	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
18234802-6	2008	Further studies showed that the EBV lytic transactivator Zta is a potent inducer of IL-8 in NPC cells, augmenting secreted and intracellular IL-8 proteins, as well as IL-8 RNA.	zta	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
18234802-7	2008	Zta upregulates Egr-1, a cellular transcription factor that has been involved in upregulation of IL-8, but the Zta-induced IL-8 expression is independent of Egr-1.	zta	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
18234802-7	2008	Zta upregulates Egr-1, a cellular transcription factor that has been involved in upregulation of IL-8, but the Zta-induced IL-8 expression is independent of Egr-1.	zta	111-114	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
18234802-8	2008	The ability of Zta to transactivate the IL-8 promoter is important for the induction of IL-8, and we have identified two Zta-responsive elements in the promoter.	zta	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
18234802-8	2008	The ability of Zta to transactivate the IL-8 promoter is important for the induction of IL-8, and we have identified two Zta-responsive elements in the promoter.	zta	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
18234802-8	2008	The ability of Zta to transactivate the IL-8 promoter is important for the induction of IL-8, and we have identified two Zta-responsive elements in the promoter.	zta	121-124	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
18234802-9	2008	Zta can bind to these two elements in vitro and can also be recruited to the IL-8 promoter in vivo.	zta	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
18234802-10	2008	DNA-binding-defective Zta mutants can neither activate the IL-8 promoter nor induce IL-8 production.	zta	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
18234802-10	2008	DNA-binding-defective Zta mutants can neither activate the IL-8 promoter nor induce IL-8 production.	zta	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
18234802-11	2008	In addition, Zta-expressing NPC cells exert enhanced chemotactic activity that is mainly mediated by IL-8.	zta	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
18380907-9	2008	CONCLUSION: Gram-positive or gram-negative bacteria activate human ASMC to release CXCL-8.	asmc	67-71	C-X-C motif chemokine ligand 8	Homo sapiens	83-89
18206243-0	2008	IL-8 production and AP-1 transactivation induced by UVA in human keratinocytes: roles of D-alpha-tocopherol.	alpha-Tocopherol	89-107	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
18206243-2	2008	Here, we investigated the role of D-alpha-tocopherol in the regulation of IL-8 production and AP-1 binding activity in UVA-irradiated human keratinocytes.	alpha-Tocopherol	34-52	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
18206243-7	2008	These results demonstrated that D-alpha-tocopherol may be able to prevent the IL-8 upregulation and the increase in AP-1 activation induced by UVA irradiation through down-modulating cellular oxidative stress.	alpha-Tocopherol	32-50	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
17986175-9	2008	Viable and motile spermatozoa attached to PMN without being phagocytosed within 60 min (45 +/- 3%), whereas binding to sodium fluoride (NaF)-immobilized spermatozoa was reduced to 20 +/- 2%.	Sodium Fluoride	119-134	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
18380907-12	2008	Our findings that ASMC can respond directly to gram-negative and gram-positive bacteria by releasing the neutrophil selective chemokine, CXCL-8, is consistent with what we know about the role of neutrophil recruitment in bacterial infections in the lung.	asmc	18-22	C-X-C motif chemokine ligand 8	Homo sapiens	137-143
19124359-9	2008	CONCLUSION: In ex-smokers with severe COPD, a measure of local pulmonary inflammation, FENO, may be more closely associated with FEV1 responses to four weeks of ICS than are standard markers of systemic inflammation, serum CRP, IL-6, and IL-8.	flubendiamide	87-91	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
17724435-10	2008	SB203580 also prevented the CytoMix-induced permeability increase and reduced NO, IL-6, and IL-8 levels.	SB 203580	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
18343055-5	2008	Dose-dependent increases in NF-kappaB activity and IL-8 secretion were observed, reaching 1.4- and 7.6-fold, respectively using DON at 10 microg/ml.	deoxynivalenol	128-131	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
18343055-9	2008	These data show that DON induces NF-kappaB activation and IL-8 secretion dose-dependently in Caco-2 cells, and this effect was accentuated upon pro-inflammatory stimulation, suggesting DON exposure could cause or exacerbate intestinal inflammation.	deoxynivalenol	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
18343055-9	2008	These data show that DON induces NF-kappaB activation and IL-8 secretion dose-dependently in Caco-2 cells, and this effect was accentuated upon pro-inflammatory stimulation, suggesting DON exposure could cause or exacerbate intestinal inflammation.	deoxynivalenol	185-188	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
18308354-5	2008	Deoxynivalenol was the only mycotoxin able to directly increase IL-8 secretion (10- to 15-fold increase).	deoxynivalenol	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
18308354-7	2008	We found that deoxynivalenol, ochratoxin A and patulin all potentiated the effect of IL-1beta on IL-8 secretion (ranging from 35% to 138% increase) and increased the transepithelial passage of commensal bacteria (ranging from 12- to 1544-fold increase).	deoxynivalenol	14-28	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
18308354-7	2008	We found that deoxynivalenol, ochratoxin A and patulin all potentiated the effect of IL-1beta on IL-8 secretion (ranging from 35% to 138% increase) and increased the transepithelial passage of commensal bacteria (ranging from 12- to 1544-fold increase).	ochratoxin A	30-42	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
18242599-0	2008	Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism.	Acetylcholine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
18664200-3	2008	The modulation of cetirizine on the production of interferon (IFN)-gamma, interleukin (IL)-1beta, IL-6 and IL-8 in HaCaT cells and fibroblasts was measured by ELISA.	Cetirizine	18-28	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
18664200-6	2008	Cetirizine 1-100 micromol x L(-1) inhibited SP-induced IL-1beta and IL-8 production in HaCaT cells and fibroblasts, while had no effect on the production of IFN-gamma in both cells.	cetirizine 1	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
18664200-8	2008	These findings suggest that cetirizine may be involved in the treatment of SP-induced skin inflammation by inhibiting the expression of substance P receptor and regulation the production of IL-1beta and IL-8 in epidermal keratinocyte and dermal fibroblasts.	Cetirizine	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
18191106-12	2008	Analysis of the proangiogenic factors IL-8 and VEGF showed significant reduction in IL-8 production by moxifloxacin and ciprofloxacin up to 48% and in VEGF secretion from the cells.	Moxifloxacin	103-115	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
18191106-12	2008	Analysis of the proangiogenic factors IL-8 and VEGF showed significant reduction in IL-8 production by moxifloxacin and ciprofloxacin up to 48% and in VEGF secretion from the cells.	Moxifloxacin	103-115	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
18191106-12	2008	Analysis of the proangiogenic factors IL-8 and VEGF showed significant reduction in IL-8 production by moxifloxacin and ciprofloxacin up to 48% and in VEGF secretion from the cells.	Ciprofloxacin	120-133	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
18242599-4	2008	Additionally, we tested the IL-8-mediated neutrophil chemotactic activity of 16HBE supernatants stimulated with acetylcholine in the presence or absence of tiotropium.	16hbe	77-82	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
18242599-4	2008	Additionally, we tested the IL-8-mediated neutrophil chemotactic activity of 16HBE supernatants stimulated with acetylcholine in the presence or absence of tiotropium.	Acetylcholine	112-125	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
18242599-6	2008	Acetylcholine (10 microM) significantly stimulated ERK1/2 and NFkB activation as well as IL-8 release in 16HBE cells when compared to basal values.	Acetylcholine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
18242599-8	2008	Additionally, acetylcholine-mediated IL-8 release from 16HBE cells significantly increased chemotaxis toward neutrophils and this effect was blocked by tiotropium.	Acetylcholine	14-27	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
18242599-8	2008	Additionally, acetylcholine-mediated IL-8 release from 16HBE cells significantly increased chemotaxis toward neutrophils and this effect was blocked by tiotropium.	Tiotropium Bromide	152-162	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
18242599-9	2008	In conclusion, acetylcholine activates the release of IL-8 from 16HBE involving PKC, ERK1/2 and NFkB pathways via muscarinic receptors, suggesting that it is likely to contribute to IL-8 related neutrophilic inflammatory disorders in the airway.	Acetylcholine	15-28	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
18242599-9	2008	In conclusion, acetylcholine activates the release of IL-8 from 16HBE involving PKC, ERK1/2 and NFkB pathways via muscarinic receptors, suggesting that it is likely to contribute to IL-8 related neutrophilic inflammatory disorders in the airway.	Acetylcholine	15-28	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
18289803-8	2008	Overall, these data highlight an AhR-dependent regulation of IL-8 in response to BP that likely contributes to the airway inflammatory effects of this environmental chemical.	Benzo(a)pyrene	81-83	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
18281166-5	2008	Meanwhile, treatment with actinomycin D facilitated the Trp-P-1-induced down-regulation of IL-8 expression in LPS-stimulated THP-1 cells, implying that the inhibition might be due to a decrease in the stability of IL-8 mRNA rather than an attenuation of IL-8 transcription.	Dactinomycin	26-39	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
18281166-0	2008	3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) attenuates LPS-induced IL-8 expression by decreasing mRNA stability in THP-1 cells.	3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole	0-43	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
17915188-1	2008	Using human osteoblastic SaM-1 cells, we investigated the effects of lysophosphatidic acid (LPA) on the production of interleukin (IL)-6 and IL-8, molecules which are capable of stimulating the development of osteoclasts from their haematopoietic precursors, and examined the signal transduction systems involved in their effect on these cells.	lysophosphatidic acid	69-90	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
18281166-5	2008	Meanwhile, treatment with actinomycin D facilitated the Trp-P-1-induced down-regulation of IL-8 expression in LPS-stimulated THP-1 cells, implying that the inhibition might be due to a decrease in the stability of IL-8 mRNA rather than an attenuation of IL-8 transcription.	Dactinomycin	26-39	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
18281166-5	2008	Meanwhile, treatment with actinomycin D facilitated the Trp-P-1-induced down-regulation of IL-8 expression in LPS-stimulated THP-1 cells, implying that the inhibition might be due to a decrease in the stability of IL-8 mRNA rather than an attenuation of IL-8 transcription.	Dactinomycin	26-39	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
18281166-7	2008	Exogenous addition of ionomycin rescued both the IL-8 protein levels and phosphorylation of p38 MAP kinase inhibited by Trp-P-1.	Ionomycin	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
18289803-0	2008	Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation.	Benzo(a)pyrene	57-71	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
18289803-3	2008	In primary human macrophages, BP was shown to induce IL-8 expression at both mRNA and secretion levels in a dose-dependent manner.	Benzo(a)pyrene	30-32	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
18289803-4	2008	Such an up-regulation was likely linked to aryl hydrocarbon receptor (AhR)-activation since BP-mediated IL-8 induction was reduced after AhR expression knock-down through RNA interference.	Benzo(a)pyrene	92-94	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
18289803-5	2008	Moreover, electrophoretic mobility shift assays (EMSAs) and chromatin immunoprecipitation experiments showed BP-triggered binding of AhR to a consensus xenobiotic responsive element (XRE) found in the human IL-8 promoter.	Benzo(a)pyrene	109-111	C-X-C motif chemokine ligand 8	Homo sapiens	207-211
18352197-1	2008	Axially localized NaF dopants are coated onto Al cylindrical wire arrays in order to act as spectroscopic tracers in the stagnated z-pinch plasma.	Aluminum	46-48	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
17915188-1	2008	Using human osteoblastic SaM-1 cells, we investigated the effects of lysophosphatidic acid (LPA) on the production of interleukin (IL)-6 and IL-8, molecules which are capable of stimulating the development of osteoclasts from their haematopoietic precursors, and examined the signal transduction systems involved in their effect on these cells.	lysophosphatidic acid	92-95	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
17915188-4	2008	The expression of IL-6 and IL-8 mRNAs was maximal at 1-3h, and the increase in IL-6 and IL-8 synthesis in response to lysophosphatidic acid (1-10 microM) occurred in a concentration-dependent manner.	lysophosphatidic acid	118-139	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
17915188-4	2008	The expression of IL-6 and IL-8 mRNAs was maximal at 1-3h, and the increase in IL-6 and IL-8 synthesis in response to lysophosphatidic acid (1-10 microM) occurred in a concentration-dependent manner.	lysophosphatidic acid	118-139	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
17915188-7	2008	The pretreatment of SaM-1 cells with U-73122, a phospholipase C (PLC) inhibitor, and 2-APB also inhibited the increase in IL-6 and IL-8 synthesis in response to LPA.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	37-44	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
17915188-7	2008	The pretreatment of SaM-1 cells with U-73122, a phospholipase C (PLC) inhibitor, and 2-APB also inhibited the increase in IL-6 and IL-8 synthesis in response to LPA.	lysophosphatidic acid	161-164	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
17915188-8	2008	These findings suggest that extracellular LPA-induced IL-6 and IL-8 synthesis occurred through Edg-2 (LPA(1) receptor) and the activation of PLC and IP(3)-mediated intracellular calcium release in SaM-1 cells.	lysophosphatidic acid	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
18266269-4	2008	PPG 1200 was the most potent inhibitor tested, shown for TNF, IL-1beta, IL-6, IL-8, IL-10 and TGF-beta induction, and displayed no cytotoxic effects.	ppg 1200	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
18356657-5	2008	Compared with the conventional group, the mini-CPB group had lower levels of IL-8 on postoperative day 1 (8.3 +/- 6.4 vs. 19 +/- 11 pg/mL, p = 0.016) and of neutrophil elastase on postoperative days 1 (127 +/- 52 vs. 240 +/- 100 microg/L, p = 0.013) and 2 (107 +/- 17 vs. 170 +/- 45 micro/L, p = 0.0001).	cpb	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
18226915-5	2008	All chemokines except RANTES were significantly high in PF compared to BL in TB group, whereas IL-8 and MCP-1 showed significant increase only in NTB PF.	ntb pf	146-152	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
17786963-5	2008	The HNP-induced IL-8 production was blocked by the Src tyrosine kinase inhibitor PP2, MEK1/2 inhibitor U0126, and the phosphatidylinositol 3 kinase (PI3K) inhibitor LY294002, but not by the JNK inhibitor SP600125 in both cell types.	pyrazolanthrone	204-212	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
17786963-6	2008	Treatment with the p38 inhibitor SB203580 attenuated the HNP-induced IL-8 production only in monocytes.	SB 203580	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
17786963-5	2008	The HNP-induced IL-8 production was blocked by the Src tyrosine kinase inhibitor PP2, MEK1/2 inhibitor U0126, and the phosphatidylinositol 3 kinase (PI3K) inhibitor LY294002, but not by the JNK inhibitor SP600125 in both cell types.	U 0126	103-108	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
18354287-9	2008	Only initial IL-8 was associated with increased Pao2/Fio2 (P = .013) and with a minimum Pao2/Fio2 &gt;200 (P = .042) during 72 hours.	pao2	48-52	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
17786963-5	2008	The HNP-induced IL-8 production was blocked by the Src tyrosine kinase inhibitor PP2, MEK1/2 inhibitor U0126, and the phosphatidylinositol 3 kinase (PI3K) inhibitor LY294002, but not by the JNK inhibitor SP600125 in both cell types.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
18171700-0	2008	Lysophosphatidic acid up-regulates expression of interleukin-8 and -6 in granulosa-lutein cells through its receptors and nuclear factor-kappaB dependent pathways: implications for angiogenesis of corpus luteum and ovarian hyperstimulation syndrome.	lysophosphatidic acid	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	49-69
18171700-14	2008	LPA induced IL-8 and IL-6 through different pathways.	lysophosphatidic acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
18171700-15	2008	LPA-induced IL-8 and IL-6 increased permeability of human umbilical vein endothelial cell monolayer.	lysophosphatidic acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
18171700-16	2008	CONCLUSIONS: LPA induces IL-8 and IL-6 expressions through LPA receptors and nuclear factor-kappaB dependent pathways in granulosa-lutein cells.	lysophosphatidic acid	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
18171700-18	2008	Large amounts of LPA-induced IL-8 and IL-6 from multiple corpora luteae of stimulated ovaries may be one of the pathophysiological causes of ovarian hyperstimulation syndrome.	lysophosphatidic acid	17-20	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
18354287-9	2008	Only initial IL-8 was associated with increased Pao2/Fio2 (P = .013) and with a minimum Pao2/Fio2 &gt;200 (P = .042) during 72 hours.	fio2	53-57	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
18354287-9	2008	Only initial IL-8 was associated with increased Pao2/Fio2 (P = .013) and with a minimum Pao2/Fio2 &gt;200 (P = .042) during 72 hours.	pao2	88-92	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
18354287-9	2008	Only initial IL-8 was associated with increased Pao2/Fio2 (P = .013) and with a minimum Pao2/Fio2 &gt;200 (P = .042) during 72 hours.	fio2	93-97	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
18344608-2	2008	GL, as well as dexamethasone (DEX) inhibited both tumor necrosis factor (TNF)-alpha- and IL-1beta-induced IL-8 production, mRNA expression, and promoter activity in A549 cells.	Dexamethasone	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
18292514-6	2008	Engagement of 2DL4 was also shown to activate the transcription and translation of a variety of cytokine genes, including TNF-alpha, IFN-gamma, MIP1alpha, MIP1beta, and IL-8.	2dl4	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
18292514-7	2008	Pharmacological inhibitors of JNK, MEK1/2 and p38, blocked IFN-gamma, IL-8, and MIP1alpha production, suggesting that MAPKs are regulating 2DL4-mediated cytokine production in a nonredundant manner.	2dl4	139-143	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
18344608-0	2008	Glycyrrhizin inhibits interleukin-8 production and nuclear factor-kappaB activity in lung epithelial cells, but not through glucocorticoid receptors.	Glycyrrhizic Acid	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	22-35
18344608-2	2008	GL, as well as dexamethasone (DEX) inhibited both tumor necrosis factor (TNF)-alpha- and IL-1beta-induced IL-8 production, mRNA expression, and promoter activity in A549 cells.	Glycyrrhizic Acid	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
18344608-2	2008	GL, as well as dexamethasone (DEX) inhibited both tumor necrosis factor (TNF)-alpha- and IL-1beta-induced IL-8 production, mRNA expression, and promoter activity in A549 cells.	Dexamethasone	15-28	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
18071189-5	2008	Ox-PAPE-N-biotin, like Ox-PAPC, induced interleukin-8 (IL-8) protein synthesis and stimulated IL-8, low density lipoprotein receptor, heme oxygenase-1, and activating transcription factor-3 mRNA expression in HAECs.	ox-pape	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
18071189-5	2008	Ox-PAPE-N-biotin, like Ox-PAPC, induced interleukin-8 (IL-8) protein synthesis and stimulated IL-8, low density lipoprotein receptor, heme oxygenase-1, and activating transcription factor-3 mRNA expression in HAECs.	ox-pape	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
18071189-5	2008	Ox-PAPE-N-biotin, like Ox-PAPC, induced interleukin-8 (IL-8) protein synthesis and stimulated IL-8, low density lipoprotein receptor, heme oxygenase-1, and activating transcription factor-3 mRNA expression in HAECs.	ox-pape	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
18071189-5	2008	Ox-PAPE-N-biotin, like Ox-PAPC, induced interleukin-8 (IL-8) protein synthesis and stimulated IL-8, low density lipoprotein receptor, heme oxygenase-1, and activating transcription factor-3 mRNA expression in HAECs.	n-biotin	8-16	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
18071189-5	2008	Ox-PAPE-N-biotin, like Ox-PAPC, induced interleukin-8 (IL-8) protein synthesis and stimulated IL-8, low density lipoprotein receptor, heme oxygenase-1, and activating transcription factor-3 mRNA expression in HAECs.	n-biotin	8-16	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
18071189-5	2008	Ox-PAPE-N-biotin, like Ox-PAPC, induced interleukin-8 (IL-8) protein synthesis and stimulated IL-8, low density lipoprotein receptor, heme oxygenase-1, and activating transcription factor-3 mRNA expression in HAECs.	n-biotin	8-16	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
18344608-5	2008	Furthermore, only GL inhibited DNA binding of p65 to the IL-8 promoter region.	Glycyrrhizic Acid	18-20	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
18344608-6	2008	These findings indicated that GL had a glucocorticoid-like inhibitory effect on IL-8 production via a mechanism that differs from that of glucocorticoids.	Glycyrrhizic Acid	30-32	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
17997161-6	2008	Interestingly, PGN-induced IL-8 expression was inhibited by nystatin, a specific inhibitor for lipid rafts, but not by chlorpromazine, a specific inhibitor for clathrin-coated pits.	Nystatin	60-68	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
18093085-10	2008	IL-8 levels were higher in infants with hypoxemia and inversely related with SaO(2) levels.	sao(2)	77-83	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
18066713-3	2008	When coincubating A549 with LPS and meta-iodobenzylguanidine or novobiocin, selective arginine-dependent ART-inhibitors, the release of IL-6 and IL-8 was inhibited in a concentration-dependent manner.	3-Iodobenzylguanidine	36-60	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
18066713-3	2008	When coincubating A549 with LPS and meta-iodobenzylguanidine or novobiocin, selective arginine-dependent ART-inhibitors, the release of IL-6 and IL-8 was inhibited in a concentration-dependent manner.	Novobiocin	64-74	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
18066713-3	2008	When coincubating A549 with LPS and meta-iodobenzylguanidine or novobiocin, selective arginine-dependent ART-inhibitors, the release of IL-6 and IL-8 was inhibited in a concentration-dependent manner.	Arginine	86-94	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
18089838-7	2008	TCDD-mediated inductions of various AhR targets, such as the drug metabolizing CYP1B1, the cytokine interleukin-1beta, the chemokines interleukin-8 and CCL1, the adhesion molecule beta7 integrin, and the AhR repressor, were also prevented by KN-93 in human macrophages.	Polychlorinated Dibenzodioxins	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	134-147
18079996-6	2008	The magnitude of the postoperative increase in plasma MIF was associated with increased number of days required for mechanical ventilation (r = 0.553; P = 0.012), and peak plasma IL-8 correlated significantly with the fraction of inhaled oxygen (FiO(2)) required immediately after surgery (r = 0.510; P = 0.02).	Oxygen	238-244	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
18477937-10	2008	IL-6 secretion was elevated in all hyperoxic groups at 24 hrs (p &lt; .001), and both IL-6 and IL-8 levels were greater in the 40% FiO2 group compared with all other groups at 72 hrs (p &lt; .01).	fio2	131-135	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
18214943-8	2008	Zn supplementation was marginally effective in reducing percentage increase in plasma IL-6 and IL-8 while increasing the percentage change in ex vivo generation of IL-2 in isolated mononuclear cell.	Zinc	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
18327406-8	2008	Under serum-free conditions, heparin demonstrated dose-dependent anti-inflammatory effects, significantly reducing secretion of pro-inflammatory cytokines (IL-1beta, IL-6, IL-8, and TNF-alpha) in response to LPS-stimulation of THP-1 cells and primary monocytes.	Heparin	29-36	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
18630691-0	2008	[Effect of N-acetylcysteine on lipopolysaccharide stimulating IL-8 expression of human uterine smooth cell].	Acetylcysteine	11-27	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
18630691-1	2008	OBJECTIVE: To investigate the effects of N-acetylcysteine (NAC)on the expression of IL-8 and the activity of NF-kappaB, which are induced by lipopolysaccharide (LPS) in human uterine smooth cell.	Acetylcysteine	41-57	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
18191873-12	2008	Interestingly, ET-1-induced production of IL-8 was also inhibited by celecoxib.	Celecoxib	69-78	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
18494145-9	2008	The lack of IL-8 production by trimellitic anhydride can be explained by the rapid hydrolysis of this chemical in water to trimellitic acid, which is not an allergen.	trimellitic anhydride	31-52	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
17996917-0	2008	Fluoride-induced IL-8 release in human epithelial lung cells: relationship to EGF-receptor-, SRC- and MAP-kinase activation.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
18494145-9	2008	The lack of IL-8 production by trimellitic anhydride can be explained by the rapid hydrolysis of this chemical in water to trimellitic acid, which is not an allergen.	trimellitic acid	123-139	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
18494145-13	2008	By Western blot analysis we could indeed demonstrate p38 activation by all chemical allergens tested and, using the selective p38 MAPK inhibitor SB203580, a significant modulation of allergen-induced IL-8 release could be achieved in all cases.	SB 203580	145-153	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
17583554-5	2008	hMSCs, induced to differentiate with osteogenic medium (OGM) containing ascorbate, beta-glycerophosphate (beta-GP), and dexamethasone (DEX), showed an increase in mRNA and protein secretion of the ELR(+) CXC chemokines CXCL8 and CXCL1.	beta-glycerophosphoric acid	106-113	C-X-C motif chemokine ligand 8	Homo sapiens	219-224
17583554-5	2008	hMSCs, induced to differentiate with osteogenic medium (OGM) containing ascorbate, beta-glycerophosphate (beta-GP), and dexamethasone (DEX), showed an increase in mRNA and protein secretion of the ELR(+) CXC chemokines CXCL8 and CXCL1.	Dexamethasone	135-138	C-X-C motif chemokine ligand 8	Homo sapiens	219-224
17583554-8	2008	Inhibition of the glucocorticoid receptor with mifepristone only partially inhibits DEX-stimulated CXCL8 expression indicating both glucocorticoid receptor dependent and independent pathways.	Mifepristone	47-59	C-X-C motif chemokine ligand 8	Homo sapiens	99-104
17583554-8	2008	Inhibition of the glucocorticoid receptor with mifepristone only partially inhibits DEX-stimulated CXCL8 expression indicating both glucocorticoid receptor dependent and independent pathways.	Dexamethasone	84-87	C-X-C motif chemokine ligand 8	Homo sapiens	99-104
17996917-4	2008	The ERK1/2-inhibitor PD98059, the p38-inhibitor SB202190 and the JNK1/2-inhibitor SP600125 partially inhibited the fluoride-induced IL-8 response.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	21-28	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
17996917-4	2008	The ERK1/2-inhibitor PD98059, the p38-inhibitor SB202190 and the JNK1/2-inhibitor SP600125 partially inhibited the fluoride-induced IL-8 response.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	48-56	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
17996917-4	2008	The ERK1/2-inhibitor PD98059, the p38-inhibitor SB202190 and the JNK1/2-inhibitor SP600125 partially inhibited the fluoride-induced IL-8 response.	pyrazolanthrone	82-90	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
17996917-4	2008	The ERK1/2-inhibitor PD98059, the p38-inhibitor SB202190 and the JNK1/2-inhibitor SP600125 partially inhibited the fluoride-induced IL-8 response.	Fluorides	115-123	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
17996917-6	2008	Treatment with siRNA against JNK2 also reduced the IL-8 response to fluoride.	Fluorides	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
17996917-10	2008	AG1478, an EGFR-inhibitor, partially reduced the fluoride-induced IL-8 response and the phosphorylation of JNK1/2 and ERK1/2, but less the phosphorylation of p38.	RTKI cpd	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
17996917-10	2008	AG1478, an EGFR-inhibitor, partially reduced the fluoride-induced IL-8 response and the phosphorylation of JNK1/2 and ERK1/2, but less the phosphorylation of p38.	Fluorides	49-57	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
18642783-10	2008	The levels of TNF-alpha, IL-6, and IL-8 of the high concentration Gln 2 h groups were all significantly higher then those of the concentration Gln 0.5 h groups (all P &lt;0.01), however, there was not significant difference in the level of IL-1beta between the high concentration 0.5 h and 2 h Gln groups.	Glutamine	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
17981896-7	2008	On the other hand, in the presence of ATP (3 mM) and beryllium fluoride (10 mM NaF and 300 microM BeCl(2)), we observed the formation of a stable symmetric complex, suggesting the existence of a transiently formed symmetric complex during the chaperonin cycle.	Adenosine Triphosphate	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
17981896-7	2008	On the other hand, in the presence of ATP (3 mM) and beryllium fluoride (10 mM NaF and 300 microM BeCl(2)), we observed the formation of a stable symmetric complex, suggesting the existence of a transiently formed symmetric complex during the chaperonin cycle.	beryllium fluoride	53-71	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
18250478-9	2008	We have confirmed the increased expression of P2Y(6) by challenging intestinal epithelial cell-6 and Caco-2/15 cells with TNF-alpha and IFN-gamma and showing that stimulation of epithelial cells by UDP results in an increased expression and release of CXCL8 by an ERK1/2-dependent mechanism.	Uridine Diphosphate	198-201	C-X-C motif chemokine ligand 8	Homo sapiens	252-257
17996917-12	2008	In conclusion, our findings suggest that the fluoride-induced IL-8 release involves the combined activation of ERK1/2, JNK1/2 and p38, and that the phosphorylation of these kinases, and in particular JNK1/2 and ERK1/2, partly, is mediated via a SFK-dependent EGFR-linked pathway.	Fluorides	45-53	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
17996917-1	2008	Exposure of human epithelial lung cells to fluorides is known to induce a marked increase in the release of interleukin (IL)-8, a chemokine involved in neutrophil recruitment.	Fluorides	43-52	C-X-C motif chemokine ligand 8	Homo sapiens	108-126
18155175-1	2008	BACKGROUND: In a previous report (Higai K et al., Biol Pharm Bull, 2007), glycated human serum albumin (Glc-HSA) was found to induce interleukin-8 (IL-8) mRNA expression in human monocyte-derived U937 cells through a reactive oxygen species (ROS)-dependent pathway; however, Glc-HSA signaling has not been elucidated in macrophages.	Reactive Oxygen Species	217-240	C-X-C motif chemokine ligand 8	Homo sapiens	133-146
17709599-4	2008	Using CF bronchial epithelial cells (IB3-1) in vitro, exogenous PGE-2 induces IL-8 release in a dose-dependent manner.	Dinoprostone	64-69	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
17709599-6	2008	Inhibition of cyclooxygenase (Cox)-2 with NS-398 was associated with reductions in Cox-2 (2-fold) and IL-6 (1.3-fold) mRNA transcripts, and in IL-8 and PGE-2 chemokine secretion.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	42-48	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
17709599-9	2008	We conclude that PGE-2 stimulates IL-8 production through the CHOP transcription factor in CF cells.	Dinoprostone	17-22	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
17970647-3	2008	Surprisingly, treatment of MonoMac6 cells with the natural PPARgamma ligand 15-deoxy-Delta12,14-prostaglandin J2 led to increased cytokine (IL-8) release in response to either TNF-alpha or CS extract (CSE).	14-prostaglandin j2	93-112	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
17970647-3	2008	Surprisingly, treatment of MonoMac6 cells with the natural PPARgamma ligand 15-deoxy-Delta12,14-prostaglandin J2 led to increased cytokine (IL-8) release in response to either TNF-alpha or CS extract (CSE).	Cesium	189-191	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
18155175-1	2008	BACKGROUND: In a previous report (Higai K et al., Biol Pharm Bull, 2007), glycated human serum albumin (Glc-HSA) was found to induce interleukin-8 (IL-8) mRNA expression in human monocyte-derived U937 cells through a reactive oxygen species (ROS)-dependent pathway; however, Glc-HSA signaling has not been elucidated in macrophages.	Reactive Oxygen Species	217-240	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
18155175-1	2008	BACKGROUND: In a previous report (Higai K et al., Biol Pharm Bull, 2007), glycated human serum albumin (Glc-HSA) was found to induce interleukin-8 (IL-8) mRNA expression in human monocyte-derived U937 cells through a reactive oxygen species (ROS)-dependent pathway; however, Glc-HSA signaling has not been elucidated in macrophages.	Reactive Oxygen Species	242-245	C-X-C motif chemokine ligand 8	Homo sapiens	133-146
18155175-1	2008	BACKGROUND: In a previous report (Higai K et al., Biol Pharm Bull, 2007), glycated human serum albumin (Glc-HSA) was found to induce interleukin-8 (IL-8) mRNA expression in human monocyte-derived U937 cells through a reactive oxygen species (ROS)-dependent pathway; however, Glc-HSA signaling has not been elucidated in macrophages.	Reactive Oxygen Species	242-245	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
18155175-1	2008	BACKGROUND: In a previous report (Higai K et al., Biol Pharm Bull, 2007), glycated human serum albumin (Glc-HSA) was found to induce interleukin-8 (IL-8) mRNA expression in human monocyte-derived U937 cells through a reactive oxygen species (ROS)-dependent pathway; however, Glc-HSA signaling has not been elucidated in macrophages.	Glucose	104-107	C-X-C motif chemokine ligand 8	Homo sapiens	133-146
18155175-1	2008	BACKGROUND: In a previous report (Higai K et al., Biol Pharm Bull, 2007), glycated human serum albumin (Glc-HSA) was found to induce interleukin-8 (IL-8) mRNA expression in human monocyte-derived U937 cells through a reactive oxygen species (ROS)-dependent pathway; however, Glc-HSA signaling has not been elucidated in macrophages.	Glucose	104-107	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
17975552-6	2008	Consistent with repression of canonical IKK signaling pathway, the induction of NF-kappaB target genes monocyte chemoattractant protein, intercellular adhesion molecule-1, cyclooxygenase-2 and IL-8 is also inhibited by R-Roscovitine.	Roscovitine	219-232	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
18037374-0	2008	Simvastatin enhances endothelial differentiation of peripheral blood mononuclear cells in hypercholesterolemic patients and induces pro-angiogenic cytokine IL-8 secretion from monocytes.	Simvastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
18181043-12	2008	Concentrations of IL-8 and VEGF in the conditioned medium of OUR-10 and NC65 cells also decreased following DEX treatment, with the inhibition of nuclear translocation of NF-kappa B.	Dexamethasone	108-111	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
18181043-13	2008	CONCLUSION: DEX treatment is a candidate for advanced RCC therapy by inhibiting the activation of NF-kappa B and its downstream products such as IL-6, IL-8 and VEGF.	Dexamethasone	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
18037374-11	2008	In response to simvastatin, IL-8 was mainly increased in monocyte culture supernatants while VEGF increased in smooth muscle cell culture supernatants.	Simvastatin	15-26	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
18037374-14	2008	CONCLUSION: Simvastatin enhances endothelial differentiation of peripheral blood mononuclear cells in patients with hypercholesterolemia and increases pro-angiogenic cytokine IL-8 secretion from monocytes.	Simvastatin	12-23	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
17555752-1	2008	OBJECTIVE: To evaluate the influence of peroxisome proliferator-activated receptor-gamma (PPAR gamma) ligand (pioglitazone) on tumor necrosis factor-alpha (TNF-alpha)-induced interleukin-8 (IL-8) expression in endometriotic stromal cells (ESCs) and on proliferation of ESCs.	Pioglitazone	110-122	C-X-C motif chemokine ligand 8	Homo sapiens	175-188
18259970-4	2008	This study examined the effects of fluticasone, salmeterol, and agents which raise intracellular cAMP (cilomilast and db-cAMP) on the expression of IP-10 and IL-8 protein and mRNA.	Fluticasone	35-46	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
18259970-4	2008	This study examined the effects of fluticasone, salmeterol, and agents which raise intracellular cAMP (cilomilast and db-cAMP) on the expression of IP-10 and IL-8 protein and mRNA.	Salmeterol Xinafoate	48-58	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
18259970-4	2008	This study examined the effects of fluticasone, salmeterol, and agents which raise intracellular cAMP (cilomilast and db-cAMP) on the expression of IP-10 and IL-8 protein and mRNA.	Cyclic AMP	97-101	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
18259970-4	2008	This study examined the effects of fluticasone, salmeterol, and agents which raise intracellular cAMP (cilomilast and db-cAMP) on the expression of IP-10 and IL-8 protein and mRNA.	Cilomilast	103-113	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
18259970-4	2008	This study examined the effects of fluticasone, salmeterol, and agents which raise intracellular cAMP (cilomilast and db-cAMP) on the expression of IP-10 and IL-8 protein and mRNA.	Bucladesine	118-125	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
18259970-7	2008	Fluticasone (0.1 nM to 1 microM) increased IP-10 but reduced IL-8 protein release without changing IP-10 mRNA levels assessed by real time RT-PCR.	Fluticasone	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
18222974-9	2008	In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells.	ANAVACYM protocol	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
18222974-9	2008	In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells.	Tetradecanoylphorbol Acetate	33-64	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
18222974-9	2008	In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells.	Calcium	69-76	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
18222974-9	2008	In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells.	Calcimycin	87-93	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
18222974-9	2008	In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells.	pmaci	95-100	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
17555752-7	2008	We determined the effect of pioglitazone on the production of TNF-alpha-induced IL-8 protein in culture supernatant of ESCs using ELISA.	Pioglitazone	28-40	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
17555752-13	2008	Treating ESCs with 0.1-10 microM of pioglitazone significantly reduced the TNF-alpha-induced IL-8 production.	Pioglitazone	36-48	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
17555752-18	2008	CONCLUSION(S): The present study demonstrates for the first time that PPAR gamma is expressed in ESCs, and that pioglitazone reduced IL-8 secretion and the proliferation of ESCs.	Pioglitazone	112-124	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
18195160-10	2008	Circulating concentrations of osteopontin, monocyte chemoattractant protein-1, basic fibroblast growth factor, interleukin-8, and interleukin-10 were significantly reduced only by eplerenone.	Eplerenone	180-190	C-X-C motif chemokine ligand 8	Homo sapiens	111-124
17941093-0	2008	Characterization of epithelial IL-8 response to inflammatory bowel disease mucosal E. coli and its inhibition by mesalamine.	Mesalamine	113-123	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
17662042-9	2008	IFN-gamma inhibited phorbol 12-myristate 13-acetate (PMA)-induced release of IL-8 and CCL1 (by 47 and 38%).	Tetradecanoylphorbol Acetate	20-51	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
17662042-9	2008	IFN-gamma inhibited phorbol 12-myristate 13-acetate (PMA)-induced release of IL-8 and CCL1 (by 47 and 38%).	Tetradecanoylphorbol Acetate	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
17662042-12	2008	IFN-gamma-induced inhibition of chemokine expression and release was NO dependent, as treatment with the NOS inhibitor N(G)-nitro-l-arginine methyl ester (l-NAME) reduced the IFN-gamma inhibitory effect on IL-8 and CCL1 mRNA expression.	NG-Nitroarginine Methyl Ester	155-161	C-X-C motif chemokine ligand 8	Homo sapiens	206-210
17941093-9	2008	IL-8 release was mediated by extracellular-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) and inhibited by mesalamine, but not hydrocortisone, at therapeutic concentrations.	Mesalamine	131-141	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
17662042-12	2008	IFN-gamma-induced inhibition of chemokine expression and release was NO dependent, as treatment with the NOS inhibitor N(G)-nitro-l-arginine methyl ester (l-NAME) reduced the IFN-gamma inhibitory effect on IL-8 and CCL1 mRNA expression.	NG-Nitroarginine Methyl Ester	119-153	C-X-C motif chemokine ligand 8	Homo sapiens	206-210
17913284-3	2008	Column tests comparing pure NaF solutions, synthetic SPL solutions, and actual SPL leachate indicate that the complex chemical matrix of the SPL leachate can impact fluoride removal significantly.	Fluorides	165-173	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
18203325-2	2008	We have also reported that a certain pharmacological concentration of simvastatin, i.e., 0.05-0.1 microM, inhibits the production of interleukin 6 (IL-6) and IL-8 and the cell proliferation induced by tumor necrosis factor-alpha (TNF-alpha) in fibroblast-like synoviocytes (FLS) derived from patients with RA in vitro.	Simvastatin	70-81	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
18203325-11	2008	CONCLUSION: These data, together with our previous report, suggest that low (pharmacological range) and high concentrations of simvastatin affect FLS differently: (1) at a low concentration, it inhibits IL-6 and IL-8 production and the cell proliferation of FLS induced by TNF-alpha (2) at high concentrations, it induces apoptosis in FLS.	Simvastatin	127-138	C-X-C motif chemokine ligand 8	Homo sapiens	212-216
18006645-5	2008	Moreover, exogenously applied LPA induces FLS migration and secretion of IL-8/IL-6, whereas the LPA(3) agonist l-sn-1-O-oleoyl-2-methyl-glyceryl-3-phosphothionate (2S-OMPT) stimulates cytokine synthesis but not cell motility.	lysophosphatidic acid	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
17941093-9	2008	IL-8 release was mediated by extracellular-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) and inhibited by mesalamine, but not hydrocortisone, at therapeutic concentrations.	Hydrocortisone	151-165	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
17941093-12	2008	The IL-8 release is MAPK-dependent and inhibited by mesalamine.	Mesalamine	52-62	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
18303186-6	2008	Kinetic studies revealed that TNF-alpha and IL-8 release occurred in a time-dependent manner with release of two cytokines beginning at 3 hr post-exposure to well-known haptens, DNCB and NiSO(4).	Dinitrochlorobenzene	178-182	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
18303186-6	2008	Kinetic studies revealed that TNF-alpha and IL-8 release occurred in a time-dependent manner with release of two cytokines beginning at 3 hr post-exposure to well-known haptens, DNCB and NiSO(4).	niso	187-191	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
17962359-7	2008	CaSR stimulation by extracellular calcium or agonists, such as spermine or Mg(2+), caused ERK1 and 2 activation, intracellular calcium concentration ([Ca(2+)](i)) mobilization (as assessed by microspecfluorometry using Fluo-4), and secretion of the multifunctional cytokine IL-8 (CX-CL8).	Calcium	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	274-278
18069112-1	2008	Sodium fluoride (NaF) has been shown to be cytotoxic and produces inflammatory responses in humans.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
18607954-1	2008	CONCLUSIONS: The results suggest that the anti-inflammatory effect of caffeic acid phenethyl ester (CAPE) is due to its inhibition of tumor necrosis factor (TNF)-alpha expression and interleukin (IL)-8 production.	caffeic acid phenethyl ester	70-98	C-X-C motif chemokine ligand 8	Homo sapiens	183-201
18607954-1	2008	CONCLUSIONS: The results suggest that the anti-inflammatory effect of caffeic acid phenethyl ester (CAPE) is due to its inhibition of tumor necrosis factor (TNF)-alpha expression and interleukin (IL)-8 production.	caffeic acid phenethyl ester	100-104	C-X-C motif chemokine ligand 8	Homo sapiens	183-201
18717605-6	2008	Following treatment with dacarbazine, melanoma cells activate the extracellular signal-regulated kinase pathway, which results in over-expression and secretion of interleukin (IL)-8 and vascular endothelial growth factor.	Dacarbazine	25-36	C-X-C motif chemokine ligand 8	Homo sapiens	163-181
17947611-3	2008	Macrolide antibiotics, such as clarithromycin, have in vitro efficacy against IL-8 and neutrophils, key inflammatory mediators in noneosinophilic asthma.	macrolide antibiotics	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
17947611-3	2008	Macrolide antibiotics, such as clarithromycin, have in vitro efficacy against IL-8 and neutrophils, key inflammatory mediators in noneosinophilic asthma.	Clarithromycin	31-45	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
17947611-9	2008	Clarithromycin therapy significantly reduced airway concentrations of IL-8 and neutrophil numbers and improved quality-of-life scores compared with placebo.	Clarithromycin	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
17947611-12	2008	CONCLUSIONS: Clarithromycin therapy can modulate IL-8 levels and neutrophil accumulation and activation in the airways of patients with refractory asthma.	Clarithromycin	13-27	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
18497054-5	2008	Treatment with the tyrosine kinase inhibitor gefitinib (Iressa) returned the expression levels of IL-8 and GRO back to the baseline observed in HER2-negative MCF-7 BC cells.	Gefitinib	45-54	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
19051345-6	2008	Analysis of the anti-inflammatory effects of ursolic acid and oleanolic acid, the triterpene compounds present in PPY, showed that ursolic acid significantly inhibited LPS-induced IL-8 production, NF-kappaB activation, and iNOS mRNA expression, whereas oleanolic acid did not have these effects.	Oleanolic Acid	62-76	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
19051345-6	2008	Analysis of the anti-inflammatory effects of ursolic acid and oleanolic acid, the triterpene compounds present in PPY, showed that ursolic acid significantly inhibited LPS-induced IL-8 production, NF-kappaB activation, and iNOS mRNA expression, whereas oleanolic acid did not have these effects.	ursolic acid	131-143	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
17962359-7	2008	CaSR stimulation by extracellular calcium or agonists, such as spermine or Mg(2+), caused ERK1 and 2 activation, intracellular calcium concentration ([Ca(2+)](i)) mobilization (as assessed by microspecfluorometry using Fluo-4), and secretion of the multifunctional cytokine IL-8 (CX-CL8).	Calcium	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	280-286
17962359-7	2008	CaSR stimulation by extracellular calcium or agonists, such as spermine or Mg(2+), caused ERK1 and 2 activation, intracellular calcium concentration ([Ca(2+)](i)) mobilization (as assessed by microspecfluorometry using Fluo-4), and secretion of the multifunctional cytokine IL-8 (CX-CL8).	Spermine	63-71	C-X-C motif chemokine ligand 8	Homo sapiens	274-278
17962359-7	2008	CaSR stimulation by extracellular calcium or agonists, such as spermine or Mg(2+), caused ERK1 and 2 activation, intracellular calcium concentration ([Ca(2+)](i)) mobilization (as assessed by microspecfluorometry using Fluo-4), and secretion of the multifunctional cytokine IL-8 (CX-CL8).	Spermine	63-71	C-X-C motif chemokine ligand 8	Homo sapiens	280-286
18079439-3	2008	The NO synthase inhibitor N(G)-nitro-l-arginine methyl ester (L-NAME) significantly (P &lt; 0.001) enhanced IL-8-induced migration by up to 45%.	NG-Nitroarginine Methyl Ester	26-60	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
17962359-7	2008	CaSR stimulation by extracellular calcium or agonists, such as spermine or Mg(2+), caused ERK1 and 2 activation, intracellular calcium concentration ([Ca(2+)](i)) mobilization (as assessed by microspecfluorometry using Fluo-4), and secretion of the multifunctional cytokine IL-8 (CX-CL8).	magnesium ion	75-81	C-X-C motif chemokine ligand 8	Homo sapiens	274-278
18079439-3	2008	The NO synthase inhibitor N(G)-nitro-l-arginine methyl ester (L-NAME) significantly (P &lt; 0.001) enhanced IL-8-induced migration by up to 45%.	NG-Nitroarginine Methyl Ester	62-68	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
18079439-5	2008	Antibodies to L-selectin or PSGL-1 had no effect on IL-8-induced migration but prevented the increased migration to IL-8 induced by L-NAME.	NG-Nitroarginine Methyl Ester	132-138	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
17962359-7	2008	CaSR stimulation by extracellular calcium or agonists, such as spermine or Mg(2+), caused ERK1 and 2 activation, intracellular calcium concentration ([Ca(2+)](i)) mobilization (as assessed by microspecfluorometry using Fluo-4), and secretion of the multifunctional cytokine IL-8 (CX-CL8).	magnesium ion	75-81	C-X-C motif chemokine ligand 8	Homo sapiens	280-286
18079439-8	2008	Only microparticles from L-NAME and not untreated or D-NAME-treated neutrophils induced a significant (P &lt; 0.01) increase in IL-8-induced migration and transendothelial migration.	NG-Nitroarginine Methyl Ester	25-31	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
18006311-1	2008	A series of novel and potent 3,4-diamino-2,5-thiadiazole-1-oxides were prepared and found to show excellent binding affinities for CXCR2 and CXCR1 receptors and excellent inhibitory activity of Gro-alpha and IL-8 mediated in vitro hPMN MPO release of CXCR2 and CXCR1 expressing cell lines.	3,4-diamino-2,5-thiadiazole-1-oxides	29-65	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
17405871-7	2008	The cord blood cortisol concentration was significantly increased in the presence of chorioamnionitis or funisitis and was moderately correlated with cord blood IL6 (r = 0.64, p&lt;0.01) and IL8 (r = 0.52, p&lt;0.01).	Hydrocortisone	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	191-194
18023202-0	2008	IL-8 induces imbalances between nitric oxide and endothelin-1, and also between plasminogen activator inhibitor-1 and tissue-type plasminogen activator in cultured endothelial cells.	Nitric Oxide	32-44	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
18781069-1	2008	BACKGROUND: Large increases in salivary fluoride were reported 1 h after a calcium pre-rinse/NaF rinse.	salivary fluoride	31-48	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
18639962-11	2008	Inhibition of ERK1/2, JNK1/2 and p38 MAPK with PD98059, SP600125 and SB203580, respectively, led to the suppression of the shear stress-induced IL-8 gene expression (P&lt;0.01), which was also blocked by JNK1/2 siRNA (small interfering RNA) (P&lt;0.01).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	47-54	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
18639962-11	2008	Inhibition of ERK1/2, JNK1/2 and p38 MAPK with PD98059, SP600125 and SB203580, respectively, led to the suppression of the shear stress-induced IL-8 gene expression (P&lt;0.01), which was also blocked by JNK1/2 siRNA (small interfering RNA) (P&lt;0.01).	pyrazolanthrone	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
18639962-11	2008	Inhibition of ERK1/2, JNK1/2 and p38 MAPK with PD98059, SP600125 and SB203580, respectively, led to the suppression of the shear stress-induced IL-8 gene expression (P&lt;0.01), which was also blocked by JNK1/2 siRNA (small interfering RNA) (P&lt;0.01).	SB 203580	69-77	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
17725646-4	2008	A S. Typhi tviABCDEvexABCDE deletion mutant, but not a tviBCDEvexABCDE deletion mutant, elicited increased IL-8 production, which could be reduced to wild-type levels by introducing the cloned tviA regulatory gene.	tviabcdevexabcde	11-27	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
17725646-8	2008	Introduction of tviA into S. enterica serotype Typhimurium reduced flagellin secretion and IL-8 expression.	tvia	16-20	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
19364068-9	2008	Decreased MCP-1, IL-6, and IL-8 expression indicated that APS-purified islets were possibly exposed to less proinflammatory stress.	aps	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
18180640-13	2008	After exposure to morphine sulfate, adult neutrophils showed no difference in IL-8 receptor expression, whereas newborn neutrophils expressed fewer IL-8 receptors.	Morphine	18-34	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
18180640-16	2008	The differential effect may be explained in part by the reduction of IL-8 receptors of newborn neutrophils after morphine exposure.	Morphine	113-121	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
18854128-10	2008	348 kPa) moduli IPN surfaces attenuated IL-8 secretion.	ipn	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
18472047-7	2008	Results showed that ATP decreased the rise in concentrations of TNF-alpha, interferon-gamma (IFN-gamma) and IL-1beta, but increased concentrations of IL-8 and IL-10.	Adenosine Triphosphate	20-23	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
18668392-8	2008	Dexamethasone enhanced IL-10 (p = 0.013) and suppressed IL-1beta, TNF-alpha, interleukin 6 (IL-6), and interleukin 8 (IL-8) (p = 0.013).	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	103-116
18668392-8	2008	Dexamethasone enhanced IL-10 (p = 0.013) and suppressed IL-1beta, TNF-alpha, interleukin 6 (IL-6), and interleukin 8 (IL-8) (p = 0.013).	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
18488441-9	2008	Sputum supernatant IL-8 correlated with total neutrophil count per gram of sputum (r = 0.52, p = 0.04) and with EBC pH (r = -0.59, p = 0.02).	NSC638702	112-115	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
17965029-6	2008	A significant inhibitory effect of besifloxacin was observed at 0.1 mg/L for IL-1alpha, at 1 mg/L for G-CSF, IL-1ra and IL-6 and at 30 mg/L for GM-CSF, IL-12p40, IL-1beta, IL-8, IP-10, MCP-1 and MIP-1alpha.	besifloxacin	35-47	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
17707405-6	2008	RESULTS: The IL-8 production by the HUVECs was significantly higher in the high glucose culture than in the control culture (glucose concentration of 100 mg/dL) (P &lt; 0.05).	Glucose	80-87	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
18447141-8	2008	These results support previous data suggesting an important role for IL-8 and drug-specific T cells in the pathogenesis ofAGEP and imply that the reaction was specific to tetrazepam with no cross-reactivity to other benzodiazepines.	tetrazepam	171-181	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
18077529-1	2008	Although (18)F-labeled NaF was the first widely used agent for skeletal scintigraphy, it quickly fell into disuse after the introduction of (99m)Tc-labeled bone-imaging agents.	Fluorine	13-14	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
17541958-7	2008	CS also increased the phosphorylation of MAPK"s and the production of IL-8 but interestingly only in stimulated cells.	Cesium	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
17947496-5	2008	Treatment of cells with 20-HETE markedly increased levels of prostaglandin (PG) E(2) and 8-epi-isoprostane PGF(2alpha), commonly used markers of activation and oxidative stress, and most prominently, interleukin-8, a potent neutrophil chemotactic factor whose overproduction by the endothelium is a key feature of vascular injury.	20-Hete	24-31	C-X-C motif chemokine ligand 8	Homo sapiens	200-213
17707405-6	2008	RESULTS: The IL-8 production by the HUVECs was significantly higher in the high glucose culture than in the control culture (glucose concentration of 100 mg/dL) (P &lt; 0.05).	Glucose	125-132	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
17707405-7	2008	Moreover, the hyperglycemia associated with elevated TNF-alpha was found to enhance the level of IL-8 production by the HUVECs cultured at all glucose concentrations and over both time courses, compared to the control (P &lt; 0.05).	Glucose	143-150	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
18227044-0	2008	[Effect of glutamine on serum interleukin-8 and tumor necrosis factor-alpha levels in patients with severe pancreatitis].	Glutamine	11-20	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
18052220-6	2008	In the presence of NaF, hydroxyl radicals were detected by an ethanol scavenger, whereas such radicals were not found in the absence of NaF.	Hydroxyl Radical	24-41	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
18052220-6	2008	In the presence of NaF, hydroxyl radicals were detected by an ethanol scavenger, whereas such radicals were not found in the absence of NaF.	Ethanol	62-69	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
18227044-1	2008	OBJECTIVE: To observe the changes in serum interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) after intravenous administration of alanyl-glutamine (Gln) in patients with severe pancreatitis.	alanylglutamine	144-160	C-X-C motif chemokine ligand 8	Homo sapiens	43-56
18227044-1	2008	OBJECTIVE: To observe the changes in serum interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) after intravenous administration of alanyl-glutamine (Gln) in patients with severe pancreatitis.	alanylglutamine	144-160	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
18227044-1	2008	OBJECTIVE: To observe the changes in serum interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) after intravenous administration of alanyl-glutamine (Gln) in patients with severe pancreatitis.	alanylglutamine	162-165	C-X-C motif chemokine ligand 8	Homo sapiens	43-56
18227044-4	2008	RESULTS: On day of Gln administration, the plasma glutamine level in patients of Gln group increased significantly (P&lt;0.01), and serum IL-8 and TNF-alpha levels decreased significantly (P&gt;0.05) in comparison with those of the control group.	alanylglutamine	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
18227044-6	2008	CONCLUSION: Gln-enriched TPN may improve the clinical outcomes of patients with severe pancreatitis probably by decreasing serum IL-8 and TNF-alpha levels.	alanylglutamine	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
19001760-0	2008	[Anti-fungal drug liranaftate suppresses fungal element-promoted production of IL-8 in normal human keratinocytes].	liranaftate	18-29	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
18332643-3	2008	OBJECTIVES: We hypothesize that end-tidal carbon monoxide corrected for inhaled CO (ETCOc), malondialdehyde (MDA) (markers of oxidative stress) and proinflammatory cytokine (IL-6, IL-8) production are higher in infants of preeclamptic mothers with HELLP syndrome than in those of preeclamptic mothers without HELLP syndrome.	Carbon Monoxide	42-57	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
17716784-4	2008	Under certain conditions, however, stress hormones, substance P, ATP and the activation of the corticotropin-releasing hormone/substance P-histamine axis may actually facilitate inflammation, through induction of interleukin (IL)-1, IL-6, IL-8, IL-18, tumor necrosis factor (TNF)-alpha and CRP production.	Histamine	139-148	C-X-C motif chemokine ligand 8	Homo sapiens	239-243
19001760-3	2008	The fungal elements beta-D-glucan and trichophytin from Trichophyton rubrum and Trichophyton mentagrophytes augmented production of IL-8 and IL-1 alpha of cultured normal human epidermal keratinocytes.	maltotriose	20-33	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
19001760-5	2008	Next we examined the effect of liranaftate, a representative Japanese thiocarbamate antifungal agent, on the production of IL-8 and IL-1 alpha.	liranaftate	31-42	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
19001760-7	2008	Augmented production of IL-8 was profoundly suppressed by the addition of liranaftate to the culture in a dose-dependent manner.	liranaftate	74-85	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
19001760-8	2008	Clinically, liranaftate an antifungal drug with IL-8-decreasing activity may reduce infiltration of neutrophils in the skin and their invasion into the epidermis.	liranaftate	12-23	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
18946510-6	2008	Applying a whole blood assay, IC(50) values of pro-inflammatory cytokine release (TNF-alpha, IL-6, IL-8, IL-1beta) were found to be positively correlated with the K(i)-values of the aforementioned polyphenols.	Polyphenols	197-208	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
19119578-1	2008	PURPOSE: To clinically evaluate the additional effect of adding 0.12% chlorhexidine digluconate (CHX) to a 0.05% sodium fluoride (NaF) mouth rinse in arresting active enamel caries lesions after 28 days.	Sodium Fluoride	113-128	C-X-C motif chemokine ligand 8	Homo sapiens	130-133
18846238-6	2008	Increases in H2O2 heavily contributed to the excessive IL-6 and IL-8 production in CF epithelia.	Hydrogen Peroxide	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
18677938-1	2008	UNLABELLED: The aim of our study was to characterize the priming effect of extracellular nucleotides on reactive oxygen species (ROS) production induced by formyl-methionyl-leucyl-phenylalanine (fMLP), interleukin-8 (IL-8), leukotriene B4 (LTB4), and platelet activating factor (PAF).	Reactive Oxygen Species	104-127	C-X-C motif chemokine ligand 8	Homo sapiens	202-215
18846238-8	2008	When cells are stimulated, differential expression in CF versus normal is enhanced; corresponding to an increase in H2O2 mediated production of IL-6 and IL-8.	Hydrogen Peroxide	116-120	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
18846238-11	2008	We conclude that a paradoxical decrease in Nrf-2 driven antioxidant responses in CF epithelia results in an increase in steady state H2O2, which in turn contributes to the overproduction of the pro-inflammatory cytokines IL-6 and IL-8.	Hydrogen Peroxide	133-137	C-X-C motif chemokine ligand 8	Homo sapiens	230-234
17692547-0	2008	Fluticasone, but not salmeterol, reduces cigarette smoke-induced production of interleukin-8 in human airway smooth muscle.	Fluticasone	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
17692547-3	2008	We have investigated the effect of fluticasone propionate, a corticosteroid, and salmeterol, a beta 2-adrenergic receptor agonist, on cigarette smoke extract-induced IL-8 production by human airway smooth muscle cells.	Salmeterol Xinafoate	81-91	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
17692547-6	2008	Fluticasone dose-dependently inhibited IL-8 release induced by cigarette smoke extract, TNFalpha or combined cigarette smoke extract and TNFalpha.	Fluticasone	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
17692547-7	2008	However, while IL-8 release in the presence of cigarette smoke extract alone was completely inhibited by fluticasone, IL-8 production induced by cigarette smoke extract and TNFalpha was only partially reduced.	Fluticasone	105-116	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
17692547-10	2008	Fluticasone but not salmeterol is effective in reducing cigarette smoke extract-induced IL-8 production in human airway smooth muscle cells.	Fluticasone	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
17692547-11	2008	The reduced inhibition of cigarette smoke extract- and TNFalpha-induced IL-8 release by fluticasone may explain why corticosteroids are less effective in chronic obstructive pulmonary disease where increased amounts of TNFalpha are present.	Fluticasone	88-99	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
17202807-9	2008	IL-8 levels in the supernatant obtained from SAEC cultures were increased following the addition of beta-D-glucan in vitro.	maltotriose	100-113	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
18677938-11	2008	Rottlerin (5 microM), a PKC delta inhibitor, almost abolished the effect of fMLP in the absence or in the presence of UTP, indicating that PKC delta is essential for the fMLP-induced effect; rottlerin also caused inhibition of ROS production induced by IL-8, LTB4 or PAF, however the priming effect of UTP was not affected for these chemoattractants.	rottlerin	191-200	C-X-C motif chemokine ligand 8	Homo sapiens	253-257
18677938-1	2008	UNLABELLED: The aim of our study was to characterize the priming effect of extracellular nucleotides on reactive oxygen species (ROS) production induced by formyl-methionyl-leucyl-phenylalanine (fMLP), interleukin-8 (IL-8), leukotriene B4 (LTB4), and platelet activating factor (PAF).	Reactive Oxygen Species	104-127	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
18677938-1	2008	UNLABELLED: The aim of our study was to characterize the priming effect of extracellular nucleotides on reactive oxygen species (ROS) production induced by formyl-methionyl-leucyl-phenylalanine (fMLP), interleukin-8 (IL-8), leukotriene B4 (LTB4), and platelet activating factor (PAF).	Reactive Oxygen Species	129-132	C-X-C motif chemokine ligand 8	Homo sapiens	202-215
18677938-1	2008	UNLABELLED: The aim of our study was to characterize the priming effect of extracellular nucleotides on reactive oxygen species (ROS) production induced by formyl-methionyl-leucyl-phenylalanine (fMLP), interleukin-8 (IL-8), leukotriene B4 (LTB4), and platelet activating factor (PAF).	Reactive Oxygen Species	129-132	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
18677938-9	2008	GF 109203X (5 microM), an inhibitor of all neutrophil"s PKC isoforms, or RO 31-8220 (5uM), an inhibitor of classical and novel PKC isoforms, abolished the responses induced by fMLP (10 nM) IL-8 (10 nM), LTB4 (100 nM) or PAF (100 nM).	bisindolylmaleimide I	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
18677938-11	2008	Rottlerin (5 microM), a PKC delta inhibitor, almost abolished the effect of fMLP in the absence or in the presence of UTP, indicating that PKC delta is essential for the fMLP-induced effect; rottlerin also caused inhibition of ROS production induced by IL-8, LTB4 or PAF, however the priming effect of UTP was not affected for these chemoattractants.	rottlerin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	253-257
17471497-1	2007	We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs) by activating the ERK1/2 and p38 kinase pathways.	Deferoxamine	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
17996682-4	2007	We thus examined the independent contributions of the bovine-human-discrepant amino acids within CXCL8 to the biological activity of bG31P.	bg31p	133-138	C-X-C motif chemokine ligand 8	Homo sapiens	97-102
17996682-5	2007	We first examined the effect of wholesale ligation of the carboxy half of hCXCL8 onto the amino half of bG31P, and found that this human-bovine chaemeric G31P (hbG31P; i.e., bCXCL8((3-44))K11R/G31P-hCXCL8((45-72))) fully retained the ELR-CXC chemokine antagonist activity of bG31P.	bg31p	161-166	C-X-C motif chemokine ligand 8	Homo sapiens	74-80
17996682-6	2007	Thus, hbG31P blocked the abilities of human CXCL8 to chemoattract human neutrophil or induce reactive oxygen intermediate (ROI) release.	reactive oxygen	93-108	C-X-C motif chemokine ligand 8	Homo sapiens	44-49
17471497-0	2007	Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2- and p38 kinase-dependent activation of AP-1.	Iron	38-42	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
17471497-2	2007	In this study we investigated the mechanisms involved in IL-8 generation by DFO, focusing on the transcription factors involved and the roles of both mitogen-activated protein kinases (MAPKs) in the transcription factor activation.	Deferoxamine	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
17471497-1	2007	We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs) by activating the ERK1/2 and p38 kinase pathways.	Iron	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
17471497-9	2007	In summary, our results indicate that iron chelator-induced IL-8 generation in IECs involves activation of ERK1/2 and p38 kinase and downstream activation of AP-1.	Iron	38-42	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
17471497-1	2007	We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs) by activating the ERK1/2 and p38 kinase pathways.	Deferoxamine	48-60	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
18032608-7	2007	We found that pretreatment with muramyl dipeptide (MDP), a ligand for Nod2, significantly decreased production of the proinflammatory cytokines TNF-alpha, IL-8, and IL-1beta upon Nod2, TLR4, and TLR2 restimulation in primary human monocyte-derived macrophages from a large cohort of individuals.	Acetylmuramyl-Alanyl-Isoglutamine	32-49	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
17928431-5	2007	Ten times more of the synthetic structures with four to six d-alanine-substituted polyglycerophosphate units (50 nM) than of the native LTA preparation was required to induce IL-8 release.	dalbergioidin	60-69	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
18071264-6	2007	LR inhibited the PMA plus A23187-induced increase in IL-6, IL-8, and TNF-alpha expression in HMC-1 cells.	Calcimycin	26-32	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
17928431-5	2007	Ten times more of the synthetic structures with four to six d-alanine-substituted polyglycerophosphate units (50 nM) than of the native LTA preparation was required to induce IL-8 release.	polyglycerophosphate	82-102	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
18045955-11	2007	High levels of CXCL8, CXCL1, and CXCL3 accounted for a shorter relapse-free survival of ERalpha-positive patients treated with tamoxifen.	Tamoxifen	127-136	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
17455223-2	2007	Our recent study showed that ghrelin could stimulate protein kinase C-mediated activation of nuclear factor-kappaB (NF-kappaB) and interleukin-8 secretion in human colonic epithelial cells transfected with a functional ghrelin receptor.	Ghrelin	29-36	C-X-C motif chemokine ligand 8	Homo sapiens	131-144
17961179-0	2007	Heparin-induced thrombocytopenia associated with interleukin-8-dependent platelet activation in a patient with antiphospholipid syndrome.	Heparin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	49-62
17961179-3	2007	Further analysis revealed anti-interleukin (IL)-8 antibodies and IL-8-dependent platelet activation facilitated by heparin, which may explain this unusual case of heparin-induced thrombocytopenia.	Heparin	115-122	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
17961179-3	2007	Further analysis revealed anti-interleukin (IL)-8 antibodies and IL-8-dependent platelet activation facilitated by heparin, which may explain this unusual case of heparin-induced thrombocytopenia.	Heparin	163-170	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
17922819-11	2007	At 72 h the trilayer severely restricted transfer of sodium fluorescein (NaF) (ten-fold reduction) whilst transfer of a 4 kDa FITC-conjugated dextran was virtually occluded, confirming a restrictive barrier.	Fluorescein	53-71	C-X-C motif chemokine ligand 8	Homo sapiens	73-76
17908789-0	2007	Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets.	Gold	49-51	C-X-C motif chemokine ligand 8	Homo sapiens	68-81
18085018-3	2007	The most prominent effect of macrolides noted in vitro is the inhibition of pro-inflammatory cytokines such as interleukin-8.	Macrolides	29-39	C-X-C motif chemokine ligand 8	Homo sapiens	111-124
17923111-5	2007	Moreover, LPA1 and LPA3 siRNA also inhibited LPA-enhanced IL-1-dependent long-term IL-8 and MCP-1 mRNA expression, and subsequent THP-1 cell chemotaxis toward LPA-treated HUVEC-conditioned media.	lysophosphatidic acid	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
17720209-11	2007	Preincubation with intracellular calcium chelator (BAPTA-AM) attenuated IL-1beta and IL-8 production, but not GM-CSF and LIF production.	Calcium	33-40	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
17720209-11	2007	Preincubation with intracellular calcium chelator (BAPTA-AM) attenuated IL-1beta and IL-8 production, but not GM-CSF and LIF production.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
17720209-13	2007	Our results also suggest that PM(10) induces the production of pro-inflammatory mediators via either intracellular calcium-dependent (IL-1beta, IL-8) or -independent (GM-CSF, LIF) pathways.	Calcium	115-122	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
17923111-5	2007	Moreover, LPA1 and LPA3 siRNA also inhibited LPA-enhanced IL-1-dependent long-term IL-8 and MCP-1 mRNA expression, and subsequent THP-1 cell chemotaxis toward LPA-treated HUVEC-conditioned media.	lysophosphatidic acid	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
18039378-12	2007	BES released the inflammatory mediators IL-8, PGE2 and LTB4 constitutively and following exposure to LPS.	BES	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
17897621-5	2007	In contrast, the STS-induced ATP increase was prevented by any of three inhibitors of the glycolytic pathway: 2-deoxyglucose, iodoacetamide, and NaF.	Adenosine Triphosphate	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	145-148
18039378-13	2007	Interestingly, LPS induced a higher release of IL-8, but not PGE2 and LTB4 in COPD BES (p &lt; 0.001) which correlated with lung function changes.	BES	83-86	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
17643414-6	2007	In addition, flavone was found to reduce the lipopolysaccharide (LPS)-induced interleukin (IL)-8 production in pulmonary epithelial cells, which was confirmed by transcription analysis.	flavone	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	78-96
17533374-9	2007	Finally, inhibition of IL-8 signaling potentiated etoposide-induced cell death in hypoxic PC3 cells.	Etoposide	50-59	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
17977560-2	2007	Butein significantly inhibited TNF-alpha-induced interleukin 8 (IL-8) secretion and mRNA expression.	butein	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	49-62
17977560-2	2007	Butein significantly inhibited TNF-alpha-induced interleukin 8 (IL-8) secretion and mRNA expression.	butein	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
18323243-1	2007	The interactions in free radicals processes between cyclosporine A (CsA) and sodium fluoride (NaF) on in vitro model human placental mitochondria were evaluated.	Sodium Fluoride	77-92	C-X-C motif chemokine ligand 8	Homo sapiens	94-97
17720876-6	2007	A 5-10% dilution of FLDE stimulated a significant release of IL-6 and IL-8 at 6-24 h in a PKC-dependent manner vs. control medium-treated cells.	flde	20-24	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
17600310-5	2007	By gas chromatography/mass spectrometry (GC/MS) we show that acrolein and crotonaldehyde, two alpha,beta-unsaturated aldehydes, are contained in aqueous cigarette smoke extract (CSE) at micromolar concentrations and mimic CSE in evoking the release of the neutrophil chemoattractant IL-8 and of the pleiotropic inflammatory cytokine TNF-alpha from the human macrophagic cell line U937.	Acrolein	61-69	C-X-C motif chemokine ligand 8	Homo sapiens	283-287
17600310-5	2007	By gas chromatography/mass spectrometry (GC/MS) we show that acrolein and crotonaldehyde, two alpha,beta-unsaturated aldehydes, are contained in aqueous cigarette smoke extract (CSE) at micromolar concentrations and mimic CSE in evoking the release of the neutrophil chemoattractant IL-8 and of the pleiotropic inflammatory cytokine TNF-alpha from the human macrophagic cell line U937.	2-butenal	74-88	C-X-C motif chemokine ligand 8	Homo sapiens	283-287
17600310-6	2007	In addition, acrolein (10-30 microM) released IL-8 also from cultured human alveolar macrophages and THP-1 macrophagic cells.	Acrolein	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
17600310-7	2007	4-hydroxy-2-nonenal (30-100 microM), an endogenous alpha,beta-unsaturated aldehyde that is abundant in lungs of patients with COPD, stimulated the release of IL-8 from U937 cells, whereas the saturated aldehyde, acetaldehyde, was ineffective.	4-hydroxy-2-nonenal	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
17600310-7	2007	4-hydroxy-2-nonenal (30-100 microM), an endogenous alpha,beta-unsaturated aldehyde that is abundant in lungs of patients with COPD, stimulated the release of IL-8 from U937 cells, whereas the saturated aldehyde, acetaldehyde, was ineffective.	alpha,beta-unsaturated aldehyde	51-82	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
17600310-7	2007	4-hydroxy-2-nonenal (30-100 microM), an endogenous alpha,beta-unsaturated aldehyde that is abundant in lungs of patients with COPD, stimulated the release of IL-8 from U937 cells, whereas the saturated aldehyde, acetaldehyde, was ineffective.	Aldehydes	74-82	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
17600310-7	2007	4-hydroxy-2-nonenal (30-100 microM), an endogenous alpha,beta-unsaturated aldehyde that is abundant in lungs of patients with COPD, stimulated the release of IL-8 from U937 cells, whereas the saturated aldehyde, acetaldehyde, was ineffective.	Acetaldehyde	212-224	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
17600310-8	2007	CSE-evoked IL-8 release was remarkably (&gt; 80%) inhibited by N-acetyl-cysteine (0.1-3 mM) or glutathione monoethyl ester (1-3 mM).	Acetylcysteine	63-80	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
17600310-8	2007	CSE-evoked IL-8 release was remarkably (&gt; 80%) inhibited by N-acetyl-cysteine (0.1-3 mM) or glutathione monoethyl ester (1-3 mM).	S-ethyl glutathione	95-122	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
17720876-9	2007	However, the PKCepsilon inhibitor, Ro 31-8220, effectively inhibited FLDE-stimulated IL-8 and IL-6 release.	Ro 31-8220	35-45	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
17720876-9	2007	However, the PKCepsilon inhibitor, Ro 31-8220, effectively inhibited FLDE-stimulated IL-8 and IL-6 release.	flde	69-73	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
17720876-10	2007	Inhibition of FLDE-stimulated IL-6 and IL-8 was confirmed in a dominant-negative PKCepsilon-expressing BEAS-2B cell line but not observed in a PKCalpha dominant negative BEAS-2B cell line.	flde	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
17720876-11	2007	These data support the hypothesis that FLDE exposure stimulates bronchial epithelial IL-8 and IL-6 release via a PKCepsilon-dependent pathway.	flde	39-43	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
17891168-10	2007	The anti-inflammatory glucocorticoid, dexamethasone, inhibited the histamine enhanced NF-kappaB-dependent transcription and IL-6 and IL-8 release.	Dexamethasone	38-51	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
17916596-10	2007	TNF-alpha-induced up-regulation of IL-8 via nuclear factor-kappaB in CAFs is an inflammatory pathway, potentially permissive for cancer invasion that may represent a novel therapeutic target.	cafs	69-73	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
18201443-7	2007	RESULTS: In primary HSNEC, IL-8 mRNA levels decreased dose dependently in the range of 10-50 microM of AC with an eightfold decrease at 50 microM.	Acrolein	103-105	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
18201443-10	2007	However, differentiated HSNEC showed a marginal decrease in a dose-dependent manner for both IL-8 and HBD-2 within the range of 10-50 microM of AC.	Acrolein	144-146	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
17891168-7	2007	The H(1) receptor antagonist, mepyramine, caused a rightward shift in the concentration-response curves of TNFalpha-induced NF-kappaB-dependent transcription (pA(2)=9.91) and release of IL-6 (pA(2)=8.78) and IL-8 (pA(2)=8.99).	Pyrilamine	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
17891168-10	2007	The anti-inflammatory glucocorticoid, dexamethasone, inhibited the histamine enhanced NF-kappaB-dependent transcription and IL-6 and IL-8 release.	Histamine	67-76	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
17761353-7	2007	Taken together, these results suggest that HPE-induced IL-8 secretion occurs via activation of JNK/SAPK and transcription factors NF-kappaB and AP-1 in PMA-differentiated THP-1 cells.	1-(3-Methoxy-4-hydroxyphenyl)-2-[2-hydroxy-3-methoxy-5-[4-(3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane-8-yl]phenyl]-3-hydroxy-1-propanone	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
17767946-5	2007	Removal of gas phase and a portion of the particle phase hydrocarbons with the denuder decreased the interleukin-8 (IL-8) secretion to unexposed levels.	Hydrocarbons	57-69	C-X-C motif chemokine ligand 8	Homo sapiens	101-114
17767946-5	2007	Removal of gas phase and a portion of the particle phase hydrocarbons with the denuder decreased the interleukin-8 (IL-8) secretion to unexposed levels.	Hydrocarbons	57-69	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
17877767-9	2007	CONCLUSION: Differential effects on MC cytokine inhibition were observed, with epinastine inhibiting MC secretion of IL-5, IL-8, IL-10 and conjunctival neutrophil infiltration.	epinastine	79-89	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
17959901-4	2007	Stimulation of gingival fibroblasts with tumor necrosis factor-alpha, IL-1alpha, and lipopolysaccharide markedly induced IL-8 production, and the IL-8 production was synergistically augmented in the presence of or pre-treatment with histamine.	Histamine	233-242	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
17959901-6	2007	These results indicate that histamine induces IL-8 production from gingival fibroblasts through H1R, and synergistically augments the inflammatory stimuli by amplification of the MAPK and NF-kappaB through H1R-linked PLC.	Histamine	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
17947704-4	2007	In this study, we demonstrate that 17beta-estradiol (E2) attenuates LPS-induced expression of CXCL8 in human peripheral blood monocytes.	Estradiol	35-51	C-X-C motif chemokine ligand 8	Homo sapiens	94-99
17684042-5	2007	fMLF, IL-8, leukotriene B(4), or platelet-activating factor stimulation resulted in an initial increase in VASP Ser 157 phosphorylation, which was maximal by 30 s and was followed by a return to baseline Ser 157 phosphorylation by 10 min.	Serine	112-115	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
17684042-5	2007	fMLF, IL-8, leukotriene B(4), or platelet-activating factor stimulation resulted in an initial increase in VASP Ser 157 phosphorylation, which was maximal by 30 s and was followed by a return to baseline Ser 157 phosphorylation by 10 min.	Serine	204-207	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
17947704-5	2007	Treatment of monocytes with estradiol before administration of LPS reduces CXCL8 message and protein production through an estrogen receptor-dependent mechanism, and luciferase reporter assays demonstrate that this inhibition is mediated transcriptionally.	Estradiol	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	75-80
17805211-0	2007	Butyrate regulates the expression of pathogen-triggered IL-8 in intestinal epithelia.	Butyrates	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
17639599-13	2007	High glucose-induced IL-8 production by microglia may contribute to diabetic encephalopathy.	Glucose	5-12	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
18035981-10	2007	This fact indicates that the chemokine pathway of IL-8 activity could be modulated by this treatment, most likely by polycyclic aromatic hydrocarbons.	Polycyclic Aromatic Hydrocarbons	117-149	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
17639599-4	2007	Therefore, we investigated whether high glucose could activate microglia and stimulate IL-8 secretion and if so, the possible mechanisms that were involved.	Glucose	40-47	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
17639599-5	2007	ELISA results showed that treatment with high glucose (35 mM) compared with treatment with low glucose (10 mM) time-dependently elevated secretion of GRO (the rat ortholog of human IL-8) in primary cultured rat microglia.	Glucose	46-53	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
17639599-5	2007	ELISA results showed that treatment with high glucose (35 mM) compared with treatment with low glucose (10 mM) time-dependently elevated secretion of GRO (the rat ortholog of human IL-8) in primary cultured rat microglia.	Glucose	95-102	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
17805211-6	2007	Butyrate transiently down-regulated expression of IL-8 stimulated by Pam3CSK4.	Butyrates	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
17805211-7	2007	Treatment of cells with butyrate before Pam3CSK4, however, enhanced production of IL-8.	Butyrates	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
17964516-11	2007	Using the area under the dose response curve (AUC(0 to 24) h), thalidomide reduced the AUC for IL-6 by 56%, for IL-8 by 30%, and TNF-alpha by 32%.	Thalidomide	63-74	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
17707346-0	2007	Modulation of early growth response gene 1 and interleukin-8 expression by ribotoxin deoxynivalenol (vomitoxin) via ERK1/2 in human epithelial intestine 407 cells.	deoxynivalenol	85-99	C-X-C motif chemokine ligand 8	Homo sapiens	47-60
17726017-0	2007	Role of the Jak/STAT pathway in the regulation of interleukin-8 transcription by oxidized phospholipids in vitro and in atherosclerosis in vivo.	Phospholipids	90-103	C-X-C motif chemokine ligand 8	Homo sapiens	50-63
17726017-1	2007	Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC) and its component phospholipid, 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine, induce endothelial cells (EC) to synthesize chemotactic factors, such as interleukin 8 (IL-8).	1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	9-66	C-X-C motif chemokine ligand 8	Homo sapiens	245-258
17726017-1	2007	Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC) and its component phospholipid, 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine, induce endothelial cells (EC) to synthesize chemotactic factors, such as interleukin 8 (IL-8).	1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	9-66	C-X-C motif chemokine ligand 8	Homo sapiens	260-264
17707346-0	2007	Modulation of early growth response gene 1 and interleukin-8 expression by ribotoxin deoxynivalenol (vomitoxin) via ERK1/2 in human epithelial intestine 407 cells.	deoxynivalenol	101-110	C-X-C motif chemokine ligand 8	Homo sapiens	47-60
17707346-2	2007	The purpose of this study was to test the hypothesis that ribotoxin DON evokes the epithelial sentinel signals which contributes to the pro-inflammatory cytokine interleukin-8 in human epithelial cells.	ribotoxin	58-67	C-X-C motif chemokine ligand 8	Homo sapiens	162-175
17707346-4	2007	Particularly, ribotoxin DON markedly elevated the phosphorylated extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) mitogen-activated protein kinase (MAPK) which mediated DON-induced interleukin-8 (IL-8) production.	DONS	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	196-209
17707346-4	2007	Particularly, ribotoxin DON markedly elevated the phosphorylated extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) mitogen-activated protein kinase (MAPK) which mediated DON-induced interleukin-8 (IL-8) production.	DONS	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	211-215
17707346-5	2007	DON-activated ERK1/2 also mediated the production of early growth response gene 1 (EGR-1) in the epithelial cell line and EGR-1 had the positive regulatory effect on the interleukin-8 production in the human epithelial cells.	DONS	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	170-183
17883254-2	2007	Caco-2 cells were pretreated with amino acids (1, 2, and 5 mM) for 2 h and then stimulated with 1 mM H 2O 2 for 6 h. The secretion of IL-8, a proinflammatory mediator, was determined by ELISA as an indicator of tissue oxidative stress.	Hydrogen Peroxide	101-107	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
17949493-2	2007	The method involves the complexation of Al, Ti and Fe with excess EDTA and the selective de-complexation of TiO-EDTA and Al-EDTA complexes with tartaric acid and NaF respectively.	tio-edta	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	162-165
17949493-2	2007	The method involves the complexation of Al, Ti and Fe with excess EDTA and the selective de-complexation of TiO-EDTA and Al-EDTA complexes with tartaric acid and NaF respectively.	al-edta	121-128	C-X-C motif chemokine ligand 8	Homo sapiens	162-165
17883254-3	2007	The inhibition of H 2O 2-induced IL-8 secretion from Caco-2 cells was observed by pretreatment with Cys, Val, Ile, Leu, Trp, His, Lys, and Ala.	Hydrogen Peroxide	18-24	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
17883254-3	2007	The inhibition of H 2O 2-induced IL-8 secretion from Caco-2 cells was observed by pretreatment with Cys, Val, Ile, Leu, Trp, His, Lys, and Ala.	Cysteine	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
17883254-3	2007	The inhibition of H 2O 2-induced IL-8 secretion from Caco-2 cells was observed by pretreatment with Cys, Val, Ile, Leu, Trp, His, Lys, and Ala.	Valine	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
17883254-3	2007	The inhibition of H 2O 2-induced IL-8 secretion from Caco-2 cells was observed by pretreatment with Cys, Val, Ile, Leu, Trp, His, Lys, and Ala.	Isoleucine	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
17883254-3	2007	The inhibition of H 2O 2-induced IL-8 secretion from Caco-2 cells was observed by pretreatment with Cys, Val, Ile, Leu, Trp, His, Lys, and Ala.	Leucine	115-118	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
17883254-3	2007	The inhibition of H 2O 2-induced IL-8 secretion from Caco-2 cells was observed by pretreatment with Cys, Val, Ile, Leu, Trp, His, Lys, and Ala.	Tryptophan	120-123	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
17883254-3	2007	The inhibition of H 2O 2-induced IL-8 secretion from Caco-2 cells was observed by pretreatment with Cys, Val, Ile, Leu, Trp, His, Lys, and Ala.	Histidine	125-128	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
17883254-3	2007	The inhibition of H 2O 2-induced IL-8 secretion from Caco-2 cells was observed by pretreatment with Cys, Val, Ile, Leu, Trp, His, Lys, and Ala.	Lysine	130-133	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
17883254-3	2007	The inhibition of H 2O 2-induced IL-8 secretion from Caco-2 cells was observed by pretreatment with Cys, Val, Ile, Leu, Trp, His, Lys, and Ala.	Alanine	139-142	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
17631613-4	2007	Costimulation of 16HBE14o- human bronchial epithelial cells and primary mucociliary-differentiated tracheal epithelial cells with RV and TNF-alpha induced synergistic increases in IL-8 and epithelial neutrophil attractant-78 production.	16hbe14o	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
17880076-4	2007	Ranked by their propensity to orient interfacial water molecules, sodium salts could be placed in the following order: NaSCN &gt; NaClO4 &gt; NaI &gt; NaNO3 approximately NaBr &gt; NaCl &gt; pure water approximately NaF approximately Na2SO4.	sodium salts	66-78	C-X-C motif chemokine ligand 8	Homo sapiens	216-219
17683978-17	2007	The results from a partial least-square regression analysis predicted that both PAHs and a group of metals including Fe and Mn contributed to IL-6 and IL-8 induction.	Iron	117-119	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
17726017-1	2007	Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC) and its component phospholipid, 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine, induce endothelial cells (EC) to synthesize chemotactic factors, such as interleukin 8 (IL-8).	Phospholipids	95-107	C-X-C motif chemokine ligand 8	Homo sapiens	245-258
17726017-1	2007	Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC) and its component phospholipid, 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine, induce endothelial cells (EC) to synthesize chemotactic factors, such as interleukin 8 (IL-8).	Phospholipids	95-107	C-X-C motif chemokine ligand 8	Homo sapiens	260-264
17726017-1	2007	Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC) and its component phospholipid, 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine, induce endothelial cells (EC) to synthesize chemotactic factors, such as interleukin 8 (IL-8).	1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine	109-170	C-X-C motif chemokine ligand 8	Homo sapiens	245-258
17726017-1	2007	Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC) and its component phospholipid, 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine, induce endothelial cells (EC) to synthesize chemotactic factors, such as interleukin 8 (IL-8).	1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine	109-170	C-X-C motif chemokine ligand 8	Homo sapiens	260-264
17917246-0	2007	Glycated human serum albumin induces interleukin 8 mRNA expression through reactive oxygen species and NADPH oxidase-dependent pathway in monocyte-derived U937 cells.	Reactive Oxygen Species	75-98	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
17141246-3	2007	The objectives of this study were to examine the influence of PPAR gamma and its agonist (rosiglitazone) on the TNFalpha, IL-6, IL-8 and IL-10 gene expression in monocytes of patients with diabetic macroangiopathy and to analyse obtained results in context of selected atherogenic factors ant direct indicators of endothelial lesion.	Rosiglitazone	90-103	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
17141246-6	2007	Following rosiglitazone therapy, a statistically significant downward tendency of TNFalpha (p=0.026) and IL-8 (p=0.008) gene expression was noted.	Rosiglitazone	10-23	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
17917246-3	2007	As a result, IL-8 mRNA expression in U-937 cells was time- and dose-dependently enhanced by stimulation with Glc-HSA and GA-HSA.	glc-hsa	109-116	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
17928716-1	2007	Candida albicans, Saccharomyces cerevisiae and their cell wall components, zymosan and glucan, have been shown to stimulate interleukin-8 (IL-8/CXCL-8) production by intestinal epithelial cell-like Caco-2 cells pre-cultured with 10 mM butyric acid.	Zymosan	75-82	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
17928716-1	2007	Candida albicans, Saccharomyces cerevisiae and their cell wall components, zymosan and glucan, have been shown to stimulate interleukin-8 (IL-8/CXCL-8) production by intestinal epithelial cell-like Caco-2 cells pre-cultured with 10 mM butyric acid.	Glucans	87-93	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
17928716-1	2007	Candida albicans, Saccharomyces cerevisiae and their cell wall components, zymosan and glucan, have been shown to stimulate interleukin-8 (IL-8/CXCL-8) production by intestinal epithelial cell-like Caco-2 cells pre-cultured with 10 mM butyric acid.	Butyric Acid	235-247	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
17917246-3	2007	As a result, IL-8 mRNA expression in U-937 cells was time- and dose-dependently enhanced by stimulation with Glc-HSA and GA-HSA.	ga-hsa	121-127	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
17917246-4	2007	Furthermore, promoter activity of the IL-8 reporter gene was enhanced approximately 2-fold by stimulation with Glc-HSA and GA-HSA.	Glucose	111-114	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
17917246-4	2007	Furthermore, promoter activity of the IL-8 reporter gene was enhanced approximately 2-fold by stimulation with Glc-HSA and GA-HSA.	ga-hsa	123-129	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
17917246-6	2007	IL-8 mRNA expression was suppressed by NAC and apocynin but not calphostin in cells stimulated with Glc-HSA; however, its expression in cells stimulated with GA-HSA was suppressed by calphostin but not NAC.	ga-hsa	158-164	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
17711515-3	2007	Neutrophils from SCD individuals showed an inhibition of spontaneous apoptosis when cultured in vitro, in the presence of autologous serum for 20 h. Intracellular cyclic adenosine monophosphate (cAMP) levels were approximately twofold increased in SCD neutrophils; possible cAMP-upregulating factors present in SCD serum include interleukin-8, granulocyte-macrophage colony-stimulating factor and prostaglandin.	Cyclic AMP	163-193	C-X-C motif chemokine ligand 8	Homo sapiens	329-342
17711515-3	2007	Neutrophils from SCD individuals showed an inhibition of spontaneous apoptosis when cultured in vitro, in the presence of autologous serum for 20 h. Intracellular cyclic adenosine monophosphate (cAMP) levels were approximately twofold increased in SCD neutrophils; possible cAMP-upregulating factors present in SCD serum include interleukin-8, granulocyte-macrophage colony-stimulating factor and prostaglandin.	Cyclic AMP	195-199	C-X-C motif chemokine ligand 8	Homo sapiens	329-342
17917246-7	2007	These results indicated that IL-8 mRNA expression was upregulated by NFkappaB and AP-1 in U937 cells stimulated with Glc-HSA and GA-HSA, but the signaling pathways were different.	glc-hsa	117-124	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
17917246-7	2007	These results indicated that IL-8 mRNA expression was upregulated by NFkappaB and AP-1 in U937 cells stimulated with Glc-HSA and GA-HSA, but the signaling pathways were different.	ga-hsa	129-135	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
17760719-11	2007	We confirmed that capsaicin inhibited IL-8 mRNA expression after infection of gastric epithelial cells with H. pylori for 6 hours.	Capsaicin	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
17711487-2	2007	To investigate this, we studied the effect of two glucocorticoids (dexamethasone and triamcinolone acetonide) on reducing lipopolysaccharide (LPS)- and tumour necrosis factor (TNF)-alpha-induced interleukin (IL)-8 release in a monocytic cell line and two lymphocytic cell lines (HUT-78 and Jurkat).	Triamcinolone Acetonide	85-108	C-X-C motif chemokine ligand 8	Homo sapiens	195-213
17711487-3	2007	The effect of the histone deacetylase inhibitor trichostatin A (TSA) on LPS- and TNF-alpha-induced IL-8 release and its repression by glucocorticoids was also examined.	trichostatin A	48-62	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
17711487-3	2007	The effect of the histone deacetylase inhibitor trichostatin A (TSA) on LPS- and TNF-alpha-induced IL-8 release and its repression by glucocorticoids was also examined.	trichostatin A	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
17711487-4	2007	LPS and TNF-alpha induced IL-8 release in all three cell lines and this induction was inhibited by both dexamethasone and triamcinolone.	Dexamethasone	104-117	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
17711487-4	2007	LPS and TNF-alpha induced IL-8 release in all three cell lines and this induction was inhibited by both dexamethasone and triamcinolone.	Triamcinolone	122-135	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
17711487-5	2007	Pretreatment of cells with TSA enhanced basal and LPS- and TNFalpha-stimulated IL-8 release in all three cell lines.	trichostatin A	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
17711487-6	2007	TSA also attenuated the inhibitory effect of glucocorticoids on stimulated IL-8 release.	trichostatin A	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
17711487-7	2007	Chromatin immunoprecipitation assays confirmed that LPS and TNF-alpha enhanced histone acetylation at the IL-8 promoter and that this was inhibited by triamcinolone in all three cell types.	Triamcinolone	151-164	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
17662277-7	2007	Lower levels of IL-10 and IL-8 were found in quiet stage uveitis (surgical) samples compared with active uveitis (diagnostic) samples and in samples of patients treated with methotrexate (MTX) compared with samples of patients not treated with MTX.	Methotrexate	174-186	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
17662277-7	2007	Lower levels of IL-10 and IL-8 were found in quiet stage uveitis (surgical) samples compared with active uveitis (diagnostic) samples and in samples of patients treated with methotrexate (MTX) compared with samples of patients not treated with MTX.	Methotrexate	188-191	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
17513150-6	2007	Although IGF-I stimulated the phosphorylation of both Akt (protein kinase B) and extracellular-regulated kinase (ERK), the effect of IGF-I at IL-8 expression was inhibited only by U0126, a pharmacological inhibitor of MAPK/ERK kinase (MEK) and not by inhibition of the upstream activator of Akt, phosphatidylinositol-3 kinase (PI3K).	U 0126	180-185	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
17680813-5	2007	Co-incubation of SCD neutrophils with KT5720 (an inhibitor of PKA) abrogated increased basal SCD neutrophil adhesion, spontaneous chemotaxis and IL-8-stimulated chemotaxis.	KT 5720	38-44	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
17680813-6	2007	Stimulation of SCD neutrophils with IL-8 also significantly augmented SCD neutrophil adhesion to FN with a concomitant increase in cAMP levels and this increase in adhesion was abolished by KT5720.	Cyclic AMP	131-135	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
17760719-3	2007	Herein, we demonstrated that capsaicin inhibited the release of pro-inflammatory cytokine, interleukin-8 (IL-8) by H. pylori-infected gastric epithelial cells through nuclear factor-kappaB (NF-kappaB) signal pathway.	Capsaicin	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
17760719-6	2007	We measured IL-8 mRNA transcripts in H. pylori-infected gastric epithelial cells co-treated with capsaicin by reverse transcriptase-polymerase chain reaction analysis.	Capsaicin	97-106	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
17760719-9	2007	RESULTS: Capsaicin inhibits H. pylori-induced IL-8 production by gastric epithelial cells in dose- and time-dependent manner.	Capsaicin	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
17760719-10	2007	Capsaicin as low as 100 micromol/L significantly inhibited IL-8 production in H. pylori-infected MKN45 cells (43.2% of control) at 24 hours incubation, whereas inhibited IL-8 production in H. pylori-infected AGS cells (70% of control).	Capsaicin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
17760719-10	2007	Capsaicin as low as 100 micromol/L significantly inhibited IL-8 production in H. pylori-infected MKN45 cells (43.2% of control) at 24 hours incubation, whereas inhibited IL-8 production in H. pylori-infected AGS cells (70% of control).	Capsaicin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
17760719-14	2007	CONCLUSIONS: Nontoxic dose of capsaicin inhibited H. pylori-induced IL-8 production by gastric epithelial cells through the modulation of IkappaB-, NF-kappaB-, and IL-8 pathways.	Capsaicin	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
17760719-14	2007	CONCLUSIONS: Nontoxic dose of capsaicin inhibited H. pylori-induced IL-8 production by gastric epithelial cells through the modulation of IkappaB-, NF-kappaB-, and IL-8 pathways.	Capsaicin	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
17760719-15	2007	We conclude that capsaicin can be proposed as a potential anti-inflammatory drug by inhibition of the production of IL-8 in H. pylori-infected gastric epithelium.	Capsaicin	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
18026701-7	2007	RESULTS: Glucosamine significantly suppressed the IL-1beta-induced IL-8 production as well as its mRNA expression (p &lt; 0.05) at 1 mM.	Glucosamine	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
18026701-10	2007	CONCLUSIONS: These observations suggest that glucosamine can suppress the IL-1beta-mediated activation of synoviocytes (such as IL-8-, nitric oxide- and PGE(2)-production, and phosphorylation of p38 MAPK), thereby possibly exhibiting antiinflammatory actions in arthritis.	Glucosamine	45-56	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
17532154-4	2007	Marinosomes contributed to reduce inflammation induced by croton oil by regulating PGE2 and IL-8 production in human keratinocyte cultures.	marinosomes	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
17920466-4	2007	Phagocytosis of the polyethylene particles or retrieved polyethylene particles by differentiated U937 cells stimulated the release of cytokines including interleukin 1beta, interleukin 6, interleukin 8, and vascular endothelial growth factor.	Polyethylene	20-32	C-X-C motif chemokine ligand 8	Homo sapiens	188-201
17786306-12	2007	Cepharanthin inhibited the production of IR-induced IL-6 and IL-8, which are downstream targets of NF-kappaB.	cepharanthine	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
17920466-4	2007	Phagocytosis of the polyethylene particles or retrieved polyethylene particles by differentiated U937 cells stimulated the release of cytokines including interleukin 1beta, interleukin 6, interleukin 8, and vascular endothelial growth factor.	Polyethylene	56-68	C-X-C motif chemokine ligand 8	Homo sapiens	188-201
17920466-5	2007	Microarray analysis revealed that the expression of IL8, CCL4, CXCR4, and some other genes was up-regulated after contact with retrieved polyethylene particles.	Polyethylene	137-149	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
17932597-4	2007	METHODS: The effects of the LABAs salmeterol and formoterol on the synthesis of soluble interleukin-8 (IL-8), granulocyte-macrophage colony-stimulating factor (GM-CSF), and vascular endothelial growth factor (VEGF) in the human airway epithelial cell line A549 was investigated in vitro.	Salmeterol Xinafoate	34-44	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
17932597-4	2007	METHODS: The effects of the LABAs salmeterol and formoterol on the synthesis of soluble interleukin-8 (IL-8), granulocyte-macrophage colony-stimulating factor (GM-CSF), and vascular endothelial growth factor (VEGF) in the human airway epithelial cell line A549 was investigated in vitro.	Formoterol Fumarate	49-59	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
17932597-6	2007	RESULTS: Both salmeterol and formoterol significantly suppressed IL-8, GM-CSF, and VEGF secretion from tumor necrosis factor-alpha-stimulated A549 cells.	Salmeterol Xinafoate	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
17932597-6	2007	RESULTS: Both salmeterol and formoterol significantly suppressed IL-8, GM-CSF, and VEGF secretion from tumor necrosis factor-alpha-stimulated A549 cells.	Formoterol Fumarate	29-39	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
17932597-7	2007	Results indicated that formoterol was more potent than salmeterol in suppressing IL-8 and VEGF production.	Formoterol Fumarate	23-33	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
17932597-7	2007	Results indicated that formoterol was more potent than salmeterol in suppressing IL-8 and VEGF production.	Salmeterol Xinafoate	55-65	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
17884996-6	2007	Finally, IL-8 production of LPS-stimulated human pulmonary epithelial cells could be significantly reduced by these flavonoids.	Flavonoids	116-126	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
18090004-3	2007	To elucidate the mechanisms underlying the immunosuppressive effects of ethanol, we investigated whether ethanol pretreatment may influence the changes in adhesion molecule expression induced by lipopolysaccharide (LPS) or interleukin (IL)-8 in human whole blood.	Ethanol	105-112	C-X-C motif chemokine ligand 8	Homo sapiens	223-241
18090004-10	2007	Stimulation with IL-8 significantly upregulated CD11b expression (5.3 +/- 1.7 to 7.5 +/- 2.7, p &lt; 0.01) and this IL-8-induced upregulation of CD11b was also inhibited by ethanol pretreatment (p &lt; 0.001).	Ethanol	173-180	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
18090004-10	2007	Stimulation with IL-8 significantly upregulated CD11b expression (5.3 +/- 1.7 to 7.5 +/- 2.7, p &lt; 0.01) and this IL-8-induced upregulation of CD11b was also inhibited by ethanol pretreatment (p &lt; 0.001).	Ethanol	173-180	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
17667842-3	2007	We studied the effect of azithromycin (AZM) on the suppression of NF-kappaB activation and the synthesis of pro-inflammatory cytokines IL-6 and IL-8 by TA cells obtained from premature infants.	Azithromycin	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
17700564-7	2007	Moreover, IL-33-mediated IL-8 production by HUCBMCs was markedly reduced by the p38 MAPK inhibitor, SB203580.	hucbmcs	44-51	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
17700564-7	2007	Moreover, IL-33-mediated IL-8 production by HUCBMCs was markedly reduced by the p38 MAPK inhibitor, SB203580.	SB 203580	100-108	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
17667842-3	2007	We studied the effect of azithromycin (AZM) on the suppression of NF-kappaB activation and the synthesis of pro-inflammatory cytokines IL-6 and IL-8 by TA cells obtained from premature infants.	Azithromycin	39-42	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
17667842-8	2007	AZM significantly reduced the IL-6 and IL-8 production to the levels similar to control.	Azithromycin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
18050667-3	2007	Tubes containing NaF in addition to EDTA, usually used for measurement of plasma glucose and HbA1c in diabetic patients, could be used for the collection of plasma sample.	Glucose	81-88	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
17636245-0	2007	Transcriptional regulation of deoxynivalenol-induced IL-8 expression in human monocytes.	deoxynivalenol	30-44	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
17636245-7	2007	Consistent with reporter studies, the NF-kappaB inhibitor caffeic acid phenethyl ester completely ablated both DON-induced IL-8 mRNA and protein expression.	caffeic acid phenethyl ester	58-86	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
17636245-7	2007	Consistent with reporter studies, the NF-kappaB inhibitor caffeic acid phenethyl ester completely ablated both DON-induced IL-8 mRNA and protein expression.	deoxynivalenol	111-114	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
17636245-10	2007	Taken together, these data suggest that DON-induced IL-8 expression is likely to be mediated at the transcriptional level by NF-kappaB, specifically p65, but does not appear to involve mRNA stabilization.	deoxynivalenol	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
17636246-3	2007	In this work, we showed that NiSO(4) induced the expression of HLA-DR, CD83, CD86, and CD40 and the production of interleukin (IL)-8, IL-6, and IL-12p40 in human DCs, whereas DNCB induced mainly the expression of CD83 and CD86 and the production of IL-8.	niso	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	249-253
17631879-0	2007	Combination of fluticasone propionate and salmeterol potentiates the suppression of cigarette smoke-induced IL-8 production by macrophages.	Fluticasone	15-37	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
17631879-0	2007	Combination of fluticasone propionate and salmeterol potentiates the suppression of cigarette smoke-induced IL-8 production by macrophages.	Salmeterol Xinafoate	42-52	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
17631879-4	2007	The aim of this study was to determine whether combined fluticasone propionate, a corticosteroid, and salmeterol, a long-acting beta(2)-adrenoceptor agonist, can suppress IL-8 production by human macrophages.	Fluticasone	56-78	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
17631879-4	2007	The aim of this study was to determine whether combined fluticasone propionate, a corticosteroid, and salmeterol, a long-acting beta(2)-adrenoceptor agonist, can suppress IL-8 production by human macrophages.	Salmeterol Xinafoate	102-112	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
17407152-5	2007	After 24 h, the early effect of TCDD on adipocytes was predominantly on inflammation, particularly induction of COX-2 and KC (IL-8), which is accompanied by upregulation of C/EBPbeta and delta.	Polychlorinated Dibenzodioxins	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
17631879-7	2007	IL-8 release by cigarette smoke was significantly suppressed in a concentration-dependent manner by fluticasone and salmeterol.	Fluticasone	100-111	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
17631879-7	2007	IL-8 release by cigarette smoke was significantly suppressed in a concentration-dependent manner by fluticasone and salmeterol.	Salmeterol Xinafoate	116-126	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
17631879-9	2007	Interestingly, preincubation of cells with suboptimal concentration of salmeterol for 4 h before fluticasone administration for 30 min potentiates the inhibitory effect of fluticasone on IL-8 release.	Salmeterol Xinafoate	71-81	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
17631879-9	2007	Interestingly, preincubation of cells with suboptimal concentration of salmeterol for 4 h before fluticasone administration for 30 min potentiates the inhibitory effect of fluticasone on IL-8 release.	Fluticasone	172-183	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
17785828-2	2007	After priming with IFN-gamma and stimulation with NadADelta351-405, mo-DCs strongly up-regulated maturation markers CD83, CD86, CD80, and HLA-DR, secreted moderate quantities of TNF-alpha, IL-6, and IL-8, and produced a slight, although significant, amount of IL-12p70.	nadadelta351	50-62	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
17513351-1	2007	The importance of intramolecular disulfides in a noncovalent dimeric protein interleukin-8 (IL-8) has been studied by replacing cysteines in each of the two disulfide pairs with alpha-aminobutyric acid (CH(2)-SH --&gt; CH(2)-CH(3)).	Disulfides	33-43	C-X-C motif chemokine ligand 8	Homo sapiens	77-90
17513351-1	2007	The importance of intramolecular disulfides in a noncovalent dimeric protein interleukin-8 (IL-8) has been studied by replacing cysteines in each of the two disulfide pairs with alpha-aminobutyric acid (CH(2)-SH --&gt; CH(2)-CH(3)).	Disulfides	33-43	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
17513351-1	2007	The importance of intramolecular disulfides in a noncovalent dimeric protein interleukin-8 (IL-8) has been studied by replacing cysteines in each of the two disulfide pairs with alpha-aminobutyric acid (CH(2)-SH --&gt; CH(2)-CH(3)).	Cysteine	128-137	C-X-C motif chemokine ligand 8	Homo sapiens	77-90
17513351-1	2007	The importance of intramolecular disulfides in a noncovalent dimeric protein interleukin-8 (IL-8) has been studied by replacing cysteines in each of the two disulfide pairs with alpha-aminobutyric acid (CH(2)-SH --&gt; CH(2)-CH(3)).	Cysteine	128-137	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
17513351-1	2007	The importance of intramolecular disulfides in a noncovalent dimeric protein interleukin-8 (IL-8) has been studied by replacing cysteines in each of the two disulfide pairs with alpha-aminobutyric acid (CH(2)-SH --&gt; CH(2)-CH(3)).	Disulfides	33-42	C-X-C motif chemokine ligand 8	Homo sapiens	77-90
17513351-1	2007	The importance of intramolecular disulfides in a noncovalent dimeric protein interleukin-8 (IL-8) has been studied by replacing cysteines in each of the two disulfide pairs with alpha-aminobutyric acid (CH(2)-SH --&gt; CH(2)-CH(3)).	Disulfides	33-42	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
17513351-6	2007	Deleting either disulfide in IL-8 results in substantial loss in receptor activity, indicating that both disulfides are critical for function in the folded protein.	Disulfides	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
17513351-6	2007	Deleting either disulfide in IL-8 results in substantial loss in receptor activity, indicating that both disulfides are critical for function in the folded protein.	Disulfides	105-115	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
17678632-5	2007	Pretreatment of human intestinal epithelial HT-29 cells with TMMC also significantly inhibited the IL-8 and extracellular matrix metalloproteinase-7 levels induced by TNF-alpha.	2',4',6'-tris(methoxymethoxy) chalcone	61-65	C-X-C motif chemokine ligand 8	Homo sapiens	99-148
18078616-1	2007	OBJECTIVES: Recent studies demonstrated in vivo the effectiveness of statins in reducing the inflammatory response in rheumatic diseases, and still more recently, simvastatin has been reported to inhibit in vitro IL-6 and IL-8 production by unstimulated fibroblast-like-synoviocytes (FLS) from rheumatoid arthritis (RA) patients.	Simvastatin	163-174	C-X-C motif chemokine ligand 8	Homo sapiens	222-226
17850672-0	2007	Differential regulation of iron chelator-induced IL-8 synthesis via MAP kinase and NF-kappaB in immortalized and malignant oral keratinocytes.	Iron	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
17850672-2	2007	In the present study, we examined the expression and mechanism of IL-8 in which it is involved by treating immortalized (IHOK) and malignant human oral keratinocytes (HN12) cells with deferoxamine (DFO).	Deferoxamine	184-196	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
17850672-2	2007	In the present study, we examined the expression and mechanism of IL-8 in which it is involved by treating immortalized (IHOK) and malignant human oral keratinocytes (HN12) cells with deferoxamine (DFO).	Deferoxamine	198-201	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
17850672-6	2007	RESULTS: IHOK cells incubated with DFO showed increased expression of IL-8 mRNA, as well as higher release of the IL-8 protein.	Deferoxamine	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
17850672-6	2007	RESULTS: IHOK cells incubated with DFO showed increased expression of IL-8 mRNA, as well as higher release of the IL-8 protein.	Deferoxamine	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
17850672-7	2007	The up-regulation of DFO-induced IL-8 expression was higher in IHOK cells than in HN12 cells and was concentration-dependent.	Deferoxamine	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
17850672-8	2007	DFO acted additively with IL-1beta to strongly up-regulate IL-8 in IHOK cells but not in HN12 cells.	Deferoxamine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
17850672-9	2007	Accordingly, selective p38 and ERK1/2 inhibitors for both kinases abolished DFO-induced IL-8 expression in both IHOK and HN12 cells.	Deferoxamine	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
17850672-11	2007	The IL-8 inducing effects of DFO were mediated by a nitric oxide donor (S-nitrosoglutathione), and by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB, as well as by wortmannin, which inhibits the phosphatidylinositol 3-kinase-dependent activation of NAD(P)H oxidase.	Deferoxamine	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
17850672-11	2007	The IL-8 inducing effects of DFO were mediated by a nitric oxide donor (S-nitrosoglutathione), and by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB, as well as by wortmannin, which inhibits the phosphatidylinositol 3-kinase-dependent activation of NAD(P)H oxidase.	Nitric Oxide	52-64	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
17850672-11	2007	The IL-8 inducing effects of DFO were mediated by a nitric oxide donor (S-nitrosoglutathione), and by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB, as well as by wortmannin, which inhibits the phosphatidylinositol 3-kinase-dependent activation of NAD(P)H oxidase.	S-Nitrosoglutathione	74-92	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
17850672-11	2007	The IL-8 inducing effects of DFO were mediated by a nitric oxide donor (S-nitrosoglutathione), and by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB, as well as by wortmannin, which inhibits the phosphatidylinositol 3-kinase-dependent activation of NAD(P)H oxidase.	pyrrolidine dithiocarbamic acid	102-129	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
17850672-11	2007	The IL-8 inducing effects of DFO were mediated by a nitric oxide donor (S-nitrosoglutathione), and by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB, as well as by wortmannin, which inhibits the phosphatidylinositol 3-kinase-dependent activation of NAD(P)H oxidase.	Wortmannin	172-182	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
17850672-12	2007	CONCLUSION: This results demonstrate that DFO-induced IL-8 acts via multiple signaling pathways in immortalized and malignant oral keratinocytes, and that the control of IL-8 may be an important target for immunotheraphy against human oral premalignant lesions.	Deferoxamine	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
17850672-12	2007	CONCLUSION: This results demonstrate that DFO-induced IL-8 acts via multiple signaling pathways in immortalized and malignant oral keratinocytes, and that the control of IL-8 may be an important target for immunotheraphy against human oral premalignant lesions.	Deferoxamine	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
18219763-6	2007	IL-17 binding to an IL-17 receptor expressed on epithelial, endothelial, and fibroblastic stromal cells triggers the activation of transcription factor NF-kappaB and mitogen-activated protein kinase (p-38), which in turn results in the secretion of IL-1, TNF-alpha, IL-6, IL-8, or prostaglandin E2.	Dinoprostone	281-297	C-X-C motif chemokine ligand 8	Homo sapiens	272-276
18078616-7	2007	Simvastatin significantly inhibited (about 20%) IL-6 and IL-8 production from IL-1-stimulated FLS.	Simvastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
18078616-10	2007	CONCLUSION: Simvastatin significantly inhibits the production of IL-6 and IL-8 also in IL-1-stimulated FLS, even though to a lesser extent than in unstimulated cells, via a HMG-CoA-reductase block with an interference in prenylation process and NF-kB activation.	Simvastatin	12-23	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
17470570-4	2007	We hypothesized that exercise-induced nitric oxide (NO) production is an important signaling event for IL-6, IL-8, HO-1, and HSP72 expression in muscle.	Nitric Oxide	38-50	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
17470570-7	2007	L-NAME caused marked reductions in exercise-induced expression of 4 of 11 mRNAs including IL-6, IL-8, and HO-1.	NG-Nitroarginine Methyl Ester	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
17449633-7	2007	LPS and the proinflammatory cytokines TNF-alpha, IL1beta, IFN-gamma, and sodium butyrate stimulation increased IL31, IL31Ralpha, and OSMR mRNA expression, while IL31 itself enhanced IL8 expression in IEC.	Butyric Acid	73-88	C-X-C motif chemokine ligand 8	Homo sapiens	182-185
17671691-6	2007	All examined pancreatic carcinoma cells expressed CXCL-8 and TNFRII mRNA constitutively in RPMI-1640 medium without FBS.	rpmi-1640 medium	91-107	C-X-C motif chemokine ligand 8	Homo sapiens	50-56
17680645-0	2007	Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes.	Palmitic Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
17680645-8	2007	Importantly, palmitic acid was found to induce significantly elevated levels of biologically active neutrophil chemoattractant, IL-8, from steatotic hepatocytes.	Palmitic Acid	13-26	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
17680645-9	2007	Incubation of the cells with palmitate led to increased IL-8 gene expression and secretion (both mRNA and protein) through mechanisms involving activation of nuclear factor kappaB (NF-kappaB) and c-Jun N-terminal kinase/activator protein-1.	Palmitates	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
17671691-8	2007	Actinomycin D suppressed and cycloheximide augmented CXCL-8 mRNA which was induced by TNF-alpha or not.	Cycloheximide	29-42	C-X-C motif chemokine ligand 8	Homo sapiens	53-59
17629956-6	2007	And, inhibitors of NF-kappaB (caffeic acid phenylethyl ester), p38 (SB 203580), or ERK1/2 (PD 98059) significantly reduced IL-8 induction by the organism.	caffeic acid phenethyl ester	30-60	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
17495961-6	2007	Furthermore, incubation with DMF before stimulation with IL-1beta resulted in a significant decrease in NF-kappaB binding to the IL-8 kappaB and the IL-20 kappaB-binding sites as well as a subsequent decrease in IL-8 and IL-20 mRNA expression.	Dimethyl Fumarate	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
17628646-8	2007	Dexamethasone treatment of BECs only partially suppressed IP-10 and TNF-alpha but was more effective at suppressing RANTES, IL-6, and IL-8.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
18193101-10	2007	Treatment with a proton pump inhibitor, lansoprazole reduces the mucosal levels of IL-8 mRNA and protein in GERD, including RE and NERD.	Lansoprazole	40-52	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
17876544-10	2007	Inhibitors for ERK (PD98059 and U0216) and p38 MAPK (SB203580) significantly reduced the IL-17F-induced IL-6, IL-8, LIF, MMP-1, and MMP-3 secretion.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
17876544-10	2007	Inhibitors for ERK (PD98059 and U0216) and p38 MAPK (SB203580) significantly reduced the IL-17F-induced IL-6, IL-8, LIF, MMP-1, and MMP-3 secretion.	u0216	32-37	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
17876544-10	2007	Inhibitors for ERK (PD98059 and U0216) and p38 MAPK (SB203580) significantly reduced the IL-17F-induced IL-6, IL-8, LIF, MMP-1, and MMP-3 secretion.	SB 203580	53-61	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
17495961-6	2007	Furthermore, incubation with DMF before stimulation with IL-1beta resulted in a significant decrease in NF-kappaB binding to the IL-8 kappaB and the IL-20 kappaB-binding sites as well as a subsequent decrease in IL-8 and IL-20 mRNA expression.	Dimethyl Fumarate	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	212-216
17697714-1	2007	This study concerns effects on water-borne lead from combinations of chlorine (CL) or chloramines (CA) with fluosilicic acid (FSA) or sodium fluoride (NaF).	Water	31-36	C-X-C motif chemokine ligand 8	Homo sapiens	151-154
17216397-2	2007	The main objectives were: (1) to evaluate the effect of diode laser-NaF varnish combination on binding fluoride to dental enamel in an in vitro model and (2) to analyse outer enamel surface changes produced by the laser energy.	Fluorides	103-111	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
17446059-6	2007	EGCG significantly inhibited the IL-1beta+Abeta (25-35)-induced IL-6, IL-8, vascular endothelial growth factor (VEGF) and prostaglandin (PG)E(2) production at 24 h (P&lt;.01).	epigallocatechin gallate	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
17446059-6	2007	EGCG significantly inhibited the IL-1beta+Abeta (25-35)-induced IL-6, IL-8, vascular endothelial growth factor (VEGF) and prostaglandin (PG)E(2) production at 24 h (P&lt;.01).	UNII-042A8N37WH	42-47	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
17446059-7	2007	The maximal inhibition rate of IL-6, IL-8, VEGF and PGE(2) production by EGCG was approximately 54.40%, 56.01%, 69.06% and 47.03%, respectively.	epigallocatechin gallate	73-77	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
17876051-8	2007	Kaempferol suppressed the expression of proinflammatory cytokine interleukin-6 and chemokines interleukin-8, monocyte chemoattractant protein-1, and regulated on activation, normal T-cell expressed and secreted.	kaempferol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	94-107
17519305-12	2007	Simvastatin therapy significantly inhibited lipopolysaccharide-activated monocyte release of O(2)(-) (P &lt; 0.0005), IL-8 (P &lt; 0.03), and TNF (P &lt; 0.02).	Simvastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
17558435-0	2007	Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells.	virodhamine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
17558435-0	2007	Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells.	1(4H)-Pyridinepropanoic acid, 3-hydroxy-2-methyl-4-oxo-, ethyl ester	16-20	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
17558435-13	2007	In the absence of agonist, SR144528 by itself reduced TNF-alpha induced IL-8 release.	SR 144528	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
18048020-4	2007	CNTO2424 down-regulates poly(I:C)-induced production of IL-6, IL-8, MCP-1, RANTES, and IP-10 in human lung epithelial cells.	poly	24-28	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
18048020-4	2007	CNTO2424 down-regulates poly(I:C)-induced production of IL-6, IL-8, MCP-1, RANTES, and IP-10 in human lung epithelial cells.	Carbon	0-1	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
17604003-12	2007	The decrease of IL-8 secretion from IEC was more pronounced after pre-incubation with 13-Oxo-ODE compared to the PPARgamma agonist troglitazone and higher as with the known PPARgamma ligands 13-HODE and 15-HETE.	13-oxo-9,11-octadecadienoic acid	86-96	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
17604003-12	2007	The decrease of IL-8 secretion from IEC was more pronounced after pre-incubation with 13-Oxo-ODE compared to the PPARgamma agonist troglitazone and higher as with the known PPARgamma ligands 13-HODE and 15-HETE.	Troglitazone	131-143	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
17604003-12	2007	The decrease of IL-8 secretion from IEC was more pronounced after pre-incubation with 13-Oxo-ODE compared to the PPARgamma agonist troglitazone and higher as with the known PPARgamma ligands 13-HODE and 15-HETE.	13-hydroxy-9,11-octadecadienoic acid	191-198	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
17604003-12	2007	The decrease of IL-8 secretion from IEC was more pronounced after pre-incubation with 13-Oxo-ODE compared to the PPARgamma agonist troglitazone and higher as with the known PPARgamma ligands 13-HODE and 15-HETE.	15-hydroxy-5,8,11,13-eicosatetraenoic acid	203-210	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
17667496-10	2007	Elevated plasma levels of IL-6, IL-8, complement C3a, and IL-1ra as well as expression of CD11b, L- and P-selectin, and platelet-leukocyte aggregates were significantly attenuated by systemic lidocaine.	Lidocaine	192-201	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
17517880-11	2007	Interestingly, TcdB-treated HMC-1 cells, but not latrunculin B-treated HMC-1 cells, showed a strong p38 MAPK-dependent increase in interleukin-8 release.	trimethylaminocarboxyldihydroboran	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	131-144
17504902-0	2007	Metformin suppresses interleukin (IL)-1beta-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells.	Metformin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
17504902-5	2007	RESULTS: Metformin dose-dependently suppressed IL-1beta-induced IL-8 production, cAMP-induced mRNA expression and aromatase activity, and 5-bromo-2"-deoxyuridine incorporation in ESCs.	Metformin	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
17442054-3	2007	Pre-treatment of immortalized HBMEC with atorvastatin (50 nmol/L to 1 micromol/L) dose-dependently prevented an inflammatory up-regulation of monocyte chemoattractant protein-1/CCL2 but not of interleukin-8/CXCL8 and intercellular adhesion molecule-1 expression by tumor necrosis factor-alpha or interleukin-1beta.	Atorvastatin	41-53	C-X-C motif chemokine ligand 8	Homo sapiens	193-206
17442054-3	2007	Pre-treatment of immortalized HBMEC with atorvastatin (50 nmol/L to 1 micromol/L) dose-dependently prevented an inflammatory up-regulation of monocyte chemoattractant protein-1/CCL2 but not of interleukin-8/CXCL8 and intercellular adhesion molecule-1 expression by tumor necrosis factor-alpha or interleukin-1beta.	Atorvastatin	41-53	C-X-C motif chemokine ligand 8	Homo sapiens	207-212
17496166-5	2007	Sch527123 inhibited neutrophil chemotaxis and myeloperoxidase release in response to CXCL1 and CXCL8 but had no effect on the response of these cells to C5a or formyl-methionyl-leucyl-phenylalanine.	2-hydroxy-N,N-dimethyl-3-(2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-enylamino)benzamide	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	95-100
17433832-10	2007	LPS-stimulated IL-6, TNF-alpha, PGE(2) and PGF(2alpha) release was significantly suppressed by treatment with all concentrations of SB202190, whereas ILS-stimulated IL-1beta release was only significantly inhibited in the presence of 50 microM SB202190 and there was no effect of SB202190 on LPS-stimulated IL-8 release.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	132-140	C-X-C motif chemokine ligand 8	Homo sapiens	307-311
17488804-8	2007	The mechanism of caffeine seems to involve the inhibition of the extracellular signal-regulated kinase 1/2 (ERK1/2), p38, and Akt, leading to a marked decrease in adenosine-induced HIF-1alpha accumulation, VEGF transcriptional activation, and VEGF and IL-8 protein accumulation.	Caffeine	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	252-256
17488804-8	2007	The mechanism of caffeine seems to involve the inhibition of the extracellular signal-regulated kinase 1/2 (ERK1/2), p38, and Akt, leading to a marked decrease in adenosine-induced HIF-1alpha accumulation, VEGF transcriptional activation, and VEGF and IL-8 protein accumulation.	Adenosine	163-172	C-X-C motif chemokine ligand 8	Homo sapiens	252-256
17488804-11	2007	These data provide evidence that adenosine could modulate the migration of colon cancer cells by an HIF-1alpha/VEGF/IL-8-dependent mechanism and that caffeine has the potential to inhibit colon cancer cell growth.	Adenosine	33-42	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
17488804-0	2007	Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells.	Caffeine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	125-138
17488804-0	2007	Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells.	Adenosine	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	125-138
17488804-7	2007	Pretreatment of cells with caffeine significantly reduces adenosine-induced VEGF promoter activity and VEGF and IL-8 expression.	Caffeine	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
17504764-4	2007	Mutagenesis and biochemical analyses revealed that (a) the integrity of the detergent-resistant membranes is necessary for dl-CD40 homodimer formation, (b) the cytoplasmic Cys(238) of CD40 is the target for the de novo disulfide oxidation induced by receptor oligomerization, and (c) dl-CD40 homodimer formation is required for CD40-induced interleukin-8 secretion.	Cysteine	172-175	C-X-C motif chemokine ligand 8	Homo sapiens	341-354
17608466-0	2007	Synthesis and biological evaluation of N-pyrazolyl-N"-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis.	-pyrazolyl	40-50	C-X-C motif chemokine ligand 8	Homo sapiens	116-129
17608466-0	2007	Synthesis and biological evaluation of N-pyrazolyl-N"-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis.	Nitrogen	51-53	C-X-C motif chemokine ligand 8	Homo sapiens	116-129
17608466-2	2007	We report here the synthesis of a new N-(4-substituted)pyrazolyl-N"-alkyl/benzyl/phenylureas that are potent inhibitors of interleukin-8 (IL8)-induced neutrophil chemotaxis.	n-(4-substituted)pyrazolyl	38-64	C-X-C motif chemokine ligand 8	Homo sapiens	123-136
17608466-2	2007	We report here the synthesis of a new N-(4-substituted)pyrazolyl-N"-alkyl/benzyl/phenylureas that are potent inhibitors of interleukin-8 (IL8)-induced neutrophil chemotaxis.	n-(4-substituted)pyrazolyl	38-64	C-X-C motif chemokine ligand 8	Homo sapiens	138-141
17608466-3	2007	The first series of compounds, obtained by functionalization with a urea moiety of the 5-amino-1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carboxylic acid ethyl ester 3, blocked the IL8-induced neutrophil chemotaxis, while they did not block N-formylmethionylleucylphenylalanine-mediated chemotaxis.	Urea	68-72	C-X-C motif chemokine ligand 8	Homo sapiens	180-183
17608466-3	2007	The first series of compounds, obtained by functionalization with a urea moiety of the 5-amino-1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carboxylic acid ethyl ester 3, blocked the IL8-induced neutrophil chemotaxis, while they did not block N-formylmethionylleucylphenylalanine-mediated chemotaxis.	5-amino-1-(2-hydroxy-2-phenylethyl)-1h-pyrazole-4-carboxylic acid ethyl ester	87-164	C-X-C motif chemokine ligand 8	Homo sapiens	180-183
17638896-8	2007	IL8-S cells expressed 2- to 3-fold higher levels of phospho-EGFR, src, Akt, and nuclear factor kappaB (NF-kappaB) and showed increased survival when treated with docetaxel.	Docetaxel	162-171	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
17599375-0	2007	Endocytosis, oxidative stress and IL-8 expression in human lung epithelial cells upon treatment with fine and ultrafine TiO2: role of the specific surface area and of surface methylation of the particles.	titanium dioxide	120-124	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
17491020-2	2007	The alpha,beta-unsaturated aldehydes in cigarette smoke (acrolein and crotonaldehyde) inhibited production of interleukin-2 (IL-2), IL-10, granulocyte-macrophage colony-stimulating factor, interferon-gamma, and tumor necrosis factor-alpha by human T cells but did not inhibit production of IL-8.	2-butenal	70-84	C-X-C motif chemokine ligand 8	Homo sapiens	290-294
26110364-8	2007	Fibroblasts are also stimulated by DDHAM to secrete key proinflammatory(IL-1 and IL-6) and chemotactic cytokines or chemokines (proand IL-8) involved in regulating and enhancing wound repair processes.	ddham	35-40	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
17491020-2	2007	The alpha,beta-unsaturated aldehydes in cigarette smoke (acrolein and crotonaldehyde) inhibited production of interleukin-2 (IL-2), IL-10, granulocyte-macrophage colony-stimulating factor, interferon-gamma, and tumor necrosis factor-alpha by human T cells but did not inhibit production of IL-8.	alpha,beta-unsaturated aldehydes	4-36	C-X-C motif chemokine ligand 8	Homo sapiens	290-294
17491020-2	2007	The alpha,beta-unsaturated aldehydes in cigarette smoke (acrolein and crotonaldehyde) inhibited production of interleukin-2 (IL-2), IL-10, granulocyte-macrophage colony-stimulating factor, interferon-gamma, and tumor necrosis factor-alpha by human T cells but did not inhibit production of IL-8.	Acrolein	57-65	C-X-C motif chemokine ligand 8	Homo sapiens	290-294
17592301-12	2007	The PRBC group had a significantly different expression profile compared with the others and included up-regulation of the interleukin-8, toll-like receptor 4, cryropyrin, prostaglandin-endoperoxide synthase-2, and heparinase genes.	prbc	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	123-158
17584482-9	2007	This study showed that application of ZBUF is more effective to decrease the level of inflammatory mediators including TNF-alpha, IL-6, and IL-8 than administration of MP after pediatric CPB.	zbuf	38-42	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
17560458-11	2007	Culture supernatants from MCs and PMNs of TB patients contained increased amounts of IL-8 and TNFalpha.	mcs	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
17588396-8	2007	Methylprednisolone attenuated postoperative tumor necrosis factor-alpha, interleukin 6, interleukin 8, and C-reactive protein levels while increasing interleukin 10 release.	Methylprednisolone	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
17581316-0	2007	Induction of urokinase-type plasminogen activator, interleukin-8 and early growth response-1 by STI571 through activating mitogen activated protein kinase in human small cell lung cancer cells.	Imatinib Mesylate	96-102	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
17466485-0	2007	Simvastatin and fluvastatin reduce interleukin-6 and interleukin-8 lipopolysaccharide (LPS) stimulated production by isolated human monocytes from chronic kidney disease patients.	Simvastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	53-66
17466485-0	2007	Simvastatin and fluvastatin reduce interleukin-6 and interleukin-8 lipopolysaccharide (LPS) stimulated production by isolated human monocytes from chronic kidney disease patients.	Fluvastatin	16-27	C-X-C motif chemokine ligand 8	Homo sapiens	53-66
17581316-1	2007	We previously demonstrated the simultaneous induction of urokinase-type plasminogen activator and interleukin-8, a CXC chemokine, in doxorubicin-treated human NCI-H69 small cell lung cancer cells in which extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase might be involved.	Doxorubicin	133-144	C-X-C motif chemokine ligand 8	Homo sapiens	98-111
17581316-3	2007	We therefore investigated the effects of STI571 on the expression of urokinase-type plasminogen activator and interleukin-8 in NCI-H69 cells.	Imatinib Mesylate	41-47	C-X-C motif chemokine ligand 8	Homo sapiens	110-123
17581316-6	2007	U0126, an inhibitor against extracellular signal-regulated kinase 1/2, however, only inhibited the STI571-induced interleukin-8 accumulation.	U 0126	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	114-127
17581316-6	2007	U0126, an inhibitor against extracellular signal-regulated kinase 1/2, however, only inhibited the STI571-induced interleukin-8 accumulation.	Imatinib Mesylate	99-105	C-X-C motif chemokine ligand 8	Homo sapiens	114-127
17317104-2	2007	Previously we found that TNF-alpha-induced reactive oxygen species (ROS) production is required for NF-kappaB action because antioxidants inhibited TNF-alpha-inducible IL-8 expression without affecting its nuclear translocation.	Reactive Oxygen Species	43-66	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
17317104-2	2007	Previously we found that TNF-alpha-induced reactive oxygen species (ROS) production is required for NF-kappaB action because antioxidants inhibited TNF-alpha-inducible IL-8 expression without affecting its nuclear translocation.	Reactive Oxygen Species	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
17317104-12	2007	These results indicate that the ROS-mediated TNF-alpha-induced IL-8 transcription is regulated by NF-kappaB/RelA phosphorylation at the critical Ser(276) residue by PKAc, resulting in stable enhanceosome formation on target genes.	Reactive Oxygen Species	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
17550933-8	2007	CONCLUSIONS: Rapid withdrawal of inhaled corticosteroids results in an exacerbation of asthma that is preceded by an increase in sputum neutrophils and IL-8 concentrations, in contrast to an increase in eosinophils reported in previous studies in which inhaled steroids are slowly tapered.	Steroids	48-56	C-X-C motif chemokine ligand 8	Homo sapiens	152-156
17317104-12	2007	These results indicate that the ROS-mediated TNF-alpha-induced IL-8 transcription is regulated by NF-kappaB/RelA phosphorylation at the critical Ser(276) residue by PKAc, resulting in stable enhanceosome formation on target genes.	Serine	145-148	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
17112620-8	2007	1,25-Dihydroxyvitamin D(3) was able to down-regulate the expression of TNF-alpha, IL-6, IL-1, and IL-8, confirming its immunomodulatory properties.	Calcitriol	0-26	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
17403059-6	2007	Inhibition by TGF-beta1 was negated by SB-431542, a small molecule inhibitor that specifically blocks the kinase activity of the type I TGF-beta receptor (ALK5) In contrast to lactoferrin release, another important neutrophil function, interleukin (IL)-8 driven chemotaxis, was not affected by TGF-beta1 at 1 pg/ml or 100 pg/ml.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	39-48	C-X-C motif chemokine ligand 8	Homo sapiens	236-254
17888208-2	2007	In this study we evaluate whether simvastatin could influence the production of pro-inflammatory cytokines (interleukin (IL)-6 and IL-8) and nitric oxide (NO) by activated human chondrocytes.	Simvastatin	34-45	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
17888208-5	2007	RESULTS: Simvastatin demonstrated significant dose-dependent inhibition of IL-6 and IL-8 production of isolated chondrocytes and cartilage explants up to 99% for IL-6 and up to 88% for IL-8 (p &lt; 0.01).	Simvastatin	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
17888208-5	2007	RESULTS: Simvastatin demonstrated significant dose-dependent inhibition of IL-6 and IL-8 production of isolated chondrocytes and cartilage explants up to 99% for IL-6 and up to 88% for IL-8 (p &lt; 0.01).	Simvastatin	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
17666914-6	2007	The expression of intracellular cell adhesion molecule (ICAM)-1, monocyte chemoattractant protein (MCP)-1, and interleukin (IL)-8 were attenuated by curcumin at both mRNA and protein level.	Curcumin	149-157	C-X-C motif chemokine ligand 8	Homo sapiens	111-129
17609508-4	2007	In addition, PVAE attenuated phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-6, and IL-8 secretion in human mast cells.	pvae	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
17609508-4	2007	In addition, PVAE attenuated phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-6, and IL-8 secretion in human mast cells.	Calcium	71-78	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
17609508-4	2007	In addition, PVAE attenuated phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-6, and IL-8 secretion in human mast cells.	Calcimycin	89-95	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
17880760-7	2007	IL-8 EBC levels decreased after antibiotic treatment (T0 0.36+/-0.03pg/ml vs T1 0.28+/-0.03pg/ml; p=0.03) and pH values increased (T0 7.36+/-0.09 vs T1 7.61+/-0.08; p=0.04).	NSC638702	5-8	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
18409814-5	2007	Nickel contact at very low concentrations (10(-5), 10(-6) M) induced upregulation of MMP-2 and IL-8 mRNA production; chromium contact at very low concentrations killed all cells.	Nickel	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
18409824-2	2007	We assessed urinary excretion of 1-naphthol (1-NAF), biomarker of naphthalene exposure, in non-occupationally exposed subjects.	1-naphthol	33-43	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
18409824-5	2007	Median concentration of 1-NAF was 6-fold higher in smokers compared to nonsmokers (respectively, 7.7 microg/g creatinine vs 1.3 microg/g creatinine).	Creatinine	110-120	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
18409824-5	2007	Median concentration of 1-NAF was 6-fold higher in smokers compared to nonsmokers (respectively, 7.7 microg/g creatinine vs 1.3 microg/g creatinine).	Creatinine	137-147	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
17880760-1	2007	Interleukin (IL)-8 is a major factor in inflammatory response and the IL-8 levels in exhaled breath condensate (EBC) may be used as a marker of airway inflammation.	NSC638702	112-115	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
17596547-3	2007	One of these involves addition of glycolysis inhibitors, such as sodium fluoride-potassium oxalate (NaF-KOx) to sample collection tubes, whereas the other requires immediate refrigeration and sample separation.	sodium fluoride potassium oxalate	65-98	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
17579020-4	2007	The rODNs promoted the survival of macrophages and were able to activate IL-8 secretion through a chloroquine-resistant pathway.	Chloroquine	98-109	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
17040605-8	2007	Our results showed that IL-5, IL-6 and IL-8 in both the AR and NAR groups were strikingly elevated in comparison with the control group (all p &lt; 0.01 for AR group; p &lt; 0.05, 0.05, 0.01, respectively, for NAR group); and they were even higher in the AR group than those in the NAR group (p &lt; 0.01, 0.05, 0.01, respectively).	Argon	56-58	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
17040605-8	2007	Our results showed that IL-5, IL-6 and IL-8 in both the AR and NAR groups were strikingly elevated in comparison with the control group (all p &lt; 0.01 for AR group; p &lt; 0.05, 0.05, 0.01, respectively, for NAR group); and they were even higher in the AR group than those in the NAR group (p &lt; 0.01, 0.05, 0.01, respectively).	Argon	64-66	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
17544805-3	2007	In this study we confirmed that NO regulates cytokine and chemokine release by resting MDM: accumulation of TNF-alpha, IL-12, IL-10, CCL5 (RANTES) and CXCL8 (IL-8) in MDM supernatants was significantly modified by the NO-donor S-nitroso-N-penicillamine (SNAP).	s-nitroso-n-penicillamine	227-252	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
18958735-0	2007	Palladium attenuates the pro-inflammatory interactions of C5a, interleukin-8 and pneumolysin with human neutrophils.	Palladium	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
17552048-4	2007	RESULTS: Infliximab plus MTX treatment resulted in more rapid decreases in levels of matrix metalloproteinase-3 (MMP-3), intercellular cell adhesion molecule-1, interleukin 8 (IL-8), and tumor necrosis factor-a than treatment with MTX alone.	Methotrexate	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	161-174
17552048-4	2007	RESULTS: Infliximab plus MTX treatment resulted in more rapid decreases in levels of matrix metalloproteinase-3 (MMP-3), intercellular cell adhesion molecule-1, interleukin 8 (IL-8), and tumor necrosis factor-a than treatment with MTX alone.	Methotrexate	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
17552048-6	2007	An increase in IL-8 levels from baseline to Week 54 correlated with worsening in vdHSS at Week 54 in the MTX-alone group.	Methotrexate	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
17552048-9	2007	MMP-3 levels at different timepoints were consistently associated with clinical improvements at Week 54 in the infliximab plus MTX group, while increases in IL-8 levels correlated with a worsening in vdHSS at Week 54 in the MTX-alone group.	Methotrexate	224-227	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
17606477-3	2007	Administration of recombinant human IL-8 induced a rapid, time-dependent increase in cyclin D1 expression in AIPC cells, a response attenuated by the translation inhibitor cycloheximide but not by the RNA synthesis inhibitor, actinomycin D.	Cycloheximide	172-185	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
17606477-6	2007	LY294002 and rapamycin each abrogated the IL-8-promoted phosphorylation of rS6 and attenuated the rate of AIPC cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
17544805-3	2007	In this study we confirmed that NO regulates cytokine and chemokine release by resting MDM: accumulation of TNF-alpha, IL-12, IL-10, CCL5 (RANTES) and CXCL8 (IL-8) in MDM supernatants was significantly modified by the NO-donor S-nitroso-N-penicillamine (SNAP).	snap	254-258	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
17606477-7	2007	Our results indicate that IL-8 signaling (a) regulates cyclin D1 expression at the level of translation, (b) regulates the activation of proteins associated with the translation of capped and 5"-oligopyrimidine tract transcripts, and (c) activates signal transduction pathways underpinning AIPC cell proliferation.	oligopyrimidine	195-210	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
17290398-9	2007	Subcutaneous injection or oral administration of parthenolide showed significant tumor growth inhibition in the xenograft model via decreased production of interleukin-8 (IL-8) or vascular endothelial growth factor (VEGF).	parthenolide	49-61	C-X-C motif chemokine ligand 8	Homo sapiens	156-169
17483743-5	2007	Among the PDF groups, IL-8 secretions from ECs and PMNs were lower with 100 and 1000 micromol/L Arg than with 0 and 50 micromol/L Arg, and this was consistent with the expression of the IL-8 receptor on PMNs.	pdf	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
17483743-5	2007	Among the PDF groups, IL-8 secretions from ECs and PMNs were lower with 100 and 1000 micromol/L Arg than with 0 and 50 micromol/L Arg, and this was consistent with the expression of the IL-8 receptor on PMNs.	pdf	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
17483743-5	2007	Among the PDF groups, IL-8 secretions from ECs and PMNs were lower with 100 and 1000 micromol/L Arg than with 0 and 50 micromol/L Arg, and this was consistent with the expression of the IL-8 receptor on PMNs.	Arginine	96-99	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
17483743-5	2007	Among the PDF groups, IL-8 secretions from ECs and PMNs were lower with 100 and 1000 micromol/L Arg than with 0 and 50 micromol/L Arg, and this was consistent with the expression of the IL-8 receptor on PMNs.	Arginine	130-133	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
17483743-5	2007	Among the PDF groups, IL-8 secretions from ECs and PMNs were lower with 100 and 1000 micromol/L Arg than with 0 and 50 micromol/L Arg, and this was consistent with the expression of the IL-8 receptor on PMNs.	Arginine	130-133	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
17483743-8	2007	Inhibition of nitric oxide production results in high CAM and IL-8 expressions comparable with groups with low Arg administration.	Nitric Oxide	14-26	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
17483743-11	2007	Arginine administration at levels similar to or higher than physiological concentrations reduced IL-8 and CAM expression, and PMN transmigration was also decreased after stimulation with plasma or PDF from surgical patients.	Arginine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
17467667-4	2007	Palmitic acid (PA), the predominant saturated FFA released from adipose tissue, but not unsaturated FFA, induced an approximately 6-fold (p&lt;0.05) increase in IP-10 gene expression (and 2- to 4-fold increases in IL-8, MCP-1, COX-2, and MIG).	Palmitic Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
17467667-4	2007	Palmitic acid (PA), the predominant saturated FFA released from adipose tissue, but not unsaturated FFA, induced an approximately 6-fold (p&lt;0.05) increase in IP-10 gene expression (and 2- to 4-fold increases in IL-8, MCP-1, COX-2, and MIG).	Palmitic Acid	15-17	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
17445776-7	2007	Furthermore, CCL-34 treatment stimulated NF-kappaB activation and IL-8 production in a 293 cell line constitutively expressing human TLR4, MD-2 and CD14.	CCL 34	13-19	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
17290398-9	2007	Subcutaneous injection or oral administration of parthenolide showed significant tumor growth inhibition in the xenograft model via decreased production of interleukin-8 (IL-8) or vascular endothelial growth factor (VEGF).	parthenolide	49-61	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
17561043-2	2007	The purpose of this in-vitro study was to investigate the effect of sodium fluoride (Colgate Neutrafluor 9000 ppm) (NaF) and 10% casein phosphopeptide-amorphous calcium phosphate (GC Tooth Mousse) (TM) on enamel demineralization adjacent to orthodontic brackets.	Sodium Fluoride	68-83	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
17512458-6	2007	Treatment of placenta and fetal membranes with 15-A(2)-IsoP caused a dose-dependent decrease in LPS-stimulated release of the cytokines IL-1beta, IL-6, IL-8, and TNF-alpha and the prostaglandins PGE(2) and PGF(2)alpha.	15-a(2)-isop	47-59	C-X-C motif chemokine ligand 8	Homo sapiens	152-156
17141949-5	2007	Interestingly, imatinib mesylate (10 microM) strikingly induced the expression of the pro-inflammatory and pro-angiogenic cytokines interleukin (IL)-6 and IL-8, and mildly stimulated the release of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF).	Imatinib Mesylate	15-32	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
17369293-6	2007	Treatment of A549 cells with monocyte/PM(10) CM produced increased IL-8 release that was reduced with CM from monocyte/PM(10)/calcium antagonist treatments.	Calcium	126-133	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
17322416-10	2007	We further confirmed that sirolimus inhibited mRNA and protein expression of inflammatory cytokines IL-6, tumor necrosis factor-alpha, IL-8, and monocyte chemoattractant protein-1.	Sirolimus	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
17561043-12	2007	Application of TM/NaF with RMGIC significantly reduced DeltaF and %F compared with the control RMGIC (Tukey post-hoc test, P = .008, P = .019, respectively).	Thulium	15-17	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
17561043-16	2007	The application of TM, NaF, or TM/NaF can significantly prevent enamel demineralization when CR is used for bonding.	Chromium	93-95	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
17561043-16	2007	The application of TM, NaF, or TM/NaF can significantly prevent enamel demineralization when CR is used for bonding.	Chromium	93-95	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
17389616-0	2007	Conjugated linoleic acids modulate UVR-induced IL-8 and PGE2 in human skin cells: potential of CLA isomers in nutritional photoprotection.	Linoleic Acids	11-25	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
17418999-5	2007	Finally, an FPRL-1 receptor antagonist, boc-2 peptide reversed LXA(4) effect on IL-8 generation.	N-(1H-benzimidazol-2-ylmethyl)-2-methoxyacetamide	63-66	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
17433258-8	2007	All peptides tested were effective at preventing IL-8 release from phorbol 12-myristate 13-acetate (PMA)/copper-stimulated human umbilical vein endothelial cells (HUVEC).	Tetradecanoylphorbol Acetate	67-98	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
17433258-8	2007	All peptides tested were effective at preventing IL-8 release from phorbol 12-myristate 13-acetate (PMA)/copper-stimulated human umbilical vein endothelial cells (HUVEC).	Tetradecanoylphorbol Acetate	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
17433258-8	2007	All peptides tested were effective at preventing IL-8 release from phorbol 12-myristate 13-acetate (PMA)/copper-stimulated human umbilical vein endothelial cells (HUVEC).	Copper	105-111	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
17389616-8	2007	Additionally, t10,c12-CLA and tt-CLA inhibited TNF-alpha-induced IL-8 from 11 669 +/- 1692 pg/ng protein in control cells to 5540 +/- 191 (P &lt; 0.001) and 8082 +/- 1298 pg/ng (P &lt; 0.01) protein, respectively.	c12-cla	18-25	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
17389616-8	2007	Additionally, t10,c12-CLA and tt-CLA inhibited TNF-alpha-induced IL-8 from 11 669 +/- 1692 pg/ng protein in control cells to 5540 +/- 191 (P &lt; 0.001) and 8082 +/- 1298 pg/ng (P &lt; 0.01) protein, respectively.	tt-cla	30-36	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
17420239-4	2007	Addition of aferric, but not iron-saturated, enterobactin elicits a dose-dependent increase in secretion of the proinflammatory chemokine interleukin-8 by human respiratory epithelial cells in culture.	Enterobactin	45-57	C-X-C motif chemokine ligand 8	Homo sapiens	138-151
17617053-7	2007	In other words, increased reactive oxygen species may induce interleukin-8 production and result in diminished reduced glutathione levels.	Reactive Oxygen Species	26-49	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
17617741-4	2007	In these studies, the effect of 5alpha-dihydrotestosterone (DHT) on the expression levels of IL-6 and IL-8 was investigated.	Dihydrotestosterone	32-58	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
17617741-4	2007	In these studies, the effect of 5alpha-dihydrotestosterone (DHT) on the expression levels of IL-6 and IL-8 was investigated.	Dihydrotestosterone	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
17617741-8	2007	Furthermore, DHT enhanced IL-6 and IL-8 secretion.	Dihydrotestosterone	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
17617741-9	2007	Flutamide (Flu), an AR antagonist, completely abolished DHT-stimulated cell growth and the expression of IL-6 and IL-8.	Flutamide	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
17617741-9	2007	Flutamide (Flu), an AR antagonist, completely abolished DHT-stimulated cell growth and the expression of IL-6 and IL-8.	Flutamide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
17617741-9	2007	Flutamide (Flu), an AR antagonist, completely abolished DHT-stimulated cell growth and the expression of IL-6 and IL-8.	Dihydrotestosterone	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
17538964-7	2007	In particular, the presence of intracellular NS5A led to increased transcriptional and protein expression of IL-8 (CXCL-8), a chemokine with proinflammatory and anti-interferon properties, and impaired interferon induction of signal transducers and activators of transcription 1 (STAT1) serine and tyrosine and STAT2 tyrosine phosphorylation.	Serine	287-293	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
17538964-7	2007	In particular, the presence of intracellular NS5A led to increased transcriptional and protein expression of IL-8 (CXCL-8), a chemokine with proinflammatory and anti-interferon properties, and impaired interferon induction of signal transducers and activators of transcription 1 (STAT1) serine and tyrosine and STAT2 tyrosine phosphorylation.	Tyrosine	298-306	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
17538964-7	2007	In particular, the presence of intracellular NS5A led to increased transcriptional and protein expression of IL-8 (CXCL-8), a chemokine with proinflammatory and anti-interferon properties, and impaired interferon induction of signal transducers and activators of transcription 1 (STAT1) serine and tyrosine and STAT2 tyrosine phosphorylation.	Tyrosine	317-325	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
17420239-8	2007	Although many siderophores perturb labile cellular iron pools, only enterobactin elicits interleukin-8 secretion, suggesting that iron chelation is necessary but not sufficient.	Enterobactin	68-80	C-X-C motif chemokine ligand 8	Homo sapiens	89-102
17295217-7	2007	Furthermore, UTP had no effect on interleukin-(IL)-8 release and reduced the release of both CCL20 and IL-8 induced by TNF-alpha and LPS.	Uridine Triphosphate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
17412724-2	2007	Clarithromycin initially decreases, then increases and finally produces a sustained suppression of interleukin (IL)-8 secretion from normal human bronchial epithelial (NHBE) cells through inhibition and activation of extracellular signal-regulated kinase (ERK).	Clarithromycin	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	99-117
17306288-2	2007	In this work it is clarified how the presence of the alkali halides NaF, LiCl, NaCl, NaBr and NaI in the aqueous solutions, up to high molalities, change the lcb temperature-position and shape.	halides	60-67	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
17577102-7	2007	Rosuvastatin inhibited the expressions of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA and protein levels.	Rosuvastatin Calcium	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
17372146-4	2007	The redistribution of PSGL-1 induced by IL-8 was inhibited by cholesterol-perturbing agents such as methyl-beta-cyclodextrin and filipin.	Cholesterol	62-73	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
17372146-4	2007	The redistribution of PSGL-1 induced by IL-8 was inhibited by cholesterol-perturbing agents such as methyl-beta-cyclodextrin and filipin.	methyl-beta-cyclodextrin	100-124	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
17372146-4	2007	The redistribution of PSGL-1 induced by IL-8 was inhibited by cholesterol-perturbing agents such as methyl-beta-cyclodextrin and filipin.	Filipin	129-136	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
17372146-8	2007	Treatment of neutrophils with IL-8 increased the formation of microaggregates composed of neutrophils and activated platelets, and this treatment also enhanced reactive oxygen species production in neutrophils induced by the cross-linking of PSGL-1 with antibodies.	Reactive Oxygen Species	160-183	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
17314215-2	2007	In this study, we explored the effect of artesunate, an artemisinin derivative, on tumour necrosis factor (TNF)-alpha-induced production of interleukins, IL-1beta, IL-6 and IL-8, in human rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS), and further investigated the signal mechanism by which this compound modulates those cytokines" production.	Artesunate	41-51	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
17314215-6	2007	RESULTS: Artesunate decreased the secretion of IL-1beta, IL-6 and IL-8 from TNF-alpha-stimulated RA FLS in a dose-dependent manner.	Artesunate	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
17314215-8	2007	The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	80-107	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
17314215-8	2007	The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	109-113	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
17314215-9	2007	These observations suggest that artesunate inhibits production of IL-1beta, IL-6 and IL-8 through inhibition of NF-kappaB signalling pathway.	Artesunate	32-42	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
17314215-11	2007	TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
17314215-11	2007	TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	C-X-C motif chemokine ligand 8	Homo sapiens	225-229
17569118-5	2007	RESULTS: Acetate, propionate and butyrate at 30 mmol/L decreased LPS-stimulated TNFalpha release from neutrophils, without affecting IL-8 protein release.	Butyrates	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
17524151-8	2007	Also, roxithromycin inhibited the SM-stimulated overproduction of the proinflammatory cytokines IL-1beta, IL-6, IL-8 and TNF at both the protein level and the mRNA level, as measured by either enzyme-linked immunosorbent assay (ELISA) or real-time RT-PCR.	Roxithromycin	6-19	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
17524151-8	2007	Also, roxithromycin inhibited the SM-stimulated overproduction of the proinflammatory cytokines IL-1beta, IL-6, IL-8 and TNF at both the protein level and the mRNA level, as measured by either enzyme-linked immunosorbent assay (ELISA) or real-time RT-PCR.	Mustard Gas	34-36	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
17218384-6	2007	In NB4 cells, ATRA treatment activates a novel signaling pathway, whereby interleukin-8 stimulates the expression of the homeobox transcription factor HOXA10v2, an effective enhancer of CYP26A1 transcription.	Tretinoin	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
17355968-2	2007	By sensing the muramyl dipeptide (MDP), a bacterial wall component, NOD2 triggers the NF-kappaB signaling pathway and promotes the release of proinflammatory cytokines such as interleukin-8.	Acetylmuramyl-Alanyl-Isoglutamine	15-32	C-X-C motif chemokine ligand 8	Homo sapiens	176-189
17355968-2	2007	By sensing the muramyl dipeptide (MDP), a bacterial wall component, NOD2 triggers the NF-kappaB signaling pathway and promotes the release of proinflammatory cytokines such as interleukin-8.	Acetylmuramyl-Alanyl-Isoglutamine	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	176-189
17543179-6	2007	ELISA was used to detect IL-8 secretion from THCEs challenged with ligands for TLR3 and TLR4 with and without antibody blockade.	thces	45-50	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
17543179-13	2007	Blocking TLR4 with an anti-TLR4 antibody significantly inhibited the LPS-induced IL-8 production by THCE (P &lt; 0.05).	thce	100-104	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
17439270-5	2007	This phenomenon plays a critical role during the solidification process of NaCl-NaF melts of low NaF concentration and is demonstrated to account for the segregation of fluoride ions.	Fluorides	169-177	C-X-C motif chemokine ligand 8	Homo sapiens	80-83
17439270-5	2007	This phenomenon plays a critical role during the solidification process of NaCl-NaF melts of low NaF concentration and is demonstrated to account for the segregation of fluoride ions.	Fluorides	169-177	C-X-C motif chemokine ligand 8	Homo sapiens	97-100
17397353-2	2007	It is now clear that macrolide antibiotics have anti-inflammatory effects, such as inhibition of IL-6, IL-8 and tumour necrosis factor-alpha, perhaps by suppressing the transcription factor nuclear factor-kappaB or activator protein-1, and reduction of neutrophil activity.	Macrolides	21-30	C-X-C motif chemokine ligand 8	Homo sapiens	103-140
17220369-4	2007	In this study we show a signaling pathway on the plasma surface of human airway epithelial NCI-H292 cells that regulate IL-8 production in response to a model inflammatory stimulus, phorbol 12-myristate 13-acetate, and a pathophysiological stimulus, gram-negative bacterial lipopolysaccharide.	Tetradecanoylphorbol Acetate	182-213	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
17220369-8	2007	Last, we show that dual oxidase 1 (Duox1), a homolog of NADPH oxidase in airways, mediates TACE activation and IL-8 expression via generation of reactive oxygen species.	Reactive Oxygen Species	145-168	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
17441793-8	2007	After 3 and 8 h of stimulation, codeine, but not meperidine, activated human mast cells to release monocyte chemoattractant protein-1 (CCL2), regulated on activation, normal T expressed and secreted (RANTES, CCL5) and interleukin-8 (CXCL 8) but not inducible protein-10 (CXCL10).	Codeine	32-39	C-X-C motif chemokine ligand 8	Homo sapiens	218-231
17441793-8	2007	After 3 and 8 h of stimulation, codeine, but not meperidine, activated human mast cells to release monocyte chemoattractant protein-1 (CCL2), regulated on activation, normal T expressed and secreted (RANTES, CCL5) and interleukin-8 (CXCL 8) but not inducible protein-10 (CXCL10).	Codeine	32-39	C-X-C motif chemokine ligand 8	Homo sapiens	233-239
17494953-3	2007	We applied cigarette smoke water extract (CSE) to primary human lung fibroblasts and found that CSE significantly increased CXC chemokine IL-8 production.	Water	27-32	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
17224841-4	2007	Polymethylmethacrylate elicited a six- to 12-fold increase in gene expression of tumor necrosis factor alpha, interleukin 1alpha, interleukin 1beta, interleukin 6, and interleukin 8 in purified monocytes and unfractionated peripheral blood mononuclear cells.	Polymethyl Methacrylate	0-22	C-X-C motif chemokine ligand 8	Homo sapiens	168-181
17379503-6	2007	Treatment with the tyrosine kinase inhibitor gefitinib (Iressa) returned the expression levels of IL-8 and GRO back to the baseline observed in MCF-7 breast cancer cells, which express physiological levels of HER2.	Gefitinib	45-54	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
17386409-5	2007	Panepoxydone strongly inhibited hTNF-alpha, IL-8 and NF-kappaB promoter activity in LPS/TPA stimulated MonoMac6 cells with IC(50) values of 0.5-1 microg/ml by blocking the phosphorylation of IkappaB and subsequent binding of the activated NF-kappaB transcription factor to the DNA.	panepoxydone	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
17588137-5	2007	RESULTS: Quercetin decreased the gene expression and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in PMACI-stimulated HMC-1 cells.	Quercetin	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
17460254-0	2007	Mitomycin C upregulates IL-8 and MCP-1 chemokine expression via mitogen-activated protein kinases in corneal fibroblasts.	Mitomycin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
17353033-4	2007	Blocking neutrophil chemotactic factors such as leukotriene B(4) and IL-8 and related cysteine-X-cysteine chemokines by blocking receptor for leukotriene B(4) 1 and receptor for cysteine-X-cysteine chemokines 2 receptors is an approach that is currently being investigated.	Leukotriene B4	48-61	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
17353033-4	2007	Blocking neutrophil chemotactic factors such as leukotriene B(4) and IL-8 and related cysteine-X-cysteine chemokines by blocking receptor for leukotriene B(4) 1 and receptor for cysteine-X-cysteine chemokines 2 receptors is an approach that is currently being investigated.	cysteine-x-cysteine	86-105	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
17353033-4	2007	Blocking neutrophil chemotactic factors such as leukotriene B(4) and IL-8 and related cysteine-X-cysteine chemokines by blocking receptor for leukotriene B(4) 1 and receptor for cysteine-X-cysteine chemokines 2 receptors is an approach that is currently being investigated.	Leukotrienes	48-59	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
17353033-4	2007	Blocking neutrophil chemotactic factors such as leukotriene B(4) and IL-8 and related cysteine-X-cysteine chemokines by blocking receptor for leukotriene B(4) 1 and receptor for cysteine-X-cysteine chemokines 2 receptors is an approach that is currently being investigated.	cysteine-x-cysteine	178-197	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
17386409-5	2007	Panepoxydone strongly inhibited hTNF-alpha, IL-8 and NF-kappaB promoter activity in LPS/TPA stimulated MonoMac6 cells with IC(50) values of 0.5-1 microg/ml by blocking the phosphorylation of IkappaB and subsequent binding of the activated NF-kappaB transcription factor to the DNA.	Tetradecanoylphorbol Acetate	88-91	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
17460254-6	2007	RESULTS: The expression of IL-8 and MCP-1 were upregulated after MMC treatment in a time- and concentration-dependent manner.	Mitomycin	65-68	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
17460254-9	2007	The MMC-related IL-8 and MCP-1 expression was inhibited by both a p38 inhibitor (SB203580) and an ERK inhibitor (PD98059).	SB 203580	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
17460254-9	2007	The MMC-related IL-8 and MCP-1 expression was inhibited by both a p38 inhibitor (SB203580) and an ERK inhibitor (PD98059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	113-120	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
17460254-11	2007	CONCLUSIONS: MMC treatment upregulated the expression of IL-8 and MCP-1 mRNA and protein secretion by the activation of mitogen-activated protein kinases (MAPKs) in corneal fibroblasts.	Mitomycin	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
17124504-8	2007	This epoxide also induced pronounced DC activation indicated by upregulation of IL-8.	Epoxy Compounds	5-12	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
17336340-7	2007	As well, hemin-induced IL-8 secretion was significantly reduced in a concentration-dependent fashion following pyrrolidine dithiocarbamate exposure, suggesting that induction occurred via an oxidant-sensitive mechanism.	pyrrolidine dithiocarbamic acid	111-138	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
17207890-5	2007	TNF-alpha stimulated expression of both chemokines, while the PKCalpha/beta activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced only expression of IL-8 and inhibited TNF-alpha-induced RANTES expression.	Tetradecanoylphorbol Acetate	86-123	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
17207890-5	2007	TNF-alpha stimulated expression of both chemokines, while the PKCalpha/beta activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced only expression of IL-8 and inhibited TNF-alpha-induced RANTES expression.	Tetradecanoylphorbol Acetate	125-128	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
17207890-7	2007	In contrast, it decreased TNF-alpha or TPA-induced IL-8 release.	Tetradecanoylphorbol Acetate	39-42	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
17207890-10	2007	An AP-1 and a NF-kappaB recognition sites were necessary for full induction of IL-8 promoter activity by TNF-alpha and TPA.	Tetradecanoylphorbol Acetate	119-122	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
17442957-7	2007	Third, pharmacologic inhibition of PKC or PKD with Go6976 resulted in reduced expression and secretion of IL-8 and prevented the flagellin-induced activation of p38 MAPK, but treatment with the PKC inhibitor Go6983 had no significant effects on these phenotypes.	Go 6976	51-57	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
17442957-7	2007	Third, pharmacologic inhibition of PKC or PKD with Go6976 resulted in reduced expression and secretion of IL-8 and prevented the flagellin-induced activation of p38 MAPK, but treatment with the PKC inhibitor Go6983 had no significant effects on these phenotypes.	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide	208-214	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
17336340-0	2007	Hypoxia inducible factor-1 modulates hemin-induced IL-8 secretion in microvascular endothelium.	Hemin	37-42	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
17336340-11	2007	Activation of HIF-1 via the prolyl hydroxylase inhibitor dimethyloxalylglycine attenuated hemin-induced IL-8 secretion.	oxalylglycine	57-78	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
17511218-4	2007	In addition, it has been shown that bile acids and trypsin can promote IL-8 production from human esophageal epithelial cells via NFkappaB-and AP-1-dependent mechanism.	Bile Acids and Salts	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
17262802-7	2007	RESULTS: Treatment with alpha-tocopherol succinate (VES) inhibits NF-kappaB but augments AP-1 activity, reduces expression of IL-6, IL-8, and VEGF, suppresses cell adhesion, ICAM-1 and gp130 expression in androgen-independent PC-3, DU-145, and CA-HPV-10 cells.	alpha-Tocopherol	24-50	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
17400256-8	2007	In vitro, HES suppressed the expression of IL-8 on A549 cells and THP-1 cells, the expression of TNF-alpha, IL-1 beta, and IL-6 on THP-1 cells, the expression of ICAM-1 and VCAM-1 on A549 cells which effect cell adhesion function.	Hesperidin	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
17400256-10	2007	HES inhibits those pathways, thereby suppressing the expression of IL-8, TNFalpha, IL-1 beta, IL-6, IL-12, ICAM-1 and VCAM-1.	Hesperidin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
17164077-6	2007	Serum estradiol concentration showed a significant negative correlation with serum IL-6 concentration and weak negative correlations with serum concentrations of IL-2, IL-8 and GM-CSF.	Estradiol	6-15	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
17306937-0	2007	The role of sphingosine 1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells.	sphingosine 1-phosphate	12-35	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
17303577-4	2007	Here, we show the differential modulation of NF-kappaB activation and interleukin-8 (IL-8) expression in colonic epithelial cells HCT116 by saturated and unsaturated fatty acids mediated through Nods proteins.	saturated and unsaturated fatty acids	140-177	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
17303577-4	2007	Here, we show the differential modulation of NF-kappaB activation and interleukin-8 (IL-8) expression in colonic epithelial cells HCT116 by saturated and unsaturated fatty acids mediated through Nods proteins.	saturated and unsaturated fatty acids	140-177	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
17303577-5	2007	Lauric acid (C12:0) dose dependently activated NF-kappaB and induced IL-8 expression in HCT116 cells, which express both Nod1 and Nod2, but not detectable amounts of TLR2 and TLR4.	lauric acid	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
17303577-8	2007	In contrast, polyunsaturated fatty acids, especially n-3 polyunsaturated fatty acids, inhibited the activation of NF-kappaB and IL-8 expression induced by lauric acid or known Nods ligands in HCT116.	Fatty Acids, Unsaturated	13-40	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
17303577-8	2007	In contrast, polyunsaturated fatty acids, especially n-3 polyunsaturated fatty acids, inhibited the activation of NF-kappaB and IL-8 expression induced by lauric acid or known Nods ligands in HCT116.	Fatty Acids, Omega-3	53-84	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
17303577-8	2007	In contrast, polyunsaturated fatty acids, especially n-3 polyunsaturated fatty acids, inhibited the activation of NF-kappaB and IL-8 expression induced by lauric acid or known Nods ligands in HCT116.	lauric acid	155-166	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
17439648-8	2007	Further, nanocurcumin"s mechanisms of action on pancreatic cancer cells mirror that of free curcumin, including induction of cellular apoptosis, blockade of nuclear factor kappa B (NFkappaB) activation, and downregulation of steady state levels of multiple pro-inflammatory cytokines (IL-6, IL-8, and TNFalpha).	Curcumin	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	291-295
17404307-9	2007	Moreover, Pen c 13-mediated IL-8 release was significantly decreased in Ca(2+)-free medium and was abolished by the protease inhibitors, PMSF and 4-(2-aminoethyl) benzenesulfonyl fluoride.	Phenylmethylsulfonyl Fluoride	137-141	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
17404307-9	2007	Moreover, Pen c 13-mediated IL-8 release was significantly decreased in Ca(2+)-free medium and was abolished by the protease inhibitors, PMSF and 4-(2-aminoethyl) benzenesulfonyl fluoride.	4-(2-aminoethyl)benzenesulfonylfluoride	146-187	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
17306937-3	2007	Although sphingolipids such as ceramide and sphingosine 1-phosphate (S1-P) have been shown to serve as signaling molecules in the TNF-alpha inflammatory response, their role in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells is not known.	Ceramides	31-39	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
17306937-3	2007	Although sphingolipids such as ceramide and sphingosine 1-phosphate (S1-P) have been shown to serve as signaling molecules in the TNF-alpha inflammatory response, their role in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells is not known.	sphingosine 1-phosphate	44-67	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
17306937-3	2007	Although sphingolipids such as ceramide and sphingosine 1-phosphate (S1-P) have been shown to serve as signaling molecules in the TNF-alpha inflammatory response, their role in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells is not known.	sphingosine 1-phosphate	69-73	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
17306937-4	2007	We investigated the role of sphingolipids in the TNF-alpha induction of IL-8 gene expression in H441 lung epithelial cells.	Sphingolipids	28-41	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
17306937-7	2007	Dimethylsphingosine, an inhibitor of sphingosine kinase, partially inhibited TNF-alpha induction of IL-8 mRNA levels indicating the importance of intracellular increases in S1-P in the IL-8 induction.	dimethylsphingosine	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
17306937-7	2007	Dimethylsphingosine, an inhibitor of sphingosine kinase, partially inhibited TNF-alpha induction of IL-8 mRNA levels indicating the importance of intracellular increases in S1-P in the IL-8 induction.	dimethylsphingosine	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
17306937-3	2007	Although sphingolipids such as ceramide and sphingosine 1-phosphate (S1-P) have been shown to serve as signaling molecules in the TNF-alpha inflammatory response, their role in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells is not known.	Sphingolipids	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
17378789-7	2007	In these cases, the pain score decreased from 6.7 +/- 0.5 (mean +/- standard error of the mean) to 3.3 +/- 0.3 (P &lt; 0.05), and the CSF concentrations of IL-8 and PGE(2) decreased significantly compared with pre-treatment levels (IL-8, 183.3 +/- 21.2 to 116.5 +/- 10.6 pg/ml; PGE(2), 43.8 +/- 10.3 to 14.7 +/- 3.0 pg/ml).	Prostaglandins E	165-168	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
21730373-4	2007	Significant topographical changes were observed following exposure to aqueous solutions of ethylenediaminetetraacetic acid (EDTA) or highly concentrated sodium fluoride (NaF).	Sodium Fluoride	153-168	C-X-C motif chemokine ligand 8	Homo sapiens	170-173
17378789-7	2007	In these cases, the pain score decreased from 6.7 +/- 0.5 (mean +/- standard error of the mean) to 3.3 +/- 0.3 (P &lt; 0.05), and the CSF concentrations of IL-8 and PGE(2) decreased significantly compared with pre-treatment levels (IL-8, 183.3 +/- 21.2 to 116.5 +/- 10.6 pg/ml; PGE(2), 43.8 +/- 10.3 to 14.7 +/- 3.0 pg/ml).	Prostaglandins E	278-281	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
17378789-9	2007	CONCLUSION: Pain relief with intrathecal betamethasone is related to decreases in the CSF concentration of IL-8 and PGE(2).	Betamethasone	41-54	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
17242997-1	2007	Using a cell stretcher device, we have previously shown that A549 cells exposed to asbestos fibers gave significantly increased cytokine responses (IL-8) when they were cyclically stretched [Tsuda, A., B. K. Stringer, S. M. Mijailovich, R. A. Rogers, K. Hamada, and M. L. Gray.	Asbestos	83-91	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
17222322-6	2007	Serum beta-CTx correlated negatively with serum PIIINP and proinflammatory cytokines (IL-2, IL-6, IL-8, TNF-alpha), and positively with anti-inflammatory cytokines (IL-1, TGF-beta), whereas serum PIIINP correlated positively with these proinflammatory cytokines and negatively with the anti-inflammatory cytokines.	beta-ctx	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
17242997-9	2007	Although it is generally assumed that riebeckite particles do not elicit strong biological responses, in our studies in cyclically stretched cell cultures, the riebeckite particles coated with adhesion proteins induced significant IL-8 responses, but in static cell cultures the treatment with adhesion protein-coated riebeckite did not induce comparable cytokine responses.	Asbestos, Crocidolite	160-170	C-X-C motif chemokine ligand 8	Homo sapiens	231-235
17242997-9	2007	Although it is generally assumed that riebeckite particles do not elicit strong biological responses, in our studies in cyclically stretched cell cultures, the riebeckite particles coated with adhesion proteins induced significant IL-8 responses, but in static cell cultures the treatment with adhesion protein-coated riebeckite did not induce comparable cytokine responses.	Asbestos, Crocidolite	160-170	C-X-C motif chemokine ligand 8	Homo sapiens	231-235
17576072-0	2007	Serum concentrations of interleukin-8 in relation to different levels of alcohol consumption.	Alcohols	73-80	C-X-C motif chemokine ligand 8	Homo sapiens	24-37
17240460-6	2007	Analysis of gene and protein expression determined a selectively increase of the pro-inflammatory cytokines monocyte chemoattractant protein (MCP)-1 and interleukin-8 (IL-8) following exposure to a pharmacological concentration of NFV and RTV.	Nelfinavir	231-234	C-X-C motif chemokine ligand 8	Homo sapiens	153-166
17240460-6	2007	Analysis of gene and protein expression determined a selectively increase of the pro-inflammatory cytokines monocyte chemoattractant protein (MCP)-1 and interleukin-8 (IL-8) following exposure to a pharmacological concentration of NFV and RTV.	Nelfinavir	231-234	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
17240460-6	2007	Analysis of gene and protein expression determined a selectively increase of the pro-inflammatory cytokines monocyte chemoattractant protein (MCP)-1 and interleukin-8 (IL-8) following exposure to a pharmacological concentration of NFV and RTV.	Ritonavir	239-242	C-X-C motif chemokine ligand 8	Homo sapiens	153-166
17240460-6	2007	Analysis of gene and protein expression determined a selectively increase of the pro-inflammatory cytokines monocyte chemoattractant protein (MCP)-1 and interleukin-8 (IL-8) following exposure to a pharmacological concentration of NFV and RTV.	Ritonavir	239-242	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
16984938-7	2007	Prednisolone markedly decreased IL8 and MMP1 expression compared with placebo, and the CIs excluded the likelihood of no effect.	Prednisolone	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
17383342-8	2007	RESULTS: Simvastatin significantly reduced the postoperative peak values of interleukin (IL)-6 and IL-8.	Simvastatin	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
17339835-1	2007	In this issue of British Journal of Pharmacology, Megias and colleagues demonstrate how preincubation of human colonic Caco-2 cells with CORM-2, a carbon monoxide releasing molecule (CO-RM), reduces the expression of inducible nitric oxide synthase, interleukin (IL)-6 and IL-8 caused by proinflammatory cytokines.	Carbon Monoxide	147-162	C-X-C motif chemokine ligand 8	Homo sapiens	273-277
17286758-5	2007	Cycloheximide reduced the UVB-mediated induction of IL-8 by 30-40%, suggesting that new protein synthesis contributed to IL-8 production.	Cycloheximide	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
17286758-5	2007	Cycloheximide reduced the UVB-mediated induction of IL-8 by 30-40%, suggesting that new protein synthesis contributed to IL-8 production.	Cycloheximide	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
17576072-2	2007	The present study was aimed at investigating serum IL-8 levels in relation to different levels of alcohol consumption.	Alcohols	98-105	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
17576072-4	2007	The proportion of individuals with abnormally high (&gt;10 pg/mL) IL-8 levels increased with alcohol use from 5.9% in abstainers to 10.7% in light, 13.2% in moderate, and 17.8% in heavy drinkers (P=0.004).	Alcohols	93-100	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
17576072-6	2007	Extremely high (&gt;100 pg/mL) IL-8 levels were only observed among alcoholics, and were more frequent in females than in males (23.5% versus 9.7%, P=0.03) in spite of lower alcohol consumption among the former.	Alcohols	68-75	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
17576072-7	2007	These data indicate that the effect of alcohol on serum IL-8 levels begins with light-to-moderate drinking and is dose-dependent.	Alcohols	39-46	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
17576072-8	2007	Females may be more prone than males to develop extremely high IL-8 levels after heavy alcohol intake.	Alcohols	87-94	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
17227950-6	2007	Levels of the angiogenic chemokine CXCL1 (mouse functional homologue of human IL-8) were found to be elevated in an adenosine-dependent manner in the lungs of ADA-deficient mice.	Adenosine	116-125	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
17024463-0	2007	Identification of the dimerisation interface of human interleukin-8 by IL-8-variants containing the photoactivatable amino acid benzoyl-phenylalanine.	amino acid benzoyl-phenylalanine	117-149	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
17024463-0	2007	Identification of the dimerisation interface of human interleukin-8 by IL-8-variants containing the photoactivatable amino acid benzoyl-phenylalanine.	amino acid benzoyl-phenylalanine	117-149	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
17024463-4	2007	In order to obtain a better understanding of the dimerisation process, covalently linked homo- and heterodimers were produced by photo-induced dimerisation of hIL-8 analogues that contain the photo-activatable amino acid p-benzoyl-phenylalanine (Bpa) at different positions.	amino acid p-benzoyl-phenylalanine	210-244	C-X-C motif chemokine ligand 8	Homo sapiens	159-164
17024463-4	2007	In order to obtain a better understanding of the dimerisation process, covalently linked homo- and heterodimers were produced by photo-induced dimerisation of hIL-8 analogues that contain the photo-activatable amino acid p-benzoyl-phenylalanine (Bpa) at different positions.	4-benzoylphenylalanine	246-249	C-X-C motif chemokine ligand 8	Homo sapiens	159-164
17024463-6	2007	The segments were combined by expressed protein ligation and led to full length IL-8 variants containing the non-proteinogenic amino acid Bpa at single positions.	4-benzoylphenylalanine	138-141	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
17359338-7	2007	Cadexomer and cadexomer iodine significantly increased the expression of IL-1 beta, IL-8, TNF-alpha and VEGF mRNA, while they did not affect that of IL-6, IL-10, IL-12 p 40 or bFGF mRNA.	Iodine	24-30	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
17873318-7	2007	However, in linear regression analysis, BMI, diastolic blood pressure, glucose, insulin, and IL-8 emerged as significant predictors of ADMA.	N,N-dimethylarginine	135-139	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
16952401-8	2007	In conclusion, MgSO(4) inhibits endothelial cell activation, as measured by levels of IL-8 and ICAM-1 expression, via NFkappaB.	mgso	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
16900358-3	2007	Supernatants of histamine-stimulated cells were evaluated for the production of IL-6 and IL-8 by ELISA, while the expression of ICAM-1 was evaluated by flow cytometry on IFN gamma-stimulated cells.	Histamine	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
17414009-1	2007	PURPOSE: Skeletal positron emission tomography (PET) with fluorine-18 (18F) sodium fluoride (18F NaF) is an alternative to technetium-99m (99mTc)methylene diphosphonate (MDP) scintigraphy.	fluorine-18 (18f) sodium fluoride	58-91	C-X-C motif chemokine ligand 8	Homo sapiens	97-100
17384028-6	2007	Fluoride had a biphasic effect on cell proliferation, with enhanced proliferation at 16 microM, and reduced proliferation at greater than 1 mM F. Flow cytometry showed that both 10 microM and 20 microM NaF significantly increased the apoptotic index of ameloblast-lineage cells.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	202-205
17118622-7	2007	Also, TNF-alpha and IL-8 secretion were markedly induced by DNCB and NiSO(4) in a dose-dependent manner.	Dinitrochlorobenzene	60-64	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
17431105-9	2007	Tumors from animals treated with liposomal curcumin showed an antiangiogenic effect, including attenuation of CD31 (an endothelial marker), vascular endothelial growth factor, and interleukin-8 expression by immunohistochemistry.	Curcumin	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	180-193
17118622-7	2007	Also, TNF-alpha and IL-8 secretion were markedly induced by DNCB and NiSO(4) in a dose-dependent manner.	niso	69-73	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
17307163-5	2007	However, activation with PGD2 in the presence of tumor necrosis factor (TNF)-alpha mediated significant production of MCP-1 and IL-8, but not the other cytokines and chemokines, in comparison to single stimulation with TNF-alpha.	Prostaglandin D2	25-29	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
17628972-6	2007	RESULTS: IL-5, IL-6 and IL-8 levels in both AR and NAR groups were significantly elevated compared with normal group (all P &lt; 0.01 for AR group; P &lt; 0.05, 0.05, 0.01 for NAR group, respectively), and they were much higher in AR group in comparison with NAR group (P &lt; 0.01, 0.05, 0.01, respectively).	Argon	44-46	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
17628972-6	2007	RESULTS: IL-5, IL-6 and IL-8 levels in both AR and NAR groups were significantly elevated compared with normal group (all P &lt; 0.01 for AR group; P &lt; 0.05, 0.05, 0.01 for NAR group, respectively), and they were much higher in AR group in comparison with NAR group (P &lt; 0.01, 0.05, 0.01, respectively).	Argon	52-54	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
17307163-0	2007	Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha-induced production of MCP-1 and IL-8 in human monocytic THP-1 cells.	Prostaglandin D2	22-26	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
17307163-6	2007	In addition, the selective prostanoid DP receptor antagonist, pinagladin ((Z)-7-[(1R,2R,3S,5S)-2-(benzothiophen-3-ylcarbonylamide)-10-norpinan-3-yl]hept-5-enoic acid) inhibited the production of MCP-1 and IL-8 upon combined stimulation with PGD2 and TNF-alpha.	pinagladin	62-72	C-X-C motif chemokine ligand 8	Homo sapiens	205-209
17307163-6	2007	In addition, the selective prostanoid DP receptor antagonist, pinagladin ((Z)-7-[(1R,2R,3S,5S)-2-(benzothiophen-3-ylcarbonylamide)-10-norpinan-3-yl]hept-5-enoic acid) inhibited the production of MCP-1 and IL-8 upon combined stimulation with PGD2 and TNF-alpha.	(Z)-7-((1R,2R,3S,5S)-2-(benzothiophen-3-ylcarbonylamide)-10-norpinan-3-yl)hept-5-enoic acid	74-165	C-X-C motif chemokine ligand 8	Homo sapiens	205-209
17307163-7	2007	The synergistic production of MCP-1 and IL-8 by PGD2 was mimicked by dibutyryl cAMP (db-cAMP) and was inhibited by a protein kinase A (PKA) inhibitor.	Prostaglandin D2	48-52	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
17307163-7	2007	The synergistic production of MCP-1 and IL-8 by PGD2 was mimicked by dibutyryl cAMP (db-cAMP) and was inhibited by a protein kinase A (PKA) inhibitor.	Bucladesine	69-83	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
17307163-7	2007	The synergistic production of MCP-1 and IL-8 by PGD2 was mimicked by dibutyryl cAMP (db-cAMP) and was inhibited by a protein kinase A (PKA) inhibitor.	Bucladesine	85-92	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
17307163-8	2007	Our findings suggest that activation of the prostanoid DP receptor on THP-1 cells enhances TNF-alpha-induced MCP-1 and IL-8 production via the cAMP/PKA signaling pathway.	Cyclic AMP	143-147	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
16860297-7	2007	Exposure to the photochemically generated products of BD (primarily acrolein, acetaldehyde, formaldehyde, furan and ozone) induced significant increases in cytotoxicity, IL-8, and IL-6 gene expression compared to a synthetic mixture of primary products that was created by injecting the correct concentrations of the detected products from the irradiation experiments.	Acrolein	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
20641299-0	2004	(99m)Tc-Hydrazinonicotinamide-interleukin-8 Interleukin-8 (IL-8) has a molecular mass of 8.5 kDa and is an inflammatory chemokine secreted by many cell types (1).	tc-hydrazinonicotinamide	5-29	C-X-C motif chemokine ligand 8	Homo sapiens	44-57
20641299-0	2004	(99m)Tc-Hydrazinonicotinamide-interleukin-8 Interleukin-8 (IL-8) has a molecular mass of 8.5 kDa and is an inflammatory chemokine secreted by many cell types (1).	tc-hydrazinonicotinamide	5-29	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
20641299-6	2004	The ready availability and low cost of (99m)Tc led to the development of (99m)Tc-IL-8 for studying activated leukocytes in inflamed and infective tissues (3-8).	Technetium	44-46	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
17375198-9	2007	MMP-8 cleaves CXCL8 at Arg(5)-Ser(6) and at Val(7)-Leu(8) in CXCL5 to activate respective chemokines.	Arginine	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	14-19
16860297-7	2007	Exposure to the photochemically generated products of BD (primarily acrolein, acetaldehyde, formaldehyde, furan and ozone) induced significant increases in cytotoxicity, IL-8, and IL-6 gene expression compared to a synthetic mixture of primary products that was created by injecting the correct concentrations of the detected products from the irradiation experiments.	Acetaldehyde	78-90	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
17375198-9	2007	MMP-8 cleaves CXCL8 at Arg(5)-Ser(6) and at Val(7)-Leu(8) in CXCL5 to activate respective chemokines.	Serine	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	14-19
16860297-7	2007	Exposure to the photochemically generated products of BD (primarily acrolein, acetaldehyde, formaldehyde, furan and ozone) induced significant increases in cytotoxicity, IL-8, and IL-6 gene expression compared to a synthetic mixture of primary products that was created by injecting the correct concentrations of the detected products from the irradiation experiments.	Ozone	116-121	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
17339475-5	2007	CoMTb-induced prolonged dose-dependent, p38-mediated expression of stable CXCL8 mRNA by fibroblasts accompanied by a &gt;10-fold increase in CXCL8 secretion (487 +/- 88 ng/ml vs 48.6 +/- 34 ng/ml in controls) at 120 h. Fibroblasts strongly expressed CXCL8 in vivo in human TB granulomas.	comtb	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	74-79
17339475-5	2007	CoMTb-induced prolonged dose-dependent, p38-mediated expression of stable CXCL8 mRNA by fibroblasts accompanied by a &gt;10-fold increase in CXCL8 secretion (487 +/- 88 ng/ml vs 48.6 +/- 34 ng/ml in controls) at 120 h. Fibroblasts strongly expressed CXCL8 in vivo in human TB granulomas.	comtb	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	141-146
17339475-5	2007	CoMTb-induced prolonged dose-dependent, p38-mediated expression of stable CXCL8 mRNA by fibroblasts accompanied by a &gt;10-fold increase in CXCL8 secretion (487 +/- 88 ng/ml vs 48.6 +/- 34 ng/ml in controls) at 120 h. Fibroblasts strongly expressed CXCL8 in vivo in human TB granulomas.	comtb	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	141-146
17339489-7	2007	The stimulatory role was confirmed by the observation that 12.5 microM H(2)O(2), a concentration found during inflammation, increased the expression of several proinflammatory NF-kappaB-dependent genes induced by TNF-alpha (e.g., IL-8, MCP-1, TLR2, and TNF-alpha).	Water	71-77	C-X-C motif chemokine ligand 8	Homo sapiens	230-234
17095757-0	2007	Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells.	Carrageenan	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	20-33
17293063-6	2007	Genes up-regulated by selenium supplementation included TNF, IL1B, IL8, SOD2, CXCL2 and several other immunological and oxidative stress-related genes.	Selenium	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
17095757-5	2007	Increased Bcl10, nuclear and cytoplasmic NF-kappaB, IL-8 promoter activation, and IL-8 secretion were detected following carrageenan exposure.	Carrageenan	121-132	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
17095757-5	2007	Increased Bcl10, nuclear and cytoplasmic NF-kappaB, IL-8 promoter activation, and IL-8 secretion were detected following carrageenan exposure.	Carrageenan	121-132	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
17095757-6	2007	Knockdown of Bcl10 by siRNA markedly reduced the increase in IL-8 that followed carrageenan exposure in the NCM460 cells.	Carrageenan	80-91	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
17095757-7	2007	These results show, for the first time, that exposure of human intestinal epithelial cells to carrageenan triggers a distinct inflammatory pathway via activation of Bcl10 with NF-kappaB activation and upregulation of IL-8 secretion.	Carrageenan	94-105	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
17138957-9	2007	The NO donor S-nitroso-N-acetyl-d,l-penicillamine inhibited CXCL8-induced human neutrophil chemotaxis and CXCR2 expression on human and murine neutrophils.	snap	13-49	C-X-C motif chemokine ligand 8	Homo sapiens	60-65
17158355-3	2007	METHODS AND RESULTS: Treatment of endothelial cells with anthocyanin prevented from CD40-induced proinflammatory status, measured by production of IL-6, IL-8, and monocyte chemoattractant protein-1 through inhibiting CD40-induced nuclear factor-kappaB (NF-kappaB) activation.	Anthocyanins	57-68	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
17235257-15	2007	CONCLUSIONS: IL-8 and GRO-alpha secreted from alveolar epithelial cells play an important role in the cell-cell interaction involved in the chemotactic transmigration of ATRA-treated APL cells toward alveolar epithelial cells.	Tretinoin	170-174	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
17453947-11	2007	They also enhanced IL-8 gene expression and IL-8 protein secretion in the following decreasing order: 25-hydroxycholesterol &gt; 24-hydroxycholesterol &gt; 7-ketocholesterol.	25-hydroxycholesterol	102-123	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
17453947-11	2007	They also enhanced IL-8 gene expression and IL-8 protein secretion in the following decreasing order: 25-hydroxycholesterol &gt; 24-hydroxycholesterol &gt; 7-ketocholesterol.	25-hydroxycholesterol	102-123	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
17235257-0	2007	Role of interleukin-8 and growth-regulated oncogene-alpha in the chemotactic migration of all-trans retinoic acid-treated promyelocytic leukemic cells toward alveolar epithelial cells.	Tretinoin	100-113	C-X-C motif chemokine ligand 8	Homo sapiens	8-21
17235257-2	2007	We investigated the role of interleukin (IL)-8 and growth-regulated oncogene (GRO)-alpha in the chemotactic transmigration of ATRA-treated NB4 (ATRA-NB4) APL cells toward A549 alveolar epithelial cells.	Tretinoin	126-130	C-X-C motif chemokine ligand 8	Homo sapiens	28-46
17364953-0	2007	25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages.	25-hydroxycholesterol	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
17235257-10	2007	Only A549 cells constitutively secreted GRO-alpha, and both A549 and NB4 cells constitutively secreted IL-8, which was enhanced by ATRA.	Tretinoin	131-135	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
17359210-1	2007	AIM: Aim of the present study was to evaluate the salivary clearance of Fluoride following administration of tablets and chewing gums containing 0.50 mg of Fluoride in the form of NaF.	Fluorides	72-80	C-X-C motif chemokine ligand 8	Homo sapiens	180-183
17359210-1	2007	AIM: Aim of the present study was to evaluate the salivary clearance of Fluoride following administration of tablets and chewing gums containing 0.50 mg of Fluoride in the form of NaF.	Fluorides	156-164	C-X-C motif chemokine ligand 8	Homo sapiens	180-183
17453947-11	2007	They also enhanced IL-8 gene expression and IL-8 protein secretion in the following decreasing order: 25-hydroxycholesterol &gt; 24-hydroxycholesterol &gt; 7-ketocholesterol.	24-hydroxycholesterol	129-150	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
17453947-11	2007	They also enhanced IL-8 gene expression and IL-8 protein secretion in the following decreasing order: 25-hydroxycholesterol &gt; 24-hydroxycholesterol &gt; 7-ketocholesterol.	7-ketocholesterol	156-173	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
17621943-3	2007	In artificial saliva containing 0.1% NaF at a pH of 4.0, the amounts of Ti dissolved from the Ti, Ti-6Al-4V, and Ti-6Al-7Nb alloys were about 50 times larger than those of the alloys containing 0.5 wt% Pt.	Platinum	202-204	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
17286808-8	2007	In addition, secretion of proinflammatory mediators such as the cytokines interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF alpha), IL-6 and IL-8 were inhibited in the presence of physiological doses of OMZ.	Oxymetazoline	216-219	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
17364953-0	2007	25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages.	cholest-5-en-3 beta,7 alpha-diol	23-47	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
17364953-0	2007	25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages.	7-ketocholesterol	52-69	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
17364953-3	2007	Each oxysterol stimulated secretion of the inflammatory chemokine interleukin-8 (IL-8), but not IkappaBalpha degradation or tumour necrosis factor-alpha release from monocytic THP-1 cells.	Oxysterols	5-14	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
17364953-3	2007	Each oxysterol stimulated secretion of the inflammatory chemokine interleukin-8 (IL-8), but not IkappaBalpha degradation or tumour necrosis factor-alpha release from monocytic THP-1 cells.	Oxysterols	5-14	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
17406807-2	2007	METHODS: Neutrophils were incubated with different concentrations of omeprazole and pantoprazole for 30 min and stimulated to migrate with fMLP and IL-8.	Omeprazole	69-79	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
16715250-0	2007	(E)-metanicotine hemigalactarate (TC-2403-12) inhibits IL-8 production in cells of the inflamed mucosa.	(e)-metanicotine hemigalactarate	0-32	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
16715250-0	2007	(E)-metanicotine hemigalactarate (TC-2403-12) inhibits IL-8 production in cells of the inflamed mucosa.	metanicotine	34-44	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
17406807-2	2007	METHODS: Neutrophils were incubated with different concentrations of omeprazole and pantoprazole for 30 min and stimulated to migrate with fMLP and IL-8.	Pantoprazole	84-96	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
16715250-8	2007	RESULTS: In MM6 cells, IL-8 secretion was significantly decreased to 30% of control after TC-2403-12 treatment, with best results after pretreatment for 24 h. This decrease in cell activation was not due to apoptosis and was not mediated by inhibition of NF-kappaB activation.	metanicotine	90-100	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
16715250-9	2007	IL-8 production in neutrophils and primary CEC also tended to be decreased after TC-2403-12 treatment.	metanicotine	81-91	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
17406807-6	2007	RESULTS: Omeprazole is able to inhibit neutrophil chemotaxis to fMLP and IL-8.	Omeprazole	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
16715250-11	2007	CONCLUSION: TC-2403-12 effectively inhibited TNF- and LPS-induced IL-8 production in different cell types.	metanicotine	12-22	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
17273783-6	2007	Moreover, the intracellular levels and secretion rates of IL-8 were also markedly reduced in the protein extracts and conditioned media of CW-DMEM-incubated keratinocytes.	dmem	142-146	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
17430259-11	2007	Olprinone inhibited the increase in the IL-8 levels resulting from the incubation of HK-2 with TNF-alpha.	olprinone	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
17273783-7	2007	Notably, the most effective inhibition of IL-8 secretion was elicited by a 25% CW fraction in the DMEM.	dmem	98-102	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
17273783-0	2007	Comano"s (Trentino) thermal water interferes with tumour necrosis factor-alpha expression and interleukin-8 production and secretion by cultured human psoriatic keratinocytes: yet other mechanisms of its anti-psoriatic action.	trentino	10-18	C-X-C motif chemokine ligand 8	Homo sapiens	94-107
17273783-0	2007	Comano"s (Trentino) thermal water interferes with tumour necrosis factor-alpha expression and interleukin-8 production and secretion by cultured human psoriatic keratinocytes: yet other mechanisms of its anti-psoriatic action.	Water	28-33	C-X-C motif chemokine ligand 8	Homo sapiens	94-107
17008880-0	2007	Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane.	Ascorbic Acid	88-97	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
17314256-6	2007	Furthermore, human monocytes stimulated by water-insoluble alpha-glucans produced TNF-alpha and IL-8, while human polymorphonuclear cells were activated by water-insoluble alpha-glucans, resulting in chemotaxis and hydrogen peroxide production.	Water	43-48	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
17314256-6	2007	Furthermore, human monocytes stimulated by water-insoluble alpha-glucans produced TNF-alpha and IL-8, while human polymorphonuclear cells were activated by water-insoluble alpha-glucans, resulting in chemotaxis and hydrogen peroxide production.	alpha-glucans	59-72	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
17454250-4	2007	MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) cell viability decreased significantly (p &lt; .05) from 0.00005 to 0.05 mg/ml after 24 h. The proinflammatory mediators of inflammation cytokines interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-alpha, IL-10, and IL-1beta were also assessed.	monooxyethylene trimethylolpropane tristearate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	234-238
17454250-4	2007	MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) cell viability decreased significantly (p &lt; .05) from 0.00005 to 0.05 mg/ml after 24 h. The proinflammatory mediators of inflammation cytokines interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-alpha, IL-10, and IL-1beta were also assessed.	thiazolyl blue	5-65	C-X-C motif chemokine ligand 8	Homo sapiens	234-238
17008880-7	2007	In addition, increased IL-8 and MCP-1 mRNA expressions were suppressed by vitamin C treatment.	Ascorbic Acid	74-83	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
17008880-9	2007	Taken together, vitamin C uptake is increased in UVB-irradiated keratinocytes through the translocation of SVCT-1 and regulates inflammatory response in the skin via the downregulation of IL-8 and MCP-1 production.	Ascorbic Acid	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
17039239-3	2007	Notably, extracellular ATP displayed a complex regulation of IFN-gamma-stimulated chemokine expression, with upregulation of CC chemokine ligand 2 (CCL2), CCL5 and CXC chemokine ligand 8 (CXCL8), and suppression of the receptor CXC chemokine receptor 3 (CXCR3), CXCL9, CXCL10, and CXCL11.	Adenosine Triphosphate	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	164-186
17130184-9	2007	The inhibitors of PI-3K wortmannin and LY294002 inhibited the chemotaxis and suppressed IL-8-evoked dephosphorylation and rephosphorylation of cofilin.	Wortmannin	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
17039239-3	2007	Notably, extracellular ATP displayed a complex regulation of IFN-gamma-stimulated chemokine expression, with upregulation of CC chemokine ligand 2 (CCL2), CCL5 and CXC chemokine ligand 8 (CXCL8), and suppression of the receptor CXC chemokine receptor 3 (CXCR3), CXCL9, CXCL10, and CXCL11.	Adenosine Triphosphate	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	188-193
17130184-9	2007	The inhibitors of PI-3K wortmannin and LY294002 inhibited the chemotaxis and suppressed IL-8-evoked dephosphorylation and rephosphorylation of cofilin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
17332609-2	2007	Previous studies with various animal models showed that (99m)Tc-labeled IL-8 accumulates specifically and rapidly in infectious and inflammatory foci.	Technetium	61-63	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
17043099-4	2007	RESULTS: Polyriboinosinic:polyribocytidylic acid (poly I:C), a synthetic dsRNA that antagonizes TLR3, stimulated the secretion of IL-6, IL-8 and GCP-2 by OECs.	Poly I-C	9-48	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
17081611-8	2007	Parotid saliva augmented IL-8 production of THP-1 cells stimulated with a synthetic TLR2 ligand, Pam(3)Cys-Ser-(Lys)(4) (Pam(3)CSK(4)).	Cysteine	103-106	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
17081611-8	2007	Parotid saliva augmented IL-8 production of THP-1 cells stimulated with a synthetic TLR2 ligand, Pam(3)Cys-Ser-(Lys)(4) (Pam(3)CSK(4)).	Serine	107-110	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
17081611-8	2007	Parotid saliva augmented IL-8 production of THP-1 cells stimulated with a synthetic TLR2 ligand, Pam(3)Cys-Ser-(Lys)(4) (Pam(3)CSK(4)).	Lysine	112-115	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
17182620-1	2007	Activation of CD38 in lymphokine-activated killer (LAK) cells involves interleukin-8 (IL8)-mediated protein kinase G (PKG) activation and results in an increase in the sustained intracellular Ca(2+) concentration ([Ca(2+)](i)), cADP-ribose, and LAK cell migration.	Cyclic ADP-Ribose	228-239	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
17182620-1	2007	Activation of CD38 in lymphokine-activated killer (LAK) cells involves interleukin-8 (IL8)-mediated protein kinase G (PKG) activation and results in an increase in the sustained intracellular Ca(2+) concentration ([Ca(2+)](i)), cADP-ribose, and LAK cell migration.	Cyclic ADP-Ribose	228-239	C-X-C motif chemokine ligand 8	Homo sapiens	86-89
17182620-6	2007	Supporting these observations, IL8- or cell-permeable cGMP analog-induced formation of cADP-ribose, increase in [Ca(2+)](i), and migration of LAK cells were inhibited by treatment with the MHCIIA inhibitor blebbistatin.	Cyclic GMP	54-58	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
17182620-6	2007	Supporting these observations, IL8- or cell-permeable cGMP analog-induced formation of cADP-ribose, increase in [Ca(2+)](i), and migration of LAK cells were inhibited by treatment with the MHCIIA inhibitor blebbistatin.	Cyclic ADP-Ribose	87-98	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
17182620-6	2007	Supporting these observations, IL8- or cell-permeable cGMP analog-induced formation of cADP-ribose, increase in [Ca(2+)](i), and migration of LAK cells were inhibited by treatment with the MHCIIA inhibitor blebbistatin.	blebbistatin	206-218	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
17301742-3	2007	claim that Naf-BBL--a naphthylalanine-labelled, truncated version of this domain--folds in this way, on the grounds that they recorded a wide spread of melting temperatures of individual atoms measured by proton nuclear magnetic resonance (NMR) during their thermal denaturation.	naphthylalanine	22-37	C-X-C motif chemokine ligand 8	Homo sapiens	11-14
17301743-3	2007	claim that the small re-engineered protein Naf-BBL unfolds without significant cooperativity or kinetic hindrance, a conclusion that is based on calculation of a broad distribution of midpoint thermal-transition temperatures measured by the nuclear magnetic resonance (NMR) chemical shifts of 158 protons.	N-Carbobenzyloxy-L-alanine	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
16928771-0	2007	Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB.	lysophosphatidic acid	27-48	C-X-C motif chemokine ligand 8	Homo sapiens	57-70
16928771-1	2007	The signaling pathways mediating lysophosphatidic acid (LPA)-stimulated PKD(2) activation and the potential contribution of PKD(2) in regulating LPA-induced interleukin 8 (IL-8) secretion in nontransformed, human colonic epithelial NCM460 cells were examined.	lysophosphatidic acid	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	157-170
16928771-1	2007	The signaling pathways mediating lysophosphatidic acid (LPA)-stimulated PKD(2) activation and the potential contribution of PKD(2) in regulating LPA-induced interleukin 8 (IL-8) secretion in nontransformed, human colonic epithelial NCM460 cells were examined.	lysophosphatidic acid	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
16928771-1	2007	The signaling pathways mediating lysophosphatidic acid (LPA)-stimulated PKD(2) activation and the potential contribution of PKD(2) in regulating LPA-induced interleukin 8 (IL-8) secretion in nontransformed, human colonic epithelial NCM460 cells were examined.	lysophosphatidic acid	145-148	C-X-C motif chemokine ligand 8	Homo sapiens	157-170
16928771-1	2007	The signaling pathways mediating lysophosphatidic acid (LPA)-stimulated PKD(2) activation and the potential contribution of PKD(2) in regulating LPA-induced interleukin 8 (IL-8) secretion in nontransformed, human colonic epithelial NCM460 cells were examined.	lysophosphatidic acid	145-148	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
16928771-5	2007	LPA induced a striking increase in IL-8 production and stimulated NF-kappaB activation, as measured by NF-kappaB-DNA binding, NF-kappaB-driven luciferase reporter activity, and IkappaBalpha phosphorylation.	lysophosphatidic acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
16928771-7	2007	PKD(2) activation is a novel early event in the biological action of LPA and mediates LPA-stimulated IL-8 secretion in NCM460 cells through a NF-kappaB-dependent pathway.	lysophosphatidic acid	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
17169865-2	2007	We have recently reported that early changes in NO2-exposed human bronchial epithelial cells are causally linked to increased generation of proinflammatory mediators, such as nitric oxide/nitrite and cytokines like interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and IL-8.	Nitrogen Dioxide	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	277-281
17227815-5	2007	Pretreatment of cervical stromal cells with inhibitors of RhoA (C3 transferase exoenzyme), Rho-kinase (Y-27632) or NF-kB (BAY11-7082) effectively blocked LPS-induced IL-8 release.	3-(4-methylphenylsulfonyl)-2-propenenitrile	122-132	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
17227815-6	2007	In contrast, IL-1beta-induced IL-8 production was significantly blocked by BAY11-7082, but not by C3 transferase exoenzyme or Y-27632.	3-(4-methylphenylsulfonyl)-2-propenenitrile	75-85	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
17326846-2	2007	This study measured cytotoxicity and the release of the proinflammatory cytokines IL-6 and IL-8 by human bronchial epithelial cells treated with manufactured nano- and micron-sized particles of Al2O3, CeO2, Fe2O3, NiO, SiO2, and TiO2, with soil-derived particles from fugitive dust sources, and with the positive controls LPS, TNF-alpha, and VOSO4.	Aluminum Oxide	194-199	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
17277122-7	2007	Human immature dendritic cells (DCs) cultured in the presence of c-di-GMP showed increased expression of costimulatory molecules CD80/CD86 and maturation marker CD83, increased MHC class II and cytokines and chemokines such as IL-12, IFN-gamma, IL-8, MCP-1, IFN-gamma-inducible protein 10, and RANTES, and altered expression of chemokine receptors including CCR1, CCR7, and CXCR4.	bis(3',5')-cyclic diguanylic acid	65-73	C-X-C motif chemokine ligand 8	Homo sapiens	245-249
17178391-8	2007	Selective inhibitors of p38(mapk) (SB203580) or of MEK1/2, the direct upstream activator of ERK1/2 (PD98059), reduced the synthesis of IL-1beta, TNFalpha, IL-6 and IL-8 induced by either the chaperonins or LPS.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	100-107	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
17043099-4	2007	RESULTS: Polyriboinosinic:polyribocytidylic acid (poly I:C), a synthetic dsRNA that antagonizes TLR3, stimulated the secretion of IL-6, IL-8 and GCP-2 by OECs.	Poly I-C	50-58	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
17203209-2	2007	Recently, increase in interleukin (IL)-8 in the esophageal mucosa has been associated with the pathogenesis of esophagitis induced by reflux of gastric acids, bile acids or trypsin.	Bile Acids and Salts	159-169	C-X-C motif chemokine ligand 8	Homo sapiens	22-40
17289483-10	2007	DEX significantly reduced at least 1 postoperative level of IL-6, IL-8, IL-10, CRP, and exhaled NO.	Dexamethasone	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
17203209-5	2007	IL-8 was produced in a dose-dependent fashion when cells were stimulated with a PAR2 agonist such as trypsin or SLIGKV-amide.	Amides	119-124	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
17125827-10	2007	In contrast, histamine rapidly induced a Ca(2+) signal and stimulated IL-8 production in MDMs.	Histamine	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
17121804-0	2007	Rhinovirus activates interleukin-8 expression via a Src/p110beta phosphatidylinositol 3-kinase/Akt pathway in human airway epithelial cells.	Phosphatidylinositols	65-85	C-X-C motif chemokine ligand 8	Homo sapiens	21-34
17237377-5	2007	We also show that HP-NAP stimulates human PMNs to synthesize and release a number of chemokines, including CXCL8, CCL3, and CCL4.	hp-nap	18-24	C-X-C motif chemokine ligand 8	Homo sapiens	107-112
17237435-6	2007	Prednisolone dose-dependently inhibited the LPS-induced release of cytokines (TNF-alpha and IL-6) and chemokines (IL-8 and MCP-1), while enhancing the release of the anti-inflammatory cytokine IL-10.	Prednisolone	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
17108260-4	2007	These genes were also found to be NF-kappaB-dependent in that TNFalpha-induced expression of IL-6, IL-8, and eotaxin was dose-dependently inhibited by the selective IKKbeta inhibitor 4-(2"-aminoethyl)amino-1,8-dimethylimidazo[1,2-a]quinoxaline (BMS-345541) (1-30 microM).	4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline	183-243	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
16806476-0	2007	Saxatilin inhibits TNF-alpha-induced proliferation by suppressing AP-1-dependent IL-8 expression in the ovarian cancer cell line MDAH 2774.	saxatilin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
16806476-3	2007	TNF-alpha-induced IL-8 promoter activation that is inhibited by saxatilin treatment was dependent on activating protein-1 (AP-1) instead of nuclear factor-kappa B (NF-kappaB).	saxatilin	64-73	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
16806476-4	2007	Coexpression of dominant negative p38 (DN-p38) suggested that p38 is involved in the IL-8 promoter activity which is regulated by saxatilin or TNF-alpha.	saxatilin	130-139	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
16806476-5	2007	Experimental evidence clearly indicated that saxatilin inhibits TNF-alpha-induced proliferation of the ovarian cancer cells by suppressing IL-8 expression in AP-1-dependent manner.	saxatilin	45-54	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
16712933-8	2007	125I-labeled hIL-8 bound to gpCXCR1 and addition of unlabeled hIL-8 completely abolished the binding; however, unlabeled gpIL-8 failed to compete against 125I-labeled hIL-8, strongly suggesting that the avidity of hIL-8 to gpCXCR1 is higher than that of gpIL-8.	Iodine-125	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	13-18
16712933-8	2007	125I-labeled hIL-8 bound to gpCXCR1 and addition of unlabeled hIL-8 completely abolished the binding; however, unlabeled gpIL-8 failed to compete against 125I-labeled hIL-8, strongly suggesting that the avidity of hIL-8 to gpCXCR1 is higher than that of gpIL-8.	gpil-8	254-260	C-X-C motif chemokine ligand 8	Homo sapiens	13-18
17108260-4	2007	These genes were also found to be NF-kappaB-dependent in that TNFalpha-induced expression of IL-6, IL-8, and eotaxin was dose-dependently inhibited by the selective IKKbeta inhibitor 4-(2"-aminoethyl)amino-1,8-dimethylimidazo[1,2-a]quinoxaline (BMS-345541) (1-30 microM).	4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline	245-255	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
17286914-7	2007	The combination of TBP and TRBP was able to obviously inhibit both respiratory burst of monocytes induced by TNF-alpha and IFN-gamma and transcription level of IL-1beta and IL-8 mRNA induced by TNF-alpha.	trbp	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
17230585-5	2007	As compared to placebo fecal water, beta-glucan enriched fecal water significantly increased IL-8 production in HT29 (5.0%; p = 0.046) and INT407 cells (22.0%; p = 0.028).	beta-Glucans	36-47	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
17230585-5	2007	As compared to placebo fecal water, beta-glucan enriched fecal water significantly increased IL-8 production in HT29 (5.0%; p = 0.046) and INT407 cells (22.0%; p = 0.028).	Water	63-68	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
17224793-7	2007	The SA treatment also decreased cytomix-induced IL-6 and IL-8 production in a dose-dependent manner.	sodium arsenite	4-6	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
16862172-8	2007	Immunoblot analysis showed that pretreatment of NHBE cells with EGCG resulted in a significant downregulation of NF-kappaB-regulated proteins cyclin D1, MMP-9, IL-8 and iNOS.	epigallocatechin gallate	64-68	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
16942919-3	2007	Simvastatin treatment did not inhibit AgLDL-induced macrophage lipid accumulation, but significantly increased the secretion of IL-1beta and IL-8 from macrophages, whilst inhibiting the secretion of tumor necrosis factor-alpha (TNF-alpha) and having no significant effect on IL-6 secretion.	Simvastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
17113069-4	2007	Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P&lt;0.05).	Scopoletin	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
17113069-4	2007	Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P&lt;0.05).	Tetradecanoylphorbol Acetate	72-103	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
17113069-4	2007	Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P&lt;0.05).	Tetradecanoylphorbol Acetate	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
17113069-4	2007	Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P&lt;0.05).	Calcimycin	115-121	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
17113069-5	2007	The maximal rates at which scopoletin (0.2 mM) inhibited the production of TNF-alpha, IL-6, and IL-8 were 41.6%+/-4.2%, 71.9%+/-2.5%, and 43.0%+/-5.7%, respectively.	Scopoletin	27-37	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
16962273-0	2007	Inhibitory effect of flavonoid baicalin on degranulation of human polymorphonuclear leukocytes induced by interleukin-8: potential role in periodontal diseases.	Flavonoids	21-30	C-X-C motif chemokine ligand 8	Homo sapiens	106-119
16962273-0	2007	Inhibitory effect of flavonoid baicalin on degranulation of human polymorphonuclear leukocytes induced by interleukin-8: potential role in periodontal diseases.	baicalin	31-39	C-X-C motif chemokine ligand 8	Homo sapiens	106-119
16962273-2	2007	In the present study, we investigated whether baicalin could block polymorphonuclear leukocytes (PMNs) degranulation induced by interleukin (IL)-8, a CXC chemokine.	baicalin	46-54	C-X-C motif chemokine ligand 8	Homo sapiens	128-146
16962273-7	2007	The present study concludes that baicalin could block MMP-8 release from PMNs induced by IL-8, which suggests that it may play an important role in the prevention and treatment of periodontal disease.	baicalin	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
17202379-7	2007	Surprisingly, the TLR9 ligand CpG oligodeoxynucleotide 2006 was able to specifically inhibit poly(I:C)-induced IL-8 and IDO expression.	Poly I-C	93-102	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
17097222-0	2007	Sulfatide increases adiponectin and decreases TNF-alpha, IL-6, and IL-8 in human adipose tissue in vitro.	Sulfoglycosphingolipids	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
17097222-7	2007	The C16:0 sulfatide has been shown to activate potassium channels in beta-cells, and glibenclamide, an ATP-sensitive K+-(KATP) channel blocker, reversed the C16:0-induced decrement in stimulated TNF-alpha, IL-6, and IL-8 release in adipocytes.	Glyburide	85-98	C-X-C motif chemokine ligand 8	Homo sapiens	216-220
17061983-0	2007	Macrolides inhibit IL17-induced IL8 and 8-isoprostane release from human airway smooth muscle cells.	Macrolides	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
17097691-0	2007	Involvement of protein kinase Cdelta in iron chelator-induced IL-8 production in human intestinal epithelial cells.	Iron	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
17097691-1	2007	We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals, including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs) by activating ERK1/2 and p38 kinase pathways.	Iron	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
17097691-1	2007	We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals, including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs) by activating ERK1/2 and p38 kinase pathways.	Deferoxamine	48-60	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
17097691-1	2007	We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals, including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs) by activating ERK1/2 and p38 kinase pathways.	Deferoxamine	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
17097691-2	2007	In the present study, we show that PKCdelta, one of the novel protein kinase C (PKC) isoforms, involves in signal transduction pathways leading to DFO-induced IL-8 production.	Deferoxamine	147-150	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
17097691-3	2007	Pretreatment of human intestinal epithelial HT-29 cells with rottlerin showed remarkable inhibition of DFO-induced IL-8 production.	rottlerin	61-70	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
17097691-3	2007	Pretreatment of human intestinal epithelial HT-29 cells with rottlerin showed remarkable inhibition of DFO-induced IL-8 production.	Deferoxamine	103-106	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
17097691-7	2007	In addition, suppression of endogenous PKCdelta by siRNA significantly reduced DFO-induced IL-8 production.	Deferoxamine	79-82	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
17097691-8	2007	Collectively, these results suggest that PKCdelta plays a pivotal role in signaling pathways leading to iron chelator-induced IL-8 production in human IECs.	Iron	104-108	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
17012372-0	2007	Moxifloxacin but not ciprofloxacin or azithromycin selectively inhibits IL-8, IL-6, ERK1/2, JNK, and NF-kappaB activation in a cystic fibrosis epithelial cell line.	Moxifloxacin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
17012372-2	2007	We showed that moxifloxacin (MXF) inhibits IL-8 and MAPK activation in monocytic and respiratory epithelial cells.	Moxifloxacin	15-27	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
17012372-2	2007	We showed that moxifloxacin (MXF) inhibits IL-8 and MAPK activation in monocytic and respiratory epithelial cells.	Moxifloxacin	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
17184586-1	2007	AIM: To examine the inhibitive effects of triptolide on the expression of IL-8, monocyte chemotactic protein (MCP)-1, and matrix metalloproteinases (MMP)-3 in subepithelial myofibroblasts (SEMF) stimulated with IL-1beta.	triptolide	42-52	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
16905640-9	2007	Sulforaphane pretreatment inhibited IL-8 production by BEAS-2B cells upon stimulation with diesel extract.	sulforaphane	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
17061983-7	2007	IL17-induced IL8 production was decreased by both erythromycin and azithromycin.	Erythromycin	50-62	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
17061983-7	2007	IL17-induced IL8 production was decreased by both erythromycin and azithromycin.	Azithromycin	67-79	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
17061983-8	2007	In nonstimulated condition, IL8 production only increased at the highest dose of azithromycin.	Azithromycin	81-93	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
17061983-11	2007	We conclude that macrolides (but not steroids/immunosuppressive agents) inhibit IL17-induced IL8 production in human primary airway smooth muscle cells via a reduction in MAPK activation and 8-isoprostane production.	Macrolides	17-27	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
17430188-10	2007	We have found that carinosine (beta-Ala-His) suppressed the secretion of such inflammatory cytokines as IL-8 in human intestinal epithelial cells, suggesting its anti-inflammatory function in the intestines.	carinosine	19-29	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
18556829-5	2007	In order to determine the possible contribution of G protein, HUVEC were pretreated with an inhibitor of G-protein activation, GDPbetaS, which abrogated the low shear stress-induced IL-8 gene expression.	guanosine 5'-O-(2-thiodiphosphate)	127-135	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
18556829-8	2007	These findings therefore demonstrate the involvement of several signaling molecules, including tyrosine kinase, G protein, calcium, phospholipase C, and cAMP-dependent protein kinase, in the low shear stress-induced IL-8 gene expression.	Calcium	123-130	C-X-C motif chemokine ligand 8	Homo sapiens	216-220
16996047-0	2007	Effects of hyperbaric oxygen therapy on circulating interleukin-8, nitric oxide, and insulin-like growth factors in patients with type 2 diabetes mellitus.	Oxygen	22-28	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
16574124-8	2007	DHEA at the above mention concentration also inhibited the mRNA expression of MCP-1 and IL-8 in basal conditions but not in TNF-alpha-stimulated conditions.	Dehydroepiandrosterone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
17202660-2	2007	In this study, our aim was to examine the anti-inflammatory mechanism of TET through measuring the inducible nitric oxide synthase (iNOS), cyclooxygenase-1, and -2 (COX-1 and COX-2) expression, cytokines (TNF-alpha, IL-4 and IL-8) formation, nitric oxide (NO) release and prostaglandin E2 (PGE2) generation in lipopolysaccharide (LPS)-induced human monocytic (THP-1) cells.	tetrandrine	73-76	C-X-C motif chemokine ligand 8	Homo sapiens	225-229
18997280-5	2007	Here, we report that after differentiating THP-1 cells to macrophages, ritonavir treatment (10 microg/mL) significantly increases expression of proinflammatory cytokines, IL-6, MCP-1 and IL-8, at both mRNA and protein levels.	Ritonavir	71-80	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
17243915-4	2007	The aim of this study was to investigate whether plasma concentrations of interleukin-6, interleukin-8, C-reactive protein, and monocyte chemoattractant protein-1 are increased with higher plasma homocysteine concentrations and whether decreasing homocysteine by vitamin supplementation decreases the concentration of these markers.	Homocysteine	196-208	C-X-C motif chemokine ligand 8	Homo sapiens	89-102
17243915-6	2007	RESULTS: At baseline, plasma homocysteine concentration was weakly associated with interleukin-8, but not with interleukin-6, C-reactive protein or monocyte chemoattractant protein-1.	Homocysteine	29-41	C-X-C motif chemokine ligand 8	Homo sapiens	83-96
17243915-8	2007	CONCLUSIONS: At baseline homocysteine was only weakly correlated with interleukin-8, but not with interleukin-6, C-reactive protein or monocyte chemoattractant protein-1.	Homocysteine	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
17093102-0	2007	Binding of glucuronoxylomannan to the CD14 receptor in human A549 alveolar cells induces interleukin-8 production.	glucuronoxylomannan	11-30	C-X-C motif chemokine ligand 8	Homo sapiens	89-102
17093102-3	2007	In the current study, we demonstrate that GXM binds to the CD14 receptor in human type II alveolar epithelial cells, resulting in the production of the proinflammatory chemokine interleukin-8.	glucuronoxylomannan	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	178-191
17430188-10	2007	We have found that carinosine (beta-Ala-His) suppressed the secretion of such inflammatory cytokines as IL-8 in human intestinal epithelial cells, suggesting its anti-inflammatory function in the intestines.	2-(3-azaniumylpropanoylamino)-3-(1H-imidazol-5-yl)propanoate	31-43	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
17160716-0	2007	Phytic acid modulates in vitro IL-8 and IL-6 release from colonic epithelial cells stimulated with LPS and IL-1beta.	Phytic Acid	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
17391980-0	2007	Cadmium induces interleukin-8 production via NF-kappaB activation in the human intestinal epithelial cell, Caco-2.	Cadmium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	16-29
17391980-5	2007	The results of this assay demonstrated that the transcriptional activity of IL-8 was increased by CdCl2.	Cadmium Chloride	98-103	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
17391980-7	2007	Site-directed mutation of the NF-kappaB consensus element in the human IL-8 promoter abolished the increased transcriptional activity by CdCl2.	Cadmium Chloride	137-142	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
17391980-10	2007	Our results suggest that CdCl2 induced IL-8 secretion, its transcription, and its transcriptional activation regulated by NF-kappaB via I-kappaB alpha degradation.	Cadmium Chloride	25-30	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
17410895-0	2007	Effect of acetic NaF solutions on fluoride-containing dental restorative materials.	Fluorides	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
17410895-1	2007	The aim of this study was to evaluate the effect of acetic NaF solutions on fluoride-containing restorative materials.	Fluorides	76-84	C-X-C motif chemokine ligand 8	Homo sapiens	59-62
17160716-2	2007	The aim of this study was to examine the role of PA in immunologic function of intestinal epithelial cells by analyzing its effect on interleukin (IL)-8 and IL-6 secretion by colonocytes and its role in the response of these cells to bacterial lipopolysaccharides (LPS) and IL-1beta.	Phytic Acid	49-51	C-X-C motif chemokine ligand 8	Homo sapiens	134-152
17160716-5	2007	PA had a suppressive effect on IL-8 basal release and it dose dependently reduced IL-8 secretion by colonocytes stimulated with LPS and IL-1beta.	Phytic Acid	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
17160716-5	2007	PA had a suppressive effect on IL-8 basal release and it dose dependently reduced IL-8 secretion by colonocytes stimulated with LPS and IL-1beta.	Phytic Acid	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
17160716-8	2007	The ability of PA to modulate IL-8 and IL-6 release suggests that PA present in the intestinal milieu may exert immunoregulatory effects on colonic epithelium under physiological conditions or during microbe-induced infection/inflammation in order to maintain the colonic mucosa in a noninflammatory state or to counteract infection.	Phytic Acid	15-17	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
17160716-8	2007	The ability of PA to modulate IL-8 and IL-6 release suggests that PA present in the intestinal milieu may exert immunoregulatory effects on colonic epithelium under physiological conditions or during microbe-induced infection/inflammation in order to maintain the colonic mucosa in a noninflammatory state or to counteract infection.	Phytic Acid	66-68	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
17030560-2	2007	Interleukin-8 belongs to a subfamily of CXC chemokines containing a Glu-Leu-Arg (ELR) motif.	Glu-Leu-Arg	68-79	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
17050564-8	2007	There were significant decreases in plasma IL-4, IL-8 and eotaxin levels after 3 weeks of treatment with clarithromycin.	Clarithromycin	105-119	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
17849273-0	2007	Effect of hydrogen peroxide on interleukin-8 synthesis and death of Caco-2 cells.	Hydrogen Peroxide	10-27	C-X-C motif chemokine ligand 8	Homo sapiens	31-44
16709662-5	2007	The major CLPF-activating and IL8 inducing protein was purified using fast-performance liquid chromatography (HiPrep 16/60 Sephacryl S-200 High Resolution Column) and sodium dodecyl sulphate gel electrophoresis.	sephacryl s	123-134	C-X-C motif chemokine ligand 8	Homo sapiens	10-33
16709662-5	2007	The major CLPF-activating and IL8 inducing protein was purified using fast-performance liquid chromatography (HiPrep 16/60 Sephacryl S-200 High Resolution Column) and sodium dodecyl sulphate gel electrophoresis.	Sodium Dodecyl Sulfate	167-190	C-X-C motif chemokine ligand 8	Homo sapiens	10-33
17849273-3	2007	We investigated the time- and dose-dependent induction of IL-8 by hydrogen peroxide in the human colon adenocarcinoma cell line Caco-2.	Hydrogen Peroxide	66-83	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
17849273-8	2007	In nonfilter-grown Caco-2 cells, 1 mM of hydrogen peroxide induced the highest level of IL-8 production 24 hr after treatment.	Hydrogen Peroxide	41-58	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
17849273-9	2007	In filter-grown Caco-2 cells, IL-8 was produced only on the apical side in response to 1 mM of hydrogen peroxide.	Hydrogen Peroxide	95-112	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
17135765-0	2007	Epigallocatechin-3-gallate inhibits secretion of TNF-alpha, IL-6 and IL-8 through the attenuation of ERK and NF-kappaB in HMC-1 cells.	epigallocatechin gallate	0-26	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
17849273-11	2007	In filter-grown Caco-2 cells 10 mM hydrogen peroxide induced the highest IL-8 level on the apical as well as basolateral side.	Hydrogen Peroxide	35-52	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
17135765-2	2007	In the present study, we investigated the effect of EGCG on the secretion of TNF-alpha, IL-6 and IL-8, as well as its possible mechanism of action by using the human mast cell line (HMC-1).	epigallocatechin gallate	52-56	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
17541275-7	2007	On the contrary, only IL-8 induced the TBM of neutrophils.	metsulfuron methyl	39-42	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
17135765-5	2007	RESULTS: EGCG (100 microM) inhibited PMA+A23187-induced TNF-alpha, IL-6 and IL-8 expression and production.	epigallocatechin gallate	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
17135765-5	2007	RESULTS: EGCG (100 microM) inhibited PMA+A23187-induced TNF-alpha, IL-6 and IL-8 expression and production.	Calcimycin	41-47	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
17135765-8	2007	CONCLUSION: EGCG inhibited the production of TNF-alpha, IL-6 and IL-8 through the inhibition of the intracellular Ca(2+) level, and of ERK1/2 and NF-kappaB activation.	epigallocatechin gallate	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
17448722-5	2007	In parallel, a short-term (2h) cell exposure to AAT/LPS significantly enhances LPS-induced NF kappaB (p50 and p65) activation in conjunction with increased TNFalpha, IL-1 beta and IL-8 release.	Deuterium	27-29	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
17541276-9	2007	RESULTS: As previously reported, IL-8-stimulated neutrophils significantly augmented the TBM of eosinophils.	metsulfuron methyl	89-92	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
17541276-12	2007	Finally, theophylline attenuated the superoxide anion generation from IL-8-stimulated neutrophils on the Matrigel-coated plates.	Superoxides	37-53	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
17541276-12	2007	Finally, theophylline attenuated the superoxide anion generation from IL-8-stimulated neutrophils on the Matrigel-coated plates.	Theophylline	9-21	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
17541283-7	2007	Preincubation with 100 microM chloroquine significantly inhibited the expression of mRNA for RANTES, IP-10, and IL-8, stimulated by poly I:C, indicating that poly I:C may react with a receptor expressed inside the cells.	Chloroquine	30-41	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
17621557-6	2007	When added to human macrophage culture, rFC blocks the LPS-induced phosphorylation of p38, which, in turn, inhibits the consequential overexpression of TNF-alpha and IL-8.	lps	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
17886062-10	2007	BaP and Phe significantly enhanced cytokine secretion (IL-4, IL-8) and histamine release from purified basophils without antigen added, and secretion was not further enhanced by rBet v 1 stimulation.	Benzo(a)pyrene	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
17886062-10	2007	BaP and Phe significantly enhanced cytokine secretion (IL-4, IL-8) and histamine release from purified basophils without antigen added, and secretion was not further enhanced by rBet v 1 stimulation.	phenanthrene	8-11	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
17621556-3	2007	Here, we report that, at concentrations that did not induce whole blood cytokine production when tested separately, (1--&gt;3)-beta-D-glucans powerfully co-stimulated cytokine production (IL-6/IL-8) induced by ligands for TLR1/2, TLR2/6, TLR4, and TLR5.	beta-D-Glucan	127-141	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
17008886-8	2007	Nicotine significantly decreased IL-8 and -6 release by HMEC-1 maintained in both patients" and controls" sera, but only IL-6 release by keratinocytes maintained in patients" sera.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	33-44
17008886-11	2007	The phytoestrogen biochanin A alone and in combination with nicotine further decreased the secretion of IL-8, -6, and VEGF in all experimental settings.	Nicotine	60-68	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
17909718-8	2007	RESULTS: Postoperative plasma concentrations of IL-6 (days 1 and 2), IL-8 (days 2 and 3), and CRP (days 1-4) were significantly lower in the steroid than in the control group.	Steroids	141-148	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
16902417-7	2007	Only carboxylic acid-coated QDs significantly increased release of IL-1beta, IL-6, and IL-8.	Carboxylic Acids	5-20	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
17895603-7	2007	Furthermore, a mAb to the beta-glucan receptor, Dectin-1, significantly (P&lt;0.05) blocked the Sophy beta-glucan induced DNA synthesis in the PBMCs, and Sophy beta-glucan-induced production of IL-8 in the U937 cells.	beta-Glucans	26-37	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
18260853-10	2007	At the background of therapy with simvastatin we noted significant lowering of proinflammatory cytokines (TNFalpha, IL-1beta, IL-6, IL-8) in blood serum irrespective of level of low density lipoprotein cholesterol, betterment of functional state of the left ventricle, positive clinical dynamics of CHF.	Simvastatin	34-45	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
17135982-0	2007	Pneumococcal peptidoglycan-polysaccharides induce the expression of interleukin-8 in airway epithelial cells by way of nuclear factor-kappaB, nuclear factor interleukin-6, or activation protein-1 dependent mechanisms.	pneumococcal peptidoglycan-polysaccharides	0-42	C-X-C motif chemokine ligand 8	Homo sapiens	68-81
17135982-4	2007	However, the PGPS-induced IL-8 promoter activation in rodent middle ear epithelial cells required NF-kappaB and NF-IL6 but not AP-1.	pgps	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
17084411-12	2007	IL-6 levels were highest in patients with TRAM operations, being the most extensive procedure studied, whereas the highest IL-8 levels were seen in women with a saline filled silicone implant suggesting immunomodulation by foreign material.	Silicones	175-183	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
17551258-5	2007	Exogenous ADMA (30 microM) also increased ROS generation and the levels of TNF-alpha and IL-8, decreased the levels of nitrite/nitrate, upregulated CXCR2 gene expression, increased endothelial cell binding with monocytes and activated the NF-kappaB pathway, which was inhibited by pretreatment with losartan or L-arginine.	N,N-dimethylarginine	10-14	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
17710245-0	2007	Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) blocks the chemotaxis of neutrophils by inhibiting signal transduction through IL-8 receptors.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
17710245-0	2007	Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) blocks the chemotaxis of neutrophils by inhibiting signal transduction through IL-8 receptors.	1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione	10-69	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
17710245-2	2007	Chemotactic activity via human recombinant IL-8 (hrIL-8) was significantly inhibited by curcumin.	Curcumin	88-96	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
17710245-3	2007	Curcumin reduced calcium ion flow induced by internalization of the IL-8 receptor.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
17710245-3	2007	Curcumin reduced calcium ion flow induced by internalization of the IL-8 receptor.	Calcium	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
17710245-4	2007	We analyzed flow cytometry to evaluate the status of the IL-8 receptor after curcumin treatment.	Curcumin	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
17710245-7	2007	Following curcumin treatment, immunoprecipitation studies showed that the IL-8 receptor was associated with larger amounts of active Rab11 than that in control cells.	Curcumin	10-18	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
17710245-9	2007	The mechanism for antiinflammatory response by curcumin may involve unique regulation of the Rab11 trafficking molecule in recycling of IL-8 receptors.	Curcumin	47-55	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
17895603-8	2007	The Sophy beta-glucan-induced production of IL-8 in the U937 cells was significantly (P&lt;0.01) blocked by the conventional protein kinase C (PKC) inhibitor Go6976, the novel PKC inhibitor Rottlerin, the protein kinase A (PKA) inhibitor H-89, and the protein tyrosine kinase (PTK) inhibitor herbimycin A.	beta-Glucans	10-21	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
17895603-8	2007	The Sophy beta-glucan-induced production of IL-8 in the U937 cells was significantly (P&lt;0.01) blocked by the conventional protein kinase C (PKC) inhibitor Go6976, the novel PKC inhibitor Rottlerin, the protein kinase A (PKA) inhibitor H-89, and the protein tyrosine kinase (PTK) inhibitor herbimycin A.	Go 6976	158-164	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
17895603-8	2007	The Sophy beta-glucan-induced production of IL-8 in the U937 cells was significantly (P&lt;0.01) blocked by the conventional protein kinase C (PKC) inhibitor Go6976, the novel PKC inhibitor Rottlerin, the protein kinase A (PKA) inhibitor H-89, and the protein tyrosine kinase (PTK) inhibitor herbimycin A.	rottlerin	190-199	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
17895603-8	2007	The Sophy beta-glucan-induced production of IL-8 in the U937 cells was significantly (P&lt;0.01) blocked by the conventional protein kinase C (PKC) inhibitor Go6976, the novel PKC inhibitor Rottlerin, the protein kinase A (PKA) inhibitor H-89, and the protein tyrosine kinase (PTK) inhibitor herbimycin A.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	238-242	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
17895603-8	2007	The Sophy beta-glucan-induced production of IL-8 in the U937 cells was significantly (P&lt;0.01) blocked by the conventional protein kinase C (PKC) inhibitor Go6976, the novel PKC inhibitor Rottlerin, the protein kinase A (PKA) inhibitor H-89, and the protein tyrosine kinase (PTK) inhibitor herbimycin A.	herbimycin	292-304	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
17895603-10	2007	Studies employing reverse transcriptase-polymerase chain reaction (RT-PCR) showed that Sophy beta-glucan stimulated the expression of IL-8 mRNA in the U937 cells, and that this induction was inhibited by Rottlerin.	beta-Glucans	93-104	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
17895603-10	2007	Studies employing reverse transcriptase-polymerase chain reaction (RT-PCR) showed that Sophy beta-glucan stimulated the expression of IL-8 mRNA in the U937 cells, and that this induction was inhibited by Rottlerin.	rottlerin	204-213	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
17389814-8	2007	Equimolar doses of exogenous IL-10 or DEX produced up to 83% inhibition of IL-8 from PMNs.	Dexamethasone	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
17344653-8	2007	In the presence of 20 mM vitamin C, even a stronger stimulatory effect was noted for the percentage of IL-8 (e.g., 46.7% increase, p &lt; 0.001) and TNF-alpha producing neonatal monocytes (e.g., 69.2% increase, p = 0.004; n = 20).	Ascorbic Acid	25-34	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
17389814-9	2007	Exogenous IL-10 was more potent than DEX, on an equimolar basis, with regard to IL-8 release from PBMCs (90 vs. 33% respectively at a 10 nanomolar level).	Dexamethasone	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
17344660-6	2007	RESULTS: IL-8 mRNA levels were significantly increased in whole blood both during PA and PI, while MCP-1 mRNA levels were not.	Protactinium	82-84	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
17344663-0	2007	Perfluorocarbon suppresses lipopolysaccharide- and alpha-toxin-induced interleukin-8 release from alveolar epithelial cells.	Fluorocarbons	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
17079162-4	2007	Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells.	fisetin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
17079162-4	2007	Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells.	Tetradecanoylphorbol Acetate	18-49	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
17079162-4	2007	Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells.	Calcimycin	73-79	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
17079162-4	2007	Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells.	pmaci	81-86	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
16413994-7	2007	RESULTS: Forced vital capacity was increased and sputum IL-8 levels decreased after 4 weeks of theophylline treatment.	Theophylline	95-107	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
16413994-9	2007	Levels of IL-8 and TNF-alpha released by LPS-stimulated THP-1 cells were reduced by treatment with theophylline at 10microg/ml.	Theophylline	99-111	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
16413994-0	2007	Long-term treatment with theophylline reduces neutrophils, interleukin-8 and tumor necrosis factor-alpha in the sputum of patients with chronic obstructive pulmonary disease.	Theophylline	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	59-104
16413994-10	2007	In contrast, IL-8 levels released by LPS-stimulated neutrophils were reduced by treatment with theophylline at 100microg/ml.	Theophylline	95-107	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
16530440-1	2007	Anti-inflammatory effect of desloratadine (DL), including, but not limited to depression of production of IL-4, IL-6 and IL-8, has been shown in several in vitro experiments but only a few in vivo studies refer to this findings.	desloratadine	28-41	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
16530440-1	2007	Anti-inflammatory effect of desloratadine (DL), including, but not limited to depression of production of IL-4, IL-6 and IL-8, has been shown in several in vitro experiments but only a few in vivo studies refer to this findings.	desloratadine	43-45	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
17172977-7	2007	The addition of NaCl lowered the production of IL-8, TNF-alpha, and IL-1 receptor antagonist by neutrophils, and IL-8 and IL-1beta by mononuclear cells stimulated with LPS.	Sodium Chloride	16-20	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
17268170-6	2007	This IL-8 release was abolished by treatment with intracellular Ca(2+) chelator (BAPTA-AM), but not by EGTA or nifedipine.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
17268170-7	2007	Calmodulin inhibitor (calmidazolium) and tyrosine kinase inhibitor (genistein) almost completely blocked IL-8 release by HDM.	calmidazolium	22-35	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
17268170-7	2007	Calmodulin inhibitor (calmidazolium) and tyrosine kinase inhibitor (genistein) almost completely blocked IL-8 release by HDM.	Genistein	68-77	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
17268170-8	2007	PD98,059, an ERK pathway inhibitor, completely abolished HDM-induced IL-8 release.	pd98,059	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
17202889-9	2007	CONCLUSION: TNF-alpha and IL-8 stimulation up-regulated the FAK expression of human nucleus pulposus cells, and the coadministration of dexamethasone attenuated it.	Dexamethasone	136-149	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
17172977-7	2007	The addition of NaCl lowered the production of IL-8, TNF-alpha, and IL-1 receptor antagonist by neutrophils, and IL-8 and IL-1beta by mononuclear cells stimulated with LPS.	Sodium Chloride	16-20	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
17165981-7	2006	The best photoactive films were obtained from poly(ethylene glycol) (PEG 400) containing NH4F for TiO2 and from aqueous NaF for WO3.	wo3	128-131	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
16682428-9	2006	RESULTS: A positive correlation was identified between MCS grade, histological grade (p = 0.001) and mucosal IL8 activity (p&lt;0.001).	mcs	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	109-112
17384268-5	2006	IL-8 and caspase-3 activation were both influenced by paxilline, an inhibitor of calcium-activated potassium channels.	paxilline	54-63	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
17045242-3	2006	AZM reduced about 40% of IL-8 mRNA and protein expression (n=9, p=0.02, and n=4, p=0.00011) in CF cells reaching the levels of non-CF cells.	Azithromycin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
16937109-8	2006	Fluoride plaque concentrations evaluated in 12 individuals after (1) application of the active gel, (2) rinsing with 0.2% NaF, and (3) rinsing with water showed significantly higher values after rinsing with the NaF solution.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	122-125
16937109-8	2006	Fluoride plaque concentrations evaluated in 12 individuals after (1) application of the active gel, (2) rinsing with 0.2% NaF, and (3) rinsing with water showed significantly higher values after rinsing with the NaF solution.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	212-215
17078003-0	2006	Involvement of cyclooxygenase-2--prostaglandin E2 pathway in interleukin-8 production in gastric cancer cells.	Dinoprostone	33-49	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
17078003-2	2006	The effect of PGE(2) on the proinflammatory chemokine interleukin-8 (IL-8) in the gastric epithelial cells has not been defined yet.	Prostaglandins E	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
17078003-2	2006	The effect of PGE(2) on the proinflammatory chemokine interleukin-8 (IL-8) in the gastric epithelial cells has not been defined yet.	Prostaglandins E	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
16300955-7	2006	Recently we reported on the radioiodination of interleukin-8 (IL-8) using the pyridine carboxylate-derived activated ester.	pyridine carboxylate-derived activated ester	78-122	C-X-C motif chemokine ligand 8	Homo sapiens	47-60
16300955-7	2006	Recently we reported on the radioiodination of interleukin-8 (IL-8) using the pyridine carboxylate-derived activated ester.	pyridine carboxylate-derived activated ester	78-122	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
16628233-3	2006	Treatment of HeLa cells with apicidin increases transcriptional activity of NF-kappaB and its target gene IL-8 and cIAP-1 induction, which involves the activation of IKK-IkappaBalpha signaling pathway through Sp1-dependent de novo protein synthesis.	apicidin	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
16628233-4	2006	In parallel, apicidin treatment leads to histone hyperacetylation in the IL-8 promoter region independent of NF-kappaB signaling pathway, which is not sufficient for full transcription of IL-8 gene.	apicidin	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
17078003-12	2006	PGE(2)-induced IL-8 production was inhibited by pretreatment with EP2 and EP4 antagonists.	Dinoprostone	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
17078003-14	2006	The amount of IL-8 antigen increased slightly, but not significantly, with arachidonic acid treatment.	Arachidonic Acid	75-91	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
17078003-16	2006	These results suggest that the COX-2-PGE(2) pathway may be involved in IL-8 production in gastric epithelial cells.	Prostaglandins E	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
16682428-12	2006	CONCLUSION: MCS grading is associated with the degree of histological inflammation and mucosal IL8 activity in patients with quiescent ulcerative colitis, and may predict the probability of subsequent disease relapse in patients with ulcerative colitis in remission.	mcs	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
17269555-5	2006	DHA and CLA significantly decreased the production of IL-8 in response to stimulation by TNF-alpha [2907 +/- 970 (DHA) and 6471 +/- 1203 (CLA) vs. 12,287 +/- 2309 (control) pg/mL; P &lt; or = 0.05, mean +/- SEM], whereas both EPA and DHA reduced histamine-stimulated RANTES (regulation on activation, T cell-expressed and -secreted) production [2314 +/- 861 (EPA) and 877 +/- 326 (DHA) vs. 8526 +/- 1118 (control) pg/mL; P &lt; or = 0.03].	dehydroacetic acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
17082725-6	2006	In comparison with cells from controls, PMNs obtained from patients before starting simvastatin treatment showed higher resting and fMLP-stimulated IL-8 release (P = 0.007 and P = 0.002, respectively) and ROS generation (resting, P = 0.009; and fMLP-stimulated, P = 0.046), whereas migration and the chemotactic index did not significantly differ.	Simvastatin	84-95	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
17269555-5	2006	DHA and CLA significantly decreased the production of IL-8 in response to stimulation by TNF-alpha [2907 +/- 970 (DHA) and 6471 +/- 1203 (CLA) vs. 12,287 +/- 2309 (control) pg/mL; P &lt; or = 0.05, mean +/- SEM], whereas both EPA and DHA reduced histamine-stimulated RANTES (regulation on activation, T cell-expressed and -secreted) production [2314 +/- 861 (EPA) and 877 +/- 326 (DHA) vs. 8526 +/- 1118 (control) pg/mL; P &lt; or = 0.03].	dehydroacetic acid	114-117	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
16988013-2	2006	In A549 pulmonary cells, dexamethasone and the prototypical dissociated ligand RU24858 (Mol Endocrinol 11:1245-1255, 1997) repress interleukin (IL)-1beta-induced expression of cyclooxygenase (COX)-2 and IL-8.	Dexamethasone	25-38	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
17269555-5	2006	DHA and CLA significantly decreased the production of IL-8 in response to stimulation by TNF-alpha [2907 +/- 970 (DHA) and 6471 +/- 1203 (CLA) vs. 12,287 +/- 2309 (control) pg/mL; P &lt; or = 0.05, mean +/- SEM], whereas both EPA and DHA reduced histamine-stimulated RANTES (regulation on activation, T cell-expressed and -secreted) production [2314 +/- 861 (EPA) and 877 +/- 326 (DHA) vs. 8526 +/- 1118 (control) pg/mL; P &lt; or = 0.03].	dehydroacetic acid	114-117	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
17269555-5	2006	DHA and CLA significantly decreased the production of IL-8 in response to stimulation by TNF-alpha [2907 +/- 970 (DHA) and 6471 +/- 1203 (CLA) vs. 12,287 +/- 2309 (control) pg/mL; P &lt; or = 0.05, mean +/- SEM], whereas both EPA and DHA reduced histamine-stimulated RANTES (regulation on activation, T cell-expressed and -secreted) production [2314 +/- 861 (EPA) and 877 +/- 326 (DHA) vs. 8526 +/- 1118 (control) pg/mL; P &lt; or = 0.03].	Histamine	246-255	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
17269555-5	2006	DHA and CLA significantly decreased the production of IL-8 in response to stimulation by TNF-alpha [2907 +/- 970 (DHA) and 6471 +/- 1203 (CLA) vs. 12,287 +/- 2309 (control) pg/mL; P &lt; or = 0.05, mean +/- SEM], whereas both EPA and DHA reduced histamine-stimulated RANTES (regulation on activation, T cell-expressed and -secreted) production [2314 +/- 861 (EPA) and 877 +/- 326 (DHA) vs. 8526 +/- 1118 (control) pg/mL; P &lt; or = 0.03].	dehydroacetic acid	114-117	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
16988013-2	2006	In A549 pulmonary cells, dexamethasone and the prototypical dissociated ligand RU24858 (Mol Endocrinol 11:1245-1255, 1997) repress interleukin (IL)-1beta-induced expression of cyclooxygenase (COX)-2 and IL-8.	RU24858	79-86	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
16988013-6	2006	Analysis of IL-1beta-induced steady-state mRNA levels for IL-8 and COX-2 show that dexamethasone- and RU24858-dependent repression of these genes is attenuated by inhibitors of transcription and protein synthesis.	Dexamethasone	83-96	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
17172406-3	2006	Bortezomib synergized with IFN-alpha to promote apoptosis via a tumor necrosis factor-related apoptosis-inducing ligand-associated mechanism but did not inhibit production of proangiogenic factors (vascular endothelial growth factor, basic fibroblast growth factor, and interleukin-8) in human UM-UC-5 cells.	Bortezomib	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	270-283
17083726-9	2006	High sputum IL-8 and IL-17A mRNA levels were also found in moderate-to-severe (persistent) asthmatics on inhaled steroid treatment.	Steroids	113-120	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
17089061-12	2006	DSS induced the weak release of IL-8, IL-6, and TGF-beta1.	Dextran Sulfate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
17082639-0	2006	A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells.	cobaltous chloride	44-59	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
17082639-3	2006	In this study, we used human pulmonary microvascular endothelial cells and human dermal microvascular endothelial immortalized cell line to delineate the cellular signaling mechanism of hypoxia- and CoCl2 (a mimetic of hypoxia)-induced IL-8 expression, and the latter"s role in chemotaxis of polmorphonuclear neutrophils.	cobaltous chloride	199-204	C-X-C motif chemokine ligand 8	Homo sapiens	236-240
17082639-4	2006	We show that hypoxia- and CoCl2-induced IL-8 mRNA and protein expression involved activation of PI3K/Akt and p38 MAPK, but not MEK kinase.	cobaltous chloride	26-31	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
17082639-5	2006	Analysis of some transcription factors associated with IL-8 promoter revealed that hypoxia and CoCl2 increased DNA-binding activity of hypoxia-inducible factor-1alpha (HIF-1alpha), NF-kappaB, and AP-1.	cobaltous chloride	95-100	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
16997914-7	2006	Disruption of Hx8 by deletion or mutation distorts an H-bonding network, involving highly conserved amino acids within TM2, TM7, and Hx8, that is crucial for positioning of the TM domains, coupling to Galphaq, and CXCL8 binding.	galphaq	201-208	C-X-C motif chemokine ligand 8	Homo sapiens	214-219
16822944-4	2006	The aim of this study was to determine whether human ASMC (HASMC) express functional IL-8 receptors (CXCR1 and CXCR2) linked to cell contraction and migration.	asmc	53-57	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
16794257-3	2006	Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells.	Quercetin	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
16794257-3	2006	Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
16822944-4	2006	The aim of this study was to determine whether human ASMC (HASMC) express functional IL-8 receptors (CXCR1 and CXCR2) linked to cell contraction and migration.	hasmc	59-64	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
16822944-9	2006	IL-8 also contracted the HASMC, decreasing the length of cells by 15%, and induced a 2.5-fold increase in migration.	hasmc	25-30	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
16979119-6	2006	Clinically relevant concentrations of fenretinide (1.25, 2.5 and 5 microM) inhibited TNF-alpha-induced IL-8 production of CF cells by up to 73% but had no effect or increased the IL-8 production in non-CF cells.	Fenretinide	38-49	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
16947006-5	2006	NaF was used to leach the Al(3+) ion from the MIP.	ALUMINUM ION	26-32	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
16931790-5	2006	Using the UPR inducing agent tunicamycin and selective siRNA targeting of the ATF4 and XBP1 branches of the UPR, we demonstrate that these transcription factors are essential mediators of IL8, IL6, and MCP1 expression in human aortic ECs required for maximal inflammatory gene expression in the basal state and after oxPAPC treatment.	Tunicamycin	29-40	C-X-C motif chemokine ligand 8	Homo sapiens	188-191
16931790-5	2006	Using the UPR inducing agent tunicamycin and selective siRNA targeting of the ATF4 and XBP1 branches of the UPR, we demonstrate that these transcription factors are essential mediators of IL8, IL6, and MCP1 expression in human aortic ECs required for maximal inflammatory gene expression in the basal state and after oxPAPC treatment.	oxpapc	317-323	C-X-C motif chemokine ligand 8	Homo sapiens	188-191
17077523-6	2006	We showed that GJWGM inhibited the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-6, and IL-8 induced by LPS in dose dependent manner (p&lt;0.05).	gjwgm	15-20	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
16849637-9	2006	Treatment of control neutrophils with cytokines and lipopolysaccharide (LPS) to mimic endogenous septic environment inhibited actin polymerization and tyrosine phosphorylation in response to IL-8 or LTB4.	Tyrosine	151-159	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
16979119-0	2006	Inhibition of IL-8 release from CFTR-deficient lung epithelial cells following pre-treatment with fenretinide.	Fenretinide	98-109	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
16979119-7	2006	Although fenretinide treatment was associated with a higher intracellular ceramide content in the mutant DeltaF508 CFTR cells, the fenretinide-mediated decrease in IL-8 secretion was not consistently explained by changes in the intracellular content of this sphingolipid.	Fenretinide	131-142	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
17122965-2	2006	In this study, we investigated the anti-inflammatory actions beyond the suppression of acid secretion by proton pump inhibitors (PPI), such as omeprazole and lansoprazole, on IL-8 production by gastric epithelial cells (MKN45) and human umbilical vein endothelial cells (HUVEC) and on the transendothelial migration of polymorphonuclear neutrophils (PMN).	Omeprazole	143-153	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
16979119-9	2006	The fenretinide mediated decrease in IL-8 release in CF cells under TNF-alpha stimulated conditions presents the possibility that the lung inflammation in CF could be attenuated via low dose fenretinide treatment.	Fenretinide	4-15	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
17122965-2	2006	In this study, we investigated the anti-inflammatory actions beyond the suppression of acid secretion by proton pump inhibitors (PPI), such as omeprazole and lansoprazole, on IL-8 production by gastric epithelial cells (MKN45) and human umbilical vein endothelial cells (HUVEC) and on the transendothelial migration of polymorphonuclear neutrophils (PMN).	Lansoprazole	158-170	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
17203778-1	2006	Whether or not water pressure enhances the cytotoxic activity of sodium fluoride (NaF) against human periodontal ligament fibroblast (HPLF) was investigated.	Sodium Fluoride	65-80	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
17203778-2	2006	Loading with water pressure (up to 5 g) alone did not affect the cell proliferation, but significantly enhanced the cytotoxic activity of millimolar concentrations of NaF.	Water	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	167-170
17203778-4	2006	However, the enhancement of cytotoxicity of NaF under water pressure was observed even in the Ca2+ -free medium.	Water	54-59	C-X-C motif chemokine ligand 8	Homo sapiens	44-47
16979119-9	2006	The fenretinide mediated decrease in IL-8 release in CF cells under TNF-alpha stimulated conditions presents the possibility that the lung inflammation in CF could be attenuated via low dose fenretinide treatment.	Fenretinide	191-202	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
17063122-6	2006	After activation with polyinosinic-polycytidylic acid, BDCs expressed higher levels of major histocompatibility complex class I, CD40, CD80, and CD83, and secreted higher levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-8 compared with MoDCs.	Poly I-C	22-53	C-X-C motif chemokine ligand 8	Homo sapiens	244-248
16795034-0	2006	Lysophospholipids increase IL-8 and MCP-1 expressions in human umbilical cord vein endothelial cells through an IL-1-dependent mechanism.	Lysophospholipids	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
16965524-8	2006	IL-1alpha, IL-1beta and IL-8, but not IL-6, were detected in GCF of CsA-treated patients, but none of them was significantly associated with gingival overgrowth.	Cyclosporine	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
17063122-6	2006	After activation with polyinosinic-polycytidylic acid, BDCs expressed higher levels of major histocompatibility complex class I, CD40, CD80, and CD83, and secreted higher levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-8 compared with MoDCs.	tert-butyldimethylsilyl chloride	55-59	C-X-C motif chemokine ligand 8	Homo sapiens	244-248
16890260-8	2006	Furthermore, AEMD attenuated the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-8 and IL-6 secretion in human mast cells.	Tetradecanoylphorbol Acetate	33-64	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
17086464-5	2006	The preadministration of TJ-41 significantly inhibited increases in the serum level of keratinocyte chemoattractant (KC), which is a murine chemotaxin for neutrophils that corresponds to human interleukin-8, with respect to its concentration at 24 h after LPS challenge.	tj-41	25-30	C-X-C motif chemokine ligand 8	Homo sapiens	193-206
16890260-8	2006	Furthermore, AEMD attenuated the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-8 and IL-6 secretion in human mast cells.	Calcium	75-82	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
16890260-8	2006	Furthermore, AEMD attenuated the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-8 and IL-6 secretion in human mast cells.	Calcimycin	93-99	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
16919250-9	2006	We conclude that human NT2-N neurons release IL-8 and MCP-1 during 21 h of reoxygenation after 3 h of hypoxia.	nt2-n	23-28	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
17047652-11	2006	Moxifloxacin completely blocked the enhanced release of IL-8 induced by 0.5 and 1 microg ml(-1) VP-16, and decreased IL-8 release from cells incubated for 72 h with 3 microg ml(-1) VP-16 (P&lt;0.001).	Moxifloxacin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
17047652-11	2006	Moxifloxacin completely blocked the enhanced release of IL-8 induced by 0.5 and 1 microg ml(-1) VP-16, and decreased IL-8 release from cells incubated for 72 h with 3 microg ml(-1) VP-16 (P&lt;0.001).	Moxifloxacin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
16963169-0	2006	Mechanisms of silica-induced IL-8 release from A549 cells: initial kinase-activation does not require EGFR activation or particle uptake.	Silicon Dioxide	14-20	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
16806458-3	2006	Results indicate that a number of the primary carbon/resin materials demonstrate efficient adsorption of the cytokines studied here (TNF, IL-6 and IL-8), comparable to other adsorbents under clinical investigation.	Resins, Plant	53-58	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
16963169-8	2006	The EGFR inhibitor AG1478 attenuated both silica-induced IL-8 release and phosphorylation of SFKs and ERK1/2.	RTKI cpd	19-25	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
16963169-8	2006	The EGFR inhibitor AG1478 attenuated both silica-induced IL-8 release and phosphorylation of SFKs and ERK1/2.	Silicon Dioxide	42-48	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
17093399-3	2006	RESULTS: Vitreous and serum concentrations of IL-8, VEGF, and ANG determined by CBA showed a strong correlation with those measured by ELISA.	cba	80-83	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
17093399-7	2006	Measurements obtained by ELISA and CBA technologies were highly correlated for IL-8, VEGF, and ANG in both vitreous and serum samples.	cba	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
17093399-11	2006	CBA technology is a new, accurate method to measure IL-8, VEGF, and ANG in the vitreous.	cba	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
16678783-5	2006	The stimulatory effect of EGF on IL-1beta-induced IL-8 production was completely abolished by the broad range tyrosine kinase inhibitor Herbimycin A, and considerably reduced by the receptor tyrosine kinase specific inhibitor PD 153035.	herbimycin	136-148	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
16678783-6	2006	Herbimycin A abolished IL-8 production induced by IL-1beta, whereas PD 153035 had no effect on the cytokine-induced IL-8 production.	herbimycin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
16678783-7	2006	Furthermore, the p38 mitogen-activated protein (MAP) kinase inhibitor SB 203580 reduced IL-8 production induced by IL-1beta as well as by the combination of EGF and IL-1beta but had no effect on EGF-induced IL-8 production.	SB 203580	70-79	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
16963169-11	2006	However, the silica-induced up-regulation of IL-8 release through the SFK-ERK1/2 pathway does not appear to be initiated through activation of the EGFR, although basal EGFR activity may affect the magnitude of the responses.	Silicon Dioxide	13-19	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
16806458-3	2006	Results indicate that a number of the primary carbon/resin materials demonstrate efficient adsorption of the cytokines studied here (TNF, IL-6 and IL-8), comparable to other adsorbents under clinical investigation.	Carbon	46-52	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
16953188-3	2006	p38 MAPK may regulate cytokine production, therefore, the effect of two p38 MAPK inhibitors, SB239063 and SD-282, on the release of TNF-alpha, GM-CSF and IL-8 from human macrophages was investigated.	SB 239063	93-101	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
16953188-3	2006	p38 MAPK may regulate cytokine production, therefore, the effect of two p38 MAPK inhibitors, SB239063 and SD-282, on the release of TNF-alpha, GM-CSF and IL-8 from human macrophages was investigated.	indole-5-carboxamide	106-112	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
17066155-9	2006	An increased level of IL-8 during the third, fifth and seventh days of the investigation was seen in SABP patients.	sabp	101-105	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
16837501-8	2006	In conclusion, thalidomide has the potential to improve the therapeutic regimens for sarcoidosis, hypersensitivity pneumonitis and idiopathic pulmonary fibrosis by reducing tumour necrosis factor-alpha, interleukin-12p40, interleukin-18 and interleukin-8 production.	Thalidomide	15-26	C-X-C motif chemokine ligand 8	Homo sapiens	241-254
17161617-0	2006	Salbutamol inhibits trypsin-mediated production of CXCL8 by keratinocytes.	Albuterol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	51-56
17161617-2	2006	Production of CXCL8 was exquisitely sensitive to inhibition by co-treatment with the beta(2) agonist sabutamol (IC(50)=1.1 nM).	sabutamol	101-110	C-X-C motif chemokine ligand 8	Homo sapiens	14-19
17161617-4	2006	Salbutamol also elevated intracellular levels of cAMP (EC(50)=82 nM) but the relationship to the inhibition of CXCL8 secretion was not clear-cut since much higher concentrations of salbutamol were required to elevate total cellular cAMP than inhibit CXCL8 production.	Albuterol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	250-255
17161617-6	2006	Potentiation of cAMP production by co-treatment with the phosphodiesterase type 4 inhibitor rolipram only marginally enhanced the inhibitory effect of salbutamol on CXCL8 production.	Rolipram	92-100	C-X-C motif chemokine ligand 8	Homo sapiens	165-170
17161617-6	2006	Potentiation of cAMP production by co-treatment with the phosphodiesterase type 4 inhibitor rolipram only marginally enhanced the inhibitory effect of salbutamol on CXCL8 production.	Albuterol	151-161	C-X-C motif chemokine ligand 8	Homo sapiens	165-170
17161617-7	2006	Taken together, these data suggest that elevation of cAMP production is required for the inhibitory effect of salbutamol on CXCL8 production by keratinocytes and that low threshold levels of cAMP are sufficient to mediate this effect.	Cyclic AMP	53-57	C-X-C motif chemokine ligand 8	Homo sapiens	124-129
17161617-7	2006	Taken together, these data suggest that elevation of cAMP production is required for the inhibitory effect of salbutamol on CXCL8 production by keratinocytes and that low threshold levels of cAMP are sufficient to mediate this effect.	Albuterol	110-120	C-X-C motif chemokine ligand 8	Homo sapiens	124-129
17166736-5	2006	In PMA/ionomycin stimulated cells, pre-incubated with increasing concentrations of NIV, transcription was induced in the range 0.06-2 microM; higher concentrations of NIV were found non-stimulating (4 microM) or inhibitory (8 microM) for IFNgamma and IL-2 whereas IL-8 was still induced.	Ionomycin	7-16	C-X-C motif chemokine ligand 8	Homo sapiens	264-268
17166736-6	2006	DON administration elicited a similar profile for IL-8 and IFNgamma, whilst IL-2 mRNA was induced in a broader range of concentrations.	deoxynivalenol	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
17003352-7	2006	These findings implicate several factors in the insulin signaling pathway, which may be further dysregulated in HIV+IGT, and support the notion that insulin signaling pathways for glucose and leucine metabolism may be disrupted by increased proinflammatory adipocytokines (IL-8) and increased lipid oxidation.	Glucose	180-187	C-X-C motif chemokine ligand 8	Homo sapiens	273-277
16837501-0	2006	Thalidomide reduces IL-18, IL-8 and TNF-alpha release from alveolar macrophages in interstitial lung disease.	Thalidomide	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
16837501-6	2006	At the highest thalidomide concentration (0.1 mM), LPS-stimulated IL-8 production was also suppressed.	Thalidomide	15-26	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
16837501-7	2006	In IPF patients, although spontaneous production of TNF-alpha, IL-12p40, IL-18 and IL-8 was lower than in sarcoidosis and HP patients, with LPS stimulation the cytokines were significantly elevated and also partially inhibited by thalidomide.	Thalidomide	230-241	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
16715183-3	2006	In this study, we investigated the ability of homocysteine (Hcy) and homocysteine thiolactone (HcyT) to induce cell death and IL-8 secretion in primary human umbilical vein endothelial cells (HUVEC).	Homocysteine	46-58	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
16715183-3	2006	In this study, we investigated the ability of homocysteine (Hcy) and homocysteine thiolactone (HcyT) to induce cell death and IL-8 secretion in primary human umbilical vein endothelial cells (HUVEC).	Homocysteine	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
16715183-3	2006	In this study, we investigated the ability of homocysteine (Hcy) and homocysteine thiolactone (HcyT) to induce cell death and IL-8 secretion in primary human umbilical vein endothelial cells (HUVEC).	homocysteine thiolactone	69-93	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
16715183-3	2006	In this study, we investigated the ability of homocysteine (Hcy) and homocysteine thiolactone (HcyT) to induce cell death and IL-8 secretion in primary human umbilical vein endothelial cells (HUVEC).	homocysteine thiolactone	95-99	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
16545538-10	2006	The increased gene and protein expression of the pro-inflammatory cytokine IL-8, produced by endothelial cells, is likely in response to the manifestation of oxidative stress and GSH depletion; further amplifying the oxidative stress response induced by the fatty acid oxidation inhibitors and triggering an inflammatory response.	Glutathione	179-182	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
17091205-10	2006	For interleukin-8, this decrease in concentration was smaller after the dust exposures spiked with glucan and aldehydes (-2.9 and -25.8 pg/ml, respectively) than after office dust or clean air (-65.9 and -74.1 pg/ml, respectively) (P=0.042).	Glucans	99-105	C-X-C motif chemokine ligand 8	Homo sapiens	4-17
17091205-10	2006	For interleukin-8, this decrease in concentration was smaller after the dust exposures spiked with glucan and aldehydes (-2.9 and -25.8 pg/ml, respectively) than after office dust or clean air (-65.9 and -74.1 pg/ml, respectively) (P=0.042).	Aldehydes	110-119	C-X-C motif chemokine ligand 8	Homo sapiens	4-17
16545538-10	2006	The increased gene and protein expression of the pro-inflammatory cytokine IL-8, produced by endothelial cells, is likely in response to the manifestation of oxidative stress and GSH depletion; further amplifying the oxidative stress response induced by the fatty acid oxidation inhibitors and triggering an inflammatory response.	Fatty Acids	258-268	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
16581224-5	2006	Sodium nitrite at a low concentration (6.25 mM) increased IL-8 release, whereas IL-1 beta, IL-6, and TNF-alpha release increased only after exposure to high sodium nitrite concentration (25 mM).	Sodium Nitrite	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
17096697-1	2006	In the present study, we examined whether the performance of hemoperfusion with an immobilized polymyxin B fiber column (DHP-PMX) reduces circulating interleukin-8 concentration in patients with sepsis.	dhp-pmx	121-128	C-X-C motif chemokine ligand 8	Homo sapiens	150-163
16984135-10	2006	When HUVEC were treated with TNF to induce inflammatory events, pretreatment with RGDPEG-SB-HSA partially inhibited proinflammatory gene expression (IL-8, E-selectin; 30% inhibition) and secretion of cytokines (IL-8, 34% inhibition).	rgdpeg-sb-hsa	82-95	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
17096697-6	2006	Circulating interleukin-8 concentration was 55 +/- 15.7 pg/mL before DHP-PMX, while it was 101 +/- 58.8 pg/mL immediately after the first session of treatment.	dhp-pmx	69-76	C-X-C motif chemokine ligand 8	Homo sapiens	12-25
17096697-10	2006	The present findings indicate that DHP-PMX indirectly reduces circulating interleukin-8 concentration and improves SOFA score.	dhp-pmx	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
16996012-0	2006	Effect of dexamethasone on the release of transforming growth factor-beta1, interleukin-8, interleukin-10 and RANTES release by sputum cells in severe asthma.	Dexamethasone	10-23	C-X-C motif chemokine ligand 8	Homo sapiens	76-89
16857333-7	2006	The inhibition of GHB production was apparent during storage in NaF treated frozen blood samples.	4-hydroxybutyric acid	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
16632517-3	2006	Blocking of gene transcription with actinomycin D suggested that NE stimulated IL-8 synthesis via increased mRNA expression, which was verified by real-time RT-PCR.	Dactinomycin	36-49	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
16632517-5	2006	The results from the use of chemical inhibitors and mutant gene constructs against various signal transduction components seem to suggest the linear signaling pathway involving the activation of PKC-delta --&gt; dual oxidase 1 --&gt; reactive oxygen species --&gt; TNF-alpha-converting enzyme --&gt; EGF receptor --&gt; p38 --&gt; NF-kappaB for NE-activated IL-8 gene expression.	Reactive Oxygen Species	234-257	C-X-C motif chemokine ligand 8	Homo sapiens	358-362
16842752-7	2006	Moreover, we found that SM-7409 strongly inhibits the LPS-induced other pro-inflammatory cytokines, such as interleukin (IL)-1beta and IL-8 in PBMCs.	SM 7409	24-31	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
17000667-0	2006	Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
17000667-10	2006	Moreover, curcumin blocked neurotensin-stimulated IL-8 gene induction and protein secretion and, at a low concentration (i.e., 10 micromol/L), blocked neurotensin-stimulated colon cancer cell migration.	Curcumin	10-18	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
16870149-4	2006	Treatment of HeLa cells with apicidin leads to an increase in transcriptional activity of NF-kappaB and the expression of its target genes, IL-8 and TNF-alpha.	apicidin	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
16581825-0	2006	Differential regulation of hyaluronan-induced IL-8 and IP-10 in airway epithelial cells.	Hyaluronic Acid	27-37	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
16581825-5	2006	Furthermore, hyaluronan fragments use two distinct molecular pathways to induce IL-8 and IFN-gamma-inducible protein 10 (IP-10) chemokine expression in airway epithelial cells.	Hyaluronic Acid	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
16581825-6	2006	Hyaluronan-induced IL-8 requires the MAP kinase pathway, whereas hyaluronan-induced IP-10 utilizes the NF-kappaB pathway.	Hyaluronic Acid	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
16581825-9	2006	Furthermore, hyaluronan, by inducing IL-8 and IP-10 by distinct pathways, provides a unique target for differential regulation of key inflammatory chemokines.	Hyaluronic Acid	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
16741151-0	2006	Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome.	Azithromycin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	45-58
16741151-4	2006	HYPOTHESES: (1) Azithromycin reduces airway neutrophilia and interleukin (IL)-8 and (2) airway neutrophilia predicts the improvement in FEV(1).	Azithromycin	16-28	C-X-C motif chemokine ligand 8	Homo sapiens	61-79
16741151-11	2006	CONCLUSION: Azithromycin significantly reduces airway neutrophilia and IL-8 mRNA in patients with BOS.	Azithromycin	12-24	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
16741151-11	2006	CONCLUSION: Azithromycin significantly reduces airway neutrophilia and IL-8 mRNA in patients with BOS.	N-[4-(Aminosulfonyl)phenyl]-2-Mercaptobenzamide	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
16984135-10	2006	When HUVEC were treated with TNF to induce inflammatory events, pretreatment with RGDPEG-SB-HSA partially inhibited proinflammatory gene expression (IL-8, E-selectin; 30% inhibition) and secretion of cytokines (IL-8, 34% inhibition).	rgdpeg-sb-hsa	82-95	C-X-C motif chemokine ligand 8	Homo sapiens	211-215
16936090-6	2006	Triptolide and dexamethasone each inhibited in a concentration-dependent manner the LPS-induced release of IL-6, G-CSF, MCP-1, and IL-8 by corneal fibroblasts.	Dexamethasone	15-28	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
16951177-8	2006	In addition, Src inhibition alone and in combination with docetaxel significantly down-regulated tumoral production of vascular endothelial growth factor and interleukin 8, whereas combination therapy decreased the microvessel density (P = 0.02) and significantly affected vascular permeability (P &lt; 0.05).	Docetaxel	58-67	C-X-C motif chemokine ligand 8	Homo sapiens	158-171
17699316-9	2006	Serum IL-8 and TNF-alpha concentrations were significantly reduced by aspirin treatment at 4 mo (P = 0.04 and P = 0.007, respectively).	Aspirin	70-77	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
16534530-13	2006	DISCUSSION: Our data demonstrated that the circulating levels of MCP-1 and IL-8 are related to obesity-related parameters such as BMI, waist circumference, CRP, IL-6, HOMA and HDL-cholesterol.	Cholesterol	180-191	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
16936090-6	2006	Triptolide and dexamethasone each inhibited in a concentration-dependent manner the LPS-induced release of IL-6, G-CSF, MCP-1, and IL-8 by corneal fibroblasts.	triptolide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
16624828-0	2006	1alpha, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis.	Calcitriol	0-30	C-X-C motif chemokine ligand 8	Homo sapiens	42-55
16807115-6	2006	IL-8 production from LPMC was significantly reduced by GC addition in responsive cases but not in refractory cases.	lpmc	21-25	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
16807115-8	2006	In addition, p38-MAPK antagonist SB230580 also ameliorated GC-resistant IL-8 production.	sb230580	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
16936090-10	2006	CONCLUSIONS: Triptolide inhibits the LPS-induced expression of IL-6, chemokines (G-CSF, MCP-1, IL-8), and ICAM-1 in cultured human corneal fibroblasts.	triptolide	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
16775254-8	2006	We also show that cell-permeant C6 ceramide, like OxPAPC, causes the inhibition of LPS-induced IL-8 synthesis and alters caveolin distribution similar to OxPAPC.	Ceramides	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
16920938-6	2006	In addition, As2O3 reduced expression of various macrophagic surface markers, enhanced that of the monocytic marker CD14, and altered both endocytosis and phagocytosis; unexpectedly, exposure of macrophages to the metalloid also strongly potentiated expression of TNFalpha and IL-8 induced by LPS.	Arsenic Trioxide	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	277-281
17111070-10	2006	In an assay for inhibition of the H(2)O(2)-activated release of PGE2, IL-6, and IL-8 in normal human fibroblast cell lines, Ulmus davidiana root extract showed an inhibitory activity of PGE2 release in a dose-dependent manner (up to 85.9% at a concentration of 0.1%).	Hydrogen Peroxide	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
17111070-10	2006	In an assay for inhibition of the H(2)O(2)-activated release of PGE2, IL-6, and IL-8 in normal human fibroblast cell lines, Ulmus davidiana root extract showed an inhibitory activity of PGE2 release in a dose-dependent manner (up to 85.9% at a concentration of 0.1%).	Dinoprostone	186-190	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
16775254-1	2006	Previous studies from our laboratory and others presented evidence that oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylcholine (OxPAPC) and oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylethanolamine can inhibit lipopolysaccharide (LPS)-mediated induction of interleukin-8 (IL-8) in endothelial cells.	1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylcholine	81-139	C-X-C motif chemokine ligand 8	Homo sapiens	285-298
16775254-1	2006	Previous studies from our laboratory and others presented evidence that oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylcholine (OxPAPC) and oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylethanolamine can inhibit lipopolysaccharide (LPS)-mediated induction of interleukin-8 (IL-8) in endothelial cells.	1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylcholine	81-139	C-X-C motif chemokine ligand 8	Homo sapiens	300-304
16984733-7	2006	Following indomethacin treatment in breast cancer cells, several candidate genes, such as interleukin 8, NGFB, CSF2, RHOB, EDN1, and JUNB, were differentially expressed, which may have contributed to changes in choline metabolism through secondary effects or signaling cascades leading to changes in enzyme activity.	Indomethacin	10-22	C-X-C motif chemokine ligand 8	Homo sapiens	90-103
16775254-1	2006	Previous studies from our laboratory and others presented evidence that oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylcholine (OxPAPC) and oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylethanolamine can inhibit lipopolysaccharide (LPS)-mediated induction of interleukin-8 (IL-8) in endothelial cells.	oxpapc	141-147	C-X-C motif chemokine ligand 8	Homo sapiens	285-298
16775254-1	2006	Previous studies from our laboratory and others presented evidence that oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylcholine (OxPAPC) and oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylethanolamine can inhibit lipopolysaccharide (LPS)-mediated induction of interleukin-8 (IL-8) in endothelial cells.	oxpapc	141-147	C-X-C motif chemokine ligand 8	Homo sapiens	300-304
16775254-1	2006	Previous studies from our laboratory and others presented evidence that oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylcholine (OxPAPC) and oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylethanolamine can inhibit lipopolysaccharide (LPS)-mediated induction of interleukin-8 (IL-8) in endothelial cells.	1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylethanolamine	162-225	C-X-C motif chemokine ligand 8	Homo sapiens	285-298
16775254-1	2006	Previous studies from our laboratory and others presented evidence that oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylcholine (OxPAPC) and oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylethanolamine can inhibit lipopolysaccharide (LPS)-mediated induction of interleukin-8 (IL-8) in endothelial cells.	1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylethanolamine	162-225	C-X-C motif chemokine ligand 8	Homo sapiens	300-304
17072061-4	2006	In this study we evaluated the influence of N-acetylcysteine (NAC) (0.01 mM-30 mM) on the cytokine-induced (TNF-alpha/IL-1 beta) expression of the ICAM-1 adhesion molecule and on IL-8 release in endothelial (ECV-304) and bronchial epithelial (H292) cell lines.	Acetylcysteine	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
17072061-6	2006	NAC inhibited the TNF-alpha/IL-1 beta-stimulated ICAM-1 expression and IL-8 release from both cell lines in a concentration dependent manner.	Acetylcysteine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
17072061-8	2006	We conclude that NAC is an effective inhibitor of TNF-alpha/IL-1 beta- stimulated ICAM-1 and IL-8 release in endothelial and epithelial cells.	Acetylcysteine	17-20	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
16984733-7	2006	Following indomethacin treatment in breast cancer cells, several candidate genes, such as interleukin 8, NGFB, CSF2, RHOB, EDN1, and JUNB, were differentially expressed, which may have contributed to changes in choline metabolism through secondary effects or signaling cascades leading to changes in enzyme activity.	Choline	211-218	C-X-C motif chemokine ligand 8	Homo sapiens	90-103
16621025-0	2006	Induction of interleukin-8 expression in porcine peripheral blood mononuclear cells by trans10-cis12 conjugated linoleic acid.	Linoleic Acid	112-125	C-X-C motif chemokine ligand 8	Homo sapiens	13-26
16448811-0	2006	Inhibition of pyocyanin-potentiated IL-8 release by steroids in bronchial epithelial cells.	Pyocyanine	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
16448811-0	2006	Inhibition of pyocyanin-potentiated IL-8 release by steroids in bronchial epithelial cells.	Steroids	52-60	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
16448811-2	2006	Pyocyanin-induced synergism with interleukin (IL)-1 or tumour necrosis factor (TNF) in triggering IL-8 release has been documented previously.	Pyocyanine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
16448811-3	2006	In this study, IL-8 mRNA and protein expression were examined in cultured human bronchial epithelial cells (BEAS-2B) stimulated with pyocyanin alone, and in combination with IL-1beta or phorbol 12,13-dibutyrate (PDBu) in the absence and presence of a group of glucocorticoids.	Pyocyanine	133-142	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
16448811-6	2006	However, pyocyanin upregulated the stimulatory effect of IL-1beta or PDBu on the release of IL-8 in a dose-dependent manner.	Pyocyanine	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
16448811-7	2006	The stimulatory effect of pyocyanin on the IL-1beta- or PDBu-stimulated IL-8 release was reduced in the presence of dexamethasone, budesonide, and fluticasone.	Pyocyanine	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
16448811-7	2006	The stimulatory effect of pyocyanin on the IL-1beta- or PDBu-stimulated IL-8 release was reduced in the presence of dexamethasone, budesonide, and fluticasone.	Dexamethasone	116-129	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
16448811-7	2006	The stimulatory effect of pyocyanin on the IL-1beta- or PDBu-stimulated IL-8 release was reduced in the presence of dexamethasone, budesonide, and fluticasone.	Budesonide	131-141	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
16448811-7	2006	The stimulatory effect of pyocyanin on the IL-1beta- or PDBu-stimulated IL-8 release was reduced in the presence of dexamethasone, budesonide, and fluticasone.	Fluticasone	147-158	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
16448811-9	2006	The protein kinase C (PKC) inhibitor, Go6976, also significantly reduced the stimulatory effect of pyocyanin on IL-1beta, and PDBu increased IL-8 release.	Go 6976	38-44	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
16448811-10	2006	In conclusion, this study shows that PKC signal pathway seems to be involved in the pyocyanin-mediated upregulation of the IL-1beta and PDBu-induced IL-8 release in BEAS-2B cells.	Pyocyanine	84-93	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
16469490-9	2006	Blocking rho kinase using Y-27632 inhibited the effect of stretch on IL-8 release by the BEAS 2B cells.	Y 27632	26-33	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
16937534-2	2006	METHODS: IL-8 -251 A/T polymorphism was genotyped by oligonucleotide allele specific PCR (ASO-PCR) in a sample of 233 patients with H pylori infection undergoing upper gastrointestinal endoscopy.	Oligonucleotides	53-68	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
16912112-1	2006	Oxidized phospholipids are thought to promote atherogenesis by stimulating endothelial cells (ECs) to produce inflammatory cytokines, such as IL-8.	Phospholipids	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
16937467-10	2006	Although all three MAP kinase family members were phosphorylated in response to TNF-alpha, a selective inhibitor of p38 kinase SB203580 only could inhibit both NF-kappaB-dependent transcriptional activity and IL-8 and CCL20 production, suggesting a potential link between p38 kinase and NF-kappaB-dependent pathways in AGS cells.	SB 203580	127-135	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
17075545-2	2006	In vitro studies have demonstrated the anti-inflammatory effects of macrolides: decreased productions of IL-6, IL-8, TNF alpha, chemotactism of polymorphonuclear neutrophils.	Macrolides	68-78	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
16948846-5	2006	Two of these four compounds, alpha-mangostin and 18-beta-glycyrrhetinic acid, activated NFkappaB and induced IL-8 secretion.	mangostin	29-44	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
16948846-5	2006	Two of these four compounds, alpha-mangostin and 18-beta-glycyrrhetinic acid, activated NFkappaB and induced IL-8 secretion.	18alpha-glycyrrhetinic acid	49-76	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
16621025-6	2006	This study strongly suggests that the immunoenhancing effect of CLA on the chemotactic response of porcine PMN is mediated through IL-8 produced by CLA treated PBMC.	Linoleic Acids, Conjugated	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
16239062-2	2006	RA also reduced intracellular reactive oxygen species (ROS) level, H2O2-dependent VEGF expression and IL-8 release of endothelial cells.	rosmarinic acid	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
16239062-3	2006	These findings suggested that the anti-angiogenic potential of RA might be related to its anti-oxidative activity, which further resulted in the inhibition of ROS-associated VEGF expression and IL-8 release.	rosmarinic acid	63-65	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
16621025-6	2006	This study strongly suggests that the immunoenhancing effect of CLA on the chemotactic response of porcine PMN is mediated through IL-8 produced by CLA treated PBMC.	Linoleic Acids, Conjugated	148-151	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
16697193-1	2006	A novel series of 3,4-diaminocyclobut-3-ene-1,2-diones was prepared and found to show potent inhibitory activity of CXCR2 binding and IL-8-mediated chemotaxis of a CXCR2-expressing cell line.	3,4-diaminocyclobut-3-ene-1,2-dione	18-54	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
16485121-5	2006	The lowest HEK mortality (7%) and the highest IL-8 production were induced with mixtures including high cytotoxic and weak IL-8 inductive ARO hydrocarbons.	Hydrocarbons, Aromatic	138-154	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
16485121-5	2006	The lowest HEK mortality (7%) and the highest IL-8 production were induced with mixtures including high cytotoxic and weak IL-8 inductive ARO hydrocarbons.	Hydrocarbons, Aromatic	138-154	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
16485121-7	2006	Single addition of benzene, toluene, xylene or ethylbenzene for up to tenfold in JP-8 did not increase HEK mortality while single addition of ALI hydrocarbons exhibited dose-related differential response in IL-8.	ali hydrocarbons	142-158	C-X-C motif chemokine ligand 8	Homo sapiens	207-211
16485121-8	2006	In an all ALI environment, no single hydrocarbon is the dominating factor in the determination of HEK cytotoxicity while deletion of hexadecane resulted in a 2.5-fold increase in IL-8 production.	n-hexadecane	133-143	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
16861626-5	2006	Eight months following treatment with a single dose of ivermectin-albendazole, some of these defects were reversed, with monocyte production of IL-8, IL-1alpha, MIP-1alpha, and IL-10 being comparable to that seen in the uninfected controls.	ivermectin-albendazole	55-77	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
16798838-4	2006	The tyrosine kinase inhibitor Tyrphostin A9, phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002 as well as proteasome inhibitors significantly blocked the CXCL8-induced chemotaxis of L1.2 cells and human neutrophils.	tyrphostin A9	30-43	C-X-C motif chemokine ligand 8	Homo sapiens	160-165
16798838-4	2006	The tyrosine kinase inhibitor Tyrphostin A9, phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002 as well as proteasome inhibitors significantly blocked the CXCL8-induced chemotaxis of L1.2 cells and human neutrophils.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	C-X-C motif chemokine ligand 8	Homo sapiens	160-165
16798838-9	2006	The CXCL8-induced phosphorylation of Cbl was also reduced when cells were pre-treated with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	C-X-C motif chemokine ligand 8	Homo sapiens	4-9
16798838-10	2006	Lastly, we have shown that pre-treatment of L1.2 cells with the proteasome inhibitor Lactacystin blocks CXCL8-induced internalization of the CXCR1 and CXCR2 receptors.	lactacystin	85-96	C-X-C motif chemokine ligand 8	Homo sapiens	104-109
16911361-7	2006	RESULTS: Real-time PCR revealed that poly I : C significantly increased the expression of mRNAs for chemokines IP-10, RANTES, LARC, MIP-1alpha, IL-8, GRO-alpha and ENA-78 and cytokines IL-1beta, GM-CSF, IL-6 and the cell adhesion molecule ICAM-1 in both cell types.	Poly I	37-43	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
16907497-1	2006	We report the first observation of anti-Stokes laser-induced cooling in the Er3+:KPb2Cl5 crystal and in the Er3+:CNBZn (CdF2-CdCl2-NaF-BaF2-BaCl2-ZnF2) glass.	cnbzn	113-118	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
16491109-8	2006	RESULTS: Subjects receiving folic acid supplementation showed a decrement of homocysteine and an amelioration of insulin sensitivity; this treatment was also associated with a significant drop in the circulating concentration of monocyte chemoattractant protein-1, interleukin-8 and C-reactive protein, in the absence of any significant variation of BMI or fat mass.	Folic Acid	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	265-278
16884979-14	2006	CONCLUSION: Sevoflurane suppressed the production of IL-6 and IL-8, but not IL-10 and IL-1ra.	Sevoflurane	12-23	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
16769764-0	2006	IL-6 and IL-8 release is mediated via multiple signaling pathways after stimulating dendritic cells with lysophospholipids.	Lysophospholipids	105-122	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
16797033-0	2006	Effect of berberrubine on interleukin-8 and monocyte chemotactic protein-1 expression in human retinal pigment epithelial cell line.	berberrubine	10-22	C-X-C motif chemokine ligand 8	Homo sapiens	26-39
16797033-1	2006	We examined the effects of berberrubine, a protoberberine alkaloid, on interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) expression in a human retinal pigment epithelial cell line (ARPE-19) stimulated with interleukin-1beta (IL-1beta) or tumor necrosis factor alpha (TNF-alpha).	berberrubine	27-39	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
16797033-7	2006	Berberrubine dose-dependently inhibited IL-8 and MCP-1 protein levels in the media and mRNA expression of the cells stimulated with IL-1beta or TNF-alpha.	berberrubine	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
16797033-10	2006	Berberrubine dose-dependently inhibited IL-8 and MCP-1 expression and protein secretion induced by IL-1beta or TNF-alpha.	berberrubine	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
16842506-8	2006	In addition, IL-8 (or an analogue) was found in the candidal mother cell in chronic hyperplastic candidosis and in agar, whereas the tips of the hyphae expressed IL-8 receptor A (or an analogue).	Agar	115-119	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
16687414-0	2006	Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cdelta, Lyn kinase, and matrix metalloproteinases.	lysophosphatidic acid	14-35	C-X-C motif chemokine ligand 8	Homo sapiens	97-110
16614347-6	2006	LPS-induced release of 10 cytokines was less suppressed by dexamethasone (10(-6) M) in patients with severe asthma compared with patients with nonsevere asthma, with statistical significance achieved for IL-1beta (p &lt; 0.03), IL-8 (p &lt; 0.03), and MIP-1alpha (p &lt; 0.003), and borderline significance for IL-6 (p = 0.054).	Dexamethasone	59-72	C-X-C motif chemokine ligand 8	Homo sapiens	228-232
16834783-14	2006	Like dexamethasone and mometasone, RU24858 did suppress IL-8 and MCP-1 production in eosinophils.	RU24858	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
16834785-7	2006	Inhibition of JNK by small molecule inhibitor SP600125 reduced pneumococci-induced IL-8 mRNA expression and release of IL-8 and IL-6.	pyrazolanthrone	46-54	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
16834785-7	2006	Inhibition of JNK by small molecule inhibitor SP600125 reduced pneumococci-induced IL-8 mRNA expression and release of IL-8 and IL-6.	pyrazolanthrone	46-54	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
16801185-12	2006	Serum interleukin -8 may be useful in assessing the therapeutic effects of cyclosporine A in hyperzincaemia and hypercalprotectinaemia.	Cyclosporine	75-89	C-X-C motif chemokine ligand 8	Homo sapiens	6-20
16687414-7	2006	Furthermore, down-regulation of EGFR by EGFR small interfering RNA or pretreatment of cells with EGFR inhibitors AG1478 and PD158780 almost completely blocked LPA-dependent EGFR phosphorylation and partially attenuated IL-8 secretion, respectively.	RTKI cpd	113-119	C-X-C motif chemokine ligand 8	Homo sapiens	219-223
16687414-7	2006	Furthermore, down-regulation of EGFR by EGFR small interfering RNA or pretreatment of cells with EGFR inhibitors AG1478 and PD158780 almost completely blocked LPA-dependent EGFR phosphorylation and partially attenuated IL-8 secretion, respectively.	6-(methylamino)pyrido(3,4-d)pyrimidine	124-132	C-X-C motif chemokine ligand 8	Homo sapiens	219-223
16687414-8	2006	These results demonstrate that LPA-induced IL-8 secretion is partly dependent on EGFR transactivation regulated by PKCdelta-dependent activation of Lyn kinase and MMPs and proHB-EGF shedding, suggesting a novel mechanism of cross-talk and interaction between G-protein-coupled receptors and receptor-tyrosine kinases in HBEpCs.	lysophosphatidic acid	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
16687414-1	2006	We have demonstrated earlier that lysophosphatidic acid (LPA)-induced interleukin-8 (IL-8) secretion is regulated by protein kinase Cdelta (PKCdelta)-dependent NF-kappaB activation in human bronchial epithelial cells (HBEpCs).	lysophosphatidic acid	34-55	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
16687414-1	2006	We have demonstrated earlier that lysophosphatidic acid (LPA)-induced interleukin-8 (IL-8) secretion is regulated by protein kinase Cdelta (PKCdelta)-dependent NF-kappaB activation in human bronchial epithelial cells (HBEpCs).	lysophosphatidic acid	34-55	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
16687414-1	2006	We have demonstrated earlier that lysophosphatidic acid (LPA)-induced interleukin-8 (IL-8) secretion is regulated by protein kinase Cdelta (PKCdelta)-dependent NF-kappaB activation in human bronchial epithelial cells (HBEpCs).	lysophosphatidic acid	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
16687414-1	2006	We have demonstrated earlier that lysophosphatidic acid (LPA)-induced interleukin-8 (IL-8) secretion is regulated by protein kinase Cdelta (PKCdelta)-dependent NF-kappaB activation in human bronchial epithelial cells (HBEpCs).	lysophosphatidic acid	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
16473865-3	2006	The aim of this study was to investigate the molecular mechanism(s) of inflammatory responses caused by cigarette smoke extract (CSE) in the human macrophage-like cell line MonoMac6 and whether the treatment of these cells with the antioxidant glutathione (GSH) monoethyl ester, or modulation of the thioredoxin redox system, can attenuate cigarette smoke-mediated IL-8 release.	Glutathione	244-255	C-X-C motif chemokine ligand 8	Homo sapiens	365-369
16473865-8	2006	Pretreatment of cells with GSH monoethyl ester, but not thioredoxin/thioredoxin reductase, reversed cigarette smoke-induced reduction in HDAC levels and significantly inhibited IL-8 release.	gsh monoethyl ester	27-46	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
16687414-2	2006	Here we provide evidence for signaling pathways that regulate LPA-mediated transactivation of epidermal growth factor receptor (EGFR) and the role of cross-talk between G-protein-coupled receptors and receptor-tyrosine kinases in IL-8 secretion in HBEpCs.	lysophosphatidic acid	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	230-234
16522819-4	2006	Adenosine compounds also desensitized IL-8- and MCP-1-induced chemotaxis, but not that induced by fMLP.	Adenosine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	38-43
16945263-6	2006	IL-8, leukotriene B4, and 8-isoprostano in EBC correlated significantly with DLCO/VA (% of predicted) (r = 0.30, P &lt; .05; r = 0.29, P &lt; or = .05; and r = 0.46, P &lt; .01, respectively) but not with forced expiratory volume in 1 second.	NSC638702	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
16945263-7	2006	There was a negative correlation between EBC and serum levels of both IL-8 (r = -0.31; P &lt; .05) and 8-isoprostane (r = -0.51; P &lt; .001).	NSC638702	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
16819191-7	2006	Furthermore, curcumin significantly attenuated Stx-1 induced cell death and IL-8 expression.	Curcumin	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
16956428-7	2006	Hcy enhanced IL-6 and IL-8 production in RA synoviocytes only (up to 35%).	Homocysteine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
16283305-4	2006	TMV also carried mRNA for growth factors: vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), interleukin-8 (IL-8) and surface determinants (CD44H).	tmv	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	117-130
16283305-4	2006	TMV also carried mRNA for growth factors: vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), interleukin-8 (IL-8) and surface determinants (CD44H).	tmv	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
16723241-1	2006	OBJECTIVE: Lactate levels after cardiac surgery are influenced by different proinflammatory (TNF, IL-6, IL-8) and anti-inflammatory (IL-10) cytokines.	Lactic Acid	11-18	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
17077666-7	2006	In contrast, Dex treatment inhibited the IL-1beta-induced production of GM-CSF, IL-6, IL-8, MCP-3, and RANTES, but not MCP-1.	Dexamethasone	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
16949835-0	2006	Roles of p38 and ERK MAP kinases in IL-8 expression in TNF-alpha- and dexamethasone-stimulated human periodontal ligament cells.	Dexamethasone	70-83	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
16949835-3	2006	In this study, we investigated the role of mitogen-activated protein (MAP) kinases in dexamethasone- and TNF-alpha-induced IL-8 and ICAM-1 expression in hPDL cells.	Dexamethasone	86-99	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
16949835-7	2006	Dexamethasone suppressed TNF-alpha-induced IL-8 production in a dose-dependent manner.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
16949835-10	2006	Furthermore, these results suggest that inflammatory cytokine- and dexamethasone-induced IL-8 and ICAM-1, produced via a MAP kinase pathway, may serve as an important mediator of PDL immunoregulation involved in bone remodeling during orthodontic tooth movement.	Dexamethasone	67-80	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
16761312-5	2006	sPLA(2) induced the phosphorylation of the MAPK p38 and ERK1/2, and inhibition of these kinases by SB203580 and PD98059, respectively, reduced TNF-alpha and CXCL8 release.	SB 203580	99-107	C-X-C motif chemokine ligand 8	Homo sapiens	157-162
16714014-0	2006	Cannabinoid signalling in TNF-alpha induced IL-8 release.	Cannabinoids	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
16723156-0	2006	High dose of intravenously given glucocorticosteroids decrease IL-8 production by monocytes in multiple sclerosis patients treated during relapse.	glucocorticosteroids	33-53	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
16761312-5	2006	sPLA(2) induced the phosphorylation of the MAPK p38 and ERK1/2, and inhibition of these kinases by SB203580 and PD98059, respectively, reduced TNF-alpha and CXCL8 release.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	112-119	C-X-C motif chemokine ligand 8	Homo sapiens	157-162
16761312-7	2006	GIA activated the phosphatidylinositol 3-kinase (PI3 K)/Akt system and a specific inhibitor of PI3 K (LY294002) reduced sPLA(2)-induced release of TNF-alpha and CXCL8.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	C-X-C motif chemokine ligand 8	Homo sapiens	161-166
16761312-8	2006	GIA promoted phosphorylation and degradation of IkappaB and inhibition of NF-kappaB by MG-132 and 6-amino-4-phenoxyphenylethylamino-quinazoline suppressed the production of TNF-alpha and CXCL8.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	87-93	C-X-C motif chemokine ligand 8	Homo sapiens	187-192
16761312-8	2006	GIA promoted phosphorylation and degradation of IkappaB and inhibition of NF-kappaB by MG-132 and 6-amino-4-phenoxyphenylethylamino-quinazoline suppressed the production of TNF-alpha and CXCL8.	6-amino-4-phenoxyphenylethylamino-quinazoline	98-143	C-X-C motif chemokine ligand 8	Homo sapiens	187-192
16804397-6	2006	Muramyl dipeptide-induced enhancement of interleukin (IL)-8 secretion and synergistic increase in lipopolysaccharide-induced IL-1beta secretion were studied.	Acetylmuramyl-Alanyl-Isoglutamine	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	41-59
16804397-8	2006	RESULTS: The assay was highly sensitive and specific for detection of profound defects in muramyl dipeptide sensing caused by double NOD2 mutations (IL-8 P = 0.0002; IL-1beta P = 0.0002).	Dipeptides	98-107	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
16804397-10	2006	Healthy NOD2 heterozygotes had modest impairment of muramyl dipeptide induced IL-8 secretion (P = 0.003).	muramyl	52-59	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
16804397-10	2006	Healthy NOD2 heterozygotes had modest impairment of muramyl dipeptide induced IL-8 secretion (P = 0.003).	Dipeptides	60-69	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
16804400-8	2006	Interestingly, gliotoxin induced HO-1 in HT-29 cells and, in turn, inhibition of HO-1 activity by a zinc protoporphyrin IX reversed the effects of gliotoxin in terms of I-kappaB degradation, intercellular adhesion molecule-1 expression, and IL-8 production.	Gliotoxin	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	241-245
16804400-8	2006	Interestingly, gliotoxin induced HO-1 in HT-29 cells and, in turn, inhibition of HO-1 activity by a zinc protoporphyrin IX reversed the effects of gliotoxin in terms of I-kappaB degradation, intercellular adhesion molecule-1 expression, and IL-8 production.	zinc protoporphyrin	100-122	C-X-C motif chemokine ligand 8	Homo sapiens	241-245
16804400-8	2006	Interestingly, gliotoxin induced HO-1 in HT-29 cells and, in turn, inhibition of HO-1 activity by a zinc protoporphyrin IX reversed the effects of gliotoxin in terms of I-kappaB degradation, intercellular adhesion molecule-1 expression, and IL-8 production.	Gliotoxin	147-156	C-X-C motif chemokine ligand 8	Homo sapiens	241-245
16723156-4	2006	IL-8 is one of the cytokines responsible for blood-brain-barrier disruption and migration of immune cells to the central nervous system; in this aspect, explaining glucocorticosteroid effects during MS exacerbations.	glucocorticosteroid	164-183	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
16621797-7	2006	Inhibition of the proteasome with bortezomib (PS-341/Velcade) also rescued CFTR, but with less efficiency, and suppressed NFkappaB-mediated IL8 activation.	Bortezomib	34-44	C-X-C motif chemokine ligand 8	Homo sapiens	140-143
17013434-5	2006	It has been demonstrated that thalidomide inhibits TNFalpha, IL-5, IL-6, IL-8, IL-12 production and increases production of IL-2, IL-10 and INFgamma.	Thalidomide	30-41	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
16611624-0	2006	c-Src is the primary signaling mediator of polychlorinated biphenyl-induced interleukin-8 expression in a human microvascular endothelial cell line.	Polychlorinated Biphenyls	43-67	C-X-C motif chemokine ligand 8	Homo sapiens	76-89
16611624-2	2006	Therefore, the present study focused on the regulatory mechanisms of IL-8 expression induced by environmental pollutants such as polychlorinated biphenyls (PCBs).	Polychlorinated Biphenyls	129-154	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
16611624-2	2006	Therefore, the present study focused on the regulatory mechanisms of IL-8 expression induced by environmental pollutants such as polychlorinated biphenyls (PCBs).	Polychlorinated Biphenyls	156-160	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
16611624-3	2006	Treatment of human microvascular endothelial cells (HMECs) with specific PCB congener, 2,2",4,6,6"-pentachlorobiphenyl (PCB 104), dose dependently increased levels of IL-8 mRNA and secreted protein.	2,2',4,6,6'-pentachlorobiphenyl	87-118	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
16678856-13	2006	Treatment with the COX-2 inhibitor NS-398 at a low 1-mu[scap]M dose reduced the production of IL-8 in COX-2-transfected MDA-231 cells by 30%, thus confirming the involvement of COX-2 in IL-8 induction.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	35-41	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
16678856-13	2006	Treatment with the COX-2 inhibitor NS-398 at a low 1-mu[scap]M dose reduced the production of IL-8 in COX-2-transfected MDA-231 cells by 30%, thus confirming the involvement of COX-2 in IL-8 induction.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	35-41	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
16784240-0	2006	Probing receptor binding activity of interleukin-8 dimer using a disulfide trap.	Disulfides	65-74	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
16621797-8	2006	The inhibition of the major stress-inducible transcription factor CHOP (CCAAT/enhancer-binding protein homologous protein)/GADD153 together with bortezomib was most effective in repressing NFkappaB-mediated IL8 activation compared with interference of VCP, MLN-273 (proteasome inhibitor), or 4-phenylbutyrate (histone deacetylase inhibitor).	gadd153	123-130	C-X-C motif chemokine ligand 8	Homo sapiens	207-210
16800483-0	2006	Formation of porous carbon materials with in situ generated NaF nanotemplate.	Carbon	20-26	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
16800483-1	2006	Porous carbon materials with pore sizes from 3 to 200 nm were synthesized by reacting hexafluorobenzene with Na liquid at 623 K. NaF crystals, a byproduct formed in the reaction, acted as nanotemplate to assist the pore formation.	Carbon	7-13	C-X-C motif chemokine ligand 8	Homo sapiens	129-132
16800483-1	2006	Porous carbon materials with pore sizes from 3 to 200 nm were synthesized by reacting hexafluorobenzene with Na liquid at 623 K. NaF crystals, a byproduct formed in the reaction, acted as nanotemplate to assist the pore formation.	hexafluorobenzene	86-103	C-X-C motif chemokine ligand 8	Homo sapiens	129-132
16621797-8	2006	The inhibition of the major stress-inducible transcription factor CHOP (CCAAT/enhancer-binding protein homologous protein)/GADD153 together with bortezomib was most effective in repressing NFkappaB-mediated IL8 activation compared with interference of VCP, MLN-273 (proteasome inhibitor), or 4-phenylbutyrate (histone deacetylase inhibitor).	Bortezomib	145-155	C-X-C motif chemokine ligand 8	Homo sapiens	207-210
16621797-8	2006	The inhibition of the major stress-inducible transcription factor CHOP (CCAAT/enhancer-binding protein homologous protein)/GADD153 together with bortezomib was most effective in repressing NFkappaB-mediated IL8 activation compared with interference of VCP, MLN-273 (proteasome inhibitor), or 4-phenylbutyrate (histone deacetylase inhibitor).	N-(4-morpholine)carbonyl-beta-(1-naphthyl)-alanyl-leucine boronic acid	257-264	C-X-C motif chemokine ligand 8	Homo sapiens	207-210
16621797-8	2006	The inhibition of the major stress-inducible transcription factor CHOP (CCAAT/enhancer-binding protein homologous protein)/GADD153 together with bortezomib was most effective in repressing NFkappaB-mediated IL8 activation compared with interference of VCP, MLN-273 (proteasome inhibitor), or 4-phenylbutyrate (histone deacetylase inhibitor).	4-phenylbutyric acid	292-308	C-X-C motif chemokine ligand 8	Homo sapiens	207-210
16650380-0	2006	Effect of herbal melanin on IL-8: a possible role of Toll-like receptor 4 (TLR4).	Melanins	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
16650380-2	2006	In this study, we tested the effect of a herbal melanin (HM) extract, from black cumin seeds (Nigella sativa L.), on IL-8 production.	Melanins	48-55	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
16650380-3	2006	We used HM and LPS in parallel to induce IL-8 production by THP-I, PBMCs, and TLR4-transfected HEK293 cells.	His-Met	8-10	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
16650380-5	2006	On applying similar treatment to HEK293 cells that express TLR4, MD2, and CD14, both HM and LPS significantly induced IL-8 protein production.	His-Met	85-87	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
16650380-6	2006	We have also demonstrated that HM and LPS had identical effects in terms of IL-8 stimulation by HEK293 transfected with either TLR4 or MD2-CD14.	His-Met	31-33	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
16650380-7	2006	Melanin extracted from N. sativa L. mimics the action of LPS in the induction of IL-8 by PBMC and the other used cell lines.	Melanins	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
16541418-8	2006	TGF-beta1 stimulated IL-8 expression in dose- and time-dependent manners, which was blocked by cycloheximide (CHX) and actinomycin D (ActD).	Cycloheximide	95-108	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
16364386-10	2006	Taken together, these data suggest that (1) p38 activation was required for induction of IL-8 and proinflammatory gene expression in the monocyte and (2) DON induced p38 activation in human monocytes via the ribotoxic stress response.	deoxynivalenol	154-157	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
16364386-0	2006	p38 Mitogen-activated protein kinase mediates IL-8 induction by the ribotoxin deoxynivalenol in human monocytes.	ribotoxin	68-77	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
16364386-0	2006	p38 Mitogen-activated protein kinase mediates IL-8 induction by the ribotoxin deoxynivalenol in human monocytes.	deoxynivalenol	78-92	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
16364386-1	2006	The effects of the ribotoxic trichothecene deoxynivalenol (DON) on mitogen-activated protein kinase (MAPK)-mediated IL-8 expression were investigated in cloned human monocytes and peripheral blood mononuclear cells (PBMC).	deoxynivalenol	43-57	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
16541418-8	2006	TGF-beta1 stimulated IL-8 expression in dose- and time-dependent manners, which was blocked by cycloheximide (CHX) and actinomycin D (ActD).	Cycloheximide	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
16364386-1	2006	The effects of the ribotoxic trichothecene deoxynivalenol (DON) on mitogen-activated protein kinase (MAPK)-mediated IL-8 expression were investigated in cloned human monocytes and peripheral blood mononuclear cells (PBMC).	deoxynivalenol	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
16364386-2	2006	DON (250 to 1000 ng/ml) induced both IL-8 mRNA and IL-8 heteronuclear RNA (hnRNA), an indicator of IL-8 transcription, in the human U937 monocytic cell line in a concentration-dependent manner.	deoxynivalenol	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
16364386-2	2006	DON (250 to 1000 ng/ml) induced both IL-8 mRNA and IL-8 heteronuclear RNA (hnRNA), an indicator of IL-8 transcription, in the human U937 monocytic cell line in a concentration-dependent manner.	deoxynivalenol	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
16541418-8	2006	TGF-beta1 stimulated IL-8 expression in dose- and time-dependent manners, which was blocked by cycloheximide (CHX) and actinomycin D (ActD).	Dactinomycin	119-132	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
16364386-2	2006	DON (250 to 1000 ng/ml) induced both IL-8 mRNA and IL-8 heteronuclear RNA (hnRNA), an indicator of IL-8 transcription, in the human U937 monocytic cell line in a concentration-dependent manner.	deoxynivalenol	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
16364386-3	2006	Expression of IL-8 hnRNA, mRNA and protein correlated with p38 phosphorylation and was completely abrogated by the p38 MAPK inhibitor SB203580.	SB 203580	134-142	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
16364386-4	2006	DON at 500 ng/ml similarly induced p38-dependent IL-8 protein and mRNA expression in PBMC cultures from healthy volunteers.	deoxynivalenol	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
16541418-8	2006	TGF-beta1 stimulated IL-8 expression in dose- and time-dependent manners, which was blocked by cycloheximide (CHX) and actinomycin D (ActD).	Dactinomycin	134-138	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
16414982-2	2006	Inhibition of the Erk MAPK, MEK, by U0126 produces a marked decrease in NaF-induced caldesmon phosphorylation.	U 0126	36-41	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
16620783-8	2006	IL-1beta-pretreated NT2-N induced the chemotaxis of PBMC, which was significantly reduced by anti-IL-8, but not by anti-MIP-1beta neutralizing antibody.	nt2-n	20-25	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
16684953-9	2006	The decay of IL-8 mRNA transcripts proceeded at a significantly faster rate when cells were pretreated with the p38 MAPK inhibitor SB-203580 (-0.05763 +/- 0.01964, t(1/2) = 12.0 h), compared with vehicle (-0.01030 +/- 0.007963, t(1/2) = 67.3 h) [results are expressed as decay constant (means +/- SE) and half-life (t(1/2) in h): P &lt; 0.05].	SB 203580	131-140	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
16414982-4	2006	Selective Raf-1 inhibitors (ZM-336372 and Raf-1 inhibitor 1) significantly attenuate NaF-induced Erk and caldesmon phosphorylation.	N-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamide	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
16414982-7	2006	Pretreatment with KN93, a specific CaMKII inhibitor, attenuates NaF-induced barrier dysfunction and Erk phosphorylation.	KN 93	18-22	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
16734624-8	2006	IL-8, GRO-alpha and ENA-78 synthesis was suppressed almost completely by AEBSF and BAY 11-7085, whereas prednisolone reduced chemokine levels differentially dependent on the supernatant added.	4-(2-aminoethyl)benzenesulfonylfluoride	73-78	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
16755003-0	2006	Inhibition of IL-8 production by green tea polyphenols in human nasal fibroblasts and A549 epithelial cells.	Polyphenols	43-54	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
16755003-8	2006	Tea polyphenols were very effective in the inhibition of IL-8 production.	Polyphenols	4-15	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
16755003-11	2006	Production of IL-8 after stimulation by proinflammatory cytokines in both nasal fibroblasts and bronchial epithelial cells was significantly blocked by pretreatment with green tea polyphenols.	Polyphenols	180-191	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
16736518-6	2006	RESULTS: ICs containing anti-CII from arthritis patients induced the production of tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and IL-8.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
16736518-9	2006	Anti-CII-containing IC-induced cytokine production was almost totally abolished (&gt;99%) after monocyte depletion, and receptor blocking studies showed significant decreases in the production of TNFalpha, IL-1beta, and IL-8 after blocking Fc gammaRIIa, but not after blocking Fc gammaRIII.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	5-8	C-X-C motif chemokine ligand 8	Homo sapiens	220-224
16778290-9	2006	In support, native and polymeric AAT-M with low endotoxin contamination completely inhibited neutrophil IL-8 release triggered by the zymosan, while AATs with high endotoxin contamination strongly induced IL-8 release and did not inhibit zymosan-stimulated IL-8 release.	Zymosan	134-141	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
16734624-8	2006	IL-8, GRO-alpha and ENA-78 synthesis was suppressed almost completely by AEBSF and BAY 11-7085, whereas prednisolone reduced chemokine levels differentially dependent on the supernatant added.	BAY 11-7085	83-94	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
16916238-2	2006	Acetic acid was added to a 0.1% NaF solution to make two solutions, one with pH 3.5 and the other with pH 6.	Acetic Acid	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
16955241-1	2006	OBJECTIVE: To investigate whether FK506 (tacrolimus) can inhibit Fas- or A23187-induced interleukin (IL)-8 expression and cell death in A549 human alveolar epithelial cells, plus Fas-mediated acute lung injury in vivo.	Tacrolimus	34-39	C-X-C motif chemokine ligand 8	Homo sapiens	88-106
16637007-5	2006	M-TriDAP induced IL-8/TNF-alpha secretion, and enhancement of LPS IL-1beta responses was significantly reduced between NOD2 double mutation carriers versus healthy controls, whereas there was no difference with FK565 or TriDAP stimulation, or between 1007fs/1007fs cells and other genotypes.	L-Ala-gamma-D-Glu-meso-diaminopimelic acid	2-8	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
16955241-1	2006	OBJECTIVE: To investigate whether FK506 (tacrolimus) can inhibit Fas- or A23187-induced interleukin (IL)-8 expression and cell death in A549 human alveolar epithelial cells, plus Fas-mediated acute lung injury in vivo.	Tacrolimus	41-51	C-X-C motif chemokine ligand 8	Homo sapiens	88-106
16955241-1	2006	OBJECTIVE: To investigate whether FK506 (tacrolimus) can inhibit Fas- or A23187-induced interleukin (IL)-8 expression and cell death in A549 human alveolar epithelial cells, plus Fas-mediated acute lung injury in vivo.	ammonium ferrous sulfate	65-68	C-X-C motif chemokine ligand 8	Homo sapiens	88-106
16955241-1	2006	OBJECTIVE: To investigate whether FK506 (tacrolimus) can inhibit Fas- or A23187-induced interleukin (IL)-8 expression and cell death in A549 human alveolar epithelial cells, plus Fas-mediated acute lung injury in vivo.	Calcimycin	73-79	C-X-C motif chemokine ligand 8	Homo sapiens	88-106
16687627-6	2006	Inhibition of these pathways with pyrrolidine dithiocarbamate, PD 98059, and fludarabine, respectively, attenuated GA-induced IL-8 secretion.	pyrrolidine dithiocarbamic acid	34-61	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
16750994-8	2006	The purinergic receptor antagonist suramin did block LL-37-induced ERK1/2 phosphorylation and IL-8 release, and expression of mRNA for the purinergic receptor P2X(7) was detected in HASM cells.	Suramin	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
16723453-7	2006	PD153035 reduced IL-8, AG1295 repressed IL-6, and both inhibitors partially downregulated VEGF production in UV-exposed PECs.	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
16687627-6	2006	Inhibition of these pathways with pyrrolidine dithiocarbamate, PD 98059, and fludarabine, respectively, attenuated GA-induced IL-8 secretion.	fludarabine	77-88	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
16723648-0	2006	Simvastatin decreases IL-6 and IL-8 production in epithelial cells.	Simvastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
16687627-7	2006	Rosiglitazone dose-dependently attenuated GA-induced IL-8 and ICAM-1 signals in PTEC and completely abolished GA-induced STAT-1 signals but had no effect on NF-kappaB and MAPK activation.	Rosiglitazone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
16723648-3	2006	Since oral epithelial cells participate importantly in periodontal inflammation, we measured simvastatin effects on interleukin-6 and interleukin-8 production by cultured human epithelial cell line (KB cells) in response to interleukin-1alpha.	Simvastatin	93-104	C-X-C motif chemokine ligand 8	Homo sapiens	134-147
16702304-0	2006	Glutamine pretreatment reduces IL-8 production in human intestinal epithelial cells by limiting IkappaBalpha ubiquitination.	Glutamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
16702304-3	2006	Because regulation of the inflammatory response was shown to be linked to proteolysis regulation, we hypothesized that glutamine pretreatment could act on IL-8 production in human intestinal epithelial cells through the regulation of inhibitor kappaB (IkappaB) ubiquitination.	Glutamine	119-128	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
16702304-6	2006	A pretreatment with 10 mmol/L glutamine decreased IL-8 production under both basal and proinflammatory conditions (both P &lt; 0.05).	Glutamine	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
16845446-0	2006	Inhibitive effect of genistein on interleukin-8 expression in cultured human retinal pigment epithelial cells.	Genistein	21-30	C-X-C motif chemokine ligand 8	Homo sapiens	34-47
16783450-2	2006	The aim of this study was to explore the effects of 2 second-generation antihistamines, cetirizine and loratadine, on granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-8 (IL-8) secretions in human airway epithelial cells.	Cetirizine	88-98	C-X-C motif chemokine ligand 8	Homo sapiens	180-193
16783450-2	2006	The aim of this study was to explore the effects of 2 second-generation antihistamines, cetirizine and loratadine, on granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-8 (IL-8) secretions in human airway epithelial cells.	Cetirizine	88-98	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
16783450-2	2006	The aim of this study was to explore the effects of 2 second-generation antihistamines, cetirizine and loratadine, on granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-8 (IL-8) secretions in human airway epithelial cells.	Loratadine	103-113	C-X-C motif chemokine ligand 8	Homo sapiens	180-193
16783450-2	2006	The aim of this study was to explore the effects of 2 second-generation antihistamines, cetirizine and loratadine, on granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-8 (IL-8) secretions in human airway epithelial cells.	Loratadine	103-113	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
16783450-5	2006	Cetirizine (5, 10 microM) inhibited the production of IL-8 by 19% (p&lt;0.05).	Cetirizine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
16845446-4	2006	When the cells were treated with hypoxia (5% CO2, 95% N2), IL-8 secretion increased from 0.29 +/- 0.04 to 2.59 +/- 0.42 ng/ml.	Nitrogen	54-56	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
16845446-5	2006	To study calcium-dependent IL-8 expression, cells were treated with KCl at 25 mM, norepinephrine (NE) at 10 nM, and glutamate (Glu) at 1 microM for 8 h. As a result, the levels of IL-8 protein in supernatants were significantly increased compared with that in the controls.	Calcium	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
16845446-6	2006	When the cells are treated with genistein (50, 100, 200 microM) for 30 min before hypoxia or stimulations by KCl, NE, and Glu, the elevated expression of IL-8 protein was all suppressed in a concentration-dependent manner.	Genistein	32-41	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
16845446-6	2006	When the cells are treated with genistein (50, 100, 200 microM) for 30 min before hypoxia or stimulations by KCl, NE, and Glu, the elevated expression of IL-8 protein was all suppressed in a concentration-dependent manner.	Potassium Chloride	109-112	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
16815071-6	2006	TsAg induced maximal nuclear binding of p65, p50 and c-rel subunits of the transcriptional regulator NF-kappaB by 2 h. IkappaBalpha but not IkappaBbeta was degraded within 10 min before resynthesis by 2 h. Pre-treatment with the broad-spectrum NF-kappaB inhibitor pyrrolidine dithiocarbamate caused complete abrogation of TsAg-induced CCL2 secretion (p=0.005) and 91% reduction of CXCL8 secretion (p=0.0003).	tsag	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	381-386
16845446-4	2006	When the cells were treated with hypoxia (5% CO2, 95% N2), IL-8 secretion increased from 0.29 +/- 0.04 to 2.59 +/- 0.42 ng/ml.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
16845446-6	2006	When the cells are treated with genistein (50, 100, 200 microM) for 30 min before hypoxia or stimulations by KCl, NE, and Glu, the elevated expression of IL-8 protein was all suppressed in a concentration-dependent manner.	Glutamic Acid	122-125	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
16845446-2	2006	In this study, the effects of genistein on the expression of IL-8 in the arising retinal pigment epithelia-19 cells were studied.	Genistein	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
16845446-7	2006	These results suggested that suppression of IL-8 expression in retinal pigment epithelial cells might partly account for the inhibitive effect of genistein on retinal neovascularization.	Genistein	146-155	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
16740161-16	2006	Treatment with CpG increased phosphorylation of p38 and pretreatment with the p38 inhibitor SB202190 attenuated the synergistic increase in IL-8 protein levels.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	92-100	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
16787522-1	2006	It has been reported that urinary interleukin-6 (IL-6) and IL-8 levels are decreased in adult diabetic women with asymptomatic bacteriuria (ASB) when compared with non-diabetic women with ASB.	asb	140-143	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
16787522-10	2006	Indeed, the IL-8 levels were higher in diabetic subjects with ASB as compared with those without it (70.0 vs. &lt;3.1 pg/mg creatinine; p = 0.001), and there was a significant association between the urinary IL-8 concentration and the bacterial count (p = 0.001).	asb	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
16787522-10	2006	Indeed, the IL-8 levels were higher in diabetic subjects with ASB as compared with those without it (70.0 vs. &lt;3.1 pg/mg creatinine; p = 0.001), and there was a significant association between the urinary IL-8 concentration and the bacterial count (p = 0.001).	asb	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
16787522-10	2006	Indeed, the IL-8 levels were higher in diabetic subjects with ASB as compared with those without it (70.0 vs. &lt;3.1 pg/mg creatinine; p = 0.001), and there was a significant association between the urinary IL-8 concentration and the bacterial count (p = 0.001).	Creatinine	124-134	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
16787522-11	2006	Diabetic patients with leukocyturia had higher IL-8 concentration than those without it (20.9 vs. &lt;3.1 pg/mg creatinine; p = 0.003).	Creatinine	112-122	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
16787522-15	2006	Our results suggest that diabetic children with ASB mount an IL-8 response to pathogens, which is comparable to non-diabetic children with bacteriuria.	asb	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
16641218-4	2006	F2-isoprostane levels (a marker of oxidant injury) in tracheal aspirates were significantly higher in the cimetidine group at 4 d and at 10 d. There were no significant differences between the groups in tracheal aspirate levels of inflammatory markers (leukotriene B4, IL-8, and nucleated cell count) or arachidonic acid metabolites.	Cimetidine	106-116	C-X-C motif chemokine ligand 8	Homo sapiens	269-273
16739069-5	2006	GTE significantly induced IL-8 mRNA expression, which was not mediated indirectly via an induction of IL-1beta mRNA expression.	epigallocatechin gallate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
16739069-6	2006	EGCG only exerted a weak although significant induction of IL-8 mRNA expression at the highest concentration.	epigallocatechin gallate	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
16739069-8	2006	GTE and EGCG significantly decreased secreted IL-8 concentrations.	epigallocatechin gallate	8-12	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
16739069-10	2006	The IL-1beta-mediated increase of IL-8 secretion was significantly inhibited by GTE in a dose-dependent manner.	epigallocatechin gallate	80-83	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
16427093-6	2006	Inhibition of the EGFR by either an anti-EGFR neutralizing antibody or by its specific inhibitor AG1478 (1 microM) blocked TNF-alpha-induced IL-8 secretion.	RTKI cpd	97-103	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
16690053-1	2006	Human chymase induced release of interleukin-8 (IL-8) in human EoL-1 cells that had been differentiated into eosinophil-like cells with butyric acid.	Butyric Acid	136-148	C-X-C motif chemokine ligand 8	Homo sapiens	33-46
16690053-1	2006	Human chymase induced release of interleukin-8 (IL-8) in human EoL-1 cells that had been differentiated into eosinophil-like cells with butyric acid.	Butyric Acid	136-148	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
16690053-4	2006	The chymase-induced IL-8 release was inhibited by pertussis toxin as well as U0126 (an inhibitor for extracellular signal-regulated kinase pathway) and SB203580 (p38 inhibitor), suggesting that the chymase-induced IL-8 production is mediated by G protein-coupled receptor and mitogen-activated protein kinases.	U 0126	77-82	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
16690053-4	2006	The chymase-induced IL-8 release was inhibited by pertussis toxin as well as U0126 (an inhibitor for extracellular signal-regulated kinase pathway) and SB203580 (p38 inhibitor), suggesting that the chymase-induced IL-8 production is mediated by G protein-coupled receptor and mitogen-activated protein kinases.	SB 203580	152-160	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
16690053-4	2006	The chymase-induced IL-8 release was inhibited by pertussis toxin as well as U0126 (an inhibitor for extracellular signal-regulated kinase pathway) and SB203580 (p38 inhibitor), suggesting that the chymase-induced IL-8 production is mediated by G protein-coupled receptor and mitogen-activated protein kinases.	SB 203580	152-160	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
16764700-2	2006	The aim of the study is to analyse the expression of pro-inflammatory cytokines IL-1beta, TNF-alpha, IFN-gamma and the chemokine CXCL8 (IL-8) in liver tissue and their expression and secretion in PBMC of patients with chronic hepatitis C (CHC), in response to pentoxyfilline (PTX).	Pentoxifylline	260-274	C-X-C motif chemokine ligand 8	Homo sapiens	129-134
16764700-2	2006	The aim of the study is to analyse the expression of pro-inflammatory cytokines IL-1beta, TNF-alpha, IFN-gamma and the chemokine CXCL8 (IL-8) in liver tissue and their expression and secretion in PBMC of patients with chronic hepatitis C (CHC), in response to pentoxyfilline (PTX).	Pentoxifylline	260-274	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
16764700-2	2006	The aim of the study is to analyse the expression of pro-inflammatory cytokines IL-1beta, TNF-alpha, IFN-gamma and the chemokine CXCL8 (IL-8) in liver tissue and their expression and secretion in PBMC of patients with chronic hepatitis C (CHC), in response to pentoxyfilline (PTX).	Pentoxifylline	276-279	C-X-C motif chemokine ligand 8	Homo sapiens	129-134
16764700-2	2006	The aim of the study is to analyse the expression of pro-inflammatory cytokines IL-1beta, TNF-alpha, IFN-gamma and the chemokine CXCL8 (IL-8) in liver tissue and their expression and secretion in PBMC of patients with chronic hepatitis C (CHC), in response to pentoxyfilline (PTX).	Pentoxifylline	276-279	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
16764700-6	2006	Following PTX, PBMC exhibited a decrease in IFN-gamma mRNA 12.2 versus 1.5 molecules (P = 0.028) and CXCL8 4.2 versus 2.5 molecules (P = 0.027).	Pentoxifylline	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	101-106
16388870-6	2006	Addition of p38 MAPK inhibitor, SB-203580 and NF-kappaB inhibitor Bay 11-7082, suppressed IBDV-induced NO production and mRNA expression of iNOS, IL-8 and COX-2.	SB 203580	32-41	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
16388870-6	2006	Addition of p38 MAPK inhibitor, SB-203580 and NF-kappaB inhibitor Bay 11-7082, suppressed IBDV-induced NO production and mRNA expression of iNOS, IL-8 and COX-2.	3-(4-methylphenylsulfonyl)-2-propenenitrile	66-77	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
16427093-10	2006	Finally, both AR and IL-8 release-induced by TNF-alpha were eliminated by pretreatment with either GM6001, a broad-spectrum inhibitor for metalloprotease, or TAPI-1, relatively selective inhibitor for TNF-alpha converting enzyme (TACE).	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	99-105	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
16707595-4	2006	EXPERIMENTAL DESIGN: The effects of dexamethasone on VEGF and IL-8 expression and cell proliferation were examined using DU145, which expresses glucocorticoid receptor.	Dexamethasone	36-49	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
16707595-6	2006	RESULTS: Dexamethasone significantly down-regulated VEGF and IL-8 gene expression by 50% (P &lt; 0.001) and 89% (P &lt; 0.001), respectively, and decreased VEGF and IL-8 protein production by 55% (P &lt; 0.001) and 74% (P &lt; 0.001), respectively, under normoxic condition.	Dexamethasone	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
16707595-6	2006	RESULTS: Dexamethasone significantly down-regulated VEGF and IL-8 gene expression by 50% (P &lt; 0.001) and 89% (P &lt; 0.001), respectively, and decreased VEGF and IL-8 protein production by 55% (P &lt; 0.001) and 74% (P &lt; 0.001), respectively, under normoxic condition.	Dexamethasone	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
16707595-7	2006	Similarly, hydrocortisone down-regulated VEGF and IL-8 gene expression.	Hydrocortisone	11-25	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
16707595-9	2006	Even under hypoxia-like conditions, dexamethasone inhibited VEGF and IL-8 expression.	Dexamethasone	36-49	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
16376386-0	2006	Scoparone inhibits PMA-induced IL-8 and MCP-1 production through suppression of NF-kappaB activation in U937 cells.	scoparone	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
16707595-10	2006	In DU145 xenografts, dexamethasone significantly decreased tumor volume and microvessel density and down-regulated VEGF and IL-8 gene expression, whereas dexamethasone did not affect the in vitro proliferation of the cells.	Dexamethasone	21-34	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
16376386-0	2006	Scoparone inhibits PMA-induced IL-8 and MCP-1 production through suppression of NF-kappaB activation in U937 cells.	Tetradecanoylphorbol Acetate	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
16353157-6	2006	We show that phenoxodiol inhibits hallmarks of endothelial cell activation, namely TNF or IL-1 induced E-selectin and VCAM-1 expression and IL-8 secretion.	phenoxodiol	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
16424382-11	2006	Fluticasone alone reduced CCL5, CXCL8, and CXCL10 but had no effect on CXCL5.	Fluticasone	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	32-37
16373669-0	2006	Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells.	Zinc	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
16373669-3	2006	In this study, we examined the cellular mechanisms responsible for Zn(2+)-induced IL-8 expression.	Zinc	67-69	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
16373669-4	2006	Zn(2+) stimulation resulted in pronounced increases in both IL-8 mRNA and protein expression in the human airway epithelial cell line (BEAS-2B).	Zinc	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
16373669-5	2006	IL-8 promoter activity was significantly increased by Zn(2+) exposure in BEAS-2B cells, indicating that Zn(2+)-induced IL-8 expression is transcriptionally mediated.	Zinc	54-56	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
16376386-2	2006	In this study, the effects of scoparone on the expression of interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) and activation of nuclear factor-kappaB (NF-kappaB) were examined in U937 human monocytes activated with phorbol 12-myristate 13-acetate (PMA).	scoparone	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
16376386-2	2006	In this study, the effects of scoparone on the expression of interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) and activation of nuclear factor-kappaB (NF-kappaB) were examined in U937 human monocytes activated with phorbol 12-myristate 13-acetate (PMA).	scoparone	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
16376386-4	2006	Scoparone concentration-dependently reduced the release of IL-8 and MCP-1 protein and expression of IL-8 and MCP-1 mRNA levels induced by PMA.	scoparone	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
16376386-4	2006	Scoparone concentration-dependently reduced the release of IL-8 and MCP-1 protein and expression of IL-8 and MCP-1 mRNA levels induced by PMA.	scoparone	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
16373669-8	2006	We observed that Zn(2+) exposure induced the phosphorylation of ERK, JNK, and p38 MAPKs, whereas inhibition of ERK or JNK activity blocked IL-8 mRNA and protein expression in BEAS-2B cells treated with Zn(2+).	Zinc	17-19	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
16373669-11	2006	These results suggested that Zn(2+)-induced inhibition of phosphatase activity is an initiating event in MAPK and AP-1 activation that leads to enhanced IL-8 expression by human airway epithelial cells.	Zinc	29-35	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
16373669-5	2006	IL-8 promoter activity was significantly increased by Zn(2+) exposure in BEAS-2B cells, indicating that Zn(2+)-induced IL-8 expression is transcriptionally mediated.	Zinc	54-56	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
16373669-5	2006	IL-8 promoter activity was significantly increased by Zn(2+) exposure in BEAS-2B cells, indicating that Zn(2+)-induced IL-8 expression is transcriptionally mediated.	Zinc	104-106	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
16421230-6	2006	When epithelial cells were incubated with polyinosine-polycytidylic acid and CpG oligodinucleotides, we observed dose-dependent upregulation of interleukin-8 secretion.	polyinosine-polycytidylic acid	42-72	C-X-C motif chemokine ligand 8	Homo sapiens	144-157
16373669-5	2006	IL-8 promoter activity was significantly increased by Zn(2+) exposure in BEAS-2B cells, indicating that Zn(2+)-induced IL-8 expression is transcriptionally mediated.	Zinc	104-106	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
16137694-7	2006	Rosiglitazone reduced the incremental area under the curves (dAUCs) for IL-6 (-63%, p&lt;0.01) and IL-8 (-16%, p&lt;0.05).	Rosiglitazone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
16137694-9	2006	CONCLUSIONS: Rosiglitazone attenuated the postprandial increases of neutrophils, IL-6 and IL-8 in patients with type 2 diabetes.	Rosiglitazone	13-26	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
16137694-12	2006	Rosiglitazone attenuated the postprandial increases of neutrophils, IL-6 and IL-8 in patients with type 2 diabetes.	Rosiglitazone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
16631683-8	2006	Subgroup analysis revealed a significantly greater elevation in IL-6, IL-8, and IL-10 levels in PGF patients (all p &lt; 0.01) versus PLTRE.	Prostaglandins F	96-99	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
16631683-10	2006	CONCLUSIONS: Patients with PLTRE and PGF exhibited graded increases in IL-6, IL-8, and IL-10 concentrations.	Prostaglandins F	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
16421230-6	2006	When epithelial cells were incubated with polyinosine-polycytidylic acid and CpG oligodinucleotides, we observed dose-dependent upregulation of interleukin-8 secretion.	cpg oligodinucleotides	77-99	C-X-C motif chemokine ligand 8	Homo sapiens	144-157
16604541-8	2006	RESULTS: All oxysterols investigated are potent in vitro inducers of MCP-1, MIP-1beta, TNF-alpha, and/or IL-8 secretion, the latter involving the MEK/ERK1/2 cell signaling pathway.	Oxysterols	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
16634798-10	2006	PD98059, an inhibitor of ERK phosphorylation, significantly reduced IgA AECA-stimulated endothelial IL-8.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
16675585-8	2006	RESULTS: Candesartan did not induce direct toxicity in KU-19-19 cells, but VEGF and interleukin-8 were significantly lower in candesartan-treated cells (2.55 +/- 0.25 and 6.58 +/- 0.48 pg/10(3) cells) than in the angiotensin II-treated control cells (3.16 +/- 0.42 and 7.91 +/- 0.69 pg/10(3) cells).	candesartan	126-137	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
16670485-8	2006	In primary cultures, 17beta-estradiol caused a significant decrease of IL-6 and IL-8 gene expression, but had no effect on the levels of IL-1beta, MMP-2, and MMP-9 gene expression.	Estradiol	21-37	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
16289596-10	2006	LPA induced significant migration and IL-8 secretion in DLD1, both of which were significantly inhibited by AG1478 or GM6001.	lysophosphatidic acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
16546701-2	2006	In this paper, we show that fludarabine can also induce pro-inflammatory stimulation of monocytic cells, as evaluated by increased expression of ICAM-1 and IL-8 release.	fludarabine	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
16716121-6	2006	Pretreatment of HBECs with specific inhibitors against ERK 1/2 and JNK but not p38 could significantly inhibit nicotine-induced interleukin- 8 production.	Nicotine	111-119	C-X-C motif chemokine ligand 8	Homo sapiens	128-142
16622236-7	2006	The IL-8 secretion in response to P. aeruginosa DNA was decreased by treatments that inhibit acidification of intracellular organelles, using chloroquine, a pH-neutralizing compound, or bafilomycin A1, an inhibitor of vacuolar H+-ATPase.	Chloroquine	142-153	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
16622236-7	2006	The IL-8 secretion in response to P. aeruginosa DNA was decreased by treatments that inhibit acidification of intracellular organelles, using chloroquine, a pH-neutralizing compound, or bafilomycin A1, an inhibitor of vacuolar H+-ATPase.	bafilomycin A1	186-200	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
16410784-4	2006	Addition of the hydrolysis-resistant ATP analogue, adenosine 5"-O-(3-thiotriphosphate) (ATPgammaS), to subconfluent cultures of the human microvascular endothelial cell-1 (HMEC-1) cell line led to a dose- and time-dependent increase in release of IL-6, IL-8, monocyte chemoattractant protein-1, and growth-regulated oncogene alpha.	adenosine 5'-O-(3-thiotriphosphate)	51-86	C-X-C motif chemokine ligand 8	Homo sapiens	253-257
16652423-6	2006	Stimulation of neutrophils with formyl-methionine-leucine-phenylalanine, IL-8, and LTB4 inhibited subsequent mobilization of calcium by the supernatant.	Calcium	125-132	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
16289596-10	2006	LPA induced significant migration and IL-8 secretion in DLD1, both of which were significantly inhibited by AG1478 or GM6001.	RTKI cpd	108-114	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
16289596-10	2006	LPA induced significant migration and IL-8 secretion in DLD1, both of which were significantly inhibited by AG1478 or GM6001.	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	118-124	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
16406095-7	2006	Histamine and poly (I:C), a specific TLR3 ligand stimulated interleukin (IL)-8 secretion from both cell types.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	60-78
16641879-7	2006	RESULTS: There was a significant correlation between IL-8 concentration and AST, ALP, GGT, total bilirubin and albumin levels in blood serum.	Bilirubin	97-106	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
16406095-7	2006	Histamine and poly (I:C), a specific TLR3 ligand stimulated interleukin (IL)-8 secretion from both cell types.	Carbon	22-23	C-X-C motif chemokine ligand 8	Homo sapiens	60-78
16406095-8	2006	Moreover, histamine enhanced poly (I:C)-induced IL-8 secretion and phosphorylation of NF-kappaB in the two cell types, and histamine H1 receptor antagonists inhibited the action of histamine.	Histamine	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
16406095-7	2006	Histamine and poly (I:C), a specific TLR3 ligand stimulated interleukin (IL)-8 secretion from both cell types.	poly	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	60-78
16406095-8	2006	Moreover, histamine enhanced poly (I:C)-induced IL-8 secretion and phosphorylation of NF-kappaB in the two cell types, and histamine H1 receptor antagonists inhibited the action of histamine.	Poly I-C	29-39	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
16406095-9	2006	In conclusion, histamine selectively up-regulated expression of TLR3, and stimulated IL-8 secretion from the cells.	Histamine	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
16585276-11	2006	To avoid dilution effects, urinary levels of IL-8 were expressed as the ratio of cytokine-to-urinary creatinine.	Creatinine	101-111	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
16406095-10	2006	Histamine also enhanced poly (I:C) induced IL-8 secretion and phosphorylation of NF-kappaB.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
16406095-10	2006	Histamine also enhanced poly (I:C) induced IL-8 secretion and phosphorylation of NF-kappaB.	Poly I-C	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
16326104-0	2006	Sesquiterpene lactones as inhibitors of IL-8 expression in HeLa cells.	sesquiterpene lactones	0-22	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
16529714-8	2006	SbS also inhibited IL-8 production, prevented IkappaB alpha degradation, and reduced both NF-kappaB-DNA binding and NF-kappaB reporter gene up-regulation in IL-1beta or LPS-stimulated THP-1 cells.	sbs	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
16552751-8	2006	Pretreatment with BAPTA/AM or GF109203X also significantly attenuated ghrelin-induced IL-8 production.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	18-23	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
16552751-8	2006	Pretreatment with BAPTA/AM or GF109203X also significantly attenuated ghrelin-induced IL-8 production.	bisindolylmaleimide I	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
16600024-8	2006	Phorbol myristate acetate-stimulated oxidative burst and IL-8 release by IL-1beta, lipopolysaccharide and GM-CSF in whole blood from mild but not severe asthmatics were inhibited after prednisolone.	Tetradecanoylphorbol Acetate	0-25	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
16600024-8	2006	Phorbol myristate acetate-stimulated oxidative burst and IL-8 release by IL-1beta, lipopolysaccharide and GM-CSF in whole blood from mild but not severe asthmatics were inhibited after prednisolone.	Prednisolone	185-197	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
16570973-0	2006	Raman spectra of ionic liquids: a simulation study of AlF3 and its mixtures with NaF.	aluminum fluoride	54-58	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
16322472-5	2006	HNP-induced IL-8 release was inhibited by treatment with the nucleotide receptor antagonists suramin and reactive blue.	Suramin	93-100	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
16570973-1	2006	Theoretical Raman spectra of the melts of NaF/AlF3 mixtures have been obtained from computer simulations in order to examine how the Raman spectra reflect the coordination structure around the Al3+ ions.	ALUMINUM ION	193-197	C-X-C motif chemokine ligand 8	Homo sapiens	42-45
16572448-8	2006	When hemoglobin, as a scavenger of carbon monoxide, was added to auranofin-treated synovial cell lines, LPS-dependent production of IL-6 and IL-8 was increased.	Carbon Monoxide	35-50	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
16572448-8	2006	When hemoglobin, as a scavenger of carbon monoxide, was added to auranofin-treated synovial cell lines, LPS-dependent production of IL-6 and IL-8 was increased.	Auranofin	65-74	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
16322472-5	2006	HNP-induced IL-8 release was inhibited by treatment with the nucleotide receptor antagonists suramin and reactive blue.	reactive blue	105-118	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
16217757-8	2006	VEGF-induced IL-8 production at the mRNA (real time RT-PCR) and protein levels (ELISA) are also suppressed with EGCG.	epigallocatechin gallate	112-116	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
16517565-0	2006	Effects of combined 17beta-estradiol with TCDD on secretion of chemokine IL-8 and expression of its receptor CXCR1 in endometriotic focus-associated cells in co-culture.	Estradiol	20-36	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
16517565-0	2006	Effects of combined 17beta-estradiol with TCDD on secretion of chemokine IL-8 and expression of its receptor CXCR1 in endometriotic focus-associated cells in co-culture.	Polychlorinated Dibenzodioxins	42-46	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
16517565-4	2006	The regulatory mechanisms of dioxin and estrogen in the expression of CXCR1/IL-8 in the corresponding cells will help in elucidating roles of the chemokine in the aetiology of endometriosis.	Dioxins	29-35	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
16517565-8	2006	TCDD promoted IL-8 secretion by human pelvic mesothelial cells (HPMC), and 17beta-estradiol magnified the stimulatory effect.	Polychlorinated Dibenzodioxins	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
16202406-11	2006	SB202190, PD98059 and doxycycline markedly suppressed the levels of p-JNK-1/p-JNK-2 and/or p-ERK1/p-ERK2, as well as IL-1beta, TNF-alpha and IL-8 mRNAs and proteins stimulated by hyperosmolar media.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
16202406-11	2006	SB202190, PD98059 and doxycycline markedly suppressed the levels of p-JNK-1/p-JNK-2 and/or p-ERK1/p-ERK2, as well as IL-1beta, TNF-alpha and IL-8 mRNAs and proteins stimulated by hyperosmolar media.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	10-17	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
16202406-11	2006	SB202190, PD98059 and doxycycline markedly suppressed the levels of p-JNK-1/p-JNK-2 and/or p-ERK1/p-ERK2, as well as IL-1beta, TNF-alpha and IL-8 mRNAs and proteins stimulated by hyperosmolar media.	Doxycycline	22-33	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
16517565-11	2006	Interaction of HPMC and the monocytes significantly stimulated IL-8 secretion, suggesting a main resource of IL-8 in peritoneal cavity with endometriosis.	hydroxypropylmethylcellulose-lactose matrix	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
16517565-11	2006	Interaction of HPMC and the monocytes significantly stimulated IL-8 secretion, suggesting a main resource of IL-8 in peritoneal cavity with endometriosis.	hydroxypropylmethylcellulose-lactose matrix	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
16517565-12	2006	TCDD promoted IL-8 secretion by HPMC-U937 co-culture, but exerted a contrary effect for IL-8 secretion when combined with estradiol.	Polychlorinated Dibenzodioxins	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
16517565-12	2006	TCDD promoted IL-8 secretion by HPMC-U937 co-culture, but exerted a contrary effect for IL-8 secretion when combined with estradiol.	Polychlorinated Dibenzodioxins	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
16517565-12	2006	TCDD promoted IL-8 secretion by HPMC-U937 co-culture, but exerted a contrary effect for IL-8 secretion when combined with estradiol.	hydroxypropylmethylcellulose-lactose matrix	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
16517565-8	2006	TCDD promoted IL-8 secretion by human pelvic mesothelial cells (HPMC), and 17beta-estradiol magnified the stimulatory effect.	hydroxypropylmethylcellulose-lactose matrix	64-68	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
16517565-9	2006	Both 17beta-estradiol and TCDD alone inhibited IL-8 secretion of U937 (a cell line of monocyte), but combination of 17beta-estradiol and TCDD had no further inhibitory effect.	Estradiol	5-21	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
16270354-7	2006	In turn, exposure of B-CLL cells to recombinant IL-8 significantly decreased spontaneous apoptosis as well as chlorambucil- and fludarabine-mediated cytoxicity in B-CLL cells.	Chlorambucil	110-122	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
16517565-9	2006	Both 17beta-estradiol and TCDD alone inhibited IL-8 secretion of U937 (a cell line of monocyte), but combination of 17beta-estradiol and TCDD had no further inhibitory effect.	Polychlorinated Dibenzodioxins	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
16517565-10	2006	The co-culture of endometrial stromal cells (ESC) with HPMC produced more IL-8 than respective or total production of either of the cells alone, and estradiol played a synergistic stimulatory role with TCDD in IL-8 secretion of the co-culture.	hydroxypropylmethylcellulose-lactose matrix	55-59	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
16517565-10	2006	The co-culture of endometrial stromal cells (ESC) with HPMC produced more IL-8 than respective or total production of either of the cells alone, and estradiol played a synergistic stimulatory role with TCDD in IL-8 secretion of the co-culture.	hydroxypropylmethylcellulose-lactose matrix	55-59	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
16517565-10	2006	The co-culture of endometrial stromal cells (ESC) with HPMC produced more IL-8 than respective or total production of either of the cells alone, and estradiol played a synergistic stimulatory role with TCDD in IL-8 secretion of the co-culture.	Estradiol	149-158	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
16517565-10	2006	The co-culture of endometrial stromal cells (ESC) with HPMC produced more IL-8 than respective or total production of either of the cells alone, and estradiol played a synergistic stimulatory role with TCDD in IL-8 secretion of the co-culture.	Polychlorinated Dibenzodioxins	202-206	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
16392133-2	2006	We have previously reported that titanium particles stimulate the selective induction of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) chemokines in human osteoblast-like osteosarcoma cells.	Titanium	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	89-102
16392133-2	2006	We have previously reported that titanium particles stimulate the selective induction of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) chemokines in human osteoblast-like osteosarcoma cells.	Titanium	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
16392133-4	2006	We demonstrate that titanium particles result in enhanced IL-8 and MCP-1 protein secretion as well as differential chemokine gene activation.	Titanium	20-28	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
16392133-8	2006	We also demonstrate that while cytochalasin D, a potent inhibitor of phagocytosis, suppressed the titanium particle effect on IL-8 protein release in human bone marrow-derived osteoblasts, the inhibitor had no effect on IL-8 expression in MG-63 osteoblast-like cells.	Cytochalasin D	31-45	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
16392133-8	2006	We also demonstrate that while cytochalasin D, a potent inhibitor of phagocytosis, suppressed the titanium particle effect on IL-8 protein release in human bone marrow-derived osteoblasts, the inhibitor had no effect on IL-8 expression in MG-63 osteoblast-like cells.	Titanium	98-106	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
16331685-0	2006	Cardiac glycoside inhibits IL-8-induced biological responses by downregulating IL-8 receptors through altering membrane fluidity.	Glycosides	8-17	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
16331685-0	2006	Cardiac glycoside inhibits IL-8-induced biological responses by downregulating IL-8 receptors through altering membrane fluidity.	Glycosides	8-17	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
16331685-2	2006	In this report we provide evidences that oleandrin, a cardiac glycoside potentially inhibited IL-8-, formyl peptide (FMLP)-, EGF-, or nerve growth factor (NGF)-, but not IL-1- or TNF-induced NF-kappaB activation in macrophages.	oleandrin	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
16331685-2	2006	In this report we provide evidences that oleandrin, a cardiac glycoside potentially inhibited IL-8-, formyl peptide (FMLP)-, EGF-, or nerve growth factor (NGF)-, but not IL-1- or TNF-induced NF-kappaB activation in macrophages.	Glycosides	62-71	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
16331685-3	2006	Oleandrin inhibited IL-8-, but not TNF-induced NF-kappaB-dependent genes expression.	oleandrin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
16331685-4	2006	Oleandrin inhibited the binding of IL-8, EGF, or NGF, but not IL-1 or TNF.	oleandrin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
16331685-7	2006	Phospholipids significantly protected oleandrin-mediated inhibition of IL-8 binding thereby restoring IL-8-induced NF-kappaB activation.	Phospholipids	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
16270354-7	2006	In turn, exposure of B-CLL cells to recombinant IL-8 significantly decreased spontaneous apoptosis as well as chlorambucil- and fludarabine-mediated cytoxicity in B-CLL cells.	fludarabine	128-139	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
16331685-7	2006	Phospholipids significantly protected oleandrin-mediated inhibition of IL-8 binding thereby restoring IL-8-induced NF-kappaB activation.	Phospholipids	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
16331685-7	2006	Phospholipids significantly protected oleandrin-mediated inhibition of IL-8 binding thereby restoring IL-8-induced NF-kappaB activation.	oleandrin	38-47	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
16331685-7	2006	Phospholipids significantly protected oleandrin-mediated inhibition of IL-8 binding thereby restoring IL-8-induced NF-kappaB activation.	oleandrin	38-47	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
16549444-6	2006	Notably, the degree of inhibition of IL-8 release from HUVEC by HDL3 was correlated with the ability of HDL3 to promote cholesterol efflux (r = -0.80, P = 0.03).	Cholesterol	120-131	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
16683673-0	2006	Evaluation of fluoride release from teeth after topical application of NaF, SnF2 and APF and antimicrobial activity on mutans streptococci.	Fluorides	14-22	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
16683673-1	2006	UNLABELLED: The objectives of this study were to evaluate and compare the amount and pattern of fluoride release from teeth after topical application of 2% NaF, 8% SnF2 and 1.23% APF at different time intervals.	Fluorides	96-104	C-X-C motif chemokine ligand 8	Homo sapiens	156-159
16780654-6	2006	The expressions of TNF-alpha and IL-8 and their protein quantity in lung tissues significantly increased in LMV after ventilation compared to that in CMV and NMV (P &lt; 0.01).	lmv	108-111	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
16434099-5	2006	Furthermore, IL-8 induction could be blocked by brefeldin A, which inhibits ricin translocation into the cytosol.	Brefeldin A	48-59	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
16434099-7	2006	Treatment of 28SC cells with the pyridylimidizole analogue SB203580, a known inhibitor of p38 MAPK, suppressed ricin-mediated IL-8 release.	pyridylimidizole	33-49	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
16434099-7	2006	Treatment of 28SC cells with the pyridylimidizole analogue SB203580, a known inhibitor of p38 MAPK, suppressed ricin-mediated IL-8 release.	SB 203580	59-67	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
16481221-5	2006	Hypoxia (1% O2) up-regulated vascular endothelial growth factor-A (VEGF-A) but, unexpectedly, it decreased interleukin-8 (IL-8) and placenta growth factor (PlGF) expression.	Oxygen	12-14	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
16481221-6	2006	Atorvastatin (0.1-1 microM) attenuated PlGF in HMEC-1 in normoxia while it decreased VEGF-A and IL-8 production both in normoxia and hypoxia.	Atorvastatin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
16497987-6	2006	These studies also demonstrated that pretreatment of EC with NOS inhibitor, Nomega-nitro-L-arginine-methyl ester (L-NAME), significantly inhibited Ox-PAPC-induced IL-8 synthesis.	NG-Nitroarginine Methyl Ester	76-112	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
16497987-6	2006	These studies also demonstrated that pretreatment of EC with NOS inhibitor, Nomega-nitro-L-arginine-methyl ester (L-NAME), significantly inhibited Ox-PAPC-induced IL-8 synthesis.	NG-Nitroarginine Methyl Ester	114-120	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
16331685-9	2006	Overall, our results suggest that oleandrin inhibits IL-8-mediated biological responses in diverse cell types by modulating IL-8Rs through altering membrane fluidity and microviscosity.	oleandrin	34-43	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
16780654-6	2006	The expressions of TNF-alpha and IL-8 and their protein quantity in lung tissues significantly increased in LMV after ventilation compared to that in CMV and NMV (P &lt; 0.01).	nmv	158-161	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
16254130-5	2006	WBH induced an increase in human growth hormone (hGH), ACTH, and cortisol as well as in TNF-alpha, IL-6, IL-8, and IL-12R.	wbh	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
16647268-0	2006	Increased NaCl-induced interleukin-8 production by human bronchial epithelial cells is enhanced by the DeltaF508/W1282X mutation of the cystic fibrosis transmembrane conductance regulator gene.	Sodium Chloride	10-14	C-X-C motif chemokine ligand 8	Homo sapiens	23-36
16647268-6	2006	Human bronchial epithelial cells with the DeltaF508/W1282X CFTR mutation produce an exaggerated amount of basal and NaCl-induced IL-8.	Sodium Chloride	116-120	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
16479515-7	2006	CXCL-8 mRNA was superinduced by TNF- alpha in the presence of the protein-synthesis inhibitor cycloheximide.	Cycloheximide	94-107	C-X-C motif chemokine ligand 8	Homo sapiens	0-6
16564702-12	2006	However, in endothelial cells stimulated with ATP, the released fraction was effective in attenuating IL-1beta activation of the IL-8 reporter.	Adenosine Triphosphate	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
16553947-4	2006	Glucan phosphate-treated leukocytes induced a substantial amount of IL-8 (peak at 18 h: 5000 pg/ml), likely due to binding of NFkappaB to a consensus site in the IL-8 promoter.	glucan phosphate	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
16553947-4	2006	Glucan phosphate-treated leukocytes induced a substantial amount of IL-8 (peak at 18 h: 5000 pg/ml), likely due to binding of NFkappaB to a consensus site in the IL-8 promoter.	glucan phosphate	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
16553947-5	2006	An increase in IL-1receptor antagonist (RA) production (peak at 24 h: 12000 pg/ml) by glucan phosphate-treated cells positively correlated with IL-8 levels.	glucan phosphate	86-102	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
16509590-6	2006	A collection of analytically defined lipolanthionine peptide amides exhibited an inhibitory effect of the TLR2-mediated IL-8 secretion when applied in high molar excess to the agonistic synthetic lipopeptide Pam3Cys-Ser-(Lys)4-OH.	lipolanthionine peptide amides	37-67	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
16509590-6	2006	A collection of analytically defined lipolanthionine peptide amides exhibited an inhibitory effect of the TLR2-mediated IL-8 secretion when applied in high molar excess to the agonistic synthetic lipopeptide Pam3Cys-Ser-(Lys)4-OH.	Lysine	221-225	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
16509590-6	2006	A collection of analytically defined lipolanthionine peptide amides exhibited an inhibitory effect of the TLR2-mediated IL-8 secretion when applied in high molar excess to the agonistic synthetic lipopeptide Pam3Cys-Ser-(Lys)4-OH.	4-oh	225-229	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
16623401-6	2006	RESULTS: For patients in the LFA group, production of IL-8 was significantly less increased at the end of the surgical procedure; however there was no significant difference in total production between groups.	lfa	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
16249253-4	2006	High glucose also increased the specific binding of (125)I-labeled insulin in HAEC accompanied by accelerated production of interleukin (IL)-6 and IL-8.	Glucose	5-12	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
16527606-4	2006	IL-6 and IL-8 secretion was greater in coincubates of aCTL cells with 13-06-ISP and 13-06-CSP immunoselected cells than those with 13-06-MG parental cells.	13-06-isp	70-79	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
16385087-4	2006	METHODS AND RESULTS: Metformin dose-dependently inhibited IL-1beta-induced release of the pro-inflammatory cytokines IL-6 and IL-8 in ECs, SMCs, and Mphis.	Metformin	21-30	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
16521278-0	2006	Lipoteichoic acid (LTA) from Staphylococcus aureus stimulates human neutrophil cytokine release by a CD14-dependent, Toll-like-receptor-independent mechanism: Autocrine role of tumor necrosis factor-[alpha] in mediating LTA-induced interleukin-8 generation.	lipoteichoic acid	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	232-245
16423909-6	2006	RESULTS: We found the following associations with plasma marker concentrations: Age, neutrophil count, and glucose concentration were positively associated with IL-8 concentrations in children and adults, as were smoking and platelet count in adults.	Glucose	107-114	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
16505650-8	2006	MEASUREMENT AND MAIN RESULTS: Postoperative serum levels of both interleukin-6 and interleukin-8 increased significantly over baseline, but the peak levels observed 4 hrs postoperatively were significantly lower in the atorvastatin group.	Atorvastatin	219-231	C-X-C motif chemokine ligand 8	Homo sapiens	83-96
16521278-0	2006	Lipoteichoic acid (LTA) from Staphylococcus aureus stimulates human neutrophil cytokine release by a CD14-dependent, Toll-like-receptor-independent mechanism: Autocrine role of tumor necrosis factor-[alpha] in mediating LTA-induced interleukin-8 generation.	lipoteichoic acid	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	232-245
16428071-5	2006	Budesonide had a suppressive effect on both constitutive and LPS-induced IL-8 gene expression.	Budesonide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
16511915-0	2006	Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis.	Simvastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
16428068-12	2006	Moreover, NS-398 suppressed the anti-apoptotic activity of IL-8 and IL-1beta, but did not induce COX-2; therefore, the pro-apoptotic mechanism of the selective COX-2 inhibitor may be unrelated to COX-2 activity.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	10-16	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
16511915-3	2006	We investigated whether simvastatin could inhibit the expression of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha (TNF-alpha) in fibroblast-like synoviocytes (FLS) obtained from RA patients undergoing joint replacement therapy.	Simvastatin	24-35	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
16511915-6	2006	RESULTS: Real-time PCR analysis revealed that the levels of IL-6 and IL-8 mRNA expressed by FLS were reduced by simvastatin in a dose-dependent manner.	Simvastatin	112-123	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
16476030-5	2006	RESULTS: Following the dexamethasone treatment, the levels of TNF-alpha, IL-1-alpha, IL-6, and IL-8 were decreased significantly, and IL-1-alpha and IL-8 were detected at a level without a statistically significant difference from controls.	Dexamethasone	23-36	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
16511915-7	2006	Levels of IL-6 and IL-8 in FLS culture supernatants were decreased by simvastatin in a time-dependent and dose-dependent manner.	Simvastatin	70-81	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
16511915-9	2006	These effects of simvastatin on IL-6 and IL-8 production and cell proliferation were reversed in the presence of mevalonic acid or geranylgeranyl-pyrophosphate, but not with farnesyl-pyrophosphate.	Simvastatin	17-28	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
16511915-9	2006	These effects of simvastatin on IL-6 and IL-8 production and cell proliferation were reversed in the presence of mevalonic acid or geranylgeranyl-pyrophosphate, but not with farnesyl-pyrophosphate.	Mevalonic Acid	113-127	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
16511915-9	2006	These effects of simvastatin on IL-6 and IL-8 production and cell proliferation were reversed in the presence of mevalonic acid or geranylgeranyl-pyrophosphate, but not with farnesyl-pyrophosphate.	geranylgeranyl pyrophosphate	131-159	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
16511915-10	2006	CONCLUSION: Our results suggest that the beneficial effect of simvastatin in RA patients may involve inhibition of IL-6 and IL-8 production, as well as reduction of cell proliferation.	Simvastatin	62-73	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
16384711-6	2006	RESULTS: PMA and fMLP-induced neutrophil respiratory burst and chemotaxis were lower after 14 days of NAC intake but not after 2 h. In vitro incubation with NAC inhibited release of elastase (p &lt; 0.05), IL-8 (p &lt; 0.05), respiratory burst and NFkappaB activation at 10 mM but not at lower concentrations.	Acetylcysteine	102-105	C-X-C motif chemokine ligand 8	Homo sapiens	206-210
16465414-1	2006	We previously demonstrated the doxorubicin-induced expression of urokinase-type plasminogen activator (uPA), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha in human RC-K8 lymphoma cells and NCI-H69 small cell lung carcinoma cells in which reactive oxygen species might be involved.	Doxorubicin	31-42	C-X-C motif chemokine ligand 8	Homo sapiens	109-122
16465414-1	2006	We previously demonstrated the doxorubicin-induced expression of urokinase-type plasminogen activator (uPA), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha in human RC-K8 lymphoma cells and NCI-H69 small cell lung carcinoma cells in which reactive oxygen species might be involved.	Doxorubicin	31-42	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
16384711-6	2006	RESULTS: PMA and fMLP-induced neutrophil respiratory burst and chemotaxis were lower after 14 days of NAC intake but not after 2 h. In vitro incubation with NAC inhibited release of elastase (p &lt; 0.05), IL-8 (p &lt; 0.05), respiratory burst and NFkappaB activation at 10 mM but not at lower concentrations.	Acetylcysteine	157-160	C-X-C motif chemokine ligand 8	Homo sapiens	206-210
16476030-5	2006	RESULTS: Following the dexamethasone treatment, the levels of TNF-alpha, IL-1-alpha, IL-6, and IL-8 were decreased significantly, and IL-1-alpha and IL-8 were detected at a level without a statistically significant difference from controls.	Dexamethasone	23-36	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
16503719-7	2006	Atorvastatin significantly reduced the production of epithelial neutrophil-activating peptide-78, interleukin-6, interleukin-8, and monocyte chemotactic protein-1 (p&lt;0.001 to p&lt;0.05) in a concentration-dependent manner without affecting basal production of interleukin-10, fibroblast growth factor, and granulocyte colony stimulating factor.	Atorvastatin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	113-126
16397875-5	2006	The mean values of IL-1beta, IL-8, and IL-10 at T4 were lower in the HFOV group than in the PSV + VG group.	hfov	69-73	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
16300899-7	2006	Concomitantly, CRCHM elicited decrease in the catalytic adenylate cyclase (AC) activity (cAMP formation) in response to isoproterenol plus GTP or forskolin or NaF.	crchm	15-20	C-X-C motif chemokine ligand 8	Homo sapiens	159-162
16552354-6	2006	IL-8 secretions from ECs and PMNs were higher with 300 and 600 micromol/L than with 1000 micromol/L GLN, and this was consistent with the expression of the IL-8 receptor on PMNs.	Glutamine	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
16552354-6	2006	IL-8 secretions from ECs and PMNs were higher with 300 and 600 micromol/L than with 1000 micromol/L GLN, and this was consistent with the expression of the IL-8 receptor on PMNs.	Glutamine	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
16552354-11	2006	GLN administration at levels similar to or higher than physiological concentrations reduced IL-8 and adhesion molecule expression, and PMN transmigration was also decreased after stimulation with plasma or PDF from a surgical patient.	Glutamine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
16483201-1	2006	Rotationally resolved infrared spectra are reported for the binary complexes of HCN and LiF, LiCl, NaF, and NaCl, formed in helium nanodroplets.	Helium	124-130	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
16448181-3	2006	The inhibition of H2O2-induced IL-8 secretion from Caco-2 cells was observed by pretreatment for 2 h with PPPs, but not with phosvitin.	Hydrogen Peroxide	18-22	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
16197369-0	2006	Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells.	lysophosphatidic acid	30-51	C-X-C motif chemokine ligand 8	Homo sapiens	60-73
16197369-3	2006	We have recently demonstrated that LPA (lysophosphatidic acid) stimulated IL-8 production in HBEpCs via protein kinase C delta dependent signal transduction.	lysophosphatidic acid	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
16197369-3	2006	We have recently demonstrated that LPA (lysophosphatidic acid) stimulated IL-8 production in HBEpCs via protein kinase C delta dependent signal transduction.	lysophosphatidic acid	40-61	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
16197369-6	2006	Exposure of HBEpCs to LPA (1 microM) enhanced expression and secretion of IL-8 by 5-8-fold and stimulated threonine/tyrosine phosphorylation of ERK (extracellular-signal-regulated kinase), p38 MAPK and JNK (c-Jun N-terminal kinase).	lysophosphatidic acid	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
16197369-7	2006	The LPA-induced secretion of IL-8 was blocked by the p38 MAPK inhibitor SB203580, by p38 MAPK siRNA (small interfering RNA), and by the JNK inhibitor JNK(i) II, but not by the MEK (MAPK/ERK kinase) inhibitor, PD98059.	lysophosphatidic acid	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
16499573-10	2006	We also observed that throughout C. trachomatis persistence induced by doxycycline (Dox) treatment, IL-1beta, IL-6, IL-8 and TNF-alpha expression was reduced, whereas the synthesis of IL-10 and IL-12p70 remained unchanged but not sustained.	Doxycycline	84-87	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
16451045-3	2006	We investigated the effects of NaF, NaCl, NaBr, and NaI on the molecular organization of H2O by a calorimetric methodology developed by us earlier.	Water	89-92	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
16197369-7	2006	The LPA-induced secretion of IL-8 was blocked by the p38 MAPK inhibitor SB203580, by p38 MAPK siRNA (small interfering RNA), and by the JNK inhibitor JNK(i) II, but not by the MEK (MAPK/ERK kinase) inhibitor, PD98059.	SB 203580	72-80	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
16197369-7	2006	The LPA-induced secretion of IL-8 was blocked by the p38 MAPK inhibitor SB203580, by p38 MAPK siRNA (small interfering RNA), and by the JNK inhibitor JNK(i) II, but not by the MEK (MAPK/ERK kinase) inhibitor, PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	209-216	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
16197369-9	2006	Furthermore, SB203580 attenuated LPA-dependent phosphorylation of IkappaB (inhibitory kappaB), NF-kappaB and phospho-p38 translocation to the nucleus, NF-kappaB transcription and IL-8 promoter-mediated luciferase reporter activity, without affecting the JNK pathway and AP-1 transcription.	SB 203580	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
16197369-9	2006	Furthermore, SB203580 attenuated LPA-dependent phosphorylation of IkappaB (inhibitory kappaB), NF-kappaB and phospho-p38 translocation to the nucleus, NF-kappaB transcription and IL-8 promoter-mediated luciferase reporter activity, without affecting the JNK pathway and AP-1 transcription.	lysophosphatidic acid	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
16197369-10	2006	Similarly, JNK(i) II only blocked LPA-mediated phosphorylation of JNK and c-Jun, AP-1 transcription and IL-8 promoter-mediated luciferase reporter activity, without blocking p38 MAPK-dependent NF-kappaB transcription.	lysophosphatidic acid	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
16197369-11	2006	Additionally, siRNA for LPA(1-3) receptors partially blocked LPA-induced IL-8 production and activation of MAPKs.	lysophosphatidic acid	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
16197369-12	2006	The LPA1 and LPA3 receptors, as compared with LPA2, were most efficient in transducing LPA-mediated IL-8 production.	lysophosphatidic acid	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
16197369-13	2006	These results show an independent role for p38 MAPK and JNK in LPA-induced IL-8 expression and secretion via NF-kappaB and AP-1 transcription respectively in HBEpCs.	lysophosphatidic acid	63-66	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
16300899-7	2006	Concomitantly, CRCHM elicited decrease in the catalytic adenylate cyclase (AC) activity (cAMP formation) in response to isoproterenol plus GTP or forskolin or NaF.	Cyclic AMP	89-93	C-X-C motif chemokine ligand 8	Homo sapiens	159-162
16269456-14	2006	Adrenal-secreted IL-8 is one point of convergence between the adrenal gland and the immune system and may have relevance in physiological and pathophysiological conditions associated with increased levels of aldosterone secretagogues and the immune system.	Aldosterone	208-219	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
16447232-8	2006	Finally, CQ-resistant CEM cells displayed a markedly reduced capacity to release proinflammatory cytokines (tumor necrosis factor alpha) and chemokines (interleukin-8).	Chloroquine	9-11	C-X-C motif chemokine ligand 8	Homo sapiens	153-166
16265667-6	2006	Furthermore, our studies on the intracellular signaling pathways reveal that poly(I:C) stimulation activates IkappaB kinase (IKK), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in CRT-MG. Pharmacological inhibitors of nuclear factor-kappaB (NF-kappaB), JNK, ERK, glycogen synthase kinase-3beta (GSK-3beta), and dsRNA-activated protein kinase (PKR) inhibit the expression of IL-8 and IP-10 in astrocytes, indicating that the activation of these signaling molecules is required for the TLR3-mediated chemokine gene induction.	Poly I-C	77-86	C-X-C motif chemokine ligand 8	Homo sapiens	407-411
16352735-0	2006	Anti-inflammatory effects of moxifloxacin on IL-8, IL-1beta and TNF-alpha secretion and NFkappaB and MAP-kinase activation in human monocytes stimulated with Aspergillus fumigatus.	Moxifloxacin	29-41	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
16373365-6	2006	Results from reverse transcription-PCR and flow cytometry analysis of HUTEC indicate that the interaction with Daudi cells induce an increased expression of IL-6 and IL-8 mRNA and cell-surface expression of intercellular adhesion molecule-1, all of which were prevented by sodium salicylate, an inhibitor of NF-kappaB activation.	Sodium Salicylate	273-290	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
16455619-5	2006	Prior treatment with PGE(2) (1 microM) produced 86 and 80% decreases in GM-CSF and IL-8 release, respectively.	Dinoprostone	21-27	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
16384605-9	2006	Magnesium sulfate dose dependently inhibited the endotoxin-stimulated IL-8 production in both decidual and amniotic cells.	Magnesium Sulfate	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
16384605-11	2006	In conclusion, magnesium sulfate differentially suppresses endotoxin-stimulated IL-8 production in amniotic and decidual cells in vitro.	Magnesium Sulfate	15-32	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
16467702-7	2006	RESULTS: There were statistically significant improvements in SNOT-20 score, nasal endoscopy, saccharine transit time, and IL-8 levels in lavage fluid (P&lt;.05) in the macrolide group.	Macrolides	169-178	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
16455619-6	2006	Similarly, the cAMP analogue, 8-bromo-cAMP (8Br-cAMP) and the phosphodiesterase-4 (PDE(4)) inhibitor, rolipram, also repressed GM-CSF and IL-8 release.	Cyclic AMP	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
16455619-6	2006	Similarly, the cAMP analogue, 8-bromo-cAMP (8Br-cAMP) and the phosphodiesterase-4 (PDE(4)) inhibitor, rolipram, also repressed GM-CSF and IL-8 release.	8-Bromo Cyclic Adenosine Monophosphate	30-42	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
16249194-11	2006	In the in vitro studies, the average value for cell-associated IL-6 and IL-8 was higher in CKD (155+/-95 pg/ml monocytes for IL-6 and 722+/-921 pg/ml monocytes for IL-8) vs HS (137+/-87 pg/ml monocytes and 186+/-125 pg/ml monocytes) (P&lt;0.01) and was not affected by simvastatin alone.	Simvastatin	269-280	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
16455619-6	2006	Similarly, the cAMP analogue, 8-bromo-cAMP (8Br-cAMP) and the phosphodiesterase-4 (PDE(4)) inhibitor, rolipram, also repressed GM-CSF and IL-8 release.	8-Bromo Cyclic Adenosine Monophosphate	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
16455619-6	2006	Similarly, the cAMP analogue, 8-bromo-cAMP (8Br-cAMP) and the phosphodiesterase-4 (PDE(4)) inhibitor, rolipram, also repressed GM-CSF and IL-8 release.	Rolipram	102-110	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
16278684-4	2006	Treatment with SB-216763 increased expression of cyclooxygenase-2 (COX-2) and IL-8, which are downstream targets of ERK1/2 activation; this induction was abolished by MEK/ERK inhibition, suggesting GSK-3 inhibition induced COX-2 and IL-8 through ERK1/2 activation.	SB 216763	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
16393986-8	2006	In addition, PTX-B inhibited the secretion of IL-6-induced, AP-1-dependent genes, including urokinase-type plasminogen activator, CXCL8/IL-8, and CCL2/monocyte chemotactic protein-1.	pumiliotoxin B	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	130-135
16393986-8	2006	In addition, PTX-B inhibited the secretion of IL-6-induced, AP-1-dependent genes, including urokinase-type plasminogen activator, CXCL8/IL-8, and CCL2/monocyte chemotactic protein-1.	pumiliotoxin B	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
16183151-27	2006	Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes.	Homocysteine	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	89-102
16388589-4	2006	Their stabilities depend significantly upon the presence of salt: strongly for NaCl but less so for NaF, demonstrating specific interactions with chloride ions.	Salts	60-64	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
16388589-4	2006	Their stabilities depend significantly upon the presence of salt: strongly for NaCl but less so for NaF, demonstrating specific interactions with chloride ions.	Chlorides	146-154	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
16388589-7	2006	A comparison of the effects of NaCl/KCl with NaF showed that homeodomain binding results in a release not only of cations from the DNA phosphates but also of chloride ions specifically associated with the proteins.	Sodium Chloride	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
16388589-7	2006	A comparison of the effects of NaCl/KCl with NaF showed that homeodomain binding results in a release not only of cations from the DNA phosphates but also of chloride ions specifically associated with the proteins.	Phosphates	135-145	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
16388589-7	2006	A comparison of the effects of NaCl/KCl with NaF showed that homeodomain binding results in a release not only of cations from the DNA phosphates but also of chloride ions specifically associated with the proteins.	Chlorides	158-166	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
16394009-0	2006	Activation of TLR-9 induces IL-8 secretion through peroxynitrite signaling in human neutrophils.	Peroxynitrous Acid	51-64	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
16394009-3	2006	Recent studies indicate that peroxynitrite (ONOO-) may function as an intracellular signal for the production of IL-8, one of the key regulators of leukocyte trafficking in inflammation.	Peroxynitrous Acid	29-42	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
16394009-3	2006	Recent studies indicate that peroxynitrite (ONOO-) may function as an intracellular signal for the production of IL-8, one of the key regulators of leukocyte trafficking in inflammation.	oxido nitrite	44-49	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
16394009-8	2006	CpG-DNA-induced IL-8 mRNA expression and release was also blocked by the NO synthase inhibitor Nomega-nitro-L-arginine methyl ester.	NG-Nitroarginine Methyl Ester	95-131	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
16394009-11	2006	These results identify ONOO- -dependent activation of NF-kappaB and c-Fos as an important mechanism that mediates PMN responses, including IL-8 gene expression and release, to bacterial DNA and unmethylated CpG motifs in particular.	onoo	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
16278684-4	2006	Treatment with SB-216763 increased expression of cyclooxygenase-2 (COX-2) and IL-8, which are downstream targets of ERK1/2 activation; this induction was abolished by MEK/ERK inhibition, suggesting GSK-3 inhibition induced COX-2 and IL-8 through ERK1/2 activation.	SB 216763	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	233-237
16278684-5	2006	The transcriptional induction of COX-2 and IL-8 by GSK-3 inhibition was further demonstrated by the increased COX-2 and IL-8 promoter activity after SB-216763 treatment or transfection with GSK-3alpha or GSK-3beta siRNA.	SB 216763	149-158	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
16278684-5	2006	The transcriptional induction of COX-2 and IL-8 by GSK-3 inhibition was further demonstrated by the increased COX-2 and IL-8 promoter activity after SB-216763 treatment or transfection with GSK-3alpha or GSK-3beta siRNA.	SB 216763	149-158	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
16364007-8	2006	DEX treatment reduced IL-8 levels in control and LPS-treated cultures by 70-90%.	Dextromethorphan	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
16671497-6	2006	RESULTS: HUVECs cultured at glucose concentrations of 300 and 400 mg/dL produced more (p &lt; 0.01) IL-8 than control cells (200 mg/dL).	Glucose	28-35	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
16671497-7	2006	HUVECs cultured at glucose concentrations of 300 and 400 mg/dL also produced more (p &lt; 0.01) IL-8 than those cultured in the absence of LPS.	Glucose	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
16085674-0	2006	Macrolide antibiotics modulate ERK phosphorylation and IL-8 and GM-CSF production by human bronchial epithelial cells.	macrolide antibiotics	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
16085674-4	2006	CAM decreased IL-8 over the first 6 h and then significantly increased interleukin (IL)-8 at 12-72 h after exposure (P &lt; 0.0001).	Clarithromycin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
16085674-4	2006	CAM decreased IL-8 over the first 6 h and then significantly increased interleukin (IL)-8 at 12-72 h after exposure (P &lt; 0.0001).	Clarithromycin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	71-89
16085674-5	2006	AZM also increased IL-8 at 24 and 48 h, and CAM increased granulocyte-macrophage colony-stimulating factor at 48 h. In the presence of LPS, both CAM and AZM dose-dependently increased IL-8 secretion over 24 h, but after 5 days of exposure to 10 microg/ml CAM there is suppression of IL-8 (P &lt; 0.001).	Azithromycin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
16085674-5	2006	AZM also increased IL-8 at 24 and 48 h, and CAM increased granulocyte-macrophage colony-stimulating factor at 48 h. In the presence of LPS, both CAM and AZM dose-dependently increased IL-8 secretion over 24 h, but after 5 days of exposure to 10 microg/ml CAM there is suppression of IL-8 (P &lt; 0.001).	Clarithromycin	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
16085674-5	2006	AZM also increased IL-8 at 24 and 48 h, and CAM increased granulocyte-macrophage colony-stimulating factor at 48 h. In the presence of LPS, both CAM and AZM dose-dependently increased IL-8 secretion over 24 h, but after 5 days of exposure to 10 microg/ml CAM there is suppression of IL-8 (P &lt; 0.001).	Clarithromycin	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
16085674-5	2006	AZM also increased IL-8 at 24 and 48 h, and CAM increased granulocyte-macrophage colony-stimulating factor at 48 h. In the presence of LPS, both CAM and AZM dose-dependently increased IL-8 secretion over 24 h, but after 5 days of exposure to 10 microg/ml CAM there is suppression of IL-8 (P &lt; 0.001).	Azithromycin	153-156	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
16085674-5	2006	AZM also increased IL-8 at 24 and 48 h, and CAM increased granulocyte-macrophage colony-stimulating factor at 48 h. In the presence of LPS, both CAM and AZM dose-dependently increased IL-8 secretion over 24 h, but after 5 days of exposure to 10 microg/ml CAM there is suppression of IL-8 (P &lt; 0.001).	Azithromycin	153-156	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
16085674-5	2006	AZM also increased IL-8 at 24 and 48 h, and CAM increased granulocyte-macrophage colony-stimulating factor at 48 h. In the presence of LPS, both CAM and AZM dose-dependently increased IL-8 secretion over 24 h, but after 5 days of exposure to 10 microg/ml CAM there is suppression of IL-8 (P &lt; 0.001).	Azithromycin	153-156	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
16085674-5	2006	AZM also increased IL-8 at 24 and 48 h, and CAM increased granulocyte-macrophage colony-stimulating factor at 48 h. In the presence of LPS, both CAM and AZM dose-dependently increased IL-8 secretion over 24 h, but after 5 days of exposure to 10 microg/ml CAM there is suppression of IL-8 (P &lt; 0.001).	Clarithromycin	145-148	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
16085674-5	2006	AZM also increased IL-8 at 24 and 48 h, and CAM increased granulocyte-macrophage colony-stimulating factor at 48 h. In the presence of LPS, both CAM and AZM dose-dependently increased IL-8 secretion over 24 h, but after 5 days of exposure to 10 microg/ml CAM there is suppression of IL-8 (P &lt; 0.001).	Clarithromycin	145-148	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
16085674-5	2006	AZM also increased IL-8 at 24 and 48 h, and CAM increased granulocyte-macrophage colony-stimulating factor at 48 h. In the presence of LPS, both CAM and AZM dose-dependently increased IL-8 secretion over 24 h, but after 5 days of exposure to 10 microg/ml CAM there is suppression of IL-8 (P &lt; 0.001).	Clarithromycin	145-148	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
16085674-6	2006	PD-98059, an inhibitor of MAP kinase/ERK kinase, inhibited CAM-induced IL-8 (P &lt; 0.0001) and GM-CSF (P &lt; 0.01) release.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
16085674-7	2006	The p38 MAP kinase inhibitor SB-203580 increased CAM-induced IL-8 release (P &lt; 0.001), and the c-jun NH2-terminal kinase inhibitor SP-600125 had no effect on IL-8.	SB 203580	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
16085674-7	2006	The p38 MAP kinase inhibitor SB-203580 increased CAM-induced IL-8 release (P &lt; 0.001), and the c-jun NH2-terminal kinase inhibitor SP-600125 had no effect on IL-8.	Clarithromycin	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
16085674-11	2006	The p38 MAP kinase inhibitor, SB-203580 increased ERK phosphorylation and IL-8 secretion.	SB 203580	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
16803639-6	2006	RGD-targeted adenovirus delivered the dnIkappaB via alphavbeta3 to become functionally expressed, leading to complete abolishment of TNF-alpha-induced up-regulation of E-selectin, ICAM-1, VCAM-1, IL-6, IL-8, VEGF-A and Tie-2.	dnikappab	38-47	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
17002793-9	2006	These cytokines have previously been shown to independently regulate the frequency (IFN-gamma) and amplitude (IL-8) of the oscillations of key metabolites in neutrophils, including nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) and superoxide ion.	NAD	181-214	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
17002793-9	2006	These cytokines have previously been shown to independently regulate the frequency (IFN-gamma) and amplitude (IL-8) of the oscillations of key metabolites in neutrophils, including nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) and superoxide ion.	Phosphates	216-225	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
17002793-9	2006	These cytokines have previously been shown to independently regulate the frequency (IFN-gamma) and amplitude (IL-8) of the oscillations of key metabolites in neutrophils, including nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) and superoxide ion.	Superoxides	241-251	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
17469513-11	2006	ATP content was reduced with rising concentrations of NaF: by 74.6% at 20 tmol/L; by 75.5% at 100 micromol/L; by 90.8% at 200 imol/L; and by 99.9% at 10(5) micromol/L.	Adenosine Triphosphate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
16924333-5	2006	Mouse lymphoma and human fibroblast cells were exposed to sodium fluoride (NaF) at final concentration ranging from 7 to 100 microg/mL for 3 h at 37 degrees C. The results pointed out that NaF in all tested concentrations did not contribute to DNA damage as depicted by the mean tail moment and tail intensity for both cellular types assessed.	Sodium Fluoride	58-73	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
17100619-9	2006	In human monocytic cells, both MDP and DMPs exhibited definite activities; marked synergistic interleukin (IL)-8 secretion was induced by DMPs and MDP in combination with synthetic TLR agonists, and suppression of the mRNA expressions of NOD1 and NOD2, respectively, by RNA interference specifically inhibited synergistic IL-8 secretion.	Unithiol	39-43	C-X-C motif chemokine ligand 8	Homo sapiens	94-112
16253565-4	2006	Incubation with poly(I:C) significantly enhanced the secretion of RANTES and IL-8.	poly	16-20	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
16253565-6	2006	The JNK inhibitor SP600125 and the PI3-kinase inhibitor LY294002 significantly blocked the poly(I:C)-induced release of RANTES and IL-8, whereas the p38 MAP kinase inhibitor SB203580 suppressed poly(I:C)-induced secretion of IL-8, but not RANTES.	pyrazolanthrone	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
16253565-6	2006	The JNK inhibitor SP600125 and the PI3-kinase inhibitor LY294002 significantly blocked the poly(I:C)-induced release of RANTES and IL-8, whereas the p38 MAP kinase inhibitor SB203580 suppressed poly(I:C)-induced secretion of IL-8, but not RANTES.	pyrazolanthrone	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	225-229
16253565-6	2006	The JNK inhibitor SP600125 and the PI3-kinase inhibitor LY294002 significantly blocked the poly(I:C)-induced release of RANTES and IL-8, whereas the p38 MAP kinase inhibitor SB203580 suppressed poly(I:C)-induced secretion of IL-8, but not RANTES.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
16253565-6	2006	The JNK inhibitor SP600125 and the PI3-kinase inhibitor LY294002 significantly blocked the poly(I:C)-induced release of RANTES and IL-8, whereas the p38 MAP kinase inhibitor SB203580 suppressed poly(I:C)-induced secretion of IL-8, but not RANTES.	SB 203580	174-182	C-X-C motif chemokine ligand 8	Homo sapiens	225-229
16963197-7	2006	Cytologic evaluation was performed on Papanicolaou-stained cytospin preparations of NAF.	papanicolaou	38-50	C-X-C motif chemokine ligand 8	Homo sapiens	84-87
17945891-7	2006	Our simulation results identify TGF-beta, IL-8 and IL-13 as the intervention points which are consistent with known clinical results to prevent DHF from occurring.	dhf	144-147	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
17100619-9	2006	In human monocytic cells, both MDP and DMPs exhibited definite activities; marked synergistic interleukin (IL)-8 secretion was induced by DMPs and MDP in combination with synthetic TLR agonists, and suppression of the mRNA expressions of NOD1 and NOD2, respectively, by RNA interference specifically inhibited synergistic IL-8 secretion.	Unithiol	39-43	C-X-C motif chemokine ligand 8	Homo sapiens	322-326
17100619-9	2006	In human monocytic cells, both MDP and DMPs exhibited definite activities; marked synergistic interleukin (IL)-8 secretion was induced by DMPs and MDP in combination with synthetic TLR agonists, and suppression of the mRNA expressions of NOD1 and NOD2, respectively, by RNA interference specifically inhibited synergistic IL-8 secretion.	Unithiol	138-142	C-X-C motif chemokine ligand 8	Homo sapiens	94-112
16433036-3	2006	Centrifugal force enhanced the cytotoxicity of sodium fluoride (NaF), but not that of redox compounds (hydrogen peroxide, sodium ascorbate, gallic acid) or chemotherapeutic agents (daunorubicin, doxorubicin, idarubicin, mitoxantrone, peplomycin, 5-FU).	Sodium Fluoride	47-62	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
16387930-1	2006	Clarithromycin (CM) has been found to inhibit the production of the intercellular adhesion molecule (ICAM)-1 and the secretion of interleukin (IL)-6 and IL-8, which may have beneficial effects on the pathophysiological changes related to rhinovirus (RV) infection.	Clarithromycin	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
16387930-1	2006	Clarithromycin (CM) has been found to inhibit the production of the intercellular adhesion molecule (ICAM)-1 and the secretion of interleukin (IL)-6 and IL-8, which may have beneficial effects on the pathophysiological changes related to rhinovirus (RV) infection.	Clarithromycin	16-18	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
17974146-8	2006	The elevated IL-8 level in PBMCs of CRF reflect the imbalance of Thl/Th2 ratio and subsequent impairment of cellular immunity in those patients.	Orlistat	65-68	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
17974147-2	2006	Chronic elevated glucose level in DM increases monocyte adhesion to aortic endothelial cells (ECs) which is mediated primarily through induction of interleukin-8 (IL-8).	Glucose	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	148-161
17974147-2	2006	Chronic elevated glucose level in DM increases monocyte adhesion to aortic endothelial cells (ECs) which is mediated primarily through induction of interleukin-8 (IL-8).	Glucose	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
16423036-3	2006	Stimulation of HCECs with the TLR3 agonist poly(I:C) induced the activation of nuclear factor (NF)-kappaB and production of the proinflammatory cytokine interleukin (IL)-6 and the chemokine IL-8.	Poly I	43-49	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
16423036-3	2006	Stimulation of HCECs with the TLR3 agonist poly(I:C) induced the activation of nuclear factor (NF)-kappaB and production of the proinflammatory cytokine interleukin (IL)-6 and the chemokine IL-8.	Carbon	50-52	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
16491014-8	2006	Ro-31-8220, a PKC inhibitor, and PD98059, a mitogen-activated protein/ERK kinase inhibitor, suppressed the histamine-induced ERK activation and the production of granulocyte macrophage colony-stimulating factor and IL-8.	Ro 31-8220	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
16491014-0	2006	Histamine H1 receptor-stimulated interleukin 8 and granulocyte macrophage colony-stimulating factor production by bronchial epithelial cells requires extracellular signal-regulated kinase signaling via protein kinase C. BACKGROUND: Histamine stimulates the release of several cytokines, such as interleukin (IL)-8 and granulocyte macrophage colony-stimulating factor, from bronchial epithelial cells.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	295-313
16491014-8	2006	Ro-31-8220, a PKC inhibitor, and PD98059, a mitogen-activated protein/ERK kinase inhibitor, suppressed the histamine-induced ERK activation and the production of granulocyte macrophage colony-stimulating factor and IL-8.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	33-40	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
16491014-8	2006	Ro-31-8220, a PKC inhibitor, and PD98059, a mitogen-activated protein/ERK kinase inhibitor, suppressed the histamine-induced ERK activation and the production of granulocyte macrophage colony-stimulating factor and IL-8.	Histamine	107-116	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
16491014-11	2006	Histamine also augmented the IL-8 production caused by IL-4 or tumor necrosis factor-alpha.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
16741367-7	2006	RESULTS: Desloratadine and loratadine inhibited the constitutive and IFN-gamma-induced release of CCL5, CXCL8 and CXCL10 from keratinocytes, while the low release of CCL17 remained unchanged.	desloratadine	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	104-109
16697690-6	2006	It was also found that PD98059, a mitogen-activated protein kinase (MAPK) pathway inhibitor and U0126, an inhibitor of extracellular signal-regulated kinase (ERK) blocks thrombin-induced phosphorylation of ERK1/2 and IL-8 secretion, indicating the involvement of MAPK/ERK signaling pathway in thrombin-induced IL-8 secretion.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
16697690-6	2006	It was also found that PD98059, a mitogen-activated protein kinase (MAPK) pathway inhibitor and U0126, an inhibitor of extracellular signal-regulated kinase (ERK) blocks thrombin-induced phosphorylation of ERK1/2 and IL-8 secretion, indicating the involvement of MAPK/ERK signaling pathway in thrombin-induced IL-8 secretion.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	310-314
16697690-6	2006	It was also found that PD98059, a mitogen-activated protein kinase (MAPK) pathway inhibitor and U0126, an inhibitor of extracellular signal-regulated kinase (ERK) blocks thrombin-induced phosphorylation of ERK1/2 and IL-8 secretion, indicating the involvement of MAPK/ERK signaling pathway in thrombin-induced IL-8 secretion.	U 0126	96-101	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
16697690-6	2006	It was also found that PD98059, a mitogen-activated protein kinase (MAPK) pathway inhibitor and U0126, an inhibitor of extracellular signal-regulated kinase (ERK) blocks thrombin-induced phosphorylation of ERK1/2 and IL-8 secretion, indicating the involvement of MAPK/ERK signaling pathway in thrombin-induced IL-8 secretion.	U 0126	96-101	C-X-C motif chemokine ligand 8	Homo sapiens	310-314
16697690-7	2006	p38 MAPK pathway appears also being involved as SB203580, a selective inhibitor of p38 MAPK inhibit phosphorylation of p38 MAPK and thrombin-induced IL-8 secretion.	SB 203580	48-56	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
16741367-7	2006	RESULTS: Desloratadine and loratadine inhibited the constitutive and IFN-gamma-induced release of CCL5, CXCL8 and CXCL10 from keratinocytes, while the low release of CCL17 remained unchanged.	Loratadine	12-22	C-X-C motif chemokine ligand 8	Homo sapiens	104-109
16940740-0	2006	Prostaglandin D2 induces IL-8 and GM-CSF by bronchial epithelial cells in a CRTH2-independent pathway.	Prostaglandin D2	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
16772726-1	2006	BACKGROUND: In our previous study, oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs) significantly prolonged eosinophil survival without inducing active release of eosinophil-derived neurotoxin or interleukin 8.	Oligodeoxyribonucleotides	35-56	C-X-C motif chemokine ligand 8	Homo sapiens	215-228
17131711-13	2006	The fluoride uptake seen in the cycling model correlated with a standard FDA EFU procedure for the NaF dentifrices.	Fluorides	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
16897233-0	2006	Effects of sivelestat, a new elastase inhibitor, on IL-8 and MCP-1 production from stimulated human alveolar epithelial type II cells.	sivelestat	11-21	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
17131712-12	2006	A re-hardening study, in which a series of the new toothpaste-base formulations containing increasing concentrations of NaF were evaluated, showed a clear fluoride dose response.	Fluorides	155-163	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
17131711-8	2006	SMH for a 1450 ppm NaF test dentifrice was greater than for Elmex Sensitive (1450 ppm amine F) and placebo at 10 days, while both products were greater than the placebo at 20 days.	N-(2-Ethoxyethyl)-N-{(2s)-2-Hydroxy-3-[(2r)-6-Hydroxy-4-Oxo-3,4-Dihydro-1'h-Spiro[chromene-2,3'-Piperidin]-1'-Yl]propyl}-2,6-Dimethylbenzenesulfonamide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
17131711-10	2006	The fluoride uptake seen in the cycling model correlated for the NaF dentifrices with a standard EFU procedure.	Fluorides	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	20-45	C-X-C motif chemokine ligand 8	Homo sapiens	147-160
16332510-6	2006	Results showed that nicotine suppressed the LPS induced production of IL-6 and IL-8 in both cell lines.	Nicotine	20-28	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
16365062-0	2006	Soy isoflavones alter expression of genes associated with cancer progression, including interleukin-8, in androgen-independent PC-3 human prostate cancer cells.	Isoflavones	4-15	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	20-45	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	147-160
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
16490927-8	2006	In addition, both Go6976 and Rottlerin inhibited the up-regulation of CD93 expression induced by PMA and IL-8 or IFN-gamma production in the respective cell-lines.	Go 6976	18-24	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
16490927-8	2006	In addition, both Go6976 and Rottlerin inhibited the up-regulation of CD93 expression induced by PMA and IL-8 or IFN-gamma production in the respective cell-lines.	rottlerin	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
16391493-0	2006	Effect of berberine on interleukin 8 and monocyte chemotactic protein 1 expression in a human retinal pigment epithelial cell line.	Berberine	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	23-36
16391493-1	2006	PURPOSE: The aims of this study were to examine the effects of berberine, an alkaloid isolated from some medicinal herbs, on interleukin 8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) expression in a human retinal pigment epithelial cell line (ARPE-19) stimulated with interleukin 1beta (IL-1beta) or tumor necrosis factor alpha (TNF-alpha).	Berberine	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	125-138
16391493-1	2006	PURPOSE: The aims of this study were to examine the effects of berberine, an alkaloid isolated from some medicinal herbs, on interleukin 8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) expression in a human retinal pigment epithelial cell line (ARPE-19) stimulated with interleukin 1beta (IL-1beta) or tumor necrosis factor alpha (TNF-alpha).	Berberine	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
16391493-7	2006	CONCLUSION: These findings indicate that berberine dose-dependently inhibited the expression of IL-8 and MCP-1 induced by IL-1beta or TNF-alpha.	Berberine	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
16497101-10	2006	Chemokine pathway (IL-8) and TNF-alpha activity seem to be modulated by Goeckerman"s therapy (polycyclic aromatic hydrocarbons).	Polycyclic Aromatic Hydrocarbons	94-126	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
16129464-4	2006	Two hirsutinolides were studied for their NF-kappaB DNA binding activity in HaCaT cells (a human cell line similar to keratinocytes) and for their inhibition on IL-8 production in HeLa cells.	hirsutinolides	4-18	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
16084120-6	2006	GM-CSF and IL-8 release by stimulated HBECs was also downregulated by ciclesonide (p &lt; 0.05).	ciclesonide	70-81	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
16543969-5	2006	17beta-dihydroequilenin and 17beta-estradiol at a concentration of 1 microM reduced IL-1alpha-induced up regulation of IL-6, IL-8 and MCP-1 close to control levels.	17-dihydroequilenin	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
16543969-5	2006	17beta-dihydroequilenin and 17beta-estradiol at a concentration of 1 microM reduced IL-1alpha-induced up regulation of IL-6, IL-8 and MCP-1 close to control levels.	Estradiol	28-44	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
16554988-4	2006	CONCLUSION: Sivelestat sodium suppressed the production of PMN elastase and IL-8, resulting in improved respiratory function in patients with ALI caused by CPB.	Sivelestat sodium	12-29	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
16543969-8	2006	The effect of 17beta-dihydroequilenin on IL-1alpha-induced production of IL-6, IL-8 and MCP-1 was reversed by the estrogen receptor antagonist ICI 182,780.	17-dihydroequilenin	14-37	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
16303327-5	2005	Subsequently, various concentrations of cis-9,trans-11-CLA vs. linoleic acid (LA, cis-9,cis-12-octadecadienoic acid) were tested for the effect on proliferative response and release of the pro-inflammatory cytokine IL-8 in stimulated BEAS-2B.	Linoleic Acid	82-115	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
16646301-7	2006	In response to cigarette smoke lung epithelium may release TNF-alpha, TGF-beta, IL-1beta, GM-CSF, IL-8 reactive oxygen species (ROS).	Reactive Oxygen Species	103-126	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
16303327-6	2005	Addition of cis-9,trans-11-CLA attenuated cell growth and significantly reduced IL-8 production at mRNA and protein levels.	cis-9, trans-11-conjugated linoleic acid	12-30	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
16303327-8	2005	It was demonstrated that the inhibitory effect of cis-9,trans-11-CLA on IL-8 production is mediated through activation of the nuclear receptor PPARgamma, since blocking the receptor with a selective antagonist (GW9662) restored the stimulus-induced enhancement in IL-8 mRNA expression and protein secretion.	cis-9	50-55	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
16303327-8	2005	It was demonstrated that the inhibitory effect of cis-9,trans-11-CLA on IL-8 production is mediated through activation of the nuclear receptor PPARgamma, since blocking the receptor with a selective antagonist (GW9662) restored the stimulus-induced enhancement in IL-8 mRNA expression and protein secretion.	cis-9	50-55	C-X-C motif chemokine ligand 8	Homo sapiens	264-268
16303327-8	2005	It was demonstrated that the inhibitory effect of cis-9,trans-11-CLA on IL-8 production is mediated through activation of the nuclear receptor PPARgamma, since blocking the receptor with a selective antagonist (GW9662) restored the stimulus-induced enhancement in IL-8 mRNA expression and protein secretion.	trans-11-cla	56-68	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
16303327-8	2005	It was demonstrated that the inhibitory effect of cis-9,trans-11-CLA on IL-8 production is mediated through activation of the nuclear receptor PPARgamma, since blocking the receptor with a selective antagonist (GW9662) restored the stimulus-induced enhancement in IL-8 mRNA expression and protein secretion.	trans-11-cla	56-68	C-X-C motif chemokine ligand 8	Homo sapiens	264-268
16303327-8	2005	It was demonstrated that the inhibitory effect of cis-9,trans-11-CLA on IL-8 production is mediated through activation of the nuclear receptor PPARgamma, since blocking the receptor with a selective antagonist (GW9662) restored the stimulus-induced enhancement in IL-8 mRNA expression and protein secretion.	2-chloro-5-nitrobenzanilide	211-217	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
16303327-8	2005	It was demonstrated that the inhibitory effect of cis-9,trans-11-CLA on IL-8 production is mediated through activation of the nuclear receptor PPARgamma, since blocking the receptor with a selective antagonist (GW9662) restored the stimulus-induced enhancement in IL-8 mRNA expression and protein secretion.	2-chloro-5-nitrobenzanilide	211-217	C-X-C motif chemokine ligand 8	Homo sapiens	264-268
16343928-3	2005	Increase of intracellular Ca(2+) resulted in inducing IL-8 gene expression and protein secretion, and addition of EGTA or BAPTA/AM before Ca(2+) stimulation inhibited the induction of IL-8 production.	Egtazic Acid	114-118	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
16269654-7	2005	The inhibitory effect of adiponectin on TNF-alpha-induced IL-8 synthesis was inhibited by pretreatment with Rp-cAMP, a PKA inhibitor.	Cyclic AMP	111-115	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
16269654-10	2005	The inhibitory effect of adiponectin on TNF-alpha-induced IL-8 synthesis was abrogated in part by pretreatment with the PI3 kinase inhibitor LY294002 or by Akt siRNA transfection, suggesting that Akt activation might inhibit IL-8 synthesis induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
16269654-10	2005	The inhibitory effect of adiponectin on TNF-alpha-induced IL-8 synthesis was abrogated in part by pretreatment with the PI3 kinase inhibitor LY294002 or by Akt siRNA transfection, suggesting that Akt activation might inhibit IL-8 synthesis induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	C-X-C motif chemokine ligand 8	Homo sapiens	225-229
16343928-3	2005	Increase of intracellular Ca(2+) resulted in inducing IL-8 gene expression and protein secretion, and addition of EGTA or BAPTA/AM before Ca(2+) stimulation inhibited the induction of IL-8 production.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	122-127	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
16343928-5	2005	Pretreatment of MAPK inhibitors (PD98059 and SB203580) markedly blocked Ca(2+)-induced IL-8 production from cells, and anti-inflammatory drugs, such as dexamethasone and cyclosporin A, partially inhibited the activation of ERK1/2.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	33-40	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
16343928-5	2005	Pretreatment of MAPK inhibitors (PD98059 and SB203580) markedly blocked Ca(2+)-induced IL-8 production from cells, and anti-inflammatory drugs, such as dexamethasone and cyclosporin A, partially inhibited the activation of ERK1/2.	SB 203580	45-53	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
16109883-6	2005	Moreover, UDP-glc increased secretion of the potent neutrophil chemoattractant CXCL8/IL-8 in A549 and BEAS-2B cells in a pertussis toxin-sensitive manner.	Uridine Diphosphate Glucose	10-17	C-X-C motif chemokine ligand 8	Homo sapiens	79-84
16266385-6	2005	A single dose of nasal budesonide caused a decrease in symptoms (P &lt; 0.05) and nasal eosinophils (P &lt; 0.05) with selective abrogation of IL-5 and IL-13 responses (P &lt; 0.05), but a lack of effect on levels of eotaxin, RANTES, IL-8 and MCP-1.	Budesonide	23-33	C-X-C motif chemokine ligand 8	Homo sapiens	234-238
16109883-6	2005	Moreover, UDP-glc increased secretion of the potent neutrophil chemoattractant CXCL8/IL-8 in A549 and BEAS-2B cells in a pertussis toxin-sensitive manner.	Uridine Diphosphate Glucose	10-17	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
16109883-7	2005	Moreover, reverse transcription and quantitative polymerase chain reaction revealed that UDP-glc modulated mRNA levels of IL-8/CXCL8.	Uridine Diphosphate Glucose	89-96	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
16109883-7	2005	Moreover, reverse transcription and quantitative polymerase chain reaction revealed that UDP-glc modulated mRNA levels of IL-8/CXCL8.	Uridine Diphosphate Glucose	89-96	C-X-C motif chemokine ligand 8	Homo sapiens	127-132
16236565-4	2005	We have done several experiments using the rat ulnar loading model that demonstrate that (1) high-resolution [18F]NaF PET can detect newly created microdamage in vivo; (2) the microdamage detected in this way is co-localized with damage detected by histological and autoradiographic procedures; and (3) high-resolution [18F]NaF PET can distinguish between the effects of mechanical loading that does not produce damage and fatigue loading that creates microdamage.	Fluorine-18	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	114-117
16040184-6	2005	Under stimulated conditions, arginine decreased IL-8 and Mig mRNA level (57% and 39%, for 0.1 vs. 2 mmol/l l-arginine, P&lt;0.05, respectively), and production (respectively, 28 and 23%, both P&lt;0.05).	Arginine	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
16040184-9	2005	Use of NG-Methyl-l-arginine acetate, a NOS inhibitor which prevents arginine-induced NO production, suppressed the arginine-induced IL-8 inhibition (P&lt;0.05).	Methylarginine	7-35	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
16040184-9	2005	Use of NG-Methyl-l-arginine acetate, a NOS inhibitor which prevents arginine-induced NO production, suppressed the arginine-induced IL-8 inhibition (P&lt;0.05).	Arginine	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
16040184-9	2005	Use of NG-Methyl-l-arginine acetate, a NOS inhibitor which prevents arginine-induced NO production, suppressed the arginine-induced IL-8 inhibition (P&lt;0.05).	Arginine	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
16040184-10	2005	In HCT-8 cells, arginine enhanced cytokine-induced NO production, reduced IL-8 and Mig production and mRNA level and had no effects on other assessed chemokines.	Arginine	16-24	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
16040184-11	2005	In conclusion, arginine-induced IL-8 inhibition in HCT-8 cells involves NO pathway under inflammatory conditions.	Arginine	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
16263754-5	2005	Moreover, inhibitors of MAPK (U0126 and SB203580) significantly reduced the IL-8 production, while the inhibition of NF-kappaB (pyrrolidinedithiocarbamate and retrovirus containing dominant-negative IkappaB alpha plasmid) did not affect the IL-8 expression increased by CpG ODN.	U 0126	30-35	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
16263754-0	2005	CpG oligodeoxynucleotides induce IL-8 expression in CD34+ cells via mitogen-activated protein kinase-dependent and NF-kappaB-independent pathways.	Oligodeoxyribonucleotides	4-25	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
16263754-5	2005	Moreover, inhibitors of MAPK (U0126 and SB203580) significantly reduced the IL-8 production, while the inhibition of NF-kappaB (pyrrolidinedithiocarbamate and retrovirus containing dominant-negative IkappaB alpha plasmid) did not affect the IL-8 expression increased by CpG ODN.	SB 203580	40-48	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
17086498-0	2005	Combined effect of 25-hydroxycholesterol and IL-1beta on IL-8 production in human colon carcinoma cell line (Caco-2).	25-hydroxycholesterol	19-40	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
17086498-5	2005	Pre-treatment of Caco-2 cells with 25-hydroxycholesterol significantly enhanced IL-1beta-induced IL-8 expression at both mRNA and protein levels.	25-hydroxycholesterol	35-56	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
17086498-7	2005	Furthermore, pre-treatment with 25-hydroxycholesterol, followed by IL-1beta stimulation, enhanced IL-8 promoter activity beyond that observed with IL-1beta alone.	25-hydroxycholesterol	32-53	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
17086498-8	2005	These results suggest that 25-hydroxycholesterol enhances IL-1beta-induced IL-8 production, possibly by enhancing promoter activity.	25-hydroxycholesterol	27-48	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
16337471-6	2005	The production of IL-8 and monocyte chemoattractant protein 1 in response to either IgE alone or IgE and anti-IgE was enhanced by preincubation of the cells in IL-4 and was inhibited by preincubation of the cells with dexamethasone.	Dexamethasone	218-231	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
16273203-0	2005	Vesnarinone inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing the expression of vascular endothelial growth factor and interleukin-8.	vesnarinone	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	169-182
16273203-7	2005	These findings suggest that vesnarinone can suppress the angiogenesis and growth of oral squamous cell carcinoma cells by inhibiting the expression of VEGF and IL-8 involved in blockade of NF-kappaB activity.	vesnarinone	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
16819095-7	2005	In the present study we determined whether ozone exposure enhances DEP effect on interleukin-8 (IL-8) gene expression in human airway epithelial cells.	Ozone	43-48	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
16819095-7	2005	In the present study we determined whether ozone exposure enhances DEP effect on interleukin-8 (IL-8) gene expression in human airway epithelial cells.	Ozone	43-48	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
16819095-9	2005	The increased DEP-induced IL-8 gene expression following ozone exposure was attributed to ozone-induced increase in the activity of the transcription factors NF-kappaB and NF-IL6.	Ozone	57-62	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
16354411-7	2005	Dexamethasone (100 nM) not only inhibited PGE2, PGF(2alpha), IL-6 and IL-8 production but also strongly suppressed the expression of COX-2 mRNA and protein.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
16123309-7	2005	Treatment of TNF-alpha-stimulated HT29 cells with EGCG dose-dependently inhibited the synthesis of IL-8, MIP-3alpha, and PGE2.	epigallocatechin gallate	50-54	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
16123309-8	2005	Treatment with EGCG also inhibited the production of IL-8 and MIP-3alpha in TNF-alpha-stimulated T84 cells.	epigallocatechin gallate	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
16224818-4	2005	Recombinant MIF counter-regulated in a dose-dependent fashion dexamethasone inhibition of TNF and IL-8 production by RAW 264.7 macrophages and U-937 promonocytes stimulated with lipopolysaccharides (LPS) or with LPS plus phorbol 12-myristate 13-acetate.	Dexamethasone	62-75	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
16306601-10	2005	Treatment with the HDAC inhibitor trichostatin A blocks attenuation of IL-8 transcription.	trichostatin A	34-48	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
16373705-0	2005	AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes.	AP23846	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	111-124
15893939-4	2005	(AAR)IL-8 could be easily purified by one-step SP-Sepharose fast flow column after the lysate of recombinant bacterial cells was heated at 70 degrees C for 10 min.	sp-sepharose	47-59	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
17292102-10	2005	In contrast, MWCNT-induced IL-8 release was reduced when exposed to 1% or 5% Pluronic F127 (P &lt; .05).	mwcnt	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
16229003-5	2005	LTB(4) and IL-8 in EBC were analyzed by specific enzyme immunoassay kits (EIA).	NSC638702	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
16229003-12	2005	Our data suggest that EBC is suitable for evaluating neutrophil inflammatory mediators (LTB(4), IL-8, and pH) involved in the response to pulmonary bacterial colonization in CF children.	NSC638702	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
18404520-3	2005	The aim of our study was to investigate the mechanism responsible for the priming effect of extracellular nucleotides on reactive oxygen species (ROS) production induced in human neutrophils by two different chemoattractants: formyl-methionyl-leucyl-phenylalanine (fMLP) and interleukin-8 (IL-8).	Reactive Oxygen Species	121-144	C-X-C motif chemokine ligand 8	Homo sapiens	275-288
15946834-5	2005	The budesonide-treated subjects had significant reductions in IL-8 levels in the BAL after therapy (mean+/-sem, 1.53+/-0.72 at baseline vs. 0.70+/-0.48 ng/ml at 6 months, P=0.004) and a reduction in the mean percentages of neutrophils (17.16+/-2.67% vs. 13.25+/-2.28% P=0.002).	Budesonide	4-14	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
15946834-7	2005	In stable patients with COPD, treatment with inhaled budesonide for a period of 6 months has a positive effect on markers of lung inflammation, as assessed by reduction in percentage neutrophils and IL-8 concentration in BAL.	Budesonide	53-63	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
18404520-3	2005	The aim of our study was to investigate the mechanism responsible for the priming effect of extracellular nucleotides on reactive oxygen species (ROS) production induced in human neutrophils by two different chemoattractants: formyl-methionyl-leucyl-phenylalanine (fMLP) and interleukin-8 (IL-8).	Reactive Oxygen Species	121-144	C-X-C motif chemokine ligand 8	Homo sapiens	290-294
18404520-3	2005	The aim of our study was to investigate the mechanism responsible for the priming effect of extracellular nucleotides on reactive oxygen species (ROS) production induced in human neutrophils by two different chemoattractants: formyl-methionyl-leucyl-phenylalanine (fMLP) and interleukin-8 (IL-8).	Reactive Oxygen Species	146-149	C-X-C motif chemokine ligand 8	Homo sapiens	275-288
18404520-3	2005	The aim of our study was to investigate the mechanism responsible for the priming effect of extracellular nucleotides on reactive oxygen species (ROS) production induced in human neutrophils by two different chemoattractants: formyl-methionyl-leucyl-phenylalanine (fMLP) and interleukin-8 (IL-8).	Reactive Oxygen Species	146-149	C-X-C motif chemokine ligand 8	Homo sapiens	290-294
16226369-4	2005	Addition of NaF, forskolin or sodium nitroprusside, activators of the inositol phosphates (IPs), cAMP and cGMP pathways, significantly increased their respective messengers in villous explants but failed to affect the hPL and hCG releases from syncytiotrophoblast.	Inositol Phosphates	70-89	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
16494031-4	2005	RESULT: Compared with the control group, the levels of EGF, TGF-alpha, IL-1beta, IL-6 and IL-8 were significantly increased by treatment with Aloe coarse polysaccharide (P &lt; 0.05, P &lt; 0.01) and in a dose dependent manner, and the levels of TGF-beta1 and TNF were also increased but no statistical significance.	Polysaccharides	154-168	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
16494031-5	2005	CONCLUSION: Aloe coarse polysaccharide may promote keratinocytes to secrete EGF, TGF-alpha, IL-1beta, IL-6 and IL-8.	Polysaccharides	24-38	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
16325749-0	2005	Linoleic acid, but not oleic acid, upregulates production of interleukin-8 by human vascular smooth muscle cells via arachidonic acid metabolites under conditions of oxidative stress.	Linoleic Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
16325749-0	2005	Linoleic acid, but not oleic acid, upregulates production of interleukin-8 by human vascular smooth muscle cells via arachidonic acid metabolites under conditions of oxidative stress.	Oleic Acid	3-13	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
16325749-0	2005	Linoleic acid, but not oleic acid, upregulates production of interleukin-8 by human vascular smooth muscle cells via arachidonic acid metabolites under conditions of oxidative stress.	Arachidonic Acid	117-133	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
16325749-2	2005	We hypothesized that increased levels of LA under conditions of oxidative stress would increased production of IL-8 by vascular smooth muscle cells because LA is the dietary precursor to arachidonic acid (AA) and its metabolites that mediate inflammation.	Arachidonic Acid	187-203	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
16325749-7	2005	RESULTS: Exposure of cells to OxLA, but not to OxOA, significantly increased production of IL-8.	oxla	30-34	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
16325749-9	2005	Nordihydroguaiaretic acid, an inhibitor of the lipoxygenase pathway, blocked IL-8 and leukotriene B4 (LTB4) production induced by OxLA, whereas indomethacin, an inhibitor of the cyclooxygenase pathway, blocked IL-8, prostaglandin E2 (PGE2), and thromboxane B2 (TXB2) production.	Masoprocol	0-25	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
16325749-9	2005	Nordihydroguaiaretic acid, an inhibitor of the lipoxygenase pathway, blocked IL-8 and leukotriene B4 (LTB4) production induced by OxLA, whereas indomethacin, an inhibitor of the cyclooxygenase pathway, blocked IL-8, prostaglandin E2 (PGE2), and thromboxane B2 (TXB2) production.	Masoprocol	0-25	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
16325749-9	2005	Nordihydroguaiaretic acid, an inhibitor of the lipoxygenase pathway, blocked IL-8 and leukotriene B4 (LTB4) production induced by OxLA, whereas indomethacin, an inhibitor of the cyclooxygenase pathway, blocked IL-8, prostaglandin E2 (PGE2), and thromboxane B2 (TXB2) production.	oxla	130-134	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
16325749-9	2005	Nordihydroguaiaretic acid, an inhibitor of the lipoxygenase pathway, blocked IL-8 and leukotriene B4 (LTB4) production induced by OxLA, whereas indomethacin, an inhibitor of the cyclooxygenase pathway, blocked IL-8, prostaglandin E2 (PGE2), and thromboxane B2 (TXB2) production.	oxla	130-134	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
16226369-4	2005	Addition of NaF, forskolin or sodium nitroprusside, activators of the inositol phosphates (IPs), cAMP and cGMP pathways, significantly increased their respective messengers in villous explants but failed to affect the hPL and hCG releases from syncytiotrophoblast.	Inositol Phosphates	91-94	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
16226369-4	2005	Addition of NaF, forskolin or sodium nitroprusside, activators of the inositol phosphates (IPs), cAMP and cGMP pathways, significantly increased their respective messengers in villous explants but failed to affect the hPL and hCG releases from syncytiotrophoblast.	Cyclic AMP	97-101	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
16226369-4	2005	Addition of NaF, forskolin or sodium nitroprusside, activators of the inositol phosphates (IPs), cAMP and cGMP pathways, significantly increased their respective messengers in villous explants but failed to affect the hPL and hCG releases from syncytiotrophoblast.	Cyclic GMP	106-110	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
16262287-4	2005	A (PAH-Naf)(n) film possesses a water contact angle of around 105 degrees, whereas the contact angle of a (PAH-Naf)(4)-(PAH-PAA)(m) multilayer is around 50 degrees.	Water	32-37	C-X-C motif chemokine ligand 8	Homo sapiens	7-10
16272305-3	2005	Estradiol inhibited the IL-1beta-mediated mRNA expression and secretion of human beta-defensin-2 and CXCL8 by uterine epithelial cells while progesterone had no effect.	Estradiol	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	101-106
16277535-1	2005	In situ infrared visible sum frequency generation spectroscopy (SFG) is used to examine the structure of water at the Ag-water interface in NaF and KF electrolyte solutions.	Water	105-110	C-X-C motif chemokine ligand 8	Homo sapiens	140-143
16181613-9	2005	RT-PCR results showed that honokiol suppressed NF-kappaB-regulated inflammatory and carcinogenic gene products including MMP-9, TNF-alpha, IL-8, ICAM-1 and MCP-1.	honokiol	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
16262287-4	2005	A (PAH-Naf)(n) film possesses a water contact angle of around 105 degrees, whereas the contact angle of a (PAH-Naf)(4)-(PAH-PAA)(m) multilayer is around 50 degrees.	pah-paa	120-127	C-X-C motif chemokine ligand 8	Homo sapiens	111-114
16251427-8	2005	After 24 hours, enzyme-linked immunosorbent assay measurements indicated that thrombin (0.1 to 2.5 U/ml) elicited a dose-dependent elevation in secreted IL-8 (P&lt;0.05) with 2.5 U/ml of thrombin increasing IL-8 levels by &gt;14-fold in E2 and E2+medroxyprogesterone incubations.	Medroxyprogesterone	247-266	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
16115878-4	2005	Here we showed that within 3 min, IL-8 treatment enhanced the Btk- and ERK1/2-dependent phosphorylation of p47(phox), as well as the recruitment of flavocytochrome b(558), p47(phox), and Rac2 into cholesterol-enriched detergent-resistant microdomains (or lipid rafts).	Cholesterol	197-208	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
16115878-6	2005	Moreover, methyl-beta-cyclodextrin, which disrupts lipid rafts, inhibited IL-8-induced priming in response to fMLP.	methyl-beta-cyclodextrin	10-34	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
16212625-7	2005	IL1-beta stimulated IL-8 production was significantly increased in rapidly growing hTBEC cultures (n = 8) treated with cyclosporin (p = 0.049).	Cyclosporine	119-130	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
16212625-9	2005	Inhibition of hTBEC growth, stimulation of IL-8 production and long-term effects on mucociliary phenotype and intact multi-layered epithelium suggest that cyclosporin may have a direct toxic effect on airway epithelium after transplantation.	Cyclosporine	155-166	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
15987794-3	2005	METHODS AND RESULTS: The authors developed a double transgenic mouse model with doxycycline induced human IL-8 expression restricted to intestinal epithelial cells.	Doxycycline	80-91	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
16276481-3	2005	Accordingly, pro-inflammatory agonists and oxygen radicals induce IL-8.	Reactive Oxygen Species	43-58	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
16214039-10	2005	Sublethal superoxide dose evoked: (1) proinflammatory state manifested by increased IL-8 mRNA expression and CAM on the endothelial surface, (2) HUVEC apoptosis and activated endothelial NADPH oxidase, (3) increase in intracellular tissue factor, and (4) decrease in eNOS mRNA and protein and up-regulation of iNOS mRNA.	Superoxides	10-20	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
16220077-5	2005	C-reactive protein could augment the production of reactive oxygen species (ROS) as measured by chemiluminescence and inhibitors of NAD(P)H oxidase (DPI and PAO) and ROS scavengers (superoxide dismutase, catalase, and 1% dimethyl sulphoxide) abolished C-reactive protein-induced IL-8 secretion.	Reactive Oxygen Species	51-74	C-X-C motif chemokine ligand 8	Homo sapiens	279-283
16220077-5	2005	C-reactive protein could augment the production of reactive oxygen species (ROS) as measured by chemiluminescence and inhibitors of NAD(P)H oxidase (DPI and PAO) and ROS scavengers (superoxide dismutase, catalase, and 1% dimethyl sulphoxide) abolished C-reactive protein-induced IL-8 secretion.	Reactive Oxygen Species	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	279-283
16220077-7	2005	The inhibitors of ERK 1/2 (PD98059), p38 (SB203580) MAPK, and NF-kappaB (PDTC and MG132) significantly decreased C-reactive protein-induced IL-8 secretion in human monocytes.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	27-34	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
16220077-7	2005	The inhibitors of ERK 1/2 (PD98059), p38 (SB203580) MAPK, and NF-kappaB (PDTC and MG132) significantly decreased C-reactive protein-induced IL-8 secretion in human monocytes.	SB 203580	42-50	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
16118056-4	2005	Addition of budesonide to the apical side of Caco-2 cells, decreased both IL-8 and ENA-78 mRNA levels in a dose dependent manner.	Budesonide	12-22	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
16220077-7	2005	The inhibitors of ERK 1/2 (PD98059), p38 (SB203580) MAPK, and NF-kappaB (PDTC and MG132) significantly decreased C-reactive protein-induced IL-8 secretion in human monocytes.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	82-87	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
16220077-9	2005	Thus, our data indicate that C-reactive protein at pathologic levels increases IL-8 secretion and mRNA via enhancing ROS derived mainly from NAD(P)H oxidase and the subsequent activation of ERK1/2, p38 MAPK, and NF-kappaB.	Reactive Oxygen Species	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
15950427-2	2005	Particulate wear debris induced NF-kappaB activation, the major transcriptional regulator of IL-8 and MCP-1 pro-inflammatory genes and, indeed, both IL-8 and MCP-1 chemokine gene expressions were upregulated in titanium particulate-stimulated human osteoblasts.	Titanium	211-219	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
15950427-2	2005	Particulate wear debris induced NF-kappaB activation, the major transcriptional regulator of IL-8 and MCP-1 pro-inflammatory genes and, indeed, both IL-8 and MCP-1 chemokine gene expressions were upregulated in titanium particulate-stimulated human osteoblasts.	Titanium	211-219	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
15950427-4	2005	Transfection of a dominant negative mutant IkappaBalpha protein that cannot be serine phosphorylated led to suppression of IL-8 promoter activity.	Serine	79-85	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
16308137-8	2005	Among the groups with preeclamptic plasma stimulation, intracellular CAM-1 expression on ECs and CD11b and IL-8 receptor expressions on PMNs were lower with 500 and 1000 microM than with 300 microM of GLN.	Glutamine	201-204	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
16308137-9	2005	IL-8 production from ECs and PMNs was also lower with 500 and 1000 microM than with 300 microM of GLN.	Glutamine	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
16308137-14	2005	GLN administration at levels similar to or higher than physiologic concentrations decreased IL-8 and CAM expressions, and PMN transmigration decreased after stimulation with preeclamptic plasma.	Glutamine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
16084078-5	2005	Among the arsenic groups, the expression of CAMs on ECs and CD11b, and IL-8 receptor on PMNs was lowest with 0 microM compared with the other GLN concentrations.	Glutamine	142-145	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
16084078-7	2005	IL-8 secretions from ECs and PMNs were higher with 300 muM than with 600 and 1000 microM GLN, and this was consistent with the expression of the IL-8 receptor on PMNs.	Glutamine	89-92	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
16084078-7	2005	IL-8 secretions from ECs and PMNs were higher with 300 muM than with 600 and 1000 microM GLN, and this was consistent with the expression of the IL-8 receptor on PMNs.	Glutamine	89-92	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
16084078-12	2005	Glutamine administration at levels similar to or higher than physiological concentrations reduced IL-8 and adhesion molecule expression; PMN transmigration was also decreased after stimulation with arsenic.	Glutamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
16061772-5	2005	Furthermore, we show for the first time that cigarette smoke synergizes with proinflammatory cytokines IL-1beta and tumor necrosis factor-alpha, and it is this interaction that confers steroid resistance to smoke-induced CXCL8 release.	Steroids	185-192	C-X-C motif chemokine ligand 8	Homo sapiens	221-226
15888346-0	2005	Novel p38 MAP kinase inhibitor R-130823 suppresses IL-6, IL-8 and MMP-13 production in spheroid culture of human synovial sarcoma cell line SW 982.	2-(4-fluorophenyl)-4-(1-phenethyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(pyridin-4-yl)-1H-pyrrole	31-39	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
15888346-8	2005	A novel p38 MAP kinase inhibitor, R-130823, inhibited the release of IL-6, IL-8 and MMP-13 in a concentration-dependent manner, but not that of IL-1beta or MMP-2.	2-(4-fluorophenyl)-4-(1-phenethyl-1,2,3,6-tetrahydropyridin-4-yl)-3-(pyridin-4-yl)-1H-pyrrole	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
15893895-8	2005	CA also inhibited interleukin-8 and tumor necrosis factor-alpha secretion from the phorbol 12-myristate 13-acetate and A23187-induced HMC-1 cells (human mast cell line).	Tetradecanoylphorbol Acetate	83-114	C-X-C motif chemokine ligand 8	Homo sapiens	18-63
16210650-3	2005	We now report that LPA potently induces the generation of proinflammatory chemokines (MIP-1beta, IL-8, and MCP-1) by hMCs by a mechanism that absolutely requires IL-4.	lysophosphatidic acid	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
16273626-12	2005	The concentrations of IL-6 and IL-8 in ciglitazone group were lower than those in inflammatory control group (P&lt;0.05).	ciglitazone	39-50	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
15893895-8	2005	CA also inhibited interleukin-8 and tumor necrosis factor-alpha secretion from the phorbol 12-myristate 13-acetate and A23187-induced HMC-1 cells (human mast cell line).	Calcimycin	119-125	C-X-C motif chemokine ligand 8	Homo sapiens	18-63
15976375-2	2005	Binding of IL-8 to heparan sulfate (HS)-containing proteoglycans (HSPG) facilitates binding of the chemokine to its specific receptor, stabilizes and prolongs IL-8 activity, and protects it from proteolysis.	Heparitin Sulfate	19-34	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
16185062-1	2005	We have used trimethylamine N-oxide (TMAO), a protecting osmolyte, to dissect the complex thermodynamic linkages involved in the interaction between the chemokine interleukin-8 (IL-8) and the N-domain of its receptor CXCR1.	trimethyloxamine	13-35	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
16185062-1	2005	We have used trimethylamine N-oxide (TMAO), a protecting osmolyte, to dissect the complex thermodynamic linkages involved in the interaction between the chemokine interleukin-8 (IL-8) and the N-domain of its receptor CXCR1.	trimethyloxamine	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
15976375-2	2005	Binding of IL-8 to heparan sulfate (HS)-containing proteoglycans (HSPG) facilitates binding of the chemokine to its specific receptor, stabilizes and prolongs IL-8 activity, and protects it from proteolysis.	Heparitin Sulfate	19-34	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
15976375-2	2005	Binding of IL-8 to heparan sulfate (HS)-containing proteoglycans (HSPG) facilitates binding of the chemokine to its specific receptor, stabilizes and prolongs IL-8 activity, and protects it from proteolysis.	Heparitin Sulfate	36-38	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
15976375-2	2005	Binding of IL-8 to heparan sulfate (HS)-containing proteoglycans (HSPG) facilitates binding of the chemokine to its specific receptor, stabilizes and prolongs IL-8 activity, and protects it from proteolysis.	Heparitin Sulfate	36-38	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
16413516-4	2005	Adenosine pretreatment resulted in a reduction in IL-8 expression and secretion in response to TNF-alpha, IL-1, LPS, and PMA.	Adenosine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
16279568-11	2005	Compared with placebo use, montelukast treatment decreased serum and sputum levels of eosinophil cationic protein and IL-8, decreased sputum levels of myeloperoxidase, and increased serum and sputum levels of IL-10 (P &lt; .001 for all).	montelukast	27-38	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
16236838-7	2005	RESULTS: Formoterol therapy significantly reduced sputum IL-8 levels and neutrophil numbers compared to placebo.	Formoterol Fumarate	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
16236838-8	2005	There was a significant correlation between the reduction in sputum IL-8 levels and the number of neutrophils, indicating that formoterol may attenuate neutrophilic airway inflammation by inhibiting IL-8 production.	Formoterol Fumarate	127-137	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
16000389-7	2005	Freshly isolated monocytes responded to the PAR-2 AP ASKH 95 (2-furoyl-LIGKV-OH) with the generation of a calcium flux and production of interleukin (IL)-1beta, IL-6, and IL-8.	2-furoyl-leucyl-isoleucyl-glycyl-lysyl-valine	62-79	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
16236838-8	2005	There was a significant correlation between the reduction in sputum IL-8 levels and the number of neutrophils, indicating that formoterol may attenuate neutrophilic airway inflammation by inhibiting IL-8 production.	Formoterol Fumarate	127-137	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
16236942-7	2005	RESULTS: Dexamethasone modulated the SIRS with lower proinflammatory (IL-6, IL-8) and higher antiinflammatory (IL-10) IL levels.	Dexamethasone	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
16285544-3	2005	NaF of four different concentrations (1.23%, 2%, 3% and 0%) was added into 35% phosphoric acid.	phosphoric acid	79-94	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
16183791-2	2005	Since fluoride is known as an inhibitor of glycolytic enzymes, we investigated the possible connection between NaF-induced apoptosis and glycolysis in human promyelocytic leukemia HL-60 cells.	Fluorides	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	111-114
16183791-5	2005	Utilization of glucose was nearly halted by NaF, whereas that of glutamine was rather enhanced.	Glucose	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	44-47
16215365-10	2005	Interleukin-8 increased significantly in the bronchoalveolar lavage fluid (BALF) in supine-HFOV and prone-HFOV groups compared with prone-CV and supine-CV.	hfov	91-95	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
16215365-10	2005	Interleukin-8 increased significantly in the bronchoalveolar lavage fluid (BALF) in supine-HFOV and prone-HFOV groups compared with prone-CV and supine-CV.	hfov	106-110	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
16308450-4	2005	We have found, that pentazocine, SKF 10 047, dextrorphan reduce spontaneous secretion of IL-8, IL-6 and IL-10 and selectively changes synthesis of IL-4 by Jurkat human T lymphocyte cells lines.	Pentazocine	20-31	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
16308450-4	2005	We have found, that pentazocine, SKF 10 047, dextrorphan reduce spontaneous secretion of IL-8, IL-6 and IL-10 and selectively changes synthesis of IL-4 by Jurkat human T lymphocyte cells lines.	1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
16308450-4	2005	We have found, that pentazocine, SKF 10 047, dextrorphan reduce spontaneous secretion of IL-8, IL-6 and IL-10 and selectively changes synthesis of IL-4 by Jurkat human T lymphocyte cells lines.	Dextrorphan	45-56	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
16308450-6	2005	Spontaneous secretion of IL-4 and IL-8 correlates with synthesis of nitric oxide, suggesting that NO and transitory S-nitrosylation of up-stream proteins participate in the sigma ligand dependent expression of IL-4 and IL-8 genes.	Nitric Oxide	68-80	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
16308450-6	2005	Spontaneous secretion of IL-4 and IL-8 correlates with synthesis of nitric oxide, suggesting that NO and transitory S-nitrosylation of up-stream proteins participate in the sigma ligand dependent expression of IL-4 and IL-8 genes.	Nitric Oxide	68-80	C-X-C motif chemokine ligand 8	Homo sapiens	219-223
16150115-11	2005	Interleukin-8 and tumor necrosis factor-alpha levels tended to be lower in individuals who had taken melatonin following hard physical activity and a larger sample size may show significance.	Melatonin	101-110	C-X-C motif chemokine ligand 8	Homo sapiens	0-45
16150112-1	2005	We evaluated the presence of the melatonin metabolite N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), in cerebrospinal fluid (CSF) of patients with viral meningitis (n = 20) and control samples (n = 8) and correlate AFMK levels with inflammatory markers such as cellularity, protein, tumor necrosis factor (TNF)-alpha, interleukin (IL)-8 and IL-1beta levels.	Melatonin	33-42	C-X-C motif chemokine ligand 8	Homo sapiens	319-337
16123332-2	2005	Peroxynitrite (ONOO-) may function as an intracellular signal for the production of IL-8; however, it is not known whether CRP regulates these events.	Peroxynitrous Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
16192891-11	2005	Exogenous H2O2 enhanced IL-8 secretion and N-acetyl cysteine (NAC) prevented IL-1alpha-induced ROS production and IL-8 secretion.	Acetylcysteine	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
16192891-15	2005	CONCLUSIONS: These results suggest that MAPK/AP-1 and ROS/NF-kappaB signaling pathways are involved in IL-1alpha-induced IL-8 secretion and that these paracrine signaling pathways enhance endothelial cell proliferation.	Reactive Oxygen Species	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
16123332-0	2005	Loss of pentameric symmetry in C-reactive protein induces interleukin-8 secretion through peroxynitrite signaling in human neutrophils.	Peroxynitrous Acid	90-103	C-X-C motif chemokine ligand 8	Homo sapiens	58-71
16192891-0	2005	Interleukin-1alpha enhances IL-8 secretion through p38 mitogen-activated protein kinase and reactive oxygen species signaling in human pancreatic cancer cells.	Reactive Oxygen Species	92-115	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
16192891-11	2005	Exogenous H2O2 enhanced IL-8 secretion and N-acetyl cysteine (NAC) prevented IL-1alpha-induced ROS production and IL-8 secretion.	Hydrogen Peroxide	10-14	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
16192891-11	2005	Exogenous H2O2 enhanced IL-8 secretion and N-acetyl cysteine (NAC) prevented IL-1alpha-induced ROS production and IL-8 secretion.	Acetylcysteine	43-60	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
16157236-6	2005	In addition, DL-homocysteine at the pathophysiologic dose of 25 microg/mL (185 microM) induced mRNA and protein expressions of inflammatory cytokines tumor necrosis factor-alpha, IL-1beta, interleukin-6, interleukin-8, and interleukin-12.	DL-Homocysteine	13-28	C-X-C motif chemokine ligand 8	Homo sapiens	204-217
16140223-10	2005	Inhaled steroids resulted in reduced levels of IL-1 beta, IL-6, IL-8, IL-10, and IL-12 (all: P&lt;0.01) in stable COPD (all: ex-smokers) with dose dependency for IL-8, IL-1 beta and IL-12.	Steroids	8-16	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
16140223-10	2005	Inhaled steroids resulted in reduced levels of IL-1 beta, IL-6, IL-8, IL-10, and IL-12 (all: P&lt;0.01) in stable COPD (all: ex-smokers) with dose dependency for IL-8, IL-1 beta and IL-12.	Steroids	8-16	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
16123332-2	2005	Peroxynitrite (ONOO-) may function as an intracellular signal for the production of IL-8; however, it is not known whether CRP regulates these events.	oxido nitrite	15-20	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
16309584-0	2005	Heme oxygenase-1-dependent and -independent regulation of angiogenic genes expression: effect of cobalt protoporphyrin and cobalt chloride on VEGF and IL-8 synthesis in human microvascular endothelial cells.	cobaltiprotoporphyrin	97-118	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
16123332-4	2005	We studied the impact of human native CRP and bioengineered mCRP that cannot rearrange into the pentameric structure on ONOO- formation and ONOO--mediated IL-8 gene expression in human leukocytes.	onoo	140-144	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
16309584-0	2005	Heme oxygenase-1-dependent and -independent regulation of angiogenic genes expression: effect of cobalt protoporphyrin and cobalt chloride on VEGF and IL-8 synthesis in human microvascular endothelial cells.	cobaltous chloride	123-138	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
16123332-5	2005	Incubation of human whole blood or isolated neutrophils with mCRP (0.1 to 100 microg/mL) for 4 hours increased IL-8 gene expression and secretion that was blocked approximately 70% by the NO synthase inhibitor Nomega-nitro-L-arginine methyl ester (L-NAME).	NG-Nitroarginine Methyl Ester	210-246	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
16123332-5	2005	Incubation of human whole blood or isolated neutrophils with mCRP (0.1 to 100 microg/mL) for 4 hours increased IL-8 gene expression and secretion that was blocked approximately 70% by the NO synthase inhibitor Nomega-nitro-L-arginine methyl ester (L-NAME).	NG-Nitroarginine Methyl Ester	248-254	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
16309584-3	2005	Here we determined the effect of CoPPIX and CoCl2 on the expression of vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8), the two major angiogenic mediators, in human microvascular endothelial cells (HMEC-1).	coppix	33-39	C-X-C motif chemokine ligand 8	Homo sapiens	117-130
16408727-5	2005	RESULTS: IL-5, IL-6 and IL-8 levels in both AR and NAR groups were significantly increased (all P &lt; 0.01 for AR group; P &lt; 0.05, 0.05, 0.01, respectively, for NAR group, as compared with normal group), and the levels were much higher in AR group than that in NAR group (P &lt; 0.01, 0.05, 0.01, respectively).	Argon	44-46	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
16123332-7	2005	Native CRP had no detectable effect at 4 hours, whereas it enhanced IL-8 release after a 24-hour incubation that was blocked by L-NAME.	NG-Nitroarginine Methyl Ester	128-134	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
16309584-3	2005	Here we determined the effect of CoPPIX and CoCl2 on the expression of vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8), the two major angiogenic mediators, in human microvascular endothelial cells (HMEC-1).	coppix	33-39	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
16309584-3	2005	Here we determined the effect of CoPPIX and CoCl2 on the expression of vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8), the two major angiogenic mediators, in human microvascular endothelial cells (HMEC-1).	cobaltous chloride	44-49	C-X-C motif chemokine ligand 8	Homo sapiens	117-130
16123332-9	2005	These results suggest that loss of the pentameric symmetry in CRP, resulting in formation of mCRP, leads to IL-8 release from human neutrophils via peroxynitrite-mediated activation of nuclear factor-kappaB and activator protein-1.	Peroxynitrous Acid	148-161	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
16309584-3	2005	Here we determined the effect of CoPPIX and CoCl2 on the expression of vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8), the two major angiogenic mediators, in human microvascular endothelial cells (HMEC-1).	cobaltous chloride	44-49	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
16142980-8	2005	Besides, while the condensation of silica took place after addition of NaF, the N value increased only very little with time up to the point where a small amount of mesostructured material precipitated out.	Silicon Dioxide	35-41	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
16309584-4	2005	CoPPIX induced HO-1 expression and strongly enhanced VEGF and IL-8 synthesis, through the activation of VEGF and IL-8 promoters.	coppix	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
16309584-4	2005	CoPPIX induced HO-1 expression and strongly enhanced VEGF and IL-8 synthesis, through the activation of VEGF and IL-8 promoters.	coppix	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
16148150-0	2005	Pyocyanin and its precursor phenazine-1-carboxylic acid increase IL-8 and intercellular adhesion molecule-1 expression in human airway epithelial cells by oxidant-dependent mechanisms.	Pyocyanine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	65-107
16148150-0	2005	Pyocyanin and its precursor phenazine-1-carboxylic acid increase IL-8 and intercellular adhesion molecule-1 expression in human airway epithelial cells by oxidant-dependent mechanisms.	1-phenazinecarboxylic acid	28-55	C-X-C motif chemokine ligand 8	Homo sapiens	65-107
16148150-5	2005	Moreover, phenazines enhanced cytokine-dependent increases in IL-8 and ICAM-1.	Phenazines	10-20	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
16148150-7	2005	The thiol antioxidant N-acetyl cysteine, extracellular catalase, and inducible NO synthase inhibitors inhibited ICAM-1 and IL-8 increases in response to both phenazines.	Sulfhydryl Compounds	4-9	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
16148150-7	2005	The thiol antioxidant N-acetyl cysteine, extracellular catalase, and inducible NO synthase inhibitors inhibited ICAM-1 and IL-8 increases in response to both phenazines.	Acetylcysteine	22-39	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
16148150-7	2005	The thiol antioxidant N-acetyl cysteine, extracellular catalase, and inducible NO synthase inhibitors inhibited ICAM-1 and IL-8 increases in response to both phenazines.	Phenazines	158-168	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
16148150-10	2005	These studies suggest that P. aeruginosa phenazines coordinately up-regulate chemokines (IL-8) and adhesion molecules (ICAM-1) by mechanisms that are, at least in part, oxidant dependent.	Phenazines	41-51	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
16092118-6	2005	NF-kappaB was constitutively active in all human pancreatic carcinoma cell lines evaluated and liposomal curcumin consistently suppressed NF-kappaB binding (electrophoretic mobility gel shift assay) and decreased the expression of NF-kappaB-regulated gene products, including cyclooxygenase-2 (immunoblots) and interleukin-8 (enzyme-linked immunoassay), both of which have been implicated in tumor growth/invasiveness.	Curcumin	105-113	C-X-C motif chemokine ligand 8	Homo sapiens	311-324
16410222-5	2005	Importantly, atorvastatin at the micromolar concentrations diminished the production of interleukin (IL)-8, a proinflammatory and proangiogenic chemokine, and inhibited the synthesis of urokinase plasminogen activator (uPA), a potent proinflammatory mediator.	Atorvastatin	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	88-106
16141522-6	2005	We found that leflunomide or T0 could significantly inhibit the mRNA overexpression of interleukin-8 and intercellular adhesion molecule-1 in keratinocytes induced by anthralin.	Leflunomide	14-25	C-X-C motif chemokine ligand 8	Homo sapiens	87-138
16141522-6	2005	We found that leflunomide or T0 could significantly inhibit the mRNA overexpression of interleukin-8 and intercellular adhesion molecule-1 in keratinocytes induced by anthralin.	t0	29-31	C-X-C motif chemokine ligand 8	Homo sapiens	87-138
16141522-6	2005	We found that leflunomide or T0 could significantly inhibit the mRNA overexpression of interleukin-8 and intercellular adhesion molecule-1 in keratinocytes induced by anthralin.	Anthralin	167-176	C-X-C motif chemokine ligand 8	Homo sapiens	87-138
16266860-9	2005	The neonates assigned to HFOV benefited from early and sustained improvement in gas exchange, with earlier extubation and lower incidence of CLD, as compared to the neonates assigned to sIMV treatment, and showed a significant reduction of serum IL-6, IL-8 and IL-10 over time only when the HFOV treatment was administered.	hfov	25-29	C-X-C motif chemokine ligand 8	Homo sapiens	252-256
15828019-0	2005	Polyamine depletion inhibits NF-kappaB binding to DNA and interleukin-8 production in human chondrocytes stimulated by tumor necrosis factor-alpha.	Polyamines	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	58-71
15828019-7	2005	Moreover, DFMO also decreased IL-8 production without affecting cellular viability.	Eflornithine	10-14	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
16123706-5	2005	The aim of this study was to investigate the effects of root canal sealers N2 (zinc-oxide eugenol based) and AH Plus (epoxy resin based) on the expression of IL-6 and IL-8 mRNA gene in human osteoblastic cell line U2OS cells.	Nitrogen	75-77	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
16103413-3	2005	In this study, a 21-nt synthetic small interfering RNA (siRNA; specifically designed to knockdown interleukin-8 [IL-8] expression) was delivered into HeLa cells.	21-nt	17-22	C-X-C motif chemokine ligand 8	Homo sapiens	98-111
16103413-3	2005	In this study, a 21-nt synthetic small interfering RNA (siRNA; specifically designed to knockdown interleukin-8 [IL-8] expression) was delivered into HeLa cells.	21-nt	17-22	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
16123706-9	2005	Taken together, the activation of IL-6 and IL-8 mRNA gene expression may be one of the pathogenesis of zinc oxide-eugenol based and epoxy resin based root canal sealers-induced periapical inflammation.	Zinc Oxide	103-113	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	44-69	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	44-69	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
16123706-9	2005	Taken together, the activation of IL-6 and IL-8 mRNA gene expression may be one of the pathogenesis of zinc oxide-eugenol based and epoxy resin based root canal sealers-induced periapical inflammation.	Eugenol	114-121	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	44-69	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
15914040-8	2005	RESULTS: PE-TCs produced significantly more IL-6, IL-8, and IL-10 than those of normal-TCs when they were cultured under normoxic condition, P &lt; .05.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	182-185	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	182-185	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	182-185	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
16204787-5	2005	NAC decreased sputum eosinophil cationic protein (318 +/-73 vs. 163 +/-30 ng/ml, P&lt;0.01) and sputum IL-8 (429 +/-80 vs. 347 +/-70 ng/ml, P&lt;0.05).	Acetylcysteine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
16088827-4	2005	Degradation of IL-8 was the result of a single specific cleavage between 59glutamine and 60arginine within the IL-8 C-terminal alpha helix.	59glutamine	73-84	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
16088827-4	2005	Degradation of IL-8 was the result of a single specific cleavage between 59glutamine and 60arginine within the IL-8 C-terminal alpha helix.	59glutamine	73-84	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
16088827-4	2005	Degradation of IL-8 was the result of a single specific cleavage between 59glutamine and 60arginine within the IL-8 C-terminal alpha helix.	60arginine	89-99	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
16088827-4	2005	Degradation of IL-8 was the result of a single specific cleavage between 59glutamine and 60arginine within the IL-8 C-terminal alpha helix.	60arginine	89-99	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
15917399-5	2005	Depletion of PKC by phorbol-12-myristate-13-acetate (10 microM) blocked SP-induced IkappaBalpha and p65 phosphorylation and IL-8 production.	Tetradecanoylphorbol Acetate	20-51	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
15917399-6	2005	The PKCdelta inhibitor rottlerin at a low concentration (1 microM), but not pseudosubstrate PKC and PKCepsilon inhibitors (10 microM), significantly reduced IL-8 secretion.	rottlerin	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
15917399-8	2005	Moreover, overexpression of wild-type PKCdelta increased SP-induced IL-8 promoter- and NF-kappaB-driven luciferase activities that were rottlerin-sensitive.	rottlerin	136-145	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
15914040-9	2005	Both normal-TCs and PE-TCs produced more IL-6 and IL-8 when they were cultured under hypoxic conditions.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
15914040-9	2005	Both normal-TCs and PE-TCs produced more IL-6 and IL-8 when they were cultured under hypoxic conditions.	pe	20-22	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
15914040-9	2005	Both normal-TCs and PE-TCs produced more IL-6 and IL-8 when they were cultured under hypoxic conditions.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
16148071-0	2005	Resuscitation of hypoxic piglets with 100% O2 increases pulmonary metalloproteinases and IL-8.	Oxygen	43-45	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
16148071-12	2005	Moreover, IL-8 concentration increased significantly in piglets that were resuscitated with 100% O2 compared with 21% O2, suggesting a marked proinflammatory response in the pulmonary tissue.	Oxygen	97-99	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
16148071-12	2005	Moreover, IL-8 concentration increased significantly in piglets that were resuscitated with 100% O2 compared with 21% O2, suggesting a marked proinflammatory response in the pulmonary tissue.	Oxygen	118-120	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
16321206-11	2005	CONCLUSION: Mechanical stress induces the RPE cells to express MCP-1 and IL-8, and this effect was inhibited in part by pretreatment of CD, indicating that the cytoskeleton may be involved in the effect and that these two inflammatory cytokines take a part in the early stage of development of primary retinal detachment.	Cytochalasin D	136-138	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
16107255-0	2005	Histidine inhibits oxidative stress- and TNF-alpha-induced interleukin-8 secretion in intestinal epithelial cells.	Histidine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	59-72
16107255-1	2005	We investigated the effect of several amino acids on the secretion of such inflammatory cytokines as interleukin-8 (IL-8) induced by hydrogen peroxide or tumor necrosis factor-alpha (TNF-alpha) in intestinal epithelial-like Caco-2 and HT-29 cells.	Hydrogen Peroxide	133-150	C-X-C motif chemokine ligand 8	Homo sapiens	101-114
16107255-1	2005	We investigated the effect of several amino acids on the secretion of such inflammatory cytokines as interleukin-8 (IL-8) induced by hydrogen peroxide or tumor necrosis factor-alpha (TNF-alpha) in intestinal epithelial-like Caco-2 and HT-29 cells.	Hydrogen Peroxide	133-150	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
16107255-2	2005	We found that histidine, one of the conditionally essential amino acids, significantly inhibited both hydrogen peroxide- and TNF-alpha-induced IL-8 secretion and mRNA expression in Caco-2 cells and HT-29 cells.	Histidine	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
16107255-2	2005	We found that histidine, one of the conditionally essential amino acids, significantly inhibited both hydrogen peroxide- and TNF-alpha-induced IL-8 secretion and mRNA expression in Caco-2 cells and HT-29 cells.	Amino Acids, Essential	50-71	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
16107255-2	2005	We found that histidine, one of the conditionally essential amino acids, significantly inhibited both hydrogen peroxide- and TNF-alpha-induced IL-8 secretion and mRNA expression in Caco-2 cells and HT-29 cells.	Hydrogen Peroxide	102-119	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
16107255-3	2005	These inhibitions were dose dependent and the inhibition rate of hydrogen peroxide-induced IL-8 secretion reached more than 50% at a concentration of 25mM, with over 95% inhibition at a concentration of 50mM.	Hydrogen Peroxide	65-82	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
16107255-4	2005	TNF-alpha increased the transcriptional activity of the IL-8 promoter which was significantly inhibited by treating Caco-2 cells with histidine.	Histidine	134-143	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
16107255-5	2005	Histidine also abolished the NF-kappaB-dependent activation of the IL-8 promoter induced by TNF-alpha.	Histidine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
16107255-6	2005	These results indicate that histidine inhibited the hydrogen peroxide- and TNF-alpha-induced IL-8 secretion at the transcriptional level in intestinal epithelial cells, suggesting that histidine has the potential to attenuate intestinal inflammation.	Histidine	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
16107255-6	2005	These results indicate that histidine inhibited the hydrogen peroxide- and TNF-alpha-induced IL-8 secretion at the transcriptional level in intestinal epithelial cells, suggesting that histidine has the potential to attenuate intestinal inflammation.	Hydrogen Peroxide	52-69	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
16107255-6	2005	These results indicate that histidine inhibited the hydrogen peroxide- and TNF-alpha-induced IL-8 secretion at the transcriptional level in intestinal epithelial cells, suggesting that histidine has the potential to attenuate intestinal inflammation.	Histidine	185-194	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
16321207-12	2005	The concentrations of IL-8 in the supernatant of the culture fluid of THEC cells increased along with the time of stimulation of LPS and Poly: C, ligands for TLR3 and 4, and reached to 297.33 pg/ml and 229.67 pg/ml respectively 8 hours after, 10 times and 7 times those of the control group (both P &lt; 0.05).	Poly C	137-144	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
15993849-3	2005	Exposure of A549 to ethanol (0.1-1%) dose-dependently inhibited (by 15-49%) the release of G-CSF and IL-8, but not of M-CSF, triggered by IL1beta or TNFalpha.	Ethanol	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
16106104-10	2005	This is the first study demonstrating strong impact of VAD treatment on circulating mediators of sIL-2R and IL-8 levels parameters.	vad	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
16034135-3	2005	We have previously demonstrated that heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) decreases proinflammatory cytokine IL-8 and NO production in cytokine-stimulated intestinal epithelial cells by interfering with the NF-kappaB signaling pathway.	Heparin	37-44	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
16091628-1	2005	TIA-1 related protein binds avidly to uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes, including interleukin (IL)-8 and vascular endothelial growth factor (VEGF).	Uridine	38-45	C-X-C motif chemokine ligand 8	Homo sapiens	118-136
15805230-5	2005	DMOG significantly attenuated cytokine-induced IL-8 promoter activity and protein secretion and cytokine-induced PMN migration across human microvascular endothelial cell line HMEC-1 monolayers.	oxalylglycine	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
15805230-7	2005	In DMOG-pretreated (20 mg/kg) animals, plasma IL-8 levels at 3 h after onset of reperfusion were 405 +/- 40 pg/ml vs. 790 +/- 40 pg/ml in saline-treated ischemia-reperfusion animals (P &lt; 0.001).	oxalylglycine	3-7	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
15805230-7	2005	In DMOG-pretreated (20 mg/kg) animals, plasma IL-8 levels at 3 h after onset of reperfusion were 405 +/- 40 pg/ml vs. 790 +/- 40 pg/ml in saline-treated ischemia-reperfusion animals (P &lt; 0.001).	Sodium Chloride	138-144	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
15805230-9	2005	Both in vitro and in vivo DMOG-attenuated IL-8 production was associated with robust HO-1 expression.	oxalylglycine	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
16048981-0	2005	Nystatin induces secretion of interleukin (IL)-1beta, IL-8, and tumor necrosis factor alpha by a toll-like receptor-dependent mechanism.	Nystatin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
16048981-2	2005	Herein, we demonstrate that nystatin induces interleukin (IL)-1beta, IL-8, and tumor necrosis factor alpha secretion through its activation of toll-like receptor 1 (TLR1) and TLR2.	Nystatin	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
15963954-0	2005	Amphiphilic pyridinium salts block TNF alpha/NF kappa B signaling and constitutive hypersecretion of interleukin-8 (IL-8) from cystic fibrosis lung epithelial cells.	pyridinium salts	12-28	C-X-C motif chemokine ligand 8	Homo sapiens	101-114
15963954-0	2005	Amphiphilic pyridinium salts block TNF alpha/NF kappa B signaling and constitutive hypersecretion of interleukin-8 (IL-8) from cystic fibrosis lung epithelial cells.	pyridinium salts	12-28	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
15963954-3	2005	In a systematic search for candidate drugs that might be used therapeutically to suppress IL-8 secretion from these cells, we have identified a potent and efficacious series of amphiphilic pyridinium salts.	pyridinium salts	189-205	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
16011519-9	2005	Furthermore, BAY11-7082, an inhibitor of NF-kappaB activation, significantly reduced the IL-8 production, NF-kappaB binding activity and IkappaB-alpha degradation induced by V. vulnificus infection.	3-(4-methylphenylsulfonyl)-2-propenenitrile	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
15912140-6	2005	Release of IL-6, IL-8 and TNF-alpha was inhibited by 82-93% at 100 microM quercetin and kaempferol, and 31-70% by myricetin and morin.	Quercetin	74-83	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
15912140-6	2005	Release of IL-6, IL-8 and TNF-alpha was inhibited by 82-93% at 100 microM quercetin and kaempferol, and 31-70% by myricetin and morin.	kaempferol	88-98	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
15912140-6	2005	Release of IL-6, IL-8 and TNF-alpha was inhibited by 82-93% at 100 microM quercetin and kaempferol, and 31-70% by myricetin and morin.	myricetin	114-123	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
15997464-9	2005	Treatment with NS-398 severely diminished the IgE-dependently induced production of IL-8 and TNF-alpha.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	15-21	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
16029496-10	2005	The effects of CSE on IL-8 release were inhibited by glutathione (GSH) and associated with the induction of the oxidant sensing protein, heme oxygenase-1.	Glutathione	53-64	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
15943769-4	2005	The production of vascular endothelial growth factor (VEGF), interleukin (IL)-6 and IL-8 by HGF increased following stimulation with estradiol or progesterone, at concentrations comparable to those present in the plasma of pregnant women.	Estradiol	133-142	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
15943769-4	2005	The production of vascular endothelial growth factor (VEGF), interleukin (IL)-6 and IL-8 by HGF increased following stimulation with estradiol or progesterone, at concentrations comparable to those present in the plasma of pregnant women.	Progesterone	146-158	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
15961066-0	2005	Irsogladine maleate influences the response of gap junctional intercellular communication and IL-8 of human gingival epithelial cells following periodontopathogenic bacterial challenge.	irsogladine	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
16085794-7	2005	The augmented IL-8 mRNA expression in cord blood was inhibited by actinomycin D but enhanced by cycloheximide, suggesting that IL-8 production is controlled by de novo transcriptional induction as well as posttranscriptional up-regulation of IL-8 by neonatal leukocytes, relating to the development of CLD.	Dactinomycin	66-79	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
16085794-7	2005	The augmented IL-8 mRNA expression in cord blood was inhibited by actinomycin D but enhanced by cycloheximide, suggesting that IL-8 production is controlled by de novo transcriptional induction as well as posttranscriptional up-regulation of IL-8 by neonatal leukocytes, relating to the development of CLD.	Cycloheximide	96-109	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
16085794-7	2005	The augmented IL-8 mRNA expression in cord blood was inhibited by actinomycin D but enhanced by cycloheximide, suggesting that IL-8 production is controlled by de novo transcriptional induction as well as posttranscriptional up-regulation of IL-8 by neonatal leukocytes, relating to the development of CLD.	Cycloheximide	96-109	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
16085794-7	2005	The augmented IL-8 mRNA expression in cord blood was inhibited by actinomycin D but enhanced by cycloheximide, suggesting that IL-8 production is controlled by de novo transcriptional induction as well as posttranscriptional up-regulation of IL-8 by neonatal leukocytes, relating to the development of CLD.	Cycloheximide	96-109	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
16029496-10	2005	The effects of CSE on IL-8 release were inhibited by glutathione (GSH) and associated with the induction of the oxidant sensing protein, heme oxygenase-1.	Glutathione	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
16029496-11	2005	CONCLUSION: Cigarette smoke may directly cause the release of IL-8 from HASMC, an effect enhanced by TNF-alpha which is overexpressed in COPD.	hasmc	72-77	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
15920037-8	2005	(4) The relevance of our findings to human disease was suggested by a TTA-mediated downregulation of serum levels of soluble VCAM-1 and IL-8 in psoriasis patients.	1-(carboxymethylthio)tetradecane	70-73	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
15728708-6	2005	LPA also induced interleukin-8 (IL-8) synthesis in the colon cancer cells by primarily activating LPA2 receptor.	lysophosphatidic acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	17-30
15728708-6	2005	LPA also induced interleukin-8 (IL-8) synthesis in the colon cancer cells by primarily activating LPA2 receptor.	lysophosphatidic acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
16098254-0	2005	Gene polymorphisms of epidermal growth factor receptor and its downstream effector, interleukin-8, predict oxaliplatin efficacy in patients with advanced colorectal cancer.	Oxaliplatin	107-118	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
15958071-6	2005	The IL-8 secretion was inhibited by heat shock and butyrate concentrations as low as 0.2 m M for crypt-like and 1 m M for villous-like cells.	Butyrates	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
15958071-7	2005	In a dose-dependent manner, higher butyrate concentrations enhanced IL-8 secretion to maximal levels followed by a gradual but stable decline.	Butyrates	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
15958071-11	2005	We conclude that heat shock and low concentrations of butyrate inhibit IL-8 production by Caco-2 cells exposed to S. serovar Enteritidis.	Butyrates	54-62	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
15972489-8	2005	Exogenous PGE2 was able to induce interleukin-8 release in HeLa 229 epithelial cells.	Dinoprostone	10-14	C-X-C motif chemokine ligand 8	Homo sapiens	34-47
15994397-6	2005	In contrast with both control groups, surfactant-depleted animals challenged with GBS and conventional ventilation showed high levels of interleukin (IL)-8, tumour necrosis factor (TNF)-alpha and myeloperoxidase in bronchoalveolar lavage fluid after 5 h of ventilation.	gbs	82-85	C-X-C motif chemokine ligand 8	Homo sapiens	137-155
16273761-0	2005	Behcet"s disease patients present high levels of deglycosylated anti-lipoteichoic acid IgG and high IL-8 production after lipoteichoic acid stimulation.	lipoteichoic acid	122-139	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
15922727-3	2005	Single substitution of Cys residues present in the three extracellular loops (C119L, C196L, C286S) or in the seventh-transmembrane (TM) domain (C308L) abolished CXCL8 agonist binding, while no Cys substitution abolished surface receptor expression.	Cysteine	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	161-166
15922727-7	2005	We also show that every Cys substitution in CXCR2, including those that still bind CXCL8, results in an impairment of receptor activity, analyzed as cell chemotaxis and intracellular signaling, suggesting that some structural requirement is likely fulfilled by Cys presence.	Cysteine	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	83-88
15922727-7	2005	We also show that every Cys substitution in CXCR2, including those that still bind CXCL8, results in an impairment of receptor activity, analyzed as cell chemotaxis and intracellular signaling, suggesting that some structural requirement is likely fulfilled by Cys presence.	Cysteine	261-264	C-X-C motif chemokine ligand 8	Homo sapiens	83-88
15972489-9	2005	Finally, we demonstrated that interleukin-8 induction by Chlamydia infection or PGE2 treatment was dependent on extracellular signal-regulated kinase/mitogen-activated protein activity.	Dinoprostone	80-84	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
16091123-2	2005	This study aimed to examine the signal pathway in the production of cytokines [interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha)] by ROS generated from phorbol myristate acetate (PMA)-stimulated human mast cell line-1 cells (HMC-1).	Reactive Oxygen Species	149-152	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
15980221-6	2005	RESULTS: Both triptolide and dexamethasone inhibited in a dose-dependent manner the expression of IL-8 and MCP-1 in corneal fibroblasts induced by the proinflammatory cytokines IL-1beta or tumor necrosis factor (TNF)-alpha.	triptolide	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
15980221-6	2005	RESULTS: Both triptolide and dexamethasone inhibited in a dose-dependent manner the expression of IL-8 and MCP-1 in corneal fibroblasts induced by the proinflammatory cytokines IL-1beta or tumor necrosis factor (TNF)-alpha.	Dexamethasone	29-42	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
15980221-10	2005	CONCLUSIONS: Like dexamethasone, triptolide inhibited IL-8 and MCP-1 expression in cultured human corneal fibroblasts exposed to proinflammatory cytokines, an action most likely mediated by inhibition of NF-kappaB activation.	triptolide	33-43	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
15927671-1	2005	We previously reported the induction of interleukin-8 (IL-8), one of the CXC chemokines, by all-trans retinoic acid (ATRA) in PL-21 and NB4 human myeloid leukemia cells, which may be implicated in APL differentiation syndrome that is a relatively frequent complication in patients with acute promyelocytic leukemia (APL) during treatment with ATRA.	Tretinoin	102-115	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
15927671-1	2005	We previously reported the induction of interleukin-8 (IL-8), one of the CXC chemokines, by all-trans retinoic acid (ATRA) in PL-21 and NB4 human myeloid leukemia cells, which may be implicated in APL differentiation syndrome that is a relatively frequent complication in patients with acute promyelocytic leukemia (APL) during treatment with ATRA.	Tretinoin	102-115	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
15927671-1	2005	We previously reported the induction of interleukin-8 (IL-8), one of the CXC chemokines, by all-trans retinoic acid (ATRA) in PL-21 and NB4 human myeloid leukemia cells, which may be implicated in APL differentiation syndrome that is a relatively frequent complication in patients with acute promyelocytic leukemia (APL) during treatment with ATRA.	Tretinoin	117-121	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
15927671-1	2005	We previously reported the induction of interleukin-8 (IL-8), one of the CXC chemokines, by all-trans retinoic acid (ATRA) in PL-21 and NB4 human myeloid leukemia cells, which may be implicated in APL differentiation syndrome that is a relatively frequent complication in patients with acute promyelocytic leukemia (APL) during treatment with ATRA.	Tretinoin	117-121	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
15927671-1	2005	We previously reported the induction of interleukin-8 (IL-8), one of the CXC chemokines, by all-trans retinoic acid (ATRA) in PL-21 and NB4 human myeloid leukemia cells, which may be implicated in APL differentiation syndrome that is a relatively frequent complication in patients with acute promyelocytic leukemia (APL) during treatment with ATRA.	Tretinoin	343-347	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
15927671-1	2005	We previously reported the induction of interleukin-8 (IL-8), one of the CXC chemokines, by all-trans retinoic acid (ATRA) in PL-21 and NB4 human myeloid leukemia cells, which may be implicated in APL differentiation syndrome that is a relatively frequent complication in patients with acute promyelocytic leukemia (APL) during treatment with ATRA.	Tretinoin	343-347	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
15927671-5	2005	APL cells prepared from two APL patients showed gene expression of chemokines, such as IL-8, MCP-1, MIP-1alpha, and MIP-1beta when stimulated with ATRA in vitro.	Tretinoin	147-151	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
15927671-6	2005	Furthermore, serum levels of IL-8, MIP-1beta and RANTES were increased during the course of ATRA treatment in both APL patients who developed APL differentiation syndrome.	Tretinoin	92-96	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
16444871-9	2005	Exogenous ADMA also stimulated secretion of monocyte chemotactic protein-1 and interleukin-8.	N,N-dimethylarginine	10-14	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
15955209-9	2005	Therapeutic administration of sulfasalazine effectively downregulated the activation of NF-kappaB and the expression of IL-1beta mRNA and IL-8 mRNA while IkappaBalpha levels were stable.	Sulfasalazine	30-43	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
15982617-8	2005	Using SB203580, a specific inhibitor of p38 MAPK, we detected a concentration-dependent inhibition of IL-17--induced IL-8 production with a maximal decrease of 63 +/- 5% (n=8, p&lt;0.01).	SB 203580	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
15982617-9	2005	Curcumin, a specific inhibitor of JNK, also concentration-dependently reduced IL-17--induced IL-8 production, with a maximal decrease of 82+/-4% (n=8, p&lt;0.01).	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
15982617-11	2005	Pyrrolydine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, caused a 70+/-5% (n=8, p&lt;0.01) decrease in IL-17--induced IL-8 production.	pyrrolydine dithiocarbamate	0-27	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
15982617-11	2005	Pyrrolydine dithiocarbamate (PDTC), an inhibitor of NF-kappaB, caused a 70+/-5% (n=8, p&lt;0.01) decrease in IL-17--induced IL-8 production.	prolinedithiocarbamate	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
15982617-13	2005	We also found that p38MAPK, JNK, p42/p44 ERK and NF-kappaB play an important role in IL-17--induced IL-8 production in HASMC in vitro.	hasmc	119-124	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
15821150-5	2005	At low concentrations (&lt;0.1 microM), 15d-PGJ(2) inhibited IL-1beta-stimulated prostaglandin E(2) (PGE(2)) but not cytokine (IL-6/IL-8) production or cyclooxygenase-2 (COX-2) expression.	15d-pgj	40-47	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
16091123-2	2005	This study aimed to examine the signal pathway in the production of cytokines [interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha)] by ROS generated from phorbol myristate acetate (PMA)-stimulated human mast cell line-1 cells (HMC-1).	Reactive Oxygen Species	149-152	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
16091123-2	2005	This study aimed to examine the signal pathway in the production of cytokines [interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha)] by ROS generated from phorbol myristate acetate (PMA)-stimulated human mast cell line-1 cells (HMC-1).	Tetradecanoylphorbol Acetate	168-193	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
16091123-2	2005	This study aimed to examine the signal pathway in the production of cytokines [interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha)] by ROS generated from phorbol myristate acetate (PMA)-stimulated human mast cell line-1 cells (HMC-1).	Tetradecanoylphorbol Acetate	168-193	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
16091123-2	2005	This study aimed to examine the signal pathway in the production of cytokines [interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha)] by ROS generated from phorbol myristate acetate (PMA)-stimulated human mast cell line-1 cells (HMC-1).	Tetradecanoylphorbol Acetate	195-198	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
16091123-2	2005	This study aimed to examine the signal pathway in the production of cytokines [interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha)] by ROS generated from phorbol myristate acetate (PMA)-stimulated human mast cell line-1 cells (HMC-1).	Tetradecanoylphorbol Acetate	195-198	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
15701058-8	2005	The expression of IL-8 mRNA was increased in a dose-dependent manner after stimulation with CRP (1-100 microg/ml), whereas expression of IL-8 mRNA induced by CRP (50 microg/ml) was significantly diminished by 5 microM pitavastatin.	pitavastatin	218-230	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
15746434-3	2005	We found that the IL-8 mRNA expression in lung cancer cells significantly increased after coculture with phorbol myristate acetate-treated THP-1 cells and human primary lung macrophages.	Tetradecanoylphorbol Acetate	105-130	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
15746434-5	2005	The addition of anti-inflammatory agents pyrrolidine dithiocarbamate, pentoxifylline, aspirin, and dexamethasone could completely suppress the expression of IL-8 mRNA in fresh/sensitized lung cancer cell cocultures.	pyrrolidine dithiocarbamic acid	41-68	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
15746434-5	2005	The addition of anti-inflammatory agents pyrrolidine dithiocarbamate, pentoxifylline, aspirin, and dexamethasone could completely suppress the expression of IL-8 mRNA in fresh/sensitized lung cancer cell cocultures.	Pentoxifylline	70-84	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
15746434-5	2005	The addition of anti-inflammatory agents pyrrolidine dithiocarbamate, pentoxifylline, aspirin, and dexamethasone could completely suppress the expression of IL-8 mRNA in fresh/sensitized lung cancer cell cocultures.	Aspirin	86-93	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
15746434-5	2005	The addition of anti-inflammatory agents pyrrolidine dithiocarbamate, pentoxifylline, aspirin, and dexamethasone could completely suppress the expression of IL-8 mRNA in fresh/sensitized lung cancer cell cocultures.	Dexamethasone	99-112	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
15948980-8	2005	In some OLP patients with the serum IL-6 or IL-8 levels higher than the upper limit of normal serum concentration, treatment with levamisole for a period of 0.5-6.0 months could significantly reduce the mean serum IL-6 level from 14.3 +/- 1.9 pg mL(-1) to 3.2 +/- 0.6 pg mL(-1) (P &lt; 0.001) and could significantly reduce the mean serum IL-8 level from 95.8 +/- 17.1 pg mL(-1) to 14.8 +/- 5.8 pg mL(-1) (P &lt; 0.001).	Levamisole	130-140	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
15948980-8	2005	In some OLP patients with the serum IL-6 or IL-8 levels higher than the upper limit of normal serum concentration, treatment with levamisole for a period of 0.5-6.0 months could significantly reduce the mean serum IL-6 level from 14.3 +/- 1.9 pg mL(-1) to 3.2 +/- 0.6 pg mL(-1) (P &lt; 0.001) and could significantly reduce the mean serum IL-8 level from 95.8 +/- 17.1 pg mL(-1) to 14.8 +/- 5.8 pg mL(-1) (P &lt; 0.001).	Levamisole	130-140	C-X-C motif chemokine ligand 8	Homo sapiens	339-343
15948980-10	2005	Levamisole can modulate both the serum IL-6 and IL-8 levels in OLP patients.	Levamisole	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
15948980-11	2005	IL-8, like IL-6, is also a useful serum marker in evaluating the therapeutic effects of levamisole on OLP patients.	Levamisole	88-98	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15974585-3	2005	(R)-Ketoprofen (1) was previously reported to be a potent and specific noncompetitive inhibitor of CXCL8-induced human PMNs chemotaxis.	Ketoprofen	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	99-104
15862344-0	2005	Interleukin-8 primes oxidative burst in neutrophil-like HL-60 through changes in cytosolic calcium.	Calcium	91-98	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
15862344-3	2005	Proinflammatory cytokines such as interleukin-8 (IL-8) may modulate ROS generation through a priming phenomenon.	Reactive Oxygen Species	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	34-47
15862344-3	2005	Proinflammatory cytokines such as interleukin-8 (IL-8) may modulate ROS generation through a priming phenomenon.	Reactive Oxygen Species	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
15862344-4	2005	The aim of this study was to determine the effect of human IL-8 on ROS production in neutrophil-like dimethylsulfoxide-differentiated HL-60 cells (not equalHL-60 cells) and further to examine the role of Ca(2+) mobilization during the priming.	Reactive Oxygen Species	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
15862344-4	2005	The aim of this study was to determine the effect of human IL-8 on ROS production in neutrophil-like dimethylsulfoxide-differentiated HL-60 cells (not equalHL-60 cells) and further to examine the role of Ca(2+) mobilization during the priming.	Dimethyl Sulfoxide	101-118	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
15862344-5	2005	IL-8 at 10 nM induced no ROS production but a [Ca(2+)](i) rise (254 +/- 36 nM).	Reactive Oxygen Species	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15862344-6	2005	IL-8 induced a strongly enhanced (2 fold) ROS release during stimulation with 1 microM of N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLF).	Reactive Oxygen Species	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15862344-6	2005	IL-8 induced a strongly enhanced (2 fold) ROS release during stimulation with 1 microM of N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLF).	N-Formylmethionine Leucyl-Phenylalanine	90-135	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15862344-6	2005	IL-8 induced a strongly enhanced (2 fold) ROS release during stimulation with 1 microM of N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLF).	N-Formylmethionine Leucyl-Phenylalanine	137-141	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15893694-6	2005	Furthermore, IL-17 induction of CXCL-8 mRNA and protein release from ASM cells was abrogated by transcriptional inhibitor actinomycin D.	Dactinomycin	122-135	C-X-C motif chemokine ligand 8	Homo sapiens	32-38
15701058-0	2005	Inhibitory effect of pitavastatin (NK-104) on the C-reactive-protein-induced interleukin-8 production in human aortic endothelial cells.	pitavastatin	21-33	C-X-C motif chemokine ligand 8	Homo sapiens	77-90
15701058-0	2005	Inhibitory effect of pitavastatin (NK-104) on the C-reactive-protein-induced interleukin-8 production in human aortic endothelial cells.	pitavastatin	35-41	C-X-C motif chemokine ligand 8	Homo sapiens	77-90
15701058-3	2005	In the present study, we examined the effect of pitavastatin (NK-104), a synthetic statin (3-hydroxy-3-methylglutaryl CoA reductase inhibitor), on IL-8 production induced by CRP in human AoEC (aortic endothelial cells).	pitavastatin	48-60	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
15701058-3	2005	In the present study, we examined the effect of pitavastatin (NK-104), a synthetic statin (3-hydroxy-3-methylglutaryl CoA reductase inhibitor), on IL-8 production induced by CRP in human AoEC (aortic endothelial cells).	pitavastatin	62-68	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
15701058-7	2005	The production of IL-8 induced by CRP (10 microg/ml) was enhanced significantly and was inhibited by pitavastatin.	pitavastatin	101-113	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
15701058-8	2005	The expression of IL-8 mRNA was increased in a dose-dependent manner after stimulation with CRP (1-100 microg/ml), whereas expression of IL-8 mRNA induced by CRP (50 microg/ml) was significantly diminished by 5 microM pitavastatin.	pitavastatin	218-230	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
15701058-9	2005	Furthermore, specific MAPK inhibitors (PD98059, SB203580 and SP600125) inhibited the expression of IL-8 mRNA induced by CRP (50 microg/ml).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	39-46	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
15701058-9	2005	Furthermore, specific MAPK inhibitors (PD98059, SB203580 and SP600125) inhibited the expression of IL-8 mRNA induced by CRP (50 microg/ml).	SB 203580	48-56	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
15701058-9	2005	Furthermore, specific MAPK inhibitors (PD98059, SB203580 and SP600125) inhibited the expression of IL-8 mRNA induced by CRP (50 microg/ml).	pyrazolanthrone	61-69	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
15701058-11	2005	Our results suggest that CRP may play a role in atherosclerosis via IL-8 production and pitavastatin may prevent the progression of atherosclerosis not only by lowering plasma low-density lipoprotein cholesterol levels, but also by suppressing IL-8 production in endothelial cells through the inhibition of MAPK (ERK, p38 MAPK and JNK) pathways.	pitavastatin	88-100	C-X-C motif chemokine ligand 8	Homo sapiens	244-248
15799714-4	2005	Kibayashi and co-workers in this issue of Clinical Science confirm that CRP induces IL-8 production in human aortic endothelial cells in vitro, via the activation of MAPKs (mitogen-activated protein kinases), an effect that can be inhibited by pitavastatin.	pitavastatin	244-256	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
15870903-0	2005	Inhibition of interleukin-8 production in the human colonic epithelial cell line HT-29 by 18 beta-glycyrrhetinic acid.	beta-glycyrrhetinic acid	93-117	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
15924880-5	2005	Sabaeksan (1 mg/ml) inhibited PMA plus A23187-induced TNF-alpha, IL-6, and IL-8 secretion by 43.86+/-5.26%, 56.39+/-3.65%, and 63.48+/-2.54%, respectively.	Calcimycin	39-45	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
15924880-5	2005	Sabaeksan (1 mg/ml) inhibited PMA plus A23187-induced TNF-alpha, IL-6, and IL-8 secretion by 43.86+/-5.26%, 56.39+/-3.65%, and 63.48+/-2.54%, respectively.	sabaeksan	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
15870903-3	2005	We investigated the role of 18 beta-glycyrrhetinic acid (GA), a saponin isolated from licorice roots, on TNF-alpha-induced IL-8 production in human colonic epithelial cells.	beta-glycyrrhetinic acid	31-55	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
15870903-3	2005	We investigated the role of 18 beta-glycyrrhetinic acid (GA), a saponin isolated from licorice roots, on TNF-alpha-induced IL-8 production in human colonic epithelial cells.	Gallium	57-59	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
15870903-6	2005	GA suppressed TNF-alpha-induced IL-8 production in a concentration-dependent manner.	Gallium	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
15870903-8	2005	These results suggest that GA has the inhibitory effects on TNF-alpha-induced IL-8 production in the intestinal epithelial cells through blockade in the phosphorylation of MAPKs, following I kappa B alpha degradation and NF-kappa B activation.	Gallium	27-29	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	phenylalanylleucine	25-32	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	phenylalanylleucine	25-32	C-X-C motif chemokine ligand 8	Homo sapiens	212-216
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Serine	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Serine	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	212-216
15755849-2	2005	The expression of the prostaglandin synthetic enzyme cyclooxygenase (COX)-2 and cytokines IL-1beta and IL-8 increases within the uterus at the time of labor, and each is regulated by the transcription factor nuclear factor-kappaB (NF-kappaB).	Prostaglandins	22-35	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Leucine	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Leucine	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	212-216
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Arginine	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Aspartic Acid	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Aspartic Acid	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	212-216
15755869-5	2005	The addition of thrombin inhibitor d-phenylalanyl-l-prolyl-l arginine chloromethyl ketone (PPACK) together with thrombin inhibited the thrombin-induced secretion of IL-8 and MCP-1.	d-phenylalanyl-l-prolyl-l arginine chloromethyl ketone	35-89	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
15955105-10	2005	Topical application of calcipotriol to lesional psoriatic skin for 4 d resulted in increased NF-kappaB binding to the p53 kappaB site and decreased NF-kappaB binding to the IL-8 kappaB site.	calcipotriene	23-35	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
15956258-4	2005	Parthenolide was effective either alone or in combination with docetaxel in reducing colony formation, inducing apoptosis and reducing the expression of prometastatic genes IL-8 and the antiapoptotic gene GADD45beta1 in vitro.	Docetaxel	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
15956258-4	2005	Parthenolide was effective either alone or in combination with docetaxel in reducing colony formation, inducing apoptosis and reducing the expression of prometastatic genes IL-8 and the antiapoptotic gene GADD45beta1 in vitro.	parthenolide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
16032878-1	2005	We report an experimental study of the variation of surface stress with surface charge density for nanoporous Pt immersed in aqueous solutions of NaF of various concentration.	Platinum	110-112	C-X-C motif chemokine ligand 8	Homo sapiens	146-149
15845391-4	2005	Stimulation with polyI:C elicited the elevated production and mRNA expression of IL-6 and IL-8 in HCEC.	Poly I-C	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
15855050-6	2005	The early loss of ascorbate correlated with duration of CPB (P &lt; 0.002, r = 0.72), plasma hemoglobin after cross-clamp removal (P &lt; 0.001, r = 0.70), and IL-6 and IL-8 levels at 24 and 48 h after CPB (P &lt; 0.01), but not with postoperative lactate levels, strongly suggesting that hemolysis, and not inflammation or ischemia, was the main cause of early oxidative stress.	Ascorbic Acid	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
15879132-3	2005	Accordingly, we observed that synthetic dsRNA, polyinosinic acid:cytidylic acid (poly(I:C)), potently induced gene remodeling in model intestinal epithelia with the specific pattern of expressed genes, including both classic proinflammatory genes (e.g., IL-8), as well as genes that are classically activated in virus-infected cells (e.g., IFN-responsive genes).	Poly I	47-64	C-X-C motif chemokine ligand 8	Homo sapiens	254-258
15879132-3	2005	Accordingly, we observed that synthetic dsRNA, polyinosinic acid:cytidylic acid (poly(I:C)), potently induced gene remodeling in model intestinal epithelia with the specific pattern of expressed genes, including both classic proinflammatory genes (e.g., IL-8), as well as genes that are classically activated in virus-infected cells (e.g., IFN-responsive genes).	Cytidine Monophosphate	65-79	C-X-C motif chemokine ligand 8	Homo sapiens	254-258
15879132-3	2005	Accordingly, we observed that synthetic dsRNA, polyinosinic acid:cytidylic acid (poly(I:C)), potently induced gene remodeling in model intestinal epithelia with the specific pattern of expressed genes, including both classic proinflammatory genes (e.g., IL-8), as well as genes that are classically activated in virus-infected cells (e.g., IFN-responsive genes).	poly	47-51	C-X-C motif chemokine ligand 8	Homo sapiens	254-258
15879132-4	2005	Poly(I:C)-induced IL-8 was concentration dependent (2-100 mug/ml) and displayed slower kinetics compared with IL-8 induced by bacterial flagellin (ET(50) approximately 24 vs 8 h poly(I:C) vs flagellin, respectively).	Poly I-C	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
16032847-1	2005	DMPC vesicles were injected into a 50 mM NaF solution in water, and the kinetics of a monolayer formation at the air-solution interface was investigated by measuring changes of the film pressure, pi, as a function of time.	Dimyristoylphosphatidylcholine	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
16045029-2	2005	METHODS: Immunohistochemical method of avidin-biotin complex was used for microvessel counts on the routinely formalin-fixed and paraffin-embedded sections of specimens of hypertrophic scars, keloids, normal skin, and surgical scar, and in situ hybridization for the expressions of IL-8, MCP-1, MIP-1alpha mRNA.	avidin-biotin	39-52	C-X-C motif chemokine ligand 8	Homo sapiens	282-286
15746099-8	2005	The BK-triggered increased IL-8 secretion in SMM-treated cultures was mediated by an increased Ca(2+)(i) mobilization consequent to an ER expansion associated with increases in protein synthesis (total, cytokines, and antimicrobial factors).	smm	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
15796906-2	2005	Recently, the hP2Y6 receptor has been reported to mediate monocyte IL-8 production in response to UDP or lipopolysaccharide (LPS), but the role of hP2Y6 in regulating other pro-inflammatory cytokines or mediators is largely unknown.	Uridine Diphosphate	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
15796906-3	2005	We demonstrate here that UDP specifically induces soluble TNF-alpha and IL-8 production in a promonocytic U937 cell line stably transfected with hP2Y6.	Uridine Diphosphate	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
15796906-6	2005	Interestingly, UDP induces the production of IL-8, but not TNF-alpha, in human astrocytoma 1321N1 cell lines stably transfected with hP2Y6.	Uridine Diphosphate	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
15796906-9	2005	From the Taqman analysis, UDP stimulation significantly upregulates the mRNA levels of IL-8, IP-10, and IL-1beta, but not TNF-alpha.	Uridine Diphosphate	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
15855488-6	2005	Indolicidin was analogous to LL-37 in its ability to induce the production of the chemokine interleukin-8 (IL-8) in a human bronchial cell line, 16HBE14o(-), but it was unable to induce production of IL-8 in THP-1 cells.	16hbe14o	145-153	C-X-C motif chemokine ligand 8	Homo sapiens	92-105
15845704-7	2005	We also analyzed the effect of NAC on interleukin-8 (IL-8)-induced expression of CD11b in human whole blood.	Acetylcysteine	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	38-51
15845704-7	2005	We also analyzed the effect of NAC on interleukin-8 (IL-8)-induced expression of CD11b in human whole blood.	Acetylcysteine	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
15845704-8	2005	IL-8 (10 ng/mL) significantly upregulated the expression of CD11b, and the IL-8-induced upregulation was significantly attenuated by NAC (&gt;10 mM) in a dose-dependent manner.	Acetylcysteine	133-136	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15845704-8	2005	IL-8 (10 ng/mL) significantly upregulated the expression of CD11b, and the IL-8-induced upregulation was significantly attenuated by NAC (&gt;10 mM) in a dose-dependent manner.	Acetylcysteine	133-136	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
15845704-9	2005	We conclude that NAC attenuates the increased expression of CD11b in either LPS or IL-8-stimulated human whole blood.	Acetylcysteine	17-20	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
15855488-6	2005	Indolicidin was analogous to LL-37 in its ability to induce the production of the chemokine interleukin-8 (IL-8) in a human bronchial cell line, 16HBE14o(-), but it was unable to induce production of IL-8 in THP-1 cells.	16hbe14o	145-153	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
15807851-1	2005	This study was designed to investigate the relationship between influx of extracellular Ca(2+), activation of NFkappaB and synthesis of interleukin-8 (IL-8) following exposure of human neutrophils to subcytolytic concentrations (8.37 and 41.75 ng/ml) of the pneumococcal toxin, pneumolysin, as well as the potential of the omega-3 polyunsaturated fatty acid, docosahexaenoic acid, to antagonize these events.	omega-3 polyunsaturated fatty acid	323-357	C-X-C motif chemokine ligand 8	Homo sapiens	136-149
15826602-4	2005	Actinomcyin D markedly reduced the upregulation of IL-6 and IL-8 mRNA.	actinomcyin d	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
16161253-1	2005	We have previously reported that sodium fluoride (NaF) showed slightly higher cytotoxicity against human oral tumor cell lines than normal human oral cells.	Sodium Fluoride	33-48	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
15807851-1	2005	This study was designed to investigate the relationship between influx of extracellular Ca(2+), activation of NFkappaB and synthesis of interleukin-8 (IL-8) following exposure of human neutrophils to subcytolytic concentrations (8.37 and 41.75 ng/ml) of the pneumococcal toxin, pneumolysin, as well as the potential of the omega-3 polyunsaturated fatty acid, docosahexaenoic acid, to antagonize these events.	omega-3 polyunsaturated fatty acid	323-357	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
15807851-1	2005	This study was designed to investigate the relationship between influx of extracellular Ca(2+), activation of NFkappaB and synthesis of interleukin-8 (IL-8) following exposure of human neutrophils to subcytolytic concentrations (8.37 and 41.75 ng/ml) of the pneumococcal toxin, pneumolysin, as well as the potential of the omega-3 polyunsaturated fatty acid, docosahexaenoic acid, to antagonize these events.	Docosahexaenoic Acids	359-379	C-X-C motif chemokine ligand 8	Homo sapiens	136-149
15807851-1	2005	This study was designed to investigate the relationship between influx of extracellular Ca(2+), activation of NFkappaB and synthesis of interleukin-8 (IL-8) following exposure of human neutrophils to subcytolytic concentrations (8.37 and 41.75 ng/ml) of the pneumococcal toxin, pneumolysin, as well as the potential of the omega-3 polyunsaturated fatty acid, docosahexaenoic acid, to antagonize these events.	Docosahexaenoic Acids	359-379	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
15807851-5	2005	These observations demonstrate that activation of NFkappaB and synthesis of IL-8, following exposure of neutrophils to pneumolysin are dependent on toxin-mediated influx of Ca(2+) and that these potentially harmful activities of the toxin are antagonized by docosahexaenoic acid.	Docosahexaenoic Acids	258-278	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
15661856-6	2005	Transfection with either HO-1 small interfering RNA or HO-1 antisense oligodeoxynucleotide abrogated the ability of SNAP to induce HO-1 expression and IL-8 and VEGF productions.	Oligodeoxyribonucleotides	70-90	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
15661856-5	2005	The NO donor S-nitroso-N-acetyl-penicillamine (SNAP) dose-dependently increased IL-8 and VEGF productions and HO-1 expression in HUVECs.	S-Nitroso-N-Acetylpenicillamine	13-45	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
15863635-9	2005	Epithelial expression of interleukin-8 showed a tendency towards a significant increase after LPS compared to saline.	Sodium Chloride	110-116	C-X-C motif chemokine ligand 8	Homo sapiens	25-38
15661856-5	2005	The NO donor S-nitroso-N-acetyl-penicillamine (SNAP) dose-dependently increased IL-8 and VEGF productions and HO-1 expression in HUVECs.	S-Nitroso-N-Acetylpenicillamine	47-51	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
15827963-3	2005	We here demonstrate statistically significant synergy between regakine-1 and the neutrophil attractants C5a or IL-8/CXCL8 in inducing neutrophil shape change and migration under agarose.	Sepharose	178-185	C-X-C motif chemokine ligand 8	Homo sapiens	116-121
15829704-10	2005	Finally, pretreatment with AG-1478, the MEK inhibitor UO126, and NAC prevented the albumin-induced increase in IL-8 expression.	RTKI cpd	27-34	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
15845465-4	2005	Maximal production of IL-8 in response to Act required the presence of intracellular calcium, since chelation of calcium with BAPTA-AM significantly reduced Act-induced IL-8 production in HT-29 cells.	Calcium	85-92	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
15845465-4	2005	Maximal production of IL-8 in response to Act required the presence of intracellular calcium, since chelation of calcium with BAPTA-AM significantly reduced Act-induced IL-8 production in HT-29 cells.	Calcium	85-92	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
15845465-4	2005	Maximal production of IL-8 in response to Act required the presence of intracellular calcium, since chelation of calcium with BAPTA-AM significantly reduced Act-induced IL-8 production in HT-29 cells.	Calcium	113-120	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
15845465-4	2005	Maximal production of IL-8 in response to Act required the presence of intracellular calcium, since chelation of calcium with BAPTA-AM significantly reduced Act-induced IL-8 production in HT-29 cells.	Calcium	113-120	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
15845465-4	2005	Maximal production of IL-8 in response to Act required the presence of intracellular calcium, since chelation of calcium with BAPTA-AM significantly reduced Act-induced IL-8 production in HT-29 cells.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	126-134	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
15845465-4	2005	Maximal production of IL-8 in response to Act required the presence of intracellular calcium, since chelation of calcium with BAPTA-AM significantly reduced Act-induced IL-8 production in HT-29 cells.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	126-134	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
15866594-1	2005	OBJECTIVE: To investigate whether and how P, dienogest (synthetic progestin), and danazol affected tumor necrosis factor alpha (TNFalpha)-induced interleukin-8 (IL-8) expression in endometriotic stromal cells.	Danazol	82-89	C-X-C motif chemokine ligand 8	Homo sapiens	146-159
15866594-1	2005	OBJECTIVE: To investigate whether and how P, dienogest (synthetic progestin), and danazol affected tumor necrosis factor alpha (TNFalpha)-induced interleukin-8 (IL-8) expression in endometriotic stromal cells.	Danazol	82-89	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
15866594-10	2005	The up-regulation of the IL-8 gene and protein expression by TNFalpha and E2 was significantly reduced by the addition of P, dienogest, or danazol.	Danazol	139-146	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
15829704-10	2005	Finally, pretreatment with AG-1478, the MEK inhibitor UO126, and NAC prevented the albumin-induced increase in IL-8 expression.	U 0126	54-59	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
15687330-0	2005	Thalidomide inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in endometriotic stromal cells, possibly through suppression of nuclear factor-kappaB activation.	Thalidomide	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	57-70
15829704-10	2005	Finally, pretreatment with AG-1478, the MEK inhibitor UO126, and NAC prevented the albumin-induced increase in IL-8 expression.	Acetylcysteine	65-68	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
15779068-6	2005	Genistein, piceatannol, and TAS diminished secretion of TNF-alpha, and IL-8.	Genistein	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
15701708-7	2005	In addition, AGIX-4207 inhibited cytokine-induced levels of monocyte chemoattractant protein-1, interleukin (IL)-6, and IL-8 from endothelial cells and human fibroblast-like synoviocytes as well as lipopolysaccharide-induced release of TNF-alpha, IL-1beta, and IL-6 from human peripheral blood mononuclear cells.	camobucol	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
15829265-0	2005	Requirement of the extracellular cysteine at position six for CD40/CD40 dimer formation and CD40-induced IL-8 expression.	Cysteine	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
15829265-7	2005	Abolishment of disulfide-linked CD40/CD40 dimers in these transfected cells was sufficient to inhibit CD40-induced mRNA expression and secretion of IL-8.	Disulfides	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
15840782-6	2005	Exposure to NaF for 30 or 120 sec increased plaque fluoride concentrations near the saliva interface, while concentrations near the enamel surface remained low.	Fluorides	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
15840782-7	2005	Fluoride penetration increased with duration of NaF exposure.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
15840783-4	2005	The phenol-water extracts activated human gingival fibroblasts to mediate IL-8 production, as well as IL-8 mRNA expression, phosphorylation of p38 mitogen-activated protein kinase, and expression of intercellular adhesion molecule-1.	Phenol	4-10	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
15840783-4	2005	The phenol-water extracts activated human gingival fibroblasts to mediate IL-8 production, as well as IL-8 mRNA expression, phosphorylation of p38 mitogen-activated protein kinase, and expression of intercellular adhesion molecule-1.	Phenol	4-10	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
15840783-4	2005	The phenol-water extracts activated human gingival fibroblasts to mediate IL-8 production, as well as IL-8 mRNA expression, phosphorylation of p38 mitogen-activated protein kinase, and expression of intercellular adhesion molecule-1.	Water	11-16	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
15840783-4	2005	The phenol-water extracts activated human gingival fibroblasts to mediate IL-8 production, as well as IL-8 mRNA expression, phosphorylation of p38 mitogen-activated protein kinase, and expression of intercellular adhesion molecule-1.	Water	11-16	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
15867792-11	2005	Bile acids correlated with BALF IL-8 and alveolar neutrophilia (r = 0.3, P = .0004, and r = 0.3, P = .004, respectively), but not with IL-15.	Bile Acids and Salts	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
15867792-14	2005	Elevated BALF bile acids may promote early BOS development via an inflammatory process, possibly mediated by IL-8 and alveolar neutrophilia.	Bile Acids and Salts	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
15779068-6	2005	Genistein, piceatannol, and TAS diminished secretion of TNF-alpha, and IL-8.	3,3',4,5'-tetrahydroxystilbene	11-22	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
15779068-6	2005	Genistein, piceatannol, and TAS diminished secretion of TNF-alpha, and IL-8.	tas	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
15779068-7	2005	TAS reduced mRNA levels of COX-2, TNF-alpha, IL-8, IL-6, and IL-1alpha, while resveratrol impaired early expression of IL-8 and TNF-alpha.	tas	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
15862158-9	2005	Rolipram inhibited the expression of IL-8 mRNA and the activation of NF-kappaB(P&lt;0.05).	Rolipram	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
15779068-7	2005	TAS reduced mRNA levels of COX-2, TNF-alpha, IL-8, IL-6, and IL-1alpha, while resveratrol impaired early expression of IL-8 and TNF-alpha.	Resveratrol	78-89	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
15850408-4	2005	Pravastatin inhibited the overproduction of monocyte chemoattractant protein 1, IL6 and IL8 and the enhanced expression of intercellular adhesion molecule 1 but had no effect on platelet-endothelial cell adhesion molecule 1 expression.	Pravastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	88-91
15862158-10	2005	CONCLUSION: The results indicated that IL-8 mRNA may play a pathogenic role in the development of COPD and that selective PDE type IV inhibitor Rolipram inhibit the expression of IL-8 mRNA via NF-kappaB.	Rolipram	144-152	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
15877961-6	2005	CONCLUSION: Aloe polysaccharide could promote keratinocytes to secrete TGF-alpha, TGF-beta1, IL-1beta, IL-6, IL-8 and TNF, and inhibit the release of NO.	aloe polysaccharide	12-31	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
15659384-0	2005	Prostaglandin E2 induces interleukin-8 gene transcription by activating C/EBP homologous protein in human T lymphocytes.	Dinoprostone	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	25-38
15846428-1	2005	Probe beam deflection (PBD) and AC impedance are used to quantitatively evaluate the double layer properties of carbon aerogel electrodes in aqueous media (NaF).	Carbon	112-118	C-X-C motif chemokine ligand 8	Homo sapiens	156-159
15659384-3	2005	Several kinases, including protein kinase C, Src family tyrosine kinases, phosphatidylinositol 3-kinase, and p38 MAPK, were involved in PGE(2)-induced CHOP activation and IL-8 production.	Dinoprostone	136-142	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
15659384-1	2005	The effect of prostaglandin E(2) (PGE(2)) in regulating the synthesis of the pro-inflammatory chemokine interleukin-8 (IL-8) in T lymphocytes is not yet defined, even though it may reduce or enhance IL-8 synthesis in other cell types.	Dinoprostone	14-32	C-X-C motif chemokine ligand 8	Homo sapiens	104-117
15659384-5	2005	Our data suggest that PGE(2) acts as a potent pro-inflammatory mediator by inducing IL-8 gene transcription in activated T cells through different signal transduction pathways leading to CHOP activation.	Prostaglandins E	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
15659384-6	2005	These findings show the complexity with which PGE(2) regulates IL-8 synthesis by inhibiting or enhancing its production depending on the cell types and environmental conditions.	Prostaglandins E	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
15701651-7	2005	Finally, muramyl dipeptide induced interleukin-8 production in MAIL8 cells.	Acetylmuramyl-Alanyl-Isoglutamine	9-26	C-X-C motif chemokine ligand 8	Homo sapiens	35-48
15659384-1	2005	The effect of prostaglandin E(2) (PGE(2)) in regulating the synthesis of the pro-inflammatory chemokine interleukin-8 (IL-8) in T lymphocytes is not yet defined, even though it may reduce or enhance IL-8 synthesis in other cell types.	Dinoprostone	14-32	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
15659384-1	2005	The effect of prostaglandin E(2) (PGE(2)) in regulating the synthesis of the pro-inflammatory chemokine interleukin-8 (IL-8) in T lymphocytes is not yet defined, even though it may reduce or enhance IL-8 synthesis in other cell types.	Dinoprostone	34-40	C-X-C motif chemokine ligand 8	Homo sapiens	104-117
15659384-1	2005	The effect of prostaglandin E(2) (PGE(2)) in regulating the synthesis of the pro-inflammatory chemokine interleukin-8 (IL-8) in T lymphocytes is not yet defined, even though it may reduce or enhance IL-8 synthesis in other cell types.	Dinoprostone	34-40	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
15659384-1	2005	The effect of prostaglandin E(2) (PGE(2)) in regulating the synthesis of the pro-inflammatory chemokine interleukin-8 (IL-8) in T lymphocytes is not yet defined, even though it may reduce or enhance IL-8 synthesis in other cell types.	Dinoprostone	34-40	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
15659384-2	2005	Here, we demonstrate that, in human T cells, PGE(2) induced IL-8 mRNA transcription through prostaglandin E(2) receptors 1- and 4-dependent signal transduction pathways leading to the activation of the transcription factor C/EBP homologous protein (CHOP), never before implicated in IL-8 transcription.	Prostaglandins E	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
15659384-2	2005	Here, we demonstrate that, in human T cells, PGE(2) induced IL-8 mRNA transcription through prostaglandin E(2) receptors 1- and 4-dependent signal transduction pathways leading to the activation of the transcription factor C/EBP homologous protein (CHOP), never before implicated in IL-8 transcription.	Prostaglandins E	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	283-287
16061006-0	2005	[Effects of erythromycin on hydrogen peroxide-induced interleukin-8 synthesis and regulation of glutathione in human bronchial epithelial cells].	Erythromycin	12-24	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
16061006-0	2005	[Effects of erythromycin on hydrogen peroxide-induced interleukin-8 synthesis and regulation of glutathione in human bronchial epithelial cells].	Hydrogen Peroxide	28-45	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
16061006-1	2005	OBJECTIVE: To study the effects of erythromycin on Hydrogen peroxide (H2O2)-induced interleukin-8 synthesis and regulation of glutathione in human bronchial epithelial cells.	Erythromycin	35-47	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
16061006-1	2005	OBJECTIVE: To study the effects of erythromycin on Hydrogen peroxide (H2O2)-induced interleukin-8 synthesis and regulation of glutathione in human bronchial epithelial cells.	Hydrogen Peroxide	51-68	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
16061006-1	2005	OBJECTIVE: To study the effects of erythromycin on Hydrogen peroxide (H2O2)-induced interleukin-8 synthesis and regulation of glutathione in human bronchial epithelial cells.	Hydrogen Peroxide	70-74	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
16061006-8	2005	CONCLUSION: Erythromycin inhibits oxidant-mediated IL-8 levels through down-regulation of NF-kB and AP-1 binding in HBE, which can further influence the synthesis of GSH and expression gamma-GCS in HBE.	Erythromycin	12-24	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
15801837-1	2005	A novel class of 2-(R)-phenylpropionamides has been recently reported to inhibit in vitro and in vivo interleukin-8 (CXCL8)-induced biological activities.	2-(r)-phenylpropionamides	17-42	C-X-C motif chemokine ligand 8	Homo sapiens	102-115
15801837-2	2005	These CXCL8 inhibitors are derivatives of phenylpropionic nonsteroidal antiinflammatory drugs (NSAIDs), high-affinity ligands for site II of human serum albumin (HSA).	phenylpropionic	42-57	C-X-C motif chemokine ligand 8	Homo sapiens	6-11
16851713-1	2005	We present results from molecular dynamics simulation of aqueous solutions of alkali halide salts (NaI and NaF) at the interface with hydrophobic objects.	halide salts	85-97	C-X-C motif chemokine ligand 8	Homo sapiens	107-110
15801837-1	2005	A novel class of 2-(R)-phenylpropionamides has been recently reported to inhibit in vitro and in vivo interleukin-8 (CXCL8)-induced biological activities.	2-(r)-phenylpropionamides	17-42	C-X-C motif chemokine ligand 8	Homo sapiens	117-122
15777559-1	2005	Our previous study demonstrated that homocysteine (Hcy) mediated the expression and secretion of MCP-1 and IL-8 in human monocytes.	Homocysteine	37-49	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
15591095-7	2005	Inhibition of ERK MAPK pathway using U0126 prevented CRP-induced IL-8 upregulation, and Western blot analysis revealed a rapid activation of ERK1/2 after CRP stimulation.	U 0126	37-42	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
15777559-1	2005	Our previous study demonstrated that homocysteine (Hcy) mediated the expression and secretion of MCP-1 and IL-8 in human monocytes.	Homocysteine	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
15777559-5	2005	After patients with HHcy underwent low-dose folic acid treatment (0.8 mg/d) for 6 months, plasma Hcy levels were decreased and the hyper-responsiveness of MCP-1 and IL-8 secreted by isolated monocytes was significantly reversed.	Folic Acid	44-54	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
15777559-5	2005	After patients with HHcy underwent low-dose folic acid treatment (0.8 mg/d) for 6 months, plasma Hcy levels were decreased and the hyper-responsiveness of MCP-1 and IL-8 secreted by isolated monocytes was significantly reversed.	Homocysteine	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
15762874-7	2005	NNKOAc mimicked NNK effects, whereas NDMAOAc significantly inhibited IL-8 production in BEAS-2B cells and MCP-1 in both cell types.	methyl(acetoxymethyl)nitrosamine	37-44	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
15760459-0	2005	Mycobacterium bovis bacille Calmette Guerin infection of human neutrophils induces CXCL8 secretion by MyD88-dependent TLR2 and TLR4 activation.	guerin	37-43	C-X-C motif chemokine ligand 8	Homo sapiens	83-88
15825081-7	2005	RESULTS: TxB activates EGFR and ERK1/2 phosphorylation with subsequent release of IL-8 from human colonocytes.	(2s,3r,4r,5r)-5-Sulfanyloxane-2,3,4-Triol	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
15825081-11	2005	Inhibition of MMP, EGFR, and ERK activation significantly decreased TxB-induced IL-8 expression.	(2s,3r,4r,5r)-5-Sulfanyloxane-2,3,4-Triol	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
15825081-2	2005	In a xenograft animal model, TxB was shown to induce interleukin (IL)-8 gene expression in human colonic epithelium.	(2s,3r,4r,5r)-5-Sulfanyloxane-2,3,4-Triol	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	53-71
15664665-4	2005	The stimulatory effect of BK on the IL-1beta- or TNFalpha-stimulated IL-8 production was reduced in the presence of BK B2 receptor antagonist HOE 140, whereas the B1 receptor antagonist Lys-(des-arg9, Leu8)-BK had no effect.	des-arg9	191-199	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
15664665-6	2005	The protein kinase C (PKC) inhibitor bisindolylmaleimide, BIS, significantly reduced the stimulatory effect of BK on IL-1beta and TNFalpha increased IL-8 production but did not affect the production of IL-8 stimulated by cytokines alone.	bisindolylmaleimide	37-56	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
15856410-6	2005	Using a nuclear factor-kappaB (NF-kappaB) luciferase reporter assay system and Western analysis, we identified that magnolol and honokiol exert their anti-inflammatory effects by inhibiting the NF-kappaB element, which exists in Cox-2, IL-8, and TNF-alpha promoters [(15 microM magnolol: 44.8% inhibition), (15 microM honokiol: 42.3% inhibition)].	magnolol	116-124	C-X-C motif chemokine ligand 8	Homo sapiens	236-240
15856410-6	2005	Using a nuclear factor-kappaB (NF-kappaB) luciferase reporter assay system and Western analysis, we identified that magnolol and honokiol exert their anti-inflammatory effects by inhibiting the NF-kappaB element, which exists in Cox-2, IL-8, and TNF-alpha promoters [(15 microM magnolol: 44.8% inhibition), (15 microM honokiol: 42.3% inhibition)].	honokiol	129-137	C-X-C motif chemokine ligand 8	Homo sapiens	236-240
15664665-6	2005	The protein kinase C (PKC) inhibitor bisindolylmaleimide, BIS, significantly reduced the stimulatory effect of BK on IL-1beta and TNFalpha increased IL-8 production but did not affect the production of IL-8 stimulated by cytokines alone.	Bismuth	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
15664665-5	2005	Similar to BK, the calcium ionophore A23187 also upregulated the stimulatory effect of IL-1beta and TNFalpha on IL-8 production.	Calcium	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
15664665-6	2005	The protein kinase C (PKC) inhibitor bisindolylmaleimide, BIS, significantly reduced the stimulatory effect of BK on IL-1beta and TNFalpha increased IL-8 production but did not affect the production of IL-8 stimulated by cytokines alone.	Bismuth	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
15664665-7	2005	The specific p38 mitogen-activated protein kinase (MAPK) inhibitor SB 203580 reduced IL-8 production stimulated by the combination of BK and IL-1beta as well as the IL-1beta-stimulated IL-8 production.	SB 203580	67-76	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
15664665-5	2005	Similar to BK, the calcium ionophore A23187 also upregulated the stimulatory effect of IL-1beta and TNFalpha on IL-8 production.	Calcimycin	37-43	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
15749028-4	2005	IL-8 increased DNA synthesis of Caco2 in a dose dependent manner and this was inhibited by ADAM, EGFR kinase, and MEK inhibitors.	caco2	32-37	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15749028-5	2005	IL-8 transiently induced EGFR tyrosine phosphorylation after 5-90 min and this was completely inhibited by ADAM inhibitor.	Tyrosine	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15632177-7	2005	This effect was most pronounced with the chemokine, interleukin-8, where alkyl-linked tetrameric cyclitols were essentially inactive unless a spacer of &gt;7 carbon atoms was used.	Carbon	158-164	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
15615716-7	2005	Blockade of MEK1 by PD98059 suppresses c-Fos and Fra-1 expression and, thus, affects two counteractive signals for IL-8 mRNA synthesis simultaneously.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
15760676-4	2005	However, the regulation of IL-8 production seems to be mediated via a cAMP-independent PKA pathway, since drugs known to enhance cAMP concentrations [PGE2, cholera toxin and dibutyryl cAMP] decrease IL-8 production in irradiated cells by down-regulating NF-kappa B activation in response to UVB radiation.	Cyclic AMP	129-133	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
15760676-4	2005	However, the regulation of IL-8 production seems to be mediated via a cAMP-independent PKA pathway, since drugs known to enhance cAMP concentrations [PGE2, cholera toxin and dibutyryl cAMP] decrease IL-8 production in irradiated cells by down-regulating NF-kappa B activation in response to UVB radiation.	Cyclic AMP	129-133	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
15760676-1	2005	We have previously demonstrated that treatment of the human keratinocyte cell line NCTC 2544 with a UVB dose equivalent to 1h exposure (100 mJ/cm2) results in a significant increase of IL-8 production.	Hydrogen	123-125	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
15760676-4	2005	However, the regulation of IL-8 production seems to be mediated via a cAMP-independent PKA pathway, since drugs known to enhance cAMP concentrations [PGE2, cholera toxin and dibutyryl cAMP] decrease IL-8 production in irradiated cells by down-regulating NF-kappa B activation in response to UVB radiation.	Cyclic AMP	70-74	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
15760676-4	2005	However, the regulation of IL-8 production seems to be mediated via a cAMP-independent PKA pathway, since drugs known to enhance cAMP concentrations [PGE2, cholera toxin and dibutyryl cAMP] decrease IL-8 production in irradiated cells by down-regulating NF-kappa B activation in response to UVB radiation.	Dinoprostone	150-154	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
15760676-4	2005	However, the regulation of IL-8 production seems to be mediated via a cAMP-independent PKA pathway, since drugs known to enhance cAMP concentrations [PGE2, cholera toxin and dibutyryl cAMP] decrease IL-8 production in irradiated cells by down-regulating NF-kappa B activation in response to UVB radiation.	Dinoprostone	150-154	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
15760676-4	2005	However, the regulation of IL-8 production seems to be mediated via a cAMP-independent PKA pathway, since drugs known to enhance cAMP concentrations [PGE2, cholera toxin and dibutyryl cAMP] decrease IL-8 production in irradiated cells by down-regulating NF-kappa B activation in response to UVB radiation.	Cyclic AMP	129-133	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
15760676-4	2005	However, the regulation of IL-8 production seems to be mediated via a cAMP-independent PKA pathway, since drugs known to enhance cAMP concentrations [PGE2, cholera toxin and dibutyryl cAMP] decrease IL-8 production in irradiated cells by down-regulating NF-kappa B activation in response to UVB radiation.	Cyclic AMP	129-133	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
15760676-5	2005	Using PMA (a potent pharmacological activator of PKC) and calphostin C (a specific PKC inhibitor), we demonstrated an up-regulation of IL-8 in NCTC 2544 cells and a down-regulation of the cytokine in UVB-irradiated cells, respectively.	Tetradecanoylphorbol Acetate	6-9	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
15760676-7	2005	Finally, we concluded that a cAMP-independent PKA activation and a PKC-associated pathway are probably involved in the regulation of UVB-induced IL-8 synthesis in human keratinocytes.	Cyclic AMP	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
15795529-4	2005	Competitive inhibition of the IL-8 receptor CXCR2 with the small molecule inhibitor SB225002 resulted in a 45-70% decrease in cervical explant susceptibility to HIV-1 infection.	SB 225002	84-92	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
15695543-0	2005	Ultrafine carbon particles induce interleukin-8 gene transcription and p38 MAPK activation in normal human bronchial epithelial cells.	Carbon	10-16	C-X-C motif chemokine ligand 8	Homo sapiens	34-47
15679717-4	2005	RESULTS: The release of GM-CSF, RANTES and IL-8 in ISC was significantly reduced by BDP plus salbutamol or formoterol as compared with either drug alone (P &lt; 0.0001).	Formoterol Fumarate	107-117	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
15679717-4	2005	RESULTS: The release of GM-CSF, RANTES and IL-8 in ISC was significantly reduced by BDP plus salbutamol or formoterol as compared with either drug alone (P &lt; 0.0001).	Beclomethasone	84-87	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
15679717-4	2005	RESULTS: The release of GM-CSF, RANTES and IL-8 in ISC was significantly reduced by BDP plus salbutamol or formoterol as compared with either drug alone (P &lt; 0.0001).	Albuterol	93-103	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
15498828-6	2005	IL-8 release was blocked by actinomycin D or cycloheximide, but the inhibitors had no effect on VEGF release, suggesting that IL-8 secretion required de novo synthesis whereas VEGF was secreted from preformed stores.	Dactinomycin	28-41	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15498828-6	2005	IL-8 release was blocked by actinomycin D or cycloheximide, but the inhibitors had no effect on VEGF release, suggesting that IL-8 secretion required de novo synthesis whereas VEGF was secreted from preformed stores.	Cycloheximide	45-58	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15498828-10	2005	These findings suggest that bacteria-derived tripeptides stimulate human PMN to release VEGF and IL-8, which activate endothelial cells and induce angiogenesis by a paracrine feedforward mechanism involving endothelial IL-8 upregulation.	tripeptides	45-56	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
15498828-10	2005	These findings suggest that bacteria-derived tripeptides stimulate human PMN to release VEGF and IL-8, which activate endothelial cells and induce angiogenesis by a paracrine feedforward mechanism involving endothelial IL-8 upregulation.	tripeptides	45-56	C-X-C motif chemokine ligand 8	Homo sapiens	219-223
15695543-4	2005	Here, we report that carbonaceous ultrafine particles consisting of synthetic elemental carbon particles (UfCP) markedly increase the expression of IL-8 mRNA and protein in normal human bronchial epithelial (NHBE) cells.	carbonaceous	21-33	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
15695543-4	2005	Here, we report that carbonaceous ultrafine particles consisting of synthetic elemental carbon particles (UfCP) markedly increase the expression of IL-8 mRNA and protein in normal human bronchial epithelial (NHBE) cells.	Carbon	21-27	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
15695543-8	2005	Additionally, we observed that UfCP exposure induces the phosphorylation and activation of p38 mitogen-activated protein kinase (MAPK) in a biphasic manner and that the inhibition of p38 MAPK activity can block IL-8 mRNA expression induced by UfCP in NHBE cells.	ufcp	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	211-215
15695543-9	2005	These results demonstrate that UfCP-induced expression of IL-8 involves a transcriptional mechanism and activation of p38 MAPK in NHBE cells.	ufcp	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
16142584-7	2005	The highest capacity to simultaneously stimulate IL-8 secretion (quantified by ELISA and by using a multiplexed, particle-based flow cytometric assay) and enhance IL-8 mRNA levels (determined by RT-PCR) was observed with 7beta-hydroxycholesterol and 25-hydroxycholesterol.	cholest-5-en-3 beta,7 alpha-diol	221-245	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
16142584-7	2005	The highest capacity to simultaneously stimulate IL-8 secretion (quantified by ELISA and by using a multiplexed, particle-based flow cytometric assay) and enhance IL-8 mRNA levels (determined by RT-PCR) was observed with 7beta-hydroxycholesterol and 25-hydroxycholesterol.	cholest-5-en-3 beta,7 alpha-diol	221-245	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
15540988-6	2005	Chemoattractant cytokines [e.g. VEGF (vascular endothelial growth factor), TGF-beta1 (transforming growth factor-beta1) and IL-8] are important regulators of inflammation-induced angiogenesis and are directly modulated by nitric oxide.	Nitric Oxide	222-234	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
15564333-7	2005	Treatment of adipose tissue and skeletal muscle with sulfasalazine and BAY 11-7082 significantly inhibited the release of IL-6, IL-8, and TNF-alpha; NF-kappa B p65 DNA-binding activity; and IKK-beta protein expression (P &lt; 0.05, by Newman-Keuls test).	Sulfasalazine	53-66	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
15564333-7	2005	Treatment of adipose tissue and skeletal muscle with sulfasalazine and BAY 11-7082 significantly inhibited the release of IL-6, IL-8, and TNF-alpha; NF-kappa B p65 DNA-binding activity; and IKK-beta protein expression (P &lt; 0.05, by Newman-Keuls test).	3-(4-methylphenylsulfonyl)-2-propenenitrile	71-82	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
15760531-4	2005	RESULTS: After operation, the contents of IL-6, IL-8, TNF-alpha, CK-MB and cTnI were significantly higher in CCABG group than those before operation and those in OPCABG group, while most of these parameters showed little change in OPCABG group both in operative or postoperative period.	ccabg	109-114	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
15901049-6	2005	Additionally, IL-8 was significantly reduced in BP, and ICAM-1 and albumin were present in lower concentrations in BAP.	benzylaminopurine	115-118	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
15613411-3	2005	The aim of this study was to describe the temporal and spatial expression of IL-8 in human endometrial endothelial cells (HEEC) in vivo and to compare the in vitro regulation of IL-8 expression by sex steroids in HEEC from women with or without endometriosis.	Steroids	201-209	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
15613411-8	2005	The effects of estradiol (5 x 10(-8) m), progesterone (10(-7) m), or both on IL-8 mRNA and protein levels were analyzed by RT-PCR and ELISA, respectively.	Estradiol	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
15613411-8	2005	The effects of estradiol (5 x 10(-8) m), progesterone (10(-7) m), or both on IL-8 mRNA and protein levels were analyzed by RT-PCR and ELISA, respectively.	Progesterone	41-53	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
15613411-9	2005	Sex steroids reduced the expression of IL-8 mRNA and protein in HEEC from women without endometriosis.	Steroids	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
15777258-5	2005	Thiopental and ketamine inhibit the endotoxin-induced TNF-alpha, IL-1 and IL-8 responses and increase IL-10 release in vitro.	Thiopental	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
15777258-5	2005	Thiopental and ketamine inhibit the endotoxin-induced TNF-alpha, IL-1 and IL-8 responses and increase IL-10 release in vitro.	Ketamine	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
15585673-5	2005	On the basis of simulated mutation analyses, we hypothesized that this protease resistance is due to disulfide bond-related tertiary folding in IL-8/CXCL8.	Disulfides	101-110	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
15585673-5	2005	On the basis of simulated mutation analyses, we hypothesized that this protease resistance is due to disulfide bond-related tertiary folding in IL-8/CXCL8.	Disulfides	101-110	C-X-C motif chemokine ligand 8	Homo sapiens	149-154
15823106-0	2005	Predictive value of serum interleukin-8 levels in ovarian cancer patients treated with paclitaxel-containing regimens.	Paclitaxel	87-97	C-X-C motif chemokine ligand 8	Homo sapiens	26-39
15823106-1	2005	Previous findings showed that paclitaxel induces interleukin-8 (IL-8) transcription and secretion in ovarian cancer cells in vitro.	Paclitaxel	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	49-62
15823106-1	2005	Previous findings showed that paclitaxel induces interleukin-8 (IL-8) transcription and secretion in ovarian cancer cells in vitro.	Paclitaxel	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
15823106-2	2005	We hypothesized that paclitaxel treatment, which is a standard care for ovarian cancer patients, may increase the secretion of IL-8, resulting in the elevated serum IL-8 levels.	Paclitaxel	21-31	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
15823106-2	2005	We hypothesized that paclitaxel treatment, which is a standard care for ovarian cancer patients, may increase the secretion of IL-8, resulting in the elevated serum IL-8 levels.	Paclitaxel	21-31	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
15823106-3	2005	In this study, we investigated the relationship between paclitaxel exposure and IL-8 levels of an ovarian and a breast carcinoma cell line in vitro and serums of patients with ovarian carcinoma.	Paclitaxel	56-66	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
15823106-5	2005	However, supernatant levels of IL-8 assessed by enzyme-linked immunosorbent assay before and after treatment with different concentrations of paclitaxel were significantly lower in MCF-7 than in MDAH 2774.	Paclitaxel	142-152	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
15823106-8	2005	The basal level of IL-8 after paclitaxel-containing treatment was found to be significantly higher in the serums of patients who had high tumor burden than in patients who had optimal debulking surgery and low tumor burden.	Paclitaxel	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
15823106-9	2005	These data strongly suggest that IL-8 may be an important predictive marker for tumor volume as well as sensitivity to paclitaxel.	Paclitaxel	119-129	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
15868064-0	2005	Reaction characteristics of a tooth-bleaching agent containing H2O2 and NaF: in vitro study of crystal structure change in treated hydroxyapatite and chemical states of incorporated fluorine.	Durapatite	131-145	C-X-C motif chemokine ligand 8	Homo sapiens	63-75
15868064-0	2005	Reaction characteristics of a tooth-bleaching agent containing H2O2 and NaF: in vitro study of crystal structure change in treated hydroxyapatite and chemical states of incorporated fluorine.	Fluorine	182-190	C-X-C motif chemokine ligand 8	Homo sapiens	63-75
15868064-1	2005	This in vitro study was performed to elucidate the reaction mechanism of sodium fluoride (NaF), which is added to tooth-bleaching agents to lessen the adverse effect of hydrogen peroxide (H2O2) on teeth.	Sodium Fluoride	73-88	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
15868064-1	2005	This in vitro study was performed to elucidate the reaction mechanism of sodium fluoride (NaF), which is added to tooth-bleaching agents to lessen the adverse effect of hydrogen peroxide (H2O2) on teeth.	Hydrogen Peroxide	169-186	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
15868064-1	2005	This in vitro study was performed to elucidate the reaction mechanism of sodium fluoride (NaF), which is added to tooth-bleaching agents to lessen the adverse effect of hydrogen peroxide (H2O2) on teeth.	Hydrogen Peroxide	188-192	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
15868064-3	2005	In the H2O2/NaF solutions, however, fluorine compounds that could not be identified by X-ray diffraction (XRD) due to the smallness of the products were formed on the surface of the HAP.	Hydrogen Peroxide	7-11	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
15868064-3	2005	In the H2O2/NaF solutions, however, fluorine compounds that could not be identified by X-ray diffraction (XRD) due to the smallness of the products were formed on the surface of the HAP.	Fluorine	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
15868064-5	2005	In H2O2/NaF solution, DCPD also transformed easily to FHAP and CaF2, which are favorable to the remineralization process on the tooth surface.	2'-deoxycytidine diphosphate	22-26	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
15868064-6	2005	Thus, the mechanism of NaF was elucidated, and its use together with H2O2 for tooth bleaching was proved to be effective.	Hydrogen Peroxide	69-73	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
15952644-1	2005	OBJECTIVE: This study was to investigate the effect of crocidolite fibers on IL-8 protein and mRNA levels in A549 cells cultured supernatant and the role of tyrosine kinase inhibitor PD98059 on IL-8 expression.	Asbestos, Crocidolite	55-66	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
15952644-1	2005	OBJECTIVE: This study was to investigate the effect of crocidolite fibers on IL-8 protein and mRNA levels in A549 cells cultured supernatant and the role of tyrosine kinase inhibitor PD98059 on IL-8 expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	183-190	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
15952644-3	2005	RESULTS: After incubating cells with 100 microg/ml of crocidolite, IL-8 protein releasing in supernatant was significantly increased and IL-8 mRNA was also higher than that of control, the differences were statistically significant (P &lt; 0.05), however both IL-8 protein and mRNA was abrogated by pretreating cells with tyrosine kinase inhibitor PD98059.	Asbestos, Crocidolite	54-65	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
15952644-3	2005	RESULTS: After incubating cells with 100 microg/ml of crocidolite, IL-8 protein releasing in supernatant was significantly increased and IL-8 mRNA was also higher than that of control, the differences were statistically significant (P &lt; 0.05), however both IL-8 protein and mRNA was abrogated by pretreating cells with tyrosine kinase inhibitor PD98059.	Asbestos, Crocidolite	54-65	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
15952644-3	2005	RESULTS: After incubating cells with 100 microg/ml of crocidolite, IL-8 protein releasing in supernatant was significantly increased and IL-8 mRNA was also higher than that of control, the differences were statistically significant (P &lt; 0.05), however both IL-8 protein and mRNA was abrogated by pretreating cells with tyrosine kinase inhibitor PD98059.	Asbestos, Crocidolite	54-65	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
15952644-3	2005	RESULTS: After incubating cells with 100 microg/ml of crocidolite, IL-8 protein releasing in supernatant was significantly increased and IL-8 mRNA was also higher than that of control, the differences were statistically significant (P &lt; 0.05), however both IL-8 protein and mRNA was abrogated by pretreating cells with tyrosine kinase inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	348-355	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
15952644-4	2005	CONCLUSION: IL-8 was shown as overexpression and could be decreased by PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	71-78	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
15668340-7	2005	Dipyridamole delayed maximal synthesis of interleukin-8 but did not alter cyclooxygenase-2 accumulation.	Dipyridamole	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	42-55
15804113-11	2005	The results indicate that the expression of cytokines (IL-2, IL-8, IL-10) in EPS can serve as a valuable marker for the diagnosis of CP.	eps	77-80	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
15709756-6	2005	Addition of AlCl(3) and NaF to the reduced double mutant after incubation with stoichiometric MgADP or 200 microM MgADP irreversibly inactivated the steady state ATPase activity with rate constants of 1.5 x10(-2) and 4.1 x 10(-2) min(-1), respectively.	Adenosine Diphosphate	94-99	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
15709756-6	2005	Addition of AlCl(3) and NaF to the reduced double mutant after incubation with stoichiometric MgADP or 200 microM MgADP irreversibly inactivated the steady state ATPase activity with rate constants of 1.5 x10(-2) and 4.1 x 10(-2) min(-1), respectively.	Adenosine Diphosphate	114-119	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
15699163-6	2005	The presence of clinically relevant heparin concentrations in human whole blood increased LPS-induced production of the proinflammatory cytokine IL-8.	Heparin	36-43	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
15652280-5	2005	When CYSST (1mg/ml) was added, the production of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8 was significantly inhibited about 37, 33.6, and 48%, respectively on phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells.	cysst	5-10	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
15842830-2	2005	METHODS: The renal tubular cells were cultured and exposed to sodium fluoride (NaF) in 1, 5, 7.5, 12.5 mg F-/L level.	Sodium Fluoride	62-77	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
15652492-4	2005	Overexpression of human superoxide dismutase (SOD) by adenovirus-mediated gene transfer or addition of exogenous hydrogen peroxide (H(2)O(2)) significantly enhanced TNF-alpha-induced IL-8 mRNA expression.	Hydrogen Peroxide	113-130	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
15694463-7	2005	When NHBE were stimulated with PM(2.5-10), PM2.5, and UF PM, in the presence or absence of inhibitors of TLR2 and TLR4 activation, a blocking antibody to TLR2 inhibited production of IL-8, while TLR4 antagonist E5531 or the LPS inhibitor Polymixin B had no effect.	E 5531	211-216	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
15709200-14	2005	Furthermore, in Adriamycin-resistant MCF-7 cells highly expressing multidrug resistance gene-1, DHMEQ also exhibited the above capability, including down-regulation of IL-8.	Doxorubicin	16-26	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
15673867-6	2005	Lidocaine (0.5 mg/mL) decreased IL-1beta (1.89 +/- 0.11 versus 4.16 +/- 1.27 pg/mL; P = 0.009), IL-6 (65.5 +/- 5.14 versus 162 +/- 11.5 pg/mL; P &lt; 0.001), and IL-8 (3869 +/- 785 versus 14,961 +/- 406 pg/mL; P &lt; 0.001) concentrations compared with the control.	Lidocaine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
15652235-5	2005	Histamine induced concentration- and time-dependent production of granulocyte-macrophage-colony stimulating factor (GM-CSF), interleukin (IL)-8 and IL-6, which was completely blocked by olopatadine, an H1 antagonist.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	125-143
15652235-5	2005	Histamine induced concentration- and time-dependent production of granulocyte-macrophage-colony stimulating factor (GM-CSF), interleukin (IL)-8 and IL-6, which was completely blocked by olopatadine, an H1 antagonist.	Olopatadine Hydrochloride	186-197	C-X-C motif chemokine ligand 8	Homo sapiens	125-143
15494208-3	2005	Both fMLP and IL-8 increased CD38 in supernatants, which was inhibitable with PMSF.	Phenylmethylsulfonyl Fluoride	78-82	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
15494208-7	2005	The addition of SB20358 blocked the decrease of CD38 on neutrophils and the increase in supernatants induced by fMLP or IL-8, whereas PD98059 did not.	Ethyl 2-amino-5-Boc-6,7-dihydro-4H-thieno[3,2-c]pyridine-3-carboxylate	16-23	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
15652235-10	2005	PD98059 preferentially inhibited GM-CSF production whereas BAY 11-8702 prevented IL-8 and IL-6 production.	bay 11-8702	59-70	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
15709200-14	2005	Furthermore, in Adriamycin-resistant MCF-7 cells highly expressing multidrug resistance gene-1, DHMEQ also exhibited the above capability, including down-regulation of IL-8.	dehydroxymethylepoxyquinomicin	96-101	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
15687063-7	2005	In particular, the preinflammatory cytokine interleukin 8 and one of its receptors, chemokine receptor 4, seemed to play important roles in early-stage response to heavy metal exposure and were down-regulated.	Metals	170-175	C-X-C motif chemokine ligand 8	Homo sapiens	44-57
15750714-9	2005	CONCLUSIONS: The present data indicate the differential regulation by DLE of the production of TNFalpha, IL-6, and IL-8 cytokines, associated with effects on TLR2 and TLR4 expression and NF-kappaB and cAMP activities.	Cyclic AMP	201-205	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
15696082-4	2005	OBJECTIVE: We sought to investigate the effect of a 2-week course of oral corticosteroid (methylprednisolone, 40 mg/d) on the expression of CXC chemokines (IL-8 and IFN-gamma-inducible protein 10 [IP-10]) and CC chemokines (eotaxin and monocyte chemotactic proteins [MCPs] 1-4) in endoscopic biopsy specimens of 13 patients with moderate-to-severe asthma.	Methylprednisolone	90-108	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
15647850-0	2005	High-dose hydrocortisone reduces expression of the pro-inflammatory chemokines CXCL8 and CXCL10 in SARS coronavirus-infected intestinal cells.	Hydrocortisone	10-24	C-X-C motif chemokine ligand 8	Homo sapiens	79-84
15647850-5	2005	High hydrocortisone concentrations (&gt; or =50 microg/ml) completely prevented increased DNA binding activity of AP-1 and NF-kappaB and inhibited up-regulation of CXCL8 and CXCL10, but did not reduce chemokine expression to basal levels.	Hydrocortisone	5-19	C-X-C motif chemokine ligand 8	Homo sapiens	164-169
15751881-1	2005	We report 784-nm (1G4 --&gt; 3H5 transition) amplified spontaneous emission (ASE) from Tm3+-doped fluoride (ZrF4-BaF2-LaF3-AlF3-NaF) glass fiber pumped by an 1120-nm fiber laser.	ase	77-80	C-X-C motif chemokine ligand 8	Homo sapiens	128-131
15585560-6	2005	The increase in IL-8 secretion was inhibited by PD98059, an inhibitor of extracellular signal-regulated kinase 1/2.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	48-55	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
15652404-2	2005	Abeta(1-42) (5 microM) applied for 8 h induced the expression and increased the production of the pro-inflammatory cytokines IL-6, IL-1beta, TNF-alpha, the inducible enzyme COX-2 and chemokine IL-8.	UNII-042A8N37WH	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
15671221-0	2005	Glutamine modulates LPS-induced IL-8 production through IkappaB/NF-kappaB in human fetal and adult intestinal epithelium.	Glutamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
15671221-6	2005	Gln supplementation partially prevented the LPS-induced elevation of IL-8 in both cell types.	Glutamine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
15698409-0	2005	Differential modulation of interleukin 8 by interleukin 4 and interleukin 10 in HepG2 cells treated with acetaldehyde.	Acetaldehyde	105-117	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
15698409-2	2005	The purpose of this work was to study the regulation of IL-8 by IL-10 and IL-4 in HepG2 cells treated with acetaldehyde (Ac).	Acetaldehyde	107-119	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
15698409-2	2005	The purpose of this work was to study the regulation of IL-8 by IL-10 and IL-4 in HepG2 cells treated with acetaldehyde (Ac).	Acetaldehyde	121-123	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
15698409-4	2005	RESULTS: Ac treatment produced an increment in IL-8 induction and secretion that was prevented by IL-4 pretreatment, while IL-10 pretreatment failed to decrease Ac-induced IL-8 production.	Acetaldehyde	9-11	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
15751881-1	2005	We report 784-nm (1G4 --&gt; 3H5 transition) amplified spontaneous emission (ASE) from Tm3+-doped fluoride (ZrF4-BaF2-LaF3-AlF3-NaF) glass fiber pumped by an 1120-nm fiber laser.	tm3+-doped fluoride	87-106	C-X-C motif chemokine ligand 8	Homo sapiens	128-131
15531761-2	2005	We recently demonstrated that glucocorticoids and beta(2)-agonists additively or synergistically suppress tumor necrosis factor-alpha (TNFalpha)-induced production of chemokines eotaxin and interleukin-8 (IL-8), respectively, in human airway smooth muscle (HASM) cells, which may partly explain their combined benefits in asthma.	beta(2)	50-57	C-X-C motif chemokine ligand 8	Homo sapiens	190-203
15531761-4	2005	We reported here that the PPARgamma agonists 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) and troglitazone, but not PPARalpha agonist WY-14643, inhibited TNFalpha-induced production of eotaxin and monocyte chemotactic protein-1 (MCP-1) but not IL-8.	Troglitazone	91-103	C-X-C motif chemokine ligand 8	Homo sapiens	241-245
15531761-2	2005	We recently demonstrated that glucocorticoids and beta(2)-agonists additively or synergistically suppress tumor necrosis factor-alpha (TNFalpha)-induced production of chemokines eotaxin and interleukin-8 (IL-8), respectively, in human airway smooth muscle (HASM) cells, which may partly explain their combined benefits in asthma.	beta(2)	50-57	C-X-C motif chemokine ligand 8	Homo sapiens	205-209
15556942-9	2005	IL8 treatment resulted in the increase of cGMP level that was inhibited by the IP(3) receptor blocker but not a protein kinase C inhibitor.	Cyclic GMP	42-46	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
18969806-5	2005	In addition, the effects of heavy metals (Cu(2+), Cd(2+), Fe(3+)), fluoride (NaF), benzene and dimethylsulphoxide on cholinesterase activities were evaluated.	Fluorides	67-75	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
15556942-14	2005	These results demonstrate that CD38 is stimulated by sequential activation of IL8 receptor, IP(3)-mediated Ca(2+) rise, and cGMP/protein kinase G and that CD38 plays an essential role in IL8-induced migration of LAK cells.	Inositol 1,4,5-Trisphosphate	92-97	C-X-C motif chemokine ligand 8	Homo sapiens	187-190
15588914-3	2005	DON (62.5-500 ng/ml) also significantly upregulated IL-2 and IL-8 production following prestimulation with phorbol myristate acetate and ionomycin.	deoxynivalenol	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
15627478-4	2005	On the contrary, both RSG and TRO significantly potentiated TNF-alpha-induced production of granulocyte/macrophage-colony-stimulating factor, interleukin (IL)-6 and/or IL-8 in these cells.	Rosiglitazone	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
15627478-4	2005	On the contrary, both RSG and TRO significantly potentiated TNF-alpha-induced production of granulocyte/macrophage-colony-stimulating factor, interleukin (IL)-6 and/or IL-8 in these cells.	Troglitazone	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
15461590-7	2005	Furthermore, overexpression of LPP-1 partially attenuated LPA-induced increases in the intracellular Ca2+ concentration, phosphorylation of IkappaB (inhibitory kappaB) and translocation of NF-kappaB (nuclear factor-kappaB) to the nucleus, and almost completely prevented IL-8 secretion.	lysophosphatidic acid	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	271-275
15588914-3	2005	DON (62.5-500 ng/ml) also significantly upregulated IL-2 and IL-8 production following prestimulation with phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	107-132	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
15588914-3	2005	DON (62.5-500 ng/ml) also significantly upregulated IL-2 and IL-8 production following prestimulation with phorbol myristate acetate and ionomycin.	Ionomycin	137-146	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
15588914-10	2005	In contrast, 15-ADON at 62.5-500 ng/ml and 3-ADON at 625-5000 ng/ml upregulated IL-8 production but FX and NIV had no effect.	15-acetyldeoxynivalenol	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
15588914-10	2005	In contrast, 15-ADON at 62.5-500 ng/ml and 3-ADON at 625-5000 ng/ml upregulated IL-8 production but FX and NIV had no effect.	3-acetyldeoxynivalenol	43-49	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
15588914-12	2005	Although DON shared its capacity to induce apoptosis and potentiate IL-8 production with other 8-ketotrichothecenes, it appeared to be unique in its capacity to upregulate IL-2.	deoxynivalenol	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
15588680-6	2005	The production of IL-6 and IL-8 was dose-dependently inhibited by pretreatment with ZST (0.01-1 mg/ml) on IL-1beta and Abeta-stimulated U373MG cells.	UNII-042A8N37WH	119-124	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
15650393-0	2005	Inhibition of NFkappaB activation and IL-8 expression in human bronchial epithelial cells by acrolein.	Acrolein	93-101	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
15659119-0	2005	Signal pathways underlying homocysteine-induced production of MCP-1 and IL-8 in cultured human whole blood.	Homocysteine	27-39	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
15659119-5	2005	CONCLUSION: Hcy-induced MCP-1 and IL-8 production is mediated by activated signaling pathways such as PKC, CaM, MAPK, and NF-kappaB.	Homocysteine	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
15696447-13	2005	Serum IL-8 levels correlated significantly with FE UA (P &lt; 0.001; r = 0.785) and inversely with serum UA level (P = 0.044; r = -0.509); neither IL-6 nor TNF-alpha level showed such correlations.	Uric Acid	51-53	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
15650393-4	2005	Cell exposure to acrolein dose-dependently suppressed IL-8 mRNA levels in HBE1 cells (26, 40, and 79% at 5, 10, and 25 microM acrolein concentrations, respectively) and resulted in corresponding decreases in IL-8 production.	Acrolein	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
15650393-4	2005	Cell exposure to acrolein dose-dependently suppressed IL-8 mRNA levels in HBE1 cells (26, 40, and 79% at 5, 10, and 25 microM acrolein concentrations, respectively) and resulted in corresponding decreases in IL-8 production.	Acrolein	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
15650393-7	2005	In summary, our results demonstrate that acrolein can suppress inflammatory processes in the airways by inhibiting epithelial IL-8 production through direct or indirect inhibitory effects on NFkappaB activation.	Acrolein	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
16179748-1	2005	Homocysteine, cytokines (IL-18, IL-6, IL-8) are involved in vascular inflammation and coronary artery disease.	Homocysteine	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
15539624-11	2005	Importantly, IL-8 significantly induced CRP release in PHHs by 58.675+/-19.1-fold, which was blockable by LY333531.	ruboxistaurin	106-114	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
15641067-4	2005	This study was undertaken to test the hypothesis that IL-8 promotes chondrocyte hypertrophy by modulating chondrocyte PiT-1 expression and sodium-dependent Pi uptake, and to assess differential roles in this activity.	Sodium	139-145	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
15641067-8	2005	IL-8, but not IL-1 or the CXCR2 ligand growth-related oncogene alpha, induced PiT-1 expression and increased sodium-dependent Pi uptake by &gt;40% in chondrocytes.	Sodium	109-115	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15641067-9	2005	The sodium/phosphate cotransport inhibitor phosphonoformic acid blocked IL-8-induced chondrocyte hypertrophic differentiation.	Foscarnet	43-63	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
15641067-12	2005	CONCLUSION: Our results link low-grade IL-8-mediated cartilaginous inflammation in OA to altered chondrocyte differentiation and disease progression through PiT-1 expression and sodium-dependent Pi uptake mediated by CXCR1 signaling.	Sodium	178-184	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
16179748-2	2005	Homocysteine influences endothelial IL-6 and IL-8 cytokine expression and release, however, an association between homocysteine and IL-18 has not been previously investigated in endothelial/smooth muscle cells and or in coronary artery disease.	Homocysteine	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
15843228-11	2005	Initial IL-8 serum levels were significantly higher in the hydrocortisone group up to 12 h after study entry, and significantly decreased from 715 to 17 pg/mL at the end of the observation period.	Hydrocortisone	59-73	C-X-C motif chemokine ligand 8	Homo sapiens	8-12
15894821-6	2005	However, following transfection with a functional mutant of TLR4 (C3H/HeJ, TLR4 Dicd) or addition of anti-human TLR4 mAb, IL-8 expression was obviously decreased, NF-kappaB activity in cells remarkably inhibited, and the adhesion force of monocyte significantly reduced.	dicd	80-84	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
15606618-6	2005	IkappaB-alpha phosphorylation inhibitor, BAY 11-7082, and p38 MAPK inhibitor, SB 203580 could decrease the release of IL-8, IP-10 and MCP-1 in the coculture.	3-(4-methylphenylsulfonyl)-2-propenenitrile	41-52	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
15606618-6	2005	IkappaB-alpha phosphorylation inhibitor, BAY 11-7082, and p38 MAPK inhibitor, SB 203580 could decrease the release of IL-8, IP-10 and MCP-1 in the coculture.	SB 203580	78-87	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
15617523-0	2005	Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture.	Diaminopimelic Acid	21-40	C-X-C motif chemokine ligand 8	Homo sapiens	180-193
15617523-0	2005	Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture.	desmuramylpeptides	52-70	C-X-C motif chemokine ligand 8	Homo sapiens	180-193
15617523-2	2005	We found marked synergistic IL-8 secretion induced by MDP or DAP-containing DMP in combination with synthetic TLR agonists in THP-1 cells.	Diaminopimelic Acid	61-64	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
15617523-2	2005	We found marked synergistic IL-8 secretion induced by MDP or DAP-containing DMP in combination with synthetic TLR agonists in THP-1 cells.	dmp	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
15617523-3	2005	Suppression of the mRNA expression of nucleotide-binding oligomerization domain (NOD)1 and NOD2 by RNA interference specifically inhibited the synergistic IL-8 secretion induced by DMP and MDP with these TLR agonists respectively.	dmp	181-184	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
15617523-3	2005	Suppression of the mRNA expression of nucleotide-binding oligomerization domain (NOD)1 and NOD2 by RNA interference specifically inhibited the synergistic IL-8 secretion induced by DMP and MDP with these TLR agonists respectively.	Acetylmuramyl-Alanyl-Isoglutamine	189-192	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
15617523-4	2005	In accordance with the above results, enhanced IL-8 mRNA expression and the activation of nuclear factor (NF)-kappaB induced by MDP or DMP in combination with synthetic TLR agonists were markedly suppressed in NOD2- and NOD1-silenced cells respectively.	dmp	135-138	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
15843228-15	2005	Starting S-100B, IL-8 and PMN elastase values of the hydrocortisone group were within the ranges already known in patients with out-of-hospital cardiac arrest or severe traumatic brain injury.	Hydrocortisone	53-67	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
15843228-16	2005	Stress doses of hydrocortisone resulted in a significant reduction in IL-8 serum, but not in S-100B serum and PMN elastase plasma concentrations in patients with hyperdynamic septic shock.	Hydrocortisone	16-30	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
17532680-7	2005	Furthermore, treatment with NAC 1200 mg/day was more efficacious than NAC 600 mg/day in reducing IL-8 levels and difficulty of expectoration, while the two active regimens had similar beneficial effects on lung function and other clinical outcomes (cough intensity and frequency, and lung auscultation).	Acetylcysteine	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
17532680-7	2005	Furthermore, treatment with NAC 1200 mg/day was more efficacious than NAC 600 mg/day in reducing IL-8 levels and difficulty of expectoration, while the two active regimens had similar beneficial effects on lung function and other clinical outcomes (cough intensity and frequency, and lung auscultation).	Acetylcysteine	70-73	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
15618178-6	2005	Northern blot analyses after the addition of the transcriptional inhibitor actinomycin D revealed increased IL-8 mRNA stability in THP-1 cells treated with Stx1 or Stx1 plus LPS.	Dactinomycin	75-88	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
16280061-13	2005	There were significant negative correlations between the PaO2/FiO2 ratio and blood levels of NE and IL-8.	pao2	57-61	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
16280061-13	2005	There were significant negative correlations between the PaO2/FiO2 ratio and blood levels of NE and IL-8.	fio2	62-66	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
16280061-15	2005	The mean blood levels of plasminogen activator inhibitor-1, NE, and IL-8 were significantly decreased from 48 hours after DHP-PMX treatment.	dhp-pmx	122-129	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
16280061-17	2005	Improvement in the PaO2/FiO2 ratio appeared to be related to the decreases in blood NE and IL-8 levels.	pao2	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
16280061-17	2005	Improvement in the PaO2/FiO2 ratio appeared to be related to the decreases in blood NE and IL-8 levels.	fio2	24-28	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
14963719-5	2005	In both NS and betamethasone patients, the levels of IL-1beta and IL-8 had significantly decreased by the 3rd and 2nd weeks after therapy, respectively.	Betamethasone	15-28	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
15582208-8	2005	Cytotoxicity in CEPI mainly correlated with presence and concentrations of surfactants, and IL-8 release to clinical signs and/or glycol and sodium lactate concentrations.	Sodium Lactate	141-155	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
15675582-0	2005	[Phase I study of the combination of nedaplatin (NED), adriamycin (ADM), and 5-fluorouracil (5-FU) (NAF) for treatment of unresectable advanced esophageal cancer].	Fluorouracil	77-91	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
15675582-0	2005	[Phase I study of the combination of nedaplatin (NED), adriamycin (ADM), and 5-fluorouracil (5-FU) (NAF) for treatment of unresectable advanced esophageal cancer].	Fluorouracil	93-97	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
15618163-9	2005	The upregulation of ICAM-1, IL-6, and IL-8 was completely inhibited by pretreating the cells with an NF-kappaB activation inhibitor, l-1-tosylamido-2-phenylethyl chloromethyl ketone.	Tosylphenylalanyl Chloromethyl Ketone	133-181	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
16076033-14	2005	Nevertheless, the impact of catecholamines on IL-8 synthesis and expression of CD15, CD44, and CD54 is limited.	Catecholamines	28-42	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
15611265-0	2005	Inhibition of human neutrophil IL-8 production by hydrogen peroxide and dysregulation in chronic granulomatous disease.	Hydrogen Peroxide	50-67	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
16435585-5	2005	The amount of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta, IL-6, and IL-8 in PBMC culture supernatant was significantly increased in the lipopolysaccaride (LPS)- or desferrioxamine (DFX)-treated cells compared with unstimulated cells.	lipopolysaccaride	162-179	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
16435585-7	2005	Also, DCWGG inhibited TNF-alpha, IL-1alpha, IL-beta, IL-6, and IL-8 production-induced DFX in dose-dependent manner.	Deferoxamine	87-90	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
16173061-3	2005	Cells overexpressing interleukin 10 suppressed the pro-inflammatory cytokines interleukin 8 and interleukin 6 following exposure to 50-300 microM sulfur mustard.	Mustard Gas	146-160	C-X-C motif chemokine ligand 8	Homo sapiens	78-91
15654981-0	2005	Eicosapentaenoic acid and docosahexaenoic acid reduce UVB- and TNF-alpha-induced IL-8 secretion in keratinocytes and UVB-induced IL-8 in fibroblasts.	Eicosapentaenoic Acid	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
15654981-6	2005	In keratinocytes, EPA and DHA were shown to reduce basal secretion of IL-8 by 66% and 63%, respectively (p&lt;0.05), and UVB-induced levels by 66% and 65% at 48 h after 100 mJ per cm2, respectively, (p&lt;0.01).	Eicosapentaenoic Acid	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
15611265-5	2005	Moreover, normal neutrophils treated with catalase (H(2)O(2) scavenger) or diphenyleneiodonium chloride (NADPH oxidase inhibitor) exhibit IL-8 responses comparable to those of CGD neutrophils.	Hydrogen Peroxide	52-60	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
15654981-6	2005	In keratinocytes, EPA and DHA were shown to reduce basal secretion of IL-8 by 66% and 63%, respectively (p&lt;0.05), and UVB-induced levels by 66% and 65% at 48 h after 100 mJ per cm2, respectively, (p&lt;0.01).	Docosahexaenoic Acids	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
15654981-0	2005	Eicosapentaenoic acid and docosahexaenoic acid reduce UVB- and TNF-alpha-induced IL-8 secretion in keratinocytes and UVB-induced IL-8 in fibroblasts.	Eicosapentaenoic Acid	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
15654981-0	2005	Eicosapentaenoic acid and docosahexaenoic acid reduce UVB- and TNF-alpha-induced IL-8 secretion in keratinocytes and UVB-induced IL-8 in fibroblasts.	Docosahexaenoic Acids	26-46	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
15654981-8	2005	In addition, TNF-alpha-induced IL-8 secretion by keratinocytes was reduced by 54% and 42%, respectively, by EPA and DHA (p&lt;0.001).	Eicosapentaenoic Acid	108-111	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
15654981-0	2005	Eicosapentaenoic acid and docosahexaenoic acid reduce UVB- and TNF-alpha-induced IL-8 secretion in keratinocytes and UVB-induced IL-8 in fibroblasts.	Docosahexaenoic Acids	26-46	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
15611265-5	2005	Moreover, normal neutrophils treated with catalase (H(2)O(2) scavenger) or diphenyleneiodonium chloride (NADPH oxidase inhibitor) exhibit IL-8 responses comparable to those of CGD neutrophils.	diphenyleneiodonium	75-103	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
15654981-8	2005	In addition, TNF-alpha-induced IL-8 secretion by keratinocytes was reduced by 54% and 42%, respectively, by EPA and DHA (p&lt;0.001).	Docosahexaenoic Acids	116-119	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
15611265-6	2005	Addition of hydrogen peroxide or an H(2)O(2)-generating system suppresses the sustained IL-8 mRNA and increased protein production observed in CGD neutrophils.	Hydrogen Peroxide	12-29	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
15611265-6	2005	Addition of hydrogen peroxide or an H(2)O(2)-generating system suppresses the sustained IL-8 mRNA and increased protein production observed in CGD neutrophils.	Hydrogen Peroxide	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
16218490-6	2005	Finally, TZDs induce synoviocyte apoptosis and reduce secretion of TNFalpha, IL-6 and IL-8 in synoviocyte from rheumatoid arthritis patients.	Thiazolidinediones	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
15454116-0	2004	Glycyrrhizin and related compounds down-regulate production of inflammatory chemokines IL-8 and eotaxin 1 in a human lung fibroblast cell line.	Glycyrrhizic Acid	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
16356023-18	2005	Montelukast treatment decreased serum and sputum levels of eosinophil cationic protein and interleukin-8 (IL-8), decreased sputum levels of myeloperoxidase, and increased serum and sputum levels of IL-10 (p &lt; 0.001 for all) compared with placebo.	montelukast	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
16356023-18	2005	Montelukast treatment decreased serum and sputum levels of eosinophil cationic protein and interleukin-8 (IL-8), decreased sputum levels of myeloperoxidase, and increased serum and sputum levels of IL-10 (p &lt; 0.001 for all) compared with placebo.	montelukast	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
15939312-7	2005	Fluticasone propionate was able to suppress IL-1beta induced IL-8 protein and promoter activation, using both a -1481 bp fragment and a -133 bp fragment, indicating that the glucocorticoid response element found at -330 bp was not required for fluticasone mediated suppression of IL-8 promoter activation.	Fluticasone	0-22	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
15939312-7	2005	Fluticasone propionate was able to suppress IL-1beta induced IL-8 protein and promoter activation, using both a -1481 bp fragment and a -133 bp fragment, indicating that the glucocorticoid response element found at -330 bp was not required for fluticasone mediated suppression of IL-8 promoter activation.	Fluticasone	0-22	C-X-C motif chemokine ligand 8	Homo sapiens	280-284
15939312-7	2005	Fluticasone propionate was able to suppress IL-1beta induced IL-8 protein and promoter activation, using both a -1481 bp fragment and a -133 bp fragment, indicating that the glucocorticoid response element found at -330 bp was not required for fluticasone mediated suppression of IL-8 promoter activation.	Fluticasone	244-255	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
15939314-7	2005	RESULTS: Salbutamol at concentrations of 10(-4), 10(-5) and 10(-9) M inhibited IL-8, elastase release and migration of neutrophils in an inverse bell-shaped concentration-response manner.	Albuterol	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
15939314-10	2005	CONCLUSIONS: Salbutamol inhibits neutrophil migration and IL-8 and elastase release in a concentration-dependent manner.	Albuterol	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	58-75
15893134-8	2005	In the process of the search for such a unique anti-hypertensive drug, we have recently found that azelnidipine, a newly developed and commercially used long-acting dihydropyridine-based calcium antagonist (DHP), inhibited TNF-alpha-induced activator protein-1 activation and interleukin-8 expression in human umbilical vein endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation.	azelnidipine	99-111	C-X-C motif chemokine ligand 8	Homo sapiens	276-289
16044843-5	2005	Evidence was obtained showing that after a 2-dyas exposure at room temperature in presence of floride NaF, Aluminum foil liberated nearly 1 mg/l of Aluminum, compared with less than 0.04 mg/l in absence of fluoride.	Aluminum	107-115	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
16044843-6	2005	There is reason to believe that in experiments with ascorbic acid NaF prevents the oxidation of ascorbic acid.	Ascorbic Acid	52-65	C-X-C motif chemokine ligand 8	Homo sapiens	66-69
15489227-0	2004	Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.	Serine	79-85	C-X-C motif chemokine ligand 8	Homo sapiens	353-366
15489227-10	2004	Collectively, our results provide evidence for at least five kinases that converge on Ser-536 of p65 and a novel function for this phosphorylation site in the recruitment of components of the basal transcriptional machinery to the interleukin-8 promoter.	Serine	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	231-244
15454116-6	2004	18alpha,beta-GL inhibited IL-8 dose-dependently and inhibited eotaxin 1 slightly.	18alpha	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
15604281-6	2004	Complementary DNA microarray expression profiling allowed us to identify a subset of genes specifically regulated by tamoxifen and CC-8490, and not by other apoptotic stimuli, including nuclear factor (NF)-kappaB with its target genes IEX-3, SOD2, IL6, and IL8.	Tamoxifen	117-126	C-X-C motif chemokine ligand 8	Homo sapiens	257-260
15454116-6	2004	18alpha,beta-GL inhibited IL-8 dose-dependently and inhibited eotaxin 1 slightly.	Glycyrrhizic Acid	8-15	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
15530425-4	2004	METHODS AND RESULTS: AngII-induced upregulation of IL-8 and MCP-1 protein and RNA in monocytes was inhibited by the AT1R-blocker losartan, but not by the AT2R-blocker PD 123.319.	Losartan	129-137	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
15585881-7	2004	Unexpectedly, both ADP and ATP inhibited the generation of TNF-alpha in response to the TLR2 ligand, peptidoglycan, and blocked the production of TNF-alpha, IL-8, and MIP-1beta in response to leukotriene D(4).	Adenosine Diphosphate	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
15585881-7	2004	Unexpectedly, both ADP and ATP inhibited the generation of TNF-alpha in response to the TLR2 ligand, peptidoglycan, and blocked the production of TNF-alpha, IL-8, and MIP-1beta in response to leukotriene D(4).	Adenosine Triphosphate	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
15530425-5	2004	Ramiprilat dose-dependently suppressed AngII-induced upregulation of IL-8 and MCP-1.	ramiprilat	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
15530425-8	2004	In addition, ramiprilat downregulated NF-kappaB activity and thereby reduced the AngII-induced release of IL-8 and MCP-1 in monocytes.	ramiprilat	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
15345720-4	2004	Based on high sequence similarity to the determined structures of the Nogo-receptor ectodomain and the intermolecular complex of the Interleukin-8 ligand (IL8) and the N-terminal peptide of the IL8 receptor (IL8RA), the hypothesis was developed that portions of the intramolecular components, Cysteine-box-2 and Cysteine-box-3, of the GPHR ectodomain interact and localize at the interface between ectodomain and serpentine domain.	Cysteine	293-301	C-X-C motif chemokine ligand 8	Homo sapiens	133-153
15568848-1	2004	Hydroxide adsorption on the (111), (110), and (100) faces of silver electrodes from mixed NaOH/NaF solution is studied using cyclic voltammetry and in situ second harmonic generation (SHG).	hydroxide ion	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
15345720-4	2004	Based on high sequence similarity to the determined structures of the Nogo-receptor ectodomain and the intermolecular complex of the Interleukin-8 ligand (IL8) and the N-terminal peptide of the IL8 receptor (IL8RA), the hypothesis was developed that portions of the intramolecular components, Cysteine-box-2 and Cysteine-box-3, of the GPHR ectodomain interact and localize at the interface between ectodomain and serpentine domain.	Cysteine	293-301	C-X-C motif chemokine ligand 8	Homo sapiens	155-158
15345720-4	2004	Based on high sequence similarity to the determined structures of the Nogo-receptor ectodomain and the intermolecular complex of the Interleukin-8 ligand (IL8) and the N-terminal peptide of the IL8 receptor (IL8RA), the hypothesis was developed that portions of the intramolecular components, Cysteine-box-2 and Cysteine-box-3, of the GPHR ectodomain interact and localize at the interface between ectodomain and serpentine domain.	Cysteine	293-301	C-X-C motif chemokine ligand 8	Homo sapiens	194-197
15345720-4	2004	Based on high sequence similarity to the determined structures of the Nogo-receptor ectodomain and the intermolecular complex of the Interleukin-8 ligand (IL8) and the N-terminal peptide of the IL8 receptor (IL8RA), the hypothesis was developed that portions of the intramolecular components, Cysteine-box-2 and Cysteine-box-3, of the GPHR ectodomain interact and localize at the interface between ectodomain and serpentine domain.	Cysteine	312-320	C-X-C motif chemokine ligand 8	Homo sapiens	133-153
15345720-4	2004	Based on high sequence similarity to the determined structures of the Nogo-receptor ectodomain and the intermolecular complex of the Interleukin-8 ligand (IL8) and the N-terminal peptide of the IL8 receptor (IL8RA), the hypothesis was developed that portions of the intramolecular components, Cysteine-box-2 and Cysteine-box-3, of the GPHR ectodomain interact and localize at the interface between ectodomain and serpentine domain.	Cysteine	312-320	C-X-C motif chemokine ligand 8	Homo sapiens	155-158
15345720-4	2004	Based on high sequence similarity to the determined structures of the Nogo-receptor ectodomain and the intermolecular complex of the Interleukin-8 ligand (IL8) and the N-terminal peptide of the IL8 receptor (IL8RA), the hypothesis was developed that portions of the intramolecular components, Cysteine-box-2 and Cysteine-box-3, of the GPHR ectodomain interact and localize at the interface between ectodomain and serpentine domain.	Cysteine	312-320	C-X-C motif chemokine ligand 8	Homo sapiens	194-197
15577845-10	2004	PGE(2) , EP2, or EP3 agonists reduced TNF-alpha-induced CCL27 secretion and mRNA levels in parallel to NF-kappaB activity and CCL2, CCL5, CXCL8, and CXCL10 mRNA levels.	Prostaglandins E	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	138-143
15731299-9	2004	We present evidence for direct and/or indirect roles of steroid hormones on the expression of chemotactic cytokines (interleukin-8 and monocyte chemotactic protein-1) and on the survival versus apoptosis of resident endometrial cells (stromal, epithelial, and endothelial cells) and nonresident cells (leukocytes).	Steroids	56-72	C-X-C motif chemokine ligand 8	Homo sapiens	117-130
15731315-10	2004	The addition of the anti-inflammatory steroid, dexamethasone, significantly reduced the LPS-mediated increase in levels of IL-8 in SCTs.	Steroids	38-45	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
15731315-10	2004	The addition of the anti-inflammatory steroid, dexamethasone, significantly reduced the LPS-mediated increase in levels of IL-8 in SCTs.	Dexamethasone	47-60	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
15548807-10	2004	CONCLUSION: Plasma levels of IL-8 are elevated during the acute phase of NAION, but not IL-6 and TNF-alpha.	naion	73-78	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
15456740-9	2004	However, H2O2, tumor necrosis factor-alpha (TNF-alpha), and IL-1beta significantly increased NF-kappaB activation and expression of IL-8 compared with control cells.	Hydrogen Peroxide	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
15477226-8	2004	IL-8-induced chemotaxis was inhibited in a sexually dimorphic manner by isoprenaline, which also stimulated release of a mediator from neutrophils that induced chemotaxis, that was inhibited by anti-CXCR2 antibodies.	Isoproterenol	72-84	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15654514-4	2004	RESULTS: HMC-1 produced substantial amounts of GM-CSF and IL-8 and smaller amounts of TNF-alpha, IL-4 and IL-6 after being stimulated with PMA together with A23187.	Tetradecanoylphorbol Acetate	139-142	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
15619426-3	2004	Heat, formalin or protease treatment of F. nucleatum cells attenuated the IL-8 mRNA up-regulation.	Formaldehyde	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
15610518-0	2004	All-trans-retinoic acid induces interleukin-8 via the nuclear factor-kappaB and p38 mitogen-activated protein kinase pathways in normal human keratinocytes.	Tretinoin	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	32-45
15610518-3	2004	To test this hypothesis, we investigated whether all-trans-retinoic acid (ATRA) induced IL-8 production in normal human keratinocytes.	Tretinoin	49-72	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
15610518-3	2004	To test this hypothesis, we investigated whether all-trans-retinoic acid (ATRA) induced IL-8 production in normal human keratinocytes.	Tretinoin	74-78	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
15610518-4	2004	Stimulation with 10(-7) M ATRA enhanced IL-8 mRNA expression and induced IL-8 production.	Tretinoin	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
15610518-4	2004	Stimulation with 10(-7) M ATRA enhanced IL-8 mRNA expression and induced IL-8 production.	Tretinoin	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
15610518-5	2004	We also studied the intracellular signaling mechanisms of ATRA-induced IL-8 production in keratinocytes.	Tretinoin	58-62	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
15610518-7	2004	Introduction of a dominant-negative mutant of IkappaBalpha completely abolished ATRA-induced IL-8 production, which indicates that this process is NF-kappaB-dependent.	Tretinoin	80-84	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
15610518-9	2004	ATRA phosphorylated the p38 MAPK, and SB202180 inhibited ATRA-induced IL-8 production, which indicates that the p38 MAPK is also involved in ATRA-induced IL-8 production.	Tretinoin	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
15610518-9	2004	ATRA phosphorylated the p38 MAPK, and SB202180 inhibited ATRA-induced IL-8 production, which indicates that the p38 MAPK is also involved in ATRA-induced IL-8 production.	sb202180	38-46	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
15610518-9	2004	ATRA phosphorylated the p38 MAPK, and SB202180 inhibited ATRA-induced IL-8 production, which indicates that the p38 MAPK is also involved in ATRA-induced IL-8 production.	sb202180	38-46	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
15610518-9	2004	ATRA phosphorylated the p38 MAPK, and SB202180 inhibited ATRA-induced IL-8 production, which indicates that the p38 MAPK is also involved in ATRA-induced IL-8 production.	Tretinoin	57-61	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
15610518-9	2004	ATRA phosphorylated the p38 MAPK, and SB202180 inhibited ATRA-induced IL-8 production, which indicates that the p38 MAPK is also involved in ATRA-induced IL-8 production.	Tretinoin	57-61	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
15610518-9	2004	ATRA phosphorylated the p38 MAPK, and SB202180 inhibited ATRA-induced IL-8 production, which indicates that the p38 MAPK is also involved in ATRA-induced IL-8 production.	Tretinoin	57-61	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
15610518-9	2004	ATRA phosphorylated the p38 MAPK, and SB202180 inhibited ATRA-induced IL-8 production, which indicates that the p38 MAPK is also involved in ATRA-induced IL-8 production.	Tretinoin	57-61	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
15496610-8	2004	Mutation of the IL-8 promoter NF-kappa B site abolished aspirate-induced IL-8 transcription.	aspirate	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
15610518-10	2004	In summary, ATRA induces IL-8 production in both NF-kappaB- and p38 MAPK-dependent manners in normal human keratinocytes.	Tretinoin	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
15569263-6	2004	Curcumin abrogated Abeta1-40-induced expression of cytokines (TNF-alpha and IL-1beta) and chemokines (MIP-1beta, MCP-1 and IL-8) in both peripheral blood monocytes and THP-1 cells.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
15496610-8	2004	Mutation of the IL-8 promoter NF-kappa B site abolished aspirate-induced IL-8 transcription.	aspirate	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
15528384-4	2004	Moreover, the NF-kappaB inhibitors pyrrolidinedithiocarbamate, dexamethasone, or sulfasalazine were found to prevent CXCL8 production by sPLA(2)-IB in human neutrophils.	pyrrolidine dithiocarbamic acid	35-61	C-X-C motif chemokine ligand 8	Homo sapiens	117-122
15496611-6	2004	IL-1 beta, IL-6, IL-8 and TNF-alpha were significantly associated with lactate/choline in the DGN (p = 0.03, 0.02, 0.03, and 0.01 respectively), but not in the WS (all p &gt; 0.1).	Lactic Acid	71-78	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
15496611-6	2004	IL-1 beta, IL-6, IL-8 and TNF-alpha were significantly associated with lactate/choline in the DGN (p = 0.03, 0.02, 0.03, and 0.01 respectively), but not in the WS (all p &gt; 0.1).	Choline	79-86	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
15545821-1	2004	Several CXC-chemokines, of which interleukin (IL)-8 is the prototype, are potent neutrophil chemotactic and activating cytokines, inducing the secretion of granule proteins and the generation of reactive oxygen intermediates that may cause tissue damage and amplify inflammatory responses.	reactive oxygen intermediates	195-224	C-X-C motif chemokine ligand 8	Homo sapiens	33-51
15355994-10	2004	Importantly, using chromatin immunoprecipitation, we show that impaired interaction between GR and p65 with RU486 leads to reduced recruitment of the GR to the NF-kappaB-responsive region of the interleukin-8 promoter, again in contrast to dexamethasone that significantly increased GR binding.	Dexamethasone	240-253	C-X-C motif chemokine ligand 8	Homo sapiens	195-208
15331599-6	2004	We also studied the results of cPLA2 activation by epidermal growth factor (EGF) and calcium ionophore (A23187) on IL-8 and COX-2 reporter gene activity, mRNA level, and protein synthesis.	Calcium	85-92	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
15331599-6	2004	We also studied the results of cPLA2 activation by epidermal growth factor (EGF) and calcium ionophore (A23187) on IL-8 and COX-2 reporter gene activity, mRNA level, and protein synthesis.	Calcimycin	104-110	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
15331599-9	2004	Methyl arachidonyl fluorophosphate, a cPLA2 inhibitor, inhibited the effect of A23187 and of EGF on both IL-8 and COX-2 reporter gene activity, steady state levels of IL-8 and COX-2 mRNA, and IL-8 and COX-2 protein expression.	(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenyl methyl phosphorofluoridate	0-34	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
15331599-9	2004	Methyl arachidonyl fluorophosphate, a cPLA2 inhibitor, inhibited the effect of A23187 and of EGF on both IL-8 and COX-2 reporter gene activity, steady state levels of IL-8 and COX-2 mRNA, and IL-8 and COX-2 protein expression.	(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenyl methyl phosphorofluoridate	0-34	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
15331599-9	2004	Methyl arachidonyl fluorophosphate, a cPLA2 inhibitor, inhibited the effect of A23187 and of EGF on both IL-8 and COX-2 reporter gene activity, steady state levels of IL-8 and COX-2 mRNA, and IL-8 and COX-2 protein expression.	(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenyl methyl phosphorofluoridate	0-34	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
15331599-9	2004	Methyl arachidonyl fluorophosphate, a cPLA2 inhibitor, inhibited the effect of A23187 and of EGF on both IL-8 and COX-2 reporter gene activity, steady state levels of IL-8 and COX-2 mRNA, and IL-8 and COX-2 protein expression.	Calcimycin	79-85	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
15331599-9	2004	Methyl arachidonyl fluorophosphate, a cPLA2 inhibitor, inhibited the effect of A23187 and of EGF on both IL-8 and COX-2 reporter gene activity, steady state levels of IL-8 and COX-2 mRNA, and IL-8 and COX-2 protein expression.	Calcimycin	79-85	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
15331599-9	2004	Methyl arachidonyl fluorophosphate, a cPLA2 inhibitor, inhibited the effect of A23187 and of EGF on both IL-8 and COX-2 reporter gene activity, steady state levels of IL-8 and COX-2 mRNA, and IL-8 and COX-2 protein expression.	Calcimycin	79-85	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
15331599-10	2004	Small inhibitory RNAs directed against PPAR-gamma1 and -gamma2 blunted the effect of A23187 and of EGF on IL-8 and COX-2 protein expression.	Calcimycin	85-91	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
15331599-11	2004	Moreover small inhibitory RNAs directed against cPLA2 decreased the effect of A23187 and EGF on IL-8 and COX-2 protein expression.	Calcimycin	78-84	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
15476283-5	2004	Curcumin decreased the expression of NF-kappaB-regulated gene products, including cyclooxygenase-2 (as assessed using immunoblot analysis), prostaglandin E2, and interleukin-8 (as assessed using an enzyme-linked immunoassay), all of which have been implicated in the growth and invasiveness of pancreatic carcinoma.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	162-175
15584975-3	2004	For instance, elevated seric levels of IL-8 are a common feature in DHF patients.	seric	23-28	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
15364949-6	2004	ROS could indeed be detected in IL-8-stimulated beta-arrestin 1/2 knockout cells, and cytoplasmic Rac was translocated to the membrane fraction, which is a prerequisite for oxidant formation.	ros	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
15364949-7	2004	The oxidative burst induced cell death within 6 h of IL-8 stimulation of these cells, which could be prevented in the presence of DPI.	diphenyleneiodonium	130-133	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
15528377-7	2004	Ethanol, at concentrations within the range found in human blood after acute exposure and below the levels that induce cytotoxicity (0.1-0.5%), did not induce endothelial cell activation, but significantly inhibited TNF-mediated endothelial cell activation, as measured by adhesion molecule (E-selectin, ICAM-1, VCAM-1) expression and chemokine (IL-8, MCP-1, RANTES) production and leukocyte adhesion in vitro.	Ethanol	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	346-350
15528384-4	2004	Moreover, the NF-kappaB inhibitors pyrrolidinedithiocarbamate, dexamethasone, or sulfasalazine were found to prevent CXCL8 production by sPLA(2)-IB in human neutrophils.	Dexamethasone	63-76	C-X-C motif chemokine ligand 8	Homo sapiens	117-122
15528384-4	2004	Moreover, the NF-kappaB inhibitors pyrrolidinedithiocarbamate, dexamethasone, or sulfasalazine were found to prevent CXCL8 production by sPLA(2)-IB in human neutrophils.	Sulfasalazine	81-94	C-X-C motif chemokine ligand 8	Homo sapiens	117-122
15586558-6	2004	Macrolides inhibit the production of many proinflammatory cytokines, such as interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor-alpha, perhaps by suppressing the transcription factor nuclear factor-kappaB or activator protein-1.	Macrolides	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	103-140
15586558-7	2004	Inhibition of cytokine production has been seen in vitro and also in bronchoalveolar lavage fluid, which contains less IL-8 and fewer neutrophils after treatment with macrolides.	Macrolides	167-177	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
15528909-1	2004	The objective of this research was to evaluate the anticaries effectiveness of a low-dose (500 ppm F, low-NaF) sodium fluoride dentifrice, a high-dose (2,800 ppm F, high-NaF) sodium fluoride dentifrice and an experimental 0.454% stabilized stannous fluoride (1,100 ppm F) with sodium hexametaphosphate (SnF2-HMP) dentifrice, each relative to a standard 1,100 ppm F sodium fluoride positive control dentifrice.	Sodium Fluoride	175-190	C-X-C motif chemokine ligand 8	Homo sapiens	170-173
15525462-0	2004	Homocysteine induces production of monocyte chemoattractant protein-1 and interleukin-8 in cultured human whole blood.	Homocysteine	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
15525462-1	2004	AIM: To investigate whether increased plasma L-homocysteine (Hcy) level could promote monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured whole blood.	Homocysteine	45-59	C-X-C motif chemokine ligand 8	Homo sapiens	133-146
15525462-1	2004	AIM: To investigate whether increased plasma L-homocysteine (Hcy) level could promote monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured whole blood.	Homocysteine	45-59	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
15525462-1	2004	AIM: To investigate whether increased plasma L-homocysteine (Hcy) level could promote monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured whole blood.	Homocysteine	61-64	C-X-C motif chemokine ligand 8	Homo sapiens	133-146
15525462-1	2004	AIM: To investigate whether increased plasma L-homocysteine (Hcy) level could promote monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured whole blood.	Homocysteine	61-64	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
15525462-8	2004	radicals, play extremely important role in the Hcy-induced MCP-1 and IL-8 production.	Homocysteine	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
15525462-9	2004	CONCLUSION: Increased Hcy level in plasma (hyperhomocysteinemia) induced MCP-1 and IL-8 secretion in cultured human whole blood, especially in monocytes via oxidative stress mechanism.	Homocysteine	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
15502050-3	2004	We investigated the hypothesis that preincisional IV pentoxifylline (PTX) treatment could attenuate the release of proinflammatory (tumor necrosis factor, interleukin (IL)-1beta, IL-6, and IL-8) and antiinflammatory (IL-1 receptor antagonist) cytokines in patients who underwent elective colorectal cancer surgery.	Pentoxifylline	53-67	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
15502050-3	2004	We investigated the hypothesis that preincisional IV pentoxifylline (PTX) treatment could attenuate the release of proinflammatory (tumor necrosis factor, interleukin (IL)-1beta, IL-6, and IL-8) and antiinflammatory (IL-1 receptor antagonist) cytokines in patients who underwent elective colorectal cancer surgery.	Pentoxifylline	69-72	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
15528909-1	2004	The objective of this research was to evaluate the anticaries effectiveness of a low-dose (500 ppm F, low-NaF) sodium fluoride dentifrice, a high-dose (2,800 ppm F, high-NaF) sodium fluoride dentifrice and an experimental 0.454% stabilized stannous fluoride (1,100 ppm F) with sodium hexametaphosphate (SnF2-HMP) dentifrice, each relative to a standard 1,100 ppm F sodium fluoride positive control dentifrice.	Sodium Fluoride	175-190	C-X-C motif chemokine ligand 8	Homo sapiens	170-173
15550066-5	2004	Effects of PD98059, SB202190 and SP600125 (inhibitors of ERK, p38 and JNK, respectively) on IL-1beta-induced secretion of IL-6 and IL-8, and on IL-1beta-induced expression of cyclo-oxygenase-2 (COX-2) in endometriotic cells were studied.	pyrazolanthrone	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
15550066-8	2004	Both SB202190 and SP600125 suppressed IL-1beta-induced secretion of IL-6 and IL-8, and PD98059 suppressed IL-1beta-induced secretion of IL-8.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	5-13	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
15550066-8	2004	Both SB202190 and SP600125 suppressed IL-1beta-induced secretion of IL-6 and IL-8, and PD98059 suppressed IL-1beta-induced secretion of IL-8.	pyrazolanthrone	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
15550066-8	2004	Both SB202190 and SP600125 suppressed IL-1beta-induced secretion of IL-6 and IL-8, and PD98059 suppressed IL-1beta-induced secretion of IL-8.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	87-94	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
15458513-5	2004	RESULTS: Increased interleukin 1beta (IL1beta) and IL8 release by in vitro cultured normal PBMC was observed after stimulation with LTA at concentrations &gt; or =5 microg/mL; these levels were lower than for lipopolysaccharide (LPS)-stimulated cells and LTA antagonized LPS-induced cytokine release by normal PBMC.	lipoteichoic acid	132-135	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
15544591-8	2004	There was a significant increase in CysLT(1) and BLT(1) receptor expression, as well as a release of LTB(4) and IL-8 after exposure to isocyanates compared with the baseline, only in subjects with isocyanate-induced asthma, whereas there was no increase in LTC(4).	Isocyanates	135-145	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
15519527-4	2004	Treatment with the mitogen-activated protein kinase/extracellular signal-related kinase (MEK) inhibitor U0126 reduced expression of VEGF and IL-8 in MDA-MB-231 cells, partially inhibited expression in MDA-MB-468 and Hs578T cells, with minimal effects in GI101A cells.	U 0126	104-109	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
15491751-2	2004	Here, we investigate a second mechanism in which LPA enhances cellular invasion through the increased expression of IL-8, independent of the expression or activation of MMP2.	lysophosphatidic acid	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
15491751-0	2004	Lysophosphatidic acid enhances epithelial ovarian carcinoma invasion through the increased expression of interleukin-8.	lysophosphatidic acid	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	105-118
15546258-10	2004	The increase in IL-8 was accompanied by a parallel increase in cyclic adenosine monophosphate.	Cyclic AMP	63-93	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
15546258-12	2004	The transient increase in the levels of IL-8 concurs with the results of recent experimental research showing a calcitonin gene-related peptide-induced activation of IL-8 gene expression, but not RANTES and MCP-1, via the transcriptional factor AP-2, which mediates transduction in response to cyclic adenosine monophosphate.	Cyclic AMP	294-324	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
15546258-12	2004	The transient increase in the levels of IL-8 concurs with the results of recent experimental research showing a calcitonin gene-related peptide-induced activation of IL-8 gene expression, but not RANTES and MCP-1, via the transcriptional factor AP-2, which mediates transduction in response to cyclic adenosine monophosphate.	Cyclic AMP	294-324	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
15491751-3	2004	METHODS: Epithelial ovarian carcinoma cells (DOV 13) were exposed to LPA (80 microM) and IL-8 (100 ng/ml) for 24 h. IL-8 expression was quantified by enzyme-linked immunosorbent assay (ELISA).	lysophosphatidic acid	69-72	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
15491751-7	2004	RESULTS: Our results found LPA to increase IL-8 expression threefold.	lysophosphatidic acid	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
15726915-15	2004	In addition, serum level of IL-8 were significantly correlated with the serum levels of HDL-cholesterol, total cholesterol and BMI in pre-eclamptic women (r= 0.368, p &lt; 0.05; r=0.513, p &lt; 0.01 and r= -0.41, p &lt; 0.01, respectively).	Cholesterol	92-103	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
15726915-15	2004	In addition, serum level of IL-8 were significantly correlated with the serum levels of HDL-cholesterol, total cholesterol and BMI in pre-eclamptic women (r= 0.368, p &lt; 0.05; r=0.513, p &lt; 0.01 and r= -0.41, p &lt; 0.01, respectively).	Cholesterol	111-122	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
15514602-10	2004	RESULTS: Suberoylanilide hydroxamic acid significantly enhanced interleukin 8 and nuclear factor kappaB-dependent reporter gene transcription, and these effects were inhibited by bortezomib ( P &lt; or = .01).	Vorinostat	9-40	C-X-C motif chemokine ligand 8	Homo sapiens	64-122
15485475-9	2004	Circulating MCP-1 and IL-8 levels rose after the methionine load (P &lt; 0.001), but not after placebo or methionine plus vitamins.	Methionine	49-59	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
15501764-10	2004	In this regard, the ability of LT-IIbB to activate NF-kappaB and induce TNF-alpha and IL-8 was antagonized by the LT-IIb holotoxin.	stichoposide	121-130	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
15334663-0	2004	Characterization of the biological activities of uridine diphosphate in human dendritic cells: Influence on chemotaxis and CXCL8 release.	Uridine Diphosphate	49-68	C-X-C motif chemokine ligand 8	Homo sapiens	123-128
15334663-8	2004	Instead, UDP, but not UTP, stimulated the release of the CXC-chemokine 8 (CXCL8) from mature DC in a reactive blue sensitive manner.	Uridine Diphosphate	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	74-79
15334663-9	2004	Moreover, our study indicates that UDP stimulates different signaling pathways in immature and mature DC in order to favor the accumulation of immature DC and to augment the capacity to secrete CXCL8 in mature DC.	Uridine Diphosphate	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	194-199
15622447-0	2004	Hyperforin, the active component of St. John"s wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-kappaB-independent pathway.	hyperforin	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
15622447-2	2004	Although St. John"s wort has been reported to have minimal side effects compared with other antidepressants, here we show that hyperforin, the active component of St. John"s wort, can stimulate interleukin-8 (IL-8) expression in human intestinal epithelia cells (IEC) and primary hepatocytes.	hyperforin	127-137	C-X-C motif chemokine ligand 8	Homo sapiens	194-207
15622447-2	2004	Although St. John"s wort has been reported to have minimal side effects compared with other antidepressants, here we show that hyperforin, the active component of St. John"s wort, can stimulate interleukin-8 (IL-8) expression in human intestinal epithelia cells (IEC) and primary hepatocytes.	hyperforin	127-137	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
15622447-5	2004	Although hyperforin is a potent ligand for the steroid and xenobiotic receptor (SXR), we found that hyperforin induced IL-8 mRNA through an SXR-independent transcriptional activation pathway.	hyperforin	100-110	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
15514602-10	2004	RESULTS: Suberoylanilide hydroxamic acid significantly enhanced interleukin 8 and nuclear factor kappaB-dependent reporter gene transcription, and these effects were inhibited by bortezomib ( P &lt; or = .01).	Bortezomib	179-189	C-X-C motif chemokine ligand 8	Homo sapiens	64-122
15507849-5	2004	RESULTS: Urinary IL-6 and IL-8 levels [IL-6, IL-8/creatinine (pg/mg)] were significantly higher in group I than in group II (Il-6 level: 39.4+/-41.1 vs. 6.3+/-13.7, p&lt;0.01; IL-8 level: 791.1+/-1143.6 vs. 36+/-87.9, p&lt;0.001).	Creatinine	50-60	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
15247267-7	2004	Furthermore, inhibition of the EGF receptor by AG1478 significantly reduced NT-induced IL-8 promoter activity and IL-8 secretion.	RTKI cpd	47-53	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
15622447-6	2004	IL-8 induction by hyperforin required the activation of AP-1 but not the NF-kappaB transcription factor, thereby distinguishing it from the NF-kappaB-dependent IL-8 induction mediated by tumor necrosis factor alpha (TNFalpha).	hyperforin	18-28	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15622447-7	2004	Further study revealed that extracellular signal-regulated kinase 1 and 2 (ERK1/2) were required for the hyperforin-induced expression of IL-8.	hyperforin	105-115	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
15369845-4	2004	In addition, production of IL-8 in the U937 cell line increased up to eight-fold at levels of DON just lower than the most toxic one, suggesting that IL-8 can be used as an additional index for cytotoxicity in mononuclear phagocytes.	deoxynivalenol	94-97	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
15369845-4	2004	In addition, production of IL-8 in the U937 cell line increased up to eight-fold at levels of DON just lower than the most toxic one, suggesting that IL-8 can be used as an additional index for cytotoxicity in mononuclear phagocytes.	deoxynivalenol	94-97	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
15627874-8	2004	However, there was a significantly positive correlation between BALF IL-8 and nitrite levels in patients with CF (r = 0.5) and also in control patients (r = 0.6).	Nitrites	78-85	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
15464826-4	2004	Furthermore, it is not known if the previously demonstrated effects on basal and dust-induced IL-6 and IL-8 protein production by 8-bromo-cyclicAMP are time-dependent, since only cumulative effects are observed by measurement of cytokine release.	8-Bromo Cyclic Adenosine Monophosphate	130-147	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
15464826-8	2004	At 1-1.5 h, 8-bromo-cAMP stimulated basal and dust-induced IL-6 mRNA expression and attenuated dust-induced IL-8 mRNA expression by activation of protein kinase A- (PKA), as assessed with the PKA inhibitor H-89.	8-Bromo Cyclic Adenosine Monophosphate	12-24	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
15464826-9	2004	On prolonged exposure (&gt;3 h), the dust-induced IL-6 mRNA was PKA-dependently decreased, whereas at 17 h and longer the IL-8 mRNA expression induced by a dust-suspension with 8-bromo-cAMP was similar to, or enhanced, relative to the dust-induced IL-8 mRNA.	8-Bromo Cyclic Adenosine Monophosphate	177-189	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
15464826-10	2004	Thus, 8-bromo-cAMP exerted opposite action on dust-induced IL-6 and IL-8 mRNA expression with time.	8-Bromo Cyclic Adenosine Monophosphate	6-18	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
15388640-1	2004	Oxidized phospholipids, including oxidation products of palmitoyl-arachidonyl-phosphatidyl choline (PAPC), are mediators of inflammation in endothelial cells (ECs) and known to induce several chemokines, including interleukin-8 (IL-8).	Phospholipids	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	214-227
15247267-7	2004	Furthermore, inhibition of the EGF receptor by AG1478 significantly reduced NT-induced IL-8 promoter activity and IL-8 secretion.	RTKI cpd	47-53	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
15388640-1	2004	Oxidized phospholipids, including oxidation products of palmitoyl-arachidonyl-phosphatidyl choline (PAPC), are mediators of inflammation in endothelial cells (ECs) and known to induce several chemokines, including interleukin-8 (IL-8).	Phospholipids	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	229-233
15388640-7	2004	Furthermore, cholesterol loading of ECs by either the cholesterol-cyclodextrin complex or caveolin-1 overexpression inhibited OxPAPC induction of IL-8.	Cholesterol	54-65	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
15388640-7	2004	Furthermore, cholesterol loading of ECs by either the cholesterol-cyclodextrin complex or caveolin-1 overexpression inhibited OxPAPC induction of IL-8.	Cyclodextrins	66-78	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
15388640-8	2004	These observations suggest that changes in cholesterol level can modulate IL-8 synthesis in ECs.	Cholesterol	43-54	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
15388640-1	2004	Oxidized phospholipids, including oxidation products of palmitoyl-arachidonyl-phosphatidyl choline (PAPC), are mediators of inflammation in endothelial cells (ECs) and known to induce several chemokines, including interleukin-8 (IL-8).	palmitoyl-arachidonyl-phosphatidyl choline	56-98	C-X-C motif chemokine ligand 8	Homo sapiens	214-227
15388640-1	2004	Oxidized phospholipids, including oxidation products of palmitoyl-arachidonyl-phosphatidyl choline (PAPC), are mediators of inflammation in endothelial cells (ECs) and known to induce several chemokines, including interleukin-8 (IL-8).	palmitoyl-arachidonyl-phosphatidyl choline	56-98	C-X-C motif chemokine ligand 8	Homo sapiens	229-233
15388640-1	2004	Oxidized phospholipids, including oxidation products of palmitoyl-arachidonyl-phosphatidyl choline (PAPC), are mediators of inflammation in endothelial cells (ECs) and known to induce several chemokines, including interleukin-8 (IL-8).	PAPC	100-104	C-X-C motif chemokine ligand 8	Homo sapiens	214-227
15388640-1	2004	Oxidized phospholipids, including oxidation products of palmitoyl-arachidonyl-phosphatidyl choline (PAPC), are mediators of inflammation in endothelial cells (ECs) and known to induce several chemokines, including interleukin-8 (IL-8).	PAPC	100-104	C-X-C motif chemokine ligand 8	Homo sapiens	229-233
15388640-5	2004	We also provide evidence that cholesterol depletion and SREBP activation are signals for OxPAPC induction of IL-8.	Cholesterol	30-41	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
15388640-6	2004	Cholesterol depletion by methyl-beta-cyclodextrin induced IL-8 synthesis in a dose-dependent manner.	Cholesterol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
15388640-6	2004	Cholesterol depletion by methyl-beta-cyclodextrin induced IL-8 synthesis in a dose-dependent manner.	methyl-beta-cyclodextrin	25-49	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
15388640-10	2004	Overexpression of either dominant-negative SREBP cleavage-activating protein or 25-hydroxycholesterol significantly suppressed the effect of OxPAPC on IL-8 transcription.	Hydroxycholesterols	83-101	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
15354211-10	2004	However, the magnitude of IL-8 secretion induced by cytochalasin cannot be accounted for by integrin signalling and may reflect the influence of another signalling pathway or a novel, intrinsic cytoskeletal function.	Cytochalasins	52-64	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
15586939-0	2004	Stimulation of endothelial IL-8 (eIL-8) production and apoptosis by phenolic metabolites of benzene in HL-60 cells and human bone marrow endothelial cells.	Benzene	92-99	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
15586939-2	2004	One potential mechanism of apoptosis induced by benzene metabolites that has not been examined is the production of pro-apoptotic cytokines such as endothelial IL-8 from endothelial cells in bone marrow stroma.	Benzene	48-55	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
15388640-7	2004	Furthermore, cholesterol loading of ECs by either the cholesterol-cyclodextrin complex or caveolin-1 overexpression inhibited OxPAPC induction of IL-8.	Cholesterol	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
15483420-3	2004	We determined the effects of theaflavin, a black tea-derived polyphenol, on tumor necrosis factor-alpha-mediated expression of the interleukin-8 gene in A549 cells.	theaflavin	29-39	C-X-C motif chemokine ligand 8	Homo sapiens	131-144
15180920-4	2004	Resveratrol and the related molecule quercetin, but not deoxyrhapontin, inhibited IL-8 and granulocyte-macrophage colony-stimulating factor release from A549 cells.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	82-147
15180920-4	2004	Resveratrol and the related molecule quercetin, but not deoxyrhapontin, inhibited IL-8 and granulocyte-macrophage colony-stimulating factor release from A549 cells.	Quercetin	37-46	C-X-C motif chemokine ligand 8	Homo sapiens	82-147
15308550-9	2004	Exogenous ADMA also stimulated secretion of MCP-1 and interleukin-8.	N,N-dimethylarginine	10-14	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
15344968-9	2004	In the LTX group, total cell counts, neutrophil percentages and IL-8 levels were much higher in SI than BAL (1.6 x 10(6)/mL, 65.5% and 54.2 ng/mL vs. 0.1 x 10(6)/mL, 3.0% and 0.01 ng/mL; p &lt; 0.001).	Leukotriene C4	7-10	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
15169673-0	2004	Nitric oxide increases IL-8 gene transcription and mRNA stability to enhance IL-8 gene expression in lung epithelial cells.	Nitric Oxide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
15169673-0	2004	Nitric oxide increases IL-8 gene transcription and mRNA stability to enhance IL-8 gene expression in lung epithelial cells.	Nitric Oxide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
15169673-3	2004	The association between elevated levels of nitric oxide (NO) and IL-8 in acute lung injury associated with sepsis, acute respiratory distress syndrome, respiratory syncytial virus infection in infants, and other inflammatory diseases suggested that NO may play important roles in the control of IL-8 gene expression in the lung.	Nitric Oxide	43-55	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
15169673-3	2004	The association between elevated levels of nitric oxide (NO) and IL-8 in acute lung injury associated with sepsis, acute respiratory distress syndrome, respiratory syncytial virus infection in infants, and other inflammatory diseases suggested that NO may play important roles in the control of IL-8 gene expression in the lung.	Nitric Oxide	43-55	C-X-C motif chemokine ligand 8	Homo sapiens	295-299
15169673-9	2004	NO induction of IL-8 mRNA was significantly reduced by inhibitors of extracellular regulated kinase and protein kinase C. IL-8 induction by NO was also reduced by hydroxyl radical scavengers such as dimethyl sulfoxide and dimethylthiourea, indicating the involvement of hydroxyl radicals in the induction process.	Hydroxyl Radical	163-179	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
15169673-9	2004	NO induction of IL-8 mRNA was significantly reduced by inhibitors of extracellular regulated kinase and protein kinase C. IL-8 induction by NO was also reduced by hydroxyl radical scavengers such as dimethyl sulfoxide and dimethylthiourea, indicating the involvement of hydroxyl radicals in the induction process.	Hydroxyl Radical	163-179	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
15169673-9	2004	NO induction of IL-8 mRNA was significantly reduced by inhibitors of extracellular regulated kinase and protein kinase C. IL-8 induction by NO was also reduced by hydroxyl radical scavengers such as dimethyl sulfoxide and dimethylthiourea, indicating the involvement of hydroxyl radicals in the induction process.	Dimethyl Sulfoxide	199-217	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
15169673-9	2004	NO induction of IL-8 mRNA was significantly reduced by inhibitors of extracellular regulated kinase and protein kinase C. IL-8 induction by NO was also reduced by hydroxyl radical scavengers such as dimethyl sulfoxide and dimethylthiourea, indicating the involvement of hydroxyl radicals in the induction process.	Dimethyl Sulfoxide	199-217	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
15169673-9	2004	NO induction of IL-8 mRNA was significantly reduced by inhibitors of extracellular regulated kinase and protein kinase C. IL-8 induction by NO was also reduced by hydroxyl radical scavengers such as dimethyl sulfoxide and dimethylthiourea, indicating the involvement of hydroxyl radicals in the induction process.	1,3-dimethylthiourea	222-238	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
15169673-9	2004	NO induction of IL-8 mRNA was significantly reduced by inhibitors of extracellular regulated kinase and protein kinase C. IL-8 induction by NO was also reduced by hydroxyl radical scavengers such as dimethyl sulfoxide and dimethylthiourea, indicating the involvement of hydroxyl radicals in the induction process.	1,3-dimethylthiourea	222-238	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
15169673-9	2004	NO induction of IL-8 mRNA was significantly reduced by inhibitors of extracellular regulated kinase and protein kinase C. IL-8 induction by NO was also reduced by hydroxyl radical scavengers such as dimethyl sulfoxide and dimethylthiourea, indicating the involvement of hydroxyl radicals in the induction process.	Hydroxyl Radical	270-287	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
15169673-9	2004	NO induction of IL-8 mRNA was significantly reduced by inhibitors of extracellular regulated kinase and protein kinase C. IL-8 induction by NO was also reduced by hydroxyl radical scavengers such as dimethyl sulfoxide and dimethylthiourea, indicating the involvement of hydroxyl radicals in the induction process.	Hydroxyl Radical	270-287	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
15476228-15	2004	Methotrexate reduced synovial IL-1alpha, IL-1beta, IL-8, IL-10, IL-15, IFNgamma, and TNFalpha mRNA expression, but the effect was significant only for IL-8.	Methotrexate	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
15476228-15	2004	Methotrexate reduced synovial IL-1alpha, IL-1beta, IL-8, IL-10, IL-15, IFNgamma, and TNFalpha mRNA expression, but the effect was significant only for IL-8.	Methotrexate	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
15476228-16	2004	CONCLUSION: Methotrexate produced a clinical response in PsA by reducing, but not abolishing, the inflammatory infiltrate, adhesion molecule expression, and MMP-3 and proinflammatory cytokine gene expression, particularly IL-8, in the synovium.	Methotrexate	12-24	C-X-C motif chemokine ligand 8	Homo sapiens	222-226
15380914-6	2004	RESULTS: Allicin markedly inhibited the spontaneous and TNF-alpha -induced secretion of IL-1beta, IL-8, IP-10 and MIG from the two different cell lines in a dose-dependent manner and suppressed the expression of IL-8 and IL-1beta mRNA levels.	allicin	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
15380914-6	2004	RESULTS: Allicin markedly inhibited the spontaneous and TNF-alpha -induced secretion of IL-1beta, IL-8, IP-10 and MIG from the two different cell lines in a dose-dependent manner and suppressed the expression of IL-8 and IL-1beta mRNA levels.	allicin	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	212-216
15302455-6	2004	The discs were subjected to 1 min exposures of 0.2% sodium fluoride (NaF); the F re-release was assessed for another 12 h. RESULTS: Following a brief initial burst of F release, the rate decreased rapidly.	Sodium Fluoride	52-67	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
15302455-12	2004	After sodium fluoride (NaF) treatment, F can be recharged easily and re-released rapidly within 90 min.	Sodium Fluoride	6-21	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
15483420-8	2004	MEASUREMENTS AND MAIN RESULTS: Theaflavin inhibited tumor necrosis factor-alpha-mediated interleukin-8 gene expression, as measured by luciferase assay and Northern blot analysis, at concentrations of 10 and 30 microg/mL.	theaflavin	31-41	C-X-C motif chemokine ligand 8	Homo sapiens	89-102
15483420-9	2004	This effect appears to primarily involve inhibition of interleukin-8 transcription because theaflavin inhibited tumor necrosis factor-alpha-mediated activation of the interleukin-8 promoter in cells transiently transfected with an interleukin-8 promoter-luciferase reporter plasmid.	theaflavin	91-101	C-X-C motif chemokine ligand 8	Homo sapiens	55-68
15483420-9	2004	This effect appears to primarily involve inhibition of interleukin-8 transcription because theaflavin inhibited tumor necrosis factor-alpha-mediated activation of the interleukin-8 promoter in cells transiently transfected with an interleukin-8 promoter-luciferase reporter plasmid.	theaflavin	91-101	C-X-C motif chemokine ligand 8	Homo sapiens	167-180
15483420-9	2004	This effect appears to primarily involve inhibition of interleukin-8 transcription because theaflavin inhibited tumor necrosis factor-alpha-mediated activation of the interleukin-8 promoter in cells transiently transfected with an interleukin-8 promoter-luciferase reporter plasmid.	theaflavin	91-101	C-X-C motif chemokine ligand 8	Homo sapiens	167-180
15483420-12	2004	CONCLUSIONS: We conclude that theaflavin is a potent inhibitor of interleukin-8 gene expression in vitro.	theaflavin	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
15474071-9	2004	Production of both IL-8 and M-CSF was statistically significantly increased by IL-1alpha plus C6-ceramide as compared with IL-1alpha alone; however, IL-6 production was not increased.	N-caproylsphingosine	94-105	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
15364099-9	2004	ASBG affected the production of IL-8 by human peripheral blood mononuclear cells (PBMC).	asbg	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
15474070-6	2004	MAIN OUTCOME MEASURE(S): We determined the effect of LPS on the production of TNFalpha and IL-8 and the effect of IL-8 antisense oligonucleotide and nuclear factor-kappaB (NF-kappaB) inhibitor on IL-8 production using ELISA.	Oligonucleotides	129-144	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
15474070-6	2004	MAIN OUTCOME MEASURE(S): We determined the effect of LPS on the production of TNFalpha and IL-8 and the effect of IL-8 antisense oligonucleotide and nuclear factor-kappaB (NF-kappaB) inhibitor on IL-8 production using ELISA.	Oligonucleotides	129-144	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
15474070-12	2004	IL-8 antisense oligonucleotide and NF-kappaB inhibitor significantly decreased LPS-induced IL-8 protein production and LPS-induced ESC proliferation.	Oligonucleotides	15-30	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15474071-10	2004	CONCLUSION(S): The results suggest that IL-1alpha stimulates the production of IL-8 and M-CSF by a mechanism that involves the sphingomyelin-ceramide system.	Sphingomyelins	127-140	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
15474070-12	2004	IL-8 antisense oligonucleotide and NF-kappaB inhibitor significantly decreased LPS-induced IL-8 protein production and LPS-induced ESC proliferation.	Oligonucleotides	15-30	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
15474071-0	2004	Synergistic effect of interleukin (IL)-1alpha and ceramide analogue on the production of IL-6, IL-8, and macrophage colony-stimulating factor by endometrial stromal cells.	Ceramides	50-58	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
15474071-10	2004	CONCLUSION(S): The results suggest that IL-1alpha stimulates the production of IL-8 and M-CSF by a mechanism that involves the sphingomyelin-ceramide system.	Ceramides	141-149	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
15474071-2	2004	DESIGN: The effects of IL-1alpha, IL-1 receptor antagonist (IL-1RA), C2-ceramide, and C6-ceramide on the production of IL-6, IL-8, and M-CSF by ESC.	N-acetylsphingosine	69-80	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
15474071-11	2004	Ceramide may be important in increasing the production of IL-8 and M-CSF in the human endometrium.	Ceramides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
16134003-5	2004	GD (0.01-1 mg/mL)-containing medium in stimulated culture supernatants dose-dependently and significantly decreased IL-8, IL-13, and tumor necrosis factor-alpha secretion on the phorbol 12-myristate 13-acetate and A23187-stimulated HMC-1.	Gadolinium	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
15385484-10	2004	Induction of IL-8 mRNA expression occurs rapidly and ceases by 6 h after BFT treatment, whereas IL-8 secretion continues to increase for at least 18 h. Our data suggest that BFT-stimulated IL-8 secretion involves tyrosine kinase-dependent activation of nuclear factor-kappaB (NF-kappaB) as well as activation of the mitogen-activated protein kinases (MAPKs), p38 and extracellular signal-related kinase.	SCHEMBL13664687	73-76	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
15385484-10	2004	Induction of IL-8 mRNA expression occurs rapidly and ceases by 6 h after BFT treatment, whereas IL-8 secretion continues to increase for at least 18 h. Our data suggest that BFT-stimulated IL-8 secretion involves tyrosine kinase-dependent activation of nuclear factor-kappaB (NF-kappaB) as well as activation of the mitogen-activated protein kinases (MAPKs), p38 and extracellular signal-related kinase.	SCHEMBL13664687	174-177	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
15385484-10	2004	Induction of IL-8 mRNA expression occurs rapidly and ceases by 6 h after BFT treatment, whereas IL-8 secretion continues to increase for at least 18 h. Our data suggest that BFT-stimulated IL-8 secretion involves tyrosine kinase-dependent activation of nuclear factor-kappaB (NF-kappaB) as well as activation of the mitogen-activated protein kinases (MAPKs), p38 and extracellular signal-related kinase.	SCHEMBL13664687	174-177	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
15385484-10	2004	Induction of IL-8 mRNA expression occurs rapidly and ceases by 6 h after BFT treatment, whereas IL-8 secretion continues to increase for at least 18 h. Our data suggest that BFT-stimulated IL-8 secretion involves tyrosine kinase-dependent activation of nuclear factor-kappaB (NF-kappaB) as well as activation of the mitogen-activated protein kinases (MAPKs), p38 and extracellular signal-related kinase.	SCHEMBL13664687	174-177	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
15385484-11	2004	Simultaneous activation of NF-kappaB and MAPKs appears necessary for secretion of IL-8 by HT29/C1 cells treated with BFT.	SCHEMBL13664687	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
15326096-6	2004	Pg-LP, as well as Ec-LPS, was potent in inducing IL-8 production in human gingival fibroblasts.	pg-lp	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
15326096-6	2004	Pg-LP, as well as Ec-LPS, was potent in inducing IL-8 production in human gingival fibroblasts.	ec-lps	18-24	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
15219635-6	2004	In analyses adjusting for age, body mass index (BMI), fasting cholesterol, alcohol use, race and 17beta-estradiol (E(2)), higher Ho scores were associated with greater LPS-stimulated expression of IL-1alpha (beta = 0.033, p = 0.02), IL-8 (beta = 0.046, p = 0.01) and IL-1beta (beta = 0.024, p = 0.06).	Estradiol	97-113	C-X-C motif chemokine ligand 8	Homo sapiens	233-237
15377293-5	2004	Although gadolinium chloride treatment did not affect the level of serum TNF-alpha, it significantly reduced that of interleukin (IL)-8 and neutrophil migration in the hepatic sinusoids after the lipopolysaccharide challenge.	gadolinium chloride	9-28	C-X-C motif chemokine ligand 8	Homo sapiens	117-135
15269287-0	2004	Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells.	Sulfasalazine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	146-159
15269287-2	2004	Here, we show that prolonged exposure of human monocytic/macrophage THP1 and U937 cells to sulfasalazine, an anti-inflammatory drug and inhibitor of nuclear factor-kappaB (NF-kappaB), resulted in down-regulation of PD-ECGF/TP and IL-8 (mRNA, protein and activity) along with elimination of their induction by tumor necrosis factor-alpha and interferon-gamma.	Sulfasalazine	91-104	C-X-C motif chemokine ligand 8	Homo sapiens	230-234
15494123-5	2004	IkappaBalphaM inhibited in vitro and in vivo expression of vascular endothelial growth factor (VEGF) and interleukin 8 (IL-8).	ikappabalpham	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	105-118
15494123-5	2004	IkappaBalphaM inhibited in vitro and in vivo expression of vascular endothelial growth factor (VEGF) and interleukin 8 (IL-8).	ikappabalpham	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
15626158-2	2004	Thioglycollate-elicited neutrophils from BALB/c mice failed to respond to vCXCL-1 while retaining the capacity to respond to known murine (Mu) CXCR2 ligands, such as hCXCL8 (IL8) and mCXCL1 (KC).	Thioglycolates	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	166-172
15514524-5	2004	We hypothesize that pRBC transfusion induces increased IL-8 gene expression that is avoided by the use of PolyHb.	polyhb	106-112	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
15514524-10	2004	PolyHb IL-8 mRNA was less than pRBC transfused (p &lt;0.01).	polyhb	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	7-11
15514524-11	2004	In PMNs, simulated transfusion of pRBCs increase IL-8 mRNA (RB=3.17 +/- 1.05 amol/microg total RNA, RB + pRBC=7.60 +/- 1.79 amol/microg total RNA, p &lt;0.01), whereas PolyHb did not (RB + PolyHb=4.53 +/- 1.64 amol/microg total RNA).	Rubidium	35-37	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
15240896-3	2004	Our results show that silica particles induced a concentration- and time-dependent increase in interleukin (IL)-8 release from the human epithelial lung cell line A549.	Silicon Dioxide	22-28	C-X-C motif chemokine ligand 8	Homo sapiens	95-113
15453805-10	2004	We noted a significant elevation of il-8 in men with bone metastases, diagnosed by Tc-99 MDP bone scan, when compared to men with localized disease (Figure 1).	tc-99 mdp	83-92	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
15251176-9	2004	When cells exposed to 200 microM SM were treated with the p38 MAP kinase inhibitor SB203580, the levels of IL-8, IL-6, and TNF-alpha and IL-1beta were significantly decreased when compared with cells that were untreated.	Samarium	33-35	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
15240896-4	2004	The IL-8 induction was significantly attenuated by inhibitors of the mitogen-activated protein kinases (MAPKs), p38 (SB202190) and extracellular signal-regulated kinase (ERK)-1 and -2 (PD98059), as well as a general protein tyrosine kinase (PTK) inhibitor (genistein).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	185-192	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
15251176-9	2004	When cells exposed to 200 microM SM were treated with the p38 MAP kinase inhibitor SB203580, the levels of IL-8, IL-6, and TNF-alpha and IL-1beta were significantly decreased when compared with cells that were untreated.	SB 203580	83-91	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
15240896-4	2004	The IL-8 induction was significantly attenuated by inhibitors of the mitogen-activated protein kinases (MAPKs), p38 (SB202190) and extracellular signal-regulated kinase (ERK)-1 and -2 (PD98059), as well as a general protein tyrosine kinase (PTK) inhibitor (genistein).	Genistein	257-266	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
15240896-5	2004	However, IL-8 induction was most efficiently inhibited by the Src family kinase (SFK) inhibitor, PP2, suggesting a crucial role of SFKs in regulating silica-induced IL-8 release from A549 cells.	Silicon Dioxide	150-156	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
15240896-5	2004	However, IL-8 induction was most efficiently inhibited by the Src family kinase (SFK) inhibitor, PP2, suggesting a crucial role of SFKs in regulating silica-induced IL-8 release from A549 cells.	Silicon Dioxide	150-156	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
15240896-9	2004	Our results suggest the presence of two separate signaling pathways which are important in the regulation of silica-induced IL-8 release from A549 cells; one involving SFK-dependent activation of ERK1/2, and the other activation of p38, at least partly independent of SFKs.	Silicon Dioxide	109-115	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
15251176-2	2004	Previous work has revealed that SM induces the production of inflammatory cytokines, including IL-8, IL-6, TNF-alpha, and IL-1beta, in keratinocytes.	Samarium	32-34	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
15286717-0	2004	Inhibitory effects of cyclosporin A on calcium mobilization-dependent interleukin-8 expression and invasive potential of human glioblastoma U251MG cells.	Calcium	39-46	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
15562785-4	2004	RESULTS: IL-8 and TNF-alpha levels in EPS were higher in men with CBP [(10967.5 +/- 3477.7) pg/ml, (84.1 +/- 54.7) pg/ml] or CPPS IIIA [(9268.4 +/- 2034.6) pg/ml and (32.6 +/- 18.6) pg/ml], but lower in men with CPPS IIIB [(2726.1 +/- 277.5) pg/ml, (12.6 +/- 7.1) pg/ml] or controls [(2800.0 +/- 320.2) pg/ml and (12.9 +/- 10.1) pg/ml] respectively.	exophthalmos producing substance	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
15280372-6	2004	Treatment of HBEpCs with LPA increased both IL-8 gene and protein expression, which was coupled to Gi and G(12/13) proteins.	lysophosphatidic acid	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
15280372-8	2004	Furthermore, LPA-activated PKCdelta and the LPA-mediated activation of NF-kappaB and IL-8 production were attenuated by overexpression of dominant-negative PKCdelta and rottlerin.	lysophosphatidic acid	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
15280372-8	2004	Furthermore, LPA-activated PKCdelta and the LPA-mediated activation of NF-kappaB and IL-8 production were attenuated by overexpression of dominant-negative PKCdelta and rottlerin.	rottlerin	169-178	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
15280372-10	2004	These results demonstrate for the first time that LPA is a potent stimulator of IL-8 production in HBEpCs, which involves PKCdelta/NF-kappaB signaling pathways.	lysophosphatidic acid	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
15364009-4	2004	Benidipine also suppressed induction of monocyte chemoattractant protein (MCP)-1 and interleukin-8.	benidipine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	85-98
15286717-3	2004	Combined treatment with Ca(2+)-ionophore and phorbol-myristate-acetate (A23187/PMA) increased IL-8 mRNA and protein levels.	Tetradecanoylphorbol Acetate	45-70	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
15286717-3	2004	Combined treatment with Ca(2+)-ionophore and phorbol-myristate-acetate (A23187/PMA) increased IL-8 mRNA and protein levels.	Calcimycin	72-78	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
15358661-5	2004	Treatment of T24 and 5637 cells with phosphatidylinositol-specific phospholipase C to eliminate CD14 from the cell surface dramatically suppressed the induction of IL-8.	Phosphatidylinositols	37-57	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
15337792-6	2004	Theophylline induced a sixfold increase in HDAC activity in COPD AM lysates and significantly enhanced dexamethasone suppression of induced IL-8 release, an effect that was blocked by the HDAC inhibitor trichostatin A.	Theophylline	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
15337792-6	2004	Theophylline induced a sixfold increase in HDAC activity in COPD AM lysates and significantly enhanced dexamethasone suppression of induced IL-8 release, an effect that was blocked by the HDAC inhibitor trichostatin A.	Dexamethasone	103-116	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
15337792-6	2004	Theophylline induced a sixfold increase in HDAC activity in COPD AM lysates and significantly enhanced dexamethasone suppression of induced IL-8 release, an effect that was blocked by the HDAC inhibitor trichostatin A.	trichostatin A	203-217	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
15517885-4	2004	Resveratrol has been shown to suppress the activation of several transcription factors, including NF-kappaB, AP-1 and Egr-1; to inhibit protein kinases including IkappaBalpha kinase, JNK, MAPK, Akt, PKC, PKD and casein kinase II; and to down-regulate products of genes such as COX-2, 5-LOX, VEGF, IL-1, IL-6, IL-8, AR and PSA.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	309-313
15302676-7	2004	Repertaxin also prevented CXCL8-induced calcium influx but not CXCL8 binding to purified rat neutrophils.	Calcium	40-47	C-X-C motif chemokine ligand 8	Homo sapiens	26-31
15383152-7	2004	However, IL-6, IL-8, and IL-13 production induced by IL-1 beta were significantly enhanced by addition of epinephrine.	Epinephrine	106-117	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
15117678-6	2004	Expression of IL-1beta, IL-6, IL-8, and COX-2 mRNA was reduced by 30 microM PP1, an Src family tyrosine kinase inhibitor, and by 25 microM SB-203580, a p38 MAPK inhibitor.	SB 203580	139-148	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
15252191-3	2004	OBJECTIVE: To evaluate the antiinflammatory effect of clarithromycin on serum and sputum interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), and leukotriene B4 levels in patients with COPD.	Clarithromycin	54-68	C-X-C motif chemokine ligand 8	Homo sapiens	89-102
15252191-3	2004	OBJECTIVE: To evaluate the antiinflammatory effect of clarithromycin on serum and sputum interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), and leukotriene B4 levels in patients with COPD.	Clarithromycin	54-68	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
15252191-9	2004	After the treatment, the induced sputum total cell counts, and IL-8 and TNF-alpha levels decreased significantly in the clarithromycin group compared with pretreatment levels (mean +/- SD IL-8 1606 +/- 367.3 vs 882 +/- 143.6 pg/mL, p = 0.001; TNF-alpha 638.2 +/- 287.5 vs 390 +/- 235 pg/mL, p = 0.001).	Clarithromycin	120-134	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
15252191-9	2004	After the treatment, the induced sputum total cell counts, and IL-8 and TNF-alpha levels decreased significantly in the clarithromycin group compared with pretreatment levels (mean +/- SD IL-8 1606 +/- 367.3 vs 882 +/- 143.6 pg/mL, p = 0.001; TNF-alpha 638.2 +/- 287.5 vs 390 +/- 235 pg/mL, p = 0.001).	Clarithromycin	120-134	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
15252191-11	2004	CONCLUSIONS: This study demonstrated that the decrease in IL-8 and TNF-alpha levels might be related to the antiinflammatory effect of clarithromycin.	Clarithromycin	135-149	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
15313144-8	2004	IL-8 secretion was not altered by bradykinin or adenosine, but amiloride significantly decreased IL-8 secretion.	Amiloride	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
15178703-6	2004	Moreover, an inhibitory effect of cyclosporin A, an immunosuppressor that inhibits calcineurin activity, on IL-8 release and IL-8 mRNA expression was observed.	Cyclosporine	34-47	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
15352171-2	2004	Therefore, the aim of our study was to investigate, in primary cultures of human bronchial epithelial cells (HBEC), the signal transduction pathways activated by increasing concentrations (0.25, 0.5, and 1 mM) of hydrogen peroxide (H(2)O(2)), as well as their effects on IL-8 production and cell viability.	Hydrogen Peroxide	213-230	C-X-C motif chemokine ligand 8	Homo sapiens	271-275
15352171-3	2004	The reported results show that H(2)O(2) elicited, in a concentration-dependent fashion, a remarkable increase in phosphorylation-dependent activation of mitogen-activated protein kinases (MAPKs), associated with a significant induction of IL-8 synthesis and a dramatically enhanced cell death.	Hydrogen Peroxide	31-39	C-X-C motif chemokine ligand 8	Homo sapiens	239-243
15352171-4	2004	Pre-treatment of HBEC with MAPK inhibitors was able to significantly inhibit the effects of H(2)O(2) on IL-8 secretion, and to effectively prevent cell death.	Hydrogen Peroxide	92-100	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
15381247-0	2004	Antisense phosphorothioate oligonucleotides to NF-kappaB (RelA/NF-kappaB1) decrease interleukin-8 secretion from cultured normal human epidermal keratinocytes.	Phosphorothioate Oligonucleotides	10-43	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
15178703-6	2004	Moreover, an inhibitory effect of cyclosporin A, an immunosuppressor that inhibits calcineurin activity, on IL-8 release and IL-8 mRNA expression was observed.	Cyclosporine	34-47	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
15178703-7	2004	This is the first evidence of the involvement of ROS and calcium/calcineurin in IgE-dependent IL-8 production.	Reactive Oxygen Species	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
15178703-7	2004	This is the first evidence of the involvement of ROS and calcium/calcineurin in IgE-dependent IL-8 production.	Calcium	57-64	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
15381831-5	2004	Among the gangliosides, O-Ac-GD3, GT(1b), GD(1a), GD(1b), GT(1a), and GD3 had potent dose dependent inhibitory effects on adhesion of H. pylori to MKN-45 cells, interleukin-8 production, and vacuole formation induced by H. pylori toxin binding to Vero cells.	o-ac	24-28	C-X-C motif chemokine ligand 8	Homo sapiens	161-174
15208668-0	2004	Interleukin-1beta stimulates IL-8 expression through MAP kinase and ROS signaling in human gastric carcinoma cells.	Reactive Oxygen Species	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
15252057-8	2004	Based on our results, we propose that IL-8 dimerization functions as a negative regulator for the receptor function and as a positive regulator for binding to glycosaminoglycans and that both play a role in the neutrophil recruitment process.	Glycosaminoglycans	159-177	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
15362934-0	2004	Influence of eicosapentaenoic acid, an omega-3 fatty acid, on ultraviolet-B generation of prostaglandin-E2 and proinflammatory cytokines interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-8 in human skin in vivo.	Eicosapentaenoic Acid	13-34	C-X-C motif chemokine ligand 8	Homo sapiens	204-217
15513378-12	2004	Administration of lansoprazole, a proton-pump inhibitor, decreased both IL-8 mRNA and protein levels in the esophageal mucosa.	Lansoprazole	18-30	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
15208668-5	2004	Specific inhibitors of MEK-1 (PD980590) and P38 MAPK (SB203580) were found to suppress the IL-8 expression and the IL-8 promoter activity.	SB 203580	54-62	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
15208668-5	2004	Specific inhibitors of MEK-1 (PD980590) and P38 MAPK (SB203580) were found to suppress the IL-8 expression and the IL-8 promoter activity.	SB 203580	54-62	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
15208668-5	2004	Specific inhibitors of MEK-1 (PD980590) and P38 MAPK (SB203580) were found to suppress the IL-8 expression and the IL-8 promoter activity.	pd980590	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
15208668-8	2004	N-acetyl cysteine (NAC) prevented the IL-1beta-induced ROS production and IL-8 expression.	Acetylcysteine	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
15208668-8	2004	N-acetyl cysteine (NAC) prevented the IL-1beta-induced ROS production and IL-8 expression.	Acetylcysteine	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
15208668-9	2004	In addition, exogenous H2O2 could induce the IL-8 expression.	Hydrogen Peroxide	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
15208668-5	2004	Specific inhibitors of MEK-1 (PD980590) and P38 MAPK (SB203580) were found to suppress the IL-8 expression and the IL-8 promoter activity.	pd980590	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
15208668-14	2004	The above results suggest that MAPK-AP-1 and ROS-NF-kappaB signaling pathways are involved in the IL-1beta-induced IL-8 expression and that these paracrine signaling pathways induce endothelial cell proliferation.	Reactive Oxygen Species	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
15311945-3	2004	We have observed that pretreatment of cells with PTIO boosted expression of IL-8 and heme oxygenase 1 (HOX) genes to a high level in cells treated with the NO donor DPTA-NO.	dpta-no	165-172	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
15311945-5	2004	The effect of PTIO was abrogated by reduced glutathione, suggesting that upregulation of the IL-8 and HOX genes is dependent on RNI-mediated S-nitrosation of specific regulator(s).	Glutathione	44-55	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
15311945-6	2004	The concentration of PTIO required to enhance mRNA level was different for IL-8 and HOX genes.	2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide	21-25	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
15311945-7	2004	Analysis of 4,5-diaminofluorescein (DAF) nitrosation in the presence of PTIO and DPTA-NO showed that optimal PTIO concentrations required for maximal N(2)O(3) synthesis and for highest IL-8 gene expression are similar.	4,5-diaminofluorescein	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
15311945-7	2004	Analysis of 4,5-diaminofluorescein (DAF) nitrosation in the presence of PTIO and DPTA-NO showed that optimal PTIO concentrations required for maximal N(2)O(3) synthesis and for highest IL-8 gene expression are similar.	dpta-no	81-88	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
15478484-1	2004	PURPOSE: To evaluate the effectiveness of a 5% sodium fluoride (NaF) bioerodible gel to remineralize demineralized enamel.	Sodium Fluoride	47-62	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
15356918-0	2004	Stimulation of endothelial IL-8 (eIL-8) production and apoptosis by phenolic metabolites of benzene in HL-60 cells and human bone marrow endothelial cells.	Benzene	92-99	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
15356918-2	2004	One potential mechanism of apoptosis induced by benzene metabolites that has not been examined is the production of pro-apoptotic cytokines such as endothelial IL-8 from endothelial cells in bone marrow stroma.	Benzene	48-55	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
15072962-0	2004	Cytokine gene expression in human skeletal muscle during concentric contraction: evidence that IL-8, like IL-6, is influenced by glycogen availability.	Glycogen	129-137	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
15072962-6	2004	In addition, the fold change for both IL-8 and IL-6 was markedly higher (P &lt; 0.05) in Lo Gly compared with Con.	Glycine	92-95	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
15072962-11	2004	Furthermore, the mRNA abundance of IL-6 and IL-8 appears to be influenced by glycogen availability in the contracting muscle.	Glycogen	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
15271731-2	2004	We investigated the hypothesis that epidural clonidine premedication and postoperative patient-controlled epidural analgesia (PCEA) including clonidine would decrease the release of proinflammatory (interleukin (IL)-6, IL-1beta, IL-8, and tumor necrosis factor (TNF)-alpha) and antiinflammatory (IL-1 receptor antagonist (RA)) cytokines in patients who underwent elective colorectal surgery and that they would provide better postoperative analgesia.	Clonidine	45-54	C-X-C motif chemokine ligand 8	Homo sapiens	229-233
15305018-7	2004	A strong inhibition of the expression of the cytokine IL-8 by cultured neutrophils was also observed; this is discussed with reference to the antioxidant-like property of acetoacetate.	acetoacetic acid	171-183	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
15271731-2	2004	We investigated the hypothesis that epidural clonidine premedication and postoperative patient-controlled epidural analgesia (PCEA) including clonidine would decrease the release of proinflammatory (interleukin (IL)-6, IL-1beta, IL-8, and tumor necrosis factor (TNF)-alpha) and antiinflammatory (IL-1 receptor antagonist (RA)) cytokines in patients who underwent elective colorectal surgery and that they would provide better postoperative analgesia.	Clonidine	142-151	C-X-C motif chemokine ligand 8	Homo sapiens	229-233
15271731-6	2004	For patients in the clonidine group, production of IL-1RA, IL-6, and IL-8 was significantly less increased at the end of the surgical procedure and at 12 and 24 h after surgery.	Clonidine	20-29	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
15283562-5	2004	After reaction with hydrofluoric acid (HF) or fluoride salts (KF, CsF, NaF), its immunoreactivity is restored, and native estradiol is formed and is detected by immunoassay.	Hydrofluoric Acid	20-37	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
15283562-5	2004	After reaction with hydrofluoric acid (HF) or fluoride salts (KF, CsF, NaF), its immunoreactivity is restored, and native estradiol is formed and is detected by immunoassay.	Fluorides	46-60	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
15283562-5	2004	After reaction with hydrofluoric acid (HF) or fluoride salts (KF, CsF, NaF), its immunoreactivity is restored, and native estradiol is formed and is detected by immunoassay.	Estradiol	122-131	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
15302609-6	2004	Urinary IL-8 levels of MIBC patients were significantly increased when compared with the levels of SBC patients and healthy subjects (P &lt; 0.001).	4-METHYL-2-PENTANOL	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	8-12
15297094-0	2004	Glutamine and CXC chemokines IL-8, Mig, IP-10 and I-TAC in human intestinal epithelial cells.	Glutamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
15297094-4	2004	METHODS: The present study aimed to determine the effect of glutamine on the IL-8, Mig, IP-10 and I-TAC production by ELISA and their mRNA level by RT-PCR (expressed as % gapdh) in two human intestinal epithelial cell lines Caco-2/TC7 and HCT-8 under basal conditions or during stimulation with combined cytokines.	Glutamine	60-69	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
15265937-3	2004	We recently reported that heme is a proinflammatory molecule, able to induce neutrophil migration, reactive oxygen species generation, and IL-8 expression.	Heme	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
15259026-2	2004	The transcriptional profile induced by IL-8 in human neutrophils was analyzed using high-density oligonucleotide arrays and compared with that of the prototypic phagocyte activator LPS.	density oligonucleotide	89-112	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
15518173-0	2004	Inhibitory effect of water-soluble chitosan on TNF-alpha and IL-8 secretion from HMC-1 cells.	Water	21-26	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
15518173-3	2004	In this study, we investigated whether pro-inflammatory cytokines (TNF-alpha and IL-8) can be induced by calcium stimulation in HMC-1 cells, and high molecular weight water-soluble chitosan (WSC) can inhibit the production of these cytokines.	Calcium	105-112	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
15297492-0	2004	Alanine-threonine polymorphism of Helicobacter pylori RpoB is correlated with differential induction of interleukin-8 in MKN45 cells.	Alanine	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	104-117
15297492-0	2004	Alanine-threonine polymorphism of Helicobacter pylori RpoB is correlated with differential induction of interleukin-8 in MKN45 cells.	Threonine	8-17	C-X-C motif chemokine ligand 8	Homo sapiens	104-117
15297492-6	2004	RpoB(Thr) strains induced a much larger amount of interleukin-8, a chemokine that plays an important role in chronic inflammation, than RpoB(Ala) strains in cultured MKN45 cells.	Threonine	5-8	C-X-C motif chemokine ligand 8	Homo sapiens	50-63
15518173-4	2004	We provided evidence that the secretion of TNF-alpha and IL-8 from HMC-1 cells was induced by Ca2+-ionophore A23187 or Ca2+-ATPase inhibitor TSG.	Calcimycin	109-115	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
15518173-6	2004	IL-8 secretion in response to A23187 or TSG was inhibited by 49.2% for A23187 and 34.1% for TSG, respectively, compared to absence of WSC.	Calcimycin	30-36	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15518173-6	2004	IL-8 secretion in response to A23187 or TSG was inhibited by 49.2% for A23187 and 34.1% for TSG, respectively, compared to absence of WSC.	Calcimycin	71-77	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15265658-10	2004	Poly I:C treatment of RPE resulted in an increase in the production of IL-6, IL-8, MCP-1, and sICAM-1.	Poly I-C	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
15194816-8	2004	The stretch-induced augmentation of both IL-8 and MCP-3 expression was significantly suppressed by an activator protein-1 (AP-1) inhibitor, curcumin.	Curcumin	140-148	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
15300205-9	2004	RESULTS: beta-glucan significantly enhanced chemotaxis toward C5a and suppressed that toward IL-8 in a CR3-dependent fashion.	beta-Glucans	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
15302158-3	2004	We have shown that stimulation of the human B cell line RPMI 8226 with CpG-ODN 1826 or 2006 results in the activation of IL-8 promoter and nuclear localization of NF-kappaB in the CG sequence- and phosphorothioate backbone modification-dependent manner.	Parathion	197-213	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
15344533-4	2004	The production of IL-8 from esophageal mucosal cells was enhanced by the exposure to bile acid.	Bile Acids and Salts	85-94	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
15258595-3	2004	Dendrimer glucosamine inhibited Toll-like receptor 4-mediated lipopolysaccharide induced synthesis of pro-inflammatory chemokines (MIP-1 alpha, MIP-1 beta, IL-8) and cytokines (TNF-alpha, IL-1 beta, IL-6) from human dendritic cells and macrophages but allowed upregulation of the costimulatory molecules CD25, CD80, CD83 and CD86.	Glucosamine	10-21	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
15181190-2	2004	We have shown that recombinant human IL-8/CXCL8 (rhIL-8/CXCL8) protects cultured IEC against tumor necrosis factor (TNF)-alpha and cycloheximide-induced cytotoxicity.	Cycloheximide	131-144	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
15181190-2	2004	We have shown that recombinant human IL-8/CXCL8 (rhIL-8/CXCL8) protects cultured IEC against tumor necrosis factor (TNF)-alpha and cycloheximide-induced cytotoxicity.	Cycloheximide	131-144	C-X-C motif chemokine ligand 8	Homo sapiens	42-47
15181190-2	2004	We have shown that recombinant human IL-8/CXCL8 (rhIL-8/CXCL8) protects cultured IEC against tumor necrosis factor (TNF)-alpha and cycloheximide-induced cytotoxicity.	Cycloheximide	131-144	C-X-C motif chemokine ligand 8	Homo sapiens	56-61
15349669-5	2004	Analysis of the thin section by SEM after exposure to dentifrices showed that NaF/SiO(2) produced significant remineralization whereas MFP/CaCO(3) system resulted in little remineralization.	Silicon Dioxide	82-88	C-X-C motif chemokine ligand 8	Homo sapiens	78-81
15300205-10	2004	In the competing chemotactic gradient assays (C5a vs IL-8), beta-glucan further enhanced migration toward C5a while not affecting that toward IL-8.	beta-Glucans	60-71	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
15300205-11	2004	CONCLUSIONS: beta-glucan selectively upregulates PMN chemotaxis toward C5a while suppressing chemotaxis toward IL-8.	beta-Glucans	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
15143062-0	2004	Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway.	Phospholipids	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	32-45
15219825-6	2004	Eotaxin stimulated IL-8 production, which was inhibited by AG1478.	RTKI cpd	59-65	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
15242697-3	2004	Steroids modulate some plasma cytokines (decreasing TNFalpha, IL-8, IL-6 and increasing IL-10), whereas ability to reduce plasma and urinary TNFsr-2 and IL-1ra and peri-operative renal injury is unknown.	Steroids	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
15133028-2	2004	Glu-Leu-Arg ("ELR") CXC chemokines interleukin-8 (IL-8) and melanoma growth stimulatory activity (MGSA) recruit neutrophils by binding and activating two receptors, CXCR1 and CXCR2.	Glu-Leu-Arg	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	35-48
15133028-2	2004	Glu-Leu-Arg ("ELR") CXC chemokines interleukin-8 (IL-8) and melanoma growth stimulatory activity (MGSA) recruit neutrophils by binding and activating two receptors, CXCR1 and CXCR2.	Glu-Leu-Arg	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
15087294-7	2004	Dexamethasone suppressed LPS-induced granulocyte macrophage-colony stimulating factor, tumor necrosis factor-alpha, and interleukin-8 release by 83 +/- 1%, 51 +/- 7% and 20 +/- 9% (p &lt; 0.001), respectively.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	120-133
15087294-8	2004	Similar effects were seen on nuclear factor-kappaB inhibition, and interleukin-8 release was further reduced by the HDAC enhancer, theophylline (37 +/- 6%).	Theophylline	131-143	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
15143062-0	2004	Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway.	Phospholipids	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
15256456-0	2004	Expression of angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 is highly responsive to ambient glutamine availability: role of nuclear factor-kappaB and activating protein-1.	Glutamine	124-133	C-X-C motif chemokine ligand 8	Homo sapiens	72-85
15256456-0	2004	Expression of angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 is highly responsive to ambient glutamine availability: role of nuclear factor-kappaB and activating protein-1.	Glutamine	124-133	C-X-C motif chemokine ligand 8	Homo sapiens	86-91
15240713-7	2004	Stimulation of the above-mentioned cells with bacterial DNA or CpG oligodeoxynucleotide resulted in an inflammatory reaction characterized by a dose-dependent up-regulation of cytokines (IL-6, IL-8) and human beta-defensin 2.	Oligodeoxyribonucleotides	67-87	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
15240743-4	2004	RAPBTL (n = 20) induced an up-regulation of ICAM-1, intracellular IL-8, IL-6, IL-15, and surface IL-15 in cocultured RASFibs.	rapbtl	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
15256456-5	2004	VEGF and IL-8 secretion and mRNA levels were dramatically induced by glutamine deprivation.	Glutamine	69-78	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
15240743-12	2004	In turn, these cytokines stimulate the expression of IL-15, IL-8, and IL-6 in RASFibs, thereby creating a feedback loop that favors persistent synovial inflammation.	rasfibs	78-85	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
15207247-3	2004	In this report, we demonstrate, using two potent and selective inhibitors of MEK activation by Raf-1 (PD-098059) and p38 (SB-203580), that both ERK1/2 and p38 pathways play a key role in the production of IL-8 by porins and LPS.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	102-111	C-X-C motif chemokine ligand 8	Homo sapiens	205-209
15207247-3	2004	In this report, we demonstrate, using two potent and selective inhibitors of MEK activation by Raf-1 (PD-098059) and p38 (SB-203580), that both ERK1/2 and p38 pathways play a key role in the production of IL-8 by porins and LPS.	SB 203580	122-131	C-X-C motif chemokine ligand 8	Homo sapiens	205-209
15207247-4	2004	Porin-stimulated expression of activating protein 1 (AP-1) and correlated IL-8 release is also inhibited by PD-098059 or SB-203580 indicating that the Raf-1/MEK1-MEK2/MAPK cascade is required for their activation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	108-117	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
15207247-4	2004	Porin-stimulated expression of activating protein 1 (AP-1) and correlated IL-8 release is also inhibited by PD-098059 or SB-203580 indicating that the Raf-1/MEK1-MEK2/MAPK cascade is required for their activation.	SB 203580	121-130	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
15207247-5	2004	Also PTKs modulate the pathway that control IL-8 gene expression, in fact its expression is abolished by tyrphostin.	Tyrphostins	105-115	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
15223398-5	2004	RESULTS: Polyvinylchloride induced a substantial increase in IL-8 and MCP-1, which was abolished by cycloheximide, indicating that they were synthesized during incubation.	Polyvinyl Chloride	9-26	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
15111623-9	2004	Furthermore, addition of the peptide, comprising the surface loop between Cys(95) and Cys(105), predicted by model, particularly in oxidized form, decreased LPS-induced production of tumor necrosis factor alpha and interleukin-8 upon application to monocytic cells and fibroblasts, respectively, supporting its involvement in LPS signaling.	Cysteine	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	215-228
15111623-9	2004	Furthermore, addition of the peptide, comprising the surface loop between Cys(95) and Cys(105), predicted by model, particularly in oxidized form, decreased LPS-induced production of tumor necrosis factor alpha and interleukin-8 upon application to monocytic cells and fibroblasts, respectively, supporting its involvement in LPS signaling.	Cysteine	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	215-228
15223398-8	2004	Heparin-coated polyvinylchloride efficiently prevented synthesis of both IL-8 and MCP-1.	Heparin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
15223398-8	2004	Heparin-coated polyvinylchloride efficiently prevented synthesis of both IL-8 and MCP-1.	Polyvinyl Chloride	15-32	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
15223398-9	2004	Addition of recombinant human complement factor 5a to blood incubated in heparin-coated polyvinylchloride restored IL-8 and MCP-1 production completely and partly, respectively.	Heparin	73-80	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
15223398-9	2004	Addition of recombinant human complement factor 5a to blood incubated in heparin-coated polyvinylchloride restored IL-8 and MCP-1 production completely and partly, respectively.	Polyvinyl Chloride	88-105	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
15223398-13	2004	CONCLUSIONS: Polyvinylchloride induced a marked increase in IL-8 and MCP-1, in contrast to a marginal increase in tumor necrosis factor alpha, IL-1 beta, IL-6, and IL-10.	Polyvinyl Chloride	13-30	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
15223398-14	2004	The increase in IL-8 and MCP-1 was prevented by heparin-coated polyvinylchloride.	Heparin	48-55	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
15223398-14	2004	The increase in IL-8 and MCP-1 was prevented by heparin-coated polyvinylchloride.	coated polyvinylchloride	56-80	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
15196211-4	2004	In response to zymosan and flagellin, pathogen-associated molecular patterns (PAMP) that are recognized by TLR2 and TLR5 respectively, ECC-1 cells secreted significantly more IL-8, MCP-1 and IL-6 than in response to other TLR agonists.	Zymosan	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
15240502-11	2004	The inhibition of the activity of phosphoinositide-3 kinase (PI3K) with wortmannin showed that 72%-80% of the rate of pseudopod extension induced with N-formyl-methionyl-leucyl-phenylalanine, platelet activating factor, and leukotriene B4 was phosphoinositide-3 kinase-dependent, in contrast to 55% of the rate of pseudopod extension induced with interleukin-8.	Wortmannin	72-82	C-X-C motif chemokine ligand 8	Homo sapiens	347-360
15293603-4	2004	Inhibition of proteasome activity by ALLN and beta-lactone resulted in significantly increased IL-8 secretion (5- to 22-fold).	beta-Lactone	46-58	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
15384255-0	2004	Bleomycin induces IL-8 and ICAM-1 expression in microvascular pulmonary endothelial cells.	Bleomycin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
15384255-5	2004	Finally, pre-treatment with a selective p38 MAPK-inhibitor, SB 203580, potently reduced the BLM-induced up-regulation of IL-8 expression but did not show any effect on expression of ICAM-1.	SB 203580	60-69	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
15316216-11	2004	Stimulation with CS resulted in upregulation of mRNA for IL-6 and IL-8 and protein release.	Cesium	17-19	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
15190028-7	2004	RESULTS: Lag phase S. pneumoniae treated at sub-MIC (1/8 MIC) cefotaxime or faropenem induced 11-fold and 8-fold increases, respectively, in TLR2-mediated IL-8 promoter activity when compared with untreated bacteria.	Cefotaxime	62-72	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
15190028-7	2004	RESULTS: Lag phase S. pneumoniae treated at sub-MIC (1/8 MIC) cefotaxime or faropenem induced 11-fold and 8-fold increases, respectively, in TLR2-mediated IL-8 promoter activity when compared with untreated bacteria.	fropenem	76-85	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
15178710-0	2004	Nitric oxide post-transcriptionally up-regulates LPS-induced IL-8 expression through p38 MAPK activation.	Nitric Oxide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
15178710-8	2004	In THP-1 cells and human primary monocytes treated with actinomycin D, NO(.-) had no effect on TNF-alpha mRNA stability (P&gt;0.3 for both cell types) but significantly stabilized IL-8 mRNA (P=0.001 for both cell types).	Dactinomycin	56-69	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
15178710-10	2004	Further, SB202190, a p38 MAPK inhibitor, was shown to block NO(.-)-induced stabilization of IL-8 mRNA (P&lt;0.02 for both cell types).	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
15178710-12	2004	IL-8 mRNA stabilization by NO(.-) is independent of cGMP and at least partially dependent on p38 MAPK activation.	Cyclic GMP	52-56	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15028780-6	2004	Furthermore, the CXCR2-specific antagonist SB225002 [N-(2-hydroxy-4-nitrophenyl)-N"-(2-bromophenyl)urea] is 10-fold more potent in inhibiting IL-8 binding to hCXCR2 than to cCXCR2, suggesting that some of the observed differences in the amino acid sequences of the human and monkey receptor affect ligand binding sites or the conformation of the receptor.	SB 225002	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
15028780-6	2004	Furthermore, the CXCR2-specific antagonist SB225002 [N-(2-hydroxy-4-nitrophenyl)-N"-(2-bromophenyl)urea] is 10-fold more potent in inhibiting IL-8 binding to hCXCR2 than to cCXCR2, suggesting that some of the observed differences in the amino acid sequences of the human and monkey receptor affect ligand binding sites or the conformation of the receptor.	SB 225002	53-103	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
15121876-11	2004	Exposure to mifepristone made the spatial difference in IL-8 disappear and increased the expression of TNFalpha in the epithelium of the isthmus, but had no effect on the expression of TGFbeta1 or LIF.	Mifepristone	12-24	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
15162381-9	2004	Quantitative assay of BPH tissue extracts revealed that tissue IL-8 levels are correlated with both SA-beta gal activity and prostate weight.	2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid	100-111	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
15201697-14	2004	The ratios of IL-6 to IL-10 and IL-8 to IL-10 were significantly lower in DZX groups than in controls (P = 0.025 and P = 0.041 for each, respectively).	Diazoxide	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
15137059-8	2004	Cytochalasin D also activated p38 MAP kinase, which pathway contributed to the cytochalasin D-induced increase in IL-8 production.	Cytochalasin D	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
15137059-8	2004	Cytochalasin D also activated p38 MAP kinase, which pathway contributed to the cytochalasin D-induced increase in IL-8 production.	Cytochalasin D	79-93	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
15075332-4	2004	Likewise, treatment of cells with NaF (an inhibitor of protein phosphatases) allowed for phosphorylation of Ser-985, and a protein phosphatase responsible for dephosphorylation of Ser-985 was identified to be protein phosphatase 2A (PP2A).	Serine	108-111	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
15213840-7	2004	The EGFR kinase inhibitor tyrphostin AG1478 abrogated the TF/FVIIa-complex induced MAP kinase activation and mRNA increase of egr-1, heparin-binding EGF, and interleukin-8 following FVIIa addition.	Tyrphostins	26-36	C-X-C motif chemokine ligand 8	Homo sapiens	158-171
15213840-7	2004	The EGFR kinase inhibitor tyrphostin AG1478 abrogated the TF/FVIIa-complex induced MAP kinase activation and mRNA increase of egr-1, heparin-binding EGF, and interleukin-8 following FVIIa addition.	RTKI cpd	37-43	C-X-C motif chemokine ligand 8	Homo sapiens	158-171
15269990-9	2004	CONCLUSION: During cardiac surgery (mitral valve replacement) PGE1 may suppressed the production of IL-6, IL-8 but not IL-10, which may be related to its myocardial protection effect.	Alprostadil	62-66	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
15075332-4	2004	Likewise, treatment of cells with NaF (an inhibitor of protein phosphatases) allowed for phosphorylation of Ser-985, and a protein phosphatase responsible for dephosphorylation of Ser-985 was identified to be protein phosphatase 2A (PP2A).	Serine	180-183	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
15155343-9	2004	TCV-309 significantly inhibited the production of TNF, IL-6, and IL-8 induced by LPS, SEB, and bacteria.	TCV 309	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
15187156-4	2004	The adenosine analog 5"-N-ethylcarboxamidoadenosine (NECA) (10 microM) increased mRNA expression of IL-1beta, IL-3, IL-4, IL-8, and IL-13, but not IL-2 and IFN-gamma.	Adenosine	4-13	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
15187156-4	2004	The adenosine analog 5"-N-ethylcarboxamidoadenosine (NECA) (10 microM) increased mRNA expression of IL-1beta, IL-3, IL-4, IL-8, and IL-13, but not IL-2 and IFN-gamma.	Adenosine-5'-(N-ethylcarboxamide)	21-51	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
15187156-4	2004	The adenosine analog 5"-N-ethylcarboxamidoadenosine (NECA) (10 microM) increased mRNA expression of IL-1beta, IL-3, IL-4, IL-8, and IL-13, but not IL-2 and IFN-gamma.	Adenosine-5'-(N-ethylcarboxamide)	53-57	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
15188490-3	2004	HHcy unleashes mediators of inflammation such as NFkappaB, IL-1beta, IL-6, and IL-8, increases production of intracellular superoxide anion causing oxidative stress and reducing intracellular level of nitric oxide (NO), and induces endoplasmic reticulum (ER) stress which can explain many processes of Hcy-promoted cell injury such as apoptosis, fat accumulation, and inflammation.	Homocysteine	1-4	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
15147461-0	2004	Interleukin-8 and RANTES levels in patients with relapsing-remitting multiple sclerosis (RR-MS) treated with cladribine.	Cladribine	109-119	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
15147461-5	2004	RESULTS: After Cladribine treatment the levels of IL-8 decreased significantly in CSF only, whereas the RANTES levels decreased significantly both in CSF and serum.	Cladribine	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
15136298-3	2004	We therefore studied the effect of a new thiol antioxidant compound, Nacystelyn (NAL), on IL-8 regulation in a human macrophage-derived cell line (THP-1).	N-acetylcysteine lysinate	69-79	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
15136298-3	2004	We therefore studied the effect of a new thiol antioxidant compound, Nacystelyn (NAL), on IL-8 regulation in a human macrophage-derived cell line (THP-1).	N-acetylcysteine lysinate	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
15155187-1	2004	We previously showed that moxifloxacin (MXF) exerts protective anti-inflammatory effects in immunosuppressed mice infected with Candida albicans by inhibiting interleukin-8 (IL-8) and tumor necrosis factor alpha (TNF-alpha) production in the lung.	Moxifloxacin	26-38	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
15155187-1	2004	We previously showed that moxifloxacin (MXF) exerts protective anti-inflammatory effects in immunosuppressed mice infected with Candida albicans by inhibiting interleukin-8 (IL-8) and tumor necrosis factor alpha (TNF-alpha) production in the lung.	Moxifloxacin	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
15155187-3	2004	In the present study we investigated the effects of MXF on the production of proinflammatory cytokines (i.e., IL-8, TNF-alpha, and IL-1beta) by activated human peripheral blood monocytes and THP-1 cells and analyzed the effects of the drug on the major signal transduction pathways associated with inflammation: NF-kappaB and the mitogen-activated protein kinases ERK and c-Jun N-terminal kinase (JNK).	Moxifloxacin	52-55	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
15166955-5	2004	RESULTS: Gene array analysis from LCM-dissected tissues demonstrated: (i) increased expression of interleukin-8 (IL-8), an activator of the inflammatory factor nuclear factor-kappaB (NF-kappaB), and (ii) decreased expression of IkappaB (an inhibitor of NF-kappaB) in CP ductal cells compared with normal ducts.	ikappab	228-235	C-X-C motif chemokine ligand 8	Homo sapiens	98-111
15166955-5	2004	RESULTS: Gene array analysis from LCM-dissected tissues demonstrated: (i) increased expression of interleukin-8 (IL-8), an activator of the inflammatory factor nuclear factor-kappaB (NF-kappaB), and (ii) decreased expression of IkappaB (an inhibitor of NF-kappaB) in CP ductal cells compared with normal ducts.	ikappab	228-235	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
15196286-13	2004	Levocetirizine significantly reduced eosinophils (P=0.029), neutrophils (P=0.005), IL-4 (P=0.041), and IL-8 (P=0.02), whereas desloratadine diminished IL-4 only (P=0.044).	levocetirizine	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
15136050-0	2004	Aspirin inhibits monocyte chemoattractant protein-1 and interleukin-8 expression in TNF-alpha stimulated human umbilical vein endothelial cells.	Aspirin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
15136050-6	2004	In this study, we found that aspirin inhibited TNF-alpha (10 ng/ml)-induced MCP-1 and IL-8 expression at the RNA and protein levels in human umbilical vein endothelial cells (HUVECs), monocyte adhesion and transmigration, and that its inhibitory effects were not due to decreased HUVEC viability as assessed by MTT test.	Aspirin	29-36	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
15136050-7	2004	Aspirin at the dose as low as 10 microg/ml significantly inhibited the release of TNF-stimulated MCP-1 by 29.1% (P = 0.008) and IL-8 by 26.9% (P = 0.0146) as compared to TNF-stimulated release.	Aspirin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
15136050-11	2004	These results in our study suggest that aspirin inhibits TNF-alpha stimulated MCP-1 and IL-8 release in HUVECs, for its additional therapeutic effects of aspirin in causing atherosclerosis.	Aspirin	40-47	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
15235923-14	2004	Monocytes or neutrophils exposed to urate crystals produce tumor necrosis factor alpha, interleukin-1 (IL-1), IL-6, and IL-8.	Uric Acid	36-41	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
15218990-3	2004	IL-8 production was dependent on phosphorylation of ERK-1 and -2 and p38 MAPK, as examined by PD 098059 (10 microM), an inhibitor of the upstream activator of MAPK kinase (MKK)-1, and SB 203580 (10 microM), an inhibitor of p38 MAPK.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	94-103	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15329007-6	2004	Cetirizine treatment induced a significant decrease of IL4 (p&lt;0.01) and IL8 levels (p=0.01).	Cetirizine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
14717657-0	2004	Methotrexate induces interleukin-8 production by human bronchial and alveolar epithelial cells.	Methotrexate	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	21-34
14717657-5	2004	To elucidate the proinflammatory mechanism of MTX-induced pneumonitis, we evaluated the effect of MTX on the production of IL (interleukin)-8 by human bronchial and alveolar epithelial cells in vitro and the role of p38 MAPK (mitogen-activated protein kinase) in order to clarify the intracellular signal regulating IL-8 expression.	Methotrexate	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	123-141
14717657-5	2004	To elucidate the proinflammatory mechanism of MTX-induced pneumonitis, we evaluated the effect of MTX on the production of IL (interleukin)-8 by human bronchial and alveolar epithelial cells in vitro and the role of p38 MAPK (mitogen-activated protein kinase) in order to clarify the intracellular signal regulating IL-8 expression.	Methotrexate	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	123-141
14717657-6	2004	MTX induced IL-8 secretion by human bronchial and alveolar epithelial cells in a dose- and time-dependent manner within the range of the clinically observed serum concentrations.	Methotrexate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
14717657-8	2004	SB203580, the specific inhibitor of p38 MAPK, inhibited MTX-induced IL-8 production.	SB 203580	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
14717657-8	2004	SB203580, the specific inhibitor of p38 MAPK, inhibited MTX-induced IL-8 production.	Methotrexate	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
14717657-10	2004	These results suggest that MTX activates bronchial and alveolar epithelial cells to induce IL-8 production through p38 MAPK, which might play an important role as one of the mechanisms of MTX-induced lung inflammation.	Methotrexate	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
14717657-10	2004	These results suggest that MTX activates bronchial and alveolar epithelial cells to induce IL-8 production through p38 MAPK, which might play an important role as one of the mechanisms of MTX-induced lung inflammation.	Methotrexate	188-191	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
15218990-3	2004	IL-8 production was dependent on phosphorylation of ERK-1 and -2 and p38 MAPK, as examined by PD 098059 (10 microM), an inhibitor of the upstream activator of MAPK kinase (MKK)-1, and SB 203580 (10 microM), an inhibitor of p38 MAPK.	SB 203580	184-193	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15218990-6	2004	Lipopolysaccharide-induced IL-8 production was dependent on activation of NF-kappaB, as examined by SN 50 (100 microM), an inhibitor of NF-kappaB translocation, and the specific NF-kappaB inhibitor kinase-2 inhibitor, AS 602868 (10 microM), with no differences in AMs from smokers and nonsmokers.	sn 50	100-105	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
15147563-2	2004	Here we show that triggering of the formyl peptide receptor (FPR) with f-Met-Leu-Phe (fMLF) substantially reduced the neutrophil superoxide production induced by activation of the CXC receptors with IL-8.	Superoxides	129-139	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
15020655-1	2004	We previously reported that disaccharides (DS), generated by enzymatic degradation of heparin or heparan sulfate, inhibit T cell-mediated immune reactions in rodents and regulate cytokine [tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-8, and IL-1beta] secretion by T cells, macrophages, or intestinal epithelial cells.	Disaccharides	28-41	C-X-C motif chemokine ligand 8	Homo sapiens	230-248
15123733-3	2004	Previously, we have shown that short exposure of primary cutaneous melanoma cells to dacarbazine resulted in the upregulation of interleukin-8 (IL-8) and vascular endothelial growth factor (VEGF).	Dacarbazine	85-96	C-X-C motif chemokine ligand 8	Homo sapiens	129-142
15123733-3	2004	Previously, we have shown that short exposure of primary cutaneous melanoma cells to dacarbazine resulted in the upregulation of interleukin-8 (IL-8) and vascular endothelial growth factor (VEGF).	Dacarbazine	85-96	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
15123733-12	2004	We propose that combination treatment with anti-VEGF/IL-8 or MEK inhibitors may potentiate the therapeutic effects of dacarbazine.	Dacarbazine	118-129	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
14982951-7	2004	IL-1 receptor antagonist and to a lesser extent anti-TNF-alpha inhibited COBTB-induced CXCL8 secretion (P&lt;0.01) but did not affect gene expression.	cobtb	73-78	C-X-C motif chemokine ligand 8	Homo sapiens	87-92
15020655-1	2004	We previously reported that disaccharides (DS), generated by enzymatic degradation of heparin or heparan sulfate, inhibit T cell-mediated immune reactions in rodents and regulate cytokine [tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-8, and IL-1beta] secretion by T cells, macrophages, or intestinal epithelial cells.	Disaccharides	43-45	C-X-C motif chemokine ligand 8	Homo sapiens	230-248
15153529-5	2004	Incubation of human intestinal epithelial HT-29 cells with DFO increased the expression of IL-8 mRNA, as well as the release of IL-8 protein.	Deferoxamine	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
15153529-5	2004	Incubation of human intestinal epithelial HT-29 cells with DFO increased the expression of IL-8 mRNA, as well as the release of IL-8 protein.	Deferoxamine	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
15153529-7	2004	Accordingly, the selective inhibitors for both kinases, either alone or in combination, completely abolished DFO-induced IL-8 secretion, indicating an importance of mitogen-activated protein kinases pathway.	Deferoxamine	109-112	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
15153529-8	2004	These proinflammatory effects of DFO were, in large part, mediated by activation of Na(+)/H(+) exchangers, because selective blockade of Na(+)/H(+) exchangers prevented the DFO-induced IL-8 production.	Deferoxamine	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
15153529-8	2004	These proinflammatory effects of DFO were, in large part, mediated by activation of Na(+)/H(+) exchangers, because selective blockade of Na(+)/H(+) exchangers prevented the DFO-induced IL-8 production.	Deferoxamine	173-176	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
15147869-6	2004	We demonstrate that the induction of IL-8 expression by TWEAK can be counteracted by LiCl.	Lithium Chloride	85-89	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
15046772-0	2004	Monophthalates promote IL-6 and IL-8 production in the human epithelial cell line A549.	monophthalates	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
15120617-4	2004	TWEAK induced phosphorylation of IkappaBalpha and BAY11-7082, a selective inhibitor of IkappaBalpha phosphorylation, inhibited the TWEAK-induced IL-8 and GM-CSF production by BEAS2B cells.	3-(4-methylphenylsulfonyl)-2-propenenitrile	50-60	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
15135182-7	2004	In contrast to intact pyocyanin, oxidized pyocyanin was less efficient in NADH oxidation and stimulation of interleukin-8 release by human alveolar epithelial A549 cells in vitro, suggesting that oxidation of pyocyanin leads to its inactivation.	Pyocyanine	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	108-121
15135182-7	2004	In contrast to intact pyocyanin, oxidized pyocyanin was less efficient in NADH oxidation and stimulation of interleukin-8 release by human alveolar epithelial A549 cells in vitro, suggesting that oxidation of pyocyanin leads to its inactivation.	Pyocyanine	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	108-121
15120605-3	2004	The findings of this study show, for the first time, that the peroxisome proliferator-activated receptor (PPARalpha) agonist, fenofibrate, completely abolishes the LDL-induced IL-8 up-regulation at the transcriptional level.	Fenofibrate	126-137	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
15082280-5	2004	RESULTS: Interleukin-8 and tumor necrosis factor-alpha levels after cardiopulmonary bypass were significantly lower in the aminophylline group than that in the control group (P &lt; 0.05, for each group), and interleukin-10 level in aminophylline group was significantly higher than in control (P = 0.001).	Aminophylline	123-136	C-X-C motif chemokine ligand 8	Homo sapiens	9-54
15136726-0	2004	Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells.	Digitoxin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
15136726-3	2004	We show here that digitoxin, at sub nM concentrations, can suppress hypersecretion of IL-8 from cultured CF lung epithelial cells.	Digitoxin	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
15136726-11	2004	We therefore suggest that digitoxin, with its lengthy history of human use, deserves consideration as a candidate drug for suppressing IL-8-dependent lung inflammation in CF.	Digitoxin	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
15033544-10	2004	TNF-alpha and IL-1beta presented a maximum response after 1h treatment, while IL-6 and IL-8 maximum response was after 3h treatment.	Tritium	119-121	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
15033544-16	2004	These data indicate that, Cd-induced TNF-alpha and IL-1beta, that probably, activate AP-1 transcription factor and IL-6 and IL-8 were induced.	Cadmium	26-28	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
15168319-2	2004	This study was conducted to determine if treatment with the antioxidant melatonin would influence interleukin-6, interleukin-8, tumor necrosis factor alpha, and nitrite/nitrate levels in newborns with grade III or IV respiratory distress syndrome (radiographically confirmed) diagnosed within the first 6 hours of life.	Melatonin	72-81	C-X-C motif chemokine ligand 8	Homo sapiens	113-126
15168319-5	2004	Compared with the melatonin-treated respiratory distress syndrome newborns, in the untreated infants the concentrations of interleukin-6, interleukin-8, and tumor necrosis factor alpha were significantly higher at 24 hours, 72 hours, and at 7 days after onset of the study.	Melatonin	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	138-151
15097437-0	2004	Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea.	Glutamine	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	49-62
15293554-4	2004	This study examined the effects of pyrrolidine dithiocarbamate (PDTC, 0.1 mM) and spermine NONOate (Sper-NO, 1 mM) on the secretion and gene expression of chemokines, interleukin (IL)-8, monocyte chemotactic protein (MCP)-1, regulated upon activation normal T cell expressed and secreted (RANTES), and eotaxin.	spermine nitric oxide complex	82-98	C-X-C motif chemokine ligand 8	Homo sapiens	167-185
15124023-4	2004	Prevention of PBEF translation with an antisense oligonucleotide completely abrogates the inhibitory effects of LPS, IL-1, GM-CSF, IL-8, and TNF-alpha on neutrophil apoptosis.	Oligonucleotides	49-64	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
15071361-0	2004	Azelnidipine, a newly developed long-acting calcium antagonist, inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in endothelial cells through its anti-oxidative properties.	azelnidipine	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	109-122
15071361-0	2004	Azelnidipine, a newly developed long-acting calcium antagonist, inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in endothelial cells through its anti-oxidative properties.	Calcium	44-51	C-X-C motif chemokine ligand 8	Homo sapiens	109-122
15071361-3	2004	In this study, we investigated whether and how azelnidipine, a newly developed long-acting calcium antagonist, could inhibit TNF-alpha-induced IL-8 expression in human umbilical vein endothelial cells (HUVEC).	azelnidipine	47-59	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
15071361-6	2004	Further, azelnidipine was found to significantly inhibit activator protein-1 (AP-1) promoter activity and IL-8 expression in TNF-alpha-exposed HUVEC.	azelnidipine	9-21	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
15071361-7	2004	An inhibitor of AP-1, curcumin, or an anti-oxidant, N-acetylcysteine, also inhibited the TNF-alpha-induced IL-8 expression in HUVEC.	Curcumin	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
15071361-7	2004	An inhibitor of AP-1, curcumin, or an anti-oxidant, N-acetylcysteine, also inhibited the TNF-alpha-induced IL-8 expression in HUVEC.	Acetylcysteine	52-68	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
15071361-8	2004	These results demonstrated that azelnidipine inhibited TNF-alpha-induced IL-8 expression in HUVEC by blocking NADPH oxidase-mediated ROS generation and subsequent AP-1 activation.	azelnidipine	32-44	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
15071361-8	2004	These results demonstrated that azelnidipine inhibited TNF-alpha-induced IL-8 expression in HUVEC by blocking NADPH oxidase-mediated ROS generation and subsequent AP-1 activation.	Reactive Oxygen Species	133-136	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
14730005-4	2004	Consistent with its ability to inhibit PLC-beta2 enzymatic activity, U73122 reduced interleukin-8 and leukotriene B(4)-induced Ca(2+) flux and chemotaxis in human neutrophils in a concentration-dependent manner.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	69-75	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
15050605-5	2004	The p38 inhibitor SB 203580 resulted in a significant decrease in IL-8 peptide production (p &lt; 0.01).	SB 203580	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
15298427-0	2004	Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass: effects on TNF-alpha, IL-6, IL-8, IL-10.	Methylprednisolone	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
15050605-0	2004	Mechanism of glutamine-mediated amelioration of lipopolysaccharide-induced IL-8 production in Caco-2 cells.	Glutamine	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
15066049-3	2004	Previously, we found that melatonin reduced the rises in proinflammatory cytokines (IL-6, IL-8 and TNF-alpha) and nitrite/nitrate levels in the serum of preterm newborns with respiratory distress syndrome (RDS).	Melatonin	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
15298427-12	2004	CONCLUSION: In this study, we have found that preoperative administration of methylprednisolone has decreased TNF-alpha, IL-6 and IL-8 release, and increased the perfusing IL-10 levels after CPB.	Methylprednisolone	77-95	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
15050605-2	2004	We hypothesize that Gln down-regulates lipopolysaccharide (LPS)-stimulated IL-8 production in intestinal epithelial cells via transcription factors that counteract the effect of LPS-mediated increase in IL-8.	Glutamine	20-23	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
15050605-9	2004	These results indicate that Gln deprivation enhances IL-8 production by Caco-2 cells after LPS stimulation and that down-regulation of IL-8 production with Gln is associated with alterations in STAT-4 transcription factor binding.	Glutamine	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
15050605-2	2004	We hypothesize that Gln down-regulates lipopolysaccharide (LPS)-stimulated IL-8 production in intestinal epithelial cells via transcription factors that counteract the effect of LPS-mediated increase in IL-8.	Glutamine	20-23	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
15050605-9	2004	These results indicate that Gln deprivation enhances IL-8 production by Caco-2 cells after LPS stimulation and that down-regulation of IL-8 production with Gln is associated with alterations in STAT-4 transcription factor binding.	Glutamine	156-159	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
14722097-1	2004	The provision of glutamine in vivo has been observed to reduce to normal levels the neutrophilia observed after exhaustive exercise and to decrease the neutrophil chemoattractant, interleukin-8.	Glutamine	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	180-193
15081272-7	2004	We found that exposure to soluble nickel sulfate results in the induction of hypoxia-inducible genes and IL-8 production by the 1HAEo(-) cells.	nickel sulfate	34-48	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
15081272-8	2004	The simultaneous addition of iron in either ferric or ferrous form and nickel completely inhibited IL-8 production and had no effect on "hypoxia-like" stress caused by nickel, suggesting the existence of two different pathways for the induction "hypoxia-like" stress and IL-8 production.	Iron	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
15081272-8	2004	The simultaneous addition of iron in either ferric or ferrous form and nickel completely inhibited IL-8 production and had no effect on "hypoxia-like" stress caused by nickel, suggesting the existence of two different pathways for the induction "hypoxia-like" stress and IL-8 production.	Iron	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	271-275
15081272-8	2004	The simultaneous addition of iron in either ferric or ferrous form and nickel completely inhibited IL-8 production and had no effect on "hypoxia-like" stress caused by nickel, suggesting the existence of two different pathways for the induction "hypoxia-like" stress and IL-8 production.	Nickel	71-77	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
15093669-6	2004	While vanadium deficiency accounts for several physiological malfunctionings including thyroid, glucose and lipid metabolism, etc., several genes are regulated by this element or by its compounds, which include genes for tumor necrosis factor-alpha (TNF-alpha), Interleukin-8 (IL-8), activator protein-1 (AP-1), ras, c-raf-1, mitogen activated protein kinase (MAPK), p53, nuclear factors-kappaB, etc.	Vanadium	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	262-275
15093669-6	2004	While vanadium deficiency accounts for several physiological malfunctionings including thyroid, glucose and lipid metabolism, etc., several genes are regulated by this element or by its compounds, which include genes for tumor necrosis factor-alpha (TNF-alpha), Interleukin-8 (IL-8), activator protein-1 (AP-1), ras, c-raf-1, mitogen activated protein kinase (MAPK), p53, nuclear factors-kappaB, etc.	Vanadium	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	277-281
15003325-6	2004	A marked increase in the levels of nitrite (as an index of NO) and IL-8 were observed in the NO2-exposed cells, which were further enhanced in the presence of the cytokines.	Nitrogen Dioxide	93-96	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
15003325-10	2004	These results suggest a synergistic role of inflammatory mediators, particularly of NO and IL-8, in NO2-mediated early cellular changes.	Nitrogen Dioxide	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
15089887-10	2004	Lansoprazole treatment significantly reduced the IL-8 mRNA expression levels.	Lansoprazole	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
15084916-5	2004	When FLSs were co-cultured with CII-stimulated T cells, the production of interleukin-8, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1alpha was significantly enhanced.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
14656710-0	2004	Linoleic acid induces interleukin-8 production by Crohn"s human intestinal smooth muscle cells via arachidonic acid metabolites.	Linoleic Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	22-35
14656710-0	2004	Linoleic acid induces interleukin-8 production by Crohn"s human intestinal smooth muscle cells via arachidonic acid metabolites.	Arachidonic Acid	99-115	C-X-C motif chemokine ligand 8	Homo sapiens	22-35
14656710-1	2004	Previously we reported that linoleic acid (LA), but not oleic acid, caused a marked increase in the secretion of IL-8 by Crohn"s human intestinal smooth muscle (HISM) cells.	Linoleic Acid	28-41	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
14656710-1	2004	Previously we reported that linoleic acid (LA), but not oleic acid, caused a marked increase in the secretion of IL-8 by Crohn"s human intestinal smooth muscle (HISM) cells.	Oleic Acid	31-41	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
14656710-3	2004	In this study, we examined two mechanisms whereby LA, the dietary precursor for arachidonic acid (AA), could increase the production of IL-8 via activation of AA pathways: 1) by generation of reactive oxygen species by the AA-pathway enzymes to activate NF-kappaB or 2) by AA metabolites.	Arachidonic Acid	80-96	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
14656710-3	2004	In this study, we examined two mechanisms whereby LA, the dietary precursor for arachidonic acid (AA), could increase the production of IL-8 via activation of AA pathways: 1) by generation of reactive oxygen species by the AA-pathway enzymes to activate NF-kappaB or 2) by AA metabolites.	Reactive Oxygen Species	192-215	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
14656710-13	2004	Both Indo and NDGA blocked the IL-8 response to OxLA.	Indomethacin	5-9	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
14656710-13	2004	Both Indo and NDGA blocked the IL-8 response to OxLA.	oxla	48-52	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
14656710-15	2004	Similar to OxLA, OxAA stimulated production of IL-8 and AA metabolites.	oxaa	17-21	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
15025932-5	2004	These oxidized phospholipids were shown to induce several proinflammatory genes, such as monocyte chemoattractant protein 1 or interleukin-8, and it is hypothesized that lipid oxidation products also play a role in other chronic inflammatory disorders.	Phospholipids	15-28	C-X-C motif chemokine ligand 8	Homo sapiens	127-140
14656710-16	2004	Pinane thromboxane, a selective thromboxane synthase inhibitor and receptor blocker, inhibited OxAA stimulation of TXB(2) and IL-8 in a dose-response manner.	pinane thromboxane	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
14656710-17	2004	MK886, a selective 5-lipoxygenase inhibitor, inhibited OxAA stimulation of LTB(4) and IL-8 also in a dose-response manner.	MK-886	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
15026281-0	2004	Acanthoic acid inhibits IL-8 production via MAPKs and NF-kappaB in a TNF-alpha-stimulated human intestinal epithelial cell line.	acanthoic acid	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
15077296-6	2004	IL-8, MCP-1, and MIP-1 alpha levels in SF were strongly correlated with T cell responses to CII.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	92-95	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15077296-7	2004	When FLS were cocultured with CII-stimulated T cells, the production of IL-8, MCP-1, and MIP-1 alpha was significantly increased.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
15077296-10	2004	CONCLUSION: Our data indicate that the presence of CII-reactive T cells in RA joints can increase the production of chemokines such as IL-8, MCP-1, and MIP-1 alpha through interaction with FLS.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
15077296-10	2004	CONCLUSION: Our data indicate that the presence of CII-reactive T cells in RA joints can increase the production of chemokines such as IL-8, MCP-1, and MIP-1 alpha through interaction with FLS.	CHEMBL1232769	189-192	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
15452608-1	2004	In the complex with chitosan, lipopolysaccharide partially lost its ability to induce lymphokines tumor necrosis factor and interleukin-8, but retained immunostimulating properties and increased phagocytic function of macrophages by improving digestion of bacteria.	Chitosan	20-28	C-X-C motif chemokine ligand 8	Homo sapiens	124-137
15023565-0	2004	Native LDL induces interleukin-8 expression via H2O2, p38 Kinase, and activator protein-1 in human aortic smooth muscle cells.	Hydrogen Peroxide	48-52	C-X-C motif chemokine ligand 8	Homo sapiens	19-32
15023565-5	2004	METHODS AND RESULTS: LDL-induced IL-8 expression (mRNA and protein) is specific to SMCs and likely to be regulated at the transcription level in dose- and time-dependent manners, as judged by experiments with actinomycin D and ELISA.	Dactinomycin	209-222	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
15023565-6	2004	Although both p38 and ERK 1/2 MAPKs were activated by LDL, only p38 MAPK is responsible for the LDL effects, as evidenced by a complete blockade of IL-8 upregulation by SB203580.	SB 203580	169-177	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
15023565-7	2004	Pretreatment with catalase significantly decreased the extent of IL-8 upregulation, indicating that H2O2 is necessary for the LDL response.	Hydrogen Peroxide	100-104	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
15023565-9	2004	CONCLUSIONS: These data demonstrated that LDL stimulates SMCs to induce IL-8 production in dose- and time-dependent manners at the transcription level and that the LDL signaling in hAoSMCs is conveyed via the generation of H2O2, the phosphorylation of p38 MAPK, the activation of AP-1, and the participation of NF-kappaB.	Hydrogen Peroxide	223-227	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
15026281-4	2004	The aim of this study was to examine the inhibitory effect of acanthoic acid isolated from Acanthopanax koreanum (Araliaceae), on IL-8 production via mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-kappaB) in TNF-alpha-stimulated human colon epithelial cells.	acanthoic acid	62-76	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
15026281-9	2004	RESULTS: Acanthoic acid suppressed TNF-alpha-induced IL-8 production in a dose-dependent manner.	acanthoic acid	9-23	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
15026281-11	2004	CONCLUSION: Acanthoic acid might inhibit TNF-alpha-mediated IL-8 production by blocking in both the MAPKs and NF-kappaB pathways in HT29 cells.	acanthoic acid	12-26	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
15056377-2	2004	The present study demonstrates that CXCL8 induces tyrosine phosphorylation as well as enzymatic activity of proline-rich tyrosine kinase 2 (Pyk2), a non-receptor protein tyrosine kinase (PTK), in human neutrophils.	Tyrosine	50-58	C-X-C motif chemokine ligand 8	Homo sapiens	36-41
15068414-8	2004	Teprenone inhibited H. pylori-enhanced IL-8 production in MKN28 gastric epithelial cells in vitro, in a dose-dependent manner.	geranylgeranylacetone	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
15068414-9	2004	CONCLUSIONS: Teprenone may modify corpus H. pylori-associated gastritis through its effect on neutrophil infiltration and H. pylori density, in part by its inhibition of IL-8 production in the gastric mucosa.	geranylgeranylacetone	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
15056377-3	2004	Induction of Pyk2 tyrosine phosphorylation by CXCL8 is regulated by Src PTK activation, whereas it is unaffected by phosphatidylinositol 3-kinase activation.	Tyrosine	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	46-51
14999747-5	2004	No significant difference between these three fluorides was observed although a general trend was seen where KF-treated PCL appeared to degrade slower than NaF-treated PCL which was slower than NH(4)F-treated PCL.	polycaprolactone	168-171	C-X-C motif chemokine ligand 8	Homo sapiens	156-159
15379216-5	2004	Ozone exposure (3.0 ppm, 3 min) time-dependently changed the redox state, while increasing production of interleukin(IL)-8 and IL-6, mRNA and protein.	Ozone	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	105-122
15379216-6	2004	Treatment with GSH-OEt before ozone suppressed IL-8, but stimulated IL-6 production.	S-ethyl glutathione	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
15005855-0	2004	Calcium signaling pathway involving calcineurin regulates interleukin-8 gene expression through activation of NF-kappaB in human osteoblast-like cells.	Calcium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	58-71
15379213-2	2004	Intracellular levels of cytokine-induced IL-8 in human umbilical vein endothelial cells (HUVEC) were modulated using interferons and steroids to further elucidate their mechanism.	Steroids	133-141	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
15379213-7	2004	Our study indicated that both, dexamethasone and IFN inhibit TNF-alpha-induced upregulation of IL-8 at the mRNA level.	Dexamethasone	31-44	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
14999747-5	2004	No significant difference between these three fluorides was observed although a general trend was seen where KF-treated PCL appeared to degrade slower than NaF-treated PCL which was slower than NH(4)F-treated PCL.	polycaprolactone	168-171	C-X-C motif chemokine ligand 8	Homo sapiens	156-159
14999747-6	2004	Variation in solubilities of the salts was observed where the K(+) cation had the highest solubility and the Na(+) cation had the lowest solubility, which suggests that NaF was able to degrade the polymer more efficiently than the other fluorides.	Fluorides	237-246	C-X-C motif chemokine ligand 8	Homo sapiens	169-172
15031337-7	2004	Pre-incubation of the MC layer for 48 h with 55 mM glucose, a combination of two glucose degradation products, methylglyoxal and 3-deoxyglucosone, or conventional dialysis fluid (1:4 dilution), however, did not change the IL-8-induced migration of neutrophils.	Methylcholanthrene	22-24	C-X-C motif chemokine ligand 8	Homo sapiens	222-226
15115777-4	2004	We found that 2-arachidonoylglycerol induced a marked acceleration in the production of interleukin 8.	glyceryl 2-arachidonate	14-36	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
15115777-6	2004	Augmented production of interleukin 8 was also observed with CP55940, a synthetic cannabinoid, and an ether-linked analog of 2-arachidonoylglycerol.	3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol	61-68	C-X-C motif chemokine ligand 8	Homo sapiens	24-37
15115777-6	2004	Augmented production of interleukin 8 was also observed with CP55940, a synthetic cannabinoid, and an ether-linked analog of 2-arachidonoylglycerol.	Cannabinoids	82-93	C-X-C motif chemokine ligand 8	Homo sapiens	24-37
15115777-6	2004	Augmented production of interleukin 8 was also observed with CP55940, a synthetic cannabinoid, and an ether-linked analog of 2-arachidonoylglycerol.	Ether	102-107	C-X-C motif chemokine ligand 8	Homo sapiens	24-37
15115777-6	2004	Augmented production of interleukin 8 was also observed with CP55940, a synthetic cannabinoid, and an ether-linked analog of 2-arachidonoylglycerol.	glyceryl 2-arachidonate	125-147	C-X-C motif chemokine ligand 8	Homo sapiens	24-37
15115777-9	2004	The accelerated production of interleukin 8 by 2-arachidonoylglycerol was observed not only in undifferentiated HL-60 cells, but also in HL-60 cells differentiated into macrophage-like cells.	glyceryl 2-arachidonate	47-69	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
15115777-10	2004	Noticeably, 2-arachidonoylglycerol and lipopolysaccharide acted synergistically to induce the dramatically augmented production of interleukin 8.	glyceryl 2-arachidonate	12-34	C-X-C motif chemokine ligand 8	Homo sapiens	131-144
15020194-7	2004	Nickel contact induced upregulation of MMP-2 and IL-8 mRNA production.	Nickel	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
15020196-9	2004	SP administration decreased the release of interleukin (IL)-8 normally seen in keratinocytes after JP-8 exposure, a response similar to that reported for SP"s effect on JP-8 pulmonary toxicity.	JP-8	99-103	C-X-C motif chemokine ligand 8	Homo sapiens	43-61
15019093-5	2004	The inhibitory effect of L-NIL was also observed on the PM2.5-induced interleukin-8 (IL-8) gene expression both at the transcriptional and protein levels.	N(6)-(1-iminoethyl)lysine	25-30	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
15019093-5	2004	The inhibitory effect of L-NIL was also observed on the PM2.5-induced interleukin-8 (IL-8) gene expression both at the transcriptional and protein levels.	N(6)-(1-iminoethyl)lysine	25-30	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
14670967-2	2004	In the current study, we demonstrated that LPA is a potent inducer of interleukin-6 (IL-6) and interleukin-8 (IL-8) production in ovarian cancer cells.	lysophosphatidic acid	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	95-108
14670967-2	2004	In the current study, we demonstrated that LPA is a potent inducer of interleukin-6 (IL-6) and interleukin-8 (IL-8) production in ovarian cancer cells.	lysophosphatidic acid	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
14670967-8	2004	Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines.	lysophosphatidic acid	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
14670967-8	2004	Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines.	lysophosphatidic acid	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
14670967-8	2004	Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines.	lysophosphatidic acid	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
14670967-8	2004	Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines.	lysophosphatidic acid	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
14670967-8	2004	Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines.	lysophosphatidic acid	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
14670967-8	2004	Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines.	lysophosphatidic acid	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
14670967-10	2004	These studies elucidate the transcriptional mechanism and the Edg LPA receptors involved in LPA-induced IL-6 and IL-8 production and suggest potential strategies to restrain the expression of these cytokines in ovarian cancer.	lysophosphatidic acid	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
14712497-0	2004	Enhanced radiosensitization and chemosensitization in NF-kappaB-suppressed human oral cancer cells via the inhibition of gamma-irradiation- and 5-FU-induced production of IL-6 and IL-8.	Fluorouracil	144-148	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
14993105-14	2004	Diosmectite exhibited a dose-dependent capacity to adsorb proteins in vitro as well as a dose-dependent inhibitory effect on the basolateral secretion of IL-8 by lipopolysaccharide (LPS)-stimulated HT29 cells.	Smectite	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
14743348-3	2004	Agents that activate monocytes, including lipopolysacharrides (LPS), cytomegalovirus (CMV), and tumor necrosis factor (TNFalpha), have been shown to de-repress translation and these agents stabilize adhesion-induced transcripts for IL-lbeta and IL-8 and markedly diminish cell migration in the presence of autologous serum.	lipopolysacharrides	42-61	C-X-C motif chemokine ligand 8	Homo sapiens	232-249
15041999-8	2004	Pretreatment of the ovarian cancer cells with the pertussis toxin completely inhibited lysophosphatidic acid-stimulated production of interleukin-6, interleukin-8 and tumor necrosis factor-alpha.	lysophosphatidic acid	87-108	C-X-C motif chemokine ligand 8	Homo sapiens	149-194
14656946-0	2004	The bile acid deoxycholic acid (DCA) at neutral pH activates NF-kappaB and induces IL-8 expression in oesophageal cells in vitro.	Bile Acids and Salts	4-13	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
14656946-0	2004	The bile acid deoxycholic acid (DCA) at neutral pH activates NF-kappaB and induces IL-8 expression in oesophageal cells in vitro.	Deoxycholic Acid	14-30	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
14656946-0	2004	The bile acid deoxycholic acid (DCA) at neutral pH activates NF-kappaB and induces IL-8 expression in oesophageal cells in vitro.	Deoxycholic Acid	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
14656946-6	2004	We show that physiological levels of DCA (100-300 microM) were capable of activating NF-kappaB in OE33 cells and inducing NF-kappaB target gene expression (particularly IkappaB and IL-8).	Deoxycholic Acid	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
14977935-6	2004	Furthermore, an NF-kappaB inhibitor (pyrrolidine dithiocarbamate), a mitogen-activated protein (MAP) kinase (MEK) inhibitor (PD98059), and a p38 MAP kinase inhibitor (SB203580) significantly suppressed IL-8 synthesis in neutrophils.	pyrrolidine dithiocarbamic acid	37-64	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
15037215-0	2004	Penta-O-galloyl-beta-D-glucose inhibits phorbol myristate acetate-induced interleukin-8 [correction of intereukin-8] gene expression in human monocytic U937 cells through its inactivation of nuclear factor-kappaB.	penta-o-galloyl-beta-d-glucose	0-30	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
15037215-0	2004	Penta-O-galloyl-beta-D-glucose inhibits phorbol myristate acetate-induced interleukin-8 [correction of intereukin-8] gene expression in human monocytic U937 cells through its inactivation of nuclear factor-kappaB.	Tetradecanoylphorbol Acetate	40-65	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
15037212-4	2004	Cetirizine, supposed to inhibit DNA binding activity of NF-kappa B, inhibits the expression of adhesion molecules on immunocytes and endothelial cells and the production of IL-8 and LTB4, two potent chemoattractants, by immune cells.	Cetirizine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
14712497-7	2004	ELISA analysis indicated that although a remarkable increase in production of IL-6 and IL-8 was observed in B88 and B88neo after in vitro exposure to IR or treatment with 5-FU, radiotherapy and chemotherapy-induced production of these cytokines was significantly suppressed in B88mI cell clones.	Fluorouracil	171-175	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
15037215-1	2004	We investigated the effects of the gallotannin penta-O-galloyl-beta-d-glucose (PGG) on interleukin (IL)-8 gene expression and nuclear factor (NF)-kappaB activation.	gallotannin penta-o-galloyl-beta-d-glucose	35-77	C-X-C motif chemokine ligand 8	Homo sapiens	87-105
15187340-2	2004	Tacalcitol inhibited the mRNA expression and protein production of TPA-induced macrophage inflammatory protein-2 (MIP-2) and KC, the functional analogue of human interleukin (IL)-8, in the skin.	1 alpha,24-dihydroxyvitamin D3	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	162-180
15037215-1	2004	We investigated the effects of the gallotannin penta-O-galloyl-beta-d-glucose (PGG) on interleukin (IL)-8 gene expression and nuclear factor (NF)-kappaB activation.	pgg	79-82	C-X-C motif chemokine ligand 8	Homo sapiens	87-105
15037215-2	2004	PGG inhibited IL-8 production and gene expression in human monocytic U937 cells stimulated with phorbol myristate acetate (PMA), as measured by enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction analysis, respectively.	pgg	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
15037215-2	2004	PGG inhibited IL-8 production and gene expression in human monocytic U937 cells stimulated with phorbol myristate acetate (PMA), as measured by enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction analysis, respectively.	Tetradecanoylphorbol Acetate	96-121	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
15037215-2	2004	PGG inhibited IL-8 production and gene expression in human monocytic U937 cells stimulated with phorbol myristate acetate (PMA), as measured by enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction analysis, respectively.	Tetradecanoylphorbol Acetate	123-126	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
15037215-5	2004	PGG also inhibited both IL-8 production and NF-kappaB activation in the U937 cells stimulated with tumor necrosis factor-alpha.	pgg	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
15037215-6	2004	These results suggest that PGG, a major constituent of the root cortex of Paeonia suffruticosa ANDREWS, can inhibit IL-8 gene expression by a mechanism involving its inhibition of NF-kappaB activation, which is dependent on I-kappaBalpha degradation.	pgg	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
15001649-0	2004	Effects of thrombin, hypoxia, and steroids on interleukin-8 expression in decidualized human endometrial stromal cells: implications for long-term progestin-only contraceptive-induced bleeding.	Steroids	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	46-59
15016021-8	2004	the control group used a sodium fluoride (NaF)-containing dentifrice and mouthrinse.	Sodium Fluoride	25-40	C-X-C motif chemokine ligand 8	Homo sapiens	42-45
15128054-10	2004	In 82 RAU patients with the serum IL-6 or IL-8 levels higher than the upper limit of normal serum concentration, treatment with levamisole for a period of 0.5-3.5 months could significantly reduce the serum IL-6 level from 12.0 +/- 1.6 to 3.0 +/- 0.5 pg/ml (P &lt; 0.001), and could significantly lower the serum IL-8 level from 70.9 +/- 11.2 to 13.8 +/- 3.1 pg/ml (P &lt; 0.001).	Levamisole	128-138	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
15334993-9	2004	Addition of NaF or SnF2 resulted in higher fluoride release than the control group (p &lt; 0.05).	Fluorides	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
15334993-12	2004	Addition of NaF or SnF2 in an alginate impression material may result in effective release of fluoride without deteriorating the properties of material itself.	Alginates	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
15334993-12	2004	Addition of NaF or SnF2 in an alginate impression material may result in effective release of fluoride without deteriorating the properties of material itself.	Fluorides	94-102	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
15128054-10	2004	In 82 RAU patients with the serum IL-6 or IL-8 levels higher than the upper limit of normal serum concentration, treatment with levamisole for a period of 0.5-3.5 months could significantly reduce the serum IL-6 level from 12.0 +/- 1.6 to 3.0 +/- 0.5 pg/ml (P &lt; 0.001), and could significantly lower the serum IL-8 level from 70.9 +/- 11.2 to 13.8 +/- 3.1 pg/ml (P &lt; 0.001).	Levamisole	128-138	C-X-C motif chemokine ligand 8	Homo sapiens	313-317
15128054-12	2004	Levamisole can modulate both the serum IL-6 and IL-8 levels in RAU patients.	Levamisole	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
15128054-13	2004	IL-8, like IL-6, is also a useful serum marker in evaluating therapeutic effects of levamisole on RAU patients.	Levamisole	84-94	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15026548-5	2004	Bortezomib also inhibited secretion of the proangiogenic factors matrix metalloproteinase-9, interleukin-8 (IL-8), and vascular endothelial growth factor (VEGF).	Bortezomib	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	93-106
15034288-0	2004	[Deoxycholic acid-induced signal transduction in HT-29 cells: role of NF-kappa B and interleukin-8].	Deoxycholic Acid	1-17	C-X-C motif chemokine ligand 8	Homo sapiens	85-98
15034288-5	2004	Time and concentration courses of DCA-induced secretion of IL-8 were measured with ELISA in supernatants of cultured media from the cells.	Deoxycholic Acid	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
15034288-7	2004	Moreover, DCA-induced secretions of IL-8 were measured after pretreatment with TUDC.	Deoxycholic Acid	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
15034288-7	2004	Moreover, DCA-induced secretions of IL-8 were measured after pretreatment with TUDC.	ursodoxicoltaurine	79-83	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
15034288-9	2004	The secretions of IL-8 were increased with DCA (50-200 micro M) treatment in a time and dose-dependent manner.	Deoxycholic Acid	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
15034288-10	2004	Pre-incubation of the cells with TUDC (0.1-10 micro M) for 2 hours caused significant decreases in DCA induced IL-8 secretion.	ursodoxicoltaurine	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
15034288-10	2004	Pre-incubation of the cells with TUDC (0.1-10 micro M) for 2 hours caused significant decreases in DCA induced IL-8 secretion.	Deoxycholic Acid	99-102	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
15034288-12	2004	CONCLUSIONS: DCA may play as a colonic tumor promoter through anti-apoptotic effect of NF-kappa B activation and IL-8 expression, and DCA-induced NF-kappa B independent IL-8 expression is inhibited by TUDC.	Deoxycholic Acid	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
15034288-12	2004	CONCLUSIONS: DCA may play as a colonic tumor promoter through anti-apoptotic effect of NF-kappa B activation and IL-8 expression, and DCA-induced NF-kappa B independent IL-8 expression is inhibited by TUDC.	Deoxycholic Acid	134-137	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
15026559-0	2004	Correspondence re: DC Lev et al., Dacarbazine causes transcriptional up-regulation of interleukin 8 and vascular endothelial growth factor in melanoma cells: a possible escape mechanism from chemotherapy.	Dacarbazine	34-45	C-X-C motif chemokine ligand 8	Homo sapiens	86-99
15026548-5	2004	Bortezomib also inhibited secretion of the proangiogenic factors matrix metalloproteinase-9, interleukin-8 (IL-8), and vascular endothelial growth factor (VEGF).	Bortezomib	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
15065641-5	2004	When plasmids encoding human IL8-glucagon 19-29 chimeric protein were injected into rats to evaluate the accuracy of this method, there was a high correlation between chimeric proteins measured by an enzyme-linked immunosorbent assay for human IL8 and one by a radioimmunoassay for glucagon.	Glucagon	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
14982601-6	2004	Stretch-induced IL-8 and IL-6 production were significantly inhibited when intracellular GSH was further increased by NAC or GSH-e (P &lt; 0.0001).	Glutathione	89-92	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
14982601-6	2004	Stretch-induced IL-8 and IL-6 production were significantly inhibited when intracellular GSH was further increased by NAC or GSH-e (P &lt; 0.0001).	Acetylcysteine	118-121	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
14982601-6	2004	Stretch-induced IL-8 and IL-6 production were significantly inhibited when intracellular GSH was further increased by NAC or GSH-e (P &lt; 0.0001).	gsh-e	125-130	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
14982601-7	2004	Stretch-induced IL-8 and IL-6 production were augmented when intracellular GSH was depleted by BSO (P &lt; 0.0001).	Glutathione	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
14982601-8	2004	NAC blocked stretch-induced NF-kappa B and AP-1 binding and inhibited IL-8 mRNA expression.	Acetylcysteine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
15162835-4	2004	Madimadi dose-dependently inhibited TNF-alpha, IL-1beta, and IL-8 production from activated human mast cells (HMC-1).	madimadi	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
14984736-0	2004	Differential role for phospholipase D1 and phospholipase D2 in 12-O-tetradecanoyl-13-phorbol acetate-stimulated MAPK activation, Cox-2 and IL-8 expression.	12-o-tetradecanoyl-13-phorbol acetate	63-100	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
15028114-0	2004	Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000.	6,7-diphenyl-2,3-dihydro-1H-pyrrolizine	92-103	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
14768058-6	2004	PTX-B inhibited also interleukin-8 secretion and virus expression stimulated in chronically infected U1 promonocytic cells by intra- and/or extracellular Tat.	pumiliotoxin B	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	21-34
14698135-13	2004	In the every 3-week paclitaxel group, increase in IL-8 level correlated positively with flu-like symptom (p=0.008).	Paclitaxel	20-30	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
14769732-9	2004	Improvements in induced-sputum interleukin-8 (p = 0.03) and FEV(1) (p = 0.04) were observed at day 14 and day 30, respectively, in the group receiving tgAAVCF when compared to those receiving placebo.	tgaavcf	151-158	C-X-C motif chemokine ligand 8	Homo sapiens	31-44
12738686-0	2004	Low molecular weight hyaluronan from stretched lung enhances interleukin-8 expression.	Hyaluronic Acid	21-31	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
14634065-3	2004	Although these are detectable even without stimulation, immunoglobulin (Ig)E receptor cross-linking is able to enhance only TNF-alpha production, but phorbol 12-myristate 13-acetate additionally promotes IL-1beta and IL-8.	Tetradecanoylphorbol Acetate	150-181	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
14966737-4	2004	The aim of this study has been to determine if melatonin would lower interleukin (IL)-6, IL-8, tumor necrosis factor alpha (TNF-alpha) and nitrite/nitrate (NOx) levels and modify serum inflammation parameters, improving the clinical course of surgical neonates.	Melatonin	47-56	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
14966737-12	2004	In group 1a the immediate postoperative values of cytokines were significantly higher than group 1b and group 2, but a significant improvement was observed after administration of melatonin with significantly lower levels of IL-6 and IL-8 with respect to group 2.	Melatonin	180-189	C-X-C motif chemokine ligand 8	Homo sapiens	234-238
14693163-4	2004	Glucan induced the highest level of IL-1beta mRNA and protein release after 3 h. IL-8 was induced at 3 h after glucan, but not after LPS, induction, which indicates different induction pathways.	Glucans	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
14693163-4	2004	Glucan induced the highest level of IL-1beta mRNA and protein release after 3 h. IL-8 was induced at 3 h after glucan, but not after LPS, induction, which indicates different induction pathways.	Glucans	111-117	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
12909591-0	2004	Differential roles for NF-kappa B in endotoxin and oxygen induction of interleukin-8 in the macrophage.	Oxygen	51-57	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
15203565-2	2004	In this study, our experiments were designed to determine the role of the transcription factor nuclear factor-kappaB (NF-kappaB) and intracellular calcium in the production of interleukin (IL)-8, a main chemotactic factor, by human-derived monocytic cell line U937 and by a human epithelial HEp-2 cell line infected with M. bovis BCG.	Calcium	147-154	C-X-C motif chemokine ligand 8	Homo sapiens	176-194
15203565-7	2004	When calcium influx was suppressed in M. bovis-infected cell lines, IL-8 secretion was inhibited.	Calcium	5-12	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
15203565-8	2004	Notably, specific inhibitors of NF-kappaB (sulfasalazine and curcumin) inhibited M. bovis-induced IL-8 secretion from U937 cells or HEp-2 cells.	Sulfasalazine	43-56	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
15203565-8	2004	Notably, specific inhibitors of NF-kappaB (sulfasalazine and curcumin) inhibited M. bovis-induced IL-8 secretion from U937 cells or HEp-2 cells.	Curcumin	61-69	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
15203565-10	2004	Furthermore, the results showed that calcium influx had a direct effect on IL-8 secretion in U937 cells or HEp-2 cells infected with M. bovis.	Calcium	37-44	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
14663153-7	2004	With HFOV, IL-8 gene expression was highly reduced in alveolar macrophages: 10 +/- 3.4 copies IL-8 mRNA/copy HPRT mRNA versus 356 +/- 142; p &lt; 0.05 (bronchiolar epithelial cells: 33 +/- 16 versus 208 +/- 108; alveolar septum: 2.1 +/- 1.3 versus 26 +/- 11; bronchiolar smooth muscle cells: 1.3 +/- 0.3 versus 2.8 +/- 1.0; vascular smooth muscle cells: 0.7 +/- 0.3 versus 1.1 +/- 0.4).	hfov	5-9	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
14663153-7	2004	With HFOV, IL-8 gene expression was highly reduced in alveolar macrophages: 10 +/- 3.4 copies IL-8 mRNA/copy HPRT mRNA versus 356 +/- 142; p &lt; 0.05 (bronchiolar epithelial cells: 33 +/- 16 versus 208 +/- 108; alveolar septum: 2.1 +/- 1.3 versus 26 +/- 11; bronchiolar smooth muscle cells: 1.3 +/- 0.3 versus 2.8 +/- 1.0; vascular smooth muscle cells: 0.7 +/- 0.3 versus 1.1 +/- 0.4).	hfov	5-9	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
14738568-8	2004	RESULTS: We found that glutamine deprivation and treatment with a chemical inducer of ER stress (tunicamycin) caused a marked induction of the secretion of both VEGF and IL-8 protein by a human breast adenocarcinoma cell line (TSE cells).	Glutamine	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
14738568-8	2004	RESULTS: We found that glutamine deprivation and treatment with a chemical inducer of ER stress (tunicamycin) caused a marked induction of the secretion of both VEGF and IL-8 protein by a human breast adenocarcinoma cell line (TSE cells).	Tunicamycin	97-108	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
14738568-9	2004	Glutamine deprivation, glucose deprivation and several chemical inducers of ER stress increased VEGF and IL-8 mRNA expression in TSE and other breast cancer cell lines cultured under both normoxic and hypoxic conditions, though hypoxia generally diminished the effects of glucose deprivation.	Glutamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
14738568-10	2004	Of all amino acids tested, ambient glutamine availability had the largest effect on VEGF and IL-8 mRNA expression.	Glutamine	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
14527339-2	2004	By immunoprecipitation using an anti-syndecan-2 antibody on TNF-alpha-stimulated HUVEC lysates, inflammation-induced interleukin-8 was found to be an interaction partner of this HS (heparan sulphate) proteoglycan, but not of any other syndecan on these cells.	Heparitin Sulfate	182-198	C-X-C motif chemokine ligand 8	Homo sapiens	117-130
14705951-5	2004	Naloxone induced peripheral blood nonadherent mononuclear cell and neutrophil chemotaxis at nanomolar concentrations and deactivated their migration toward beta-endorphin, angiotensin II, somatostatin, or interleukin-8 but not toward RANTES, vasoactive intestinal peptide, or substance P.	Naloxone	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	205-218
12948934-4	2004	In response to hrHRF, these cells induced IL-8 mRNA expression within 4 h. H2O2, but not IL-1 beta or tumor necrosis factor-alpha, stimulated secretion of HRF p23 by BEAS-2B cells, suggesting that oxidative stress may trigger the release of HRF p23 from bronchial epithelial cells.	Hydrogen Peroxide	75-79	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
13129857-6	2004	Dexamethasone (50 nM) attenuated IL-8 production by 50% (P &lt; 0.05), and IL-1beta (2 microg/l) increased IL-8 production up to 15-fold (P &lt; 0.001).	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
15630185-0	2004	Regulation of interleukin-8 secretion in human intestinal epithelial Caco-2 cells by alpha-humulene.	humulene	85-99	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
14706599-9	2004	RESULTS: Heparin concentrations &gt; or =20 IU/mL significantly increased LPS-induced IL-8 production.	Heparin	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
15630234-8	2004	The H2O2 induced increase in IL-8 secretion was inhibited by a pretreatment with carnosine for 3 h, this inhibition being presented in a dose-dependent manner.	Hydrogen Peroxide	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
15630185-4	2004	Among the compounds known to be contained in peppermint and dokudami, alpha-humulene substantially increased the IL-8 secretion.alpha-Humulene had no significant effect on the secretion of such other soluble factors as TNF-alpha, IL-1beta, IL-6, or NGF, suggesting that the effect of alpha-humulene was specific for IL-8 secretion.	humulene	70-84	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
15630185-5	2004	The expression level of IL-8 mRNA was significantly increased by treating with alpha-humulene.	humulene	79-93	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
15630185-6	2004	These results suggest that the secretion of IL-8 by alpha-humulene is regulated at the transcriptional level.	humulene	52-66	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
15273781-0	2004	Effect of 0.02% NaF solution on enamel demineralization and fluoride uptake by deciduous teeth in vitro.	Fluorides	60-68	C-X-C motif chemokine ligand 8	Homo sapiens	16-19
15273781-3	2004	The treatment with fluoride dentifrice was more effective in reducing enamel demineralization (p &lt; 0.05) and on fluoride uptake by the enamel (p &lt; 0.05) than the non-fluoride dentifrice and the 0.02% NaF solution.	Fluorides	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	206-209
14718443-13	2004	G-CSF in serum and IL-8 in BALF correlated negatively with PaO(2)/fraction of inspired oxygen (FIO(2)) ratio.	Oxygen	87-93	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
14684972-5	2004	Two hours after brushing with fluoride toothpaste containing AmF and NaF, the salivary fluoride levels were still higher than baseline levels.	Fluorides	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
14684972-5	2004	Two hours after brushing with fluoride toothpaste containing AmF and NaF, the salivary fluoride levels were still higher than baseline levels.	Fluorides	87-95	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
15005008-0	2004	Effects of physiological concentrations of steroid hormones and interleukin-11 on basal and stimulated production of interleukin-8 by human osteoblast-like cells with different functional profiles.	Steroids	43-59	C-X-C motif chemokine ligand 8	Homo sapiens	117-130
15005008-7	2004	RESULTS: Cortisol dose-dependently inhibited spontaneous IL-8 secretion in both cell lines, although statistical significance was attained in the MG-63 cells only (P &lt; 0.01); no effect of 17 beta-estradiol was apparent.	Hydrocortisone	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
15005008-4	2004	The aim of the present study was to evaluate the single and combined effects of physiological concentrations of cortisol, 17 beta-estradiol and IL-11 upon basal and IL-1 beta-inducible production of IL-8 in two human osteoblast-like cell lines, Saos-2 and MG-63.	Hydrocortisone	112-120	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
15005008-8	2004	With regard to IL-1 beta-inducible production, cortisol dose-dependently inhibited IL-8 release in both cell lines (P &lt; 0.01); 17 beta-estradiol resulted in only a non-significant decrease in Saos-2, but not in MG-63 cells.	Hydrocortisone	47-55	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
15005008-4	2004	The aim of the present study was to evaluate the single and combined effects of physiological concentrations of cortisol, 17 beta-estradiol and IL-11 upon basal and IL-1 beta-inducible production of IL-8 in two human osteoblast-like cell lines, Saos-2 and MG-63.	Estradiol	122-139	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
14967603-6	2004	Both IL-8 and RANTES were significantly released by 48 hours following inoculation with RSV.	Respiratory Syncytial Virus Vaccines	88-91	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
14741067-0	2004	Effect of interleukin 8 and ICAM-1 on calcium-dependent outflow of K+ in erythrocytes from subjects with essential hypertension.	Calcium	38-45	C-X-C motif chemokine ligand 8	Homo sapiens	10-23
14740733-4	2004	During reaction of metaschoepite in NaNO3, CsNO3, and NaF solutions, an initial increase in the dissolved uranium concentration was followed by a decrease as uranium was incorporated into a secondary solid phase.	Uranium	106-113	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
14740733-4	2004	During reaction of metaschoepite in NaNO3, CsNO3, and NaF solutions, an initial increase in the dissolved uranium concentration was followed by a decrease as uranium was incorporated into a secondary solid phase.	Uranium	158-165	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
14967603-9	2004	The authors conclude that, in differentiated human airway epithelium in vitro, RSV-induced increases in IL-8 and RANTES release are predominantly in the basolateral direction.	Respiratory Syncytial Virus Vaccines	79-82	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
14734137-0	2004	N-acetylcysteine inhibits interleukin-17-induced interleukin-8 production from human airway smooth muscle cells: a possible role for anti-oxidative treatment in chronic lung rejection?	Acetylcysteine	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	49-62
15568616-8	2004	This additive effect on IL-8 release was reduced when the cells were also treated with PD-098059, a selective inhibitor of the MEK1 activator and the MAPK cascade, or SB203580, a specific inhibitor of the p38 pathway, or AG490, a specific JAK/STAT pathway inhibitor, providing evidence that there are different signal pathways activated which have a cumulative effect.	SB 203580	167-175	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
15349826-7	2004	On the basis of the consensus sequence glutamic acid-leucine-arginine (ELR) preceding the canonical cysteine-any amino acid-cysteine (CXC), ELR-positive CXC chemokines, such as interleukin-8 and granulocyte chemotactic protein-2, are angiogenic and thus instruct the host to feed the tumor and bring the vessels into closer contact with the tumor cells.	elr	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	177-190
15349826-7	2004	On the basis of the consensus sequence glutamic acid-leucine-arginine (ELR) preceding the canonical cysteine-any amino acid-cysteine (CXC), ELR-positive CXC chemokines, such as interleukin-8 and granulocyte chemotactic protein-2, are angiogenic and thus instruct the host to feed the tumor and bring the vessels into closer contact with the tumor cells.	amino acid-cysteine	113-132	C-X-C motif chemokine ligand 8	Homo sapiens	177-190
14730209-11	2004	The specific tyrosine kinase inhibitor, genistein, and the protein kinase C (PKC) inhibitor, Ro 31-8220, also inhibited IL-8 release and mRNA expression as well as p38 and NF-kappaB activation.	Genistein	40-49	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
14734137-9	2004	CONCLUSIONS: We demonstrated that human airway smooth muscle cells, when stimulated with IL-17, are able to produce 8-isoprostane, which could be inhibited by adding N-acetylcysteline, and which was also able to decrease IL-17-induced IL-8 production.	8-epi-prostaglandin F2alpha	116-129	C-X-C motif chemokine ligand 8	Homo sapiens	235-239
14734137-9	2004	CONCLUSIONS: We demonstrated that human airway smooth muscle cells, when stimulated with IL-17, are able to produce 8-isoprostane, which could be inhibited by adding N-acetylcysteline, and which was also able to decrease IL-17-induced IL-8 production.	n-acetylcysteline	166-183	C-X-C motif chemokine ligand 8	Homo sapiens	235-239
14661260-2	2004	It was found that the fracture of titanium occurred in neutral 2.0% NaF solution as well as in 2.0% acidulated phosphate fluoride (APF) solution.	Titanium	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
15509017-9	2004	We report here on the potency of nano-metal particles with single or binary chemical components in eliciting interleukin-8 (IL-8) production from epithelial cell lines.	Metals	38-43	C-X-C motif chemokine ligand 8	Homo sapiens	109-122
15509017-9	2004	We report here on the potency of nano-metal particles with single or binary chemical components in eliciting interleukin-8 (IL-8) production from epithelial cell lines.	Metals	38-43	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
15509017-10	2004	For single-component nanoparticles, we found that nano-Cu particles were more potent in IL-8 production than nano-Ni and nano-V particles.	Copper	55-57	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
15509017-12	2004	When sulfuric acid was introduced to form acidified nano-Ni particles, we found that the potency of such binary-component nanoparticles in eliciting IL-8 production was increased markedly, by about six times.	sulfuric acid	5-18	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
15509017-14	2004	Since Ni, a transition metal, could induce free radicals on cell surfaces, while Na and Mg could not, the acidity might have enhanced the oxidative stress caused by radicals to the cells, leading to markedly higher IL-8 production.	Free Radicals	43-56	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
14734137-8	2004	N-acetylcysteine (NAC) was able to decrease IL-17-induced 8-isoprostane production, with a maximum decrease of 59.3 +/- 9% (p &lt; 0.001, n = 12) with 10 mmol/liter of N-acetylcysteine, which also decreased IL-17-induced IL-8 production in a concentration-dependent manner (with maximum inhibition of 86.3% when combined with NAC 10 mmol/liter as compared with IL-17 alone).	Acetylcysteine	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	221-225
14734137-8	2004	N-acetylcysteine (NAC) was able to decrease IL-17-induced 8-isoprostane production, with a maximum decrease of 59.3 +/- 9% (p &lt; 0.001, n = 12) with 10 mmol/liter of N-acetylcysteine, which also decreased IL-17-induced IL-8 production in a concentration-dependent manner (with maximum inhibition of 86.3% when combined with NAC 10 mmol/liter as compared with IL-17 alone).	Acetylcysteine	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	221-225
14756775-7	2004	In addition, recombinant N-pmpD activated human monocytes in vitro by upregulating their metabolic activity and by stimulating IL-8 release in a dose-dependent manner.	n-pmpd	25-31	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
14688319-6	2004	Furthermore, NK cells respond to poly(I:C) by producing proinflammatory cytokines like IL-6 and IL-8, as well as the antiviral cytokine IFN-gamma.	poly	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
14688319-6	2004	Furthermore, NK cells respond to poly(I:C) by producing proinflammatory cytokines like IL-6 and IL-8, as well as the antiviral cytokine IFN-gamma.	Iodine	38-39	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
14688319-6	2004	Furthermore, NK cells respond to poly(I:C) by producing proinflammatory cytokines like IL-6 and IL-8, as well as the antiviral cytokine IFN-gamma.	Carbon	40-41	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
15082095-3	2004	This should result in passive attachment (stem cells to tagged tissue or organ); and (3) Reticulose, which stimulates the synthesis of the stem cell chemoattractant IL-8, could be magnetically guided to target tissue(s) and/or organ(s).	reticulose	89-99	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
15046557-5	2004	Conversely, TNF-alpha, IL-6, and IL-8 increased reactive oxygen species production and the expression of CD11b and CD15 on both neutrophils and monocytes and decreased the expression of CD62L.	Reactive Oxygen Species	48-71	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
15165037-6	2004	The presence of NaF in the assay mixture resulted to a decreased degradation of alkylacetylphosphatidic acid, as well as to an increased overall product formation.	alkylacetylphosphatidic acid	80-108	C-X-C motif chemokine ligand 8	Homo sapiens	16-19
14979662-5	2004	PDGF-AB, TGF-beta1 and IL-8 provoke conformational changes in mollusk immunocytes, involving the signaling transduction pathways of phosphatidylinositol and cAMP.	Phosphatidylinositols	132-152	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
14979662-5	2004	PDGF-AB, TGF-beta1 and IL-8 provoke conformational changes in mollusk immunocytes, involving the signaling transduction pathways of phosphatidylinositol and cAMP.	Cyclic AMP	157-161	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
15230146-8	2004	Furthermore TNF-alpha and IL-8 levels correlated with pleocytosis, and protein and glucose levels, whereas IL-1 beta correlated with pleocytosis and protein level in CSF.	Glucose	83-90	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
14643170-5	2004	Pre-treatment with beclomethasone, budesonide or fluticasone reduced TNFalpha- and IL-1beta-stimulated IL-8 and RANTES release from HASMC in a dose dependent manner.	Beclomethasone	19-33	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
14643170-5	2004	Pre-treatment with beclomethasone, budesonide or fluticasone reduced TNFalpha- and IL-1beta-stimulated IL-8 and RANTES release from HASMC in a dose dependent manner.	Budesonide	35-45	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
14643170-5	2004	Pre-treatment with beclomethasone, budesonide or fluticasone reduced TNFalpha- and IL-1beta-stimulated IL-8 and RANTES release from HASMC in a dose dependent manner.	Fluticasone	49-60	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
14643170-7	2004	TNFalpha- and IL-1beta-induced RANTES and IL-8 expression was reduced on the transcriptional level by pre-treatment with fluticasone and budesonide.	Fluticasone	121-132	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
14643170-7	2004	TNFalpha- and IL-1beta-induced RANTES and IL-8 expression was reduced on the transcriptional level by pre-treatment with fluticasone and budesonide.	Budesonide	137-147	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
14643170-8	2004	The results suggest that the topical steroids fluticasone, budesonide and to a lesser extent beclomethasone may have beneficial effects on airway inflammation in asthma by reducing RANTES and IL-8-induced leukocyte infiltration into the airway wall.	Steroids	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
14643170-2	2004	This study was performed to investigate the effectiveness of the commonly used steroids beclomethasone, budesonide and fluticasone in downregulating HASMC production of RANTES and IL-8.	Steroids	79-87	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
14643170-2	2004	This study was performed to investigate the effectiveness of the commonly used steroids beclomethasone, budesonide and fluticasone in downregulating HASMC production of RANTES and IL-8.	Beclomethasone	88-102	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
14643170-2	2004	This study was performed to investigate the effectiveness of the commonly used steroids beclomethasone, budesonide and fluticasone in downregulating HASMC production of RANTES and IL-8.	Budesonide	104-114	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
14643170-2	2004	This study was performed to investigate the effectiveness of the commonly used steroids beclomethasone, budesonide and fluticasone in downregulating HASMC production of RANTES and IL-8.	Fluticasone	119-130	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
14643170-2	2004	This study was performed to investigate the effectiveness of the commonly used steroids beclomethasone, budesonide and fluticasone in downregulating HASMC production of RANTES and IL-8.	hasmc	149-154	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
14643170-8	2004	The results suggest that the topical steroids fluticasone, budesonide and to a lesser extent beclomethasone may have beneficial effects on airway inflammation in asthma by reducing RANTES and IL-8-induced leukocyte infiltration into the airway wall.	Fluticasone	46-57	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
14643170-8	2004	The results suggest that the topical steroids fluticasone, budesonide and to a lesser extent beclomethasone may have beneficial effects on airway inflammation in asthma by reducing RANTES and IL-8-induced leukocyte infiltration into the airway wall.	Budesonide	59-69	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
14643170-8	2004	The results suggest that the topical steroids fluticasone, budesonide and to a lesser extent beclomethasone may have beneficial effects on airway inflammation in asthma by reducing RANTES and IL-8-induced leukocyte infiltration into the airway wall.	Beclomethasone	93-107	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
20021137-12	2004	Replacement of NaCl with LiCl decreased the L-cysteine uptake by about 5-fold and in the presence of NaF decrease in L-cysteine uptake was about 2 fold.	Sodium Chloride	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
16295318-9	2004	The results demonstrate an important oxidative aggression induced by three sources: the alcohol metabolism in the hepatocytes, activated Kupffer cells and activated neutrophils that have infiltrated the liver, due to the chemoattractant effect of IL-8.	Alcohols	88-95	C-X-C motif chemokine ligand 8	Homo sapiens	247-251
15081568-0	2004	The effect of TNF-alpha, PMA, and LPS on plasma and cell-associated IL-8 in human leukocytes.	Tetradecanoylphorbol Acetate	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
15108454-7	2004	A negative correlation was discovered between IL-1 beta, TNF alpha and body mass index; IL-8 and osteocalcine.	osteocalcine	97-109	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
20021137-12	2004	Replacement of NaCl with LiCl decreased the L-cysteine uptake by about 5-fold and in the presence of NaF decrease in L-cysteine uptake was about 2 fold.	Cysteine	117-127	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
15606218-8	2004	The combination of corticosteroids and LABA potentiates inhibition of interleukin-8 and eotaxin release from human airway smooth muscle cells and granulocyte-macrophage colony-stimulating factor release from epithelial cells, and also the inhibition of airway smooth muscle cell proliferation.	LABA	39-43	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
14719805-0	2003	Semisynthesis and application of carboxyfluorescein-labelled biologically active human interleukin-8.	6-carboxyfluorescein	33-51	C-X-C motif chemokine ligand 8	Homo sapiens	87-100
14615068-6	2003	As results, retinoid-induced inflammation was mainly mediated through MCP-1 and IL-8 as evidenced by increased levels of mRNA expression and protein secretion.	Retinoids	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
14615068-10	2003	In conclusion, the present study demonstrated that among proinflammatory cytokines, MCP-1 and IL-8 mainly mediated retinol-induced skin irritation, and that inhibition of production of these cytokines can be applied as good markers to screen the anti-irritants against the retinol-induced irritation.	Vitamin A	115-122	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
14615068-10	2003	In conclusion, the present study demonstrated that among proinflammatory cytokines, MCP-1 and IL-8 mainly mediated retinol-induced skin irritation, and that inhibition of production of these cytokines can be applied as good markers to screen the anti-irritants against the retinol-induced irritation.	Vitamin A	273-280	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
16465705-5	2003	The diffusion coefficients of cobalt(II) tris(bipyridine), ferrocenemethyltrimethylammonium ion, and dicyanobis(phenanthroline)iron(II) and their rate of change as the gel dried were found to be nearly identical for gels prepared from TMOS and catalyzed with either HCl, NH3, or NaF.	cobalt(ii) tris	30-45	C-X-C motif chemokine ligand 8	Homo sapiens	279-282
14719805-4	2003	The ligation site was chosen with respect to the position of four cysteine residues within the hIL-8 sequence.	Cysteine	66-74	C-X-C motif chemokine ligand 8	Homo sapiens	95-100
14719805-5	2003	Ligation with synthetic peptides that carry cysteine at their N-termini resulted in full-length hIL-8 and the specifically carboxyfluorescein-labelled analogue [K69(CF)]hIL-8(1-77).	Cysteine	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	96-101
14719805-5	2003	Ligation with synthetic peptides that carry cysteine at their N-termini resulted in full-length hIL-8 and the specifically carboxyfluorescein-labelled analogue [K69(CF)]hIL-8(1-77).	Cysteine	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	169-174
14719805-5	2003	Ligation with synthetic peptides that carry cysteine at their N-termini resulted in full-length hIL-8 and the specifically carboxyfluorescein-labelled analogue [K69(CF)]hIL-8(1-77).	6-carboxyfluorescein	123-141	C-X-C motif chemokine ligand 8	Homo sapiens	169-174
14719805-6	2003	[K69(CF)]hIL-8(1-77) was fully active as shown by inhibition of cAMP production.	Cyclic AMP	64-68	C-X-C motif chemokine ligand 8	Homo sapiens	9-14
14636727-11	2003	The extent of STT was correlated best to IL-8 (r=0.75), IL-6 (r=0.54), and creatine kinase (CK, r=0.49) plasma concentrations.	SCHEMBL22553698	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
14613754-0	2003	Linoleic acid, but not oleic acid, upregulates the production of interleukin-8 by human intestinal smooth muscle cells isolated from patients with Crohn"s disease.	Linoleic Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
14613754-0	2003	Linoleic acid, but not oleic acid, upregulates the production of interleukin-8 by human intestinal smooth muscle cells isolated from patients with Crohn"s disease.	Oleic Acid	3-13	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
14613754-2	2003	In this study, we investigated the hypothesis that dietary fatty acids, linoleic acid (LA) and oleic acid (OA), could be involved in the inflammatory response through stimulation of the neutrophil chemokine, IL-8.	dietary fatty acids	51-70	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
14613754-2	2003	In this study, we investigated the hypothesis that dietary fatty acids, linoleic acid (LA) and oleic acid (OA), could be involved in the inflammatory response through stimulation of the neutrophil chemokine, IL-8.	Linoleic Acid	72-85	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
14613754-2	2003	In this study, we investigated the hypothesis that dietary fatty acids, linoleic acid (LA) and oleic acid (OA), could be involved in the inflammatory response through stimulation of the neutrophil chemokine, IL-8.	Oleic Acid	75-85	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
14613754-2	2003	In this study, we investigated the hypothesis that dietary fatty acids, linoleic acid (LA) and oleic acid (OA), could be involved in the inflammatory response through stimulation of the neutrophil chemokine, IL-8.	Oleic Acid	107-109	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
14636828-3	2003	Treatment of neutrophils with MCD caused inhibition of intracellular calcium increase evoked by interleukin-8 (IL-8) or low concentrations of formyl-Met-Leu-Phe (fMLP).	methyl-beta-cyclodextrin	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	96-109
14575864-3	2003	Stimulation of IL-8 expression was completely attenuated by two inhibitors of mitogen-activated protein kinase (MAPK) kinase (MEK), which phosphorylates the MAPKs extracellular-regulated kinase (ERK)1 and ERK2, and by the c-Jun NH2-terminal kinase (JNK) inhibitor SP600125.	pyrazolanthrone	264-272	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
12876073-8	2003	AT mRNA of TNF-alpha, IL-6, and IL-8 was increased in AT of HALS subjects (P &lt; 0.05), and both AT TNF-alpha mRNA and plasma TNF-alpha were negatively correlated to plasma adiponectin (P &lt; 0.05).	Fluoxymesterone	60-64	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
14676436-0	2003	Exposure to toluene diisocyanate (TDI) induces IL-8 production from bronchial epithelial cells: effect of pro-inflammatory cytokines.	Toluene 2,4-Diisocyanate	12-32	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
14676436-0	2003	Exposure to toluene diisocyanate (TDI) induces IL-8 production from bronchial epithelial cells: effect of pro-inflammatory cytokines.	Toluene 2,4-Diisocyanate	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
14676436-1	2003	This investigation was designed to confirm IL-8 production from human bronchial epithelial cells with toluene diisocyanate (TDI) exposure and to examine the effects of pro-inflammatory cytokine and dexamethasone.	Toluene 2,4-Diisocyanate	102-122	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
14676436-1	2003	This investigation was designed to confirm IL-8 production from human bronchial epithelial cells with toluene diisocyanate (TDI) exposure and to examine the effects of pro-inflammatory cytokine and dexamethasone.	Toluene 2,4-Diisocyanate	124-127	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
14676436-6	2003	There was a significant production of IL-8 from bronchial epithelial cells with addition of TDI-HSA conjugate in a dose-dependent manner, which was significantly augmented with addition of PBMC supernatant.	tdi-hsa	92-99	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
14676436-9	2003	Pre-treatment of dexamethasone induced dose-dependent inhibition of the IL-8 production.	Dexamethasone	17-30	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
14725359-1	2003	PURPOSE: The aim of the study was to investigate the effect of histidine on the stability and physical properties of a fully human anti-IL8 monoclonal antibody (ABX-IL8) in aqueous and solid forms.	Histidine	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
14725359-1	2003	PURPOSE: The aim of the study was to investigate the effect of histidine on the stability and physical properties of a fully human anti-IL8 monoclonal antibody (ABX-IL8) in aqueous and solid forms.	Histidine	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	165-168
14725359-1	2003	PURPOSE: The aim of the study was to investigate the effect of histidine on the stability and physical properties of a fully human anti-IL8 monoclonal antibody (ABX-IL8) in aqueous and solid forms.	CHEMBL369125	161-164	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
14725359-1	2003	PURPOSE: The aim of the study was to investigate the effect of histidine on the stability and physical properties of a fully human anti-IL8 monoclonal antibody (ABX-IL8) in aqueous and solid forms.	CHEMBL369125	161-164	C-X-C motif chemokine ligand 8	Homo sapiens	165-168
14725359-11	2003	CONCLUSIONS: Histidine enhanced the stability of ABX-IL8 in both aqueous and lyophilized forms.	Histidine	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
14615040-2	2003	We have previously shown that Fas ligation induces expression of chemokines such as interleukin-8 by human astrogliomas, which may partially explain the in vivo angiogenic property of FasL.	ammonium ferrous sulfate	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
12812920-5	2003	However, zinc deficiency increased the levels of TNF-alpha, IL-1 beta, and IL-8 cytokines and mRNAs in HL-60 cells after 6 h of PMA stimulation compared with zinc-sufficient cells.	Tetradecanoylphorbol Acetate	128-131	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
12876073-0	2003	Increased expression of TNF-alpha, IL-6, and IL-8 in HALS: implications for reduced adiponectin expression and plasma levels.	Fluoxymesterone	53-57	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
14636828-3	2003	Treatment of neutrophils with MCD caused inhibition of intracellular calcium increase evoked by interleukin-8 (IL-8) or low concentrations of formyl-Met-Leu-Phe (fMLP).	methyl-beta-cyclodextrin	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
14636828-3	2003	Treatment of neutrophils with MCD caused inhibition of intracellular calcium increase evoked by interleukin-8 (IL-8) or low concentrations of formyl-Met-Leu-Phe (fMLP).	Calcium	69-76	C-X-C motif chemokine ligand 8	Homo sapiens	96-109
14636828-3	2003	Treatment of neutrophils with MCD caused inhibition of intracellular calcium increase evoked by interleukin-8 (IL-8) or low concentrations of formyl-Met-Leu-Phe (fMLP).	Calcium	69-76	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
14636828-8	2003	Cholesterol depletion greatly inhibited IL-8-induced elastase release but had little effect of fMLP-induced degranulation.	Cholesterol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
14676436-10	2003	These results suggest that the IL-8 production from bronchial epithelial cells contribute to neutrophil recruitment occurring in TDI-induced airway inflammation.	Toluene 2,4-Diisocyanate	129-132	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
14599546-3	2003	5-FU increased interleukin-8 production and induced morphological signs of irritation.	Fluorouracil	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
12842821-5	2003	However, iron/ascorbate-mediated lipid peroxidation promoted inhibitor-kappaB degradation and NF-kappaB activation, as well as gave rise to IL-8, cyclooxygenase-2, and ICAM-1.	Iron	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
12842821-5	2003	However, iron/ascorbate-mediated lipid peroxidation promoted inhibitor-kappaB degradation and NF-kappaB activation, as well as gave rise to IL-8, cyclooxygenase-2, and ICAM-1.	Ascorbic Acid	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
14499342-5	2003	Lipopolysaccharide (LPS)-induced IL-8 production was inhibited by SB203580, but not by the MK2 inhibitory peptide.	SB 203580	66-74	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
12958044-4	2003	We thus investigated whether synthesis of IL-8 from primary human aortic smooth muscle cells is influenced by CsA and FK506.	Tacrolimus	118-123	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
14981920-1	2003	We have recently found that sodium fluoride (NaF) induced apoptotic cell death in tumor cell lines.	Sodium Fluoride	28-43	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
14981920-7	2003	NaF reduced the glucose consumption at early stage, possibly by inhibition of glycolysis, whereas cisplatin and etoposide reduced the glucose consumption at later stage, suggesting that early decline of glucose consumption is rather specific to NaF.	Glucose	16-23	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
14981920-7	2003	NaF reduced the glucose consumption at early stage, possibly by inhibition of glycolysis, whereas cisplatin and etoposide reduced the glucose consumption at later stage, suggesting that early decline of glucose consumption is rather specific to NaF.	Cisplatin	98-107	C-X-C motif chemokine ligand 8	Homo sapiens	245-248
14981920-7	2003	NaF reduced the glucose consumption at early stage, possibly by inhibition of glycolysis, whereas cisplatin and etoposide reduced the glucose consumption at later stage, suggesting that early decline of glucose consumption is rather specific to NaF.	Etoposide	112-121	C-X-C motif chemokine ligand 8	Homo sapiens	245-248
12908082-0	2003	Induction of TNF-alpha, uPA, IL-8 and MCP-1 by doxorubicin in human lung carcinoma cells.	Doxorubicin	47-58	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
12908082-1	2003	PURPOSE: We have previously demonstrated doxorubicin-induced urokinase (uPA) and interleukin-8 (IL-8) expression in human H69 small-cell lung carcinoma (SCLC) cells by a microarray technique using Human Cancer Chip version 2, in which 425 human "cancer-related" genes are spotted on the plates.	Doxorubicin	41-52	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
12908082-1	2003	PURPOSE: We have previously demonstrated doxorubicin-induced urokinase (uPA) and interleukin-8 (IL-8) expression in human H69 small-cell lung carcinoma (SCLC) cells by a microarray technique using Human Cancer Chip version 2, in which 425 human "cancer-related" genes are spotted on the plates.	Doxorubicin	41-52	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
14605526-12	2003	Interleukin-8 decreased significantly only in those who received N-acetylcysteine (p =.0081).	Acetylcysteine	65-81	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
14625697-6	2003	When preincubated with enzyme, several chelators such as citrate, NaF, N-(2-hydroxyethyl) ethylenediaminetriacetic acid or ethylenediaminetriacetic acid efficiently protected the enzyme against the aluminum inactivation.	Aluminum	198-206	C-X-C motif chemokine ligand 8	Homo sapiens	66-69
14625697-7	2003	In a related experiment, only citrate and NaF released the aluminum from the completely inactivated aluminum-enzyme complex and fully recovered the enzyme activity.	Aluminum	59-67	C-X-C motif chemokine ligand 8	Homo sapiens	42-45
14642127-6	2003	RESULTS: After 96 hours exposure to arsenic trioxide, 10 - 6 mol/L in vitro or 10 mg/d in vivo, APL cells showed a significant increase of IL-1(beta) (P &lt; 0.05) and G-CSF (P &lt; 0.05) production, and a significant decrease of IL-6 (P &lt; 0.05) and IL-8 (P &lt; 0.05).	Arsenic Trioxide	36-52	C-X-C motif chemokine ligand 8	Homo sapiens	253-257
14605526-14	2003	CONCLUSIONS: Administration of N-acetylcysteine results in decreased nuclear factor-kappa B activation in patients with sepsis, associated with decreases in interleukin-8 but not interleukin-6 or soluble intercellular adhesion molecule-1.	Acetylcysteine	31-47	C-X-C motif chemokine ligand 8	Homo sapiens	157-170
14572605-0	2003	Selenium-containing compounds attenuate peroxynitrite-mediated NF-kappaB and AP-1 activation and interleukin-8 gene and protein expression in human leukocytes.	Selenium	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	97-110
14572605-1	2003	A growing body of evidence indicates that the powerful oxidant peroxynitrite (ONOO(-)) may function as an intracellular signal for production of proinflammatory cytokines, such as interleukin-8 (IL-8) in human leukocytes.	Peroxynitrous Acid	63-76	C-X-C motif chemokine ligand 8	Homo sapiens	180-193
14572605-1	2003	A growing body of evidence indicates that the powerful oxidant peroxynitrite (ONOO(-)) may function as an intracellular signal for production of proinflammatory cytokines, such as interleukin-8 (IL-8) in human leukocytes.	Peroxynitrous Acid	63-76	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
14572605-1	2003	A growing body of evidence indicates that the powerful oxidant peroxynitrite (ONOO(-)) may function as an intracellular signal for production of proinflammatory cytokines, such as interleukin-8 (IL-8) in human leukocytes.	onoo(-)	78-85	C-X-C motif chemokine ligand 8	Homo sapiens	180-193
14572605-1	2003	A growing body of evidence indicates that the powerful oxidant peroxynitrite (ONOO(-)) may function as an intracellular signal for production of proinflammatory cytokines, such as interleukin-8 (IL-8) in human leukocytes.	onoo(-)	78-85	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
14572605-2	2003	In this study, we investigated whether selenomethionine, selenocysteine, and the synthetic organoselenium compound ebselen (2-phenyl-1,2-benzisoselenazol-3(2h)-one) could inhibit ONOO(-)-mediated IL-8 gene expression in human leukocytes in whole blood.	ebselen	124-163	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
14572605-3	2003	At micromolar concentrations, ebselen, selenomethionine, and selenocysteine effectively prevented nuclear accumulation of activator protein-1 (AP-1) and nuclear factor kappaB (NF-kappaB) evoked by exogenous ONOO(-), in both polymorphonuclear and mononuclear leukocytes, and inhibited IL-8 gene and protein expression.	ebselen	30-37	C-X-C motif chemokine ligand 8	Homo sapiens	284-288
14572605-3	2003	At micromolar concentrations, ebselen, selenomethionine, and selenocysteine effectively prevented nuclear accumulation of activator protein-1 (AP-1) and nuclear factor kappaB (NF-kappaB) evoked by exogenous ONOO(-), in both polymorphonuclear and mononuclear leukocytes, and inhibited IL-8 gene and protein expression.	Selenomethionine	39-55	C-X-C motif chemokine ligand 8	Homo sapiens	284-288
14572605-3	2003	At micromolar concentrations, ebselen, selenomethionine, and selenocysteine effectively prevented nuclear accumulation of activator protein-1 (AP-1) and nuclear factor kappaB (NF-kappaB) evoked by exogenous ONOO(-), in both polymorphonuclear and mononuclear leukocytes, and inhibited IL-8 gene and protein expression.	Selenocysteine	61-75	C-X-C motif chemokine ligand 8	Homo sapiens	284-288
14671485-10	2003	In vitro studies revealed that UR-12715 or 5-ASA (from 10(-6) to 10(-4) M) inhibited IL-8 production (30-40%) in HT-29 cells when incubated with LPS.	Urea	31-33	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
14572605-5	2003	Furthermore, ebselen, selenomethionine, and selenocysteine markedly reduced LPS-evoked intracellular ONOO(-) formation in leukocytes, resulting in 36-66% decreases in nuclear accumulation of AP-1 and NF-kappaB in both polymorphonuclear and mononuclear leukocytes and inhibition of IL-8 mRNA expression and IL-8 release.	ebselen	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	281-285
14671485-10	2003	In vitro studies revealed that UR-12715 or 5-ASA (from 10(-6) to 10(-4) M) inhibited IL-8 production (30-40%) in HT-29 cells when incubated with LPS.	5-Aminosalicylic acid	43-48	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
14572605-5	2003	Furthermore, ebselen, selenomethionine, and selenocysteine markedly reduced LPS-evoked intracellular ONOO(-) formation in leukocytes, resulting in 36-66% decreases in nuclear accumulation of AP-1 and NF-kappaB in both polymorphonuclear and mononuclear leukocytes and inhibition of IL-8 mRNA expression and IL-8 release.	ebselen	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	306-310
14572605-5	2003	Furthermore, ebselen, selenomethionine, and selenocysteine markedly reduced LPS-evoked intracellular ONOO(-) formation in leukocytes, resulting in 36-66% decreases in nuclear accumulation of AP-1 and NF-kappaB in both polymorphonuclear and mononuclear leukocytes and inhibition of IL-8 mRNA expression and IL-8 release.	Selenomethionine	22-38	C-X-C motif chemokine ligand 8	Homo sapiens	281-285
14572605-5	2003	Furthermore, ebselen, selenomethionine, and selenocysteine markedly reduced LPS-evoked intracellular ONOO(-) formation in leukocytes, resulting in 36-66% decreases in nuclear accumulation of AP-1 and NF-kappaB in both polymorphonuclear and mononuclear leukocytes and inhibition of IL-8 mRNA expression and IL-8 release.	Selenomethionine	22-38	C-X-C motif chemokine ligand 8	Homo sapiens	306-310
14572605-5	2003	Furthermore, ebselen, selenomethionine, and selenocysteine markedly reduced LPS-evoked intracellular ONOO(-) formation in leukocytes, resulting in 36-66% decreases in nuclear accumulation of AP-1 and NF-kappaB in both polymorphonuclear and mononuclear leukocytes and inhibition of IL-8 mRNA expression and IL-8 release.	Selenocysteine	44-58	C-X-C motif chemokine ligand 8	Homo sapiens	281-285
14572605-5	2003	Furthermore, ebselen, selenomethionine, and selenocysteine markedly reduced LPS-evoked intracellular ONOO(-) formation in leukocytes, resulting in 36-66% decreases in nuclear accumulation of AP-1 and NF-kappaB in both polymorphonuclear and mononuclear leukocytes and inhibition of IL-8 mRNA expression and IL-8 release.	Selenocysteine	44-58	C-X-C motif chemokine ligand 8	Homo sapiens	306-310
14666025-3	2003	This study was designed to compare the effects of epsilon-aminocaproic acid and aprotinin on plasma levels of interleukin-6 and interleukin-8 during and after cardiopulmonary bypass.	Aminocaproic Acid	50-75	C-X-C motif chemokine ligand 8	Homo sapiens	128-141
12960242-0	2003	Nicotine induces human neutrophils to produce IL-8 through the generation of peroxynitrite and subsequent activation of NF-kappaB.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
12960242-0	2003	Nicotine induces human neutrophils to produce IL-8 through the generation of peroxynitrite and subsequent activation of NF-kappaB.	Peroxynitrous Acid	77-90	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
14596794-1	2003	The role of lysophosphatidylcholine (LPC) in the induction of MCP-1, IL-8 and RANTES, which are chemotactic factors to monocytes, neutrophils and lymphocytes, respectively, by human vascular endothelial cells (EC), was examined.	Lysophosphatidylcholines	12-35	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
14596794-1	2003	The role of lysophosphatidylcholine (LPC) in the induction of MCP-1, IL-8 and RANTES, which are chemotactic factors to monocytes, neutrophils and lymphocytes, respectively, by human vascular endothelial cells (EC), was examined.	Lysophosphatidylcholines	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
14596794-2	2003	LPC induced the expression of MCP-1 and IL-8 in a concentration- and time-dependent manner in microvascular EC (MVEC) and in large vessel EC from aorta, pulmonary artery and umbilical vein.	Lysophosphatidylcholines	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
14596794-9	2003	An inhibitor of the MAPK/ERK pathway, PD98059, blocked the phosphorylation of ERK1/2 and RANTES induction by LPC, but augmented IL-8 induction.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	38-45	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
14596794-11	2003	Inhibition of p38 MAP kinase pathway by SB202190 also blocked LPC-induced expression of IL-8 and RANTES.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	40-48	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
12975484-3	2003	The putative Ins(1,4,5)P3 receptor antagonist 2-aminoethoxydiphenyl borane reduced the response to CXCR2 activation by interleukin-8, as did sustained inhibition of phosphatidylinositol 4-kinase with wortmannin, suggesting the involvement of phosphoinositides in the potentiation.	2-aminoethoxydiphenylborane	46-74	C-X-C motif chemokine ligand 8	Homo sapiens	119-132
12975484-3	2003	The putative Ins(1,4,5)P3 receptor antagonist 2-aminoethoxydiphenyl borane reduced the response to CXCR2 activation by interleukin-8, as did sustained inhibition of phosphatidylinositol 4-kinase with wortmannin, suggesting the involvement of phosphoinositides in the potentiation.	Wortmannin	200-210	C-X-C motif chemokine ligand 8	Homo sapiens	119-132
12975484-3	2003	The putative Ins(1,4,5)P3 receptor antagonist 2-aminoethoxydiphenyl borane reduced the response to CXCR2 activation by interleukin-8, as did sustained inhibition of phosphatidylinositol 4-kinase with wortmannin, suggesting the involvement of phosphoinositides in the potentiation.	Phosphatidylinositols	242-259	C-X-C motif chemokine ligand 8	Homo sapiens	119-132
14646384-0	2003	Azelastine inhibits secretion of IL-6, TNF-alpha and IL-8 as well as NF-kappaB activation and intracellular calcium ion levels in normal human mast cells.	azelastine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
14646384-3	2003	METHODS: We investigated the effect of azelastine on the secretion of IL-6, TNF-alpha and IL-8 from hCBMC, as well as its possible mechanism of action.	azelastine	39-49	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
14646384-9	2003	CONCLUSION: Azelastine inhibited hCBMC secretion of IL-6, TNF-alpha and IL-8, possibly by inhibiting intracellular Ca2+ ions and NF-kappaB activation.	azelastine	12-22	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
12960242-3	2003	Nicotine stimulated neutrophils to produce IL-8 in both time- and concentration-dependent manners with a 50% effective concentration of 1.89 mM.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
12960242-6	2003	The NOS inhibitor, nomega-Nitro-l-arginine methyl ester, prevented nicotine-induced IL-8 production, with an entire abrogation of DHR oxidation, IkappaB degradation, and NF-kappaB activity.	NG-Nitroarginine Methyl Ester	19-55	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
12960242-6	2003	The NOS inhibitor, nomega-Nitro-l-arginine methyl ester, prevented nicotine-induced IL-8 production, with an entire abrogation of DHR oxidation, IkappaB degradation, and NF-kappaB activity.	Nicotine	67-75	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
12960242-7	2003	Neutrophils spontaneously produced NO whose production was not increased, but rather decreased by nicotine stimulation, suggesting that superoxide, produced by nicotine, generates peroxynitrite by reacting with preformed NO, which enhances the NF-kappaB activity, thereby producing IL-8.	Superoxides	136-146	C-X-C motif chemokine ligand 8	Homo sapiens	282-286
12960242-7	2003	Neutrophils spontaneously produced NO whose production was not increased, but rather decreased by nicotine stimulation, suggesting that superoxide, produced by nicotine, generates peroxynitrite by reacting with preformed NO, which enhances the NF-kappaB activity, thereby producing IL-8.	Nicotine	160-168	C-X-C motif chemokine ligand 8	Homo sapiens	282-286
12960242-7	2003	Neutrophils spontaneously produced NO whose production was not increased, but rather decreased by nicotine stimulation, suggesting that superoxide, produced by nicotine, generates peroxynitrite by reacting with preformed NO, which enhances the NF-kappaB activity, thereby producing IL-8.	Peroxynitrous Acid	180-193	C-X-C motif chemokine ligand 8	Homo sapiens	282-286
12960242-10	2003	In conclusion, nicotine stimulates neutrophil-IL-8 production via nAChR by generating peroxynitrite and subsequent NF-kappaB activation, and the IL-8 appears to contribute to leukocytosis in tobacco smokers.	Nicotine	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
12960242-10	2003	In conclusion, nicotine stimulates neutrophil-IL-8 production via nAChR by generating peroxynitrite and subsequent NF-kappaB activation, and the IL-8 appears to contribute to leukocytosis in tobacco smokers.	Peroxynitrous Acid	86-99	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
14666025-7	2003	RESULTS: Both epsilon-aminocaproic acid and aprotinin administration resulted in significant (P &lt;.05) reductions in D-dimer and interleukin-8 levels compared with saline.	Aminocaproic Acid	14-39	C-X-C motif chemokine ligand 8	Homo sapiens	131-144
14666025-10	2003	CONCLUSIONS: When dosed in a similar manner, epsilon-aminocaproic acid seems to be as effective as aprotinin at reducing interleukin-6 and interleukin-8 levels in patients undergoing primary coronary artery bypass graft surgery.	Aminocaproic Acid	45-70	C-X-C motif chemokine ligand 8	Homo sapiens	139-152
14600463-1	2003	HYPOTHESIS: This study investigates the function of the diastrophic dysplasia sulfate transporter (DTDST) in otosclerotic bone and the effect on it of sodium fluoride (NaF).	Sodium Fluoride	151-166	C-X-C motif chemokine ligand 8	Homo sapiens	168-171
14600463-10	2003	NaF (10(-6)M, 1 hr) inhibited sulfate uptake by the otosclerotic stapes and EAC cells but not by control samples.	Sulfates	30-37	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
14600463-5	2003	Sulfate uptake was quantified under basal conditions and with NaF.	Sulfates	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	62-65
14600463-6	2003	The NaF signaling pathways were investigated using forskolin and verapamil.	Colforsin	51-60	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
14600463-6	2003	The NaF signaling pathways were investigated using forskolin and verapamil.	Verapamil	65-74	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
14586044-8	2003	RESULTS: Resveratrol inhibited basal release of IL-8 in smokers and patients with COPD by 94% and 88% respectively, and inhibited GM-CSF release by 79% and 76% respectively.	Resveratrol	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
14586044-11	2003	In addition, resveratrol inhibited CSM stimulated IL-8 release by 61% and 51% respectively in smokers and COPD patients, and inhibited GM-CSF release by 49% for both subject groups.	Resveratrol	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
14595591-6	2003	In addition, peyote extract induced up to 1.85-, 2.29- and 1.89-fold increases in mRNA signal of IL-1, IL-6 and IL-8 by human leukocytes.	Mescaline	13-19	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
14586044-10	2003	Resveratrol reduced IL-1beta stimulated IL-8 and GM-CSF release in both smokers and COPD patients to below basal levels.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
14728888-0	2003	[Interleukin-8 gene expression before and after the pulse treatment with methylprednisolone in primary nephrotic syndrome of children].	Methylprednisolone	73-91	C-X-C motif chemokine ligand 8	Homo sapiens	1-14
14728888-3	2003	The purpose of the study was to evaluate the serum concentration and mRNA expression of IL-8 before and after the methylprednisolone pulse therapy (MPT) in PNS.	Methylprednisolone	114-132	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
14728888-21	2003	Methylprednisolone pulse therapy in PNS was able to inhibit the protein production and PBMC mRNA expression of IL-8, so the therapeutic mechanism of MPT in PNS might be associated with the inhibition of IL-8 expression.	Methylprednisolone	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
14728888-21	2003	Methylprednisolone pulse therapy in PNS was able to inhibit the protein production and PBMC mRNA expression of IL-8, so the therapeutic mechanism of MPT in PNS might be associated with the inhibition of IL-8 expression.	Methylprednisolone	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
14559242-6	2003	Telithromycin selectively inhibited the IL-6 and IL-8 production from Stx-stimulated (but not LPS-stimulated) monocytes.	telithromycin	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
14556981-4	2003	Fluticasone propionate, at the two concentrations tested (10 and 100 nM), was more effective in inhibiting the "IL-4 plus TNF-alpha-induced" ICAM-1 expression than VCAM-1 expression (P&lt;0.05) and in downregulating RANTES than IL-8 or GM-CSF secretion (P&lt;0.05).	Fluticasone	0-22	C-X-C motif chemokine ligand 8	Homo sapiens	228-232
14550286-3	2003	Glucose (up to 35mM) increased secretion of PAI-1 (p&lt;0.01) and IL-8 (p&lt;0.01), but not TNF-alpha, in a dose- and time-dependent manner.	Glucose	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
14550286-5	2003	Glucosamine (5mM) decreased production of PAI-1 (p&lt;0.05) and IL-8 (p&lt;0.05), indicating that the hexosamine biosynthesis pathway is not involved in the glucose-induced increment in adipokine secretion.	Glucosamine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
14550286-6	2003	The present data demonstrate that glucose increases PAI-1 and IL-8 secretion.	Glucose	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
13679236-7	2003	Moxifloxacin inhibited the release of TNFalpha, IL-1, IL-6, and IL-8 in a concentration-dependent manner across a range of 0.004 to 4 microg/mL.	Moxifloxacin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
14763781-0	2003	Fluoride release from NaF- and AmF-impregnated toothpicks and dental flosses in vitro and in vivo.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	22-25
14550561-3	2003	We now show that synthetic poly-L-histidine (Hn) binds to LPS and abrogates the release of the proinflammatory cytokine interleukin-8 (IL-8) in LPS-stimulated human whole blood.	polyhistidine	27-43	C-X-C motif chemokine ligand 8	Homo sapiens	120-133
14550561-3	2003	We now show that synthetic poly-L-histidine (Hn) binds to LPS and abrogates the release of the proinflammatory cytokine interleukin-8 (IL-8) in LPS-stimulated human whole blood.	polyhistidine	27-43	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
14550561-3	2003	We now show that synthetic poly-L-histidine (Hn) binds to LPS and abrogates the release of the proinflammatory cytokine interleukin-8 (IL-8) in LPS-stimulated human whole blood.	polyhistidine	45-47	C-X-C motif chemokine ligand 8	Homo sapiens	120-133
14550561-3	2003	We now show that synthetic poly-L-histidine (Hn) binds to LPS and abrogates the release of the proinflammatory cytokine interleukin-8 (IL-8) in LPS-stimulated human whole blood.	polyhistidine	45-47	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
14763781-9	2003	An interdental brush dipped in 0.2% NaF gel and a mouthrinse with 0.2% NaF resulted in elevated fluoride concentrations at the same level as when multiple toothpicks were used.	Fluorides	96-104	C-X-C motif chemokine ligand 8	Homo sapiens	36-39
14763781-9	2003	An interdental brush dipped in 0.2% NaF gel and a mouthrinse with 0.2% NaF resulted in elevated fluoride concentrations at the same level as when multiple toothpicks were used.	Fluorides	96-104	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
14672330-5	2003	RESULTS: Simple regression analysis demonstrated a significant negative correlation between the concentrations of IL-8 and oxygen in FF (r = 0.50, P &lt; 0.0001).	Oxygen	123-129	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
12907466-8	2003	Sugar phloem unloading was significantly inhibited by the inclusion of either 7.5 mm NaF or 2.5 mm PCMB in the buffer solution.	Sugars	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
14612204-0	2003	Hypoxia increases 25-hydroxycholesterol-induced interleukin-8 protein secretion in human macrophages.	25-hydroxycholesterol	18-39	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
14530017-9	2003	ONO-6818 significantly reduced interleukin 8 and C5b-9 production.	ONO 6818	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	31-44
14530017-12	2003	CONCLUSIONS: Inhibition of neutrophil elastase activity with ONO-6818 reduces further interleukin 8 production and the formation of the complement membrane attack complex, and this results in a reduction of neutrophil elastase levels during simulated extracorporeal circulation.	ONO 6818	61-69	C-X-C motif chemokine ligand 8	Homo sapiens	86-99
14612204-3	2003	The aim of this study was to investigate the effect of hypoxia on the secretion of IL-8 by oxysterol-stimulated macrophages.	Oxysterols	91-100	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
14612204-4	2003	Hypoxia enhances 25-hydroxycholesterol (25-OH-chol)-induced IL-8 secretion in human monocyte-derived macrophages.	25-hydroxycholesterol	17-38	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
14612204-4	2003	Hypoxia enhances 25-hydroxycholesterol (25-OH-chol)-induced IL-8 secretion in human monocyte-derived macrophages.	25-oh-chol	40-50	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
14505796-4	2003	Human CXCL8 produced in vivo neutrophilia, chemotaxis and intracellular calcium release of guinea pig neutrophils.	Calcium	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	6-11
14612204-8	2003	These observations suggest that similar intracellular signalling pathways are used for both 25-OH-chol-induced IL-8 expression and hypoxia-induced IL-8 expression.	25-oh-chol	92-102	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
14612204-9	2003	Thus, hypoxia in atherosclerotic plaques may increase the secretion of IL-8 from oxysterol-containing foam cells, which subsequently may accelerate the progression of atherosclerosis.	Oxysterols	81-90	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
12919783-4	2003	The findings suggest that GEP and high-sulfur DEP induced the production of similar levels of IL-8 by unprimed A549 cells.	Sulfur	39-45	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
14522840-3	2003	Novel data show that oATP reduces NFkappaB activation and IL-8 release in cells lacking P2X7R, thus suggesting that some anti-inflammatory effects of oATP may not be due to blockade of the P2X7R.	2',3'-dialdehyde ATP	21-25	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
14522842-5	2003	Attenuation of TNF-alpha-stimulated IL-8 secretion by oATP was similar in wild-type HEK cells or HEK cells stably expressing recombinant P2X7R.	2',3'-dialdehyde ATP	54-58	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
12919783-5	2003	The level of IL-8 produced by unprimed A549 cells in response to low-sulfur DEP was found lower than that produced in response to high-sulfur DEP and GEP.	Sulfur	69-75	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
12919783-5	2003	The level of IL-8 produced by unprimed A549 cells in response to low-sulfur DEP was found lower than that produced in response to high-sulfur DEP and GEP.	Sulfur	135-141	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
14519149-5	2003	RESULTS: Following RV16-infection, a significant increase in IL-8 was observed in the placebo- and budesonide-treated asthmatics (P=0.033 and 0.037, respectively), whereas IL-1beta only increased in the two asthma groups combined (P=0.035).	Budesonide	99-109	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
14553834-0	2003	8-isoprostane increases expression of interleukin-8 in human macrophages through activation of mitogen-activated protein kinases.	8-epi-prostaglandin F2alpha	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	38-51
14553834-3	2003	We therefore investigated the effects of 8-isoprostane on the expression of inflammatory chemokines with consciousness on IL-8 (mRNA and protein) in human macrophages.	8-epi-prostaglandin F2alpha	41-54	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
14553834-5	2003	METHODS AND RESULTS: 8-isoprostane (10 microM) induced IL-8 expression (mRNA and protein), measured by real-time quantitative RT-PCR and enzyme immunoassay, respectively, in both THP-1 macrophages and human monocyte-derived macrophages.	8-epi-prostaglandin F2alpha	21-34	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
14553834-8	2003	Furthermore, the ERK 1/2 inhibitor, PD98059, and the p38 MAPK inhibitor, SB203580, markedly reduced 8-isoprostane-induced IL-8 expression (mRNA and protein), while inhibition of NF-kappaB activation and translocation had no significant effect on IL-8 expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	36-43	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
14553834-8	2003	Furthermore, the ERK 1/2 inhibitor, PD98059, and the p38 MAPK inhibitor, SB203580, markedly reduced 8-isoprostane-induced IL-8 expression (mRNA and protein), while inhibition of NF-kappaB activation and translocation had no significant effect on IL-8 expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	36-43	C-X-C motif chemokine ligand 8	Homo sapiens	246-250
14553834-8	2003	Furthermore, the ERK 1/2 inhibitor, PD98059, and the p38 MAPK inhibitor, SB203580, markedly reduced 8-isoprostane-induced IL-8 expression (mRNA and protein), while inhibition of NF-kappaB activation and translocation had no significant effect on IL-8 expression.	SB 203580	73-81	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
14553834-8	2003	Furthermore, the ERK 1/2 inhibitor, PD98059, and the p38 MAPK inhibitor, SB203580, markedly reduced 8-isoprostane-induced IL-8 expression (mRNA and protein), while inhibition of NF-kappaB activation and translocation had no significant effect on IL-8 expression.	SB 203580	73-81	C-X-C motif chemokine ligand 8	Homo sapiens	246-250
14553834-8	2003	Furthermore, the ERK 1/2 inhibitor, PD98059, and the p38 MAPK inhibitor, SB203580, markedly reduced 8-isoprostane-induced IL-8 expression (mRNA and protein), while inhibition of NF-kappaB activation and translocation had no significant effect on IL-8 expression.	8-epi-prostaglandin F2alpha	100-113	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
14553834-8	2003	Furthermore, the ERK 1/2 inhibitor, PD98059, and the p38 MAPK inhibitor, SB203580, markedly reduced 8-isoprostane-induced IL-8 expression (mRNA and protein), while inhibition of NF-kappaB activation and translocation had no significant effect on IL-8 expression.	8-epi-prostaglandin F2alpha	100-113	C-X-C motif chemokine ligand 8	Homo sapiens	246-250
14553834-9	2003	CONCLUSIONS: We show that 8-isoprostane increases IL-8 expression in human macrophages involving both ERK 1/2 and p38 MAPK, but not NF-kappaB signaling pathway.	8-epi-prostaglandin F2alpha	26-39	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
14500470-7	2003	The results indicated that the p38 mitogen-activated protein kinase (MAPK) and Src-dependent Raf-1-Mek1/2-extracellular signal-regulated kinase mitogen-activated protein kinase (ERK MAPK) pathways are required for NTHI-induced IL-8 production.	nthi	214-218	C-X-C motif chemokine ligand 8	Homo sapiens	227-231
14627349-14	2003	(4) COX-2, PPARgamma, Bcl-2, and survivin were overexpressed in gastric tumor, but the inhibition of COX-2 activity by Vioxx resulted in a significant reduction in serum and tumor levels of progastrin and gastrin and serum IL-8 and TNF-alpha levels, suggesting that gastrin and proinflammatory cytokines could mediate the up-regulation of COX-2 in gastric cancerogenesis.	rofecoxib	119-124	C-X-C motif chemokine ligand 8	Homo sapiens	223-227
12946434-0	2003	The diesel exhaust component pyrene induces expression of IL-8 but not of eotaxin.	pyrene	29-35	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
12946434-3	2003	We have characterized the influence of pyrene, a polycyclic aromatic hydrocarbon (PAH) contained, for example, in diesel exhaust particles (DEP), on transcription and secretion of the chemokines interleukin-8 (IL-8) and eotaxin.	pyrene	39-45	C-X-C motif chemokine ligand 8	Homo sapiens	195-208
12946434-3	2003	We have characterized the influence of pyrene, a polycyclic aromatic hydrocarbon (PAH) contained, for example, in diesel exhaust particles (DEP), on transcription and secretion of the chemokines interleukin-8 (IL-8) and eotaxin.	pyrene	39-45	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
12946434-3	2003	We have characterized the influence of pyrene, a polycyclic aromatic hydrocarbon (PAH) contained, for example, in diesel exhaust particles (DEP), on transcription and secretion of the chemokines interleukin-8 (IL-8) and eotaxin.	Polycyclic Aromatic Hydrocarbons	49-80	C-X-C motif chemokine ligand 8	Homo sapiens	195-208
12946434-3	2003	We have characterized the influence of pyrene, a polycyclic aromatic hydrocarbon (PAH) contained, for example, in diesel exhaust particles (DEP), on transcription and secretion of the chemokines interleukin-8 (IL-8) and eotaxin.	Polycyclic Aromatic Hydrocarbons	82-85	C-X-C motif chemokine ligand 8	Homo sapiens	195-208
12946434-6	2003	Promoter activity, mRNA production and protein expression of IL-8 were increased by pyrene.	pyrene	84-90	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
12950106-4	2003	Furthermore, GTPgammaS and NaF stimulated cAMP, but GDPbetaS and mastoparan had no apparent effect, consistent with recent evidence that G(s), but not G(i), contributes to AC/cAMP regulation in uncapacitated cells.	Cyclic AMP	42-46	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
14514769-5	2003	Among the toxic dioxins proposed by the World Health Organization (WHO) in 1998, 2,3",4,4",5-pentachlorobiphenyl (PCB 118) and OCDD, which were mainly found in saliva, significantly induced IL-8 production in HGEC.	Dioxins	16-23	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
14514769-5	2003	Among the toxic dioxins proposed by the World Health Organization (WHO) in 1998, 2,3",4,4",5-pentachlorobiphenyl (PCB 118) and OCDD, which were mainly found in saliva, significantly induced IL-8 production in HGEC.	2,3',4,4',5-pentachlorobiphenyl	81-112	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
14514769-5	2003	Among the toxic dioxins proposed by the World Health Organization (WHO) in 1998, 2,3",4,4",5-pentachlorobiphenyl (PCB 118) and OCDD, which were mainly found in saliva, significantly induced IL-8 production in HGEC.	Polychlorinated Biphenyls	114-117	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
14514769-5	2003	Among the toxic dioxins proposed by the World Health Organization (WHO) in 1998, 2,3",4,4",5-pentachlorobiphenyl (PCB 118) and OCDD, which were mainly found in saliva, significantly induced IL-8 production in HGEC.	octachlorodibenzo-4-dioxin	127-131	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
14514769-6	2003	Furthermore, these two dioxins markedly augmented IL-8 production stimulated with fimbriae from Porphyromonas gingivalis, which is well-known as a pathogenic factor in periodontal diseases.	Dioxins	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
12777636-10	2003	Furthermore, inhibition was dependent on the stimulus; IL-6, IL-8, IL-1 beta and TNF alpha production induced by LOS or SAC was only slightly decreased by methotrexate.	Methotrexate	155-167	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
13679572-6	2003	IL-8 secretion was inhibited by pertussis toxin and a selective p38 kinase inhibitor, SB203580.	SB 203580	86-94	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12925902-8	2003	The norepinephrine dosage used in the ICU correlated with plasma IL-8 levels 2 hours after arriving in the ICU (r = 0.56, p = 0.031).	Norepinephrine	4-18	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
13679572-7	2003	The CysLT2 response may permit the cys-LTs and nucleotides generated in infection and tissue injury to elicit IL-8 generation by hMCs, potentially leading to neutrophilic infiltration, a characteristic of aerosol challenge-induced late-phase responses and of sudden death associated with asthma.	cysteinyl-leukotriene	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
12763941-3	2003	The inhibition of PI3K activity with wortmannin showed that rate of pseudopod extension stimulated with N-formyl-Met-Leu-Phe (fMLP was mostly dependent on PI3K, while the rate of interleukin-8 (IL-8)-stimulated pseudopod extension was less dependent on PI3K.	Wortmannin	37-47	C-X-C motif chemokine ligand 8	Homo sapiens	179-192
12951051-0	2003	Reduction of chemokine IL-8 and RANTES expression in human bronchial epithelial cells by a sea-water derived saline through inhibited nuclear factor-kappaB activation.	Water	95-100	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
12951051-0	2003	Reduction of chemokine IL-8 and RANTES expression in human bronchial epithelial cells by a sea-water derived saline through inhibited nuclear factor-kappaB activation.	Sodium Chloride	109-115	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
12951051-3	2003	Exposure of BECs to ISW saline caused a significant decrease in IL-8 and RANTES gene expression and protein production as compared to that observed with 0.9% NaCl saline.	Sodium Chloride	24-30	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
12763941-3	2003	The inhibition of PI3K activity with wortmannin showed that rate of pseudopod extension stimulated with N-formyl-Met-Leu-Phe (fMLP was mostly dependent on PI3K, while the rate of interleukin-8 (IL-8)-stimulated pseudopod extension was less dependent on PI3K.	N-Formylmethionine Leucyl-Phenylalanine	104-124	C-X-C motif chemokine ligand 8	Homo sapiens	179-192
12763941-3	2003	The inhibition of PI3K activity with wortmannin showed that rate of pseudopod extension stimulated with N-formyl-Met-Leu-Phe (fMLP was mostly dependent on PI3K, while the rate of interleukin-8 (IL-8)-stimulated pseudopod extension was less dependent on PI3K.	N-Formylmethionine Leucyl-Phenylalanine	104-124	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
12816876-5	2003	Three- to 4-fold increases in MCP-1 and IL-8 release were observed at endotoxin concentrations of 100 pg/mL; these increases were inhibited by the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin.	Atorvastatin	205-217	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
14666669-1	2003	We have recently found that millimolar concentrations of sodium fluoride (NaF) induced apoptotic cell death, characterized by caspase activation and DNA fragmentation, in tumor cell lines.	Sodium Fluoride	57-72	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
12824191-6	2003	Both specific inhibitors of p38 MAP kinase and sodium vanadate, a potent protein-tyrosine phosphatase inhibitor, blocked IL-8 production in a dose-dependent manner.	Vanadates	47-62	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
12921778-4	2003	We show that okadaic acid (OA), an inhibitor of protein phosphatases PP1 and PP2A, induces sustained activation of NFkappaB and degradation of the nuclear IkappaBalpha, and increases interleukin-8 expression in the neutrophils.	Okadaic Acid	27-29	C-X-C motif chemokine ligand 8	Homo sapiens	183-196
12921778-4	2003	We show that okadaic acid (OA), an inhibitor of protein phosphatases PP1 and PP2A, induces sustained activation of NFkappaB and degradation of the nuclear IkappaBalpha, and increases interleukin-8 expression in the neutrophils.	Okadaic Acid	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	183-196
14666669-8	2003	During the cell death induction in human promyelocytic leukemia HL-60 cells by NaF, the consumption of glucose rapidly declined, followed by a decline in the consumption of major amino acids.	Glucose	103-110	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
14666669-9	2003	The present study suggests that the cytotoxic activity of NaF is not regulated by the redox mechanism, but rather linked to the rapid decline in glucose consumption at early stage.	Glucose	145-152	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
12940901-2	2003	Many water-soluble mediators with pro- and anti-inflammatory action such as TNF, IL-6, IL-8, and IL-10 play a strategic role in septic syndrome.	Water	5-10	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
12941142-6	2003	Furthermore, IL-8 production in PBMC stimulated with the active monosaccharide lipid A analogues as well as compound 506 was clearly inhibited by the monoclonal antibody to human TLR4.	PBMC	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
14621001-4	2003	The corrosion resistance of titanium decreased as the NaF concentration increased and as pH decreased.	Titanium	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
12970036-10	2003	RESULTS: and measurements: EBC NO(2)(-) correlated well with VT (milliliters per kilogram of BW; r = 0.79, p &lt; 0.0001) and expiratory minute volume (r = 0.60, p &lt; 0.0001) but not with other ventilatory parameters or parameters of pulmonary (EBC IL-6, EBC IL-8) or systemic (serum IL-6, IL-8, and procalcitonin) inflammation.	NSC638702	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	261-265
12970036-10	2003	RESULTS: and measurements: EBC NO(2)(-) correlated well with VT (milliliters per kilogram of BW; r = 0.79, p &lt; 0.0001) and expiratory minute volume (r = 0.60, p &lt; 0.0001) but not with other ventilatory parameters or parameters of pulmonary (EBC IL-6, EBC IL-8) or systemic (serum IL-6, IL-8, and procalcitonin) inflammation.	NSC638702	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	292-296
12941142-6	2003	Furthermore, IL-8 production in PBMC stimulated with the active monosaccharide lipid A analogues as well as compound 506 was clearly inhibited by the monoclonal antibody to human TLR4.	Monosaccharides	64-78	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
12941142-6	2003	Furthermore, IL-8 production in PBMC stimulated with the active monosaccharide lipid A analogues as well as compound 506 was clearly inhibited by the monoclonal antibody to human TLR4.	Lipid A	79-86	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
14566081-0	2003	Poly-C specific ribonuclease activity correlates with increased concentrations of IL-6, IL-8 and sTNFR55/sTNFR75 in plasma of patients with acute pancreatitis.	Poly C	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
12928590-6	2003	Diphenylene iodonium, an inhibitor of NADPH oxidase, significantly inhibited CMV-induced IL-8 production and promotion of serum-induced DNA synthesis.	diphenyleneiodonium	0-20	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
14502144-9	2003	Interleukin-6 and interleukin-8 concentrations correlated with the length of inotropic support, as well as with the length of mechanical ventilation (r &gt;.70, P &lt;/=.0006), and were inversely related to the ratio of arterial oxygen tension to fraction of inspired oxygen.	Oxygen	229-235	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
14502144-9	2003	Interleukin-6 and interleukin-8 concentrations correlated with the length of inotropic support, as well as with the length of mechanical ventilation (r &gt;.70, P &lt;/=.0006), and were inversely related to the ratio of arterial oxygen tension to fraction of inspired oxygen.	Oxygen	268-274	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
12946798-7	2003	RESULTS: Leukocytes incubated with Dextran-70 demonstrated greater than a 6-fold (p &lt; 0.05) increase in the expression of interleukin-8, growth-regulated oncogenes alpha and beta, L-selectin, superoxide dismutase, tumor necrosis factor-alpha (TNF-alpha), and mitogen-activated protein kinase 3.	Dextrans	35-45	C-X-C motif chemokine ligand 8	Homo sapiens	125-138
14558594-2	2003	The results show that thalidomide inhibits endotelial cell proliferation induced by bFGF and VEGF, more so if the cells are grown on vitronectin; moreover, treatment with thalidomide reduces the release of MMP-2 and IL-8 by endothelial cells, suggesting a further pathway for the antiangiogenic activity of drug.	Thalidomide	22-33	C-X-C motif chemokine ligand 8	Homo sapiens	216-220
14558594-2	2003	The results show that thalidomide inhibits endotelial cell proliferation induced by bFGF and VEGF, more so if the cells are grown on vitronectin; moreover, treatment with thalidomide reduces the release of MMP-2 and IL-8 by endothelial cells, suggesting a further pathway for the antiangiogenic activity of drug.	Thalidomide	171-182	C-X-C motif chemokine ligand 8	Homo sapiens	216-220
12947130-10	2003	QPT was negatively correlated with CXCL8 and positively correlated with IGF-I and lung transfer factor in hospitalised and in stable patients.	qpt	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	35-40
12626343-1	2003	Peroxynitrite, formed by nitric oxide and superoxide, has been shown to nitrate and reduce the function of proinflammatory proteins such as interleukin (IL)-8, monocyte chemoattractant protein-1, and eotaxin, but in contrast, to enhance the function of the anti-inflammatory cytokine IL-10 in reducing IL-1 release from blood monocytes.	Peroxynitrous Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	140-158
12881478-8	2003	These data indicate that pathophysiological levels of Hcy can alter human monocyte function by upregulating MCP-1 and IL-8 expression and secretion via enhanced formation of intracellular ROS originated from NAD(P)H oxidase source via calmodulin or protein kinase C signaling pathways and that Hcy-induced ROS subsequently activates mitogen-activated protein kinase (p38 and ERK1/2) and nuclear factor-kappaB in a PPARgamma activator-sensitive manner.	Homocysteine	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
12915334-12	2003	In these experiments EPA was the omega-3 fatty acid responsible for improvement, with distinct effects on inhibition of cytokines formation (IL-1 to IL-6, IL-8, TFN-alpha, GM-CSF), decreased induction of proinflammatory adhesion molecules (selectines, intercellular adhesions molecule-1 (ICAM-1)), and degrading enzymes (e.g. phospholipase A2, cyclooxygenase-2, inducible NO-synthetase).	Fatty Acids, Omega-3	33-51	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
12901923-0	2003	Synthesis and structure-activity relationship of 2-amino-3-heteroaryl-quinoxalines as non-peptide, small-molecule antagonists for interleukin-8 receptor.	2-amino-3-heteroaryl-quinoxalines	49-82	C-X-C motif chemokine ligand 8	Homo sapiens	130-143
12902511-4	2003	In endothelial culture supernatants, IL-8 was detected in a trimolecular complex with heparan sulfate and syndecan-1.	Heparitin Sulfate	86-101	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
12902511-6	2003	Increased shedding of IL-8/heparan sulfate/syndecan-1 complexes was accompanied by inhibition of neutrophil transendothelial migration, and aprotinin, a potent plasmin inhibitor, reversed this inhibition.	heparan	27-34	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
12881478-0	2003	Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes.	Homocysteine	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	89-102
12881478-5	2003	We found that clinically relevant levels of Hcy (10 to 1000 micromol/L) increased the protein secretion and mRNA expression as well as activity of MCP-1 and IL-8 in cultured primary human monocytes.	Homocysteine	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
12626343-1	2003	Peroxynitrite, formed by nitric oxide and superoxide, has been shown to nitrate and reduce the function of proinflammatory proteins such as interleukin (IL)-8, monocyte chemoattractant protein-1, and eotaxin, but in contrast, to enhance the function of the anti-inflammatory cytokine IL-10 in reducing IL-1 release from blood monocytes.	Nitric Oxide	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	140-158
12626343-1	2003	Peroxynitrite, formed by nitric oxide and superoxide, has been shown to nitrate and reduce the function of proinflammatory proteins such as interleukin (IL)-8, monocyte chemoattractant protein-1, and eotaxin, but in contrast, to enhance the function of the anti-inflammatory cytokine IL-10 in reducing IL-1 release from blood monocytes.	Superoxides	42-52	C-X-C motif chemokine ligand 8	Homo sapiens	140-158
12873450-8	2003	Baicalin did not suppress IL-1beta-induced IL-6 and IL-8 production, but dexamethasone, baicalein, and wogonin, significantly suppressed IL-6 and IL-8 production.	Dexamethasone	73-86	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
12880609-8	2003	IL-8 and IL-6 production from stimulated biopsies significantly decreased with increasing glutamine concentration from 0.5 to 10mM, (2543 [828-3634] to 1499 [282-2617] for IL-8, 62 [22-117] to 24 [12-99] for IL-6, both P&lt;0.05), whereas IL-10 production was increased (0.7 [0.2-1.6] to 1.2 [2.6-0.5],P&lt;0.05).	Glutamine	90-99	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12880609-8	2003	IL-8 and IL-6 production from stimulated biopsies significantly decreased with increasing glutamine concentration from 0.5 to 10mM, (2543 [828-3634] to 1499 [282-2617] for IL-8, 62 [22-117] to 24 [12-99] for IL-6, both P&lt;0.05), whereas IL-10 production was increased (0.7 [0.2-1.6] to 1.2 [2.6-0.5],P&lt;0.05).	Glutamine	90-99	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
12880609-11	2003	CONCLUSIONS: Glutamine was shown in human intestinal mucosa to reduce the production of the pro-inflammatory cytokines IL-6 and IL-8, and enhance the production of the anti-inflammatory cytokine, IL-10.	Glutamine	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
12881351-10	2003	Correlation coefficients showed that the spermidine and putrescine level variations correlated with the VEGF and IL-8 content in the active PDR and PVR groups, but not in those with quiescent PDR patients, while spermine was correlated to these cytokines in PDR, but not in PVR groups.	Spermidine	41-51	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
12881351-10	2003	Correlation coefficients showed that the spermidine and putrescine level variations correlated with the VEGF and IL-8 content in the active PDR and PVR groups, but not in those with quiescent PDR patients, while spermine was correlated to these cytokines in PDR, but not in PVR groups.	Putrescine	56-66	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
12964812-0	2003	Stimulatory effect of homocysteine on interleukin-8 expression in human endothelial cells.	Homocysteine	22-34	C-X-C motif chemokine ligand 8	Homo sapiens	38-51
12964812-4	2003	The objective of the present study was to investigate the effect of homocysteine on interleukin-8 production in human endothelial cells.	Homocysteine	68-80	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
12964812-5	2003	Cells were incubated with various concentrations of homocysteine for 20 h. The gene expression was determined by real-time PCR and the interleukin-8 protein was measured by immunoassay analysis.	Homocysteine	52-64	C-X-C motif chemokine ligand 8	Homo sapiens	135-148
12964812-6	2003	Homocysteine enhanced the expression of interleukin-8 in a dose-dependent manner (181% of controls at 2.5 mmol/l homocysteine).	Homocysteine	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
12964812-6	2003	Homocysteine enhanced the expression of interleukin-8 in a dose-dependent manner (181% of controls at 2.5 mmol/l homocysteine).	Homocysteine	113-125	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
12964812-7	2003	Stimulation of gene expression was associated with a parallel increase in interleukin-8 protein synthesis (160% of controls at 5.0 mmol/l homocysteine).	Homocysteine	138-150	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
12964812-8	2003	By co-incubation of endothelial cells with homocysteine and copper sulfate, a further elevation of interleukin-8 expression (251% of controls) was observed, whereas copper sulfate alone had no stimulatory effect.	Homocysteine	43-55	C-X-C motif chemokine ligand 8	Homo sapiens	99-112
12964812-8	2003	By co-incubation of endothelial cells with homocysteine and copper sulfate, a further elevation of interleukin-8 expression (251% of controls) was observed, whereas copper sulfate alone had no stimulatory effect.	Copper Sulfate	60-74	C-X-C motif chemokine ligand 8	Homo sapiens	99-112
12964812-9	2003	In conclusion, the present study demonstrated that homocysteine altered endothelial cell function by stimulating interleukin-8 expression, suggesting a contribution of homocysteine to the initiation and progression of atherosclerosis.	Homocysteine	51-63	C-X-C motif chemokine ligand 8	Homo sapiens	113-126
12964812-9	2003	In conclusion, the present study demonstrated that homocysteine altered endothelial cell function by stimulating interleukin-8 expression, suggesting a contribution of homocysteine to the initiation and progression of atherosclerosis.	Homocysteine	168-180	C-X-C motif chemokine ligand 8	Homo sapiens	113-126
12873450-8	2003	Baicalin did not suppress IL-1beta-induced IL-6 and IL-8 production, but dexamethasone, baicalein, and wogonin, significantly suppressed IL-6 and IL-8 production.	baicalein	88-97	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
12873450-8	2003	Baicalin did not suppress IL-1beta-induced IL-6 and IL-8 production, but dexamethasone, baicalein, and wogonin, significantly suppressed IL-6 and IL-8 production.	wogonin	103-110	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
12873450-9	2003	Elevation of IL-6 and IL-8 mRNA was not suppressed by baicalin but was significantly suppressed by dexamethasone, baicalein, and wogonin.	Dexamethasone	99-112	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
12748173-0	2003	Transcriptional regulation of interleukin (IL)-8 by bradykinin in human airway smooth muscle cells involves prostanoid-dependent activation of AP-1 and nuclear factor (NF)-IL-6 and prostanoid-independent activation of NF-kappaB.	Prostaglandins	108-118	C-X-C motif chemokine ligand 8	Homo sapiens	30-48
12748173-0	2003	Transcriptional regulation of interleukin (IL)-8 by bradykinin in human airway smooth muscle cells involves prostanoid-dependent activation of AP-1 and nuclear factor (NF)-IL-6 and prostanoid-independent activation of NF-kappaB.	Prostaglandins	181-191	C-X-C motif chemokine ligand 8	Homo sapiens	30-48
12748173-7	2003	Furthermore, exogenous prostaglandin E2 stimulated AP-1 and NF-IL-6 binding to the IL-8 promoter.	Dinoprostone	23-39	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
12748173-6	2003	Indomethacin, a cyclooxygenase inhibitor, partially inhibited IL-8 release and the promoter binding of AP-1 and NF-IL-6, but not NF-kappaB.	Indomethacin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
12748173-10	2003	Transcriptional activation of the IL-8 promoter by BK involves the prostanoid-independent activation of NF-kappaB, and prostanoid-dependent activation of AP-1 and NF-IL-6 plays a key role in augmenting the response.	Prostaglandins	67-77	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
12953027-10	2003	The ratio between the total sodium concentration in the ultrafiltrate (NaF(uf)) and NaF(pw) (alpha) at the post-reinfusion site was 0.96 and decreased to 0.94 when NaF(pw) values at the pre-reinfusion site were considered.	Sodium	28-34	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
12897563-4	2003	Further, the effects of clarithromycin, a 14-member ring macrolide, on IL-8 gene expression and nuclear factor-kappa B (NF-kappa B) activation in adenoidal fibroblasts were evaluated.	Clarithromycin	24-38	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
12897563-11	2003	Treatment of cells with the NF-kappa B inhibitor N-tosyl-(L)-phenylalanine chloromethyl ketone, as well as with clarithromycin, reduced expression of IL-8 and NF-kappa B activity in a dose-dependent manner.	Tosylphenylalanyl Chloromethyl Ketone	49-94	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
12897563-11	2003	Treatment of cells with the NF-kappa B inhibitor N-tosyl-(L)-phenylalanine chloromethyl ketone, as well as with clarithromycin, reduced expression of IL-8 and NF-kappa B activity in a dose-dependent manner.	Clarithromycin	112-126	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
12897563-13	2003	The inhibitory effects of clarithromycin on NF-kappa B activation and IL-8 production in adenoidal fibroblasts might explain, in part, the mechanism of this drug in improving otitis media with effusion.	Clarithromycin	26-40	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
12939465-0	2003	Dacarbazine causes transcriptional up-regulation of interleukin 8 and vascular endothelial growth factor in melanoma cells: a possible escape mechanism from chemotherapy.	Dacarbazine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
12939465-10	2003	Metastatic melanoma cell lines secreting high levels of IL-8 and VEGF were more resistant to DTIC than early primary melanomas secreting low levels of the cytokines.	Dacarbazine	93-97	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
12939465-11	2003	In addition, transfection of the primary cutaneous melanoma SB-2 cells with the IL-8 gene rendered them resistant to the cytotoxic effect of the drug, whereas the addition of IL-8-neutralizing antibody to metastatic melanoma cells lowered their sensitivity to DTIC.	Dacarbazine	260-264	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
12939465-12	2003	Taken together, our data demonstrate that DTIC can cause melanoma cells to secrete IL-8 and VEGF, which might render them resistant to the cytotoxic effects of the drug.	Dacarbazine	42-46	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
12939465-13	2003	We propose that combination treatment with anti-VEGF/IL-8 agents may potentiate the therapeutic effects of DTIC.	Dacarbazine	107-111	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
12953027-10	2003	The ratio between the total sodium concentration in the ultrafiltrate (NaF(uf)) and NaF(pw) (alpha) at the post-reinfusion site was 0.96 and decreased to 0.94 when NaF(pw) values at the pre-reinfusion site were considered.	Sodium	28-34	C-X-C motif chemokine ligand 8	Homo sapiens	84-87
12894071-6	2003	IL-8 production stimulated with histamine was also suppressed by cetirizine, ketotifen, and olopatadine.	Histamine	32-41	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12953027-10	2003	The ratio between the total sodium concentration in the ultrafiltrate (NaF(uf)) and NaF(pw) (alpha) at the post-reinfusion site was 0.96 and decreased to 0.94 when NaF(pw) values at the pre-reinfusion site were considered.	Sodium	28-34	C-X-C motif chemokine ligand 8	Homo sapiens	84-87
12894071-6	2003	IL-8 production stimulated with histamine was also suppressed by cetirizine, ketotifen, and olopatadine.	Cetirizine	65-75	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12883201-11	2003	The cold/rewarming-induced IL-8 production was reduced to approximately 50% by introducing an antisense oligonucleotide for the p65 subunit of NF-kappaB and by treatment with N-acetyl-leucinyl-leucinyl-norleucinal and pyrrolidine dithiocarbamate.	Oligonucleotides	104-119	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
12894071-6	2003	IL-8 production stimulated with histamine was also suppressed by cetirizine, ketotifen, and olopatadine.	Ketotifen	77-86	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12894071-6	2003	IL-8 production stimulated with histamine was also suppressed by cetirizine, ketotifen, and olopatadine.	Olopatadine Hydrochloride	92-103	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12913774-8	2003	CONCLUSION: Dexamethasone does not cause an impaired decline of tracheal RSV but lowers IL-8 of children mechanically ventilated for RSV lower respiratory tract infection, potentially leading to less inflammation and reduced phagocyte activation.	Dexamethasone	12-25	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
12947311-9	2003	IL-8 production in response to lipopolysaccharide and xanthine oxidase was inhibited significantly by hemin exposure, although PGI(2) production was not affected.	Hemin	102-107	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12865660-0	2003	Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses.	Copper	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	47-60
12865660-1	2003	Endogenous copper can play an important role in postischemic reperfusion injury, a condition associated with endothelial cell activation and increased interleukin 8 (IL-8) production.	Copper	11-17	C-X-C motif chemokine ligand 8	Homo sapiens	151-164
12865660-1	2003	Endogenous copper can play an important role in postischemic reperfusion injury, a condition associated with endothelial cell activation and increased interleukin 8 (IL-8) production.	Copper	11-17	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
12865660-3	2003	No previous reports have indicated that copper has a direct role in stimulating human endothelial IL-8 secretion.	Copper	40-46	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
12865660-4	2003	Increased IL-8 in the culture medium of human umbilical vein (HUVEC), lung microvascular, and iliac artery endothelial cells was observed 24 h after the addition of 10 to 50 microM CuCl2 (cupric ions).	cupric chloride	181-186	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
12865660-5	2003	HUVEC IL-8 induction by copper was higher than by 50 pg/mL tumor necrosis factor-alpha, whereas 50 pg/mL IL-1beta and 1 ng/mL platelet-activating factor did not stimulate IL-8 production or release.	Copper	24-30	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
12865660-6	2003	HUVEC IL-8 mRNA increased 3 h after CuCl2 stimulation and remained elevated after 24 h, implying sustained transcriptional activation.	cupric chloride	36-41	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
12865660-8	2003	Cu(II) appeared to be the primary copper ion responsible for the observed increase in IL-8 because a specific high-affinity Cu(II)-binding peptide, d-Asp-d-Ala-d-His-d-Lys (d-DAHK), completely abolished this effect in a dose-dependent manner.	cu(ii)	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
12865660-8	2003	Cu(II) appeared to be the primary copper ion responsible for the observed increase in IL-8 because a specific high-affinity Cu(II)-binding peptide, d-Asp-d-Ala-d-His-d-Lys (d-DAHK), completely abolished this effect in a dose-dependent manner.	Copper	34-40	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
12865660-8	2003	Cu(II) appeared to be the primary copper ion responsible for the observed increase in IL-8 because a specific high-affinity Cu(II)-binding peptide, d-Asp-d-Ala-d-His-d-Lys (d-DAHK), completely abolished this effect in a dose-dependent manner.	cu(ii)	124-130	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
12865660-8	2003	Cu(II) appeared to be the primary copper ion responsible for the observed increase in IL-8 because a specific high-affinity Cu(II)-binding peptide, d-Asp-d-Ala-d-His-d-Lys (d-DAHK), completely abolished this effect in a dose-dependent manner.	d-asp-d-ala-d-his	148-165	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
12865660-8	2003	Cu(II) appeared to be the primary copper ion responsible for the observed increase in IL-8 because a specific high-affinity Cu(II)-binding peptide, d-Asp-d-Ala-d-His-d-Lys (d-DAHK), completely abolished this effect in a dose-dependent manner.	D-Lysine	166-171	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
12865660-8	2003	Cu(II) appeared to be the primary copper ion responsible for the observed increase in IL-8 because a specific high-affinity Cu(II)-binding peptide, d-Asp-d-Ala-d-His-d-Lys (d-DAHK), completely abolished this effect in a dose-dependent manner.	dahk	175-179	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
12865660-9	2003	These results suggest that Cu(II) may induce endothelial IL-8 by a mechanism independent of known Cu(I) generation of reactive oxygen species.	cu(ii)	27-33	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
12865660-10	2003	Furthermore, in vivo studies are warranted to determine if copper is involved in the pathogenesis of systemic inflammation and if Cu(II) chelation can reduce this IL-8-induced endothelial inflammatory response.	cu(ii)	130-136	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
14642174-4	2003	RESULTS: There was a significant increase in plasma levels of IL-8 and both adhesion molecules [IL-8 (247.4 +/- 84.2) microg/L (P &lt; 0.01); sICAM-1 (530.3 +/- 286.1) microg/L (P = 0.002 7); sVCAM-1 (575.3 +/- 350.4) microg/L (P = 0.001 3)] during the mobilization process; furthermore, IL-8 and sVCAM-1 concentration in the patient"s plasma was paralleled to the numbers of CD(34)(+) cell, CFU-GM, WBC and BPC (P &lt; 0.001).	Cadmium	376-378	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
14642174-4	2003	RESULTS: There was a significant increase in plasma levels of IL-8 and both adhesion molecules [IL-8 (247.4 +/- 84.2) microg/L (P &lt; 0.01); sICAM-1 (530.3 +/- 286.1) microg/L (P = 0.002 7); sVCAM-1 (575.3 +/- 350.4) microg/L (P = 0.001 3)] during the mobilization process; furthermore, IL-8 and sVCAM-1 concentration in the patient"s plasma was paralleled to the numbers of CD(34)(+) cell, CFU-GM, WBC and BPC (P &lt; 0.001).	S-(4-bromophenyl)cysteine sulfoxide	408-411	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
12883201-11	2003	The cold/rewarming-induced IL-8 production was reduced to approximately 50% by introducing an antisense oligonucleotide for the p65 subunit of NF-kappaB and by treatment with N-acetyl-leucinyl-leucinyl-norleucinal and pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	218-245	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
14506934-2	2003	This study investigated the possible effects of IL-1alpha, tumor necrosis factor-alpha (TNF-alpha), protein kinase C (PKC) activators (TPA), and db-cyclic adenosine monophosphate (cAMP) on IL-8 and GRO-alpha production by immortalized GC1a and granulosa-lutein cells.	db-cyclic adenosine monophosphate	145-178	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
12821113-6	2003	In addition, DFX significantly increased the production of IL-6, IL-8, and TNF-alpha in HMC-1 (P&lt;0.05).	Deferoxamine	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
12925148-3	2003	Effects of PGs on the production of other cytokines such as interleukin (IL)-6 and IL-8 have been controversial.	Prostaglandins	11-14	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
12925148-9	2003	Reb suppressed PGE1 -, but not 15d-PGJ2-, induced increase of IL-6 and IL-8 production.	Alprostadil	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
12818968-0	2003	Dobutamine modulates lipopolysaccharide-induced macrophage inflammatory protein-1alpha and interleukin-8 production in human monocytes.	Dobutamine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
12818968-3	2003	We conducted this study to investigate the effect of dobutamine on lipopolysaccharide (LPS)-induced MIP-1alpha and IL-8 production by human monocytic THP-1 cells.	Dobutamine	53-63	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
12840601-8	2003	RESULTS: Urinary IL-8 during relapse was significantly increased when compared with that of during remission or controls (13,996 +/- 2,811 vs. 2,941 +/- 373, 5,331 +/- 640 ng/mg.cr) (p &lt; 0.05).	Chromium	57-59	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
12818968-6	2003	Dobutamine significantly inhibited LPS-induced MIP-1alpha and IL-8 production by THP-1 cells in a dose-dependent manner.	Dobutamine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
12818968-7	2003	Salbutamol had a similar suppressive effect on LPS-stimulated MIP-1alpha and IL-8 production.	Albuterol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
12818968-10	2003	These findings suggest that dobutamine may inhibit macrophage chemotaxis, as well as MIP-1alpha and IL-8 production by monocytes.	Dobutamine	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
14506934-5	2003	RESULTS: Treatment of granulosa-lutein cells with of IL-1alpha (1 nM), TNF-alpha (1 nM), TPA (1 nM) and db-cAMP (100 microM) produced higher levels of IL-8 than untreated cells by 8 hr (2274.7 +/- 146.3, 1489.8 +/- 190.1, 1452.9 +/- 152.7, 1313.6 +/- 48.4 pg/mL, respectively; control = 457.7 +/- 38.2 pg/mL; P &lt; 0.001).	db-cAMP	104-111	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
12818968-13	2003	Our study suggests that dobutamine may inhibit macrophage chemotaxis, as well as lipopolysaccharide-induced MIP-1alpha and IL-8 production by human monocytes.	Dobutamine	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	Toluene	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
12811578-0	2003	Comparative effects of polyphenols from green tea (EGCG) and soybean (genistein) on VEGF and IL-8 release from normal human keratinocytes stimulated with the proinflammatory cytokine TNFalpha.	epigallocatechin gallate	51-55	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
12811578-3	2003	We therefore evaluated the effects of green tea, its major component epigallocatechin-3-gallate (EGCG) and an isoflavone derived from soybean (genistein) on the release of VEGF and IL-8 by activated normal human keratinocytes (NHK).	epigallocatechin gallate	69-95	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	Toluene	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12811578-3	2003	We therefore evaluated the effects of green tea, its major component epigallocatechin-3-gallate (EGCG) and an isoflavone derived from soybean (genistein) on the release of VEGF and IL-8 by activated normal human keratinocytes (NHK).	epigallocatechin gallate	97-101	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	Toluene	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12811578-3	2003	We therefore evaluated the effects of green tea, its major component epigallocatechin-3-gallate (EGCG) and an isoflavone derived from soybean (genistein) on the release of VEGF and IL-8 by activated normal human keratinocytes (NHK).	Isoflavones	110-120	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
12811578-3	2003	We therefore evaluated the effects of green tea, its major component epigallocatechin-3-gallate (EGCG) and an isoflavone derived from soybean (genistein) on the release of VEGF and IL-8 by activated normal human keratinocytes (NHK).	Genistein	143-152	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	Xylenes	81-87	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
12811578-8	2003	Green tea and EGCG were also potent inhibitors of IL-8 release by TNFalpha-stimulated NHK, whereas genistein exerted only minor effects.	epigallocatechin gallate	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	Xylenes	81-87	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12811578-9	2003	These results underline the divergent pathways involved in the downregulation of VEGF and IL-8 by polyphenols in activated keratinocytes.	Polyphenols	98-109	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	Xylenes	81-87	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	pseudocumene	89-105	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
12672669-0	2003	Progesterone represses interleukin-8 and cyclo-oxygenase-2 in human lower segment fibroblast cells and amnion epithelial cells.	Progesterone	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	23-36
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	pseudocumene	89-105	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	pseudocumene	89-105	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	phenylcyclohexane	107-124	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	phenylcyclohexane	107-124	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	phenylcyclohexane	107-124	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	2,6-dimethylnaphthalene	129-148	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	2,6-dimethylnaphthalene	129-148	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	2,6-dimethylnaphthalene	129-148	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	phenylcyclohexane	288-305	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	phenylcyclohexane	288-305	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	phenylcyclohexane	288-305	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	2,6-dimethylnaphthalene	310-329	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	2,6-dimethylnaphthalene	310-329	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12871843-13	2003	Furthermore, GM-CSF, RANTES and to a lesser extent IL-8 release from HASMC treated with TNFalpha and IL-1beta was inhibited dosedependently by SP600125.	hasmc	69-74	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
12851741-6	2003	There was a dose-related differential response in IL-8 release at 24 h. Toluene, xylene, trimethylbenzene, cyclohexylbenzene and dimethylnaphthalene significantly decreased IL-8 release at the respective HNTDs, while IL-8 release did not continue to decrease, or significantly increased (cyclohexylbenzene and dimethylnaphthalene), at the LD(50).	2,6-dimethylnaphthalene	310-329	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12871843-13	2003	Furthermore, GM-CSF, RANTES and to a lesser extent IL-8 release from HASMC treated with TNFalpha and IL-1beta was inhibited dosedependently by SP600125.	pyrazolanthrone	143-151	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
12851741-7	2003	IL-8 significantly increased with both doses of methylnaphthalene and naphthalene.	1-methylnaphthalene	48-65	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12851741-7	2003	IL-8 significantly increased with both doses of methylnaphthalene and naphthalene.	naphthalene	54-65	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12901850-2	2003	We have observed that nitrosoglutathione or another NO-generating compound spermine NONOate caused significant accumulation of IL-8 mRNA.	S-Nitrosoglutathione	22-40	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
12839933-9	2003	Treatment with the proteasome inhibitor, MG-132, blocked BBS-stimulated NF kappa B DNA binding, and IL-8 and VEGF expression and secretion.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	41-47	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
12901850-5	2003	Furthermore, we have shown that IL-8 induction was not inhibited by catalase and the iron chelator deferoxamine, indicating that the inhibitory actions of DMSO and DMTU are not related to scavenging of reactive oxygen species produced from hydrogen peroxide in the iron-catalyzed reactions.	Dimethyl Sulfoxide	155-159	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
12791215-2	2003	Histamine, released from the conjunctival mast cells, might stimulate the synthesis of proinflammatory molecules such as IL-6 and IL-8 by the epithelial cells through the receptors that couple to inositol phosphate generation and, therefore, amplify the allergic response.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
12901850-2	2003	We have observed that nitrosoglutathione or another NO-generating compound spermine NONOate caused significant accumulation of IL-8 mRNA.	spermine nitric oxide complex	75-91	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
12791215-2	2003	Histamine, released from the conjunctival mast cells, might stimulate the synthesis of proinflammatory molecules such as IL-6 and IL-8 by the epithelial cells through the receptors that couple to inositol phosphate generation and, therefore, amplify the allergic response.	Inositol Phosphates	196-214	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
12901850-5	2003	Furthermore, we have shown that IL-8 induction was not inhibited by catalase and the iron chelator deferoxamine, indicating that the inhibitory actions of DMSO and DMTU are not related to scavenging of reactive oxygen species produced from hydrogen peroxide in the iron-catalyzed reactions.	1,3-dimethyl-4-thiouracil	164-168	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
12901850-3	2003	Pretreatment of cells with pyrrolidine dithiocarbamate or with antioxidants, which scavenge hydroxyl radical, dimethyl sulfoxide (DMSO), or dimetylthiourea (DMTU) completely abrogated NO-dependent induction of IL-8 gene expression.	pyrrolidine dithiocarbamic acid	27-54	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
12901850-7	2003	Therefore, it seems likely that in U937 cells, hydroxyl radicals or species with reactivity similar to hydroxyl radicals contribute to NO-mediated IL-8 gene induction.	Hydroxyl Radical	47-64	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
12901850-7	2003	Therefore, it seems likely that in U937 cells, hydroxyl radicals or species with reactivity similar to hydroxyl radicals contribute to NO-mediated IL-8 gene induction.	Hydroxyl Radical	103-120	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
12901850-4	2003	The transcriptional activation of IL-8 gene was not affected by sodium formate or sodium salicylate, suggesting that suppression of the IL-8 gene induction is specific to the class of hydroxyl radical scavenger used.	Hydroxyl Radical	184-200	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
12901850-4	2003	The transcriptional activation of IL-8 gene was not affected by sodium formate or sodium salicylate, suggesting that suppression of the IL-8 gene induction is specific to the class of hydroxyl radical scavenger used.	Hydroxyl Radical	184-200	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
12882457-5	2003	IL-6 and IL-8 production was lower in COPD patients taking inhaled steroids.	Steroids	67-75	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
12882461-9	2003	These data suggest that regular use of salbutamol can augment airway CXCL8/interleukin-8 responses to allergen challenge and that this CXCL8/interleukin-8 could contribute to the airway inflammatory response.	Albuterol	39-49	C-X-C motif chemokine ligand 8	Homo sapiens	69-74
12882461-0	2003	Regular salbutamol use increases CXCL8 responses in asthma: relationship to the eosinophil response.	Albuterol	8-18	C-X-C motif chemokine ligand 8	Homo sapiens	33-38
12882461-9	2003	These data suggest that regular use of salbutamol can augment airway CXCL8/interleukin-8 responses to allergen challenge and that this CXCL8/interleukin-8 could contribute to the airway inflammatory response.	Albuterol	39-49	C-X-C motif chemokine ligand 8	Homo sapiens	75-88
12882461-9	2003	These data suggest that regular use of salbutamol can augment airway CXCL8/interleukin-8 responses to allergen challenge and that this CXCL8/interleukin-8 could contribute to the airway inflammatory response.	Albuterol	39-49	C-X-C motif chemokine ligand 8	Homo sapiens	141-154
12899430-2	2003	An expert witness for the defence alleged that a deficient volume of blood in the tube sent for analysis meant an excess amount of sodium fluoride (NaF) preservative, which would increase the concentration of ethanol, determined by headspace gas chromatography (HS-GC), owing to a salting-out effect.	Sodium Fluoride	131-146	C-X-C motif chemokine ligand 8	Homo sapiens	148-151
14979118-0	2003	[Determination of interleukin-8 in induced sputum of workers exposed to low concentrations of asbestos].	Asbestos	94-102	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
12899430-2	2003	An expert witness for the defence alleged that a deficient volume of blood in the tube sent for analysis meant an excess amount of sodium fluoride (NaF) preservative, which would increase the concentration of ethanol, determined by headspace gas chromatography (HS-GC), owing to a salting-out effect.	Ethanol	209-216	C-X-C motif chemokine ligand 8	Homo sapiens	148-151
12899430-2	2003	An expert witness for the defence alleged that a deficient volume of blood in the tube sent for analysis meant an excess amount of sodium fluoride (NaF) preservative, which would increase the concentration of ethanol, determined by headspace gas chromatography (HS-GC), owing to a salting-out effect.	hs-gc	262-267	C-X-C motif chemokine ligand 8	Homo sapiens	148-151
12899430-8	2003	Our experiments showed that a deficient volume of blood and excess NaF actually lowered the concentration of ethanol by 2-3% compared with heparinised blood.	Ethanol	109-116	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
12794155-4	2003	The tyrosine kinase inhibitor herbimycin blocked Ad19-induced IL-8 expression.	herbimycin	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
14518569-8	2003	15d-PGJ2 induced, by itself, the expression of interleukin-8, a potent proinflammatory chemokine, in HUVEC.	15-deoxy-delta(12,14)-prostaglandin J2	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	47-60
12837459-10	2003	A reduction in urinary IL-8 levels after treatment with bacille Calmette-Guerin or mitomycin C may reflect a decrease in bladder cancer cells and/or in other cells that produce IL-8.	Mitomycin	83-94	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
12837459-10	2003	A reduction in urinary IL-8 levels after treatment with bacille Calmette-Guerin or mitomycin C may reflect a decrease in bladder cancer cells and/or in other cells that produce IL-8.	Mitomycin	83-94	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
12818188-7	2003	Moreover, human hepatic cathepsin L cleaved 77IL-8 between Arg(5) and Ser(6), which is the same cleavage site as the putative converting enzyme, resulting in 72IL-8 formation.	Arginine	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
12818188-7	2003	Moreover, human hepatic cathepsin L cleaved 77IL-8 between Arg(5) and Ser(6), which is the same cleavage site as the putative converting enzyme, resulting in 72IL-8 formation.	Serine	70-73	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
12794155-6	2003	Respective inhibitors of these kinases, PP2 and PD98059, also blocked Ad19-induced IL-8 mRNA and protein expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	48-55	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
12749935-2	2003	Based on the results of an in vitro transmigration system, human recombinant interleukin-8 (rhIL-8; 1.25 microg per mare and 5 microg per cow in 50 ml phosphate-buffered saline) was used to attract polymorphonuclear neutrophil granulocytes (PMNs) into the uteri.	Phosphate-Buffered Saline	151-176	C-X-C motif chemokine ligand 8	Homo sapiens	77-90
12842763-11	2003	These results indicate that methylprednisolone significantly reduces the production of IL-8 in an isolated CPB system.	Methylprednisolone	28-46	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
12600836-5	2003	Furthermore, the PKR inhibitor 2-aminopurine significantly blocked dsRNA-induced RANTES and IL-8 secretion, whereas the p38 mitogen-activated protein kinase inhibitor SB203580 suppressed dsRNA-induced IL-8, but not RANTES.	2-Aminopurine	31-44	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
12600836-5	2003	Furthermore, the PKR inhibitor 2-aminopurine significantly blocked dsRNA-induced RANTES and IL-8 secretion, whereas the p38 mitogen-activated protein kinase inhibitor SB203580 suppressed dsRNA-induced IL-8, but not RANTES.	SB 203580	167-175	C-X-C motif chemokine ligand 8	Homo sapiens	201-205
12809941-0	2003	Interleukin 8 response and oxidative stress in HepG2 cells treated with ethanol, acetaldehyde or lipopolysaccharide.	Ethanol	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
12797494-0	2003	Possible anti-inflammatory effect of salmeterol against interleukin-8 and neutrophil activation in asthma in vivo.	Salmeterol Xinafoate	37-47	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
12797494-3	2003	There is currently interest in the "neutrophil system" in asthma, and thus the aim of the present study was to investigate the effect of salmeterol on interleukin (IL)-8, neutrophils and myeloperoxidase (MPO) in persistent asthma.	Salmeterol Xinafoate	137-147	C-X-C motif chemokine ligand 8	Homo sapiens	151-169
12797494-10	2003	In contrast, introducing salmeterol significantly reduced IL-8 and MPO levels, but did not affect BALF neutrophil numbers.	Salmeterol Xinafoate	25-35	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
12809941-0	2003	Interleukin 8 response and oxidative stress in HepG2 cells treated with ethanol, acetaldehyde or lipopolysaccharide.	Acetaldehyde	81-93	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
12809941-1	2003	The aim of this work was to study the induction and secretion of interleukin 8 (IL-8) and some oxidative stress parameters after ethanol (EtOH), acetaldehyde (Ac) or lipopolysaccharide (LPS) treatment on HepG2 cells.	Ethanol	129-136	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
12809941-1	2003	The aim of this work was to study the induction and secretion of interleukin 8 (IL-8) and some oxidative stress parameters after ethanol (EtOH), acetaldehyde (Ac) or lipopolysaccharide (LPS) treatment on HepG2 cells.	Ethanol	129-136	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
12809941-1	2003	The aim of this work was to study the induction and secretion of interleukin 8 (IL-8) and some oxidative stress parameters after ethanol (EtOH), acetaldehyde (Ac) or lipopolysaccharide (LPS) treatment on HepG2 cells.	Ethanol	138-142	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
12875365-0	2003	Combined effect of hydrogen peroxide induced oxidative stress and IL-1 alpha on IL-8 production in CaCo-2 cells (a human colon carcinoma cell line) and normal intestinal epithelial cells.	Hydrogen Peroxide	19-36	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
12875365-2	2003	We examined the IL-8 response after brief exposure to hydrogen peroxide induced oxidative stress in CaCo-2 cells (a human colon carcinoma cell line) and in human intestinal epithelial cells.	Hydrogen Peroxide	54-71	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
12875365-4	2003	A transient up-regulation of IL-8 mRNA expression was observed after hydrogen peroxide treatment.	Hydrogen Peroxide	69-86	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
12875365-5	2003	Hydrogen peroxide induced oxidative stress was also observed to promote IL-8 secretion.	Hydrogen Peroxide	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
12809941-1	2003	The aim of this work was to study the induction and secretion of interleukin 8 (IL-8) and some oxidative stress parameters after ethanol (EtOH), acetaldehyde (Ac) or lipopolysaccharide (LPS) treatment on HepG2 cells.	Acetaldehyde	145-157	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
12875365-6	2003	Exposure to hydrogen peroxide, followed by IL-1alpha, enhanced IL-8 production over that achieved with IL-1alpha alone.	Hydrogen Peroxide	12-29	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
12809941-1	2003	The aim of this work was to study the induction and secretion of interleukin 8 (IL-8) and some oxidative stress parameters after ethanol (EtOH), acetaldehyde (Ac) or lipopolysaccharide (LPS) treatment on HepG2 cells.	Acetaldehyde	145-157	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
12875367-0	2003	Alveolar epithelial cell-macrophage interactions affect oxygen-stimulated interleukin-8 release.	Oxygen	56-62	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
12809941-1	2003	The aim of this work was to study the induction and secretion of interleukin 8 (IL-8) and some oxidative stress parameters after ethanol (EtOH), acetaldehyde (Ac) or lipopolysaccharide (LPS) treatment on HepG2 cells.	Acetaldehyde	159-161	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
12809941-1	2003	The aim of this work was to study the induction and secretion of interleukin 8 (IL-8) and some oxidative stress parameters after ethanol (EtOH), acetaldehyde (Ac) or lipopolysaccharide (LPS) treatment on HepG2 cells.	Acetaldehyde	159-161	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
12809941-15	2003	This observation suggests that in the in vivo liver, the mechanism of ethanol-induced IL-8 production requires ethanol metabolism, and hepatocytes do not require the interaction among different populations of liver cells to respond.	Ethanol	70-77	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
12781700-6	2003	However, this effect of BFA was less marked when neutrophils were treated with dexamethasone, interleukin-8 (IL-8), or dibutyryl cAMP (dbcAMP).	Brefeldin A	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	94-107
12781700-6	2003	However, this effect of BFA was less marked when neutrophils were treated with dexamethasone, interleukin-8 (IL-8), or dibutyryl cAMP (dbcAMP).	Brefeldin A	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
12809941-15	2003	This observation suggests that in the in vivo liver, the mechanism of ethanol-induced IL-8 production requires ethanol metabolism, and hepatocytes do not require the interaction among different populations of liver cells to respond.	Ethanol	111-118	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
12765200-0	2003	Suppression of IL-8 gene transcription by resveratrol in phorbol ester treated human monocytic cells.	Resveratrol	42-53	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
12765200-10	2003	Resveratrol could inhibit PMA-induced IL-8 production in U937 cells at protein and mRNA levels.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
12765200-10	2003	Resveratrol could inhibit PMA-induced IL-8 production in U937 cells at protein and mRNA levels.	Tetradecanoylphorbol Acetate	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
12765200-0	2003	Suppression of IL-8 gene transcription by resveratrol in phorbol ester treated human monocytic cells.	Phorbol Esters	57-70	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
12765200-11	2003	The suppression of IL-8 gene transcription by resveratrol was, at least partly, due to inhibition of AP-1 activation.	Resveratrol	46-57	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
12765200-2	2003	To observe the modulation of interleukin-8 (IL-8) production in human monocytic cells by resveratrol and explore its mechanism at the gene transcription level, U937 cells were stimulated with phorbol 12-myristate 13-acetate (PMA) for 24h.	Resveratrol	89-100	C-X-C motif chemokine ligand 8	Homo sapiens	29-42
12765200-2	2003	To observe the modulation of interleukin-8 (IL-8) production in human monocytic cells by resveratrol and explore its mechanism at the gene transcription level, U937 cells were stimulated with phorbol 12-myristate 13-acetate (PMA) for 24h.	Resveratrol	89-100	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
12765200-7	2003	0.01-100 nM PMA could significantly induce IL-8 production in U937 cells; 10 microM Dexamethasone and 10, 1, 0.1 microM resveratrol could inhibit PMA-induced IL-8 protein production and mRNA accumulation.	Tetradecanoylphorbol Acetate	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
12765200-7	2003	0.01-100 nM PMA could significantly induce IL-8 production in U937 cells; 10 microM Dexamethasone and 10, 1, 0.1 microM resveratrol could inhibit PMA-induced IL-8 protein production and mRNA accumulation.	Tetradecanoylphorbol Acetate	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
12765200-7	2003	0.01-100 nM PMA could significantly induce IL-8 production in U937 cells; 10 microM Dexamethasone and 10, 1, 0.1 microM resveratrol could inhibit PMA-induced IL-8 protein production and mRNA accumulation.	Dexamethasone	84-97	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
12765200-7	2003	0.01-100 nM PMA could significantly induce IL-8 production in U937 cells; 10 microM Dexamethasone and 10, 1, 0.1 microM resveratrol could inhibit PMA-induced IL-8 protein production and mRNA accumulation.	Resveratrol	120-131	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
12765200-7	2003	0.01-100 nM PMA could significantly induce IL-8 production in U937 cells; 10 microM Dexamethasone and 10, 1, 0.1 microM resveratrol could inhibit PMA-induced IL-8 protein production and mRNA accumulation.	Resveratrol	120-131	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
12765200-7	2003	0.01-100 nM PMA could significantly induce IL-8 production in U937 cells; 10 microM Dexamethasone and 10, 1, 0.1 microM resveratrol could inhibit PMA-induced IL-8 protein production and mRNA accumulation.	Tetradecanoylphorbol Acetate	146-149	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
12765200-7	2003	0.01-100 nM PMA could significantly induce IL-8 production in U937 cells; 10 microM Dexamethasone and 10, 1, 0.1 microM resveratrol could inhibit PMA-induced IL-8 protein production and mRNA accumulation.	Tetradecanoylphorbol Acetate	146-149	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
12759450-3	2003	Transient transfection with the constitutively active catalytic subunit of PKC delta (PKC delta-CAT), and treatment with bryostatin 1, an activator of PKC delta, each increased transcription from the IL-8 promoter, whereas overexpression of PKC epsilon had minor effects.	bryostatin 1	121-133	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
12759450-4	2003	Expression of a dominant negative PKC delta mutant (PKC delta-KR) or pretreatment of cells with rottlerin, a chemical PKC delta inhibitor, attenuated TNF-alpha- and phorbol ester-induced transcription from the IL-8 promoter.	rottlerin	96-105	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
12759450-4	2003	Expression of a dominant negative PKC delta mutant (PKC delta-KR) or pretreatment of cells with rottlerin, a chemical PKC delta inhibitor, attenuated TNF-alpha- and phorbol ester-induced transcription from the IL-8 promoter.	Phorbol Esters	165-178	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
12759450-5	2003	Bryostatin 1 treatment increased IL-8 protein abundance in primary airway epithelial cells.	bryostatin 1	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
12856595-6	2003	The results showed that NF-kappa B p65 antisense oligonucleotides resulted in down-regulation of NF-kappa B p65 expression, blocked the expression of IL-1 beta mRNA and IL-8 mRNA, and strikingly reduced the production of IL-1 beta and IL-8, and these effects were greater than those of dexamethasone in cultured LPMC from patients with UC(P &lt; 0.05).	Dexamethasone	286-299	C-X-C motif chemokine ligand 8	Homo sapiens	235-239
12856595-6	2003	The results showed that NF-kappa B p65 antisense oligonucleotides resulted in down-regulation of NF-kappa B p65 expression, blocked the expression of IL-1 beta mRNA and IL-8 mRNA, and strikingly reduced the production of IL-1 beta and IL-8, and these effects were greater than those of dexamethasone in cultured LPMC from patients with UC(P &lt; 0.05).	Oligonucleotides	49-65	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
12856595-6	2003	The results showed that NF-kappa B p65 antisense oligonucleotides resulted in down-regulation of NF-kappa B p65 expression, blocked the expression of IL-1 beta mRNA and IL-8 mRNA, and strikingly reduced the production of IL-1 beta and IL-8, and these effects were greater than those of dexamethasone in cultured LPMC from patients with UC(P &lt; 0.05).	Oligonucleotides	49-65	C-X-C motif chemokine ligand 8	Homo sapiens	235-239
12857601-7	2003	The p38 mitogen-activated protein kinase inhibitor SB 203580 inhibits the IL-8 mRNA expression and the release of protein from neutrophils.	SB 203580	51-60	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
12857601-8	2003	The release of IL-8 from SAA-stimulated neutrophils is strongly suppressed by the addition of N-acetyl-l-cysteine, alpha-mercaptoethanol, glutathione, and dexamethasone.	Acetylcysteine	94-113	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
12857601-8	2003	The release of IL-8 from SAA-stimulated neutrophils is strongly suppressed by the addition of N-acetyl-l-cysteine, alpha-mercaptoethanol, glutathione, and dexamethasone.	alpha-mercaptoethanol	115-136	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
12857601-8	2003	The release of IL-8 from SAA-stimulated neutrophils is strongly suppressed by the addition of N-acetyl-l-cysteine, alpha-mercaptoethanol, glutathione, and dexamethasone.	Glutathione	138-149	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
12857601-8	2003	The release of IL-8 from SAA-stimulated neutrophils is strongly suppressed by the addition of N-acetyl-l-cysteine, alpha-mercaptoethanol, glutathione, and dexamethasone.	Dexamethasone	155-168	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
12856595-6	2003	The results showed that NF-kappa B p65 antisense oligonucleotides resulted in down-regulation of NF-kappa B p65 expression, blocked the expression of IL-1 beta mRNA and IL-8 mRNA, and strikingly reduced the production of IL-1 beta and IL-8, and these effects were greater than those of dexamethasone in cultured LPMC from patients with UC(P &lt; 0.05).	lpmc	312-316	C-X-C motif chemokine ligand 8	Homo sapiens	235-239
12637525-9	2003	Our data demonstrate that the cyclic stretch of HASMC causes the increased production of IL-8 by activating the AP-1 and C/EBP transcription factors through the activation of ERK1/2 and p38 kinase signaling pathways.	hasmc	48-53	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
12793907-3	2003	We recently reported that plasma IL-8 is increased in obese subjects with normal glucose tolerance (NGT).	Glucose	81-88	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
12793907-12	2003	CONCLUSION: Plasma IL-8 concentrations after glucose load are increased in obese IGT subjects in comparison to normoglycemic weight-matched individuals.	Glucose	45-52	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
12793907-13	2003	Increase in plasma IL-8 might be both insulin-mediated (during clamp) and glucose-mediated (during OGTT).	Glucose	74-81	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
12639714-0	2003	Interleukin-8 production induced by the endozepine triakontatetraneuropeptide in human neutrophils: role of calcium and pharmacological investigation of signal transduction pathways.	Calcium	108-115	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
12754109-8	2003	Relative and competitive RT-PCR analysis verified downregulation of TNFalpha-mediated expression of CD40L and IL-8 by Dexa and Dexa-Ab(hEsel), respectively.	Dexamethasone	118-122	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
12754109-8	2003	Relative and competitive RT-PCR analysis verified downregulation of TNFalpha-mediated expression of CD40L and IL-8 by Dexa and Dexa-Ab(hEsel), respectively.	dexa-ab	127-134	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
12770938-8	2003	5 When EC were preincubated with the specific Rho kinase (ROCK) inhibitor Y-27632, we observed a reduction in PMN adherence in response to thrombin, as well as a decrease in thrombin-stimulated IL-8 production.	Y 27632	74-81	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
12727366-6	2003	Prolonged incubation of both serum-opsonized and -unopsonized zymosan particles with HUVEC induced increased secretion of the proinflammatory cytokines IL-6 and IL-8 to the cell culture supernatants, but had no effect on production of oxygen radicals.	Zymosan	62-69	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
12736519-3	2003	DFX significantly increased interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-alpha production compared with the control in a time-dependent manner (p&lt;0.05), but did not affect IL-1alpha production and mRNA expression.	Deferoxamine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
12639714-2	2003	Because interleukin-8 (IL-8) production is Ca(2+) dependent and can be induced by chemotactic stimuli, we have investigated the ability of TTN to induce IL-8 production in PMNs, as well as the signal transduction mechanisms involved.	Tartronic acid	139-142	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
12736467-0	2003	Inhibitory effect of TNF-alpha and IL-8 secretion by pimarane-type diterpenoids from Acanthopanax koreanum.	pimarane	53-61	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
12639714-3	2003	Our results show that TTN increases IL-8 release and IL-8 mRNA expression in a concentration- and time-dependent fashion, and these effects are prevented by the Ca(2+) chelator BAPTA-AM.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	177-185	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
12736467-0	2003	Inhibitory effect of TNF-alpha and IL-8 secretion by pimarane-type diterpenoids from Acanthopanax koreanum.	Diterpenes	67-79	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
12639714-3	2003	Our results show that TTN increases IL-8 release and IL-8 mRNA expression in a concentration- and time-dependent fashion, and these effects are prevented by the Ca(2+) chelator BAPTA-AM.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	177-185	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
12736467-2	2003	Acanthoic acid was isolated in high yields and showed potent inhibitory activity on the IL-8 secretion of the TNF-alpha-stimulated human colon adenocarcinoma cell line HT-29 and on the TNF-alpha secretion of the trypsin-stimulated human leukemic mast cell line HMC-1.	acanthoic acid	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
12639714-4	2003	TTN-induced [Ca(2+)](i) changes and IL-8 mRNA expression are sensitive to pertussis toxin, to the phospholipase C (PLC) inhibitor U73122 (but not to its inactive analogue U73343) and to the protein kinase C (PKC) inhibitor calphostin C.	Tartronic acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
12639714-4	2003	TTN-induced [Ca(2+)](i) changes and IL-8 mRNA expression are sensitive to pertussis toxin, to the phospholipase C (PLC) inhibitor U73122 (but not to its inactive analogue U73343) and to the protein kinase C (PKC) inhibitor calphostin C.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	130-136	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
12639714-5	2003	It is therefore suggested that TTN-induced IL-8 production in human PMNs results from a G protein-operated, PLC-activated [Ca(2+)](i) rise, and PKC contributes to this effect.	Tartronic acid	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
12849706-0	2003	Glutamine decreases lipopolysaccharide-induced IL-8 production in Caco-2 cells through a non-NF-kappaB p50 mechanism.	Glutamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
12849706-10	2003	The addition of Gln (0.5 or 5.0mM) decreased IL-8 peptide and mRNA expression.	Glutamine	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
12849706-13	2003	These results indicate that the lack of glutamine increases IL-8 production by Caco-2 cells after LPS stimulation.	Glutamine	40-49	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
12849706-8	2003	The largest amount of IL-8 was secreted by cells in the presence of MS with no Gln in the medium after exposure to LPS.	Glutamine	79-82	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
12849706-14	2003	However, the glutamine-mediated decrease in LPS-stimulated IL-8 production is not associated with NF-kappaB p50 nuclear binding.	Glutamine	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
12880368-1	2003	The stimulatory effects of sodium fluoride (NaF) on bone formation have been explained solely by its activation of osteoblasts.	Sodium Fluoride	27-42	C-X-C motif chemokine ligand 8	Homo sapiens	44-47
12697421-5	2003	The induced IL-8 and MCP-1 proteins were almost completely supporessed by U0126, a specific mitogen-activated protein kinase kinase (MEK) inhibitor, or by SB203580, a selective p38 inhibitor.	U 0126	74-79	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
12697421-5	2003	The induced IL-8 and MCP-1 proteins were almost completely supporessed by U0126, a specific mitogen-activated protein kinase kinase (MEK) inhibitor, or by SB203580, a selective p38 inhibitor.	SB 203580	155-163	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
12697421-7	2003	Induction of IL-8 and MCP-1 was abrogated by Ro318220, an inhibitor of PKC, as well as by genistein or herbimycin A, inhibitors of PTK.	Ro 31-8220	45-53	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
12697421-7	2003	Induction of IL-8 and MCP-1 was abrogated by Ro318220, an inhibitor of PKC, as well as by genistein or herbimycin A, inhibitors of PTK.	Genistein	90-99	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
12697421-7	2003	Induction of IL-8 and MCP-1 was abrogated by Ro318220, an inhibitor of PKC, as well as by genistein or herbimycin A, inhibitors of PTK.	herbimycin	103-115	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
12717385-11	2003	LPS-induced IL-8 secretion is completely inhibited by the IkappaB super repressor (Ad5IkappaB) and partially inhibited by a specific JNK inhibitor, SP600125.	pyrazolanthrone	148-156	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
12880368-5	2003	NaF at subtoxic concentrations (&lt;0.5 mM) significantly up-regulated activities of several intracellular enzymes (lactate dehydrogenase, beta-glucuronidase, acid phosphatase), cellular reduction of nitroblue tetrazolium, and nitric oxide (NO) production; which are all accepted as general differentiation markers.	Nitroblue Tetrazolium	200-221	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
12880368-5	2003	NaF at subtoxic concentrations (&lt;0.5 mM) significantly up-regulated activities of several intracellular enzymes (lactate dehydrogenase, beta-glucuronidase, acid phosphatase), cellular reduction of nitroblue tetrazolium, and nitric oxide (NO) production; which are all accepted as general differentiation markers.	Nitric Oxide	227-239	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
12533503-9	2003	The increase in mRNA (fold difference from preexercise) was attenuated in CHO (15.9-fold) compared with Pla (35.2-fold) for IL-6 (P = 0.071) and IL-8 (CHO, 7.8-fold; Pla, 23.3-fold; P = 0.063).	CAV protocol	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
12533503-9	2003	The increase in mRNA (fold difference from preexercise) was attenuated in CHO (15.9-fold) compared with Pla (35.2-fold) for IL-6 (P = 0.071) and IL-8 (CHO, 7.8-fold; Pla, 23.3-fold; P = 0.063).	CAV protocol	151-154	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
12533503-10	2003	CHO compared with Pla beverage ingestion attenuates the increase in plasma IL-6, IL-10, and IL-1ra and gene expression for IL-6 and IL-8 in athletes running 3 h at 70% Vo(2 max) despite no differences in muscle glycogen content.	CAV protocol	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
12713595-8	2003	DP treatment also blocked VCAM-1 induction in human umbilical vein endothelium and blocked induction of a host of NF-kB activated genes in HDMEC including ICAM-1, IL-8, and tissue factor.	2,2'-Dipyridyl	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
12695526-9	2003	In addition, we show that AJA inhibits interleukin-8 promoter activity in a PPARgamma-dependent manner, suggesting a link between the anti-inflammatory action of AJA and the activation of PPARgamma.	lenabasum	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
12871375-0	2003	The promoting effect of epinephrine on lipopolysaccharide-induced interleukin-8 production in whole blood may be mediated by thromboxane A2.	Epinephrine	24-35	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
12871375-0	2003	The promoting effect of epinephrine on lipopolysaccharide-induced interleukin-8 production in whole blood may be mediated by thromboxane A2.	Thromboxane A2	125-139	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
12871375-1	2003	Epinephrine is known to enhance lipopolysaccharide (LPS)-induced interleukin (IL)-8 secretion in a platelet dependent manner.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	65-83
12871375-3	2003	ASA ingestion significantly (global P &lt; 0.05) reduced the enhancing effect of epinephrine on LPS-induced IL-8 release by 15-28%.	Aspirin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
12871375-3	2003	ASA ingestion significantly (global P &lt; 0.05) reduced the enhancing effect of epinephrine on LPS-induced IL-8 release by 15-28%.	Epinephrine	81-92	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
12871375-5	2003	U46619 mimicked the epinephrine effect: 20 ng mL(-1) U46619 enhanced LPS-induced IL-8 release by 39% (P &lt; 0.05).	Epinephrine	20-31	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
12871375-6	2003	Furthermore, preincubation of whole blood with 75 micro mol L-1 or 150 micromol L(-1) SQ29548, a TxA2 receptor antagonist, completely blocked epinephrine"s promoting effect on LPS-induced IL-8 release.	Epinephrine	142-153	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
12695526-9	2003	In addition, we show that AJA inhibits interleukin-8 promoter activity in a PPARgamma-dependent manner, suggesting a link between the anti-inflammatory action of AJA and the activation of PPARgamma.	lenabasum	162-165	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
12753408-0	2003	Regulation of 1-alpha, 25-dihydroxyvitamin D3 on interleukin-6 and interleukin-8 induced by sulfur mustard (HD) on human skin cells.	Calcitriol	14-45	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
12753408-0	2003	Regulation of 1-alpha, 25-dihydroxyvitamin D3 on interleukin-6 and interleukin-8 induced by sulfur mustard (HD) on human skin cells.	Mustard Gas	92-106	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
12456400-6	2003	We also observed that the expression of myc-LXA(4) conferred enhanced downregulation of IL-8 expression in response to LXA(4) analog and that blockade of the CysLT1 receptor by montelukast did not prevent this response to LXA(4) analog.	N-(1H-benzimidazol-2-ylmethyl)-2-methoxyacetamide	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
12938820-15	2003	Mesothelial cells showed a twofold increase in interleukin (IL)-6 and IL-8 production after exposure to 3-DG.	3-deoxyglucosone	104-108	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
12938820-18	2003	Upon short exposure to a single GDP, MCs react with enhanced cytotoxic damage and a proinflammatory response, evidenced by increased VCAM-1 expression and elevated production of IL-6 and IL-8.	Guanosine Diphosphate	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
12938820-18	2003	Upon short exposure to a single GDP, MCs react with enhanced cytotoxic damage and a proinflammatory response, evidenced by increased VCAM-1 expression and elevated production of IL-6 and IL-8.	mcs	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
12706459-2	2003	In the present study, we determined that Caco-2 cells express the kappa-opioid receptor and its activation by trans-(+/-)-3,4-dichloro-N-methyl-N[2-(1-pyrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate (U-50488) leads to decreased interleukin-8 secretion in the presence of interleukin-1beta.	trans-(+/-)-3,4-dichloro-n-methyl-n[2-(1-pyrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate	110-207	C-X-C motif chemokine ligand 8	Homo sapiens	237-250
12456400-6	2003	We also observed that the expression of myc-LXA(4) conferred enhanced downregulation of IL-8 expression in response to LXA(4) analog and that blockade of the CysLT1 receptor by montelukast did not prevent this response to LXA(4) analog.	N-(1H-benzimidazol-2-ylmethyl)-2-methoxyacetamide	119-122	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
12495941-4	2003	Pretreatment with the protein tyrosine kinase-specific inhibitors genistein and herbimycin A effectively blocked LPS-induced NF-kappaB activation as well as IL-8 gene expression in human peripheral blood monocytes.	Genistein	66-75	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
12495941-7	2003	These findings provide evidence that LPS-induced NF-kappaB activation and IL-8 gene expression use a signaling pathway requiring protein tyrosine kinase and that such regulation may occur through tyrosine phosphorylation of TLR4.	Tyrosine	137-145	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
12711624-7	2003	Release of IL-8 was triggered by UDP, ATP, alpha,beta-meATP and BzATP, but not by UTP or ADP.	Uridine Diphosphate	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
12653788-7	2003	The correlation analysis revealed a significant correlation of IL-6 and/or IL-8 to age, total fructose, immunoglobulin G (IgG) concentration and leucocyte count.	Fructose	94-102	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
12654635-0	2003	Binding of interleukin-8 to heparan sulfate and chondroitin sulfate in lung tissue.	Heparitin Sulfate	28-43	C-X-C motif chemokine ligand 8	Homo sapiens	11-24
12654635-0	2003	Binding of interleukin-8 to heparan sulfate and chondroitin sulfate in lung tissue.	Chondroitin Sulfates	48-67	C-X-C motif chemokine ligand 8	Homo sapiens	11-24
12654635-5	2003	Confocal microscopy demonstrated IL-8 binding to specific anatomic locations such as cell surfaces and extracellular matrix that were enriched with heparan sulfate and chondroitin sulfate.	Heparitin Sulfate	148-163	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
12654635-5	2003	Confocal microscopy demonstrated IL-8 binding to specific anatomic locations such as cell surfaces and extracellular matrix that were enriched with heparan sulfate and chondroitin sulfate.	Chondroitin Sulfates	168-187	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
12654635-6	2003	Removal of heparan sulfate or chondroitin sulfate from lung tissue significantly decreased the binding of 125I-IL-8.	Heparitin Sulfate	11-26	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
12654635-6	2003	Removal of heparan sulfate or chondroitin sulfate from lung tissue significantly decreased the binding of 125I-IL-8.	Chondroitin Sulfates	30-49	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
12654635-9	2003	These findings suggest that IL-8-glycosaminoglycan interactions determine the location where IL-8 binds in lung tissue and provides a site for the dimerization of IL-8, which increases the local concentration of IL-8 in the lungs.	Glycosaminoglycans	33-50	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
12654635-9	2003	These findings suggest that IL-8-glycosaminoglycan interactions determine the location where IL-8 binds in lung tissue and provides a site for the dimerization of IL-8, which increases the local concentration of IL-8 in the lungs.	Glycosaminoglycans	33-50	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
12654635-9	2003	These findings suggest that IL-8-glycosaminoglycan interactions determine the location where IL-8 binds in lung tissue and provides a site for the dimerization of IL-8, which increases the local concentration of IL-8 in the lungs.	Glycosaminoglycans	33-50	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
12654635-9	2003	These findings suggest that IL-8-glycosaminoglycan interactions determine the location where IL-8 binds in lung tissue and provides a site for the dimerization of IL-8, which increases the local concentration of IL-8 in the lungs.	Glycosaminoglycans	33-50	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
12711624-7	2003	Release of IL-8 was triggered by UDP, ATP, alpha,beta-meATP and BzATP, but not by UTP or ADP.	Adenosine Triphosphate	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
12711624-7	2003	Release of IL-8 was triggered by UDP, ATP, alpha,beta-meATP and BzATP, but not by UTP or ADP.	alpha,beta-methyleneadenosine 5'-triphosphate	43-59	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
12711624-7	2003	Release of IL-8 was triggered by UDP, ATP, alpha,beta-meATP and BzATP, but not by UTP or ADP.	BzATP	64-69	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
12711624-10	2003	Release of IL-8 stimulated by BzATP was fully blocked by the P2X(7) blocker KN-62, while release triggered by ATP was only partially inhibited.	BzATP	30-35	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
12711624-10	2003	Release of IL-8 stimulated by BzATP was fully blocked by the P2X(7) blocker KN-62, while release triggered by ATP was only partially inhibited.	Adenosine Triphosphate	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
12711624-11	2003	IL-8 secretion due to UDP was fully insensitive to KN-62 inhibition.	Uridine Diphosphate	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12667212-8	2003	Evaluation of IL-8 and MCP-1 RNA messages by reverse transcription-polymerase chain reaction (RT-PCR) revealed that the inhibitory effect of SB 203580 was associated with a reduction in this parameter.	SB 203580	141-150	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
12684317-7	2003	Pretreatment of sputum or neutrophils with either an anti-IL-8 antibody or the LTB(4) antagonist, SB 201146, led to a concentration-dependent inhibition of sputum-induced neutrophil chemotaxis, with a maximum suppression (mean +/- SEM) of 29.2 +/- 4.9% (p &lt; 0.001) from baseline by 100 ng/mL of anti-IL-8 antibody, and 45.6 +/- 7% (p &lt; 0.02) by 10 micro mol/L of SB 201146.	SB 201146	98-107	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
12684317-7	2003	Pretreatment of sputum or neutrophils with either an anti-IL-8 antibody or the LTB(4) antagonist, SB 201146, led to a concentration-dependent inhibition of sputum-induced neutrophil chemotaxis, with a maximum suppression (mean +/- SEM) of 29.2 +/- 4.9% (p &lt; 0.001) from baseline by 100 ng/mL of anti-IL-8 antibody, and 45.6 +/- 7% (p &lt; 0.02) by 10 micro mol/L of SB 201146.	SB 201146	98-107	C-X-C motif chemokine ligand 8	Homo sapiens	303-307
12684317-7	2003	Pretreatment of sputum or neutrophils with either an anti-IL-8 antibody or the LTB(4) antagonist, SB 201146, led to a concentration-dependent inhibition of sputum-induced neutrophil chemotaxis, with a maximum suppression (mean +/- SEM) of 29.2 +/- 4.9% (p &lt; 0.001) from baseline by 100 ng/mL of anti-IL-8 antibody, and 45.6 +/- 7% (p &lt; 0.02) by 10 micro mol/L of SB 201146.	SB 201146	369-378	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
12676602-7	2003	Cytokine production was significantly associated with metal contents of PM1.0: IL-8 correlated with Cr and Mn, and TNF-alpha correlated with Fe and Cr.	Chromium	100-102	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
12694767-14	2003	The unique comparison with Pentoxifylline afforded by this study indicates that at the doses studied Pentoxifylline appears to be superior, correlating with a greater inhibition of IL-8 expression.	Pentoxifylline	101-115	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
12689664-1	2003	A converting activity was characterized in human diploid fibroblasts, which secrete 72IL-8 and 77IL-8 in treatment with IFN-beta and poly I: poly C.	Poly C	141-147	C-X-C motif chemokine ligand 8	Homo sapiens	86-101
12762338-0	2003	Fluticasone reduces IL-6 and IL-8 production of cystic fibrosis bronchial epithelial cells via IKK-beta kinase pathway.	Fluticasone	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
12667212-5	2003	The production of IL-8 and monocyte chemotactic protein 1 (MCP-1) was attenuated by 50% when these cells were preincubated with the p38 MAPK inhibitor, SB 203580.	SB 203580	152-161	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
12723089-4	2003	All muscles treated with NaC and NaF showed the highest pH and glycogen content (P &lt; 0.05), indicating that glycolysis was inhibited.	Glycogen	63-71	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
12689664-2	2003	77IL-8 was significantly converted to 72IL-8 by a partially purified fraction of the culture supernatant of human diploid fibroblasts.	72il-8	38-44	C-X-C motif chemokine ligand 8	Homo sapiens	2-6
12701778-0	2003	Effect of an intraosseous injection of depo-medrol on pulpal concentrations of PGE2 and IL-8 in untreated irreversible pulpitis.	Methylprednisolone Acetate	39-50	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
12679464-9	2003	Treatment of fetal membranes with NAC significantly suppressed lipopolysaccharide-stimulated type II phospholipase A(2) release and content; PGF(2alpha), IL-6, IL-8, TNFalpha, and 8-isoprostane release; and matrix metalloproteinase-9 and urokinase-type plasminogen activator enzyme activity and suppressed NF-kappaB DNA-binding activity (by ANOVA, P &lt; 0.05).	Acetylcysteine	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
14679759-0	2003	[Suppressive mechanism of clarithromycin on lipopolysaccharide-induced IL-8 production in human monocytes by mediating AP-1 and NF-kappaB].	Clarithromycin	26-40	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
12639123-1	2003	The dissolution and complex formation of fluoroaluminates in two eutectic alkalifluoride mixtures, NaF-KF (FNAK) and LiF-NaF-KF (FLINAK), have been investigated by Raman, NMR, and thermal analysis.	fluoroaluminum	41-57	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
12841342-0	2003	The effect of early treatment by cerivastatin on the serum level of C-reactive protein, interleukin-6, and interleukin-8 in the patients with unstable angina and non-Q-wave myocardial infarction.	cerivastatin	33-45	C-X-C motif chemokine ligand 8	Homo sapiens	107-120
12841342-1	2003	The aim of our study was to evaluate whether a single dose of cerivastatin at the time of admission of patients with unstable angina pectoris (UAP) or non-Q-wave myocardial infarction (NQMI) can influence the serum level of C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-8 (IL-8) 24 h later.	cerivastatin	62-74	C-X-C motif chemokine ligand 8	Homo sapiens	275-288
12841342-1	2003	The aim of our study was to evaluate whether a single dose of cerivastatin at the time of admission of patients with unstable angina pectoris (UAP) or non-Q-wave myocardial infarction (NQMI) can influence the serum level of C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-8 (IL-8) 24 h later.	cerivastatin	62-74	C-X-C motif chemokine ligand 8	Homo sapiens	290-294
12628462-4	2003	IL-8 release was measured by ELISA from cells activated for 6 h with TNFalpha (50 ng ml(-1)) in the absence and presence of nicotine (10(-11)-10(-6) M).	Nicotine	124-132	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12628462-7	2003	Nicotine significantly inhibited TNFalpha-induced IL-8 release in a concentration related manner with peak inhibition occurring at 10(-7) M (2.39 +/- 0.78 ng ml(-1), n = 5).	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
12600879-4	2003	The adenosine agonist NECA (100 micromol/L) increased interleukin-8 (IL-8), vascular endothelial growth factor (VEGF), and angiopoietin-2 mRNA expression.	Adenosine-5'-(N-ethylcarboxamide)	22-26	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
12600879-4	2003	The adenosine agonist NECA (100 micromol/L) increased interleukin-8 (IL-8), vascular endothelial growth factor (VEGF), and angiopoietin-2 mRNA expression.	Adenosine-5'-(N-ethylcarboxamide)	22-26	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
12600879-4	2003	The adenosine agonist NECA (100 micromol/L) increased interleukin-8 (IL-8), vascular endothelial growth factor (VEGF), and angiopoietin-2 mRNA expression.	Adenosine	4-13	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
12600879-4	2003	The adenosine agonist NECA (100 micromol/L) increased interleukin-8 (IL-8), vascular endothelial growth factor (VEGF), and angiopoietin-2 mRNA expression.	Adenosine	4-13	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
12600879-6	2003	A2B receptors mediate VEGF and IL-8 secretion because neither CGS21680 (selective A2A agonist) nor IB-MECA (selective A3 agonist) produced this effect, and it was inhibited by the selective A2B antagonist IPDX but not by the selective A2A antagonist SCH58261 or the selective A3 antagonist MRS1191.	3-isobutyl-8-pyrrolidinoxanthine	205-209	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
12600878-0	2003	Glucose regulates monocyte adhesion through endothelial production of interleukin-8.	Glucose	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
12646250-0	2003	Ergothioneine inhibits oxidative stress- and TNF-alpha-induced NF-kappa B activation and interleukin-8 release in alveolar epithelial cells.	Ergothioneine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	89-102
12646250-4	2003	The aim of this study was to determine whether ergothioneine can inhibit the hydrogen peroxide (H(2)O(2))- and TNF-alpha-mediated activation of NF-kappa B and the release of IL-8 in human alveolar epithelial cells (A549).	Ergothioneine	47-60	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
12646250-4	2003	The aim of this study was to determine whether ergothioneine can inhibit the hydrogen peroxide (H(2)O(2))- and TNF-alpha-mediated activation of NF-kappa B and the release of IL-8 in human alveolar epithelial cells (A549).	Hydrogen Peroxide	77-94	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
12646250-4	2003	The aim of this study was to determine whether ergothioneine can inhibit the hydrogen peroxide (H(2)O(2))- and TNF-alpha-mediated activation of NF-kappa B and the release of IL-8 in human alveolar epithelial cells (A549).	Hydrogen Peroxide	96-104	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
12646250-7	2003	Both H(2)O(2) and TNF-alpha significantly increased IL-8 release, which was inhibited by pre-treatment of A549 cells with ergothioneine compared to the control untreated cells.	Hydrogen Peroxide	5-13	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
12646250-7	2003	Both H(2)O(2) and TNF-alpha significantly increased IL-8 release, which was inhibited by pre-treatment of A549 cells with ergothioneine compared to the control untreated cells.	Ergothioneine	122-135	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
12646250-8	2003	Ergothioneine also abolished the transcriptional activation of IL-8 in an IL-8-chloramphenicol acetyltransferase (CAT) reporter system, transfected into A549 cells.	Ergothioneine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
12646250-8	2003	Ergothioneine also abolished the transcriptional activation of IL-8 in an IL-8-chloramphenicol acetyltransferase (CAT) reporter system, transfected into A549 cells.	Ergothioneine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
12600878-6	2003	Analysis of the human IL-8 promoter revealed binding sites for NF-kappaB and AP-1 as well as several aligned carbohydrate response elements (also known as E-boxes).	Carbohydrates	109-121	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
12600878-7	2003	Glucose dramatically stimulated IL-8 promoter activity.	Glucose	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
12600878-8	2003	Using mutated IL-8 promoter constructs and EMSA, we found that the AP-1 element and the glucose-response element were responsible for much of the glucose-mediated activation of IL-8 transcription.	Glucose	88-95	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
12627953-9	2003	In contrast, in CXCR2-RBL cells the migration-attenuating concentrations of IL-8 induced promoted levels of FAK phosphorylation and different patterns of FAK phosphorylation on its six potential tyrosine phosphorylation sites, as compared to activating concentrations of the chemokine.	Tyrosine	195-203	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
12600878-2	2003	HAECs cultured for 7 days in 25 mmol/L glucose had a 2-fold elevation in interleukin-8 (IL-8) secretion over control cells cultured in 5.5 mmol/L glucose (P&lt;0.001).	Glucose	39-46	C-X-C motif chemokine ligand 8	Homo sapiens	73-86
12600878-8	2003	Using mutated IL-8 promoter constructs and EMSA, we found that the AP-1 element and the glucose-response element were responsible for much of the glucose-mediated activation of IL-8 transcription.	Glucose	146-153	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
12600878-8	2003	Using mutated IL-8 promoter constructs and EMSA, we found that the AP-1 element and the glucose-response element were responsible for much of the glucose-mediated activation of IL-8 transcription.	Glucose	146-153	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
12600878-2	2003	HAECs cultured for 7 days in 25 mmol/L glucose had a 2-fold elevation in interleukin-8 (IL-8) secretion over control cells cultured in 5.5 mmol/L glucose (P&lt;0.001).	Glucose	39-46	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
12600878-9	2003	Interestingly, inhibition of reactive oxygen species (ROS) production through use of pharmacological uncouplers of the mitochondrial electron transport chain significantly reduced glucose-mediated induction of IL-8 expression.	Reactive Oxygen Species	29-52	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
12600878-3	2003	Use of a neutralizing antibody to IL-8 prevented glucose-mediated monocyte adhesion.	Glucose	49-56	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
12600878-9	2003	Interestingly, inhibition of reactive oxygen species (ROS) production through use of pharmacological uncouplers of the mitochondrial electron transport chain significantly reduced glucose-mediated induction of IL-8 expression.	Reactive Oxygen Species	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
12600878-9	2003	Interestingly, inhibition of reactive oxygen species (ROS) production through use of pharmacological uncouplers of the mitochondrial electron transport chain significantly reduced glucose-mediated induction of IL-8 expression.	Glucose	180-187	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
12695126-1	2003	The CXC-chemokines Groalpha and interleukin-8 (IL-8) are ligands for two different G protein-coupled receptors, named CXC-chemokine receptor I &amp; II (CXCRI &amp; II).	Adenosine Monophosphate	144-147	C-X-C motif chemokine ligand 8	Homo sapiens	32-45
12600878-10	2003	These data indicate that glucose regulates monocyte:endothelial interactions through stimulation of IL-8 and ROS production and activation of the alpha5beta1 integrin complex on HAECs.	Glucose	25-32	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
12573991-5	2003	PM(10) and H(2)O(2) increased IL-8 protein release from A549 cells after 24-h treatment, and this was enhanced by histone deacetylase inhibition by trichostatin A (cotreatment).	trichostatin A	148-162	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
12653753-8	2003	Relative levels of transcripts for IL-8, MIP-1alpha, TNF-alpha and IL-2 were lower at the end of each individual DFPP and after the four treatments than at the beginning of treatment.	dfpp	113-117	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
12650786-12	2003	Again, the IL-8 levels were significantly decreased after lansoprazole treatment.	Lansoprazole	58-70	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
12695126-1	2003	The CXC-chemokines Groalpha and interleukin-8 (IL-8) are ligands for two different G protein-coupled receptors, named CXC-chemokine receptor I &amp; II (CXCRI &amp; II).	Adenosine Monophosphate	144-147	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
12695126-1	2003	The CXC-chemokines Groalpha and interleukin-8 (IL-8) are ligands for two different G protein-coupled receptors, named CXC-chemokine receptor I &amp; II (CXCRI &amp; II).	Adenosine Monophosphate	160-163	C-X-C motif chemokine ligand 8	Homo sapiens	32-45
12695126-1	2003	The CXC-chemokines Groalpha and interleukin-8 (IL-8) are ligands for two different G protein-coupled receptors, named CXC-chemokine receptor I &amp; II (CXCRI &amp; II).	Adenosine Monophosphate	160-163	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
12629150-5	2003	The Fas agonistic antibody CH-11 dose-dependently stimulated the expression of IL-6 and IL-8 in glioma cells.	4-dimethylamino-3',4'-dimethoxychalcone	27-32	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
12703484-5	2003	The predicted IL-8 peptide had one potential N-linked glycosylation site (Asn-72-Thr-74) that is not conserved in other vertebrates.	Nitrogen	45-46	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
12555204-6	2003	We found that QUIN induces astrocytes to produce large quantities of MCP-1 (CCL2) and lesser amounts of RANTES (CCL5) and IL-8 (CXCL8).	Quinolinic Acid	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
12555204-6	2003	We found that QUIN induces astrocytes to produce large quantities of MCP-1 (CCL2) and lesser amounts of RANTES (CCL5) and IL-8 (CXCL8).	Quinolinic Acid	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	128-133
12580917-6	2003	RESULTS: Using H292 cells, EGF and H2O2 increased IL-8 gene expression and release and this was completely suppressed by the EGFR-selective tyrosine kinase inhibitor, AG1478, but only partially by dexamethasone.	Hydrogen Peroxide	35-39	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
12393592-1	2003	Some cases of heparin-induced thrombocytopenia (HIT) have been reported to be associated with antibodies against interleukin-8 (IL-8), a chemokine related to platelet factor 4.	Heparin	14-21	C-X-C motif chemokine ligand 8	Homo sapiens	113-126
12393592-1	2003	Some cases of heparin-induced thrombocytopenia (HIT) have been reported to be associated with antibodies against interleukin-8 (IL-8), a chemokine related to platelet factor 4.	Heparin	14-21	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
12576442-8	2003	All six anti-inflammatory agents suppressed induction of IL-8 mRNA expression in lung cancer cells by &gt;90%, four (pentoxifylline, celecoxib, pyrrolidine dithiocarbamate, and dexamethasone) having a dose-dependent effect.	Pentoxifylline	117-131	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
12576442-8	2003	All six anti-inflammatory agents suppressed induction of IL-8 mRNA expression in lung cancer cells by &gt;90%, four (pentoxifylline, celecoxib, pyrrolidine dithiocarbamate, and dexamethasone) having a dose-dependent effect.	Celecoxib	133-142	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
12576442-8	2003	All six anti-inflammatory agents suppressed induction of IL-8 mRNA expression in lung cancer cells by &gt;90%, four (pentoxifylline, celecoxib, pyrrolidine dithiocarbamate, and dexamethasone) having a dose-dependent effect.	pyrrolidine dithiocarbamic acid	144-171	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
12393592-3	2003	This activation occurred at IL-8 concentrations achievable in vivo and was facilitated by heparin (0.1 U/mL).	Heparin	90-97	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
12580917-6	2003	RESULTS: Using H292 cells, EGF and H2O2 increased IL-8 gene expression and release and this was completely suppressed by the EGFR-selective tyrosine kinase inhibitor, AG1478, but only partially by dexamethasone.	RTKI cpd	167-173	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
12576442-8	2003	All six anti-inflammatory agents suppressed induction of IL-8 mRNA expression in lung cancer cells by &gt;90%, four (pentoxifylline, celecoxib, pyrrolidine dithiocarbamate, and dexamethasone) having a dose-dependent effect.	Dexamethasone	177-190	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
12629330-0	2003	Dual response to Fas ligation in human endothelial cells: apoptosis and induction of chemokines, interleukin-8 and monocyte chemoattractant protein-1.	ammonium ferrous sulfate	17-20	C-X-C motif chemokine ligand 8	Homo sapiens	97-110
12629330-4	2003	We also investigated whether an inhibitor of caspase-8 (Z-IETD-FMK) does modulate IL-8 and MCP-1 secretion.	benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone	56-66	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
12576957-9	2003	Patients fed EPA+GLA had a significant reduction in BALF ceruloplasmin and IL-8 during the study as compared with patients fed the control diet.	epa+gla	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
12629330-9	2003	Fas-neutralizing agent (Fas-Fc) suppressed the Fas-mediated secretions of IL-8 and MCP-1 (P &lt; 0.01) both as well as the Fas-mediated apoptosis.	ammonium ferrous sulfate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
12629330-9	2003	Fas-neutralizing agent (Fas-Fc) suppressed the Fas-mediated secretions of IL-8 and MCP-1 (P &lt; 0.01) both as well as the Fas-mediated apoptosis.	ammonium ferrous sulfate	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
12629330-9	2003	Fas-neutralizing agent (Fas-Fc) suppressed the Fas-mediated secretions of IL-8 and MCP-1 (P &lt; 0.01) both as well as the Fas-mediated apoptosis.	ammonium ferrous sulfate	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
12629330-9	2003	Fas-neutralizing agent (Fas-Fc) suppressed the Fas-mediated secretions of IL-8 and MCP-1 (P &lt; 0.01) both as well as the Fas-mediated apoptosis.	ammonium ferrous sulfate	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
12629330-10	2003	On the other hand, whereas Z-IETD-FMK suppressed apoptosis, the inhibitor enhanced the Fas-mediated secretions of both IL-8 and MCP-1 beyond the value of the Fas stimulation alone (P &lt; 0.01), suggesting an enhanced signalling for the chemokine expression.	benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone	27-37	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
12629330-10	2003	On the other hand, whereas Z-IETD-FMK suppressed apoptosis, the inhibitor enhanced the Fas-mediated secretions of both IL-8 and MCP-1 beyond the value of the Fas stimulation alone (P &lt; 0.01), suggesting an enhanced signalling for the chemokine expression.	ammonium ferrous sulfate	87-90	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
12588289-8	2003	Additionally, serum IL-1beta, IL-6 and, especially, IL-8 levels were significantly higher in the subjects with than in those without ABG (P &lt; 0.0001, for all cytokines).	abg	133-136	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
12588289-12	2003	CONCLUSIONS: The ratio between serum IL-8 and pepsinogen A/C accurately predicts the presence of ABG.	abg	97-100	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
12586608-4	2003	CS and CT strongly inhibited the production of proinflammatory cytokines (IL-1alpha, IL-1beta, IL-6, IL-8, and TNF-alpha) from LPS-stimulated human monocytes.	Cesium	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
12586608-4	2003	CS and CT strongly inhibited the production of proinflammatory cytokines (IL-1alpha, IL-1beta, IL-6, IL-8, and TNF-alpha) from LPS-stimulated human monocytes.	ct	7-9	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
12588890-12	2003	In conclusion, albumin is a strong stimulus for tubular IL-8 expression, which occurs via NF-kappaB-dependent pathways through PKC activation and ROS generation.	Reactive Oxygen Species	146-149	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
12574206-5	2003	The NF-kappa B inhibitor, N-tosyl-L-phenylalanine chloromethyl ketone, reduced TNFalpha-induced IL-8 gene and protein expression.	Tosylphenylalanyl Chloromethyl Ketone	26-69	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
12574206-9	2003	The addition of estradiol (E2; 10(-7) M) enhanced the expression of IL-8.	Estradiol	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
12588890-7	2003	NF-kappaB activation and IL-8 secretion were attenuated by the NF-kappaB inhibitors pyrrolidine dithiocarbamate and cell-permeable peptide.	pyrrolidine dithiocarbamic acid	84-111	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
12588890-8	2003	Albumin upregulated intracellular reactive oxygen species (ROS) generation, while exogenous H2O2 stimulated NF-kappaB translocation and IL-8 secretion.	Hydrogen Peroxide	92-96	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
12588890-9	2003	Albumin-induced ROS generation, NF-kappaB activation, and IL-8 secretion were endocytosis- and PKC-dependent as these downstream events were abrogated by the PI3K inhibitors LY294002 and wortmannin, and the PKC inhibitors GF109203X and staurosporin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
12588890-9	2003	Albumin-induced ROS generation, NF-kappaB activation, and IL-8 secretion were endocytosis- and PKC-dependent as these downstream events were abrogated by the PI3K inhibitors LY294002 and wortmannin, and the PKC inhibitors GF109203X and staurosporin, respectively.	Wortmannin	187-197	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
12504339-9	2003	Overall, PB infusion caused a decrease or IL-8 and PGE(2) release.	Pyridostigmine Bromide	9-11	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
12646971-5	2003	Plasma and bronchoalveolar lavage fluid (BALF) IL-8 levels in the control group were significantly higher than those in the steroid group.	Steroids	124-131	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
12594001-11	2003	IL-8 produced by CSMCs in response to gram-negative infection may promote neutrophil invasion, and release of neutrophil matrix-degrading enzymes may participate in the matrix remodeling associated with parturition.	csmcs	17-22	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12745544-9	2003	Clearance of IL-8 increased by 0.47+/-0.08 pg/ml for each unit increase in pre-dialysis IL-8 (p&lt;0.001) and decreased by 5.63+/-2.59 pg/ml for each unit increase in pre-dialysis urea mmol/l (p&lt;0.05).	Urea	180-184	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
12504339-12	2003	IL-8 was assayed at 1, 2, 4, 8, 12 and 24 h. PB suppressed IL-8 in permethrin and ethanol treatment from 4 to 24 h confirming the IPPSF results.	Permethrin	67-77	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
12554889-10	2003	Moreover, there was a significant negative correlation between peroxynitrite inhibitory activity and the degree of neutrophilic inflammation (percentage of neutrophils: r=-0.754, p&lt;0.001; IL-8 levels: r=-0.497, p=0.007).	Peroxynitrous Acid	63-76	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
12504339-13	2003	In conclusion, these studies suggest that systemic exposure to PB suppressed IL-8 release at multiple time points in two skin model systems.	Pyridostigmine Bromide	63-65	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
12406856-2	2003	We investigated the effect of dexamethasone on basal and interleukin (IL)-1beta or cigarette smoke media (CSM)-stimulated release of IL-8 and granulocyte macrophage-colony stimulating factor (GM-CSF) by bronchoalveolar lavage macrophages from cigarette smokers and patients with COPD (n = 15).	Dexamethasone	30-43	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
12471616-7	2003	In contrast, highly tumorigenic and metastatic 451Lu cells showed marked increases in tumor growth and number of metastatic foci in the lungs depending on the expression levels of IL-8.	451lu	47-52	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
12505195-0	2003	Pyrrolidinedithiocarbamate inhibits NF-kappaB activation and IL-8 production in intestinal epithelial cells.	pyrrolidine dithiocarbamic acid	0-26	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
12505195-4	2003	In the present paper we investigated the effect of pharmacological inhibition of NF-kappaB with pyrrolidinedithiocarbamate (PDTC) on IL-1beta-induced IL-8 production by the human intestinal epithelial cell line HT-29.	pyrrolidine dithiocarbamic acid	96-122	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
12505195-4	2003	In the present paper we investigated the effect of pharmacological inhibition of NF-kappaB with pyrrolidinedithiocarbamate (PDTC) on IL-1beta-induced IL-8 production by the human intestinal epithelial cell line HT-29.	pyrrolidine dithiocarbamic acid	124-128	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
12471621-0	2003	Induction of IL-8 and monoclyte chemoattractant protein-1 by doxorubicin in human small cell lung carcinoma cells.	Doxorubicin	61-72	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
12471621-3	2003	We have, therefore, extended the observation by testing the effects of doxorubicin on expression of the chemokine family and provide here definitive evidence that doxorubicin induces IL-8 and MCP-1, one of the CC chemokines, at least in 2 human SCLC cells, H69 and SBC-1.	Doxorubicin	163-174	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
12471621-4	2003	IL-8 antigen levels, measured by ELISA, were markedly increased in both H69 and SBC-1 conditioned media after doxorubicin treatment, in parallel with mRNA levels; and this was dependent on the dose of doxorubicin.	Doxorubicin	110-121	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12471621-4	2003	IL-8 antigen levels, measured by ELISA, were markedly increased in both H69 and SBC-1 conditioned media after doxorubicin treatment, in parallel with mRNA levels; and this was dependent on the dose of doxorubicin.	Doxorubicin	201-212	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12471621-5	2003	The ribonuclease protection assay, using a multiprobe template set for human chemokines, revealed induction of not only IL-8 but also MCP-1 in doxorubicin-treated H69 cells.	Doxorubicin	143-154	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
12471621-10	2003	IL-8 and MCP-1 are major chemoattractants for neutrophils and monocytes/macrophages, respectively; therefore, extensive induction of IL-8 and MCP-1 may provoke the interaction between inflammatory/immune cells and tumor cells under doxorubicin stimulation and influence many aspects of tumor cell biology.	Doxorubicin	232-243	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12471621-10	2003	IL-8 and MCP-1 are major chemoattractants for neutrophils and monocytes/macrophages, respectively; therefore, extensive induction of IL-8 and MCP-1 may provoke the interaction between inflammatory/immune cells and tumor cells under doxorubicin stimulation and influence many aspects of tumor cell biology.	Doxorubicin	232-243	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
15206714-6	2003	We found that QUIN induces astrocytes to produce large quantities of MCP-1 (CCL2), and lesser amounts of RANTES (CCL5), IL-8 (CXCL8).	Quinolinic Acid	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
15206714-6	2003	We found that QUIN induces astrocytes to produce large quantities of MCP-1 (CCL2), and lesser amounts of RANTES (CCL5), IL-8 (CXCL8).	Quinolinic Acid	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	126-131
12507912-2	2003	The present study was undertaken to evaluate the effects of anti-inflammatory cytokine interleukin-10 (IL-10) on NaCl-induced chemokine IL-8 and regulated on activation normal T cell expressed and secreted (RANTES) expression through the NF-kappaB signaling in primary deltaF508 CF and non-CF (control) human bronchial epithelial cells.	Sodium Chloride	113-117	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
12507912-4	2003	Compared to non-CF cells, CF bronchial epithelial cells were characterized by a higher susceptibility to produce elevated IL-8 and RANTES production in an hypertonic NaCl milieu in response to IL-1beta activation.	Sodium Chloride	166-170	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
12393716-7	2003	By contrast, the induction of interleukin-8 was delayed and was found to be cyclosporine insensitive.	Cyclosporine	76-88	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
14646051-1	2003	Introducing the theory of fuzzy set, mathematical morphology and computerized mask fast scanning, we developed the TOOTH.SCA software and method to analyze the effect of fluoride (NaF) on ore content of human tooth enamel automatically and quantitatively.	Fluorides	170-178	C-X-C motif chemokine ligand 8	Homo sapiens	180-183
12419628-6	2003	When the NaF concentration was higher than 0.1%, the protectiveness of TiO(2) passive film formed on Ti-6Al-4V alloy was destroyed by fluoride ions, leading to the formation of Na(2)TiF(6).	tio	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
12419628-6	2003	When the NaF concentration was higher than 0.1%, the protectiveness of TiO(2) passive film formed on Ti-6Al-4V alloy was destroyed by fluoride ions, leading to the formation of Na(2)TiF(6).	Fluorides	134-142	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
12419628-6	2003	When the NaF concentration was higher than 0.1%, the protectiveness of TiO(2) passive film formed on Ti-6Al-4V alloy was destroyed by fluoride ions, leading to the formation of Na(2)TiF(6).	na(2)tif	177-185	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
12600410-0	2003	Modulation of interleukin-8 and nitric oxide synthase mRNA levels by interferon-gamma in macrophages stimulated with lignin derivatives and lipopolysaccharides.	Lignin	117-123	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
12519386-3	2003	IL-8 promoter activity in IEC pretreated with butyrate then exposed to proinflammatory stimuli was assayed by transfection of luciferase constructs.	Butyrates	46-54	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
14642531-4	2003	This polarity did not correlate with glycosylation, as IL-8 and MIC-1 are both N-glycosylated, but were sorted to opposite sides of the cell.	Nitrogen	79-80	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
12788054-7	2003	Hydrocortisone at a dose, which inhibits cell death also down regulated, the expression of pro-inflammatory cytokines IL-6 and IL-8.	Hydrocortisone	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
12519386-9	2003	Pharmacological inhibition of protein tyrosine phosphatases or treatment with mesalamine or sulphasalazine diminished IL-1 beta-stimulated IL-8 secretion by butyrate-exposed HT-29 cells substantially.	Sulfasalazine	92-106	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
12519386-6	2003	Butyrate modulated proinflammatory IL-8 secretion differentially in Caco-2 and HT-29 cells on the transcriptional level.	Butyrates	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
12519386-9	2003	Pharmacological inhibition of protein tyrosine phosphatases or treatment with mesalamine or sulphasalazine diminished IL-1 beta-stimulated IL-8 secretion by butyrate-exposed HT-29 cells substantially.	Butyrates	157-165	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
12538487-8	2003	Inhibiting NFkappaB activation by expressing IkappaBalphaM and using pharmacologic NFkappaB inhibitor PS-341 also significantly reduced cytokine-induced vascular endothelial growth factor and interleukin-8 expression in AsPc-1 pancreatic cancer cells.	Bortezomib	102-108	C-X-C motif chemokine ligand 8	Homo sapiens	192-205
12519386-11	2003	Pharmacological inhibition of enhanced IL-1 beta-mediated IL-8 secretion in a subpopulation of IEC may improve the clinical efficacy of butyrate.	Butyrates	136-144	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
12519386-7	2003	Pointing to the potentially underlying mechanism of increased IL-1 beta-stimulated IL-8 secretion in HT-29 cells, butyrate up-regulated IL-1RI mRNA but not IL-1RII.	Butyrates	114-122	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
12519386-9	2003	Pharmacological inhibition of protein tyrosine phosphatases or treatment with mesalamine or sulphasalazine diminished IL-1 beta-stimulated IL-8 secretion by butyrate-exposed HT-29 cells substantially.	Mesalamine	78-88	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
12498928-7	2003	We conclude that in HT-29 cells, TNF-alpha-induced interleukin-8 release is inhibited by cannabinoids through activation of cannabinoid CB(2) receptors.	Cannabinoids	89-101	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
12498928-0	2003	Inhibition of interleukin-8 release in the human colonic epithelial cell line HT-29 by cannabinoids.	Cannabinoids	87-99	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
12499080-2	2003	MEM significantly inhibited PMA-induced secretions of IL-8 and MCP-1 proteins in a dose-dependent manner.	Tetradecanoylphorbol Acetate	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
12498928-1	2003	We have investigated the effects of cannabinoid agonists and antagonists on tumour necrosis factor-alpha (TNF-alpha)-induced secretion of interleukin-8 from the colonic epithelial cell line, HT-29.	Cannabinoids	36-47	C-X-C motif chemokine ligand 8	Homo sapiens	138-151
12458377-13	2003	Butyrate down-regulated TLR 4 expression and significantly diminished LPS-dependent IL-8 secretion.	Butyrates	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
14595851-4	2003	Furthermore, macroarray analysis showed that naphthalene modified cord blood gene expression, inducing IL-8 precursor and T-cell transcription factor and decreasing the level of RNA-binding protein FUS/TLS.	naphthalene	45-56	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
12499080-4	2003	In addition, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 proteins by its suppression of IL-8 and MCP-1 genes.	beta-penta-O-galloyl-glucose	13-53	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
12499080-4	2003	In addition, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 proteins by its suppression of IL-8 and MCP-1 genes.	beta-penta-O-galloyl-glucose	13-53	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
12499080-4	2003	In addition, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 proteins by its suppression of IL-8 and MCP-1 genes.	Tetradecanoylphorbol Acetate	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
12499080-4	2003	In addition, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 proteins by its suppression of IL-8 and MCP-1 genes.	Tetradecanoylphorbol Acetate	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
12556010-0	2003	Effects by 8-bromo-cyclicAMP on basal and organic dust-induced release of interleukin-6 and interleukin-8 in A549 human airway epithelial cells.	8-Bromo Cyclic Adenosine Monophosphate	11-28	C-X-C motif chemokine ligand 8	Homo sapiens	92-105
12544908-6	2003	RESULTS: Increases in IL-8, IL-6, and IL-10 were greater in patients resuscitated with PRBCs.	prbcs	87-92	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
12934311-4	2003	Carvedilol group of patients demonstrated a marked trend to reduction of the number of hospitalizations, attenuation of CCF, better tolerance to exercise, lower levels of uric acid (p &lt; 0.05), malonic dialdehyde (p &lt; 0.05) and IL-8 (p = 0.09).	Carvedilol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	233-237
12490594-9	2003	Activation of the epidermal VR1 by capsaicin also resulted in an increased release of interleukin-8 and prostaglandin E2, and the stimulated release was attenuated by capsazepine.	Capsaicin	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	86-99
12490594-9	2003	Activation of the epidermal VR1 by capsaicin also resulted in an increased release of interleukin-8 and prostaglandin E2, and the stimulated release was attenuated by capsazepine.	capsazepine	167-178	C-X-C motif chemokine ligand 8	Homo sapiens	86-99
14605444-0	2003	Depolymerization of actin filament by cytochalasin E induces interleukin-8 production and up-regulates CD54 in the HeLa epithelial cell line.	cytochalasin E	38-52	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
14605444-4	2003	In this study, we found that cytochalasin E strongly induces interleukin-8 through an epithelial cell line, HeLa, in dose- and time-dependent manners as assessed by enzyme-linked immunoassay and reverse transcription-polymerase chain reaction techniques.	cytochalasin E	29-43	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
14605444-5	2003	In addition, interleukin-8 production in the HeLa cells cultured with cytochalasin E was blocked in the presence of protein kinase C inhibitors, Go6976 and H-7.	cytochalasin E	70-84	C-X-C motif chemokine ligand 8	Homo sapiens	13-26
14605444-5	2003	In addition, interleukin-8 production in the HeLa cells cultured with cytochalasin E was blocked in the presence of protein kinase C inhibitors, Go6976 and H-7.	Go 6976	145-151	C-X-C motif chemokine ligand 8	Homo sapiens	13-26
14605444-7	2003	Taken together, these findings indicate that cytochalasin E activates protein kinase C under the depolymerization of actin filament, leading to the induction of interleukin-8 production and the up-regulation of CD54 in HeLa cells.	cytochalasin E	45-59	C-X-C motif chemokine ligand 8	Homo sapiens	161-174
12556010-4	2003	We therefore investigated whether 8-Bromo-cAMP, a cell membrane-permeable cAMP analogue, would influence release of the cytokines interleukin-6 (IL-6) and IL-8 in a human airway epithelial cell line, A549, exposed to a suspension of the organic dust, and to a supernatant prepared by centrifugation (at low g-force) of a suspension of dust.	8-Bromo Cyclic Adenosine Monophosphate	34-46	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
12556010-4	2003	We therefore investigated whether 8-Bromo-cAMP, a cell membrane-permeable cAMP analogue, would influence release of the cytokines interleukin-6 (IL-6) and IL-8 in a human airway epithelial cell line, A549, exposed to a suspension of the organic dust, and to a supernatant prepared by centrifugation (at low g-force) of a suspension of dust.	Cyclic AMP	42-46	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
12556010-9	2003	8-Bromo-cAMP did not affect basal IL-8 release, partially inhibited (28%) the release of IL-8 induced by a dust suspension (P&lt;0.01), but increased IL-8 release induced by a dust supernatant by 13% (P&lt;0.05).	8-Bromo Cyclic Adenosine Monophosphate	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
12556010-9	2003	8-Bromo-cAMP did not affect basal IL-8 release, partially inhibited (28%) the release of IL-8 induced by a dust suspension (P&lt;0.01), but increased IL-8 release induced by a dust supernatant by 13% (P&lt;0.05).	8-Bromo Cyclic Adenosine Monophosphate	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
12556010-10	2003	In summary, expression of the cytokines IL-6 and IL-8 is differentially regulated by 8-Bromo-cAMP, both with regard to basal and dust-induced release.	8-Bromo Cyclic Adenosine Monophosphate	85-97	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
12556010-11	2003	The results indicate that 8-Bromo-cAMP attenuated IL-8 release by affecting signaling transductions induced by the particulate fraction.	8-Bromo Cyclic Adenosine Monophosphate	26-38	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
12492348-1	2002	The [1 + 2] cycloaddition reaction of 1-iodoalkynes with difluorocarbene, generated from the decomposition of FSO(2)CF(2)COOSiMe(3) in diglyme in the presence of 10 mol % NaF at 120 degrees C, gives 3,3-difluoro-1-iodocyclopropenes in good yields.	1-iodoalkynes	38-51	C-X-C motif chemokine ligand 8	Homo sapiens	171-174
12729367-4	2003	It has been hypothesized that the link between cisplatin treatment and FMF attacks lies in an increased production of serotonin, IL-6, IL-1, IL-8 and TNF-alpha.	Cisplatin	47-56	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
12492348-1	2002	The [1 + 2] cycloaddition reaction of 1-iodoalkynes with difluorocarbene, generated from the decomposition of FSO(2)CF(2)COOSiMe(3) in diglyme in the presence of 10 mol % NaF at 120 degrees C, gives 3,3-difluoro-1-iodocyclopropenes in good yields.	difluorocarbene	57-72	C-X-C motif chemokine ligand 8	Homo sapiens	171-174
12492348-1	2002	The [1 + 2] cycloaddition reaction of 1-iodoalkynes with difluorocarbene, generated from the decomposition of FSO(2)CF(2)COOSiMe(3) in diglyme in the presence of 10 mol % NaF at 120 degrees C, gives 3,3-difluoro-1-iodocyclopropenes in good yields.	diglyme	135-142	C-X-C motif chemokine ligand 8	Homo sapiens	171-174
12471139-6	2002	Depletion of tryptophan led to stabilization of IL-6 and IL-8 mRNA and increased IL-6 and IL-8 responses, whereas supplementing tryptophan largely restored these changes.	Tryptophan	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
12471139-6	2002	Depletion of tryptophan led to stabilization of IL-6 and IL-8 mRNA and increased IL-6 and IL-8 responses, whereas supplementing tryptophan largely restored these changes.	Tryptophan	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
12413740-7	2002	Increased IL-8 secretion due to endomorphin-1 could be blocked by pre-incubating cells with the mu receptor antagonist, beta-funaltrexamine.	beta-funaltrexamine	120-139	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
12432545-0	2002	The copper chelator trientine has an antiangiogenic effect against hepatocellular carcinoma, possibly through inhibition of interleukin-8 production.	Copper	4-10	C-X-C motif chemokine ligand 8	Homo sapiens	124-137
12432545-0	2002	The copper chelator trientine has an antiangiogenic effect against hepatocellular carcinoma, possibly through inhibition of interleukin-8 production.	Trientine	20-29	C-X-C motif chemokine ligand 8	Homo sapiens	124-137
12432545-10	2002	The production of IL-8 from the tumor was suppressed by trientine.	Trientine	56-65	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
12432545-11	2002	In vitro, IL-8 production by HuH-7 cells in copper-containing medium was significantly greater than that in copper-free medium, and this effect was weakened when trientine was added.	Copper	44-50	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
12432545-11	2002	In vitro, IL-8 production by HuH-7 cells in copper-containing medium was significantly greater than that in copper-free medium, and this effect was weakened when trientine was added.	Copper	108-114	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
12432545-11	2002	In vitro, IL-8 production by HuH-7 cells in copper-containing medium was significantly greater than that in copper-free medium, and this effect was weakened when trientine was added.	Trientine	162-171	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
12432545-13	2002	In conclusion, the chelating effect of trientine prevented copper from functioning as a cofactor in angiogenesis, which resulted in reduced IL-8 production from HuH-7 cells.	Trientine	39-48	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
12432545-13	2002	In conclusion, the chelating effect of trientine prevented copper from functioning as a cofactor in angiogenesis, which resulted in reduced IL-8 production from HuH-7 cells.	Copper	59-65	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
12452835-6	2002	In the A549 cells, gp-340 was up-regulated along with the PMA-induced proinflammatory expression of both IL-6 and IL-8.	Tetradecanoylphorbol Acetate	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
12558191-8	2002	IL-8 "hyper-responders" experienced significantly greater postoperative weight gain and had higher IL-8 levels at 24 h (p&lt;0.05), with trends towards renal impairment and protracted supplemental oxygen requirements.	Oxygen	197-203	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12442335-6	2002	The presence of wortmannin during receptor recycling inhibited CXCR1 and CXCR2 re-expression following CXCL8-induced internalization, and resulted in a marked disruption of the proper organization of actin filaments.	Wortmannin	16-26	C-X-C motif chemokine ligand 8	Homo sapiens	103-108
12438368-3	2002	As CAP37 and protamines share high levels of arginine content, we tested different synthetic poly-L-amino acids and found that poly-L-arginine, and to a lesser extent poly-L-lysine, increased IL-8 production in LPS-stimulated human whole blood.	polyarginine	127-142	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
12438368-3	2002	As CAP37 and protamines share high levels of arginine content, we tested different synthetic poly-L-amino acids and found that poly-L-arginine, and to a lesser extent poly-L-lysine, increased IL-8 production in LPS-stimulated human whole blood.	Lysine	167-180	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
12473064-3	2002	Lipopolysaccharide stimulated IL-8 production in 8-MOP-phototreated PBMC more efficiently than those untreated or treated with 8-MOP or UVA.	Methoxsalen	49-54	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
12488495-7	2002	These findings suggest that ethanol may modulate three major cytokines involved in alcoholic liver diseases, IL-8, TNF-alpha, and HGF, via three different mechanisms.	Ethanol	28-35	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
12444152-3	2002	In the present study, we demonstrate that a potent and selective nonpeptide antagonist of human CXCR2 potently inhibits (125)I-labeled human IL-8 binding to, and human IL-8-induced calcium mobilization mediated by, rabbit CXCR2 (IC(50) = 40.5 and 7.7 nM, respectively), but not rabbit CXCR1 (IC(50) = &gt;1000 and 2200 nM, respectively).	Calcium	181-188	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
12444152-3	2002	In the present study, we demonstrate that a potent and selective nonpeptide antagonist of human CXCR2 potently inhibits (125)I-labeled human IL-8 binding to, and human IL-8-induced calcium mobilization mediated by, rabbit CXCR2 (IC(50) = 40.5 and 7.7 nM, respectively), but not rabbit CXCR1 (IC(50) = &gt;1000 and 2200 nM, respectively).	Calcium	181-188	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
12379337-2	2002	Two main forms of IL-8 exist, one containing 77 amino acids (Ala-IL-8(77)) and a second containing 72 amino acids (Ser-IL-8(72)), which comprise more than 90% of IL-8 protein in cell cultures.	Alanine	61-64	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
12379337-2	2002	Two main forms of IL-8 exist, one containing 77 amino acids (Ala-IL-8(77)) and a second containing 72 amino acids (Ser-IL-8(72)), which comprise more than 90% of IL-8 protein in cell cultures.	Serine	115-118	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
12457984-4	2002	Both orfvIL-10 and ovIL-10 inhibited TNF-alpha and IL-8 cytokine production from stimulated ovine macrophages and keratinocytes and IFN-gamma and GM-CSF production from peripheral blood lymphocytes.	orfvil-10	5-14	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
12427122-6	2002	RESULTS: Endocytosis of LCs induced the release of interleukins (IL) IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1); however, there was considerable variability among the six different LCs.	lcs	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
12460404-6	2002	There were no significant differences in IL-8 levels before and after treatment in the PE group, but the IL-8 level was significantly lower after treatment in the PE+CHDF group.	chdf	166-170	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
12457984-4	2002	Both orfvIL-10 and ovIL-10 inhibited TNF-alpha and IL-8 cytokine production from stimulated ovine macrophages and keratinocytes and IFN-gamma and GM-CSF production from peripheral blood lymphocytes.	ovil-10	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
12215436-4	2002	PGE(2) (50 nm) attenuated LPS-induced mRNA and protein expression of chemokines including monocyte chemoattractant protein-1, interleukin-8, macrophage inflammatory protein-1alpha and -1beta, and interferon-inducible protein-10.	Prostaglandins E	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	126-139
12427973-4	2002	The proangiogenic N-terminal fragment mini-TyrRS has IL-8-like cytokine activity that, like other CXC cytokines, depends on a Glu-Leu-Arg motif.	Glutamic Acid	126-129	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
12427973-4	2002	The proangiogenic N-terminal fragment mini-TyrRS has IL-8-like cytokine activity that, like other CXC cytokines, depends on a Glu-Leu-Arg motif.	Leucine	130-133	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
12427973-4	2002	The proangiogenic N-terminal fragment mini-TyrRS has IL-8-like cytokine activity that, like other CXC cytokines, depends on a Glu-Leu-Arg motif.	Arginine	134-137	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
12457713-7	2002	Stimulations of cAMP with NaF or forskolin were the same as in control cells.	Cyclic AMP	16-20	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
12427655-5	2002	Reconstitution studies demonstrated that the oleic and linoleic acids associated with E-LDL are particularly effective IL-8 inducers.	oleic	45-50	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
12427655-5	2002	Reconstitution studies demonstrated that the oleic and linoleic acids associated with E-LDL are particularly effective IL-8 inducers.	Linoleic Acids	55-69	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
12427655-7	2002	CONCLUSION: IL-8 is required for rolling monocytes to adhere firmly to the endothelium; thus, the findings reveal a link between subendothelial entrapment of LDL, cleavage of cholesterol esters, and monocyte recruitment into the lesion.	Cholesterol Esters	175-193	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
12415153-1	2002	Lithium sodium aluminium fluoride was obtained as a white powder by melting a stoichiometric mixture of AlF(3), NaF and LiF at 1223 K, and then cooling to 923 K and sintering at this temperature for 4 h. The ab initio crystal structure determination was carried out using X-ray powder diffraction techniques.	lithium sodium aluminium fluoride	0-33	C-X-C motif chemokine ligand 8	Homo sapiens	112-115
12485902-4	2002	Thalidomide inhibited interleukin (IL) 1beta-induced NFkappaB transcriptional activation and IL-8 production in Caco-2 colon cancer cells.	Thalidomide	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
12485855-0	2002	Activation of the p38 MAPK and ERK1/2 pathways is required for Fas-induced IL-8 production in colonic epithelial cells.	ammonium ferrous sulfate	63-66	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
12149127-1	2002	Sphingosine 1-phosphate (S1P), a metabolite of sphingomyelin degradation, stimulates interleukin-8 (IL-8) secretion in human bronchial epithelial (Beas-2B) cells.	sphingosine 1-phosphate	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	85-98
12149127-1	2002	Sphingosine 1-phosphate (S1P), a metabolite of sphingomyelin degradation, stimulates interleukin-8 (IL-8) secretion in human bronchial epithelial (Beas-2B) cells.	sphingosine 1-phosphate	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
12208470-5	2002	The Ang II type 1 receptor (AT1R) antagonist candesartan, but not the Ang II type 2 receptor (AT2R) antagonist PD123319, significantly blocked Ang II-induced IL-8 production.	candesartan	45-56	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
12379708-7	2002	IL-8 expression by TNF-alpha was inhibited when two survival signals, nuclear factor kappaB (NF-kappaB) and phosphatidylinositol 3-kinase (PI3K)/Akt, were inhibited by a mutant form of inhibitor of NF-kappaB (IkappaB); by dominant negative (kinase-dead) Akt; or by treatment with LY 294002, an inhibitor of PI3K.	ikappab	209-216	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12208470-6	2002	Addition of fluvastatin decreased the basal and Ang II-induced IL-8 production in VSMCs in a dose (10(-8)-10(-5) mol/l)-dependent manner with a decrease in IL-8 mRNA accumulation.	Fluvastatin	12-23	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
12208470-6	2002	Addition of fluvastatin decreased the basal and Ang II-induced IL-8 production in VSMCs in a dose (10(-8)-10(-5) mol/l)-dependent manner with a decrease in IL-8 mRNA accumulation.	Fluvastatin	12-23	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
12208470-7	2002	The effect of fluvastatin on IL-8 production was completely reversed in the presence of mevalonate or geranylgeranyl-pyrophosphate, but not in the presence of squalene or farnesyl-pyrophosphate.	Fluvastatin	14-25	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
12208470-7	2002	The effect of fluvastatin on IL-8 production was completely reversed in the presence of mevalonate or geranylgeranyl-pyrophosphate, but not in the presence of squalene or farnesyl-pyrophosphate.	Mevalonic Acid	88-98	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
12208470-7	2002	The effect of fluvastatin on IL-8 production was completely reversed in the presence of mevalonate or geranylgeranyl-pyrophosphate, but not in the presence of squalene or farnesyl-pyrophosphate.	geranylgeranyl pyrophosphate	102-130	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
12208470-8	2002	Lipophilic cerivastatin also significantly decreased IL-8 production, while hydrophilic pravastatin showed no effect on IL-8 levels.	cerivastatin	11-23	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
12208470-9	2002	In conclusion, we demonstrated for the first time that Ang II increased IL-8 production and fluvastatin decreased the basal and Ang II-induced IL-8 production in human VSMCs.	Fluvastatin	92-103	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
12482390-3	2002	Using sensitive ELISAs, we found that Na(2)SO(3) induces the total (intra- and extracellular fractions) production of interleukin-12 (IL-12) and IL-8 but not TNF-alpha, IL-1alpha, or IL-4.	sodium sulfite	38-48	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
12379708-7	2002	IL-8 expression by TNF-alpha was inhibited when two survival signals, nuclear factor kappaB (NF-kappaB) and phosphatidylinositol 3-kinase (PI3K)/Akt, were inhibited by a mutant form of inhibitor of NF-kappaB (IkappaB); by dominant negative (kinase-dead) Akt; or by treatment with LY 294002, an inhibitor of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	280-289	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12464972-3	2002	Polaprezinc and zinc sulphate inhibited IL-8 production by MKN 45 cells in response to stimulation with H pylori water extract (HPE) in a dose-dependent manner from 10(-7) M to 10(-5) M. In addition, the expression of CD11b and CD18 on PMN and PMN-dependent adhesion to endothelial cells elicited by HPE was inhibited by polaprezinc and zinc sulphate in a concentration-dependent manner.	Zinc Sulfate	16-29	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
12464972-3	2002	Polaprezinc and zinc sulphate inhibited IL-8 production by MKN 45 cells in response to stimulation with H pylori water extract (HPE) in a dose-dependent manner from 10(-7) M to 10(-5) M. In addition, the expression of CD11b and CD18 on PMN and PMN-dependent adhesion to endothelial cells elicited by HPE was inhibited by polaprezinc and zinc sulphate in a concentration-dependent manner.	Water	113-118	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
12464972-3	2002	Polaprezinc and zinc sulphate inhibited IL-8 production by MKN 45 cells in response to stimulation with H pylori water extract (HPE) in a dose-dependent manner from 10(-7) M to 10(-5) M. In addition, the expression of CD11b and CD18 on PMN and PMN-dependent adhesion to endothelial cells elicited by HPE was inhibited by polaprezinc and zinc sulphate in a concentration-dependent manner.	1-(3-Methoxy-4-hydroxyphenyl)-2-[2-hydroxy-3-methoxy-5-[4-(3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane-8-yl]phenyl]-3-hydroxy-1-propanone	128-131	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
12464972-3	2002	Polaprezinc and zinc sulphate inhibited IL-8 production by MKN 45 cells in response to stimulation with H pylori water extract (HPE) in a dose-dependent manner from 10(-7) M to 10(-5) M. In addition, the expression of CD11b and CD18 on PMN and PMN-dependent adhesion to endothelial cells elicited by HPE was inhibited by polaprezinc and zinc sulphate in a concentration-dependent manner.	Zinc Sulfate	337-350	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
12482390-6	2002	Despite the fact that Na(2)SO(3) was found to increase IL-8 production, it does not induce neutrophil chemotaxis in vitro.	sodium sulfide	22-27	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
12455180-5	2002	Protec induced only a moderate production of IL-8 (1.6 fold) and IL-10 (2.3 fold) while Chizukit N caused only a moderate increase in IL-10 production (1.4 fold).	lisofylline	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
12414893-7	2002	IL-8 production by HCG was not affected by inhibitors of protein kinases A and C. In contrast, this stimulation was attenuated by D-mannose, which inhibits binding to C-type lectins.	Mannose	130-139	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12384994-6	2002	In vitro, IL-8 treated fibroblasts demonstrated an increase in GJIC by scrape loading compared to saline treated controls.	Sodium Chloride	98-104	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
12402194-3	2002	Culture supernatants of 6 wild-type strains of S. pneumoniae, shown to contain choline-binding protein A (CbpA; clades A and B), induced release of chemokine CXCL8 from the human alveolar epithelial cell line A549, whereas a CbpA deletion mutant elicited significantly reduced CXCL8 release, compared with that of its isogenic parent (P&lt;.01).	Choline	79-86	C-X-C motif chemokine ligand 8	Homo sapiens	158-163
12384994-7	2002	In vivo, IL-8 treated PVA sponges demonstrated a decrease in cell density and an increase in vascularization compared to saline controls by H&amp;E staining.	Polyvinyl Alcohol	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
12384994-7	2002	In vivo, IL-8 treated PVA sponges demonstrated a decrease in cell density and an increase in vascularization compared to saline controls by H&amp;E staining.	Sodium Chloride	121-127	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
12231210-4	2002	SP had a significant effect in that it decreased RA synovial tissue explant secretion of IL-8 (22%), GROalpha (55%), and monocyte chemotactic protein-1 (MCP-1) (42%) (P &lt; 0.05).	Sulfapyridine	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
12429722-5	2002	In addition IL-12 induces the de novo synthesis and production of IL-8 and tumor necrosis factor alpha (TNF-alpha) in a calcium- and ROM-dependent manner.	Calcium	120-127	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
12296854-7	2002	Moreover, blocking the activation of NF-kappaB by MG-132 or antisense p50 oligonucleotide transfection resulted in down-regulated expression of chemokines such as CXCL1, CXCL8, and CCL2 in BFT-stimulated HT-29 cells.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	50-56	C-X-C motif chemokine ligand 8	Homo sapiens	170-175
12296854-7	2002	Moreover, blocking the activation of NF-kappaB by MG-132 or antisense p50 oligonucleotide transfection resulted in down-regulated expression of chemokines such as CXCL1, CXCL8, and CCL2 in BFT-stimulated HT-29 cells.	Oligonucleotides	74-89	C-X-C motif chemokine ligand 8	Homo sapiens	170-175
12231210-8	2002	These data suggest that SASP may function to reduce inflammation in RA through the effects of its metabolite SP to reduce the secretion of the inflammatory chemokines IL-8, GROalpha, and MCP-1.	Sulfapyridine	26-28	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
12238566-0	2002	A green tea-derived polyphenol, epigallocatechin-3-gallate, inhibits IkappaB kinase activation and IL-8 gene expression in respiratory epithelium.	Polyphenols	20-30	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
12238566-0	2002	A green tea-derived polyphenol, epigallocatechin-3-gallate, inhibits IkappaB kinase activation and IL-8 gene expression in respiratory epithelium.	epigallocatechin gallate	32-58	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
12238566-3	2002	Herein we determined the effects of epigallocatechin-3-gallate (EGCG), a green tea-derived polyphenol, on tumor necrosis factor-alpha (TNF-alpha)-mediated expression of the IL-8 gene in A549 cells.	epigallocatechin gallate	36-62	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12238566-3	2002	Herein we determined the effects of epigallocatechin-3-gallate (EGCG), a green tea-derived polyphenol, on tumor necrosis factor-alpha (TNF-alpha)-mediated expression of the IL-8 gene in A549 cells.	epigallocatechin gallate	64-68	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12238566-3	2002	Herein we determined the effects of epigallocatechin-3-gallate (EGCG), a green tea-derived polyphenol, on tumor necrosis factor-alpha (TNF-alpha)-mediated expression of the IL-8 gene in A549 cells.	Polyphenols	91-101	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
12683216-0	2002	Modulation of interleukin-8 receptor expression by lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) in human peripheral monocytes--a preliminary study.	Tetradecanoylphorbol Acetate	80-105	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
12683216-0	2002	Modulation of interleukin-8 receptor expression by lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) in human peripheral monocytes--a preliminary study.	Tetradecanoylphorbol Acetate	107-110	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
12238566-4	2002	EGCG inhibited TNF-alpha-mediated IL-8 gene expression in a dose response manner, as measured by ELISA and Northern blot analysis.	epigallocatechin gallate	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
12683216-3	2002	We found that two very known modulators, lipopolysaccharide (LPS) in presence of homologous serum and Phorbol myristate acetate (PMA) resulted in induction of IL-8 receptor by 100-120% and 75-125% respectively within 1 h in monocytes.	Tetradecanoylphorbol Acetate	102-127	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
12238566-5	2002	This effect appears to primarily involve inhibition of IL-8 transcription because EGCG inhibited TNF-alpha-mediated activation of the IL-8 promoter in cells transiently transfected with an IL-8 promoter-luciferase reporter plasmid.	epigallocatechin gallate	82-86	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
12683216-3	2002	We found that two very known modulators, lipopolysaccharide (LPS) in presence of homologous serum and Phorbol myristate acetate (PMA) resulted in induction of IL-8 receptor by 100-120% and 75-125% respectively within 1 h in monocytes.	Tetradecanoylphorbol Acetate	129-132	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
12683216-4	2002	Based on the inhibitory effect of cycloheximide, actinomycin-D we may suggest that PMA and LPS could upregulate IL-8 receptor in monocytes through denovo protein synthesis.	Cycloheximide	34-47	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
12238566-5	2002	This effect appears to primarily involve inhibition of IL-8 transcription because EGCG inhibited TNF-alpha-mediated activation of the IL-8 promoter in cells transiently transfected with an IL-8 promoter-luciferase reporter plasmid.	epigallocatechin gallate	82-86	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
12683216-4	2002	Based on the inhibitory effect of cycloheximide, actinomycin-D we may suggest that PMA and LPS could upregulate IL-8 receptor in monocytes through denovo protein synthesis.	Dactinomycin	49-62	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
12683216-4	2002	Based on the inhibitory effect of cycloheximide, actinomycin-D we may suggest that PMA and LPS could upregulate IL-8 receptor in monocytes through denovo protein synthesis.	Tetradecanoylphorbol Acetate	83-86	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
12683216-5	2002	Prior incubation of polymixin B and anti-CD-14 antibody to the monocytes and subsequent stimulation of the cells with ser.act.LPS resulted in &gt; 90% inhibition of IL-8 binding.	Serine	118-121	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
12683216-8	2002	Chemical cross-linking of the IL-8 receptor with 125I labelled IL-8 in the ser.act.LPS and PMA stimulated cells-indicated that the signals at 59 kD were considerably increased with respect to control.	Serine	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
12683216-8	2002	Chemical cross-linking of the IL-8 receptor with 125I labelled IL-8 in the ser.act.LPS and PMA stimulated cells-indicated that the signals at 59 kD were considerably increased with respect to control.	Serine	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
12418602-2	2002	Commonly, weekly or twice monthly rinsing procedures using neutral 0.2% NaF solutions have been used in schools or institutions in areas with low fluoride concentrations in the drinking water.	Fluorides	146-154	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
12238566-5	2002	This effect appears to primarily involve inhibition of IL-8 transcription because EGCG inhibited TNF-alpha-mediated activation of the IL-8 promoter in cells transiently transfected with an IL-8 promoter-luciferase reporter plasmid.	epigallocatechin gallate	82-86	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
12683216-9	2002	A correlation between LPS and ser.act.LPS induced upregulation of IL-8 receptor expression has been shown.	Serine	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
12238566-7	2002	We conclude that EGCG is a potent inhibitor of IL-8 gene expression in vitro.	epigallocatechin gallate	17-21	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
12433059-5	2002	However, beta-glucan itself induced the production of significant amounts of IL-8 and TF.	beta-Glucans	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	77-88
12368623-7	2002	RESULTS: Clarithromycin and prednisolone each produced significant reductions in interleukin-5, interleukin-8, and granulocyte-macrophage colony-stimulating factor production.	Clarithromycin	9-23	C-X-C motif chemokine ligand 8	Homo sapiens	96-109
12364456-7	2002	Treatment of placental, amnion, and choriodecidual tissues with both 15d-PGJ(2) and troglitazone significantly reduced the release of lipopolysaccharide-stimulated IL-6, IL-8, and TNF-alpha (t test, P &lt; 0.05).	15d-pgj	69-76	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
12364456-7	2002	Treatment of placental, amnion, and choriodecidual tissues with both 15d-PGJ(2) and troglitazone significantly reduced the release of lipopolysaccharide-stimulated IL-6, IL-8, and TNF-alpha (t test, P &lt; 0.05).	Troglitazone	84-96	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
12244149-6	2002	U87 cells treated with morphine showed significant down-regulation of IL-8 gene expression, whereas expression of the IL-8 receptor CXCR2 was reciprocally up-regulated as detected by RT-PCR.	Morphine	23-31	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
12244149-7	2002	Treatment of NHAs with morphine suppressed IL-8 and macrophage-inflammatory protein-1beta gene expression, whereas expression of their receptor genes, CCR3 and CCR5, was simultaneously enhanced.	Morphine	23-31	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
12368623-7	2002	RESULTS: Clarithromycin and prednisolone each produced significant reductions in interleukin-5, interleukin-8, and granulocyte-macrophage colony-stimulating factor production.	Prednisolone	28-40	C-X-C motif chemokine ligand 8	Homo sapiens	96-109
12204776-0	2002	17Beta-estradiol inhibits the adhesion of leukocytes in TNF-alpha stimulated human endothelial cells by blocking IL-8 and MCP-1 secretion, but not its transcription.	Estradiol	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
12383538-6	2002	Monocyte chemoattractant protein-1 and interleukin-8 production was decreased by the antioxidant vitamin E in human umbilical vein endothelial cells treated with preeclamptic plasma, suggesting that the production of these cytokines may be regulated by signaling mechanisms sensitive to oxidative stress.	Vitamin E	97-106	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
12235371-0	2002	Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes.	lipoxin A4	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
12235371-0	2002	Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes.	Aspirin	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
12235371-0	2002	Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes.	lipoxin A4	33-50	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
12235371-2	2002	Recent studies indicate that peroxynitrite (ONOO(-)) may function as an intracellular signal for the production of IL-8, a potent proinflammatory cytokine in human leukocytes.	Peroxynitrous Acid	29-42	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
12235371-2	2002	Recent studies indicate that peroxynitrite (ONOO(-)) may function as an intracellular signal for the production of IL-8, a potent proinflammatory cytokine in human leukocytes.	onoo(-)	44-51	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
12235371-3	2002	In this study, we evaluated the impact of the metabolically stable analogues of LXA(4)/ATL on lipopolysaccharide (LPS)-induced ONOO(-) formation and ONOO(-)-mediated IL-8 gene expression in human leukocytes.	onoo	149-153	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
12542924-14	2002	Addition of POLY and TAU led to comparable low IL-8 gradients with concomitant low PMN transmigration.	poly	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
12542924-14	2002	Addition of POLY and TAU led to comparable low IL-8 gradients with concomitant low PMN transmigration.	taurolidine	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
12207111-0	2002	In vitro effect of fluticasone propionate on interleukin 8 production by monocytes obtained from patients affected by moderate-severe allergic asthma.	Fluticasone	19-41	C-X-C motif chemokine ligand 8	Homo sapiens	45-58
12207111-2	2002	The aim of this study was to evaluate the effect of fluticasone propionate (FP), a corticosteroid with potent anti-inflammatory activity, on the in vitro release of IL-8 by monocytes obtained from asthmatic patients.	Fluticasone	52-74	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
12216086-0	2002	Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impact on human pancreatic carcinoma cell growth by autocrine regulation.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
12216086-0	2002	Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impact on human pancreatic carcinoma cell growth by autocrine regulation.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
12216086-5	2002	RESULTS: The constitutive production of IL-8 was inhibited by curcumin at concentrations of 10-100 microM in a dose dependent manner.	Curcumin	62-70	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
12218154-8	2002	While AP-1 is involved in regulating the IL-1alpha-induced expression of IL-8, but not MCP-1, alprazolam potentiated the binding of c-Jun/c-Fos to the AP-1 oligonucleotide probe.	Alprazolam	94-104	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
12218154-8	2002	While AP-1 is involved in regulating the IL-1alpha-induced expression of IL-8, but not MCP-1, alprazolam potentiated the binding of c-Jun/c-Fos to the AP-1 oligonucleotide probe.	Oligonucleotides	156-171	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
12216086-9	2002	The investigation of expression in IL-8 receptors, CXCR1 and CXCR2, revealed that the expression of both receptors was enhanced remarkably by curcumin.	Curcumin	142-150	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
12218154-9	2002	These results show that the inhibition of IL-1alpha-mediated MCP-1 production by alprazolam is mainly due to inhibition of c-Rel/p65 and c-Rel/p50 binding to the MCP-1 promoter region, since alprazolam did not affect the IL-1alpha-mediated activation of NF-kappaB (p50/p65) or AP-1 (c-Jun/c-Fos) binding to the IL-8 promoter region.	Alprazolam	81-91	C-X-C motif chemokine ligand 8	Homo sapiens	311-315
12216086-11	2002	These results suggest that curcumin inhibits IL-8-induced receptor internalization.	Curcumin	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
12216086-12	2002	CONCLUSIONS: The authors concluded that curcumin contributed not only to the inhibition of IL-8 production but also to signal transduction through IL-8 receptors.	Curcumin	40-48	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
12216086-12	2002	CONCLUSIONS: The authors concluded that curcumin contributed not only to the inhibition of IL-8 production but also to signal transduction through IL-8 receptors.	Curcumin	40-48	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
12216086-13	2002	These data suggest that curcumin reduces numerous IL-8 bioactivities that contribute to tumor growth and carcinoma cell viability.	Curcumin	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
12216086-14	2002	From this point of view, curcumin is a potent anticancer agent that inhibits the production of proinflammatory cytokines, including IL-8, by tumor cells.	Curcumin	25-33	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
12393170-0	2002	Polycyclic aromatic hydrocarbons induce IL-8 expression through nuclear factor kappaB activation in A549 cell line.	Polycyclic Aromatic Hydrocarbons	0-32	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
12207893-4	2002	EM-X inhibited the release of IL-8 at the transcriptional level in A549 cells.	em-x	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
12393170-4	2002	Asbestos exposure and particulate air pollution have been reported to stimulate the expression of IL-8 and to induce NF-kappaB activation.	Asbestos	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
12393170-5	2002	However, it is unknown whether polycyclic aromatic hydrocarbons (PAH), mainly existed in most airborne particulates, can separately induce IL-8 expression.	Polycyclic Aromatic Hydrocarbons	31-63	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
12393170-5	2002	However, it is unknown whether polycyclic aromatic hydrocarbons (PAH), mainly existed in most airborne particulates, can separately induce IL-8 expression.	Polycyclic Aromatic Hydrocarbons	65-68	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
12393170-6	2002	In the present study, we investigated the effect of benzo(a)pyrene (B[a]P) and 1-nitropyrene (1-NP), two representative PAH, on IL-8 expression using ELISA and Northern blot analysis.	Benzo(a)pyrene	52-66	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
12393170-6	2002	In the present study, we investigated the effect of benzo(a)pyrene (B[a]P) and 1-nitropyrene (1-NP), two representative PAH, on IL-8 expression using ELISA and Northern blot analysis.	Benzo(a)pyrene	68-73	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
12393170-6	2002	In the present study, we investigated the effect of benzo(a)pyrene (B[a]P) and 1-nitropyrene (1-NP), two representative PAH, on IL-8 expression using ELISA and Northern blot analysis.	1-nitropyrene	79-92	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
12393170-6	2002	In the present study, we investigated the effect of benzo(a)pyrene (B[a]P) and 1-nitropyrene (1-NP), two representative PAH, on IL-8 expression using ELISA and Northern blot analysis.	1-nitropyrene	94-98	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
12393170-6	2002	In the present study, we investigated the effect of benzo(a)pyrene (B[a]P) and 1-nitropyrene (1-NP), two representative PAH, on IL-8 expression using ELISA and Northern blot analysis.	Polycyclic Aromatic Hydrocarbons	120-123	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
12393170-8	2002	We have assessed the effect of adenovirus-mediated overexpression of the NF-kappaB inhibitor, IkappaBalpha on PAH-induced IL-8 expression in A549 cell line.	Polycyclic Aromatic Hydrocarbons	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
12393170-12	2002	This suggests that PAH-induced IL-8 gene regulation may be mediated by NF-kappaB.	Polycyclic Aromatic Hydrocarbons	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
12393170-13	2002	These data indicate that PAH alone, either B[a]P or 1-NP, is sufficient to stimulate NF-kappaB activation and IL-8 transcription.	Polycyclic Aromatic Hydrocarbons	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
12176755-6	2002	Similarly, cross-linked MAbVLA-4 or VCAM-1 augmented Ca(2+)-mediated IL-8 secretion from THP-1 monocytes and was completely abolished by exposure to CsCl, an I(ir) blocker.	cesium chloride	149-153	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
12169581-5	2002	Furthermore, the COX substrate arachidonic acid and exogenous prostaglandin E(2) both increased IL-8 release in A549 cells.	Arachidonic Acid	31-47	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
12169581-5	2002	Furthermore, the COX substrate arachidonic acid and exogenous prostaglandin E(2) both increased IL-8 release in A549 cells.	Dinoprostone	62-80	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
12169581-0	2002	Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids.	Prostaglandins	82-93	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
12169581-2	2002	Here we tested the hypothesis that bradykinin, an inflammatory mediator and chloride secretagogue, would increase IL-8 generation in airway epithelial cells through autocrine generation of endogenous prostanoids.	Chlorides	76-84	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
12169581-2	2002	Here we tested the hypothesis that bradykinin, an inflammatory mediator and chloride secretagogue, would increase IL-8 generation in airway epithelial cells through autocrine generation of endogenous prostanoids.	Prostaglandins	200-211	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
12169581-3	2002	Bradykinin increased IL-8 generation in both a non-cystic fibrosis (A549) and cystic fibrosis epithelial cell line (CFTE29) that was inhibited by the nonselective cyclooxygenase (COX) inhibitor indomethacin and the COX-2 selective inhibitor NS-398.	Indomethacin	194-206	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
12169581-3	2002	Bradykinin increased IL-8 generation in both a non-cystic fibrosis (A549) and cystic fibrosis epithelial cell line (CFTE29) that was inhibited by the nonselective cyclooxygenase (COX) inhibitor indomethacin and the COX-2 selective inhibitor NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	241-247	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
12213589-7	2002	Both TNF-alpha and the oxidant, hydrogen peroxide (H2O2) alter histone acetylation/deacetylation, and the activation of NF-kappaB and AP-1, leading to the release of the pro-inflammatory cytokine interleukin-8 (IL-8) in human alveolar epithelial cells (A549).	Hydrogen Peroxide	32-49	C-X-C motif chemokine ligand 8	Homo sapiens	196-209
12213589-7	2002	Both TNF-alpha and the oxidant, hydrogen peroxide (H2O2) alter histone acetylation/deacetylation, and the activation of NF-kappaB and AP-1, leading to the release of the pro-inflammatory cytokine interleukin-8 (IL-8) in human alveolar epithelial cells (A549).	Hydrogen Peroxide	32-49	C-X-C motif chemokine ligand 8	Homo sapiens	211-215
12213589-7	2002	Both TNF-alpha and the oxidant, hydrogen peroxide (H2O2) alter histone acetylation/deacetylation, and the activation of NF-kappaB and AP-1, leading to the release of the pro-inflammatory cytokine interleukin-8 (IL-8) in human alveolar epithelial cells (A549).	Hydrogen Peroxide	51-55	C-X-C motif chemokine ligand 8	Homo sapiens	196-209
12213589-7	2002	Both TNF-alpha and the oxidant, hydrogen peroxide (H2O2) alter histone acetylation/deacetylation, and the activation of NF-kappaB and AP-1, leading to the release of the pro-inflammatory cytokine interleukin-8 (IL-8) in human alveolar epithelial cells (A549).	Hydrogen Peroxide	51-55	C-X-C motif chemokine ligand 8	Homo sapiens	211-215
12213589-8	2002	Pharmacological inhibition of HDAC leads to the increased HAT activity, AP-1 and NF-kappaB activation, and IL-8 release by H2O2 or TNF-alpha treatments.	Hydrogen Peroxide	123-127	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
12213594-4	2002	Moreover, preincubation of HUVEC with 10 ng/mL TcdB-10463 reduced TNF-alpha-related expression of interleukin-8 (IL-8), TNF-receptor associated factor-2 (TRAF2), and human inhibitor of apoptosis protein 1 (hIAP1)-mRNA.	trimethylaminocarboxyldihydroboran	47-51	C-X-C motif chemokine ligand 8	Homo sapiens	98-111
12213594-4	2002	Moreover, preincubation of HUVEC with 10 ng/mL TcdB-10463 reduced TNF-alpha-related expression of interleukin-8 (IL-8), TNF-receptor associated factor-2 (TRAF2), and human inhibitor of apoptosis protein 1 (hIAP1)-mRNA.	trimethylaminocarboxyldihydroboran	47-51	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
12176910-9	2002	The removal of TLR2 lipopeptide components from LPS by phenol re-extraction substantially reduced both the IL-8 and superoxide response of the stimulated neutrophils, indicating that, unlike monocytes, the neutrophil response is preferentially directed to TLR2 ligands.	Phenol	55-61	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
12193739-4	2002	HMC-1-induced IL-8 release was significantly reduced by the tryptase inhibitors GW-45 and GW-58 (90 and 87%, respectively, at an optimal concentration) but not by anti-stem cell factor, anti-TNF-alpha, or anti-IFN-gamma neutralizing Abs or by the antihistamine drugs pyrilamine and cimetidine.	Cimetidine	282-292	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
12607189-6	2002	RESULTS: Histamine increased the production of IL-1, IL-6 and IL-8, and ICAM-1 expression.	Histamine	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
12607189-8	2002	The antiH-1, emedastine, significantly reduced H-induced production of IL-1, IL-6 and IL-8, while azelastine reduced only IL-1.	emedastine	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
12193739-4	2002	HMC-1-induced IL-8 release was significantly reduced by the tryptase inhibitors GW-45 and GW-58 (90 and 87%, respectively, at an optimal concentration) but not by anti-stem cell factor, anti-TNF-alpha, or anti-IFN-gamma neutralizing Abs or by the antihistamine drugs pyrilamine and cimetidine.	glycyltryptophan	80-82	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
12353856-0	2002	Local release of human neutrophil lipocalin (HNL), IL-8, and TNF-alpha is decreased as response to topical prednisolone treatment in distal ulcerative colitis and proctitis.	Prednisolone	107-119	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
12193669-9	2002	Dexamethasone inhibited IL-8 secretion by 34 +/- 8% in children and by 41 +/- 3% in adults but had no effect on infant PBMC.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
12225373-5	2002	Stimulation with zymosan and LPS readily induced interleukin (IL)-6 and IL-8 cytokine production in the placenta cultures, whereas TLR2 and TLR4 mRNA and protein expression remained at the same high level as in unstimulated explants.	Zymosan	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
12193739-4	2002	HMC-1-induced IL-8 release was significantly reduced by the tryptase inhibitors GW-45 and GW-58 (90 and 87%, respectively, at an optimal concentration) but not by anti-stem cell factor, anti-TNF-alpha, or anti-IFN-gamma neutralizing Abs or by the antihistamine drugs pyrilamine and cimetidine.	gw-58	90-95	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
12193739-4	2002	HMC-1-induced IL-8 release was significantly reduced by the tryptase inhibitors GW-45 and GW-58 (90 and 87%, respectively, at an optimal concentration) but not by anti-stem cell factor, anti-TNF-alpha, or anti-IFN-gamma neutralizing Abs or by the antihistamine drugs pyrilamine and cimetidine.	Pyrilamine	267-277	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
12193669-11	2002	However, the inhibitory effects of steroids on IL-8 secretion are absent in infants, which may partly explain why they develop more severe bronchiolitis, and why steroid therapy is unsuccessful in clinical practice.	Steroids	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
12193669-11	2002	However, the inhibitory effects of steroids on IL-8 secretion are absent in infants, which may partly explain why they develop more severe bronchiolitis, and why steroid therapy is unsuccessful in clinical practice.	Steroids	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
12201814-8	2002	injections of prostaglandin 9 days apart, IL-8 gene expression at oestrus was significantly lower than it was at natural oestrus.	Prostaglandins	14-27	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
12176048-1	2002	Human osteoblast-like cells (hOB) stimulated by monosodium urate monohydrate (MSUM) or calcium pyrophosphate dihydrate (CPPD) microcrystals produce the neutrophil chemoattractant IL-8.	Uric Acid	48-76	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
12208513-1	2002	In this report we explored the effects of proteasome inhibitors (MG132, aLLN, lactacystin and MG262) on interleukin-8 (IL-8) induction.	MG 262	94-99	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
12208513-3	2002	The stimulating effects on IL-8 promoter and AP-1 were reduced by N-acetylcysteine, glutathione, diphenyleneiodonium, rotenone and antimycin A.	Acetylcysteine	66-82	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
12208513-3	2002	The stimulating effects on IL-8 promoter and AP-1 were reduced by N-acetylcysteine, glutathione, diphenyleneiodonium, rotenone and antimycin A.	Glutathione	84-95	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
12208513-3	2002	The stimulating effects on IL-8 promoter and AP-1 were reduced by N-acetylcysteine, glutathione, diphenyleneiodonium, rotenone and antimycin A.	diphenyleneiodonium	97-116	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
12208513-3	2002	The stimulating effects on IL-8 promoter and AP-1 were reduced by N-acetylcysteine, glutathione, diphenyleneiodonium, rotenone and antimycin A.	Rotenone	118-126	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
12208513-3	2002	The stimulating effects on IL-8 promoter and AP-1 were reduced by N-acetylcysteine, glutathione, diphenyleneiodonium, rotenone and antimycin A.	Antimycin A	131-142	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
12208513-5	2002	These results suggest that ROS production by proteasome inhibitors leads to AP-1 activation, which in the absence of NF-kappa B activation still transactivates IL-8 gene expression.	Reactive Oxygen Species	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
12215676-5	2002	In the present study, we found that Na(2)SO(3) (0.01-10 mM) induces tyrosine phosphorylation events and interleukin-8 production in human epithelial lung A549 cells.	sodium sulfite	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	104-117
12215678-7	2002	There were differences between the aliphatic hydrocarbons with respect to their effects on IL-8 release.	Hydrocarbons	45-57	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
12215678-8	2002	IL-8 concentration was increased significantly by 3- to 10-fold, with the highest increase found after exposure to hydrocarbons in the C9-C13 range.	Hydrocarbons	115-127	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12077146-6	2002	On the other hand, cells expressing all single, double, or triple histidine-substituted CXCR1 demonstrated high affinity binding to interleukin 8 in the presence and absence of metal ions.	Histidine	66-75	C-X-C motif chemokine ligand 8	Homo sapiens	132-145
12208513-1	2002	In this report we explored the effects of proteasome inhibitors (MG132, aLLN, lactacystin and MG262) on interleukin-8 (IL-8) induction.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	65-70	C-X-C motif chemokine ligand 8	Homo sapiens	104-117
12208513-1	2002	In this report we explored the effects of proteasome inhibitors (MG132, aLLN, lactacystin and MG262) on interleukin-8 (IL-8) induction.	allosamine	72-76	C-X-C motif chemokine ligand 8	Homo sapiens	104-117
12208513-1	2002	In this report we explored the effects of proteasome inhibitors (MG132, aLLN, lactacystin and MG262) on interleukin-8 (IL-8) induction.	allosamine	72-76	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
12208513-1	2002	In this report we explored the effects of proteasome inhibitors (MG132, aLLN, lactacystin and MG262) on interleukin-8 (IL-8) induction.	lactacystin	78-89	C-X-C motif chemokine ligand 8	Homo sapiens	104-117
12208513-1	2002	In this report we explored the effects of proteasome inhibitors (MG132, aLLN, lactacystin and MG262) on interleukin-8 (IL-8) induction.	lactacystin	78-89	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
12208513-1	2002	In this report we explored the effects of proteasome inhibitors (MG132, aLLN, lactacystin and MG262) on interleukin-8 (IL-8) induction.	MG 262	94-99	C-X-C motif chemokine ligand 8	Homo sapiens	104-117
12176048-1	2002	Human osteoblast-like cells (hOB) stimulated by monosodium urate monohydrate (MSUM) or calcium pyrophosphate dihydrate (CPPD) microcrystals produce the neutrophil chemoattractant IL-8.	Uric Acid	78-82	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
12176048-1	2002	Human osteoblast-like cells (hOB) stimulated by monosodium urate monohydrate (MSUM) or calcium pyrophosphate dihydrate (CPPD) microcrystals produce the neutrophil chemoattractant IL-8.	Calcium Pyrophosphate	87-118	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
12176048-1	2002	Human osteoblast-like cells (hOB) stimulated by monosodium urate monohydrate (MSUM) or calcium pyrophosphate dihydrate (CPPD) microcrystals produce the neutrophil chemoattractant IL-8.	Calcium Pyrophosphate	120-124	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
12297109-5	2002	Using reverse transcriptase-polymerase chain reaction (RT-PCR), immunoprecipitation and western blot analysis, we report that the early signalling events triggered by the hIL-17 involved tyrosyl phosphorylation of proteins and increased the levels of IL-6, IL-8 and MCP-1 in a dose-dependent manner.	cyclo(tyrosyl-tyrosyl)	187-194	C-X-C motif chemokine ligand 8	Homo sapiens	257-261
12151316-1	2002	In this study, we investigated the effects of proteasome inhibibors (MG132 and lactacystin) on interleukin (IL)-8 induction.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	69-74	C-X-C motif chemokine ligand 8	Homo sapiens	95-113
12039947-0	2002	Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells.	sphingosine 1-phosphate	30-53	C-X-C motif chemokine ligand 8	Homo sapiens	64-77
12039947-7	2002	Inhibition of 12-O-tetradecanoyl-phorbol-13-acetate-stimulated IL-8 production by 1-butanol further strengthened this observation.	Tetradecanoylphorbol Acetate	14-51	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
12039947-7	2002	Inhibition of 12-O-tetradecanoyl-phorbol-13-acetate-stimulated IL-8 production by 1-butanol further strengthened this observation.	1-Butanol	82-91	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
18968742-7	2002	Potential interference from dissolved silica and Fe(III) is eliminated by the addition of NaF to the sample.	Silicon Dioxide	38-44	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
18968742-7	2002	Potential interference from dissolved silica and Fe(III) is eliminated by the addition of NaF to the sample.	ferric sulfate	49-56	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
12107048-5	2002	The suppressive effect of amiloride on endotoxin-induced IL-8 production was associated with a decreased accumulation of IL-8 mRNA.	Amiloride	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
12107048-5	2002	The suppressive effect of amiloride on endotoxin-induced IL-8 production was associated with a decreased accumulation of IL-8 mRNA.	Amiloride	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
12151316-1	2002	In this study, we investigated the effects of proteasome inhibibors (MG132 and lactacystin) on interleukin (IL)-8 induction.	lactacystin	79-90	C-X-C motif chemokine ligand 8	Homo sapiens	95-113
12151316-2	2002	In human epithelial A549 cells, MG132 and lactacystin induced IL-8 release within the range of 0.1-30 microM.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	32-37	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
12151316-2	2002	In human epithelial A549 cells, MG132 and lactacystin induced IL-8 release within the range of 0.1-30 microM.	lactacystin	42-53	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
12151316-3	2002	The effect of MG132 resulted from IL-8 gene transcription and was blocked by PD 98059, but was unaffected by GF109203X, Ro 31-8220, or SB 203580.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	14-19	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
12151316-4	2002	Mutational analysis of the 5" flanking region of the IL-8 gene revealed that activator protein (AP)-1-binding element, but not that element responsive to nuclear factor (NF)-IL-6 or NF-kappaB, was necessary for MG132 stimulation.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	211-216	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
12151316-7	2002	In addition, activations of the IL-8 gene and AP-1 by MG132 and lactacystin were inhibited by GSH and NAC.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	54-59	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
12151316-7	2002	In addition, activations of the IL-8 gene and AP-1 by MG132 and lactacystin were inhibited by GSH and NAC.	lactacystin	64-75	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
12151316-7	2002	In addition, activations of the IL-8 gene and AP-1 by MG132 and lactacystin were inhibited by GSH and NAC.	Glutathione	94-97	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
12151316-8	2002	Herein we present a novel action of proteasome inhibitors, possibly through ROS production, of targeting the upstream signaling molecules, ERK and JNK, which leads to AP-1 activation and IL-8 gene expression.	ros	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
12169830-6	2002	The 50% inhibitory concentrations by DEX, BET, and HC for IL-8 release were 3.4 +/- (SE) 1.6 x 10(-9), 1.8 +/- 7.4 x 10(-8), and 1.8 +/- 0.5 x 10(-7) M, respectively.	Dexamethasone	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
12151344-0	2002	Expression of interleukin-8, heme oxygenase-1 and vascular endothelial growth factor in DLD-1 colon carcinoma cells exposed to pyrrolidine dithiocarbamate.	pyrrolidine dithiocarbamic acid	127-154	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
12169830-6	2002	The 50% inhibitory concentrations by DEX, BET, and HC for IL-8 release were 3.4 +/- (SE) 1.6 x 10(-9), 1.8 +/- 7.4 x 10(-8), and 1.8 +/- 0.5 x 10(-7) M, respectively.	Betamethasone	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
12139725-0	2002	Simultaneous induction of matrix metalloproteinase-9 and interleukin 8 by all-trans retinoic acid in human PL-21 and NB4 myeloid leukaemia cells.	2-octenal	78-83	C-X-C motif chemokine ligand 8	Homo sapiens	57-70
12139725-0	2002	Simultaneous induction of matrix metalloproteinase-9 and interleukin 8 by all-trans retinoic acid in human PL-21 and NB4 myeloid leukaemia cells.	Tretinoin	84-97	C-X-C motif chemokine ligand 8	Homo sapiens	57-70
12139725-8	2002	ATRA can induce interleukin 8 (IL-8) in APL cells.	Tretinoin	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	16-29
12139725-8	2002	ATRA can induce interleukin 8 (IL-8) in APL cells.	Tretinoin	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
12139725-9	2002	IL-8, chemokine for neutrophils and a potent inducer of MMP-9, was also induced by ATRA in PL-21 cells.	Tretinoin	83-87	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12169830-1	2002	The objective of this study was to determine the doses of dexamethasone (DEX), betamethasone (BET), and hydrocortisone (HC) that effectively inhibit the release of two potent proinflammatory chemokines, interleukin 8 (IL-8) and macrophage inflammatory protein alpha (MIP), from polymorphonuclear neutrophils (PMNs) of the newborn.	Dexamethasone	58-71	C-X-C motif chemokine ligand 8	Homo sapiens	203-216
12169830-1	2002	The objective of this study was to determine the doses of dexamethasone (DEX), betamethasone (BET), and hydrocortisone (HC) that effectively inhibit the release of two potent proinflammatory chemokines, interleukin 8 (IL-8) and macrophage inflammatory protein alpha (MIP), from polymorphonuclear neutrophils (PMNs) of the newborn.	Dexamethasone	58-71	C-X-C motif chemokine ligand 8	Homo sapiens	218-222
12169830-1	2002	The objective of this study was to determine the doses of dexamethasone (DEX), betamethasone (BET), and hydrocortisone (HC) that effectively inhibit the release of two potent proinflammatory chemokines, interleukin 8 (IL-8) and macrophage inflammatory protein alpha (MIP), from polymorphonuclear neutrophils (PMNs) of the newborn.	Dexamethasone	73-76	C-X-C motif chemokine ligand 8	Homo sapiens	203-216
12169830-1	2002	The objective of this study was to determine the doses of dexamethasone (DEX), betamethasone (BET), and hydrocortisone (HC) that effectively inhibit the release of two potent proinflammatory chemokines, interleukin 8 (IL-8) and macrophage inflammatory protein alpha (MIP), from polymorphonuclear neutrophils (PMNs) of the newborn.	Dexamethasone	73-76	C-X-C motif chemokine ligand 8	Homo sapiens	218-222
12169830-1	2002	The objective of this study was to determine the doses of dexamethasone (DEX), betamethasone (BET), and hydrocortisone (HC) that effectively inhibit the release of two potent proinflammatory chemokines, interleukin 8 (IL-8) and macrophage inflammatory protein alpha (MIP), from polymorphonuclear neutrophils (PMNs) of the newborn.	Betamethasone	79-92	C-X-C motif chemokine ligand 8	Homo sapiens	203-216
12169830-1	2002	The objective of this study was to determine the doses of dexamethasone (DEX), betamethasone (BET), and hydrocortisone (HC) that effectively inhibit the release of two potent proinflammatory chemokines, interleukin 8 (IL-8) and macrophage inflammatory protein alpha (MIP), from polymorphonuclear neutrophils (PMNs) of the newborn.	Betamethasone	79-92	C-X-C motif chemokine ligand 8	Homo sapiens	218-222
12169830-1	2002	The objective of this study was to determine the doses of dexamethasone (DEX), betamethasone (BET), and hydrocortisone (HC) that effectively inhibit the release of two potent proinflammatory chemokines, interleukin 8 (IL-8) and macrophage inflammatory protein alpha (MIP), from polymorphonuclear neutrophils (PMNs) of the newborn.	Betamethasone	94-97	C-X-C motif chemokine ligand 8	Homo sapiens	203-216
12169830-1	2002	The objective of this study was to determine the doses of dexamethasone (DEX), betamethasone (BET), and hydrocortisone (HC) that effectively inhibit the release of two potent proinflammatory chemokines, interleukin 8 (IL-8) and macrophage inflammatory protein alpha (MIP), from polymorphonuclear neutrophils (PMNs) of the newborn.	Betamethasone	94-97	C-X-C motif chemokine ligand 8	Homo sapiens	218-222
12169830-1	2002	The objective of this study was to determine the doses of dexamethasone (DEX), betamethasone (BET), and hydrocortisone (HC) that effectively inhibit the release of two potent proinflammatory chemokines, interleukin 8 (IL-8) and macrophage inflammatory protein alpha (MIP), from polymorphonuclear neutrophils (PMNs) of the newborn.	Hydrocortisone	104-118	C-X-C motif chemokine ligand 8	Homo sapiens	203-216
12169830-1	2002	The objective of this study was to determine the doses of dexamethasone (DEX), betamethasone (BET), and hydrocortisone (HC) that effectively inhibit the release of two potent proinflammatory chemokines, interleukin 8 (IL-8) and macrophage inflammatory protein alpha (MIP), from polymorphonuclear neutrophils (PMNs) of the newborn.	Hydrocortisone	104-118	C-X-C motif chemokine ligand 8	Homo sapiens	218-222
12169830-4	2002	Maximal inhibitions of IL-8 release by BET, DEX, and HC were 97, 91, and 91%, respectively.	Betamethasone	39-42	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
12169830-4	2002	Maximal inhibitions of IL-8 release by BET, DEX, and HC were 97, 91, and 91%, respectively.	Dexamethasone	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
12139725-12	2002	These observations suggest that ATRA can induce both MMP-9 and IL-8, but IL-8 is not involved in ATRA-induced MMP-9 expression.	Tretinoin	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
12139725-13	2002	As MMP-9 can truncate and activate IL-8, simultaneous induction of MMP-9 and IL-8 by ATRA could activate leucocytes excessively, causing the hyper-inflammatory events in retinoic acid syndrome.	Tretinoin	85-89	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
12139725-13	2002	As MMP-9 can truncate and activate IL-8, simultaneous induction of MMP-9 and IL-8 by ATRA could activate leucocytes excessively, causing the hyper-inflammatory events in retinoic acid syndrome.	Tretinoin	85-89	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
12151344-3	2002	Here we report that pyrrolidine dithiocarbamate (PDTC) not only augmented tumor necrosis factor-alpha-induced release of IL-8, but also mediated IL-8 expression as a single stimulus.	pyrrolidine dithiocarbamic acid	20-47	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
12151344-3	2002	Here we report that pyrrolidine dithiocarbamate (PDTC) not only augmented tumor necrosis factor-alpha-induced release of IL-8, but also mediated IL-8 expression as a single stimulus.	pyrrolidine dithiocarbamic acid	20-47	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
12151344-3	2002	Here we report that pyrrolidine dithiocarbamate (PDTC) not only augmented tumor necrosis factor-alpha-induced release of IL-8, but also mediated IL-8 expression as a single stimulus.	pyrrolidine dithiocarbamic acid	49-53	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
12151344-3	2002	Here we report that pyrrolidine dithiocarbamate (PDTC) not only augmented tumor necrosis factor-alpha-induced release of IL-8, but also mediated IL-8 expression as a single stimulus.	pyrrolidine dithiocarbamic acid	49-53	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
12154423-9	2002	MEASUREMENTS AND MAIN RESULTS: In the control and tranexamic acid groups, tumor necrosis factor-alpha, IL-6, and IL-10 secretion by whole blood cell cultures were rapidly decreased, whereas IL-8 secretion was unaffected.	Tranexamic Acid	50-65	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
12171898-5	2002	IL-8 has been reported to augment the progression of some human tumors; thus, we used a human IL-8 antibody, ABXIL8, in combination with anti-EGFR, ABXEGFR, to inhibit the metastasis of MDA231 tumors.	abxil8	109-115	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12171898-5	2002	IL-8 has been reported to augment the progression of some human tumors; thus, we used a human IL-8 antibody, ABXIL8, in combination with anti-EGFR, ABXEGFR, to inhibit the metastasis of MDA231 tumors.	abxil8	109-115	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
12165085-7	2002	T-HPMC and P-HPMC constitutively expressed IL-6 and IL-8 at both protein and mRNA level.	t-hpmc	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
12165085-7	2002	T-HPMC and P-HPMC constitutively expressed IL-6 and IL-8 at both protein and mRNA level.	p-hpmc	11-17	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
12165085-11	2002	These data indicate that (1) T-HPMC lines mimic the morphological and functional features of P-HPMC, (2) P-HPMC and T-HPMC constituitively produce IL-6 and IL-8, which is enhanced by hIL-1beta and hTNF-alpha and (3) HPMC in vivo may participate in the pathogenesis of benign and malignant gynaecological disease.	t-hpmc	29-35	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
12165085-11	2002	These data indicate that (1) T-HPMC lines mimic the morphological and functional features of P-HPMC, (2) P-HPMC and T-HPMC constituitively produce IL-6 and IL-8, which is enhanced by hIL-1beta and hTNF-alpha and (3) HPMC in vivo may participate in the pathogenesis of benign and malignant gynaecological disease.	hydroxypropylmethylcellulose-lactose matrix	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
12165085-11	2002	These data indicate that (1) T-HPMC lines mimic the morphological and functional features of P-HPMC, (2) P-HPMC and T-HPMC constituitively produce IL-6 and IL-8, which is enhanced by hIL-1beta and hTNF-alpha and (3) HPMC in vivo may participate in the pathogenesis of benign and malignant gynaecological disease.	t-hpmc	116-122	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
12165085-11	2002	These data indicate that (1) T-HPMC lines mimic the morphological and functional features of P-HPMC, (2) P-HPMC and T-HPMC constituitively produce IL-6 and IL-8, which is enhanced by hIL-1beta and hTNF-alpha and (3) HPMC in vivo may participate in the pathogenesis of benign and malignant gynaecological disease.	hydroxypropylmethylcellulose-lactose matrix	95-99	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
12165097-4	2002	Incubation of FLS with a synthetic PPARgamma ligand, troglitazone, inhibited endogenous production of TNF-alpha, IL-6 and IL-8, as well as matrix metalloprotease-3 (MMP-3), without inducing apoptosis of the cells.	Troglitazone	53-65	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
12088610-5	2002	Additionally, P. acnes-induced IL-8 secretion was inhibited by roxithromycin, a macrolide antibiotic, and its inhibitory effect seemed to be partially associated with the inhibition of P. acnes-induced NF-kappaB activation.	Roxithromycin	63-76	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
12088610-5	2002	Additionally, P. acnes-induced IL-8 secretion was inhibited by roxithromycin, a macrolide antibiotic, and its inhibitory effect seemed to be partially associated with the inhibition of P. acnes-induced NF-kappaB activation.	Macrolides	80-89	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
12173800-10	2002	Pulmonary TNF-alpha, IL-beta, and IL-8 concentrations were attenuated in the ceftazidime group compared with those in the placebo group (p &lt; 0.001, p = 0.02, and p = 0.003).	Ceftazidime	77-88	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
12161534-11	2002	IL-8 decreased apoptosis rate in endometrial stromal cells as evaluated by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labeling assay.	deoxyuridine triphosphate	122-147	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12133975-5	2002	PMA plus A23187 or IgE plus anti-IgE induced the production of IL-8 and GM-CSF in supernatants of HMC-1 cells and IL-4 and IL-6 in supernatants of KU812 cells.	Calcimycin	9-15	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
12220349-6	2002	After daily fluoride release was measured for 60 days, samples were refluoridated in 1000-ppm sodium fluoride (NaF) solutions (pH 6.6) for 10 min and fluoride release was measured daily for a total of 5 days.	Sodium Fluoride	94-109	C-X-C motif chemokine ligand 8	Homo sapiens	111-114
12220349-11	2002	Sample exposures to 1000 ppm NaF solution increased the 24-h fluoride release from all fluoride-containing materials.	Fluorides	61-69	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
12220349-11	2002	Sample exposures to 1000 ppm NaF solution increased the 24-h fluoride release from all fluoride-containing materials.	Fluorides	87-95	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
12117995-3	2002	The inhibitor genistein decreased NF-kappaB nuclear translocation and IL-8 gene transcription in addition to acting on posttranscriptional processing.	Genistein	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
12107097-3	2002	The human melanoma cells A375SM (high IL-8 producer) and TXM-13 (intermediate IL-8 producer) were injected subcutaneously into nude mice, which were then treated with ABX-IL8 (1 mg/3 times weekly, i.p., for 3 weeks).	CHEMBL369125	167-170	C-X-C motif chemokine ligand 8	Homo sapiens	171-174
11986301-8	2002	sTLR2 partially attenuated the iPGN-induced NF-kappaB activation in TLR2-transfected HEK 293 cells and the iPGN-induced IL-8 secretion in U937 cells.	ipgn	107-111	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
12115542-11	2002	Finally, RA decreased the ability of tumor-activated macrophages to secrete IL-8 and VEGF.	Tretinoin	9-11	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
11978798-0	2002	A novel pathway for nickel-induced interleukin-8 expression.	Nickel	20-26	C-X-C motif chemokine ligand 8	Homo sapiens	35-48
11978798-3	2002	Therefore, cell culture experiments with BEAS-2B human airway epithelial cells were conducted to test the hypothesis that exposure to non-cytotoxic levels of Ni3S2 induces expression of inflammatory cytokines such as interleukin-8 (IL-8).	ni3s2	158-163	C-X-C motif chemokine ligand 8	Homo sapiens	217-230
11978798-3	2002	Therefore, cell culture experiments with BEAS-2B human airway epithelial cells were conducted to test the hypothesis that exposure to non-cytotoxic levels of Ni3S2 induces expression of inflammatory cytokines such as interleukin-8 (IL-8).	ni3s2	158-163	C-X-C motif chemokine ligand 8	Homo sapiens	232-236
11978798-4	2002	Exposure to Ni3S2 for 48 h was required to significantly increase IL-8 protein levels.	ni3s2	12-17	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
11978798-7	2002	Transfection with truncated IL-8 promoter constructs linked to the luciferase gene demonstrated that nickel-induced IL-8 transcription required -272 bp of the promoter relative to the transcriptional start site.	Nickel	101-107	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
11978798-7	2002	Transfection with truncated IL-8 promoter constructs linked to the luciferase gene demonstrated that nickel-induced IL-8 transcription required -272 bp of the promoter relative to the transcriptional start site.	Nickel	101-107	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
11978798-9	2002	Transfection with a dominant negative AP-1 construct or mutation of the AP-1, GATA, or C/EBP sites in the -272-bp IL-8 promoter construct blocked induction by nickel.	gata	78-82	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
11978798-9	2002	Transfection with a dominant negative AP-1 construct or mutation of the AP-1, GATA, or C/EBP sites in the -272-bp IL-8 promoter construct blocked induction by nickel.	Nickel	159-165	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
11978798-10	2002	Inhibiting ERK, phosphatidylinositol 3-kinase, but not p38 kinase, diacylglycerol kinase, or hypoxia-inducible factor-1alpha, attenuated nickel induction of IL-8.	Nickel	137-143	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
11978798-11	2002	These studies indicate that nickel induced IL-8 transcription through a novel pathway that requires both AP-1 and non-traditional transcription factors.	Nickel	28-34	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
12060565-4	2002	1) Bleomycin-treated THP-1 cells increased tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, and IL-1beta production in dose- and time-dependent patterns, as we have observed with SP-A.	Bleomycin	3-12	C-X-C motif chemokine ligand 8	Homo sapiens	78-96
12091253-6	2002	The blockade of p38 with the pharmacologic inhibitor SB203580 abrogated IL-8 production by cell stretching, and an inhibitor of the p44/42 pathway, PD98059, partially inhibited the IL-8 response.	SB 203580	53-61	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
12091250-2	2002	As cigarette smoke (CS) and epidermal growth factor (EGF) both cause release of interleukin-8 (IL-8) from epithelial cells in vitro, we investigated whether autocrine ligands for the EGF receptor (EGFR) are involved in this proinflammatory response to CS.	Cesium	20-22	C-X-C motif chemokine ligand 8	Homo sapiens	80-93
12091253-6	2002	The blockade of p38 with the pharmacologic inhibitor SB203580 abrogated IL-8 production by cell stretching, and an inhibitor of the p44/42 pathway, PD98059, partially inhibited the IL-8 response.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	148-155	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
12091250-2	2002	As cigarette smoke (CS) and epidermal growth factor (EGF) both cause release of interleukin-8 (IL-8) from epithelial cells in vitro, we investigated whether autocrine ligands for the EGF receptor (EGFR) are involved in this proinflammatory response to CS.	Cesium	20-22	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
12091250-7	2002	Furthermore, ~ 45% of CS-induced IL-8 release was inhibited by a neutralising anti-EGFR.	Cesium	22-24	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
12115021-14	2002	Furosemide exhibited an anti-inflammatory effect through inhibition of production and release of cytokines interleukin (IL)-6, IL-8, and tumor necrosis factor-alpha from peripheral mononuclear cells, which may have a beneficial effect on local inflamed tissue imbalance in the ratio of different cytokines, thus improving the sensitivity of target cells to endogenous glucocorticosteroids.	Furosemide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	127-164
12091253-7	2002	A nonspecific tyrosine kinase inhibitor, genistein, also blocked the stretch-induced IL-8 production.	Genistein	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
12117719-6	2002	Attenuation of the C pneumoniae-induced activation of NF-kappaB by aspirin also reduced the secretion of interleukin-6 and interleukin-8, indicating efficient inhibition of NF-kappaB gene expression.	Aspirin	67-74	C-X-C motif chemokine ligand 8	Homo sapiens	123-136
12126020-0	2002	Exposure to 200 ppm of methanol increases the concentrations of interleukin-1beta and interleukin-8 in nasal secretions of healthy volunteers.	Methanol	23-31	C-X-C motif chemokine ligand 8	Homo sapiens	86-99
12126020-7	2002	The median concentrations of IL-8 and IL-1beta were significantly elevated after exposure to 200 ppm of methanol as compared to exposure to 20 ppm (IL-1beta, 21.4 versus 8.3 pg/mL, p = .001; IL-8, 424 versus 356 pg/mL, p = .02).	Methanol	104-112	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
12126020-7	2002	The median concentrations of IL-8 and IL-1beta were significantly elevated after exposure to 200 ppm of methanol as compared to exposure to 20 ppm (IL-1beta, 21.4 versus 8.3 pg/mL, p = .001; IL-8, 424 versus 356 pg/mL, p = .02).	Methanol	104-112	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
12126020-9	2002	Both IL-8 and IL-1beta proved to be sensitive indicators for subclinical irritating effects of methanol in vivo.	Methanol	95-103	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
12117737-0	2002	Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients.	Simvastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	59-72
12161102-0	2002	Green tea polyphenol blocks h(2)o(2)-induced interleukin-8 production from human alveolar epithelial cells.	Polyphenols	10-20	C-X-C motif chemokine ligand 8	Homo sapiens	45-58
12117737-4	2002	METHODS AND RESULTS: In this study, we asked whether simvastatin can influence in vitro and in vivo production of the proinflammatory cytokines interleukin (IL)-6, IL-8, and monocyte chemoattractant protein-1.	Simvastatin	53-64	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
12117737-7	2002	Furthermore, simvastatin decreased the expression of IL-6, IL-8, and monocyte chemoattractant protein-1 mRNA in peripheral blood mononuclear cells.	Simvastatin	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
12199625-0	2002	The effect of high molecular weight dextran sulfate on the production of interleukin-8 in monocyte cell culture.	Dextran Sulfate	36-51	C-X-C motif chemokine ligand 8	Homo sapiens	73-86
12199625-5	2002	We hereby postulate that HMDS induces IL-8 biosynthesis in monocyte cell culture.	hexamethylsilazane	25-29	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
12117643-4	2002	Independently, RV16, NO2, and O3 rapidly increased release of the inflammatory cytokine interleukin-8 through oxidant-dependent mechanisms.	Nitrogen Dioxide	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
12070216-4	2002	This increase in PKC is observed with 15 min of HDE treatment, and kinase activity reaches peak activity by 1-2 h of HDE treatment before returning to baseline PKC levels between 6 and 24 h. The classic PKC inhibitor, calphostin C, blocks HDE-stimulated PKC activity and associated IL-8 and IL-6 release.	calphostin C	218-230	C-X-C motif chemokine ligand 8	Homo sapiens	282-286
12100898-6	2002	RESULTS: Significantly elevated percentages of BAL neutrophils and IL-8 levels were found at the pre-clinical stage of BOS, on average 151 +/- 164 days and 307 +/- 266 days, respectively, before diagnosis of BOS.	N-[4-(Aminosulfonyl)phenyl]-2-Mercaptobenzamide	119-122	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
12056817-2	2002	We found a high level of IL-8 production in SK-N-MC human primitive neuroectodermal tumor cells transfected with the human RET gene (SK-N-MC (RET) cells) in response to glial cell line-derived neurotrophic factor (GDNF) stimulation.	sk-n-mc	44-51	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
12056817-2	2002	We found a high level of IL-8 production in SK-N-MC human primitive neuroectodermal tumor cells transfected with the human RET gene (SK-N-MC (RET) cells) in response to glial cell line-derived neurotrophic factor (GDNF) stimulation.	sk-n-mc	133-140	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
12056817-5	2002	The results showed that a MEK1 inhibitor, PD98059, a p38MAPK inhibitor, SB202190, and a protein kinase C (PKC) inhibitor, Calphostin C, markedly decreased the IL-8 secretion from SK-N-MC (RET) cells at 24 h after GDNF stimulation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	42-49	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
12056817-5	2002	The results showed that a MEK1 inhibitor, PD98059, a p38MAPK inhibitor, SB202190, and a protein kinase C (PKC) inhibitor, Calphostin C, markedly decreased the IL-8 secretion from SK-N-MC (RET) cells at 24 h after GDNF stimulation.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	72-80	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
12056817-5	2002	The results showed that a MEK1 inhibitor, PD98059, a p38MAPK inhibitor, SB202190, and a protein kinase C (PKC) inhibitor, Calphostin C, markedly decreased the IL-8 secretion from SK-N-MC (RET) cells at 24 h after GDNF stimulation.	calphostin C	122-134	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
12056817-5	2002	The results showed that a MEK1 inhibitor, PD98059, a p38MAPK inhibitor, SB202190, and a protein kinase C (PKC) inhibitor, Calphostin C, markedly decreased the IL-8 secretion from SK-N-MC (RET) cells at 24 h after GDNF stimulation.	sk-n-mc	179-186	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
12115500-9	2002	Here, we report on a new autocrine function of secreted interleukin-8 and the intracellular signal transduction leading to the regulation of cytosolic calcium and to a migratory tumor cell phenotype.	Calcium	151-158	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
12100025-0	2002	Anti-CD45 isoform antibodies enhance phagocytosis and gene expression of IL-8 and TNF-alpha in human neutrophils by differential suppression on protein tyrosine phosphorylation and p56lck tyrosine kinase.	Tyrosine	152-160	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
12087060-7	2002	In the in vitro study, a cooperative suppressive effect of NE (10(-6) M to 10(-8) M) and cortisol (10(-6) M and 10(-7) M) on secretion of IL-8 and TNF from primary early culture mixed RA synoviocytes was observed.	Hydrocortisone	89-97	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
12060853-4	2002	Incubation with hypericin, a natural photosensitizer increased IL-8 significantly but only in HK1 cells.	hypericin	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
12060853-7	2002	It is interesting that PDT which is known to upregulate IL-8 transcription via reactive oxygen species and activate the IL-10 promoter did not alter IL-8 levels in either of the NPC cell lines nor induced the production of IL-10.	Reactive Oxygen Species	79-102	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
12161102-0	2002	Green tea polyphenol blocks h(2)o(2)-induced interleukin-8 production from human alveolar epithelial cells.	Hydrogen Peroxide	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	45-58
12161102-2	2002	Reactive oxygen species may stimulate the production of neutrophil chemotactic factors such as interleukin-8 (IL-8), from alveolar epithelial cells, causing recruitment and activation of neutrophils in the reperfused tissue.	Reactive Oxygen Species	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	95-108
12161102-2	2002	Reactive oxygen species may stimulate the production of neutrophil chemotactic factors such as interleukin-8 (IL-8), from alveolar epithelial cells, causing recruitment and activation of neutrophils in the reperfused tissue.	Reactive Oxygen Species	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
12161102-4	2002	In the present study, we found that green tea polyphenol significantly inhibited IL-8 production induced by hydrogen peroxide (H(2)O(2)) in human lung alveolar epithelial cells (A549 line).	Polyphenols	46-56	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
12161102-4	2002	In the present study, we found that green tea polyphenol significantly inhibited IL-8 production induced by hydrogen peroxide (H(2)O(2)) in human lung alveolar epithelial cells (A549 line).	Hydrogen Peroxide	108-125	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
12161102-7	2002	We speculate that green tea polyphenol may inhibit H(2)O(2)-induced IL-8 production from A549 cells through inactivation of JNK and p38.	Polyphenols	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
12161102-7	2002	We speculate that green tea polyphenol may inhibit H(2)O(2)-induced IL-8 production from A549 cells through inactivation of JNK and p38.	Hydrogen Peroxide	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
12469754-0	2002	Effect of application time of APF and NaF gels on microhardness and fluoride uptake of in vitro enamel caries.	Fluorides	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
11997318-6	2002	Furthermore, an antisense oligodeoxyribonucleotide targeted against TRAF6 mRNA blunted p38 and SAPK/JNK but not ERK1/2 MAPK activities, as well as IL-8 and MCP-1 production, arguing that TRAF6 is an upstream activator.	Oligodeoxyribonucleotides	26-50	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
12045128-7	2002	Nanomolar concentrations of LXA4 and LXB4 inhibited the IL-8 released by peripheral blood mononuclear cells from the two groups of patients with asthma: a maximal inhibition of 29.4% (p &lt; 0.01) was observed for patients with mild asthma, and 41.5% inhibition (p &lt; 0.001) for patients with severe asthma at 1 nM and 100 nM LXA4 concentrations, respectively.	lipoxin A4	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
12011031-2	2002	Consequently, gingipains-R reduced lipopolysaccharide-induced interleukin-8 production by HGF, indicating that gingipains-R inhibited CD14-dependent HGF activation and are involved in immune evasion by the bacterium in periodontal tissues.	gingipains-r reduced lipopolysaccharide	14-53	C-X-C motif chemokine ligand 8	Homo sapiens	62-75
12045128-7	2002	Nanomolar concentrations of LXA4 and LXB4 inhibited the IL-8 released by peripheral blood mononuclear cells from the two groups of patients with asthma: a maximal inhibition of 29.4% (p &lt; 0.01) was observed for patients with mild asthma, and 41.5% inhibition (p &lt; 0.001) for patients with severe asthma at 1 nM and 100 nM LXA4 concentrations, respectively.	lipoxin B4	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
12079131-0	2002	Human vascular endothelial cells express pattern recognition receptors for fungal glucans which stimulates nuclear factor kappaB activation and interleukin 8 production.	Glucans	82-89	C-X-C motif chemokine ligand 8	Homo sapiens	144-157
12079131-8	2002	Glucan (1 microg/mL) stimulated VEC nuclear factor kappaB nuclear binding activity and Interleukin 8 expression--but not that of vascular endothelial growth factor--in a time-dependent manner.	Glucans	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	87-100
12166720-2	2002	The purpose of this study was to evaluate the cytotoxic effects of sodium fluoride (NaF) on three different cell lines and the antibacterial potency on Streptococcus sobrinus.	Sodium Fluoride	67-82	C-X-C motif chemokine ligand 8	Homo sapiens	84-87
12132790-13	2002	This is against the hypothesis that nicotine exerts a direct pro-inflammatory action via interleukin-1beta and interleukin-8.	Nicotine	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	111-124
11992543-8	2002	MEK inhibitor U0126 preferentially blocked AP-1 activity and expression of both IL-8 and VEGF, while PI3K inhibitor LY-294002 or a dominant negative inhibitor-kappaB preferentially blocked NF-kappaB activation and expression of IL-8 but not VEGF.	U 0126	14-19	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
11920660-4	2002	The results showed that fucan, dextran derivatives, and heparin differentially (1) triggered interleukin-1alpha, tumor necrosis factor alpha, interleukin-6, and interleukin-8 production by monocytes in a dose-dependent manner, (2) modulated cytokine production by LPS-stimulated monocytes, and (3) specifically inhibited the binding of biotinylated LPS to monocyte membranes.	fucan	24-29	C-X-C motif chemokine ligand 8	Homo sapiens	161-174
11920660-4	2002	The results showed that fucan, dextran derivatives, and heparin differentially (1) triggered interleukin-1alpha, tumor necrosis factor alpha, interleukin-6, and interleukin-8 production by monocytes in a dose-dependent manner, (2) modulated cytokine production by LPS-stimulated monocytes, and (3) specifically inhibited the binding of biotinylated LPS to monocyte membranes.	Dextrans	31-38	C-X-C motif chemokine ligand 8	Homo sapiens	161-174
11920660-4	2002	The results showed that fucan, dextran derivatives, and heparin differentially (1) triggered interleukin-1alpha, tumor necrosis factor alpha, interleukin-6, and interleukin-8 production by monocytes in a dose-dependent manner, (2) modulated cytokine production by LPS-stimulated monocytes, and (3) specifically inhibited the binding of biotinylated LPS to monocyte membranes.	Heparin	56-63	C-X-C motif chemokine ligand 8	Homo sapiens	161-174
12011031-2	2002	Consequently, gingipains-R reduced lipopolysaccharide-induced interleukin-8 production by HGF, indicating that gingipains-R inhibited CD14-dependent HGF activation and are involved in immune evasion by the bacterium in periodontal tissues.	gingipains-r	14-26	C-X-C motif chemokine ligand 8	Homo sapiens	62-75
12051749-2	2002	In this report we employed CXCL8((3-73))K11R as a template to generate CXCL8/IL-8 analogues with antagonist activities, using site-directed mutagenesis to introduce conservative amino acid substitutions into the first turn within the molecule"s beta-pleated sheet region (G31P, P32G) and, in association with these, into the putative receptor-recognition site (T12S, H13F, F17S).	k11r	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	71-76
12023021-4	2002	By prednisolone or phorbol myristate acetate treatment, EC-SOD levels were correlated negatively with levels of IL-6 and IL-8.	Prednisolone	3-15	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
12023021-4	2002	By prednisolone or phorbol myristate acetate treatment, EC-SOD levels were correlated negatively with levels of IL-6 and IL-8.	Tetradecanoylphorbol Acetate	19-44	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
12166728-1	2002	A new route has been devised, leading to the production of phosphorus thiotrihalides, SPX3 where X = F, Br and I by an on-line process using phosphorus thiotrichloride, SPCl3 as starting compound gassed over the following heated salts NaF, KBr and KI at 530, 800 and 440 degrees C, respectively.	phosphorus thiotrihalides	59-84	C-X-C motif chemokine ligand 8	Homo sapiens	235-238
12126643-8	2002	SB203580, a specific P38 MAPK inhibitor, partially blocked IL-1beta induction of IL-8 mRNA, IL-8 promoter activity, and AP-1 nuclear extract binding but not NF-kappaB DNA binding.	SB 203580	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
12126643-8	2002	SB203580, a specific P38 MAPK inhibitor, partially blocked IL-1beta induction of IL-8 mRNA, IL-8 promoter activity, and AP-1 nuclear extract binding but not NF-kappaB DNA binding.	SB 203580	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
12016098-5	2002	Induced sputum inflammatory cells, neutrophils, interleukin-8, myeloperoxidase, and lactoferrin were all significantly reduced by about 22% by theophylline.	Theophylline	143-155	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
12016098-6	2002	Neutrophils from subjects treated with theophylline showed reduced chemotaxis to N-formyl-met-leu-phe (approximately 28%) and interleukin-8 (approximately 60%).	Theophylline	39-51	C-X-C motif chemokine ligand 8	Homo sapiens	126-139
12051749-2	2002	In this report we employed CXCL8((3-73))K11R as a template to generate CXCL8/IL-8 analogues with antagonist activities, using site-directed mutagenesis to introduce conservative amino acid substitutions into the first turn within the molecule"s beta-pleated sheet region (G31P, P32G) and, in association with these, into the putative receptor-recognition site (T12S, H13F, F17S).	k11r	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
12051749-2	2002	In this report we employed CXCL8((3-73))K11R as a template to generate CXCL8/IL-8 analogues with antagonist activities, using site-directed mutagenesis to introduce conservative amino acid substitutions into the first turn within the molecule"s beta-pleated sheet region (G31P, P32G) and, in association with these, into the putative receptor-recognition site (T12S, H13F, F17S).	k11r	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	27-32
12010777-0	2002	Caprylic acid and medium-chain triglycerides inhibit IL-8 gene transcription in Caco-2 cells: comparison with the potent histone deacetylase inhibitor trichostatin A.	octanoic acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
11891214-6	2002	Selective MAP kinase kinase (MEK)1/2 inhibitors, PD98059 and U0126, inhibited, in a dose-dependent manner, ML-1-induced expression of IL-6 and IL-8.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	49-56	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
11891214-6	2002	Selective MAP kinase kinase (MEK)1/2 inhibitors, PD98059 and U0126, inhibited, in a dose-dependent manner, ML-1-induced expression of IL-6 and IL-8.	U 0126	61-66	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
12051749-3	2002	We then examined their impact on the analogues" biological activities and found that a G31P substitution rendered CXCL8((3-73))K11R a high affinity antagonist of CXCL8/IL-8.	k11r	127-131	C-X-C motif chemokine ligand 8	Homo sapiens	114-119
12051749-3	2002	We then examined their impact on the analogues" biological activities and found that a G31P substitution rendered CXCL8((3-73))K11R a high affinity antagonist of CXCL8/IL-8.	k11r	127-131	C-X-C motif chemokine ligand 8	Homo sapiens	162-167
12051749-3	2002	We then examined their impact on the analogues" biological activities and found that a G31P substitution rendered CXCL8((3-73))K11R a high affinity antagonist of CXCL8/IL-8.	k11r	127-131	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
12062638-12	2002	Finally, generation of reactive oxygen species (which occurs during alcohol metabolism) and products of lipid peroxidation induce production of cytokines, such as TNF and IL-8.	Reactive Oxygen Species	23-46	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
12062638-12	2002	Finally, generation of reactive oxygen species (which occurs during alcohol metabolism) and products of lipid peroxidation induce production of cytokines, such as TNF and IL-8.	Alcohols	68-75	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
11996908-1	2002	The fluoroaluminate (AlF(4)(-)) ion and sodium fluoride (NaF) have previously been shown to be bone cell mitogens.	Sodium Fluoride	40-55	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
11996908-5	2002	NaF, AlF(3), and AlF(4)(-), each at 50-100 micromol/L, increased [3H]thymidine incorporation in TE85 cells.	Tritium	66-68	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
11996908-5	2002	NaF, AlF(3), and AlF(4)(-), each at 50-100 micromol/L, increased [3H]thymidine incorporation in TE85 cells.	Thymidine	69-78	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
12010777-0	2002	Caprylic acid and medium-chain triglycerides inhibit IL-8 gene transcription in Caco-2 cells: comparison with the potent histone deacetylase inhibitor trichostatin A.	Triglycerides	31-44	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
12010777-4	2002	In this study we examined whether caprylic acid, one of the MCFAs, and MCT suppress IL-8 secretion by differentiated Caco-2 cells.	octanoic acid	34-47	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
12010777-6	2002	We found for the first time that caprylic acid and MCT suppress IL-8 secretion by Caco-2 cells at the transcriptional level when precultured together for 24 h. We also tried to clarify the mechanism of IL-8 gene inhibition by examining the activation of NF-kappaB and other transcription factors by electrophoretic mobility shift assay (EMSA), and found that caprylic acid did not modulate their activation.	octanoic acid	33-46	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
12010777-6	2002	We found for the first time that caprylic acid and MCT suppress IL-8 secretion by Caco-2 cells at the transcriptional level when precultured together for 24 h. We also tried to clarify the mechanism of IL-8 gene inhibition by examining the activation of NF-kappaB and other transcription factors by electrophoretic mobility shift assay (EMSA), and found that caprylic acid did not modulate their activation.	octanoic acid	33-46	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
12010777-8	2002	The result of dual-luciferase assay using Caco-2 cells transfected with IL-8 promoter/luciferase reporter plasmid revealed that caprylic acid inhibited the activation of IL-8 promoter.	octanoic acid	128-141	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
12010777-8	2002	The result of dual-luciferase assay using Caco-2 cells transfected with IL-8 promoter/luciferase reporter plasmid revealed that caprylic acid inhibited the activation of IL-8 promoter.	octanoic acid	128-141	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
12010777-13	2002	TSA rapidly induced H4 acetylation in IL-8 promoter chromatin, whereas caprylic acid did not.	trichostatin A	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
12010777-14	2002	These results suggest that the inhibition of IL-8 gene transcription induced by caprylic acid and TSA does not necessarily require the marked suppression of transcription factors, and the mechanism of inhibition of IL-8 gene transcription may be different between caprylic acid and TSA.	octanoic acid	80-93	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
12010777-14	2002	These results suggest that the inhibition of IL-8 gene transcription induced by caprylic acid and TSA does not necessarily require the marked suppression of transcription factors, and the mechanism of inhibition of IL-8 gene transcription may be different between caprylic acid and TSA.	trichostatin A	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
12010777-14	2002	These results suggest that the inhibition of IL-8 gene transcription induced by caprylic acid and TSA does not necessarily require the marked suppression of transcription factors, and the mechanism of inhibition of IL-8 gene transcription may be different between caprylic acid and TSA.	octanoic acid	264-277	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
12010777-14	2002	These results suggest that the inhibition of IL-8 gene transcription induced by caprylic acid and TSA does not necessarily require the marked suppression of transcription factors, and the mechanism of inhibition of IL-8 gene transcription may be different between caprylic acid and TSA.	octanoic acid	264-277	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
12010777-14	2002	These results suggest that the inhibition of IL-8 gene transcription induced by caprylic acid and TSA does not necessarily require the marked suppression of transcription factors, and the mechanism of inhibition of IL-8 gene transcription may be different between caprylic acid and TSA.	trichostatin A	282-285	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
11953364-7	2002	Pretreatment of cells with the highly specific MEK1/2 inhibitor U0126, the p38 inhibitor SB203580, and/or the proteasome inhibitor ALLN led to inhibition of the IL-8 secretion induced in EHEC-infected T84 cells.	U 0126	64-69	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
11953364-7	2002	Pretreatment of cells with the highly specific MEK1/2 inhibitor U0126, the p38 inhibitor SB203580, and/or the proteasome inhibitor ALLN led to inhibition of the IL-8 secretion induced in EHEC-infected T84 cells.	SB 203580	89-97	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
11953371-7	2002	IL-8 slightly stimulated butyric acid- or Fas-induced Jurkat-cell apoptosis in a dose-dependent manner, although a low dose of IL-8 had a mildly inhibitory effect on apoptosis.	Butyric Acid	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
11953371-7	2002	IL-8 slightly stimulated butyric acid- or Fas-induced Jurkat-cell apoptosis in a dose-dependent manner, although a low dose of IL-8 had a mildly inhibitory effect on apoptosis.	ammonium ferrous sulfate	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12003967-0	2002	Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-kappa B transcription factors.	Clarithromycin	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	53-66
12003967-6	2002	A luciferase reporter gene assay with plasmids containing a serially deleted IL-8 promoter fragment showed that both the activator protein-1 (AP-1) and/or the nuclear factor-kappa B (NF-kapp aB) binding sequences were responsible for the LPS and clarithromycin responsiveness of the IL-8 promoter.	Clarithromycin	246-260	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
12003967-9	2002	Our results indicate that clarithromycin modified inflammation by sup-pressing IL-8 production and that clarithromycin may affect the expression of other genes through AP-1 and NF-kappa B.	Clarithromycin	26-40	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
12015158-5	2002	Furthermore, berry polyphenols also reduced TNFalpha induced up-regulation of various inflammatory mediators (IL-8, MCP-1 and ICAM-1) involved in the recruitment of leukocytes to sites of damage or inflammation along the endothelium.	Polyphenols	19-30	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
11971003-4	2002	IL-8-stimulated neutrophil adhesion to fibrinogen was blocked 50% by the MAPK/extracellular signal-related kinase-activating enzyme inhibitor PD098059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	142-150	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
11971003-5	2002	Adhesion was blocked approximately 75% by inhibition of the phosphatidylinositol-3 kinase (PI3K) pathway with LY294002, supporting that activation of both MAPK and PI3K may play a role in IL-8-dependent inside-out signals that activate Mac-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
11971003-6	2002	Activation of MAPK was inhibited in IL-8-stimulated cells in the presence of PI3K inhibitors LY294002 or wortmannin, supporting a model in which PI3K is upstream of MAPK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
11971003-6	2002	Activation of MAPK was inhibited in IL-8-stimulated cells in the presence of PI3K inhibitors LY294002 or wortmannin, supporting a model in which PI3K is upstream of MAPK.	Wortmannin	105-115	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
11971003-7	2002	IL-8-stimulated neutrophil adhesion was inhibited 50% by bisindolylmaleimide-I, implicating protein kinase C (PKC) in the intracellular signaling from the IL-8R to Mac-1.	bisindolylmaleimide I	57-78	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12038622-0	2002	Titanium particles induce the immediate early stress responsive chemokines IL-8 and MCP-1 in osteoblasts.	Titanium	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
12038622-3	2002	In this study, we now demonstrate that Ti particles can rapidly induce the chemotactic cytokines interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1), two immediate early stress responsive chemokines important for the activation and chemotaxis of neutrophils and macrophages, respectively.	Titanium	39-41	C-X-C motif chemokine ligand 8	Homo sapiens	97-110
12038622-3	2002	In this study, we now demonstrate that Ti particles can rapidly induce the chemotactic cytokines interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1), two immediate early stress responsive chemokines important for the activation and chemotaxis of neutrophils and macrophages, respectively.	Titanium	39-41	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
12038622-6	2002	Actinomycin D, a potent RNA polymerase II inhibitor, blocked the Ti particle induction of IL-8 and MCP-1 mRNA expression, whereas cycloheximide, which inhibits protein synthesis, failed to inhibit chemokine gene expression suggesting Ti particles directly target activation of chemokine gene transcription.	Dactinomycin	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
12038622-8	2002	Taken together, these data demonstrate that Ti particles can activate transcription of the stress responsive chemokine genes IL-8 and MCP-1 in human osteoblasts.	Titanium	44-46	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
12162465-7	2002	In airway epithelial cells, sphingosine-1-phosphate and PA-induced IL-8 secretion and ERKI/2 phosphorylation is regulated by PA.	sphingosine 1-phosphate	28-51	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
12197272-8	2002	DISCUSSION: The decrease in IL-8 serum levels observed in exposed workers might suggest an immunosuppressive effect of occupational exposure to very low doses of inorganic mercury.	Mercury	172-179	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
12162440-11	2002	This study shows that the oxidant H2O2 and the pro-inflammatory mediator, TNF-a induce histone acetylation which is associated with decreased GSH levels and increased AP-1 and NF-kappaB activation leading to enhanced proinflammatory IL-8 release in alveolar epithelial cells.	Hydrogen Peroxide	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	233-237
12162440-10	2002	Both H2O2 and TNF-alpha significantly increased IL-8 release, which was further enhanced by pre-treatment of A549 cells with TSA compared to the individual treatments.	Hydrogen Peroxide	5-9	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
12162465-7	2002	In airway epithelial cells, sphingosine-1-phosphate and PA-induced IL-8 secretion and ERKI/2 phosphorylation is regulated by PA.	Phosphatidic Acids	56-58	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
12162440-10	2002	Both H2O2 and TNF-alpha significantly increased IL-8 release, which was further enhanced by pre-treatment of A549 cells with TSA compared to the individual treatments.	trichostatin A	125-128	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
12162440-11	2002	This study shows that the oxidant H2O2 and the pro-inflammatory mediator, TNF-a induce histone acetylation which is associated with decreased GSH levels and increased AP-1 and NF-kappaB activation leading to enhanced proinflammatory IL-8 release in alveolar epithelial cells.	Glutathione	142-145	C-X-C motif chemokine ligand 8	Homo sapiens	233-237
12162465-7	2002	In airway epithelial cells, sphingosine-1-phosphate and PA-induced IL-8 secretion and ERKI/2 phosphorylation is regulated by PA.	Phosphatidic Acids	125-127	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
11897597-1	2002	A 14-member macrolide was found to inhibit interleukin-8 (IL-8) synthesis in lipopolysaccharide-stimulated neutrophils but did not accelerate apoptosis in activated neutrophils.	-member macrolide	4-21	C-X-C motif chemokine ligand 8	Homo sapiens	43-56
12096924-0	2002	Glutamine decreases interleukin-8 and interleukin-6 but not nitric oxide and prostaglandins e(2) production by human gut in-vitro.	Glutamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	20-33
12096924-8	2002	RESULTS: Glutamine decreased IL-8 and IL-6 in-vitro production: 63 [2-173] vs 100 [19-177] and 37 [5-489] vs 100 [33-431], both P&lt;0.05.	Glutamine	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
12096924-9	2002	IL-8 mRNA level also decreased in biopsies cultured with 5 mM glutamine: 26 [13-142] vs 92 [34-215], P&lt;0.05.	Glutamine	62-71	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
11943329-4	2002	Both hr IL-8 and the culture supernatant from PBMC treated with EWD yielded a distinct band, molecular weight of 6-8kDa, in sodium-dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) with 15% loading gel.	Sodium Dodecyl Sulfate	124-146	C-X-C motif chemokine ligand 8	Homo sapiens	8-12
11943329-4	2002	Both hr IL-8 and the culture supernatant from PBMC treated with EWD yielded a distinct band, molecular weight of 6-8kDa, in sodium-dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) with 15% loading gel.	polyacrylamide	147-161	C-X-C motif chemokine ligand 8	Homo sapiens	8-12
11943329-4	2002	Both hr IL-8 and the culture supernatant from PBMC treated with EWD yielded a distinct band, molecular weight of 6-8kDa, in sodium-dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) with 15% loading gel.	Sodium Dodecyl Sulfate	183-186	C-X-C motif chemokine ligand 8	Homo sapiens	8-12
11943329-9	2002	A single protein band with 6-8kDa was shown in both the eluate and hr IL-8 when analyzed by SDS-PAGE and Western blotting using anti-hr IL-8 pAb, suggesting that the chemotactic factor for feline PMN is IL-8, 6-8kDa, produced by PBMC treated with EWD.	Sodium Dodecyl Sulfate	92-95	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
11943329-11	2002	The eluate under these conditions also showed a distinct band in molecular weight of 6-8kDa in SDS-PAGE and Western blotting and was very active in chemotactic activity of PMN.IL-8 mRNA gene expression on feline PBMC was analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR) assay using a series of oligonucleotides, each 22 mer, derived from feline IL-8.	Sodium Dodecyl Sulfate	95-98	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
11897597-1	2002	A 14-member macrolide was found to inhibit interleukin-8 (IL-8) synthesis in lipopolysaccharide-stimulated neutrophils but did not accelerate apoptosis in activated neutrophils.	-member macrolide	4-21	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
11950713-6	2002	(2) During folic acid treatment, normalization of homocysteine levels was accompanied by a marked reduction in oxidized low density lipoprotein-stimulated release of CXC chemokines (ie, GROalpha, ENA-78, and interleukin-8) and CC chemokines (ie, monocyte chemoattractant peptide-1 and RANTES) in peripheral blood mononuclear cells from these individuals.	Folic Acid	11-21	C-X-C motif chemokine ligand 8	Homo sapiens	208-221
12034025-0	2002	Regulation of constitutive and induced NF-kappaB activation in malignant melanoma cells by capsaicin modulates interleukin-8 production and cell proliferation.	Capsaicin	91-100	C-X-C motif chemokine ligand 8	Homo sapiens	111-124
11950713-6	2002	(2) During folic acid treatment, normalization of homocysteine levels was accompanied by a marked reduction in oxidized low density lipoprotein-stimulated release of CXC chemokines (ie, GROalpha, ENA-78, and interleukin-8) and CC chemokines (ie, monocyte chemoattractant peptide-1 and RANTES) in peripheral blood mononuclear cells from these individuals.	Homocysteine	50-62	C-X-C motif chemokine ligand 8	Homo sapiens	208-221
11895948-5	2002	Lactoferrin strongly inhibited the interaction of radiolabeled IL-8 to immobilized heparin, whereas a lactoferrin variant lacking the amino acid residues essential for heparin binding was not inhibitory.	Heparin	83-90	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
11927646-0	2002	Ambient pCO2 modulates intracellular pH, intracellular oxidant generation, and interleukin-8 secretion in human neutrophils.	pco2	8-12	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
11927646-4	2002	Further, hypo- and hypercarbia increase and decrease, respectively, the release of IL-8 from LPS-stimulated cells; both effects are attenuated by the carbonic anhydrase inhibitor, acetazolamide.	Acetazolamide	180-193	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
11910356-0	2002	Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation.	Reactive Oxygen Species	87-101	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
11910356-3	2002	METHODS: NF-kappaB activation and IL-8 release in response to toxin A were correlated with reactive oxygen intermediate (ROI) generation and ATP production in HT-29 monolayers or HT-29 cells exposed to ethidium bromide (EB) to inhibit mitochondrial function.	reactive oxygen intermediate	91-119	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
11910356-3	2002	METHODS: NF-kappaB activation and IL-8 release in response to toxin A were correlated with reactive oxygen intermediate (ROI) generation and ATP production in HT-29 monolayers or HT-29 cells exposed to ethidium bromide (EB) to inhibit mitochondrial function.	ROI	121-124	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
11910356-3	2002	METHODS: NF-kappaB activation and IL-8 release in response to toxin A were correlated with reactive oxygen intermediate (ROI) generation and ATP production in HT-29 monolayers or HT-29 cells exposed to ethidium bromide (EB) to inhibit mitochondrial function.	Ethidium	202-218	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
11989791-5	2002	We demonstrate that blockade of the p42/p44 MAPK signaling pathway by the inhibitor PD98059 suppresses IL-8-mediated PMNL chemotaxis.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	84-91	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
11907118-6	2002	A monomeric form of IL-8, N-methyl-leucine 25 IL-8, was not retained as long in lungs as recombinant human IL-8, indicating that dimerization of IL-8 is a mechanism that increases the local concentration and prolongs the retention of (125)I-labeled IL-8 in lungs.	n-methyl-leucine	26-42	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
12034025-6	2002	Further, downregulation of IL-8 expression in capsaicin-treated melanoma cells resulted in inhibition of in vitro cell proliferation.	Capsaicin	46-55	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
12034025-2	2002	Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells.	Capsaicin	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
12034025-2	2002	Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells.	Capsaicin	23-55	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
12034025-3	2002	The inhibition of IL-8 expression was dependent on the concentration of capsaicin and duration of treatment.	Capsaicin	72-81	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
12034025-5	2002	Treatment of melanoma cells with capsaicin inhibited activation of constitutive and IL-1beta-induced NF-kappaB, but not AP-1, leading to inhibition of IL-8 expression.	Capsaicin	33-42	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
11912286-7	2002	The immunoreactive levels of endometrial IL-8 and MCP-1 were up-regulated by the administration of progesterone during the receptive phase of the cycle.	Progesterone	99-111	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
11950021-11	2002	No NSAID showed significant effects on basal and IL-1beta stimulated IL-8 production, except CELE and IBUP, which slightly increased basal IL-8 production.	Celecoxib	93-97	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
11950021-11	2002	No NSAID showed significant effects on basal and IL-1beta stimulated IL-8 production, except CELE and IBUP, which slightly increased basal IL-8 production.	Ibuprofen	102-106	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
11950021-8	2002	A large amount (43%) of the IL-8 produced was stored in the alginate beads, whereas almost all IL-6 production (94%) was released in the culture supernatant.	Alginates	60-68	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
11884459-7	2002	Suppression of IL-8/CXCL8 was abrogated in the presence of anti-CCR3 mAb, pertussis toxin, and wortmannin, indicating it was mediated by the CCR3 receptor, G(i) proteins, and phosphatidylinositol 3-kinase signaling.	Wortmannin	95-105	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
11909816-5	2002	The nonselective adenosine agonist 5"-N-ethylcarboxamidoadenosine (NECA) increased expression of interleukin-8 (IL-8), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) in HMEC-1, but had no effect in HUVECs.	Adenosine	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	97-110
11909816-5	2002	The nonselective adenosine agonist 5"-N-ethylcarboxamidoadenosine (NECA) increased expression of interleukin-8 (IL-8), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) in HMEC-1, but had no effect in HUVECs.	Adenosine	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
11909816-5	2002	The nonselective adenosine agonist 5"-N-ethylcarboxamidoadenosine (NECA) increased expression of interleukin-8 (IL-8), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) in HMEC-1, but had no effect in HUVECs.	Adenosine-5'-(N-ethylcarboxamide)	35-65	C-X-C motif chemokine ligand 8	Homo sapiens	97-110
11909816-5	2002	The nonselective adenosine agonist 5"-N-ethylcarboxamidoadenosine (NECA) increased expression of interleukin-8 (IL-8), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) in HMEC-1, but had no effect in HUVECs.	Adenosine-5'-(N-ethylcarboxamide)	35-65	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
11909816-5	2002	The nonselective adenosine agonist 5"-N-ethylcarboxamidoadenosine (NECA) increased expression of interleukin-8 (IL-8), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) in HMEC-1, but had no effect in HUVECs.	Adenosine-5'-(N-ethylcarboxamide)	67-71	C-X-C motif chemokine ligand 8	Homo sapiens	97-110
11909816-5	2002	The nonselective adenosine agonist 5"-N-ethylcarboxamidoadenosine (NECA) increased expression of interleukin-8 (IL-8), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) in HMEC-1, but had no effect in HUVECs.	Adenosine-5'-(N-ethylcarboxamide)	67-71	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
11958950-0	2002	Nacystelyn inhibits oxidant-mediated interleukin-8 expression and NF-kappaB nuclear binding in alveolar epithelial cells.	N-acetylcysteine lysinate	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
11958950-3	2002	NAL (5 mM) enhanced intracellular glutathione (GSH) after 4 h and abolished H(2)O(2)-induced IL-8 release from A549 cells.	N-acetylcysteine lysinate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
11958950-5	2002	NAL also abolished the transcriptional activation of IL-8 in an IL-8-chloramphenicol acetyl transferase (CAT) reporter system, transfected into A549 cells.	N-acetylcysteine lysinate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
11958950-5	2002	NAL also abolished the transcriptional activation of IL-8 in an IL-8-chloramphenicol acetyl transferase (CAT) reporter system, transfected into A549 cells.	N-acetylcysteine lysinate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
11884459-7	2002	Suppression of IL-8/CXCL8 was abrogated in the presence of anti-CCR3 mAb, pertussis toxin, and wortmannin, indicating it was mediated by the CCR3 receptor, G(i) proteins, and phosphatidylinositol 3-kinase signaling.	Wortmannin	95-105	C-X-C motif chemokine ligand 8	Homo sapiens	20-25
11877327-4	2002	Pre-stimulation of cells with adenosine 5"-triphosphate (ATP) revealed a substantial Ca(2+) signalling component mediated by IL-8 (E(max)=83 +/- 8% of maximal ATP response, pEC(50) of IL-8 response=9.7 +/- 0.1).	Adenosine Triphosphate	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
12027404-13	2002	In summary, while both IL-6 and IL-8 are overexpressed in paclitaxel resistant cell lines, only IL-6 has the potential to contribute directly to paclitaxel and doxorubicin resistance in U-2OS.	Paclitaxel	58-68	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
11949939-11	2002	More convincingly, IL-8 antisense oligonucleotide treatment decreases IL-8 production by endometrial cells as well as cell proliferation when compared to non-sense oligonucleotide treatment.	Oligonucleotides	34-49	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
11949939-11	2002	More convincingly, IL-8 antisense oligonucleotide treatment decreases IL-8 production by endometrial cells as well as cell proliferation when compared to non-sense oligonucleotide treatment.	Oligonucleotides	34-49	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
11949939-11	2002	More convincingly, IL-8 antisense oligonucleotide treatment decreases IL-8 production by endometrial cells as well as cell proliferation when compared to non-sense oligonucleotide treatment.	Oligonucleotides	164-179	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
11949939-12	2002	The addition of IL-8 reverses the inhibitory effect of IL-8 antisense oligonucleotides on cell proliferation.	Oligonucleotides	70-86	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
11949939-12	2002	The addition of IL-8 reverses the inhibitory effect of IL-8 antisense oligonucleotides on cell proliferation.	Oligonucleotides	70-86	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
11877327-4	2002	Pre-stimulation of cells with adenosine 5"-triphosphate (ATP) revealed a substantial Ca(2+) signalling component mediated by IL-8 (E(max)=83 +/- 8% of maximal ATP response, pEC(50) of IL-8 response=9.7 +/- 0.1).	Adenosine Triphosphate	30-55	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
11877327-4	2002	Pre-stimulation of cells with adenosine 5"-triphosphate (ATP) revealed a substantial Ca(2+) signalling component mediated by IL-8 (E(max)=83 +/- 8% of maximal ATP response, pEC(50) of IL-8 response=9.7 +/- 0.1).	Adenosine Triphosphate	30-55	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
11877327-4	2002	Pre-stimulation of cells with adenosine 5"-triphosphate (ATP) revealed a substantial Ca(2+) signalling component mediated by IL-8 (E(max)=83 +/- 8% of maximal ATP response, pEC(50) of IL-8 response=9.7 +/- 0.1).	Adenosine Triphosphate	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
11756416-0	2002	Lithium induces NF-kappa B activation and interleukin-8 production in human intestinal epithelial cells.	Lithium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	42-55
11756416-5	2002	This lithium-induced up-regulation of NF-kappa B and MAP kinase activation was associated with an enhancement of interleukin-8 mRNA accumulation as well as an increase in interleukin-8 protein release.	Lithium	5-12	C-X-C motif chemokine ligand 8	Homo sapiens	113-126
11756416-5	2002	This lithium-induced up-regulation of NF-kappa B and MAP kinase activation was associated with an enhancement of interleukin-8 mRNA accumulation as well as an increase in interleukin-8 protein release.	Lithium	5-12	C-X-C motif chemokine ligand 8	Homo sapiens	171-184
11906276-0	2002	Effects of coligand variation on the in vivo characteristics of Tc-99m-labeled interleukin-8 in detection of infection.	Technetium	64-70	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
11906276-1	2002	In our previous studies, interleukin-8 (IL-8) was labeled with (99m)Tc using hydrazinonicotinamide (HYNIC) as bifunctional coupling agent and tricine as coligand.	Technetium	63-70	C-X-C motif chemokine ligand 8	Homo sapiens	25-38
11906276-1	2002	In our previous studies, interleukin-8 (IL-8) was labeled with (99m)Tc using hydrazinonicotinamide (HYNIC) as bifunctional coupling agent and tricine as coligand.	Technetium	63-70	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
11906276-1	2002	In our previous studies, interleukin-8 (IL-8) was labeled with (99m)Tc using hydrazinonicotinamide (HYNIC) as bifunctional coupling agent and tricine as coligand.	hydrazino nicotinamide	77-98	C-X-C motif chemokine ligand 8	Homo sapiens	25-38
11906276-1	2002	In our previous studies, interleukin-8 (IL-8) was labeled with (99m)Tc using hydrazinonicotinamide (HYNIC) as bifunctional coupling agent and tricine as coligand.	hydrazino nicotinamide	77-98	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
11906276-1	2002	In our previous studies, interleukin-8 (IL-8) was labeled with (99m)Tc using hydrazinonicotinamide (HYNIC) as bifunctional coupling agent and tricine as coligand.	tricine	142-149	C-X-C motif chemokine ligand 8	Homo sapiens	25-38
11906276-1	2002	In our previous studies, interleukin-8 (IL-8) was labeled with (99m)Tc using hydrazinonicotinamide (HYNIC) as bifunctional coupling agent and tricine as coligand.	tricine	142-149	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
11906276-3	2002	In the present study, the propylaldehyde hydrazone formulation of HYNIC was introduced to stabilize HYNIC-IL-8.	propylaldehyde hydrazone	26-50	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
11906276-6	2002	HYNIC-conjugated IL-8 was labeled with (99m)Tc in the presence of either (A) tricine, (B) ethylenediaminediacetic acid (EDDA), (C) tricine and trisodium triphenylphosphinetrisulfonate (TPPTS), (D) tricine and nicotinic acid (NIC), or (E) tricine and isonicotinic acid (ISONIC).	Technetium	44-46	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
11906276-6	2002	HYNIC-conjugated IL-8 was labeled with (99m)Tc in the presence of either (A) tricine, (B) ethylenediaminediacetic acid (EDDA), (C) tricine and trisodium triphenylphosphinetrisulfonate (TPPTS), (D) tricine and nicotinic acid (NIC), or (E) tricine and isonicotinic acid (ISONIC).	tricine	77-84	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
11906276-6	2002	HYNIC-conjugated IL-8 was labeled with (99m)Tc in the presence of either (A) tricine, (B) ethylenediaminediacetic acid (EDDA), (C) tricine and trisodium triphenylphosphinetrisulfonate (TPPTS), (D) tricine and nicotinic acid (NIC), or (E) tricine and isonicotinic acid (ISONIC).	EDDA	90-118	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
11906276-6	2002	HYNIC-conjugated IL-8 was labeled with (99m)Tc in the presence of either (A) tricine, (B) ethylenediaminediacetic acid (EDDA), (C) tricine and trisodium triphenylphosphinetrisulfonate (TPPTS), (D) tricine and nicotinic acid (NIC), or (E) tricine and isonicotinic acid (ISONIC).	EDDA	120-124	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
11906276-6	2002	HYNIC-conjugated IL-8 was labeled with (99m)Tc in the presence of either (A) tricine, (B) ethylenediaminediacetic acid (EDDA), (C) tricine and trisodium triphenylphosphinetrisulfonate (TPPTS), (D) tricine and nicotinic acid (NIC), or (E) tricine and isonicotinic acid (ISONIC).	tricine	131-138	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
11906276-6	2002	HYNIC-conjugated IL-8 was labeled with (99m)Tc in the presence of either (A) tricine, (B) ethylenediaminediacetic acid (EDDA), (C) tricine and trisodium triphenylphosphinetrisulfonate (TPPTS), (D) tricine and nicotinic acid (NIC), or (E) tricine and isonicotinic acid (ISONIC).	trisodium triphenylphosphinetrisulfonate	143-183	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
11906276-6	2002	HYNIC-conjugated IL-8 was labeled with (99m)Tc in the presence of either (A) tricine, (B) ethylenediaminediacetic acid (EDDA), (C) tricine and trisodium triphenylphosphinetrisulfonate (TPPTS), (D) tricine and nicotinic acid (NIC), or (E) tricine and isonicotinic acid (ISONIC).	Sodium 3,3',3''-phosphinetriyltribenzenesulfonate	185-190	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
11906276-6	2002	HYNIC-conjugated IL-8 was labeled with (99m)Tc in the presence of either (A) tricine, (B) ethylenediaminediacetic acid (EDDA), (C) tricine and trisodium triphenylphosphinetrisulfonate (TPPTS), (D) tricine and nicotinic acid (NIC), or (E) tricine and isonicotinic acid (ISONIC).	tricine	131-138	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
11906276-6	2002	HYNIC-conjugated IL-8 was labeled with (99m)Tc in the presence of either (A) tricine, (B) ethylenediaminediacetic acid (EDDA), (C) tricine and trisodium triphenylphosphinetrisulfonate (TPPTS), (D) tricine and nicotinic acid (NIC), or (E) tricine and isonicotinic acid (ISONIC).	Niacin	209-223	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
11906276-6	2002	HYNIC-conjugated IL-8 was labeled with (99m)Tc in the presence of either (A) tricine, (B) ethylenediaminediacetic acid (EDDA), (C) tricine and trisodium triphenylphosphinetrisulfonate (TPPTS), (D) tricine and nicotinic acid (NIC), or (E) tricine and isonicotinic acid (ISONIC).	Niacin	2-5	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
11906276-6	2002	HYNIC-conjugated IL-8 was labeled with (99m)Tc in the presence of either (A) tricine, (B) ethylenediaminediacetic acid (EDDA), (C) tricine and trisodium triphenylphosphinetrisulfonate (TPPTS), (D) tricine and nicotinic acid (NIC), or (E) tricine and isonicotinic acid (ISONIC).	tricine	131-138	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
11877327-4	2002	Pre-stimulation of cells with adenosine 5"-triphosphate (ATP) revealed a substantial Ca(2+) signalling component mediated by IL-8 (E(max)=83 +/- 8% of maximal ATP response, pEC(50) of IL-8 response=9.7 +/- 0.1).	Adenosine Triphosphate	159-162	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
11906276-6	2002	HYNIC-conjugated IL-8 was labeled with (99m)Tc in the presence of either (A) tricine, (B) ethylenediaminediacetic acid (EDDA), (C) tricine and trisodium triphenylphosphinetrisulfonate (TPPTS), (D) tricine and nicotinic acid (NIC), or (E) tricine and isonicotinic acid (ISONIC).	Isonicotinic Acids	250-267	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
11877327-9	2002	Both UTP and 2MeSADP increased the potency and magnitude of IL-8-mediated [Ca(2+)](i) elevation but the effects of UTP (E(max) of IL-8 response increased to 50 +/- 1% of the maximal response to ATP, pEC(50) increased to 9.8 +/- 0.1) were greater than those of 2MeSADP (E(max) increased to 36 +/- 2%, pEC(50) increased to 8.7 +/- 0.2).	Uridine Triphosphate	5-8	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
11906276-16	2002	IL-8 can be rapidly and easily labeled with (99m)Tc using HYNIC as a chelator in combination with various coligands.	Technetium	44-51	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
11877327-9	2002	Both UTP and 2MeSADP increased the potency and magnitude of IL-8-mediated [Ca(2+)](i) elevation but the effects of UTP (E(max) of IL-8 response increased to 50 +/- 1% of the maximal response to ATP, pEC(50) increased to 9.8 +/- 0.1) were greater than those of 2MeSADP (E(max) increased to 36 +/- 2%, pEC(50) increased to 8.7 +/- 0.2).	methylthio-ADP	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
11877327-9	2002	Both UTP and 2MeSADP increased the potency and magnitude of IL-8-mediated [Ca(2+)](i) elevation but the effects of UTP (E(max) of IL-8 response increased to 50 +/- 1% of the maximal response to ATP, pEC(50) increased to 9.8 +/- 0.1) were greater than those of 2MeSADP (E(max) increased to 36 +/- 2%, pEC(50) increased to 8.7 +/- 0.2).	Uridine Triphosphate	115-118	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
11877327-9	2002	Both UTP and 2MeSADP increased the potency and magnitude of IL-8-mediated [Ca(2+)](i) elevation but the effects of UTP (E(max) of IL-8 response increased to 50 +/- 1% of the maximal response to ATP, pEC(50) increased to 9.8 +/- 0.1) were greater than those of 2MeSADP (E(max) increased to 36 +/- 2%, pEC(50) increased to 8.7 +/- 0.2).	Adenosine Triphosphate	194-197	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
11877327-12	2002	The potentiation of IL-8-mediated Ca(2+) signalling by UTP was not dependent upon the time of IL-8 addition following UTP but was dependent on the continued presence of UTP.	Uridine Triphosphate	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
11877327-12	2002	The potentiation of IL-8-mediated Ca(2+) signalling by UTP was not dependent upon the time of IL-8 addition following UTP but was dependent on the continued presence of UTP.	Uridine Triphosphate	118-121	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
11877327-12	2002	The potentiation of IL-8-mediated Ca(2+) signalling by UTP was not dependent upon the time of IL-8 addition following UTP but was dependent on the continued presence of UTP.	Uridine Triphosphate	118-121	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
11882700-3	2002	This study shows that treatment of human intestinal epithelial T84 cells with Etx induces expression of IL-6, IL-10, IL-1R antagonist, as well as IL-1alpha and IL-1beta and low levels of IL-8.	2-ethoxyethanol	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
11966773-8	2002	The MAPK p38 appears necessary for the regulation of IL-8, GRO-alpha and GRO-beta expression as shown by inhibition with SB203580.	SB 203580	121-129	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
11966773-9	2002	The inhibitors genistein (tyrosine kinase inhibitor) and calphostin C (inhibitor of protein kinase C) reduced significantly the IL-17-stimulated mRNA expression of IL-8, GRO-alpha and GRO-beta in SFC, whereas PD98059 (inhibitor of MEK-1/2) was without effect.	Genistein	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
11966773-9	2002	The inhibitors genistein (tyrosine kinase inhibitor) and calphostin C (inhibitor of protein kinase C) reduced significantly the IL-17-stimulated mRNA expression of IL-8, GRO-alpha and GRO-beta in SFC, whereas PD98059 (inhibitor of MEK-1/2) was without effect.	calphostin C	57-69	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
11966773-9	2002	The inhibitors genistein (tyrosine kinase inhibitor) and calphostin C (inhibitor of protein kinase C) reduced significantly the IL-17-stimulated mRNA expression of IL-8, GRO-alpha and GRO-beta in SFC, whereas PD98059 (inhibitor of MEK-1/2) was without effect.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	209-216	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
11966773-10	2002	Pharmacological drugs used in therapy of RA, such as cyclosporin and methotrexate, induced a fourfold increase of IL-17R mRNA expression and augmented the IL-17-stimulated IL-8 expression.	Cyclosporine	53-64	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
11966773-10	2002	Pharmacological drugs used in therapy of RA, such as cyclosporin and methotrexate, induced a fourfold increase of IL-17R mRNA expression and augmented the IL-17-stimulated IL-8 expression.	Methotrexate	69-81	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
11954986-5	2002	RESULTS: Levels of IL-6 and IL-8 significantly increased in subjects with high urine Cr concentration, but TNF-alpha levels decreased.	Chromium	85-87	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
11876744-0	2002	Lidocaine inhibits secretion of IL-8 and IL-1beta and stimulates secretion of IL-1 receptor antagonist by epithelial cells.	Lidocaine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
11914967-3	2002	LPS-stimulated cells treated with 0.1 microg/ml bisbenzylisoquinoline alkaloid fraction exhibited a 40% inhibition of IL-8 production in comparison with control cells.	bisbenzylisoquinoline alkaloid	48-78	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
11814358-3	2002	The binding affinities, obtained by isothermal fluorescence titration, of size-defined heparin and HS oligosaccharides to the chemokine were found to depend on the oligomerization state of IL-8: high affinity was detected for monomeric and low affinity was detected for dimeric IL-8, referring to a self-regulatory mechanism for its chemoattractant effect.	hs oligosaccharides	99-118	C-X-C motif chemokine ligand 8	Homo sapiens	278-282
11814358-6	2002	Instead, a periodic pattern was obtained for the dissociation constants of the GAG oligosaccharides with respect to chain length, referring to optimum and least optimum chain lengths for IL-8 binding.	gag oligosaccharides	79-99	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
11814358-9	2002	Thermal unfolding of IL-8 yielded a single transition at 56 degrees C which was completely prevented by the presence of undigested HS or heparin, indicating structural stabilization, thereby prolonging the biological effect of the chemokine.	Heparitin Sulfate	131-133	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
11814358-9	2002	Thermal unfolding of IL-8 yielded a single transition at 56 degrees C which was completely prevented by the presence of undigested HS or heparin, indicating structural stabilization, thereby prolonging the biological effect of the chemokine.	Heparin	137-144	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
11806993-8	2002	Calcium mobilization was studied in neutrophils upon activation with formyl-Met-Leu-Phe (fMLP), adenosine diphosphate (ADP), platelet-activating factor (PAF), interleukin-8 (IL-8), C5a, and leukotriene B(4) (LTB(4)), and it was normal.	Calcium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	159-172
11806993-8	2002	Calcium mobilization was studied in neutrophils upon activation with formyl-Met-Leu-Phe (fMLP), adenosine diphosphate (ADP), platelet-activating factor (PAF), interleukin-8 (IL-8), C5a, and leukotriene B(4) (LTB(4)), and it was normal.	Calcium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
11846460-2	2002	We also demonstrated that Tau-Cl suppressed superoxide anion, IL-6, and IL-8 production in activated human polymorphonuclear leukocytes separated from peripheral blood.	N-chlorotaurine	26-32	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
11814358-0	2002	Different affinities of glycosaminoglycan oligosaccharides for monomeric and dimeric interleukin-8: a model for chemokine regulation at inflammatory sites.	glycosaminoglycan oligosaccharides	24-58	C-X-C motif chemokine ligand 8	Homo sapiens	85-98
11814358-1	2002	The binding of interleukin-8 (IL-8) to heparan sulfate (HS) proteoglycans on the surface of endothelial cells is crucial for the recruitment of neutrophils to an inflammatory site.	Heparitin Sulfate	39-54	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
11814358-1	2002	The binding of interleukin-8 (IL-8) to heparan sulfate (HS) proteoglycans on the surface of endothelial cells is crucial for the recruitment of neutrophils to an inflammatory site.	Heparitin Sulfate	39-54	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
11814358-1	2002	The binding of interleukin-8 (IL-8) to heparan sulfate (HS) proteoglycans on the surface of endothelial cells is crucial for the recruitment of neutrophils to an inflammatory site.	Heparitin Sulfate	56-58	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
11814358-1	2002	The binding of interleukin-8 (IL-8) to heparan sulfate (HS) proteoglycans on the surface of endothelial cells is crucial for the recruitment of neutrophils to an inflammatory site.	Heparitin Sulfate	56-58	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
11814358-3	2002	The binding affinities, obtained by isothermal fluorescence titration, of size-defined heparin and HS oligosaccharides to the chemokine were found to depend on the oligomerization state of IL-8: high affinity was detected for monomeric and low affinity was detected for dimeric IL-8, referring to a self-regulatory mechanism for its chemoattractant effect.	Heparin	87-94	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
11814358-3	2002	The binding affinities, obtained by isothermal fluorescence titration, of size-defined heparin and HS oligosaccharides to the chemokine were found to depend on the oligomerization state of IL-8: high affinity was detected for monomeric and low affinity was detected for dimeric IL-8, referring to a self-regulatory mechanism for its chemoattractant effect.	Heparin	87-94	C-X-C motif chemokine ligand 8	Homo sapiens	278-282
11814358-3	2002	The binding affinities, obtained by isothermal fluorescence titration, of size-defined heparin and HS oligosaccharides to the chemokine were found to depend on the oligomerization state of IL-8: high affinity was detected for monomeric and low affinity was detected for dimeric IL-8, referring to a self-regulatory mechanism for its chemoattractant effect.	hs oligosaccharides	99-118	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
11846460-6	2002	Production of IL-6, IL-8, and IL-2 in PHA-activated nonadherent leukocytes was inhibited by Tau-Cl.	N-chlorotaurine	92-98	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
11846460-7	2002	The production of IL-1beta, IL-6, and IL-8 was also decreased in LPS-activated adherent monocytes by Tau-Cl.	N-chlorotaurine	101-107	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
11876744-7	2002	In further experiments, the effect of lidocaine on the secretion of IL-8 from freshly isolated epithelial cells stimulated with TNFalpha was tested.	Lidocaine	38-47	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
11876744-8	2002	Lidocaine, in therapeutic concentrations, inhibited the spontaneous and TNFalpha-stimulated secretion of IL-8 and IL-1beta from HT-29 and Caco-2 cell lines in a dose-dependent manner.	Lidocaine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
11972286-0	2002	alpha-Tocopherol Inhibits IL-8 synthesis induced by thrombin and high glucose in endothelial cells.	alpha-Tocopherol	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
11855542-6	2002	The mucosal production of RANTES, interleukin-8, and TNF-alpha showed a significant decrease after eradication in patients with rebamipide after-treatment.	rebamipide	128-138	C-X-C motif chemokine ligand 8	Homo sapiens	34-47
11972286-0	2002	alpha-Tocopherol Inhibits IL-8 synthesis induced by thrombin and high glucose in endothelial cells.	Glucose	70-77	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
12022438-2	2002	Here we report the inhibitory effects of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) on IL-8 production in human whole blood culture.	1alpha,25-dihydroxyvitamin d3 (1,25(oh)2d3	41-83	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
12022438-3	2002	1,25(OH)2D3 inhibited only the late phase of the biphasic IL-8 production in lipopolysaccharide-stimulated human whole blood.	Calcitriol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
11972286-3	2002	Therefore, we examined the effect of alpha-tocopherol on the regulation of IL-8 synthesis induced by high glucose and/or thrombin in endothelial cells.	alpha-Tocopherol	37-53	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
12022438-6	2002	Although monocytes were found to be mainly responsible for IL-1beta-induced IL-8 production in whole blood, 1,25(OH)2D3 inhibited IL-8 production by isolated mononuclear cells only marginally.	Calcitriol	108-119	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
11972286-3	2002	Therefore, we examined the effect of alpha-tocopherol on the regulation of IL-8 synthesis induced by high glucose and/or thrombin in endothelial cells.	Glucose	106-113	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
12022438-8	2002	These results suggest that erythrocytes play a role in mediating the inhibitory effects of 1,25(OH)2D3 on IL-8 production in IL-1beta-stimulated whole blood.	Calcitriol	91-102	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
11972286-5	2002	Furthermore, high glucose levels and thrombin combined had additive effects on IL-8 synthesis, and alpha-tocopherol diminished their effect; alpha-tocopherol also inhibited the phosphorylation of IkappaB-alpha induced by high glucose levels and/or thrombin.	Glucose	18-25	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
11972286-5	2002	Furthermore, high glucose levels and thrombin combined had additive effects on IL-8 synthesis, and alpha-tocopherol diminished their effect; alpha-tocopherol also inhibited the phosphorylation of IkappaB-alpha induced by high glucose levels and/or thrombin.	alpha-Tocopherol	141-157	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
11972286-6	2002	Our results suggest that the administration of alpha-tocopherol to diabetic patients may have a beneficial effect for the prevention of diabetic vascular complications by the inhibition of IL-8 synthesis from endothelial cells.	alpha-Tocopherol	47-63	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
12022438-0	2002	1 alpha,25-dihydroxyvitamin D3 suppresses interleukin-1beta-induced interleukin-8 production in human whole blood: an involvement of erythrocytes in the inhibition.	Calcitriol	0-30	C-X-C motif chemokine ligand 8	Homo sapiens	68-81
11880144-1	2002	We show that treatment of cerebellar granules with interleukin-8 (IL-8), growth-related gene product beta (GRObeta) or AMPA induced activation of PI3-K/Akt and of ERK pathways, the latter being independent of PI3-K and dependent on PTX-sensitive G proteins.	ptx	232-235	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
11801678-0	2002	15-deoxy-Delta 12,14-PGJ2 induces IL-8 production in human T cells by a mitogen-activated protein kinase pathway.	15-deoxy-delta(12,14)-prostaglandin J2	0-25	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
11801678-9	2002	In this study, we report that 15-d-PGJ(2) induced a significant increase in both IL-8 mRNA and protein from activated human T lymphocytes.	15-d-pgj	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
11801678-10	2002	The induction of IL-8 by 15-d-PGJ(2) did not occur through the nuclear receptor PPAR-gamma, as synthetic PPAR-gamma agonists did not mimic the IL-8-inducing effects of 15-d-PGJ(2).	15-d-pgj	25-33	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
11911801-6	2002	In contrast, preincubation of the monocytes with the protein tyrosine kinase (PTK) inhibitor genistein resulted in dose-dependent suppression of mycobacteria-induced CXCL-8 secretion.	Genistein	93-102	C-X-C motif chemokine ligand 8	Homo sapiens	166-172
11911801-7	2002	These results were further supported by the fact that treatment of monocytes with herbimycin-A, another well-described inhibitor of PTK activity with a different mechanism of action, significantly diminished the effect of M. bovis on CXCL-8 secretion.	herbimycin	82-94	C-X-C motif chemokine ligand 8	Homo sapiens	234-240
11911801-10	2002	Finally, two specific NF-kappa B inhibitors, sulfasalazine and caffeic acid phenetyl ester (CAPE), strongly inhibited the production of CXCL-8 by human monocytes infected with M. bovis.	Sulfasalazine	45-58	C-X-C motif chemokine ligand 8	Homo sapiens	136-142
11911801-10	2002	Finally, two specific NF-kappa B inhibitors, sulfasalazine and caffeic acid phenetyl ester (CAPE), strongly inhibited the production of CXCL-8 by human monocytes infected with M. bovis.	caffeic acid phenetyl ester	63-90	C-X-C motif chemokine ligand 8	Homo sapiens	136-142
11911801-10	2002	Finally, two specific NF-kappa B inhibitors, sulfasalazine and caffeic acid phenetyl ester (CAPE), strongly inhibited the production of CXCL-8 by human monocytes infected with M. bovis.	caffeic acid phenethyl ester	92-96	C-X-C motif chemokine ligand 8	Homo sapiens	136-142
11880144-1	2002	We show that treatment of cerebellar granules with interleukin-8 (IL-8), growth-related gene product beta (GRObeta) or AMPA induced activation of PI3-K/Akt and of ERK pathways, the latter being independent of PI3-K and dependent on PTX-sensitive G proteins.	ptx	232-235	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
12774392-2	2002	METHOD: The amounts of IFN-alpha, IFN-gamma, TNF-alpha, IL-8 in the peripheral blood mononuclear cells(PBMCs) culture supernatants deal with by different concentrations of LianBiZhi (LBZ) injection made of andrographolide were detected by biological activity test or ELISA in vitro.	lianbizhi	172-181	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
12774392-2	2002	METHOD: The amounts of IFN-alpha, IFN-gamma, TNF-alpha, IL-8 in the peripheral blood mononuclear cells(PBMCs) culture supernatants deal with by different concentrations of LianBiZhi (LBZ) injection made of andrographolide were detected by biological activity test or ELISA in vitro.	lbz	183-186	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
11782202-5	2002	The FB1-cholesterol complex was reinforced by NaCl but was destabilized by NaF, a salt known to break hydrogen bonds.	Cholesterol	8-19	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
11782202-5	2002	The FB1-cholesterol complex was reinforced by NaCl but was destabilized by NaF, a salt known to break hydrogen bonds.	Hydrogen	102-110	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
11807693-6	2002	GBS invasion and IL-8 induction were significantly reduced in the presence of dipalmotyl phosphatidylcholine, a major constituent of lung surfactant and a known inhibitor of beta-h/c activity.	dipalmotyl phosphatidylcholine	78-108	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
11790657-5	2002	IL-8 levels after 2 h of reperfusion correlated with lung function assessed by the Pa(O2 )/FI(O(2)) ratio, the mean airway pressure, and the APACHE score during the first 24 postoperative hours.	o2 )	86-90	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
11777986-10	2002	Furthermore, intracellularly delivered dexamethasone was able to down-regulate the proinflammatory gene IL-8.	Dexamethasone	39-52	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
11755918-0	2002	Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages.	Prostaglandin D2	44-60	C-X-C motif chemokine ligand 8	Homo sapiens	16-29
12136943-7	2002	They appeared to undergo a change in the phenotype induced by NaB, as indicated by reduced proliferation, enhanced differentiation, stimulation of apoptosis leading to decreased viability of cells, and stimulation of interleukin-8 secretion.	nab	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	217-230
11755918-0	2002	Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages.	15-deoxy-delta12	72-88	C-X-C motif chemokine ligand 8	Homo sapiens	16-29
11755918-0	2002	Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages.	9-deoxy-delta-9-prostaglandin D2	93-109	C-X-C motif chemokine ligand 8	Homo sapiens	16-29
11755918-2	2002	The expression of IL-8 gene can be induced in cholesterol loaded THP-1 macrophages by oxidized low density lipoprotein.	Cholesterol	46-57	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
11755918-3	2002	We report for the first time that the expression of human IL-8 gene in THP-1 macrophages is upregulated in a time- and concentration-dependent manner by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2), which is a natural ligand for activation of peroxisome proliferator-activated receptor-gamma transcription factor.	Prostaglandin D2	153-169	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
11755918-3	2002	We report for the first time that the expression of human IL-8 gene in THP-1 macrophages is upregulated in a time- and concentration-dependent manner by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2), which is a natural ligand for activation of peroxisome proliferator-activated receptor-gamma transcription factor.	15-deoxy-delta12	181-197	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
11755918-3	2002	We report for the first time that the expression of human IL-8 gene in THP-1 macrophages is upregulated in a time- and concentration-dependent manner by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2), which is a natural ligand for activation of peroxisome proliferator-activated receptor-gamma transcription factor.	9-deoxy-delta-9-prostaglandin D2	202-218	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
11762855-8	2002	When the NaF concentration was lower than 0.10%, the Rp value (&gt; 3.4 x 10(5) omega cm2) was mainly ascribed to the formation of a protective titanium dioxide (TiO2) on the metal surface, regardless of the elastic tensile strain applied.	titanium dioxide	144-160	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
11824547-0	2002	Synergistic action of beta-glucan and platelets on interleukin-8 production by human peripheral blood leukocytes.	beta-Glucans	22-33	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
11762855-8	2002	When the NaF concentration was lower than 0.10%, the Rp value (&gt; 3.4 x 10(5) omega cm2) was mainly ascribed to the formation of a protective titanium dioxide (TiO2) on the metal surface, regardless of the elastic tensile strain applied.	titanium dioxide	162-166	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
11755918-3	2002	We report for the first time that the expression of human IL-8 gene in THP-1 macrophages is upregulated in a time- and concentration-dependent manner by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2), which is a natural ligand for activation of peroxisome proliferator-activated receptor-gamma transcription factor.	15-deoxy-delta(12,14)-prostaglandin J2	220-228	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
11762855-8	2002	When the NaF concentration was lower than 0.10%, the Rp value (&gt; 3.4 x 10(5) omega cm2) was mainly ascribed to the formation of a protective titanium dioxide (TiO2) on the metal surface, regardless of the elastic tensile strain applied.	Metals	175-180	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
11755918-4	2002	Studies to identify the signal transduction pathways involved showed that IL-8 upregulation-mediated by 15d-PGJ2 was markedly inhibited when the THP-1 macrophages were incubated with a highly selective and cell-permeable inhibitor of the mitogen-activated protein kinase (MAPK) signaling pathway, 2"-amino-3"-methoxyflavone (PD98059).	15-deoxy-delta(12,14)-prostaglandin J2	104-112	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
11762855-9	2002	However, when the NaF concentration was higher than 0.1%, the protectiveness of TiO2 was destroyed by fluoride ions, leading to severe corrosion of CP titanium.	titanium dioxide	80-84	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
11762855-9	2002	However, when the NaF concentration was higher than 0.1%, the protectiveness of TiO2 was destroyed by fluoride ions, leading to severe corrosion of CP titanium.	Fluorides	102-110	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
11755918-4	2002	Studies to identify the signal transduction pathways involved showed that IL-8 upregulation-mediated by 15d-PGJ2 was markedly inhibited when the THP-1 macrophages were incubated with a highly selective and cell-permeable inhibitor of the mitogen-activated protein kinase (MAPK) signaling pathway, 2"-amino-3"-methoxyflavone (PD98059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	297-323	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
11755918-4	2002	Studies to identify the signal transduction pathways involved showed that IL-8 upregulation-mediated by 15d-PGJ2 was markedly inhibited when the THP-1 macrophages were incubated with a highly selective and cell-permeable inhibitor of the mitogen-activated protein kinase (MAPK) signaling pathway, 2"-amino-3"-methoxyflavone (PD98059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	325-332	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
11755918-5	2002	This inhibition was concentration-dependent, suggesting that 15d-PGJ2 regulates the expression of IL-8 gene in THP-1 macrophages through a MAPK signaling pathway.	15-deoxy-delta(12,14)-prostaglandin J2	61-69	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
11755918-6	2002	In contrast, THP-1 macrophages when treated with pyrrolidine dithiocarbamate, an anti-oxidant and the selective inhibitor for nuclear factor kappaB, showed an enhanced 15d-PGJ2-mediated upregulation of IL-8 gene expression.	pyrrolidine dithiocarbamic acid	49-76	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
11755918-6	2002	In contrast, THP-1 macrophages when treated with pyrrolidine dithiocarbamate, an anti-oxidant and the selective inhibitor for nuclear factor kappaB, showed an enhanced 15d-PGJ2-mediated upregulation of IL-8 gene expression.	9-deoxy-delta-9-prostaglandin D2	171-176	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
12090473-6	2002	Both cytokines enhanced the ability of the cells to adhere to the CD44-specific ligand hyaluronic acid, an effect that was specifically blocked by an anti-IL-8 antibody.	Hyaluronic Acid	87-102	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
12666825-5	2002	There were positive important correlations between plasma selenium and IL-2r, copper and IL-6, and copper and IL-1beta, and negative correlations between selenium and IL-8, iron and TNF-alpha, and zinc and IL-1beta contents in patients with CL.	Selenium	154-162	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
11841414-6	2002	IL-8 concentrations were weakly correlated with age, male sex, and concentrations of C-reactive protein, factor VIII coagulation activity and homocysteine, but adjustment for these factors did not substantially affect the association between IL-8 and venous thrombosis.	Homocysteine	142-154	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12083423-0	2002	Suppression of sulfur mustard-increased IL-8 in human keratinocyte cell cultures by serine protease inhibitors: implications for toxicity and medical countermeasures.	Mustard Gas	15-29	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
12083423-9	2002	The suppression of SM-increased IL-8 by a class of drug candidate compounds such as protease inhibitors may provide a mechanistic marker that helps predict future medical countermeasures for SM toxicity and reduces the need for testing in animal models.	Samarium	19-21	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
11789672-8	2002	When M-CSF was added to cultured PBM, the level of IL-8 in the supernatant increased with the concentration of M-CSF.	pbm	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
11740968-0	2002	Regulation of NaF release from bis-GMA/TEGDMA resin using gamma-methacryloxypropyltrimethoxysilane.	Bisphenol A-Glycidyl Methacrylate	31-38	C-X-C motif chemokine ligand 8	Homo sapiens	14-17
11740968-0	2002	Regulation of NaF release from bis-GMA/TEGDMA resin using gamma-methacryloxypropyltrimethoxysilane.	triethylene glycol dimethacrylate	39-45	C-X-C motif chemokine ligand 8	Homo sapiens	14-17
11740968-0	2002	Regulation of NaF release from bis-GMA/TEGDMA resin using gamma-methacryloxypropyltrimethoxysilane.	methacryloxypropyltrimethoxysilane	58-98	C-X-C motif chemokine ligand 8	Homo sapiens	14-17
11740968-1	2002	OBJECTIVES: The aim of this study was to evaluate the feasibility of regulation of NaF release from bis-GMA/TEGDMA resin using gamma-methacryloxypropyltrimethoxysilane (gamma-MPTS).	Bisphenol A-Glycidyl Methacrylate	100-107	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
11740968-1	2002	OBJECTIVES: The aim of this study was to evaluate the feasibility of regulation of NaF release from bis-GMA/TEGDMA resin using gamma-methacryloxypropyltrimethoxysilane (gamma-MPTS).	triethylene glycol dimethacrylate	108-114	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
11740968-1	2002	OBJECTIVES: The aim of this study was to evaluate the feasibility of regulation of NaF release from bis-GMA/TEGDMA resin using gamma-methacryloxypropyltrimethoxysilane (gamma-MPTS).	methacryloxypropyltrimethoxysilane	127-167	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
11740968-1	2002	OBJECTIVES: The aim of this study was to evaluate the feasibility of regulation of NaF release from bis-GMA/TEGDMA resin using gamma-methacryloxypropyltrimethoxysilane (gamma-MPTS).	methacryloxypropyltrimethoxysilane	169-179	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
11740968-2	2002	METHODS: NaF powder was treated with gamma-MPTS to form a polysiloxane layer on its surface.	methacryloxypropyltrimethoxysilane	37-47	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
11740968-2	2002	METHODS: NaF powder was treated with gamma-MPTS to form a polysiloxane layer on its surface.	Siloxanes	58-70	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
11740968-4	2002	Bis-GMA/TEGDMA resin containing 50 wt% NaF powder was prepared as a model resin and immersed in distilled water at 37 degrees C, and the amount of fluoride released from the resin was measured using a fluoride electrode.	Bisphenol A-Glycidyl Methacrylate	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
11740968-6	2002	RESULTS: NaF powder was covered with hydrophobic gamma-MPTS delivered polysiloxane.	methacryloxypropyltrimethoxysilane	49-59	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
11740968-6	2002	RESULTS: NaF powder was covered with hydrophobic gamma-MPTS delivered polysiloxane.	Siloxanes	70-82	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
11740968-7	2002	A larger amount of fluoride was released at the initial stage from the resin containing NaF treated with no gamma-MPTS.	Fluorides	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	88-91
11740968-9	2002	In contrast, we observed a smaller amount of fluoride released for a longer period from the resin containing NaF treated with gamma-MPTS.	Fluorides	45-53	C-X-C motif chemokine ligand 8	Homo sapiens	109-112
11740968-9	2002	In contrast, we observed a smaller amount of fluoride released for a longer period from the resin containing NaF treated with gamma-MPTS.	methacryloxypropyltrimethoxysilane	126-136	C-X-C motif chemokine ligand 8	Homo sapiens	109-112
11740968-10	2002	SIGNIFICANCE: We found that gamma-MPTS treatment is useful for the regulation of NaF release from bis-GMA/TEGDMA resin.	methacryloxypropyltrimethoxysilane	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
11740968-10	2002	SIGNIFICANCE: We found that gamma-MPTS treatment is useful for the regulation of NaF release from bis-GMA/TEGDMA resin.	Bisphenol A-Glycidyl Methacrylate	98-105	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
11740968-10	2002	SIGNIFICANCE: We found that gamma-MPTS treatment is useful for the regulation of NaF release from bis-GMA/TEGDMA resin.	triethylene glycol dimethacrylate	106-112	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
11740968-11	2002	The mechanism of slow NaF release may be the formation of a hydrophobic polysiloxane layer on the surface of NaF powder and resulting slow water diffusion to NaF powder.	Siloxanes	72-84	C-X-C motif chemokine ligand 8	Homo sapiens	22-25
11740968-11	2002	The mechanism of slow NaF release may be the formation of a hydrophobic polysiloxane layer on the surface of NaF powder and resulting slow water diffusion to NaF powder.	Siloxanes	72-84	C-X-C motif chemokine ligand 8	Homo sapiens	109-112
11740968-11	2002	The mechanism of slow NaF release may be the formation of a hydrophobic polysiloxane layer on the surface of NaF powder and resulting slow water diffusion to NaF powder.	Siloxanes	72-84	C-X-C motif chemokine ligand 8	Homo sapiens	109-112
11740968-11	2002	The mechanism of slow NaF release may be the formation of a hydrophobic polysiloxane layer on the surface of NaF powder and resulting slow water diffusion to NaF powder.	Water	139-144	C-X-C motif chemokine ligand 8	Homo sapiens	22-25
11789672-9	2002	When IL-8 was added to cultured granulocytes, the levels of CD18 expression on granulocytes and superoxide anion production by granulocytes were significantly increased.	Superoxides	96-112	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
11916128-4	2002	We found that histamine significantly augmented the production of IL-6 and IL-8 in a dose- and time-dependent manner.	Histamine	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
11916128-0	2002	Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-gamma and IL-4 in human keratinocytes.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
12182553-6	2002	Induction of interleukin-8 (IL-8) secretion was detected on PAH and PLL ending polyelectrolyte films.	polyallylamine	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	13-26
12182553-6	2002	Induction of interleukin-8 (IL-8) secretion was detected on PAH and PLL ending polyelectrolyte films.	polyallylamine	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
11835523-9	2002	High glucose may stimulate MCP-1 and/or IL-8 production and their excretion into the urine independently of the phases or pathological lesions of this disease.	Glucose	5-12	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
11916128-7	2002	The histamine-induced up-regulation of IL-6 and IL-8 production, however, was completely abrogated by a combination of pyrilamine and cimetidine.	Histamine	4-13	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
11916128-3	2002	We therefore examined the capacity of histamine to modulate the production of interleukin (IL)-6 and IL-8 by keratinocytes.	Histamine	38-47	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
11916128-7	2002	The histamine-induced up-regulation of IL-6 and IL-8 production, however, was completely abrogated by a combination of pyrilamine and cimetidine.	Pyrilamine	119-129	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
11916128-7	2002	The histamine-induced up-regulation of IL-6 and IL-8 production, however, was completely abrogated by a combination of pyrilamine and cimetidine.	Cimetidine	134-144	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
11916128-10	2002	On the other hand, the production of IL-8 was inhibited by IFN-gamma, and IFN-gamma and IL-4 both completely abrogated the histamine-induced IL-8 production.	Histamine	123-132	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
11916128-10	2002	On the other hand, the production of IL-8 was inhibited by IFN-gamma, and IFN-gamma and IL-4 both completely abrogated the histamine-induced IL-8 production.	Histamine	123-132	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
11916128-11	2002	These results suggest that the histamine-induced IL-6 production and IL-8 production are differentially regulated by IFN-gamma and IL-4.	Histamine	31-40	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
11813828-6	2002	Preincubation with the PKC inhibitor calphostin C (1 microM) significantly suppressed IL-8 release in HBEC treated with CSE and C5a.	calphostin C	37-49	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
11813828-7	2002	Preincubation with 10 microM TMB-8 (an intracellular calcium sequester) also significantly suppressed IL-8 release in CSE- and C5a-treated HBEC, suggesting that intracellular calcium is required for CSE- and C5a-mediated IL-8 release.	Calcium	175-182	C-X-C motif chemokine ligand 8	Homo sapiens	221-225
11813828-8	2002	When HBEC were preincubated with 30 nM of the PKCbeta-specific inhibitor LY363196, CSE- and C5a-mediated IL-8 release was not inhibited.	ly363196	73-81	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
11813828-9	2002	However, with higher concentrations of LY363196 (&gt;600 nM), which exceeds the IC50 for PKCbeta greater than 100 fold, CSE- and C5a-mediated IL-8 release was significantly suppressed.	ly363196	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
11813828-7	2002	Preincubation with 10 microM TMB-8 (an intracellular calcium sequester) also significantly suppressed IL-8 release in CSE- and C5a-treated HBEC, suggesting that intracellular calcium is required for CSE- and C5a-mediated IL-8 release.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	29-34	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
11813828-10	2002	Preincubation of HBEC with 100 nM of Go 6976, a specific PKCalpha inhibitor, significantly inhibited CSE- and C5a-mediated stimulation of IL-8 release.	Go 6976	37-44	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
11813828-11	2002	CONCLUSIONS: Collectively, these data suggest that PKC activators in addition to CSE augment C5a-stimulated IL-8 release from HBEC and that CSE and C5a stimulate IL-8 release in HBEC by activating the calcium-dependent PKCalpha isoform.	Calcium	201-208	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
11813828-7	2002	Preincubation with 10 microM TMB-8 (an intracellular calcium sequester) also significantly suppressed IL-8 release in CSE- and C5a-treated HBEC, suggesting that intracellular calcium is required for CSE- and C5a-mediated IL-8 release.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	29-34	C-X-C motif chemokine ligand 8	Homo sapiens	221-225
11813828-7	2002	Preincubation with 10 microM TMB-8 (an intracellular calcium sequester) also significantly suppressed IL-8 release in CSE- and C5a-treated HBEC, suggesting that intracellular calcium is required for CSE- and C5a-mediated IL-8 release.	Calcium	53-60	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
11857718-10	2002	This in turn indicates that the reaction pathway involving only the loss of one or multiple units of BF(3), favored for the (NaBF(4))(n)Na(+) cluster series, but not for the analogous (KBF(4))(n)K(+) series, may be due to the high gas-phase stability of NaF, and relatively lower stability of KF, towards dissociation.	boron trifluoride	101-106	C-X-C motif chemokine ligand 8	Homo sapiens	254-257
12424420-3	2002	STUDY DESIGN: The IL-1beta-induced IL-6/IL-8 release of HPMC from healthy donors and from patients with end-stage renal disease (ESRD) were measured before the start of chronic peritoneal dialysis (PD) and during PD therapy.	hydroxypropylmethylcellulose-lactose matrix	56-60	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
12424420-12	2002	However, HPMC from uremic patients produced more IL-8 on IL-1beta stimulation than the non-uremic controls (group 2, 53.5 +/- 15.7 pg/microg; group 3, 70.5 +/- 27.3 pg/microg vs. group 1, 24.0 +/- 11.8 pg/microg).	hydroxypropylmethylcellulose-lactose matrix	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
12424420-17	2002	Not further classified serum components in uremia also enhance IL-6 and IL-8 release of HPMC.	hydroxypropylmethylcellulose-lactose matrix	88-92	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
12090783-0	2002	The selective CXCR2 antagonist SB272844 blocks interleukin-8 and growth-related oncogene-alpha-mediated inhibition of spontaneous neutrophil apoptosis.	sb272844	31-39	C-X-C motif chemokine ligand 8	Homo sapiens	47-60
12090783-3	2002	The pro-survival effect of a fixed concentration of agonist (IL-8 or Gro-alpha) on cultured neutrophils was abrogated by a selective CXCR2 antagonist SB272844 (K(D)s 253 nM and 49.9 nM in the presence of IL-8 or Gro-alpha respectively).	sb272844	150-158	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
12090783-3	2002	The pro-survival effect of a fixed concentration of agonist (IL-8 or Gro-alpha) on cultured neutrophils was abrogated by a selective CXCR2 antagonist SB272844 (K(D)s 253 nM and 49.9 nM in the presence of IL-8 or Gro-alpha respectively).	sb272844	150-158	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
12090783-5	2002	The inhibitory effect of IL-8 may in addition partly be mediated through CXCR1 as SB272844 was less potent in its ability to abrogate the anti-apoptotic effects of IL-8 when this agent was used as an agonist.	sb272844	82-90	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
12090783-5	2002	The inhibitory effect of IL-8 may in addition partly be mediated through CXCR1 as SB272844 was less potent in its ability to abrogate the anti-apoptotic effects of IL-8 when this agent was used as an agonist.	sb272844	82-90	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
12477328-4	2002	IL-8 and TNF-alpha were visualized by means of immunohistochemistry in paraffin-embedded heart valve biopsies from 6 patients with infective endocarditis who required cardiac surgery during the active phase of the infection.	Paraffin	71-79	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
15526538-6	2002	The potent proinflammatory cytokines IL-1 and TNFalpha and also IL-8 and IFNalpha,gamma stimulate cells in different tissues to release harmful proteinases and reactive oxygen species, contributing to tissue damage.	Reactive Oxygen Species	160-183	C-X-C motif chemokine ligand 8	Homo sapiens	64-81
12688521-7	2002	This IL-8 production was inhibited by catechins.	Catechin	38-47	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
11848444-8	2002	Furthermore, ELISA assays performed on the supernatant of HUVEC culture medium showed a significant increase of IL-8 for cells treated with 25-mM compared to 5-mM glucose.	Glucose	163-170	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
11751182-5	2001	Budesonide treatment did not inhibit the functional response to ozone exposure, as determined by reduction in FEV(1) and increase in total symptom score, but it significantly blunted the increase in the percentage of sputum neutrophils and interleukin-8 concentrations in the supernatant (p &lt; 0.05).	Budesonide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	240-253
11766169-4	2001	In the absence of LPS, DON at 500 or 1,000 ng/ml upregulated TNF-alpha production as early as 3 h and up to 6 h, whereas 100 to 1,000 ng/ml of DON significantly increased production of IL-6 from 3 to 24 h and IL-8 from 6 to 48 h. In cells costimulated with 0.2 microg/ml LPS, DON at 500 or 1000 ng/ml markedly superinduced TNF-alpha and IL-8 production.	DONS	143-146	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
11766169-4	2001	In the absence of LPS, DON at 500 or 1,000 ng/ml upregulated TNF-alpha production as early as 3 h and up to 6 h, whereas 100 to 1,000 ng/ml of DON significantly increased production of IL-6 from 3 to 24 h and IL-8 from 6 to 48 h. In cells costimulated with 0.2 microg/ml LPS, DON at 500 or 1000 ng/ml markedly superinduced TNF-alpha and IL-8 production.	DONS	143-146	C-X-C motif chemokine ligand 8	Homo sapiens	337-341
11766169-6	2001	Four other 8-ketotrichothecenes, fusarenon X, nivalenol, 3-acetyl DON, and 15-acetyl DON, were also capable of upregulating or suppressing TNF-alpha, IL-6, and IL-8 production at concentrations similar to that of DON.	8-ketotrichothecenes	11-31	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
11766169-6	2001	Four other 8-ketotrichothecenes, fusarenon X, nivalenol, 3-acetyl DON, and 15-acetyl DON, were also capable of upregulating or suppressing TNF-alpha, IL-6, and IL-8 production at concentrations similar to that of DON.	3-Acetyldeoxynivalenol	57-69	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
11766169-6	2001	Four other 8-ketotrichothecenes, fusarenon X, nivalenol, 3-acetyl DON, and 15-acetyl DON, were also capable of upregulating or suppressing TNF-alpha, IL-6, and IL-8 production at concentrations similar to that of DON.	ZINC33650233	75-88	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
11766169-0	2001	Differential upregulation of TNF-alpha, IL-6, and IL-8 production by deoxynivalenol (vomitoxin) and other 8-ketotrichothecenes in a human macrophage model.	deoxynivalenol	69-83	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
11766169-0	2001	Differential upregulation of TNF-alpha, IL-6, and IL-8 production by deoxynivalenol (vomitoxin) and other 8-ketotrichothecenes in a human macrophage model.	deoxynivalenol	85-94	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
11766169-0	2001	Differential upregulation of TNF-alpha, IL-6, and IL-8 production by deoxynivalenol (vomitoxin) and other 8-ketotrichothecenes in a human macrophage model.	8-ketotrichothecenes	106-126	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
11766169-4	2001	In the absence of LPS, DON at 500 or 1,000 ng/ml upregulated TNF-alpha production as early as 3 h and up to 6 h, whereas 100 to 1,000 ng/ml of DON significantly increased production of IL-6 from 3 to 24 h and IL-8 from 6 to 48 h. In cells costimulated with 0.2 microg/ml LPS, DON at 500 or 1000 ng/ml markedly superinduced TNF-alpha and IL-8 production.	DONS	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
11766169-4	2001	In the absence of LPS, DON at 500 or 1,000 ng/ml upregulated TNF-alpha production as early as 3 h and up to 6 h, whereas 100 to 1,000 ng/ml of DON significantly increased production of IL-6 from 3 to 24 h and IL-8 from 6 to 48 h. In cells costimulated with 0.2 microg/ml LPS, DON at 500 or 1000 ng/ml markedly superinduced TNF-alpha and IL-8 production.	DONS	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	337-341
11766169-4	2001	In the absence of LPS, DON at 500 or 1,000 ng/ml upregulated TNF-alpha production as early as 3 h and up to 6 h, whereas 100 to 1,000 ng/ml of DON significantly increased production of IL-6 from 3 to 24 h and IL-8 from 6 to 48 h. In cells costimulated with 0.2 microg/ml LPS, DON at 500 or 1000 ng/ml markedly superinduced TNF-alpha and IL-8 production.	DONS	143-146	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
11766169-4	2001	In the absence of LPS, DON at 500 or 1,000 ng/ml upregulated TNF-alpha production as early as 3 h and up to 6 h, whereas 100 to 1,000 ng/ml of DON significantly increased production of IL-6 from 3 to 24 h and IL-8 from 6 to 48 h. In cells costimulated with 0.2 microg/ml LPS, DON at 500 or 1000 ng/ml markedly superinduced TNF-alpha and IL-8 production.	DONS	143-146	C-X-C motif chemokine ligand 8	Homo sapiens	337-341
11716760-2	2001	Here we show that, although induction with H(2)O(2) gives rise to NF-kappa B nuclear translocation in both lymphocyte (CEM) and monocyte (U937) cells, it leads only to the production of mRNA species encoding interleukin-8 (IL-8) and macrophage inflammatory protein 1 alpha in U937 cells.	Hydrogen Peroxide	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	208-221
12005259-9	2001	Curcumin produced significant inhibition of IL-1beta and IL-8 but minimal inhibition of TNFalpha expression by preterm lung inflammatory cells at 20 uM concentrations.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
12005259-10	2001	Adult PBMC expression of IL-8 was significantly inhibited by curcumin at 20 uM concentrations.	Curcumin	61-69	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
12005259-11	2001	Therefore, curcumin inhibits pro-inflammatory cytokine production (TNFalpha, IL-1beta and IL-8) by lung inflammatory cells ex vivo.	Curcumin	11-19	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
11603585-9	2001	Fluoride ion uptakes for AH2 were 451 micromol/g NaF, 378 KF, and 318 RbF.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
11716760-2	2001	Here we show that, although induction with H(2)O(2) gives rise to NF-kappa B nuclear translocation in both lymphocyte (CEM) and monocyte (U937) cells, it leads only to the production of mRNA species encoding interleukin-8 (IL-8) and macrophage inflammatory protein 1 alpha in U937 cells.	Hydrogen Peroxide	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	223-227
11716760-5	2001	The production of IL-8 mRNA in U937 cells is inhibited by the NF-kappa B inhibitors clasto-lactacystin-beta-lactone and E-64D (l-3-trans-ethoxycarbonyloxirane-2-carbonyl-L-leucine-3-methyl amide) but requires protein synthesis de novo.	aloxistatin	120-125	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
11716760-5	2001	The production of IL-8 mRNA in U937 cells is inhibited by the NF-kappa B inhibitors clasto-lactacystin-beta-lactone and E-64D (l-3-trans-ethoxycarbonyloxirane-2-carbonyl-L-leucine-3-methyl amide) but requires protein synthesis de novo.	l-3-trans-ethoxycarbonyloxirane-2-carbonyl-l-leucine-3-methyl amide	127-194	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
11717194-3	2001	Ligation of adenosine receptors by adenosine or its related analogue, 2-chloroadenosine (2-CADO), N(6)-cyclopentyladenosine (CPA) or CGS21680 synergistically increased IL-1beta-induced IL-6 and IL-8 production.	Adenosine	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
11737075-2	2001	Furthermore, alveolar macrophages could produce IL-8 subsequent to CD44-hyaluronic acid (HA) interaction.	Hyaluronic Acid	72-87	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
11737075-2	2001	Furthermore, alveolar macrophages could produce IL-8 subsequent to CD44-hyaluronic acid (HA) interaction.	ha	89-91	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
11544106-4	2001	While it is constitutively detected in human cancer tissues and established cell lines, IL-8 expression is regulated by various tumor microenvironment factors, such as hypoxia, acidosis, nitric oxide, and cell density.	Nitric Oxide	187-199	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
11768272-7	2001	The single exception was the chain-breaking antioxidant butylated hydroxyanisole (BHA), which markedly inhibited IL-6 and IL-8 secretion, but had no effect on NF-kappaB activation.	Butylated Hydroxyanisole	56-80	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
11768272-7	2001	The single exception was the chain-breaking antioxidant butylated hydroxyanisole (BHA), which markedly inhibited IL-6 and IL-8 secretion, but had no effect on NF-kappaB activation.	Butylated Hydroxyanisole	82-85	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
11717194-3	2001	Ligation of adenosine receptors by adenosine or its related analogue, 2-chloroadenosine (2-CADO), N(6)-cyclopentyladenosine (CPA) or CGS21680 synergistically increased IL-1beta-induced IL-6 and IL-8 production.	2-Chloroadenosine	89-95	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
11717194-3	2001	Ligation of adenosine receptors by adenosine or its related analogue, 2-chloroadenosine (2-CADO), N(6)-cyclopentyladenosine (CPA) or CGS21680 synergistically increased IL-1beta-induced IL-6 and IL-8 production.	N(6)-cyclopentyladenosine	98-123	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
11717194-3	2001	Ligation of adenosine receptors by adenosine or its related analogue, 2-chloroadenosine (2-CADO), N(6)-cyclopentyladenosine (CPA) or CGS21680 synergistically increased IL-1beta-induced IL-6 and IL-8 production.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	133-141	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
11712075-9	2001	In the human colon cancer cell line HT-29, inosine dose-dependently attenuated the production of IL-8.	Inosine	43-50	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
11739559-0	2001	Src family protein tyrosine kinase signaling mediates monosodium urate crystal-induced IL-8 expression by monocytic THP-1 cells.	Uric Acid	54-70	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
11794696-2	2001	Cytochalasin B also enhanced changes in membrane potential stimulated by FMLP but inhibited those stimulated by IL-8.	Cytochalasin B	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
11794696-1	2001	Cytochalasin B, despite its potent enhancing effect on superoxide (O2-) release triggered by N-formyl-methionyl-leucyl-phenylalanine (FMLP) and many other agonists, significantly inhibited O2- release triggered by interleukin 8 (IL-8) and platelet-activating factor in human neutrophils.	Cytochalasin B	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	214-227
11794696-1	2001	Cytochalasin B, despite its potent enhancing effect on superoxide (O2-) release triggered by N-formyl-methionyl-leucyl-phenylalanine (FMLP) and many other agonists, significantly inhibited O2- release triggered by interleukin 8 (IL-8) and platelet-activating factor in human neutrophils.	Cytochalasin B	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	229-233
11739559-1	2001	Neutrophil-dependent inflammation dependent on monosodium urate (MSU) crystal-induced IL-8 expression occurs in gout.	Uric Acid	47-63	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
11739559-1	2001	Neutrophil-dependent inflammation dependent on monosodium urate (MSU) crystal-induced IL-8 expression occurs in gout.	Uric Acid	65-68	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
11739559-5	2001	IL-8 expression was attenuated more by the Src kinase inhibitor PP1 than by the p70s6k inhibitor rapamycin.	Sirolimus	97-106	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
11886504-4	2001	Activators for PPAR-alpha (WY-14,643, clofibrate) were shown to reverse ultraviolet-B-light-mediated expression of inflammatory cytokines (interleukin-6, interleukin-8).	Clofibrate	38-48	C-X-C motif chemokine ligand 8	Homo sapiens	154-167
11855746-1	2001	This study compared the effects of cholera toxin (CTX) and pertussis toxin (PTX) on the actions of sodium fluoride (NaF) and those of aluminum fluoride (AlF3) on cell proliferation and differentiation, as well as tyrosine phosphorylation level of mitogen activated protein kinase (MAPK) in human bone cells.	Sodium Fluoride	99-114	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
11855746-2	2001	NaF and AlF3 each significantly stimulated the proliferation of human TE85 osteosarcoma cells, increased cellular alkaline phosphatase (ALP) activity, and increased MAPK tyrosine phosphorylation level.	Tyrosine	170-178	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
11698167-0	2001	Analysis of interleukin-8 release from normal human epidermal keratinocytes exposed to aliphatic hydrocarbons: delivery of hydrocarbons to cell cultures via complexation with alpha-cyclodextrin.	Hydrocarbons	97-109	C-X-C motif chemokine ligand 8	Homo sapiens	12-25
11800083-10	2001	Interleukin-8 levels increased significantly after treatment in the plasma exchange group while decreasing significantly after treatment in the plasma exchange + CHDF group.	chdf	162-166	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
11698167-0	2001	Analysis of interleukin-8 release from normal human epidermal keratinocytes exposed to aliphatic hydrocarbons: delivery of hydrocarbons to cell cultures via complexation with alpha-cyclodextrin.	alpha-cyclodextrin	175-193	C-X-C motif chemokine ligand 8	Homo sapiens	12-25
11698167-3	2001	The objective of this study was to examine the effects of individual hydrocarbon components found in these fuels on IL-8 production by NHEK.	Hydrocarbons	69-80	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
11574537-9	2001	In summary, our results demonstrate that NT stimulates calcium-dependent NF-kappaB and Ras-dependent Erk pathways that mediate the release of IL-8 from non-transformed human colonocytes.	Calcium	55-62	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
11737818-17	2001	There was a significant increase in IL-1alpha and a directional increase in IL-8 levels in adult skin sites treated with the irritant, sodium lauryl sulfate, even in the absence of visible skin irritation (erythema).	Sodium Dodecyl Sulfate	135-156	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
11713107-4	2001	Whereas under basal and stimulatory conditions, the addition of DA to endothelial cells dose-dependently increased IL-8 production, the production of ENA-78 and Gro-alpha was significantly inhibited (P &lt; 0.01).	Dopamine	64-66	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
11705449-6	2001	IPDX inhibited NECA (5"-N-ethylcarboxamidoadenosine)-induced interleukin-8 secretion in human mast cells (HMC-1) with a potency close to that determined for A(2B)-mediated cAMP accumulation in HEL cells, thus confirming the role of A(2B) adenosine receptors in mediating human mast cell activation.	3-isobutyl-8-pyrrolidinoxanthine	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
11705449-6	2001	IPDX inhibited NECA (5"-N-ethylcarboxamidoadenosine)-induced interleukin-8 secretion in human mast cells (HMC-1) with a potency close to that determined for A(2B)-mediated cAMP accumulation in HEL cells, thus confirming the role of A(2B) adenosine receptors in mediating human mast cell activation.	Adenosine-5'-(N-ethylcarboxamide)	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
11705449-6	2001	IPDX inhibited NECA (5"-N-ethylcarboxamidoadenosine)-induced interleukin-8 secretion in human mast cells (HMC-1) with a potency close to that determined for A(2B)-mediated cAMP accumulation in HEL cells, thus confirming the role of A(2B) adenosine receptors in mediating human mast cell activation.	Adenosine-5'-(N-ethylcarboxamide)	21-51	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
11687440-9	2001	Differences between pre-antibiotic and follow-up cytokine/creatinine ratios were significant for IL-1 beta, IL-6, and IL-8 (P &lt; 0.01).	Creatinine	58-68	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
11687440-10	2001	Differences between pre-antibiotic and control cytokine/creatinine ratios were also significant for IL-1 beta, IL-6, and IL-8 (P &lt; 0.01).	Creatinine	56-66	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
11716205-6	2001	The number of IL-8-positive cells was higher in pSS butthe numbers of IL-4-and IL-5-positive cells were not significantly different between pSS and healthy controls.	pss	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
11741401-11	2001	ELISA assays of spent culture media showed increased protein levels of TNF-alpha and IL-8 in HMO6 cells following treatment with Abeta(25-35) or LPS.	UNII-042A8N37WH	129-134	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
11831875-5	2001	Addition of the glucocorticoid anti-inflammatory agent hydrocortisone (200-1000 ng/ml) attenuated the production of MIP-1alpha and IL-8 in PIV-infected cells while having minimal to no effect on the production of these mediators from cells infected with RSV.	Hydrocortisone	55-69	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
11692108-6	2001	A selective MAP kinase kinase inhibitor, PD98059, inhibited IL-17-induced IL-6 and IL-8.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	41-48	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
11597930-0	2001	Increased transcription of IL-8 in endothelial cells is differentially regulated by TNF-alpha and oxidized phospholipids.	Phospholipids	107-120	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
11546678-4	2001	Under these conditions, the maximum cAMP production induced by NaF and forskolin was not significantly different among selected clones, regardless of the receptor expression level.	Cyclic AMP	36-40	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
11583705-7	2001	PMPs induced interleukin-8 (IL-8), interleukin-1 beta (IL-1 beta), and tumor necrosis factor alpha (TNF alpha) production by THP-1.	pmps	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	13-26
11567778-0	2001	Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells.	Fluorides	14-22	C-X-C motif chemokine ligand 8	Homo sapiens	31-44
11567778-1	2001	Sodium fluoride (NaF) has previously been reported to induce a strong IL-8 response in human epithelial lung cells (A549) via mechanisms that seem to involve the activation of G proteins.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
11567778-1	2001	Sodium fluoride (NaF) has previously been reported to induce a strong IL-8 response in human epithelial lung cells (A549) via mechanisms that seem to involve the activation of G proteins.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
11567778-9	2001	The NaF-induced IL-8 response was weakly augmented by the PKA stimulator forskolin and the G(i) inhibitor pertussis toxin.	Colforsin	73-82	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
11567778-9	2001	The NaF-induced IL-8 response was weakly augmented by the PKA stimulator forskolin and the G(i) inhibitor pertussis toxin.	Colforsin	73-82	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
11567778-10	2001	The PKA inhibitor H89 seemed to reduce the NaF-induced IL-8 response, but the measured effect was not statistically significant.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
11567778-10	2001	The PKA inhibitor H89 seemed to reduce the NaF-induced IL-8 response, but the measured effect was not statistically significant.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
11567778-14	2001	Tyrosine kinases, Ca(2+)-linked pathways, PI-3 kinase, PKA and phosphatase inhibition seem to play no or minor roles in the fluoride-induced IL-8 response.	Fluorides	124-132	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
11749774-12	2001	After administration of methylprednisolone or aprotinin, leukocyte CD11b expression, plasma IL-6, IL-8, C-reactive protein levels, and MPO activity decreased by different extent.	Methylprednisolone	24-42	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
11594953-7	2001	Interleukin 6 and IL-8 were increased by 10 microg/mL of CsA, whereas transforming growth factor beta, PIIIP, and total protein were unaffected.	Cyclosporine	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
11583705-7	2001	PMPs induced interleukin-8 (IL-8), interleukin-1 beta (IL-1 beta), and tumor necrosis factor alpha (TNF alpha) production by THP-1.	pmps	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
11583705-8	2001	PMPs also induced IL-8, IL-1 beta, and interleukin-6 (IL-6) production by ECs.	pmps	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
11597930-7	2001	Actinomycin D experiments suggested that both Ox-PAPC and TNF-alpha regulate the expression of IL-8 at the transcriptional level.	Dactinomycin	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
11606315-0	2001	Pravastatin suppresses the interleukin-8 production induced by thrombin in human aortic endothelial cells cultured with high glucose by inhibiting the p44/42 mitogen activated protein kinase.	Pravastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
11606315-0	2001	Pravastatin suppresses the interleukin-8 production induced by thrombin in human aortic endothelial cells cultured with high glucose by inhibiting the p44/42 mitogen activated protein kinase.	Glucose	125-132	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
11606315-4	2001	Here, we examined the effect of pravastatin, one of the statins, on IL-8 synthesis induced by thrombin in human aortic endothelial cells (AoEC) cultured with high glucose concentrations.	Pravastatin	32-43	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
11606315-6	2001	Pravastatin significantly decreased the IL-8 synthesis induced by thrombin.	Pravastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
11606315-16	2001	Our results suggest that pravastatin inhibits IL-8 synthesis by blocking the ras-MAP (p44/42) kinase pathway rather than nuclear factor-kappaB.	Pravastatin	25-36	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
11606315-17	2001	Pravastatin may prevent atherosclerosis not only by lowering cholesterol levels, but also by suppressing IL-8 synthesis in AoEC through the inhibition of p44/42 MAP kinase, and this may be more beneficial in diabetic patients than in non-diabetics.	Pravastatin	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
11566077-3	2001	Studies were performed to measure the effects of fMLP on the synthesis and secretion of IL-8 and mucus by the goblet cell differentiated colon cancer cell lines HT29-MTX (methotrexate-conditioned HT29 colonic adenocarcinoma cell line) and LS174T, and to assess the effects of neutrophil-derived secretagogues on goblet cell secretion in these cell lines.	Methotrexate	171-183	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
11566077-4	2001	fMLP (0.1 microM) increased the secretion of IL-8 by 105% (P&lt;0.0001) in HT29-MTX cells and by 401% (P&lt;0.0001) in LS174T cells.	Methotrexate	80-83	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
11846989-6	2001	6-Methylcoumarine (weak P) was not cytotoxic, yet it increased IL-8 release and mRNA expression only following UVA irradiation.	6-methylcoumarine	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
11589728-4	2001	Enriched isolated skin mast cells released both TNF-alpha and IL-8 following activation with either anti-IgE, SCF, substance P, compound 48/80 or A23187.	Calcimycin	146-152	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
11591404-1	2001	OBJECTIVE: To study the effects of omega-3 and omega-6 polyunsaturated fatty acid (PUFA) on in vitro proliferation of endometrial cells and their production of the cytokine interleukin-8 (IL-8).	omega-3	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	173-186
11591404-1	2001	OBJECTIVE: To study the effects of omega-3 and omega-6 polyunsaturated fatty acid (PUFA) on in vitro proliferation of endometrial cells and their production of the cytokine interleukin-8 (IL-8).	omega-6 polyunsaturated fatty acid	47-81	C-X-C motif chemokine ligand 8	Homo sapiens	173-186
11591404-1	2001	OBJECTIVE: To study the effects of omega-3 and omega-6 polyunsaturated fatty acid (PUFA) on in vitro proliferation of endometrial cells and their production of the cytokine interleukin-8 (IL-8).	omega-6 polyunsaturated fatty acid	47-81	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
11591404-1	2001	OBJECTIVE: To study the effects of omega-3 and omega-6 polyunsaturated fatty acid (PUFA) on in vitro proliferation of endometrial cells and their production of the cytokine interleukin-8 (IL-8).	Fatty Acids, Unsaturated	83-87	C-X-C motif chemokine ligand 8	Homo sapiens	173-186
11591404-8	2001	Endometrial cells from women with endometriosis secreted higher concentrations of IL-8, especially in the presence of high omega-3:omega-6 PUFA ratios.	omega-3	123-130	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
11591404-8	2001	Endometrial cells from women with endometriosis secreted higher concentrations of IL-8, especially in the presence of high omega-3:omega-6 PUFA ratios.	omega-6 pufa	131-143	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
11699980-14	2001	Self-applied fluoride therapy should consist of the daily five-minute application of 1.1 percent NaF or APF gel (5,000 ppm of fluoride) in a custom-fitted tray.	Fluorides	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	97-100
11688002-16	2001	IL-8 levels in control patients were significantly higher compared with patients treated with aprotinin and patients treated with methylprednisolone 1 hour after CPB (p &lt; 0.05).	Methylprednisolone	130-148	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
11688002-17	2001	CONCLUSION: This study showed that methylprednisolone suppresses TNF-alpha, IL-6, and IL-8 release; however, aprotinin attenuates IL-8 release alone.	Methylprednisolone	35-53	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
11699980-15	2001	For those who cannot tolerate a tray delivery owing to gagging or nausea, a daily 0.05 percent NaF rinse (230 ppm of fluoride) for 1 minute is a less effective alternative.	Fluorides	117-125	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
11585641-5	2001	MG-132 inhibited IL-1beta-induced up-regulation of IL-1beta and IL-8 mRNA and protein but increased hypoxia-stimulated expression/release of IL-1beta and IL-8.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
11676825-8	2001	Using enzyme-linked immunosorbent assay, we assessed the effect of glybenclamide on interleukin-8 production in human dermal fibroblasts.	Glyburide	67-80	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
11676825-10	2001	Glybenclamide disabled this activation loop and significantly reduced interleukin-8.	Glyburide	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
11585641-5	2001	MG-132 inhibited IL-1beta-induced up-regulation of IL-1beta and IL-8 mRNA and protein but increased hypoxia-stimulated expression/release of IL-1beta and IL-8.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
11676825-11	2001	In human dermal fibroblasts that were stimulated with tumor necrosis factor alpha to reach high interleukin-1 expression levels, glybenclamide similarly suppressed interleukin-8.	Glyburide	129-142	C-X-C motif chemokine ligand 8	Homo sapiens	164-177
11598150-7	2001	IL-18 induces IL-8 secretion through NFkappaB because RA synovial fibroblasts pretreated with antisense to NFkappaB p65 oligonucleotide produce a mean of 44% less IL-8 compared with cells pretreated with the control sense oligonucleotide.	Oligonucleotides	120-135	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
11676825-15	2001	These results are consistent with glybenclamide preventing externalization of interleukin-1 and subsequent autocrine induction of interleukin-8 in human dermal fibroblasts.	Glyburide	34-47	C-X-C motif chemokine ligand 8	Homo sapiens	130-143
11576379-8	2001	In the ARF/HF group, a significantly positive correlation between CL PMN-priming activity and IL-8 concentrations was observed.	CHEMBL2332890	66-72	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
11598150-7	2001	IL-18 induces IL-8 secretion through NFkappaB because RA synovial fibroblasts pretreated with antisense to NFkappaB p65 oligonucleotide produce a mean of 44% less IL-8 compared with cells pretreated with the control sense oligonucleotide.	Oligonucleotides	120-135	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
11598150-7	2001	IL-18 induces IL-8 secretion through NFkappaB because RA synovial fibroblasts pretreated with antisense to NFkappaB p65 oligonucleotide produce a mean of 44% less IL-8 compared with cells pretreated with the control sense oligonucleotide.	Oligonucleotides	222-237	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
11577781-0	2001	Prostaglandin-J2 induces synthesis of interleukin-8 by endothelial cells in a PPAR-gamma-independent manner.	9-deoxy-delta-9-prostaglandin D2	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	38-51
11564889-8	2001	Finally, we show that inhibition of HDAC activity with TSA causes an increase in both basal and TNF-induced expression of the NF-kappaB-regulated interleukin-8 (IL-8) gene.	trichostatin A	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	146-159
11564889-8	2001	Finally, we show that inhibition of HDAC activity with TSA causes an increase in both basal and TNF-induced expression of the NF-kappaB-regulated interleukin-8 (IL-8) gene.	trichostatin A	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
11564889-9	2001	Similar to the wild-type integrated NF-kappaB-dependent reporter, ChIP assays showed that TSA treatment resulted in hyperacetylation of the IL-8 promoter.	trichostatin A	90-93	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
11713368-10	2001	High IL-8 levels negatively correlated with PaO2/FiO2 (r = -0.56, P &lt; 0.001).	pao2	44-48	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
11713368-10	2001	High IL-8 levels negatively correlated with PaO2/FiO2 (r = -0.56, P &lt; 0.001).	fio2	49-53	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
11719173-5	2001	In stepwise multiple regression analysis, maximum IL-8 values were significantly correlated with maximum TNF-alpha values within post-ROSC 24 h, with the total dose of administered epinephrine and with peripheral neutrophil counts.	Epinephrine	181-192	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
11719173-6	2001	It is especially noteworthy that the total dose of epinephrine administered during and after resuscitation markedly influenced the elevation of serum IL-8 after ROSC.	Epinephrine	51-62	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
11719173-7	2001	The increases in serum IL-8 induced by excessive administration of epinephrine might be harmful in the ROSC-patients resuscitated after CPA.	Epinephrine	67-78	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
11577781-2	2001	We investigated the influence of PPARgamma-ligands, 15-deoxy-delta12,14 prostaglandin-J2 (15d-PGJ2), and ciglitazone, on the generation of interleukin-8 (IL-8) by the human microvascular endothelial cell line (HMEC- 1).	9-deoxy-delta-9-prostaglandin D2	72-88	C-X-C motif chemokine ligand 8	Homo sapiens	139-152
11577781-2	2001	We investigated the influence of PPARgamma-ligands, 15-deoxy-delta12,14 prostaglandin-J2 (15d-PGJ2), and ciglitazone, on the generation of interleukin-8 (IL-8) by the human microvascular endothelial cell line (HMEC- 1).	15-deoxy-delta(12,14)-prostaglandin J2	90-98	C-X-C motif chemokine ligand 8	Homo sapiens	139-152
11577781-2	2001	We investigated the influence of PPARgamma-ligands, 15-deoxy-delta12,14 prostaglandin-J2 (15d-PGJ2), and ciglitazone, on the generation of interleukin-8 (IL-8) by the human microvascular endothelial cell line (HMEC- 1).	ciglitazone	105-116	C-X-C motif chemokine ligand 8	Homo sapiens	139-152
11577781-7	2001	15d-PGJ2 potently and dose-dependently increased both the steady-state and LPS-induced generation of IL-8 mRNA and IL-8 protein.	15-deoxy-delta(12,14)-prostaglandin J2	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
11577781-7	2001	15d-PGJ2 potently and dose-dependently increased both the steady-state and LPS-induced generation of IL-8 mRNA and IL-8 protein.	15-deoxy-delta(12,14)-prostaglandin J2	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
11577781-9	2001	We conclude, that 15d-PGJ2 is a potent inducer of IL-8 production and can be a mediator of inflammatory response, but this effect is independent of PPARgamma activation.	15-deoxy-delta(12,14)-prostaglandin J2	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
11461907-4	2001	The data show that stimulation of 16HBE14o(-) cells with NE induced IL-8 protein production and gene expression.	16hbe14o	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
11517438-2	2001	Exposure of HUVECs to ethanol (0.01%-1%) dose-dependently inhibited (by 12%-27%) the release of stem cell factor, granulocyte-macrophage and granulocyte colony-stimulating factors (CSFs), or interleukin (IL)-8, but not of macrophage CSF triggered by lipopolysaccharide (LPS) or IL-1.	Ethanol	22-29	C-X-C motif chemokine ligand 8	Homo sapiens	191-209
11587995-5	2001	After budesonide treatment there was a significant decrease in the number of submucosal cells staining for total NF-kappaB, granulocyte macrophage colony-stimulating factor (GM-CSF) and tumor necrosis factor-alpha (TNF-alpha), accompanied by a significant decrease in mucosal eosinophils and expression of vascular cell adhesion molecule-1 (VCAM-1) in the endothelium and interleukin-8 (IL-8) in the epithelium.	Budesonide	6-16	C-X-C motif chemokine ligand 8	Homo sapiens	372-385
11551520-5	2001	In the present study, we demonstrated that cepharanthine suppresses the production of inflammatory cytokines and a chemokine, i.e. TNF-alpha, interleukin (IL)-1beta, IL-6, and IL-8, in human monocytic cell cultures, including primary monocyte/macrophage cultures.	cepharanthine	43-56	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
11587995-5	2001	After budesonide treatment there was a significant decrease in the number of submucosal cells staining for total NF-kappaB, granulocyte macrophage colony-stimulating factor (GM-CSF) and tumor necrosis factor-alpha (TNF-alpha), accompanied by a significant decrease in mucosal eosinophils and expression of vascular cell adhesion molecule-1 (VCAM-1) in the endothelium and interleukin-8 (IL-8) in the epithelium.	Budesonide	6-16	C-X-C motif chemokine ligand 8	Homo sapiens	387-391
11535839-1	2001	The Plasmodium falciparum translationally controlled tumor protein (TCTP) is a homolog of the mammalian histamine-releasing factor (HRF), which causes histamine release from human basophils and IL-8 secretion from eosinophils.	Histamine	104-113	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
11504702-3	2001	Exposure of freshly isolated human neutrophils to acrolein markedly inhibited spontaneous neutrophil apoptosis as indicated by loss of membrane asymmetry and DNA fragmentation and induced increased neutrophil production of the chemokine interleukin-8 (IL-8).	Acrolein	50-58	C-X-C motif chemokine ligand 8	Homo sapiens	237-250
11563737-10	2001	If NaF is not used as a preservative, GHB is produced as an artifact.	N-Methyl-3,4-methylenedioxyamphetamine	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	3-6
11500171-6	2001	Cerivastatin [10 pM to 100 microM] decreased leukocyte chemotaxis towards interleukin-8 or RANTES.	cerivastatin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
11546726-7	2001	Furthermore, ketamine isomers at concentrations exceeding 500 microM significantly suppressed SEB-induced IL-8 production.	Ketamine	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
11546726-9	2001	CONCLUSION: This study demonstrated that ketamine isomers suppressed SEB-induced TNF-, IL-6, and IL-8 production in human whole blood.	Ketamine	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
11557916-0	2001	Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents.	Acetaminophen	43-56	C-X-C motif chemokine ligand 8	Homo sapiens	19-32
11557916-12	2001	CONCLUSIONS: Interleukin 8 elevation in patients with acetaminophen hepatotoxicity corresponds with other common clinical measures that are predictive of hepatocellular injury.	Acetaminophen	54-67	C-X-C motif chemokine ligand 8	Homo sapiens	13-26
11597034-8	2001	RANTES and IL-8 had more abundant gene messages in PGN.	pgn	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
11520766-10	2001	During the second 10-20 day phase, the level of both IL-6 and IL-8 decreased significantly in the presence of pentoxifylline, the relation between these two cytokines being the inverse of that observed in the absence of the drug.	Pentoxifylline	110-124	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
11520766-12	2001	CONCLUSION: The addition of pentoxifylline to organ culture media leads, ultimately, to a suppression of IL-6 and IL-8 secretion by corneal tissue.	Pentoxifylline	28-42	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
11555581-5	2001	IL-8 antisense oligonucleotides specifically reduced IL-8 mRNA and protein levels and inhibited KS cell growth in a dose-dependent manner.	Oligonucleotides	15-31	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
11555581-5	2001	IL-8 antisense oligonucleotides specifically reduced IL-8 mRNA and protein levels and inhibited KS cell growth in a dose-dependent manner.	Oligonucleotides	15-31	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
11531942-7	2001	IL-8 mRNA accumulation was detected by Northern blot analysis within 2 h of stimulation by the immune complexes and was enhanced by the addition of cycloheximide.	Cycloheximide	148-161	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
11531942-8	2001	Secretion of IL-8 by C1q-IC stimulated HUVEC was completely blocked by the PTK inhibitor, genistein or the MAPK inhibitor, UO126.	Genistein	90-99	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
11531942-8	2001	Secretion of IL-8 by C1q-IC stimulated HUVEC was completely blocked by the PTK inhibitor, genistein or the MAPK inhibitor, UO126.	U 0126	123-128	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
11504702-3	2001	Exposure of freshly isolated human neutrophils to acrolein markedly inhibited spontaneous neutrophil apoptosis as indicated by loss of membrane asymmetry and DNA fragmentation and induced increased neutrophil production of the chemokine interleukin-8 (IL-8).	Acrolein	50-58	C-X-C motif chemokine ligand 8	Homo sapiens	252-256
11509278-7	2001	Our additional finding was that there was a negative correlation between IL-8 level and hemoglobin saturation with oxygen in coronary sinus blood 10 min after coronary reperfusion.	Oxygen	115-121	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
11504702-4	2001	Acrolein (1--50 microM) was found to induce marked activation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinases (MAPKs), and inhibition of p38 MAPK activation by SB-203580 prevented acrolein-induced IL-8 release.	Acrolein	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
12604011-3	2001	Particular hydroxylation patterns of the B ring of the flavones permit them to inhibit histamine, tryptase, interleukin-6 and interleukin-8 release from human umbilical-cord derived cultured mast cells, as well as from macrophages.	Flavones	55-63	C-X-C motif chemokine ligand 8	Homo sapiens	126-139
11589350-8	2001	PBNs are spontaneously activated and undergo a greater motility response to IL-8 and Gro-alpha in CFA.	pbns	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
11562079-1	2001	We show that radicicol, an anti-fungal agent, inhibits interleukin-8 (IL-8) production by the human monocyte line THP-1 in response to phorbol-12-myristate-13-acetate/lipopolysaccharide (PMA/LPS).	Tetradecanoylphorbol Acetate	187-190	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
11562079-8	2001	PD98059 and SB203580, known as a specific inhibitor of MEKI and p38 kinase, respectively, inhibited IL-8 gene expression showing that both of the kinase pathways are involved in IL-8 regulation in human monocytes.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
11562079-8	2001	PD98059 and SB203580, known as a specific inhibitor of MEKI and p38 kinase, respectively, inhibited IL-8 gene expression showing that both of the kinase pathways are involved in IL-8 regulation in human monocytes.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
11562079-8	2001	PD98059 and SB203580, known as a specific inhibitor of MEKI and p38 kinase, respectively, inhibited IL-8 gene expression showing that both of the kinase pathways are involved in IL-8 regulation in human monocytes.	SB 203580	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
11562079-8	2001	PD98059 and SB203580, known as a specific inhibitor of MEKI and p38 kinase, respectively, inhibited IL-8 gene expression showing that both of the kinase pathways are involved in IL-8 regulation in human monocytes.	SB 203580	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
11562079-9	2001	Collectively, this series of experiments indicates that radicicol inhibits IL-8 gene expression by blocking ERK1/2 and p38 signaling.	monorden	56-65	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
11562079-0	2001	Suppression of IL-8 gene expression by radicicol is mediated through the inhibition of ERK1/2 and p38 signaling and negative regulation of NF-kappaB and AP-1.	monorden	39-48	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
11562079-1	2001	We show that radicicol, an anti-fungal agent, inhibits interleukin-8 (IL-8) production by the human monocyte line THP-1 in response to phorbol-12-myristate-13-acetate/lipopolysaccharide (PMA/LPS).	monorden	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	55-68
11562079-1	2001	We show that radicicol, an anti-fungal agent, inhibits interleukin-8 (IL-8) production by the human monocyte line THP-1 in response to phorbol-12-myristate-13-acetate/lipopolysaccharide (PMA/LPS).	monorden	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
11562079-1	2001	We show that radicicol, an anti-fungal agent, inhibits interleukin-8 (IL-8) production by the human monocyte line THP-1 in response to phorbol-12-myristate-13-acetate/lipopolysaccharide (PMA/LPS).	Tetradecanoylphorbol Acetate	135-166	C-X-C motif chemokine ligand 8	Homo sapiens	55-68
11562079-1	2001	We show that radicicol, an anti-fungal agent, inhibits interleukin-8 (IL-8) production by the human monocyte line THP-1 in response to phorbol-12-myristate-13-acetate/lipopolysaccharide (PMA/LPS).	Tetradecanoylphorbol Acetate	135-166	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
11595074-7	2001	The pretreatment with interferon (IFN)-gamma markedly enhanced the effects of Fas Ag stimulation; IFN-gamma pretreatment and Fas Ag stimulation synergistically induced not only apoptosis but also IL-8 and MCP-1 secretion.	ammonium ferrous sulfate	125-128	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
11527985-4	2001	However, dieldrin was found to increase human neutrophil superoxide production, RNA synthesis, and proinflammatory cytokine interleukin-8 production.	Dieldrin	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	124-137
11595074-7	2001	The pretreatment with interferon (IFN)-gamma markedly enhanced the effects of Fas Ag stimulation; IFN-gamma pretreatment and Fas Ag stimulation synergistically induced not only apoptosis but also IL-8 and MCP-1 secretion.	ammonium ferrous sulfate	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
11527994-4	2001	Actinomycin D at the beginning of culture inhibited IL-8 mRNA induction, whereas late addition affected IL-8 transcript stability, suggesting gene transcription involvement.	Dactinomycin	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
11509634-0	2001	Fibrinogen induces IL-8 synthesis in human neutrophils stimulated with formyl-methionyl-leucyl-phenylalanine or leukotriene B(4).	Leukotriene B4	112-125	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
11522371-8	2001	In summary, other mechanisms than particle-induced ROS formation seem to be responsible for the differential induction of IL-8.	Reactive Oxygen Species	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
11527995-4	2001	As a first step, we have studied regulation of interleukin (IL) 8 gene expression after interaction with zymosan or latex.	Zymosan	105-112	C-X-C motif chemokine ligand 8	Homo sapiens	47-65
11527995-5	2001	IL-8 secretion was consistently one- or twofold higher after incubation with zymosan than with latex.	Zymosan	77-84	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
11527995-8	2001	The NFkappaB inhibitor gliotoxin abrogated zymosan-induced IL-8 synthesis in peripheral blood monocytes, further demonstrating that the induction of IL-8 mRNA by zymosan is NFkappaB dependent.	Gliotoxin	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
11527995-8	2001	The NFkappaB inhibitor gliotoxin abrogated zymosan-induced IL-8 synthesis in peripheral blood monocytes, further demonstrating that the induction of IL-8 mRNA by zymosan is NFkappaB dependent.	Gliotoxin	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
11527995-8	2001	The NFkappaB inhibitor gliotoxin abrogated zymosan-induced IL-8 synthesis in peripheral blood monocytes, further demonstrating that the induction of IL-8 mRNA by zymosan is NFkappaB dependent.	Zymosan	43-50	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
11527995-8	2001	The NFkappaB inhibitor gliotoxin abrogated zymosan-induced IL-8 synthesis in peripheral blood monocytes, further demonstrating that the induction of IL-8 mRNA by zymosan is NFkappaB dependent.	Zymosan	43-50	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
11527995-8	2001	The NFkappaB inhibitor gliotoxin abrogated zymosan-induced IL-8 synthesis in peripheral blood monocytes, further demonstrating that the induction of IL-8 mRNA by zymosan is NFkappaB dependent.	Zymosan	162-169	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
11527995-8	2001	The NFkappaB inhibitor gliotoxin abrogated zymosan-induced IL-8 synthesis in peripheral blood monocytes, further demonstrating that the induction of IL-8 mRNA by zymosan is NFkappaB dependent.	Zymosan	162-169	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
11527995-9	2001	SB203580 inhibition of the p38 mitogen-activated protein kinase (MAPK) pathway significantly decreased zymosan-induced IL-8 mRNA accumulation.	SB 203580	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
11527995-9	2001	SB203580 inhibition of the p38 mitogen-activated protein kinase (MAPK) pathway significantly decreased zymosan-induced IL-8 mRNA accumulation.	Zymosan	103-110	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
11527995-11	2001	These data indicate that p38 MAPK and NFkappaB are critical in controlling zymosan-induced IL-8 secretion.	Zymosan	75-82	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
11535888-13	2001	At 40 minutes, IL-8 and GROalpha significantly inhibited TNFalpha adherence-dependent peroxide production in normal neutrophils (35% +/- 4% and 45% +/- 3%, respectively; p &lt; 0.05).	Peroxides	86-94	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
11517293-0	2001	Ectopic endometrial cells express high concentrations of interleukin (IL)-8 in vivo regardless of the menstrual cycle phase and respond to oestradiol by up-regulating IL-1-induced IL-8 expression in vitro.	Estradiol	139-149	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
11517293-7	2001	Furthermore, this study provides evidence that oestradiol indirectly up-regulates the expression by ectopic endometrial cells of IL-8, a cytokine endowed with neutrophil chemotactic and angiogenic properties.	Estradiol	47-57	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
12536723-9	2001	CONCLUSION: Establishment of cultured HPMCs model will provide the basis of the research in preventment of peritoneal fibrosis and roles of IL-8 in peritoneal dialysis.	hpmcs	38-43	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
11672576-8	2001	In conclusion, the activation of neutrophils with zymosan leads to the activation of PAF receptors and this is followed by activation of CD11/CD18, phagocytosis of zymosan particles and subsequent interleukin-8 release.	Zymosan	50-57	C-X-C motif chemokine ligand 8	Homo sapiens	197-210
12536733-0	2001	[Effects of katamine on cardiopulmonary bypass-induced interleukin-6 and interleukin-8 response and its significance].	katamine	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	73-86
12536733-1	2001	OBJECTIVE: To investigate the effects of ketamine on cardiopulmonary bypass-induced IL-6 and IL-8 response.	Ketamine	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
12536733-6	2001	CONCLUSIONS: Ketamine is effective to reduce cardiopulmonary bypass-induces IL-6 and IL-8 response and protect reperfusion myocardium.	Ketamine	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
11493478-0	2001	Antibodies from patients with heparin-induced thrombocytopenia stimulate monocytic cells to express tissue factor and secrete interleukin-8.	Heparin	30-37	C-X-C motif chemokine ligand 8	Homo sapiens	126-139
11521757-0	2001	Endogenous nitric oxide inhibits neutrophil adherence to lung epithelial cells to modulate interleukin-8 release.	Nitric Oxide	11-23	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
11521757-12	2001	In conclusion, endogenous nitric oxide may play a role in preventing neutrophil adherence to lung epithelial cells, thus modulating concomitant IL-8 release.	Nitric Oxide	26-38	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
11509327-7	2001	Pretreatment with N-acetyl-cysteine (NAC) (1 to 10 mM) or glutathione (1 to 10 mM) inhibited TNF-alpha-induced activation of NF-kappa B transcriptional activity and IL-8 promoter-mediated reporter gene expression.	Acetylcysteine	18-35	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
11435224-4	2001	The mitogen-activated protein kinase/ERK kinase (MEK) activity inhibitor PD-98059 significantly abolished IL-8 released in response to Utah Valley PM, as did the epidermal growth factor (EGF) receptor kinase inhibitor AG-1478.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	73-81	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
11435224-7	2001	These data demonstrate that Utah Valley PM can induce IL-8 expression partially through the activation of the EGF receptor signaling.	utah valley pm	28-42	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
11509327-7	2001	Pretreatment with N-acetyl-cysteine (NAC) (1 to 10 mM) or glutathione (1 to 10 mM) inhibited TNF-alpha-induced activation of NF-kappa B transcriptional activity and IL-8 promoter-mediated reporter gene expression.	Acetylcysteine	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
11509327-7	2001	Pretreatment with N-acetyl-cysteine (NAC) (1 to 10 mM) or glutathione (1 to 10 mM) inhibited TNF-alpha-induced activation of NF-kappa B transcriptional activity and IL-8 promoter-mediated reporter gene expression.	Glutathione	58-69	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
11591115-9	2001	Together, these studies are the first to demonstrate that BCG-induced IL-8 secretion by human monocytes appears to be mediated by intracellular Ca(2+) and is NF-kappaB-dependent and at the same time suggest that production of IL-8 in response to M. bovis BCG can contribute to the initial local and systemic inflammatory response in human tuberculosis.	bcg	255-258	C-X-C motif chemokine ligand 8	Homo sapiens	226-230
11468165-5	2001	Using the selective p38 MAPK inhibitor SB203580, there was a significant decrease in thrombin-induced interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) protein production and messenger RNA steady-state levels.	SB 203580	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	102-115
11468165-5	2001	Using the selective p38 MAPK inhibitor SB203580, there was a significant decrease in thrombin-induced interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) protein production and messenger RNA steady-state levels.	SB 203580	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
11468165-6	2001	In addition, SB203580 decreased IL-8 and MCP-1 production induced by the thrombin receptor-1 agonist peptide (TRAP), suggesting functional links between the thrombin G protein-coupled receptor and the p38 MAPK pathway.	SB 203580	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
11591115-2	2001	Because the mechanisms through which Mycobacterium bovis Calmette-Guerin (BCG) induces IL-8 secretion are unknown, the aim of the present study was to characterize the nature of IL-8 production induced by BCG in human monocytes.	bcg	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
11591115-2	2001	Because the mechanisms through which Mycobacterium bovis Calmette-Guerin (BCG) induces IL-8 secretion are unknown, the aim of the present study was to characterize the nature of IL-8 production induced by BCG in human monocytes.	bcg	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
11591115-2	2001	Because the mechanisms through which Mycobacterium bovis Calmette-Guerin (BCG) induces IL-8 secretion are unknown, the aim of the present study was to characterize the nature of IL-8 production induced by BCG in human monocytes.	bcg	205-208	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	U 0126	19-24	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	U 0126	19-24	C-X-C motif chemokine ligand 8	Homo sapiens	234-238
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	234-238
11591115-3	2001	In this study, we found that the induction of IL-8 synthesis was dose- and time-dependent after stimulation with BCG.	bcg	113-116	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
11511305-11	2001	These data suggest that 17beta-estradiol, progesterone, and dihydrotestosterone suppress the growth of melanoma by inhibiting interleukin-8 production in a receptor-dependent manner.	Progesterone	42-54	C-X-C motif chemokine ligand 8	Homo sapiens	126-139
11591115-5	2001	We also determined that BCG-induced IL-8 secretion occurs through a mechanism that requires intracellular calcium and likely involves a calmodulin-sensitive step.	bcg	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
11591115-5	2001	We also determined that BCG-induced IL-8 secretion occurs through a mechanism that requires intracellular calcium and likely involves a calmodulin-sensitive step.	Calcium	106-113	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
11591115-6	2001	Interestingly, BCG-induced secretion of IL-8 from human monocytes resulted from transcriptional up-regulation of the IL-8 gene.	bcg	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
11591115-6	2001	Interestingly, BCG-induced secretion of IL-8 from human monocytes resulted from transcriptional up-regulation of the IL-8 gene.	bcg	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
11591115-9	2001	Together, these studies are the first to demonstrate that BCG-induced IL-8 secretion by human monocytes appears to be mediated by intracellular Ca(2+) and is NF-kappaB-dependent and at the same time suggest that production of IL-8 in response to M. bovis BCG can contribute to the initial local and systemic inflammatory response in human tuberculosis.	bcg	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
11591115-9	2001	Together, these studies are the first to demonstrate that BCG-induced IL-8 secretion by human monocytes appears to be mediated by intracellular Ca(2+) and is NF-kappaB-dependent and at the same time suggest that production of IL-8 in response to M. bovis BCG can contribute to the initial local and systemic inflammatory response in human tuberculosis.	bcg	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	226-230
11591115-9	2001	Together, these studies are the first to demonstrate that BCG-induced IL-8 secretion by human monocytes appears to be mediated by intracellular Ca(2+) and is NF-kappaB-dependent and at the same time suggest that production of IL-8 in response to M. bovis BCG can contribute to the initial local and systemic inflammatory response in human tuberculosis.	bcg	255-258	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
11447173-4	2001	PGP induced a high level of interleukin-8 production at doses of 100 ng/ml and higher in OCT-treated THP-1 cells compared with Salmonella LPS, and the production was significantly inhibited by anti-CD14 and anti-TLR2 but not anti-TLR4 antibodies.	pgp	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	28-41
11511305-0	2001	17beta-estradiol, progesterone, and dihydrotestosterone suppress the growth of human melanoma by inhibiting interleukin-8 production.	Estradiol	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	108-121
11511305-0	2001	17beta-estradiol, progesterone, and dihydrotestosterone suppress the growth of human melanoma by inhibiting interleukin-8 production.	Progesterone	18-30	C-X-C motif chemokine ligand 8	Homo sapiens	108-121
11511305-0	2001	17beta-estradiol, progesterone, and dihydrotestosterone suppress the growth of human melanoma by inhibiting interleukin-8 production.	Dihydrotestosterone	36-55	C-X-C motif chemokine ligand 8	Homo sapiens	108-121
11511305-11	2001	These data suggest that 17beta-estradiol, progesterone, and dihydrotestosterone suppress the growth of melanoma by inhibiting interleukin-8 production in a receptor-dependent manner.	Estradiol	24-40	C-X-C motif chemokine ligand 8	Homo sapiens	126-139
11461774-2	2001	We have previously reported that fluoride (NaF) induces apoptosis in HL-60 cells by caspase-3 activation.	Fluorides	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
11454909-0	2001	Rebamipide inhibits ceramide-induced interleukin-8 production in Kato III human gastric cancer cells.	rebamipide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
11454909-0	2001	Rebamipide inhibits ceramide-induced interleukin-8 production in Kato III human gastric cancer cells.	Ceramides	20-28	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
11454909-3	2001	We have recently reported that H. pylori-dependent ceramide production may activate nuclear factor-kappaB and mediate interleukin-8 expression in human gastric cancer cell lines.	Ceramides	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	118-131
11511305-11	2001	These data suggest that 17beta-estradiol, progesterone, and dihydrotestosterone suppress the growth of melanoma by inhibiting interleukin-8 production in a receptor-dependent manner.	Dihydrotestosterone	60-79	C-X-C motif chemokine ligand 8	Homo sapiens	126-139
11454909-4	2001	In this study, we evaluated the effect of rebamipide, an antigastritis and antiulcer agent, on H. pylori-dependent ceramide production and subsequent interleukin-8 expression in Kato III cells.	rebamipide	42-52	C-X-C motif chemokine ligand 8	Homo sapiens	150-163
11454909-5	2001	Rebamipide inhibited ceramide-induced interleukin-8 expression in a dose-dependent manner.	rebamipide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	38-51
11511306-0	2001	Gangliosides GD1b, GT1b, and GQ1b suppress the growth of human melanoma by inhibiting interleukin-8 production: the inhibition of adenylate cyclase.	Gangliosides	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	86-99
11454909-5	2001	Rebamipide inhibited ceramide-induced interleukin-8 expression in a dose-dependent manner.	Ceramides	21-29	C-X-C motif chemokine ligand 8	Homo sapiens	38-51
11454909-6	2001	Rebamipide decreased the ceramide-induced increase of the interleukin-8 mRNA level as assessed by Northern blotting.	rebamipide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	58-71
11511306-8	2001	Cyclic AMP analog dibutyryl cAMP counteracted GD1b, GT1b, and GQ1b-induced inhibition of interleukin-8 production at the levels of protein secretion, mRNA expression, and promoter activity.	Cyclic AMP	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	89-102
11454909-6	2001	Rebamipide decreased the ceramide-induced increase of the interleukin-8 mRNA level as assessed by Northern blotting.	Ceramides	25-33	C-X-C motif chemokine ligand 8	Homo sapiens	58-71
11454909-7	2001	Rebamipide suppressed interleukin-8 gene transcription and nuclear factor-kappaB-dependent transcriptional activity as assessed by luciferase assay.	rebamipide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	22-35
11511306-8	2001	Cyclic AMP analog dibutyryl cAMP counteracted GD1b, GT1b, and GQ1b-induced inhibition of interleukin-8 production at the levels of protein secretion, mRNA expression, and promoter activity.	Cyclic AMP	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	89-102
11349132-0	2001	P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide.	Uridine Diphosphate	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	45-58
11525435-13	2001	Similar effects were seen when IL-8 production was evaluated following HGF stimulation with high doses of nicotine and E. coli LPS or P gingivalis LPS.	Nicotine	106-114	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
11525435-14	2001	CONCLUSIONS: These results demonstrate that nicotine by itself can stimulate HGF IL-6 and IL-8 production.	Nicotine	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
11495082-9	2001	The concentrations of recombinant (r)-IL-8, which covered the levels of activity detected in individual organ cultures or cell cultures of fractionated mucosal cells, could induce chemotactic migration and superoxide anion generation in neutrophils in vitro, and r-GROalpha had synergistic effects on r-IL-8-induced neutrophil activation.	Superoxides	206-222	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
11349132-8	2001	P2 antagonists or apyrase, an enzyme which hydrolyzes nucleotides including UDP, inhibit IL-8 production induced by lipopolysaccharide but not by other stimuli.	Uridine Diphosphate	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
11349132-5	2001	P2 receptor antagonists or P2Y(6) antisense oligonucleotides inhibit IL-8 release induced by UDP.	Oligonucleotides	44-60	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
11349132-9	2001	Furthermore, IL-8 gene expression activated by lipopolysaccharide is enhanced by P2Y(6) overexpression and inhibited by P2Y(6) antisense oligonucleotides.	Oligonucleotides	137-153	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
11349132-10	2001	Thus, UDP activates IL-8 production via P2Y(6) in monocytic cells.	Uridine Diphosphate	6-9	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
11349132-5	2001	P2 receptor antagonists or P2Y(6) antisense oligonucleotides inhibit IL-8 release induced by UDP.	Uridine Diphosphate	93-96	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
11349132-6	2001	Furthermore, UDP specifically activated IL-8 production in astrocytoma 1321N1 cells transfected with human P2Y(6).	Uridine Diphosphate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
11446882-0	2001	Medium-chain fatty acids stimulate interleukin-8 production in Caco-2 cells with different mechanisms from long-chain fatty acids.	medium-chain fatty acids	0-24	C-X-C motif chemokine ligand 8	Homo sapiens	35-48
11512674-0	2001	Hyaluronan fragments induce the synthesis of MCP-1 and IL-8 in cultured human peritoneal mesothelial cells.	Hyaluronic Acid	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
11512674-2	2001	In this study we investigated the effect of experimentally generated hyaluronan (HA) fragments, degradation products of the extracellular matrix component hyaluronan, which accumulate at inflammatory sites, on the expression of MCP-1 and IL-8 in cultured HMC.	Hyaluronic Acid	69-79	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
11512674-2	2001	In this study we investigated the effect of experimentally generated hyaluronan (HA) fragments, degradation products of the extracellular matrix component hyaluronan, which accumulate at inflammatory sites, on the expression of MCP-1 and IL-8 in cultured HMC.	Hyaluronic Acid	155-165	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
11428868-5	2001	The induced IL-8 and MCP-1 mRNA and proteins were partially suppressed by U0126, a specific MEK inhibitor, and by SB202190, a selective p38 inhibitor.	U 0126	74-79	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
11428868-5	2001	The induced IL-8 and MCP-1 mRNA and proteins were partially suppressed by U0126, a specific MEK inhibitor, and by SB202190, a selective p38 inhibitor.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	114-122	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
11472980-0	2001	Geldanamycin inhibits NF-kappaB activation and interleukin-8 gene expression in cultured human respiratory epithelium.	geldanamycin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	47-60
11472980-3	2001	In the current study, we investigated the effects of geldanamycin on interleukin (IL)-8 gene expression and nuclear factor (NF)-kappaB activation.	geldanamycin	53-65	C-X-C motif chemokine ligand 8	Homo sapiens	69-87
11472980-4	2001	Geldanamycin inhibited tumor necrosis factor (TNF)-alpha-mediated IL-8 gene expression in A549 human respiratory epithelial cells as measured by enzyme-linked immunosorbent assay and Northern blot analyses.	geldanamycin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
11472980-5	2001	In cells transiently transfected with an IL-8 promoter-luciferase reporter plasmid, geldanamycin inhibited TNF-alpha-mediated luciferase activity.	geldanamycin	84-96	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
11472980-9	2001	These results demonstrate that geldanamycin inhibits TNF-alpha-mediated IL-8 gene expression in A549 cells by inhibiting activation of the IL-8 promoter.	geldanamycin	31-43	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
11472980-9	2001	These results demonstrate that geldanamycin inhibits TNF-alpha-mediated IL-8 gene expression in A549 cells by inhibiting activation of the IL-8 promoter.	geldanamycin	31-43	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
11418672-0	2001	IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2.	N-(3-oxododecanoyl)homoserine lactone	104-140	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
11446882-0	2001	Medium-chain fatty acids stimulate interleukin-8 production in Caco-2 cells with different mechanisms from long-chain fatty acids.	long-chain fatty acids	107-129	C-X-C motif chemokine ligand 8	Homo sapiens	35-48
11446882-2	2001	We investigated the effect of fatty acids on interleukin (IL)-8 production in a human intestinal epithelial cell line (Caco-2).	Fatty Acids	30-41	C-X-C motif chemokine ligand 8	Homo sapiens	45-63
11798616-10	2001	The levels of IL-8 also increased in HPMC stimulated with TNFalpha(P &lt; 0.01).	hydroxypropylmethylcellulose-lactose matrix	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
11478413-7	2001	Tracheal concentrations of IL-8 and MCP-1 were significantly increased in infants who developed BPD (IL-8: P=0.0001; MCP-1: P&lt;0.001, analysis of variance) and correlated with duration of mechanical ventilation and oxygen treatment.	Oxygen	217-223	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
11506748-0	2001	Regulation of interleukin-8 expression by nitric oxide in human pancreatic adenocarcinoma.	Nitric Oxide	42-54	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
11506748-1	2001	The regulation of interleukin-8 (IL-8) expression by nitric oxide (NO) was determined in human pancreatic cancer cell lines.	Nitric Oxide	53-65	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
11506748-1	2001	The regulation of interleukin-8 (IL-8) expression by nitric oxide (NO) was determined in human pancreatic cancer cell lines.	Nitric Oxide	53-65	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
11506748-10	2001	Incubation of FG cells with an NO donor, S-nitroso-D,L.-acetyl-penicillamine (SNAP), led to a concentration-dependent and time-dependent induction of IL-8 expression.	s-nitroso-d,l.-acetyl-penicillamine	41-76	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
11506748-10	2001	Incubation of FG cells with an NO donor, S-nitroso-D,L.-acetyl-penicillamine (SNAP), led to a concentration-dependent and time-dependent induction of IL-8 expression.	snap	78-82	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
11798616-11	2001	CONCLUSION: L-PDF inhibited proliferation of HPMC and increased levels of IL-8 and FN in the HPMC.	l-pdf	12-17	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
11282999-6	2001	Indeed, interleukin 8, a neutrophil chemoattractant, triggered a release of approximately 85% of cellular leukolysins by a process resistant to a mixture of proteinase inhibitors, including aprotinin, BB-94, pepstatin, and E64.	batimastat	201-206	C-X-C motif chemokine ligand 8	Homo sapiens	8-21
11297551-7	2001	Consistent with the observed inhibition of NF-kappaB, thalidomide blocked the cytokine-induced expression of NF-kappaB-regulated genes such as those encoding interleukin-8, TRAF1, and c-IAP2.	Thalidomide	54-65	C-X-C motif chemokine ligand 8	Homo sapiens	158-171
11282999-6	2001	Indeed, interleukin 8, a neutrophil chemoattractant, triggered a release of approximately 85% of cellular leukolysins by a process resistant to a mixture of proteinase inhibitors, including aprotinin, BB-94, pepstatin, and E64.	pepstatin	208-217	C-X-C motif chemokine ligand 8	Homo sapiens	8-21
11282999-6	2001	Indeed, interleukin 8, a neutrophil chemoattractant, triggered a release of approximately 85% of cellular leukolysins by a process resistant to a mixture of proteinase inhibitors, including aprotinin, BB-94, pepstatin, and E64.	E 64	223-226	C-X-C motif chemokine ligand 8	Homo sapiens	8-21
11404398-5	2001	A role for ATP in modulating IL-1beta-mediated inflammatory gene expression was supported further by the observation that ATP potentiated the IL-1beta-induced expression of IL-8 mRNA and protein but strongly downregulated IP-10 expression.	Adenosine Triphosphate	11-14	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
11390455-3	2001	Here we demonstrate that the 15d-PGJ2 can induce IL-8 gene expression.	15-deoxy-delta(12,14)-prostaglandin J2	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
11390455-5	2001	Furthermore, concomitant treatment of monocytes/macrophages with 15d-PGJ2 (2.5 x 10(-6) M) potentiated LPS-induced gene expression of IL-8 mRNA, but suppressed PMA-induction of IL-8 mRNA.	15-deoxy-delta(12,14)-prostaglandin J2	65-73	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
11390455-5	2001	Furthermore, concomitant treatment of monocytes/macrophages with 15d-PGJ2 (2.5 x 10(-6) M) potentiated LPS-induced gene expression of IL-8 mRNA, but suppressed PMA-induction of IL-8 mRNA.	15-deoxy-delta(12,14)-prostaglandin J2	65-73	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
11390455-6	2001	In addition, treatment of U937 and THP-1 cells with 15d-PGJ2 also resulted in induction of IL-8 gene expression.	15-deoxy-delta(12,14)-prostaglandin J2	52-60	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
11390455-7	2001	Further studies demonstrated that 15d-PGJ2 regulated IL-8 gene expression via a ligand-specific and PPARgamma-dependent pathway.	15-deoxy-delta(12,14)-prostaglandin J2	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
11404398-5	2001	A role for ATP in modulating IL-1beta-mediated inflammatory gene expression was supported further by the observation that ATP potentiated the IL-1beta-induced expression of IL-8 mRNA and protein but strongly downregulated IP-10 expression.	Adenosine Triphosphate	122-125	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
11426771-6	2001	Interleukin 1beta, interleukin 6, and interleukin 8 levels after cardiopulmonary bypass were significantly (p &lt; 0.05) lower in the colforsin group.	Colforsin	134-143	C-X-C motif chemokine ligand 8	Homo sapiens	38-51
11390343-0	2001	Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular disease.	Homocysteine	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
11390343-3	2001	METHODS AND RESULTS: Northern blot and RNase protection assays showed that DL-homocysteine induced mRNA expression of the proinflammatory cytokines monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured human aortic endothelial cells (HAECs).	DL-Homocysteine	75-90	C-X-C motif chemokine ligand 8	Homo sapiens	195-208
11390343-3	2001	METHODS AND RESULTS: Northern blot and RNase protection assays showed that DL-homocysteine induced mRNA expression of the proinflammatory cytokines monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured human aortic endothelial cells (HAECs).	DL-Homocysteine	75-90	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
11390343-7	2001	Homocysteine also triggered the release of MCP-1 and IL-8 protein from HAECs into the culture medium.	Homocysteine	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
11390343-12	2001	CONCLUSIONS: Pathophysiological levels of L-homocysteine alter endothelial cell function by upregulating MCP-1 and IL-8 expression and secretion.	Homocysteine	42-56	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
11350799-9	2001	The concentrations of interleukin-8, granulocyte colony-stimulating factor, monocyte chemoattractant protein-1, and granulocyte-macrophage colony-stimulating factor significantly increased in response to cyclophosphamide.	Cyclophosphamide	204-220	C-X-C motif chemokine ligand 8	Homo sapiens	22-35
11399048-0	2001	Nitric oxide suppresses IL-8 transcription by inhibiting c-Jun N-terminal kinase-induced AP-1 activation.	Nitric Oxide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
11415933-9	2001	In contrast, ciglitazone alone had a slight effect on cytokine-induced IL-8 secretion, but markedly inhibited IL-8 secretion from cells pretreated with IL-4.	ciglitazone	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
11415933-9	2001	In contrast, ciglitazone alone had a slight effect on cytokine-induced IL-8 secretion, but markedly inhibited IL-8 secretion from cells pretreated with IL-4.	ciglitazone	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
11422029-2	2001	OBJECTIVES: To study the effect of dimethylfumarate (DMF) on the production of the chemokines CXCL1, CXCL8, CXCL9, CXCL10 and CXCL11, formerly known as GROalpha, interleukin-8, Mig, IP-10 and IP-9/I-TAC, respectively, in human keratinocytes and peripheral blood mononuclear cells (PBMC).	Dimethyl Fumarate	35-51	C-X-C motif chemokine ligand 8	Homo sapiens	101-106
11331079-0	2001	Selective inhibition of interleukin-8-induced neutrophil chemotaxis by ketoprofen isomers.	Ketoprofen	71-81	C-X-C motif chemokine ligand 8	Homo sapiens	24-37
11331079-4	2001	Our results show that R- and S-ketoprofen, independently of their potency as PG inhibitors, proved very efficacious in selective inhibition of interleukin-8 (IL-8) chemotaxis.	r- and s-ketoprofen	22-41	C-X-C motif chemokine ligand 8	Homo sapiens	143-156
11331079-4	2001	Our results show that R- and S-ketoprofen, independently of their potency as PG inhibitors, proved very efficacious in selective inhibition of interleukin-8 (IL-8) chemotaxis.	r- and s-ketoprofen	22-41	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
11331079-5	2001	Inhibition of IL-8 chemotaxis was not restricted to ketoprofen isomer as it could be observed also with drugs belonging to different classes of NSAIDs and it was obtained at drug concentration superimposable to plasma levels after therapeutic administration in patients.	Ketoprofen	52-62	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
11331079-6	2001	Reduction of IL-8 migration by ketoprofen isomers was paralleled by selective inhibition of PMN response in terms of intracellular calcium concentration ([Ca(2+)]i) increase and extracellular signal regulated kinase(ERK)-2 activation, two intracellular mediators reported to be critical for PMN activities.	Ketoprofen	31-41	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
11331079-6	2001	Reduction of IL-8 migration by ketoprofen isomers was paralleled by selective inhibition of PMN response in terms of intracellular calcium concentration ([Ca(2+)]i) increase and extracellular signal regulated kinase(ERK)-2 activation, two intracellular mediators reported to be critical for PMN activities.	Calcium	131-138	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
11331079-7	2001	It is concluded that inhibition of IL-8 chemotaxis could represent a new clinical target for ketoprofen isomers and, in fact, contribute to the anti-inflammatory activity of NSAIDs.	Ketoprofen	93-103	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
11422029-2	2001	OBJECTIVES: To study the effect of dimethylfumarate (DMF) on the production of the chemokines CXCL1, CXCL8, CXCL9, CXCL10 and CXCL11, formerly known as GROalpha, interleukin-8, Mig, IP-10 and IP-9/I-TAC, respectively, in human keratinocytes and peripheral blood mononuclear cells (PBMC).	Dimethyl Fumarate	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	101-106
11422029-2	2001	OBJECTIVES: To study the effect of dimethylfumarate (DMF) on the production of the chemokines CXCL1, CXCL8, CXCL9, CXCL10 and CXCL11, formerly known as GROalpha, interleukin-8, Mig, IP-10 and IP-9/I-TAC, respectively, in human keratinocytes and peripheral blood mononuclear cells (PBMC).	Dimethyl Fumarate	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	162-175
11422029-6	2001	RESULTS: Northern blot analysis on isolated keratinocyte RNA preparations showed a dose-dependent inhibition of CXCL1, CXCL8, CXCL9, CXCL10 and CXCL11 transcription by DMF.	Dimethyl Fumarate	168-171	C-X-C motif chemokine ligand 8	Homo sapiens	119-124
11422029-8	2001	In addition, keratinocytes and PBMC showed in the presence of DMF a dose-dependent inhibition of CXCL8, CXCL9 and CXCL10 protein production.	Dimethyl Fumarate	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	97-102
11491146-4	2001	Budesonide (10(-8) M) reduced the amounts of both cytokines (GM-CSF and IL-8) by 40%.	Budesonide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
11491146-0	2001	Effects of formoterol and budesonide on GM-CSF and IL-8 secretion by triggered human bronchial epithelial cells.	Budesonide	26-36	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
11491146-2	2001	Addition of formoterol (&gt; or = 10(-10) M) reduced granulocyte macrophage-colony stimulating factor (GM-CSF) levels, as assessed by enzyme-linked immunosorbent assay, by 40-50% and increased interleukin (IL)-8 levels by approximately 50%.	Formoterol Fumarate	12-22	C-X-C motif chemokine ligand 8	Homo sapiens	193-211
11491146-9	2001	In conclusion, the combination of budesonide and formoterol reduces the secretion of granulocyte macrophage-colony stimulating factor to basal levels and counteracts the capacity of formoterol alone to induce interleukin-8 production, modulations which may facilitate improved asthma control.	Budesonide	34-44	C-X-C motif chemokine ligand 8	Homo sapiens	209-222
11491146-9	2001	In conclusion, the combination of budesonide and formoterol reduces the secretion of granulocyte macrophage-colony stimulating factor to basal levels and counteracts the capacity of formoterol alone to induce interleukin-8 production, modulations which may facilitate improved asthma control.	Formoterol Fumarate	49-59	C-X-C motif chemokine ligand 8	Homo sapiens	209-222
11491146-9	2001	In conclusion, the combination of budesonide and formoterol reduces the secretion of granulocyte macrophage-colony stimulating factor to basal levels and counteracts the capacity of formoterol alone to induce interleukin-8 production, modulations which may facilitate improved asthma control.	Formoterol Fumarate	182-192	C-X-C motif chemokine ligand 8	Homo sapiens	209-222
11403209-3	2001	We observed that exposure of human aortic smooth muscle cells to pathophysiologically relevant concentrations of homocysteine results in concentration-dependent increases in cytokine-induced MCP-1 and IL-8 secretion.	Homocysteine	113-125	C-X-C motif chemokine ligand 8	Homo sapiens	201-205
11403209-4	2001	RNase protection assays revealed that both MCP-1 and IL-8 mRNA concentrations are increased in homocysteine-treated smooth muscle cells when compared to cells activated with cytokines alone.	Homocysteine	95-107	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
11403209-6	2001	Cumulatively, these data suggest that homocysteine may increase monocyte recruitment into developing atherosclerotic lesions by upregulating MCP-1 and IL-8 expression in vascular smooth muscle cells.	Homocysteine	38-50	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
11404389-0	2001	Priming effects of substance P on calcium changes evoked by interleukin-8 in human neutrophils.	Calcium	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	60-73
11381075-7	2001	Combined inhibition of MEK by U0126, p38 by SB202190, and Janus kinase (jak) by AG490 revealed that GHSA stimulation of IL-8 production was predominately mediated by MEK and to a lesser extent by p38 pathways, whereas activation of MEK, p38, and jak was required for maximal MCP-1 induction.	ghsa	100-104	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
11381075-8	2001	Moreover, GHSA-stimulated IL-8 secretion was more sensitive to U0126 (50% inhibitory concentration [IC(50)] = 0.5 microM) than MCP-1 (IC(50) = 10 microM).	ghsa	10-14	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
11381075-8	2001	Moreover, GHSA-stimulated IL-8 secretion was more sensitive to U0126 (50% inhibitory concentration [IC(50)] = 0.5 microM) than MCP-1 (IC(50) = 10 microM).	U 0126	63-68	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
11381075-9	2001	CONCLUSIONS: GHSA stimulates hRPE IL-8 and MCP-1 production through divergent and overlapping, but not identical, intracellular signaling cascades.	ghsa	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
11378323-7	2001	We found that 0.5 M NaCl treatment increased mRNA levels of proinflammatory cytokines such as IL-1alpha, IL-6 and IL-8 as well as ICAM-1 in NHEK and IL-1alpha, IL-1beta and IL-6 mRNA levels in NHDF.	Sodium Chloride	20-24	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
11389120-0	2001	The effect of azithromycin and clarithromycin on ex vivo interleukin-8 (IL-8) release from whole blood and IL-8 production by human alveolar macrophages.	Clarithromycin	31-45	C-X-C motif chemokine ligand 8	Homo sapiens	57-70
11389120-1	2001	We investigated the effects of azithromycin and clarithromycin, two antibiotics that possess a broad spectrum of antimicrobial activity (including antimycobacterial activity), on interleukin-8 (IL-8) release from human whole blood leucocytes and lung macrophages.	Azithromycin	31-43	C-X-C motif chemokine ligand 8	Homo sapiens	179-192
11389120-1	2001	We investigated the effects of azithromycin and clarithromycin, two antibiotics that possess a broad spectrum of antimicrobial activity (including antimycobacterial activity), on interleukin-8 (IL-8) release from human whole blood leucocytes and lung macrophages.	Azithromycin	31-43	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
11389120-1	2001	We investigated the effects of azithromycin and clarithromycin, two antibiotics that possess a broad spectrum of antimicrobial activity (including antimycobacterial activity), on interleukin-8 (IL-8) release from human whole blood leucocytes and lung macrophages.	Clarithromycin	48-62	C-X-C motif chemokine ligand 8	Homo sapiens	179-192
11389120-1	2001	We investigated the effects of azithromycin and clarithromycin, two antibiotics that possess a broad spectrum of antimicrobial activity (including antimycobacterial activity), on interleukin-8 (IL-8) release from human whole blood leucocytes and lung macrophages.	Clarithromycin	48-62	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
11389120-3	2001	Incubation of alveolar macrophages with different concentrations of azithromycin or clarithromycin modified IL-8 production: it increased at a drug concentration of 4 mg/L and decreased at concentration of 400 mg/L.	Azithromycin	68-80	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
11389120-3	2001	Incubation of alveolar macrophages with different concentrations of azithromycin or clarithromycin modified IL-8 production: it increased at a drug concentration of 4 mg/L and decreased at concentration of 400 mg/L.	Clarithromycin	84-98	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
11389120-4	2001	Our findings suggest that azithromycin and clarithromycin may alter IL-8 production, thus enhancing the clinical effectiveness of these antibiotics.	Azithromycin	26-38	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
11389120-4	2001	Our findings suggest that azithromycin and clarithromycin may alter IL-8 production, thus enhancing the clinical effectiveness of these antibiotics.	Clarithromycin	43-57	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
11440632-7	2001	The antioxidant pyrrolidine dithiocarbamate (PDTC) restored the redox equilibrium by mechanisms that inhibit binding of NF-kappaB to its cognate site on the IL-8 promoter.	pyrrolidine dithiocarbamic acid	16-43	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
11440632-7	2001	The antioxidant pyrrolidine dithiocarbamate (PDTC) restored the redox equilibrium by mechanisms that inhibit binding of NF-kappaB to its cognate site on the IL-8 promoter.	pyrrolidine dithiocarbamic acid	45-49	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
11386618-5	2001	The non-selective NOS inhibitor N-nitro-L-arginine methyl ester (L-NAME) did not affect intracellular ROS levels, but it caused a moderate selective inhibition of IL-8 production.	n-nitro-l-arginine methyl ester	32-63	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
11453524-6	2001	Serum levels of IL-6, sIL-6R and IL-8 were markedly elevated in patients with GD before treatment with methimazole (p&lt;0.0001 for IL-6, p&lt;0.006 for sIL-6R, p&lt;0.004 for IL-8) and after 8 weeks of therapy (p&lt;0.011 for IL-6, p&lt;0.04 for IL-8).	Methimazole	103-114	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
11386618-5	2001	The non-selective NOS inhibitor N-nitro-L-arginine methyl ester (L-NAME) did not affect intracellular ROS levels, but it caused a moderate selective inhibition of IL-8 production.	NG-Nitroarginine Methyl Ester	65-71	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
11325811-9	2001	The IL-17-induced release of IL-6 and IL-8 was concentration-dependently inhibited by SB202190 and by PD98059 in bronchial epithelial cells without affecting cell proliferation or survival.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	102-109	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
12585121-0	2001	[Inhibitory effects of isorhapotigenin on IL-8 production and mRNA expression induced with TNF alpha in normal human synovial cells].	isorhapotigenin	23-38	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
12585121-1	2001	AIM: To study the effects of isorhapotigenin (Iso) on interleukin-8 (IL-8) production and mRNA expression in normal human synovial cells (HSC) induced with TNF alpha.	isorhapotigenin	29-44	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
12585121-1	2001	AIM: To study the effects of isorhapotigenin (Iso) on interleukin-8 (IL-8) production and mRNA expression in normal human synovial cells (HSC) induced with TNF alpha.	isorhapotigenin	29-44	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
11342615-7	2001	In addition, histamine induces a potent production of IL-6, IL-8, monocyte chemoattractant protein 1, and macrophage-inflammatory protein 1alpha by immature DC and also up-regulates IL-1beta, RANTES, and macrophage-inflammatory protein 1beta but not TNF-alpha and IL-12 mRNA expression.	Histamine	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
11422128-8	2001	RESULTS: IL-10 inhibited the release of TNF-alpha and of IL-8, but not of IL-5, by activated CBMC.	cbmc	93-97	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
11359392-8	2001	HgCl2 also stimulated the release of low levels of tumour necrosis factor-alpha and interleukin-8 (but not RANTES), and inhibited the release of interleukin-1alpha by oral keratinocytes.	Mercuric Chloride	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
11358991-0	2001	Peroxynitrite mediates cytokine-induced IL-8 gene expression and production by human leukocytes.	Peroxynitrous Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
11410418-6	2001	RESULTS: Throughout storage, refrigerated PCs, both ThromboSol-treated and untreated units, displayed a slightly lower level of IL-6 and significantly lower concentration of IL-8 than conventionally stored PCs.	thrombosol	52-62	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
11437208-2	2001	The objective of the present study was to investigate the fluoride and alkali metal ion release from a relatively simple GIC formulation with fluoride- and alkali metal-free glass and activated with a NaF or KF solution.	Fluorides	58-66	C-X-C motif chemokine ligand 8	Homo sapiens	201-204
11358991-5	2001	The addition of ONOO(-) (0.2-80 microM) to whole blood increased nuclear accumulation of AP-1 and NF-kappaB in PMN and mononuclear leukocytes and augmented IL-8 mRNA expression and IL-8 production in a concentration-dependent fashion.	onoo(-)	16-23	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
11358991-5	2001	The addition of ONOO(-) (0.2-80 microM) to whole blood increased nuclear accumulation of AP-1 and NF-kappaB in PMN and mononuclear leukocytes and augmented IL-8 mRNA expression and IL-8 production in a concentration-dependent fashion.	onoo(-)	16-23	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
11358991-6	2001	Pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB activation, attenuated approximately 70% of IL-8 release evoked by IL-1beta, TNF-alpha, or ONOO(-).	pyrrolidine dithiocarbamic acid	0-27	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
11358991-6	2001	Pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB activation, attenuated approximately 70% of IL-8 release evoked by IL-1beta, TNF-alpha, or ONOO(-).	onoo	146-150	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
11358991-7	2001	These results indicate that ONOO(-) formation may underlie the action of cytokines towards IL-8 gene expression in human leukocytes.	onoo	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
11330965-0	2001	Lysophospholipids increase interleukin-8 expression in ovarian cancer cells.	Lysophospholipids	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
11330965-5	2001	Northern blot analysis was used to confirm and examine IL-8 mRNA regulation by lysolipids.	lysolipids	79-89	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
11358991-1	2001	Recent studies indicate that nitric oxide (NO) or related compounds may regulate the production of interleukin (IL)-8, a potent proinflammatory chemokine.	Nitric Oxide	29-41	C-X-C motif chemokine ligand 8	Homo sapiens	99-117
11358991-2	2001	Here we report that peroxynitrite (ONOO(-)) formed by a reaction of NO with superoxide mediates IL-8 gene expression and IL-8 production in IL-1beta- and TNF-alpha-stimulated human leukocytes in whole blood.	Peroxynitrous Acid	20-33	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
11358991-2	2001	Here we report that peroxynitrite (ONOO(-)) formed by a reaction of NO with superoxide mediates IL-8 gene expression and IL-8 production in IL-1beta- and TNF-alpha-stimulated human leukocytes in whole blood.	Peroxynitrous Acid	20-33	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
11358991-2	2001	Here we report that peroxynitrite (ONOO(-)) formed by a reaction of NO with superoxide mediates IL-8 gene expression and IL-8 production in IL-1beta- and TNF-alpha-stimulated human leukocytes in whole blood.	onoo	35-39	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
11358991-2	2001	Here we report that peroxynitrite (ONOO(-)) formed by a reaction of NO with superoxide mediates IL-8 gene expression and IL-8 production in IL-1beta- and TNF-alpha-stimulated human leukocytes in whole blood.	onoo	35-39	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
11358991-2	2001	Here we report that peroxynitrite (ONOO(-)) formed by a reaction of NO with superoxide mediates IL-8 gene expression and IL-8 production in IL-1beta- and TNF-alpha-stimulated human leukocytes in whole blood.	Superoxides	76-86	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
11358991-2	2001	Here we report that peroxynitrite (ONOO(-)) formed by a reaction of NO with superoxide mediates IL-8 gene expression and IL-8 production in IL-1beta- and TNF-alpha-stimulated human leukocytes in whole blood.	Superoxides	76-86	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
11358991-3	2001	The NO synthase inhibitors aminoguanidine and N(G)-nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear (PMN) and mononuclear leukocytes and inhibited IL-8 mRNA expression and IL-8 release by approximately 90% in response to IL-1beta and TNF-alpha.	pimagedine	27-41	C-X-C motif chemokine ligand 8	Homo sapiens	244-248
11358991-3	2001	The NO synthase inhibitors aminoguanidine and N(G)-nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear (PMN) and mononuclear leukocytes and inhibited IL-8 mRNA expression and IL-8 release by approximately 90% in response to IL-1beta and TNF-alpha.	pimagedine	27-41	C-X-C motif chemokine ligand 8	Homo sapiens	269-273
11358991-3	2001	The NO synthase inhibitors aminoguanidine and N(G)-nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear (PMN) and mononuclear leukocytes and inhibited IL-8 mRNA expression and IL-8 release by approximately 90% in response to IL-1beta and TNF-alpha.	NG-Nitroarginine Methyl Ester	46-80	C-X-C motif chemokine ligand 8	Homo sapiens	244-248
11358991-3	2001	The NO synthase inhibitors aminoguanidine and N(G)-nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear (PMN) and mononuclear leukocytes and inhibited IL-8 mRNA expression and IL-8 release by approximately 90% in response to IL-1beta and TNF-alpha.	NG-Nitroarginine Methyl Ester	46-80	C-X-C motif chemokine ligand 8	Homo sapiens	269-273
11336536-4	2001	The incubation of HCAEC with histamine resulted in low level induction of IL-6 and IL-8 production, which was dose-dependent and attained a plateau at a concentration of 10 microM.	Histamine	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
11336536-0	2001	Histamine-induced production of interleukin-6 and interleukin-8 by human coronary artery endothelial cells is enhanced by endotoxin and tumor necrosis factor-alpha.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	50-63
11336536-7	2001	In the presence of all stimulatory concentrations of LPS and TNF-alpha tested, histamine was shown to further enhance IL-6 and IL-8 production.	Histamine	79-88	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
11336536-10	2001	Since both LPS and TNF-alpha potentiated histamine-induced cytokine production, it is possible that these activators stimulate H-1 receptor expression and/or augment the signal transduction pathways leading to the expression of IL-6 and IL-8.	Histamine	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	237-241
11346209-0	2001	Hydrophilic and hydrophobic bile acids exhibit different cytotoxicities through cytolysis, interleukin-8 synthesis and apoptosis in the intestinal epithelial cell lines.	Bile Acids and Salts	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
11392584-0	2001	Effect of budesonide and nedocromil sodium on IL-6 and IL-8 release from human nasal mucosa and polyp epithelial cells.	Nedocromil	25-42	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
11392584-1	2001	We investigated the effect of budesonide and nedocromil sodium on the secretion of IL-6 and IL-8 by cultured epithelial cells from healthy nasal mucosa and nasal polyps.	Nedocromil	45-62	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
11392584-3	2001	Budesonide inhibited FCS-induced IL-6 and IL-8 release in a dose-dependent manner.	Budesonide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
11392584-5	2001	The IC25 of budesonide on IL-8 release was higher in nasal mucosa than in nasal polyps (145 pM vs. 4 pM).	Budesonide	12-22	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
11392584-6	2001	Nedocromil sodium caused a dose-related inhibitory effect on IL-8 release from nasal mucosa (IC25, 207 nM), while it only had a significant effect in nasal polyps at 10(-5) M. Nedocromil sodium had no effect on IL-6 release.	Nedocromil	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
11346209-7	2001	IL-8 synthesis induced by the bile acids was measured using an ELISA assay.	Bile Acids and Salts	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
11392584-8	2001	Budesonide and nedocromil sodium may exert their anti-inflammatory action in the respiratory mucosa by modulating the secretion of IL-6 and IL-8.	Budesonide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
11392584-8	2001	Budesonide and nedocromil sodium may exert their anti-inflammatory action in the respiratory mucosa by modulating the secretion of IL-6 and IL-8.	Nedocromil	15-32	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
11294978-4	2001	Sodium fluoride (NaF) induced apoptosis in both cell types but at different concentrations, with the primary cells being more sensitive to NAF: Proliferation of the type 2 cells and A549 cells was inhibited in the presence of NAF: NaF induced a prolonged activation of MAP kinase ERK.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
11346209-8	2001	RESULTS: The bile acids induced cytotoxic effects, LDH release, IL-8 synthesis and apoptosis, depending on their hydrophobic properties.	Bile Acids and Salts	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
11294978-4	2001	Sodium fluoride (NaF) induced apoptosis in both cell types but at different concentrations, with the primary cells being more sensitive to NAF: Proliferation of the type 2 cells and A549 cells was inhibited in the presence of NAF: NaF induced a prolonged activation of MAP kinase ERK.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	139-142
11294978-4	2001	Sodium fluoride (NaF) induced apoptosis in both cell types but at different concentrations, with the primary cells being more sensitive to NAF: Proliferation of the type 2 cells and A549 cells was inhibited in the presence of NAF: NaF induced a prolonged activation of MAP kinase ERK.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	226-229
11294978-4	2001	Sodium fluoride (NaF) induced apoptosis in both cell types but at different concentrations, with the primary cells being more sensitive to NAF: Proliferation of the type 2 cells and A549 cells was inhibited in the presence of NAF: NaF induced a prolonged activation of MAP kinase ERK.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	231-234
11392584-9	2001	The different effect of budesonide and nedocromil sodium on IL-6 and IL-8 release may be explained by differences in the mechanisms which regulate the upregulation of these cytokines in inflammatory responses.	Budesonide	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
11392584-9	2001	The different effect of budesonide and nedocromil sodium on IL-6 and IL-8 release may be explained by differences in the mechanisms which regulate the upregulation of these cytokines in inflammatory responses.	Nedocromil	39-56	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
11316662-4	2001	However, BAL macrophages from NA exhibited less suppression of IL-8 and TNF-alpha production by DEX at 4:00 A.M. as compared with 4:00 P.M. (p = 0.0001), whereas in the NNA group DEX suppressed IL-8 and TNF-alpha production equally at both time points.	Dexamethasone	96-99	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
11306435-0	2001	Benzene-extracted components are important for the major activity of diesel exhaust particles: effect on interleukin-8 gene expression in human bronchial epithelial cells.	Benzene	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	105-118
11306435-5	2001	Benzene-extracted components showed effects mimicking DEPs on IL-8 gene expression, release of several cytokines (IL-8; granulocyte macrophage colony-stimulating factor; and regulated on activation, normal T cells expressed and secreted) and nuclear factor (NF)-kappa B activation.	Benzene	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
11306435-5	2001	Benzene-extracted components showed effects mimicking DEPs on IL-8 gene expression, release of several cytokines (IL-8; granulocyte macrophage colony-stimulating factor; and regulated on activation, normal T cells expressed and secreted) and nuclear factor (NF)-kappa B activation.	Benzene	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
11298490-8	2001	For example strong calcium responses were seen in neutrophils following stimulation with the CXCR1 and CXCR2 ligands, interleukin (IL-)8, GCP-2 and Gro-beta.	Calcium	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	118-136
11290562-9	2001	Pretreatment of HPFBs with actinomycin D or puromycin dose-dependently reduced cytokine-stimulated IL-8 and MCP-1 secretion, which suggested de novo chemokine synthesis.	hpfbs	16-21	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
11290562-9	2001	Pretreatment of HPFBs with actinomycin D or puromycin dose-dependently reduced cytokine-stimulated IL-8 and MCP-1 secretion, which suggested de novo chemokine synthesis.	Dactinomycin	27-40	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
11290562-9	2001	Pretreatment of HPFBs with actinomycin D or puromycin dose-dependently reduced cytokine-stimulated IL-8 and MCP-1 secretion, which suggested de novo chemokine synthesis.	Puromycin	44-53	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
11306458-3	2001	The results also show short-term exposure of MCF-7 cells to either Adriamycin or FUdR rapidly increases, in a dose-dependent manner, the release of the angiogenic cytokine, interleukin-8(IL-8), which is released at consistently higher levels in metastatic cell lines.	Doxorubicin	67-77	C-X-C motif chemokine ligand 8	Homo sapiens	173-186
11306458-3	2001	The results also show short-term exposure of MCF-7 cells to either Adriamycin or FUdR rapidly increases, in a dose-dependent manner, the release of the angiogenic cytokine, interleukin-8(IL-8), which is released at consistently higher levels in metastatic cell lines.	Doxorubicin	67-77	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
11306458-5	2001	Survivors of sequential treatment with Adriamycin and FUdR (MCF-7 A/F) release the most IL-8 and express the greatest phenotypic variance from the parental, MCF-7 cells.	Doxorubicin	39-49	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
11309322-13	2001	CONCLUSIONS: Addition of TNF to melphalan during IHP results in significant differences in post-IHP production of IL-6 and IL-8 with associated changes in mean arterial blood pressure and greater regional toxicity, as reflected in higher levels of serum bilirubin.	Melphalan	32-41	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
11296168-11	2001	FENO may be related to neutrophilic inflammation driven by the chemoattractant IL-8.	flubendiamide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
11254557-7	2001	Anti-CD14 monoclonal antibody (MAb) MY4, anti-TLR4 MAb HTA125, and the synthetic lipid A precursor LA-14-PP almost completely inhibited the IL-8-inducing activities of LTA as well as LPS on OCT-treated THP-1 cells, but these treatments increased MDP activity.	la-14-pp	99-107	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
11359455-0	2001	The IL-8 release from cultured human keratinocytes, mediated by antibodies to bullous pemphigoid autoantigen 180, is inhibited by dapsone.	Dapsone	130-137	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
11359455-7	2001	We demonstrate that dapsone, but not nicotinamide, in its pharmacological range, inhibits the IL-8, but not the IL-6 release from NHEK, induced by anti-BP180 IgG, in a dose-dependent fashion as detected by ELISA.	Dapsone	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
11359455-8	2001	IL-8 mRNA levels, as determined by RT-PCR, were the same in cells treated with BP IgG alone compared to cells treated with BP IgG plus dapsone.	Dapsone	135-142	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
11359455-9	2001	This observation suggests that dapsone inhibits the BP IgG-induced IL-8 release from cultured NHEK by mechanisms at the post-transcriptional level.	Dapsone	31-38	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
11399518-10	2001	Production of inflammatory cytokines (IL-1 beta, TNF-alpha, IL-6, IL-8) was significantly increased, mostly by the Sambucol Black Elderberry Extract (2-45 fold), as compared to LPS, a known monocyte activator (3.6-10.7 fold).	sambucol black elderberry	115-140	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
11321363-1	2001	Interleukin-8 (IL-8), C5a and N-formyl-methionyl-leucyl-phenylalanine (fMLP) are chemotactic peptides with predominant effects on leukocytes during inflammation.	N-Formylmethionine Leucyl-Phenylalanine	71-75	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
11392610-0	2001	Calcium-dependent interleukin-8 gene expression in T84 human colonic epithelial cells.	Calcium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
11392610-7	2001	RESULTS: A23187 and thapsigargin caused a dose- and time-dependent accumulation of IL-8 mRNA and protein production which was dependent on the release of Ca2+ from intracellular stores.	Calcimycin	9-15	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
11328384-1	2001	Although adenosine/uridine (AU)-rich sequences in the 3"-untranslated region (UTR) of the interleukin-8 (IL-8) gene have been suggested to contribute to its post-transcriptional regulation, the molecular basis whereby this occurs still needs to be understood.	Adenosine	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	90-103
11295678-2	2001	In vitro studies have shown that desloratadine inhibits the release or generation of multiple inflammatory mediators, including IL-4, IL-6, IL-8, IL-13, PGD(2), leukotriene C(4), tryptase, histamine, and the TNF-alpha-induced chemokine RANTES.	desloratadine	33-46	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
11328384-1	2001	Although adenosine/uridine (AU)-rich sequences in the 3"-untranslated region (UTR) of the interleukin-8 (IL-8) gene have been suggested to contribute to its post-transcriptional regulation, the molecular basis whereby this occurs still needs to be understood.	Adenosine	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
11328384-1	2001	Although adenosine/uridine (AU)-rich sequences in the 3"-untranslated region (UTR) of the interleukin-8 (IL-8) gene have been suggested to contribute to its post-transcriptional regulation, the molecular basis whereby this occurs still needs to be understood.	Uridine	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	90-103
11328384-1	2001	Although adenosine/uridine (AU)-rich sequences in the 3"-untranslated region (UTR) of the interleukin-8 (IL-8) gene have been suggested to contribute to its post-transcriptional regulation, the molecular basis whereby this occurs still needs to be understood.	Uridine	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
11328384-1	2001	Although adenosine/uridine (AU)-rich sequences in the 3"-untranslated region (UTR) of the interleukin-8 (IL-8) gene have been suggested to contribute to its post-transcriptional regulation, the molecular basis whereby this occurs still needs to be understood.	Gold	28-30	C-X-C motif chemokine ligand 8	Homo sapiens	90-103
11328384-1	2001	Although adenosine/uridine (AU)-rich sequences in the 3"-untranslated region (UTR) of the interleukin-8 (IL-8) gene have been suggested to contribute to its post-transcriptional regulation, the molecular basis whereby this occurs still needs to be understood.	Gold	28-30	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
11392610-7	2001	RESULTS: A23187 and thapsigargin caused a dose- and time-dependent accumulation of IL-8 mRNA and protein production which was dependent on the release of Ca2+ from intracellular stores.	Thapsigargin	20-32	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
11392610-8	2001	FK506, a specific inhibitor of calcineurin, inhibited A23187- and thapsigargin-induced IL-8 mRNA expression in a dose dependent manner.	Tacrolimus	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
11392610-8	2001	FK506, a specific inhibitor of calcineurin, inhibited A23187- and thapsigargin-induced IL-8 mRNA expression in a dose dependent manner.	Calcimycin	54-60	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
11392610-8	2001	FK506, a specific inhibitor of calcineurin, inhibited A23187- and thapsigargin-induced IL-8 mRNA expression in a dose dependent manner.	Thapsigargin	66-78	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
11392610-9	2001	Reporter gene studies and actinomycin D chase experiments showed that A23187 and thapsigargin enhanced IL-8 gene transcription and stabilized IL-8 mRNA transcripts, respectively.	Calcimycin	70-76	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
11392610-9	2001	Reporter gene studies and actinomycin D chase experiments showed that A23187 and thapsigargin enhanced IL-8 gene transcription and stabilized IL-8 mRNA transcripts, respectively.	Calcimycin	70-76	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
11392610-9	2001	Reporter gene studies and actinomycin D chase experiments showed that A23187 and thapsigargin enhanced IL-8 gene transcription and stabilized IL-8 mRNA transcripts, respectively.	Thapsigargin	81-93	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
11392610-9	2001	Reporter gene studies and actinomycin D chase experiments showed that A23187 and thapsigargin enhanced IL-8 gene transcription and stabilized IL-8 mRNA transcripts, respectively.	Thapsigargin	81-93	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
11254300-2	2001	The kinetic effects of added salts (NaF, NaCl, NaBr, and NaNO(3)) on the reaction rate in SB3-14 aqueous micellar solutions have also been studied.	3-(N,N-Dimethylmyristylammonio)propanesulfonate	90-96	C-X-C motif chemokine ligand 8	Homo sapiens	36-39
11240858-5	2001	The IL-8 production activity of polysaccharide from P. gingivalis was higher than that of other cell-surface components.	Polysaccharides	32-46	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
11347983-8	2001	IL-8 and IL-10 levels were significantly higher in the CPB than in the off-pump patients after reperfusion (p=0.006 and 0.001 respectively).	cpb	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
11441488-0	2001	Effects of polysiloxane coating of NaF on the release profile of fluoride ion from Bis-GMA/TEGDMA resin containing NaF.	Fluorides	65-73	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
11280799-10	2001	Additional transfection studies with progressively COOH-terminally truncated PTHrP1-87 defined a 23-amino acid sequence, PTHrP65-87, required for PTHrP1-87 to robustly stimulate IL-8 in prostate cancer cells.	Carbonic Acid	51-55	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
11441488-3	2001	Bis-GMA/TEGDMA resin containing NaF powder treated with AMMS released lower concentrations of fluoride for longer periods when compared with that containing untreated NaF.	Fluorides	94-102	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
11260138-8	2001	Full interleukin 8 induction required hexa-acylated lipid A and was decreased by between 50% and 70% in the presence of O-antigen.	Lipid A	52-59	C-X-C motif chemokine ligand 8	Homo sapiens	5-18
11441488-4	2001	However, AMMS treatment of NaF was less effective for the regulation of fluoride released from the resin than gamma-methacryloxypropyltrimethoxysilane (gamma-MPTS) treatment, despite its higher hydrophobic polysiloxane layer formation.	Fluorides	72-80	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
11441488-0	2001	Effects of polysiloxane coating of NaF on the release profile of fluoride ion from Bis-GMA/TEGDMA resin containing NaF.	Fluorides	65-73	C-X-C motif chemokine ligand 8	Homo sapiens	115-118
11441488-0	2001	Effects of polysiloxane coating of NaF on the release profile of fluoride ion from Bis-GMA/TEGDMA resin containing NaF.	Bisphenol A-Glycidyl Methacrylate	83-90	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
11441488-6	2001	The present findings suggested, therefore, that alkoxysilane should be chosen based not only on hydrophobicity but also the density of polysiloxane to effectively regulate fluoride release from the restorative resin containing NaF.	alkoxysilane	48-60	C-X-C motif chemokine ligand 8	Homo sapiens	227-230
11441488-0	2001	Effects of polysiloxane coating of NaF on the release profile of fluoride ion from Bis-GMA/TEGDMA resin containing NaF.	Bisphenol A-Glycidyl Methacrylate	83-90	C-X-C motif chemokine ligand 8	Homo sapiens	115-118
11441488-6	2001	The present findings suggested, therefore, that alkoxysilane should be chosen based not only on hydrophobicity but also the density of polysiloxane to effectively regulate fluoride release from the restorative resin containing NaF.	Fluorides	172-180	C-X-C motif chemokine ligand 8	Homo sapiens	227-230
11441488-1	2001	The aim of this study was to regulate fluoride release from restorative resin containing NaF using N-(beta-aminoethyl)-gamma-aminopropylmethyldimethoxysilane (AMMS) and evaluate factors that regulate fluoride release from the resin.	Fluorides	38-46	C-X-C motif chemokine ligand 8	Homo sapiens	89-92
11441488-1	2001	The aim of this study was to regulate fluoride release from restorative resin containing NaF using N-(beta-aminoethyl)-gamma-aminopropylmethyldimethoxysilane (AMMS) and evaluate factors that regulate fluoride release from the resin.	n-(beta-aminoethyl)-gamma-aminopropylmethyldimethoxysilane	99-157	C-X-C motif chemokine ligand 8	Homo sapiens	89-92
11441488-2	2001	ESCA analysis, FT-IR measurements along with SEM observations demonstrated that a polysiloxane layer was formed on the surface of NaF treated with AMMS.	Siloxanes	82-94	C-X-C motif chemokine ligand 8	Homo sapiens	130-133
11441488-3	2001	Bis-GMA/TEGDMA resin containing NaF powder treated with AMMS released lower concentrations of fluoride for longer periods when compared with that containing untreated NaF.	Bisphenol A-Glycidyl Methacrylate	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
11441488-3	2001	Bis-GMA/TEGDMA resin containing NaF powder treated with AMMS released lower concentrations of fluoride for longer periods when compared with that containing untreated NaF.	Bisphenol A-Glycidyl Methacrylate	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	167-170
11441488-3	2001	Bis-GMA/TEGDMA resin containing NaF powder treated with AMMS released lower concentrations of fluoride for longer periods when compared with that containing untreated NaF.	triethylene glycol dimethacrylate	8-14	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
11231943-5	2001	Butyrate maximally stimulated cell cycle arrest, apoptosis, alkaline phosphatase activity, transepithelial resistance, cell migration, urokinase receptor expression, and interleukin 8 secretion in undifferentiated Caco-2 cells, whereas differentiated Caco-2 cells were essentially resistant to these effects.	Butyrates	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	170-183
11222496-9	2001	By blocking activation of ERK1/2 with a MEK-specific inhibitor, PD98059, CD40-dependent secretion of the pro-inflammatory cytokines, TNF-alpha, IL-6 and IL-8, was demonstrated to be linked to the ERK1/2 pathway.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	64-71	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
11230738-6	2001	Degranulation induced by 100 to 500 micromol/L TCDCA was an active and regulated release because it was completely abolished by a tyrosine kinase inhibitor (genistein), by a microfilament inhibitor (cytochalasin B), and by incubation at 4 degrees C. Furthermore, eosinophils stimulated with 10 to 250 micromol/L TCDCA vigorously produced superoxide and interleukin-8 (IL-8).	Taurochenodeoxycholic Acid	47-52	C-X-C motif chemokine ligand 8	Homo sapiens	353-366
11230738-6	2001	Degranulation induced by 100 to 500 micromol/L TCDCA was an active and regulated release because it was completely abolished by a tyrosine kinase inhibitor (genistein), by a microfilament inhibitor (cytochalasin B), and by incubation at 4 degrees C. Furthermore, eosinophils stimulated with 10 to 250 micromol/L TCDCA vigorously produced superoxide and interleukin-8 (IL-8).	Taurochenodeoxycholic Acid	47-52	C-X-C motif chemokine ligand 8	Homo sapiens	368-372
11230738-6	2001	Degranulation induced by 100 to 500 micromol/L TCDCA was an active and regulated release because it was completely abolished by a tyrosine kinase inhibitor (genistein), by a microfilament inhibitor (cytochalasin B), and by incubation at 4 degrees C. Furthermore, eosinophils stimulated with 10 to 250 micromol/L TCDCA vigorously produced superoxide and interleukin-8 (IL-8).	Genistein	157-166	C-X-C motif chemokine ligand 8	Homo sapiens	353-366
11230738-6	2001	Degranulation induced by 100 to 500 micromol/L TCDCA was an active and regulated release because it was completely abolished by a tyrosine kinase inhibitor (genistein), by a microfilament inhibitor (cytochalasin B), and by incubation at 4 degrees C. Furthermore, eosinophils stimulated with 10 to 250 micromol/L TCDCA vigorously produced superoxide and interleukin-8 (IL-8).	Genistein	157-166	C-X-C motif chemokine ligand 8	Homo sapiens	368-372
11159726-7	2001	The maximum extent of attenuation was RANTES &gt; or = eotaxin &gt; GM-CSF &gt;&gt; IL-8, and was prevented by either propranolol (1 microM), a non-selective beta-adrenoceptor antagonist, or ICI 118511 (IC(50) 15 nM), a selective beta(2)-adrenoceptor antagonist.	Propranolol	118-129	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
11238519-5	2001	Dexamethasone (50 nM) decreased IL-8 production from adipose tissue fragments by 57% (P &lt; 0.01) and from adipocytes by 37% (P &lt; 0.05).	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
11238519-7	2001	Thus, the effect of proinflammatory cytokines and dexamethasone on IL-8 production in adipose tissue seems to be mediated at the transcriptional level.	Dexamethasone	50-63	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
11261782-8	2001	Increased ICAM-3 expression was of functional significance, such that processes stimulated or co-stimulated via ICAM-3 (homotypic aggregation, IL-8 secretion) were clearly enhanced upon RA pretreatment, suggesting that RA may contribute via hitherto unrecognized pathways to immune function and host defense.	Tretinoin	186-188	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
11354255-3	2001	Recent studies have revealed that cells possess two cholesterol-sensors: (a) Receptor-Ck which senses the extracellular cholesterol and initiates signalling pathway responsible for the regulation of genes involved in the cell cycle, cell death, cellular cholesterol homeostasis and cytokines including IL-6; (b) LxR alpha which senses intracellular oxysterols and controls genes involved in cell death, cellular cholesterol homeostasis and cytokine IL-8.	Cholesterol	120-131	C-X-C motif chemokine ligand 8	Homo sapiens	449-453
11354255-4	2001	These cholesterol sensors define the molecular mechanism responsible for cholesterol-depended regulation of cellular synthesis and secretion of cytokines (IL-6, IL-8) within arterial wall.	Cholesterol	6-17	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
11354255-4	2001	These cholesterol sensors define the molecular mechanism responsible for cholesterol-depended regulation of cellular synthesis and secretion of cytokines (IL-6, IL-8) within arterial wall.	Cholesterol	73-84	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
11159540-8	2001	Mechanisms of intracellular signaling differed; the deactivation of IL-8-induced chemotaxis resulted from tyrphostin-sensitive interactions of AT III-signaling with the IL-8 signal transduction pathway, whereas AT III-induced chemotaxis involved protein kinase C and phosphodiesterases.	Tyrphostins	106-116	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
11159540-8	2001	Mechanisms of intracellular signaling differed; the deactivation of IL-8-induced chemotaxis resulted from tyrphostin-sensitive interactions of AT III-signaling with the IL-8 signal transduction pathway, whereas AT III-induced chemotaxis involved protein kinase C and phosphodiesterases.	Tyrphostins	106-116	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
11354255-3	2001	Recent studies have revealed that cells possess two cholesterol-sensors: (a) Receptor-Ck which senses the extracellular cholesterol and initiates signalling pathway responsible for the regulation of genes involved in the cell cycle, cell death, cellular cholesterol homeostasis and cytokines including IL-6; (b) LxR alpha which senses intracellular oxysterols and controls genes involved in cell death, cellular cholesterol homeostasis and cytokine IL-8.	Cholesterol	52-63	C-X-C motif chemokine ligand 8	Homo sapiens	449-453
11354255-3	2001	Recent studies have revealed that cells possess two cholesterol-sensors: (a) Receptor-Ck which senses the extracellular cholesterol and initiates signalling pathway responsible for the regulation of genes involved in the cell cycle, cell death, cellular cholesterol homeostasis and cytokines including IL-6; (b) LxR alpha which senses intracellular oxysterols and controls genes involved in cell death, cellular cholesterol homeostasis and cytokine IL-8.	Cholesterol	120-131	C-X-C motif chemokine ligand 8	Homo sapiens	449-453
11354255-3	2001	Recent studies have revealed that cells possess two cholesterol-sensors: (a) Receptor-Ck which senses the extracellular cholesterol and initiates signalling pathway responsible for the regulation of genes involved in the cell cycle, cell death, cellular cholesterol homeostasis and cytokines including IL-6; (b) LxR alpha which senses intracellular oxysterols and controls genes involved in cell death, cellular cholesterol homeostasis and cytokine IL-8.	Cholesterol	120-131	C-X-C motif chemokine ligand 8	Homo sapiens	449-453
11161457-6	2001	RESULTS: glutamine given in vivo and in vitro significantly decreased IL-6 [1.4 (0.8-8.5) vs 8.9 (1.0-43.9)] and IL-8 production [5.8 (0-51.4) vs. 53.0 (2.5-114.6), pg/mg wet tissue], median (range), both P&lt; or =0.01, in comparison to no glutamine experiments.	Glutamine	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
11159726-14	2001	We conclude in human ASM cells that activation of beta(2)-adrenoceptors and generation of cyclic AMP is negatively-linked to the release, elicited by IL-1 beta or TNF alpha, of eosinophil-activating cytokines such as GM-CSF, RANTES and eotaxin, but not IL-8.	Cyclic AMP	90-100	C-X-C motif chemokine ligand 8	Homo sapiens	253-257
11277180-10	2001	Higher IL-6 and IL-8 levels were directly associated with lower phosphorus levels.	Phosphorus	64-74	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
11234901-7	2001	Basal and tumor necrosis factor-alpha-inducible phosphorylation of ERK1/2 and secretion of IL-8 and VEGF could be specifically inhibited by a MEK inhibitor, U0126.	U 0126	157-162	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
11174195-2	2001	OBJECTIVE: We aimed to investigate the effects of O3 and NO2 on the release of IL-8, GM-CSF, RANTES, and soluble intercellular adhesion molecule 1 (sICAM-1) from human bronchial epithelial cells (HBECs) of nonatopic nonasthmatic subjects (nonasthmatic subjects) and atopic subjects with mild asthma (asthmatic subjects) in vitro.	Ozone	50-52	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
11174195-2	2001	OBJECTIVE: We aimed to investigate the effects of O3 and NO2 on the release of IL-8, GM-CSF, RANTES, and soluble intercellular adhesion molecule 1 (sICAM-1) from human bronchial epithelial cells (HBECs) of nonatopic nonasthmatic subjects (nonasthmatic subjects) and atopic subjects with mild asthma (asthmatic subjects) in vitro.	Nitrogen Dioxide	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
11174195-6	2001	Exposure of HBECs of asthmatic subjects to both 50 to 100 ppb O3 and 200 to 400 ppb NO2 significantly increased the release of IL-8, GM-CSF, RANTES, and sICAM-1 from these cells after 24 hours of incubation.	Nitrogen Dioxide	84-87	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
11174198-3	2001	OBJECTIVE: The objective of this study was to examine whether histamine can alter the expression of the 4 genes encoding H1 receptor, IL-8, TNF-alpha, and ZO-1 tight-junction protein in cultured nasal epithelial cells.	Histamine	62-71	C-X-C motif chemokine ligand 8	Homo sapiens	121-138
11174198-6	2001	RESULTS: Histamine significantly upregulated IL-8 mRNA expression and significantly downregulated ZO-1 mRNA expression.	Histamine	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
11251624-6	2001	On separate occasions, we investigated the effect of PTL11028, a highly potent and selective Der p1 inhibitor, on HDM allergen-induced release of IL-8, following activation of HDM allergen by incubation with cysteine.	PTL 11028	53-61	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
11251624-11	2001	Incubation with HDM allergen led to a significant, dose and time-dependent increase in the release of IL-8, which was further enhanced when the allergen extract was pre-activated with cysteine.	Cysteine	184-192	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
11251624-13	2001	Prepared solutions of various concentrations of IL-8, IL-1beta and sICAM-1 exposed to cigarette smoke demonstrated a dramatic exposure time-dependent decrease in the detectable amount of these mediators, an effect which was abrogated by GSH.	Glutathione	237-240	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
11159885-0	2001	Disaccharides derived from heparin or heparan sulfate regulate IL-8 and IL-1 beta secretion by intestinal epithelial cells.	Disaccharides	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
11159885-0	2001	Disaccharides derived from heparin or heparan sulfate regulate IL-8 and IL-1 beta secretion by intestinal epithelial cells.	Heparin	27-34	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
11159885-0	2001	Disaccharides derived from heparin or heparan sulfate regulate IL-8 and IL-1 beta secretion by intestinal epithelial cells.	Heparitin Sulfate	38-53	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
11289656-8	2001	Dexamethasone also inhibited the release of IL-6, IL-8, and PGE2 induced by IL-1beta in both OA and RA fibroblasts.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
11289656-10	2001	Hymenialdisine inhibited IL-6 production and reduced IL-8 production dependent on synovial cell strains.	hymenialdisine	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
11216967-8	2001	4) Monocyte chemoattractant protein-1 enhanced the generation of O2- in monocytes from unstable angina patients, and the antioxidant glutathione-monoethyl ester suppressed the production of IL-8 and MCP-1 in these cells.	S-ethyl glutathione	133-160	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
11251036-6	2001	The infusion of hydrocortisone was associated with significant reductions in serum IL-6 and IL-8 levels and with earlier resolution of the sepsis-induced organ dysfunction syndrome.	Hydrocortisone	16-30	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
11160671-12	2001	Finally, we demonstrate that the presence of the proteasome inhibitor MG-132 inhibits the induction of NF-kappa B binding, as well as IL-8 expression, supporting the role of NF-kappa B.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	70-76	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
11344824-9	2001	Acetaldehyde markedly increased TNF-alpha and IL-8 expression, stimulated IL-1 beta and IL-8 secretion, increased lipid peroxidation damage and decreased catalase activity, while LPS exposure induced the expression of TNF-alpha, TGF-beta 1, IL-6 and IL-8, the secretion of TGF-beta 1, IL-1 beta, IL-6 and IL-8, and a decrease in catalase activity.	Acetaldehyde	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
11344824-9	2001	Acetaldehyde markedly increased TNF-alpha and IL-8 expression, stimulated IL-1 beta and IL-8 secretion, increased lipid peroxidation damage and decreased catalase activity, while LPS exposure induced the expression of TNF-alpha, TGF-beta 1, IL-6 and IL-8, the secretion of TGF-beta 1, IL-1 beta, IL-6 and IL-8, and a decrease in catalase activity.	Acetaldehyde	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
11344824-9	2001	Acetaldehyde markedly increased TNF-alpha and IL-8 expression, stimulated IL-1 beta and IL-8 secretion, increased lipid peroxidation damage and decreased catalase activity, while LPS exposure induced the expression of TNF-alpha, TGF-beta 1, IL-6 and IL-8, the secretion of TGF-beta 1, IL-1 beta, IL-6 and IL-8, and a decrease in catalase activity.	Acetaldehyde	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
11344824-9	2001	Acetaldehyde markedly increased TNF-alpha and IL-8 expression, stimulated IL-1 beta and IL-8 secretion, increased lipid peroxidation damage and decreased catalase activity, while LPS exposure induced the expression of TNF-alpha, TGF-beta 1, IL-6 and IL-8, the secretion of TGF-beta 1, IL-1 beta, IL-6 and IL-8, and a decrease in catalase activity.	Acetaldehyde	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
11166656-11	2001	In contrast, after ex vivo priming with TNFalpha or IL-8, neutrophils showed a decreased H2O2 production in response to bacterial N-formyl peptides.	Hydrogen Peroxide	89-93	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
11166656-11	2001	In contrast, after ex vivo priming with TNFalpha or IL-8, neutrophils showed a decreased H2O2 production in response to bacterial N-formyl peptides.	n-formyl peptides	130-147	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
11180086-0	2001	Interleukin-8 serum level shift in patients with ovarian carcinoma undergoing paclitaxel-containing chemotherapy.	Paclitaxel	78-88	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
11158523-1	2001	Polymorphonuclear leukocytes (PMN) of the newborn, to a greater extent than those of the adult, have the ability to amplify PMN recruitment to an inflammatory site by their own release of IL-8, and this process is inhibited by dexamethasone.	Dexamethasone	227-240	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
11439889-0	2001	[Calcium dependent effect of clarithromycin on IL-8 production in cultured human epidermal cells].	Calcium	1-8	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
11439889-0	2001	[Calcium dependent effect of clarithromycin on IL-8 production in cultured human epidermal cells].	Clarithromycin	29-43	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
11180086-1	2001	BACKGROUND: Paclitaxel has been described to induce interleukin-8 (IL-8) transcription and secretion in human ovarian carcinoma cells.	Paclitaxel	12-22	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
11180086-1	2001	BACKGROUND: Paclitaxel has been described to induce interleukin-8 (IL-8) transcription and secretion in human ovarian carcinoma cells.	Paclitaxel	12-22	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
11180086-2	2001	The objective of this study was to investigate possible clinical implications of the effect of paclitaxel on IL-8 serum levels in patients suffering from ovarian carcinoma.	Paclitaxel	95-105	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
11180086-12	2001	CONCLUSIONS: The authors found a significant decrease in IL-8 serum levels in patients undergoing a paclitaxel-containing chemotherapy regimen, indicating that IL-8 possibly acts as a useful monitoring marker in patients with ovarian carcinoma.	Paclitaxel	100-110	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
11180086-12	2001	CONCLUSIONS: The authors found a significant decrease in IL-8 serum levels in patients undergoing a paclitaxel-containing chemotherapy regimen, indicating that IL-8 possibly acts as a useful monitoring marker in patients with ovarian carcinoma.	Paclitaxel	100-110	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
11270500-8	2001	Several studies have shown macrolides to inhibit interleukin gene expression for IL-6 and IL-8 and also to inhibit the expression of intercellular adhesion molecule essential for the recruitment of inflammatory cells.	Macrolides	27-37	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
11145710-4	2001	Cytochalasin D significantly inhibited the recycling of both CXCR1 and CXCR2 following IL-8-induced internalization, the inhibition being more pronounced for CXCR2 than for CXCR1.	Cytochalasin D	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
11133489-4	2001	A high dose of ASA blocked IL-1 beta- and TNF-alpha-induced TNF-alpha and IL-8 expression, respectively.	Aspirin	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
11121390-7	2001	Finally, using the specific MAPK inhibitor PD-98059, we demonstrated that MAPK activation is needed for neutrophil chemotaxis toward interleukin-8 and its priming by GM-CSF.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	133-146
11774557-0	2001	Effect of polysaccharide sulfates on the production of interleukin-8 in an ex vivo model.	polysaccharide sulfates	10-33	C-X-C motif chemokine ligand 8	Homo sapiens	55-68
12083969-8	2001	Repair of both defective channels and high IL-8 secretion can also be effected by treatment with the candidate CF drug CPX, which is in clinical trials in CF patients.	1,3-dipropyl-8-cyclopentylxanthine	119-122	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
11133500-0	2001	Mechanism of dexamethasone-mediated interleukin-8 gene suppression in cultured airway epithelial cells.	Dexamethasone	13-26	C-X-C motif chemokine ligand 8	Homo sapiens	36-49
11133500-1	2001	The effects of dexamethasone, a glucocorticoid analog, on interleukin 8 (IL-8) gene expression were studied in cultures of primary human tracheobronchial epithelial cells and an immortalized human bronchial epithelial cell line, HBE1 cells.	Dexamethasone	15-28	C-X-C motif chemokine ligand 8	Homo sapiens	58-71
11133500-1	2001	The effects of dexamethasone, a glucocorticoid analog, on interleukin 8 (IL-8) gene expression were studied in cultures of primary human tracheobronchial epithelial cells and an immortalized human bronchial epithelial cell line, HBE1 cells.	Dexamethasone	15-28	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
11133500-2	2001	Dexamethasone inhibited IL-8 mRNA and protein expression in a concentration- and time-dependent manner.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
11133500-4	2001	Instead, there was a change in IL-8 mRNA stability in dexamethasone-treated cultures.	Dexamethasone	54-67	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
11133500-5	2001	Under actinomycin D treatment, IL-8 mRNA was quite stable in dexamethasone-depleted cultures, while in dexamethasone-pretreated cultures, IL-8 message was rapidly degraded within the first hour, then leveled off.	Dactinomycin	6-19	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
11133500-5	2001	Under actinomycin D treatment, IL-8 mRNA was quite stable in dexamethasone-depleted cultures, while in dexamethasone-pretreated cultures, IL-8 message was rapidly degraded within the first hour, then leveled off.	Dexamethasone	61-74	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
12083969-10	2001	CPX also suppresses the synthesis and secretion of IL-8 from CF epithelial cells, presumably by virtue of its repair of the trafficking defect of mutant CFTR.	1,3-dipropyl-8-cyclopentylxanthine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
11133500-5	2001	Under actinomycin D treatment, IL-8 mRNA was quite stable in dexamethasone-depleted cultures, while in dexamethasone-pretreated cultures, IL-8 message was rapidly degraded within the first hour, then leveled off.	Dexamethasone	103-116	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
11133500-6	2001	When dexamethasone and actinomycin D were added simultaneously to dexamethasone-depleted cultures, IL-8 mRNA remained rather stable.	Dexamethasone	5-18	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
11167428-7	2001	Both agents caused significant decreases in IL-8 levels (propofol: 30%, midazolam: 48%, p &lt; 0.05).	Propofol	57-65	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
12083969-15	2001	For the latter algorithm we modified IL-8 secretion from CF cells by treatment with wild-type CFTR, with CPX, or by exposure to bacteria.	1,3-dipropyl-8-cyclopentylxanthine	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
11167428-7	2001	Both agents caused significant decreases in IL-8 levels (propofol: 30%, midazolam: 48%, p &lt; 0.05).	Midazolam	72-81	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
11133500-6	2001	When dexamethasone and actinomycin D were added simultaneously to dexamethasone-depleted cultures, IL-8 mRNA remained rather stable.	Dactinomycin	23-36	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
11133500-6	2001	When dexamethasone and actinomycin D were added simultaneously to dexamethasone-depleted cultures, IL-8 mRNA remained rather stable.	Dexamethasone	66-79	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
11167428-9	2001	In conclusion, during 48 h of continuous infusion, propofol stimulated, while midazolam suppressed, the production of the pro-inflammatory cytokines IL-1beta, IL-6 and TNF-alpha, and both caused suppression of IL-8 production.	Propofol	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
11673649-3	2001	High glucose concentrations increased IL-8 mRNA levels in a MAPK-p38-dependent manner, which was suppressed by shear stress.	Glucose	5-12	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
11133500-8	2001	These results suggest that a posttranscriptional mechanism, which requires dexamethasone-dependent new protein synthesis, is involved in the regulation of IL-8 mRNA by dexamethasone in airway epithelial cells.	Dexamethasone	75-88	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
11133500-8	2001	These results suggest that a posttranscriptional mechanism, which requires dexamethasone-dependent new protein synthesis, is involved in the regulation of IL-8 mRNA by dexamethasone in airway epithelial cells.	Dexamethasone	168-181	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
11673649-4	2001	Measurement of IL-8 protein in HUVEC culture media by ELISA demonstrated that IL-8 secretion was also increased by high glucose and suppressed by shear stress.	Glucose	120-127	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
11673649-4	2001	Measurement of IL-8 protein in HUVEC culture media by ELISA demonstrated that IL-8 secretion was also increased by high glucose and suppressed by shear stress.	Glucose	120-127	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
11156247-7	2000	Treatment with paclitaxel and C225 down-regulated the expression of basic fibroblast growth factor, vascular endothelial cell growth factor, interleukin-8, and matrix metalloproteinase type 9 and inhibited tumor-induced neovascularity compared with untreated controls (P &lt; 0.005).	Paclitaxel	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	141-154
11455057-5	2001	The animals were divided in 2 groups of 10 each: (1) intravenous injection of sodium fluorescein (14 mg/kg of body weight)--Group NaF, (2) controls (injection of NaCl 0.9%)--Group CTRL.	Fluorescein	78-96	C-X-C motif chemokine ligand 8	Homo sapiens	130-133
11235021-2	2001	Since interleukin-8 and interleukin-10 are involved in the pathogenesis of psoriasis, the aim of our study was to investigate the effect of dithranol on interleukin-8, interleukin-10 mRNA production and interleukin-10 receptor expression of the HaCaT keratinocyte cell line which is commonly used in experiments examining the effects of therapeutic drugs on keratinocytes.	Anthralin	140-149	C-X-C motif chemokine ligand 8	Homo sapiens	153-166
12094614-0	2001	Green tea catechins and vitamin E inhibit angiogenesis of human microvascular endothelial cells through suppression of IL-8 production.	Catechin	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
12094614-0	2001	Green tea catechins and vitamin E inhibit angiogenesis of human microvascular endothelial cells through suppression of IL-8 production.	Vitamin E	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
12094614-4	2001	In this model, the production of interleukin (IL)-8 by human microvascular endothelial cells at a low level of H2O2 was required for angiogenesis, as assessed by tube formation in three-dimensional gel in culture.	Hydrogen Peroxide	111-115	C-X-C motif chemokine ligand 8	Homo sapiens	33-51
12094614-5	2001	Vitamin E (d-alpha-tocopherol, 40 microM) in the culture media significantly reduced IL-8 production and angiogenesis.	Vitamin E	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
11565117-3	2001	The author considers, that interleukin-8 is connected with high concentration of oxygen active forms in neutrophils in the patients with this stage of disease.	Oxygen	81-87	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
11137126-7	2000	Daily intramuscular treatment of GB piglets with 1mg/kg of FK506 from birth for 4 weeks resulted in lowered (P&lt;0.05) in vitro secretion of interferon-gamma and interleukin-8.	Tacrolimus	59-64	C-X-C motif chemokine ligand 8	Homo sapiens	163-176
11137126-9	2000	The depletions of mononuclear cells and low levels of interferon-gamma and interleukin-8 in piglets treated with FK506 were accompanied by lower proportion of CD3+, CD2+CD4+ and CD2+CD8+ T-cell phenotypes in peripheral blood but not in thymus and mesenteric lymph nodes.	Tacrolimus	113-118	C-X-C motif chemokine ligand 8	Homo sapiens	75-88
11156586-0	2001	N-acetylcysteine attenuates TNF-alpha-induced p38 MAP kinase activation and p38 MAP kinase-mediated IL-8 production by human pulmonary vascular endothelial cells.	Acetylcysteine	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
11156586-4	2001	However, the effect of N-acetylcysteine (NAC), which acts as a precursor of glutathione (GSH) synthesis, on TNF-alpha-induced activation of p38 MAP kinase pathway and p38 MAP kinase-mediated IL-8 production by human pulmonary vascular endothelial cells has not been determined.	Acetylcysteine	23-39	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
11156586-4	2001	However, the effect of N-acetylcysteine (NAC), which acts as a precursor of glutathione (GSH) synthesis, on TNF-alpha-induced activation of p38 MAP kinase pathway and p38 MAP kinase-mediated IL-8 production by human pulmonary vascular endothelial cells has not been determined.	Acetylcysteine	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
11156586-7	2001	Human pulmonary vascular endothelial cells that had been preincubated with NAC were stimulated with TNF-alpha and then the activation of p38 MAP kinase and MKK3/MKK6 in the cells and IL-8 concentrations in the culture supernatants were determined.	Acetylcysteine	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
11156586-13	2001	NAC attenuated p38 MAP kinase-mediated IL-8 production by TNF-alpha-stimulated cells.	Acetylcysteine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
11156586-15	2001	These results indicate that the cellular reduction and oxidation (redox) regulated by intracellular GSH is critical for TNF-alpha-induced activation of p38 MAP kinase pathway and p38 MAP kinase-mediated IL-8 production by human pulmonary vascular endothelial cells, and we emphasize that anti-oxidant therapy is an important strategy for the treatment of acute lung injury.	Glutathione	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
11340307-0	2001	1,25-dihydroxyvitamin D3 differentially regulates IL-1alpha-stimulated IL-8 and MCP-1 mRNA expression and chemokine secretion by human primary proximal tubular epithelial cells.	Calcitriol	0-24	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
11855786-13	2001	Increased production of IL-6 and IL-8 might have contributed to abnormalities in iron metabolism and it is probably due to overstimulation of macrophages.	Iron	81-85	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
11746504-1	2001	The results reported here show that sodium fluoride (NaF) at low concentration (up to 10 microM) increased four times the proliferation rate of avian osteoblasts in culture.	Sodium Fluoride	36-51	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
11746504-3	2001	However, NaF decreased the incorporation of 35S-sulfate into proteoglycans (PGs) synthesized by osteoblasts (60-65%).	35s-sulfate	44-55	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
11746504-4	2001	Also, we observed that PGs synthesized in the presence of NaF (50 microM) exhibited a higher sensitivity to chondroitinase ABC than PGs synthesized by osteoblasts in the absence of NaF, suggesting an increase in the chondroitin sulfate moieties associated with the core protein of PGs.	Chondroitin Sulfates	216-235	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
12094614-5	2001	Vitamin E (d-alpha-tocopherol, 40 microM) in the culture media significantly reduced IL-8 production and angiogenesis.	alpha-Tocopherol	11-29	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
12094614-6	2001	Among the green tea catechins, epigallocatechin (0.5-1 microM) was the most effective in reducing IL-8 production and inhibiting angiogenesis.	Catechin	20-29	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
12094614-6	2001	Among the green tea catechins, epigallocatechin (0.5-1 microM) was the most effective in reducing IL-8 production and inhibiting angiogenesis.	gallocatechol	31-47	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
12094614-7	2001	These results suggest that consumption of green tea catechins or supplemental intake of vitamin E may have preventive effects on tumor development, mediated, at least in part, through inhibition of angiogenesis via suppression of IL-8 production.	Catechin	52-61	C-X-C motif chemokine ligand 8	Homo sapiens	230-234
12094614-7	2001	These results suggest that consumption of green tea catechins or supplemental intake of vitamin E may have preventive effects on tumor development, mediated, at least in part, through inhibition of angiogenesis via suppression of IL-8 production.	Vitamin E	88-97	C-X-C motif chemokine ligand 8	Homo sapiens	230-234
11845301-5	2001	Interestingly, treatment of CF gland cells with the isoflavone genistein, a well known CFTR mutant Cl(-) channel stimulator, results in a significant decrease ( P &lt; 0.001) in IL-8 production down to levels released by non-CF gland cells.	Isoflavones	52-62	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
11845301-5	2001	Interestingly, treatment of CF gland cells with the isoflavone genistein, a well known CFTR mutant Cl(-) channel stimulator, results in a significant decrease ( P &lt; 0.001) in IL-8 production down to levels released by non-CF gland cells.	Genistein	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
11382084-2	2001	One such additive is sodium fluoride (NaF), which promotes bone formation, facilitating implant integration and success.	Sodium Fluoride	21-36	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
11076803-3	2000	Sepharose-immobilized IL-8 stimulated a sevenfold increase in IL-8 production within 2 h. IL-8 induced the expression of its own message, and IL-8 biosynthesis was inhibited by cycloheximide and actinomycin D, indicating de novo RNA and protein synthesis.	Sepharose	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
11076803-3	2000	Sepharose-immobilized IL-8 stimulated a sevenfold increase in IL-8 production within 2 h. IL-8 induced the expression of its own message, and IL-8 biosynthesis was inhibited by cycloheximide and actinomycin D, indicating de novo RNA and protein synthesis.	Sepharose	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
11076803-3	2000	Sepharose-immobilized IL-8 stimulated a sevenfold increase in IL-8 production within 2 h. IL-8 induced the expression of its own message, and IL-8 biosynthesis was inhibited by cycloheximide and actinomycin D, indicating de novo RNA and protein synthesis.	Sepharose	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
11076803-3	2000	Sepharose-immobilized IL-8 stimulated a sevenfold increase in IL-8 production within 2 h. IL-8 induced the expression of its own message, and IL-8 biosynthesis was inhibited by cycloheximide and actinomycin D, indicating de novo RNA and protein synthesis.	Sepharose	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
11076803-3	2000	Sepharose-immobilized IL-8 stimulated a sevenfold increase in IL-8 production within 2 h. IL-8 induced the expression of its own message, and IL-8 biosynthesis was inhibited by cycloheximide and actinomycin D, indicating de novo RNA and protein synthesis.	Cycloheximide	177-190	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
11076803-3	2000	Sepharose-immobilized IL-8 stimulated a sevenfold increase in IL-8 production within 2 h. IL-8 induced the expression of its own message, and IL-8 biosynthesis was inhibited by cycloheximide and actinomycin D, indicating de novo RNA and protein synthesis.	Cycloheximide	177-190	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
11076803-3	2000	Sepharose-immobilized IL-8 stimulated a sevenfold increase in IL-8 production within 2 h. IL-8 induced the expression of its own message, and IL-8 biosynthesis was inhibited by cycloheximide and actinomycin D, indicating de novo RNA and protein synthesis.	Cycloheximide	177-190	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
11076803-3	2000	Sepharose-immobilized IL-8 stimulated a sevenfold increase in IL-8 production within 2 h. IL-8 induced the expression of its own message, and IL-8 biosynthesis was inhibited by cycloheximide and actinomycin D, indicating de novo RNA and protein synthesis.	Cycloheximide	177-190	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
11076803-3	2000	Sepharose-immobilized IL-8 stimulated a sevenfold increase in IL-8 production within 2 h. IL-8 induced the expression of its own message, and IL-8 biosynthesis was inhibited by cycloheximide and actinomycin D, indicating de novo RNA and protein synthesis.	Dactinomycin	195-208	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
11076803-3	2000	Sepharose-immobilized IL-8 stimulated a sevenfold increase in IL-8 production within 2 h. IL-8 induced the expression of its own message, and IL-8 biosynthesis was inhibited by cycloheximide and actinomycin D, indicating de novo RNA and protein synthesis.	Dactinomycin	195-208	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
11076803-3	2000	Sepharose-immobilized IL-8 stimulated a sevenfold increase in IL-8 production within 2 h. IL-8 induced the expression of its own message, and IL-8 biosynthesis was inhibited by cycloheximide and actinomycin D, indicating de novo RNA and protein synthesis.	Dactinomycin	195-208	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
11076803-3	2000	Sepharose-immobilized IL-8 stimulated a sevenfold increase in IL-8 production within 2 h. IL-8 induced the expression of its own message, and IL-8 biosynthesis was inhibited by cycloheximide and actinomycin D, indicating de novo RNA and protein synthesis.	Dactinomycin	195-208	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
11076803-6	2000	The involvement of mitogen-activated protein kinase (MAPK) in IL-8-induced IL-8 biosynthesis was suggested by the ability of PD-98059, an inhibitor of MAPK kinase, to block this function.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	125-133	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
11076803-6	2000	The involvement of mitogen-activated protein kinase (MAPK) in IL-8-induced IL-8 biosynthesis was suggested by the ability of PD-98059, an inhibitor of MAPK kinase, to block this function.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	125-133	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
11218494-10	2000	Our data indicate that the fluoride release from the resin-modified glass ionomer studied may be increased after treatment with an acidified NaF-toothpaste.	Fluorides	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	141-144
11121511-12	2000	On the other hand, in certain local responses, and under certain conditions, catecholamines may actually boost regional immune responses, through induction of IL-1, tumor necrosis factor-alpha, and primarily IL-8 production.	Catecholamines	77-91	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
11137464-4	2000	Two different fractions (ethanol or chloroform soluble extracts) of CSE with their chemical types identified showed a time- and dose-dependent increase on IL-8 secretion from ECV304 cell line.	Ethanol	25-32	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
11137464-4	2000	Two different fractions (ethanol or chloroform soluble extracts) of CSE with their chemical types identified showed a time- and dose-dependent increase on IL-8 secretion from ECV304 cell line.	Chloroform	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
11083814-5	2000	Furthermore, PMN stimulated by OMV in the presence of IFN-gamma demonstrated an enhanced capacity to release TNF-alpha, IL-1beta, IL-8, and MIP-1beta compared to stimulation with OMV alone.	1-ethylcyclopentyl [(2R,6S,12Z,13aS,14aR,16aS)-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl]carbamate	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
11137464-6	2000	Protein tyrosine kinase (PTK) inhibitor genistein and protein kinase A (PKA) inhibitor H8 at respective concentrations significantly reduced chloroform and ethanol soluble extract-induced IL-8 expression by about 34 and 35% respectively at 8 h after incubation.	N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide	87-89	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
11137464-6	2000	Protein tyrosine kinase (PTK) inhibitor genistein and protein kinase A (PKA) inhibitor H8 at respective concentrations significantly reduced chloroform and ethanol soluble extract-induced IL-8 expression by about 34 and 35% respectively at 8 h after incubation.	Ethanol	156-163	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
11130495-13	2000	PAF priming of IL-8 responses was unaffected by injury.	Platelet Activating Factor	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
11169058-0	2000	Neopterin and interleukin-8--prognosis in alcohol-induced cirrhosis.	Alcohols	42-49	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
11169058-11	2000	CONCLUSIONS: Neopterin and IL-8 plasma levels are raised in patients with alcohol-induced cirrhosis, and are predictive of mortality associated with infections and upper gastrointestinal bleeding, respectively.	Alcohols	74-81	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
11087880-12	2000	In the patients who received methylprednisolone, interleukin-8 concentrations decreased by 50 percent, and this decrease correlated with the duration of neuralgia and with the extent of global pain relief (P&lt;0.001 for both comparisons).	Methylprednisolone	29-47	C-X-C motif chemokine ligand 8	Homo sapiens	49-62
11192539-0	2000	N-acetyl-L-cysteine inhibits bleomycin-induced interleukin-8 secretion by bronchial epithelial cells.	Bleomycin	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	47-60
11192539-6	2000	In the present study, we showed that BLM induced the expression of IL-8 protein and mRNA in BEAS-2B cells, and N-acetyl-L-cysteine (NAC) inhibited IL-8 expression.	Bleomycin	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
11192539-6	2000	In the present study, we showed that BLM induced the expression of IL-8 protein and mRNA in BEAS-2B cells, and N-acetyl-L-cysteine (NAC) inhibited IL-8 expression.	Bleomycin	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
11192539-7	2000	In addition, the structurally unrelated antioxidant, pyrrolidine dithiocarbamate (PDTC) also effectively inhibited BLM-induced IL-8 production.	pyrrolidine dithiocarbamic acid	53-80	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
11192539-7	2000	In addition, the structurally unrelated antioxidant, pyrrolidine dithiocarbamate (PDTC) also effectively inhibited BLM-induced IL-8 production.	pyrrolidine dithiocarbamic acid	82-86	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
11119262-0	2000	Enprostil, a prostaglandin-E(2) analogue, inhibits interleukin-8 production of human colonic epithelial cell lines.	Enprostil	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
11119262-5	2000	Furthermore, 10(-6) M enprostil suppressed IL-8 production in HT-29 cells, SW620 and CaCo2 stimulated with interleukin-1 beta (IL-1 beta) or lipopolysaccharide (LPS), but did not suppress this response when cells were stimulated with tumour necrosis factor (TNF)-alpha.	Enprostil	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
11084285-4	2000	Release of IL-8 was down-regulated by transforming growth factor beta2 (TGF-beta2), by the protein tyrosine-kinase inhibitor genistein, and via rises in intracellular cyclic AMP, generated by prostaglandin E(2), rolipram, pentoxifylline, forskolin, or dibutyryl-cyclic AMP.	Pentoxifylline	222-236	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
11084285-4	2000	Release of IL-8 was down-regulated by transforming growth factor beta2 (TGF-beta2), by the protein tyrosine-kinase inhibitor genistein, and via rises in intracellular cyclic AMP, generated by prostaglandin E(2), rolipram, pentoxifylline, forskolin, or dibutyryl-cyclic AMP.	Genistein	125-134	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
11084285-4	2000	Release of IL-8 was down-regulated by transforming growth factor beta2 (TGF-beta2), by the protein tyrosine-kinase inhibitor genistein, and via rises in intracellular cyclic AMP, generated by prostaglandin E(2), rolipram, pentoxifylline, forskolin, or dibutyryl-cyclic AMP.	Colforsin	238-247	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
11084285-4	2000	Release of IL-8 was down-regulated by transforming growth factor beta2 (TGF-beta2), by the protein tyrosine-kinase inhibitor genistein, and via rises in intracellular cyclic AMP, generated by prostaglandin E(2), rolipram, pentoxifylline, forskolin, or dibutyryl-cyclic AMP.	Cyclic AMP	167-177	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
11084285-4	2000	Release of IL-8 was down-regulated by transforming growth factor beta2 (TGF-beta2), by the protein tyrosine-kinase inhibitor genistein, and via rises in intracellular cyclic AMP, generated by prostaglandin E(2), rolipram, pentoxifylline, forskolin, or dibutyryl-cyclic AMP.	Prostaglandins E	192-207	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
11084285-4	2000	Release of IL-8 was down-regulated by transforming growth factor beta2 (TGF-beta2), by the protein tyrosine-kinase inhibitor genistein, and via rises in intracellular cyclic AMP, generated by prostaglandin E(2), rolipram, pentoxifylline, forskolin, or dibutyryl-cyclic AMP.	Bucladesine	252-272	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
11084285-4	2000	Release of IL-8 was down-regulated by transforming growth factor beta2 (TGF-beta2), by the protein tyrosine-kinase inhibitor genistein, and via rises in intracellular cyclic AMP, generated by prostaglandin E(2), rolipram, pentoxifylline, forskolin, or dibutyryl-cyclic AMP.	Rolipram	212-220	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
11103787-5	2000	We show that thymidine induces oxidative stress in TP-overexpressing carcinoma cells, promoting secretion of the stress-induced angiogenic factors vascular endothelial growth factor and interleukin-8, and inducing matrix metalloproteinase-1.	Thymidine	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	186-199
11084285-5	2000	In addition, incubation with the synthetic glucocorticoid dexamethasone or suppression of activity of p38 mitogen-activated protein (MAP) kinases by SB-203580 modulated release of IL-8.	Dexamethasone	58-71	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
11084285-5	2000	In addition, incubation with the synthetic glucocorticoid dexamethasone or suppression of activity of p38 mitogen-activated protein (MAP) kinases by SB-203580 modulated release of IL-8.	SB 203580	149-158	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
11293246-6	2000	Thanks to clinical studies it has been performed that MTX holds up activity and productions of Il-8, releasing of TNF-alpha and reduction of concentration Il-6.	Methotrexate	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
11048965-0	2000	Effect of phenytoin on the production of interleukin-6 and interleukin-8 in human gingival fibroblasts.	Phenytoin	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	59-72
11046208-12	2000	Plasma IL-8 at 2 h correlated with NAG/creatinine at 6 h (P &lt; 0.05).	Creatinine	39-49	C-X-C motif chemokine ligand 8	Homo sapiens	7-11
11069840-5	2000	IL-8 mRNA expression was significantly greater in tumor tissue; high expression was highly associated with tumor in advanced stages (p = 0.03), distant lymph node metastasis (p = 0.02), high tumor MC (&gt; 123) (p = 0.00003), short survival (&lt; 26 mo) (p &lt; 0.00001), and early relapse (&lt; 16 mo) (p &lt; 0.00001).	Methylcholanthrene	197-199	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
11050002-6	2000	Studies on the mechanism of KS tumor growth inhibition by 1alpha,25 dihydroxyvitamin D(3) showed that production of autocrine growth factors interleukin (IL)-6 and IL-8 was reduced in a dose-dependent manner, whereas no effect was observed on vascular endothelial growth factor and basic fibroblast growth factor.	1,25-dihydroxyvitamin D	58-86	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
12845334-3	2000	In addition, IL-8 release from eosinophils was inhibited by epinastine posttranscriptionally.	epinastine	60-70	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
11053033-3	2000	Triptolide, with an IC(50) of approximately 20-50 ng/ml, inhibits normal and transformed human bronchial epithelial cell expression of interleukin (IL)-6 and IL-8 stimulated by phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-alpha, or IL-1 beta.	triptolide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
11053033-3	2000	Triptolide, with an IC(50) of approximately 20-50 ng/ml, inhibits normal and transformed human bronchial epithelial cell expression of interleukin (IL)-6 and IL-8 stimulated by phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-alpha, or IL-1 beta.	Tetradecanoylphorbol Acetate	177-208	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
11053033-4	2000	Nuclear runoff and luciferase reporter gene assays demonstrate that triptolide inhibits IL-8 transcription.	triptolide	68-78	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
11053033-6	2000	A cDNA array and clustering algorithm analysis reveals that triptolide inhibits expression of the PMA-induced genes tumor necrosis factor-alpha, IL-8, macrophage inflammatory protein-2 alpha, intercellular adhesion molecule-1, integrin beta(6), vascular endothelial growth factor, granulocyte-macrophage colony-stimulating factor, GATA-3, fra-1, and NF45.	triptolide	60-70	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
11052920-6	2000	Ciprofloxacin decreased IL-6 mRNA (P&lt;0.05) and increased IL-8 mRNA (P&lt;0.05) expression.	Ciprofloxacin	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
11052920-10	2000	Increased IL-8 mRNA in response to ciprofloxacin was not reflected by altered transcription factor activation and may represent increased mRNA stability.	Ciprofloxacin	35-48	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
11246821-6	2000	Ciglitazone 10-100 M inhibited interleukin-8 release by 25-33% (p &lt; 0.05) and mRNA expression by 33-60% (p &lt; 0.05).	ciglitazone	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	31-44
11246821-7	2000	Metformin 0.1-10 mM inhibited interleukin-8 release by 20-50% (p &lt; 0.05) and mRNA expression by 20-90% (p &lt; 0.05).	Metformin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
11046054-4	2000	Rhinovirus infection induced a time- and dose-dependent increase in tyrosine phosphorylation of p38 kinase, which peaked 30 min postinfection and remained elevated for 1 h. Treatment of infected cells with SB 239063, a potent pyridinyl imidazole inhibitor of p38 kinase, resulted in up to 100% inhibition of mediator production and partially reduced levels of IL-8 mRNA as determined by quantitative RT-PCR.	SB 239063	206-215	C-X-C motif chemokine ligand 8	Homo sapiens	360-364
11053499-0	2000	Medium- and long-chain fatty acids differentially modulate interleukin-8 secretion in human fetal intestinal epithelial cells.	medium- and long-chain fatty acids	0-34	C-X-C motif chemokine ligand 8	Homo sapiens	59-72
11053499-3	2000	In the present study, we evaluated the effects of medium-chain and long-chain fatty acids (MCFA and LCFA) on interleukin (IL)-8 secretion in a fetal intestinal epithelial cell line, intestine-407 cells.	and long-chain fatty acids	63-89	C-X-C motif chemokine ligand 8	Homo sapiens	109-127
11053499-3	2000	In the present study, we evaluated the effects of medium-chain and long-chain fatty acids (MCFA and LCFA) on interleukin (IL)-8 secretion in a fetal intestinal epithelial cell line, intestine-407 cells.	mcfa	91-95	C-X-C motif chemokine ligand 8	Homo sapiens	109-127
11053499-6	2000	The addition of oleic acid (LCFA) micelles, but not octanoic acid (MCFA) micelles, weakly but significantly enhanced basal IL-8 secretion in the intestine-407 cells.	Oleic Acid	16-26	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
11048965-1	2000	The in vitro effect of phenytoin (PHT) on the production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in human gingival fibroblasts, challenged with or without interleukin-1beta (IL-1beta), was studied.	Phenytoin	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	85-98
11053499-6	2000	The addition of oleic acid (LCFA) micelles, but not octanoic acid (MCFA) micelles, weakly but significantly enhanced basal IL-8 secretion in the intestine-407 cells.	lcfa	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
11048965-1	2000	The in vitro effect of phenytoin (PHT) on the production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in human gingival fibroblasts, challenged with or without interleukin-1beta (IL-1beta), was studied.	Phenytoin	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
11053499-7	2000	The addition of MCFA (5 mmol/L) induced a 40% increase in IL-1beta-induced IL-8 secretion and a 35% increase in tumor necrosis factor (TNF)-alpha-induced IL-8 secretion, respectively.	mcfa	16-20	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
11053499-7	2000	The addition of MCFA (5 mmol/L) induced a 40% increase in IL-1beta-induced IL-8 secretion and a 35% increase in tumor necrosis factor (TNF)-alpha-induced IL-8 secretion, respectively.	mcfa	16-20	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
11048965-4	2000	The anti-inflammatory drug, dexamethasone (1 microM), abolished the production of both IL-6 and IL-8 in gingival fibroblasts challenged with PHT in the presence or absence of IL-1beta.	Dexamethasone	28-41	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
11048965-4	2000	The anti-inflammatory drug, dexamethasone (1 microM), abolished the production of both IL-6 and IL-8 in gingival fibroblasts challenged with PHT in the presence or absence of IL-1beta.	Phenytoin	141-144	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
11030960-0	2000	Observation of anti-stokes fluorescence cooling in thulium-doped glass We report the first observation of anti-Stokes fluorescence cooling in a thulium-doped solid with pump excitation at 1.82 &amp;mgr;m&lt;lambda&lt;1.97 &amp;mgr;m. At a pump wavelength of 1.9 &amp;mgr;m and incident average power of approximately 3 W, a Tm3+:ZBLANP ( ZrF4-BaF2-LaF3-AlF3-NaF-PbF2) sample cooled to -1.2 degrees C from room temperature for a single pass of the pump beam.	Thulium	51-58	C-X-C motif chemokine ligand 8	Homo sapiens	358-361
11069732-13	2000	As previously reported, the inhibition of NO synthesis by the competitive inhibitor L-NMMA led to enhancement of IL-6, IL-8 and PGE(2)production by IL-1 beta treated chondrocytes, but did not significantly modify IL-10, PG and MMP-3 productions.	omega-N-Methylarginine	84-90	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
11105996-7	2000	Inclusion of 5/1000 (86 mM) ethanol in the medium reduced tumour necrosis factor (TNF)-alpha and interleukin (IL)-8 production in human mast cell line (HMC-1) cells by 55 +/- 7% and 19 +/- 5%, respectively, and the presence of 20/1000 (344 mM) ethanol inhibited the expression 81 +/- 12% and 59 +/- 14% respectively.	Ethanol	28-35	C-X-C motif chemokine ligand 8	Homo sapiens	97-115
11030960-0	2000	Observation of anti-stokes fluorescence cooling in thulium-doped glass We report the first observation of anti-Stokes fluorescence cooling in a thulium-doped solid with pump excitation at 1.82 &amp;mgr;m&lt;lambda&lt;1.97 &amp;mgr;m. At a pump wavelength of 1.9 &amp;mgr;m and incident average power of approximately 3 W, a Tm3+:ZBLANP ( ZrF4-BaF2-LaF3-AlF3-NaF-PbF2) sample cooled to -1.2 degrees C from room temperature for a single pass of the pump beam.	Thulium	144-151	C-X-C motif chemokine ligand 8	Homo sapiens	358-361
11037876-0	2000	The mechanism of taurine chloramine inhibition of cytokine (interleukin-6, interleukin-8) production by rheumatoid arthritis fibroblast-like synoviocytes.	chloramine	25-35	C-X-C motif chemokine ligand 8	Homo sapiens	75-88
11031216-10	2000	Incubation of ECs with N:-acetyl cysteine inhibited production of IL-8 and MCP-1 induced by LDL(-) and oxLDL by &gt;50%.	Acetylcysteine	23-41	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
11196946-0	2000	Matrix-isolated Al2OF6(2-) ion in molten and solid LiF/NaF/KF.	al2of6(2-)	16-26	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
11196946-1	2000	A Raman spectrum consistent with that expected from an Al2OF6(2-) ion was observed when Na2O was dissolved in a eutectic LiF/NaF/KF (FLINAK) melt at 500 degrees C, which contained a low concentration of either AlF3 or Na3AlF6.	sodium oxide	88-92	C-X-C motif chemokine ligand 8	Homo sapiens	125-128
11031216-9	2000	Actinomycin D inhibited the release of IL-8 and MCP-1 induced by LDL(-) and oxLDL by up to 80%, indicating that their production is mediated by protein synthesis.	Dactinomycin	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
11037876-1	2000	OBJECTIVE: Taurine chloramine (Tau-Cl) has been shown to inhibit the production of proinflammatory cytokines (interleukin-6 [IL-6] and IL-8) by fibroblast-like synoviocytes (FLS) isolated from rheumatoid arthritis (RA) patients.	Taurine	11-18	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
11037876-1	2000	OBJECTIVE: Taurine chloramine (Tau-Cl) has been shown to inhibit the production of proinflammatory cytokines (interleukin-6 [IL-6] and IL-8) by fibroblast-like synoviocytes (FLS) isolated from rheumatoid arthritis (RA) patients.	chloramine	19-29	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
11037876-1	2000	OBJECTIVE: Taurine chloramine (Tau-Cl) has been shown to inhibit the production of proinflammatory cytokines (interleukin-6 [IL-6] and IL-8) by fibroblast-like synoviocytes (FLS) isolated from rheumatoid arthritis (RA) patients.	N-chlorotaurine	31-37	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
11032978-2	2000	METHODS: To test this hypothesis, the beta-adrenergic agonist, isoproterenol, and the G protein activator, sodium fluoride (NaF), were used to stimulate cAMP production in B lymphoblasts from healthy and BP-I subjects phenotyped on basal intracellular calcium concentration ([Ca(2+)](B)).	Sodium Fluoride	107-122	C-X-C motif chemokine ligand 8	Homo sapiens	124-127
11032978-2	2000	METHODS: To test this hypothesis, the beta-adrenergic agonist, isoproterenol, and the G protein activator, sodium fluoride (NaF), were used to stimulate cAMP production in B lymphoblasts from healthy and BP-I subjects phenotyped on basal intracellular calcium concentration ([Ca(2+)](B)).	Cyclic AMP	153-157	C-X-C motif chemokine ligand 8	Homo sapiens	124-127
11037876-3	2000	METHODS: The effects of Tau-Cl on 1) the transcription of genes coding for IL-6 and IL-8, and 2) the activity of nuclear factor kappaB (NF-kappaB) and activator protein 1 (AP-1) transcription factors, which are crucial for the transcription of these cytokine genes, were investigated in FLS isolated from the synovial tissue of RA patients.	N-chlorotaurine	24-30	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
11032978-5	2000	Although basal and NaF-stimulated cAMP production was greater in B lymphoblast membranes from male BP-I patients with high versus normal [Ca(2+)](B), there were no differences in the percent stimulation.	Cyclic AMP	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
11037876-8	2000	Tau-Cl, but not Tau, reduced IL-1beta-triggered cytokine mRNA expression, exerting stronger inhibitory activity on the levels of IL-6 than on those of IL-8.	N-chlorotaurine	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
11037876-0	2000	The mechanism of taurine chloramine inhibition of cytokine (interleukin-6, interleukin-8) production by rheumatoid arthritis fibroblast-like synoviocytes.	Taurine	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	75-88
11079780-8	2000	R-838 also inhibited interleukin-8 release from HBECs.	r-838	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	21-34
11012615-8	2000	The induction of IL-8 mRNA by poly-L-arginine was significantly inhibited by actinomycin D.	polyarginine	30-45	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
11012615-8	2000	The induction of IL-8 mRNA by poly-L-arginine was significantly inhibited by actinomycin D.	Dactinomycin	77-90	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
11023990-13	2000	IL-8 and SDF-1alpha but not IP-10 induced calcium mobilization in adherent ECs, suggesting that signaling events associated with calcium mobilization are separable from those required for chemotaxis.	Calcium	129-136	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10979935-4	2000	The present study demonstrates that amphotericin B increases mRNA for the chemokines interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1beta, as well as the cell adhesion molecules intercellular adhesion molecule (ICAM)-1 and CD44 in the human monocytic cell line THP-1.	Amphotericin B	36-50	C-X-C motif chemokine ligand 8	Homo sapiens	85-103
10979935-5	2000	Amphotericin B increased the concentrations of IL-8, MCP-1, and MIP-1beta in a dose-dependent fashion.	Amphotericin B	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
11037761-6	2000	None or weakly toxic concentrations of Ni and Co chloride induced IL-6 and IL-8 release by a factor of 5-10 compared to controls.	co chloride	46-57	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
10979965-8	2000	Secretion of IL-8 reached a plateau level in less than 24 hours, was inhibited by cycloheximide, and required the presence of HrHRF throughout the culture period.	Cycloheximide	82-95	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
11027515-0	2000	Reactive oxygen intermediates are involved in IL-8 production induced by hyperosmotic stress in human bronchial epithelial cells.	reactive oxygen	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
11027515-3	2000	Hyperosmolarity (NaCl) caused a time- and concentration-dependent increase in IL-8 expression and secretion in bronchial epithelial cells.	Sodium Chloride	17-21	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
11027515-4	2000	These effects could be blocked by antioxidants, such as DMSO, DMTU, DTT, and beta-mercaptoethanol, suggesting an involvement of reactive oxygen intermediates (ROI) in the signal transduction of hyperosmolarity-induced IL-8 synthesis.	Mercaptoethanol	77-97	C-X-C motif chemokine ligand 8	Homo sapiens	218-222
10982368-9	2000	Tat(72aa)-mediated MCP-1 and IL-8 mRNA induction was susceptible to inhibition by the MEK1/2 inhibitor UO126 but was only modestly decreased by the inclusion of the p38 mitogen-activated protein kinase (MAPK) inhibitor SB202190.	U 0126	103-108	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
10982368-9	2000	Tat(72aa)-mediated MCP-1 and IL-8 mRNA induction was susceptible to inhibition by the MEK1/2 inhibitor UO126 but was only modestly decreased by the inclusion of the p38 mitogen-activated protein kinase (MAPK) inhibitor SB202190.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	219-227	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
11015126-0	2000	Effects of early inhaled beclomethasone therapy on tracheal aspirate inflammatory mediators IL-8 and IL-1ra in ventilated preterm infants at risk for bronchopulmonary dysplasia.	Beclomethasone	25-39	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
11015126-7	2000	Median IL-8 levels were lower in beclomethasone versus placebo infants on study days 8 (82.9 vs. 209.2, P &lt; 0.01) and 15 (37.4 vs. 77.4, P &lt; 0.03) after controlling for antenatal glucocorticoid therapy and maternal race.	Beclomethasone	33-47	C-X-C motif chemokine ligand 8	Homo sapiens	7-11
11015126-9	2000	Fewer beclomethasone infants with baseline IL-8 levels in the interquartile range required systemic glucocorticoid therapy (beclomethasone 30.6% vs. placebo 65.8%, P &lt; 0.01) or developed BPD (beclomethasone 42.4% vs. placebo 69.4%, P &lt; 0.03).	Beclomethasone	6-20	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
11015126-11	2000	Beclomethasone-treated infants with moderately elevated baseline IL-8 levels received less subsequent systemic glucocorticoid therapy and had a lower incidence of BPD than nontreated infants.	Beclomethasone	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
11175566-1	2000	OBJECTIVE: The aims of this article are to verify if there is any alteration in the secretion of natriuretic atrial factor (NAF) in children submitted to mechanical pulmonary ventilation and if these possible alterations would lead to modification in the urinary volume and in the urinary sodium excretion.	Sodium	289-295	C-X-C motif chemokine ligand 8	Homo sapiens	97-122
11175566-1	2000	OBJECTIVE: The aims of this article are to verify if there is any alteration in the secretion of natriuretic atrial factor (NAF) in children submitted to mechanical pulmonary ventilation and if these possible alterations would lead to modification in the urinary volume and in the urinary sodium excretion.	Sodium	289-295	C-X-C motif chemokine ligand 8	Homo sapiens	124-127
10988245-0	2000	Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells.	Phospholipids	70-82	C-X-C motif chemokine ligand 8	Homo sapiens	139-152
10988245-3	2000	In the present study, we demonstrate that MM-LDL and oxidation products of 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine (PAPC) activate endothelial cells to synthesize monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8).	PC(16:0/20:0)	75-128	C-X-C motif chemokine ligand 8	Homo sapiens	220-233
10988245-3	2000	In the present study, we demonstrate that MM-LDL and oxidation products of 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine (PAPC) activate endothelial cells to synthesize monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8).	PC(16:0/20:0)	75-128	C-X-C motif chemokine ligand 8	Homo sapiens	235-239
10988245-3	2000	In the present study, we demonstrate that MM-LDL and oxidation products of 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine (PAPC) activate endothelial cells to synthesize monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8).	PAPC	130-134	C-X-C motif chemokine ligand 8	Homo sapiens	220-233
10975802-8	2000	Octreotide, which mainly stimulates somatostatin receptor subtypes 2 and 5, affected the secretion of IL-8 and IL-1beta similarly, and the somatostatin antagonist cyclo-somatostatin completely blocked the somatostatin- and octreotide-induced inhibitory effects.	Octreotide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
10988245-3	2000	In the present study, we demonstrate that MM-LDL and oxidation products of 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine (PAPC) activate endothelial cells to synthesize monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8).	PAPC	130-134	C-X-C motif chemokine ligand 8	Homo sapiens	235-239
10988245-7	2000	By contrast, troglitazone, a PPARgamma agonist, decreased the levels of IL-8 and MCP-1.	Troglitazone	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
10984371-9	2000	RESULTS: Calcium influx was induced by monocyte chemotactic protein (MCP) 1, MCP-3, MCP-4, RANTES, eotaxin, IL-8, and stromal cell-derived factor 1alpha, which are chemokines that bind several chemokine receptors.	Calcium	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
11014907-1	2000	Sodium monofluorophosphate (NaMFP) and sodium fluoride (NaF) are the two most common sources of fluoride used in currently marketed fluoride dentifrices.	Sodium Fluoride	39-54	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
11014907-1	2000	Sodium monofluorophosphate (NaMFP) and sodium fluoride (NaF) are the two most common sources of fluoride used in currently marketed fluoride dentifrices.	Fluorides	46-54	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
11014907-1	2000	Sodium monofluorophosphate (NaMFP) and sodium fluoride (NaF) are the two most common sources of fluoride used in currently marketed fluoride dentifrices.	Fluorides	96-104	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
11014907-2	2000	The purpose of this study was to investigate the effect of mouth rinses containing NaF or NaMFP on the concentrations of fluoride, or the MFP ion, in saliva, whole plaque, and plaque fluid.	Fluorides	121-129	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
11014907-10	2000	Although there was a very large range in these measurements, fluoride in plaque fluid (excluding fluoride in unhydrolyzed MFP) and whole plaque were significantly (p&lt;0.05) greater after the NaF rinse at all time periods.	Fluorides	61-69	C-X-C motif chemokine ligand 8	Homo sapiens	193-196
11014907-11	2000	In saliva, the NaF rinse produced a statistically significant greater salivary fluoride (excluding fluoride in unhydrolyzed MFP) only at 60 min.	Fluorides	79-87	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
11014907-11	2000	In saliva, the NaF rinse produced a statistically significant greater salivary fluoride (excluding fluoride in unhydrolyzed MFP) only at 60 min.	Fluorides	99-107	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
10976010-6	2000	Serum IL-8 values increased after alcohol intake in healthy subjects.	Alcohols	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
11022126-3	2000	Control experiments revealed that 10- 6 M dexamethasone inhibited the TNF-alpha- or IL-1beta-mediated increase of IL-8 mRNA in A549 cells, which showed that the glucocorticoid was functional.	Dexamethasone	42-55	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
10996027-5	2000	Co-injection of BA with CXC chemokine interleukin-8 (IL-8) into rat skin significantly inhibited IL-8 elicited neutrophil infiltration.	baicalin	16-18	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
10996027-5	2000	Co-injection of BA with CXC chemokine interleukin-8 (IL-8) into rat skin significantly inhibited IL-8 elicited neutrophil infiltration.	baicalin	16-18	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
10996027-7	2000	This conclusion was supported by the fact that BA cross-linked to oxime resin bound chemokines of the CXC (stromal cell-derived factor (SDF)-1alpha, IL-8), CC (macrophage inflammatory protein (MIP)-1beta, monocyte chemotactic protein (MCP)-2), and C (lymphotactin (Ltn)) subfamilies.	baicalin	47-49	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
10996027-7	2000	This conclusion was supported by the fact that BA cross-linked to oxime resin bound chemokines of the CXC (stromal cell-derived factor (SDF)-1alpha, IL-8), CC (macrophage inflammatory protein (MIP)-1beta, monocyte chemotactic protein (MCP)-2), and C (lymphotactin (Ltn)) subfamilies.	Oximes	66-71	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
10975857-2	2000	We evaluated the role of NF-kappaB in HRV-16-induced IL-8 and IL-6 production by EMSA using oligonucleotides corresponding to the binding sites for NF-kappaB in the IL-6 and IL-8 gene promoters.	Oligonucleotides	92-108	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
10975857-3	2000	Consistent with the rapid induction of mRNA for IL-8 and IL-6, maximal NF-kappaB binding to both oligonucleotides was detected at 30 min after infection.	Oligonucleotides	97-113	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
10975857-5	2000	The IL-8 oligonucleotide bound recombinant p50 with only about one-tenth the efficiency of the IL-6 oligonucleotide, even though epithelial cells produced more IL-8 protein than IL-6.	Oligonucleotides	9-24	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
10975857-5	2000	The IL-8 oligonucleotide bound recombinant p50 with only about one-tenth the efficiency of the IL-6 oligonucleotide, even though epithelial cells produced more IL-8 protein than IL-6.	Oligonucleotides	9-24	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
10975857-5	2000	The IL-8 oligonucleotide bound recombinant p50 with only about one-tenth the efficiency of the IL-6 oligonucleotide, even though epithelial cells produced more IL-8 protein than IL-6.	Oligonucleotides	100-115	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
10973631-6	2000	FK506 and cyclosporin A suppressed the chemotactic activity of the supernatant in parallel to the suppression of interleukin-8 production by peripheral blood mononuclear cells.	Tacrolimus	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	113-126
10973631-6	2000	FK506 and cyclosporin A suppressed the chemotactic activity of the supernatant in parallel to the suppression of interleukin-8 production by peripheral blood mononuclear cells.	Cyclosporine	10-23	C-X-C motif chemokine ligand 8	Homo sapiens	113-126
10973631-8	2000	These studies indicate that FK506 may exert a beneficial effect on human inflammatory diseases by suppressing neutrophil chemotaxis secondary to inhibition of chemoattractant (for example, interleukin-8) production by leukocytes.	Tacrolimus	28-33	C-X-C motif chemokine ligand 8	Homo sapiens	189-202
11028659-8	2000	Furthermore, PD98059 or SB203580 significantly suppressed BK-induced IL-6 and IL-8 production and their gene expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
11028659-8	2000	Furthermore, PD98059 or SB203580 significantly suppressed BK-induced IL-6 and IL-8 production and their gene expression.	SB 203580	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
10950803-4	2000	Thalidomide treatment was found to cause potent and selective inhibition of IL-8 production in a dose-responsive manner.	Thalidomide	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
10950803-6	2000	In addition, thalidomide treatment of lipopolysaccharide-stimulated microglia inhibited the activation of protein NF-kappaB, a transcription factor known to be important for IL-8 production.	Thalidomide	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
10950803-7	2000	These results suggest thalidomide could have a therapeutic role in acute bacterial meningitis through inhibition of IL-8-mediated neutrophil chemotaxis.	Thalidomide	22-33	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
10958731-12	2000	In vitro studies demonstrated that SK-N-MC and SK-N-SH cells express low levels of IL-8 under normal conditions and that IL-1beta and tumor necrosis factor-alpha significantly increased expression of IL-8 at 24 and 48 hours.	sk-n-mc	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
10958731-12	2000	In vitro studies demonstrated that SK-N-MC and SK-N-SH cells express low levels of IL-8 under normal conditions and that IL-1beta and tumor necrosis factor-alpha significantly increased expression of IL-8 at 24 and 48 hours.	sk-n	35-39	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
10958731-12	2000	In vitro studies demonstrated that SK-N-MC and SK-N-SH cells express low levels of IL-8 under normal conditions and that IL-1beta and tumor necrosis factor-alpha significantly increased expression of IL-8 at 24 and 48 hours.	sk-n	35-39	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
11108140-3	2000	Activation of heterotrimeric G proteins with NaF resulted in a divergent signaling effect; NaF treatment was sufficient to increase tyrosine phosphorylation levels of some proteins independent of angiotensin II treatment.	Tyrosine	132-140	C-X-C motif chemokine ligand 8	Homo sapiens	91-94
11108140-4	2000	In the same cells, NaF alone had no effect on other cellular proteins, but greatly potentiated the ability of angiotensin II to increase the tyrosine phosphorylation levels of these proteins.	Tyrosine	141-149	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
11108140-6	2000	We found that NaF treatment alone, independent of angiotensin II stimulation, was sufficient to increase the tyrosine phosphorylation levels of paxillin.	Tyrosine	109-117	C-X-C motif chemokine ligand 8	Homo sapiens	14-17
11108140-7	2000	Furthermore, the ability of either NaF and/or angiotensin II to increase tyrosine phosphorylation levels of paxillin is critically dependent on intracellular Ca2+.	Tyrosine	73-81	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
10964761-6	2000	Cotreatment with PDTC and curcumin reduced particle-elicited IL-8 response, whereas cycloheximide caused enhancement of IL-8 mRNA expression in both the quartz- and TiO(2)-treated cells.	Curcumin	26-34	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
10989889-1	2000	Antimony oxide trihalides, SbOX3 molecules, where X = F or Cl have been produced, by means of an on-line process, using antimony trichloride, SbOCl3 as starting material passed over heated silver oxide at 230 degrees C. The antimony oxide trichloride SbOCl3 formed is then reacted with sodium fluoride, NaF at 550 degrees C to produce antimony oxide trifluoride, SbOF3.	antimony oxide trihalides	0-25	C-X-C motif chemokine ligand 8	Homo sapiens	303-306
11028544-11	2000	Incubation of TNFalpha + p38-mitogen-activated protein kinase (MAPK) inhibitor SB202190 increased apoptosis (P &lt; 0.01) and decreased IL-8 production to PMN control.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	79-87	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
11028544-12	2000	To a lesser extent, incubation of TNFalpha with inhibitors to NF-kappaB (SN50) and PI3K (LY294002) also increased apoptosis and decreased IL-8 production (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
11028546-0	2000	Dopamine attenuates the chemoattractant effect of interleukin-8: a novel role in the systemic inflammatory response syndrome.	Dopamine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	50-63
10964761-6	2000	Cotreatment with PDTC and curcumin reduced particle-elicited IL-8 response, whereas cycloheximide caused enhancement of IL-8 mRNA expression in both the quartz- and TiO(2)-treated cells.	Cycloheximide	84-97	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	45-74	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
10956206-3	2000	Additionally, the BTPs show inhibition of IL-4, IL-5, IL-8, and eotaxin production.	btps	18-22	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
10900160-10	2000	We conclude that Na(2)SO(3) can activate human neutrophils and that its proinflammatory potential is further supported by its ability to increase IL-8 production.	sodium sulfite	17-27	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	45-74	C-X-C motif chemokine ligand 8	Homo sapiens	250-254
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	250-254
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	172-175	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	172-175	C-X-C motif chemokine ligand 8	Homo sapiens	250-254
10930303-7	2000	The glucocorticoid dexamethasone and the protein kinase inhibitor staurosporine distinctively inhibited the IL-8 production of MONO-MAC-6 cells.	Dexamethasone	19-32	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
10930303-7	2000	The glucocorticoid dexamethasone and the protein kinase inhibitor staurosporine distinctively inhibited the IL-8 production of MONO-MAC-6 cells.	Staurosporine	66-79	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
10930308-0	2000	Nuclear factor-kappa b activation in silica-induced interleukin 8 production by human bronchial epithelial cells.	Silicon Dioxide	37-43	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
10930308-1	2000	Recent studies indicate that interleukin 8 (IL-8) plays an important role in interstitial lung diseases including silica-induced lung inflammation.	Silicon Dioxide	114-120	C-X-C motif chemokine ligand 8	Homo sapiens	29-42
10930308-1	2000	Recent studies indicate that interleukin 8 (IL-8) plays an important role in interstitial lung diseases including silica-induced lung inflammation.	Silicon Dioxide	114-120	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
10930308-4	2000	The administration of silica induced IL-8 production in BET-1A dose-dependently and time-dependently.	Silicon Dioxide	22-28	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
10930308-5	2000	Northern blot analysis demonstrated that silica upregulated IL-8 expression in BET-1A.	Silicon Dioxide	41-47	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
10951245-5	2000	Treatment of PAF-receptor-expressing KB cells with the metabolically stable PAF receptor agonist carbamoyl-PAF resulted in increased interleukin-8 mRNA and protein, indicating that activation of the epidermal PAF receptor was linked to interleukin-8 production.	carbamoyl-paf	97-110	C-X-C motif chemokine ligand 8	Homo sapiens	133-146
10983632-0	2000	Somatostatin (SOM) and octreotide (OCT) inhibit the secretion of interleukin-8 (IL-8) from human peripheral blood mononuclear cells (PBMC) in vitro.	Octreotide	23-33	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
10983632-0	2000	Somatostatin (SOM) and octreotide (OCT) inhibit the secretion of interleukin-8 (IL-8) from human peripheral blood mononuclear cells (PBMC) in vitro.	Octreotide	23-33	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
10928984-3	2000	The pan-COX inhibitor ketorolac continuously and significantly decreased PGE(2) production and IL-6 and IL-8 levels in all OPC cell lines tested, but did not affect IL-1alpha, GM-CSF levels, or in vitro tumor cell growth.	Ketorolac	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
10983632-0	2000	Somatostatin (SOM) and octreotide (OCT) inhibit the secretion of interleukin-8 (IL-8) from human peripheral blood mononuclear cells (PBMC) in vitro.	Octreotide	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
10983632-0	2000	Somatostatin (SOM) and octreotide (OCT) inhibit the secretion of interleukin-8 (IL-8) from human peripheral blood mononuclear cells (PBMC) in vitro.	Octreotide	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
11008723-14	2000	After stimulation of HPMC, interleukin-8 secretion to the apical compartment increased in a time-dependent fashion, resulting in a gradient between the two chambers.	hydroxypropylmethylcellulose-lactose matrix	21-25	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
10951245-5	2000	Treatment of PAF-receptor-expressing KB cells with the metabolically stable PAF receptor agonist carbamoyl-PAF resulted in increased interleukin-8 mRNA and protein, indicating that activation of the epidermal PAF receptor was linked to interleukin-8 production.	carbamoyl-paf	97-110	C-X-C motif chemokine ligand 8	Homo sapiens	236-249
10951245-8	2000	Similarly, treatment of the PAF-receptor-expressing primary cultures of human keratinocytes or the human epidermal cell line A-431 with carbamoyl-PAF or ultraviolet B radiation resulted in interleukin-8 production that was partially inhibited by PAF receptor antagonists.	carbamoyl-paf	136-149	C-X-C motif chemokine ligand 8	Homo sapiens	189-202
10951249-5	2000	Variable release of tumor necrosis factor-alpha and interleukin-8 from keratinocytes occurred only at toxic threshold concentrations of the phenols or sodium dodecyl sulfate.	Phenols	140-147	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
10951249-5	2000	Variable release of tumor necrosis factor-alpha and interleukin-8 from keratinocytes occurred only at toxic threshold concentrations of the phenols or sodium dodecyl sulfate.	Sodium Dodecyl Sulfate	151-173	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
11030461-1	2000	Naftidrofuryl (Praxilene; NAF) significantly improves claudication distance in patients with peripheral vascular disease (PVD).	Nafronyl	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
10917982-17	2000	Regarding cytokine release, although a tendency toward high tumor necrosis factor alpha and interleukin-8 levels was noticed in the EAAA group, global time course effects failed to reach statistical significance (P =.543 and P =.080).	eaaa	132-136	C-X-C motif chemokine ligand 8	Homo sapiens	92-105
11030461-5	2000	NAF also inhibited (P &lt;0.0001) shape change (PSC; an early phase of platelet activation, characterised by an increase in MPV) induced by ET-1 (0.4 micromol/l) in combination with ADP (0.05-0.15 micromol/l) or serotonin (0.03-0.13 micromol/ l).	Adenosine Diphosphate	182-185	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
11030461-5	2000	NAF also inhibited (P &lt;0.0001) shape change (PSC; an early phase of platelet activation, characterised by an increase in MPV) induced by ET-1 (0.4 micromol/l) in combination with ADP (0.05-0.15 micromol/l) or serotonin (0.03-0.13 micromol/ l).	Serotonin	212-221	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
11778258-5	2000	Compared with the HNS group, there was a significant increase in the PMN and the level of IL-8 in the HS group (P &lt; 0.05).	hassio	102-104	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
11778258-8	2000	In the HS group the sputum level of IL-8 was also correlated positively with the PMN (rs = 0.8424).	hassio	7-9	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
10893219-4	2000	Maximal IL-8 release was achieved with 10 ng/ml of TGF-beta1 after 16 h of incubation, which was inhibited by the transcription inhibitor actinomycin D and the corticosteroid dexamethasone but was not affected by the nonselective COX inhibitor indomethacin and the selective COX-2 inhibitor NS-398 despite their inhibition on TGF-beta1-induced PGE(2) release.	Dactinomycin	138-151	C-X-C motif chemokine ligand 8	Homo sapiens	8-12
10887141-5	2000	Fibroblasts grown from synovial and peritoneal tissues displayed C5a/IL-8-inhibitor activity that could be further induced with phorbol myristate acetate (PMA) and IL-1 beta.	Tetradecanoylphorbol Acetate	128-153	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
10887141-5	2000	Fibroblasts grown from synovial and peritoneal tissues displayed C5a/IL-8-inhibitor activity that could be further induced with phorbol myristate acetate (PMA) and IL-1 beta.	Tetradecanoylphorbol Acetate	155-158	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
10873156-0	2000	Synergistic inhibition by beta(2)-agonists and corticosteroids on tumor necrosis factor-alpha-induced interleukin-8 release from cultured human airway smooth-muscle cells.	beta(2)	26-33	C-X-C motif chemokine ligand 8	Homo sapiens	102-115
10873156-2	2000	Here, we tested the effects of the beta(2)-agonists salbutamol (Salbu) and salmeterol (Salme) on IL-8 release and tumor necrosis factor (TNF)-alpha-induced IL-8 release from ASM cells.	beta(2)	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
10933164-9	2000	In contrast, IL-8 mRNA expression of bronchial cells was significantly higher in the BOS group (0.85+/-0.40 vs. 0.22+/-0.10 O.D./O.D.	N-[4-(Aminosulfonyl)phenyl]-2-Mercaptobenzamide	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
10873668-7	2000	The lack of the chemokine binding was not likely to be due to the lack of glycosylation of the Fy/GPA, since IL-8 was effectively bound to de-N-glycosylated erythrocytes.	Nitrogen	142-143	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
10873157-5	2000	Expression of IL-6 and IL-8 was sensitive to SB203580, the specific inhibitor of p38 mitogen-activated protein (MAP) kinase and PD98059, an inhibitor of MAP kinase kinase.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	128-135	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
10893219-4	2000	Maximal IL-8 release was achieved with 10 ng/ml of TGF-beta1 after 16 h of incubation, which was inhibited by the transcription inhibitor actinomycin D and the corticosteroid dexamethasone but was not affected by the nonselective COX inhibitor indomethacin and the selective COX-2 inhibitor NS-398 despite their inhibition on TGF-beta1-induced PGE(2) release.	Dexamethasone	175-188	C-X-C motif chemokine ligand 8	Homo sapiens	8-12
10893219-4	2000	Maximal IL-8 release was achieved with 10 ng/ml of TGF-beta1 after 16 h of incubation, which was inhibited by the transcription inhibitor actinomycin D and the corticosteroid dexamethasone but was not affected by the nonselective COX inhibitor indomethacin and the selective COX-2 inhibitor NS-398 despite their inhibition on TGF-beta1-induced PGE(2) release.	Indomethacin	244-256	C-X-C motif chemokine ligand 8	Homo sapiens	8-12
10893219-4	2000	Maximal IL-8 release was achieved with 10 ng/ml of TGF-beta1 after 16 h of incubation, which was inhibited by the transcription inhibitor actinomycin D and the corticosteroid dexamethasone but was not affected by the nonselective COX inhibitor indomethacin and the selective COX-2 inhibitor NS-398 despite their inhibition on TGF-beta1-induced PGE(2) release.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	291-297	C-X-C motif chemokine ligand 8	Homo sapiens	8-12
10893219-4	2000	Maximal IL-8 release was achieved with 10 ng/ml of TGF-beta1 after 16 h of incubation, which was inhibited by the transcription inhibitor actinomycin D and the corticosteroid dexamethasone but was not affected by the nonselective COX inhibitor indomethacin and the selective COX-2 inhibitor NS-398 despite their inhibition on TGF-beta1-induced PGE(2) release.	Prostaglandins E	344-347	C-X-C motif chemokine ligand 8	Homo sapiens	8-12
10873156-2	2000	Here, we tested the effects of the beta(2)-agonists salbutamol (Salbu) and salmeterol (Salme) on IL-8 release and tumor necrosis factor (TNF)-alpha-induced IL-8 release from ASM cells.	Albuterol	52-62	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
10873156-2	2000	Here, we tested the effects of the beta(2)-agonists salbutamol (Salbu) and salmeterol (Salme) on IL-8 release and tumor necrosis factor (TNF)-alpha-induced IL-8 release from ASM cells.	Albuterol	64-69	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
10873156-2	2000	Here, we tested the effects of the beta(2)-agonists salbutamol (Salbu) and salmeterol (Salme) on IL-8 release and tumor necrosis factor (TNF)-alpha-induced IL-8 release from ASM cells.	Salmeterol Xinafoate	75-85	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
10873156-2	2000	Here, we tested the effects of the beta(2)-agonists salbutamol (Salbu) and salmeterol (Salme) on IL-8 release and tumor necrosis factor (TNF)-alpha-induced IL-8 release from ASM cells.	Salmeterol Xinafoate	87-92	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
10873156-4	2000	TNF-alpha (10 ng/ml)-induced IL-8 release was markedly inhibited by the steroids dexamethasone (Dex) (0.1 to 10 microM) and fluticasone (Flut) (0.01 to 1 microM) but unaffected by Salbu, Salme, FSK, or 8-Br-cAMP.	Steroids	72-80	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
10873156-4	2000	TNF-alpha (10 ng/ml)-induced IL-8 release was markedly inhibited by the steroids dexamethasone (Dex) (0.1 to 10 microM) and fluticasone (Flut) (0.01 to 1 microM) but unaffected by Salbu, Salme, FSK, or 8-Br-cAMP.	Dexamethasone	81-94	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
10873156-4	2000	TNF-alpha (10 ng/ml)-induced IL-8 release was markedly inhibited by the steroids dexamethasone (Dex) (0.1 to 10 microM) and fluticasone (Flut) (0.01 to 1 microM) but unaffected by Salbu, Salme, FSK, or 8-Br-cAMP.	Dexamethasone	96-99	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
10921707-6	2000	RESULTS: In the pilot study, heparin-bonded circuit patients had less complement 3a (p &lt; 0.001) and interleukin-8 (p &lt; 0.05) compared with uncoated cardiopulmonary bypass circuit patients.	Heparin	29-36	C-X-C motif chemokine ligand 8	Homo sapiens	103-116
10873156-4	2000	TNF-alpha (10 ng/ml)-induced IL-8 release was markedly inhibited by the steroids dexamethasone (Dex) (0.1 to 10 microM) and fluticasone (Flut) (0.01 to 1 microM) but unaffected by Salbu, Salme, FSK, or 8-Br-cAMP.	Fluticasone	124-135	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
10873156-4	2000	TNF-alpha (10 ng/ml)-induced IL-8 release was markedly inhibited by the steroids dexamethasone (Dex) (0.1 to 10 microM) and fluticasone (Flut) (0.01 to 1 microM) but unaffected by Salbu, Salme, FSK, or 8-Br-cAMP.	Fluticasone	137-141	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
10873156-4	2000	TNF-alpha (10 ng/ml)-induced IL-8 release was markedly inhibited by the steroids dexamethasone (Dex) (0.1 to 10 microM) and fluticasone (Flut) (0.01 to 1 microM) but unaffected by Salbu, Salme, FSK, or 8-Br-cAMP.	Albuterol	180-185	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
10873156-4	2000	TNF-alpha (10 ng/ml)-induced IL-8 release was markedly inhibited by the steroids dexamethasone (Dex) (0.1 to 10 microM) and fluticasone (Flut) (0.01 to 1 microM) but unaffected by Salbu, Salme, FSK, or 8-Br-cAMP.	Salmeterol Xinafoate	187-192	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
10873156-4	2000	TNF-alpha (10 ng/ml)-induced IL-8 release was markedly inhibited by the steroids dexamethasone (Dex) (0.1 to 10 microM) and fluticasone (Flut) (0.01 to 1 microM) but unaffected by Salbu, Salme, FSK, or 8-Br-cAMP.	Colforsin	194-197	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
10873156-4	2000	TNF-alpha (10 ng/ml)-induced IL-8 release was markedly inhibited by the steroids dexamethasone (Dex) (0.1 to 10 microM) and fluticasone (Flut) (0.01 to 1 microM) but unaffected by Salbu, Salme, FSK, or 8-Br-cAMP.	8-Bromo Cyclic Adenosine Monophosphate	202-211	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
10873157-5	2000	Expression of IL-6 and IL-8 was sensitive to SB203580, the specific inhibitor of p38 mitogen-activated protein (MAP) kinase and PD98059, an inhibitor of MAP kinase kinase.	SB 203580	45-53	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
10953284-5	2000	Pretreatment of poorly and highly metastatic human HT-29 colon carcinoma cells with the broad-range inhibitors sodium fluoride (NaF) and sodium pyrophosphate (PyroP) resulted in strong reduction in adhesion of HT-29 cells to various ECM components.	Sodium Fluoride	111-126	C-X-C motif chemokine ligand 8	Homo sapiens	128-131
10953284-8	2000	Therefore, the effects of NaF on adhesion-mediated Tyr phosphorylation were investigated further.	Tyrosine	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
11357999-4	2000	Both the replication of DV and the production of IL-6 and IL-8 by HUVEC after DV infection were inhibited by ribavirin, an antiviral synthetic guanosine analogue.	Ribavirin	109-118	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
11357999-4	2000	Both the replication of DV and the production of IL-6 and IL-8 by HUVEC after DV infection were inhibited by ribavirin, an antiviral synthetic guanosine analogue.	Guanosine	143-152	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
10861141-9	2000	However, expression of TNF-alpha and IL-8, IFN-gamma, and IL-6 and IL-1beta was 2-20 times greater in patients administered 100% than in those administered 30% oxygen.	Oxygen	160-166	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
10921541-13	2000	CONCLUSIONS: PGE1 suppressed the production of IL-6 and IL-8 but not IL-10, IL-1ra, sTNF RI, or sTNF RII.	Alprostadil	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
10808107-9	2000	RESULTS: MEEs from children with chronic mucous otitis media contained significantly higher mean concentrations of IL-8 559.4 pg/mg total protein (TP) (+/-535.6) in comparison with normal serum 17.79 pg/mg TP (+/-10.9), serous OM 40.3 pg/mg TP (+/-28.1) and purulent OM 104.4 pg/mg TP (+/-128.6).	tp	147-149	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
10808107-9	2000	RESULTS: MEEs from children with chronic mucous otitis media contained significantly higher mean concentrations of IL-8 559.4 pg/mg total protein (TP) (+/-535.6) in comparison with normal serum 17.79 pg/mg TP (+/-10.9), serous OM 40.3 pg/mg TP (+/-28.1) and purulent OM 104.4 pg/mg TP (+/-128.6).	tp	206-208	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
11225832-4	2000	The tolerance limits of electrolytes, NaCl, NaF, NaI, NaNO3, Na2SO4 and of cations, Mg2+ and Ca2+ in the sorption of the six metal ions are reported.	Metals	125-130	C-X-C motif chemokine ligand 8	Homo sapiens	44-47
10926336-0	2000	Erythromycin inhibits beta2-integrins (CD11b/CD18) expression, interleukin-8 release and intracellular oxidative metabolism in neutrophils.	Erythromycin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
10882695-2	2000	Grepafloxacin 1-30 mg/L inhibited the production of interleukin 1alpha (IL-1alpha) and IL-1beta, and the expression of IL-1alpha, IL-1beta, tumour necrosis factor alpha (TNFalpha), IL-6 and IL-8 mRNA.	grepafloxacin	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
10884648-10	2000	In contrast, nitroglycerin infusion significantly increased C3a in patients without diabetes and increased elastase and interleukin 8 levels in patients with diabetes.	Nitroglycerin	13-26	C-X-C motif chemokine ligand 8	Homo sapiens	120-133
10864914-6	2000	Treatment of the TC/EC coculture media with anti-TNF-alpha or anti-IL-8 antibodies reduced the media-induced neutrophil adhesion response.	Technetium	17-19	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
10875492-2	2000	Interleukin-8 in the sputa from GD-induced asthmatic patients increased significantly after the exposure to GD.	Gadolinium	32-34	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
10875492-2	2000	Interleukin-8 in the sputa from GD-induced asthmatic patients increased significantly after the exposure to GD.	Gadolinium	108-110	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
10875492-3	2000	OBJECTIVE: To confirm IL-8 production from bronchial epithelial cells when exposed to GD, and to evaluate the role of IL-8 on neutrophil recruitment.	Gadolinium	86-88	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
10875492-9	2000	RESULTS: Interleukin-8 production and neutrophil chemotactic activity from bronchial epithelial cells significantly increased with additions of GD in a dose-dependent manner (P &lt; .05, respectively), and were significantly augmented with additions of PBMC supernatant (P &lt; .05, respectively) at each concentration.	Gadolinium	144-146	C-X-C motif chemokine ligand 8	Homo sapiens	9-22
10875492-12	2000	CONCLUSION: These results suggest that IL-8 produced from bronchial epithelial cells may be a major cytokine, which induces neutrophil migration into the airways when exposed to GD.	Gadolinium	178-180	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
10917872-1	2000	Does inhibition of the mevalonate pathway lower interleukin-8 levels in the vessel wall?	Mevalonic Acid	23-33	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
10864914-6	2000	Treatment of the TC/EC coculture media with anti-TNF-alpha or anti-IL-8 antibodies reduced the media-induced neutrophil adhesion response.	ec	20-22	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
10862535-3	2000	The aim of this study was to determine whether the increased histamine release in highly trained athletes is related to a high plasma level in interleukin-1 beta (IL-1beta), IL-3, or IL-8 in arterial blood.	Histamine	61-70	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
11108572-5	2000	Among OA patients in whom remarkable improvement was noted in hydrarthrosis, the synovial fluid IL-6 and IL-8 levels at the initial examination were relatively higher, and were markedly decreased after treatment with sodium hyaluronate (NaHA).	Hyaluronic Acid	217-235	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
11108572-5	2000	Among OA patients in whom remarkable improvement was noted in hydrarthrosis, the synovial fluid IL-6 and IL-8 levels at the initial examination were relatively higher, and were markedly decreased after treatment with sodium hyaluronate (NaHA).	naha	237-241	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
11108572-6	2000	Among those in whom no improvement was noted in hydrarthrosis, the synovial fluid IL-6 and IL-8 levels at the time of initial examination were relatively lower, and hydrarthrosis was not significantly improved even after treatment with NaHA.	naha	236-240	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
10837166-4	2000	Treatment of cells with diphenylene iodonium inhibited virus-induced oxidative stress and IL-8 elaboration, but allopurinol, ibuprofen, and rotenone had no effect.	diphenyleneiodonium	24-44	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
10875461-10	2000	Oxygen-derived free radicals and many cytokines (e.g., interleukin [IL]-1, IL-6, IL-8, tumor necrosis factor-alpha, platelet activating factor) are considered to be principal mediators in the transformation of acute pancreatitis from a local inflammatory process into a multiorgan illness.	Oxygen	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
10957762-8	2000	In cultured respiratory epithelial cells, calcium oxalate increases the release of two interleukins (IL), IL-8 and IL-6, involved in granuloma formation by 8 to 10 fold within 24 hours.	Calcium Oxalate	42-57	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
10938902-5	2000	S1P displayed a dual effect on sodium fluoride (NaF)-induced platelet aggregation and had no effect on the aggregation induced by ADP or lysophosphatidic acid (LPA).	Sodium Fluoride	31-46	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
10894110-10	2000	Both N-acetylcysteine and pyrrolidine dithiocarbamate attenuated the action of DEP on IL-8 mRNA expression, suggesting that oxidant-mediated pathway might be involved in its processes.	Acetylcysteine	5-21	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
10894110-10	2000	Both N-acetylcysteine and pyrrolidine dithiocarbamate attenuated the action of DEP on IL-8 mRNA expression, suggesting that oxidant-mediated pathway might be involved in its processes.	pyrrolidine dithiocarbamic acid	26-53	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
10828966-14	2000	Furthermore, the stimulations exerted by GTPgammaS, isoproterenol, FSK, and NaF on adenylyl cyclase were also augmented in cells treated with C-ANP(4-23).	c-anp	142-147	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
10807767-3	2000	Using human umbilical vein endothelial cells (HUVECs), we analyzed the role of small GTP-binding Rho proteins and p38 mitogen-activated protein kinase (MAPK) for LPS-dependent IL-8 expression in endothelial cells.	Guanosine Triphosphate	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
18967950-7	2000	The effect of NaF, NaCl, NaNO(3), Na(2)SO(4), and Na(3)PO(4) on the sorption of these metal ions has been investigated.	Metals	86-91	C-X-C motif chemokine ligand 8	Homo sapiens	14-17
10775461-2	2000	Here, we investigated whether arsenic, which has been shown to inhibit the ubiquitin-proteasome pathway, could inhibit TNF-alpha-mediated increases in IL-8 expression.	Arsenic	30-37	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
10887619-0	2000	Macrolide treatment decreased the size of nasal polyps and IL-8 levels in nasal lavage.	Macrolides	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
10887619-3	2000	Lancet 351:420, 1998), and that macrolides can directly reduce the production of IL-8 by nasal epithelial cells (Suzuki H, Shimomura A, Ikeda K, et al.	Macrolides	32-42	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
10887619-7	2000	The IL-8 levels in nasal lavage from patients with nasal polyps were reduced during macrolide treatment.	Macrolides	84-93	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
10887619-9	2000	In the group whose polyps were reduced in size, the IL-8 levels dramatically decreased from 231.2 pg/mL to 44.0 pg/mL (p &lt; 0.05), and were significantly higher before macrolide treatment than those in the group whose polyps showed no change (p &lt; 0.005).	Macrolides	170-179	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
10887619-10	2000	This reduction in IL-8 may be an important aspect of the effect of macrolide treatment on nasal polyps in chronic rhinosinusitis.	Macrolides	67-76	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
10770757-3	2000	In this study, AG7088 was tested for its antiviral activity and ability to inhibit the production of IL-6 and IL-8 in a human bronchial epithelial cell line, BEAS-2B.	rupintrivir	15-21	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
10770757-5	2000	Treatment of HRV 14-infected cells with AG7088 resulted in a statistically significant (P, &lt;0.05) dose-dependent reduction in the levels of infectious virus as well as IL-6 and IL-8 released into the cell supernatant compared to the results obtained for compound-free infected cells.	rupintrivir	40-46	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
10817569-0	2000	Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells.	Uric Acid	270-298	C-X-C motif chemokine ligand 8	Homo sapiens	231-244
10770757-7	2000	In time-of-addition studies, AG7088 could be added as late as 14 to 26 h after HRV 14 infection of BEAS-2B cells and still result in a statistically significant (P, &lt;0.05) reduction in the levels of infectious virus, IL-6, and IL-8 compared to the results obtained for compound-free infected cells.	rupintrivir	29-35	C-X-C motif chemokine ligand 8	Homo sapiens	230-234
10775461-6	2000	Exposing the cells to 500 microM arsenite, prior to adding TNF-alpha, completely inhibited IkappaBalpha degradation, NF-kappaB translocation, NF-kappaB-dependent gene transcription, and transcription of the endogenous gene for IL-8.	arsenite	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	227-231
10817569-0	2000	Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells.	Calcium Pyrophosphate	303-324	C-X-C motif chemokine ligand 8	Homo sapiens	231-244
10823417-4	2000	In this report, we demonstrate that a subset of human lung carcinoma cell lines respond to paclitaxel treatment with an up to a fivefold increase in the production of interleukin-8 (IL-8).	Paclitaxel	91-101	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
10823417-0	2000	Paclitaxel up-regulates interleukin-8 synthesis in human lung carcinoma through an NF-kappaB- and AP-1-dependent mechanism.	Paclitaxel	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	24-37
10823417-6	2000	Increased IL-8 mRNA is seen as early as 45 min with a peak at 4 h after paclitaxel treatment.	Paclitaxel	72-82	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
10823417-4	2000	In this report, we demonstrate that a subset of human lung carcinoma cell lines respond to paclitaxel treatment with an up to a fivefold increase in the production of interleukin-8 (IL-8).	Paclitaxel	91-101	C-X-C motif chemokine ligand 8	Homo sapiens	167-180
10773004-7	2000	The results showed that LPS induced p38 MAP kinase phosphorylation and activity, and SB 203580 as a selective inhibitor of p38 MAP kinase activity inhibited p38 MAP kinase activity and IL-8 expression in LPS-stimulated pulmonary vascular endothelial cells.	SB 203580	85-94	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
11515628-6	2000	RESULTS: Incubation of neutrophils with 10(-6) to 10(4) M troxipide caused inhibition of recombinant interleukin-8-induced migration.	troxipide	58-67	C-X-C motif chemokine ligand 8	Homo sapiens	101-114
10843593-0	2000	Polyoxygenated dysidea sterols that inhibit the binding of [I125] IL-8 to the human recombinant IL-8 receptor type A.	Sterols	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
10815919-11	2000	Similarly after 11 days treatment, production of vascular endothelial growth factor and interleukin 8 was significantly lower in C225 and C225 plus gemcitabine-treated tumors versus gemcitabine-treated and control tumors.	gemcitabine	148-159	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
10815919-11	2000	Similarly after 11 days treatment, production of vascular endothelial growth factor and interleukin 8 was significantly lower in C225 and C225 plus gemcitabine-treated tumors versus gemcitabine-treated and control tumors.	gemcitabine	182-193	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
10853849-2	2000	Recent research shows that macrolide antibiotics may reduce interleukin (IL)-8 production by bronchial epithelial cells and inhibit neutrophil chemotaxis.	macrolide antibiotics	27-48	C-X-C motif chemokine ligand 8	Homo sapiens	60-78
10853849-6	2000	There were significant (p&lt;0.05) pre- to post-exposure increases in total cells, neutrophils, IL-6 and IL-8 in both the azithromycin and placebo arms.	Azithromycin	122-134	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
10843593-0	2000	Polyoxygenated dysidea sterols that inhibit the binding of [I125] IL-8 to the human recombinant IL-8 receptor type A.	Sterols	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
10833370-9	2000	Levels of IL-8 mRNA and protein were also dose-dependently increased by stimulation with IL-1beta, TNF-alpha and TPA.	Tetradecanoylphorbol Acetate	113-116	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
10843593-1	2000	The combined CH(2)Cl(2) and MeOH crude extract of a new species of the marine sponge Dysidea, collected in Northern Australia was found to inhibit the binding of [I125] interleukin-8 [IL-8] to the human recombinant IL-8 receptor type A at 500 microg/mL.	(2)cl	15-20	C-X-C motif chemokine ligand 8	Homo sapiens	169-182
10843593-1	2000	The combined CH(2)Cl(2) and MeOH crude extract of a new species of the marine sponge Dysidea, collected in Northern Australia was found to inhibit the binding of [I125] interleukin-8 [IL-8] to the human recombinant IL-8 receptor type A at 500 microg/mL.	(2)cl	15-20	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
10843593-1	2000	The combined CH(2)Cl(2) and MeOH crude extract of a new species of the marine sponge Dysidea, collected in Northern Australia was found to inhibit the binding of [I125] interleukin-8 [IL-8] to the human recombinant IL-8 receptor type A at 500 microg/mL.	(2)cl	15-20	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
10843593-1	2000	The combined CH(2)Cl(2) and MeOH crude extract of a new species of the marine sponge Dysidea, collected in Northern Australia was found to inhibit the binding of [I125] interleukin-8 [IL-8] to the human recombinant IL-8 receptor type A at 500 microg/mL.	Methanol	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	169-182
10843593-1	2000	The combined CH(2)Cl(2) and MeOH crude extract of a new species of the marine sponge Dysidea, collected in Northern Australia was found to inhibit the binding of [I125] interleukin-8 [IL-8] to the human recombinant IL-8 receptor type A at 500 microg/mL.	Methanol	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
10843593-1	2000	The combined CH(2)Cl(2) and MeOH crude extract of a new species of the marine sponge Dysidea, collected in Northern Australia was found to inhibit the binding of [I125] interleukin-8 [IL-8] to the human recombinant IL-8 receptor type A at 500 microg/mL.	Methanol	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
10921280-6	2000	Acute exposure to cigarette smoke initiates a superoxide-dependent mechanism that, through NF-kappa B activation and IL-8 expression, induces infiltration of neutrophils into the airways in vivo.	Superoxides	46-56	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
11778222-7	2000	After dexamethasone treatment, the expression of NF-kappa B activation and IL-8 mRNA became lower.	Dexamethasone	6-19	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
10868450-7	2000	In patients with DU the duodenal mucosal tissues with GM (MB-unstained mucosa) showed significantly higher levels of IL-8 than those without GM (MB-stained mucosa) or the antral mucosa.	gm	54-56	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
10868450-10	2000	CONCLUSIONS: Increased IL-8 activity in the duodenal mucosa with GM may be important for ulcerogenesis in H. pylori-positive DU patients.	gm	65-67	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
10886812-7	2000	The concurrent application of indomethacin at 10 microg/ml reversed this interleukin-8 induced inhibition.	Indomethacin	30-42	C-X-C motif chemokine ligand 8	Homo sapiens	73-86
10784148-5	2000	NaF gave the best recovery, 104%, for BA relative to the 88% obtained by batch processing.	Benzoic Acid	38-40	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
10766857-3	2000	We report that IL-8 mRNA accumulation and protein secretion were down-regulated in IL-1beta- and lipopolysaccharide-stimulated differentiated HT-29 cells (HT-29/MTX, where MTX is methotrexate) compared with undifferentiated cells (HT-29/p), whereas no differential effects were found following tumor necrosis factor (TNF)-alpha or phorbol myristate acetate stimulation.	Methotrexate	161-164	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
10766857-3	2000	We report that IL-8 mRNA accumulation and protein secretion were down-regulated in IL-1beta- and lipopolysaccharide-stimulated differentiated HT-29 cells (HT-29/MTX, where MTX is methotrexate) compared with undifferentiated cells (HT-29/p), whereas no differential effects were found following tumor necrosis factor (TNF)-alpha or phorbol myristate acetate stimulation.	Methotrexate	172-175	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
10766857-3	2000	We report that IL-8 mRNA accumulation and protein secretion were down-regulated in IL-1beta- and lipopolysaccharide-stimulated differentiated HT-29 cells (HT-29/MTX, where MTX is methotrexate) compared with undifferentiated cells (HT-29/p), whereas no differential effects were found following tumor necrosis factor (TNF)-alpha or phorbol myristate acetate stimulation.	Methotrexate	179-191	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
10766857-3	2000	We report that IL-8 mRNA accumulation and protein secretion were down-regulated in IL-1beta- and lipopolysaccharide-stimulated differentiated HT-29 cells (HT-29/MTX, where MTX is methotrexate) compared with undifferentiated cells (HT-29/p), whereas no differential effects were found following tumor necrosis factor (TNF)-alpha or phorbol myristate acetate stimulation.	Tetradecanoylphorbol Acetate	331-356	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
10769273-12	2000	Coincubation with cerivastatin resulted in significantly lower MCP-1 and IL-8 production, whereas the release of TNF-alpha remained unaffected.	cerivastatin	18-30	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
10754327-13	2000	LY294002 blocked IL-8-dependent Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
10754327-14	2000	PD98059 and LY294002 significantly attenuated IL-8 delay of apoptosis.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
10754327-14	2000	PD98059 and LY294002 significantly attenuated IL-8 delay of apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
10722601-8	2000	The release of interleukin-8 was markedly suppressed by the p38 mitogen-activated protein kinase inhibitor SB203580 but was only minimally suppressed by the mitogen-activated protein/extracellular signal-regulated kinase inhibitor PD98059.	SB 203580	107-115	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
10753876-0	2000	Reactive nitrogen and oxygen species attenuate interleukin- 8-induced neutrophil chemotactic activity in vitro.	reactive nitrogen and oxygen species	0-36	C-X-C motif chemokine ligand 8	Homo sapiens	47-61
10753876-3	2000	To test this hypothesis, the neutrophil chemotactic activity (NCA) of interleukin-8 (IL-8) incubated with peroxynitrite was evaluated.	Peroxynitrous Acid	106-119	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
10753876-3	2000	To test this hypothesis, the neutrophil chemotactic activity (NCA) of interleukin-8 (IL-8) incubated with peroxynitrite was evaluated.	Peroxynitrous Acid	106-119	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
10753876-4	2000	Peroxynitrite attenuated IL-8 NCA in a dose-dependent manner (p &lt; 0.01) but did not significantly reduce NCA induced by leukotriene B(4) or complement-activated serum.	Peroxynitrous Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
10753876-6	2000	Papa-NONOate [N-(3-ammoniopropyl)-N-(n-propyl)amino]diazen-1-ium-1, 2-dialase or sodium nitroprusside, NO donors, or a combination of xanthine and xanthine oxidase to generate superoxide did not show an inhibitory effect on NCA induced by IL-8.	PAPA NONOate	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	239-243
10753876-6	2000	Papa-NONOate [N-(3-ammoniopropyl)-N-(n-propyl)amino]diazen-1-ium-1, 2-dialase or sodium nitroprusside, NO donors, or a combination of xanthine and xanthine oxidase to generate superoxide did not show an inhibitory effect on NCA induced by IL-8.	-ium	60-64	C-X-C motif chemokine ligand 8	Homo sapiens	239-243
10753876-7	2000	In contrast, small amounts of SIN-1, a peroxynitrite generator, caused a concentration-dependent inhibition of NCA by IL-8.	Peroxynitrous Acid	39-52	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
10753876-8	2000	Consistent with its capacity to reduce NCA, peroxynitrite treatment reduced IL-8 binding to neutrophils.	Peroxynitrous Acid	44-57	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
10798763-6	2000	FK506 and MMF were also able to upregulate IL-8, although the effect was less dramatic than observed for CsA.	Tacrolimus	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
10798763-7	2000	Low concentrations of prednisolone (0.01 and 0.001 microg/ml) enhanced IL-6 and IL-8 secretion, whereas concentrations &gt; or =0.01 microg/ml significantly diminished IL-6 secretion.	Prednisolone	22-34	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
10807428-6	2000	In vitro sofalcone has a significant bacteriocidal effect against H. pylori and can also significantly prevent adherence of this bacterium to MKN45 cells, thus remarkably reducing IL-8 production of these cells in response to stimulation by H. pylori.	sofalcone	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
10809292-0	2000	Perfluorocarbon blocks tumor necrosis factor-alpha-induced interleukin-8 release from alveolar epithelial cells in vitro.	Fluorocarbons	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	59-72
10809292-1	2000	OBJECTIVE: To determine whether tumor necrosis factor (TNF)-alpha-induced interleukin (IL)-8 production by pulmonary alveolar epithelial cells is blocked by perfluorocarbon (PFC).	Fluorocarbons	157-172	C-X-C motif chemokine ligand 8	Homo sapiens	74-92
10772385-9	2000	At the mRNA level, inhibition was only seen with KU812 cells and IL-8 in the presence of azelastine at 10-(10) M. These data show thus distinct inhibitory patterns for different antihistamines during cytokine production from human mast cells and basophils which may contribute to the anti-inflammatory effects of these drugs during treatment of allergic diseases.	azelastine	89-99	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
10753876-9	2000	Nitrotyrosine was detected in the IL-8 incubated with peroxynitrite by enzyme-linked immunosorbent assay.	3-nitrotyrosine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
10753876-9	2000	Nitrotyrosine was detected in the IL-8 incubated with peroxynitrite by enzyme-linked immunosorbent assay.	Peroxynitrous Acid	54-67	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
10753876-10	2000	These findings are consistent with nitration of tyrosine by peroxynitrite with subsequent inhibition of IL-8 binding to neutrophils and a reduction in NCA and suggest that oxidants may play an important role in regulation of IL-8-induced neutrophil chemotaxis.	Tyrosine	48-56	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
10753876-10	2000	These findings are consistent with nitration of tyrosine by peroxynitrite with subsequent inhibition of IL-8 binding to neutrophils and a reduction in NCA and suggest that oxidants may play an important role in regulation of IL-8-induced neutrophil chemotaxis.	Tyrosine	48-56	C-X-C motif chemokine ligand 8	Homo sapiens	225-229
10753876-10	2000	These findings are consistent with nitration of tyrosine by peroxynitrite with subsequent inhibition of IL-8 binding to neutrophils and a reduction in NCA and suggest that oxidants may play an important role in regulation of IL-8-induced neutrophil chemotaxis.	Peroxynitrous Acid	60-73	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
10753876-10	2000	These findings are consistent with nitration of tyrosine by peroxynitrite with subsequent inhibition of IL-8 binding to neutrophils and a reduction in NCA and suggest that oxidants may play an important role in regulation of IL-8-induced neutrophil chemotaxis.	Peroxynitrous Acid	60-73	C-X-C motif chemokine ligand 8	Homo sapiens	225-229
10745031-0	2000	A novel mechanism of retinoic acid-enhanced interleukin-8 gene expression in airway epithelium.	Tretinoin	21-34	C-X-C motif chemokine ligand 8	Homo sapiens	44-57
10745031-1	2000	A 3- to 8-fold stimulation of interleukin (IL)-8 gene expression by all-trans-retinoic acid (ATRA) was demonstrated in primary cultures of human and monkey tracheobronchial epithelial cells and BEAS-2B serum-sensitive cell line.	Tretinoin	71-91	C-X-C motif chemokine ligand 8	Homo sapiens	30-48
10745031-1	2000	A 3- to 8-fold stimulation of interleukin (IL)-8 gene expression by all-trans-retinoic acid (ATRA) was demonstrated in primary cultures of human and monkey tracheobronchial epithelial cells and BEAS-2B serum-sensitive cell line.	Tretinoin	93-97	C-X-C motif chemokine ligand 8	Homo sapiens	30-48
10745031-2	2000	The effect of ATRA on IL-8 gene expression is dose- and time-dependent.	Tretinoin	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
10745031-5	2000	A difference in nuclear run-on activity suggests that a transcriptional mechanism is involved in ATRA-enhanced IL-8 gene expression.	Tretinoin	97-101	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
10745031-13	2000	Taking these data together, a novel mechanism is proposed in which ATRA activates promoter activity of IL-8 gene through TRX-dependent NF-kappaB activation.	Tretinoin	67-71	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
10805216-5	2000	IFN-gamma as well as the GCs, Dexamethasone and Budesonide, inhibited TNF-alpha induced IL-8 secretion in a dose-dependent manner.	Dexamethasone	30-43	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
10805216-5	2000	IFN-gamma as well as the GCs, Dexamethasone and Budesonide, inhibited TNF-alpha induced IL-8 secretion in a dose-dependent manner.	Budesonide	48-58	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
10744650-7	2000	Cap formation and superoxide anion production induced by solid-phase P-selectin or by IL-8 and soluble rP-selectin treatment were inhibited by treatment of the leukocytes with cytochalasin B.	Superoxides	18-34	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
10722601-8	2000	The release of interleukin-8 was markedly suppressed by the p38 mitogen-activated protein kinase inhibitor SB203580 but was only minimally suppressed by the mitogen-activated protein/extracellular signal-regulated kinase inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	231-238	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
10805370-8	2000	The enhancement of IL-6 and IL-8 production by MCG was abrogated when MCG were pretreated with the serine protease inhibitor phenylmethylsulfonyl fluoride (PMSF).	Phenylmethylsulfonyl Fluoride	125-154	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
10760560-5	2000	RESULTS: Moclobemide 10(-3) and 10(-5) M significantly suppressed the unstimulated production of TNFalpha and IL-8, and significantly enhanced the stimulated-production of IL-10.	Moclobemide	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
10760560-7	2000	CONCLUSIONS: Moclobemide has negative immunoregulatory capacities through inhibition of the production of proinflammatory cytokines, i.e. TNFalpha and IL-8, and through enhancement of the production of IL-10, an anti-inflammatory cytokine.	Moclobemide	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
10782906-11	2000	During steroid therapy, plasma levels of the pro-inflammatory cytokine IL-8 fell as early as day 14, while levels of the anti-inflammatory cytokine IL-10 increased on day 21.	Steroids	7-14	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
10725748-7	2000	In the same cells, IL-8 also caused superoxide release.	Superoxides	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
10805370-8	2000	The enhancement of IL-6 and IL-8 production by MCG was abrogated when MCG were pretreated with the serine protease inhibitor phenylmethylsulfonyl fluoride (PMSF).	Phenylmethylsulfonyl Fluoride	156-160	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
10677576-0	2000	Attenuation of interleukin-8 production by inhibiting nuclear factor-kappaB translocation using decoy oligonucleotides.	Oligonucleotides	102-118	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
10865191-3	2000	Arabinosylated lipoarabinomannan (ARA-LAM) stimulated hyporesponsiveness by reducing TNF-alpha, GM-CSF, G-CSF, IL-10, and IL-6 release similarly to LPS, but caused no changes in IL-8 secretion.	lipoarabinomannan	15-32	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
10865191-3	2000	Arabinosylated lipoarabinomannan (ARA-LAM) stimulated hyporesponsiveness by reducing TNF-alpha, GM-CSF, G-CSF, IL-10, and IL-6 release similarly to LPS, but caused no changes in IL-8 secretion.	ara-lam	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
10775070-1	2000	We have previously shown that the in vivo infusion of interleukin-8 (IL8) in rats causes albuminuria and an increased catabolism of the heparan sulfate (HS) glycosaminoglycans (GAG).	Heparitin Sulfate	136-151	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
10775070-1	2000	We have previously shown that the in vivo infusion of interleukin-8 (IL8) in rats causes albuminuria and an increased catabolism of the heparan sulfate (HS) glycosaminoglycans (GAG).	hs) glycosaminoglycans	153-175	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
10775070-1	2000	We have previously shown that the in vivo infusion of interleukin-8 (IL8) in rats causes albuminuria and an increased catabolism of the heparan sulfate (HS) glycosaminoglycans (GAG).	Glycosaminoglycans	177-180	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
10775070-6	2000	The HSGAG 35sulfate uptake was higher in IL8-treated rats than controls (387+/-138 vs. 246+/-15 cpm/1,000 glomeruli, mean +/- SD, P&lt;0.05).	35sulfate	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
10722953-0	2000	Modulating pharmacokinetics of an anti-interleukin-8 F(ab")(2) by amine-specific PEGylation with preserved bioactivity.	Amines	66-71	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
10677576-5	2000	In the current study, we produced phosphorothioate-modified oligonucleotides containing the specific DNA sequence that NF-kappaB binds within the IL-8 gene.	Parathion	34-50	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
10677576-5	2000	In the current study, we produced phosphorothioate-modified oligonucleotides containing the specific DNA sequence that NF-kappaB binds within the IL-8 gene.	Oligonucleotides	60-76	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
10677576-7	2000	We found that transfection with these oligonucleotides significantly inhibited monocyte IL-8 production.	Oligonucleotides	38-54	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
10677576-9	2000	This single-stranded oligonucleotide also inhibited IL-1beta-induced translocation of NF-kappaB to the nucleus and reduced IL-8 mRNA expression.	Oligonucleotides	21-36	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
10677576-10	2000	These studies demonstrated that monocyte production of IL-8 can be attenuated using a single-stranded oligonucleotide that binds a transcriptional activating protein before it translocates to the cell nucleus.	single-stranded oligonucleotide	86-117	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
10706733-4	2000	Exposure of non-CF gland cells to hypotonic (85 mM) NaCl solution, compared with isotonic (115 mM) NaCl and hypertonic (170 mM) NaCl solutions, resulted in a significant decrease in IL-8 production that was paralleled by a strong inhibition of activated NF-kappa B associated with an increased cytosolic expression of I kappa B alpha and a decrease in the I kappa B kinase alpha protein level.	Sodium Chloride	52-56	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
10706733-7	2000	This is the first demonstration that primary human CF bronchial gland cells exhibit abnormally high IL-8 production through constitutively activated NF-kappa B and high I kappa B kinase alpha level, whatever the hypo-, iso-, and hypertonic NaCl milieu.	Sodium Chloride	240-244	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
10706733-0	2000	High susceptibility for cystic fibrosis human airway gland cells to produce IL-8 through the I kappa B kinase alpha pathway in response to extracellular NaCl content.	Sodium Chloride	153-157	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
10702246-6	2000	Treatment of SK-OV-3 cells with the inhibitors genestein and herbimycin A indicated that tyrosine kinases were involved in the IL-8 activation of Erk1 and Erk2.	herbimycin	61-73	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
10706733-4	2000	Exposure of non-CF gland cells to hypotonic (85 mM) NaCl solution, compared with isotonic (115 mM) NaCl and hypertonic (170 mM) NaCl solutions, resulted in a significant decrease in IL-8 production that was paralleled by a strong inhibition of activated NF-kappa B associated with an increased cytosolic expression of I kappa B alpha and a decrease in the I kappa B kinase alpha protein level.	nacl solution	52-65	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
10755555-0	2000	Association of glucocorticoids and cyclosporin A or rapamycin prevents E-selectin and IL-8 expression during LPS- and TNFalpha-mediated endothelial cell activation.	Cyclosporine	35-48	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
10755555-0	2000	Association of glucocorticoids and cyclosporin A or rapamycin prevents E-selectin and IL-8 expression during LPS- and TNFalpha-mediated endothelial cell activation.	Sirolimus	52-61	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	Sesquiterpenes	126-139	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
10696066-7	2000	Antioxidants, pyrrolidine dithiocarbamate, and N-acetyl-L-cysteine significantly inhibited IL-8 mRNA and protein levels by BET-1A cells.	pyrrolidine dithiocarbamic acid	14-41	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
10696066-7	2000	Antioxidants, pyrrolidine dithiocarbamate, and N-acetyl-L-cysteine significantly inhibited IL-8 mRNA and protein levels by BET-1A cells.	Acetylcysteine	47-66	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
10725111-7	2000	The removal of the glass-phase iron greatly reduced the amount of iron that could be mobilized by citrate and prevented the particles from inducing interleukin-8 in cultured human lung epithelial (A549) cells.	Iron	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	148-161
10725111-7	2000	The removal of the glass-phase iron greatly reduced the amount of iron that could be mobilized by citrate and prevented the particles from inducing interleukin-8 in cultured human lung epithelial (A549) cells.	Iron	66-70	C-X-C motif chemokine ligand 8	Homo sapiens	148-161
10702362-0	2000	Cadmium-induced acute hepatic injury is exacerbated in human interleukin-8 transgenic mice.	Cadmium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
10704251-0	2000	Sesquiterpene lactones are potent inhibitors of interleukin 8 gene expression in cultured human respiratory epithelium.	sesquiterpene lactones	0-22	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	Sesquiterpenes	126-139	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	Sesquiterpenes	126-139	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	Lactones	140-148	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	Lactones	140-148	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	Lactones	140-148	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	isohelenin	150-160	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	isohelenin	150-160	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	parthenolide	165-177	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	parthenolide	165-177	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
10704251-3	2000	Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8), we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium.	parthenolide	165-177	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
10704251-5	2000	Pretreatment with either isohelenin or parthenolide inhibited TNF-alpha-mediated IL-8 gene expression in a concentration-dependent manner.	isohelenin	25-35	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
10704251-5	2000	Pretreatment with either isohelenin or parthenolide inhibited TNF-alpha-mediated IL-8 gene expression in a concentration-dependent manner.	parthenolide	39-51	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
10704251-8	2000	We conclude that sesquiterpene lactones are potent in vitro inhibitors of IL-8 gene expression in cultured human respiratory epithelium.	sesquiterpene lactones	17-39	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
10704251-11	2000	The ability of sesquiterpene lactones to modulate IL-8 gene expression may explain, in part, their anti-inflammatory effects.	sesquiterpene lactones	15-37	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
10759440-9	2000	However, MTX treatment was associated with a significant fall in serum levels of free IL-8 (p=0.03).	Methotrexate	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
10698971-9	2000	Oxidative stress (decrease of glutathione by 50%) reduced post-TNF-alpha levels of IL-6 to 14 +/- 3 and IL-8 to 1 +/- 0.2; the rise of ICAM-1 was completely blocked and E-selectin was only doubled.	Glutathione	30-41	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
10679106-0	2000	Lipoxin A4 inhibits IL-1 beta-induced IL-6, IL-8, and matrix metalloproteinase-3 production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases.	lipoxin A4	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
10679106-6	2000	At nanomolar concentrations, LXA4 inhibited these IL-1 beta responses with reduction of IL-6 and IL-8 synthesis, by 45 +/- 7% and 75 +/- 11%, respectively, and prevented IL-1 beta-induced MMP-3 synthesis without significantly affecting MMP-1 levels.	lipoxin A4	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
10630964-0	2000	The antisense oligonucleotide ISIS 2922 prevents cytomegalovirus-induced upregulation of IL-8 and ICAM-1 in cultured human fibroblasts.	Oligonucleotides	14-29	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
10711865-6	2000	Hydrocortisone (0.05 micromol/L to 50 micromol/L) inhibited cytokine release in a dose-dependent manner with ED50 values of 0.23 micromol/L, 0.19 micromol/L, and 0.10 micromol/L for IL-6, IL-8, and TNF-alpha, respectively.	Hydrocortisone	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
10679119-2	2000	Our laboratory has shown that paclitaxel induces IL-8, a member of the C-X-C family of chemokines, in subsets of human ovarian cancer cells.	Paclitaxel	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
10630964-0	2000	The antisense oligonucleotide ISIS 2922 prevents cytomegalovirus-induced upregulation of IL-8 and ICAM-1 in cultured human fibroblasts.	fomivirsen	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
10846348-0	2000	Interleukin-8 secretion by cultured oral epidermoid carcinoma cells induced with nicotine and/or arecoline treatments.	Nicotine	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
10846348-0	2000	Interleukin-8 secretion by cultured oral epidermoid carcinoma cells induced with nicotine and/or arecoline treatments.	Arecoline	97-106	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
10846348-7	2000	Nicotine and arecoline, single or combined treatment, increased IL-8 secretion in KB CCL17 cells.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
10846348-7	2000	Nicotine and arecoline, single or combined treatment, increased IL-8 secretion in KB CCL17 cells.	Arecoline	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
10656319-4	2000	NaF (1.3% by weight in the mixed cement) was added to the powder components of a glass ionomer based on LG30 glass (which contains Al, Si, Ca, P, and O only).	Silicon	135-137	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
10707023-1	2000	The "ELR" (Glu-Leu-Arg) tripeptide sequence near the N-terminus of interleukin-8 (IL-8) contributes a large part of the receptor binding free energy.	Glutamic Acid	11-14	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
10707023-1	2000	The "ELR" (Glu-Leu-Arg) tripeptide sequence near the N-terminus of interleukin-8 (IL-8) contributes a large part of the receptor binding free energy.	Glutamic Acid	11-14	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
10707023-1	2000	The "ELR" (Glu-Leu-Arg) tripeptide sequence near the N-terminus of interleukin-8 (IL-8) contributes a large part of the receptor binding free energy.	Leucine	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
10707023-1	2000	The "ELR" (Glu-Leu-Arg) tripeptide sequence near the N-terminus of interleukin-8 (IL-8) contributes a large part of the receptor binding free energy.	Leucine	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
10707023-1	2000	The "ELR" (Glu-Leu-Arg) tripeptide sequence near the N-terminus of interleukin-8 (IL-8) contributes a large part of the receptor binding free energy.	Arginine	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
10707023-1	2000	The "ELR" (Glu-Leu-Arg) tripeptide sequence near the N-terminus of interleukin-8 (IL-8) contributes a large part of the receptor binding free energy.	Arginine	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
10707023-1	2000	The "ELR" (Glu-Leu-Arg) tripeptide sequence near the N-terminus of interleukin-8 (IL-8) contributes a large part of the receptor binding free energy.	tripeptide K-26	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
10707023-1	2000	The "ELR" (Glu-Leu-Arg) tripeptide sequence near the N-terminus of interleukin-8 (IL-8) contributes a large part of the receptor binding free energy.	tripeptide K-26	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
10644044-0	2000	Inhibition of interleukin-8-activated human neutrophil chemotaxis by thapsigargin in a calcium- and cyclic AMP-dependent way.	Thapsigargin	69-81	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
10644044-0	2000	Inhibition of interleukin-8-activated human neutrophil chemotaxis by thapsigargin in a calcium- and cyclic AMP-dependent way.	Calcium	87-94	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
10644044-0	2000	Inhibition of interleukin-8-activated human neutrophil chemotaxis by thapsigargin in a calcium- and cyclic AMP-dependent way.	Cyclic AMP	100-110	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
10644044-1	2000	Chemotactic migration of human neutrophils, induced by interleukin-8 (IL-8) or other activators, was inhibited by thapsigargin in the high nanomolar range.	Thapsigargin	114-126	C-X-C motif chemokine ligand 8	Homo sapiens	55-68
10644044-1	2000	Chemotactic migration of human neutrophils, induced by interleukin-8 (IL-8) or other activators, was inhibited by thapsigargin in the high nanomolar range.	Thapsigargin	114-126	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
10644044-3	2000	Other inhibitors of Ca(2+)-ATPases associated with intracellular calcium stores, such as cyclopiazonic acid and 2,5-di-(tert-butyl)-1,4-benzohydroquinone, equally inhibited IL-8-activated migration.	cyclopiazonic acid	89-107	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
10644044-3	2000	Other inhibitors of Ca(2+)-ATPases associated with intracellular calcium stores, such as cyclopiazonic acid and 2,5-di-(tert-butyl)-1,4-benzohydroquinone, equally inhibited IL-8-activated migration.	2,5-di-tert-butylhydroquinone	112-153	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
10644044-8	2000	Cyclic AMP (cAMP; adenosine 3",5"-cyclic monophosphate) is probably involved in this process, because thapsigargin increased the cAMP level and cAMP inhibited IL-8-activated migration in a calcium-dependent way.	Cyclic AMP	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
10644044-8	2000	Cyclic AMP (cAMP; adenosine 3",5"-cyclic monophosphate) is probably involved in this process, because thapsigargin increased the cAMP level and cAMP inhibited IL-8-activated migration in a calcium-dependent way.	Cyclic AMP	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
10644044-8	2000	Cyclic AMP (cAMP; adenosine 3",5"-cyclic monophosphate) is probably involved in this process, because thapsigargin increased the cAMP level and cAMP inhibited IL-8-activated migration in a calcium-dependent way.	Cyclic AMP	18-54	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
10644044-8	2000	Cyclic AMP (cAMP; adenosine 3",5"-cyclic monophosphate) is probably involved in this process, because thapsigargin increased the cAMP level and cAMP inhibited IL-8-activated migration in a calcium-dependent way.	Thapsigargin	102-114	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
10644044-8	2000	Cyclic AMP (cAMP; adenosine 3",5"-cyclic monophosphate) is probably involved in this process, because thapsigargin increased the cAMP level and cAMP inhibited IL-8-activated migration in a calcium-dependent way.	Calcium	189-196	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
10656319-4	2000	NaF (1.3% by weight in the mixed cement) was added to the powder components of a glass ionomer based on LG30 glass (which contains Al, Si, Ca, P, and O only).	lg30	104-108	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
10656319-4	2000	NaF (1.3% by weight in the mixed cement) was added to the powder components of a glass ionomer based on LG30 glass (which contains Al, Si, Ca, P, and O only).	Aluminum	131-133	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
10855853-0	2000	In vitro interleukin-8 production by monocytes treated with lithium chloride from breast cancer patients.	Lithium Chloride	60-76	C-X-C motif chemokine ligand 8	Homo sapiens	9-22
10855853-1	2000	AIMS AND BACKGROUND: Since interleukin-8 (IL-8) has a suppressive effect on hematopoiesis, lithium induces leukocytosis and granulocytosis and mononuclear cells are defective in patients affected by neoplastic disease, we analyzed IL-8 production by monocytes obtained from patients with nonmetastatic breast cancer (BCaM0) and metastatic breast cancer (BCaM1) and the effect of lithium chloride (LiCl) on these cells.	Lithium	91-98	C-X-C motif chemokine ligand 8	Homo sapiens	231-235
10855853-3	2000	Lithium influences the hematopoietic system, which is known to be regulated by numerous cytokines including IL-8.	Lithium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
10855853-5	2000	IL-8 release was assessed in supernatants of lipopolysaccharide (LPS) and/or LiCl-treated monocyte cultures.	Lithium Chloride	77-81	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10855853-7	2000	In vitro LiCl treatment reduced IL-8 production by monocytes obtained from all subjects compared to the same cells when untreated or LPS treated.	Lithium Chloride	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
10855853-8	2000	The suppressive effect of LiCl on IL-8 production by monocytes from breast cancer patients was particularly marked in monocytes from BCaM0 with respect to those from BCaM1.	Lithium Chloride	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
10855853-10	2000	Moreover, combined LPS/LiCl treatment of monocytes significantly (p &lt;0.0001) downregulated the release of IL-8 compared to treatment with LPS alone.	Lithium Chloride	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
10855853-12	2000	Lithium was able to downregulate IL-8 production by monocytes from different subgroups.	Lithium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
10657941-8	2000	In contrast to AMs, MO adhesion or exposure to ROFA particles in suspension rapidly activated p38, JNK, and ERK/MAPK, and activated NF-kappaB binding as well as IL-8 mRNA expression.	rofa	47-51	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
10656319-4	2000	NaF (1.3% by weight in the mixed cement) was added to the powder components of a glass ionomer based on LG30 glass (which contains Al, Si, Ca, P, and O only).	Phosphorus	143-144	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
10656319-16	2000	Fluoride addition to a F-free glass ionomer renders it vulnerable to surface disruption by NaF solution showing that fluoride complexes produced in glass dissolution are not necessarily involved in this process.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	91-94
10656319-17	2000	Sodium addition to a Na-free glass ionomer confirms the role of this cement in enhancing pH change in NaF solution.	Sodium	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
10688536-2	2000	We tested the hypothesis that iron present in coal fly ash (CFA) could induce the expression and synthesis of the inflammatory cytokine interleukin-8 (IL-8).	Iron	30-34	C-X-C motif chemokine ligand 8	Homo sapiens	136-149
10653823-6	2000	Preexposure of ECs for 18 hours with laminar shear stress (15 dyne/cm(2)) abrogated CS-induced IL-8 release to 106+/-10% (P&lt;0.001) and reduced CS-induced MCP-1 expression (170+/-31%; P&lt;0.05).	Cesium	84-86	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
10653823-9	2000	Specific inhibition of clusterin by transfection with antisense oligonucleotides reversed the protective effect of shear stress on CS-induced MCP-1 and IL-8 upregulation (P&lt;0.05 versus sense-transfected cells).	Oligonucleotides	64-80	C-X-C motif chemokine ligand 8	Homo sapiens	152-156
10653823-9	2000	Specific inhibition of clusterin by transfection with antisense oligonucleotides reversed the protective effect of shear stress on CS-induced MCP-1 and IL-8 upregulation (P&lt;0.05 versus sense-transfected cells).	Cesium	131-133	C-X-C motif chemokine ligand 8	Homo sapiens	152-156
10688536-0	2000	Interleukin-8 levels in human lung epithelial cells are increased in response to coal fly ash and vary with the bioavailability of iron, as a function of particle size and source of coal.	Iron	131-135	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
10688536-2	2000	We tested the hypothesis that iron present in coal fly ash (CFA) could induce the expression and synthesis of the inflammatory cytokine interleukin-8 (IL-8).	Iron	30-34	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
10688536-2	2000	We tested the hypothesis that iron present in coal fly ash (CFA) could induce the expression and synthesis of the inflammatory cytokine interleukin-8 (IL-8).	3-chloro-4-fluoroaniline	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	136-149
10688536-2	2000	We tested the hypothesis that iron present in coal fly ash (CFA) could induce the expression and synthesis of the inflammatory cytokine interleukin-8 (IL-8).	3-chloro-4-fluoroaniline	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
10688536-5	2000	Treatment of human lung epithelial (A549) cells for 4 h with CFA from Utah enriched in &lt;1 micrometer particles (20 microgram/cm(2)) resulted in a 2.6-fold increase in mRNA levels for IL-8.	3-chloro-4-fluoroaniline	61-64	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
10688536-6	2000	IL-8 levels were increased in the medium by as much as 8-fold when cells were treated with the fraction enriched in the smallest size Utah CFA for 24 h. IL-8 production was completely inhibited when the CFA was pretreated with the metal chelator desferrioxamine B, suggesting that a transition metal was responsible for the induction, probably iron.	3-chloro-4-fluoroaniline	139-142	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10688536-6	2000	IL-8 levels were increased in the medium by as much as 8-fold when cells were treated with the fraction enriched in the smallest size Utah CFA for 24 h. IL-8 production was completely inhibited when the CFA was pretreated with the metal chelator desferrioxamine B, suggesting that a transition metal was responsible for the induction, probably iron.	3-chloro-4-fluoroaniline	139-142	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
10688536-6	2000	IL-8 levels were increased in the medium by as much as 8-fold when cells were treated with the fraction enriched in the smallest size Utah CFA for 24 h. IL-8 production was completely inhibited when the CFA was pretreated with the metal chelator desferrioxamine B, suggesting that a transition metal was responsible for the induction, probably iron.	3-chloro-4-fluoroaniline	203-206	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10688536-6	2000	IL-8 levels were increased in the medium by as much as 8-fold when cells were treated with the fraction enriched in the smallest size Utah CFA for 24 h. IL-8 production was completely inhibited when the CFA was pretreated with the metal chelator desferrioxamine B, suggesting that a transition metal was responsible for the induction, probably iron.	3-chloro-4-fluoroaniline	203-206	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
10688536-6	2000	IL-8 levels were increased in the medium by as much as 8-fold when cells were treated with the fraction enriched in the smallest size Utah CFA for 24 h. IL-8 production was completely inhibited when the CFA was pretreated with the metal chelator desferrioxamine B, suggesting that a transition metal was responsible for the induction, probably iron.	Metals	231-236	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10688536-6	2000	IL-8 levels were increased in the medium by as much as 8-fold when cells were treated with the fraction enriched in the smallest size Utah CFA for 24 h. IL-8 production was completely inhibited when the CFA was pretreated with the metal chelator desferrioxamine B, suggesting that a transition metal was responsible for the induction, probably iron.	Metals	231-236	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
10688536-6	2000	IL-8 levels were increased in the medium by as much as 8-fold when cells were treated with the fraction enriched in the smallest size Utah CFA for 24 h. IL-8 production was completely inhibited when the CFA was pretreated with the metal chelator desferrioxamine B, suggesting that a transition metal was responsible for the induction, probably iron.	Deferoxamine	246-263	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10688536-6	2000	IL-8 levels were increased in the medium by as much as 8-fold when cells were treated with the fraction enriched in the smallest size Utah CFA for 24 h. IL-8 production was completely inhibited when the CFA was pretreated with the metal chelator desferrioxamine B, suggesting that a transition metal was responsible for the induction, probably iron.	Deferoxamine	246-263	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
10688536-6	2000	IL-8 levels were increased in the medium by as much as 8-fold when cells were treated with the fraction enriched in the smallest size Utah CFA for 24 h. IL-8 production was completely inhibited when the CFA was pretreated with the metal chelator desferrioxamine B, suggesting that a transition metal was responsible for the induction, probably iron.	Metals	294-299	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10688536-6	2000	IL-8 levels were increased in the medium by as much as 8-fold when cells were treated with the fraction enriched in the smallest size Utah CFA for 24 h. IL-8 production was completely inhibited when the CFA was pretreated with the metal chelator desferrioxamine B, suggesting that a transition metal was responsible for the induction, probably iron.	Metals	294-299	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
10688536-6	2000	IL-8 levels were increased in the medium by as much as 8-fold when cells were treated with the fraction enriched in the smallest size Utah CFA for 24 h. IL-8 production was completely inhibited when the CFA was pretreated with the metal chelator desferrioxamine B, suggesting that a transition metal was responsible for the induction, probably iron.	Iron	344-348	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10688536-6	2000	IL-8 levels were increased in the medium by as much as 8-fold when cells were treated with the fraction enriched in the smallest size Utah CFA for 24 h. IL-8 production was completely inhibited when the CFA was pretreated with the metal chelator desferrioxamine B, suggesting that a transition metal was responsible for the induction, probably iron.	Iron	344-348	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
10688536-7	2000	Treatment with a soluble form of iron, ferric ammonium citrate (FAC), mimicked the IL-8 level increase observed with CFA.	Iron	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
10688536-7	2000	Treatment with a soluble form of iron, ferric ammonium citrate (FAC), mimicked the IL-8 level increase observed with CFA.	ferric ammonium citrate	39-62	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
10688536-8	2000	There was a direct relationship, above a threshold level of bioavailable iron, between the levels of IL-8 and bioavailable iron in A549 cells treated with CFA or FAC.	Iron	73-77	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
10706503-2	2000	This study has tested the hypothesis that T-cell chemotaxis induced by platelet-activating factor (PAF) and human recombinant interleukin-8 (hrIL-8) can be attenuated by inhibition of phosphodiesterase activity and raised intracellular 3",5"-cyclic adenosine monophosphate (cAMP) levels.	3",5"-cyclic adenosine monophosphate	236-272	C-X-C motif chemokine ligand 8	Homo sapiens	126-139
10688536-8	2000	There was a direct relationship, above a threshold level of bioavailable iron, between the levels of IL-8 and bioavailable iron in A549 cells treated with CFA or FAC.	Iron	123-127	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
10706503-2	2000	This study has tested the hypothesis that T-cell chemotaxis induced by platelet-activating factor (PAF) and human recombinant interleukin-8 (hrIL-8) can be attenuated by inhibition of phosphodiesterase activity and raised intracellular 3",5"-cyclic adenosine monophosphate (cAMP) levels.	Cyclic AMP	274-278	C-X-C motif chemokine ligand 8	Homo sapiens	126-139
10688536-9	2000	Further, the relationship between IL-8 and bioavailable iron for CFA was indistinguishable from that for FAC.	Iron	56-60	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
10688536-10	2000	These results strongly suggest that iron can induce IL-8 in A549 cells and that iron was the likely component of CFA that induced IL-8.	Iron	36-40	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
10688536-10	2000	These results strongly suggest that iron can induce IL-8 in A549 cells and that iron was the likely component of CFA that induced IL-8.	Iron	80-84	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
10688536-11	2000	CFA-induced IL-8 production was inhibited by tetramethylthiourea or dimethyl sulfoxide, suggesting that radical species were involved in the induction.	3-chloro-4-fluoroaniline	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
10688536-11	2000	CFA-induced IL-8 production was inhibited by tetramethylthiourea or dimethyl sulfoxide, suggesting that radical species were involved in the induction.	tetramethylthiourea	45-64	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
10688536-11	2000	CFA-induced IL-8 production was inhibited by tetramethylthiourea or dimethyl sulfoxide, suggesting that radical species were involved in the induction.	Dimethyl Sulfoxide	68-86	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
10685001-8	2000	Eighteen hour cytokine treatments with GM-CSF, IL-8, RANTES, IFN-gamma or TNF-alpha primed the cells for enhanced reactive oxygen species following exposure to an EOS stimulant.	Reactive Oxygen Species	114-137	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
10615065-3	2000	In the present study we investigated the effects of clarithromycin (CAM) on interleukin (IL)-8 gene expression and protein levels, using the human bronchial epithelial cell line BET-1A.	Clarithromycin	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	76-94
11450070-4	2000	The ischemia-induced expression of ICAM-1 in HCEC, and the expression/release of IL-8 and MCP-1 in HCEC were abolished by the non-steroid anti-inflammatory drug, indomethacin (100-300 microM).	Indomethacin	162-174	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
11450070-5	2000	The immunosuppressant cyclosporin A (50 microM) partially reduced the ischemia-stimulated IL-8 and MCP-1 secretion by HCEC.	Cyclosporine	22-35	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
10640773-3	2000	Exogenous hydrogen peroxide and neutrophils activated by IL-8, FMLP, or TNF-alpha increased EGFR tyrosine phosphorylation and subsequent activation of p44/42mapk and up-regulated the expression of MUC5AC at both mRNA and protein levels in NCI-H292 cells.	Hydrogen Peroxide	10-27	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
10640773-3	2000	Exogenous hydrogen peroxide and neutrophils activated by IL-8, FMLP, or TNF-alpha increased EGFR tyrosine phosphorylation and subsequent activation of p44/42mapk and up-regulated the expression of MUC5AC at both mRNA and protein levels in NCI-H292 cells.	Tyrosine	97-105	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
10620700-2	2000	Pretreatment of RSF with a specific p38 MAP kinase inhibitor, SB203580, blocked the induction of IL-6 and IL-8 without affecting nuclear translocation of nuclear factor kappaB (NF-kappaB) or IL-6 and IL-8 mRNA levels.	(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
10620700-2	2000	Pretreatment of RSF with a specific p38 MAP kinase inhibitor, SB203580, blocked the induction of IL-6 and IL-8 without affecting nuclear translocation of nuclear factor kappaB (NF-kappaB) or IL-6 and IL-8 mRNA levels.	(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
10620700-2	2000	Pretreatment of RSF with a specific p38 MAP kinase inhibitor, SB203580, blocked the induction of IL-6 and IL-8 without affecting nuclear translocation of nuclear factor kappaB (NF-kappaB) or IL-6 and IL-8 mRNA levels.	SB 203580	62-70	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
10615065-0	2000	Interleukin-8 gene repression by clarithromycin is mediated by the activator protein-1 binding site in human bronchial epithelial cells.	Clarithromycin	33-47	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
10615065-3	2000	In the present study we investigated the effects of clarithromycin (CAM) on interleukin (IL)-8 gene expression and protein levels, using the human bronchial epithelial cell line BET-1A.	Clarithromycin	52-66	C-X-C motif chemokine ligand 8	Homo sapiens	76-94
10619832-6	2000	SB 203580, as the specific inhibitor of p38 MAP kinase activity, inhibited DEP-induced IL-8 and RANTES production.	SB 203580	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
10619832-7	2000	NAC inhibited DEP-induced p38 MAP kinase activation and IL-8 and RANTES production.	Acetylcysteine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
10615065-12	2000	These data suggest that macrolides such as CAM repress IL-8 gene transcription mainly via the AP-1 binding site in human bronchial epithelial cells.	Macrolides	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
10615065-12	2000	These data suggest that macrolides such as CAM repress IL-8 gene transcription mainly via the AP-1 binding site in human bronchial epithelial cells.	Clarithromycin	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
10853906-4	2000	The aim of the present study was to examine interleukin-8 (IL-8) in the synovial-like interface membrane (SLIM) and pseudocapsular tissue of THRs and to compare it to normal knee synovial membrane.	Threonine	141-145	C-X-C motif chemokine ligand 8	Homo sapiens	44-57
10853906-4	2000	The aim of the present study was to examine interleukin-8 (IL-8) in the synovial-like interface membrane (SLIM) and pseudocapsular tissue of THRs and to compare it to normal knee synovial membrane.	Threonine	141-145	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
10853906-13	2000	The present study determines for the first time the cellular origin of IL-8 in aseptically loosened THRs and also quantitates the IL-8-producing cells in the periprosthetic tissue.	Threonine	100-104	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
10867834-2	2000	We examined the in vivo and in vitro effects of 14-membered macrolide antibiotics erythromycin (EM) and clarithromycin (CAM) on interleukin (IL)-8 secretion from human nasal epithelial cells.	Erythromycin	96-98	C-X-C motif chemokine ligand 8	Homo sapiens	128-146
10971057-0	2000	Adamantiades-Behcet"s disease: serum IL-8 is a more reliable marker for disease activity than C-reactive protein and erythrocyte sedimentation rate.	adamantiades	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
10971057-1	2000	BACKGROUND: Interleukin 8 (IL-8) has recently been under focused investigation because of its possible participation in the evolution of Adamantiades-Behcet"s disease.	adamantiades	137-149	C-X-C motif chemokine ligand 8	Homo sapiens	12-25
10971057-1	2000	BACKGROUND: Interleukin 8 (IL-8) has recently been under focused investigation because of its possible participation in the evolution of Adamantiades-Behcet"s disease.	adamantiades	137-149	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
10971057-8	2000	CONCLUSION: Our results confirm previous data concerning the significance of IL-8 and, in addition, they provide first evidence for the reliability of IL-8 as a serological marker for assessment of the activity of Adamantiades-Behcet"s disease in the follow-up of clinical and therapeutic studies.	adamantiades	214-226	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
10623446-3	2000	The effect of modulating IL-8 activity upon the growth of the colon carcinoma cell lines HCT116A, HT29 and CaCo2 was investigated.	caco2	107-112	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
10867834-0	2000	Effects of macrolides on interleukin-8 secretion from human nasal epithelial cells.	Macrolides	11-21	C-X-C motif chemokine ligand 8	Homo sapiens	25-38
10867834-2	2000	We examined the in vivo and in vitro effects of 14-membered macrolide antibiotics erythromycin (EM) and clarithromycin (CAM) on interleukin (IL)-8 secretion from human nasal epithelial cells.	Clarithromycin	104-118	C-X-C motif chemokine ligand 8	Homo sapiens	128-146
10867834-2	2000	We examined the in vivo and in vitro effects of 14-membered macrolide antibiotics erythromycin (EM) and clarithromycin (CAM) on interleukin (IL)-8 secretion from human nasal epithelial cells.	Clarithromycin	120-123	C-X-C motif chemokine ligand 8	Homo sapiens	128-146
10867834-2	2000	We examined the in vivo and in vitro effects of 14-membered macrolide antibiotics erythromycin (EM) and clarithromycin (CAM) on interleukin (IL)-8 secretion from human nasal epithelial cells.	14-membered macrolide antibiotics	48-81	C-X-C motif chemokine ligand 8	Homo sapiens	128-146
10867834-7	2000	When cells were preincubated with 10(-4) M CAM for 7 days, the IL-1 beta-induced secretion of IL-8 decreased significantly.	Clarithromycin	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
10867834-2	2000	We examined the in vivo and in vitro effects of 14-membered macrolide antibiotics erythromycin (EM) and clarithromycin (CAM) on interleukin (IL)-8 secretion from human nasal epithelial cells.	Erythromycin	82-94	C-X-C motif chemokine ligand 8	Homo sapiens	128-146
10867834-9	2000	These results suggest that macrolide treatment inhibits neutrophil infiltration and IL-8 secretion in nasal epithelium in vivo and that these clinical effects depend on a mechanism other than the direct action of macrolide on nasal epithelial cells.	Macrolides	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
10671814-4	2000	However, the increases in PGE(2) production by IL-6 and IL-8 were found at relatively high concentrations, i.e. at 100 and 200 ng/ml.	Prostaglandins E	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
12881895-8	2000	However, much more IL-8 was released into the tissue culture supernatant by SiO2 at the same levels of cytotoxicity than by Ni3S2.	Silicon Dioxide	76-80	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
10603404-9	2000	In contrast to the response to LPS, where TNF-alpha, IL-1beta, IL-6, and IL-8 appear almost simultaneously, the human monocyte response to GBS results in the production of TNF-alpha but delayed appearance of IL-1beta, IL-6, and IL-8.	gbs	139-142	C-X-C motif chemokine ligand 8	Homo sapiens	228-232
12881895-8	2000	However, much more IL-8 was released into the tissue culture supernatant by SiO2 at the same levels of cytotoxicity than by Ni3S2.	ni3s2	124-129	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
10954057-4	2000	LPS also stimulated secretion of IL-6 and IL-8 in cultured trophoblasts, which was suppressed by nafamostat mesilate.	nafamostat	97-116	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
11240649-0	2000	Cytokines IL-1beta, IL-2, IL-6, IL-8, MCP-1, GM-CSF and TNFalpha in patients with epithelial ovarian cancer and their relationship to treatment with paclitaxel.	Paclitaxel	149-159	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
11240649-7	2000	In serum, IL-6, IL-8 and MCP-1 decreased with the administration of steroids prior to paclitaxel, and increased in the 24 h after paclitaxel.	Steroids	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
11240649-10	2000	Treatment with paclitaxel is associated with an increase in expression of a limited number of cytokines in patients with ovarian cancer, notably IL-6, IL-8 and MCP-1.	Paclitaxel	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
10970000-0	2000	Identification of a possible association between carbon tetrachloride-induced hepatotoxicity and interleukin-8 expression.	Carbon Tetrachloride	49-69	C-X-C motif chemokine ligand 8	Homo sapiens	97-110
10970000-8	2000	We also found that carbon tetrachloride caused a time-dependent increase in interleukin-8 protein release in HepG2 cells, which was paralleled by a decrease in cell viability.	Carbon Tetrachloride	19-39	C-X-C motif chemokine ligand 8	Homo sapiens	76-89
10970000-9	2000	These data demonstrate that carbon tetrachloride causes a rapid increase in IL-8 mRNA expression in HepG2 cells and that this increase correlates with a later and significant increase in the levels of interleukin-8 protein.	Carbon Tetrachloride	28-48	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
10970000-9	2000	These data demonstrate that carbon tetrachloride causes a rapid increase in IL-8 mRNA expression in HepG2 cells and that this increase correlates with a later and significant increase in the levels of interleukin-8 protein.	Carbon Tetrachloride	28-48	C-X-C motif chemokine ligand 8	Homo sapiens	201-214
10732314-2	2000	METHODS: Amnion-derived WISH cells were treated with a range of prostanoids and their effects on production of interleukin (IL)-6 and IL-8 were determined by enzyme-linked immunosorbent assay and Northern analysis.	Prostaglandins	64-75	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
10670836-0	2000	Grepafloxacin inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in human airway epithelial cells.	grepafloxacin	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	59-72
10670836-1	2000	We examined the effect of grepafloxacin (GPFX), a new fluoroquinolone antimicrobial agent, on interleukin-8 (IL-8) expression in tumor necrosis factor-alpha (TNF-alpha)-stimulated human airway epithelial cells (AEC).	grepafloxacin	26-39	C-X-C motif chemokine ligand 8	Homo sapiens	94-107
10670836-1	2000	We examined the effect of grepafloxacin (GPFX), a new fluoroquinolone antimicrobial agent, on interleukin-8 (IL-8) expression in tumor necrosis factor-alpha (TNF-alpha)-stimulated human airway epithelial cells (AEC).	grepafloxacin	26-39	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
10670836-1	2000	We examined the effect of grepafloxacin (GPFX), a new fluoroquinolone antimicrobial agent, on interleukin-8 (IL-8) expression in tumor necrosis factor-alpha (TNF-alpha)-stimulated human airway epithelial cells (AEC).	grepafloxacin	41-45	C-X-C motif chemokine ligand 8	Homo sapiens	94-107
10670836-1	2000	We examined the effect of grepafloxacin (GPFX), a new fluoroquinolone antimicrobial agent, on interleukin-8 (IL-8) expression in tumor necrosis factor-alpha (TNF-alpha)-stimulated human airway epithelial cells (AEC).	grepafloxacin	41-45	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
10670836-1	2000	We examined the effect of grepafloxacin (GPFX), a new fluoroquinolone antimicrobial agent, on interleukin-8 (IL-8) expression in tumor necrosis factor-alpha (TNF-alpha)-stimulated human airway epithelial cells (AEC).	Fluoroquinolones	54-69	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
10670836-3	2000	We discuss the modulatory effect of GPFX on IL-8 production in the context of its efficacy on controlling chronic airway inflammatory diseases.	grepafloxacin	36-40	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
10941934-6	2000	Compared with that by viable bacterial cells, IL-8 secretion by stimulated epithelial cells and monocytes was reduced when the bacteria were heated and treated with glutaraldehyde.	Glutaral	165-179	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
11188927-10	2000	For the dose-dependent differences of the effect of interleukin-8 we propose a two wheel model of an inositolphosphate-mediated, ATP-independent release of calcium from intracellular stores and a cyclic AMP-mediated, ATP-dependent uptake of calcium into the endoplasmatic reticulum.	Inositol Phosphates	101-118	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
11188927-10	2000	For the dose-dependent differences of the effect of interleukin-8 we propose a two wheel model of an inositolphosphate-mediated, ATP-independent release of calcium from intracellular stores and a cyclic AMP-mediated, ATP-dependent uptake of calcium into the endoplasmatic reticulum.	Adenosine Triphosphate	129-132	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
11188927-10	2000	For the dose-dependent differences of the effect of interleukin-8 we propose a two wheel model of an inositolphosphate-mediated, ATP-independent release of calcium from intracellular stores and a cyclic AMP-mediated, ATP-dependent uptake of calcium into the endoplasmatic reticulum.	Calcium	156-163	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
11188927-10	2000	For the dose-dependent differences of the effect of interleukin-8 we propose a two wheel model of an inositolphosphate-mediated, ATP-independent release of calcium from intracellular stores and a cyclic AMP-mediated, ATP-dependent uptake of calcium into the endoplasmatic reticulum.	Cyclic AMP	196-206	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
11188927-10	2000	For the dose-dependent differences of the effect of interleukin-8 we propose a two wheel model of an inositolphosphate-mediated, ATP-independent release of calcium from intracellular stores and a cyclic AMP-mediated, ATP-dependent uptake of calcium into the endoplasmatic reticulum.	Adenosine Triphosphate	217-220	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
11188927-10	2000	For the dose-dependent differences of the effect of interleukin-8 we propose a two wheel model of an inositolphosphate-mediated, ATP-independent release of calcium from intracellular stores and a cyclic AMP-mediated, ATP-dependent uptake of calcium into the endoplasmatic reticulum.	Calcium	241-248	C-X-C motif chemokine ligand 8	Homo sapiens	52-65
11132774-7	2000	However, only basal secretion of interleukin-8 in both undifferentiated and DMSO-differentiated U937 cells was significantly reduced by CsA at the highest concentration (200 ng/ mL).	Dimethyl Sulfoxide	76-80	C-X-C motif chemokine ligand 8	Homo sapiens	33-46
11132774-7	2000	However, only basal secretion of interleukin-8 in both undifferentiated and DMSO-differentiated U937 cells was significantly reduced by CsA at the highest concentration (200 ng/ mL).	Cyclosporine	136-139	C-X-C motif chemokine ligand 8	Homo sapiens	33-46
11132774-8	2000	At therapeutic concentrations in vivo, CsA exerts a predominant effect on IL-8 secretion by human mononuclear phagocytes.	Cyclosporine	39-42	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
10616000-7	1999	Tau-Cl, but not Tau, inhibited cytokine-triggered synthesis of IL-6 (50% inhibitory concentration [IC50] approximately 225 microM) and IL-8 (IC50 approximately 450 microM) when added simultaneously with the stimuli.	tau-cl	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
10683319-3	2000	Tetradecanoyl phorbol acetate (TPA) strongly increased the IL-8 and MCP-1 amounts in the culture supernatants of all five cell lines.	Tetradecanoylphorbol Acetate	0-29	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
10683319-3	2000	Tetradecanoyl phorbol acetate (TPA) strongly increased the IL-8 and MCP-1 amounts in the culture supernatants of all five cell lines.	Tetradecanoylphorbol Acetate	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
10867611-0	2000	Fluticasone propionate reduces serum interleukin-8 levels in asthmatic patients.	Fluticasone	0-22	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
10619350-9	1999	RESULTS: There was a significant reduction in levels of TNF-alpha and IL-6 at a furosemide concentration of 0.5 x 10(-2) M and a reduction in IL-8 levels at 10(-2) M. This inhibition was comparable to that found with equivalent molar concentrations of hydrocortisone.	Hydrocortisone	252-266	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
10559516-6	1999	However, IL-1beta-induced productions of both MCP-1 and IL-8 were dose-dependently suppressed by enrichment of cells with vitamin E.	Vitamin E	122-131	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
10593333-10	1999	Production of IL-8, in response to LPS alone or in combination with PAF, was inhibited by SB202190, a specific p38 inhibitor.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	90-98	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
10594545-10	1999	CONCLUSIONS: These results suggest that cetirizine reduced the release of IL-8 from A549 cells stimulated with PMA and TNF-alpha, respectively, by lowering IL-8 gene expression.	Cetirizine	40-50	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
10594545-0	1999	Cetirizine counter-regulates interleukin-8 release from human epithelial cells (A549) BACKGROUND: Cetirizine, a H1-receptor antagonist, exerts besides its well-known anti-allergic potential an array of anti-inflammatory activities.	Cetirizine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	29-42
10594545-10	1999	CONCLUSIONS: These results suggest that cetirizine reduced the release of IL-8 from A549 cells stimulated with PMA and TNF-alpha, respectively, by lowering IL-8 gene expression.	Cetirizine	40-50	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
10594545-0	1999	Cetirizine counter-regulates interleukin-8 release from human epithelial cells (A549) BACKGROUND: Cetirizine, a H1-receptor antagonist, exerts besides its well-known anti-allergic potential an array of anti-inflammatory activities.	Cetirizine	98-108	C-X-C motif chemokine ligand 8	Homo sapiens	29-42
10623427-12	1999	These results indicate that IL-8 synergizes and LIF potentiates the TNF-alpha PGE(2)effect which appears to be mediated mostly by increasing cPLA2 activity level.	Prostaglandins E	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
10594545-2	1999	OBJECTIVE: We wondered whether cetirizine might influence the release of interleukin-8 (IL-8) from human epithelial cells activated with agonists distinct from histamine.	Cetirizine	31-41	C-X-C motif chemokine ligand 8	Homo sapiens	73-86
10594545-2	1999	OBJECTIVE: We wondered whether cetirizine might influence the release of interleukin-8 (IL-8) from human epithelial cells activated with agonists distinct from histamine.	Cetirizine	31-41	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
10594545-6	1999	Pre-incubation with cetirizine diminished the IL-8 release from cells activated with TNF-alpha or PMA in a significant manner.	Cetirizine	20-30	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
10594545-8	1999	Northern blot analysis revealed a reduced steady state level of IL-8 mRNA in cells pretreated with cetirizine and stimulated with TNF-alpha.	Cetirizine	99-109	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
10588510-3	1999	We evaluated the interactions of IL-8 and GRO-alpha in priming human PMN calcium fluxes [Ca2+]i within circulatory environments.	Calcium	73-80	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
10786156-5	1999	The amounts of fluoride recharged in RGIs increased with the concentration of NaF solution, but those of PMCRs exposed to all concentrations of NaF solutions were less than 1.5 ppm.	Fluorides	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	78-81
10786156-5	1999	The amounts of fluoride recharged in RGIs increased with the concentration of NaF solution, but those of PMCRs exposed to all concentrations of NaF solutions were less than 1.5 ppm.	Compomers	105-110	C-X-C motif chemokine ligand 8	Homo sapiens	144-147
10583451-1	1999	BACKGROUND: Capillary leakage of sodium-fluorescein (NaF) in the skin reflects capillary permeability and may be a marker of diabetes-associated microcirculatory abnormalities.	Fluorescein	33-51	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
10583451-6	1999	Enalapril reduced NaF leakage (P &lt; 0.05), mean arterial blood pressure (P &lt; 0.05) and microalbuminuria (P &lt; 0.	Enalapril	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
10624772-6	1999	Furthermore, IL-8, Gro and MCP-1 concentrations decreased between 24 and 72 h. Immunocytochemistry indicated expression of IL-8 by pleural mesothelial cells 24 h, but not 72 h, following TCN administration.	Tetracycline	187-190	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
10624772-6	1999	Furthermore, IL-8, Gro and MCP-1 concentrations decreased between 24 and 72 h. Immunocytochemistry indicated expression of IL-8 by pleural mesothelial cells 24 h, but not 72 h, following TCN administration.	Tetracycline	187-190	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
10624772-7	1999	The data suggest that local elaboration of interleukin-8 and growth-related protein, in part of mesothelial origin, may influence neutrophil recruitment in tetracycline-induced pleuritis.	Tetracycline	156-168	C-X-C motif chemokine ligand 8	Homo sapiens	43-56
10570304-0	1999	Lipoteichoic acid inhibits lipopolysaccharide-induced adhesion molecule expression and IL-8 release in human lung microvascular endothelial cells.	lipoteichoic acid	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
10570304-2	1999	This study investigated the effects of lipoteichoic acid (LTA), a cell wall component of Gram-positive bacteria, alone and with LPS or TNF-alpha, on CAM expression and IL-8 release in human lung microvascular endothelial cells (HLMVEC).	lipoteichoic acid	39-56	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
10570306-10	1999	Furthermore, MIP-2 and truncated GCP-2(9-78), but not intact GCP-2(1-92)/LIX, partially desensitized the calcium response to human IL-8 in human neutrophils.	Calcium	105-112	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
10605950-13	1999	The next morning after exercise, the LPS-induced IL-8 production increased 137, 89, and 96%, respectively, in control, low-, and high-dose wine groups, probably due to a rise in epinephrine and activation of platelets.	lps	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
10605950-13	1999	The next morning after exercise, the LPS-induced IL-8 production increased 137, 89, and 96%, respectively, in control, low-, and high-dose wine groups, probably due to a rise in epinephrine and activation of platelets.	Epinephrine	178-189	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
10622468-0	1999	Interleukin-8 stimulates placental prostacyclin production in preeclampsia.	Epoprostenol	35-47	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
10622468-1	1999	PROBLEM: Our purpose was to determine placental interleukin (IL)-8 production and its correlation with the prostacyclin production in normal and preeclamptic pregnancies and to evaluate the beneficial effect of IL-8 on prostacyclin production.	Epoprostenol	107-119	C-X-C motif chemokine ligand 8	Homo sapiens	48-66
10622468-1	1999	PROBLEM: Our purpose was to determine placental interleukin (IL)-8 production and its correlation with the prostacyclin production in normal and preeclamptic pregnancies and to evaluate the beneficial effect of IL-8 on prostacyclin production.	Epoprostenol	219-231	C-X-C motif chemokine ligand 8	Homo sapiens	211-215
10622468-2	1999	METHOD OF STUDY: We determined 1) the in vitro production of IL-8 and prostacyclin by placental villous tissues from normal and preeclamptic pregnancies and 2) the production of prostacyclin by villous tissues from preeclampsia treated with recombinant human IL-8 (rhIL-8).	Epoprostenol	178-190	C-X-C motif chemokine ligand 8	Homo sapiens	259-263
10622468-6	1999	3) Placental tissues treated with IL-8 exhibited a concentration-dependent increase in 6-keto PGF1alpha production.	6-Ketoprostaglandin F1 alpha	87-103	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
10622468-7	1999	CONCLUSIONS: Placental tissues from preeclampsia produce significantly less IL-8 than tissues from normal pregnancies, which correlates with decreased prostacyclin production.	Epoprostenol	151-163	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
10622468-8	1999	IL-8 improves placental prostacyclin production in preeclampsia.	Epoprostenol	24-36	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10614789-7	1999	Using a naturally occurring compound found in the colon of vertebrates, butyrate, we provide evidence in an intestinal cell line that alteration of IkappaB-beta expression can modulate the transcriptional activation of the interleukin-8 (IL-8) gene by preventing the nuclear translocation of NF-kappaB proteins.	Butyrates	72-80	C-X-C motif chemokine ligand 8	Homo sapiens	223-236
10614789-7	1999	Using a naturally occurring compound found in the colon of vertebrates, butyrate, we provide evidence in an intestinal cell line that alteration of IkappaB-beta expression can modulate the transcriptional activation of the interleukin-8 (IL-8) gene by preventing the nuclear translocation of NF-kappaB proteins.	Butyrates	72-80	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
10620157-7	1999	The fluoride release for all of the materials increased after each exposure to NaF; however, the amount for the composite was very low.	Fluorides	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
10587368-6	1999	Disruption of the actin cytoskeleton by treating ESC with cytochalasin D completely blocked the increase of IL-8 that was induced in response to integrin activation.	Cytochalasin D	58-72	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
10657523-6	1999	BEAS-2B cells also responded to the botanical irritant, capsaicin (10 microM) with increases in [Ca(2+)](i) and IL-8 cytokine release after 4 h exposure.	Capsaicin	56-65	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
10657523-7	1999	The IL-8 release was dependent on the presence of extracellular calcium.	Calcium	64-71	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
10718111-1	1999	Increased production of prostaglandins and cytokines by amnion, particularly prostaglandin (PG) E2, interleukin (IL)-6 and IL-8, is thought to be an important event in infection-associated preterm labour.	Prostaglandins	24-38	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
20654562-12	1999	BC, Triton X100 and DNCB upregulated IL-8 mRNA expression while only BC induced a significant increase in IL-1alpha mRNA expression.	Octoxynol	4-15	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
20654562-12	1999	BC, Triton X100 and DNCB upregulated IL-8 mRNA expression while only BC induced a significant increase in IL-1alpha mRNA expression.	Dinitrochlorobenzene	20-24	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
20654562-15	1999	Our data demonstrate that divergent IL-1alpha and IL-8 release profiles and corresponding mRNA upregulation characterize the response to the tested irritants and DNCB.	Dinitrochlorobenzene	162-166	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
10553038-0	1999	Roles of intracellular calcium and NF-kappa B in the Clostridium difficile toxin A-induced up-regulation and secretion of IL-8 from human monocytes.	Calcium	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
10553038-5	1999	Toxin A induced IL-8 expression at the level of gene transcription and this effect occurred through a mechanism requiring intracellular calcium and calmodulin activation.	Calcium	136-143	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
10543746-9	1999	These findings indicate that EM is capable of inhibiting expression of the IL-8 gene in T cells through transcriptional inhibition and that this inhibition is mediated through a non-calcineurin-dependent signaling event in T lymphocytes.	Erythromycin	29-31	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
10553845-8	1999	The increases in IL-8 and interferon gamma were 1.5-3 times greater during isoflurane than propofol anesthesia.	Isoflurane	75-85	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
10553845-8	1999	The increases in IL-8 and interferon gamma were 1.5-3 times greater during isoflurane than propofol anesthesia.	Propofol	91-99	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
10589757-0	1999	Discovery of differentially expressed genes associated with paclitaxel resistance using cDNA array technology: analysis of interleukin (IL) 6, IL-8, and monocyte chemotactic protein 1 in the paclitaxel-resistant phenotype.	Paclitaxel	60-70	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
10589757-0	1999	Discovery of differentially expressed genes associated with paclitaxel resistance using cDNA array technology: analysis of interleukin (IL) 6, IL-8, and monocyte chemotactic protein 1 in the paclitaxel-resistant phenotype.	Paclitaxel	191-201	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
10589791-5	1999	Immunohistochemical analysis of tumor lesions indicated that IL-8 overexpression was predominant in the regions surrounding necrotic areas, where cells were exposed to low oxygen tension (hypoxia) and acidic pH.	Oxygen	172-178	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
10589791-9	1999	Decreased IL-8 expression after transfection with IL-8 antisense oligonucleotide expression vector retarded the growth of FG cells in mice after intrapancreatic implantation, which correlated with decreased tumor angiogenesis.	Oligonucleotides	65-80	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
10589791-9	1999	Decreased IL-8 expression after transfection with IL-8 antisense oligonucleotide expression vector retarded the growth of FG cells in mice after intrapancreatic implantation, which correlated with decreased tumor angiogenesis.	Oligonucleotides	65-80	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
10643587-6	1999	IL-8-induced inhibition was blocked partially by the protein kinase C (PKC) inhibitors, sphingosine, and H-7 1-(5-isoquinoline sulfonyl)-2-methylpiperazine.	Sphingosine	88-99	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10596701-10	1999	BOS patients had significantly higher mean levels of MPO, ECP and IL-8 compared to patients without BOS, irrespective of acute rejection status.	N-[4-(Aminosulfonyl)phenyl]-2-Mercaptobenzamide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
10602388-0	1999	Fluoride-induced interleukin-6 and interleukin-8 synthesis in human epithelial lung cells.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	35-48
10602388-4	1999	Dose-response experiments showed a maximal release of IL-6 and IL-8 at a concentration of 5 mM NaF 24 h after addition.	Sodium Fluoride	95-98	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
10602388-6	1999	Time-course experiments showed a NaF-induced IL-6 response at 5 h, whereas an IL-8 response was observed after 10 h. Cycloheximide treatment completely abolished the NaF-induced cytokine responses.	Cycloheximide	117-130	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
10602388-6	1999	Time-course experiments showed a NaF-induced IL-6 response at 5 h, whereas an IL-8 response was observed after 10 h. Cycloheximide treatment completely abolished the NaF-induced cytokine responses.	Sodium Fluoride	166-169	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
10602388-8	1999	The fluoride-induced effects on IL-6 and IL-8 release were strongly reduced by pretreatment with deferoxamine (an Al3+-chelator), and enhanced by addition of Al3+.	Fluorides	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
10602388-8	1999	The fluoride-induced effects on IL-6 and IL-8 release were strongly reduced by pretreatment with deferoxamine (an Al3+-chelator), and enhanced by addition of Al3+.	Deferoxamine	97-109	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
10602388-8	1999	The fluoride-induced effects on IL-6 and IL-8 release were strongly reduced by pretreatment with deferoxamine (an Al3+-chelator), and enhanced by addition of Al3+.	ALUMINUM ION	114-118	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
10602388-8	1999	The fluoride-induced effects on IL-6 and IL-8 release were strongly reduced by pretreatment with deferoxamine (an Al3+-chelator), and enhanced by addition of Al3+.	ALUMINUM ION	158-162	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
10602388-9	1999	This indicates that an AlF4-- complex, a known activator of GTP-binding proteins, is involved in fluoride-induced IL-6 and IL-8 responses in A549 cells.	Guanosine Triphosphate	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
10602388-9	1999	This indicates that an AlF4-- complex, a known activator of GTP-binding proteins, is involved in fluoride-induced IL-6 and IL-8 responses in A549 cells.	Fluorides	97-105	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
10571725-9	1999	Thalidomide did, however, induce a 2-4-fold increase in keratinocyte-derived interleukin-8, a pro-migratory cellular autocrine factor.	Thalidomide	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	77-90
10568711-3	1999	PMN respond to both interleukin-8 and bacterial stimuli with calcium ([Ca2+]i) fluxes, which can initiate respiratory burst (RB).	Calcium	61-68	C-X-C motif chemokine ligand 8	Homo sapiens	20-33
10576211-4	1999	The IL-8-guided migration through an imitation of inflammatory matrix, a fibrin gel, was impaired by 90% after treatment with 7 microM U0126, a specific inhibitor of the kinase of p44/42 kinase.	U 0126	135-140	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
10583443-12	1999	Anti-PR-3 antibody induced endothelial IL-8 expression could be inhibited by cycloheximide.	Cycloheximide	77-90	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
10531258-10	1999	Use of the specific p38/RK inhibitor SB202190 showed that blocking of this pathway results in decreased Stx-mediated IL-8 secretion.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
10592469-9	1999	IL-8 production was significantly inhibited by N-acetyl-L-cysteine, FK506 and MG-132, inhibitors of NF-kappaB activation and translocation.	Acetylcysteine	47-66	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10592469-9	1999	IL-8 production was significantly inhibited by N-acetyl-L-cysteine, FK506 and MG-132, inhibitors of NF-kappaB activation and translocation.	Tacrolimus	68-73	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10592469-9	1999	IL-8 production was significantly inhibited by N-acetyl-L-cysteine, FK506 and MG-132, inhibitors of NF-kappaB activation and translocation.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	78-84	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10528206-7	1999	In addition, decreased IL-8 priming of H2O2 production by PMN from RPP patients could account for a lower bactericidal capacity of PMN, leading to the large number of bacteria in the subgingival region of RPP patients.	Hydrogen Peroxide	39-43	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
10602303-1	1999	This study examined the applicability of luminol-dependent chemiluminescence (CL) response of neutrophils to assess the degree of stress of spinal surgery by measuring the capacity of circulating neutrophils to produce reactive oxygen species and the levels of serum cytokines: interleukin(IL)-1beta, IL-6, IL-8, tumour necrosis factor (TNF)-alpha and granulocyte colony stimulating factor (G-CSF).	Luminol	41-48	C-X-C motif chemokine ligand 8	Homo sapiens	307-311
10643587-6	1999	IL-8-induced inhibition was blocked partially by the protein kinase C (PKC) inhibitors, sphingosine, and H-7 1-(5-isoquinoline sulfonyl)-2-methylpiperazine.	h-7 1-(5-isoquinoline sulfonyl)-2-methylpiperazine	105-155	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10643587-8	1999	CONCLUSION: IL-8 may increase the PAF concentration in the decidua via its inhibitory effect on PAF-AH secretion by decidual macrophages.	Platelet Activating Factor	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
10521501-0	1999	Arsenite exposure of cultured airway epithelial cells activates kappaB-dependent interleukin-8 gene expression in the absence of nuclear factor-kappaB nuclear translocation.	arsenite	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
10593592-0	1999	Sulfur mustard upregulates the expression of interleukin-8 in cultured human keratinocytes.	Mustard Gas	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	45-58
10593592-5	1999	After 6 h, a significantly higher amount of IL-8 was secreted by human keratinocytes treated with 10(-4) M SM and the accumulation of the cytokine persisted up to 24 h after exposure.	Mustard Gas	107-109	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
10598072-5	1999	In vitro chemotaxis of peripheral blood neutrophils to human C5a and ovine IL-8 was increased by dexamethasone treatment.	Dexamethasone	97-110	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
10521501-3	1999	We compared intracellular signaling mediating IL-8 gene expression in bronchial epithelial cells cultured in vitro and exposed to two inducers of cellular stress, sodium arsenite (As(III)), and vanadyl sulfate (V(IV)).	sodium arsenite	163-178	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
10521501-4	1999	Unstimulated bronchial epithelial cells expressed IL-8, and exposure to both metal compounds significantly enhanced IL-8 expression.	Metals	77-82	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
10521501-5	1999	Overexpression of a dominant negative inhibitor of NF-kappaB depressed both basal and metal-induced IL-8 expression.	Metals	86-91	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
10520061-9	1999	MPO and IL-8 were abundantly present in the sputum of all the TDI-induced asthmatic subjects and they increased significantly at 420 min after the bronchial challenges (P = 0.02, P = 0.03, respectively), while no significant changes were noted in group II subjects (P &gt; 0.05).	Toluene 2,4-Diisocyanate	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	8-12
10573218-9	1999	Procaterol inhibited the release of RANTES, GM-CSF and IL-8 in a dose-dependent fashion.	Procaterol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
10614715-8	1999	MTX + EtOH increased the release of IL 6, IL 8 and TNF alpha by 1.0, 1.2, and 1.1 times, respectively.	Methotrexate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
10614715-8	1999	MTX + EtOH increased the release of IL 6, IL 8 and TNF alpha by 1.0, 1.2, and 1.1 times, respectively.	Ethanol	6-10	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
10540334-2	1999	Exposure of U937 cells to etoposide (VP-16) or the nitric oxide (NO) donor DETA-NO, both inducers of apoptosis in these cells, was associated with increased expression of the chemokines IL-8 and macrophage inflammatory protein-1 alpha.	Etoposide	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
10540334-2	1999	Exposure of U937 cells to etoposide (VP-16) or the nitric oxide (NO) donor DETA-NO, both inducers of apoptosis in these cells, was associated with increased expression of the chemokines IL-8 and macrophage inflammatory protein-1 alpha.	Nitric Oxide	51-63	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
10540334-2	1999	Exposure of U937 cells to etoposide (VP-16) or the nitric oxide (NO) donor DETA-NO, both inducers of apoptosis in these cells, was associated with increased expression of the chemokines IL-8 and macrophage inflammatory protein-1 alpha.	DETA-NO	75-82	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
10540334-3	1999	Up-regulation of IL-8 mRNA expression by VP-16 or DETA-NO was observed as early as 4 h or 6 h, respectively, after onset of treatment and was still detectable after 19 h of exposure.	DETA-NO	50-57	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
10540334-5	1999	Moreover, we observed that incubation with 2-chlorodeoxyadenosine (CdA) up-regulated release of IL-8 from adherent PBMC in parallel to induction of apoptosis.	Cladribine	43-65	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
10540334-5	1999	Moreover, we observed that incubation with 2-chlorodeoxyadenosine (CdA) up-regulated release of IL-8 from adherent PBMC in parallel to induction of apoptosis.	Cladribine	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
10540334-7	1999	In addition, CdA augmented release of IL-8 from whole blood cultures.	Cladribine	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
10540155-6	1999	In the intestinal epithelial cell lines HT-29, T84 and Caco-2, sodium butyrate enhanced TNF-alpha-induced C3 secretion, but suppressed TNF-alpha-induced factor B and IL-8 secretion.	Butyric Acid	63-78	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
10551153-10	1999	GM-CSF (50 IU/ml) also significantly increased IL-8 production from 2-7 days of treatment of THP-1 cells when supplemented with a positive control, phorbol-12-myristate-13 acetate (PMA), as compared to PMA treatment alone.	Tetradecanoylphorbol Acetate	148-179	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
10537260-10	1999	The stimulation of IL-8 release was 4-fold (3-fold titanium particles) and of TNF-alpha.	Titanium	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
10537260-13	1999	Rotation per se as well as exposure to increasing concentrations of PE and titanium particles stimulates cytokine release (TNF-alpha, IL-1beta, IL-8) by macrophages in vitro.	Polyethylene	68-70	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
10537260-13	1999	Rotation per se as well as exposure to increasing concentrations of PE and titanium particles stimulates cytokine release (TNF-alpha, IL-1beta, IL-8) by macrophages in vitro.	Titanium	75-83	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
10509360-0	1999	Mechanism for dexamethasone inhibition of neutrophil migration upon exposure to lipopolysaccharide in vitro: role of neutrophil interleukin-8 release.	Dexamethasone	14-27	C-X-C motif chemokine ligand 8	Homo sapiens	128-141
10504268-3	1999	Chemokines bind to glycosaminoglycans on human umbilical vein endothelial cells (HUVECs) with affinities in the micromolar range: RANTES &gt; MCP-1 &gt; IL-8 &gt; MIP-1alpha.	Glycosaminoglycans	19-37	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
10509360-9	1999	At 18 h, media-induced migration activity was decreased if DEX (10(-7) M), IL-8 antibody, or DEX (10(-7) M) with IL-8 antibody were present during the incubation with LPS: there was an 88, 86, and 101% reduction in migration activity, respectively.	Dexamethasone	93-96	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
10509360-10	1999	We conclude that DEX inhibits PMN-induced PMN migration, predominantly via inhibition of IL-8 release for PMNs of the newborn.	Dexamethasone	17-20	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
10948710-8	1999	Chemotaxis induced by fMLP and IL-8 was diminished when blood cells were incubated earlier with 50 mg of nadroparine.	Nadroparin	105-116	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
10520180-3	1999	The chemotaxis of freshly isolated human granulocytes and differentiated HL-60 cells in response to the bacterial tripeptide, f-met-leu-phe, was inhibited in the presence of a physiological concentration of Hp, but chemotaxis in the presence of the proinflammatory cytokine interleukin-8 (IL-8) was not inhibited.	tripeptide K-26	114-124	C-X-C motif chemokine ligand 8	Homo sapiens	274-287
10520180-3	1999	The chemotaxis of freshly isolated human granulocytes and differentiated HL-60 cells in response to the bacterial tripeptide, f-met-leu-phe, was inhibited in the presence of a physiological concentration of Hp, but chemotaxis in the presence of the proinflammatory cytokine interleukin-8 (IL-8) was not inhibited.	tripeptide K-26	114-124	C-X-C motif chemokine ligand 8	Homo sapiens	289-293
10520180-3	1999	The chemotaxis of freshly isolated human granulocytes and differentiated HL-60 cells in response to the bacterial tripeptide, f-met-leu-phe, was inhibited in the presence of a physiological concentration of Hp, but chemotaxis in the presence of the proinflammatory cytokine interleukin-8 (IL-8) was not inhibited.	N-Formylmethionine Leucyl-Phenylalanine	126-139	C-X-C motif chemokine ligand 8	Homo sapiens	274-287
10520180-3	1999	The chemotaxis of freshly isolated human granulocytes and differentiated HL-60 cells in response to the bacterial tripeptide, f-met-leu-phe, was inhibited in the presence of a physiological concentration of Hp, but chemotaxis in the presence of the proinflammatory cytokine interleukin-8 (IL-8) was not inhibited.	N-Formylmethionine Leucyl-Phenylalanine	126-139	C-X-C motif chemokine ligand 8	Homo sapiens	289-293
10504268-8	1999	Isothermal titration calorimetry data confirm these results; IL-8 binds heparin fragments with a K(d) of 0.39-2.63 microM, and requires five saccharide units to bind each monomer of chemokine.	Heparin	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
10504268-8	1999	Isothermal titration calorimetry data confirm these results; IL-8 binds heparin fragments with a K(d) of 0.39-2.63 microM, and requires five saccharide units to bind each monomer of chemokine.	Carbohydrates	141-151	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
10504268-10	1999	Consistent with this, heparin and heparin sulfate could inhibit IL-8-induced neutrophil calcium flux.	Heparin	22-29	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
10504268-10	1999	Consistent with this, heparin and heparin sulfate could inhibit IL-8-induced neutrophil calcium flux.	Heparitin Sulfate	34-49	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
10504268-10	1999	Consistent with this, heparin and heparin sulfate could inhibit IL-8-induced neutrophil calcium flux.	Calcium	88-95	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
10471323-4	1999	Incubation in vitro with jarastatin significantly inhibited, in a concentration-dependent manner, the chemotaxis of human neutrophils toward fMLP, IL-8, and jarastatin itself.	jarastatin	25-35	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
10484459-3	1999	We now show that E1A-dependent induction of interleukin-8 expression is specific to LPS, superinduced by cycloheximide, and not observed after tumor necrosis factor or phorbol 12-myristate 13-acetate stimulation.	Cycloheximide	105-118	C-X-C motif chemokine ligand 8	Homo sapiens	44-57
10477716-3	1999	In this study, we investigate the role of TNFalpha-inducible reactive oxygen species (ROS) in IL-8 expression by "monocyte-like" U937 histiocytic lymphoma cells.	Reactive Oxygen Species	61-84	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
10477716-3	1999	In this study, we investigate the role of TNFalpha-inducible reactive oxygen species (ROS) in IL-8 expression by "monocyte-like" U937 histiocytic lymphoma cells.	Reactive Oxygen Species	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
17030330-1	1999	The nature of the contracted form of poly(methacrylic acid) PMA chain in salt-free acidic aqueous solution was studied by analyzing scattering curves registered by small-angle X-ray scattering, comparing it with those of PMA in methanol at 26 degrees C and of partially neutralized PMA in aqueous solution containing added salt (the concentration of added salt, Cs=0.1 M NaF).	poly(methacrylic acid) pma	37-63	C-X-C motif chemokine ligand 8	Homo sapiens	371-374
11207549-1	1999	Using human endothelial cells, we define a mechanism that accounts for the induction of interleukin 8 (IL-8) by protein I/IIf, an adhesin from Streptococcus mutans serotype f. We report that protein I/IIf interactions with endothelial cells increased the tyrosine phosphorylation of three cellular components with relative mass of 145,000, 125,000 and 70,000 in endothelial cells.	Tyrosine	255-263	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
10475301-9	1999	In this study, we demonstrated that ketamine directly inhibits the production of proinflammatory cytokines such as TNF-alpha, IL-6, and IL-8 in human whole blood.	Ketamine	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
10475301-10	1999	IMPLICATIONS: We found that ketamine suppressed lipopolysaccharide-induced tumor necrosis factor alpha, interleukin (IL)-6, and IL-8 production and recombinant human tumor necrosis factor-induced IL-6 and IL-8 production in human whole blood.	Ketamine	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
10475301-10	1999	IMPLICATIONS: We found that ketamine suppressed lipopolysaccharide-induced tumor necrosis factor alpha, interleukin (IL)-6, and IL-8 production and recombinant human tumor necrosis factor-induced IL-6 and IL-8 production in human whole blood.	Ketamine	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	205-209
10625945-4	1999	An increase in IL-8 secretion by stimulated cells occurred in the presence of IP6.	Phytic Acid	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
10513809-11	1999	SP inhibited cytokine-stimulated HMVEC expression of IL-8 and MCP-1 (P&lt;0.05; [n = 4]).	Sulfapyridine	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
10513809-13	1999	CONCLUSION: These results demonstrate that SSZ and its metabolite SP may affect the pathogenesis of RA by inhibiting EC chemotaxis, proliferation, tube formation, and expression of sICAM-1, IL-8, and MCP-1.	Sulfasalazine	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
10513809-13	1999	CONCLUSION: These results demonstrate that SSZ and its metabolite SP may affect the pathogenesis of RA by inhibiting EC chemotaxis, proliferation, tube formation, and expression of sICAM-1, IL-8, and MCP-1.	Sulfapyridine	66-68	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
10475301-8	1999	At concentrations &gt;100 microg/mL, ketamine also significantly suppressed both LPS-induced and rhTNF-induced IL-6 and IL-8 production.	Ketamine	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
11207549-1	1999	Using human endothelial cells, we define a mechanism that accounts for the induction of interleukin 8 (IL-8) by protein I/IIf, an adhesin from Streptococcus mutans serotype f. We report that protein I/IIf interactions with endothelial cells increased the tyrosine phosphorylation of three cellular components with relative mass of 145,000, 125,000 and 70,000 in endothelial cells.	Tyrosine	255-263	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
10425270-5	1999	In contrast, the pro-inflammatory cytokine TNFalpha, whose activity is dependent on the generation of intracellular ROS, induces IL-8 and ICAM-1 in both cell types.	Reactive Oxygen Species	116-119	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
10464065-9	1999	The short-chain fatty acids, acetate, propionate, butyrate and valerate, the activator of protein kinase C (phorbol-12-myristate-13-acetate) and tumour necrosis factor-alpha (TNF-alpha) all stimulated the secretion of IL-8.	Tetradecanoylphorbol Acetate	108-139	C-X-C motif chemokine ligand 8	Homo sapiens	218-222
10487957-10	1999	IL-8 RNA level correlated with corneal fluorescein staining (rho 0.690, P = 0.001) and conjunctival goblet cell density (rho -0.767, P &lt; 0.001).	Fluorescein	39-50	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10425270-6	1999	The differential induction of IL-8 and ICAM-1 by H2O2 and TNFalpha suggest that the two inflammatory stimuli target distinct redox responsive signaling pathways to activate cell type-specific gene expression.	Hydrogen Peroxide	49-53	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
10425270-1	1999	Reactive oxygen species (ROS), generated either extracellularly or intracellularly through ligand-receptor interactions, can function as signal transduction molecules to activate the chemotactic cytokine interleukin-8 (IL-8) and the cell surface adhesion protein, intercellular adhesion molecule-1 (ICAM-1; CD54).	Reactive Oxygen Species	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	204-217
10425270-1	1999	Reactive oxygen species (ROS), generated either extracellularly or intracellularly through ligand-receptor interactions, can function as signal transduction molecules to activate the chemotactic cytokine interleukin-8 (IL-8) and the cell surface adhesion protein, intercellular adhesion molecule-1 (ICAM-1; CD54).	Reactive Oxygen Species	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	219-223
10483900-10	1999	In the in vitro experiment, sodium butyrate dose-dependently inhibited tumor necrosis factor (TNF)-alpha-induced IL-8 secretion in HT-29 cells.	Butyric Acid	28-43	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
10425270-1	1999	Reactive oxygen species (ROS), generated either extracellularly or intracellularly through ligand-receptor interactions, can function as signal transduction molecules to activate the chemotactic cytokine interleukin-8 (IL-8) and the cell surface adhesion protein, intercellular adhesion molecule-1 (ICAM-1; CD54).	Reactive Oxygen Species	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	204-217
10425270-1	1999	Reactive oxygen species (ROS), generated either extracellularly or intracellularly through ligand-receptor interactions, can function as signal transduction molecules to activate the chemotactic cytokine interleukin-8 (IL-8) and the cell surface adhesion protein, intercellular adhesion molecule-1 (ICAM-1; CD54).	Reactive Oxygen Species	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	219-223
10425270-3	1999	Recent results demonstrate that oxidant stress generated directly by exogenous H2O2 differentially induce IL-8 and ICAM-1 transcription in epithelial and endothelial cells.	Hydrogen Peroxide	79-83	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
10425270-4	1999	H2O2 induces IL-8 but not ICAM-1 in the A549 type-II-like epithelial cell line, whereas in a microvessel endothelial cell line (HMEC-1) as well as in primary endothelial cells, H2O2 induces ICAM-1 but not IL-8, which is spontaneously expressed.	Hydrogen Peroxide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
10425270-4	1999	H2O2 induces IL-8 but not ICAM-1 in the A549 type-II-like epithelial cell line, whereas in a microvessel endothelial cell line (HMEC-1) as well as in primary endothelial cells, H2O2 induces ICAM-1 but not IL-8, which is spontaneously expressed.	Hydrogen Peroxide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	205-209
10469049-8	1999	In contrast, LPMC released IL-8 (650 +/- 125 pg/ml) and IL-10 (75 +/- 25 pg/ml) in response to LPS.	lpmc	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
10469768-8	1999	RESULTS: At the first suspicion of NBI, the combination of IL-8 &gt;/= 53 pg/mL and/or CRP &gt;10 mg/L detected culture-proven NBI with 96% sensitivity.	2-Nitro-N-Phenylbenzamide	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
10551904-3	1999	We hypothesized that butyrate may alter IL-8 and MCP-1 expression by intestinal epithelial cells through histone acetylation.	Butyrates	21-29	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
10551904-9	1999	In contrast, butyrate increased IL-8 production.	Butyrates	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
10497395-4	1999	Reactive oxygen intermediates induce some cytokine gene expression such as IL-8.	reactive oxygen	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
10438951-5	1999	The present study shows that the synthetic glucocorticoid, dexamethasone, inhibits the induction of the proinflammatory cytokine IL-8 and the adhesion molecules VCAM-1 and ICAM-1 in human 1321N1 astrocytoma and SK.N.SH neuroblastoma cells.	Dexamethasone	59-72	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
10438717-4	1999	IL-8 mRNA expression is blocked by the protein kinase C inhibitor bisindolylmaleimide or protein tyrosine kinase inhibitors, genestein and geldanamycin, establishing the involvement of the protein kinase C and protein tyrosine kinase pathways in the activation process.	bisindolylmaleimide	66-85	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10438717-4	1999	IL-8 mRNA expression is blocked by the protein kinase C inhibitor bisindolylmaleimide or protein tyrosine kinase inhibitors, genestein and geldanamycin, establishing the involvement of the protein kinase C and protein tyrosine kinase pathways in the activation process.	geldanamycin	139-151	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10423406-4	1999	MBP stimulated 2-fold increases in IL-8 messenger RNA (mRNA) after 1 and 3 h of incubation, which were blocked by pretreatment with actinomycin D.	Dactinomycin	132-145	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
10423413-10	1999	Although HBECs required stimulation by both CSE and C5a to release maximal levels of IL-8, preincubation of CSE-stimulated HBECs with calphostin C inhibited IL-8 release by CSE + C5a.	calphostin C	134-146	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
10433940-0	1999	Genistein inhibits constitutive and inducible NFkappaB activation and decreases IL-8 production by human cystic fibrosis bronchial gland cells.	Genistein	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
10433940-4	1999	We also demonstrated that the isoflavone genistein, a well known CFTR mutant Cl(-) channel stimulator, significantly reduces the endogenous and Pseudomonas aeruginosa lipopolysaccharide-induced IL-8 production in cultured CF bronchial gland cells by increasing cytosolic IkappaBalpha protein levels.	Isoflavones	30-40	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
10423413-10	1999	Although HBECs required stimulation by both CSE and C5a to release maximal levels of IL-8, preincubation of CSE-stimulated HBECs with calphostin C inhibited IL-8 release by CSE + C5a.	calphostin C	134-146	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
10433940-4	1999	We also demonstrated that the isoflavone genistein, a well known CFTR mutant Cl(-) channel stimulator, significantly reduces the endogenous and Pseudomonas aeruginosa lipopolysaccharide-induced IL-8 production in cultured CF bronchial gland cells by increasing cytosolic IkappaBalpha protein levels.	Genistein	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
10433808-3	1999	We have investigated the effects of 5 lipid mediators (PAF, PGE(2), LTB(4), 12-HETE and 15-HETE) on the spontaneous and cytokine-induced IL-8 synthesis by human bone marrow stromal cells.	Platelet Activating Factor	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
10433940-6	1999	This strong inhibition of constitutively activated NFkappaB and the resulting down-regulation of IL-8 production by genistein in the CF gland cells highlights the key role played by cytosolic IkappaBalpha in the regulation of inflammatory processes in CF human airway cells.	Genistein	116-125	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
10433808-3	1999	We have investigated the effects of 5 lipid mediators (PAF, PGE(2), LTB(4), 12-HETE and 15-HETE) on the spontaneous and cytokine-induced IL-8 synthesis by human bone marrow stromal cells.	Prostaglandins E	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
10433808-3	1999	We have investigated the effects of 5 lipid mediators (PAF, PGE(2), LTB(4), 12-HETE and 15-HETE) on the spontaneous and cytokine-induced IL-8 synthesis by human bone marrow stromal cells.	Leukotriene B4	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
10433808-5	1999	By using a specific ELISA, we found that the production of IL-8 by marrow stromal cells is enhanced after stimulation with 12-HETE (1 microM) both in serum-free and serum-containing culture medium.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	123-130	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
10433808-8	1999	PGE(2)(1 microM or 10 nM) reduces marrow stromal cell IL-8 synthesis in response to IL-1alpha or TNF-alpha.	Dinoprostone	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
10417153-5	1999	Further studies with the L5F11 cell line showed that IL-8 gene transcription induced by H. pylori was blocked by the protein tyrosine kinase inhibitor herbimycin A but not by the protein kinase C inhibitor calphostin C or by the protein kinase G inhibitor KT5823.	herbimycin	151-163	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
10485423-16	1999	However, significantly lower interleukin 8 release and complement activation can be achieved by heparin coating.	Heparin	96-103	C-X-C motif chemokine ligand 8	Homo sapiens	29-42
10457157-7	1999	Co-incubation of MSG with mannan or beta-glucan decreased IL-8 release by 48% and 42% respectively, suggesting that MSG stimulates A549 cells in part through carbohydrate moieties.	Mannans	26-32	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
10457157-7	1999	Co-incubation of MSG with mannan or beta-glucan decreased IL-8 release by 48% and 42% respectively, suggesting that MSG stimulates A549 cells in part through carbohydrate moieties.	beta-Glucans	36-47	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
10457157-8	1999	Dexamethasone significantly inhibited MSG-induced IL-8 release in concentrations of 10-6-10-8 mol L-1 compared with control experiments (P &lt; 0.01).	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
10417153-5	1999	Further studies with the L5F11 cell line showed that IL-8 gene transcription induced by H. pylori was blocked by the protein tyrosine kinase inhibitor herbimycin A but not by the protein kinase C inhibitor calphostin C or by the protein kinase G inhibitor KT5823.	KT 5823	256-262	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
10417209-3	1999	Lipoarabinomannan induced IL-8, MCP-1, and MIP-1beta in vitro, which was partly inhibited by anti-tumor necrosis factor antibody.	lipoarabinomannan	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
10457212-5	1999	There were highly significant intercorrelations among milk Na/K ratio and concentrations of IL-8 and TGF-beta, the last only after treatment with bile salts which also improved TGF-beta recovery in the enzyme-linked immunosorbent assay (ELISA).	Bile Acids and Salts	146-156	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
10457212-7	1999	Dietary supplementation with vitamin E-rich sunflower oil but not provitamin A-containing red palm oil decreased milk Na/K, IL-8 and TGF-beta at 3 months postpartum; however, the effect was significant only for Na/K ratio.	Vitamin E	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
10453373-0	1999	Transdermal nicotine decreases mucosal IL-8 expression but has no effect on mucin gene expression in ulcerative colitis.	Nicotine	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
10634174-7	1999	IL-8 induced a rapid increase of PBG (7-12-fold the basal values).	pbg	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10453373-9	1999	IL-8 mRNA levels were significantly decreased in the colonic mucosa of nicotine-treated patients who improved (p = 0.04).	Nicotine	71-79	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10453373-10	1999	IL-8 mRNA values were similar before and after treatment in nonresponding nicotine-treated patients and in all placebo-treated patients.	Nicotine	74-82	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10453373-12	1999	Beneficial effects of transdermal nicotine in active UC may result from decrease of IL-8 expression at the transcriptional level.	Nicotine	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
10462040-3	1999	IL-8 induction by TNF-alpha was redox sensitive, as indicated by electron spin resonance analysis and inhibition with membrane permeable hydroxyl scavengers.	Hydroxyl Radical	137-145	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10565558-6	1999	After budesonide treatment, the correlation between IL-8 and neutrophils remained, and a correlation between IL-8 and eosinophils emerged.	Budesonide	6-16	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
10565558-6	1999	After budesonide treatment, the correlation between IL-8 and neutrophils remained, and a correlation between IL-8 and eosinophils emerged.	Budesonide	6-16	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
10565558-9	1999	It is possible that neutrophils, through the release of IL-8, could be chemotactic for eosinophils in steroid-treated patients.	Steroids	102-109	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
10442524-7	1999	The steroids only partially inhibited IL-8 release from alveolar macrophages.	Steroids	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
10383461-7	1999	Importantly, the genes for TNF-alpha, IL-8, and MHC class II, but not ICAM-1 or MHC class I, contain cyclic AMP response element (CRE) consensus motifs.	Cyclic AMP	101-111	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
10455891-5	1999	RESULTS: Priming by tumor necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8), and granulocyte-macrophage colony-stimulating factor (GM-CSF) was significantly inhibited by SB203580, whereas platelet-activating factor (PAF) priming was unaffected.	SB 203580	176-184	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
11671064-5	1999	Extended refluxing of TpRe(O)I(2) with an excess of NaF in acetonitrile in the air gives a modest yield of an unusual rhenium &amp;mgr;-pyrazolyl &amp;mgr;-oxo dimer, {[kappa(2)-H(F)Bpz(2)]Re(O)}(2)(&amp;mgr;-pz)(2)(&amp;mgr;-O) (5) (pz = pyrazolyl).	acetonitrile	59-71	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
11671064-5	1999	Extended refluxing of TpRe(O)I(2) with an excess of NaF in acetonitrile in the air gives a modest yield of an unusual rhenium &amp;mgr;-pyrazolyl &amp;mgr;-oxo dimer, {[kappa(2)-H(F)Bpz(2)]Re(O)}(2)(&amp;mgr;-pz)(2)(&amp;mgr;-O) (5) (pz = pyrazolyl).	Adenosine Monophosphate	127-130	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
11671064-5	1999	Extended refluxing of TpRe(O)I(2) with an excess of NaF in acetonitrile in the air gives a modest yield of an unusual rhenium &amp;mgr;-pyrazolyl &amp;mgr;-oxo dimer, {[kappa(2)-H(F)Bpz(2)]Re(O)}(2)(&amp;mgr;-pz)(2)(&amp;mgr;-O) (5) (pz = pyrazolyl).	pyrazolyl	136-145	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
11671064-5	1999	Extended refluxing of TpRe(O)I(2) with an excess of NaF in acetonitrile in the air gives a modest yield of an unusual rhenium &amp;mgr;-pyrazolyl &amp;mgr;-oxo dimer, {[kappa(2)-H(F)Bpz(2)]Re(O)}(2)(&amp;mgr;-pz)(2)(&amp;mgr;-O) (5) (pz = pyrazolyl).	Adenosine Monophosphate	147-150	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
11671064-5	1999	Extended refluxing of TpRe(O)I(2) with an excess of NaF in acetonitrile in the air gives a modest yield of an unusual rhenium &amp;mgr;-pyrazolyl &amp;mgr;-oxo dimer, {[kappa(2)-H(F)Bpz(2)]Re(O)}(2)(&amp;mgr;-pz)(2)(&amp;mgr;-O) (5) (pz = pyrazolyl).	bpz	182-185	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
11671064-5	1999	Extended refluxing of TpRe(O)I(2) with an excess of NaF in acetonitrile in the air gives a modest yield of an unusual rhenium &amp;mgr;-pyrazolyl &amp;mgr;-oxo dimer, {[kappa(2)-H(F)Bpz(2)]Re(O)}(2)(&amp;mgr;-pz)(2)(&amp;mgr;-O) (5) (pz = pyrazolyl).	Adenosine Monophosphate	147-150	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
11671064-5	1999	Extended refluxing of TpRe(O)I(2) with an excess of NaF in acetonitrile in the air gives a modest yield of an unusual rhenium &amp;mgr;-pyrazolyl &amp;mgr;-oxo dimer, {[kappa(2)-H(F)Bpz(2)]Re(O)}(2)(&amp;mgr;-pz)(2)(&amp;mgr;-O) (5) (pz = pyrazolyl).	Adenosine Monophosphate	147-150	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
11671064-5	1999	Extended refluxing of TpRe(O)I(2) with an excess of NaF in acetonitrile in the air gives a modest yield of an unusual rhenium &amp;mgr;-pyrazolyl &amp;mgr;-oxo dimer, {[kappa(2)-H(F)Bpz(2)]Re(O)}(2)(&amp;mgr;-pz)(2)(&amp;mgr;-O) (5) (pz = pyrazolyl).	pyrazolyl	239-248	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
10442524-10	1999	In conclusion, budesonide and fluticasone propionate, in concentrations that probably occur in the airway lining fluid during inhalational therapy, inhibited cytokine release from human lung epithelial cells (IL-6, IL-8) and alveolar macrophages (TNF-alpha, IL-6, IL-8).	Budesonide	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
10442524-10	1999	In conclusion, budesonide and fluticasone propionate, in concentrations that probably occur in the airway lining fluid during inhalational therapy, inhibited cytokine release from human lung epithelial cells (IL-6, IL-8) and alveolar macrophages (TNF-alpha, IL-6, IL-8).	Budesonide	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	264-268
10442524-10	1999	In conclusion, budesonide and fluticasone propionate, in concentrations that probably occur in the airway lining fluid during inhalational therapy, inhibited cytokine release from human lung epithelial cells (IL-6, IL-8) and alveolar macrophages (TNF-alpha, IL-6, IL-8).	Fluticasone	30-52	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
10442524-10	1999	In conclusion, budesonide and fluticasone propionate, in concentrations that probably occur in the airway lining fluid during inhalational therapy, inhibited cytokine release from human lung epithelial cells (IL-6, IL-8) and alveolar macrophages (TNF-alpha, IL-6, IL-8).	Fluticasone	30-52	C-X-C motif chemokine ligand 8	Homo sapiens	264-268
10414449-5	1999	Our results have shown that ATRA induces an increased expression of IL-8, IL-1beta, TNF-alpha and ICAM-1 in APL cells, which can be amplified by the addition of G-CSF.	Tretinoin	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
10391852-6	1999	In addition, proinflammatory cytokine (interleukin 1beta [IL-1beta] and tumor necrosis factor alpha [TNF-alpha]) levels are greater in culture wells containing discs of polyolefin polymer than in those containing discs of polyvinyl chloride polymer with the TEHTM plasticizer, and even more so in storage bags containing polyolefin polymer versus polyvinyl chloride polymer with the TEHTM plasticizer (IL-1beta, TNF-alpha, IL-6, and IL-8).	polyolefin polymer	169-187	C-X-C motif chemokine ligand 8	Homo sapiens	433-437
10456399-10	1999	The TCA group had significantly higher levels of IL-6 (P = 0.001), IL-8 (P = 0.005) and S100B (P = 0.002) at 24 h. C5b-9 levels were significantly lower in the TCA group: end of CPB (P = 0.001), 30 min (P &lt; 0.001), 2 h (P = 0.002).	Trichloroacetic Acid	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
10489835-0	1999	Thiol regulation of the production of TNF-alpha, IL-6 and IL-8 by human alveolar macrophages.	Sulfhydryl Compounds	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
10456399-13	1999	CONCLUSIONS: (1) The TCA group have prolonged rises of IL-6, IL-8 and S100B.	Trichloroacetic Acid	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
10489835-4	1999	Depletion of intracellular GSH by treatment with buthionine sulphoximine (BSO) reached 45.2% after 3 h and was nearly complete at 24 h. Whereas a 24-h preincubation of AMs with BSO significantly increased LPS-induced secretion of TNF-alpha and IL-8, a 3-h preincubation only enhanced LPS-stimulated production of IL-8 (p&lt;0.05).	Glutathione	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	244-248
10353855-5	1999	Compared with placebo, rimantadine treatment reduced viral shedding, systemic symptoms, and levels of IL-8.	Rimantadine	23-34	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
10489835-4	1999	Depletion of intracellular GSH by treatment with buthionine sulphoximine (BSO) reached 45.2% after 3 h and was nearly complete at 24 h. Whereas a 24-h preincubation of AMs with BSO significantly increased LPS-induced secretion of TNF-alpha and IL-8, a 3-h preincubation only enhanced LPS-stimulated production of IL-8 (p&lt;0.05).	Glutathione	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	313-317
10489835-4	1999	Depletion of intracellular GSH by treatment with buthionine sulphoximine (BSO) reached 45.2% after 3 h and was nearly complete at 24 h. Whereas a 24-h preincubation of AMs with BSO significantly increased LPS-induced secretion of TNF-alpha and IL-8, a 3-h preincubation only enhanced LPS-stimulated production of IL-8 (p&lt;0.05).	Buthionine Sulfoximine	49-72	C-X-C motif chemokine ligand 8	Homo sapiens	244-248
10489835-4	1999	Depletion of intracellular GSH by treatment with buthionine sulphoximine (BSO) reached 45.2% after 3 h and was nearly complete at 24 h. Whereas a 24-h preincubation of AMs with BSO significantly increased LPS-induced secretion of TNF-alpha and IL-8, a 3-h preincubation only enhanced LPS-stimulated production of IL-8 (p&lt;0.05).	Buthionine Sulfoximine	49-72	C-X-C motif chemokine ligand 8	Homo sapiens	313-317
10489835-4	1999	Depletion of intracellular GSH by treatment with buthionine sulphoximine (BSO) reached 45.2% after 3 h and was nearly complete at 24 h. Whereas a 24-h preincubation of AMs with BSO significantly increased LPS-induced secretion of TNF-alpha and IL-8, a 3-h preincubation only enhanced LPS-stimulated production of IL-8 (p&lt;0.05).	Buthionine Sulfoximine	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	244-248
10489835-4	1999	Depletion of intracellular GSH by treatment with buthionine sulphoximine (BSO) reached 45.2% after 3 h and was nearly complete at 24 h. Whereas a 24-h preincubation of AMs with BSO significantly increased LPS-induced secretion of TNF-alpha and IL-8, a 3-h preincubation only enhanced LPS-stimulated production of IL-8 (p&lt;0.05).	Buthionine Sulfoximine	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	313-317
10489835-6	1999	Addition of GSH and NAC significantly reduced the secretion of TNF-alpha (mean+/-SEM 21.2+/-5 and 44.7+/-4.4% inhibition, respectively) as well as LPS-induced IL-6 and IL-8 (p&lt;0.05).	Glutathione	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
10489835-6	1999	Addition of GSH and NAC significantly reduced the secretion of TNF-alpha (mean+/-SEM 21.2+/-5 and 44.7+/-4.4% inhibition, respectively) as well as LPS-induced IL-6 and IL-8 (p&lt;0.05).	Acetylcysteine	20-23	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
10489835-7	1999	Similarly, NAC inhibited the production of TNF-alpha, IL-6 and IL-8 in GSH-depleted AMs obtained by BSO pretreatment.	Acetylcysteine	11-14	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
10489835-7	1999	Similarly, NAC inhibited the production of TNF-alpha, IL-6 and IL-8 in GSH-depleted AMs obtained by BSO pretreatment.	Glutathione	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
10489835-8	1999	In conclusion, N-acetylcysteine and glutathione inhibit the production of tumour necrosis factor-alpha, interleukin-8 and interleukin-6 by alveolar macrophages by a mechanism independent of glutathione metabolism.	Acetylcysteine	15-31	C-X-C motif chemokine ligand 8	Homo sapiens	104-117
10489835-8	1999	In conclusion, N-acetylcysteine and glutathione inhibit the production of tumour necrosis factor-alpha, interleukin-8 and interleukin-6 by alveolar macrophages by a mechanism independent of glutathione metabolism.	Glutathione	36-47	C-X-C motif chemokine ligand 8	Homo sapiens	104-117
10489835-9	1999	However, total depletion of glutathione within alveolar macrophages significantly increases tumour necrosis factor-alpha and interleukin-8 synthesis whereas it does not modulate interleukin-6 secretion.	Glutathione	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	125-138
10400845-6	1999	NO2 also significantly increased the release of IL-8 from a control value of 52.5 pg/microgram cellular protein to 81.9 pg/microgram cellular protein (P &lt;.05), RANTES from a control value of 0.023 pg/microgram cellular protein to 0.062 pg/microgram cellular protein (P &lt;.05), and sICAM-1 from a control value of 7.7 pg/microgram cellular protein to 16.3 pg/microgram cellular protein (P &lt;.05).	Nitrogen Dioxide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
10404837-6	1999	Midluteal endometrium showed minimal IL-8 expression, whereas endometrium obtained from women administered progesterone for 4 days from (LH peak + 8 days), to simulate luteal regression, demonstrated significantly increased localization of IL-8 mRNA, 48 h after withdrawal of progesterone.	Progesterone	107-119	C-X-C motif chemokine ligand 8	Homo sapiens	240-244
10412778-0	1999	Rapid normalization of interleukin-8 production after low-density lipoprotein apheresis in steroid-resistant nephrotic syndrome.	Steroids	91-98	C-X-C motif chemokine ligand 8	Homo sapiens	23-36
10398759-7	1999	Preincubation of SR with NaF and ATP, but not with NaF and AMP-PNP caused strong inhibition of ryanodine binding.	Ryanodine	95-104	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
10412778-8	1999	IL-8 production by lipopolysaccharide (LPS)-stimulated PBMC, mainly adherent cells, was significantly reduced in both the steroid-resistant FGS group and nontreated NS group compared with controls, but TNF-alpha production was reduced in the only FGS group.	Steroids	122-129	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10412778-10	1999	CONCLUSION: Significant amelioration of IL-8 production independent of any effect of steroids on LPS-stimulated PBMCs may reflect a beneficial effect of LDL-A in normalizing the function of circulating monocytes in steroid-resistant FGS.	ldl-a	153-158	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
10463330-4	1999	IL-8, which activates a CXC receptor coupled to PTX-sensitive G proteins, induced at 10 nM an enhanced maximum chemotaxis of neutrophils from individuals with TC/TT genotype compared to CC genotype.	Technetium	159-161	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10381841-6	1999	In this study, we set out to investigate a potential linkage between the generation of ROS and production of IL8 in alpha-particle-irradiated normal human lung fibroblasts.	Reactive Oxygen Species	87-90	C-X-C motif chemokine ligand 8	Homo sapiens	109-112
16801094-1	1999	We found that nafamostat mesilate (NM) inhibits platelet aggregation induced by all agonists tested, including ADP, collagen, arachidonic acid, thromboxane A analog, A23187, phorbol 12-myristate 13-acetate (PMA), NaF and thrombin.	nafamostat	14-33	C-X-C motif chemokine ligand 8	Homo sapiens	213-216
10381841-9	1999	Cells exposed to alpha particles in the presence of antioxidants, i.e. superoxide dismutase and dimethyl sulfoxide, resulted in significant decreases in extracellular IL8 protein levels.	Dimethyl Sulfoxide	96-114	C-X-C motif chemokine ligand 8	Homo sapiens	167-170
10381841-11	1999	Our results indicate that alpha-particle-induced increases in production of IL8 occur temporally in parallel with elevated production of ROS.	Reactive Oxygen Species	137-140	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
10358198-8	1999	LPS-induced IL-8 and TNF-alpha production was inhibited in a similar pattern by pretreatment with either EtOH or SB202190 (1 microM), a specific inhibitor of p38 kinase.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	113-121	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
10418175-7	1999	Serum IL-8 levels decreased gradually with abstinence from alcohol.	Alcohols	59-66	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
10353264-0	1999	Up-regulation of interleukin-1beta-stimulated interleukin-8 in human keratinocytes by nitric oxide.	Nitric Oxide	86-98	C-X-C motif chemokine ligand 8	Homo sapiens	46-59
10353264-3	1999	Incubation with the NO donor S-nitroso-N-acetylpenicillamine (SNAP) for 24 hr increased IL-8 protein only in HaCaT cells, partly due to the presence of constitutive interleukin-1 (IL-1).	S-Nitroso-N-Acetylpenicillamine	29-60	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
10353264-3	1999	Incubation with the NO donor S-nitroso-N-acetylpenicillamine (SNAP) for 24 hr increased IL-8 protein only in HaCaT cells, partly due to the presence of constitutive interleukin-1 (IL-1).	S-Nitroso-N-Acetylpenicillamine	62-66	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
10466876-0	1999	Effect of an aluminum hydroxide-magnesium hydroxide combination drug on adhesion, IL-8 inducibility, and expression of HSP60 by Helicobacter pylori.	Aluminum Hydroxide	13-31	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
10466876-0	1999	Effect of an aluminum hydroxide-magnesium hydroxide combination drug on adhesion, IL-8 inducibility, and expression of HSP60 by Helicobacter pylori.	Magnesium Hydroxide	32-51	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
10466876-8	1999	IL-8 secretion from MKN45 cells after H. pylori infection was also inhibited by co-magaldrox.	aluminum hydroxide, magnesium hydroxide, drug combination	80-92	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
10466876-10	1999	HSP60-induced IL-8 secretion was significantly inhibited by co-magaldrox in a dose-dependent manner.	aluminum hydroxide, magnesium hydroxide, drug combination	60-72	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
10466876-11	1999	CONCLUSIONS: These results show that co-magaldrox suppressed the expression of the following virulence factors: adhesion, IL-8 inducibility, and expression of extracellular HSP60.	aluminum hydroxide, magnesium hydroxide, drug combination	37-49	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
10358198-0	1999	Alcohol (ethanol) inhibits IL-8 and TNF: role of the p38 pathway.	Alcohols	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	27-39
10358198-0	1999	Alcohol (ethanol) inhibits IL-8 and TNF: role of the p38 pathway.	Ethanol	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	27-39
10358198-12	1999	Inhibition of IL-8 and TNF-alpha production by acute EtOH intoxication may inhibit inflammatory focused neutrophil migration and activation and may be a mechanism explaining the increased risk of trauma- and burn-related infections.	Ethanol	53-57	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
10358198-8	1999	LPS-induced IL-8 and TNF-alpha production was inhibited in a similar pattern by pretreatment with either EtOH or SB202190 (1 microM), a specific inhibitor of p38 kinase.	Ethanol	105-109	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
10445612-2	1999	To this end, the phosphorylation and activation of p38 MAP kinase and the effect of SB 203580, a specific inhibitor of p38 MAP kinase activity, on p38 MAP kinase activity and IL-8 expression in TNF-alpha- and IL-1alpha-stimulated human pulmonary vascular endothelial cells were examined.	SB 203580	84-93	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
10357776-4	1999	Butyrate-induced expression of carcinoembryonic antigen and interleukin-8, dome formation and cell turnover were also markedly augmented by pre-treatment with phorbol myristate acetate.	Butyrates	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	60-73
10357776-4	1999	Butyrate-induced expression of carcinoembryonic antigen and interleukin-8, dome formation and cell turnover were also markedly augmented by pre-treatment with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	159-184	C-X-C motif chemokine ligand 8	Homo sapiens	60-73
10348816-0	1999	Helicobacter pylori-dependent ceramide production may mediate increased interleukin 8 expression in human gastric cancer cell lines.	Ceramides	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	72-85
10348816-2	1999	Because several studies have shown that sphingolipids are involved in a number of signaling pathways, including NF-kappaB activation, we investigated the possible role of sphingolipids in the regulation of IL-8 expression in Kato III and AGS cells.	Sphingolipids	171-184	C-X-C motif chemokine ligand 8	Homo sapiens	206-210
10387004-0	1999	Disulfide bridges in interleukin-8 probed using non-natural disulfide analogues: dissociation of roles in structure from function.	Disulfides	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	21-34
10387004-0	1999	Disulfide bridges in interleukin-8 probed using non-natural disulfide analogues: dissociation of roles in structure from function.	Disulfides	60-69	C-X-C motif chemokine ligand 8	Homo sapiens	21-34
10387004-1	1999	The structural and functional roles of the two disulfide bridges in interleukin-8 (IL-8) were addressed using IL-8 analogues with covalently modified disulfide bridges.	Disulfides	47-56	C-X-C motif chemokine ligand 8	Homo sapiens	68-81
10387004-1	1999	The structural and functional roles of the two disulfide bridges in interleukin-8 (IL-8) were addressed using IL-8 analogues with covalently modified disulfide bridges.	Disulfides	47-56	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
10387004-1	1999	The structural and functional roles of the two disulfide bridges in interleukin-8 (IL-8) were addressed using IL-8 analogues with covalently modified disulfide bridges.	Disulfides	150-159	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
10387004-1	1999	The structural and functional roles of the two disulfide bridges in interleukin-8 (IL-8) were addressed using IL-8 analogues with covalently modified disulfide bridges.	Disulfides	150-159	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
10387004-6	1999	Modification to the disulfide bridge between cysteines 9 and 50 had only a modest effect on IL-8 function.	Disulfides	20-29	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
10387004-6	1999	Modification to the disulfide bridge between cysteines 9 and 50 had only a modest effect on IL-8 function.	Cysteine	45-54	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
10362718-11	1999	Immunoreactive leukotriene B4 receptor, interleukin-8, granulocyte colony-stimulating factor, and monocyte chemoattractant protein-1 significantly increased in supernatant fluids in response to bleomycin.	Bleomycin	194-203	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
10333502-3	1999	However, fluoride ion (1 M NaF) causes a 1000-fold activation of the mutant enzyme while simultaneously inhibiting WT activity by 20-fold in the forward reaction.	Fluorides	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
10401557-8	1999	Moreover, rolipram significantly potentiated hyperalgesia induced by carrageenan, bradykinin, TNF alpha, IL-1 beta, IL-6 and IL-8.	Rolipram	10-18	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
10401557-15	1999	The ODQ potentiated hyperalgesia induced by carrageenan, bradykinin, TNF alpha, IL-1 beta, IL-6 and IL-8.	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
10445614-8	1999	In conclusion, interleukin-8, neutrophil elastase and leukotriene B4 contribute to the neutrophilic inflammation in the airways of chronic lower respiratory tract infection patients and the clinical effects of roxithromycin may, in part, be attributable to the suppression of excess release of the chemotactic mediators from inflammatory cells.	Roxithromycin	210-223	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
10348816-7	1999	RESULTS: A cell-permeable ceramide analogue (C2-ceramide) increased IL-8 expression with comparable mRNA induction.	Ceramides	26-34	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
10348816-7	1999	RESULTS: A cell-permeable ceramide analogue (C2-ceramide) increased IL-8 expression with comparable mRNA induction.	N-acetylsphingosine	45-56	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
10348816-8	1999	This effect was mimicked by sphingomyelinase, but not by phospholipase A2 or phospholipase C. C2-ceramide induced IL-8 gene transcription mainly through activation of NF-kappaB because mutation of the NF-kappaB-binding site completely abrogated the induction of luciferase activity.	N-acetylsphingosine	94-105	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
10348816-10	1999	CONCLUSIONS: The results suggest a novel role of the sphingomyelin-ceramide pathway, at least in part through NF-kappaB, in IL-8 production induced by H. pylori infection in gastric epithelial cells.	Sphingomyelins	53-66	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
10348816-10	1999	CONCLUSIONS: The results suggest a novel role of the sphingomyelin-ceramide pathway, at least in part through NF-kappaB, in IL-8 production induced by H. pylori infection in gastric epithelial cells.	Ceramides	67-75	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
10445612-4	1999	Inhibition of TNF-alpha- and IL-1alpha-induced p38 MAP kinase activity by SB 203580 inhibited TNF-alpha- and IL-1alpha-induced IL-8 protein production as well as IL-8 messenger ribonucleic acid (mRNA) expression, indicating that SB 203580 was effective at the transcriptional level.	SB 203580	74-83	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
10424432-4	1999	PD98059, an inhibitor of MAP kinase kinase (MEK), inhibited IL-6, IL-8 and basic FGF production in HS and all cytokines production except basic FGF in SW982.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
10424432-7	1999	Rolipram or R0201724, an inhibitor of cyclic AMP-specific PDE, inhibited IL-8 and basic FGF production in HS and TNFalpha production in SW982, however, it enhanced the other cytokines production in SW982.	Cyclic AMP	38-48	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
10392761-6	1999	(S)- and (R)-ibuprofen were equal in their inhibitory/activating effects on cytokine production, with the exception of stronger IL-8 induction in endothelial cells by (R)-ibuprofen as compared to its chiral analogue.	Ibuprofen	167-180	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
10359894-10	1999	Moreover, supernatants from DEP-PAH-activated cells, compared with those of controls, exhibited a significantly enhanced chemotactic activity for neutrophils and eosinophils, which was significantly inhibited by pretreatment with anti-IL-8 and anti-RANTES neutralizing antibodies, respectively.	p-Aminohippuric Acid	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	235-239
10437657-0	1999	Inducer-specific bidirectional regulation of endothelial interleukin-8 production by thalidomide.	Thalidomide	85-96	C-X-C motif chemokine ligand 8	Homo sapiens	57-70
10454826-10	1999	Calcium mobilization experiments revealed minimal inhibition of the IL-8-induced increase in calcium after pretreatment with TNFalpha, but the response to NAP-2 was substantially inhibited.	Calcium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
10341002-4	1999	We also evaluated the mRNA expression for IL-6 and IL-8 in ESC after C-PAF stimulation using Northern blot analysis.	1-O-hexadecyl-2-N-methylcarbamol -sn-glycerol-3-phosphocholine	69-74	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
10454826-10	1999	Calcium mobilization experiments revealed minimal inhibition of the IL-8-induced increase in calcium after pretreatment with TNFalpha, but the response to NAP-2 was substantially inhibited.	Calcium	93-100	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
10226072-8	1999	Furthermore, we found significant increases in the release of IL-4, IL-6, IL-8, and TNF-alpha of ozone-exposed (0.1 ppm) samples of atopic versus nonatopic patients and to a lesser extent for histamine following exposure to 0.15 ppm ozone.	Ozone	97-102	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
10216072-2	1999	Only a subgroup of CXC chemokines defined by the conserved sequence motif glutamic acid-leucine-arginine (ELR) tripeptide motif, which included interleukin-8 (IL-8), growth-regulated oncogene alpha (GROalpha), neutrophil-activating peptide-2 (NAP-2), and epithelial cell-derived neutrophil activating peptide-78 (ENA-78), induced calcium flux in the cells.	elr	106-109	C-X-C motif chemokine ligand 8	Homo sapiens	144-157
10216072-2	1999	Only a subgroup of CXC chemokines defined by the conserved sequence motif glutamic acid-leucine-arginine (ELR) tripeptide motif, which included interleukin-8 (IL-8), growth-regulated oncogene alpha (GROalpha), neutrophil-activating peptide-2 (NAP-2), and epithelial cell-derived neutrophil activating peptide-78 (ENA-78), induced calcium flux in the cells.	tripeptide K-26	111-121	C-X-C motif chemokine ligand 8	Homo sapiens	144-157
10225834-3	1999	In contrast, PMNLs from the HIV and HIV/TB groups responded reciprocally in the same assay; that is, higher IL-8 input concentrations resulted in the release of less enzyme than lower IL-8 input concentrations.	Terbium	40-42	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
10225834-3	1999	In contrast, PMNLs from the HIV and HIV/TB groups responded reciprocally in the same assay; that is, higher IL-8 input concentrations resulted in the release of less enzyme than lower IL-8 input concentrations.	Terbium	40-42	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
10328874-4	1999	In addition, sodium salicylate and additional NSAIDs used at concentrations that activate HSF1 also inhibited the expression of other monocytic genes (TNF-alpha, IL-1beta, IL-6, IL-8, IL-10, ICAM-1) activated by exposure to a pro-inflammatory stimulus (lipopolysaccharide, LPS).	Sodium Salicylate	13-30	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
10229865-13	1999	The concentrations of IL-8, G-CSF, monocyte chemoattractant protein-1, GM-CSF, and TGF-beta in the supernatant fluids significantly increased in response to bleomycin.	Bleomycin	157-166	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
10326962-4	1999	RESULTS: Antazoline hydrochloride, emedastine difumarate, levocabastine hydrochloride, olopatadine hydrochloride, and pheniramine maleate attenuated histamine-stimulated phosphatidylinositol turnover and IL-6 and IL-8 secretion.	Olopatadine Hydrochloride	87-112	C-X-C motif chemokine ligand 8	Homo sapiens	213-217
10326962-4	1999	RESULTS: Antazoline hydrochloride, emedastine difumarate, levocabastine hydrochloride, olopatadine hydrochloride, and pheniramine maleate attenuated histamine-stimulated phosphatidylinositol turnover and IL-6 and IL-8 secretion.	Pheniramine	118-137	C-X-C motif chemokine ligand 8	Homo sapiens	213-217
10326962-4	1999	RESULTS: Antazoline hydrochloride, emedastine difumarate, levocabastine hydrochloride, olopatadine hydrochloride, and pheniramine maleate attenuated histamine-stimulated phosphatidylinositol turnover and IL-6 and IL-8 secretion.	Histamine	149-158	C-X-C motif chemokine ligand 8	Homo sapiens	213-217
10226715-1	1999	AIMS: The study aims to directly measure uptake of Na and F ions by glass ionomer cement from dilute NaF solution and compare this with the subsequent re-release of these ions into water.	Fluorine	58-59	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
10226715-14	1999	CONCLUSIONS: Glass ionomer cements take up Na and F ions from NaF solution in large quantities and in equimolar proportion.	Fluorine	50-51	C-X-C motif chemokine ligand 8	Homo sapiens	62-65
10362412-0	1999	Effect of the nitric oxide inhibitor, L-N(G)-monomethylarginine, on accumulation of interleukin-6 and interleukin-8, and nuclear factor-kappaB activity in a human endothelial cell line.	Nitric Oxide	14-26	C-X-C motif chemokine ligand 8	Homo sapiens	102-115
10362412-0	1999	Effect of the nitric oxide inhibitor, L-N(G)-monomethylarginine, on accumulation of interleukin-6 and interleukin-8, and nuclear factor-kappaB activity in a human endothelial cell line.	l-n(g)-monomethylarginine	38-63	C-X-C motif chemokine ligand 8	Homo sapiens	102-115
10362412-7	1999	IL-6 accumulation was decreased (p &lt; .05) and IL-8 accumulation increased (p &lt; .01) with L-NMMA.	N(G)-monomethylarginine acetate	95-101	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
10437388-5	1999	Histamine increases IL-8 level and evokes leukocyte rolling on endothelial cells.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
10329835-0	1999	Elevated levels of IL-8 in interstitial pneumonia induced by low-dose methotrexate.	Methotrexate	70-82	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
10325294-1	1999	Hyaluronic acid (HA) stimulates the synthesis of interleukin (IL) 8, while dehydroepiandrosterone sulphate (DHEA-S) induces the expression of IL-8 and its receptor in the human cervical fibroblast.	Hyaluronic Acid	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	49-67
10325294-1	1999	Hyaluronic acid (HA) stimulates the synthesis of interleukin (IL) 8, while dehydroepiandrosterone sulphate (DHEA-S) induces the expression of IL-8 and its receptor in the human cervical fibroblast.	Hyaluronic Acid	17-19	C-X-C motif chemokine ligand 8	Homo sapiens	49-67
10325294-1	1999	Hyaluronic acid (HA) stimulates the synthesis of interleukin (IL) 8, while dehydroepiandrosterone sulphate (DHEA-S) induces the expression of IL-8 and its receptor in the human cervical fibroblast.	Dehydroepiandrosterone Sulfate	75-106	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
10227335-0	1999	Grain dust induces IL-8 production from bronchial epithelial cells: the effect of dexamethasone on IL-8 production.	Dexamethasone	82-95	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
10202011-7	1999	Finally, both N-acetylcysteine and pyrrolidine dithiocarbamate attenuated the action of DEP on IL-8 mRNA expression, suggesting that oxidant-mediated pathway might be involved in its processes.	Acetylcysteine	14-30	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
10202011-7	1999	Finally, both N-acetylcysteine and pyrrolidine dithiocarbamate attenuated the action of DEP on IL-8 mRNA expression, suggesting that oxidant-mediated pathway might be involved in its processes.	pyrrolidine dithiocarbamic acid	35-62	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
10369130-0	1999	Thrombin-induced interleukin-8 production and its regulation by interferon-gamma and prostaglandin E2 in human monocytic U937 cells.	Dinoprostone	85-101	C-X-C motif chemokine ligand 8	Homo sapiens	17-30
10369130-6	1999	Moreover, thrombin-induced IL-8 production by U937 cells was differentially regulated by interferon (IFN)-gamma and prostaglandin (PG)E2.	Dinoprostone	116-136	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
10103183-7	1999	Among these agents, imipenem demonstrated rapid killing of P. aeruginosa as well as rapid release of PNR and resulted in the highest IL-8 production.	Imipenem	20-28	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
10103183-9	1999	The immunoprecipitates of the aliquots of bacterial culture containing imipenem or complement with anti-PNR immunoglobulin G (IgG) induced twofold-higher IL-8 production than did the immunoprecipitates of the aliquots of bacterial culture with a control IgG.	Imipenem	71-79	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
10103198-3	1999	We studied the effect of erythromycin, clarithromycin, josamycin, and other antibiotics on the release by eosinophils of interleukin-8 (IL-8), a potent chemokine for inflammatory cells, including eosinophils themselves.	Erythromycin	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	121-134
10227335-8	1999	RESULTS: There was significant production of IL-8 from bronchial epithelial cells with additions of GD in a dose-dependent manner (P &lt; .05), which was significantly augmented with additions of PBMC supernatant (P &lt; .05) at each concentration.	Gadolinium	100-102	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
10103198-3	1999	We studied the effect of erythromycin, clarithromycin, josamycin, and other antibiotics on the release by eosinophils of interleukin-8 (IL-8), a potent chemokine for inflammatory cells, including eosinophils themselves.	Erythromycin	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
10103198-3	1999	We studied the effect of erythromycin, clarithromycin, josamycin, and other antibiotics on the release by eosinophils of interleukin-8 (IL-8), a potent chemokine for inflammatory cells, including eosinophils themselves.	Clarithromycin	39-53	C-X-C motif chemokine ligand 8	Homo sapiens	121-134
10227335-9	1999	Compared with the untreated sample, pretreatment of dexamethasone could induced a remarkable inhibitions (15% to 55%) of IL-8 production from bronchial epithelial cells in a dose-dependent manner.	Dexamethasone	52-65	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
10103198-3	1999	We studied the effect of erythromycin, clarithromycin, josamycin, and other antibiotics on the release by eosinophils of interleukin-8 (IL-8), a potent chemokine for inflammatory cells, including eosinophils themselves.	Clarithromycin	39-53	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
10227335-10	1999	CONCLUSION: These results suggest that IL-8 production from bronchial epithelial cells may contribute to neutrophil recruitment occurring in GD-induced airway inflammation.	Gadolinium	141-143	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
10103198-3	1999	We studied the effect of erythromycin, clarithromycin, josamycin, and other antibiotics on the release by eosinophils of interleukin-8 (IL-8), a potent chemokine for inflammatory cells, including eosinophils themselves.	Josamycin	55-64	C-X-C motif chemokine ligand 8	Homo sapiens	121-134
10103198-3	1999	We studied the effect of erythromycin, clarithromycin, josamycin, and other antibiotics on the release by eosinophils of interleukin-8 (IL-8), a potent chemokine for inflammatory cells, including eosinophils themselves.	Josamycin	55-64	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
10227335-11	1999	The downregulation of IL-8 production by dexamethasone from bronchial epithelial cells may contribute to the efficacy of this compound in reducing cellular infiltration and ultimately to its anti-inflammatory property.	Dexamethasone	41-54	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
10103198-5	1999	Only 14-member macrolides (erythromycin and clarithromycin) showed a concentration-dependent suppressive effect on IL-8 release (control, 100%; erythromycin at 1 microgram/ml, 67.82% +/- 3.45% [P &lt; 0.01]; clarithromycin at 5 micrograms/ml, 56.81% +/- 9.61% [P &lt; 0.01]).	Erythromycin	27-39	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
10090924-8	1999	In addition, while treatment of neutrophils with LPS and TNF-alpha inhibited IL-8 receptor-mediated calcium mobilization and IL-8-directed neutrophil chemotaxis, both 1, 10-phenanthroline and EDTA blocked these inhibitory processes.	1,10-phenanthroline	167-187	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
10103198-5	1999	Only 14-member macrolides (erythromycin and clarithromycin) showed a concentration-dependent suppressive effect on IL-8 release (control, 100%; erythromycin at 1 microgram/ml, 67.82% +/- 3.45% [P &lt; 0.01]; clarithromycin at 5 micrograms/ml, 56.81% +/- 9.61% [P &lt; 0.01]).	Clarithromycin	44-58	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
10103198-5	1999	Only 14-member macrolides (erythromycin and clarithromycin) showed a concentration-dependent suppressive effect on IL-8 release (control, 100%; erythromycin at 1 microgram/ml, 67.82% +/- 3.45% [P &lt; 0.01]; clarithromycin at 5 micrograms/ml, 56.81% +/- 9.61% [P &lt; 0.01]).	Erythromycin	144-156	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
10090924-8	1999	In addition, while treatment of neutrophils with LPS and TNF-alpha inhibited IL-8 receptor-mediated calcium mobilization and IL-8-directed neutrophil chemotaxis, both 1, 10-phenanthroline and EDTA blocked these inhibitory processes.	Calcium	100-107	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
10090924-8	1999	In addition, while treatment of neutrophils with LPS and TNF-alpha inhibited IL-8 receptor-mediated calcium mobilization and IL-8-directed neutrophil chemotaxis, both 1, 10-phenanthroline and EDTA blocked these inhibitory processes.	Edetic Acid	192-196	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
10090924-8	1999	In addition, while treatment of neutrophils with LPS and TNF-alpha inhibited IL-8 receptor-mediated calcium mobilization and IL-8-directed neutrophil chemotaxis, both 1, 10-phenanthroline and EDTA blocked these inhibitory processes.	Edetic Acid	192-196	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
10223179-6	1999	In contrast, the cell lines significantly increased alkaline phosphatase activities by &gt;50%, urokinase receptor expression &gt;2-fold and interleukin-8 secretion &gt;3-fold in response to butyrate.	Butyrates	191-199	C-X-C motif chemokine ligand 8	Homo sapiens	141-154
10223179-8	1999	Interleukin-8 secretion increased by 145 +/- 23% and 132 +/- 17% on 24 h exposure to 2 mM butyrate or 0.1 microM TNF alpha alone, respectively.	Butyrates	90-98	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
10101223-6	1999	The membrane spanning heptahelical IL-8 receptor is coupled with the effector enzyme(s) through the intermediacy of heterotrimeric GTP-binding regulatory proteins.	Guanosine Triphosphate	131-134	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
10101223-10	1999	Neutrophils activation of phospholipase D (PLD) and superoxide generation in response to IL-8 have also been demonstrated.	Superoxides	52-62	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
10101223-11	1999	Furthermore, IL-8-mediated activation of mitogen activating protein kinase (MAPK) and tyrosine phosphorylation of cellular proteins have been observed.	Tyrosine	86-94	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
10230950-8	1999	MEASUREMENTS AND MAIN RESULTS: After CPB, the concentration of the proinflammatory cytokines, interleukin-6 and interleukin-8, was significantly less in the methylprednisolone group.	Methylprednisolone	157-175	C-X-C motif chemokine ligand 8	Homo sapiens	112-125
10211881-10	1999	In animals treated with AdvIL-10, the MMP-3-TIMP-1 balance was partially restored, independent of the effect on mRNA expression of tumor necrosis factor a, IL-1, IL-6, or IL-8.	advil-10	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
10084995-5	1999	S. sanguis and S. mutans LTAs at a 1,000-fold excess each completely inhibited the IL-8-inducing activities of both LPS and a synthetic lipid A on CD14(high) HGF.	Lipid A	136-143	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
10101031-11	1999	These results indicate that extracellular adenosine can regulate ERK, c-Jun N-terminal kinase, and p38 MAPK signaling cascades and that activation of ERK and p38 MAPK pathways are essential steps in adenosine A2B receptor-dependent stimulation of IL-8 production in HMC-1.	Adenosine	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	247-251
10329481-0	1999	A potent immunosuppressant FK506 inhibits IL-8 expression in human eosinophils.	Tacrolimus	27-32	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
10329481-3	1999	In the present study, we evaluated if FK506 had any effect on the production of IL-8, one of the important chemokines for a variety of inflammatory cells, from human peripheral eosinophils.	Tacrolimus	38-43	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
10329481-4	1999	Purified eosinophils constitutively released IL-8, which was increased with calcium ionophore (10(-6) M).	Calcium	76-83	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
10329481-5	1999	FK506 showed a dose-dependent suppressive effect on IL-8 production by eosinophils stimulated with calcium ionophore, but showed no effect on unstimulated cells.	Tacrolimus	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
10329481-5	1999	FK506 showed a dose-dependent suppressive effect on IL-8 production by eosinophils stimulated with calcium ionophore, but showed no effect on unstimulated cells.	Calcium	99-106	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
10329481-6	1999	Evaluation of IL-8 mRNA levels by reverse transcription and polymerase chain reaction demonstrated that FK506 suppressed IL-8 gene expression only in activated eosinophils.	Tacrolimus	104-109	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
10329481-6	1999	Evaluation of IL-8 mRNA levels by reverse transcription and polymerase chain reaction demonstrated that FK506 suppressed IL-8 gene expression only in activated eosinophils.	Tacrolimus	104-109	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
10101031-4	1999	The mechanism by which adenosine promotes IL-8 synthesis has not been defined.	Adenosine	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
10076137-0	1999	The action of prostaglandin E2 on the human cervix: stimulation of interleukin 8 and inhibition of secretory leukocyte protease inhibitor.	Dinoprostone	14-30	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
10367558-5	1999	Lithium (10(-3) M) significantly increased the unstimulated production of IL-8 and IL-10.	Lithium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
10367558-6	1999	CONCLUSIONS: The results suggest that lithium has significant immunoregulatory effects by increasing the production of both proinflammatory cytokines (IFNgamma, TNFalpha and IL-8) and negative immunoregulatory cytokines or proteins (IL-10 and the IL-1RA).	Lithium	38-45	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
10363611-15	1999	CONCLUSIONS: The results show a similar reduction of the inflammatory cytokine release (IL-6 and IL-8 as markers) using early steroid application and aprotinin in high dosage.	Steroids	126-133	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
10076137-5	1999	RESULTS: Interleukin 8 release from cervical explants was stimulated by prostaglandin E2 and nitric oxide and inhibited by progesterone and dexamethasone.	Dinoprostone	72-88	C-X-C motif chemokine ligand 8	Homo sapiens	9-22
10076137-5	1999	RESULTS: Interleukin 8 release from cervical explants was stimulated by prostaglandin E2 and nitric oxide and inhibited by progesterone and dexamethasone.	Nitric Oxide	93-105	C-X-C motif chemokine ligand 8	Homo sapiens	9-22
10076137-5	1999	RESULTS: Interleukin 8 release from cervical explants was stimulated by prostaglandin E2 and nitric oxide and inhibited by progesterone and dexamethasone.	Progesterone	123-135	C-X-C motif chemokine ligand 8	Homo sapiens	9-22
10076137-5	1999	RESULTS: Interleukin 8 release from cervical explants was stimulated by prostaglandin E2 and nitric oxide and inhibited by progesterone and dexamethasone.	Dexamethasone	140-153	C-X-C motif chemokine ligand 8	Homo sapiens	9-22
10191034-10	1999	A significant increase of interleukin-8 release could be found after 4 h of rew/reox following storage in EuroCollins solution.	eurocollins	106-117	C-X-C motif chemokine ligand 8	Homo sapiens	26-39
10204985-0	1999	Hydrolysis of alpha-tricalcium phosphate in NaF solutions.	alpha-tricalcium phosphate	14-40	C-X-C motif chemokine ligand 8	Homo sapiens	44-47
10204985-3	1999	Hydrolysis of alpha-tricalcium phosphate (alpha-TCP) was carried out at physiologic temperature in NaF solutions and the solids product(s) were analyzed.	alpha-tricalcium phosphate	14-40	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
10204985-3	1999	Hydrolysis of alpha-tricalcium phosphate (alpha-TCP) was carried out at physiologic temperature in NaF solutions and the solids product(s) were analyzed.	alpha-tricalcium phosphate	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
10204985-7	1999	The extent of fluoride and sodium incorporation in the apatites formed varied depending on the NaF concentration of the solution.	Fluorides	14-22	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
10204985-7	1999	The extent of fluoride and sodium incorporation in the apatites formed varied depending on the NaF concentration of the solution.	Sodium	27-33	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
10342040-1	1999	OBJECTIVES: The aim of this study was to investigate the effects of two nonsteroidal anti-inflammatory drugs (NSAIDs), nimesulide and sodium diclofenac, on the production of proteoglycans (PG), prostaglandin E2 (PGE2) and cytokines (IL-6 and IL-8) by human articular chondrocytes in vitro.	nimesulide	119-129	C-X-C motif chemokine ligand 8	Homo sapiens	242-246
10342040-1	1999	OBJECTIVES: The aim of this study was to investigate the effects of two nonsteroidal anti-inflammatory drugs (NSAIDs), nimesulide and sodium diclofenac, on the production of proteoglycans (PG), prostaglandin E2 (PGE2) and cytokines (IL-6 and IL-8) by human articular chondrocytes in vitro.	Diclofenac	134-151	C-X-C motif chemokine ligand 8	Homo sapiens	242-246
10204985-11	1999	The (Ca+Na)/P ratio of the apatite formed by alpha-TCP hydrolysis in 0.1M NaF approaches 1.67 indicating the vacant Ca sites become almost completely filled by the Na ions.	ca+na	5-10	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
10204985-11	1999	The (Ca+Na)/P ratio of the apatite formed by alpha-TCP hydrolysis in 0.1M NaF approaches 1.67 indicating the vacant Ca sites become almost completely filled by the Na ions.	alpha-tricalcium phosphate	45-54	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
10199534-13	1999	CONCLUSIONS: Methylprednisolone reduces the production of IL-6 and IL-8 but not that of IL-10 and IL-1ra.	Methylprednisolone	13-31	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
10092093-3	1999	Here, we have measured IL-8-induced Ca2+ signals in single human neutrophil granulocytes using the Ca2+ indicator dye FURA-2 AM and we have investigated the signal transduction that leads to these Ca2+ signals with various pharmacological tools.	fura-2-am	118-127	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
10213368-11	1999	Microparticles prepared from either chitosan or starch microparticles, applied apically, induced the basolateral release of IL-6 and IL-8 from polarized Calu-3 cells.	Chitosan	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
10080530-3	1999	Our results demonstrate that H2O2 induction of IL-8 gene expression is linked with the selective binding of AP-1 to the IL-8 promoter, whereas TNF-alpha and RSV induction of IL-8 correlates with the activation of NF-kappaB binding.	Hydrogen Peroxide	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
10080530-3	1999	Our results demonstrate that H2O2 induction of IL-8 gene expression is linked with the selective binding of AP-1 to the IL-8 promoter, whereas TNF-alpha and RSV induction of IL-8 correlates with the activation of NF-kappaB binding.	Hydrogen Peroxide	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
10080530-3	1999	Our results demonstrate that H2O2 induction of IL-8 gene expression is linked with the selective binding of AP-1 to the IL-8 promoter, whereas TNF-alpha and RSV induction of IL-8 correlates with the activation of NF-kappaB binding.	Hydrogen Peroxide	29-33	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
10089966-0	1999	Inhibitory effect of erythromycin on interleukin-8 secretion from exudative cells in the nasal discharge of patients with chronic sinusitis.	Erythromycin	21-33	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
10089966-2	1999	The authors studied the inhibitory effect of erythromycin on interleukin-8 (IL-8) secretion from exudative cells in the nasal discharge of patients with chronic sinusitis.	Erythromycin	45-57	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
10089966-2	1999	The authors studied the inhibitory effect of erythromycin on interleukin-8 (IL-8) secretion from exudative cells in the nasal discharge of patients with chronic sinusitis.	Erythromycin	45-57	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
10089966-6	1999	RESULTS: The amount of secreted IL-8 in the absence of erythromycin was 682 +/- 226 pg/10(6) cells/24 h. The IL-8 secretion was significantly reduced to 66 +/- 15% and 46 +/- 13% of the control in the presence of 10(-6) and 10(-5) M of erythromycin, respectively.	Erythromycin	55-67	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
10089966-6	1999	RESULTS: The amount of secreted IL-8 in the absence of erythromycin was 682 +/- 226 pg/10(6) cells/24 h. The IL-8 secretion was significantly reduced to 66 +/- 15% and 46 +/- 13% of the control in the presence of 10(-6) and 10(-5) M of erythromycin, respectively.	Erythromycin	236-248	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
10089966-7	1999	CONCLUSION: Erythromycin may act as a biologic modulator that inhibits IL-8 secretion from exudative cells and thereby blocks the vicious circle of neutrophil recruitment and IL-8 generation in the inflammatory site in chronic sinusitis.	Erythromycin	12-24	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
10089966-7	1999	CONCLUSION: Erythromycin may act as a biologic modulator that inhibits IL-8 secretion from exudative cells and thereby blocks the vicious circle of neutrophil recruitment and IL-8 generation in the inflammatory site in chronic sinusitis.	Erythromycin	12-24	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
10333355-7	1999	SPF, PGE2 and 19-hydroxy PGE significantly (P&lt; 0.005) stimulated IL-8 release from peripheral blood and U937 cells.	butylparaben	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
10333355-7	1999	SPF, PGE2 and 19-hydroxy PGE significantly (P&lt; 0.005) stimulated IL-8 release from peripheral blood and U937 cells.	Dinoprostone	5-9	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
10333355-7	1999	SPF, PGE2 and 19-hydroxy PGE significantly (P&lt; 0.005) stimulated IL-8 release from peripheral blood and U937 cells.	19-hydroxy pge	14-28	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
10333355-8	1999	19-hydroxy PGE was significantly (P&lt; 0.005) more effective than PGE2 in stimulating IL-8 release.	19-hydroxy pge	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
10333355-8	1999	19-hydroxy PGE was significantly (P&lt; 0.005) more effective than PGE2 in stimulating IL-8 release.	Dinoprostone	67-71	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
10213368-11	1999	Microparticles prepared from either chitosan or starch microparticles, applied apically, induced the basolateral release of IL-6 and IL-8 from polarized Calu-3 cells.	Starch	48-54	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
10050881-0	1999	Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma.	Oxygen	50-56	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
10076615-10	1999	There was a significant negative correlation between the peak serum IL-8 level and the initial velocity of arterial ketone body ratio recovery for the first 5 minutes after reperfusion r = -0.83, P &lt; .001).	Ketones	116-122	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
10050881-9	1999	Since intratumoral augmentation of IL-8 and VEGF secretion, following microenvironmental decreases in oxygen pressure, may promote angiogenesis, further definition of these pathways is essential to appropriately target them for antitumoral therapy.	Oxygen	102-108	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
10368283-9	1999	In this model, the heparin-binding residues of IL-8 are exposed, thereby allowing presentation of the chemokine from endothelial cell-surface glycosaminoglycans.	Heparin	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
10368283-9	1999	In this model, the heparin-binding residues of IL-8 are exposed, thereby allowing presentation of the chemokine from endothelial cell-surface glycosaminoglycans.	Glycosaminoglycans	142-160	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
10063910-6	1999	Externally applied H2O2 significantly up-regulated IL-8 expression.	Hydrogen Peroxide	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
9927384-5	1999	SB 203580 as the specific p38 MAP kinase inhibitor inhibited hyperosmolarity-induced p38 MAP kinase activation and partially inhibited hyperosmolarity-induced IL-8 expression.	SB 203580	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
10048791-0	1999	Formation of phosphatidic acid and subclasses of phosphatidylethanol in human neutrophils upon interleukin-8 stimulation.	Phosphatidic Acids	13-30	C-X-C motif chemokine ligand 8	Homo sapiens	95-108
10048791-0	1999	Formation of phosphatidic acid and subclasses of phosphatidylethanol in human neutrophils upon interleukin-8 stimulation.	phosphatidylethanol	49-68	C-X-C motif chemokine ligand 8	Homo sapiens	95-108
10048791-1	1999	Previous studies showed that interleukin-8 (IL-8) stimulates phospholipase D hydrolysis of phosphatidylcholine to generate phosphatidic acid in human neutrophils.	Phosphatidylcholines	91-110	C-X-C motif chemokine ligand 8	Homo sapiens	29-42
10048791-1	1999	Previous studies showed that interleukin-8 (IL-8) stimulates phospholipase D hydrolysis of phosphatidylcholine to generate phosphatidic acid in human neutrophils.	Phosphatidylcholines	91-110	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
10048791-1	1999	Previous studies showed that interleukin-8 (IL-8) stimulates phospholipase D hydrolysis of phosphatidylcholine to generate phosphatidic acid in human neutrophils.	Phosphatidic Acids	123-140	C-X-C motif chemokine ligand 8	Homo sapiens	29-42
10048791-1	1999	Previous studies showed that interleukin-8 (IL-8) stimulates phospholipase D hydrolysis of phosphatidylcholine to generate phosphatidic acid in human neutrophils.	Phosphatidic Acids	123-140	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
10048791-3	1999	No studies have examined phospholipase D hydrolysis of the three subclasses of phosphatidylcholine in interleukin-8-stimulated neutrophils.	Phosphatidylcholines	79-98	C-X-C motif chemokine ligand 8	Homo sapiens	102-115
10048791-7	1999	Our findings suggest that phospholipase D catalyses the hydrolysis of diacyl, alkylacyl and alkenylacyl subclasses of phosphatidylcholine in neutrophils upon IL-8 stimulation.	Phosphatidylcholines	118-137	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
10063906-0	1999	Helicobacter pylori water extract induces interleukin-8 production by gastric epithelial cells.	Water	20-25	C-X-C motif chemokine ligand 8	Homo sapiens	42-55
10063906-3	1999	The aims of the present study were to determine whether an H. pylori water extract (HPE) induces IL-8 production by gastric epithelial cells and to characterize IL-8-inducing substances in HPE.	Water	69-74	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
10063910-5	1999	N-Acetylcysteine (NAC) or dimethylsulfoxide inhibited IL-8 expression induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta).	Acetylcysteine	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
10063910-5	1999	N-Acetylcysteine (NAC) or dimethylsulfoxide inhibited IL-8 expression induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta).	Acetylcysteine	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
10063910-5	1999	N-Acetylcysteine (NAC) or dimethylsulfoxide inhibited IL-8 expression induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta).	Dimethyl Sulfoxide	26-43	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
9916078-5	1999	By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	221-225
9895238-4	1999	N-acetyl cysteine inhibited RV-induced NF-kappaB activation and IL-8 elaboration.	Acetylcysteine	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
9916078-5	1999	By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions.	SB 203580	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	221-225
10069413-0	1999	Inhibition of IL-6 and IL-8 induction from cultured rheumatoid synovial fibroblasts by treatment with aurothioglucose.	Aurothioglucose	102-117	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
10069413-3	1999	In this study, we examined the effect of one of the monovalent gold compounds, aurothioglucose (AuTG), on the IL-1-induced production of IL-6, IL-8 and granulocyte macrophage colony stimulating factor (GM-CSF) from rheumatoid synovial fibroblasts (RSF) isolated from three RA patients.	Aurothioglucose	79-94	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
10337430-19	1999	(7) have shown that exposure of human conjunctival epithelial cells to histamine leads to the production of pro-inflammatory cytokines IL-6 and IL-8.	Histamine	71-80	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
10069413-4	1999	IL-6 and IL-8 induction but not GM-CSF induction was inhibited in most of the RSF after pretreatment with AuTG.	(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
10069413-4	1999	IL-6 and IL-8 induction but not GM-CSF induction was inhibited in most of the RSF after pretreatment with AuTG.	Aurothioglucose	106-110	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
10380161-7	1999	In the BL, NO2 exposure caused increases in polymorphonuclear neutrophils (PMNs), interleukin 6 (IL-6), IL-8, alpha1-antitrypsin, and tissue plasminogen activator, and decreases in epithelial cells.	Nitrogen Dioxide	11-14	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
9973432-5	1999	In contrast, inhibition of IL-8 and GRO activities using neutralizing Abs resulted in a specific 6-fold increase in PGE2 but not in PGF2alpha production by stimulated microglial cells and astrocytes, whereas Abs to beta-chemokines had no effect.	Dinoprostone	116-120	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
9973432-8	1999	Conversely, the elevated intracerebral alpha-chemokine levels could reduce PG secretion, preventing the exacerbation of inflammation and neurotoxicity.	Prostaglandins	75-77	C-X-C motif chemokine ligand 8	Homo sapiens	39-54
9927048-9	1999	In MM-1 and MM-2 cells, IL-8 caused a dose-dependent increase of [3H]thymidine incorporation to maximal levels of 46.3 +/- 3.6% and 12.3 +/- 1.6% (P &lt; 0.001), respectively, when compared with serum-free medium as control.	Tritium	66-68	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
10022397-6	1999	Compared with controls (IL-6, 1.1 +/- 0.3 ng/L; IL-8, 3.2 +/- 0.8 ng/L), untreated patients with GD and TNG had elevated IL-6 (GD, 7.11 +/- 0.88 ng/L; TNG, 7.30 +/- 0.77 ng/L; P &lt; 0.001) and IL-8 (GD, 10.3 +/- 1.23 ng/L; TNG, 9.81 +/- 1.27 ng/L; P &lt; 0.001).	Nitroglycerin	104-107	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
10022397-8	1999	Thyroid carcinoma patients on TSH suppressive therapy also had significantly raised levels of IL-6 (2.5 +/- 0.42 ng/L) and IL-8 (4.4 +/- 0.63 ng/L).	Thyrotropin	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Tetradecanoylphorbol Acetate	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Tetradecanoylphorbol Acetate	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	248-252
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Ionomycin	108-117	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
9918530-0	1999	Interleukin-8 mediates downregulation of tissue inhibitor of metalloproteinase-1 expression in cholesterol-loaded human macrophages: relevance to stability of atherosclerotic plaque.	Cholesterol	95-106	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
9916736-5	1999	While actinomycin-D (1 microg/ml) had little influence on the generation of IL-8 during chemotaxis, the protein synthesis inhibitor cycloheximide (10 microg/ml) markedly blunted the accumulation of cell-associated IL-8, suggesting that new protein synthesis from preexisting mRNA was responsible for the effect.	Cycloheximide	132-145	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
9916736-6	1999	Consistent with this interpretation, migrating cells incorporated over 10 times as much [3H]leucine into IL-8 as did nonmotile neutrophils exposed to chemoattractants.	Tritium	89-91	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
9916736-6	1999	Consistent with this interpretation, migrating cells incorporated over 10 times as much [3H]leucine into IL-8 as did nonmotile neutrophils exposed to chemoattractants.	Leucine	92-99	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
10483873-8	1999	We also found that fraxiparine was able to significantly increase chemokinesis and decrease chemotaxis in the gradient of both fMLP and IL-8.	Nadroparin	19-30	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
9864200-5	1999	When gentamicin was added to INT407 cells at 2 h after infection with 81-176, IL-8 secretion 22 h later was equivalent to that of controls without gentamicin, suggesting that the events which trigger induction and release of IL-8 occur early in the interactions of bacteria and eukaryotic cells.	Gentamicins	5-15	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
10505790-0	1999	Nitric oxide regulates interleukin-8 gene expression in activated endothelium by inhibiting NF-kappaB binding to DNA: effects on endothelial function.	Nitric Oxide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	23-36
10505790-2	1999	We showed that exogenous nitric oxide in the form of a nitric oxide donor significantly reduced IL-8 mRNA in cytokine-activated ECV304.	Nitric Oxide	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
10505790-2	1999	We showed that exogenous nitric oxide in the form of a nitric oxide donor significantly reduced IL-8 mRNA in cytokine-activated ECV304.	Nitric Oxide	55-67	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
10505790-3	1999	Similarly, nitric oxide significantly reduced migration of polymorphonuclear neutrophils through cytokine-activated ECV304 monolayers, an IL-8-dependent process.	Nitric Oxide	11-23	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
10505790-4	1999	Using a luciferase reporter construct containing the NF-kappaB site of the IL-8 gene, we showed that exposing cytokine-activated ECV304 to exogenous nitric oxide resulted in significant reduction of NF-kappaB binding.	Nitric Oxide	149-161	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
9892783-4	1999	This was tested by measuring the effect of sodium fluoride (NaF) on cytokine production by human whole blood cells stimulated in vitro.	Sodium Fluoride	43-58	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
10051702-11	1999	The amount of IL-8 and GM-CSF, induced by histamine, was significantly higher in DEP extract pretreated HNECs and HMMECs than nontreated HNECs and HMMECs.	Histamine	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
10051702-12	1999	CONCLUSION: These results strongly suggest that DEP accelerates the inflammatory change by not only directly upregulating H1R expression but also increasing histamine-induced IL-8 and GM-CSF production.	Histamine	157-166	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
9864200-5	1999	When gentamicin was added to INT407 cells at 2 h after infection with 81-176, IL-8 secretion 22 h later was equivalent to that of controls without gentamicin, suggesting that the events which trigger induction and release of IL-8 occur early in the interactions of bacteria and eukaryotic cells.	Gentamicins	5-15	C-X-C motif chemokine ligand 8	Homo sapiens	225-229
9950270-8	1999	The present IL-8 dependent and cAMP-regulated augmentation of LPS-induced stimulation of transmigration is the first description of an additive effect of PTX with a pro-inflammatory agent.	Pentoxifylline	154-157	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
10092202-0	1999	Effects of erythromycin and its derivatives on interleukin-8 release by human bronchial epithelial cell line BEAS-2B cells.	Erythromycin	11-23	C-X-C motif chemokine ligand 8	Homo sapiens	47-60
10702726-7	1999	Induction of oxidative stress by H(2)O(2) upregulated IL-8 expression.	Hydrogen Peroxide	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
10702726-9	1999	ISIS 2922 only partially inhibited the upregulation of IL-8 in infected cells treated with H(2)O(2), whereas cotreatment with ISIS 2922 and antioxidants inhibited the upregulation almost completely.	Water	91-96	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
10080106-0	1999	Acute alcohol consumption attenuates interleukin-8 (IL-8) and monocyte chemoattractant peptide-1 (MCP-1) induction in response to ex vivo stimulation.	Alcohols	6-13	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
10080106-0	1999	Acute alcohol consumption attenuates interleukin-8 (IL-8) and monocyte chemoattractant peptide-1 (MCP-1) induction in response to ex vivo stimulation.	Alcohols	6-13	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
9920091-1	1999	The role of progesterone (P4) in the regulation of inflammatory mediators interleukin-8 (IL-8), monocyte chemoattractant protein-1, and cyclooxygenase-2 (COX-2) and in the recruitment of leukocyte subpopulations in the endometrium has been examined, by employing a model of P4 withdrawal and maintenance in vivo.	Progesterone	12-24	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
9920091-1	1999	The role of progesterone (P4) in the regulation of inflammatory mediators interleukin-8 (IL-8), monocyte chemoattractant protein-1, and cyclooxygenase-2 (COX-2) and in the recruitment of leukocyte subpopulations in the endometrium has been examined, by employing a model of P4 withdrawal and maintenance in vivo.	Progesterone	12-24	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
10414594-13	1999	In untreated subjects and in patients receiving NaF, the former fraction contains ionic fluoride.	Fluorides	88-96	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
9932682-10	1999	RESULTS: Postinjury PMNs were primed for both platelet-activating factor/N-formyl-methionyl-leucyl-phenylalanine-stimulated and lipopolysaccharide-stimulated IL-8 and TNF release at 2 hours after injury (fourfold increase of IL-8 release and fivefold increase of TNF release), whereas elective surgical patients demonstrated no priming.	Nitrogen	22-23	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
9862763-3	1999	The increased production of IL-8 and expression of IL-8 mRNA were significantly inhibited by rebamipide (100-1000 microM) in a concentration-dependent manner.	rebamipide	93-103	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
9862763-3	1999	The increased production of IL-8 and expression of IL-8 mRNA were significantly inhibited by rebamipide (100-1000 microM) in a concentration-dependent manner.	rebamipide	93-103	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
9862763-7	1999	It is concluded that rebamipide exerts its preventive effect against H. pylori-evoked gastric mucosal cell inflammation by inhibition of the neutrophil adherence to the endothelial cells as well as by suppressing the surface expression of CD11b on neutrophils and the production of proinflammatory cytokine such as IL-8 from gastric epithelial cells.	rebamipide	21-31	C-X-C motif chemokine ligand 8	Homo sapiens	315-319
9932682-10	1999	RESULTS: Postinjury PMNs were primed for both platelet-activating factor/N-formyl-methionyl-leucyl-phenylalanine-stimulated and lipopolysaccharide-stimulated IL-8 and TNF release at 2 hours after injury (fourfold increase of IL-8 release and fivefold increase of TNF release), whereas elective surgical patients demonstrated no priming.	Nitrogen	22-23	C-X-C motif chemokine ligand 8	Homo sapiens	225-229
9835634-8	1999	These results suggest that inhaled steroids improve airway inflammation and lung function in asthmatics, presumably in part by inhibiting the synthesis of inflammatory cytokines such as IL-8 and GM-CSF.	Steroids	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
12938511-1	1999	The effect of Sinomenine on IL-8, IL-6, IL-2 and mIL-2R produced by peripheral blood mononuclear cells was investigated by using cell culture, radioimmunoassay and flow cytometry.	sinomenine	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
9888410-10	1999	RESULTS: There was a significant decrease in monocyte TNF, IL-8, and IL-6 production after OTZ therapy.	otz	91-94	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
10348705-0	1999	Epinephrine promotes IL-8 production in human leukocytes via an effect on platelets.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
10413893-1	1999	According to previous pharmacokinetic studies the bioavailability of fluorine (F) from sodium monofluorophosphate (MFP) doubles that of sodium fluoride (NaF).	Fluorine	69-77	C-X-C motif chemokine ligand 8	Homo sapiens	153-156
10413893-1	1999	According to previous pharmacokinetic studies the bioavailability of fluorine (F) from sodium monofluorophosphate (MFP) doubles that of sodium fluoride (NaF).	Sodium Fluoride	136-151	C-X-C motif chemokine ligand 8	Homo sapiens	153-156
10440571-1	1999	We investigated the effect of FUT-175, a serine protease inhibitor, on the production of pro-inflammatory cytokines, interleukin-6 (IL-6) and interleukin-8 (IL-8), by monocytes stimulated with lipopolysaccharide (LPS).	nafamostat	30-37	C-X-C motif chemokine ligand 8	Homo sapiens	142-155
10440571-1	1999	We investigated the effect of FUT-175, a serine protease inhibitor, on the production of pro-inflammatory cytokines, interleukin-6 (IL-6) and interleukin-8 (IL-8), by monocytes stimulated with lipopolysaccharide (LPS).	nafamostat	30-37	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
10325585-2	1999	Ethanol (EtOH) may play a role in the pathogenesis of psoriasis by upregulating the expression and inducing the local secretion of proinflammatory cytokines, e.g. interleukins IL-1alpha, IL-6, chemokine IL-8 and tumor necrosis factor alpha (TNF-alpha).	Ethanol	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
10325585-2	1999	Ethanol (EtOH) may play a role in the pathogenesis of psoriasis by upregulating the expression and inducing the local secretion of proinflammatory cytokines, e.g. interleukins IL-1alpha, IL-6, chemokine IL-8 and tumor necrosis factor alpha (TNF-alpha).	Ethanol	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
10051376-5	1999	Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
10051376-5	1999	Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner.	Tetradecanoylphorbol Acetate	89-92	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
10051376-6	1999	These results show that curcumin exhibits an inhibitory effect on the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages.	Curcumin	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
9882597-3	1999	BEAS-2B cells, exposed to residual oil fly ash particles (ROFA), responded with an immediate (&lt;30 s) increase in intracellular calcium levels ([Ca2+]i), increases of key inflammatory cytokine transcripts (i.e., IL-6, IL-8, TNFalpha) within 2 h exposure, and subsequent release of IL-6 and IL-8 cytokine protein after 4 h exposure.	Oils	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	220-224
9882597-3	1999	BEAS-2B cells, exposed to residual oil fly ash particles (ROFA), responded with an immediate (&lt;30 s) increase in intracellular calcium levels ([Ca2+]i), increases of key inflammatory cytokine transcripts (i.e., IL-6, IL-8, TNFalpha) within 2 h exposure, and subsequent release of IL-6 and IL-8 cytokine protein after 4 h exposure.	Oils	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	292-296
9882597-5	1999	However, pretreatment of these cells with capsazepine (CPZ), an antagonist for capsaicin (i.e., vanilloid) receptors, inhibited the immediate increases in [Ca2+]i, diminished transcript (i.e., IL-6, IL-8, TNFalpha) levels and reduced IL-6 cytokine release to control levels.	capsazepine	42-53	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
9882597-5	1999	However, pretreatment of these cells with capsazepine (CPZ), an antagonist for capsaicin (i.e., vanilloid) receptors, inhibited the immediate increases in [Ca2+]i, diminished transcript (i.e., IL-6, IL-8, TNFalpha) levels and reduced IL-6 cytokine release to control levels.	capsazepine	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
9882597-6	1999	BEAS-2B cells exposed to ROFA in calcium-free media failed to demonstrate increases of [Ca2+]i and showed reduced levels of cytokine transcript (i.e., IL-6, IL-8, TNFalpha) and IL-6 release, suggesting that ROFA-stimulated cytokine formation was partially dependent on extracellular calcium sources.	rofa	25-29	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
9882597-6	1999	BEAS-2B cells exposed to ROFA in calcium-free media failed to demonstrate increases of [Ca2+]i and showed reduced levels of cytokine transcript (i.e., IL-6, IL-8, TNFalpha) and IL-6 release, suggesting that ROFA-stimulated cytokine formation was partially dependent on extracellular calcium sources.	Calcium	33-40	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
10563385-1	1999	Earlier we showed that 4-hours treatment of cells K562 with the GTP-binding protein activator AlF4- (10 mM NaF + 20 microM AlCl3) increased the DNA fragmentation on an average to 5% of the total 3H-thymidine-labeled DNA.	Guanosine Triphosphate	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	107-110
10348705-2	1999	Epinephrine has been reported by several groups to suppress activation of monocytes in response to LPS, and the aim of the present study was to examine the effect of epinephrine on LPS induced IL-8 production using whole blood as a model system.	Epinephrine	166-177	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
10563385-1	1999	Earlier we showed that 4-hours treatment of cells K562 with the GTP-binding protein activator AlF4- (10 mM NaF + 20 microM AlCl3) increased the DNA fragmentation on an average to 5% of the total 3H-thymidine-labeled DNA.	tetrafluoroaluminate	94-98	C-X-C motif chemokine ligand 8	Homo sapiens	107-110
10348705-3	1999	Epinephrine increased LPS induced IL-8 production in a dose-dependent manner in the whole concentration range (0.001-100 microM) and 1 microM epinephrine increased IL-8 levels with 125%.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
10563385-1	1999	Earlier we showed that 4-hours treatment of cells K562 with the GTP-binding protein activator AlF4- (10 mM NaF + 20 microM AlCl3) increased the DNA fragmentation on an average to 5% of the total 3H-thymidine-labeled DNA.	Tritium	195-197	C-X-C motif chemokine ligand 8	Homo sapiens	107-110
10563385-1	1999	Earlier we showed that 4-hours treatment of cells K562 with the GTP-binding protein activator AlF4- (10 mM NaF + 20 microM AlCl3) increased the DNA fragmentation on an average to 5% of the total 3H-thymidine-labeled DNA.	Thymidine	198-207	C-X-C motif chemokine ligand 8	Homo sapiens	107-110
10348705-3	1999	Epinephrine increased LPS induced IL-8 production in a dose-dependent manner in the whole concentration range (0.001-100 microM) and 1 microM epinephrine increased IL-8 levels with 125%.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
10348705-3	1999	Epinephrine increased LPS induced IL-8 production in a dose-dependent manner in the whole concentration range (0.001-100 microM) and 1 microM epinephrine increased IL-8 levels with 125%.	Epinephrine	142-153	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
10348705-3	1999	Epinephrine increased LPS induced IL-8 production in a dose-dependent manner in the whole concentration range (0.001-100 microM) and 1 microM epinephrine increased IL-8 levels with 125%.	Epinephrine	142-153	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
10348705-5	1999	The potentiating effect of epinephrine was mediated by blood platelets, since IL-8 levels in samples containing platelets and stimulated with LPS and epinephrine (1-100 microM) were significantly higher (p&lt;0.05) than in control samples containing no platelets.	Epinephrine	27-38	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
10348705-8	1999	We demonstrate for the first time that epinephrine promotes LPS induced production of IL-8 in whole blood via an effect on blood platelets.	Epinephrine	39-50	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
9788508-4	1998	NiCl2 and CoCl2 upregulate, especially in concentrations of 1 mM, the expression of adhesion molecules (e.g., E-selectin and intercellular adhesion molecule-1), as well as the cytokines IL-6 and IL-8, as shown by enzyme immunoassay and Northern blot analysis.	nickel chloride	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
9934491-2	1998	Truncated analogs of tripterine as cytokine (IL-1 alpha, IL-1 beta, TNF-alpha, IL-6, and IL-8) release inhibitors are discussed.	celastrol	21-31	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
11498839-6	1999	In ALL, CR rate in patients with IL-8 &gt; 100 ng/L was lower than in those with IL-8 &lt; or = 100 ng/L (P &lt; 0.05).	Chromium	8-10	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
11498839-6	1999	In ALL, CR rate in patients with IL-8 &gt; 100 ng/L was lower than in those with IL-8 &lt; or = 100 ng/L (P &lt; 0.05).	Chromium	8-10	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
9788508-4	1998	NiCl2 and CoCl2 upregulate, especially in concentrations of 1 mM, the expression of adhesion molecules (e.g., E-selectin and intercellular adhesion molecule-1), as well as the cytokines IL-6 and IL-8, as shown by enzyme immunoassay and Northern blot analysis.	cobaltous chloride	10-15	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
9843840-8	1998	Dexamethasone prevented IL-8 and tumor necrosis factor-alpha secretion in ventilated macrophages.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	24-60
9830008-1	1998	We previously demonstrated that tumor necrosis factor-alpha (TNFalpha) and H2O2 differentially regulate interleukin-8 (IL-8) and intercellular adhesion molecule (ICAM-1) gene expression in endothelial and epithelial cells.	Hydrogen Peroxide	75-79	C-X-C motif chemokine ligand 8	Homo sapiens	104-117
9830008-1	1998	We previously demonstrated that tumor necrosis factor-alpha (TNFalpha) and H2O2 differentially regulate interleukin-8 (IL-8) and intercellular adhesion molecule (ICAM-1) gene expression in endothelial and epithelial cells.	Hydrogen Peroxide	75-79	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
9830008-2	1998	H2O2 induced IL-8 expression in the A549 and BEAS-2B epithelial cell lines, but not in the human microvessel endothelial cell line, HMEC-1 or human umbilical vein endothelial cells.	Hydrogen Peroxide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
9830008-10	1998	Moreover, the H2O2 concentration dependent increase in epithelial IL-8 mRNA expression directly corresponded to the H2O2 concentration dependent binding of AP-1 to the IL-8 promoter.	Hydrogen Peroxide	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
9830008-10	1998	Moreover, the H2O2 concentration dependent increase in epithelial IL-8 mRNA expression directly corresponded to the H2O2 concentration dependent binding of AP-1 to the IL-8 promoter.	Hydrogen Peroxide	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
9830008-10	1998	Moreover, the H2O2 concentration dependent increase in epithelial IL-8 mRNA expression directly corresponded to the H2O2 concentration dependent binding of AP-1 to the IL-8 promoter.	Hydrogen Peroxide	116-120	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
9830008-10	1998	Moreover, the H2O2 concentration dependent increase in epithelial IL-8 mRNA expression directly corresponded to the H2O2 concentration dependent binding of AP-1 to the IL-8 promoter.	Hydrogen Peroxide	116-120	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
9830008-14	1998	These data indicate that the cell type-specific induction of IL-8 gene expression by H2O2 and TNFalpha in HMEC-1 and A549 cells can be explained by the differential binding of AP-1 and NF-kappaB to the IL-8 promoter.	Hydrogen Peroxide	85-89	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
9830008-14	1998	These data indicate that the cell type-specific induction of IL-8 gene expression by H2O2 and TNFalpha in HMEC-1 and A549 cells can be explained by the differential binding of AP-1 and NF-kappaB to the IL-8 promoter.	Hydrogen Peroxide	85-89	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
9949625-11	1998	In our study, increased levels of TNF-alpha, IL-6 and especially IL-8 correlated with hepatic or renal dysfunction as evaluated by increased bilirubin and creatinine in plasma, while pulmonary complications correlated only with increased IL-6 levels.	Bilirubin	141-150	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
9988429-4	1998	Histamine has been shown to increase the adhesion of leucocytes to the endothelium and to stimulate production of IL-6 and IL-8 by endothelial cells.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
9877502-10	1998	Talc-induced inflammation in patients with idiopathic spontaneous pneumothorax and malignant pleural effusion is characterized by an influx of polymorphonuclear neutrophils related to interleukin-8, followed by an accumulation of monocytes.	Talc	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	184-197
9820828-4	1998	The lipid-induced stimulation of the phospholipase C/Ca2+ system was also attenuated in the dibutyryl cAMP-induced differentiated (neutrophil-like) cells, in which phospholipase C activation induced by NaF or formyl-Met-Leu-Phe was enhanced.	Cyclic AMP	102-106	C-X-C motif chemokine ligand 8	Homo sapiens	202-205
9879930-3	1998	Exposure of cells to NaF for 2 h also inhibited protein synthesis, cellular ATP level and functional mitochondrial activities in a dose-dependent manner.	Adenosine Triphosphate	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
9879930-4	1998	However, incubation of cells with NaF up to 12 mmol/L for 2 h depleted only 13% of cellular glutathione level.	Glutathione	92-103	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
9879930-5	1998	The IC50 of NaF on cellular ATP level was about 5.75 mmol/L.	Adenosine Triphosphate	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
9879930-9	1998	These results indicate that NaF can be toxic to oral mucosal fibroblasts in vitro by its inhibition of protein synthesis, mitochondrial function and depletion of cellular ATP.	Adenosine Triphosphate	171-174	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
9834272-5	1998	RESULTS: Administration of the antisense oligonucleotide blocked the production of human interleukin 1beta and interleukin 8 by intestinal epithelial cells and inhibited neutrophil influx into the E. histolytica-infected intestinal xenografts.	Oligonucleotides	41-56	C-X-C motif chemokine ligand 8	Homo sapiens	111-124
9949625-11	1998	In our study, increased levels of TNF-alpha, IL-6 and especially IL-8 correlated with hepatic or renal dysfunction as evaluated by increased bilirubin and creatinine in plasma, while pulmonary complications correlated only with increased IL-6 levels.	Creatinine	155-165	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
9826354-0	1998	Pseudomonas pyocyanin increases interleukin-8 expression by human airway epithelial cells.	Pyocyanine	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	32-45
9886550-9	1998	PGE2 stimulated release of MCP-1, IL-8 and IL-10 into the maternal and of MCP-1 and IL-8 into the fetal circulation of the placenta but had no effect on RANTES release.	Dinoprostone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
9886550-9	1998	PGE2 stimulated release of MCP-1, IL-8 and IL-10 into the maternal and of MCP-1 and IL-8 into the fetal circulation of the placenta but had no effect on RANTES release.	Dinoprostone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
9826354-4	1998	We find that pyocyanin increases release of interleukin-8 (IL-8) by both normal and CF airway epithelial cell lines and by primary airway epithelial cells.	Pyocyanine	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	44-57
9918428-0	1998	Bile acids inhibit tumour necrosis factor alpha-induced interleukin-8 production in human colon epithelial cells.	Bile Acids and Salts	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
9893037-3	1998	Live purified RSV (pRSV) induced a significant increase in IL-8 after 8 hr of exposure, while conditioned supernatants from pRSV-infected A549 cells (cRSV) induced IL-8 production in fresh A549 cultures within 4 hr of infection.	prsv	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
9893037-4	1998	Furthermore, cRSV that had been rendered non-infectious by ultraviolet-irradiation (UV-cRSV) or ribavirin treatment also induced an increased production of IL-8 in fresh A549 cells, suggesting that RSV induced the synthesis of a soluble mediator(s) which in turn enhanced the synthesis of IL-8.	crsv	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
9893037-4	1998	Furthermore, cRSV that had been rendered non-infectious by ultraviolet-irradiation (UV-cRSV) or ribavirin treatment also induced an increased production of IL-8 in fresh A549 cells, suggesting that RSV induced the synthesis of a soluble mediator(s) which in turn enhanced the synthesis of IL-8.	crsv	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	289-293
9893037-4	1998	Furthermore, cRSV that had been rendered non-infectious by ultraviolet-irradiation (UV-cRSV) or ribavirin treatment also induced an increased production of IL-8 in fresh A549 cells, suggesting that RSV induced the synthesis of a soluble mediator(s) which in turn enhanced the synthesis of IL-8.	crsv	87-91	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
9893037-4	1998	Furthermore, cRSV that had been rendered non-infectious by ultraviolet-irradiation (UV-cRSV) or ribavirin treatment also induced an increased production of IL-8 in fresh A549 cells, suggesting that RSV induced the synthesis of a soluble mediator(s) which in turn enhanced the synthesis of IL-8.	Ribavirin	96-105	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
9893038-7	1998	Phorbol 12-myristate 13-acetate pretreatment diminished the ability of BK to stimulate IL-8 production.	Tetradecanoylphorbol Acetate	0-31	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
9893038-8	1998	In addition, GF109203X, a selective protein kinase C inhibitor, blocked BK-induced IL-8 production.	bisindolylmaleimide I	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
9885886-9	1998	The cAMP production elicited by NaF or forskolin was lower in septic patients than in the controls (p &lt; 0.01).	Cyclic AMP	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
9918428-8	1998	These findings suggest that bile acids inhibit TNF alpha-induced IL-8 production by the colonic cells.	Bile Acids and Salts	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
9867034-1	1998	Bacteriochlorin a photodynamic therapy (BCA-PDT) caused inhibition of interleukin (IL)-8-activated neutrophil migration, at concentrations that did not induce membrane damage.	bacteriochlorin a	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	70-88
9916887-1	1998	We give here evidence that Purkinje neurons (PNs) of mouse cerebellar slices studied with patch clamp technique combined with laser confocal microscopy, respond to human IL-8 and GROalpha by (i) a cytosolic Ca2+ transient compatible with inositol (1,4,5) trisphosphate (InsP3) formation; (ii) an enhancement of the neurotransmitter release; and (iii) an impairment of the long-term depression of synaptic strength (LTD).	Inositol 1,4,5-Trisphosphate	238-268	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
9853284-6	1998	RESULTS: Apical stimulation of HPMC with IL-1 beta or TNF alpha resulted in a time and dose dependent up-regulation of IL-8, MCP-1 and RANTES mRNA expression and synthesis.	hydroxypropylmethylcellulose-lactose matrix	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
9853284-11	1998	CONCLUSIONS: These data demonstrate that HPMC synthesize IL-8, MCP-1 and RANTES in response to inflammatory cytokines.	hydroxypropylmethylcellulose-lactose matrix	41-45	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
10065903-6	1998	Cocaine also augmented apoptosis of brain endothelial cells and monocytes, increased secretion of four chemokines (interleukin-8, interferon-inducible protein-10, macrophage inflammatory protein-1alpha, and monocyte chemoattractant protein-1) and the cytokine, TNF-alpha, by human monocytes.	Cocaine	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	115-128
9820546-0	1998	Peroxynitrite mediates IL-8 gene expression and production in lipopolysaccharide-stimulated human whole blood.	Peroxynitrous Acid	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
10022774-10	1998	Prestimulation of the G-protein activity by sodium fluoride (NaF) or cholera toxin (CT), followed by rhFSH challenge, accounted for a decrease in the cAMP-mediated responsiveness, down to 69.4 +/- 2.8 or 74.2 +/- 1.9%, of control (P &lt; 0.001), respectively, indicating that the post-receptor events are critical for desensitization.	Sodium Fluoride	44-59	C-X-C motif chemokine ligand 8	Homo sapiens	61-64
10022774-10	1998	Prestimulation of the G-protein activity by sodium fluoride (NaF) or cholera toxin (CT), followed by rhFSH challenge, accounted for a decrease in the cAMP-mediated responsiveness, down to 69.4 +/- 2.8 or 74.2 +/- 1.9%, of control (P &lt; 0.001), respectively, indicating that the post-receptor events are critical for desensitization.	Cyclic AMP	150-154	C-X-C motif chemokine ligand 8	Homo sapiens	61-64
10022774-15	1998	The effects of the post-receptor stimulations (NaF or CT) on [125I]iodo-rhFSH binding were minor (8-12% reduction).	iodo-rhfsh	67-77	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
9820546-3	1998	The NO synthase inhibitors aminoguanidine and NG-nitro-L-arginine methyl ester (L-NAME) blocked IL-8 release by approximately 90% in response to LPS (1 microg/ml), but did not affect the production of IL-1beta or TNF-alpha.	NG-Nitroarginine Methyl Ester	46-78	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
9820546-3	1998	The NO synthase inhibitors aminoguanidine and NG-nitro-L-arginine methyl ester (L-NAME) blocked IL-8 release by approximately 90% in response to LPS (1 microg/ml), but did not affect the production of IL-1beta or TNF-alpha.	NG-Nitroarginine Methyl Ester	80-86	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
9820546-1	1998	Recent evidence indicates that free oxygen radicals, in particular hydroxyl radicals, may act as intracellular second messengers for the induction of IL-8, a potent chemoattractant and activator of neutrophil granulocytes.	free oxygen radicals	31-51	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
9820546-4	1998	Both aminoguanidine and L-NAME blocked the induction of IL-8 mRNA by LPS.	pimagedine	5-19	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
9820546-4	1998	Both aminoguanidine and L-NAME blocked the induction of IL-8 mRNA by LPS.	NG-Nitroarginine Methyl Ester	24-30	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
9820546-1	1998	Recent evidence indicates that free oxygen radicals, in particular hydroxyl radicals, may act as intracellular second messengers for the induction of IL-8, a potent chemoattractant and activator of neutrophil granulocytes.	Hydroxyl Radical	67-84	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
9820546-5	1998	Authentic ONOO- (2.5-80 microM) augmented IL-8 mRNA expression and stimulated IL-8 release in a concentration-dependent manner, whereas the NO-releasing compounds, S-nitroso-N-acetyl-DL-penicillamine and sodium nitroprusside failed to induce cytokine production.	onoo	10-14	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
9820546-2	1998	Here we report that peroxynitrite (ONOO-), formed by a reaction of nitric oxide (NO) with superoxide, mediates IL-8 gene expression and IL-8 production in LPS-stimulated human whole blood.	Peroxynitrous Acid	20-33	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
9820546-5	1998	Authentic ONOO- (2.5-80 microM) augmented IL-8 mRNA expression and stimulated IL-8 release in a concentration-dependent manner, whereas the NO-releasing compounds, S-nitroso-N-acetyl-DL-penicillamine and sodium nitroprusside failed to induce cytokine production.	onoo	10-14	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
9820546-6	1998	Combination of the NO-generating chemicals with a superoxide-generating system (xanthine/xanthine oxidase) markedly increased IL-8 release.	Superoxides	50-60	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
9820546-2	1998	Here we report that peroxynitrite (ONOO-), formed by a reaction of nitric oxide (NO) with superoxide, mediates IL-8 gene expression and IL-8 production in LPS-stimulated human whole blood.	Peroxynitrous Acid	20-33	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
9820546-8	1998	Furthermore, pyrrolidine dithiocarbamate, an inhibitor of activation of nuclear factor-gammaB, markedly attenuated the induction of IL-8 mRNA expression and IL-8 release by either LPS or ONOO-.	pyrrolidine dithiocarbamic acid	13-40	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
9820546-2	1998	Here we report that peroxynitrite (ONOO-), formed by a reaction of nitric oxide (NO) with superoxide, mediates IL-8 gene expression and IL-8 production in LPS-stimulated human whole blood.	oxido nitrite	35-40	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
9820546-8	1998	Furthermore, pyrrolidine dithiocarbamate, an inhibitor of activation of nuclear factor-gammaB, markedly attenuated the induction of IL-8 mRNA expression and IL-8 release by either LPS or ONOO-.	pyrrolidine dithiocarbamic acid	13-40	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
9820546-8	1998	Furthermore, pyrrolidine dithiocarbamate, an inhibitor of activation of nuclear factor-gammaB, markedly attenuated the induction of IL-8 mRNA expression and IL-8 release by either LPS or ONOO-.	oxido nitrite	187-192	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
9820546-2	1998	Here we report that peroxynitrite (ONOO-), formed by a reaction of nitric oxide (NO) with superoxide, mediates IL-8 gene expression and IL-8 production in LPS-stimulated human whole blood.	oxido nitrite	35-40	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
9820546-8	1998	Furthermore, pyrrolidine dithiocarbamate, an inhibitor of activation of nuclear factor-gammaB, markedly attenuated the induction of IL-8 mRNA expression and IL-8 release by either LPS or ONOO-.	oxido nitrite	187-192	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
9820546-9	1998	Our study identifies ONOO- as a novel signaling mechanism for IL-8 gene expression and suggests that inhibition of ONOO- formation or scavenging ONOO- may represent a novel therapeutic approach to inhibit IL-8 production that could lead to reduction of neutrophil accumulation and activation.	onoo	21-25	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
9820546-2	1998	Here we report that peroxynitrite (ONOO-), formed by a reaction of nitric oxide (NO) with superoxide, mediates IL-8 gene expression and IL-8 production in LPS-stimulated human whole blood.	Nitric Oxide	67-79	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
9820546-9	1998	Our study identifies ONOO- as a novel signaling mechanism for IL-8 gene expression and suggests that inhibition of ONOO- formation or scavenging ONOO- may represent a novel therapeutic approach to inhibit IL-8 production that could lead to reduction of neutrophil accumulation and activation.	onoo	21-25	C-X-C motif chemokine ligand 8	Homo sapiens	205-209
9820546-9	1998	Our study identifies ONOO- as a novel signaling mechanism for IL-8 gene expression and suggests that inhibition of ONOO- formation or scavenging ONOO- may represent a novel therapeutic approach to inhibit IL-8 production that could lead to reduction of neutrophil accumulation and activation.	onoo	115-119	C-X-C motif chemokine ligand 8	Homo sapiens	205-209
9820546-2	1998	Here we report that peroxynitrite (ONOO-), formed by a reaction of nitric oxide (NO) with superoxide, mediates IL-8 gene expression and IL-8 production in LPS-stimulated human whole blood.	Nitric Oxide	67-79	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
9820546-9	1998	Our study identifies ONOO- as a novel signaling mechanism for IL-8 gene expression and suggests that inhibition of ONOO- formation or scavenging ONOO- may represent a novel therapeutic approach to inhibit IL-8 production that could lead to reduction of neutrophil accumulation and activation.	onoo	115-119	C-X-C motif chemokine ligand 8	Homo sapiens	205-209
9813140-4	1998	Pretreatment with nicotine caused a significant inhibition of LPS-induced IL-1, IL-8, and PGE2 expression at the transcriptional level in U937 cells.	Nicotine	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
9820546-2	1998	Here we report that peroxynitrite (ONOO-), formed by a reaction of nitric oxide (NO) with superoxide, mediates IL-8 gene expression and IL-8 production in LPS-stimulated human whole blood.	Superoxides	90-100	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
9820546-2	1998	Here we report that peroxynitrite (ONOO-), formed by a reaction of nitric oxide (NO) with superoxide, mediates IL-8 gene expression and IL-8 production in LPS-stimulated human whole blood.	Superoxides	90-100	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
9820546-3	1998	The NO synthase inhibitors aminoguanidine and NG-nitro-L-arginine methyl ester (L-NAME) blocked IL-8 release by approximately 90% in response to LPS (1 microg/ml), but did not affect the production of IL-1beta or TNF-alpha.	pimagedine	27-41	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
9784544-9	1998	RSLA blocked H. pylori LPS-induced monocyte IL-8 release in a dose-dependent fashion (maximal inhibition 82%, P &lt; 0.001).	RSLA	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
9802986-5	1998	After treatment of HIMEC or PMEC with histamine or thrombin, a dramatic increase in supernatant IL-8 concentration was observed within 3 min, whereas no increase in IL-8 was detected in supernatants of identically treated HUVEC cultures.	himec	19-24	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
9802986-5	1998	After treatment of HIMEC or PMEC with histamine or thrombin, a dramatic increase in supernatant IL-8 concentration was observed within 3 min, whereas no increase in IL-8 was detected in supernatants of identically treated HUVEC cultures.	PMEC	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
9802986-5	1998	After treatment of HIMEC or PMEC with histamine or thrombin, a dramatic increase in supernatant IL-8 concentration was observed within 3 min, whereas no increase in IL-8 was detected in supernatants of identically treated HUVEC cultures.	Histamine	38-47	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
9802986-6	1998	Histamine or thrombin treatment also caused IL-8-containing granules to rapidly disappear from HIMEC.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
9802986-7	1998	In HUVEC, IL-8-containing granules were inducible by treatment with recombinant human IL-1beta for 24 h; additional histamine treatment doubled IL-8 secretion from HUVEC in the same rapid manner observed for mucosal EC.	Histamine	116-125	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
9802987-5	1998	IL-8 was retained in these storage organelles for several days after the removal of the stimulus and could be released by EC secretagogues such as phorbol myristate acetate, the calcium ionophore A23187, and histamine.	Tetradecanoylphorbol Acetate	147-172	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9802987-5	1998	IL-8 was retained in these storage organelles for several days after the removal of the stimulus and could be released by EC secretagogues such as phorbol myristate acetate, the calcium ionophore A23187, and histamine.	Calcium	178-185	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9802987-5	1998	IL-8 was retained in these storage organelles for several days after the removal of the stimulus and could be released by EC secretagogues such as phorbol myristate acetate, the calcium ionophore A23187, and histamine.	Calcimycin	196-202	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9802987-5	1998	IL-8 was retained in these storage organelles for several days after the removal of the stimulus and could be released by EC secretagogues such as phorbol myristate acetate, the calcium ionophore A23187, and histamine.	Histamine	208-217	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9831837-0	1998	Technetium Tc 99m hexamethyl propylene amine oxine leukocyte scintigraphy in patients with ulcerative colitis: correlation with clinical, biologic, endoscopic, and pathologic intensity, and local release of interleukin 8.	technetium tc 99	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	207-220
9842932-4	1998	Despite a moderate increase of DC apoptosis in the presence of H2O2, we observed that H2O2 stimulated the production of IL-8 and TFN-alpha by DC in a dose-dependent manner.	Hydrogen Peroxide	86-90	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
9858061-4	1998	THC decreased constitutive production of IL-8, MIP-1alpha, MIP-1beta, and RANTES and phorbol ester stimulated production of TNF-alpha, GM-CSF and IFN-gamma by NK cells.	Dronabinol	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
9784544-10	1998	RSLA also inhibited HPE-induced IL-8 release (by 93%, P &lt; 0.001).	RSLA	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
9784544-11	1998	The anti-CD14 monoclonal antibody 60bca substantially inhibited IL-8 release from HPE-stimulated monocytes (by 88%, P &lt; 0.01), whereas the nonblocking anti-CD14 monoclonal antibody did not.	60bca	34-39	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
9732469-5	1998	The photolysis t(1/2) of phloxine B at 29 +/- 1 degreesC was 25, 32, 128, and 755 min in the buffered NaF, NaCl, NaBr, and NaI solutions, respectively.	Eosine I Bluish	26-36	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
9848541-2	1998	Approximately 70% to 75% of LJP patients have impaired neutrophil chemotaxis towards a number of chemoattractants including N-formyl-methionyl-leucyl-phenyl-alanine, complement fragment C5a, leukotriene B4, and interleukin 8 (IL-8).	CB 1837	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	211-224
9848541-2	1998	Approximately 70% to 75% of LJP patients have impaired neutrophil chemotaxis towards a number of chemoattractants including N-formyl-methionyl-leucyl-phenyl-alanine, complement fragment C5a, leukotriene B4, and interleukin 8 (IL-8).	CB 1837	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	226-230
9848541-3	1998	The aim of the present study was to observe the role of IL-8 in the pathogenesis of LJP.	CB 1837	84-87	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
9848541-9	1998	It was observed that the concentration of IL-8 demonstrated a negative correlation with gingival index in the LJP group.	CB 1837	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
9840646-11	1998	IL-8 generates high [Ca2+]i spikes using intracellular calcium stores only.	Calcium	55-62	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9774447-2	1998	We reported previously that paclitaxel can induce interleukin (IL)-8 promoter activation in subgroups of ovarian cancer through the activation of both AP-1 and nuclear factor kappaB.	Paclitaxel	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	50-68
9774447-3	1998	Further analysis of paclitaxel analogs indicates that the degree of IL-8 induction by analysis correlates with the extent of cell death; however, IL-8 itself is not the cause of cell death.	Paclitaxel	20-30	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
9774447-8	1998	Paclitaxel-induced IL-8 promoter activation was inhibited by dominant-inhibitory mutants of JNK, p38, and the super-repressor form of IkappaBalpha, but not by dominant-inhibitory forms of ERK1.	Paclitaxel	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
9780210-2	1998	Incubation of peripheral blood neutrophils with thapsigargin, an inhibitor of the endoplasmic reticulum Ca2+-sequestering-ATPase, causes a dose-dependent induction of IL-8 synthesis that continues for up to 8 h. Cycloheximide inhibits the thapsigargin-induced IL-8 production, suggesting the induction of protein synthesis de novo.	Thapsigargin	48-60	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
9780210-2	1998	Incubation of peripheral blood neutrophils with thapsigargin, an inhibitor of the endoplasmic reticulum Ca2+-sequestering-ATPase, causes a dose-dependent induction of IL-8 synthesis that continues for up to 8 h. Cycloheximide inhibits the thapsigargin-induced IL-8 production, suggesting the induction of protein synthesis de novo.	Thapsigargin	48-60	C-X-C motif chemokine ligand 8	Homo sapiens	260-264
9780210-2	1998	Incubation of peripheral blood neutrophils with thapsigargin, an inhibitor of the endoplasmic reticulum Ca2+-sequestering-ATPase, causes a dose-dependent induction of IL-8 synthesis that continues for up to 8 h. Cycloheximide inhibits the thapsigargin-induced IL-8 production, suggesting the induction of protein synthesis de novo.	Cycloheximide	212-225	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
9780210-2	1998	Incubation of peripheral blood neutrophils with thapsigargin, an inhibitor of the endoplasmic reticulum Ca2+-sequestering-ATPase, causes a dose-dependent induction of IL-8 synthesis that continues for up to 8 h. Cycloheximide inhibits the thapsigargin-induced IL-8 production, suggesting the induction of protein synthesis de novo.	Thapsigargin	239-251	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
9780210-3	1998	In addition, Northern blot analysis of mRNA isolated from neutrophils indicates that thapsigargin treatment increases IL-8 mRNA in a time- and dose-dependent manner.	Thapsigargin	85-97	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
9780210-5	1998	Addition of EGTA before thapsigargin inhibited the induction of IL-8 production.	Egtazic Acid	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
9780210-5	1998	Addition of EGTA before thapsigargin inhibited the induction of IL-8 production.	Thapsigargin	24-36	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
9780210-6	1998	Experiments in which EGTA was added at various times after thapsigargin treatment indicated that a sustained Ca2+ influx was required for maximum IL-8 production.	Egtazic Acid	21-25	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
9780210-6	1998	Experiments in which EGTA was added at various times after thapsigargin treatment indicated that a sustained Ca2+ influx was required for maximum IL-8 production.	Thapsigargin	59-71	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
9780210-7	1998	Ascomycin and cyclosporin A, inhibitors of the Ca2+-dependent phosphatase, calcineurin, also inhibited thapsigargin-induced IL-8 production.	immunomycin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
9780210-7	1998	Ascomycin and cyclosporin A, inhibitors of the Ca2+-dependent phosphatase, calcineurin, also inhibited thapsigargin-induced IL-8 production.	Cyclosporine	14-27	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
9780210-7	1998	Ascomycin and cyclosporin A, inhibitors of the Ca2+-dependent phosphatase, calcineurin, also inhibited thapsigargin-induced IL-8 production.	Thapsigargin	103-115	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
9761763-5	1998	Using cultures of primary human pulmonary fibroblasts and pulmonary vascular smooth muscle cells (VSMC) we show that hypoxia (3% O2) induced transcription and translation of IL-6 (4- to 5-fold) and IL-8 (5- to 6-fold) in both cell types.	Oxygen	129-131	C-X-C motif chemokine ligand 8	Homo sapiens	198-202
9809497-1	1998	BACKGROUND: Leukotriene B4 (LTB4), a potent chemokinetic mediator for neutrophils, is enhanced by interleukin-8 (IL-8) and may play a key role in the inflammatory response of asthma.	Leukotriene B4	12-26	C-X-C motif chemokine ligand 8	Homo sapiens	98-111
9809497-1	1998	BACKGROUND: Leukotriene B4 (LTB4), a potent chemokinetic mediator for neutrophils, is enhanced by interleukin-8 (IL-8) and may play a key role in the inflammatory response of asthma.	Leukotriene B4	12-26	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
9809497-2	1998	OBJECTIVE: The aim of the present study was to investigate whether zileuton, a 5-lipoxygenase antagonist known to inhibit LTB4 production and recruitment of eosinophils/neutrophils in bronchoalveolar fluid, could affect the production of LTB4 and IL-8 by allergen-stimulated peripheral blood mononuclear cells in vitro from patients with asthma and/or allergic rhinitis.	zileuton	67-75	C-X-C motif chemokine ligand 8	Homo sapiens	247-251
9809497-9	1998	CONCLUSIONS: The zileuton-induced attenuation of LTB4 production by allergen-stimulated peripheral blood mononuclear cells from patients with asthma and/or allergic rhinitis occurs independently from the allergen-stimulated IL-8 production.	zileuton	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	224-228
9751519-5	1998	Basal IL-8 release by cultured hOC or hOCL was orders of magnitude greater than the release of the proinflammatory cytokines IL-1beta, IL-6, and tumor necrosis factor-alpha.	(2S)-2-HYDROXYOCTANOIC ACID	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
9751519-5	1998	Basal IL-8 release by cultured hOC or hOCL was orders of magnitude greater than the release of the proinflammatory cytokines IL-1beta, IL-6, and tumor necrosis factor-alpha.	Hypochlorous Acid	38-42	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
9751519-7	1998	Therefore, the potential inflammation-mediated induction of IL-8 was directly assessed using cultured hOCL.	Hypochlorous Acid	102-106	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
9751519-10	1998	We conclude that hOC and hOCL synthesize and secrete high constitutive and inflammation-stimulated levels of the chemokine IL-8.	(2S)-2-HYDROXYOCTANOIC ACID	17-20	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
9751519-10	1998	We conclude that hOC and hOCL synthesize and secrete high constitutive and inflammation-stimulated levels of the chemokine IL-8.	Hypochlorous Acid	25-29	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
9792213-7	1998	In fact, treatments of animals with (1) histamine H1 or serotonin antagonists or with (2) the mast cell stabilizer cromolyn or with (3) prior depletion of intact mast cells are maneuvers that successfully reduce eosinophil, neutrophil and monocyte extravasation in response to eotaxin, interleukin-8 or monocyte chemoattractant protein-1, respectively.	histamine h1	40-52	C-X-C motif chemokine ligand 8	Homo sapiens	286-299
9820635-3	1998	Serum levels of IL-8 were also markedly increased in the patients compared to controls, and they were correlated positively with the levels of serum sE-selectin, sICAM, sVCAM, IL-1beta and TNF-alpha, and inversely with the number of circulating neutrophils.	se-selectin	149-160	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
9761780-7	1998	Induction of the stress response with PGA1 and concomitant induction of I-kappaBalpha were associated with inhibition of TNF-alpha-mediated secretion of interleukin 8 and with inhibition of TNF-alpha-mediated nuclear translocation and activation of NF-kappaB.	prostaglandin A1	38-42	C-X-C motif chemokine ligand 8	Homo sapiens	153-166
9792213-7	1998	In fact, treatments of animals with (1) histamine H1 or serotonin antagonists or with (2) the mast cell stabilizer cromolyn or with (3) prior depletion of intact mast cells are maneuvers that successfully reduce eosinophil, neutrophil and monocyte extravasation in response to eotaxin, interleukin-8 or monocyte chemoattractant protein-1, respectively.	Cromolyn Sodium	115-123	C-X-C motif chemokine ligand 8	Homo sapiens	286-299
9831326-8	1998	Eosinophil O2- production, LTC4 release, and IL-8 production were also inhibited by sulochrin.	sulochrin	84-93	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
9768679-6	1998	A 48-h treatment of cytotrophoblasts with 100 nmol/L DEX significantly reduced the production of IL-8 to 24+/-1% of control levels (P &lt; 0.01).	Dexamethasone	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
9768679-7	1998	DEX and cortisol mediated a dose-dependent inhibition of IL-8 expression, with ED50 values of 5 and 50 nmol/L, respectively.	Dexamethasone	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
9768679-7	1998	DEX and cortisol mediated a dose-dependent inhibition of IL-8 expression, with ED50 values of 5 and 50 nmol/L, respectively.	Hydrocortisone	8-16	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
9759900-0	1998	Prostaglandin E2 stimulates IL-8 gene expression in human colonic epithelial cells by a posttranscriptional mechanism.	Dinoprostone	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
9759900-3	1998	As PGE2 is central in gut inflammation and modulates a variety of mucosal epithelial cell functions, we determined whether PGE2 can affect the expression of IL-8.	Dinoprostone	123-127	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
9809627-0	1998	Nitric oxide-mediated modulation of interleukin-8 production by a human glioblastoma cell line, T98G, cocultured with myeloid and monocytic cell lines.	Nitric Oxide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	36-49
9759900-4	1998	Exogenous PGE2 induced the accumulation of IL-8 mRNA and protein production in a dose- and time-dependent manner in T84 human colonic epithelial cells.	Dinoprostone	10-14	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
9809627-2	1998	Pretreatment of HL-60 or THP-1 cells with phorbol myristate acetate (PMA) enhanced their capacity to induce IL-8 production by T98G cells.	Tetradecanoylphorbol Acetate	42-67	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
9809627-2	1998	Pretreatment of HL-60 or THP-1 cells with phorbol myristate acetate (PMA) enhanced their capacity to induce IL-8 production by T98G cells.	Tetradecanoylphorbol Acetate	69-72	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
9809627-6	1998	Because RAW cells produce large amounts of nitric oxide (NO), we assumed that the suppression of IL-8 production was ascribable to the NO produced by the RAW cells.	Nitric Oxide	43-55	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
9809627-8	1998	The involvement of NO in the suppression of IL-8 production was confirmed by the finding that N-monomethyl-L-arginine (NMMA), which inhibits NO production, reversed this suppression, whereas S-nitroso-N-acetyl-D,L-penicillamine (SNAP), a strong NO generator, suppressed IL-8 production.	omega-N-Methylarginine	94-117	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
9809627-8	1998	The involvement of NO in the suppression of IL-8 production was confirmed by the finding that N-monomethyl-L-arginine (NMMA), which inhibits NO production, reversed this suppression, whereas S-nitroso-N-acetyl-D,L-penicillamine (SNAP), a strong NO generator, suppressed IL-8 production.	omega-N-Methylarginine	94-117	C-X-C motif chemokine ligand 8	Homo sapiens	270-274
9792581-10	1998	Multiple regression analyses showed that arterial PCO2 was significantly correlated with SOT, LECT, and CI (r=0.51; r2=0.26; p&lt;0.000001); the correlation became stronger considering only CSR patients (r=0.64; r2=0.4; p&lt;0.001).	pco2	50-54	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
9809627-8	1998	The involvement of NO in the suppression of IL-8 production was confirmed by the finding that N-monomethyl-L-arginine (NMMA), which inhibits NO production, reversed this suppression, whereas S-nitroso-N-acetyl-D,L-penicillamine (SNAP), a strong NO generator, suppressed IL-8 production.	omega-N-Methylarginine	119-123	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
9759900-5	1998	Forskolin and dibutyryl cAMP, which increase intracellular cAMP, stimulated IL-8 in a fashion similar to that of PGE2.	Colforsin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
9809627-8	1998	The involvement of NO in the suppression of IL-8 production was confirmed by the finding that N-monomethyl-L-arginine (NMMA), which inhibits NO production, reversed this suppression, whereas S-nitroso-N-acetyl-D,L-penicillamine (SNAP), a strong NO generator, suppressed IL-8 production.	omega-N-Methylarginine	119-123	C-X-C motif chemokine ligand 8	Homo sapiens	270-274
9759900-5	1998	Forskolin and dibutyryl cAMP, which increase intracellular cAMP, stimulated IL-8 in a fashion similar to that of PGE2.	Cyclic AMP	24-28	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
9809627-8	1998	The involvement of NO in the suppression of IL-8 production was confirmed by the finding that N-monomethyl-L-arginine (NMMA), which inhibits NO production, reversed this suppression, whereas S-nitroso-N-acetyl-D,L-penicillamine (SNAP), a strong NO generator, suppressed IL-8 production.	snap	229-233	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
9759900-6	1998	PGE2 and PGE2 receptor agonists coupling through EP4 receptors elevated intracellular cAMP and up-regulated IL-8 mRNA expression by activating protein kinase A.	Dinoprostone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
9759900-8	1998	However, PGE2, forskolin, and PMA enhanced the stability of IL-8 mRNA transcripts, suggesting the involvement of posttranscriptional regulation.	Dinoprostone	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
9759900-8	1998	However, PGE2, forskolin, and PMA enhanced the stability of IL-8 mRNA transcripts, suggesting the involvement of posttranscriptional regulation.	Colforsin	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
9759900-8	1998	However, PGE2, forskolin, and PMA enhanced the stability of IL-8 mRNA transcripts, suggesting the involvement of posttranscriptional regulation.	Tetradecanoylphorbol Acetate	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
9759900-9	1998	Chloramphenicol acetyltransferase reporter gene transfection studies confirmed the presence of a PGE2 responsive cis-element(s) in the IL-8 3" untranslated region.	Dinoprostone	97-101	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
9759900-11	1998	These results highlight a novel role for PGE2 in up-regulating IL-8 gene expression by colonic epithelial cells, which may contribute to exacerbation of inflammation in the gastrointestinal tract.	Dinoprostone	41-45	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
9766632-1	1998	Interleukin-8 (IL-8) priming was studied in neutrophils to examine its dependency on altered calcium fluxes and for similarity to lipopolysaccharide (LPS).	Calcium	93-100	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
9766632-4	1998	In comparison to LPS and tumor necrosis factor (TNF), IL-8 was a much weaker priming agent as measured by either O2- or H2O2 production.	Oxygen	113-115	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
9740146-10	1998	TPA (10 nmol/L) also stimulated the production of IL-6 and IL-8 by these cells, but inhibited that of monocyte chemoattractant protein-1.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
9766632-4	1998	In comparison to LPS and tumor necrosis factor (TNF), IL-8 was a much weaker priming agent as measured by either O2- or H2O2 production.	Hydrogen Peroxide	120-124	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
9766632-5	1998	Despite their large disparity in potency, IL-8 and LPS printing were additive using fMLP, a receptor-dependent stimulator, and synergistic using the post-receptor, protein kinase C activator, phorbol 12-myristate 13-acetate (PMA) to trigger the respiratory burst.	Tetradecanoylphorbol Acetate	192-223	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
9766632-5	1998	Despite their large disparity in potency, IL-8 and LPS printing were additive using fMLP, a receptor-dependent stimulator, and synergistic using the post-receptor, protein kinase C activator, phorbol 12-myristate 13-acetate (PMA) to trigger the respiratory burst.	Tetradecanoylphorbol Acetate	225-228	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
9784408-4	1998	Finally, the specific MEK inhibitor PD98059 inhibited ICAM-1-induced IL-8 and RANTES production in endothelial cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	36-43	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
9728050-7	1998	The same acute exposure to As, V, or Zn that activated MAPK was sufficient to induce a subsequent increase in IL-8 protein expression in BEAS cells.	Arsenic	27-29	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
9728050-7	1998	The same acute exposure to As, V, or Zn that activated MAPK was sufficient to induce a subsequent increase in IL-8 protein expression in BEAS cells.	Vanadium	31-32	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
9728050-7	1998	The same acute exposure to As, V, or Zn that activated MAPK was sufficient to induce a subsequent increase in IL-8 protein expression in BEAS cells.	Zinc	37-39	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
9730996-5	1998	There was a significant (p &lt; 0.05) decrease in sputum leukocyte density and IL-1beta, IL-8, and LTB4 after fluticasone treatment.	Fluticasone	110-121	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
9829345-6	1998	Plasma glucose level was determined in NaF preserved plasma using the glucose oxidase method.	Glucose	7-14	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
10557188-7	1998	RESULTS: Part 1: IL-8 level in the PMSF samples was significantly greater than that in the control group (3.01 +/- 5.79 mg/L vs 0.05 +/- 0.15 mg/L, respectively P &lt; .001).	Phenylmethylsulfonyl Fluoride	35-39	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
9786474-6	1998	The production of both IL-8 (a potent neutrophil activator) and TNF-alpha in the human monocytic THP-1 cell line was reduced by fosfomycin-treated basolateral medium in this system.	Fosfomycin	128-138	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
9831176-9	1998	Dexamethasone partially inhibited the cytokine-induced release of MCP-1 and IL-8 and the expression of ICAM-1, CD40, and HLA class II molecules by human bronchial epithelial cells.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
9758900-0	1998	Suppressive effects of SP-A on ionomycin-induced IL-8 production and release by eosinophils.	Ionomycin	31-40	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
9725262-3	1998	Binding and competition studies with 125I-labeled IL-8 and its homologue melanoma growth stimulating activity (125I-labeled MGSA) revealed two specific binding sites for IL-8, K1 = 1.1 x 10(11) M(-1) and K2 = 5 x 10(7) M(-1); and for MGSA, K1 = 2.8 x 10(10) M(-1) and K2 = 5 x 10(7) M(-1).	Iodine-125	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
9725250-9	1998	The nonselective COX inhibitor indomethacin and the selective COX-2 inhibitor NS-398 strongly inhibited BK-stimulated PGE2 and IL-8 production.	Indomethacin	31-43	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
9725250-10	1998	The COX substrate arachidonic acid also caused PGE2 and IL-8 production, and its effect was inhibited by nonselective COX inhibitors but unaffected by NS-398.	Arachidonic Acid	18-34	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
9725250-11	1998	Both the BK- and arachidonic acid-induced IL-8 production was inhibited by the protein synthesis inhibitors cycloheximide and actinomycin D and by the steroid dexamethasone.	Arachidonic Acid	17-33	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
9725250-9	1998	The nonselective COX inhibitor indomethacin and the selective COX-2 inhibitor NS-398 strongly inhibited BK-stimulated PGE2 and IL-8 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	78-84	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
9725250-11	1998	Both the BK- and arachidonic acid-induced IL-8 production was inhibited by the protein synthesis inhibitors cycloheximide and actinomycin D and by the steroid dexamethasone.	Cycloheximide	108-121	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
9725262-3	1998	Binding and competition studies with 125I-labeled IL-8 and its homologue melanoma growth stimulating activity (125I-labeled MGSA) revealed two specific binding sites for IL-8, K1 = 1.1 x 10(11) M(-1) and K2 = 5 x 10(7) M(-1); and for MGSA, K1 = 2.8 x 10(10) M(-1) and K2 = 5 x 10(7) M(-1).	Iodine-125	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
9725250-11	1998	Both the BK- and arachidonic acid-induced IL-8 production was inhibited by the protein synthesis inhibitors cycloheximide and actinomycin D and by the steroid dexamethasone.	Dactinomycin	126-139	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
9725250-11	1998	Both the BK- and arachidonic acid-induced IL-8 production was inhibited by the protein synthesis inhibitors cycloheximide and actinomycin D and by the steroid dexamethasone.	Steroids	151-158	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
9725250-11	1998	Both the BK- and arachidonic acid-induced IL-8 production was inhibited by the protein synthesis inhibitors cycloheximide and actinomycin D and by the steroid dexamethasone.	Dexamethasone	159-172	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
9725262-3	1998	Binding and competition studies with 125I-labeled IL-8 and its homologue melanoma growth stimulating activity (125I-labeled MGSA) revealed two specific binding sites for IL-8, K1 = 1.1 x 10(11) M(-1) and K2 = 5 x 10(7) M(-1); and for MGSA, K1 = 2.8 x 10(10) M(-1) and K2 = 5 x 10(7) M(-1).	Iodine-125	111-115	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
9725250-12	1998	Furthermore, exogenous PGE2 and calcium ionophore A23187 also stimulated IL-8 release.	Dinoprostone	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
9725250-12	1998	Furthermore, exogenous PGE2 and calcium ionophore A23187 also stimulated IL-8 release.	Calcium	32-39	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
9725262-3	1998	Binding and competition studies with 125I-labeled IL-8 and its homologue melanoma growth stimulating activity (125I-labeled MGSA) revealed two specific binding sites for IL-8, K1 = 1.1 x 10(11) M(-1) and K2 = 5 x 10(7) M(-1); and for MGSA, K1 = 2.8 x 10(10) M(-1) and K2 = 5 x 10(7) M(-1).	Iodine-125	111-115	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
9725250-12	1998	Furthermore, exogenous PGE2 and calcium ionophore A23187 also stimulated IL-8 release.	Calcimycin	50-56	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
9759922-12	1998	Consistent with this observation is that treatments either with KA and NMDA induced an inhibition (about 30%) of NaF-stimulated PI hydrolysis which occurs through the direct activation of G proteins.	N-Methylaspartate	71-75	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
9725250-13	1998	BK-induced IL-8 release was mimicked by the BK B2 receptor agonist (Tyr(Me)8)-BK and was potently inhibited by the selective B2 receptor antagonist HOE-140.	tyr(me)8	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
9725250-13	1998	BK-induced IL-8 release was mimicked by the BK B2 receptor agonist (Tyr(Me)8)-BK and was potently inhibited by the selective B2 receptor antagonist HOE-140.	4-hydroxy-2-octenal	148-151	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
9725250-14	1998	These results suggest that human ASM can be a source of IL-8 and also that endogenous prostanoids, involving both COX-1 and COX-2, have a novel role in mediating BK-induced IL-8 production.	Prostaglandins	86-97	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
10921031-8	1998	CONCLUSION: Serum levels of IL-6, sgp130, IL-8 may reflect patient"s responsiveness to ATRA treatment, predict hyperleukocytosis and intercurrent infection.	Tretinoin	87-91	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
9745529-0	1998	Anti-rat IL-8 (CINC) monoclonal antibody administration reduces ischemia-reperfusion injury in small intestine.	Zinc	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
9744647-3	1998	After incubating 24 h, the combination of lipopolysaccharide and Fragmin induced significantly greater concentrations of interleukin 1 (IL)-1beta (25+/-10 ng/mL; x +/- standard error), IL-8 (21+/-6), and tumor necrosis factor (TNF)alpha (.48+/-.24) compared with heparinized blood (p &lt; .05).	Dalteparin	65-72	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
9744647-5	1998	Average levels of proinflammatory cytokines (IL-1beta, IL-6, IL-8, and TNFalpha) were greater with Fragmin anticoagulation for 36 of 40 comparisons, and patterns were similar for 6 h and 24 h incubations.	Dalteparin	99-106	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
9708989-2	1998	Using flow cytometric assays and pertussis toxin (PT) treatment of human neutrophils, we have shown that actin polymerization stimulated with the chemoattractants N-formyl-Met-Leu-Phe, leukotriene B4, and interleukin-8 exhibits threshold behavior in terms of G-protein number.	Leukotrienes	185-196	C-X-C motif chemokine ligand 8	Homo sapiens	205-218
9685620-0	1998	The effect of interleukin-8 and granulocyte macrophage colony stimulating factor on the response of neutrophils to formyl methionyl leucyl phenylalanine.	N-Formylmethionine Leucyl-Phenylalanine	115-152	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
9712064-4	1998	Expression of ICAM-1, VCAM-1, and E-selectin was not altered following incubation with tryptase, but the potent granulocyte chemoattractant IL-8 was released in a dose-dependent fashion in response to physiologically relevant concentrations, with maximal levels in supernatants after 24 h. The actions of tryptase on HUVEC were inhibited by heat inactivation of the enzyme, or by preincubating with the protease inhibitors leupeptin or benzamidine, suggesting a requirement for an intact catalytic site.	leupeptin	423-432	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
9712064-4	1998	Expression of ICAM-1, VCAM-1, and E-selectin was not altered following incubation with tryptase, but the potent granulocyte chemoattractant IL-8 was released in a dose-dependent fashion in response to physiologically relevant concentrations, with maximal levels in supernatants after 24 h. The actions of tryptase on HUVEC were inhibited by heat inactivation of the enzyme, or by preincubating with the protease inhibitors leupeptin or benzamidine, suggesting a requirement for an intact catalytic site.	benzamidine	436-447	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
9738952-6	1998	On the other hand, tetrodotoxin (TTX) and cyclosporin A inhibited only the NaF-induced 45Ca2+ influx (IC50 = 21 mol/l and 28 mol/l, respectively).	Tetrodotoxin	19-31	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
9698365-2	1998	The binding site on the chemokine interleukin-8 (IL-8) for the glycosaminoglycan heparin has been characterized using a systematic series of site-directed mutants of IL-8 in which the basic residues of the protein have been replaced by alanine.	Alanine	236-243	C-X-C motif chemokine ligand 8	Homo sapiens	34-47
9698365-2	1998	The binding site on the chemokine interleukin-8 (IL-8) for the glycosaminoglycan heparin has been characterized using a systematic series of site-directed mutants of IL-8 in which the basic residues of the protein have been replaced by alanine.	Alanine	236-243	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
9698365-4	1998	Heparin-derived disaccharides that could disrupt the IL-8-heparin Sepharose interaction were identified by a competitive binding assay.	heparin-derived disaccharides	0-29	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
9698365-4	1998	Heparin-derived disaccharides that could disrupt the IL-8-heparin Sepharose interaction were identified by a competitive binding assay.	Sepharose	66-75	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
9698365-5	1998	Heteronuclear NMR spectroscopic titration of 15N-labeled IL-8 with a trisulfated disaccharide revealed a cluster of residues on IL-8 which were perturbed by disaccharide binding.	15n	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
9698365-5	1998	Heteronuclear NMR spectroscopic titration of 15N-labeled IL-8 with a trisulfated disaccharide revealed a cluster of residues on IL-8 which were perturbed by disaccharide binding.	15n	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
9698365-5	1998	Heteronuclear NMR spectroscopic titration of 15N-labeled IL-8 with a trisulfated disaccharide revealed a cluster of residues on IL-8 which were perturbed by disaccharide binding.	trisulfated disaccharide	69-93	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
9698365-5	1998	Heteronuclear NMR spectroscopic titration of 15N-labeled IL-8 with a trisulfated disaccharide revealed a cluster of residues on IL-8 which were perturbed by disaccharide binding.	trisulfated disaccharide	69-93	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
9698365-5	1998	Heteronuclear NMR spectroscopic titration of 15N-labeled IL-8 with a trisulfated disaccharide revealed a cluster of residues on IL-8 which were perturbed by disaccharide binding.	Disaccharides	81-93	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
9738952-6	1998	On the other hand, tetrodotoxin (TTX) and cyclosporin A inhibited only the NaF-induced 45Ca2+ influx (IC50 = 21 mol/l and 28 mol/l, respectively).	Tetrodotoxin	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
9698365-5	1998	Heteronuclear NMR spectroscopic titration of 15N-labeled IL-8 with a trisulfated disaccharide revealed a cluster of residues on IL-8 which were perturbed by disaccharide binding.	Disaccharides	81-93	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
9698365-6	1998	These data identify a heparin-binding surface on IL-8 that includes the C-terminal alpha-helix and the proximal loop around residues 18-23.	Heparin	22-29	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
9738952-6	1998	On the other hand, tetrodotoxin (TTX) and cyclosporin A inhibited only the NaF-induced 45Ca2+ influx (IC50 = 21 mol/l and 28 mol/l, respectively).	Cyclosporine	42-55	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
9738952-9	1998	Thus, the Gardos effect induced by NaVO3 and NaF represents two phenomena activated by different mechanisms present in the cryptic state in the RBC membrane.	gardos	10-16	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
9700090-4	1998	ICI 200,355 (an inhibitor of neutrophil elastase and proteinase-3) or secretory leukocyte protease inhibitor (an inhibitor of elastase but not of proteinase-3) abolished IL-8-induced GC degranulation, implicating elastase.	ici 200,	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
9665313-0	1998	Stimulation of monocyte interleukin-8 by lipid peroxidation products: a mechanism for alcohol-induced liver injury.	Alcohols	86-93	C-X-C motif chemokine ligand 8	Homo sapiens	24-37
9665313-3	1998	Peroxidized fatty acids (arachidonic and linolenic) as well as microsomal membranes stimulated IL-8 production by peripheral blood monocytes whereas ethanol and acetaldehyde did not.	Fatty Acids	12-23	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
9665313-4	1998	Hydrocortisone (5 microg/ml) prevented the IL-8 stimulation by peroxidized fatty acids.	Hydrocortisone	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
9665313-4	1998	Hydrocortisone (5 microg/ml) prevented the IL-8 stimulation by peroxidized fatty acids.	Fatty Acids	75-86	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
9705848-5	1998	The specific p38 MAP kinase inhibitor SB 203580 inhibited cooling and rewarming-induced IL-8 expression, indicating that cooling and rewarming-induced IL-8 expression in BEC was mediated through p38 MAP kinase-dependent pathway.	SB 203580	38-47	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
9705848-5	1998	The specific p38 MAP kinase inhibitor SB 203580 inhibited cooling and rewarming-induced IL-8 expression, indicating that cooling and rewarming-induced IL-8 expression in BEC was mediated through p38 MAP kinase-dependent pathway.	SB 203580	38-47	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
9665313-5	1998	Ethanol-induced lipid peroxidation may secondarily further alcohol-induced liver injury through IL-8 chemotaxis of neutrophils.	Ethanol	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
9698598-0	1998	Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	114-120	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
9665313-5	1998	Ethanol-induced lipid peroxidation may secondarily further alcohol-induced liver injury through IL-8 chemotaxis of neutrophils.	Alcohols	59-66	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
9727645-6	1998	Both prednisone and a prostaglandin analog were effective in downregulating TNF and interleukin-8 production.	Prednisone	5-15	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
9727645-6	1998	Both prednisone and a prostaglandin analog were effective in downregulating TNF and interleukin-8 production.	Prostaglandins	22-35	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
9698598-4	1998	However, pretreatment of the cells with the proteasome inhibitor N-cbz-Leu-Leu-leucinal (MG-132, 10 microM) reversed the effects of TNF-alpha on IL-8 release from A549 cells (as determined with an enzyme-linked immunosorbent assay [ELISA]) and on IL-8 gene transcription (as determined with reporter-gene assays).	n-cbz	65-70	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
9698598-4	1998	However, pretreatment of the cells with the proteasome inhibitor N-cbz-Leu-Leu-leucinal (MG-132, 10 microM) reversed the effects of TNF-alpha on IL-8 release from A549 cells (as determined with an enzyme-linked immunosorbent assay [ELISA]) and on IL-8 gene transcription (as determined with reporter-gene assays).	n-cbz	65-70	C-X-C motif chemokine ligand 8	Homo sapiens	247-251
9698598-4	1998	However, pretreatment of the cells with the proteasome inhibitor N-cbz-Leu-Leu-leucinal (MG-132, 10 microM) reversed the effects of TNF-alpha on IL-8 release from A549 cells (as determined with an enzyme-linked immunosorbent assay [ELISA]) and on IL-8 gene transcription (as determined with reporter-gene assays).	Leucine	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
9698598-4	1998	However, pretreatment of the cells with the proteasome inhibitor N-cbz-Leu-Leu-leucinal (MG-132, 10 microM) reversed the effects of TNF-alpha on IL-8 release from A549 cells (as determined with an enzyme-linked immunosorbent assay [ELISA]) and on IL-8 gene transcription (as determined with reporter-gene assays).	Leucine	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	247-251
9756185-3	1998	Further to these observations we report on the inhibition by theophylline of NF-kappaB, a key transcription factor found in human purified mast cells, which plays a role in the transcription of TNF alpha, GM-CSF, and IL-8 within this cell.	Theophylline	61-73	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
9723955-0	1998	Regulation of RANTES and IL-8 production in normal human dermal fibroblasts by active vitamin D3 (tacalcitol).	Cholecalciferol	86-96	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
9723955-0	1998	Regulation of RANTES and IL-8 production in normal human dermal fibroblasts by active vitamin D3 (tacalcitol).	1 alpha,24-dihydroxyvitamin D3	98-108	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
9723955-6	1998	Tacalcitol suppressed RANTES and IL-8 production dose-dependently at concentrations between 10(-12) M and 10(-7) M. 3.	1 alpha,24-dihydroxyvitamin D3	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
9723955-8	1998	Tacalcitol decreased IL-8 production dose-dependently as observed in the TNF-alpha-treated cells.	1 alpha,24-dihydroxyvitamin D3	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
9723955-11	1998	Three active vitamin D3 compounds, tacalcitol, 1alpha,25-dihydroxyvitamin D3 and MC903 (calcipotriol), inhibited the production of RANTES and IL-8, with very similar potencies.	Cholecalciferol	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
9723955-11	1998	Three active vitamin D3 compounds, tacalcitol, 1alpha,25-dihydroxyvitamin D3 and MC903 (calcipotriol), inhibited the production of RANTES and IL-8, with very similar potencies.	1 alpha,24-dihydroxyvitamin D3	35-45	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
9723955-11	1998	Three active vitamin D3 compounds, tacalcitol, 1alpha,25-dihydroxyvitamin D3 and MC903 (calcipotriol), inhibited the production of RANTES and IL-8, with very similar potencies.	Calcitriol	47-76	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
9723955-11	1998	Three active vitamin D3 compounds, tacalcitol, 1alpha,25-dihydroxyvitamin D3 and MC903 (calcipotriol), inhibited the production of RANTES and IL-8, with very similar potencies.	calcipotriene	81-86	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
9723955-11	1998	Three active vitamin D3 compounds, tacalcitol, 1alpha,25-dihydroxyvitamin D3 and MC903 (calcipotriol), inhibited the production of RANTES and IL-8, with very similar potencies.	calcipotriene	88-100	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
9723955-13	1998	Cyclosporin A significantly stimulated RANTES production at 10(-6) M and IL-8 production at 10(-7) M and 10(-6) M. 5.	Cyclosporine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
9756186-4	1998	In this study we investigated the ability of theophylline to inhibit the release of preformed GM-CSF and IL-8 from eosinophils in vitro, as these cytokines may serve an autocrine function in eosinophil survival in vivo.	Theophylline	45-57	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
9723671-0	1998	Diisocyanate antigen-enhanced production of monocyte chemoattractant protein-1, IL-8, and tumor necrosis factor-alpha by peripheral mononuclear cells of workers with occupational asthma.	4,4'-diphenylmethane diisocyanate	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	80-117
9710230-4	1998	TIL matrix invasion elicited by TC is inhibited by the addition of neutralizing antisera specific for IL-8 and MCP-1, demonstrating the direct relationship between chemokine release by TC and TIL invasion.	Technetium	32-34	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
9710230-4	1998	TIL matrix invasion elicited by TC is inhibited by the addition of neutralizing antisera specific for IL-8 and MCP-1, demonstrating the direct relationship between chemokine release by TC and TIL invasion.	Technetium	185-187	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
9719033-6	1998	The IL-8 mRNA accumulation in response to P. intermedia LPS was inhibited by tosylphenyl-alanyl chloromethyl-ketone, an inhibitor of NF-kappaB activation, although the NF-kappaB activation itself was not altered by IFN-gamma.	Tosylphenylalanyl Chloromethyl Ketone	77-115	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
9726445-5	1998	Using human Hep G2 cells, it was demonstrated that, in contrast to lipopolysaccharides (LPS), both tumor necrosis factor-alpha (TNF-beta) and H2O2 are potent inducers of IL-8, presumably acting via protein kinase C (PKC)-dependent pathways.	Hydrogen Peroxide	142-146	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
9712106-9	1998	Inhibition of NO synthesis with the competitive inhibitor NG-monomethyl-L-arginine (L-NMMA) led to enhancement of IL-6, IL-8, and PGE2 production stimulated by either IL-1beta alone or in combination with LPS, whereas the inhibition of proteoglycan production by IL-1beta was not modified by L-NMMA.	omega-N-Methylarginine	58-82	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
9726445-7	1998	Both IL-8 and MIP-2 secretion were inhibited, although to varying degrees, by such antioxidants as TMTU, DMSO, catalase, and N-acetylcysteine.	tetramethylthiourea	99-103	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
9726445-7	1998	Both IL-8 and MIP-2 secretion were inhibited, although to varying degrees, by such antioxidants as TMTU, DMSO, catalase, and N-acetylcysteine.	Dimethyl Sulfoxide	105-109	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
9726445-7	1998	Both IL-8 and MIP-2 secretion were inhibited, although to varying degrees, by such antioxidants as TMTU, DMSO, catalase, and N-acetylcysteine.	Acetylcysteine	125-141	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
9726445-8	1998	Furthermore, in vitro TNF-alpha neutralization experiments and transfection of Hep G2 cells with an IL-8 construct confirmed that TNF-alpha and H2O2 directly stimulate IL-8 secretion.	Hydrogen Peroxide	144-148	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
9726445-8	1998	Furthermore, in vitro TNF-alpha neutralization experiments and transfection of Hep G2 cells with an IL-8 construct confirmed that TNF-alpha and H2O2 directly stimulate IL-8 secretion.	Hydrogen Peroxide	144-148	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
9712106-0	1998	Nitric oxide downregulates interleukin 1beta (IL-1beta) stimulated IL-6, IL-8, and prostaglandin E2 production by human chondrocytes.	Nitric Oxide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
9712106-9	1998	Inhibition of NO synthesis with the competitive inhibitor NG-monomethyl-L-arginine (L-NMMA) led to enhancement of IL-6, IL-8, and PGE2 production stimulated by either IL-1beta alone or in combination with LPS, whereas the inhibition of proteoglycan production by IL-1beta was not modified by L-NMMA.	omega-N-Methylarginine	84-90	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
9687567-8	1998	Of the mRNAs tested, only those encoding monocyte chemotactic protein-1 (approximately 2-fold over basal) and interleukin-8 (approximately 6-fold over basal) are induced by histamine; both of these responses are suppressed by CsA and FK506.	Histamine	173-182	C-X-C motif chemokine ligand 8	Homo sapiens	110-123
9690225-9	1998	RESULTS: Compared to the control group, PBMC from uremic patients on conservative therapy and treated by CU showed a clear reduction in the cytokine release, while PMMA and PA membranes were able to normalize IL-6, IL-8 and MCP-1 protein concentration, which had been reduced by CU treatment.	Nylons	173-175	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
9690225-9	1998	RESULTS: Compared to the control group, PBMC from uremic patients on conservative therapy and treated by CU showed a clear reduction in the cytokine release, while PMMA and PA membranes were able to normalize IL-6, IL-8 and MCP-1 protein concentration, which had been reduced by CU treatment.	cuprammonium cellulose	105-107	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
9690225-9	1998	RESULTS: Compared to the control group, PBMC from uremic patients on conservative therapy and treated by CU showed a clear reduction in the cytokine release, while PMMA and PA membranes were able to normalize IL-6, IL-8 and MCP-1 protein concentration, which had been reduced by CU treatment.	Polymethyl Methacrylate	164-168	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
9687567-8	1998	Of the mRNAs tested, only those encoding monocyte chemotactic protein-1 (approximately 2-fold over basal) and interleukin-8 (approximately 6-fold over basal) are induced by histamine; both of these responses are suppressed by CsA and FK506.	Cyclosporine	226-229	C-X-C motif chemokine ligand 8	Homo sapiens	110-123
9687567-8	1998	Of the mRNAs tested, only those encoding monocyte chemotactic protein-1 (approximately 2-fold over basal) and interleukin-8 (approximately 6-fold over basal) are induced by histamine; both of these responses are suppressed by CsA and FK506.	Tacrolimus	234-239	C-X-C motif chemokine ligand 8	Homo sapiens	110-123
9704773-4	1998	Correlations were found between hyaluronic acid concentrations and interleukin-1beta (P = .018) and interleukin-8 (P = .003) concentrations in cervical mucus.	Hyaluronic Acid	32-47	C-X-C motif chemokine ligand 8	Homo sapiens	100-113
9828857-12	1998	IL-8+ cells were less prominent in steroid treated patients than in patients not receiving treatment (30 cells/mm2 versus 60 cells/mm2, p &lt; 0.05).	Steroids	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9670044-4	1998	Met-enkephalin, as well as morphine, inhibited IL-8-induced chemotaxis of human neutrophils and macrophage inflammatory protein (MIP)-1alpha, regulated upon activation, normal T expressed and secreted (RANTES), and monocyte chemoattractant protein 1, but not MIP-1beta-induced chemotaxis of human monocytes.	Morphine	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
9707512-6	1998	IL-8 and MIP-2 secretion induced either by the metals or H2O2 were inhibited by antioxidants such as tetramethyl-thiourea and N-acetyl-cysteine.	Hydrogen Peroxide	57-61	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9707512-6	1998	IL-8 and MIP-2 secretion induced either by the metals or H2O2 were inhibited by antioxidants such as tetramethyl-thiourea and N-acetyl-cysteine.	tetramethylthiourea	101-121	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9707512-6	1998	IL-8 and MIP-2 secretion induced either by the metals or H2O2 were inhibited by antioxidants such as tetramethyl-thiourea and N-acetyl-cysteine.	Acetylcysteine	126-143	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9655727-14	1998	These data suggest that exposure to fuel-oil ash results in acute upper airway inflammation, potentially mediated by increased IL-8 levels and the recruitment and activation of polymorphonuclear leukocytes.	Oils	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
9704773-5	1998	Cytokines (especially interleukin-8) stimulated hyaluronic acid production by cultured cervical fibroblasts.	Hyaluronic Acid	48-63	C-X-C motif chemokine ligand 8	Homo sapiens	22-35
9704790-8	1998	In placentas delivered spontaneously, onapristone significantly increased production of interleukin 8 (P &lt; .05), whereas in those from cesarean deliveries lilopristone caused a significant increase in production (P &lt; .05).	onapristone	38-49	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
9692902-6	1998	GCP-2 desensitized the calcium increase induced by IL-8 in both CXCR1-transfected and CXCR2-transfected cells, but ENA-78 only affected the IL-8-induced calcium response in CXCR2-transfectants.	Calcium	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
9698090-2	1998	Previously, we showed that the protein kinase inhibitor staurosporine potentiates IL-1-stimulated IL-8 production in human keratinocytes.	Staurosporine	56-69	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
9698090-3	1998	Moreover, recent studies by other investigators demonstrated that staurosporine treatment alone results in a concentration-dependent increase in IL-8 mRNA and protein production.	Staurosporine	66-79	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
9698090-6	1998	The ability of staurosporine to activate NF-kappaB was investigated further, using luciferase reporters under the control of the HIV-LTR or IL-8 core promoter transfected into human U937 cells.	Staurosporine	15-28	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
9692902-6	1998	GCP-2 desensitized the calcium increase induced by IL-8 in both CXCR1-transfected and CXCR2-transfected cells, but ENA-78 only affected the IL-8-induced calcium response in CXCR2-transfectants.	Calcium	153-160	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
9738983-9	1998	Intracellular H2O2 production and IL-8 release were transiently induced immediately after treatment with platinum compounds, leading to IL-1 release when H2O2 production was eliminated.	Platinum	105-113	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
9665286-9	1998	Go6976, which inhibits certain isoforms of PKC, inhibited production of both IL-8 and TNF-alpha.	Go 6976	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
9722036-0	1998	Effect of L-NAME, an inhibitor of nitric oxide synthesis, on plasma levels of IL-6, IL-8, TNF alpha and nitrite/nitrate in human septic shock.	NG-Nitroarginine Methyl Ester	10-16	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
9749865-6	1998	Hydrocortisone significantly suppressed the production of IL-6, IL-8, and GM-CSF by TCCs from AH of VKH patients.	Hydrocortisone	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
9749865-7	1998	Tacrolimus also significantly suppressed the production of IL-8 and GM-CSF by the TCCs.	Tacrolimus	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
9738983-9	1998	Intracellular H2O2 production and IL-8 release were transiently induced immediately after treatment with platinum compounds, leading to IL-1 release when H2O2 production was eliminated.	Hydrogen Peroxide	154-158	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
9624135-0	1998	Defining the interleukin-8-binding domain of heparan sulfate.	Heparitin Sulfate	45-60	C-X-C motif chemokine ligand 8	Homo sapiens	13-26
10070569-4	1998	Results showed that a 48 h O2 exposure was associated with two distinct patterns of response: a decrease in TNF-alpha, IL-1 beta and IL-6 expression, and an increase in IL-8.	Oxygen	27-29	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
10070569-6	1998	We confirmed that a 48 h O2 exposure led to similar changes with a decrease in TNF-alpha, IL-1 beta and IL-6 production and an increase in IL-8.	Oxygen	25-27	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
11189515-0	1998	[Expression of interleukin-8 and its receptor in acute promyelocytic leukemia under all-trans retinoic acid treatment].	Tretinoin	94-107	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
11189515-1	1998	OBJECTIVE: To evaluate the clinical significance of expression of interleukin-(IL-8) and its type A receptor(IL-8RA) in acute promyelocytic leukemia(APL) patients under all trans-retinoic acid(ATRA) induction.	Tretinoin	173-192	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
11189515-1	1998	OBJECTIVE: To evaluate the clinical significance of expression of interleukin-(IL-8) and its type A receptor(IL-8RA) in acute promyelocytic leukemia(APL) patients under all trans-retinoic acid(ATRA) induction.	Tretinoin	193-197	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
11189515-9	1998	CONCLUSION: ATRA inhibited IL-8 secretion of APL cells while increased the expression of IL-8RA.	Tretinoin	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
9624135-1	1998	Interleukin-8, a member of the CXC chemokine family, has been shown to bind to glycosaminoglycans.	Glycosaminoglycans	79-97	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
9624135-3	1998	By using selectively modified heparin and heparan sulfate fragments in a nitrocellulose filter trapping system, we have analyzed sequence requirements for interleukin-8 binding to heparin/heparan sulfate.	Heparin	180-187	C-X-C motif chemokine ligand 8	Homo sapiens	155-168
9624135-3	1998	By using selectively modified heparin and heparan sulfate fragments in a nitrocellulose filter trapping system, we have analyzed sequence requirements for interleukin-8 binding to heparin/heparan sulfate.	Heparitin Sulfate	188-203	C-X-C motif chemokine ligand 8	Homo sapiens	155-168
9624135-4	1998	We demonstrate that the affinity of a monomeric interleukin-8 molecule for heparin/heparan sulfate is too weak to allow binding at physiological ionic strength, whereas the dimeric form of the protein mediates binding to two sulfated domains of heparan sulfate.	Heparin	75-82	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
9624135-4	1998	We demonstrate that the affinity of a monomeric interleukin-8 molecule for heparin/heparan sulfate is too weak to allow binding at physiological ionic strength, whereas the dimeric form of the protein mediates binding to two sulfated domains of heparan sulfate.	Heparitin Sulfate	83-98	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
9624135-4	1998	We demonstrate that the affinity of a monomeric interleukin-8 molecule for heparin/heparan sulfate is too weak to allow binding at physiological ionic strength, whereas the dimeric form of the protein mediates binding to two sulfated domains of heparan sulfate.	Heparitin Sulfate	245-260	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
9624135-6	1998	Binding to interleukin-8 correlates with the occurrence of the di-O-sulfated disaccharide unit -IdceA(2-OSO3)-GlcNSO3(6-OSO3)-.	di-o-sulfated disaccharide	63-89	C-X-C motif chemokine ligand 8	Homo sapiens	11-24
9624135-6	1998	Binding to interleukin-8 correlates with the occurrence of the di-O-sulfated disaccharide unit -IdceA(2-OSO3)-GlcNSO3(6-OSO3)-.	2-oso3	102-108	C-X-C motif chemokine ligand 8	Homo sapiens	11-24
9624135-6	1998	Binding to interleukin-8 correlates with the occurrence of the di-O-sulfated disaccharide unit -IdceA(2-OSO3)-GlcNSO3(6-OSO3)-.	glcnso3	110-117	C-X-C motif chemokine ligand 8	Homo sapiens	11-24
9624135-6	1998	Binding to interleukin-8 correlates with the occurrence of the di-O-sulfated disaccharide unit -IdceA(2-OSO3)-GlcNSO3(6-OSO3)-.	6-oso3	118-124	C-X-C motif chemokine ligand 8	Homo sapiens	11-24
9609743-0	1998	Leukotriene B4 mediates histamine induction of NF-kappaB and IL-8 in human bronchial epithelial cells.	Leukotriene B4	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
9660302-8	1998	In the first set of experiments, IL-8 gene reporter constructs were used to transiently transfect a derivative (MVh2E1-9) of the HepG2 cell line which expresses P-4502E1 and metabolizes ethanol.	Ethanol	186-193	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
9660302-10	1998	This system may be useful to assess the effects of ethanol on TNF-induced hepatocyte IL-8 production.	Ethanol	51-58	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
9609743-0	1998	Leukotriene B4 mediates histamine induction of NF-kappaB and IL-8 in human bronchial epithelial cells.	Histamine	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
9609743-1	1998	In 16HBE transformed human bronchial epithelial cells, histamine stimulated interleukin (IL)-8 mRNA and protein secretion, and this histamine stimulation was inhibited by the H1-receptor antagonist diphenhydramine (DPH), by the inhibitor of 5-lipoxygenase-activating protein (FLAP) MK-886, by the 5-lipoxygenase inhibitor Zileuton, and by dexamethasone.	Histamine	55-64	C-X-C motif chemokine ligand 8	Homo sapiens	76-94
9609743-1	1998	In 16HBE transformed human bronchial epithelial cells, histamine stimulated interleukin (IL)-8 mRNA and protein secretion, and this histamine stimulation was inhibited by the H1-receptor antagonist diphenhydramine (DPH), by the inhibitor of 5-lipoxygenase-activating protein (FLAP) MK-886, by the 5-lipoxygenase inhibitor Zileuton, and by dexamethasone.	Diphenhydramine	198-213	C-X-C motif chemokine ligand 8	Homo sapiens	76-94
9609743-1	1998	In 16HBE transformed human bronchial epithelial cells, histamine stimulated interleukin (IL)-8 mRNA and protein secretion, and this histamine stimulation was inhibited by the H1-receptor antagonist diphenhydramine (DPH), by the inhibitor of 5-lipoxygenase-activating protein (FLAP) MK-886, by the 5-lipoxygenase inhibitor Zileuton, and by dexamethasone.	Diphenhydramine	215-218	C-X-C motif chemokine ligand 8	Homo sapiens	76-94
9609743-3	1998	Histamine stimulated IL-8 luciferase reporter gene activity that was inhibited with DPH, dexamethasone, MK-886 and L-655,238, and Zileuton.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
9620522-0	1998	The effect of midazolam and propofol on interleukin-8 from human polymorphonuclear leukocytes.	Midazolam	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
9609743-3	1998	Histamine stimulated IL-8 luciferase reporter gene activity that was inhibited with DPH, dexamethasone, MK-886 and L-655,238, and Zileuton.	Diphenhydramine	84-87	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
9620522-0	1998	The effect of midazolam and propofol on interleukin-8 from human polymorphonuclear leukocytes.	Propofol	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
9609743-3	1998	Histamine stimulated IL-8 luciferase reporter gene activity that was inhibited with DPH, dexamethasone, MK-886 and L-655,238, and Zileuton.	Dexamethasone	89-102	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
9620522-6	1998	Lipopolysaccharide increased extracellular accumulation of interleukin-8, which was suppressed by both propofol (P = 0.025) and midazolam (P = 0.028).	Propofol	103-111	C-X-C motif chemokine ligand 8	Homo sapiens	59-72
9620522-6	1998	Lipopolysaccharide increased extracellular accumulation of interleukin-8, which was suppressed by both propofol (P = 0.025) and midazolam (P = 0.028).	Midazolam	128-137	C-X-C motif chemokine ligand 8	Homo sapiens	59-72
9609743-3	1998	Histamine stimulated IL-8 luciferase reporter gene activity that was inhibited with DPH, dexamethasone, MK-886 and L-655,238, and Zileuton.	zileuton	130-138	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
9620522-8	1998	Northern blot analysis also revealed increased IL-8 mRNA levels in the presence of both midazolam and propofol, which was confirmed by molecular imaging.	Midazolam	88-97	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
9609743-4	1998	The inhibition of IL-8 transcription and protein secretion by FLAP inhibitors and Zileuton was reversed with exogenous LTB4.	zileuton	82-90	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
9620522-8	1998	Northern blot analysis also revealed increased IL-8 mRNA levels in the presence of both midazolam and propofol, which was confirmed by molecular imaging.	Propofol	102-110	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
9620522-12	1998	We investigated the effect of propofol and midazolam on interleukin-8, a neutrophil chemotactic agent in human neutrophils.	Midazolam	43-52	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
9609743-5	1998	There was increased IL-8 nuclear factor-kappaB (NF-kappaB) DNA-binding activity after histamine stimulation, and this was inhibited by DPH and MK-886.	Histamine	86-95	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
9620522-14	1998	This suggests that propofol and midazolam alter interleukin-8 secretion from cells.	Propofol	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
9609743-5	1998	There was increased IL-8 nuclear factor-kappaB (NF-kappaB) DNA-binding activity after histamine stimulation, and this was inhibited by DPH and MK-886.	Diphenhydramine	135-138	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
9620522-14	1998	This suggests that propofol and midazolam alter interleukin-8 secretion from cells.	Midazolam	32-41	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
9609743-5	1998	There was increased IL-8 nuclear factor-kappaB (NF-kappaB) DNA-binding activity after histamine stimulation, and this was inhibited by DPH and MK-886.	MK-886	143-149	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
9624502-2	1998	Roxithromycin suppressed production of interleukin 8 (IL-8), IL-6, and granulocyte-macrophage colony-stimulating factor.	Roxithromycin	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
9609743-7	1998	Thus histamine stimulation of bronchial epithelial cells involves binding at H1 receptors, production of LTB4, activation of NF-kappaB and increased expression of IL-8.	Histamine	5-14	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
9620068-10	1998	Furthermore, pyrrolidine dithiocarbamate, a specific inhibitor of NF-kappaB activation, prevented the induction of the IL-8 gene, but not that of the VEGF gene.	pyrrolidine dithiocarbamic acid	13-40	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
9624502-2	1998	Roxithromycin suppressed production of interleukin 8 (IL-8), IL-6, and granulocyte-macrophage colony-stimulating factor.	Roxithromycin	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
9683032-12	1998	CONCLUSIONS: These studies identify requirements for selectins, beta2 integrins, IL-1 and a rat chemokine(s) similar to human IL-8 for neutrophil recruitment during glycogen-induced peritonitis.	Glycogen	165-173	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
9605168-9	1998	Chelerythrin inhibited both the IL-8 and PMA activation of alpha L beta 2 and alpha V beta 3.	chelerythrin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
9648711-6	1998	The specific p38 MAP kinase inhibitor, SB 203580, completely inhibited TNF-alpha-, IL-1alpha-, or PAF-induced IL-8 protein and mRNA expression in BECs.	SB 203580	39-48	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
9629951-7	1998	There were significant and inverse relationships between the availability of plasma tryptophan and serum IL-1RA, IL-6 and IL-8.	Tryptophan	84-94	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
9581864-7	1998	Tiludronate suppressed the choline formation induced by NaF, known as an activator of heterotrimeric GTP-binding protein.	tiludronic acid	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
9581864-7	1998	Tiludronate suppressed the choline formation induced by NaF, known as an activator of heterotrimeric GTP-binding protein.	Choline	27-34	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
9581864-7	1998	Tiludronate suppressed the choline formation induced by NaF, known as an activator of heterotrimeric GTP-binding protein.	Guanosine Triphosphate	101-104	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
9581864-9	1998	Tiludronate significantly inhibited the NaF-induced IL-6 secretion in human osteoblastic osteosarcoma Saos-2 cells.	tiludronic acid	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
9665590-3	1998	NF-kappaB involvement was suggested by the finding that pyrrolidinedithiocarbamate, a known inhibitor of NF-kappaB activation, blocked LPS- and IL-1beta-induced IL-8 production.	pyrrolidine dithiocarbamic acid	56-82	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
9749983-5	1998	While staurosporin and genistein inhibited both Yersinia invasion and Yersinia-triggered IL-8 secretion, wortmannin, an inhibitor of the phosphatidylinositol-3-phosphate kinase (PI3-K), blocked invasion of Y. enterocolitica into HeLa cells but did not show any effect on IL-8 secretion.	Staurosporine	6-18	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
9749983-5	1998	While staurosporin and genistein inhibited both Yersinia invasion and Yersinia-triggered IL-8 secretion, wortmannin, an inhibitor of the phosphatidylinositol-3-phosphate kinase (PI3-K), blocked invasion of Y. enterocolitica into HeLa cells but did not show any effect on IL-8 secretion.	Genistein	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
9677630-11	1998	Steroid therapy diminishes the proteins, GM-CSF.RANTES and IL-8 as well as the messengers IL-4, IL-13 and IL-5.	Steroids	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
9625374-0	1998	Effect of dehydroepiandrosterone sulfate on interleukin-8 receptor during cervical ripening.	Dehydroepiandrosterone Sulfate	10-40	C-X-C motif chemokine ligand 8	Homo sapiens	44-57
9629232-5	1998	Furthermore, we observed that preincubation of monocytes or neutrophils with MET or morphine prevented their subsequent chemotaxis in response to chemokines (MIP1 alpha or IL-8).	Morphine	84-92	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
9645599-2	1998	Interleukin-8 binds to the glycosaminoglycan (GAG) heparin and the protease inhibitor alpha2-macroglobulin, molecules which regulate the function of a number of cytokines.	glycosaminoglycan (gag) heparin	27-58	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
9645599-3	1998	Heparan sulphate was previously shown to enhance neutrophil chemotactic responses to IL-8.	Heparitin Sulfate	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
9645599-4	1998	OBJECTIVE: The purpose of this study was to investigate the effect of heparin, heparan sulphate and alpha2-macroglobulin on IL-8 binding to neutrophils and subsequent functional effects in vitro.	Heparin	70-77	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
9645599-4	1998	OBJECTIVE: The purpose of this study was to investigate the effect of heparin, heparan sulphate and alpha2-macroglobulin on IL-8 binding to neutrophils and subsequent functional effects in vitro.	Heparitin Sulfate	79-95	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
9645599-7	1998	RESULTS: Heparin, but not heparan sulphate, inhibited the binding of 125I-IL-8 to neutrophils (IC50=26 microg/mL) and IL-8 induced neutrophil chemotactic responses (IC50=4 microg/mL).	Heparin	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
9645599-7	1998	RESULTS: Heparin, but not heparan sulphate, inhibited the binding of 125I-IL-8 to neutrophils (IC50=26 microg/mL) and IL-8 induced neutrophil chemotactic responses (IC50=4 microg/mL).	Heparin	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
9645599-8	1998	The specific inhibitory effect of heparin was apparently due to an interaction with IL-8 which was charge-dependent, since dextran sulphate had a greater inhibitory effect on chemotactic responses (IC50=2 microg/mL) and FITC-heparin did not bind to neutrophils.	Heparin	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
9645599-8	1998	The specific inhibitory effect of heparin was apparently due to an interaction with IL-8 which was charge-dependent, since dextran sulphate had a greater inhibitory effect on chemotactic responses (IC50=2 microg/mL) and FITC-heparin did not bind to neutrophils.	Dextran Sulfate	123-139	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
9645599-8	1998	The specific inhibitory effect of heparin was apparently due to an interaction with IL-8 which was charge-dependent, since dextran sulphate had a greater inhibitory effect on chemotactic responses (IC50=2 microg/mL) and FITC-heparin did not bind to neutrophils.	fitc-heparin	220-232	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
9645599-9	1998	The heparin-induced inhibition of IL-8 binding and chemotactic responses was reversed in a dose-dependent manner in the presence of alpha2-macroglobulin.	Heparin	4-11	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
9657419-3	1998	There were significant correlations between the availability of tryptophan to the brain and serum IL-6, IL-8 and IL-1RA (all negative) and CC16 (positive).	Tryptophan	64-74	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
9625374-1	1998	We investigated the effects of dehydroepiandrosterone sulfate (DHA-S) on the production of interleukin-8 (IL-8) and expression of the interleukin-8 receptor (IL-8 R) in human cervical tissue.	Dehydroepiandrosterone Sulfate	31-61	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
9625374-1	1998	We investigated the effects of dehydroepiandrosterone sulfate (DHA-S) on the production of interleukin-8 (IL-8) and expression of the interleukin-8 receptor (IL-8 R) in human cervical tissue.	Dehydroepiandrosterone Sulfate	63-68	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
9591504-7	1998	The effect of IL-8 on cell proliferation was examined by tetrazolium bromide and thymidine incorporation.	tetrazolium bromide	57-76	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
9625374-1	1998	We investigated the effects of dehydroepiandrosterone sulfate (DHA-S) on the production of interleukin-8 (IL-8) and expression of the interleukin-8 receptor (IL-8 R) in human cervical tissue.	Dehydroepiandrosterone Sulfate	63-68	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
9591504-7	1998	The effect of IL-8 on cell proliferation was examined by tetrazolium bromide and thymidine incorporation.	Thymidine	81-90	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
9625374-2	1998	DHA-S increased the levels of IL-8 in cultured human cervical fibroblasts and in the supernatant in a time- and dose-dependent manner.	Dehydroepiandrosterone Sulfate	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
9625374-3	1998	DHA-S induced IL-8 and IL-8 R expression in human cervical fibroblasts and human pregnant cervical tissue at term in a dose-dependent manner.	Dehydroepiandrosterone Sulfate	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
9625374-3	1998	DHA-S induced IL-8 and IL-8 R expression in human cervical fibroblasts and human pregnant cervical tissue at term in a dose-dependent manner.	Dehydroepiandrosterone Sulfate	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
9625374-5	1998	However, dehydroepiandrosterone (DHA) only slightly induced the production of IL-8 and the expression of IL-8 R in the same cells and tissue.	Dehydroepiandrosterone	9-31	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
9625374-5	1998	However, dehydroepiandrosterone (DHA) only slightly induced the production of IL-8 and the expression of IL-8 R in the same cells and tissue.	Dehydroepiandrosterone	9-31	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
9625374-5	1998	However, dehydroepiandrosterone (DHA) only slightly induced the production of IL-8 and the expression of IL-8 R in the same cells and tissue.	Dehydroepiandrosterone	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
9625374-5	1998	However, dehydroepiandrosterone (DHA) only slightly induced the production of IL-8 and the expression of IL-8 R in the same cells and tissue.	Dehydroepiandrosterone	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
9625374-6	1998	These results suggest that DHA-S up-regulates the autocrine system of IL-8 through the expression of IL-8 R.	Dehydroepiandrosterone Sulfate	27-32	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
9625374-6	1998	These results suggest that DHA-S up-regulates the autocrine system of IL-8 through the expression of IL-8 R.	Dehydroepiandrosterone Sulfate	27-32	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
9716261-0	1998	Fosfomycin (FOM: 1 R-2S-epoxypropylphosphonic acid) suppress the production of IL-8 from monocytes via the suppression of neutrophil function.	Fosfomycin	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
9716261-0	1998	Fosfomycin (FOM: 1 R-2S-epoxypropylphosphonic acid) suppress the production of IL-8 from monocytes via the suppression of neutrophil function.	Fosfomycin	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
9716261-0	1998	Fosfomycin (FOM: 1 R-2S-epoxypropylphosphonic acid) suppress the production of IL-8 from monocytes via the suppression of neutrophil function.	Fosfomycin	17-50	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
9716261-1	1998	We investigated the influence of fosfomycin (FOM) on the production and the mRNA expression of interleukin-8 (IL-8) by monocytes.	Fosfomycin	33-43	C-X-C motif chemokine ligand 8	Homo sapiens	95-108
9716261-1	1998	We investigated the influence of fosfomycin (FOM) on the production and the mRNA expression of interleukin-8 (IL-8) by monocytes.	Fosfomycin	33-43	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
9716261-2	1998	In the incubation of whole blood stimulated by N-Formyl-Met-Leu-Phe (FMLP), FOM significantly suppressed the production and the mRNA expression of IL-8 by monocytes and its inhibitory action was concentration-dependent (FOM: 50-200 microg/ml).	N-Formylmethionine Leucyl-Phenylalanine	47-67	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
9574558-10	1998	These findings suggest that TNF-alpha down-regulates CXCR2 expression on PMNs and modulates IL-8-induced biologic responses, leading to the intravascular retention of PMNs with an enhanced production of reactive oxygen metabolites.	Oxygen	212-218	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
9713630-7	1998	It was found that CsA inhibits basal secretion of TNF-alpha and IL-8 at 20 and 200 ng ml-1.	Cyclosporine	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
9604183-0	1998	Tumor necrosis factor-alpha and interleukin-8 release from U937 human mononuclear cells exposed to zinc oxide in vitro.	Zinc Oxide	99-109	C-X-C motif chemokine ligand 8	Homo sapiens	32-45
9604183-2	1998	Respiratory exposure to zinc oxide results in metal fume fever, a flu-like illness characterized by dose-dependent increases in pulmonary tumor necrosis factor-alpha (TNF) and interleukin-8 (IL-8).	Zinc Oxide	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	176-189
9604183-2	1998	Respiratory exposure to zinc oxide results in metal fume fever, a flu-like illness characterized by dose-dependent increases in pulmonary tumor necrosis factor-alpha (TNF) and interleukin-8 (IL-8).	Zinc Oxide	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
9604183-2	1998	Respiratory exposure to zinc oxide results in metal fume fever, a flu-like illness characterized by dose-dependent increases in pulmonary tumor necrosis factor-alpha (TNF) and interleukin-8 (IL-8).	Metals	46-51	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
9604183-4	1998	Cell culture supernatant TNF and IL-8 was measured after 3, 8, and 24 hours of exposure to zinc oxide in varying concentrations.	Zinc Oxide	91-101	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
9604183-8	1998	These data demonstrate that in vitro zinc oxide exposure stimulates U937 mononuclear cells to release TNF and IL-8 consistent with in vivo observations in metal fume fever.	Zinc Oxide	37-47	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
11774414-1	1998	OBJECTIVE: To identify the nature of the IL-8 inhibitor(s) in gingival crevicul fluid (GCF).	3-[3-[3-[(4~{s})-6-Azanyl-5-Cyano-3-Methyl-4-Propan-2-Yl-2~{h}-Pyrano[2,3-C]pyrazol-4-Yl]-5-(Trifluoromethyl)phenyl]phenyl]propanoic Acid	87-90	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
9564285-13	1998	The removal of IL-6 and IL-8 by CVVH after initial stimulation correlates with clinical improvement, which was demonstrated by significantly improved oxygenation and hemodynamics from 2 hours after the initiation of CVVH onward.	cvvh	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
11774414-7	1998	RESULTS: (1) IL-8 level in the PMSF-added samples were significantly greater than that in the control group(3.01 mg/L +/- 5.79 mg/L vs 0.05 mg/L +/- 0.15 mg/L, P &lt; 0.001).	Phenylmethylsulfonyl Fluoride	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
11774414-8	1998	(2) The mean value of anti-IL-8 IgG in GCF was greater than that of negative control +3 x s. CONCLUSION: A serine protease which can "cleave" IL-8 exists in GCF and GCF from AP sites contain auto-antibody against IL-8.	3-[3-[3-[(4~{s})-6-Azanyl-5-Cyano-3-Methyl-4-Propan-2-Yl-2~{h}-Pyrano[2,3-C]pyrazol-4-Yl]-5-(Trifluoromethyl)phenyl]phenyl]propanoic Acid	39-42	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
11774414-8	1998	(2) The mean value of anti-IL-8 IgG in GCF was greater than that of negative control +3 x s. CONCLUSION: A serine protease which can "cleave" IL-8 exists in GCF and GCF from AP sites contain auto-antibody against IL-8.	3-[3-[3-[(4~{s})-6-Azanyl-5-Cyano-3-Methyl-4-Propan-2-Yl-2~{h}-Pyrano[2,3-C]pyrazol-4-Yl]-5-(Trifluoromethyl)phenyl]phenyl]propanoic Acid	39-42	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
11774414-8	1998	(2) The mean value of anti-IL-8 IgG in GCF was greater than that of negative control +3 x s. CONCLUSION: A serine protease which can "cleave" IL-8 exists in GCF and GCF from AP sites contain auto-antibody against IL-8.	3-[3-[3-[(4~{s})-6-Azanyl-5-Cyano-3-Methyl-4-Propan-2-Yl-2~{h}-Pyrano[2,3-C]pyrazol-4-Yl]-5-(Trifluoromethyl)phenyl]phenyl]propanoic Acid	157-160	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
11774414-8	1998	(2) The mean value of anti-IL-8 IgG in GCF was greater than that of negative control +3 x s. CONCLUSION: A serine protease which can "cleave" IL-8 exists in GCF and GCF from AP sites contain auto-antibody against IL-8.	3-[3-[3-[(4~{s})-6-Azanyl-5-Cyano-3-Methyl-4-Propan-2-Yl-2~{h}-Pyrano[2,3-C]pyrazol-4-Yl]-5-(Trifluoromethyl)phenyl]phenyl]propanoic Acid	39-42	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
11774414-8	1998	(2) The mean value of anti-IL-8 IgG in GCF was greater than that of negative control +3 x s. CONCLUSION: A serine protease which can "cleave" IL-8 exists in GCF and GCF from AP sites contain auto-antibody against IL-8.	3-[3-[3-[(4~{s})-6-Azanyl-5-Cyano-3-Methyl-4-Propan-2-Yl-2~{h}-Pyrano[2,3-C]pyrazol-4-Yl]-5-(Trifluoromethyl)phenyl]phenyl]propanoic Acid	157-160	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
11774414-8	1998	(2) The mean value of anti-IL-8 IgG in GCF was greater than that of negative control +3 x s. CONCLUSION: A serine protease which can "cleave" IL-8 exists in GCF and GCF from AP sites contain auto-antibody against IL-8.	3-[3-[3-[(4~{s})-6-Azanyl-5-Cyano-3-Methyl-4-Propan-2-Yl-2~{h}-Pyrano[2,3-C]pyrazol-4-Yl]-5-(Trifluoromethyl)phenyl]phenyl]propanoic Acid	157-160	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
9531596-4	1998	We show that ATRA selectively inhibited LPS induction of TF expression in human monocytes and monocytic THP-1 cells without affecting LPS induction of tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8).	Tretinoin	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
9554339-11	1998	BCG induced IL-8 release was further enhanced in the presence of indomethacin.	Indomethacin	65-77	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
9547339-6	1998	15R/S-methyl-LXA4 and 16-phenoxy-LXA4 each attenuated (IC50 approximately 10 nM) IL-8 release.	15r	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
9547339-6	1998	15R/S-methyl-LXA4 and 16-phenoxy-LXA4 each attenuated (IC50 approximately 10 nM) IL-8 release.	s-methyl-lxa4	4-17	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
9547339-6	1998	15R/S-methyl-LXA4 and 16-phenoxy-LXA4 each attenuated (IC50 approximately 10 nM) IL-8 release.	16-phenoxy-lxa4	22-37	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
9564459-1	1998	The purpose of this study was to examine the association between experimental rhinovirus infection and the elaboration of interleukin-8 (IL-8) into nasal secretions of volunteers and to determine the effect of pentoxifylline on IL-8 elaboration and rhinovirus-associated common cold symptoms.	Pentoxifylline	210-224	C-X-C motif chemokine ligand 8	Homo sapiens	228-232
9558006-4	1998	Here, we present research examining paclitaxel"s ability to alter expression of the interleukin-1beta (IL-1beta) and IL-8 cytokines in primary human monocytes, T lymphocytes, and four human breast cancer cell lines: MCF-7, ZR-75-1, MDA-MB-468, and MDA-MB-231.	Paclitaxel	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
9566351-1	1998	The present studies demonstrate that histamine induces the secretion of IL-6, IL-8 and GM-CSF from human conjunctival epithelial cells in a dose- and time-dependent manner.	Histamine	37-46	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
9584909-3	1998	Triclosan is used in dentifrices in combination with either zinc citrate or sodium fluoride (NaF).	Triclosan	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
9584909-3	1998	Triclosan is used in dentifrices in combination with either zinc citrate or sodium fluoride (NaF).	Sodium Fluoride	76-91	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
9566351-3	1998	Emedastine potently inhibited histamine-induced IL-6, IL-8 and GM-CSF secretion with mean IC50 values of 2.23, 3.42 and 1.50 nM, respectively.	emedastine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
9628260-5	1998	RESULTS: Anthralin, at concentrations between 5 microM and 25 microM, caused a marked increase in granulocyte macrophage-colony stimulating factor (GM-CSF), interleukin (IL)-6, IL-8 and TNFalpha synthesis that was selectively inhibited by specific antioxidants.	Anthralin	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
9566351-3	1998	Emedastine potently inhibited histamine-induced IL-6, IL-8 and GM-CSF secretion with mean IC50 values of 2.23, 3.42 and 1.50 nM, respectively.	Histamine	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
9534964-5	1998	Furthermore, associated with this reduced expression of IL-8 receptors was impairment of both intracellular calcium flux and migration of PMNL in response to IL-8 in a group of HIV/TB patients compared with that in healthy persons.	Calcium	108-115	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
9641099-0	1998	Fluoride release from three different types of glass ionomer cements after exposure to NaF solution and APF gel.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
9641099-8	1998	As a result we conclude that glass ionomer cements can act as a rechargeable slow fluoride release systems and especially in caries active children, topical NaF applications with glass ionomer cements could be recommended as a preventive measure.	Fluorides	82-90	C-X-C motif chemokine ligand 8	Homo sapiens	157-160
9543141-6	1998	We then investigated the modulation of endometrial stromal cell IL-8 production and proliferation by antisense oligonucleotides specific for IL-8.	Oligonucleotides	111-127	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
9543141-8	1998	IL-8 antisense oligonucleotide treatment decreased IL-8 production by endometrial stromal cells in culture as well as cell proliferation when it is compared with scrambled (nonsense) oligonucleotide treatment (P &lt; 0.01).	Oligonucleotides	15-30	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9543141-8	1998	IL-8 antisense oligonucleotide treatment decreased IL-8 production by endometrial stromal cells in culture as well as cell proliferation when it is compared with scrambled (nonsense) oligonucleotide treatment (P &lt; 0.01).	Oligonucleotides	15-30	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
9543141-8	1998	IL-8 antisense oligonucleotide treatment decreased IL-8 production by endometrial stromal cells in culture as well as cell proliferation when it is compared with scrambled (nonsense) oligonucleotide treatment (P &lt; 0.01).	Oligonucleotides	183-198	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9543141-9	1998	Addition of IL-8 (1 ng/mL) reversed the proliferation inhibitory effect of IL-8 antisense oligonucleotides.	Oligonucleotides	90-106	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
9543141-9	1998	Addition of IL-8 (1 ng/mL) reversed the proliferation inhibitory effect of IL-8 antisense oligonucleotides.	Oligonucleotides	90-106	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
9551411-5	1998	The oral administration of indometacin farnesil (a prodrug that is converted to indomethacin after intestinal absorption) before the injection of IL-8 alleviated the infiltration of neutrophils.	indomethacin farnesil	27-47	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
9618706-6	1998	Moreover, histamine induces a significant increase of IL-6 and IL-8 secretion by EC.	Histamine	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
9627948-0	1998	Inhibition of interleukin-8 synthesis by intraarticular methotrexate therapy in patients with rheumatoid arthritis.	Methotrexate	56-68	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
9627948-4	1998	The intraarticular granulocyte counts and IL-8 levels decreased in all MTX treated patients on day 10-13 and stayed low in those patients who could be re-evaluated after 13 weeks.	Methotrexate	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
9516436-9	1998	However, the sequence of addition of poly(rU) to a diluted solution of ADP/NaF-treated enzyme had a profound effect on the extent of inhibition.	Poly U	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
9516436-9	1998	However, the sequence of addition of poly(rU) to a diluted solution of ADP/NaF-treated enzyme had a profound effect on the extent of inhibition.	Adenosine Diphosphate	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
9516436-10	1998	If the ADP/NaF-treated enzyme was diluted into an assay that lacked poly(rU) and the assay was subsequently initiated with poly(rU), the treated enzyme was not inhibited.	Adenosine Diphosphate	7-10	C-X-C motif chemokine ligand 8	Homo sapiens	11-14
9516436-10	1998	If the ADP/NaF-treated enzyme was diluted into an assay that lacked poly(rU) and the assay was subsequently initiated with poly(rU), the treated enzyme was not inhibited.	Poly U	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	11-14
9516436-10	1998	If the ADP/NaF-treated enzyme was diluted into an assay that lacked poly(rU) and the assay was subsequently initiated with poly(rU), the treated enzyme was not inhibited.	Poly U	123-131	C-X-C motif chemokine ligand 8	Homo sapiens	11-14
9516436-12	1998	ATP protected the enzyme from inhibition by ADP/NaF.	Adenosine Triphosphate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
9516436-12	1998	ATP protected the enzyme from inhibition by ADP/NaF.	Adenosine Diphosphate	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
9516436-13	1998	The stoichiometry between ADP and enzyme monomer in the inhibited enzyme complex was 2, as determined from titration of the ATPase activity ([ADP]/[E] = 2.2) and from the number of radiolabeled ADP bound to the inhibited enzyme ([ADP]/[E] = 1.7) in the presence of excess NaF, MgCl2, and poly(rU).	Adenosine Diphosphate	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	272-275
9516436-15	1998	The stoichiometry between (dU)18, a defined oligomeric nucleic acid substituting for poly(rU), and enzyme monomer in the inhibited enzyme complex was estimated to be 1 ([(dU)18/[E] = 1.2) from titration of the ATPase activity in the presence of excess ADP, MgCl2, and NaF.	Ruthenium	90-92	C-X-C motif chemokine ligand 8	Homo sapiens	268-271
9516436-15	1998	The stoichiometry between (dU)18, a defined oligomeric nucleic acid substituting for poly(rU), and enzyme monomer in the inhibited enzyme complex was estimated to be 1 ([(dU)18/[E] = 1.2) from titration of the ATPase activity in the presence of excess ADP, MgCl2, and NaF.	Adenosine Diphosphate	252-255	C-X-C motif chemokine ligand 8	Homo sapiens	268-271
9516436-15	1998	The stoichiometry between (dU)18, a defined oligomeric nucleic acid substituting for poly(rU), and enzyme monomer in the inhibited enzyme complex was estimated to be 1 ([(dU)18/[E] = 1.2) from titration of the ATPase activity in the presence of excess ADP, MgCl2, and NaF.	Magnesium Chloride	257-262	C-X-C motif chemokine ligand 8	Homo sapiens	268-271
9510190-3	1998	Full-length Tat (Tat101) enhanced IL-8 transcription through up-regulated transcription factor binding to the CD28-responsive element (CD28RE) in the IL-8 promoter.	cd28re	135-141	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
9510190-3	1998	Full-length Tat (Tat101) enhanced IL-8 transcription through up-regulated transcription factor binding to the CD28-responsive element (CD28RE) in the IL-8 promoter.	cd28re	135-141	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
9551411-7	1998	The TNF-alpha-stimulated expression of IL-8 mRNA and IL-8 production in the cultured synovial cells were markedly inhibited by dexamethasone.	Dexamethasone	127-140	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
9551411-7	1998	The TNF-alpha-stimulated expression of IL-8 mRNA and IL-8 production in the cultured synovial cells were markedly inhibited by dexamethasone.	Dexamethasone	127-140	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
9551411-8	1998	In conclusion, IL-8 levels were markedly elevated in the joint fluids of patients with DRA.	dra	87-90	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
9551411-9	1998	Interleukin-8 released from synovial cells may be an important factor to induce acute inflammation in DRA.	dra	102-105	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
9551411-10	1998	Dexamethasone and indomethacin may be effective for DRA by inhibiting the production and chemotactic actions of IL-8, respectively.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
9551411-10	1998	Dexamethasone and indomethacin may be effective for DRA by inhibiting the production and chemotactic actions of IL-8, respectively.	Indomethacin	18-30	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
9559913-6	1998	The PDE4 inhibitor rolipram had limited effect on zymosan-induced IL-8 generation.	Zymosan	50-57	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
9559913-0	1998	Effect of PDE4 inhibitors on zymosan-induced IL-8 release from human neutrophils: synergism with prostanoids and salbutamol.	Zymosan	29-36	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
9517588-8	1998	Furthermore, the serum IL-8 level showed a negative correlation with important indicators of impairment of lung function (DL(CO), TLC, VC) and PaO2.	pao2	143-147	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
9517606-9	1998	Budesonide decreased serum IL-8 from 9.2 +/- 3.7 to 6.2 +/- 2.1 pg/ml (p &lt; 0.001).	Budesonide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
9602633-7	1998	DEX caused dose dependent inhibition of IL-1 induced IL-8 (p &lt; 0.001) and MCP-1 (p &lt; 0.05) secretion and mRNA expression at all concentrations of rIL-1 beta.	Dexamethasone	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
9602633-10	1998	CONCLUSIONS: DEX is a potent inhibitor of OF IL-8 and MCP-1.	Dexamethasone	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
9559913-4	1998	In the present study, we examined the effects of cyclic AMP elevating agents on the ability of human neutrophils to generate IL-8 in response to zymosan particles.	Cyclic AMP	49-59	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
9559913-7	1998	In contrast, the PDE4 inhibitors RP 73401 and SB 207499 concentration-dependently suppressed IL-8 generation.	Cilomilast	46-55	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
9559913-4	1998	In the present study, we examined the effects of cyclic AMP elevating agents on the ability of human neutrophils to generate IL-8 in response to zymosan particles.	Zymosan	145-152	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
9559913-11	1998	The prostanoids prostaglandin E1 (PGE1) and PGE2 inhibited zymosan-induced IL-8 release from neutrophils in a dose-dependent manner, in response to 10(-5) M PGE1 and PGE2 inhibiting IL-8 generation by 89% and 75%, respectively.	Prostaglandins	4-15	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
9559913-11	1998	The prostanoids prostaglandin E1 (PGE1) and PGE2 inhibited zymosan-induced IL-8 release from neutrophils in a dose-dependent manner, in response to 10(-5) M PGE1 and PGE2 inhibiting IL-8 generation by 89% and 75%, respectively.	Prostaglandins	4-15	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
9559913-11	1998	The prostanoids prostaglandin E1 (PGE1) and PGE2 inhibited zymosan-induced IL-8 release from neutrophils in a dose-dependent manner, in response to 10(-5) M PGE1 and PGE2 inhibiting IL-8 generation by 89% and 75%, respectively.	Alprostadil	16-32	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
9559913-11	1998	The prostanoids prostaglandin E1 (PGE1) and PGE2 inhibited zymosan-induced IL-8 release from neutrophils in a dose-dependent manner, in response to 10(-5) M PGE1 and PGE2 inhibiting IL-8 generation by 89% and 75%, respectively.	Alprostadil	16-32	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
9559913-11	1998	The prostanoids prostaglandin E1 (PGE1) and PGE2 inhibited zymosan-induced IL-8 release from neutrophils in a dose-dependent manner, in response to 10(-5) M PGE1 and PGE2 inhibiting IL-8 generation by 89% and 75%, respectively.	Alprostadil	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
9559913-11	1998	The prostanoids prostaglandin E1 (PGE1) and PGE2 inhibited zymosan-induced IL-8 release from neutrophils in a dose-dependent manner, in response to 10(-5) M PGE1 and PGE2 inhibiting IL-8 generation by 89% and 75%, respectively.	Alprostadil	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
9559913-11	1998	The prostanoids prostaglandin E1 (PGE1) and PGE2 inhibited zymosan-induced IL-8 release from neutrophils in a dose-dependent manner, in response to 10(-5) M PGE1 and PGE2 inhibiting IL-8 generation by 89% and 75%, respectively.	Dinoprostone	44-48	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
9559913-11	1998	The prostanoids prostaglandin E1 (PGE1) and PGE2 inhibited zymosan-induced IL-8 release from neutrophils in a dose-dependent manner, in response to 10(-5) M PGE1 and PGE2 inhibiting IL-8 generation by 89% and 75%, respectively.	Dinoprostone	44-48	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
9559913-11	1998	The prostanoids prostaglandin E1 (PGE1) and PGE2 inhibited zymosan-induced IL-8 release from neutrophils in a dose-dependent manner, in response to 10(-5) M PGE1 and PGE2 inhibiting IL-8 generation by 89% and 75%, respectively.	Zymosan	59-66	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
9559913-11	1998	The prostanoids prostaglandin E1 (PGE1) and PGE2 inhibited zymosan-induced IL-8 release from neutrophils in a dose-dependent manner, in response to 10(-5) M PGE1 and PGE2 inhibiting IL-8 generation by 89% and 75%, respectively.	Zymosan	59-66	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
9559913-11	1998	The prostanoids prostaglandin E1 (PGE1) and PGE2 inhibited zymosan-induced IL-8 release from neutrophils in a dose-dependent manner, in response to 10(-5) M PGE1 and PGE2 inhibiting IL-8 generation by 89% and 75%, respectively.	Alprostadil	157-161	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
9559913-11	1998	The prostanoids prostaglandin E1 (PGE1) and PGE2 inhibited zymosan-induced IL-8 release from neutrophils in a dose-dependent manner, in response to 10(-5) M PGE1 and PGE2 inhibiting IL-8 generation by 89% and 75%, respectively.	Alprostadil	157-161	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
9559913-11	1998	The prostanoids prostaglandin E1 (PGE1) and PGE2 inhibited zymosan-induced IL-8 release from neutrophils in a dose-dependent manner, in response to 10(-5) M PGE1 and PGE2 inhibiting IL-8 generation by 89% and 75%, respectively.	Dinoprostone	166-170	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
9559913-12	1998	Similarly, the beta2-adrenoceptor agonist salbutamol also inhibited IL-8 generation, but it was less effective than the prostanoids.	Albuterol	42-52	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
9559913-14	1998	Significant synergism between prostanoids or salbutamol and the PDE4 inhibitors to inhibit IL-8 generation was observed.	Prostaglandins	30-41	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
9559913-14	1998	Significant synergism between prostanoids or salbutamol and the PDE4 inhibitors to inhibit IL-8 generation was observed.	Albuterol	45-55	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
9559913-18	1998	Pretreatment of neutrophils with these drugs completely reversed the inhibitory effects of a combination treatment with rolipram and PGE2 on zymosan-induced IL-8 release.	Rolipram	120-128	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
9559913-18	1998	Pretreatment of neutrophils with these drugs completely reversed the inhibitory effects of a combination treatment with rolipram and PGE2 on zymosan-induced IL-8 release.	Dinoprostone	133-137	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
9559913-18	1998	Pretreatment of neutrophils with these drugs completely reversed the inhibitory effects of a combination treatment with rolipram and PGE2 on zymosan-induced IL-8 release.	Zymosan	141-148	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
9559913-23	1998	Thus, our results demonstrate that cyclic AMP-elevating agents modulate the ability of neutrophils to generate IL-8 in response to a particulate stimulus.	Cyclic AMP	35-45	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
9613677-4	1998	This procedure revealed that T98G cells were the main source and that PA-treated monocytes effectively stimulated IL-8 and MCP-1 production by T98G cells.	paraform	70-72	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
9517777-4	1998	RESULTS: Nitric oxide production was partly (&lt; or = 50%) inhibited and IL-8 almost completely suppressed (&gt; 80%) by dexamethasone and methylprednisolone.	Dexamethasone	122-135	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
9525460-7	1998	The eosinophil-induced release of IL-8, GM-CSF, and sICAM-1 from the HNEC was significantly attenuated by treatment with fexofenadine.	fexofenadine	121-133	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
9617859-0	1998	Correlations between interleukin-8, and myeloperoxidase or luminol-dependent chemiluminescence in inflamed mucosa of ulcerative colitis.	Luminol	59-66	C-X-C motif chemokine ligand 8	Homo sapiens	21-34
9617859-1	1998	Interleukin-8 (IL-8) is a peptide which induces not only chemotaxis of neutrophils but also the release of reactive oxygen metabolites from the neutrophils.	Oxygen	116-122	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
9617859-1	1998	Interleukin-8 (IL-8) is a peptide which induces not only chemotaxis of neutrophils but also the release of reactive oxygen metabolites from the neutrophils.	Oxygen	116-122	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
9617859-6	1998	The levels of IL-8 were closely correlated to luminol-dependent chemiluminescence or myeloperoxidase levels.	Luminol	46-53	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
9498788-5	1998	The IL-8 produced under these conditions was biologically active as determined in the calcium mobilization assay.	Calcium	86-93	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
9517777-4	1998	RESULTS: Nitric oxide production was partly (&lt; or = 50%) inhibited and IL-8 almost completely suppressed (&gt; 80%) by dexamethasone and methylprednisolone.	Methylprednisolone	140-158	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
9517777-5	1998	Sulfasalazine in pharmacological concentration and indomethacin slightly increased IL-8.	Indomethacin	51-63	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
9517777-7	1998	CONCLUSION: Dexamethasone and methylprednisolone are inhibitors of human chondrocyte nitric oxide production, although to a lesser extent than for IL-8 production.	Methylprednisolone	30-48	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
9461540-4	1998	Cycloheximide (CHI, 10 microg/ml), an inhibitor of protein synthesis, maximally increased IL-8 mRNA levels 30-fold in H292 cells.	Cycloheximide	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
9520946-3	1998	In the present study, we further examined the effects of GHSA on TNF-alpha- and IL-1 beta-induced HRPE IL-8 and monocyte chemoattractant protein (MCP)-1 gene expression and protein secretion in HRPE.	ghsa	57-61	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
9520946-4	1998	At maximally effective concentrations, GHSA (2000 micrograms/ml) potentiated TNF-alpha (20 ng/ml)-stimulated HRPE IL-8 secretion approximately 7-fold.	ghsa	39-43	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
9520946-7	1998	Moreover, potentiation of HRPE IL-8 generation by GHSA appeared to be selective for TNF-alpha because, under similar conditions, GHSA was unable to enhance the IL-1 beta-stimulated IL-8 gene expression and protein secretion.	ghsa	50-54	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
9583368-0	1998	Glutamine-supplemented total parenteral nutrition reduces blood mononuclear cell interleukin-8 release in severe acute pancreatitis.	Glutamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
9583368-7	1998	Glutamine supplementation did not significantly influence TNF or IL-6 release, but, in contrast, median IL-8 release was reduced by day 7 in the glutamine group while it was increased in the conventional group (-17.7 ng/mL (median change over study period) versus +43.3 ng/mL, respectively; P=0.045).	Glutamine	145-154	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
9583368-8	1998	Small patient numbers and substantial interindividual variation limit the conclusions, but there is a trend for the glutamine group to have improved lymphocyte proliferation, and in the case of IL-8, reduced proinflammatory cytokine release.	Glutamine	116-125	C-X-C motif chemokine ligand 8	Homo sapiens	194-198
9692114-0	1998	N-acetylcysteine inhibits IL-1 alpha-induced IL-8 secretion by bronchial epithelial cells.	Acetylcysteine	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
10923535-5	1998	There was significant relationship between maternal serum and amniotic fluid IL8, TNF alpha with the time of the premature rupture of membanes.	membanes	134-142	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
9469462-7	1998	Moreover, RIA indicates that the activation of cellular p38 MAP kinase was required for the neutrophil IL-8 production stimulated by granulocyte-macrophage CSF or LPS as well as TNF-alpha, but not for that induced by PMA or ionomycin.	Ionomycin	224-233	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
9461540-4	1998	Cycloheximide (CHI, 10 microg/ml), an inhibitor of protein synthesis, maximally increased IL-8 mRNA levels 30-fold in H292 cells.	Cycloheximide	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
9480822-4	1998	Moreover, recombinant human [(Ala)-IL-8]77 induced apoptosis in leukemic cell lines such as K562, HL-60, KG-1, U937, THP-1 and Jurkat, but monocyte-derived IL-8 ([(Ser)-IL-8]72) did not.	Serine	164-167	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
9552221-10	1998	The total release of (IL-8) interleukin-8 and eicosanoids significantly decreased in patients treated with antibiotic or steroids and antibiotic.	Steroids	121-129	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
9452482-9	1998	Furthermore, the peptide aldehyde N-acetyl-Leu-Leu-norleucinal, an agent that blocks both IkappaBalpha proteolysis and NF-kappaB subunit translocation, abrogates recombinant human TNFalpha-inducible IL-8 gene transcription.	Aldehydes	25-33	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
9452482-9	1998	Furthermore, the peptide aldehyde N-acetyl-Leu-Leu-norleucinal, an agent that blocks both IkappaBalpha proteolysis and NF-kappaB subunit translocation, abrogates recombinant human TNFalpha-inducible IL-8 gene transcription.	acetylleucine	34-46	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
9452482-9	1998	Furthermore, the peptide aldehyde N-acetyl-Leu-Leu-norleucinal, an agent that blocks both IkappaBalpha proteolysis and NF-kappaB subunit translocation, abrogates recombinant human TNFalpha-inducible IL-8 gene transcription.	Leucine	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
9459261-5	1998	The peroxynitrite donor (SIN-1) caused an increase in both IL-8 accumulation (P = 0.0004) and elastase accumulation (P = 0.007).	Peroxynitrous Acid	4-17	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
9459261-9	1998	We investigated the effect of nitric oxide and peroxynitrite on interleukin-8 and elastase release by white cells during inflammation.	Peroxynitrous Acid	47-60	C-X-C motif chemokine ligand 8	Homo sapiens	64-90
9459261-10	1998	Nitric oxide and peroxynitrite had marked effects on elastase and interleukin-8, which suggests modulation of the inflammatory response.	Nitric Oxide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
9459261-10	1998	Nitric oxide and peroxynitrite had marked effects on elastase and interleukin-8, which suggests modulation of the inflammatory response.	Peroxynitrous Acid	17-30	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
9512898-3	1998	Interleukin 6 (IL-6) and IL-8 production in response to PMA were markedly diminished by the PKC inhibitor staurosporine.	Staurosporine	106-119	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
9473840-9	1998	Due to the inherent nonlinearities in the generation of the SA, the NAF is shown to achieve significantly better SA cancellation compared to the LAF.	sa	60-62	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
9616381-8	1998	Preincubation with cycloheximide inhibited IL-6 but not IL-8 transcription, and incubation of stimulated cells with actinomycin D stabilized IL-8 and also IL-6 mRNA.	Dactinomycin	116-129	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
9552221-10	1998	The total release of (IL-8) interleukin-8 and eicosanoids significantly decreased in patients treated with antibiotic or steroids and antibiotic.	Steroids	121-129	C-X-C motif chemokine ligand 8	Homo sapiens	28-41
9552221-12	1998	In conclusion, short-term treatment with enteric-coated amoxicillin-clavulanic acid decreases the intraluminal release of IL-8 and other inflammatory mediators.	Amoxicillin-Potassium Clavulanate Combination	56-83	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
9513367-3	1998	In patients without methylprednisolone treatment, IL-8 levels in BALF were 362 +/- 67 pg/ml on 0-POD and 948 +/- 359 pg/ml on 1-POD, and were approximately 10 times higher than those in plasma levels.	Methylprednisolone	20-38	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
9513367-6	1998	The patients with preoperative methylprednisolone treatment had significantly lower IL-8 levels in BALF and plasma compared with the patients without the treatment.	Methylprednisolone	31-49	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
9635030-0	1998	Taurine chloramine inhibits the production of superoxide anion, IL-6 and IL-8 in activated human polymorphonuclear leukocytes.	N-chlorotaurine	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
9537674-4	1998	RESULTS: There was a significant inhibition by dexamethasone (from 1 to 100 nM) on the secretion of monokines (IL-1beta, IL-6, IL-8 and TNF alpha) and lymphokines (IL-2, IL-4, IL-10 and IFN gamma), either after LPS or PHA stimulation (P &lt; 0.01).	Dexamethasone	47-60	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
10095866-0	1998	Effect of roxithromycin on IL-8 synthesis and proliferation of nasal polyp fibroblasts.	Roxithromycin	10-23	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
9583095-6	1998	We also found a negative correlation between the expression of IL-8 mRNA and creatinine clearance.	Creatinine	77-87	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
9598103-6	1998	The formation of dUTP from dCyd, was also enhanced by NaF, in parallel of dCK potentiation.	deoxyuridine triphosphate	17-21	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
9917534-7	1998	In conclusion, the reduction in TNF-alpha, IL-6 and IL-8 was most impressive with the polyacrylonitrile membrane after 4 h of hemofiltration and was largely due to adsorption.	polyacrylonitrile	86-103	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
9448049-6	1998	IL-8 release induced by TNF-alpha and IFN-gamma was partly inhibited by the Th-2-derived cytokines IL-4, IL-10, and IL-13, as well as by dexamethasone.	Dexamethasone	137-150	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9536224-0	1998	RANTES expression in psoriatic skin, and regulation of RANTES and IL-8 production in cultured epidermal keratinocytes by active vitamin D3 (tacalcitol).	Cholecalciferol	128-138	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
9536224-0	1998	RANTES expression in psoriatic skin, and regulation of RANTES and IL-8 production in cultured epidermal keratinocytes by active vitamin D3 (tacalcitol).	1 alpha,24-dihydroxyvitamin D3	140-150	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
9536224-13	1998	Tacalcitol (1 alpha,24(R)-dihydroxyvitamin D3), an active vitamin D3 analogue, inhibited RANTES and IL-8 production in cultured normal epidermal keratinocytes.	1 alpha,24-dihydroxyvitamin D3	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
9536224-13	1998	Tacalcitol (1 alpha,24(R)-dihydroxyvitamin D3), an active vitamin D3 analogue, inhibited RANTES and IL-8 production in cultured normal epidermal keratinocytes.	1 alpha,24-dihydroxyvitamin D3	12-45	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
9536224-13	1998	Tacalcitol (1 alpha,24(R)-dihydroxyvitamin D3), an active vitamin D3 analogue, inhibited RANTES and IL-8 production in cultured normal epidermal keratinocytes.	Cholecalciferol	35-45	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
9536226-0	1998	Calcipotriene-induced improvement in psoriasis is associated with reduced interleukin-8 and increased interleukin-10 levels within lesions.	calcipotriene	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
9536226-12	1998	Calcipotriene-induced clinical improvement of psoriasis is preceded by an increase in IL-10 and a concomitant decrease in IL-8 levels.	calcipotriene	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
14517454-7	1998	An angiogenic factor, interleukin 8, was dramatically induced in vascular endothelial cells treated with doxorubicin, but not in cells treated with cisplatin.	Doxorubicin	105-116	C-X-C motif chemokine ligand 8	Homo sapiens	22-35
14517454-8	1998	Co-administration of anti-interleukin 8 antibody almost completely blocked the doxorubicin-induced angiogenesis in vitro, suggesting a paracrine/autocrine control through drug-induced angiogenic factor(s).	Doxorubicin	79-90	C-X-C motif chemokine ligand 8	Homo sapiens	26-39
9917534-5	1998	The progressive decrease in cytokine concentrations was identical between the two filtration modes and most pronounced with the polyacrylonitrile membrane (reduction 77% for IL-6, 39% for TNF-alpha and 95% for IL-8 after 4 h of hemofiltration).	polyacrylonitrile	128-145	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
9473671-6	1998	Glutathione depletion also potentiated the inhibition by H2O2 of carbachol- or G-protein (NaF)-stimulated phosphoinositide hydrolysis, whereas phospholipase C activated by the calcium ionophore ionomycin was not inhibited.	Glutathione	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
9473671-6	1998	Glutathione depletion also potentiated the inhibition by H2O2 of carbachol- or G-protein (NaF)-stimulated phosphoinositide hydrolysis, whereas phospholipase C activated by the calcium ionophore ionomycin was not inhibited.	Phosphatidylinositols	106-122	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
9523735-2	1998	In addition to its cytotoxic effects on ovarian cancer cells, taxol can transcriptionally activate genes such as IL-8 that may play a role in tumorigenesis.	Paclitaxel	62-67	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
9473671-6	1998	Glutathione depletion also potentiated the inhibition by H2O2 of carbachol- or G-protein (NaF)-stimulated phosphoinositide hydrolysis, whereas phospholipase C activated by the calcium ionophore ionomycin was not inhibited.	Calcium	176-183	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
9473671-6	1998	Glutathione depletion also potentiated the inhibition by H2O2 of carbachol- or G-protein (NaF)-stimulated phosphoinositide hydrolysis, whereas phospholipase C activated by the calcium ionophore ionomycin was not inhibited.	Ionomycin	194-203	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
9473671-7	1998	The thiol-oxidizing agent diamide also inhibited phosphoinositide hydrolysis stimulated by carbachol or NaF, and glutathione depletion potentiated the diamide concentration-dependent inhibition.	Sulfhydryl Compounds	4-9	C-X-C motif chemokine ligand 8	Homo sapiens	104-107
9473671-7	1998	The thiol-oxidizing agent diamide also inhibited phosphoinositide hydrolysis stimulated by carbachol or NaF, and glutathione depletion potentiated the diamide concentration-dependent inhibition.	Diamide	26-33	C-X-C motif chemokine ligand 8	Homo sapiens	104-107
9473671-7	1998	The thiol-oxidizing agent diamide also inhibited phosphoinositide hydrolysis stimulated by carbachol or NaF, and glutathione depletion potentiated the diamide concentration-dependent inhibition.	Phosphatidylinositols	49-65	C-X-C motif chemokine ligand 8	Homo sapiens	104-107
9473671-6	1998	Glutathione depletion also potentiated the inhibition by H2O2 of carbachol- or G-protein (NaF)-stimulated phosphoinositide hydrolysis, whereas phospholipase C activated by the calcium ionophore ionomycin was not inhibited.	Hydrogen Peroxide	57-61	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
9588080-0	1998	[Production of IL-8 by the THP-1 monocyte cell line is regulated differently by cyclosporin and retinoic acid].	Cyclosporine	80-91	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
9588080-0	1998	[Production of IL-8 by the THP-1 monocyte cell line is regulated differently by cyclosporin and retinoic acid].	Tretinoin	96-109	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
9588080-7	1998	The aim of the experiment was to find out CsA effect and RA effect on production of IL-8 by THP-1 cell line.	Cyclosporine	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
9588080-7	1998	The aim of the experiment was to find out CsA effect and RA effect on production of IL-8 by THP-1 cell line.	Tretinoin	57-59	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
9588080-11	1998	It was found out that CsA inhibits IL-8 production by stimulated THP-1 monocyte cell line in dose dependence course.	Cyclosporine	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
9588080-12	1998	RA promotes IL-8 production by stimulated THP-1 monocyte cell line in dose dependence course.	Tretinoin	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
9523735-3	1998	Utilizing IL-8 as a prototypic marker of tumor-derived modulators of growth, we undertook a systematic study of taxol and 11 structurally modified taxol analogs to identify the region of the taxane skeleton responsible for IL-8 gene induction.	taxane	191-197	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
9523735-3	1998	Utilizing IL-8 as a prototypic marker of tumor-derived modulators of growth, we undertook a systematic study of taxol and 11 structurally modified taxol analogs to identify the region of the taxane skeleton responsible for IL-8 gene induction.	taxane	191-197	C-X-C motif chemokine ligand 8	Homo sapiens	223-227
9523735-5	1998	IL-8 gene induction was assessed by Northern blot analysis after 6 h and cytotoxicity after 72 h. RESULTS: Changes in the southern hemisphere (C-1 to C-4) of the taxane skeleton had greater effects on IL-8 induction than changes in the northern hemisphere (C-7 to C-11).	taxane	162-168	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9523735-5	1998	IL-8 gene induction was assessed by Northern blot analysis after 6 h and cytotoxicity after 72 h. RESULTS: Changes in the southern hemisphere (C-1 to C-4) of the taxane skeleton had greater effects on IL-8 induction than changes in the northern hemisphere (C-7 to C-11).	taxane	162-168	C-X-C motif chemokine ligand 8	Homo sapiens	201-205
9523735-6	1998	Some of the taxol analogs modified at positions C-1 and/or C-2 with increased hydrophobicity induced IL-8 expression more than threefold over that induced by taxol or taxotere and more than 20-fold over control cells.	Paclitaxel	12-17	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
9444409-6	1998	The level of IL-8 was significantly higher in the lavage fluid of patients with uterine endometritis than in the controls (p &lt; 0.001), and decreased by CAM treatment (p &lt; 0.01).	Clarithromycin	155-158	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
9523735-6	1998	Some of the taxol analogs modified at positions C-1 and/or C-2 with increased hydrophobicity induced IL-8 expression more than threefold over that induced by taxol or taxotere and more than 20-fold over control cells.	Paclitaxel	158-163	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
9523735-6	1998	Some of the taxol analogs modified at positions C-1 and/or C-2 with increased hydrophobicity induced IL-8 expression more than threefold over that induced by taxol or taxotere and more than 20-fold over control cells.	Docetaxel	167-175	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
9537772-11	1998	In contrast, hydrocortisone, but not cetirizine, reduced GM-CSF and IL-8 release.	Hydrocortisone	13-27	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
9701662-3	1998	Hydrolysis in low NaF concentrations results in the formation of discrete fluorapatite crystals on the surfaces of the CaHPO4 crystallites.	fluorapatite	74-86	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
9701662-3	1998	Hydrolysis in low NaF concentrations results in the formation of discrete fluorapatite crystals on the surfaces of the CaHPO4 crystallites.	calcium phosphate, dibasic, anhydrous	119-125	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
9701662-4	1998	At CaHPO4/NaF molar ratios from approximately 9:1 to 10:2, fluorapatite formed in approximately 3 h as the only crystalline product and complete hydrolysis of CaHPO4 occurred; a pH value as low as 2.4 was attained with solution species being predominantly sodium phosphate.	fluorapatite	59-71	C-X-C motif chemokine ligand 8	Homo sapiens	10-13
9701662-4	1998	At CaHPO4/NaF molar ratios from approximately 9:1 to 10:2, fluorapatite formed in approximately 3 h as the only crystalline product and complete hydrolysis of CaHPO4 occurred; a pH value as low as 2.4 was attained with solution species being predominantly sodium phosphate.	calcium phosphate, dibasic, anhydrous	159-165	C-X-C motif chemokine ligand 8	Homo sapiens	10-13
9701662-4	1998	At CaHPO4/NaF molar ratios from approximately 9:1 to 10:2, fluorapatite formed in approximately 3 h as the only crystalline product and complete hydrolysis of CaHPO4 occurred; a pH value as low as 2.4 was attained with solution species being predominantly sodium phosphate.	sodium phosphate	256-272	C-X-C motif chemokine ligand 8	Homo sapiens	10-13
9701662-5	1998	At NaF concentrations beyond those which result in pH minima, fluorapatite and CaF2 are the crystalline products.	fluorapatite	62-74	C-X-C motif chemokine ligand 8	Homo sapiens	3-6
9701662-6	1998	At 0.6 M NaF, pseudomorphs composed of fluorapatite and CaF2 crystals form without developing morphologies characteristic of individual fluorapatite and CaF2 crystals.	fluorapatite	39-51	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
9701662-7	1998	CaHPO2 can hydrolyze completely to fluorapatite and CaF2 within a few hours depending on NaF concentration and liquid-to-solids ratio.	cahpo2	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	89-92
9701662-7	1998	CaHPO2 can hydrolyze completely to fluorapatite and CaF2 within a few hours depending on NaF concentration and liquid-to-solids ratio.	fluorapatite	35-47	C-X-C motif chemokine ligand 8	Homo sapiens	89-92
9434794-6	1998	After exposure of human monocytes to HOCl-LDL, it was found that mRNA and protein of the chemokine IL-8 was strongly induced, while the chemokine MCP-1 was not.	Hypochlorous Acid	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
9472473-6	1998	RESULTS: GHSA at 500 micrograms/ml concentration induced a significant increase in keratocyte IL-8 and MCP-1 protein secretion over the 24 h time course.	ghsa	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
9472473-9	1998	The levels of GHSA (500 micrograms/ml)-induced keratocyte IL-8 and MCP-1 expression were similar to that induced by IL-1 beta (0.02 ng/ml) and TNF-alpha (2.0 ng/ml).	ghsa	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
9419178-0	1998	Effects of nitric oxide on chemotaxis and endotoxin-induced interleukin-8 production in human neutrophils.	Nitric Oxide	11-23	C-X-C motif chemokine ligand 8	Homo sapiens	60-73
9543278-9	1998	Treatment of DPB with macrolides for 6 months significantly reduced neutrophil count and concentrations of defensins and IL-8 in BALF.	Macrolides	22-32	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
9506829-0	1998	Stimulation of interleukin-8 production by acidic polysaccharides from the root of Panax ginseng.	Polysaccharides	50-65	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
9506829-5	1998	We found that one component, ginsenan S-IIA, is a potent inducer of IL-8 production by human monocytes and THP-1 cells, and this induction is accompanied by increased IL-8 mRNA expression.	ginsenan	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
9506829-5	1998	We found that one component, ginsenan S-IIA, is a potent inducer of IL-8 production by human monocytes and THP-1 cells, and this induction is accompanied by increased IL-8 mRNA expression.	ginsenan	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
9552003-7	1998	In contrast, while IL-8 production in response to S. cerevisiae and zymosan was enhanced in the presence of TNF-alpha, no MIP-1alpha was produced.	Zymosan	68-75	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
9485196-2	1998	It shares CXCR2 with all neutrophil-activating chemokines, which like IL-8 have a conserved Glu-Leu-Arg (ELR) N-terminal motif, but is generally considered to be the only relevant agonist for CXCR1.	Glutamic Acid	92-95	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
9485196-2	1998	It shares CXCR2 with all neutrophil-activating chemokines, which like IL-8 have a conserved Glu-Leu-Arg (ELR) N-terminal motif, but is generally considered to be the only relevant agonist for CXCR1.	Leucine	96-99	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
9485196-2	1998	It shares CXCR2 with all neutrophil-activating chemokines, which like IL-8 have a conserved Glu-Leu-Arg (ELR) N-terminal motif, but is generally considered to be the only relevant agonist for CXCR1.	Arginine	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
9485196-3	1998	IL-8 has a basic residue at the sixth position after the second cysteine, which was suggested to contribute to CXCR1 specificity.	Cysteine	64-72	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9449504-4	1998	Dexamethasone (DEX) inhibited both generation and secretion of IL-8 in a dose-dependent fashion.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
9449504-4	1998	Dexamethasone (DEX) inhibited both generation and secretion of IL-8 in a dose-dependent fashion.	Dexamethasone	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
9449504-5	1998	DEX also dampened formyl-methionyl-leucyl-phenylalanine-or ionomycin-induced eosinophil IL-8 production.	Dexamethasone	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
9449504-5	1998	DEX also dampened formyl-methionyl-leucyl-phenylalanine-or ionomycin-induced eosinophil IL-8 production.	Ionomycin	59-68	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
9419178-4	1998	However, lipopolysaccharide-induced IL-8 production was increased in a dose-dependent manner by a combination of sodium nitroprusside and N-acetylcysteine (P = .03) or by S-nitrosoglutathione (P = .004).	Nitroprusside	113-133	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
9419178-4	1998	However, lipopolysaccharide-induced IL-8 production was increased in a dose-dependent manner by a combination of sodium nitroprusside and N-acetylcysteine (P = .03) or by S-nitrosoglutathione (P = .004).	Acetylcysteine	138-154	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
9419178-4	1998	However, lipopolysaccharide-induced IL-8 production was increased in a dose-dependent manner by a combination of sodium nitroprusside and N-acetylcysteine (P = .03) or by S-nitrosoglutathione (P = .004).	S-Nitrosoglutathione	171-191	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
9749826-2	1998	A time-dependent and significant production of IL-8 was detected in the extracellular fluid of astrocyte-rich cultured cells at 2, 3 and 6 hrs after treatment with acidified Krebs-HEPES buffer (pH 6.9), although such production did not appear in the fluid of neuron-rich cells.	krebs	174-179	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
9419178-7	1998	These data suggest that NO does not directly affect neutrophil chemotaxis but may indirectly alter chemotactic responses by increasing IL-8 production via a cGMP-independent pathway.	Cyclic GMP	157-161	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
9419203-0	1998	Cryptococcal glucuronoxylomannan induces interleukin (IL)-8 production by human microglia but inhibits neutrophil migration toward IL-8.	cryptococcal glucuronoxylomannan	0-32	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
9419203-3	1998	When added directly to the PMNL, GXM (both serotypes) potently blocked PMNL migration toward IL-8.	glucuronoxylomannan	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
9419203-5	1998	These findings suggest that GXM can induce IL-8 production in the brain but that GXM in the systemic circulation inhibits migration of PMNL toward IL-8.	glucuronoxylomannan	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
10224600-7	1998	RESULTS: Both forms of PGPS and LPS stimulated IL-6 and IL-8 production by human fetal membranes.	pgps	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
10224600-8	1998	Of note is that LPS stimulated IL-6 to a greater degree than IL-8, while PGPS stimulated IL-8 to a greater degree than IL-6.	pgps	73-77	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
9597508-0	1998	[Inhibition of neutrophil-derived IL-8 production caused by EM (erythromycin) 201 derivative: modification of the activities by the 5-position desosamine side chain].	Erythromycin	60-62	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
9597508-0	1998	[Inhibition of neutrophil-derived IL-8 production caused by EM (erythromycin) 201 derivative: modification of the activities by the 5-position desosamine side chain].	Erythromycin	64-76	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
9597508-0	1998	[Inhibition of neutrophil-derived IL-8 production caused by EM (erythromycin) 201 derivative: modification of the activities by the 5-position desosamine side chain].	desosamine	143-153	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
9749826-2	1998	A time-dependent and significant production of IL-8 was detected in the extracellular fluid of astrocyte-rich cultured cells at 2, 3 and 6 hrs after treatment with acidified Krebs-HEPES buffer (pH 6.9), although such production did not appear in the fluid of neuron-rich cells.	HEPES	180-185	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
9749826-5	1998	The increase of IL-8 in astrocyte-rich cultures induced by acidosis was potentiated by treatment with glutamate, which enhanced the increase of cytosolic Ca2+ levels under acidosis, and was affected by extracellular Ca2+ conditions, by cyclosporine A, an inhibitor of calcineurin, and by trifluoperazine, an inhibitor of phospholipase A2.	Glutamic Acid	102-111	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
9749826-5	1998	The increase of IL-8 in astrocyte-rich cultures induced by acidosis was potentiated by treatment with glutamate, which enhanced the increase of cytosolic Ca2+ levels under acidosis, and was affected by extracellular Ca2+ conditions, by cyclosporine A, an inhibitor of calcineurin, and by trifluoperazine, an inhibitor of phospholipase A2.	Cyclosporine	236-250	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
9749826-5	1998	The increase of IL-8 in astrocyte-rich cultures induced by acidosis was potentiated by treatment with glutamate, which enhanced the increase of cytosolic Ca2+ levels under acidosis, and was affected by extracellular Ca2+ conditions, by cyclosporine A, an inhibitor of calcineurin, and by trifluoperazine, an inhibitor of phospholipase A2.	Trifluoperazine	288-303	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
9749826-6	1998	Significant inhibition of IL-8 production was detected after 6 hrs of pretreatment with trifluoperazine.	Trifluoperazine	88-103	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
9432117-0	1998	Butyrate enhances interleukin (IL)-8 secretion by intestinal epithelial cells in response to IL-1beta and lipopolysaccharide.	Butyrates	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	18-36
9432117-4	1998	We hypothesized that butyrate may alter the secretion of IL-8 by intestinal epithelial cells in response to stimulation by IL-1beta or lipopolysaccharide.	Butyrates	21-29	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
9432117-8	1998	Lipopolysaccharide induced the secretion of IL-8 only after Caco-2 cells cells had been cultured with sodium butyrate.	Butyric Acid	102-117	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
9432117-9	1998	Furthermore, butyrate significantly enhanced IL-8 secretion by cells stimulated with IL-1beta.	Butyrates	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
9460084-7	1998	Addition of CSAIDs to OA-affected cartilage differentially regulates IL-6 and IL-8 production by inhibiting the spontaneous release of IL-6 but not IL-8 in ex vivo conditions.	csaids	12-18	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
9432117-10	1998	Butyrate also increased IL-8 mRNA accumulation in stimulated Caco-2 cells.	Butyrates	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
9460084-7	1998	Addition of CSAIDs to OA-affected cartilage differentially regulates IL-6 and IL-8 production by inhibiting the spontaneous release of IL-6 but not IL-8 in ex vivo conditions.	csaids	12-18	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
10660968-3	1998	This study investigates the IL-8 behaviour in stable angina pectoris after myocardial ischaemia induced by dipyridamole (14 patients) and in unstable angina pectoris, Braunwald"s class III (35 patients).	Dipyridamole	107-119	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
10216370-8	1998	The level of IL-8 in urine (uIL-8) was elevated in patients with acute graft rejection and uIL-8 decreased after antirejection treatment (772 +/- 241 pg/mg cr.	Chromium	99-101	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
10216370-16	1998	Patients with higher concentrations of serum creatinine during UTI had high urine levels of IL-8.	Creatinine	45-55	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
9646397-2	1998	After two minutes use in vivo, the release of fluoride from the pointed section of a toothpick impregnated in 4% NaF was estimated to 0.15 mg. Toothpicks produced similar or somewhat higher fluoride concentrations in the approximal area compared with other fluoride-containing products, like dentifrice, mouthrinse solution and tablet.	Fluorides	46-54	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
9646397-3	1998	The mean fluoride concentration in an approximal area treated for two minutes with a toothpick impregnated in 4% NaF was around 11 mM/l.	Fluorides	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
9373254-10	1997	MC-sup and HMC-1-sup induced chemotaxis in blood monocytes (Mo) (control: 100% +/- 12% v 2-hour-MC-sup: 463% +/- 38% v HMC-1-sup: 532% +/- 12%), and a monoclonal antibody (MoAb) to MCP-1 (but not MoAb to IL-8) inhibited Mo-chemotaxis induced by MC-sup or HMC-1-sup (39% to 55% inhibition, P &lt; .05).	mc-sup	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
9407069-2	1997	In this study, we demonstrate that oxidant stress induced by tumor necrosis factor alpha (TNFalpha) or H2O2 differentially regulates intercellular adhesion molecule-1 (ICAM-1) and interleukin-8 (IL-8) gene expression in endothelial and epithelial cells.	Hydrogen Peroxide	103-107	C-X-C motif chemokine ligand 8	Homo sapiens	180-193
9407069-2	1997	In this study, we demonstrate that oxidant stress induced by tumor necrosis factor alpha (TNFalpha) or H2O2 differentially regulates intercellular adhesion molecule-1 (ICAM-1) and interleukin-8 (IL-8) gene expression in endothelial and epithelial cells.	Hydrogen Peroxide	103-107	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
9407069-4	1997	In contrast, H2O2 selectively induced only ICAM-1 in HMEC-1 and only IL-8 in A549.	Hydrogen Peroxide	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
9407069-8	1997	The increased neutrophil motility stimulated by conditioned media from H2O2- or TNFalpha-exposed A549 cells was completely inhibited by an anti-IL-8 antibody.	Hydrogen Peroxide	71-75	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
9408252-7	1997	Production of both IL-6 and IL-8 was stimulated in a concentration-dependent fashion by interleukin-1beta (0.1-10 ng/ml), tumor necrosis factor-alpha (1-100 ng/ml), and bacterial lipopolysaccharide (0.1-10 microg/ml), and also by 100 nM phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	237-268	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
9459309-9	1997	We found that among various sphingosine derivatives, Sph-1-P specifically inhibited the IL-8- or fLMP-induced chemotactic migration of neutrophils at concentrations below 1 microM.	Sphingosine	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
9398246-1	1997	CXCR2 is a seven-transmembrane receptor that transduces intracellular signals in response to the chemokines IL-8, MGSA/GRO, and other ELR motif-containing CXC chemokines by coupling to heterotrimeric GTP-binding proteins.	Guanosine Triphosphate	200-203	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
9373254-10	1997	MC-sup and HMC-1-sup induced chemotaxis in blood monocytes (Mo) (control: 100% +/- 12% v 2-hour-MC-sup: 463% +/- 38% v HMC-1-sup: 532% +/- 12%), and a monoclonal antibody (MoAb) to MCP-1 (but not MoAb to IL-8) inhibited Mo-chemotaxis induced by MC-sup or HMC-1-sup (39% to 55% inhibition, P &lt; .05).	hmc-1-sup	11-20	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
9366309-6	1997	RESULTS: After 2 weeks to 1 month of oral L-arginine treatment, urinary levels of nitric oxide synthase related enzymes and products increased significantly, while levels of the cytokine IL-8 were not changed significantly.	Arginine	42-52	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
21160545-4	1997	We observed that the principal benzene metabolites, represented by hydroquinone, 1,4-benzoquinone, phenol, 1,2,4-benzenetriol, and catechol, significantly alters the production of transforming growth factor of (TGF)-alpha and interleukin (IL)-8 in human epidermal keratinocyte cultures.	Benzene	31-38	C-X-C motif chemokine ligand 8	Homo sapiens	226-244
21160545-4	1997	We observed that the principal benzene metabolites, represented by hydroquinone, 1,4-benzoquinone, phenol, 1,2,4-benzenetriol, and catechol, significantly alters the production of transforming growth factor of (TGF)-alpha and interleukin (IL)-8 in human epidermal keratinocyte cultures.	hydroquinone	67-79	C-X-C motif chemokine ligand 8	Homo sapiens	226-244
9400825-1	1997	Priming of polymorphonuclear neutrophils (PMN) in whole blood (by tumor necrosis factor alpha and interleukin-8 for enhancement of luminol-dependent chemiluminescence induced by human complement-opsonized zymosan) was stable for 120 min.	Luminol	131-138	C-X-C motif chemokine ligand 8	Homo sapiens	98-111
9404762-10	1997	Treatment of DPB patients with macrolides significantly reduced the serum levels of these soluble adhesion molecules and BALF concentrations of IL-1 beta and IL-8.	Macrolides	31-41	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
9412820-7	1997	In addition, both PGE1 and SM-6 increased production of TGF-beta 1, IL-8 and IL-6 and levels of cAMP in both cell types.	Alprostadil	18-22	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
9412820-7	1997	In addition, both PGE1 and SM-6 increased production of TGF-beta 1, IL-8 and IL-6 and levels of cAMP in both cell types.	SM 10906	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
21160545-7	1997	Binary combinations of selected benzene metabolites synergized in the induction of IL-8, while benzene, by itself, induced about a three-fold increase in IL-8 production.	Benzene	32-39	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
21160545-7	1997	Binary combinations of selected benzene metabolites synergized in the induction of IL-8, while benzene, by itself, induced about a three-fold increase in IL-8 production.	Benzene	95-102	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
9400833-3	1997	Their use allowed us to observe that Cbl was tyrosine phosphorylated in response to some (FcgammaRII ligation, opsonized bacteria and zymosan, granulocyte-macrophage colony-stimulating factor, monosodium urate, and calcium pyrophosphate microcrystals), but not all (fMet-Leu-Phe, interleukin-8) neutrophil agonists.	Tyrosine	45-53	C-X-C motif chemokine ligand 8	Homo sapiens	280-293
9396683-0	1997	Inhibitory effect of macrolides on interleukin-8 secretion from cultured human nasal epithelial cells.	Macrolides	21-31	C-X-C motif chemokine ligand 8	Homo sapiens	35-48
9396683-2	1997	The authors studied the effect of macrolides on interleukin (IL)-8 secretion from cultured human nasal epithelial cells.	Macrolides	34-44	C-X-C motif chemokine ligand 8	Homo sapiens	48-66
9396683-7	1997	These results indicate that macrolide antibiotics may act as an immunomodulator to reduce IL-8 in inflammatory sites and, at least partially, account for the clinically discrepant effects between 14- and 16-membered ring macrolides in long-term low-dose therapy for chronic sinusitis.	Macrolides	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
9462189-5	1997	TNF alpha, IL-6, and IL-8 concentrations were significantly related to gestational age and duration of supplemental oxygen; TNF alpha, IL-6, and IL-8 concentrations also correlated with length of time on the ventilator.	Oxygen	116-122	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
9368010-3	1997	Using methyl-beta-N-acetylglucosaminide as a substrate, the optimal activity was obtained with 0.1% Triton X-100, 30 mM NaF, 20 mM Mn2+, 5 mM AMP in a 30 mM MOPS (3-(N-morpholino) propanesulfonic acid) buffer at pH 6.7.	methyl-beta-n-acetylglucosaminide	6-39	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
9368010-3	1997	Using methyl-beta-N-acetylglucosaminide as a substrate, the optimal activity was obtained with 0.1% Triton X-100, 30 mM NaF, 20 mM Mn2+, 5 mM AMP in a 30 mM MOPS (3-(N-morpholino) propanesulfonic acid) buffer at pH 6.7.	Octoxynol	100-112	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
9368010-3	1997	Using methyl-beta-N-acetylglucosaminide as a substrate, the optimal activity was obtained with 0.1% Triton X-100, 30 mM NaF, 20 mM Mn2+, 5 mM AMP in a 30 mM MOPS (3-(N-morpholino) propanesulfonic acid) buffer at pH 6.7.	Manganese(2+)	131-135	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
9368010-3	1997	Using methyl-beta-N-acetylglucosaminide as a substrate, the optimal activity was obtained with 0.1% Triton X-100, 30 mM NaF, 20 mM Mn2+, 5 mM AMP in a 30 mM MOPS (3-(N-morpholino) propanesulfonic acid) buffer at pH 6.7.	Adenosine Monophosphate	142-145	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
9368010-3	1997	Using methyl-beta-N-acetylglucosaminide as a substrate, the optimal activity was obtained with 0.1% Triton X-100, 30 mM NaF, 20 mM Mn2+, 5 mM AMP in a 30 mM MOPS (3-(N-morpholino) propanesulfonic acid) buffer at pH 6.7.	morpholinopropane sulfonic acid	157-161	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
9368010-3	1997	Using methyl-beta-N-acetylglucosaminide as a substrate, the optimal activity was obtained with 0.1% Triton X-100, 30 mM NaF, 20 mM Mn2+, 5 mM AMP in a 30 mM MOPS (3-(N-morpholino) propanesulfonic acid) buffer at pH 6.7.	morpholinopropane sulfonic acid	163-200	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
9366432-0	1997	Hamycin inhibits IL-8-induced biologic response by modulating its receptor in human polymorphonuclear neutrophils.	hamycin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
9366432-2	1997	We have found that hamycin, an antifungal agent, reduces IL-8-induced migration and binding of 125I-labeled IL-8 to neutrophils by 66 and 75%, respectively.	hamycin	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
9366432-2	1997	We have found that hamycin, an antifungal agent, reduces IL-8-induced migration and binding of 125I-labeled IL-8 to neutrophils by 66 and 75%, respectively.	hamycin	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
9366432-3	1997	Other IL-8-induced biologic functions, such as superoxide generation, intracellular Ca2+ mobilization, and enzyme release were also reduced in hamycin-treated cells by 50 to 75%.	Superoxides	47-57	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
9366432-3	1997	Other IL-8-induced biologic functions, such as superoxide generation, intracellular Ca2+ mobilization, and enzyme release were also reduced in hamycin-treated cells by 50 to 75%.	hamycin	143-150	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
9366432-6	1997	Chemical cross-linking of 125I-labeled IL-8 to its receptor followed by 10% SDS-PAGE analysis and autoradiography showed that the signals in hamycin-treated cells were considerably reduced compared with those in controls.	Iodine-125	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
9366432-6	1997	Chemical cross-linking of 125I-labeled IL-8 to its receptor followed by 10% SDS-PAGE analysis and autoradiography showed that the signals in hamycin-treated cells were considerably reduced compared with those in controls.	hamycin	141-148	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
9353345-9	1997	The tyrosine kinase inhibitor, genistein, blocked tyrosine phosphorylation and secretion of interleukin-8, whereas the MAP kinase kinase inhibitor PD98059 partially inhibited secretion of interleukin-8.	Tyrosine	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	92-105
9353345-9	1997	The tyrosine kinase inhibitor, genistein, blocked tyrosine phosphorylation and secretion of interleukin-8, whereas the MAP kinase kinase inhibitor PD98059 partially inhibited secretion of interleukin-8.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	147-154	C-X-C motif chemokine ligand 8	Homo sapiens	188-201
9354625-9	1997	The endothelial cell binding sites for IL-8, RANTES, and MCP-1 were deduced to be glycosaminoglycans since competition assays showed the biphasic curves and micromolar IC50 values seen in studies with immobilized heparin, and mRNA for known chemokine receptors was not detected.	Glycosaminoglycans	82-100	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
9354625-9	1997	The endothelial cell binding sites for IL-8, RANTES, and MCP-1 were deduced to be glycosaminoglycans since competition assays showed the biphasic curves and micromolar IC50 values seen in studies with immobilized heparin, and mRNA for known chemokine receptors was not detected.	Heparin	213-220	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
9354625-12	1997	Removal of glycosaminoglycans from CHO cells expressing chemokine receptors CXCR1, CCR1, or CCR2 resulted in 40-70% decreases in the binding of RANTES, MCP-1, IL-8, and MIP-1alpha.	Glycosaminoglycans	11-29	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
9431991-0	1997	1alpha,25-dihydroxyvitamin D3 and a variety of its natural metabolites transcriptionally repress nuclear-factor-kappaB-mediated interleukin-8 gene expression.	Calcitriol	0-29	C-X-C motif chemokine ligand 8	Homo sapiens	128-141
9431991-3	1997	1alpha,25-Dihydroxyvitamin D3 (calcitriol) repressed IL-8 promoter activity induced by tumor necrosis factor-alpha (TNF-alpha) by 50%, compared to 30% inhibition using dexamethasone, an effect consistent with its effect on TNF-alpha-induced IL-8 release and IL-8 mRNA levels.	Calcitriol	0-29	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
9431991-3	1997	1alpha,25-Dihydroxyvitamin D3 (calcitriol) repressed IL-8 promoter activity induced by tumor necrosis factor-alpha (TNF-alpha) by 50%, compared to 30% inhibition using dexamethasone, an effect consistent with its effect on TNF-alpha-induced IL-8 release and IL-8 mRNA levels.	Calcitriol	0-29	C-X-C motif chemokine ligand 8	Homo sapiens	241-245
9431991-3	1997	1alpha,25-Dihydroxyvitamin D3 (calcitriol) repressed IL-8 promoter activity induced by tumor necrosis factor-alpha (TNF-alpha) by 50%, compared to 30% inhibition using dexamethasone, an effect consistent with its effect on TNF-alpha-induced IL-8 release and IL-8 mRNA levels.	Calcitriol	0-29	C-X-C motif chemokine ligand 8	Homo sapiens	241-245
9431991-3	1997	1alpha,25-Dihydroxyvitamin D3 (calcitriol) repressed IL-8 promoter activity induced by tumor necrosis factor-alpha (TNF-alpha) by 50%, compared to 30% inhibition using dexamethasone, an effect consistent with its effect on TNF-alpha-induced IL-8 release and IL-8 mRNA levels.	Calcitriol	31-41	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
9431991-3	1997	1alpha,25-Dihydroxyvitamin D3 (calcitriol) repressed IL-8 promoter activity induced by tumor necrosis factor-alpha (TNF-alpha) by 50%, compared to 30% inhibition using dexamethasone, an effect consistent with its effect on TNF-alpha-induced IL-8 release and IL-8 mRNA levels.	Calcitriol	31-41	C-X-C motif chemokine ligand 8	Homo sapiens	241-245
9431991-3	1997	1alpha,25-Dihydroxyvitamin D3 (calcitriol) repressed IL-8 promoter activity induced by tumor necrosis factor-alpha (TNF-alpha) by 50%, compared to 30% inhibition using dexamethasone, an effect consistent with its effect on TNF-alpha-induced IL-8 release and IL-8 mRNA levels.	Calcitriol	31-41	C-X-C motif chemokine ligand 8	Homo sapiens	241-245
9431991-4	1997	A variety of vitamin D metabolites caused the same repressive effect on IL-8 promoter activation as calcitriol.	Vitamin D	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
9431991-5	1997	However, only those metabolites which were able to transactivate a classical vitamin D response element had the ability to repress IL-8 promoter activation, suggesting that this repression is mediated via vitamin D receptor (VDR).	Vitamin D	77-86	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
9431991-6	1997	Furthermore, overexpression of VDR in the parental G-361 cell line enhanced the repressive effect of calcitriol on activation of the IL-8 promoter by either TNF-alpha stimulation or overexpression of the NF-kappaB subunit p65.	Calcitriol	101-111	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
9431991-7	1997	Electrophoretic mobility shift assays using nuclear extracts from A3 cells showed that calcitriol decreased the abundance of nuclear factors bound to the NF-kappaB binding site of the IL-8 promoter and this reduced binding of NF-kappaB proteins presumably contributes to its inhibitory action.	Calcitriol	87-97	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
9353345-9	1997	The tyrosine kinase inhibitor, genistein, blocked tyrosine phosphorylation and secretion of interleukin-8, whereas the MAP kinase kinase inhibitor PD98059 partially inhibited secretion of interleukin-8.	Genistein	31-40	C-X-C motif chemokine ligand 8	Homo sapiens	92-105
9372795-2	1997	Also, it has not been established that incorporation of trimetaphosphate (TMP) improves the anticaries activity of NaF toothpastes.	trimetaphosphoric acid	56-72	C-X-C motif chemokine ligand 8	Homo sapiens	115-118
9353042-6	1997	Treatment of PNG with the leukotriene-B4 inhibitor MK-886 prior to stimulation with M. tuberculosis or LAM partially blocked IL-8 and GRO-alpha induction, suggesting involvement of the 5-lipoxygenase pathway in the secretion of these chemokines.	Leukotrienes	26-37	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
9353042-6	1997	Treatment of PNG with the leukotriene-B4 inhibitor MK-886 prior to stimulation with M. tuberculosis or LAM partially blocked IL-8 and GRO-alpha induction, suggesting involvement of the 5-lipoxygenase pathway in the secretion of these chemokines.	MK-886	51-57	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
9372795-2	1997	Also, it has not been established that incorporation of trimetaphosphate (TMP) improves the anticaries activity of NaF toothpastes.	trimetaphosphoric acid	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	115-118
9372795-13	1997	The mean three-year clinical-only DMFS increment for the subjects using 1500-ppm-NaF pastes was 3.93, which was 6% lower than the corresponding mean of 4.19 for the 1000-ppm-NaF pastes.	dmfs	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
9357758-2	1997	We characterized the mechanisms by which hyaluronic acid (HA) regulates interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-8 (IL-8) production in human uterine fibroblasts.	Hyaluronic Acid	41-56	C-X-C motif chemokine ligand 8	Homo sapiens	147-160
9353419-8	1997	Specificity of action is suggested as IL-1-stimulated interleukin-8 (IL-8) production, which is known to be an NFkappaB-regulated event, was also inhibited by hymenialdisine, whereas IL-1-induced production of vascular endothelial growth factor, a non-NFkappaB-regulated gene, was not affected by exposure to hymenialdisine.	hymenialdisine	159-173	C-X-C motif chemokine ligand 8	Homo sapiens	38-67
9353419-8	1997	Specificity of action is suggested as IL-1-stimulated interleukin-8 (IL-8) production, which is known to be an NFkappaB-regulated event, was also inhibited by hymenialdisine, whereas IL-1-induced production of vascular endothelial growth factor, a non-NFkappaB-regulated gene, was not affected by exposure to hymenialdisine.	hymenialdisine	159-173	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
9353419-8	1997	Specificity of action is suggested as IL-1-stimulated interleukin-8 (IL-8) production, which is known to be an NFkappaB-regulated event, was also inhibited by hymenialdisine, whereas IL-1-induced production of vascular endothelial growth factor, a non-NFkappaB-regulated gene, was not affected by exposure to hymenialdisine.	hymenialdisine	309-323	C-X-C motif chemokine ligand 8	Homo sapiens	38-67
9353419-8	1997	Specificity of action is suggested as IL-1-stimulated interleukin-8 (IL-8) production, which is known to be an NFkappaB-regulated event, was also inhibited by hymenialdisine, whereas IL-1-induced production of vascular endothelial growth factor, a non-NFkappaB-regulated gene, was not affected by exposure to hymenialdisine.	hymenialdisine	309-323	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
11189316-4	1997	In biological activity test of IL-8 inhibitor, using pooled GCF taken from 8 AP patients (23 teeth), the results showed that the GCF (without recombinant human IL-8, rhIL-8) caused more white blood cell (WBC) migration than blank control group (physiological saline) did.	Sodium Chloride	259-265	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
9344494-0	1997	Cocaine inhibits human endothelial cell IL-8 production: the role of transforming growth factor-beta.	Cocaine	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
9344494-4	1997	We investigated the effect of cocaine on endothelial cell IL-8 production.	Cocaine	30-37	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
9344494-6	1997	Cocaine decreased IL-8 production in a dose-responsive manner, and this reduction correlated with down-regulation of IL-8 mRNA expression.	Cocaine	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
9344494-6	1997	Cocaine decreased IL-8 production in a dose-responsive manner, and this reduction correlated with down-regulation of IL-8 mRNA expression.	Cocaine	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
9344494-7	1997	Cocaine also increased the production of TGF-beta by EA.hy 926 cells and anti-TGF-beta abrogated the cocaine-mediated decrement of IL-8 production, indicating that cocaine down-regulates endothelial IL-8 production by increasing TGF-beta.	Cocaine	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
9344494-7	1997	Cocaine also increased the production of TGF-beta by EA.hy 926 cells and anti-TGF-beta abrogated the cocaine-mediated decrement of IL-8 production, indicating that cocaine down-regulates endothelial IL-8 production by increasing TGF-beta.	Cocaine	101-108	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
9344494-7	1997	Cocaine also increased the production of TGF-beta by EA.hy 926 cells and anti-TGF-beta abrogated the cocaine-mediated decrement of IL-8 production, indicating that cocaine down-regulates endothelial IL-8 production by increasing TGF-beta.	Cocaine	101-108	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
9359732-2	1997	CNI-1493 inhibited lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta, IL-6, and IL-8 production whether or not LPS stimulation was enhanced by interferon (IFN)-gamma priming.	semapimod	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
9334359-0	1997	Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis.	Oxygen	33-39	C-X-C motif chemokine ligand 8	Homo sapiens	16-29
9334359-8	1997	These results support a model where IL-8 expression is initiated early in astrocytoma development through induction by inflammatory stimuli and later in tumor progression increases due to reduced microenvironmental oxygen pressure.	Oxygen	215-221	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
9352014-0	1997	Regulation of interleukin (IL)-6 and IL-8 production in an amnion-derived cell line by cytokines, growth factors, glucocorticoids, and phorbol esters.	Phorbol Esters	135-149	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
9352014-6	1997	Basal and cytokine-stimulated IL-6 and IL-8 production was inhibited by dexamethasone at concentrations equal to or greater than 1 nM.	Dexamethasone	72-85	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
9357758-2	1997	We characterized the mechanisms by which hyaluronic acid (HA) regulates interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-8 (IL-8) production in human uterine fibroblasts.	Hyaluronic Acid	41-56	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
9357758-2	1997	We characterized the mechanisms by which hyaluronic acid (HA) regulates interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-8 (IL-8) production in human uterine fibroblasts.	Hyaluronic Acid	58-60	C-X-C motif chemokine ligand 8	Homo sapiens	147-160
9357758-2	1997	We characterized the mechanisms by which hyaluronic acid (HA) regulates interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-8 (IL-8) production in human uterine fibroblasts.	Hyaluronic Acid	58-60	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
9395111-5	1997	If the globules formed may be described as "calcium fluoride like material", the additional information of this experiment is that, after interaction with neutral solutions, they also contain considerable amounts of NaF.	Calcium Fluoride	44-60	C-X-C motif chemokine ligand 8	Homo sapiens	216-219
9383257-3	1997	Histamine is a potent activator of endothelial cells (EC): it induces the expression of P-selectin on the surface of endothelium and the secretion of IL-6 and IL-8.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
9383257-7	1997	L and DCL inhibited significantly IL-6 and IL-8 secretion induced by histamine with a more powerful efficiency of the active metabolite.	Histamine	69-78	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
9383257-9	1997	Similar results were obtained for IL-8 (IC50 = 0.2 x 10[-6] M for L and 10[-9] M for DCL).	des(ethoxycarbonyl)loratadine	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
9321519-15	1997	The inhibitors BNPP (360 microM) and NaF (500 microM) inhibited alpha-naphthol formation to 9-10% of control and to 14-20% of control, respectively.	1-naphthol	64-78	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
9335957-3	1997	Cholesterol loading in macrophages was found to induce interleukin-8 expression, suggesting an association between foam cell formation and beta 2-integrin-dependent adhesion of leukocytes.	Cholesterol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	55-68
9356189-7	1997	Zinc oxide exposure was a statistically significant, dose-dependent predictor of increases in BAL TNF (mean exposure-sham difference +/- SE = 9.5 +/- 3.6 pg/mL, P = 0.02), IL-6 (mean exposure-sham difference +/- SE = 5.5 +/- 1.8 pg/mL, P = 0.009), and IL-8 (mean exposure-sham difference +/- SE = 64.1 +/- 23.9 pg/mL, P = 0.02).	Zinc Oxide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	252-256
9338624-7	1997	Bilirubin levels, at day of IL-8 peak, did not differ statistically between mild and severe VOD.	Bilirubin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
9344885-7	1997	NHBE cells exposed to ROFA produced significant amounts of IL-8, IL-6, and TNF, as well as mRNAs coding for these cytokines.	rofa	22-26	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
9349985-6	1997	CsA (1, 5, and 10ng/ml) significantly reduced IL-1 beta-induced IL-8 production (by 32%, 41%, and 48%, respectively), and reduced TNF alpha-induced IL-8 production (by 21%, 42%, and 50%, respectively).	Cyclosporine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
9349985-6	1997	CsA (1, 5, and 10ng/ml) significantly reduced IL-1 beta-induced IL-8 production (by 32%, 41%, and 48%, respectively), and reduced TNF alpha-induced IL-8 production (by 21%, 42%, and 50%, respectively).	Cyclosporine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
9349985-8	1997	The expression of IL-8 mRNA was also inhibited by CsA.	Cyclosporine	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
9357022-19	1997	A negative correlation was recognized between the patient plasma Gln level and the Gln 1000/Gln 500 ratio of the cell culture supernatant IL-8 level (r = -0.73, P = 0.025).	Glutamine	65-68	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
9357022-19	1997	A negative correlation was recognized between the patient plasma Gln level and the Gln 1000/Gln 500 ratio of the cell culture supernatant IL-8 level (r = -0.73, P = 0.025).	Glutamine	83-86	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
9357022-19	1997	A negative correlation was recognized between the patient plasma Gln level and the Gln 1000/Gln 500 ratio of the cell culture supernatant IL-8 level (r = -0.73, P = 0.025).	Glutamine	83-86	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
9363923-3	1997	IL-8 secretion increased in a time-dependent manner throughout the 24 h of observation; in contrast, EDN release reached a plateau value after 12 h. Furthermore, at least 2 microM ionomycin was necessary for induction of IL-8 secretion, whereas 0.5 microM induced detectable EDN release by eosinophils.	Ionomycin	180-189	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9363923-3	1997	IL-8 secretion increased in a time-dependent manner throughout the 24 h of observation; in contrast, EDN release reached a plateau value after 12 h. Furthermore, at least 2 microM ionomycin was necessary for induction of IL-8 secretion, whereas 0.5 microM induced detectable EDN release by eosinophils.	Ionomycin	180-189	C-X-C motif chemokine ligand 8	Homo sapiens	221-225
9349985-3	1997	The effects of cyclosporine A (CsA), tacrolimus (FK506), and dexamethasone (DEX) on cytokine-induced production of interleukin (IL)-8 in a human colonic cancer cell line (HT-29) were examined.	Cyclosporine	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	115-133
9349985-3	1997	The effects of cyclosporine A (CsA), tacrolimus (FK506), and dexamethasone (DEX) on cytokine-induced production of interleukin (IL)-8 in a human colonic cancer cell line (HT-29) were examined.	Tacrolimus	37-47	C-X-C motif chemokine ligand 8	Homo sapiens	115-133
9349985-3	1997	The effects of cyclosporine A (CsA), tacrolimus (FK506), and dexamethasone (DEX) on cytokine-induced production of interleukin (IL)-8 in a human colonic cancer cell line (HT-29) were examined.	Tacrolimus	49-54	C-X-C motif chemokine ligand 8	Homo sapiens	115-133
9349985-3	1997	The effects of cyclosporine A (CsA), tacrolimus (FK506), and dexamethasone (DEX) on cytokine-induced production of interleukin (IL)-8 in a human colonic cancer cell line (HT-29) were examined.	Dexamethasone	61-74	C-X-C motif chemokine ligand 8	Homo sapiens	115-133
9349985-3	1997	The effects of cyclosporine A (CsA), tacrolimus (FK506), and dexamethasone (DEX) on cytokine-induced production of interleukin (IL)-8 in a human colonic cancer cell line (HT-29) were examined.	Dexamethasone	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	115-133
9305861-2	1997	Using a mouse lymphoid cell line transfected with human formyl peptide or interleukin-8 receptors and normal human neutrophils as models, we show that cAMP functions as a gating element on the chemoattractant-induced rho-dependent signaling pathway leading to leukocyte integrin activation and adhesion.	Cyclic AMP	151-155	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
9350989-0	1997	Intracellular Ca2+ dependence of nitric oxide mediated enhancement of interleukin-8 secretion in human endothelial cells.	Nitric Oxide	33-45	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
9350989-5	1997	Sodium nitroprusside (SNP) and S-nitroso-N-acetyl-DL-penicillamine (SNAP) dose dependently increased IL-8 production in this cell type.	Nitroprusside	0-20	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
9350989-5	1997	Sodium nitroprusside (SNP) and S-nitroso-N-acetyl-DL-penicillamine (SNAP) dose dependently increased IL-8 production in this cell type.	snap	31-66	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
9350989-5	1997	Sodium nitroprusside (SNP) and S-nitroso-N-acetyl-DL-penicillamine (SNAP) dose dependently increased IL-8 production in this cell type.	snap	68-72	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
9350989-11	1997	SKF 96365, which has been shown to block receptor mediated Ca2+ entry, and TMB-8, which blocks intracellular Ca2+ release, both inhibited IL-8 secretion, particularly when TNFalpha was used as a costimulator, indicating that [Ca2+]i changes are important components of IL-8 induction by NO..	1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
9350989-11	1997	SKF 96365, which has been shown to block receptor mediated Ca2+ entry, and TMB-8, which blocks intracellular Ca2+ release, both inhibited IL-8 secretion, particularly when TNFalpha was used as a costimulator, indicating that [Ca2+]i changes are important components of IL-8 induction by NO..	1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	269-273
9350989-11	1997	SKF 96365, which has been shown to block receptor mediated Ca2+ entry, and TMB-8, which blocks intracellular Ca2+ release, both inhibited IL-8 secretion, particularly when TNFalpha was used as a costimulator, indicating that [Ca2+]i changes are important components of IL-8 induction by NO..	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	75-80	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
9350989-11	1997	SKF 96365, which has been shown to block receptor mediated Ca2+ entry, and TMB-8, which blocks intracellular Ca2+ release, both inhibited IL-8 secretion, particularly when TNFalpha was used as a costimulator, indicating that [Ca2+]i changes are important components of IL-8 induction by NO..	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	75-80	C-X-C motif chemokine ligand 8	Homo sapiens	269-273
9373700-6	1997	Milk from the alcohol group contained an elevated amount of IL-8 as compared with milk from non-smoker controls; however, it did not differ statistically from that of the smoker controls.	Alcohols	14-21	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
9373700-7	1997	Blood from the alcohol group showed an increased level of IL-8 when compared with that from both smoker and non-smoker controls.	Alcohols	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
9373700-12	1997	The present study found that alcohol consumption during pregnancy could modulate the production of IL-8 and infiltration of certain leukocytes in milk and blood of postpartum women.	Alcohols	29-36	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
9316497-6	1997	Staurosporine reduced the downmodulation by low-level IL-8 plus LTB4 or IL-1 beta but not by high-level IL-8 alone.	Staurosporine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
9316497-6	1997	Staurosporine reduced the downmodulation by low-level IL-8 plus LTB4 or IL-1 beta but not by high-level IL-8 alone.	Staurosporine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
9360082-5	1997	Levels of HA and IL-8 had good correlation with the level of TB (HA: r = 0.60, p &lt; 0.05; IL-8: r = 0.55, p &lt; 0.05).	Bilirubin	61-63	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
9322640-7	1997	Also, we found that incubation of decidual cells with various concentrations of lipoteichoic acid, sialic acid, lipopolysaccharide, and lipid A resulted in significant concentration-dependent increases in decidual cell macrophage inflammatory protein-1 alpha and interleukin-8 production (p &lt; 0.05.)	lipoteichoic acid	80-97	C-X-C motif chemokine ligand 8	Homo sapiens	263-276
9322640-7	1997	Also, we found that incubation of decidual cells with various concentrations of lipoteichoic acid, sialic acid, lipopolysaccharide, and lipid A resulted in significant concentration-dependent increases in decidual cell macrophage inflammatory protein-1 alpha and interleukin-8 production (p &lt; 0.05.)	N-Acetylneuraminic Acid	99-110	C-X-C motif chemokine ligand 8	Homo sapiens	263-276
9322640-7	1997	Also, we found that incubation of decidual cells with various concentrations of lipoteichoic acid, sialic acid, lipopolysaccharide, and lipid A resulted in significant concentration-dependent increases in decidual cell macrophage inflammatory protein-1 alpha and interleukin-8 production (p &lt; 0.05.)	Lipid A	136-143	C-X-C motif chemokine ligand 8	Homo sapiens	263-276
9360082-5	1997	Levels of HA and IL-8 had good correlation with the level of TB (HA: r = 0.60, p &lt; 0.05; IL-8: r = 0.55, p &lt; 0.05).	Bilirubin	61-63	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
9271387-0	1997	Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter.	Paclitaxel	33-43	C-X-C motif chemokine ligand 8	Homo sapiens	90-103
9302649-0	1997	1,25-Dihydroxyvitamin D3 and a new analogue, 22-oxacalcitriol, modulate proliferation and interleukin-8 secretion of normal human keratinocytes.	Calcitriol	0-24	C-X-C motif chemokine ligand 8	Homo sapiens	90-103
9302649-0	1997	1,25-Dihydroxyvitamin D3 and a new analogue, 22-oxacalcitriol, modulate proliferation and interleukin-8 secretion of normal human keratinocytes.	maxacalcitol	45-61	C-X-C motif chemokine ligand 8	Homo sapiens	90-103
9302649-3	1997	The present study was conducted to determine whether a new vitamin D3 analogue, 22-oxacalcitriol, could be effective in inhibiting the proliferation and IL-8 secretion of normal human epidermal keratinocytes.	Cholecalciferol	59-69	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
9302649-3	1997	The present study was conducted to determine whether a new vitamin D3 analogue, 22-oxacalcitriol, could be effective in inhibiting the proliferation and IL-8 secretion of normal human epidermal keratinocytes.	maxacalcitol	80-96	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
9302649-6	1997	Proliferation of cultured normal human epidermal keratinocytes was inhibited in the presence of 1,25-dihydroxyvitamin D3 at the concentrations of 1 x 10(-8) to 1 x 10(-6) M and 22-oxacalcitriol at concentrations of more than 1 x 10(-9) M at 48 h. IL-8 secretion from normal human epidermal keratinocytes was augmented by TNF-alpha, or synergistically by TNF-alpha and IFN-gamma.	Calcitriol	96-120	C-X-C motif chemokine ligand 8	Homo sapiens	247-251
9302649-7	1997	1,25-Dihydroxyvitamin D3 and 22-oxacalcitriol inhibited cytokine-stimulated IL-8 production dose dependently after 24 h incubation without inhibition of cell proliferation.	Calcitriol	0-24	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
9302649-7	1997	1,25-Dihydroxyvitamin D3 and 22-oxacalcitriol inhibited cytokine-stimulated IL-8 production dose dependently after 24 h incubation without inhibition of cell proliferation.	maxacalcitol	29-45	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
9302649-8	1997	1,25-Dihydroxyvitamin D3 and 22-oxacalcitriol are considered to inhibit the proliferation of keratinocytes directly and indirectly with inhibition of the secretion of IL-8 from keratinocytes.	Calcitriol	0-24	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
9302649-8	1997	1,25-Dihydroxyvitamin D3 and 22-oxacalcitriol are considered to inhibit the proliferation of keratinocytes directly and indirectly with inhibition of the secretion of IL-8 from keratinocytes.	maxacalcitol	29-45	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
9302649-9	1997	The inhibition of IL-8 secretion from keratinocytes by vitamin D3 could modulate the behaviour of immunocompetent cells infiltrating in the skin.	Cholecalciferol	55-65	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
9292787-0	1997	Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	53-66
9292787-0	1997	Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells.	Flavonoids	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	53-66
9298535-11	1997	Pretreatment with L-NAME significantly enhanced the TNF-alpha (10(3) u)-induced neutrophil recruitment and human IL-8 equivalents production at 6 h, but not at 1 h of TNF-alpha administration (early phase).	NG-Nitroarginine Methyl Ester	18-24	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
9400717-7	1997	In addition to a TNF-alpha-mediated pathway, there is growing evidence that some particles such as quartz and crocidolite can directly activate lung epithelial cells to release chemokines such as macrophage inflammatory protein-2, cytokine-induced neutrophil chemoattractant, and interleukin-8.	Asbestos, Crocidolite	110-121	C-X-C motif chemokine ligand 8	Homo sapiens	280-293
9310121-5	1997	Furthermore, MTX caused a significant inhibition of both superoxide production induced by phorbol 12-myristate-13-acetate and chemotaxis induced by interleukin 8 in G-CSF-primed neutrophils.	Methotrexate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	148-161
9292787-6	1997	RESULTS: Addition of quercetin suppressed TNF-alpha induced increase in the mRNA for IL-8 and MCP-1 in a dose dependent manner.	Quercetin	21-30	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
9292787-8	1997	H2O2 mediated induction of IL-8 and MCP-1 genes was also inhibited by quercetin.	Hydrogen Peroxide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
9292787-8	1997	H2O2 mediated induction of IL-8 and MCP-1 genes was also inhibited by quercetin.	Quercetin	70-79	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
9292787-10	1997	CONCLUSION: Quercetin suppresses TNF-alpha mediated stimulation of IL-8 and MCP-1 expression, at least in part, by inhibiting the activation of NF-kappa B.	Quercetin	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
9271387-0	1997	Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter.	Paclitaxel	45-50	C-X-C motif chemokine ligand 8	Homo sapiens	90-103
9271387-3	1997	Previously, we demonstrated that paclitaxel can induce interleukin-8 (IL-8) gene expression at the transcriptional level in subsets of human ovarian cancer lines.	Paclitaxel	33-43	C-X-C motif chemokine ligand 8	Homo sapiens	55-68
9271387-3	1997	Previously, we demonstrated that paclitaxel can induce interleukin-8 (IL-8) gene expression at the transcriptional level in subsets of human ovarian cancer lines.	Paclitaxel	33-43	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
9271387-6	1997	Paclitaxel only activated the IL-8 promoter in responsive cells.	Paclitaxel	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
9271387-7	1997	The AP-1 and NF-kappaB binding sites in the IL-8 promoter are required for activation by paclitaxel; in contrast, a C/EBP site required for IL-8 promoter activation in other cell types is not involved.	Paclitaxel	89-99	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
9271387-10	1997	These results demonstrate a molecular mechanism for cell-specific paclitaxel-induced IL-8 gene expression which may have clinical relevance.	Paclitaxel	66-76	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
9267955-0	1997	Effect of ciprofloxacin on the accumulation of interleukin-6, interleukin-8, and nitrite from a human endothelial cell model of sepsis.	Ciprofloxacin	10-23	C-X-C motif chemokine ligand 8	Homo sapiens	62-75
9279218-5	1997	In BW, exposure to NO2 induced a 1.5-fold increase in interleukin-8 (IL-8) (p &lt; 0.05) at 1.5 h and a 2.5-fold increase in neutrophils (p &lt; 0.01) at 6 h. In BAL fluid (BALF), small increases were observed in CD45RO+ lymphocytes, B-cells, and natural killer (NK) cells only.	Nitrogen Dioxide	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
9279218-5	1997	In BW, exposure to NO2 induced a 1.5-fold increase in interleukin-8 (IL-8) (p &lt; 0.05) at 1.5 h and a 2.5-fold increase in neutrophils (p &lt; 0.01) at 6 h. In BAL fluid (BALF), small increases were observed in CD45RO+ lymphocytes, B-cells, and natural killer (NK) cells only.	Nitrogen Dioxide	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
9245487-3	1997	In the present study, using FITC-IL-8 conjugate as a probe, we have demonstrated the time- and temperature-dependent endocytosis of IL-8 under fluorescent microscope.	Fluorescein-5-isothiocyanate	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
9245487-3	1997	In the present study, using FITC-IL-8 conjugate as a probe, we have demonstrated the time- and temperature-dependent endocytosis of IL-8 under fluorescent microscope.	Fluorescein-5-isothiocyanate	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
9267955-8	1997	Interleukin-8 was decreased at lower ciprofloxacin concentrations (p = .017) but was increased at 100 microg/mL (p = .0039).	Ciprofloxacin	37-50	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
9245487-5	1997	Monodansyl cadaverine (MDC, 900 microM), however, was found to retain the fluorescent light of FITC coupled with Il-8 on the cells.	monodansylcadaverine	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
9245487-5	1997	Monodansyl cadaverine (MDC, 900 microM), however, was found to retain the fluorescent light of FITC coupled with Il-8 on the cells.	monodansylcadaverine	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
9267955-10	1997	CONCLUSIONS: Ciprofloxacin differentially modulates interleukin-6 and interleukin-8 expression.	Ciprofloxacin	13-26	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
9245487-7	1997	With respect to control, IL-8 induced biological responses e.g. IL-8 directed migration, intracellular Ca2+ release and superoxide release are significantly reduced by 77%, 94% and 76%, respectively, in presence of MDC.	Superoxides	120-130	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
9293391-0	1997	Differential modulation of IL-8 and TNF-alpha expression in human keratinocytes by buflomedil chlorhydrate and pentoxifylline.	buflomedil chlorhydrate	83-106	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
9293391-0	1997	Differential modulation of IL-8 and TNF-alpha expression in human keratinocytes by buflomedil chlorhydrate and pentoxifylline.	Pentoxifylline	111-125	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
9293391-7	1997	TPA-induced TNF-alpha and IL-8 release from keratinocytes.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
9293391-9	1997	TPA increased RNA expression of the TNF-alpha, IL-1 alpha, IL-1 beta, IL-8 and TGF-beta 1.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
9293391-10	1997	BC diminished TPA-induced TNF-alpha and IL-8 release from keratinocytes; in the case of IL-8 it is possible that this inhibition occur to transcriptional level.	Tetradecanoylphorbol Acetate	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
9233596-3	1997	By introducing the N-terminal mutation delta1-5,ELR&gt;AAR into CINC, we have developed a rat alpha-chemokine receptor antagonist (ra) analogous to a previously described mutant of human IL-8.	Zinc	64-68	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
9258252-1	1997	Interleukin-8 (IL-8) is an important cytokine in inflammatory processes by functioning as a chemoattractant and as an activator of oxygen metabolism.	Oxygen	131-137	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
9258252-1	1997	Interleukin-8 (IL-8) is an important cytokine in inflammatory processes by functioning as a chemoattractant and as an activator of oxygen metabolism.	Oxygen	131-137	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
9258252-6	1997	The effect of the beta 2-adrenergic agonist on IL-8 production is presumably mediated via increased cAMP formation, since it can be mimicked by the cAMP analogue dibutyryl-cAMP (db-cAMP).	Cyclic AMP	100-104	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
9258252-6	1997	The effect of the beta 2-adrenergic agonist on IL-8 production is presumably mediated via increased cAMP formation, since it can be mimicked by the cAMP analogue dibutyryl-cAMP (db-cAMP).	Cyclic AMP	148-152	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
9258252-6	1997	The effect of the beta 2-adrenergic agonist on IL-8 production is presumably mediated via increased cAMP formation, since it can be mimicked by the cAMP analogue dibutyryl-cAMP (db-cAMP).	Bucladesine	162-176	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
9258252-6	1997	The effect of the beta 2-adrenergic agonist on IL-8 production is presumably mediated via increased cAMP formation, since it can be mimicked by the cAMP analogue dibutyryl-cAMP (db-cAMP).	Bucladesine	178-185	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
9258252-7	1997	We conclude that enhancement of IL-8 production is one of the pathways via which beta 2-adrenergic agonists such as catecholamines can influence inflammatory responses.	Catecholamines	116-130	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
9236347-6	1997	The tepid group showed an earlier decrease in interleukin-8 and neutrophil elastase levels as compared with the hypothermic group.	tepid	4-9	C-X-C motif chemokine ligand 8	Homo sapiens	46-59
9263137-3	1997	RESULTS: In MNC and synovial fibroblast cultures dexamethasone, GSTM, and PGE2 most markedly downregulated spontaneous and/or cytokine stimulated production of IL-1 beta, IL-14a, IL-8, and MCP-1, whereas sTNFR shedding was not affected.	Dexamethasone	49-62	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
20654323-4	1997	The unsaturated fatty acids increased both TEWL and LDV and elevated IL-1alpha and IL-8 mRNA levels, whereas their effects on protein levels were minimal.	Fatty Acids, Unsaturated	4-27	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
9253958-2	1997	Anandamide was shown to diminish interleukin-6 and interleukin-8 production at low nanomolar concentrations (3-30 nM) but inhibited the production of TNF-alpha, interferon-gamma, interleukin-4 and p75 TNF-alpha soluble receptors at higher concentrations (0.3-3 microM).	anandamide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
9253958-3	1997	Palmitoylethanolamide inhibited interleukin-4, interleukin-6, interleukin-8 synthesis and the production of p75 TNF-alpha soluble receptors at concentrations similar to those of anandamide but failed to influence TNF-alpha and interferon-gamma production.	palmidrol	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	62-75
9228216-6	1997	The immunoreactivity of markers for epidermal proliferation and differentiation, as well as of CD1a and NAP-1/IL-8, changed after 8 weeks of calcitriol treatment almost completely to the pattern characteristic for non-lesional psoriatic skin, while a large number of 55 kDa TNF-receptor positive cells could be found in the dermal compartment.	Calcitriol	141-151	C-X-C motif chemokine ligand 8	Homo sapiens	104-109
9228216-6	1997	The immunoreactivity of markers for epidermal proliferation and differentiation, as well as of CD1a and NAP-1/IL-8, changed after 8 weeks of calcitriol treatment almost completely to the pattern characteristic for non-lesional psoriatic skin, while a large number of 55 kDa TNF-receptor positive cells could be found in the dermal compartment.	Calcitriol	141-151	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
9263137-3	1997	RESULTS: In MNC and synovial fibroblast cultures dexamethasone, GSTM, and PGE2 most markedly downregulated spontaneous and/or cytokine stimulated production of IL-1 beta, IL-14a, IL-8, and MCP-1, whereas sTNFR shedding was not affected.	Gold Sodium Thiomalate	64-68	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
9263137-3	1997	RESULTS: In MNC and synovial fibroblast cultures dexamethasone, GSTM, and PGE2 most markedly downregulated spontaneous and/or cytokine stimulated production of IL-1 beta, IL-14a, IL-8, and MCP-1, whereas sTNFR shedding was not affected.	Dinoprostone	74-78	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
9253958-7	1997	TNF-alpha, interleukin-6 and interleukin-8 synthesis was maximally inhibited by 3 nM delta9-tetrahydrocannabinol but stimulated by 3 microM delta9-tetrahydrocannabinol, as was interleukin-8 and interferon-gamma synthesis.	Dronabinol	85-112	C-X-C motif chemokine ligand 8	Homo sapiens	29-42
9253958-7	1997	TNF-alpha, interleukin-6 and interleukin-8 synthesis was maximally inhibited by 3 nM delta9-tetrahydrocannabinol but stimulated by 3 microM delta9-tetrahydrocannabinol, as was interleukin-8 and interferon-gamma synthesis.	Dronabinol	140-167	C-X-C motif chemokine ligand 8	Homo sapiens	29-42
9230759-0	1997	Erythromycin modulates IL-8 expression in normal and inflamed human bronchial epithelial cells.	Erythromycin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
9230759-4	1997	EM and clarithromycin (CAM) uniquely suppressed mRNA levels as well as the release of IL-8 at the therapeutic and noncytotoxic concentrations (% inhibition of IL-8 protein release: 25.0 +/- 5.67% and 37.5 +/- 8.99%, respectively, at 10(-6) M).	Erythromycin	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
9230759-4	1997	EM and clarithromycin (CAM) uniquely suppressed mRNA levels as well as the release of IL-8 at the therapeutic and noncytotoxic concentrations (% inhibition of IL-8 protein release: 25.0 +/- 5.67% and 37.5 +/- 8.99%, respectively, at 10(-6) M).	Clarithromycin	7-21	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
9230759-4	1997	EM and clarithromycin (CAM) uniquely suppressed mRNA levels as well as the release of IL-8 at the therapeutic and noncytotoxic concentrations (% inhibition of IL-8 protein release: 25.0 +/- 5.67% and 37.5 +/- 8.99%, respectively, at 10(-6) M).	Clarithromycin	7-21	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
9230759-4	1997	EM and clarithromycin (CAM) uniquely suppressed mRNA levels as well as the release of IL-8 at the therapeutic and noncytotoxic concentrations (% inhibition of IL-8 protein release: 25.0 +/- 5.67% and 37.5 +/- 8.99%, respectively, at 10(-6) M).	Clarithromycin	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
9230759-7	1997	Among five patients who underwent bronchoscopy before and after macrolide treatment, four showed decreased levels of IL-8 expression in airway epithelium as assessed by reverse transcription and polymerase chain reaction.	Macrolides	64-73	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
9266021-0	1997	The demonstration of serum interleukin-8 and superoxide dismutase in Adamantiades-Behcet"s disease.	adamantiades	69-81	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
9268748-8	1997	Preincubation on normal neutrophils with the patients" sera caused an increase in their superoxide generation in accordance with the high IL-8 levels in these sera.	Superoxides	88-98	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
19856299-1	1997	This study demonstrates the changing levels of leukotrieneB4 (LTB4) and leukotrieneC4 (LTC4) generated by human white blood cells primed with different human interleukins IL-3, IL-5, IL-6, IL-8 and with human hematopoietic growth factor granulocyte-macrophage colony stimulating factor (GM-CSF).	Leukotriene B4	47-60	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
19856299-1	1997	This study demonstrates the changing levels of leukotrieneB4 (LTB4) and leukotrieneC4 (LTC4) generated by human white blood cells primed with different human interleukins IL-3, IL-5, IL-6, IL-8 and with human hematopoietic growth factor granulocyte-macrophage colony stimulating factor (GM-CSF).	Leukotriene C4	72-85	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
9240177-1	1997	OBJECTIVE: To determine the effects of isoniazid (isonicotinic acid hydrazide), used to reduce the serious side-effects of immunotherapy of superficial bladder cancer with bacille Calmette-Guerin (BCG), on the proliferation and constitutive BCG-induced synthesis of interleukins 6 (IL6) and 8 (IL8) in human bladder cancer cells cultured in vitro.	Isoniazid	39-48	C-X-C motif chemokine ligand 8	Homo sapiens	294-297
9240177-1	1997	OBJECTIVE: To determine the effects of isoniazid (isonicotinic acid hydrazide), used to reduce the serious side-effects of immunotherapy of superficial bladder cancer with bacille Calmette-Guerin (BCG), on the proliferation and constitutive BCG-induced synthesis of interleukins 6 (IL6) and 8 (IL8) in human bladder cancer cells cultured in vitro.	Isoniazid	50-77	C-X-C motif chemokine ligand 8	Homo sapiens	294-297
9284961-1	1997	Relatively high concentrations of azathioprine had an inhibitory effect on interleukin 8 (IL-8)- or formyl-methionyl-leucyl-phenylalanine-activated (fMLP)-chemotaxis by human neutrophils.	Azathioprine	34-46	C-X-C motif chemokine ligand 8	Homo sapiens	75-88
9284961-1	1997	Relatively high concentrations of azathioprine had an inhibitory effect on interleukin 8 (IL-8)- or formyl-methionyl-leucyl-phenylalanine-activated (fMLP)-chemotaxis by human neutrophils.	Azathioprine	34-46	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
9284961-6	1997	High concentrations of azathioprine (1 mM) inhibited CD11b expression of fMLP- or IL-8- activated neutrophils; the latter could explain the inhibitory effect of azathioprine.	Azathioprine	23-35	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
9284961-6	1997	High concentrations of azathioprine (1 mM) inhibited CD11b expression of fMLP- or IL-8- activated neutrophils; the latter could explain the inhibitory effect of azathioprine.	Azathioprine	161-173	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
9284961-9	1997	The antagonists had only a marginal effect on inhibition of IL-8-activated chemotaxis by high concentrations of azathioprine, thus the G-kinase seems not to be of great importance on the inhibitory effect of azathioprine.	Azathioprine	112-124	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
9237814-1	1997	The aim of this study was to investigate the roles of protein kinase A (PKA), protein kinase C (PKC), protein tyrosine kinase (PTK) and intracellular calcium in the induction of IL-8 production by gastric epithelial cells.	Calcium	150-157	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
9237814-6	1997	Activation of PKC by phorbol myristate acetate was also an effective stimulus to IL-8 production and this was blocked by PKC depletion or inhibitors.	Tetradecanoylphorbol Acetate	21-46	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
9237814-9	1997	The calcium ionophore A23187 was a weak, PKC dependent, stimulant of IL-8 production.	Calcium	4-11	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
9237814-9	1997	The calcium ionophore A23187 was a weak, PKC dependent, stimulant of IL-8 production.	Calcimycin	22-28	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
9223588-0	1997	The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-kappaB.	hymenialdisine	20-34	C-X-C motif chemokine ligand 8	Homo sapiens	44-57
9212819-5	1997	In this way, we were able to detect IL-8 with a monoclonal antibody in stimulated cells that were microwave-fixed with a combination of paraformaldehyde (4%) and glutaraldehyde (0.1%), followed by permeabilization with saponin (0.025%).	paraform	136-152	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
9212819-5	1997	In this way, we were able to detect IL-8 with a monoclonal antibody in stimulated cells that were microwave-fixed with a combination of paraformaldehyde (4%) and glutaraldehyde (0.1%), followed by permeabilization with saponin (0.025%).	Glutaral	162-176	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
9212819-5	1997	In this way, we were able to detect IL-8 with a monoclonal antibody in stimulated cells that were microwave-fixed with a combination of paraformaldehyde (4%) and glutaraldehyde (0.1%), followed by permeabilization with saponin (0.025%).	Saponins	219-226	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
9223588-8	1997	Functional studies showed hymenialdisine to be an inhibitor of IL-8 production and IL-8 mRNA formation in the U937 cell.	hymenialdisine	26-40	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
9223588-8	1997	Functional studies showed hymenialdisine to be an inhibitor of IL-8 production and IL-8 mRNA formation in the U937 cell.	hymenialdisine	26-40	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
9223588-11	1997	Thus, hymenialdisine is a potent inhibitor of NF-kappaB and IL-8 production in U937 cells.	hymenialdisine	6-20	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
9507569-7	1997	Exposure of cyclosporin A and dexamethasone almost completely inhibited the production of IL-6 and IL-8 after 24 hours of treatment.	Cyclosporine	12-25	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
9252959-10	1997	ET-18-OCH3 uptake in the HL-60 cell line was also more sensitive to treatment with endocytic (chloroquine, monensin) or metabolic (NaF, KCN) inhibitors.	et-18	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
9252959-10	1997	ET-18-OCH3 uptake in the HL-60 cell line was also more sensitive to treatment with endocytic (chloroquine, monensin) or metabolic (NaF, KCN) inhibitors.	och3	6-10	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
9199336-7	1997	Administration of a NF-kappaB antisense oligonucleotide almost completely inhibited TNF-alpha-dependent IL-8 production and partially abrogated TNF-alpha-dependent VEGF production, and an Sp1 antisense sequence partially inhibited TNF-alpha-dependent production of VEGF.	Oligonucleotides	40-55	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
9507569-7	1997	Exposure of cyclosporin A and dexamethasone almost completely inhibited the production of IL-6 and IL-8 after 24 hours of treatment.	Dexamethasone	30-43	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
9182566-0	1997	Stimulation of interleukin-8 production by okadaic acid and vanadate in a human promyelocyte cell line, an HL-60 subline.	Okadaic Acid	43-55	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
9182566-0	1997	Stimulation of interleukin-8 production by okadaic acid and vanadate in a human promyelocyte cell line, an HL-60 subline.	Vanadates	60-68	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
9182566-7	1997	IL-8 production by OA or VA was inhibited by protein kinase inhibitors, including staurosporine, H-7, K252a, herbimycin A, and genistein.	Vanillic Acid	25-27	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9182566-7	1997	IL-8 production by OA or VA was inhibited by protein kinase inhibitors, including staurosporine, H-7, K252a, herbimycin A, and genistein.	Staurosporine	82-95	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9182566-7	1997	IL-8 production by OA or VA was inhibited by protein kinase inhibitors, including staurosporine, H-7, K252a, herbimycin A, and genistein.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	97-100	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9182566-7	1997	IL-8 production by OA or VA was inhibited by protein kinase inhibitors, including staurosporine, H-7, K252a, herbimycin A, and genistein.	staurosporine aglycone	102-107	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9182566-7	1997	IL-8 production by OA or VA was inhibited by protein kinase inhibitors, including staurosporine, H-7, K252a, herbimycin A, and genistein.	herbimycin	109-121	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9182566-7	1997	IL-8 production by OA or VA was inhibited by protein kinase inhibitors, including staurosporine, H-7, K252a, herbimycin A, and genistein.	Genistein	127-136	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9176395-9	1997	Preincubation of HUVECs with pyrrolidine dithiocarbamate prevented MAC-induced increases in IL-8 and MCP-1 mRNA concentrations and protein secretion.	pyrrolidine dithiocarbamic acid	29-56	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
9215025-9	1997	Nitric oxide and superoxide have profound effects on IL-8.	Superoxides	17-27	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
9227164-1	1997	OBJECTIVE: To investigate whether administration of sodium fluoride (NaF) in addition to cyclical etidronate has a positive effect on bone mineral density (BMD) in patients with established osteoporosis during continued treatment with corticosteroids.	Sodium Fluoride	52-67	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
9227164-7	1997	RESULTS: After two years of treatment, the BMD of the lumbar spine in the etidronate/NaF group had increased by +9.3% (95% confidence intervals (CI): +2.3% to +16.2%, p &lt; 0.01), while the BMD in the etidronate/placebo group was unchanged: +0.3% (95% CI: -2.2% to +2.8%).	Etidronic Acid	202-212	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
9227164-12	1997	CONCLUSION: The effect of combination treatment with NaF and etidronate on the BMD of the lumbar spine in corticosteroid treated patients with established osteoporosis is superior to that of etidronate alone.	Etidronic Acid	191-201	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
9215025-0	1997	Effect of exogenous nitric oxide and superoxide on interleukin-8 from human polymorphonuclear leucocytes.	Nitric Oxide	20-32	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
9192939-7	1997	In contrast, DTT-treated sputum had higher total cell counts (median 8.8 vs 2.8 x 10(6) mL(-1); p&lt;0.001) and levels of ECP (median 1340 vs 584 mg x L(-1); p&lt;0.001) The measurements were similar with respect to the proportion of eosinophils, neutrophils, lymphocytes, macrophages, and fluid-phase fibrinogen, IL-5 and IL-8.	Dithiothreitol	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	323-327
9215025-0	1997	Effect of exogenous nitric oxide and superoxide on interleukin-8 from human polymorphonuclear leucocytes.	Superoxides	37-47	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
9215025-6	1997	The combined nitric oxide-superoxide donor, 3-morpholinosydnonimine (SIN-1), dose-dependently decreased lipopolysaccharide-mediated IL-8 accumulation (P &lt; 0.01).	nitric oxide-superoxide	13-36	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
9215025-6	1997	The combined nitric oxide-superoxide donor, 3-morpholinosydnonimine (SIN-1), dose-dependently decreased lipopolysaccharide-mediated IL-8 accumulation (P &lt; 0.01).	linsidomine	44-67	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
9215025-8	1997	In contrast, the pure nitric oxide donor, 1,2,3,4-oxatriazolium 5-amino chloride (GEA-3162), increased stimulated IL-8 accumulation (P &lt; 0.01) and also increased IL-8 accumulation in unstimulated cells (P &lt; 0.002).	Nitric Oxide	22-34	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
9215025-8	1997	In contrast, the pure nitric oxide donor, 1,2,3,4-oxatriazolium 5-amino chloride (GEA-3162), increased stimulated IL-8 accumulation (P &lt; 0.01) and also increased IL-8 accumulation in unstimulated cells (P &lt; 0.002).	Nitric Oxide	22-34	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
9215025-8	1997	In contrast, the pure nitric oxide donor, 1,2,3,4-oxatriazolium 5-amino chloride (GEA-3162), increased stimulated IL-8 accumulation (P &lt; 0.01) and also increased IL-8 accumulation in unstimulated cells (P &lt; 0.002).	1,2,3,4-oxatriazolium 5-amino chloride	42-80	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
9215025-8	1997	In contrast, the pure nitric oxide donor, 1,2,3,4-oxatriazolium 5-amino chloride (GEA-3162), increased stimulated IL-8 accumulation (P &lt; 0.01) and also increased IL-8 accumulation in unstimulated cells (P &lt; 0.002).	1,2,3,4-oxatriazolium 5-amino chloride	42-80	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
9215025-8	1997	In contrast, the pure nitric oxide donor, 1,2,3,4-oxatriazolium 5-amino chloride (GEA-3162), increased stimulated IL-8 accumulation (P &lt; 0.01) and also increased IL-8 accumulation in unstimulated cells (P &lt; 0.002).	gea	82-85	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
9215025-8	1997	In contrast, the pure nitric oxide donor, 1,2,3,4-oxatriazolium 5-amino chloride (GEA-3162), increased stimulated IL-8 accumulation (P &lt; 0.01) and also increased IL-8 accumulation in unstimulated cells (P &lt; 0.002).	gea	82-85	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
9215025-9	1997	Nitric oxide and superoxide have profound effects on IL-8.	Nitric Oxide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
9225534-1	1997	OBJECTIVE: The study was designed to test the hypothesis that a dentifrice with fluoride at the same concentration (1000ppm) from two sources, ie NaF and NaMFP, would provide a greater treatment effect than one with NaMFP alone.	Fluorides	80-88	C-X-C motif chemokine ligand 8	Homo sapiens	146-149
9169777-0	1997	Lipopolysaccharide-induced interleukin 8 production by human whole blood is enhanced by epinephrine and inhibited by hydrocortisone.	Epinephrine	88-99	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
9437256-3	1997	The antioxidant effect of NAF was about 3 times less potent than that of alpha-tocopherol (alpha-TOC) in phosphatidylcholine liposomes, and NAF was about 2-4 times more efficient to decrease peroxidation of LDL than alpha-TOC.	Phosphatidylcholines	105-124	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
9437256-4	1997	Possible interaction of NAF with alpha-tocopherol radical (alpha-TR) was studied by EPR spectroscopy.	alpha-tocopherol radical	33-57	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
9222021-5	1997	Locally acting prostaglandins modulate vascular permeability, and a synergistic action of prostaglandin E (PGE) with IL-8 has been described.	Prostaglandins E	90-105	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
9222021-5	1997	Locally acting prostaglandins modulate vascular permeability, and a synergistic action of prostaglandin E (PGE) with IL-8 has been described.	Prostaglandins E	107-110	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
9169777-0	1997	Lipopolysaccharide-induced interleukin 8 production by human whole blood is enhanced by epinephrine and inhibited by hydrocortisone.	Hydrocortisone	117-131	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
9169777-2	1997	Epinephrine caused a dose-dependent increase in LPS-induced IL-8 production, which was mediated exclusively via beta-adrenergic receptors, as reflected by the facts that beta (but not alpha) receptor blockade reversed the epinephrine effect and beta (but not alpha) receptor stimulation reproduced the epinephrine effect.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
9169777-2	1997	Epinephrine caused a dose-dependent increase in LPS-induced IL-8 production, which was mediated exclusively via beta-adrenergic receptors, as reflected by the facts that beta (but not alpha) receptor blockade reversed the epinephrine effect and beta (but not alpha) receptor stimulation reproduced the epinephrine effect.	Epinephrine	222-233	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
9169777-2	1997	Epinephrine caused a dose-dependent increase in LPS-induced IL-8 production, which was mediated exclusively via beta-adrenergic receptors, as reflected by the facts that beta (but not alpha) receptor blockade reversed the epinephrine effect and beta (but not alpha) receptor stimulation reproduced the epinephrine effect.	Epinephrine	302-313	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
9169777-3	1997	Further, elevating cellular cyclic AMP (cAMP) concentrations, a known effect of beta-adrenergic stimulation, by addition of dibutyryl cAMP also enhanced LPS-induced IL-8 production.	Cyclic AMP	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
9169777-3	1997	Further, elevating cellular cyclic AMP (cAMP) concentrations, a known effect of beta-adrenergic stimulation, by addition of dibutyryl cAMP also enhanced LPS-induced IL-8 production.	Cyclic AMP	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
9169777-3	1997	Further, elevating cellular cyclic AMP (cAMP) concentrations, a known effect of beta-adrenergic stimulation, by addition of dibutyryl cAMP also enhanced LPS-induced IL-8 production.	Cyclic AMP	134-138	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
9169777-4	1997	Epinephrine-induced upregulation of IL-10 production masked an even more pronounced stimulating effect of this hormone on IL-8 synthesis, as indicated by the finding that the extent of IL-8 upregulation was greater in the presence of anti-IL-10 than in the absence of anti-IL-10.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
9169777-4	1997	Epinephrine-induced upregulation of IL-10 production masked an even more pronounced stimulating effect of this hormone on IL-8 synthesis, as indicated by the finding that the extent of IL-8 upregulation was greater in the presence of anti-IL-10 than in the absence of anti-IL-10.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
9169777-5	1997	Hydrocortisone dose-dependently inhibited LPS-induced IL-8 production and reversed epinephrine-induced enhancement of IL-8 production.	Hydrocortisone	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
9169777-5	1997	Hydrocortisone dose-dependently inhibited LPS-induced IL-8 production and reversed epinephrine-induced enhancement of IL-8 production.	Hydrocortisone	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
9169777-5	1997	Hydrocortisone dose-dependently inhibited LPS-induced IL-8 production and reversed epinephrine-induced enhancement of IL-8 production.	Epinephrine	83-94	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
9169777-6	1997	Epinephrine and hydrocortisone have opposite effects on IL-8 production, which may be relevant for the understanding of endogenous and therapeutic stress hormone influences on IL-8 mediated inflammation.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
9169777-6	1997	Epinephrine and hydrocortisone have opposite effects on IL-8 production, which may be relevant for the understanding of endogenous and therapeutic stress hormone influences on IL-8 mediated inflammation.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
9169777-6	1997	Epinephrine and hydrocortisone have opposite effects on IL-8 production, which may be relevant for the understanding of endogenous and therapeutic stress hormone influences on IL-8 mediated inflammation.	Hydrocortisone	16-30	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
9169777-6	1997	Epinephrine and hydrocortisone have opposite effects on IL-8 production, which may be relevant for the understanding of endogenous and therapeutic stress hormone influences on IL-8 mediated inflammation.	Hydrocortisone	16-30	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
9151824-6	1997	Although M-T7 retains binding to a number of interleukin-8 N-terminal (ELR) deletion mutants, binding to mutants containing deletions in the C-terminal heparin-binding domain of interleukin-8 is abrogated.	Heparin	152-159	C-X-C motif chemokine ligand 8	Homo sapiens	178-191
9201300-6	1997	IL-8 mRNA expressed by HT-29 cells in response to E. histolytica trophozoites was downregulated in the presence of galactose, N-acetylgalactosamine or N-acetyl-lactosamine (0.1-100 mM), and this was paralleled by decreased IL-8 protein secretion.	Galactose	115-124	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9217378-0	1997	[Effects of pre-operative administration of steroids on the serum interleukin (IL)-6, IL-8 and organ injuries in replacement of thoracic aorta].	Steroids	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
9217378-1	1997	To investigate whether pre-operative steroids administration decreases the post-operative serum IL-6, IL-8 and prevents organ injuries, we prospectively studied patients undergoing elective replacement of thoracic aorta using an extracorporeal circulation.	Steroids	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
9217378-4	1997	These findings show that in replacement of thoracic aorta, pre-operative steroid administration decreases the post-operative elevations of serum inflammatory cytokines (IL-6 and IL-8) and may prevent organ injuries.	Steroids	73-80	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
9201300-6	1997	IL-8 mRNA expressed by HT-29 cells in response to E. histolytica trophozoites was downregulated in the presence of galactose, N-acetylgalactosamine or N-acetyl-lactosamine (0.1-100 mM), and this was paralleled by decreased IL-8 protein secretion.	Acetylgalactosamine	126-147	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9261930-0	1997	Effects of long-term low-dose macrolide administration on neutrophil recruitment and IL-8 in the nasal discharge of chronic sinusitis patients.	Macrolides	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
9261930-6	1997	These findings suggest that long-term low-dose roxithromycin administration inhibits the positive feedback mechanism of neutrophil recruitment and IL-8 production by the recruited neutrophils, which is considered to be an essential cause of the prolongation of sinusitis.	Roxithromycin	47-60	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
9201300-6	1997	IL-8 mRNA expressed by HT-29 cells in response to E. histolytica trophozoites was downregulated in the presence of galactose, N-acetylgalactosamine or N-acetyl-lactosamine (0.1-100 mM), and this was paralleled by decreased IL-8 protein secretion.	N-acetyllactosamine	151-171	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9201300-6	1997	IL-8 mRNA expressed by HT-29 cells in response to E. histolytica trophozoites was downregulated in the presence of galactose, N-acetylgalactosamine or N-acetyl-lactosamine (0.1-100 mM), and this was paralleled by decreased IL-8 protein secretion.	N-acetyllactosamine	151-171	C-X-C motif chemokine ligand 8	Homo sapiens	223-227
9154890-6	1997	Two major volatile factors in cigarette smoke, acrolein and acetaldehyde, augmented IL-8 release.	Acrolein	47-55	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
9154890-6	1997	Two major volatile factors in cigarette smoke, acrolein and acetaldehyde, augmented IL-8 release.	Acetaldehyde	60-72	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
9145235-2	1997	In clinical trials, both treatments increase bone density, although sodium fluoride (NaF) increases and alendronate (bisphosphonate, ALN) decreases bone turnover.	Sodium Fluoride	68-83	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
9165232-0	1997	High glucose enhances the gene expression of interleukin-8 in human endothelial cells, but not in smooth muscle cells: possible role of interleukin-8 in diabetic macroangiopathy.	Glucose	5-12	C-X-C motif chemokine ligand 8	Homo sapiens	45-58
9181275-4	1997	Among the serum cytokines mainly produced by monocytes/macrophages interleukin (IL)-8 levels were decreased in steroid-sensitive patients vs controls, with normal levels observed for IL-1 alpha, IL-1 beta, IL-1RA and tumor necrosis factor (TNF-alpha).	Steroids	111-118	C-X-C motif chemokine ligand 8	Homo sapiens	67-85
9165232-1	1997	We examined the effect of high glucose concentrations on the production of interleukin(IL)-8, which seems to be important for the development of atherosclerosis, in cultured human aortic endothelial cells (AoEC) and smooth muscle cells (AoSMC).	Glucose	31-38	C-X-C motif chemokine ligand 8	Homo sapiens	75-92
9165232-3	1997	After 2 days" culture, 42.5 mmol/l glucose enhanced IL-8 mRNA expression in AoEC, but not in AoSMC, compared to 4 mmol/l glucose.	Glucose	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
9179547-1	1997	Superoxide release in neutrophils and sera levels of interleukin 8 (IL-8) were determined in 15 patients with complicated acute myocardial infarction (MI) and 15 patients with uncomplicated MI.	Superoxides	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
9165232-4	1997	After 7 days" culture, the IL-8 concentration in AoEC lysate and the expression of IL-8 mRNA were significantly increased by 20.5 mmol/l glucose, or 42.5 mmol/l glucose compared to 4 mmol/l glucose.	Glucose	137-144	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
9165232-4	1997	After 7 days" culture, the IL-8 concentration in AoEC lysate and the expression of IL-8 mRNA were significantly increased by 20.5 mmol/l glucose, or 42.5 mmol/l glucose compared to 4 mmol/l glucose.	Glucose	137-144	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
9165232-4	1997	After 7 days" culture, the IL-8 concentration in AoEC lysate and the expression of IL-8 mRNA were significantly increased by 20.5 mmol/l glucose, or 42.5 mmol/l glucose compared to 4 mmol/l glucose.	Glucose	161-168	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
9165232-4	1997	After 7 days" culture, the IL-8 concentration in AoEC lysate and the expression of IL-8 mRNA were significantly increased by 20.5 mmol/l glucose, or 42.5 mmol/l glucose compared to 4 mmol/l glucose.	Glucose	161-168	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
9165232-4	1997	After 7 days" culture, the IL-8 concentration in AoEC lysate and the expression of IL-8 mRNA were significantly increased by 20.5 mmol/l glucose, or 42.5 mmol/l glucose compared to 4 mmol/l glucose.	Glucose	161-168	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
9136832-8	1997	Cycloheximide treatment resulted in superinduction of IL-8 mRNA; however, dexamethasone inhibited E. histolytica-induced IL-8 gene expression.	Cycloheximide	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
9165232-4	1997	After 7 days" culture, the IL-8 concentration in AoEC lysate and the expression of IL-8 mRNA were significantly increased by 20.5 mmol/l glucose, or 42.5 mmol/l glucose compared to 4 mmol/l glucose.	Glucose	161-168	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
9136832-8	1997	Cycloheximide treatment resulted in superinduction of IL-8 mRNA; however, dexamethasone inhibited E. histolytica-induced IL-8 gene expression.	Dexamethasone	74-87	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
9165232-5	1997	On the other hand, the IL-8 concentration in AoSMC lysate was not affected by any glucose concentration and the expression of IL-8 mRNA in AoSMC was diminished by high glucose.	Glucose	168-175	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
9165232-6	1997	These results suggest that the chemotactic gradient by IL-8 is established between arterial intima and media in response to high glucose levels in diabetic patients, and that it may be one of the key factors for SMC migration to the intima leading to diabetic macroangiopathy.	Glucose	129-136	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
9136936-4	1997	Using an immunostaining method that enables simultaneous detection of cytokines and phenotype, 56 +/- 6% CD34+ peripheral blood progenitor cells (PBPC) were found to contain cytoplasmic IL-8 after stimulation with phorbol myristate acetate + ionomycin for 90 min.	Tetradecanoylphorbol Acetate	214-239	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
9188199-0	1997	Production of human interleukin-8 expressed in Escherichia coli: from a laboratory scale for in vitro tests via a technical scale for animal studies to a process scale for a GMP-compatible production.	guanosine 5'-monophosphorothioate	174-177	C-X-C motif chemokine ligand 8	Homo sapiens	20-33
9130647-0	1997	Chemoattractant receptors for interleukin-8 and C5a: expression on peripheral blood leukocytes and differential regulation on HL-60 and AML-193 cells by vitamin D3 and all-trans retinoic acid.	Cholecalciferol	153-163	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
9130647-0	1997	Chemoattractant receptors for interleukin-8 and C5a: expression on peripheral blood leukocytes and differential regulation on HL-60 and AML-193 cells by vitamin D3 and all-trans retinoic acid.	Tretinoin	178-191	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
9161853-2	1997	We measured creatinine-collected urinary levels of IL-6 and IL-8 by an enzyme-linked immunosorbent assay in 21 women with urethritis syndrome as well as 20 age-matched healthy women.	Creatinine	12-22	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
9176105-8	1997	AcLDL stimulated IL-8 secretion &gt; TNF-alpha &gt; IL-1 alpha &gt; IL-2 = IFN-gamma = IL-1 beta, and decreased GM-CSF secretion eightfold.	acldl	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
9170624-2	1997	Radioiodination of IL-8 was catalysed by chloramine-T, and human leukocytes were radiolabelled with 111In-oxine.	chloramine-T	41-53	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
9170624-2	1997	Radioiodination of IL-8 was catalysed by chloramine-T, and human leukocytes were radiolabelled with 111In-oxine.	indium oxine	100-111	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
9096344-3	1997	We demonstrate that phosphatidylinositol-3-kinase (PI3K) activity, as determined by inhibition using wortmannin and LY294002, is required for IL-8-induced cell migration of human neutrophils.	Wortmannin	101-111	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
9155955-0	1997	Anthralin (dithranol) in vitro inhibits human monocytes to secrete IL-6, IL-8 and TNF-alpha, but not IL-1.	Anthralin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
9155955-0	1997	Anthralin (dithranol) in vitro inhibits human monocytes to secrete IL-6, IL-8 and TNF-alpha, but not IL-1.	Anthralin	11-20	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
9155955-9	1997	The results show a dose-dependent inhibition of MO IL-6, IL-8, and TNF-alpha release with a half-maximal inhibitory concentration of 0.25-0.6 microgram/ml of anthralin.	Anthralin	158-167	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
9146930-10	1997	For healthy subjects and the four patients exposed to saline, the level of IL-8 did not increase after challenge in comparison with that at baseline.	Sodium Chloride	54-60	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
9096344-3	1997	We demonstrate that phosphatidylinositol-3-kinase (PI3K) activity, as determined by inhibition using wortmannin and LY294002, is required for IL-8-induced cell migration of human neutrophils.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
9096344-5	1997	The regulation of cell migration by IL-8 is independent of ERK kinase and ERK activation since the ERK kinase inhibitor PD098059 had no effect on IL-8-induced cell migration of human neutrophils.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	120-128	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
9141135-1	1997	The characteristic CXC chemokine disulfide core of interleukin-8 (IL-8) has been rearranged in a variant replacing the 9-50 disulfide with a 9-38 disulfide.	Disulfides	33-42	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
9087177-4	1997	In contrast, exposure of PBMC to hyperosmotic conditions (330-410 mOsM) by the addition of NaCl to tissue culture medium induced gene expression for IL-1 alpha, IL-1 beta, and IL-8.	PBMC	25-29	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
9141135-1	1997	The characteristic CXC chemokine disulfide core of interleukin-8 (IL-8) has been rearranged in a variant replacing the 9-50 disulfide with a 9-38 disulfide.	Disulfides	33-42	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
9141135-1	1997	The characteristic CXC chemokine disulfide core of interleukin-8 (IL-8) has been rearranged in a variant replacing the 9-50 disulfide with a 9-38 disulfide.	9-50 disulfide	119-133	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
9141135-1	1997	The characteristic CXC chemokine disulfide core of interleukin-8 (IL-8) has been rearranged in a variant replacing the 9-50 disulfide with a 9-38 disulfide.	9-50 disulfide	119-133	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
9141135-1	1997	The characteristic CXC chemokine disulfide core of interleukin-8 (IL-8) has been rearranged in a variant replacing the 9-50 disulfide with a 9-38 disulfide.	38 disulfide	143-155	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
9141135-1	1997	The characteristic CXC chemokine disulfide core of interleukin-8 (IL-8) has been rearranged in a variant replacing the 9-50 disulfide with a 9-38 disulfide.	38 disulfide	143-155	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
9141135-5	1997	The Glu38--&gt;Cys/Cys50--&gt;Ala IL-8 crystallizes in space group P2(1)2(1)2(1) with cell parameters a = 46.4, b = 49.2, and c = 69.5 A, and has been refined to an R-value of 19.4% for data from 10 to 2 A resolution.	Cysteine	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
9141135-5	1997	The Glu38--&gt;Cys/Cys50--&gt;Ala IL-8 crystallizes in space group P2(1)2(1)2(1) with cell parameters a = 46.4, b = 49.2, and c = 69.5 A, and has been refined to an R-value of 19.4% for data from 10 to 2 A resolution.	Alanine	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
9125224-1	1997	LPS-induced expression of the IL-8 gene was markedly enhanced by H2O2 or by deprivation of the cellular antioxidant glutathione by L-buthionine-(S,R)-sulfoximine (BSO) in human astrocytoma U373 cells.	Hydrogen Peroxide	65-69	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
9125224-1	1997	LPS-induced expression of the IL-8 gene was markedly enhanced by H2O2 or by deprivation of the cellular antioxidant glutathione by L-buthionine-(S,R)-sulfoximine (BSO) in human astrocytoma U373 cells.	Glutathione	116-127	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
9125224-1	1997	LPS-induced expression of the IL-8 gene was markedly enhanced by H2O2 or by deprivation of the cellular antioxidant glutathione by L-buthionine-(S,R)-sulfoximine (BSO) in human astrocytoma U373 cells.	l-buthionine sulfoximine	131-161	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
9125224-1	1997	LPS-induced expression of the IL-8 gene was markedly enhanced by H2O2 or by deprivation of the cellular antioxidant glutathione by L-buthionine-(S,R)-sulfoximine (BSO) in human astrocytoma U373 cells.	Buthionine Sulfoximine	163-166	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
9087177-4	1997	In contrast, exposure of PBMC to hyperosmotic conditions (330-410 mOsM) by the addition of NaCl to tissue culture medium induced gene expression for IL-1 alpha, IL-1 beta, and IL-8.	Sodium Chloride	91-95	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
9125204-1	1997	Chemotactic factors, i.e., an N-formyl peptide, C5a, interleukin-8, and leukotriene B4, induced neutrophils to activate mitogen-activated protein (MAP) kinases, as defined by the tyrosine phosphorylation and decrease in electrophoretic mobility of immunodetected 44-, 42-, and 40-kDa proteins.	Tyrosine	179-187	C-X-C motif chemokine ligand 8	Homo sapiens	53-66
9084925-0	1997	Effects of long-term administration of roxithromycin on neutrophil count and interleukin-8 level in endometrial cavity subjected to pyometra.	Roxithromycin	39-52	C-X-C motif chemokine ligand 8	Homo sapiens	77-90
9124593-3	1997	TNF-alpha or PAF alone induced only approximately two- to threefold increases in membrane-bound elastase but exhibited marked dose- and time-dependent priming effects for subsequent stimulation with fMLP or IL-8 (up to 20-fold increases in membrane-bound human leukocyte elastase compared with unstimulated cells).	Platelet Activating Factor	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	207-211
9140523-3	1997	Although IL-5 alone induced little or no IL-8 production from eosinophils, short-term preincubation with IL-5 markedly enhanced the eosinophil IL-8 generation caused by C5a plus cytochalasin B (CB).	Cytochalasin B	178-192	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
9134225-13	1997	One of the following cytokines (epidermal growth factor, transforming growth factor alpha, interleukin-1 alpha, interleukin-1 beta, interleukin-6, interleukin-8) was required for 1,25(OH)2D3 to suppress clonal growth and induce cell differentiation.	25(oh)2d3	181-190	C-X-C motif chemokine ligand 8	Homo sapiens	147-160
9135521-5	1997	All chemokines inhibited IL-8 induced chemotaxis and calcium ion mobilisation by IELs, with IL-8 having the greatest effect and MCP the least.	Calcium	53-60	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
9118711-9	1997	Finally, short-term exposure to cocaine enhanced production of interleukin 8, a potent PMN chemoattractant and neutrophil-activating factor associated with both acute and chronic lung injury.	Cocaine	32-39	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
9138479-5	1997	On the other hand, PGE1 significantly increased type I collagenase activity and IL-8 production in the SDF culture supernatants and it increased IL-6 and TGF-beta(1) production in both types of fibroblasts.	Alprostadil	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
9108184-4	1997	Interleukin-8 release from alveolar macrophages correlated with the upregulated spontaneous luminol enhanced oxidative response of pulmonary phagocytes but not with the neutrophil count in BALF.	Luminol	92-99	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
9108184-6	1997	Further, a negative correlation between interleukin-8 release of alveolar macrophages and the arterial pO2 at the time of BALF could be demonstrated (r = -0.47, p &lt; 0.05).	PO-2	103-106	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
9070442-8	1997	At salt concentrations, temperatures, and pH conditions lower than physiological, the dimerization affinity of IL-8 is greatly enhanced.	Salts	3-7	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
9597442-0	1997	[Il-8 secretion by cultured epithelial cells of human nasal mucosa and its suppression by macrolide antibiotics].	macrolide antibiotics	90-111	C-X-C motif chemokine ligand 8	Homo sapiens	1-5
9597446-0	1997	[Effects of a steroid and macrolide antibiotic on IL-8 production by neutrophils].	Steroids	14-21	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
9597446-0	1997	[Effects of a steroid and macrolide antibiotic on IL-8 production by neutrophils].	Macrolides	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
9071565-4	1997	Serum nitrate levels correlated significantly with both pro-inflammatory cytokines (IL-6, IL-8, TNF-alpha) as well as anti-inflammatory cytokines (IL-10, TNFsrI, TNFsrII).	Nitrates	6-13	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
9029135-7	1997	Analysis of the IL-8-alpha 2m interaction using SDS-PAGE gels indicated that the binding was mainly noncovalent.	Sodium Dodecyl Sulfate	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
9033286-8	1997	NaF induced dose-dependent cytotoxicity (up to approximately 90% vital dye uptake and increased [3H]C20:4 release).	Tritium	97-99	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
9081687-0	1997	Macrophages isolated from human atherosclerotic plaques produce IL-8, and oxysterols may have a regulatory function for IL-8 production.	Oxysterols	74-84	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
9081687-5	1997	When monocytes and monocyte-derived macrophages, in vitro, were exposed to a series of different oxysterols, we found that all oxysterols tested had a tendency to stimulate IL-8 production but that 25-hydroxycholesterol was the most potent one.	Oxysterols	127-137	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
9081687-6	1997	This stimulation of IL-8 production was time and dose dependent and could be blocked by cycloheximide.	Cycloheximide	88-101	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
9343954-5	1997	EDTA and bestatin could block this downregulation of IL-8 receptor.	Edetic Acid	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
9040477-5	1997	RESULTS: Although DEX (10(-8) to 10(-6) M) inhibited IL-1 beta-stimulated MCP-1 and IL-8 production, it did not inhibit TNF-alpha-stimulated chemokine secretion.	Dexamethasone	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
9040477-9	1997	CONCLUSIONS: Although DEX and CSA inhibit HRPE MCP-1 and IL-8 secretion, this is dependent on whether the inducing inflammatory mediator is IL-1 beta or TNF-alpha.	Dexamethasone	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
9040478-8	1997	Smaller, but significant, increases in IL-8 and MCP-1 resulted from CM phorbol myristic acid-stimulated T-lymphocytes.	phorbol-12-myristate	71-92	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
9040477-0	1997	Dexamethasone and cyclosporin A modulation of human retinal pigment epithelial cell monocyte chemotactic protein-1 and interleukin-8.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	119-132
9179625-7	1997	Monoclonal anti-IL-8 inhibited aurothiomalate-induced stimulation of migration.	Gold Sodium Thiomalate	31-45	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
9343954-5	1997	EDTA and bestatin could block this downregulation of IL-8 receptor.	ubenimex	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
9343954-7	1997	Addition of CaCl2 accelerated and depletion of Ca2+ inhibited the downregulation of the IL-8 receptor.	Calcium Chloride	12-17	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
9020523-0	1997	The effects of cyclosporin A, dexamethasone and other immunomodulatory drugs on induced expression of IL-3, IL-4 and IL-8 mRNA in a human mast cell line.	Cyclosporine	15-28	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
9013980-11	1997	Calcium mobilization studies using melanoma growth stimulatory activity and IL-8 suggest that a sustained loss of IL-8R B may play a part in maintaining FMLP-induced IL-8R cross-desensitization.	Calcium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
9020523-0	1997	The effects of cyclosporin A, dexamethasone and other immunomodulatory drugs on induced expression of IL-3, IL-4 and IL-8 mRNA in a human mast cell line.	Dexamethasone	30-43	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
9020523-2	1997	Resting cells expressed relatively low constitutive levels of mRNA for the cytokine genes IL-3, IL-4 and IL-8, and mRNA levels for each of these cytokines were significantly enhanced after 4-h stimulation with the calcium ionophore ionomycin.	Calcium	214-221	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
9020523-3	1997	Treatment of the cells with the immunosuppressant CsA at 10(-5) M produced a significant inhibition of ionomycin-induced expression of IL-3, IL-4 and IL-8 mRNA, and at 10(-6) M produced a significant inhibition of induced expression of IL-3 and IL-8 but not IL-4.	Cyclosporine	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
9020523-3	1997	Treatment of the cells with the immunosuppressant CsA at 10(-5) M produced a significant inhibition of ionomycin-induced expression of IL-3, IL-4 and IL-8 mRNA, and at 10(-6) M produced a significant inhibition of induced expression of IL-3 and IL-8 but not IL-4.	Cyclosporine	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	245-249
9020523-3	1997	Treatment of the cells with the immunosuppressant CsA at 10(-5) M produced a significant inhibition of ionomycin-induced expression of IL-3, IL-4 and IL-8 mRNA, and at 10(-6) M produced a significant inhibition of induced expression of IL-3 and IL-8 but not IL-4.	Ionomycin	103-112	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
9020523-3	1997	Treatment of the cells with the immunosuppressant CsA at 10(-5) M produced a significant inhibition of ionomycin-induced expression of IL-3, IL-4 and IL-8 mRNA, and at 10(-6) M produced a significant inhibition of induced expression of IL-3 and IL-8 but not IL-4.	Ionomycin	103-112	C-X-C motif chemokine ligand 8	Homo sapiens	245-249
9020523-5	1997	Treatment of the cells with the corticosteroid DEX at 10(-5) M but not 10(-6) M significantly reduced the ionomycin-induced expression of IL-3 but not IL-4 or IL-8 mRNA.	Dextromethorphan	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
9361840-0	1997	Short chain fatty acids inhibit the expression of the neutrophil chemoattractant, interleukin 8, in the Caco-2 intestinal cell line.	Fatty Acids, Volatile	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	82-95
9020026-4	1997	It was suggested that epinastine might prevent the autocrine cycle for recruitment of human eosinophils by inhibiting IL-8 release from these cells.	epinastine	22-32	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
9020026-0	1997	A novel antiallergic drug epinastine inhibits IL-8 release from human eosinophils.	epinastine	26-36	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
9020026-2	1997	A novel antiallergic agent epinastine showed a dose- and time-dependent suppressive effect on IL-8, one of the chemokines for eosinophils, released from eosinophils isolated from atopic diseases.	epinastine	27-37	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
9020026-3	1997	The time-dependent accumulation of IL-8 inhibited by cycloheximide and the evaluation of the IL-8 mRNA levels by reverse transcriptase-polymerase chain reaction suggested that its action occurred in the posttranscriptional processes.	Cycloheximide	53-66	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
11885079-6	1997	The mouthrinses containing 1% xylitol and 0.1% NaF produced the same results as 1% xylitol alone on oral glucose clearance.	Xylitol	83-90	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
11885079-6	1997	The mouthrinses containing 1% xylitol and 0.1% NaF produced the same results as 1% xylitol alone on oral glucose clearance.	Glucose	105-112	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
9118186-4	1997	One group brushed with a non-fluoridated toothpaste and a second with a paste containing 1,000 ppm fluoride as NaF.	Fluorides	99-107	C-X-C motif chemokine ligand 8	Homo sapiens	111-114
9025904-6	1997	Brefeldin A (BFA), colchicine, and the HMGCoA-reductase inhibitor fluvastatin disrupted the characteristic Golgi localization of IL-8, but only BFA inhibited its secretion.	Brefeldin A	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
9025904-6	1997	Brefeldin A (BFA), colchicine, and the HMGCoA-reductase inhibitor fluvastatin disrupted the characteristic Golgi localization of IL-8, but only BFA inhibited its secretion.	Brefeldin A	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
9025904-6	1997	Brefeldin A (BFA), colchicine, and the HMGCoA-reductase inhibitor fluvastatin disrupted the characteristic Golgi localization of IL-8, but only BFA inhibited its secretion.	Colchicine	19-29	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
9025904-6	1997	Brefeldin A (BFA), colchicine, and the HMGCoA-reductase inhibitor fluvastatin disrupted the characteristic Golgi localization of IL-8, but only BFA inhibited its secretion.	Fluvastatin	66-77	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
9152510-4	1997	In addition, serum selenium levels in 20 randomly selected AIDS-free individuals (CDC I: n = 10; CDC II: n = 10) were inversely correlated with serum concentrations of interleukin-8 (IL-8) and soluble tumor necrosis factor receptors (sTNFR) types I and II.	Selenium	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	168-181
9152510-4	1997	In addition, serum selenium levels in 20 randomly selected AIDS-free individuals (CDC I: n = 10; CDC II: n = 10) were inversely correlated with serum concentrations of interleukin-8 (IL-8) and soluble tumor necrosis factor receptors (sTNFR) types I and II.	Selenium	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
9117878-9	1997	The response to histamine was measured by PC20 (changes expressed as doubling doses: DD) IL-8 levels were obtained by ELISA, and were expressed in ng/ml.	Histamine	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
9018013-6	1997	IL-8 levels in supernatants of cells stimulated with 100 U/ml of TNF-alpha for 48 h rose significantly with increasing concentrations of Et and values obtained were as follows: 4,918 +/- 244.4 pg/ml at 0 mmol/l Et, 5,335 +/- 266.2 pg/ml at 5 mmol/l Et, 8,726 +/- 873.4 pg/ml at 50 mmol/l Et and 9,134 +/- 866.0 pg/ml at 100 mmol/l Et.	Ethanol	211-213	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9067093-6	1997	SCFAs and trichostatin A, structurally unrelated compounds which both induce histone hyperacetylation, both led to a dose-dependent inhibition of IL-8 gene expression.	Fatty Acids, Volatile	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
9067093-6	1997	SCFAs and trichostatin A, structurally unrelated compounds which both induce histone hyperacetylation, both led to a dose-dependent inhibition of IL-8 gene expression.	trichostatin A	10-24	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
9038594-0	1997	Association of antral mucosal levels of interleukin 8 and reactive oxygen radicals in patients infected with Helicobacter pylori.	reactive oxygen radicals	58-82	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
9038594-6	1997	The aims of this study were to investigate if there is any association between antral mucosal levels of interleukin 8 and reactive oxygen radicals and their relationship to gastric antral inflammation.	reactive oxygen radicals	122-146	C-X-C motif chemokine ligand 8	Homo sapiens	104-117
9038594-19	1997	Interleukin 8 concentration is associated with an infiltration of neutrophils and mononuclear cells and is correlated with the production of reactive oxygen radicals in antral gastric mucosa infected with Helicobacter pylori.	reactive oxygen radicals	141-165	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
9038594-20	1997	These findings suggest that interleukin 8 may be important in attracting and activating phagocytes to release reactive oxygen radicals, thereby causing mucosal damage.	reactive oxygen radicals	110-134	C-X-C motif chemokine ligand 8	Homo sapiens	28-41
9018013-0	1997	Enhanced interleukin-8 production by cultured Chang liver cells subjected to ethanol exposure and subsequent stimulation with tumor necrosis factor-alpha.	Ethanol	77-84	C-X-C motif chemokine ligand 8	Homo sapiens	9-22
9018013-7	1997	The chemotactic activity also increased with increasing concentrations of Et and was almost completely suppressed by anti-IL-8 antibody.	Ethanol	74-76	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
9018013-6	1997	IL-8 levels in supernatants of cells stimulated with 100 U/ml of TNF-alpha for 48 h rose significantly with increasing concentrations of Et and values obtained were as follows: 4,918 +/- 244.4 pg/ml at 0 mmol/l Et, 5,335 +/- 266.2 pg/ml at 5 mmol/l Et, 8,726 +/- 873.4 pg/ml at 50 mmol/l Et and 9,134 +/- 866.0 pg/ml at 100 mmol/l Et.	Ethanol	137-139	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9238872-3	1997	2.0% Gantrez co-polymer and 0.243% NaF in a silica abrasive base.	Silicon Dioxide	44-50	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
9018013-6	1997	IL-8 levels in supernatants of cells stimulated with 100 U/ml of TNF-alpha for 48 h rose significantly with increasing concentrations of Et and values obtained were as follows: 4,918 +/- 244.4 pg/ml at 0 mmol/l Et, 5,335 +/- 266.2 pg/ml at 5 mmol/l Et, 8,726 +/- 873.4 pg/ml at 50 mmol/l Et and 9,134 +/- 866.0 pg/ml at 100 mmol/l Et.	Ethanol	211-213	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8989903-3	1997	Increase in O2(-)-producing capacity in MPD was also observed when other receptor-mediated agonists such as interleukin-8 and concanavalin A were used, but not when phorbol ester, a direct activator of protein kinase C, was used as the triggering agonist of O2- release.	Superoxides	12-14	C-X-C motif chemokine ligand 8	Homo sapiens	108-121
8989903-3	1997	Increase in O2(-)-producing capacity in MPD was also observed when other receptor-mediated agonists such as interleukin-8 and concanavalin A were used, but not when phorbol ester, a direct activator of protein kinase C, was used as the triggering agonist of O2- release.	Superoxides	258-260	C-X-C motif chemokine ligand 8	Homo sapiens	108-121
9238873-6	1997	Results subsequent to six months of product use were as follows: At six months, the stabilized stannous fluoride dentifrice was observed to produce statistically significant 17.5% reductions in gingivitis and 27.5% reductions in gingival bleeding relative to the NaF dentifrice.	Tin Fluorides	95-112	C-X-C motif chemokine ligand 8	Homo sapiens	263-266
9479645-4	1997	Notable inhibition of IL-8 secretion by human gastric cancer cells (MKN 45) was detected in the presence of sofalcone (20-100 micrograms/ml) after co-incubation with H. pylori strains.	sofalcone	108-117	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
8977191-7	1997	Furthermore, inhibition of CD28 expression mediated by one representative active oligonucleotide, GR1, resulted in a concomitant dose-dependent diminution of anti-CD3/PMA-induced cytokine (IL-2, IFN-gamma, IL-8) production.	Oligonucleotides	81-96	C-X-C motif chemokine ligand 8	Homo sapiens	206-210
9479645-5	1997	In flow cytometric analysis, adherence of H. pylori strains to MKN 45 cells was significantly inhibited by treatment with sofalcone (20-60 micrograms/ml), indicating at least one reason for the inhibition of IL-8 secretion.	sofalcone	122-131	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
9479645-6	1997	These results show that sofalcone is an effective mucosal protective agent that inhibits both production of VT and induction of IL-8 secretion.	sofalcone	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
9055206-9	1997	The disulfide bonds have been identified by peptide mapping and sequence analysis, and are in the positions predicted by homology to interleukin-8 and platelet factor 4.	Disulfides	4-13	C-X-C motif chemokine ligand 8	Homo sapiens	133-146
8985363-6	1997	Moreover, interleukin-8 (IL-8) mRNA accumulation was evident at 20 min postinfection and was induced even in the presence of cycloheximide.	Cycloheximide	125-138	C-X-C motif chemokine ligand 8	Homo sapiens	10-23
8985363-6	1997	Moreover, interleukin-8 (IL-8) mRNA accumulation was evident at 20 min postinfection and was induced even in the presence of cycloheximide.	Cycloheximide	125-138	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
8985363-7	1997	Both MAPK activation and IL-8 production were inhibited by forskolin, a potent inhibitor of Raf-1.	Colforsin	59-68	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
9604055-1	1997	To investigate whether sodium fluoride (NaF) is able to prevent bone loss in patients treated with corticosteroids (Cs), we performed a randomized double-masked, placebo-controlled trial with 44 Cs-treated patients without established osteoporosis, defined as the absence of previous peripheral fractures and vertebral deformities on radiographs.	Sodium Fluoride	23-38	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
9698935-8	1997	Furthermore, the chemotactic activity of SAL-stimulated mast cells was inhibited by antisera against IL-5 and IL-8 (interleukins).	Sodium Chloride	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
9698935-9	1997	SAL-stimulated MO were only inhibited by anti-IL-8 antibodies as well SEP-stimulated mast cells.	Sodium Chloride	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
9698935-10	1997	These results suggest that the EO migration induced by SAL may be dependent on resident mast cells and MO and mediated by LTB4, IL-5 and IL-8.	Sodium Chloride	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
9058440-12	1997	Plasma IL-6 and IL-8 levels were marginally higher before the operation and were significantly higher on POD1 in the TPN group than in the oral group.	2',3'-dialdehyde NADP	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
9459494-4	1997	Furthermore, it is shown that NiCl2 induces mRNA expression of E-selectin, intercellular adhesion molecule-1, IL-6 and IL-8 in a 1-mM concentration.	nickel chloride	30-35	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
9518388-1	1997	Using trypan blue exclusion test it has been shown that a 18 hour incubation of human erythromyeloleukosis cell line K562 together with AlF(-4) (10 mM NaF + 20 mkM AlCl3) reduced cell proliferation and survival.	tetrafluoroaluminate	136-143	C-X-C motif chemokine ligand 8	Homo sapiens	151-154
9296896-2	1997	We have examined whether the local inflammation provoked by histamine and allergen challenge of patients with atopic bronchial asthma is associated with the appearance, in vivo interleukin-B (IL-8) in bronchoalveolar lavage fluid (BAL).	Histamine	60-69	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
9296896-5	1997	There was observed increased level of IL-8 (p &lt; 0.05) after histamine and allergen challenge test.	Histamine	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
8989833-0	1997	Nitric oxide regulation of interleukin-8 gene expression.	Nitric Oxide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
8989833-2	1997	The NO synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), inhibited interleukin (IL)-8 and IL-6 production in LPS-stimulated human whole blood in a dose-dependent manner.	NG-Nitroarginine Methyl Ester	27-59	C-X-C motif chemokine ligand 8	Homo sapiens	80-98
8989833-2	1997	The NO synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), inhibited interleukin (IL)-8 and IL-6 production in LPS-stimulated human whole blood in a dose-dependent manner.	NG-Nitroarginine Methyl Ester	61-67	C-X-C motif chemokine ligand 8	Homo sapiens	80-98
8989833-3	1997	In the presence of 1 microgram/mL LPS, L-NAME blocked IL-8 release (72 +/- 4% inhibition at 20 mM (mean +/- SEM, p &lt; .05)) 24 h post-LPS without affecting cellular viability.	NG-Nitroarginine Methyl Ester	39-45	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
8989833-5	1997	L-NAME inhibition of IL-8 production was also observed at the mRNA level.	NG-Nitroarginine Methyl Ester	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
8989833-6	1997	Conversely, direct exposure of whole blood to NO with the spontaneous NO liberator DETA NONOate caused a dose-dependent stimulation of IL-8, but had no effect on IL-6 release.	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	83-95	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
8989833-7	1997	IL-8 concentrations rose from 8.3 +/- 1.9 ng/mL at 24 h to 31.7 +/- 7.6 ng/mL at 72 h with a single stimulation of 10 mM DETA NONOate.	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	121-133	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8989833-8	1997	The hydroxyl radical scavenger dimethyl sulfoxide (DMSO) prevented the DETA NONOate induction of IL-8, suggesting the participation of the hydroxyl radical in the NO-induced IL-8 production.	Hydroxyl Radical	4-20	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
8989833-8	1997	The hydroxyl radical scavenger dimethyl sulfoxide (DMSO) prevented the DETA NONOate induction of IL-8, suggesting the participation of the hydroxyl radical in the NO-induced IL-8 production.	Hydroxyl Radical	4-20	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
8989833-8	1997	The hydroxyl radical scavenger dimethyl sulfoxide (DMSO) prevented the DETA NONOate induction of IL-8, suggesting the participation of the hydroxyl radical in the NO-induced IL-8 production.	Dimethyl Sulfoxide	31-49	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
8989833-8	1997	The hydroxyl radical scavenger dimethyl sulfoxide (DMSO) prevented the DETA NONOate induction of IL-8, suggesting the participation of the hydroxyl radical in the NO-induced IL-8 production.	Dimethyl Sulfoxide	31-49	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
8989833-8	1997	The hydroxyl radical scavenger dimethyl sulfoxide (DMSO) prevented the DETA NONOate induction of IL-8, suggesting the participation of the hydroxyl radical in the NO-induced IL-8 production.	Dimethyl Sulfoxide	51-55	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
8989833-8	1997	The hydroxyl radical scavenger dimethyl sulfoxide (DMSO) prevented the DETA NONOate induction of IL-8, suggesting the participation of the hydroxyl radical in the NO-induced IL-8 production.	Dimethyl Sulfoxide	51-55	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
8989833-8	1997	The hydroxyl radical scavenger dimethyl sulfoxide (DMSO) prevented the DETA NONOate induction of IL-8, suggesting the participation of the hydroxyl radical in the NO-induced IL-8 production.	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	71-83	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
8989833-8	1997	The hydroxyl radical scavenger dimethyl sulfoxide (DMSO) prevented the DETA NONOate induction of IL-8, suggesting the participation of the hydroxyl radical in the NO-induced IL-8 production.	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	71-83	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
8989833-8	1997	The hydroxyl radical scavenger dimethyl sulfoxide (DMSO) prevented the DETA NONOate induction of IL-8, suggesting the participation of the hydroxyl radical in the NO-induced IL-8 production.	Hydroxyl Radical	139-155	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
8989833-8	1997	The hydroxyl radical scavenger dimethyl sulfoxide (DMSO) prevented the DETA NONOate induction of IL-8, suggesting the participation of the hydroxyl radical in the NO-induced IL-8 production.	Hydroxyl Radical	139-155	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
8978549-6	1996	We calculate the changes in the lower critical solution temperature (LCST) for the C8E5 micelle-salt-water mixture as a function of salt concentration for the salts NaF, NaCl, NaBr, NaI, and Na2SO4 and compare the trends seen with experiments.	Salts	96-100	C-X-C motif chemokine ligand 8	Homo sapiens	165-168
8978549-6	1996	We calculate the changes in the lower critical solution temperature (LCST) for the C8E5 micelle-salt-water mixture as a function of salt concentration for the salts NaF, NaCl, NaBr, NaI, and Na2SO4 and compare the trends seen with experiments.	Water	101-106	C-X-C motif chemokine ligand 8	Homo sapiens	165-168
8985172-3	1996	In the first part of this study, we showed that SR 140333, an NK1 tachykinin receptor antagonist, was able to inhibit strongly the SP-induced production of interleukin (IL)-6 and IL-8 in the astrocytoma cell line.	SR 140333	48-57	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
8977111-4	1996	IL-8 production in oxidized-LDL-treated cells was mediated by reactive oxygen species, as it was partially inhibited by catalase and completely inhibited by glutathione peroxidase and N-acetylcysteine (p &lt; 0.01).	Reactive Oxygen Species	62-85	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8980116-0	1996	1H NMR evidence that Glu-38 interacts with the N-terminal functional domain in interleukin-8.	Hydrogen	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
8980116-0	1996	1H NMR evidence that Glu-38 interacts with the N-terminal functional domain in interleukin-8.	Glutamic Acid	21-24	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
8980116-1	1996	In order to assess the importance of the buried Glu-38 observed in the structure of interleukin-8, an analog in which Glu-38 was replaced with Ala (E38A analog) was investigated by 1H NMR spectroscopy and neutrophil activation.	Glutamic Acid	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
8977111-4	1996	IL-8 production in oxidized-LDL-treated cells was mediated by reactive oxygen species, as it was partially inhibited by catalase and completely inhibited by glutathione peroxidase and N-acetylcysteine (p &lt; 0.01).	Acetylcysteine	184-200	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8969274-2	1996	Recent studies in our laboratory have demonstrated that asbestos fibers stimulate lung epithelial cells to produce interleukin-8 (IL-8), the major neutrophil chemoattractant in the lung.	Asbestos	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	115-128
8969274-6	1996	Asbestos fibers as well as reactive oxygen species generating systems hypoxanthine-xanthine oxidase and hydrogen peroxide stimulated DNA binding activity to the regulatory elements in the IL-8 promoter, binding sites of nuclear factor (NF)-kappaB- and NF-IL-6-like transcription factors.	Reactive Oxygen Species	27-50	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
8969274-2	1996	Recent studies in our laboratory have demonstrated that asbestos fibers stimulate lung epithelial cells to produce interleukin-8 (IL-8), the major neutrophil chemoattractant in the lung.	Asbestos	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
8969274-6	1996	Asbestos fibers as well as reactive oxygen species generating systems hypoxanthine-xanthine oxidase and hydrogen peroxide stimulated DNA binding activity to the regulatory elements in the IL-8 promoter, binding sites of nuclear factor (NF)-kappaB- and NF-IL-6-like transcription factors.	Hydrogen Peroxide	104-121	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
8969274-8	1996	IL-8 secretion was also suppressed by staurosporine, an inhibitor of protein kinase C, and by inhibitors of tyrosine kinase such as herbimycin A and genistein.	Staurosporine	38-51	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8969274-8	1996	IL-8 secretion was also suppressed by staurosporine, an inhibitor of protein kinase C, and by inhibitors of tyrosine kinase such as herbimycin A and genistein.	herbimycin	132-144	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8969274-8	1996	IL-8 secretion was also suppressed by staurosporine, an inhibitor of protein kinase C, and by inhibitors of tyrosine kinase such as herbimycin A and genistein.	Genistein	149-158	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8969274-9	1996	The suppression paralleled the effect of these inhibitors on asbestos-induced DNA binding to the NF-kappaB- and NF-IL-6-like binding sites of the IL-8 promoter.	Asbestos	61-69	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
8969274-4	1996	Membrane permeable hydroxyl scavengers inhibited asbestos induced IL-8 expression.	Hydroxyl Radical	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
8969274-10	1996	Taken together, the results suggest that asbestos-induced redox changes and phosphorylation events, mediated by staurosporine-sensitive and tyrosine kinase(s), activate nuclear proteins which recognize the NF-kappaB/NF-IL-6 binding sites of the IL-8 promoter and contribute to the regulation of IL-8 gene expression.	Asbestos	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	245-249
8969274-10	1996	Taken together, the results suggest that asbestos-induced redox changes and phosphorylation events, mediated by staurosporine-sensitive and tyrosine kinase(s), activate nuclear proteins which recognize the NF-kappaB/NF-IL-6 binding sites of the IL-8 promoter and contribute to the regulation of IL-8 gene expression.	Asbestos	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	295-299
8969274-5	1996	Using A549 cells transfected with the -546 IL-8 construct linked to a chloramphenicol acetyl transferase reporter gene, we have shown that these antioxidants directly inhibited asbestos-stimulated IL-8 promoter-dependent transcription.	Asbestos	177-185	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
8969274-10	1996	Taken together, the results suggest that asbestos-induced redox changes and phosphorylation events, mediated by staurosporine-sensitive and tyrosine kinase(s), activate nuclear proteins which recognize the NF-kappaB/NF-IL-6 binding sites of the IL-8 promoter and contribute to the regulation of IL-8 gene expression.	Staurosporine	112-125	C-X-C motif chemokine ligand 8	Homo sapiens	245-249
8969274-5	1996	Using A549 cells transfected with the -546 IL-8 construct linked to a chloramphenicol acetyl transferase reporter gene, we have shown that these antioxidants directly inhibited asbestos-stimulated IL-8 promoter-dependent transcription.	Asbestos	177-185	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
8969274-10	1996	Taken together, the results suggest that asbestos-induced redox changes and phosphorylation events, mediated by staurosporine-sensitive and tyrosine kinase(s), activate nuclear proteins which recognize the NF-kappaB/NF-IL-6 binding sites of the IL-8 promoter and contribute to the regulation of IL-8 gene expression.	Staurosporine	112-125	C-X-C motif chemokine ligand 8	Homo sapiens	295-299
9010051-4	1996	SF IL-8 levels correlated strongly with CD, lactate, glucose and the lactate to glucose ratio when both disease groups were considered together (P &lt; 0.001).	Lactic Acid	44-51	C-X-C motif chemokine ligand 8	Homo sapiens	3-7
9010051-4	1996	SF IL-8 levels correlated strongly with CD, lactate, glucose and the lactate to glucose ratio when both disease groups were considered together (P &lt; 0.001).	Glucose	53-60	C-X-C motif chemokine ligand 8	Homo sapiens	3-7
9010051-4	1996	SF IL-8 levels correlated strongly with CD, lactate, glucose and the lactate to glucose ratio when both disease groups were considered together (P &lt; 0.001).	Lactic Acid	69-76	C-X-C motif chemokine ligand 8	Homo sapiens	3-7
9010051-4	1996	SF IL-8 levels correlated strongly with CD, lactate, glucose and the lactate to glucose ratio when both disease groups were considered together (P &lt; 0.001).	Glucose	80-87	C-X-C motif chemokine ligand 8	Homo sapiens	3-7
9216201-2	1996	N-acetylcysteine, an antioxidant, decreased the TNF alpha-induced expression of intercellular adhesion molecule-1 on cultured epithelial cells from human bronchi (BEAS-2A), and inhibited IL-8 production by those cells.	Acetylcysteine	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
9027437-5	1996	METHOD: Interleukin-8 (1.2 x 10(-7) M) in the presence and absence of histamine was administered by intradermal injection.	Histamine	70-79	C-X-C motif chemokine ligand 8	Homo sapiens	8-21
9027437-8	1996	RESULTS: In the presence of histamine, IL-8 provoked a significantly greater wheal area when compared to that produced by histamine alone (P &lt; 0.001).	Histamine	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
9027437-8	1996	RESULTS: In the presence of histamine, IL-8 provoked a significantly greater wheal area when compared to that produced by histamine alone (P &lt; 0.001).	Histamine	122-131	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
9027437-9	1996	In the presence of histamine, IL-8 produced a significantly greater neutrophil infiltrate (P &lt; 0.05), however, neither lymphocyte or eosinophil infiltration was found to be increased with IL-8 challenge.	Histamine	19-28	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
9172017-0	1996	Differential regulation of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta, and IL-10 by pentoxifylline.	Pentoxifylline	84-98	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
9172017-3	1996	We investigated PTX effects on production and mRNA expression of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta and IL-10.	Pentoxifylline	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
9172017-8	1996	We also noted that the effects of PTX on IL-6, IL-8 and IL-10 production were different in WB and in PBMC culture.	Pentoxifylline	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
9030965-5	1996	In contrast, TNF, GM-CSF and IL-8 strongly primed a subpopulation of PMN which produced large amounts of H2O2 in response to fMLP, suggesting that these cytokines may play a critical role in bactericidal killing in vivo.	Hydrogen Peroxide	105-109	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
9030965-6	1996	Furthermore, we reported a decreased H2O2 production by TNF or IL-8 primed PMN in HIV-infected patients.	Hydrogen Peroxide	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
8971006-3	1996	Infection with sucrose-purified RSV (pRSV) produced a time-dependent increase in the transcriptional initiation rate of the IL-8 gene.	Sucrose	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
8971006-3	1996	Infection with sucrose-purified RSV (pRSV) produced a time-dependent increase in the transcriptional initiation rate of the IL-8 gene.	prsv	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
8947075-4	1996	At concentrations of 10-100 ppb, O3 induced maximal release of interleukin-8 (IL-8), granulocyte/macrophage colony-stimulating factor (GM-CSF), tumour necrosis factor-alpha (TNF-alpha) and sICAM-1.	Ozone	33-35	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
8896414-0	1996	Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kappa B and AP-1 transcription factors activity.	pyrrolidine dithiocarbamic acid	0-27	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
8896414-4	1996	Both PDTC and NAC inhibited, in a dose-dependent manner, the synthesis of IL-6, IL-8, and GM-CSF induced by tumor necrosis factor (TNF)-alpha or bacterial lipopolysaccharides (LPS) in human umbilical vein endothelial cells (HUVEC).	Acetylcysteine	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
9063511-8	1996	Comparison between the two dressings revealed significant changes in IL-8 and fibronectin mRNA levels after treatment with ClearSite, while only fibronectin changes were significant after treatment with SGS with respect to normal skin.	acetylcellulose	123-132	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
8990929-3	1996	Oligonucleotide TTTTCAATTCGAAGATGATT which contain the CpG motif in hexamer palindromic sequence segments in cloned DNA augmented the expression of ICAM-1 on the endothelial cells detected by FACS analysis and also augmented the gene expression of several cytokines such as interleukin-2, interleukin-6, interleukin-8 and tumor necrosis factor alpha.	Oligonucleotides	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	304-349
8909257-3	1996	Inhibition of cellular transcription with actinomycin D added at 2 hours after LPS resulted in the substantial decrease of both IL-8 and TNF-alpha mRNAs, demonstrating half-lives of 4.6 and 2.3 hours, respectively.	Dactinomycin	42-55	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
8909257-6	1996	Both IL-8 and TNF-alpha protein levels decreased when actinomycin D was added 2 hours after LPS stimulation.	Dactinomycin	54-67	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
8955503-5	1996	We also found that both lipoteichoic acid and sialic acid stimulated concentration-dependent increases in chorion cell IL-8 production.	lipoteichoic acid	24-41	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
8955503-5	1996	We also found that both lipoteichoic acid and sialic acid stimulated concentration-dependent increases in chorion cell IL-8 production.	N-Acetylneuraminic Acid	46-57	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
8955503-7	1996	Two strains of GBS tested induced concentration-dependent increases in both IL-8 and MIP-1 alpha, but both stimulated IL-8 production to a greater extent.	gbs	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
8955503-7	1996	Two strains of GBS tested induced concentration-dependent increases in both IL-8 and MIP-1 alpha, but both stimulated IL-8 production to a greater extent.	gbs	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
8912630-0	1996	Fas-mediated stimulation induces IL-8 secretion by rheumatoid arthritis synoviocytes independently of CPP32-mediated apoptosis.	ammonium ferrous sulfate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
8947075-4	1996	At concentrations of 10-100 ppb, O3 induced maximal release of interleukin-8 (IL-8), granulocyte/macrophage colony-stimulating factor (GM-CSF), tumour necrosis factor-alpha (TNF-alpha) and sICAM-1.	Ozone	33-35	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
8947075-6	1996	10(-5) M nedocromil sodium significantly attenuated the O3-induced release of both IL-8 and GM-CSF (p&lt;0.01).	Nedocromil	9-26	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
8947075-6	1996	10(-5) M nedocromil sodium significantly attenuated the O3-induced release of both IL-8 and GM-CSF (p&lt;0.01).	Ozone	56-58	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
8947075-8	1996	Similarly, the antioxidant, glutathione, at concentrations of 400-600 microM, significantly reduced the O3-induced release of IL-8 (p&lt;0.05).	Glutathione	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
8947075-8	1996	Similarly, the antioxidant, glutathione, at concentrations of 400-600 microM, significantly reduced the O3-induced release of IL-8 (p&lt;0.05).	Ozone	104-106	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
9024987-7	1996	Tepoxalin also inhibited the secretion of a NF-kappa B regulated chemokine, IL-8, a known inducer of CD11b/CD18 expression.	tepoxalin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
8910351-8	1996	Modeling of the complete salt dependence of Kapp for wild-type, K3A, and R4T gp32s in NaCl and NaF with a simple ion-exchange model suggests that substitutions within the basic Lys3-Arg4-Lys5 sequence do not strongly modulate the net displacement of cations and anions upon poly(A) complex formation by gp32.	Salts	25-29	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
9024987-8	1996	Thus the suppression of CD11b/CD18 expression by tepoxalin may involve IL-8.	tepoxalin	49-58	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
8939177-2	1996	Nedocromil sodium produced a dose-related inhibition of ozone-induced IL-8 release from human bronchial epithelial cells and also attenuated the release of granulocyte macrophage colony-stimulating factor, tumor necrosis factor-alpha, and soluble intercellular adhesion molecule 1.	Nedocromil	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
8951539-8	1996	Interleukin-8 had similar levels for CES (0.65 +/- 0.7 ng/10 cm2) and HD/HK (0.88 +/- 0.12 ng/10 cm2), whereas melanoma growth stimulatory activity was elevated in CES (2314 +/- 97 pg/10 cm2) compared with HD/HK (1071 +/- 55 pg/10 cm2).	ARAMITE	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
8961049-11	1996	The lower concentration of cefotaxime reduced the LPS-stimulated IL-8 levels.	Cefotaxime	27-37	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
8961049-12	1996	Fleroxacin (100 mg/L) enhanced basal levels of IL-8.	Fleroxacin	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
8915773-2	1996	Millimolar concentrations of NaF induced a significant accumulation of phosphatidylethanol (PEt) in Saos-2 cells but not in MG-63 and normal osteoblast-like cells.	phosphatidylethanol	71-90	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
8915773-7	1996	The ability of NaF to induce both responses was largely dependent on the presence of extracellular calcium.	Calcium	99-106	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
8915773-8	1996	The calcium ionophore A23187 reproduced the effect of NaF, and this effect was antagonized by EGTA, suggesting that PLD activation was, at least in part, a calcium-regulated event.	Calcium	4-11	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
8915773-8	1996	The calcium ionophore A23187 reproduced the effect of NaF, and this effect was antagonized by EGTA, suggesting that PLD activation was, at least in part, a calcium-regulated event.	Calcimycin	22-28	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
8915773-8	1996	The calcium ionophore A23187 reproduced the effect of NaF, and this effect was antagonized by EGTA, suggesting that PLD activation was, at least in part, a calcium-regulated event.	Egtazic Acid	94-98	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
8915773-8	1996	The calcium ionophore A23187 reproduced the effect of NaF, and this effect was antagonized by EGTA, suggesting that PLD activation was, at least in part, a calcium-regulated event.	Calcium	156-163	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
8915773-16	1996	Hence, mobilization of calcium by NaF cannot account for the enhanced PLD activation in response to PMA stimulation.	Calcium	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
8961049-10	1996	Cefotaxime (200 mg/L) significantly (P &lt; 0.05) increased the basal levels of IL-1 beta and reduced basal IL-8 concentration after 24 h of incubation.	Cefotaxime	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
8915773-20	1996	We conclude that PLD activation by NaF in Saos-2 cells includes a fluoride-sensitive G protein, increases in the levels of intracellular calcium, and Arf/RhoA redistribution to membranes.	Fluorides	66-74	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
8915773-20	1996	We conclude that PLD activation by NaF in Saos-2 cells includes a fluoride-sensitive G protein, increases in the levels of intracellular calcium, and Arf/RhoA redistribution to membranes.	Calcium	137-144	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
8915775-1	1996	Sodium fluoride (NaF) is known to stimulate osteoblastic bone formation, but little attention has been given to the possibility that NaF also affects bone resorption and the differentiation of osteoclastic progenitor cells.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
8915775-3	1996	NaF increased cellular reduction of nitroblue tetrazolium (NBT), and this effect was strongly augmented by 1,25(OH)2D3.	Nitroblue Tetrazolium	36-57	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8915775-3	1996	NaF increased cellular reduction of nitroblue tetrazolium (NBT), and this effect was strongly augmented by 1,25(OH)2D3.	Nitroblue Tetrazolium	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8915775-3	1996	NaF increased cellular reduction of nitroblue tetrazolium (NBT), and this effect was strongly augmented by 1,25(OH)2D3.	Calcitriol	107-118	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8915775-5	1996	Furthermore, NaF increased expression of CD11b and CD66b, and this stimulation was enhanced by adding 1,25(OH)2D3.	Calcitriol	102-113	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
8915775-6	1996	The sum of these changes in classical promyelocytic cellular indices suggest: (1) that NaF stimulates the early stages of HL-60 differentiation toward a granulocyte-like cell and (2) that 1,25(OH)2D3 promotes these actions of NaF.	(oh)2d3	192-199	C-X-C motif chemokine ligand 8	Homo sapiens	226-229
8915775-8	1996	NaF also increased cellular production of prostaglandin E2 (PGE2) and nitric oxide (NO) and induced expression of inducible nitric oxide synthase (iNOS); 1,25(OH)2D3 once again augmented these NaF-induced effects.	Dinoprostone	42-58	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8915775-8	1996	NaF also increased cellular production of prostaglandin E2 (PGE2) and nitric oxide (NO) and induced expression of inducible nitric oxide synthase (iNOS); 1,25(OH)2D3 once again augmented these NaF-induced effects.	Dinoprostone	60-64	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8915775-8	1996	NaF also increased cellular production of prostaglandin E2 (PGE2) and nitric oxide (NO) and induced expression of inducible nitric oxide synthase (iNOS); 1,25(OH)2D3 once again augmented these NaF-induced effects.	Nitric Oxide	70-82	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8915775-9	1996	Similarly, NaF stimulated the production of interleukin 1 alpha (IL-1 alpha), IL-6, and tumor necrosis factor-alpha, and 1,25(OH)2D3 again strongly enhanced these effects.	Calcitriol	121-132	C-X-C motif chemokine ligand 8	Homo sapiens	11-14
8915775-10	1996	Indomethacin completely blocked stimulation of NBT reduction, NO production, and iNOS expression induced by NaF plus 1,25(OH)2D3; adding exogenous PGE2 (0.1-10 ng/ml) to these indomethacin-blocked cultures dose-dependently restored NO production.	Indomethacin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	108-111
8915775-10	1996	Indomethacin completely blocked stimulation of NBT reduction, NO production, and iNOS expression induced by NaF plus 1,25(OH)2D3; adding exogenous PGE2 (0.1-10 ng/ml) to these indomethacin-blocked cultures dose-dependently restored NO production.	Nitroblue Tetrazolium	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	108-111
8915775-10	1996	Indomethacin completely blocked stimulation of NBT reduction, NO production, and iNOS expression induced by NaF plus 1,25(OH)2D3; adding exogenous PGE2 (0.1-10 ng/ml) to these indomethacin-blocked cultures dose-dependently restored NO production.	Dinoprostone	147-151	C-X-C motif chemokine ligand 8	Homo sapiens	108-111
8915775-10	1996	Indomethacin completely blocked stimulation of NBT reduction, NO production, and iNOS expression induced by NaF plus 1,25(OH)2D3; adding exogenous PGE2 (0.1-10 ng/ml) to these indomethacin-blocked cultures dose-dependently restored NO production.	Indomethacin	176-188	C-X-C motif chemokine ligand 8	Homo sapiens	108-111
8915775-11	1996	These additional findings together with the observed slow onset (24-48 h) of NaF and 1,25(OH)2D3 interaction strongly suggest that 1,25(OH)2D3 acts as a cofactor with NaF primarily through interaction with an endogenous NaF-induced cyclo-oxygenase product(s), quite possibly PGE2 itself.	Calcitriol	85-96	C-X-C motif chemokine ligand 8	Homo sapiens	167-170
8915775-11	1996	These additional findings together with the observed slow onset (24-48 h) of NaF and 1,25(OH)2D3 interaction strongly suggest that 1,25(OH)2D3 acts as a cofactor with NaF primarily through interaction with an endogenous NaF-induced cyclo-oxygenase product(s), quite possibly PGE2 itself.	Calcitriol	85-96	C-X-C motif chemokine ligand 8	Homo sapiens	167-170
8915775-11	1996	These additional findings together with the observed slow onset (24-48 h) of NaF and 1,25(OH)2D3 interaction strongly suggest that 1,25(OH)2D3 acts as a cofactor with NaF primarily through interaction with an endogenous NaF-induced cyclo-oxygenase product(s), quite possibly PGE2 itself.	Calcitriol	131-142	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
8915775-11	1996	These additional findings together with the observed slow onset (24-48 h) of NaF and 1,25(OH)2D3 interaction strongly suggest that 1,25(OH)2D3 acts as a cofactor with NaF primarily through interaction with an endogenous NaF-induced cyclo-oxygenase product(s), quite possibly PGE2 itself.	Calcitriol	131-142	C-X-C motif chemokine ligand 8	Homo sapiens	167-170
8915775-11	1996	These additional findings together with the observed slow onset (24-48 h) of NaF and 1,25(OH)2D3 interaction strongly suggest that 1,25(OH)2D3 acts as a cofactor with NaF primarily through interaction with an endogenous NaF-induced cyclo-oxygenase product(s), quite possibly PGE2 itself.	Calcitriol	131-142	C-X-C motif chemokine ligand 8	Homo sapiens	167-170
8915775-11	1996	These additional findings together with the observed slow onset (24-48 h) of NaF and 1,25(OH)2D3 interaction strongly suggest that 1,25(OH)2D3 acts as a cofactor with NaF primarily through interaction with an endogenous NaF-induced cyclo-oxygenase product(s), quite possibly PGE2 itself.	Dinoprostone	275-279	C-X-C motif chemokine ligand 8	Homo sapiens	167-170
8951539-8	1996	Interleukin-8 had similar levels for CES (0.65 +/- 0.7 ng/10 cm2) and HD/HK (0.88 +/- 0.12 ng/10 cm2), whereas melanoma growth stimulatory activity was elevated in CES (2314 +/- 97 pg/10 cm2) compared with HD/HK (1071 +/- 55 pg/10 cm2).	ARAMITE	164-167	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
8915775-11	1996	These additional findings together with the observed slow onset (24-48 h) of NaF and 1,25(OH)2D3 interaction strongly suggest that 1,25(OH)2D3 acts as a cofactor with NaF primarily through interaction with an endogenous NaF-induced cyclo-oxygenase product(s), quite possibly PGE2 itself.	Dinoprostone	275-279	C-X-C motif chemokine ligand 8	Homo sapiens	167-170
8915775-12	1996	Such a mechanism for NaF and 1,25(OH)2D3 interaction would be strongly analogous to the interaction we have recently demonstrated between 1,25(OH)2D3 and PGE1 on the differentiation of HL-60 cells.	Calcitriol	138-149	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
8951626-12	1996	The results demonstrated that a 3% KNO3/Silica/NaF mouthwash compared to a Silica/NaF control significantly reduced CDS when evaluated by tactile and thermal stimuli.	potassium nitrate	35-39	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
8915775-12	1996	Such a mechanism for NaF and 1,25(OH)2D3 interaction would be strongly analogous to the interaction we have recently demonstrated between 1,25(OH)2D3 and PGE1 on the differentiation of HL-60 cells.	Alprostadil	154-158	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
8951626-12	1996	The results demonstrated that a 3% KNO3/Silica/NaF mouthwash compared to a Silica/NaF control significantly reduced CDS when evaluated by tactile and thermal stimuli.	potassium nitrate	35-39	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
8951626-12	1996	The results demonstrated that a 3% KNO3/Silica/NaF mouthwash compared to a Silica/NaF control significantly reduced CDS when evaluated by tactile and thermal stimuli.	Silicon Dioxide	40-46	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
8951626-12	1996	The results demonstrated that a 3% KNO3/Silica/NaF mouthwash compared to a Silica/NaF control significantly reduced CDS when evaluated by tactile and thermal stimuli.	Silicon Dioxide	75-81	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
8951626-12	1996	The results demonstrated that a 3% KNO3/Silica/NaF mouthwash compared to a Silica/NaF control significantly reduced CDS when evaluated by tactile and thermal stimuli.	cds	116-119	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
8951626-12	1996	The results demonstrated that a 3% KNO3/Silica/NaF mouthwash compared to a Silica/NaF control significantly reduced CDS when evaluated by tactile and thermal stimuli.	cds	116-119	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
8951626-13	1996	A 3% KNO3/silica/NaF mouthwash would, therefore appear to have therapeutic potential to alleviate CDS.	cds	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
8810307-1	1996	The capacity of neutrophils to generate superoxide (O-2) can be enhanced by prior exposure to "priming" agents such as interleukin-8 (IL-8), melanoma growth-stimulatory activity (MGSA), and neutrophil-activating peptide (ENA-78).	Superoxides	40-50	C-X-C motif chemokine ligand 8	Homo sapiens	119-132
8906207-5	1996	Among mast-cell mediators, histamine was already known to induce a rapid and transient expression of P-selectin; we demonstrated that histamine also induced an IL-6 and IL-8 secretion by HUVEC, which was concentration-dependent and inhibited by H1 or H2 receptor antagonists.	Histamine	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
8906207-5	1996	Among mast-cell mediators, histamine was already known to induce a rapid and transient expression of P-selectin; we demonstrated that histamine also induced an IL-6 and IL-8 secretion by HUVEC, which was concentration-dependent and inhibited by H1 or H2 receptor antagonists.	Histamine	134-143	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
8974126-7	1996	Although Il-6 and TNF production were again unchanged, there was a significant reduction in IL-8 production in the glutamine-supplemented group.	Glutamine	115-124	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
8900181-7	1996	The simultaneous treatment with ATRA and TNF-alpha also resulted in changes in the composition of NF-kappaB complexes bound to the IL-8 NF-kappaB site, preventing the formation of two TNF-alpha-inducible binding activities.	Tretinoin	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
8810307-1	1996	The capacity of neutrophils to generate superoxide (O-2) can be enhanced by prior exposure to "priming" agents such as interleukin-8 (IL-8), melanoma growth-stimulatory activity (MGSA), and neutrophil-activating peptide (ENA-78).	Superoxides	40-50	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
8810307-1	1996	The capacity of neutrophils to generate superoxide (O-2) can be enhanced by prior exposure to "priming" agents such as interleukin-8 (IL-8), melanoma growth-stimulatory activity (MGSA), and neutrophil-activating peptide (ENA-78).	Superoxides	52-55	C-X-C motif chemokine ligand 8	Homo sapiens	119-132
8810307-1	1996	The capacity of neutrophils to generate superoxide (O-2) can be enhanced by prior exposure to "priming" agents such as interleukin-8 (IL-8), melanoma growth-stimulatory activity (MGSA), and neutrophil-activating peptide (ENA-78).	Superoxides	52-55	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
8943539-8	1996	Decidua IL-8 concentrations were significantly increased (P = 0.019) 6 h after mifepristone and decidual MCP-1 concentration rose (non-significant) and fell significantly (P = 0.029) between 6 and 12 h after mifepristone.	Mifepristone	79-91	C-X-C motif chemokine ligand 8	Homo sapiens	8-12
8931876-0	1996	Arsenic induces interleukin-8 expression in cultured keratinocytes.	Arsenic	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	16-29
8900430-7	1996	BH101 produced large amounts of IL-1beta, IL-6 and IL-8.	bh101	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
8941999-2	1996	The concentration of IL-8 and E-alpha 1 PI in infants with CLD was low in the first 48 h of life, but dramatically increased after 48 h. The concentration of IL-8 between 48 h of life and day 5 was significantly correlated to the fraction of inspired oxygen concentration (FiO2) within 48 h of age, but not to the mean airway pressure.	Oxygen	251-257	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
8941999-2	1996	The concentration of IL-8 and E-alpha 1 PI in infants with CLD was low in the first 48 h of life, but dramatically increased after 48 h. The concentration of IL-8 between 48 h of life and day 5 was significantly correlated to the fraction of inspired oxygen concentration (FiO2) within 48 h of age, but not to the mean airway pressure.	Oxygen	251-257	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
8941999-2	1996	The concentration of IL-8 and E-alpha 1 PI in infants with CLD was low in the first 48 h of life, but dramatically increased after 48 h. The concentration of IL-8 between 48 h of life and day 5 was significantly correlated to the fraction of inspired oxygen concentration (FiO2) within 48 h of age, but not to the mean airway pressure.	fio2	273-277	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
8941999-2	1996	The concentration of IL-8 and E-alpha 1 PI in infants with CLD was low in the first 48 h of life, but dramatically increased after 48 h. The concentration of IL-8 between 48 h of life and day 5 was significantly correlated to the fraction of inspired oxygen concentration (FiO2) within 48 h of age, but not to the mean airway pressure.	fio2	273-277	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
8980877-2	1996	For most of the chemokines (IL-8, GRO-alpha, MCP-1, MIP-1 alpha) the difference in the response of leukocytes in EDTA anticoagulated blood vs those in heparinized blood was the degree of their maximal response, with a slightly higher maximal increase in CD11b expression usually seen in cells from EDTA anticoagulated blood.	Edetic Acid	113-117	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
8903513-4	1996	We first systematically mutated, in groups of two to four, all the residues in the three intracellular loops of the IL-8 type A receptor to alanine and analyzed the mutant receptors transiently expressed in 293 cells.	Alanine	140-147	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
8903513-5	1996	Four residues in the second intracellular loop (Y136, L137, I139, V140) and one residue in the third intracellular loop (M241) were shown to be crucial for mediating calcium signaling in response to IL-8.	Calcium	166-173	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
8903513-8	1996	Mutagenesis of the residues in the first intracellular loop had only weak effects on the mobilization of calcium induced by IL-8.	Calcium	105-112	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
8964083-0	1996	Cocaine down-regulates IL-2-induced peripheral blood lymphocyte IL-8 and IFN-gamma production.	Cocaine	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
8926090-9	1996	Although heat treatment of E. chaffeensis had no effect, periodate treatment completely abolished the ability of E. chaffeensis to induce IL-1beta, IL-8, and IL-10 mRNAs.	metaperiodate	57-66	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
8971982-3	1996	With membranes exposed to exogenous labeled phosphoinositides, activation of phospholipase C with calcium, with G-proteins stimulated by GTP gamma S or NaF, or with several receptor agonists, have demonstrated that all of the components of the phosphoinositide system are retained in human brain membranes and are responsive to appropriate stimuli.	Phosphatidylinositols	44-61	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
8971982-3	1996	With membranes exposed to exogenous labeled phosphoinositides, activation of phospholipase C with calcium, with G-proteins stimulated by GTP gamma S or NaF, or with several receptor agonists, have demonstrated that all of the components of the phosphoinositide system are retained in human brain membranes and are responsive to appropriate stimuli.	Phosphatidylinositols	44-60	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
8946235-5	1996	Our results can be summarized as follows: a) Monocytes were stimulated to release inflammatory cytokines like IL-8 and MIP-1 alpha, particularly when silicone was involved; b) Both silicone and polyurethane stimulated thrombocytes thus resulting in the release of P-Selectin and PDGF-AB, although polyurethane was a stronger stimulus; c) Moderate complement activation was triggered by contact with either of the artificial surfaces.	Silicones	181-189	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
8946235-5	1996	Our results can be summarized as follows: a) Monocytes were stimulated to release inflammatory cytokines like IL-8 and MIP-1 alpha, particularly when silicone was involved; b) Both silicone and polyurethane stimulated thrombocytes thus resulting in the release of P-Selectin and PDGF-AB, although polyurethane was a stronger stimulus; c) Moderate complement activation was triggered by contact with either of the artificial surfaces.	Polyurethanes	194-206	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
8841435-4	1996	Antibodies to IL-1 alpha, IL-8, and TGF beta 1 showed intense staining in silica-injured lungs as compared to saline-instilled lungs.	Silicon Dioxide	74-80	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
8823366-0	1996	Low-energy helium-neon laser irradiation stimulates interleukin-1 alpha and interleukin-8 release from cultured human keratinocytes.	Helium	11-17	C-X-C motif chemokine ligand 8	Homo sapiens	76-89
8964083-5	1996	Cocaine abrogated the IL-2-induced production of IFN-gamma and IL-8 in a dose-responsive manner.	Cocaine	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
8964083-6	1996	Cocaine also decreased PBL IFN-gamma and IL-8 mRNA expression as determined by Northern blot and slot blot analysis.	Cocaine	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
8886427-4	1996	The combined beta 1- and beta 2-adrenoceptor agonist, isoprenaline, time- (100 nM, 2-18 h) and concentration- (1-30 nM) dependently increased IL-8 protein content in the cell culture supernatant as measured by an enzyme immunosorbent assay standardized for DNA by fluoro-colorimetry.	Isoproterenol	54-66	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
8870686-5	1996	The degree of inhibition by sarafotoxin was dependent on the type of activator; especially IL-8 activated migration was strongly inhibited.	sarafotoxin	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
8886420-14	1996	Experiments using cycloheximide demonstrated that this synergistic effect of IL-13 and IL-1 alpha on IL-8 secretion was not through de novo protein synthesis.	Cycloheximide	18-31	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
8886427-11	1996	The selective beta 2-adrenoceptor agonist salbutamol (1 microM), increased IL-8 protein similarly to isoprenaline and the cyclic AMP analogue, dibutyryl cyclic AMP (1 mM) produced a corresponding effect.	Albuterol	42-52	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
8886427-13	1996	Pretreatment with isoprenaline (100 nM) followed by TNF-alpha (20 ng ml-1) increased IL-8 additively.	Isoproterenol	18-30	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
8886427-15	1996	In conclusion, beta-adrenoceptor stimulation increased the release of the neutrophil chemoattractant, IL-8 in 16HBE cells, via an increase in intracellular cyclic AMP.	Cyclic AMP	156-166	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
8756544-11	1996	Importantly, progesterone suppressed both basal and IL-1 alpha-stimulated IL-8 expression in stromal and granulosa-lutein cell types.	Progesterone	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
8756544-13	1996	The modulation of IL-8 in these cell cultures by steroid and trophic hormones suggests that IL-8 may play an important role in the physiology of ovulation, such as timely follicular rupture and neovascularization of the corpus luteum.	Steroids	49-56	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
8756544-13	1996	The modulation of IL-8 in these cell cultures by steroid and trophic hormones suggests that IL-8 may play an important role in the physiology of ovulation, such as timely follicular rupture and neovascularization of the corpus luteum.	Steroids	49-56	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
9064318-12	1996	Treatment of epithelial cells with IL-8 antisense oligonucleotides resulted in decreased monolayer-associated PMN but did not influence PMN transmigration, suggesting that epithelial IL-8 production may serve as a recruitment signal for PMN to the basal surface of polarized epithelia.	Oligonucleotides	50-66	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
8815874-8	1996	In contrast, activation with NaF of G-proteins coupled to phospholipase C was concentration dependently inhibited by H2O2, indicating impaired G-protein function.	Hydrogen Peroxide	117-121	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
9064318-12	1996	Treatment of epithelial cells with IL-8 antisense oligonucleotides resulted in decreased monolayer-associated PMN but did not influence PMN transmigration, suggesting that epithelial IL-8 production may serve as a recruitment signal for PMN to the basal surface of polarized epithelia.	Oligonucleotides	50-66	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
8876732-4	1996	Specimen exposure to 1000-ppm NaF solution increased the 24-h fluoride release from all materials, with near pre-exposure levels reached after 2-3 days.	Fluorides	62-70	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
8702597-5	1996	We demonstrated IL-8-dependent receptor internalization by monitoring the density of surface 125I-labeled IL-8 binding sites and by immunofluorescence microscopy.	Iodine-125	93-97	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
8702597-5	1996	We demonstrated IL-8-dependent receptor internalization by monitoring the density of surface 125I-labeled IL-8 binding sites and by immunofluorescence microscopy.	Iodine-125	93-97	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
8702597-10	1996	Studies with human neutrophils pretreated with 100 nM IL-8 for 5 min revealed a positive and a negative calcium response mediated by receptors A and B, respectively.	Calcium	104-111	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
8756824-2	1996	We have investigated the profile of cellular recruitment into asthmatic airways after allergen and saline exposure and its relationship to interleukin-8 (IL-8) release.	Sodium Chloride	99-105	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
8830798-4	1996	Enzyme-linked immunoassay GHSA (500 micrograms/mL)-treated hRPE cells secreted levels of IL-8 and MCP-1 detectable within 4 h and reached 26.0 +/- 1.3 and 42.2 0.4 ng/10(6) cells/mL after 24 h, respectively.	ghsa	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
8830798-5	1996	Induction of IL-8 and MCP-1 by GHSA at concentrations ranging from 62.5 to 3,000 micrograms/mL exhibited dose-dependent kinetics.	ghsa	31-35	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
8830798-6	1996	The GHSA-induced chemokine secretion by hRPE was almost completely inhibited by actinomycin D and cycloheximide, suggesting that de novo mRNA and protein synthesis are necessary for the GHSA-induced IL-8 and MCP-1 production.	ghsa	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
8830798-6	1996	The GHSA-induced chemokine secretion by hRPE was almost completely inhibited by actinomycin D and cycloheximide, suggesting that de novo mRNA and protein synthesis are necessary for the GHSA-induced IL-8 and MCP-1 production.	Dactinomycin	80-93	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
8830798-6	1996	The GHSA-induced chemokine secretion by hRPE was almost completely inhibited by actinomycin D and cycloheximide, suggesting that de novo mRNA and protein synthesis are necessary for the GHSA-induced IL-8 and MCP-1 production.	Cycloheximide	98-111	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
8830798-6	1996	The GHSA-induced chemokine secretion by hRPE was almost completely inhibited by actinomycin D and cycloheximide, suggesting that de novo mRNA and protein synthesis are necessary for the GHSA-induced IL-8 and MCP-1 production.	ghsa	186-190	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
8830798-7	1996	Northern blot analysis of GHSA-induced hRPE IL-8 and MCP-1 mRNA expression corresponded to the time- and dose-dependent increases measured by enzyme-linked immunosorbent assay.	ghsa	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
8830798-8	1996	High concentrations of glucose (20 mM; 360 mg/dl) increased GHSA-induced hRPE IL-8 and MCP-1 secretion, whereas added insulin (0.5 ng/mL) inhibited IL-8 but not MCP-1 protein secretion and mRNA expression.	Glucose	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
8830798-8	1996	High concentrations of glucose (20 mM; 360 mg/dl) increased GHSA-induced hRPE IL-8 and MCP-1 secretion, whereas added insulin (0.5 ng/mL) inhibited IL-8 but not MCP-1 protein secretion and mRNA expression.	ghsa	60-64	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
8830798-8	1996	High concentrations of glucose (20 mM; 360 mg/dl) increased GHSA-induced hRPE IL-8 and MCP-1 secretion, whereas added insulin (0.5 ng/mL) inhibited IL-8 but not MCP-1 protein secretion and mRNA expression.	ghsa	60-64	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
21594484-0	1996	Biosynthesis of IL-8 and endothelin-1,2 by immortal simian virus 40 tsA-transformed human endothelial cells.	trichostatin A	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
8702797-1	1996	IL-8 and Gro-alpha differentially stimulate calcium influx through IL-8 receptors A and B.	Calcium	44-51	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8702797-1	1996	IL-8 and Gro-alpha differentially stimulate calcium influx through IL-8 receptors A and B.	Calcium	44-51	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
8702797-4	1996	In this study, we have evaluated the effects of IL-8 and Gro-alpha on the rate of calcium influx in human neutrophils and in 293 cells transfected with type A or type B IL-8 receptors.	Calcium	82-89	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
8765098-2	1996	Inhibition of ryanodine binding was obtained by preincubation of SR membranes with ATP + NaF .	Ryanodine	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	89-92
8765098-10	1996	Furthermore, a linear relationship was obtained between the degree of ryanodine binding inhibition and the level of phosphorylation of the 160/150-kDa proteins, as controlled by ATP or NaF concentrations.	Ryanodine	70-79	C-X-C motif chemokine ligand 8	Homo sapiens	185-188
8756824-10	1996	There was a significant correlation between neutrophil numbers and IL-8 concentrations 4 h after saline exposure.	Sodium Chloride	97-103	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
8886829-0	1996	The IL-8 production in endothelial cells is stimulated by high glucose.	Glucose	63-70	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
8770057-8	1996	Both amiloride and ribavirin inhibited IL-8 mRNA induction.	Amiloride	5-14	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
8770057-8	1996	Both amiloride and ribavirin inhibited IL-8 mRNA induction.	Ribavirin	19-28	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
8770057-12	1996	Amiloride also inhibited IL-8 release from A549 cells stimulated with IL-1 or tumor necrosis factor.	Amiloride	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
8770057-13	1996	Amiloride similarly inhibited IL-8 protein release from primary human airway epithelium infected with RSV.	Amiloride	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
8894442-7	1996	IL-3 and GM-CSF were more potent in increasing the murabutide-induced response, eliciting synergistic effects on IL-8 and IL-1Ra production, at both the mRNA accumulation and the protein release.	murabutide	51-61	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
8757810-6	1996	The major capsular polysaccharide, glucuronoxylomannan, stimulated release of tumor necrosis factor alpha, IL-1beta, and IL-8 in a dose-dependent fashion.	Polysaccharides	19-33	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
8757810-6	1996	The major capsular polysaccharide, glucuronoxylomannan, stimulated release of tumor necrosis factor alpha, IL-1beta, and IL-8 in a dose-dependent fashion.	glucuronoxylomannan	35-54	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
8877727-3	1996	This enhanced expression of IL-8 was inhibited by cycloheximide or actinomycin-D.	Cycloheximide	50-63	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
8768798-6	1996	After different cellular activation either with the Ca ionophore A23187, the tripeptide formyl-methionyl-leucyl-phenylalanine (fMLP) or sodium fluoride (NaF) coincubation of PMN with APS led to a diminished generation of LTB4.	Sodium Fluoride	136-151	C-X-C motif chemokine ligand 8	Homo sapiens	153-156
8768798-8	1996	However, cells which were preactivated with APS and subsequently washed showed an increase in leukotriene formation after stimulation with fMLP or NaF but not with the Ca ionophore.	Leukotrienes	94-105	C-X-C motif chemokine ligand 8	Homo sapiens	147-150
8877727-3	1996	This enhanced expression of IL-8 was inhibited by cycloheximide or actinomycin-D.	Dactinomycin	67-80	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
8663853-8	1996	CONCLUSIONS: Pretreatment with sheep anti-TNF-alpha Fab suppresses Jarisch-Herxheimer reactions that occur after penicillin treatment for louse-borne relapsing fever, reduces the associated increases in plasma concentrations of interleukin-6 and interleukin-8, and may be useful in other forms of sepsis.	Penicillins	113-123	C-X-C motif chemokine ligand 8	Homo sapiens	246-259
8831194-9	1996	We gave some evidences of macrolides effectiveness which these drugs inhibited IL-8 production.	Macrolides	26-36	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
8812652-6	1996	Mutagenesis studies of the amino-terminal region of IL-8 showed that a tripeptide, ELR, was essential for the interaction with Site 2.	tripeptide K-26	71-81	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
8754823-9	1996	Cellular mRNA levels of vascular endothelial growth factor and interleukin-8 (IL-8), but not those of transforming growth factor alpha, were increased after treatment with 0.5 mM H2O2.	Hydrogen Peroxide	179-183	C-X-C motif chemokine ligand 8	Homo sapiens	63-76
8754823-9	1996	Cellular mRNA levels of vascular endothelial growth factor and interleukin-8 (IL-8), but not those of transforming growth factor alpha, were increased after treatment with 0.5 mM H2O2.	Hydrogen Peroxide	179-183	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
8754823-10	1996	Coadministration of anti-IL-8 antibody inhibited tubular morphogenesis enhanced by H2O2, and IL-8 itself also enhanced the formation of tube-like structures.	Hydrogen Peroxide	83-87	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
8754823-11	1996	Treatment with antisense NF-kappaB oligonucleotide completely blocked H2O2-dependent IL-8 production by endothelial cells.	Oligonucleotides	35-50	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
8812657-2	1996	In one study, with an ELISA of higher sensitivity, mean serum IL-8 concentration was 2 &amp;plusmn; 0.2 pm.	Adenosine Monophosphate	88-91	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
8754823-11	1996	Treatment with antisense NF-kappaB oligonucleotide completely blocked H2O2-dependent IL-8 production by endothelial cells.	Hydrogen Peroxide	70-74	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
8686749-4	1996	Although retinoic-acid-treated and untreated tumor cells make the same amount of interleukin-8, the major inducer of neovascularization produced by such tumor lines, they vary in production of inhibitory activity.	Tretinoin	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
8663179-5	1996	The suppressive effect of dexamethasone on IL-1beta-induced IL-8 mRNA was not observed in the presence of cycloheximide (5 microg/ml), indicating that the dexamethasone-mediated repression of IL-8 gene expression also depends on new protein synthesis.	Dexamethasone	155-168	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
8663179-6	1996	Experiments with actinomycin D demonstrated that IL-8 mRNA is long-lived and that glucocorticoids down-regulate IL-8 gene expression mainly by decreasing the mRNA stability in normal HBMS cells.	Dactinomycin	17-30	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
8663179-9	1996	Because curcumin (20 microM), an inhibitor of c-jun/AP-1 and protein kinases, also blocked IL-1beta-stimulated IL-8 gene expression implicating c-JUN/AP-1 and protein phosphorylation in the induction of IL-8 gene expression by IL-1beta, we conclude that the regulation of IL-8 mRNA by IL-1beta is mediated via protein kinase-dependent signal transduction pathways.	Curcumin	8-16	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
8663179-9	1996	Because curcumin (20 microM), an inhibitor of c-jun/AP-1 and protein kinases, also blocked IL-1beta-stimulated IL-8 gene expression implicating c-JUN/AP-1 and protein phosphorylation in the induction of IL-8 gene expression by IL-1beta, we conclude that the regulation of IL-8 mRNA by IL-1beta is mediated via protein kinase-dependent signal transduction pathways.	Curcumin	8-16	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
8663179-9	1996	Because curcumin (20 microM), an inhibitor of c-jun/AP-1 and protein kinases, also blocked IL-1beta-stimulated IL-8 gene expression implicating c-JUN/AP-1 and protein phosphorylation in the induction of IL-8 gene expression by IL-1beta, we conclude that the regulation of IL-8 mRNA by IL-1beta is mediated via protein kinase-dependent signal transduction pathways.	Curcumin	8-16	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
8695787-0	1996	Presence of autoantibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin-associated thrombocytopenia.	Heparin	96-103	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
8695787-5	1996	Five of these nine patients with anti-IL-8 or anti-NAP-2 developed thrombosis during heparin treatment, which is not statistically different from the patients with H-PF4 antibodies.	Heparin	85-92	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
8663179-4	1996	Both synthetic and natural glucocorticoids dexamethasone (10(-7)-10(-10) M) and hydrocortisone (10(-6)-10(-8) M) inhibited IL-1beta-stimulated IL-8 mRNA expression.	Hydrocortisone	80-94	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
8663179-5	1996	The suppressive effect of dexamethasone on IL-1beta-induced IL-8 mRNA was not observed in the presence of cycloheximide (5 microg/ml), indicating that the dexamethasone-mediated repression of IL-8 gene expression also depends on new protein synthesis.	Dexamethasone	26-39	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
8663179-5	1996	The suppressive effect of dexamethasone on IL-1beta-induced IL-8 mRNA was not observed in the presence of cycloheximide (5 microg/ml), indicating that the dexamethasone-mediated repression of IL-8 gene expression also depends on new protein synthesis.	Dexamethasone	26-39	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
8663179-5	1996	The suppressive effect of dexamethasone on IL-1beta-induced IL-8 mRNA was not observed in the presence of cycloheximide (5 microg/ml), indicating that the dexamethasone-mediated repression of IL-8 gene expression also depends on new protein synthesis.	Dexamethasone	155-168	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
8712682-5	1996	TPA per se has no effect on [Ca2+]i, but potently reverses the NaF or ionomycin induced [Ca2+]i rise.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
8712682-6	1996	Also, TPA partially counteracted the acidification induced by NaF.	Tetradecanoylphorbol Acetate	6-9	C-X-C motif chemokine ligand 8	Homo sapiens	62-65
8712682-7	1996	Both NaF and ionomycin per se had no effect on cell growth but partially counteracted TPA induced growth inhibition.	Tetradecanoylphorbol Acetate	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	5-8
8920803-1	1996	Heavy metal-induced contact eczematous human skin reactions to cobalt chloride and mercuric chloride were investigated for immunoreactivity to interleukin-8 (IL-8), by using an indirect immunoperoxidase staining technique.	Metals	6-11	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
8920803-1	1996	Heavy metal-induced contact eczematous human skin reactions to cobalt chloride and mercuric chloride were investigated for immunoreactivity to interleukin-8 (IL-8), by using an indirect immunoperoxidase staining technique.	cobaltous chloride	63-78	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
8840238-5	1996	A significant correlation was observed between plasma IL-8 levels and serum bilirubin levels (r = 0.72; P &lt; 0.001).	Bilirubin	76-85	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
8841838-2	1996	We now report that pentamidine inhibited the human whole blood production of the chemotactic cytokines (chemokines) interleukin (IL)-8, growth related gene alpha (GRO alpha) and monocyte chemotactic protein-1 (MCP-1).	Pentamidine	19-30	C-X-C motif chemokine ligand 8	Homo sapiens	116-134
8841838-5	1996	Time course experiments indicated that pentamidine (10 microM) retained its ability to inhibit PHA-stimulated IL-8 production even when its addition was delayed for up to 24h after mitogen stimulation.	Pentamidine	39-50	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
8884543-0	1996	Relationship between serum 3,5,3"-triiodothyronine and serum interleukin-8, interleukin-10 or interferon gamma in patients with nonthyroidal illness.	3,5,3"-triiodothyronine	27-50	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
8796788-1	1996	The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells.	Epoprostenol	107-119	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
8796788-1	1996	The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells.	Epoprostenol	121-125	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
8796788-1	1996	The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells.	6-keto pgf1	129-140	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
8796788-1	1996	The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells.	Dinoprostone	152-168	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
8699129-8	1996	This unidirectional heterologous desensitization was observed with respect to both calcium mobilization and arachidonic acid production (i.e., prestimulation of the IL-8 receptor had no effect on subsequent stimulation by either fMLP or C5a).	Calcium	83-90	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
8699129-8	1996	This unidirectional heterologous desensitization was observed with respect to both calcium mobilization and arachidonic acid production (i.e., prestimulation of the IL-8 receptor had no effect on subsequent stimulation by either fMLP or C5a).	Arachidonic Acid	108-124	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
8639799-5	1996	By contrast, the propidium iodide (PI) staining of the DNA content showed that IL-8 could prolong the survival of resting B-CLL cells in 11 of 16 cases studied.	Propidium	17-33	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
8692878-7	1996	Superoxide production, a measure of the respiratory burst, was obtained with increasing concentrations of IL-8 with maximum effects at 25 to 50 nM, but no response was observed upon challenge with GRO alpha or NAP-2 up to 1000 nM.	Superoxides	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
8692878-8	1996	The superoxide production induced by IL-8 was inhibited by anti-IL8R1, but was not affected by anti-IL8R2.	Superoxides	4-14	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
8648135-8	1996	Release of IL-8 protein and storage of IL-4 and IL-10 proteins were enhanced by exogenous IL-5 and inhibited by a transcription inhibitor, actinomycin D.	Dactinomycin	139-152	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
8726037-0	1996	Inhibitory effect of erythromycin on interleukin 8 production by 1 alpha,25-dihydroxyvitamin D3-stimulated THP-1 cells.	Erythromycin	21-33	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
8726037-0	1996	Inhibitory effect of erythromycin on interleukin 8 production by 1 alpha,25-dihydroxyvitamin D3-stimulated THP-1 cells.	Calcitriol	65-95	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
8726037-1	1996	We have recently reported that long-term administration of erythromycin at a low dose reduced the number of neutrophils and concentrations of interleukin 8 (IL-8) in bronchoalveolar lavage fluid in patients with chronic lower respiratory tract disease.	Erythromycin	59-71	C-X-C motif chemokine ligand 8	Homo sapiens	142-155
8726037-1	1996	We have recently reported that long-term administration of erythromycin at a low dose reduced the number of neutrophils and concentrations of interleukin 8 (IL-8) in bronchoalveolar lavage fluid in patients with chronic lower respiratory tract disease.	Erythromycin	59-71	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
8726037-2	1996	To investigate the mechanism of action of erythromycin, we evaluated its effect on IL-8 production in the 1 alpha,25-dihydroxyvitamin D3-stimulated human monocytic cell line THP-1.	Erythromycin	42-54	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
8726037-3	1996	Erythromycin at a concentration of 10 micrograms/ml significantly reduced IL-8 production by THP-1 cells stimulated with lipopolysaccharide (10 ng/ml) and 1% normal human serum compared with the amount produced by untreated cells (untreated cells, 2,448 pg/ml; erythromycin-treated cells, 872 pg/ml).	Erythromycin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
8726037-4	1996	Our results suggest that erythromycin may impair IL-8 production by alveolar macrophages, ultimately reducing neutrophil accumulation in the airspace.	Erythromycin	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
11866799-4	1996	Macrolide therapy caused a significant reduction in the percentage of neutrophils, NCA and mean IL-1beta, IL-8 and LTB4 concentration in BAL fluid of the patients.	Macrolides	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
11866799-6	1996	We also evaluated the in vitro inhibitory effects of macrolides on IL---8 production by vitamin D3-induced human monocytic cell line THP-1 cells when stimulated with lipopolysaccharide and serum.	Macrolides	53-63	C-X-C motif chemokine ligand 8	Homo sapiens	67-73
11866799-6	1996	We also evaluated the in vitro inhibitory effects of macrolides on IL---8 production by vitamin D3-induced human monocytic cell line THP-1 cells when stimulated with lipopolysaccharide and serum.	Cholecalciferol	88-98	C-X-C motif chemokine ligand 8	Homo sapiens	67-73
8658945-0	1996	Evaluation of plasma IL-8 (CINC) concentration during ischemia and after reperfusion in the small intestine.	Zinc	27-31	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
8796788-1	1996	The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells.	Dinoprostone	170-174	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
8764366-2	1996	We demonstrate here that U-73122 caused a concentration-dependent (10-800 nM) inhibition of N-formyl-methionyl-leucyl-phenylalanine, tumor necrosis factor-alpha (TNF alpha), interleukin-8 and phorbol myristate acetate (PMA)-triggered PMN adhesion on fibronectin, fetal bovine serum or keyhole limpet hemocyanincoated microtiter plates.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	25-32	C-X-C motif chemokine ligand 8	Homo sapiens	174-187
8764366-4	1996	Further, U-73122 suppressed interleukin-8, N-formylmethionyl-leucyl-phenylalanine and PMA-stimulated up-regulation of the beta 2-integrin, Mac-1 (CD11b/CD18), on the PMN surface (IC50 &lt; 1.3 microM).	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	28-41
8639799-6	1996	In the remaining 5 cases, 90.6% +/- 4.39% SD of the cells after culture remained viable and IL-8 could exert a significant death protection action after pretreatment with 10(-4) mol/L hydrocortisone, which reduced the percentage of viable B-CLL cells.	Hydrocortisone	184-198	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
8636420-8	1996	It was further demonstrated that AFC and farnesol inhibited KCl and NaF-induced contractions, suggesting a complex action on Ca2+ channels and G protein-dependent pathways.	N-acetyl-S-farnesylcysteine	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
8787547-0	1996	Antioncogene P53 and mitogenic cytokine interleukin-8 aberrantly expressed in psoriatic skin are inversely regulated by the antipsoriatic drug tacrolimus (FK506).	Tacrolimus	143-153	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
8787547-0	1996	Antioncogene P53 and mitogenic cytokine interleukin-8 aberrantly expressed in psoriatic skin are inversely regulated by the antipsoriatic drug tacrolimus (FK506).	Tacrolimus	155-160	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
8787547-6	1996	After 1-3 hr, IL-8 mRNA levels were dose-dependently decreased in tacrolimus (FK506)-treated cells.	Tacrolimus	66-76	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
8787547-6	1996	After 1-3 hr, IL-8 mRNA levels were dose-dependently decreased in tacrolimus (FK506)-treated cells.	Tacrolimus	78-83	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
8787547-11	1996	Together with earlier results showing downmodulation for IL-8 receptor type A expression in cultured KC treated with FK506, these results suggest that both the mitogenic IL-8/IL-8R system and the cell cycle inhibitor p53 represent potential targets for the antipsoriatic action of the drug, whereas protooncogenes acting downstream in mitogenic signal transduction cascades are unaffected.	Tacrolimus	117-122	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
8787547-11	1996	Together with earlier results showing downmodulation for IL-8 receptor type A expression in cultured KC treated with FK506, these results suggest that both the mitogenic IL-8/IL-8R system and the cell cycle inhibitor p53 represent potential targets for the antipsoriatic action of the drug, whereas protooncogenes acting downstream in mitogenic signal transduction cascades are unaffected.	Tacrolimus	117-122	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
8636420-8	1996	It was further demonstrated that AFC and farnesol inhibited KCl and NaF-induced contractions, suggesting a complex action on Ca2+ channels and G protein-dependent pathways.	Farnesol	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
8738804-8	1996	Both proteinase 3-and elastase-mediated production of IL-8 was inhibited by cycloheximide, indicating de novo synthesis.	Cycloheximide	76-89	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
8737641-4	1996	After an oral of NaF, all plasma fluoride is diffusible.	Fluorides	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
8737641-6	1996	The area under the curve of total plasma fluoride for MFP (1540 +/- 117 mumol.min/l) doubles that of NaF (811 +/- 52 mumol.min/l p &lt; 0.001).	Fluorides	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
8737641-7	1996	On this basis, in agreement with findings previously reported for the rat, it is concluded that the bioavailability of fluoride for MFP doubles that of NaF.	Fluorides	119-127	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
8724299-4	1996	While all cytokines were markedly stimulated by IL-1 alpha), co-addition of the cyclooxygenase inhibitor indomethacin enhanced IL-8 and GMCSF levels, but caused a reduction in IL-6 expression.	Indomethacin	105-117	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
8724299-6	1996	PGE2 and illoprost (PGI2 analog) enhanced IL-8 production in stimulated cells.	Dinoprostone	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
8724299-0	1996	Prostaglandin E2 enhances interleukin 8 (IL-8) and IL-6 but inhibits GMCSF production by IL-1 stimulated human synovial fibroblasts in vitro.	Dinoprostone	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	26-39
8724299-6	1996	PGE2 and illoprost (PGI2 analog) enhanced IL-8 production in stimulated cells.	illoprost	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
8724299-0	1996	Prostaglandin E2 enhances interleukin 8 (IL-8) and IL-6 but inhibits GMCSF production by IL-1 stimulated human synovial fibroblasts in vitro.	Dinoprostone	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
8724299-6	1996	PGE2 and illoprost (PGI2 analog) enhanced IL-8 production in stimulated cells.	Epoprostenol	20-24	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
9414445-9	1996	In contrast, the pro-inflammatory action of PGE may be involved in a synergistic action with chemokines such as IL-8 and play a role in parturition.	Prostaglandins E	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
8774793-4	1996	Low oxygen levels can stimulate cellular processes, such as the production of tumor necrosis factor, interleukin (IL)-1, IL-8, and nuclear factor kappa B. Kupffer cell-mediated alterations in cocultured hepatocyte function are altered by pre-exposure to hypoxic culture conditions, whereas superoxide production, intracellular pH, and adenosine triphosphate levels are decreased by hypoxia.	Oxygen	4-10	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
8645978-5	1996	After cellular preincubation with cetirizine, the amounts of LTB4 generated from neutrophil granulocytes decreased significantly when the cells were subsequently stimulated with either fMLP or NaF, in contrast to stimulations with the Ca ionophore.	Cetirizine	34-44	C-X-C motif chemokine ligand 8	Homo sapiens	193-196
8621523-0	1996	Interleukin 8 is induced by cholesterol loading of macrophages and expressed by macrophage foam cells in human atheroma.	Cholesterol	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
8621523-8	1996	The time course of IL-8 induction paralleled that of cholesterol loading.	Cholesterol	53-64	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
8621523-12	1996	We conclude that IL-8 is induced in macrophage foam cells as a response to cholesterol loading.	Cholesterol	75-86	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
8644863-4	1996	The expression of IL-8 was tested by in situ hybridization with 35S-labeled IL-8-specific RNA probes on 38 cases of HD.	Sulfur-35	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
8605191-9	1996	Interestingly, the value of Gamma(salt) is independent of the salt used (NaCl, ChCl, or NaF) and is -1.5 +/- 0.1 for fibrinopeptide A and -2.5 +/- 0.1 for fibrinopeptide B.	Salts	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	88-91
8613691-5	1996	Treatment with hydroxyl radical scavengers such as dimethyl sulfoxide (DMSO) will decrease the production of IL-8 in stimulated human whole blood, fibroblasts, type II epithelial cells, and hepatoma cells, but not other cytokines.	Hydroxyl Radical	15-31	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
8804900-5	1996	NaOCl, NaF and APF-gel treatments caused measurable changes in intensities of the bands due to CO3(2-) and HPO4(2-); the results were found to be useful for band assignments.	co3	95-98	C-X-C motif chemokine ligand 8	Homo sapiens	7-10
8804900-5	1996	NaOCl, NaF and APF-gel treatments caused measurable changes in intensities of the bands due to CO3(2-) and HPO4(2-); the results were found to be useful for band assignments.	hpo4	107-111	C-X-C motif chemokine ligand 8	Homo sapiens	7-10
8804900-9	1996	This NaOCl-induced carbonate could be removed within 20 h in a 1000 ppm NaF solution.	Sodium Hypochlorite	5-10	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
8804900-9	1996	This NaOCl-induced carbonate could be removed within 20 h in a 1000 ppm NaF solution.	Carbonates	19-28	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
8738722-7	1996	In addition, IL-8 levels were higher in patients who died (p = 0.007), and correlated with biochemical and histological parameters, and severity of liver injury: serum aspartate aminotransferase, alanine aminotransferase, total bilirubin, prothrombin time, indocyanine green retention ratio, tumor necrosis factor-alpha and peripheral neutrophil count in patients with alcoholic hepatitis.	Bilirubin	228-237	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
8738722-7	1996	In addition, IL-8 levels were higher in patients who died (p = 0.007), and correlated with biochemical and histological parameters, and severity of liver injury: serum aspartate aminotransferase, alanine aminotransferase, total bilirubin, prothrombin time, indocyanine green retention ratio, tumor necrosis factor-alpha and peripheral neutrophil count in patients with alcoholic hepatitis.	Indocyanine Green	257-274	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
8812262-1	1996	Sodium fluoride (NaF; Cas No.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
8739170-2	1996	This comparative clinical 9-month study was designed to examine the efficacy of amine/stannous fluoride (AmF/SnF2) (Meridol) and sodium fluoride (NaF).	Amines	58-63	C-X-C motif chemokine ligand 8	Homo sapiens	146-149
8613691-5	1996	Treatment with hydroxyl radical scavengers such as dimethyl sulfoxide (DMSO) will decrease the production of IL-8 in stimulated human whole blood, fibroblasts, type II epithelial cells, and hepatoma cells, but not other cytokines.	Dimethyl Sulfoxide	51-69	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
8613691-5	1996	Treatment with hydroxyl radical scavengers such as dimethyl sulfoxide (DMSO) will decrease the production of IL-8 in stimulated human whole blood, fibroblasts, type II epithelial cells, and hepatoma cells, but not other cytokines.	Dimethyl Sulfoxide	71-75	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
8613691-7	1996	Inhibition of nitric oxide synthase will decrease production of IL-8, whereas addition of nitric oxide (NO)-generating compounds will increase production of IL-8.	Nitric Oxide	14-26	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
8613691-8	1996	The hydroxyl radical appears to be the final common pathway of cell activation for IL-8 synthesis, since DMSO will inhibit the NO-driven production of IL-8.	Hydroxyl Radical	4-20	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
8613691-8	1996	The hydroxyl radical appears to be the final common pathway of cell activation for IL-8 synthesis, since DMSO will inhibit the NO-driven production of IL-8.	Hydroxyl Radical	4-20	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
8613691-8	1996	The hydroxyl radical appears to be the final common pathway of cell activation for IL-8 synthesis, since DMSO will inhibit the NO-driven production of IL-8.	Dimethyl Sulfoxide	105-109	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
8613691-8	1996	The hydroxyl radical appears to be the final common pathway of cell activation for IL-8 synthesis, since DMSO will inhibit the NO-driven production of IL-8.	Dimethyl Sulfoxide	105-109	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
8602318-2	1996	METHODS: Eighteen placentas obtained immediately after delivery were perfused with a mixture of 125I-labeled IL-8 (IL-8*) and unlabeled IL-8 in two different concentrations.	Iodine-125	96-100	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
8606506-5	1996	At 1 min, DAG formation during normoxia was decreased by IL-8 plus fibronectin while hypoxia had no regulatory effect on control of DAG formation by any of the cytokines.	Diglycerides	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
8606506-6	1996	In contrast to early DAG formation, hypoxia significantly downregulated late DAG formation induced by buffer without fibronectin, IL-8 plus fibronectin, and IL-1 beta with or without fibronectin.	Diglycerides	77-80	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
8606506-9	1996	Thus, changes in oxygen tension can directly modulate the extent of the PMN response to stimulation by IL-8, TNF-alpha, or IL-1 beta and the G PLC-receptor pathway is particularly regulated by physiologically relevant periods of hypoxia/reoxygenation.	Oxygen	17-23	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
8809187-7	1996	In this study, we found that progesterone and a synthetic progestin, medroxyprogesterone acetate (MPA) act to enhance the action of IL-1 to increase the level of IL-8 mRNA; this action of progesterone/MPA appears to be affected principally by the stabilization of IL-8 mRNA, together with a small increase in IL-8 gene transcription.	Medroxyprogesterone Acetate	69-96	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
8809187-7	1996	In this study, we found that progesterone and a synthetic progestin, medroxyprogesterone acetate (MPA) act to enhance the action of IL-1 to increase the level of IL-8 mRNA; this action of progesterone/MPA appears to be affected principally by the stabilization of IL-8 mRNA, together with a small increase in IL-8 gene transcription.	Medroxyprogesterone Acetate	69-96	C-X-C motif chemokine ligand 8	Homo sapiens	264-268
8809187-7	1996	In this study, we found that progesterone and a synthetic progestin, medroxyprogesterone acetate (MPA) act to enhance the action of IL-1 to increase the level of IL-8 mRNA; this action of progesterone/MPA appears to be affected principally by the stabilization of IL-8 mRNA, together with a small increase in IL-8 gene transcription.	Medroxyprogesterone Acetate	69-96	C-X-C motif chemokine ligand 8	Homo sapiens	264-268
8602318-2	1996	METHODS: Eighteen placentas obtained immediately after delivery were perfused with a mixture of 125I-labeled IL-8 (IL-8*) and unlabeled IL-8 in two different concentrations.	Iodine-125	96-100	C-X-C motif chemokine ligand 8	Homo sapiens	115-120
8602318-2	1996	METHODS: Eighteen placentas obtained immediately after delivery were perfused with a mixture of 125I-labeled IL-8 (IL-8*) and unlabeled IL-8 in two different concentrations.	Iodine-125	96-100	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
8602318-9	1996	Because measurement of unlabeled IL-8 yielded negative results, the radioactivity is clearly attributable to free iodine 125, which is generated during IL radiolabeling or which disassociates from IL-8 in small amounts after radiolabeling.	Iodine	114-120	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
8602318-9	1996	Because measurement of unlabeled IL-8 yielded negative results, the radioactivity is clearly attributable to free iodine 125, which is generated during IL radiolabeling or which disassociates from IL-8 in small amounts after radiolabeling.	Iodine	114-120	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
8935186-7	1996	As 12-HETE has been shown to modulate the expression and production of various proteins, the consequence of the 12-HETE uptake on the release of GM-CSF and IL8 by HBEC was assessed.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	112-119	C-X-C motif chemokine ligand 8	Homo sapiens	156-159
8608955-6	1996	Induction of tax in JPX-9 with Cd2+ was accompanied by rapid induction of IL-8, IP-10, MIP-1alpha, MIP-1beta, 1309 and SCM-1 as determined by reverse transcription PCR.	jpx-9	20-25	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
8707887-0	1996	Proinflammatory agents, IL-8 and IL-10, upregulate inducible nitric oxide synthase expression and nitric oxide production in avian osteoclast-like cells.	Nitric Oxide	61-73	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
8640818-0	1996	Taxol-dependent transcriptional activation of IL-8 expression in a subset of human ovarian cancer.	Paclitaxel	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
8640818-4	1996	Taxol induced secretion of interleukin (IL) 8 but not IL-6, IL-1alpha, or IL-1beta in 4 of 10 samples.	Paclitaxel	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	27-45
8934801-7	1996	Symptom scores for nasal sneezing, pruritus, rhinorrhea, and nasal LTB4 levels at 6 and 8 hours and IL-8 at 3, 6, and 8 hours were generally lower in astemizole-treated patients compared to those on placebo.	Astemizole	150-160	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
8934801-10	1996	This study is the first to demonstrate an effect of astemizole during NP on IL-8 and LTB4 levels with a significant correlation of neutrophil numbers in untreated patients during the nasal late phase response.	Astemizole	52-62	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
8882622-9	1996	The non-selective PKC inhibitor, staurosporine (1-300 nM) significantly increased the production of IL-1 alpha-induced IL-8 mRNA and protein.	Staurosporine	33-46	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
8882622-10	1996	A specific PKC inhibitor, chelerythrine chloride (0.1-3 microM), also caused a small concentration-dependent increase in IL-8 mRNA and protein production.	chelerythrine	26-48	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
8608647-12	1996	Our results suggest that the relative amounts of IL-1beta and IL-1Ra or IL-8 may contribute, at least in part, to the neutrophil-mediated chronic airway inflammation in patients with chronic airway disease, and long-term erythromycin therapy may down-regulate the vigorous cycle between the cytokine network and neutrophil accumulation, with resultant reduction of neutrophil-mediated inflammatory response.	Erythromycin	221-233	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
8604023-0	1996	IL-1 beta primes IL-8-activated human neutrophils for elastase release, phospholipase D activity, and calcium flux.	Calcium	102-109	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
8675084-8	1996	Exposure to toxin A for 24 hours induced interleukin 8 production in T84 and HT29 cells.	toxin a	12-19	C-X-C motif chemokine ligand 8	Homo sapiens	41-54
8675084-10	1996	During culture (in medium only), EDTA detached colonic epithelial cells produced interleukin 8 and cell death occurred by apoptosis.	Edetic Acid	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
8675084-11	1996	Colonic disease by C difficile may be initiated by toxin A mediated induction of epithelial cell interleukin 8 production and apoptosis after cell detachment from the basement membrane.	c difficile	19-30	C-X-C motif chemokine ligand 8	Homo sapiens	97-110
8641762-5	1996	Human peripheral blood monocytes and polymorphonuclear leukocytes secreted IL-8 when cultured in the presence of CPC.	cpc	113-116	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
8617783-7	1996	The metal chelating abilities of these histidine mutants of thioredoxin were successfully utilized for convenient purifications of human interleukin-8 and -11 expressed in E. coli as soluble thioredoxin fusion proteins.	Metals	4-9	C-X-C motif chemokine ligand 8	Homo sapiens	137-158
8617783-7	1996	The metal chelating abilities of these histidine mutants of thioredoxin were successfully utilized for convenient purifications of human interleukin-8 and -11 expressed in E. coli as soluble thioredoxin fusion proteins.	Histidine	39-48	C-X-C motif chemokine ligand 8	Homo sapiens	137-158
8604023-6	1996	On the contrary, it was correlated with priming of phospholipase D activity and calcium flux activated by IL-8.	Calcium	80-87	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
8604023-1	1996	Interleukin-8 (IL-8), the prototype of the alpha (e.i., C-X-C branch) chemokine family, induced elastase release in a concentration-dependent manner (50-1000 ng/mL) in cytochalasin B-treated human polymorphonuclear leukocytes (PMNs).	Cytochalasin B	168-182	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
8604023-1	1996	Interleukin-8 (IL-8), the prototype of the alpha (e.i., C-X-C branch) chemokine family, induced elastase release in a concentration-dependent manner (50-1000 ng/mL) in cytochalasin B-treated human polymorphonuclear leukocytes (PMNs).	Cytochalasin B	168-182	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
8604023-7	1996	Preincubation of the cells with ethanol and/or La3+ inhibited IL-8-induced degranulations, suggesting that activation of phospholipase D and increase of [Ca2+]i were important for this response.	Ethanol	32-39	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
8604023-7	1996	Preincubation of the cells with ethanol and/or La3+ inhibited IL-8-induced degranulations, suggesting that activation of phospholipase D and increase of [Ca2+]i were important for this response.	lanthanum(3+)	47-51	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
8721128-8	1996	The IL-8 increased during surgery in both groups but the increase was significantly less in the PGE1 group (P &lt; 0.05).	Alprostadil	96-100	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
8832978-12	1996	CONCLUSION: Our data suggest that TNF-alpha induces expression of proinflammatory cytokines such as IL-8 and MCP-1 through generation of reactive oxygen intermediates and subsequent activation of NF-kappa B in human synovial cells, and the antioxidants may inhibit, at least in part, the activation of NF-kappa B by TNF-alpha.	reactive oxygen intermediates	137-166	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
8832978-8	1996	Prior addition of antioxidant, N-acetyl-L-cysteine (NAC) or 2-oxothiazolidine-4-carboxylate (OTC), suppressed TNF-alpha stimulated expressions of IL-8, MCP-1, and collagenase mRNA in a dose dependent manner.	2-oxothiazolidine-4-carboxylic acid	60-91	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
8721128-10	1996	We conclude that PGE1 administration suppresses TNF-alpha and IL-8 responses during pneumonectomy, but its effects on IL-6 and the postoperative status were not significant.	Alprostadil	17-21	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
8779915-3	1996	Adenosine dose dependently inhibited the release of interleukin (IL)-6 and IL-8 by stimulated human umbilical vein endothelial cells (HUVEC).	Adenosine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
8729095-8	1996	In further studies, DHA dose- and time-dependently reduced also the expression of E-selectin, Intercellular Adhesion Molecule-1, interleukin (IL)-6 and IL-8, in response to IL-1, IL-4, tumor-necrosis factor, or bacterial endotoxin.	Docosahexaenoic Acids	20-23	C-X-C motif chemokine ligand 8	Homo sapiens	152-156
8605000-2	1996	Interleukin-8 triggers several functions of neutrophils in host defense: chemotaxis, degranulation and enzyme release, and superoxide production.	Superoxides	123-133	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
8621714-1	1996	Chemical modification of the interleukin-8 Leu25 --&gt; Cys mutant.	Cysteine	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	29-42
8621714-3	1996	We have previously shown that two novel CC chemokine-like properties, namely monocyte chemoattraction and binding to CC CKR-1, are introduced into IL-8 by mutating Leu25 to the conserved tyrosine present in CC chemokines.	Tyrosine	187-195	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
8621714-8	1996	However, modification of the cysteine by addition of a fluorescent N-methyl-N-(2-N-methyl, N-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl)aminoethyl)acetamido (NBD) group lowers potency in neutrophil chemotaxis and affinity in IL-8 receptor binding assays by 2 orders of magnitude.	Cysteine	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	218-222
8621714-8	1996	However, modification of the cysteine by addition of a fluorescent N-methyl-N-(2-N-methyl, N-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl)aminoethyl)acetamido (NBD) group lowers potency in neutrophil chemotaxis and affinity in IL-8 receptor binding assays by 2 orders of magnitude.	n-methyl-n-(2-n-methyl, n-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl)aminoethyl)acetamido (nbd	67-154	C-X-C motif chemokine ligand 8	Homo sapiens	218-222
8576262-3	1996	IL-8 stimulation of its receptor on neutrophils activates Ras GTP loading and the mitogen-activated protein kinase (MAPK) pathway including Raf-1 and B-Raf.	ras gtp	58-65	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8576262-9	1996	Surprisingly, wortmannin, at low concentrations, inhibits Raf-1, B-Raf, and MAPK activation in response to IL-8 and C5a demonstrating a role for phosphatidylinositol 3-kinase in the activation of Raf kinases in G protein-coupled receptor systems in human neutrophils.	Wortmannin	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
8576262-10	1996	Furthermore, wortmannin inhibits IL-8 stimulated granule release and neutrophil adherence.	Wortmannin	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
8777274-2	1996	The release of IL-8 was significantly higher in persons with high HDL, and was correlated with HDL, and inversely correlated with triglycerides and sCD14.	Triglycerides	130-143	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
8801091-3	1996	The CSF levels of IL-8 correlated with the levels of tumor necrosis factor-alpha, leukocyte count, neutrophil count, protein level, CSF/blood glucose ratio, and the number of days patients were hospitalized.	Glucose	142-149	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
8926049-0	1996	Inhibition of leukotriene formation and IL-8 release by the paf-receptor antagonist SM-12502.	3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one	84-92	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
8926049-1	1996	We analyzed the effect of the PAF receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) on the release of leukotriene B4 and IL-8 from human leukocytes.	(+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride	54-119	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
8926049-1	1996	We analyzed the effect of the PAF receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) on the release of leukotriene B4 and IL-8 from human leukocytes.	3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one	121-129	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
8926049-4	1996	The PAF receptor antagonist led to a concentration and time dependent inhibition of LTB4 formation and IL-8 release from PMN and LMB.	leptomycin B	129-132	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
8926049-5	1996	Our data clearly indicate an inhibitory effect of the PAF receptor antagonist SM-12502 on the formation of mediators of the lipoxygenase pathway and on the release of IL-8.	3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one	78-86	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
8919301-1	1996	Chronic exposure of all-trans-retinoic acid-differentiated SH-SY5Y cells to morphine (10 mu M; 2 days) results in sensitization of adenylate cyclase as characterized by a significant increase in both PGE1 receptor-mediated as well as receptor-independent (NaF, 10 mM; forskolin, 100 mu M) stimulation of effector activity.	Tretinoin	24-43	C-X-C motif chemokine ligand 8	Homo sapiens	256-259
8822349-1	1996	Sodium fluoride (NaF), which stimulates bone formation, and bisphosphonates, which reduce bone resorption, are both used in the treatment of osteoporosis, and are binding to bone mineral.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
8822349-6	1996	The changes produced by fluoride are in the same direction as seen in bones from patients treated with NaF, albeit much smaller.	Fluorides	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
8705396-5	1996	Thus, changes in oxygen tension can directly modulate the extent of the PMN response to stimulation by IL-8, TNF-alpha, or IL-1 beta, and activation of the GPLD-pathway appears to be highly sensitive to hypoxia and hypoxia/reoxygenation.	Oxygen	17-23	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
8572786-13	1996	CONCLUSIONS: Earlier steroid administration in the immunosuppressive protocol for HTx or HLTx may be preferable to reduce the inflammatory response to cardiopulmonary bypass, as reflected by a lower production of tumor necrosis factor alpha and IL-8, and a greater release of IL-10.	Steroids	21-28	C-X-C motif chemokine ligand 8	Homo sapiens	245-249
8919301-1	1996	Chronic exposure of all-trans-retinoic acid-differentiated SH-SY5Y cells to morphine (10 mu M; 2 days) results in sensitization of adenylate cyclase as characterized by a significant increase in both PGE1 receptor-mediated as well as receptor-independent (NaF, 10 mM; forskolin, 100 mu M) stimulation of effector activity.	Morphine	76-84	C-X-C motif chemokine ligand 8	Homo sapiens	256-259
8557108-0	1996	Dansyl cadaverine regulates ligand induced endocytosis of interleukin-8 receptor in human polymorphonuclear neutrophils.	monodansylcadaverine	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	58-71
8576166-1	1996	The glucocorticoid dexamethasone inhibited the production of the rat cytokine-induced neutrophil chemoattractant CINC/gro, a counterpart of human melanoma growth-stimulating activity that belongs to the interleukin-8 (IL-8) family, in the normal rat kidney epithelial cell line NRK-52E stimulated with interleukin-1 beta (IL-1 beta), lipopolysaccharide, or tumor necrosis factor alpha.	Dexamethasone	19-32	C-X-C motif chemokine ligand 8	Homo sapiens	203-216
8576166-1	1996	The glucocorticoid dexamethasone inhibited the production of the rat cytokine-induced neutrophil chemoattractant CINC/gro, a counterpart of human melanoma growth-stimulating activity that belongs to the interleukin-8 (IL-8) family, in the normal rat kidney epithelial cell line NRK-52E stimulated with interleukin-1 beta (IL-1 beta), lipopolysaccharide, or tumor necrosis factor alpha.	Dexamethasone	19-32	C-X-C motif chemokine ligand 8	Homo sapiens	218-222
8543832-5	1996	This IL-8 gene expression was inhibited by pretreatment with 5 microM taxol, a microtubule-stabilizing agent.	Paclitaxel	70-75	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
8543831-6	1996	Treatment of TPA-stimulated Mono Mac6 cells resulted in a strong potentiation of secreted IL-1 bioactivity and expression of IL-1 alpha and IL-8 mRNA.	Tetradecanoylphorbol Acetate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
8557108-4	1996	We have found that monodansyl cadaverine (MDC) inhibited about 70% of IL-8 induced endocytosis and caused 70% and 66% inhibition of IL-8 mediated chemotaxis and respiratory burst response, respectively, in neutrophils.	monodansylcadaverine	19-40	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
8543832-6	1996	Colchicine or vinblastine, microtubule-disrupting agents, induced IL-8 gene expression, which was also inhibited by taxol treatment.	Colchicine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
8543832-6	1996	Colchicine or vinblastine, microtubule-disrupting agents, induced IL-8 gene expression, which was also inhibited by taxol treatment.	Vinblastine	14-25	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
8557108-4	1996	We have found that monodansyl cadaverine (MDC) inhibited about 70% of IL-8 induced endocytosis and caused 70% and 66% inhibition of IL-8 mediated chemotaxis and respiratory burst response, respectively, in neutrophils.	monodansylcadaverine	19-40	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
8543832-6	1996	Colchicine or vinblastine, microtubule-disrupting agents, induced IL-8 gene expression, which was also inhibited by taxol treatment.	Paclitaxel	116-121	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
8557108-4	1996	We have found that monodansyl cadaverine (MDC) inhibited about 70% of IL-8 induced endocytosis and caused 70% and 66% inhibition of IL-8 mediated chemotaxis and respiratory burst response, respectively, in neutrophils.	monodansylcadaverine	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
8557108-4	1996	We have found that monodansyl cadaverine (MDC) inhibited about 70% of IL-8 induced endocytosis and caused 70% and 66% inhibition of IL-8 mediated chemotaxis and respiratory burst response, respectively, in neutrophils.	monodansylcadaverine	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
8865864-3	1996	The aim of the present study was to examine differences in interleukin (IL)-8 expression by MC from patients with NRF and from patients with end-stage renal disease (ESRD).	Methylcholanthrene	92-94	C-X-C motif chemokine ligand 8	Homo sapiens	59-77
8567958-9	1996	149: 1153-1159), we observed that treatment with CP-105,696 inhibited the acute increase in bronchoalveolar lavage (BAL) levels of IL-6 and IL-8 by 56.9 +/- 13.2% and 46.9 +/- 14.5%, respectively, 4 h after challenge with Ascaris suum antigen (Ag).	cp-105	49-55	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
8865864-6	1996	The IL-8 background level of MC isolated from patients with NRF was significantly lower than the IL-8 background level of MC derived from patients with ESRD.	Methylcholanthrene	29-31	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
8865864-6	1996	The IL-8 background level of MC isolated from patients with NRF was significantly lower than the IL-8 background level of MC derived from patients with ESRD.	Methylcholanthrene	122-124	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
9238884-11	1996	The confidence interval calculations for both incremental DFS and DFT support the conclusion that a dentifrice containing 0.3% triclosan and 2.0% PVM/MA copolymer in a 0.331% NaF/silica (1500 ppm F) base provides a level of anticaries efficacy which is "at least as good as" that provided by a dentifrice containing 1500 NaF/silica, without those additive agents.	Triclosan	127-136	C-X-C motif chemokine ligand 8	Homo sapiens	175-178
8838968-5	1996	The effect of urinary trypsin inhibitor on the production of prostaglandin E2 (PGE2) from myometrial cultures stimulated by IL-8, IL-1 and LPS was verified.	Dinoprostone	61-77	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
8838968-5	1996	The effect of urinary trypsin inhibitor on the production of prostaglandin E2 (PGE2) from myometrial cultures stimulated by IL-8, IL-1 and LPS was verified.	Dinoprostone	79-83	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
8568122-2	1996	IL-8 inhibits MCAF-induced histamine release from basophils.	Histamine	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8931954-7	1996	Following 4 days of maturation with ATRA, the cells would increase F-actin content in response to interleukin-8, ingest latex beads, migrate in a chemotaxis chamber, reduce NBT, and express CD11b.	Tretinoin	36-40	C-X-C motif chemokine ligand 8	Homo sapiens	98-111
8720280-5	1996	Alveolar macrophages cultured in vitro from the asbestos-exposed individuals spontaneously released significant amounts of the neutrophil chemotaxin, interleukin-8 (IL-8).	Asbestos	48-56	C-X-C motif chemokine ligand 8	Homo sapiens	150-163
8720280-5	1996	Alveolar macrophages cultured in vitro from the asbestos-exposed individuals spontaneously released significant amounts of the neutrophil chemotaxin, interleukin-8 (IL-8).	Asbestos	48-56	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
8720280-7	1996	In vitro experiments confirmed that crocidolite or chrysotile asbestos could stimulate the release of IL-8 from mononuclear phagocytes in a dose-dependent fashion.	Asbestos, Crocidolite	36-47	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
9238883-11	1996	The confidence interval calculations for both incremental DFS and DFT support the conclusion that a dentifrice containing 0.3% triclosan and 2.0% PVM/MA copolymer in a 0.243% NaF/silica (1100 ppm F) base provides a level of anticaries efficacy which is "at least as good as" that provided by a dentifrice containing 1100 NaF/silica without those additive agents.	Triclosan	127-136	C-X-C motif chemokine ligand 8	Homo sapiens	175-178
9238883-11	1996	The confidence interval calculations for both incremental DFS and DFT support the conclusion that a dentifrice containing 0.3% triclosan and 2.0% PVM/MA copolymer in a 0.243% NaF/silica (1100 ppm F) base provides a level of anticaries efficacy which is "at least as good as" that provided by a dentifrice containing 1100 NaF/silica without those additive agents.	copolymer	153-162	C-X-C motif chemokine ligand 8	Homo sapiens	175-178
9238884-11	1996	The confidence interval calculations for both incremental DFS and DFT support the conclusion that a dentifrice containing 0.3% triclosan and 2.0% PVM/MA copolymer in a 0.331% NaF/silica (1500 ppm F) base provides a level of anticaries efficacy which is "at least as good as" that provided by a dentifrice containing 1500 NaF/silica, without those additive agents.	copolymer	153-162	C-X-C motif chemokine ligand 8	Homo sapiens	175-178
8558067-10	1996	Mutations of one of the residues in this region, Leu-25 in IL-8, to tyrosine (which is conserved at this position in CC chemokines) enables the mutant IL-8 to bind CC chemokine receptor-1 (CC-CKR-1) and introduces monocyte chemoattractant activity.	Leucine	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
8942140-8	1996	Furthermore, the levels of interleukin-8 and neutrophil chemotactic activity in the bronchoalveolar lavage fluid of cryptogenic organizing pneumonia patients with bronchoalveolar lavage fluid neutrophilia were significantly decreased following treatment with erythromycin.	Erythromycin	259-271	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
8558067-10	1996	Mutations of one of the residues in this region, Leu-25 in IL-8, to tyrosine (which is conserved at this position in CC chemokines) enables the mutant IL-8 to bind CC chemokine receptor-1 (CC-CKR-1) and introduces monocyte chemoattractant activity.	Leucine	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
8558067-10	1996	Mutations of one of the residues in this region, Leu-25 in IL-8, to tyrosine (which is conserved at this position in CC chemokines) enables the mutant IL-8 to bind CC chemokine receptor-1 (CC-CKR-1) and introduces monocyte chemoattractant activity.	Tyrosine	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
8558067-10	1996	Mutations of one of the residues in this region, Leu-25 in IL-8, to tyrosine (which is conserved at this position in CC chemokines) enables the mutant IL-8 to bind CC chemokine receptor-1 (CC-CKR-1) and introduces monocyte chemoattractant activity.	Tyrosine	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
8722494-11	1996	MK-886 also inhibited synovial production of two other pleiotrophic cytokines which it regulates, IL-6 and IL-8.	MK-886	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
8942140-10	1996	It is possible that cryptogenic organizing pneumonia is caused by neutrophil-mediated inflammation, and that the favorable clinical effect of erythromycin is due to inhibition of neutrophil accumulation in the peripheral airways through a biological activity other than bacteriostasis, e.g., local suppression of interleukin-8 production.	Erythromycin	142-154	C-X-C motif chemokine ligand 8	Homo sapiens	313-326
8734298-11	1996	In particular, TNF and IL-8 plasma levels as well as LPS-induced monocytic production of these cytokines ex vivo have been correlated with the production of ROS by stimulated PMN and with the lung injury score in patients with Adult Respiratory Distress Syndrom (ARDS).	Reactive Oxygen Species	157-160	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
8747002-0	1996	Modulation of IL-1 beta, IL-6, IL-8, TNF-alpha, and TGF-beta secretions by alveolar macrophages under NO2 exposure.	Nitrogen Dioxide	102-105	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
8747002-7	1996	Exposure for 30 min to NO2 induced a significant decrease of LPS-stimulated IL-1 Beta, IL-6, IL-8, and TNF-alpha (p &lt; .05).	Nitrogen Dioxide	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
8747002-10	1996	NO2 exposure of LPS-stimulated AM resulted in a functional impairment of AM after NO2 exposure regarding IL-1 beta, IL-6, IL-8, and TNF-alpha.	Nitrogen Dioxide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
8883016-14	1996	In addition, the higher release of IL-1 beta and IL-8 by PMO isolated from G-PDF suggests a stronger intra-abdominal activation of PMO, with G-PDF acting as a chemical inflammatory agent.	g-pdf	75-80	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
8734298-8	1996	TNF, GM-CSF and IL-8 strongly primed a subpopulation of PMN to produce H2O2 in response to fMLP, while IL-1 alpha, IL-1 beta and IL-6 failed to do so.	Hydrogen Peroxide	71-75	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
8734298-9	1996	Furthermore, the addition of TNF, GM-CSF or IL-8 to whole blood increased the capacity of a subpopulation of PMN to bind N-formyl peptides, a phenomenon that could account for the strong H2O2 production in response to fMLP following priming by the cytokines.	n-formyl peptides	121-138	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
8734298-9	1996	Furthermore, the addition of TNF, GM-CSF or IL-8 to whole blood increased the capacity of a subpopulation of PMN to bind N-formyl peptides, a phenomenon that could account for the strong H2O2 production in response to fMLP following priming by the cytokines.	Hydrogen Peroxide	187-191	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
8734298-13	1996	In particular, in HIV infected patients we demonstrated a decrease of H2O2 production by PMN in whole blood after ex vivo priming by IL-8 and TNF followed by fMLP stimulation.	Hydrogen Peroxide	70-74	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
8833992-0	1996	Interleukin 1 beta, tumor necrosis factor alpha, and interleukin 8 in bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis: a potential mechanism of macrolide therapy.	Macrolides	167-176	C-X-C motif chemokine ligand 8	Homo sapiens	53-66
8833992-8	1996	In addition, the concentration of IL-8 in alveolar macrophages obtained from 2 volunteers before and after oral erythromycin administration also decreased ex vivo.	Erythromycin	112-124	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
8618875-3	1995	Maximal IL-8 production was seen when 40 mM salt was added (375 mosM) and was equal to IL-8 induced by endotoxin or IL-1 alpha.	Salts	44-48	C-X-C motif chemokine ligand 8	Homo sapiens	8-12
8618875-5	1995	Hyperosmolar NaCl also induced IL-8 and increased steady-state levels of IL-8 mRNA similar to those induced by IL-1 alpha.	Sodium Chloride	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
8618875-5	1995	Hyperosmolar NaCl also induced IL-8 and increased steady-state levels of IL-8 mRNA similar to those induced by IL-1 alpha.	Sodium Chloride	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
8618875-6	1995	IL-8 gene expression was elevated for 96 hr in peripheral blood mononuclear cells incubated with hyperosmolar NaCl.	Sodium Chloride	110-114	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8618875-7	1995	In human THP-1 macrophagic cells, osmotic stimulation with KI, NaI, or NaCl also induced IL-8 production.	KS I	59-61	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
8618875-7	1995	In human THP-1 macrophagic cells, osmotic stimulation with KI, NaI, or NaCl also induced IL-8 production.	Sodium Iodide	63-66	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
8618875-7	1995	In human THP-1 macrophagic cells, osmotic stimulation with KI, NaI, or NaCl also induced IL-8 production.	Sodium Chloride	71-75	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
8618875-9	1995	Using specific blockade of this kinase, a dose-response inhibition of hyperosmolar NaCl-induced IL-8 synthesis was observed, similar to that in cells stimulated with IL-1.	Sodium Chloride	83-87	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
8647994-4	1995	NHKs secreted detectable levels of IL-8, but not of IL-6, and IL-8 secretion increased over 20 fold by stimulation with 10 nM of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	129-160	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
8526925-1	1995	Fluoride (NaF) (5-15 mM) activated the 22Na+ uptake by human red blood cells (RBC).	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	10-13
8526925-4	1995	The NaF-induced 22Na+ uptake was sensitive to tetrodotoxin (TTX), pertussis toxin but not to amiloride nor valinomycin.	Tetrodotoxin	46-58	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
8526925-4	1995	The NaF-induced 22Na+ uptake was sensitive to tetrodotoxin (TTX), pertussis toxin but not to amiloride nor valinomycin.	Tetrodotoxin	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
8526925-4	1995	The NaF-induced 22Na+ uptake was sensitive to tetrodotoxin (TTX), pertussis toxin but not to amiloride nor valinomycin.	Amiloride	93-102	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
8526925-6	1995	Thus, the TTX-sensitive Na(+)-transport system is present in the RBC membrane in an inactive form which could be activated with NaF by a mechanism involving G-protein(s) but not the depolarization.	Tetrodotoxin	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	128-131
8723018-10	1995	Basal adenylyl cyclase activity increased from 33.1 +/- 2.6 40 +/- 2.4 pmol/mg protein per min; a significant increase in activity stimulated by isoproterenol (from 41.5 +/- 3.1 to 61 +/- 3.8 pmol/mg protein per min) and by NaF (from 71.8 +/- 2.7 to 85.3 +/- 3.5 pmol/mg protein per min) was also observed.	Isoproterenol	145-158	C-X-C motif chemokine ligand 8	Homo sapiens	224-227
8647994-4	1995	NHKs secreted detectable levels of IL-8, but not of IL-6, and IL-8 secretion increased over 20 fold by stimulation with 10 nM of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	129-160	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
8647994-4	1995	NHKs secreted detectable levels of IL-8, but not of IL-6, and IL-8 secretion increased over 20 fold by stimulation with 10 nM of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	162-165	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
8647994-4	1995	NHKs secreted detectable levels of IL-8, but not of IL-6, and IL-8 secretion increased over 20 fold by stimulation with 10 nM of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	162-165	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
8595612-10	1995	Up-regulation of CD11b, down-regulation of L-s and release of IL8 were inversely related to heparin concentration (r = 0.87, P &lt; 0.05).	Heparin	92-99	C-X-C motif chemokine ligand 8	Homo sapiens	62-65
8587236-0	1995	Interleukin-1-induced IL-8 and IL-6 gene expression and production in human mesangial cells is differentially regulated by cAMP.	Cyclic AMP	123-127	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
8587236-2	1995	The objective of this study was to investigate the role of cAMP in the regulation of IL-6 and IL-8 gene expression and peptide production in IL-1 stimulated human MC.	Cyclic AMP	59-63	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
8587236-9	1995	Taken together, our results demonstrate that cAMP differentially regulates IL-6 and IL-8 production in IL-1-stimulated human MC.	Cyclic AMP	45-49	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
9053741-3	1995	Trifluoperazine, N-(6-aminohexyl)-5-chloro-1- naphthalenesulphonamide (W-7), fendiline and calmidazolium themselves had no effect on basal IP formation, but concentration-dependently (1-30 microM) potentiated ATP-, NaF- and A23187-stimulated IP formation.	n-(6-aminohexyl)-5-chloro-1- naphthalenesulphonamide	17-69	C-X-C motif chemokine ligand 8	Homo sapiens	215-218
7497463-3	1995	In this paper, data are summarized revealing the ability of WBH to induce elevated plasma levels of granulocyte-colony stimulating factor (G-CSF), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-alpha) within hours of WBH.	wbh	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	201-214
7497463-3	1995	In this paper, data are summarized revealing the ability of WBH to induce elevated plasma levels of granulocyte-colony stimulating factor (G-CSF), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-alpha) within hours of WBH.	wbh	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	216-220
8595612-3	1995	DESIGN: In a series of experiments, we examined the effect of heparin (4 U/ml) comparing it with ethylenediamine tetra-acetate (EDTA, 1.5 mg/ml) and citrate mixture (100 microliters/ml), heparin dose-response, IL8 (human recombinant IL8) dose-response and protamine (80 micrograms/ml) neutralisation of heparin (4 U/ml) using donor blood (total of 38).	Heparin	62-69	C-X-C motif chemokine ligand 8	Homo sapiens	210-213
8595612-3	1995	DESIGN: In a series of experiments, we examined the effect of heparin (4 U/ml) comparing it with ethylenediamine tetra-acetate (EDTA, 1.5 mg/ml) and citrate mixture (100 microliters/ml), heparin dose-response, IL8 (human recombinant IL8) dose-response and protamine (80 micrograms/ml) neutralisation of heparin (4 U/ml) using donor blood (total of 38).	Heparin	62-69	C-X-C motif chemokine ligand 8	Homo sapiens	233-236
7592725-8	1995	Thus, phosphatidic acid and lysophosphatidic acid, similarly to other physiological chemoattractants (e.g. C5a and interleukin-8), induce cell migration by an haptotactic mechanism.	Phosphatidic Acids	6-23	C-X-C motif chemokine ligand 8	Homo sapiens	115-128
7580291-3	1995	Histamine, but not PAF or endothelin-1, showed a dose-dependent stimulatory effect on the release of interleukin-6, interleukin-8 and granulocyte-macrophage colony-stimulating factor by normal and transformed human bronchial epithelial cells when studied 6 h after the treatment.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	116-129
7499684-6	1995	Allergen challenge after exposure to both air and NO2 significantly (p &lt; 0.05) increased levels of MCT, but not MPO and IL-8 in the nasal lavage fluid.	Nitrogen Dioxide	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
7594569-7	1995	The experiments presented here demonstrate that Fas Ag ligation alone led to production of IL-8 by colonic epithelial cells and represented another function mediated by Fas Ag in addition to apoptosis.	ammonium ferrous sulfate	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
7578017-2	1995	This receptor (ET-IL-8RA) displayed functional properties similar to those of the native receptor in neutrophils in that exposure to IL-8 stimulated GTPase activity, phosphoinositide (PI) hydrolysis, intracellular calcium mobilization, and degranulation in a pertussis toxin (PTx) susceptible fashion.	Calcium	214-221	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
7578017-5	1995	Staurosporine totally blocked PMA-induced phosphorylation but only partially inhibited IL-8-mediated phosphorylation.	Staurosporine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
7586450-3	1995	We hypothesized that human endothelial cells deprived of oxygen would secrete IL-8, which might translate into elevated IL-8 production after cardiac ischemia.	Oxygen	57-63	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
7586450-3	1995	We hypothesized that human endothelial cells deprived of oxygen would secrete IL-8, which might translate into elevated IL-8 production after cardiac ischemia.	Oxygen	57-63	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
7592725-8	1995	Thus, phosphatidic acid and lysophosphatidic acid, similarly to other physiological chemoattractants (e.g. C5a and interleukin-8), induce cell migration by an haptotactic mechanism.	lysophosphatidic acid	28-49	C-X-C motif chemokine ligand 8	Homo sapiens	115-128
7559482-9	1995	Examination of additional IL-8-based mutants in the colony formation assay, which centered on the perturbation of the amino-terminal "ELR" motif, resulted in the observation that the highly active IL-8 mutant required both aspartic acid at amino acid residue 4 and either glutamine or asparagine at residue 6.	Aspartic Acid	223-236	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
7559482-9	1995	Examination of additional IL-8-based mutants in the colony formation assay, which centered on the perturbation of the amino-terminal "ELR" motif, resulted in the observation that the highly active IL-8 mutant required both aspartic acid at amino acid residue 4 and either glutamine or asparagine at residue 6.	Glutamine	272-281	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
7559482-9	1995	Examination of additional IL-8-based mutants in the colony formation assay, which centered on the perturbation of the amino-terminal "ELR" motif, resulted in the observation that the highly active IL-8 mutant required both aspartic acid at amino acid residue 4 and either glutamine or asparagine at residue 6.	Asparagine	285-295	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
7670094-4	1995	Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA).	Calcitriol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
8634157-1	1995	PURPOSE: To evaluate the efficacy of a sodium fluoride (NaF)/silica/xylitol dentifrice compared with that of a positive control NaF/silica dentifrice on caries increments in school children over a 3-year period in an area without an optimal level of fluoride in the drinking water (mean level &lt;0.1 ppm).	Sodium Fluoride	39-54	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
8634157-1	1995	PURPOSE: To evaluate the efficacy of a sodium fluoride (NaF)/silica/xylitol dentifrice compared with that of a positive control NaF/silica dentifrice on caries increments in school children over a 3-year period in an area without an optimal level of fluoride in the drinking water (mean level &lt;0.1 ppm).	Fluorides	46-54	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
7575485-9	1995	Calyculin A also acted synergistically with IL-1 or TNF alpha to cause a 2-fold potentiation of IL-1- or TNF alpha-induced IL-8 mRNA and peptide and RANTES mRNA expression.	calyculin A	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
7670094-4	1995	Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA).	Phorbol Esters	169-182	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
7670094-4	1995	Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA).	Phorbol Esters	169-182	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
7670094-4	1995	Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA).	Tetradecanoylphorbol Acetate	184-187	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
7670094-8	1995	Calcitriol does not alter the expression of any of these mRNAs, and only the stimulation of IL-8 mRNA by sodium butyrate is recovered.	Butyric Acid	105-120	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
7670094-4	1995	Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA).	Calcitriol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
7670094-4	1995	Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA).	Calcitriol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
7670094-4	1995	Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA).	Tretinoin	18-20	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
7670094-4	1995	Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA).	Tretinoin	18-20	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
8593446-0	1995	Effect of theophylline on the production of interleukin-1 beta, tumor necrosis factor-alpha, and interleukin-8 by human peripheral blood mononuclear cells.	Theophylline	10-22	C-X-C motif chemokine ligand 8	Homo sapiens	97-110
7670094-4	1995	Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA).	Tretinoin	18-20	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
8593446-7	1995	rhIL-1 beta induced IL-8 production in a dose-dependent manner at concentrations of 1-100 units/ml, and theophylline (particularly at concentrations of 50 and 100 micrograms/ml), increased IL-8 production in the presence of rhIL-1 beta.	Theophylline	104-116	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
7670094-4	1995	Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA).	Butyric Acid	26-41	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
7670094-4	1995	Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA).	Butyric Acid	26-41	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
7670094-4	1995	Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA).	Butyric Acid	26-41	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
7670094-4	1995	Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA).	Tretinoin	127-129	C-X-C motif chemokine ligand 8	Homo sapiens	51-64
7670094-4	1995	Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA).	Tretinoin	127-129	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
7489182-9	1995	Lexipafant treatment significantly reduced serum IL-8 (P = 0.038), and IL-6 declined on day 1.	lexipafant	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
7670094-4	1995	Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA).	Tretinoin	127-129	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
7489942-0	1995	Interleukin 8 secretion by colonic crypt cells in vitro: response to injury suppressed by butyrate and enhanced in inflammatory bowel disease.	Butyrates	90-98	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
7556959-5	1995	Transcapillary diffusion of sodium fluorescein (NaF) was quantitated by video densitometry in the skin in all subjects on the 4th treatment day.	Fluorescein	28-46	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
7557080-8	1995	The chemokines IL-8 and IL-10, but not RANTES, increased [Ca2+]i in intraepithelial lymphocytes; this calcium mobilization was not affected by ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid, indicating that calcium is released from intracellular sources.	Calcium	102-109	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
7557080-8	1995	The chemokines IL-8 and IL-10, but not RANTES, increased [Ca2+]i in intraepithelial lymphocytes; this calcium mobilization was not affected by ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid, indicating that calcium is released from intracellular sources.	Calcium	230-237	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
7558346-2	1995	The aim of our study was to investigate whether MC are able to produce IL-8 after direct stimulation with clinically relevant bacteria.	Methylcholanthrene	48-50	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
7558346-3	1995	We observed a significant IL-8 response by the MC which were directly stimulated with viable staphylococci.	Methylcholanthrene	47-49	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
7559807-6	1995	Phosphorylation may not act directly on latent transcription factors, since bromophenacyl bromide, an inhibitor for the release of arachidonic acid from phorbol-12 myristate 13-acetate (PMA)-stimulated HL 60 cells, markedly depressed the induced mRNAs for IL-8, TNF-alpha, and IL-1 alpha and -beta.	Tetradecanoylphorbol Acetate	186-189	C-X-C motif chemokine ligand 8	Homo sapiens	256-260
7559807-0	1995	Inhibition of the arachidonic acid pathway prevents induction of IL-8 mRNA by phorbol ester and changes the release of IL-8 from HL 60 cells: differential inhibition of induced expression of IL-8, TNF-alpha, IL-1 alpha, and IL-1 beta.	Arachidonic Acid	18-34	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
7559807-0	1995	Inhibition of the arachidonic acid pathway prevents induction of IL-8 mRNA by phorbol ester and changes the release of IL-8 from HL 60 cells: differential inhibition of induced expression of IL-8, TNF-alpha, IL-1 alpha, and IL-1 beta.	Arachidonic Acid	18-34	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
8543371-6	1995	Pretreatment of neutrophils with the serine protease inhibitors PMSF or 3,4-DCI significantly reduced chemotaxis to C5a, fMLP and IL-8.	Phenylmethylsulfonyl Fluoride	64-68	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
8543371-6	1995	Pretreatment of neutrophils with the serine protease inhibitors PMSF or 3,4-DCI significantly reduced chemotaxis to C5a, fMLP and IL-8.	3,4-dichloroisocoumarin	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
7560091-5	1995	NECA 10 microM evoked IL-8 release from HMC-1, but CGS21680 10 microM had no effect.	Adenosine-5'-(N-ethylcarboxamide)	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
7559807-0	1995	Inhibition of the arachidonic acid pathway prevents induction of IL-8 mRNA by phorbol ester and changes the release of IL-8 from HL 60 cells: differential inhibition of induced expression of IL-8, TNF-alpha, IL-1 alpha, and IL-1 beta.	Arachidonic Acid	18-34	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
7559807-0	1995	Inhibition of the arachidonic acid pathway prevents induction of IL-8 mRNA by phorbol ester and changes the release of IL-8 from HL 60 cells: differential inhibition of induced expression of IL-8, TNF-alpha, IL-1 alpha, and IL-1 beta.	Phorbol Esters	78-91	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
7559807-6	1995	Phosphorylation may not act directly on latent transcription factors, since bromophenacyl bromide, an inhibitor for the release of arachidonic acid from phorbol-12 myristate 13-acetate (PMA)-stimulated HL 60 cells, markedly depressed the induced mRNAs for IL-8, TNF-alpha, and IL-1 alpha and -beta.	4-bromophenacyl bromide	76-97	C-X-C motif chemokine ligand 8	Homo sapiens	256-260
7560091-7	1995	Both theophylline and enprofylline 300 micro completely blocked the release of IL-8 by NECA.	Theophylline	5-17	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
7559807-8	1995	In contrast, ETYA increased the induced IL-8 RNA levels and stimulated the release for IL-8.	ETYA	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
7560091-7	1995	Both theophylline and enprofylline 300 micro completely blocked the release of IL-8 by NECA.	enprofylline	22-34	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
7559807-8	1995	In contrast, ETYA increased the induced IL-8 RNA levels and stimulated the release for IL-8.	ETYA	13-17	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
7559807-10	1995	However, the release of IL-8 protein was regulated by indomethacin and ketoconazole.	Indomethacin	54-66	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
7559807-10	1995	However, the release of IL-8 protein was regulated by indomethacin and ketoconazole.	Ketoconazole	71-83	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
7559807-11	1995	Our results indicate that arachidonic acid metabolites are mediators in the signal transduction pathway of IL-8 expression and that the involved second messengers are different from those which are important for the induction of TNF-alpha and IL-1 beta expression.	Arachidonic Acid	26-42	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
8845742-4	1995	in the human microglia cells ammonia decreased the constitutive secretion of interleukin-6, but it enhanced the stimulated (interleukin-1 alpha, tumor necrosis factor-alpha, gamma-interferon and gamma-interferon + tumor necrosis factor-alpha) secretion of interleukin-8.	Ammonia	29-36	C-X-C motif chemokine ligand 8	Homo sapiens	256-269
8576944-3	1995	Here we demonstrate that the four Ca(2+)-channel blockers, Amlodipine, Felodipine, Isradipine and Manidipine, at nanomolar concentrations, activate the transcription of the genes encoding IL-6 and IL-8 in primary human VSMC and fibroblasts.	Amlodipine	59-69	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
8576944-3	1995	Here we demonstrate that the four Ca(2+)-channel blockers, Amlodipine, Felodipine, Isradipine and Manidipine, at nanomolar concentrations, activate the transcription of the genes encoding IL-6 and IL-8 in primary human VSMC and fibroblasts.	Felodipine	71-81	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
8576944-3	1995	Here we demonstrate that the four Ca(2+)-channel blockers, Amlodipine, Felodipine, Isradipine and Manidipine, at nanomolar concentrations, activate the transcription of the genes encoding IL-6 and IL-8 in primary human VSMC and fibroblasts.	Isradipine	83-93	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
8576944-3	1995	Here we demonstrate that the four Ca(2+)-channel blockers, Amlodipine, Felodipine, Isradipine and Manidipine, at nanomolar concentrations, activate the transcription of the genes encoding IL-6 and IL-8 in primary human VSMC and fibroblasts.	manidipine	98-108	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
8845742-5	1995	In the astroglioma cell line, the stimulated release of tumor necrosis factor-alpha, interleukin-6 and interleukin-8 was diminished by ammonium acetate.	ammonium acetate	135-151	C-X-C motif chemokine ligand 8	Homo sapiens	103-116
7575568-0	1995	Nitric oxide regulates IL-8 expression in melanoma cells at the transcriptional level.	Nitric Oxide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
7575568-1	1995	We investigated the role of nitric oxide (NO) in the expression of interleukin-8 (IL-8) in the human melanoma cell line, G361.	Nitric Oxide	28-40	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
7575568-1	1995	We investigated the role of nitric oxide (NO) in the expression of interleukin-8 (IL-8) in the human melanoma cell line, G361.	Nitric Oxide	28-40	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
7575682-4	1995	Whereas migration by formyl-methionyl-leucyl-phenylalanine (fMLP)- or interleukin-8-activated electroporated neutrophils was strongly inhibited by ryanodine, chemotaxis induced by protein kinase C activators was not affected.	Ryanodine	147-156	C-X-C motif chemokine ligand 8	Homo sapiens	70-83
7575568-5	1995	The nitric oxide synthase inhibitor, NG-amino-L-homoarginine (NAHA), inhibited TNF-alpha-stimulated IL-8 promoter activity by 60%.	Nitric Oxide	4-16	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
7575568-5	1995	The nitric oxide synthase inhibitor, NG-amino-L-homoarginine (NAHA), inhibited TNF-alpha-stimulated IL-8 promoter activity by 60%.	ng-amino-l-homoarginine	37-60	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
7575568-5	1995	The nitric oxide synthase inhibitor, NG-amino-L-homoarginine (NAHA), inhibited TNF-alpha-stimulated IL-8 promoter activity by 60%.	naha	62-66	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
7486675-0	1995	IL-8 induces calcium mobilization in interleukin-2-activated natural killer cells independently of inositol 1,4,5 trisphosphate.	Calcium	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8549642-5	1995	Consistent with the effects on endothelin and ATP, NaF-induced inositol phosphate formation was also inhibited by cAMP generating agents to a similar extent.	Adenosine Triphosphate	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
8549642-5	1995	Consistent with the effects on endothelin and ATP, NaF-induced inositol phosphate formation was also inhibited by cAMP generating agents to a similar extent.	Inositol Phosphates	63-81	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
8549642-5	1995	Consistent with the effects on endothelin and ATP, NaF-induced inositol phosphate formation was also inhibited by cAMP generating agents to a similar extent.	Cyclic AMP	114-118	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
7545393-5	1995	We show that pyrrolidine dithiocarbamate strongly reduces the TNF alpha-mediated induction of E-selectin, VCAM-1, ICAM-1, PAI-1, tissue factor, IL-8 and I kappa B-alpha.	pyrrolidine dithiocarbamic acid	13-40	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
7677475-3	1995	METHODS: This initial study evaluated the impact of heparin-bonded CPB circuits on production of the cytokines interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-a), IL-6, and IL-8 in adults undergoing complex cardiac operations with prolonged CPB.	Heparin	52-59	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
7677475-6	1995	RESULTS: The levels of IL-6 and IL-8 increased in a time-dependent fashion in both groups, but the response was significantly less over time in the heparin-bonded group (p &lt; 0.05) for both IL-6 and IL-8.	Heparin	148-155	C-X-C motif chemokine ligand 8	Homo sapiens	201-205
8846658-1	1995	Sodium Fluoride (NaF) is the only medication so far clinically available with a bone formation stimulating property, through its peculiar mitogenic dose-dependent action on the osteoblast cell line.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
7669585-4	1995	Histological examination of the site of injection of CHO clones transfected with hu-IL-8, hu-MIP-1 alpha or mu-MIP-1 alpha showed predominantly neutrophilic infiltration.	cho	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
8846658-7	1995	Third, if one wants to avoid a calcium shift from cortical to trabecular bone and osteomalacia, one should use small doses of NaF, of the order of 50 mg/day.	Calcium	31-38	C-X-C motif chemokine ligand 8	Homo sapiens	126-129
11540313-4	1995	A new treatment program entailing intermittent slow release sodium fluoride (SR-NaF) with continuous calcium citrate may capture desirable qualities of fluoride without toxic effects, and be therapeutically efficacious in postmenopausal osteoporosis.	Sodium Fluoride	60-75	C-X-C motif chemokine ligand 8	Homo sapiens	80-83
8575568-5	1995	Incubation of the epithelial cultures in the presence of 0.1-10 micrograms.mL-1 erythromycin significantly blocked the HIE-induced release of IL-6, IL-8, and sICAM-1, at all concentrations of erythromycin investigated.	Erythromycin	80-92	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
8523463-4	1995	CINC is a rat equivalent of human interleukin-8.	Zinc	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	34-47
7642293-5	1995	The synthesis of IL-6 and IL-8 was also stimulated by 10 and 100 micrograms of both LPSs per ml, but IL-8 synthesis was not stimulated with E-LPS at 1 microgram/ml.	lpss	84-88	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
7642293-6	1995	Secretion of IL-6 and IL-8 into the culture medium was detected at 6 and 3 h, respectively, after exposure to P-LPS (10 micrograms/ml).	p-lps	110-115	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
7657801-8	1995	A second mechanism for trophozoite-induced IL-8 production involves trophozoite-target cell contact via a galactose-inhibitable amebic adherence protein, and appears to be mediated through increased intracellular calcium levels.	Galactose	106-115	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
7657801-8	1995	A second mechanism for trophozoite-induced IL-8 production involves trophozoite-target cell contact via a galactose-inhibitable amebic adherence protein, and appears to be mediated through increased intracellular calcium levels.	Calcium	213-220	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
7594798-5	1995	After treatment with macrolide antibiotics, significant reductions in the concentrations of defensins, IL-8 and neutrophil numbers in BALF of DPB patients were observed.	Macrolides	21-30	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
11540313-4	1995	A new treatment program entailing intermittent slow release sodium fluoride (SR-NaF) with continuous calcium citrate may capture desirable qualities of fluoride without toxic effects, and be therapeutically efficacious in postmenopausal osteoporosis.	Calcium Citrate	101-116	C-X-C motif chemokine ligand 8	Homo sapiens	80-83
11540313-4	1995	A new treatment program entailing intermittent slow release sodium fluoride (SR-NaF) with continuous calcium citrate may capture desirable qualities of fluoride without toxic effects, and be therapeutically efficacious in postmenopausal osteoporosis.	Fluorides	67-75	C-X-C motif chemokine ligand 8	Homo sapiens	80-83
7576392-9	1995	The polyampholyte-NaF delivery system with 1100 ppm F- was equivalent to the 2800 ppm F- dentifrice.	polyampholyte	4-17	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
7543020-5	1995	Induction of IL-8 was UV-B dose dependent and blocked by cyclohexamide, indicating that de novo protein synthesis is required for its expression.	4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]piperidine-2,6-dione	57-70	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
7487568-1	1995	Fluoride-mediated inhibition of peroxidase potential activity in human saliva was investigated using NaF, NH4F, CaF2, Na2PO3F (MFP), SnF2 and TiF4.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
7543732-5	1995	Apigenin also inhibited IL-1 alpha-induced prostaglandin synthesis and TNF-alpha-induced IL-6 and IL-8 production, suggesting that the hydroxyflavones may act as general inhibitors of cytokine-induced gene expression.	hydroxyflavones	135-150	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
7626291-9	1995	We did, however, demonstrate a dose-dependent decrease in IL-8 release and IL-8 mRNA induction in RSV-infected epithelial treated with the antioxidants dimethyl sulfoxide (DMSO) or 5,5-dimethyl-1-pyrroline-N-oxide (DMPO).	Dimethyl Sulfoxide	152-170	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
7626291-9	1995	We did, however, demonstrate a dose-dependent decrease in IL-8 release and IL-8 mRNA induction in RSV-infected epithelial treated with the antioxidants dimethyl sulfoxide (DMSO) or 5,5-dimethyl-1-pyrroline-N-oxide (DMPO).	Dimethyl Sulfoxide	152-170	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
7626291-9	1995	We did, however, demonstrate a dose-dependent decrease in IL-8 release and IL-8 mRNA induction in RSV-infected epithelial treated with the antioxidants dimethyl sulfoxide (DMSO) or 5,5-dimethyl-1-pyrroline-N-oxide (DMPO).	Dimethyl Sulfoxide	172-176	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
7626291-9	1995	We did, however, demonstrate a dose-dependent decrease in IL-8 release and IL-8 mRNA induction in RSV-infected epithelial treated with the antioxidants dimethyl sulfoxide (DMSO) or 5,5-dimethyl-1-pyrroline-N-oxide (DMPO).	Dimethyl Sulfoxide	172-176	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
7626291-9	1995	We did, however, demonstrate a dose-dependent decrease in IL-8 release and IL-8 mRNA induction in RSV-infected epithelial treated with the antioxidants dimethyl sulfoxide (DMSO) or 5,5-dimethyl-1-pyrroline-N-oxide (DMPO).	5,5-dimethyl-1-pyrroline-1-oxide	181-213	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
7626291-9	1995	We did, however, demonstrate a dose-dependent decrease in IL-8 release and IL-8 mRNA induction in RSV-infected epithelial treated with the antioxidants dimethyl sulfoxide (DMSO) or 5,5-dimethyl-1-pyrroline-N-oxide (DMPO).	5,5-dimethyl-1-pyrroline-1-oxide	181-213	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
7626291-9	1995	We did, however, demonstrate a dose-dependent decrease in IL-8 release and IL-8 mRNA induction in RSV-infected epithelial treated with the antioxidants dimethyl sulfoxide (DMSO) or 5,5-dimethyl-1-pyrroline-N-oxide (DMPO).	5,5-dimethyl-1-pyrroline-1-oxide	215-219	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
7487568-2	1995	At pH 5.5 and for a 20 mM F concentration, the inhibition percentages increased from 2% for MFP and 5% for CaF2 to 61% for NaF and 65% for NH4F, while a 100% inhibition was observed at 10 mM for TiF4 and at 5 mM for SnF2.	Fluorine	26-27	C-X-C motif chemokine ligand 8	Homo sapiens	123-126
8546810-9	1995	Addition of TSH (1 mU/ml) produced an increase in the level of IL-1 alpha mRNA in primary TFC and HTori3 cells, at 12 and 24 h. TSH had no significant effect on the expression of IL-6 or IL-8 mRNA.	Thyrotropin	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
8528601-0	1995	Pharmacological modulation of IL-6 and IL-8 secretion by the H1-antagonist decarboethoxy-loratadine and dexamethasone by human mast and basophilic cell lines.	decarboethoxy-loratadine	75-99	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
7622884-6	1995	Interleukin-8 (IL-8) and leukotriene B4 (LTB4) were released in greater quantities by adult monocytes in response to either GBS or lipopolysaccharide.	gbs	124-127	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
7622884-6	1995	Interleukin-8 (IL-8) and leukotriene B4 (LTB4) were released in greater quantities by adult monocytes in response to either GBS or lipopolysaccharide.	gbs	124-127	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
7622884-9	1995	IL-8 and LTB4 accounted for the majority of chemoattractant activity released in response to GBS.	gbs	93-96	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
7622884-10	1995	Decreased production of LTB4 and IL-8 may contribute to the neonate"s poor host response to GBS.	gbs	92-95	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
8570304-6	1995	Proinflammatory cytokines and proteinases were generally elevated, and interleukin-8 (IL-8) concentration correlated inversely with oxygen saturation (SaO2).	Oxygen	132-138	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
8570304-6	1995	Proinflammatory cytokines and proteinases were generally elevated, and interleukin-8 (IL-8) concentration correlated inversely with oxygen saturation (SaO2).	Oxygen	132-138	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
8570304-6	1995	Proinflammatory cytokines and proteinases were generally elevated, and interleukin-8 (IL-8) concentration correlated inversely with oxygen saturation (SaO2).	sao2	151-155	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
8570304-6	1995	Proinflammatory cytokines and proteinases were generally elevated, and interleukin-8 (IL-8) concentration correlated inversely with oxygen saturation (SaO2).	sao2	151-155	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
7546131-6	1995	Results of studies have varied, but the largest ever double-blind NaF/SMFP head-to-head dentifrice trial yet published (Stephen et al., 1994) has indicated a 6.4% significant benefit in favor of NaF (in silica) over SMFP.	Silicon Dioxide	203-209	C-X-C motif chemokine ligand 8	Homo sapiens	195-198
7546131-8	1995	In relation to root caries, Jensen and Kohout (1988) reported a 41.4% DFS significant reduction in subjects who used a NaF/silica dentifrice at 1100 ppm F, over a one-year period.	Silicon Dioxide	123-129	C-X-C motif chemokine ligand 8	Homo sapiens	119-122
7677428-5	1995	Patients who had high blood levels of pentachlorophenol and abnormal lymphocyte stimulation also had increased proportions of blood monocytes in blood (p &lt; .05), as well as increased IL-8 serum levels (p &lt; .02).	Pentachlorophenol	38-55	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
7555210-0	1995	Cefodizime modulates in vitro tumor necrosis factor-alpha, interleukin-6 and interleukin-8 release from human peripheral monocytes.	cefodizime	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	77-90
7670776-2	1995	Significant stimulation of IL-1ra and sTNFR p75 as well as inhibition of IL-8 production of PBMC were associated with clinical improvement observed in patients treated with MTX.	Methotrexate	173-176	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
7789553-6	1995	A significant positive correlation was observed between the levels of reactive oxygen species and IL-8.	Reactive Oxygen Species	70-93	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
7540987-0	1995	Upregulation of interleukin-8 receptor in human polymorphonuclear neutrophils by formyl peptide and lipopolysaccharide.	formyl peptide	81-95	C-X-C motif chemokine ligand 8	Homo sapiens	16-29
7577839-4	1995	IL-8 production in PBMC was closely related to the clinical severity of psoriasis and to the response to treatment, including systemic methotrexate (MTX) treatment and tonsillectomy.	Methotrexate	135-147	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
7577839-4	1995	IL-8 production in PBMC was closely related to the clinical severity of psoriasis and to the response to treatment, including systemic methotrexate (MTX) treatment and tonsillectomy.	Methotrexate	149-152	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
7615975-4	1995	Transforming growth factor (TGF)-alpha, epidermal growth factor, and phorbol myristate acetate also enhanced the secretion of VPF/VEGF by keratinocytes; in contrast, a number of other cytokines including interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor-alpha, interferon-gamma, and transforming growth factor-beta did not induce VPF/VEGF secretion.	Tetradecanoylphorbol Acetate	69-94	C-X-C motif chemokine ligand 8	Homo sapiens	230-234
7637390-1	1995	Interleukin-8 (IL-8) mRNA was rapidly, but not permanently, induced at high levels by phorbol-12myristate-13acetate (PMA) in HL60 cells.	Tetradecanoylphorbol Acetate	86-115	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
7637390-1	1995	Interleukin-8 (IL-8) mRNA was rapidly, but not permanently, induced at high levels by phorbol-12myristate-13acetate (PMA) in HL60 cells.	Tetradecanoylphorbol Acetate	86-115	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
7637390-1	1995	Interleukin-8 (IL-8) mRNA was rapidly, but not permanently, induced at high levels by phorbol-12myristate-13acetate (PMA) in HL60 cells.	Tetradecanoylphorbol Acetate	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
7637390-1	1995	Interleukin-8 (IL-8) mRNA was rapidly, but not permanently, induced at high levels by phorbol-12myristate-13acetate (PMA) in HL60 cells.	Tetradecanoylphorbol Acetate	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
7637390-3	1995	However, the rate of transient induction kinetics was modulated by cycloheximide (CHX) indicating that secondary response genes are involved in the regulation of IL-8 RNA levels.	Cycloheximide	67-80	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
7637390-3	1995	However, the rate of transient induction kinetics was modulated by cycloheximide (CHX) indicating that secondary response genes are involved in the regulation of IL-8 RNA levels.	Cycloheximide	82-85	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
7794282-0	1995	Nitric oxide regulation of IL-8 expression in human endothelial cells.	Nitric Oxide	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
7794282-2	1995	We examined the role of nitric oxide (NO) in IL-8 regulation.	Nitric Oxide	24-36	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
7794282-3	1995	The NO synthase inhibitor, (L)-NG-nitroarginine methyl ester (L-NAME), inhibited the TNF-stimulated IL-8 production in the human endothelial cell line, ECV304, in a dose-dependent manner without affecting cellular viability (TNF alone, 5.5 +/- 0.9 ng/ml; TNF + 5 mM L-NAME, 2.4 +/- 0.5 ng/ml).	(l)-ng-nitroarginine methyl ester	27-60	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
7794282-3	1995	The NO synthase inhibitor, (L)-NG-nitroarginine methyl ester (L-NAME), inhibited the TNF-stimulated IL-8 production in the human endothelial cell line, ECV304, in a dose-dependent manner without affecting cellular viability (TNF alone, 5.5 +/- 0.9 ng/ml; TNF + 5 mM L-NAME, 2.4 +/- 0.5 ng/ml).	NG-Nitroarginine Methyl Ester	62-68	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
7794282-4	1995	Moreover, exogenously added NO produced by the spontaneous NO generating compounds, S-Nitroso-N-acetyl-D,L-pennicillamine (SNAP) and Ethanamine, 2,2"-(hydroxynitrosohydrazono)bis- (DETA NONOate), induced a dose-dependent release of IL-8 from these cells.	s-nitroso-n-acetyl-d,l-pennicillamine	84-121	C-X-C motif chemokine ligand 8	Homo sapiens	232-236
7794282-4	1995	Moreover, exogenously added NO produced by the spontaneous NO generating compounds, S-Nitroso-N-acetyl-D,L-pennicillamine (SNAP) and Ethanamine, 2,2"-(hydroxynitrosohydrazono)bis- (DETA NONOate), induced a dose-dependent release of IL-8 from these cells.	2,2"-(hydroxynitrosohydrazono)bis- (deta nonoate	145-193	C-X-C motif chemokine ligand 8	Homo sapiens	232-236
7794282-5	1995	Maximal stimulation of IL-8 was found to be 1.2 +/- 0.1 ng/ml with the 1 mM concentration of SNAP and 1.6 +/- 0.1 ng/ml with the 2 mM concentration of DETA NONOate.	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	151-163	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
7759889-0	1995	Increased cell-associated IL-8 in human exudative and A23187-treated peripheral blood neutrophils.	Calcimycin	54-60	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
7759889-5	1995	Furthermore, cell-associated IL-8 in peripheral blood neutrophils increased 20-fold during incubation at 37 degrees C in vitro and was increased over 200-fold after treatment with the Ca2+ ionophore A23187.	Calcimycin	199-205	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
7737976-2	1995	This study defines an important region between Cys7 and Cys50 that, together with the Glu4-Leu5-Arg6 sequence of the NH2 terminus, accounts for the high affinity binding of IL-8 to the IL-8 A receptor on leukocytes.	CYS7	47-51	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
7759889-6	1995	More than 35% of the cell-associated IL-8 could be released by stimulation with either Ca2+ ionophore A23187 or phorbol myristate acetate.	Calcimycin	102-108	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
7759889-6	1995	More than 35% of the cell-associated IL-8 could be released by stimulation with either Ca2+ ionophore A23187 or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	112-137	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
7759889-7	1995	IL-8 was localized by sucrose gradient centrifugation to a subcellular fraction of heterogeneous, light membranous organelles.	Sucrose	22-29	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
7759889-8	1995	The accumulation of IL-8 within these organelles is inhibited by cycloheximide but not actinomycin D, suggesting that IL-8 accumulation is under translational, rather than transcriptional control.	Cycloheximide	65-78	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
7759889-8	1995	The accumulation of IL-8 within these organelles is inhibited by cycloheximide but not actinomycin D, suggesting that IL-8 accumulation is under translational, rather than transcriptional control.	Cycloheximide	65-78	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
7590784-9	1995	Similarly, a 300-fold molar excess of anti-IL-8 antibody [10(-5) M] was necessary to abrogate the increase in cytosolic free calcium in neutrophils stimulated with 4 x 10(-8) M rhIL-8.	Calcium	125-132	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
7590896-3	1995	Oxyradical production is one of the lytic mechanisms used by phagocytes, and IL-8 is shown to activate this function, which does not occur if neutrophils are pretreated with the protein kinase C inhibitor, staurosporine, but is increased by R59022, a dyacylglycerol kinase inhibitor.	Staurosporine	206-219	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
7590896-3	1995	Oxyradical production is one of the lytic mechanisms used by phagocytes, and IL-8 is shown to activate this function, which does not occur if neutrophils are pretreated with the protein kinase C inhibitor, staurosporine, but is increased by R59022, a dyacylglycerol kinase inhibitor.	R 59022	241-247	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
7590896-4	1995	The IL-8 effect is mediated by protein kinase C, which is potentiated by the calcium flux induced by the interaction between antibody coating tumour target and Fc gamma RIII on effector cells, as previously demonstrated.	Calcium	77-84	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
7790770-6	1995	However, neutrophils pretreated with interleukin-8 ingested IgA-opsonized microspheres and released superoxide when exposed to IgA antibody-antigen complexes.	Superoxides	100-110	C-X-C motif chemokine ligand 8	Homo sapiens	37-50
7763262-0	1995	Regulation of interleukin-8 gene expression by all-trans retinoic acid.	Tretinoin	57-70	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
7763262-1	1995	We have studied the relationship between interleukin-8 (IL-8) and interleukin-1 alpha (IL-1 alpha) release after stimulation with all-trans retinoic acid (ATRA) and tumor necrosis factor-alpha (TNF-alpha) in the human epithelial ovarian cancer cell line HOC-7.	Tretinoin	140-153	C-X-C motif chemokine ligand 8	Homo sapiens	41-54
7763262-1	1995	We have studied the relationship between interleukin-8 (IL-8) and interleukin-1 alpha (IL-1 alpha) release after stimulation with all-trans retinoic acid (ATRA) and tumor necrosis factor-alpha (TNF-alpha) in the human epithelial ovarian cancer cell line HOC-7.	Tretinoin	140-153	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
7763262-1	1995	We have studied the relationship between interleukin-8 (IL-8) and interleukin-1 alpha (IL-1 alpha) release after stimulation with all-trans retinoic acid (ATRA) and tumor necrosis factor-alpha (TNF-alpha) in the human epithelial ovarian cancer cell line HOC-7.	Tretinoin	155-159	C-X-C motif chemokine ligand 8	Homo sapiens	41-54
7763262-1	1995	We have studied the relationship between interleukin-8 (IL-8) and interleukin-1 alpha (IL-1 alpha) release after stimulation with all-trans retinoic acid (ATRA) and tumor necrosis factor-alpha (TNF-alpha) in the human epithelial ovarian cancer cell line HOC-7.	Tretinoin	155-159	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
7763262-2	1995	Both IL-1 alpha and IL-8 protein release were enhanced by treatment with ATRA and TNF-alpha after 48 h exposure.	Tretinoin	73-77	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
7763262-3	1995	Blocking of IL-1 alpha activity in HOC-7 cells with either IL-1 receptor antagonist (IL-1ra) or a neutralizing antibody directed against IL-1 alpha resulted in a dose-dependent decrease of IL-8 release by ATRA, TNF-alpha and IL-1 alpha treated HOC-7 cells.	Tretinoin	205-209	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
7737976-2	1995	This study defines an important region between Cys7 and Cys50 that, together with the Glu4-Leu5-Arg6 sequence of the NH2 terminus, accounts for the high affinity binding of IL-8 to the IL-8 A receptor on leukocytes.	CYS7	47-51	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
8589272-2	1995	Upon granulocytic differentiation with all-trans retinoic acid (ATRA) or the combination of ATRA and granulocyte-colony-stimulating factor (G-CSF), significant amounts of IL-1 beta and IL-8 mRNAs accumulated in both cell types.	Tretinoin	49-62	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
7614647-0	1995	Methylprednisolone inhibits increase of interleukin 8 and 6 during open heart surgery.	Methylprednisolone	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
7614647-3	1995	This prospective study was conducted to investigate whether methylprednisolone (MP) pretreatment (30 mg.kg-1 before CPB and before declamping of aorta) influenced the production of IL-8 and 6 in the peripheral circulation in 27 patients undergoing elective coronary artery bypass surgery.	Methylprednisolone	60-78	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
7614647-3	1995	This prospective study was conducted to investigate whether methylprednisolone (MP) pretreatment (30 mg.kg-1 before CPB and before declamping of aorta) influenced the production of IL-8 and 6 in the peripheral circulation in 27 patients undergoing elective coronary artery bypass surgery.	Methylprednisolone	80-82	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
8589272-2	1995	Upon granulocytic differentiation with all-trans retinoic acid (ATRA) or the combination of ATRA and granulocyte-colony-stimulating factor (G-CSF), significant amounts of IL-1 beta and IL-8 mRNAs accumulated in both cell types.	Tretinoin	64-68	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
7738357-0	1995	Interleukin-8 and GRO alpha prime human neutrophils for superoxide anion production and induce up-regulation of N-formyl peptide receptors.	Superoxides	56-72	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
7539029-9	1995	It is interesting that the major structural difference between IL-8 and PF4 is the presence of the NH2-terminal ELR (Glu-Leu-Arg) motif that precedes the first cysteine amino acid residue of IL-8 and is important in ligand/receptor interactions.	Glutamic Acid	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
7539029-9	1995	It is interesting that the major structural difference between IL-8 and PF4 is the presence of the NH2-terminal ELR (Glu-Leu-Arg) motif that precedes the first cysteine amino acid residue of IL-8 and is important in ligand/receptor interactions.	leucylarginine	121-128	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
7539029-9	1995	It is interesting that the major structural difference between IL-8 and PF4 is the presence of the NH2-terminal ELR (Glu-Leu-Arg) motif that precedes the first cysteine amino acid residue of IL-8 and is important in ligand/receptor interactions.	cysteine amino acid	160-179	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
7539029-9	1995	It is interesting that the major structural difference between IL-8 and PF4 is the presence of the NH2-terminal ELR (Glu-Leu-Arg) motif that precedes the first cysteine amino acid residue of IL-8 and is important in ligand/receptor interactions.	cysteine amino acid	160-179	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
7542063-3	1995	IL-4, but not SCF, enhanced ionomycin-induced transcription and secretion of several genes, including the cytokines IL-3, IL-4, granulocyte/macrophage-colony-stimulating factor, IL-8 and the receptor for IL-6 in the human HMC-1 mast cell line.	Ionomycin	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
7542097-0	1995	Expression of granulocyte/macrophage-colony-stimulating factor, interleukin-8 and RANTES in the bronchial epithelium of mild asthmatics is down-regulated by inhaled beclomethasone dipropionate.	Beclomethasone	165-192	C-X-C motif chemokine ligand 8	Homo sapiens	64-77
7722453-6	1995	By this measure, IL-8- or LTB4-treated PMN adhered loosely to fibrin, since 10 kD rhodamine-polyethylene glycol permeated into the contact zones between these cells and the underlying fibrin gel.	rhodamine-polyethylene glycol	82-111	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
7722453-7	1995	PMN stimulated with FMLP and IL-8, or FMLP and LTB4, exhibited very little migration through fibrin gels, and three times as many of these cells excluded 10 kD rhodamine-polyethylene glycol from their zones of contact with fibrin as PMN stimulated with IL-8 or LTB4 alone.	rhodamine-polyethylene glycol	160-189	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
7722326-9	1995	The MBP-stimulated production of IL-8 was inhibited by actinomycin D, but not by cyclosporin A.	Dactinomycin	55-68	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
7738357-3	1995	IL-8 and GRO alpha themselves did not stimulate production of significant amounts of superoxide anions but potentiated N-formyl peptide-induced superoxide anion production in a concentration-dependent manner.	n-formyl peptide	119-135	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
7738357-4	1995	Binding measurements by flow cytometry at 37 degrees C with fluorescein-labeled N-formyl peptide revealed enhanced total N-formyl peptide binding after pretreatment of neutrophils with IL-8 and GRO alpha.	Fluorescein	60-71	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
7738357-4	1995	Binding measurements by flow cytometry at 37 degrees C with fluorescein-labeled N-formyl peptide revealed enhanced total N-formyl peptide binding after pretreatment of neutrophils with IL-8 and GRO alpha.	n-formyl peptide	80-96	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
7738357-4	1995	Binding measurements by flow cytometry at 37 degrees C with fluorescein-labeled N-formyl peptide revealed enhanced total N-formyl peptide binding after pretreatment of neutrophils with IL-8 and GRO alpha.	n-formyl peptide	121-137	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
7738357-6	1995	This study indicates that IL-8 and GRO alpha, in addition to their known chemotactic activity, prime neutrophils for superoxide anion production, presumably by up-regulating the number of receptors for strong superoxide-anion-triggering stimuli.	Superoxides	117-133	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
7738357-6	1995	This study indicates that IL-8 and GRO alpha, in addition to their known chemotactic activity, prime neutrophils for superoxide anion production, presumably by up-regulating the number of receptors for strong superoxide-anion-triggering stimuli.	Superoxides	209-225	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
7740640-1	1995	In order to evaluate the effect of sodium fluoride (NaF) on bone biomechanical competence, iliac crest biopsies were taken before and after one year of treatment in 12 osteoporotic patients, and before and after five years of treatment in 14 patients.	Sodium Fluoride	35-50	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
7706709-4	1995	Stimulation of T lymphocytes or T cell clones with IL-8 led to generation of inositol trisphosphate and calcium flux.	inositol 1,2,3-trisphosphate	77-99	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
7706709-4	1995	Stimulation of T lymphocytes or T cell clones with IL-8 led to generation of inositol trisphosphate and calcium flux.	Calcium	104-111	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
7706709-5	1995	In addition, when T cells were prelabeled with [3H]oleic acid, IL-8 caused a long lasting, time- and dose-related increase in [3H]phosphatidylethanol (PtE), indicating activation of phospholipase D (PLD).	[3h]oleic acid	47-61	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
7706709-5	1995	In addition, when T cells were prelabeled with [3H]oleic acid, IL-8 caused a long lasting, time- and dose-related increase in [3H]phosphatidylethanol (PtE), indicating activation of phospholipase D (PLD).	[3h]phosphatidylethanol	126-149	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
7706709-5	1995	In addition, when T cells were prelabeled with [3H]oleic acid, IL-8 caused a long lasting, time- and dose-related increase in [3H]phosphatidylethanol (PtE), indicating activation of phospholipase D (PLD).	pte	151-154	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
7535813-6	1995	Staurosporine inhibits freshly isolated T lymphocyte chemotaxis toward IL-8, whereas tyrphostin 23 inhibits chemotaxis of overnight cultured and anti-CD3-activated T lymphocytes toward IL-1 alpha.	Staurosporine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
7615691-4	1995	Pretreatment of polymorphonuclear leucocytes with 50 microM BAPTA/AM, an intracellular calcium chelator, lowered the basal level in cell calcium and inhibited the transient calcium rise stimulated by 2 nM interleukin-8, 2 nM C5a, and 10 nM N-formylmethionyl-leucyl-phenylalanine.	N-Formylmethionine Leucyl-Phenylalanine	240-278	C-X-C motif chemokine ligand 8	Homo sapiens	205-218
7751024-3	1995	Stimulation of non-IL-4-treated cells with ionomycin (10 microM) for periods of 30 min to 8 hr induced expression of mRNA encoding IL-3, IL-4 and IL-8 but was without effect on levels of mRNA for tumour necrosis factor (TNF)-alpha or beta-actin.	Ionomycin	43-52	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
7615691-1	1995	Chemoattractants such as interleukin-8, C5a and N-formylmethionyl-leucyl-phenylalanine induce a cytosolic calcium rise involved in triggering the secretory functions of human polymorphonuclear leucocytes.	Calcium	106-113	C-X-C motif chemokine ligand 8	Homo sapiens	25-38
7615691-4	1995	Pretreatment of polymorphonuclear leucocytes with 50 microM BAPTA/AM, an intracellular calcium chelator, lowered the basal level in cell calcium and inhibited the transient calcium rise stimulated by 2 nM interleukin-8, 2 nM C5a, and 10 nM N-formylmethionyl-leucyl-phenylalanine.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	60-65	C-X-C motif chemokine ligand 8	Homo sapiens	205-218
7609578-8	1995	NaF (10 mM), which stimulates ACh release, produced parallel increases in EPPs and perineural Ca2+ currents.	Acetylcholine	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
7875467-6	1995	Activation of PKC by phorbol myristate acetate also stimulated IL-8 production; however, the effects of IL-1 beta or TNF-alpha did not require PKC, as shown by the PKC inhibitor staurosporin or PKC depletion.	Tetradecanoylphorbol Acetate	21-46	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
7875467-8	1995	However, induction of IL-8 by IL-1 beta or TNF-alpha was reduced by the PTK inhibitors herbimycin (by 79% or 89%, respectively) and genistein (by &gt; 95%).	herbimycin	87-97	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
7875467-8	1995	However, induction of IL-8 by IL-1 beta or TNF-alpha was reduced by the PTK inhibitors herbimycin (by 79% or 89%, respectively) and genistein (by &gt; 95%).	Genistein	132-141	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
7751024-5	1995	More notably, the IL-4 treatment produced a pronounced elevation of mRNA for IL-3 and IL-8 when the cells were subsequently activated with ionomycin.	Ionomycin	139-148	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
21556582-6	1995	Similar changes in IL-6 and IL-8 mRNA expression were noted when NUGC3 cells were cultured with paraformaldehyde-fixed 3T3 cells or the 3T3 membrane fraction, thereby supporting this notion.	paraform	96-112	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
7531692-3	1995	Examination of the sequences of the CXC chemokines reveals that the highly conserved leucine, corresponding to Leu25 in IL-8, is always replaced by tyrosine in CC chemokines.	Leucine	85-92	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
7864891-2	1995	Phorbol 12, 13 dibutyrate did not affect the IL-4-induced B cell growth; however, it reversed the IL-8-mediated inhibition, and this reversal was blocked by H7 (a protein kinase C inhibitor), but not by H8 (a protein kinase A inhibitor).	Phorbol 12,13-Dibutyrate	0-25	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
7620820-0	1995	Inhibitory effect of FUT-175 on the production of interleukin 8 and polymorphonuclear leukocyte elastase.	nafamostat	21-28	C-X-C motif chemokine ligand 8	Homo sapiens	50-63
7531692-3	1995	Examination of the sequences of the CXC chemokines reveals that the highly conserved leucine, corresponding to Leu25 in IL-8, is always replaced by tyrosine in CC chemokines.	Tyrosine	148-156	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
7531692-10	1995	Additionally, the Leu25--&gt;Tyr mutation introduces a novel monocyte chemoattractant activity into IL-8.	Tyrosine	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
7531692-11	1995	We therefore studied the displacement of [125I]MIP-1 alpha by IL-8 Leu25--&gt;Tyr from the CC-CKR-1 receptor.	Tyrosine	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
7531627-0	1995	IL-8/IL-8 receptor expression in psoriasis and the response to systemic tacrolimus (FK506) therapy.	Tacrolimus	72-82	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
7531627-0	1995	IL-8/IL-8 receptor expression in psoriasis and the response to systemic tacrolimus (FK506) therapy.	Tacrolimus	72-82	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
7531627-0	1995	IL-8/IL-8 receptor expression in psoriasis and the response to systemic tacrolimus (FK506) therapy.	Tacrolimus	84-89	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
7531627-0	1995	IL-8/IL-8 receptor expression in psoriasis and the response to systemic tacrolimus (FK506) therapy.	Tacrolimus	84-89	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
7531627-5	1995	IL-8 mRNA was not detected in the skin of any patient after the start of systemic tacrolimus therapy; IL-1 beta, IL-6 and IFN-gamma transcripts were also reduced.	Tacrolimus	82-92	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
7531627-8	1995	Estimation of circulating IL-8 levels by enzyme immunoassay showed that all patients with detectable IL-8 before treatment had decreased levels in response to treatment with tacrolimus; reductions in PASI scores were accompanied by decreases in IL-8 levels, that varied both in rate and extent.	Tacrolimus	174-184	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
7531627-8	1995	Estimation of circulating IL-8 levels by enzyme immunoassay showed that all patients with detectable IL-8 before treatment had decreased levels in response to treatment with tacrolimus; reductions in PASI scores were accompanied by decreases in IL-8 levels, that varied both in rate and extent.	Tacrolimus	174-184	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
7531627-8	1995	Estimation of circulating IL-8 levels by enzyme immunoassay showed that all patients with detectable IL-8 before treatment had decreased levels in response to treatment with tacrolimus; reductions in PASI scores were accompanied by decreases in IL-8 levels, that varied both in rate and extent.	Tacrolimus	174-184	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
7531627-11	1995	They further suggest that interference with IL-8 production and/or that of other key chemokines may be an important mechanism underlying the therapeutic efficacy of tacrolimus, and other agents such as cyclosporin A, with similar molecular actions.	Tacrolimus	165-175	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
7531627-11	1995	They further suggest that interference with IL-8 production and/or that of other key chemokines may be an important mechanism underlying the therapeutic efficacy of tacrolimus, and other agents such as cyclosporin A, with similar molecular actions.	Cyclosporine	202-215	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
7531729-5	1995	When tested at 5 x 10(-9) mol/L, the decrease in histamine release by RANTES was 69.2% +/- 3.5%, by MIP-1 alpha 48.8% +/- 3.1%, by MIP-1 beta 42.9% +/- 3.1%, by PF4 56.5% +/- 2.9%, by IL-8 41.2% +/- 2.2, by CTAP III 27% +/- 4.4%, and by IP-10 15.3% +/- 2.6%.	Histamine	49-58	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
7531729-10	1995	We have therefore characterized RANTES, MIP-1 alpha, MIP-1 beta, CTAP III, PF4, IL-8, and IP-10 as inhibitors of MCAF-induced histamine release.	Histamine	126-135	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
7759774-0	1995	Enhancement of polymorphonuclear cell phagocytosis by lipid A-activated monocytes via cell-to-cell contact: a possible role for membrane-associated interleukin-6 and interleukin-8.	Lipid A	54-61	C-X-C motif chemokine ligand 8	Homo sapiens	166-179
7822801-5	1995	Morphine but not opioid peptides interfered with activation and/or chemotaxis of the granulocytes induced by TNF-alpha, IL-1 alpha, IL-8, and FMLP (chemotactic peptide).	Morphine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
7860742-7	1995	M. tuberculosis and its cell wall components lipoarabinomannan (LAM), lipomannan (LM), and phosphoinositolmannoside (PIM) stimulated IL-8 protein release and mRNA expression in vitro from alveolar macrophages, but deacylated LAM did not.	lipoarabinomannan	45-62	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
7860742-7	1995	M. tuberculosis and its cell wall components lipoarabinomannan (LAM), lipomannan (LM), and phosphoinositolmannoside (PIM) stimulated IL-8 protein release and mRNA expression in vitro from alveolar macrophages, but deacylated LAM did not.	lipoarabinomannan	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
7860742-7	1995	M. tuberculosis and its cell wall components lipoarabinomannan (LAM), lipomannan (LM), and phosphoinositolmannoside (PIM) stimulated IL-8 protein release and mRNA expression in vitro from alveolar macrophages, but deacylated LAM did not.	lipomannan	70-80	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
7860742-7	1995	M. tuberculosis and its cell wall components lipoarabinomannan (LAM), lipomannan (LM), and phosphoinositolmannoside (PIM) stimulated IL-8 protein release and mRNA expression in vitro from alveolar macrophages, but deacylated LAM did not.	lipomannan	82-84	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
7812007-4	1995	IL-8, NAP-2, and GRO alpha stimulated similar increases in the level of cytoplasmic free calcium.	Calcium	89-96	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
7860742-7	1995	M. tuberculosis and its cell wall components lipoarabinomannan (LAM), lipomannan (LM), and phosphoinositolmannoside (PIM) stimulated IL-8 protein release and mRNA expression in vitro from alveolar macrophages, but deacylated LAM did not.	phosphatidylinositol mannoside	91-115	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
7860742-7	1995	M. tuberculosis and its cell wall components lipoarabinomannan (LAM), lipomannan (LM), and phosphoinositolmannoside (PIM) stimulated IL-8 protein release and mRNA expression in vitro from alveolar macrophages, but deacylated LAM did not.	phosphatidylinositol mannoside	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
7829234-8	1995	In the absence of stimuli, TAM produced higher levels, compared to monocytes, of IL-6 and IL-8 but not of IL-1 and TNF.	tam	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
7812007-6	1995	In contrast, only IL-8 enhanced the formation of phosphatidylethanol (PEt), the product catalyzed by phospholipase D (PLD) in the presence of ethanol.	phosphatidylethanol	49-68	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
7812007-6	1995	In contrast, only IL-8 enhanced the formation of phosphatidylethanol (PEt), the product catalyzed by phospholipase D (PLD) in the presence of ethanol.	Ethanol	61-68	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
7812007-7	1995	The formation of PEt stimulated by IL-8 was inhibited by pertussis toxin and the tyrosine kinase inhibitors erbstatin and herbimycin A.	erbstatin	108-117	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
7851404-6	1995	The 72-residue interleukin-8 sequence starts with a serine residue, which can be oxidised under mild conditions to give a reactive glyoxylyl function which is then reacted with a nucleophilic fluorescein derivative.	Serine	52-58	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
7851404-6	1995	The 72-residue interleukin-8 sequence starts with a serine residue, which can be oxidised under mild conditions to give a reactive glyoxylyl function which is then reacted with a nucleophilic fluorescein derivative.	Fluorescein	192-203	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
7812007-7	1995	The formation of PEt stimulated by IL-8 was inhibited by pertussis toxin and the tyrosine kinase inhibitors erbstatin and herbimycin A.	herbimycin	122-134	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
7812007-8	1995	The ability of IL-8 to stimulate the activity of PLD was additively enhanced, or primed, by cytochalasin B and by tumor necrosis factor alpha.	Cytochalasin B	92-106	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
7618641-3	1995	HD using PMMA dialyzers also increased plasma IL-8 levels and induced slight expression of IL-8 mRNA.	Polymethyl Methacrylate	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
7618641-3	1995	HD using PMMA dialyzers also increased plasma IL-8 levels and induced slight expression of IL-8 mRNA.	Polymethyl Methacrylate	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
8624224-9	1995	The following can be concluded from this study: 1) silica based dentifrices containing MFP and NaF are effective at remineralizing caries-like lesions in both enamel and dentin; 2) there was no statistical difference between NaF and MFP in their ability to promote remineralization; and 3) pyrophosphate does not interfere with the remineralizing effects of NaF.	Silicon Dioxide	51-57	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
7813101-3	1995	Spontaneous and lipopolysaccharide (LPS)-induced IL-8 release was significantly higher in PBM isolated from patients with IgA nephropathy (IgAN) and membranous nephropathy (MN) compared with normal controls.	pbm	90-93	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
7558620-3	1995	Transcapillary diffusion of intravenously injected sodium fluorescein (NaF) was quantitated by videodensitometry in terms of fluorescent light intensities (FLIs) 5, 10, 20, 30, 60, 120, 180 and 300 s after the first appearance of the dye.	Fluorescein	51-69	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
7559262-3	1995	Procaterol inhibited IL-8- and C5a-induced basophil migration in a dose-dependent fashion; 10(-7) M of procaterol reduced 30% of migration induced by both factors.	Procaterol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
7559262-3	1995	Procaterol inhibited IL-8- and C5a-induced basophil migration in a dose-dependent fashion; 10(-7) M of procaterol reduced 30% of migration induced by both factors.	Procaterol	103-113	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
8562581-2	1995	In the intact cell, NaF +/- aluminum was shown to activate various signal transduction pathways and indirect evidence is in line with effector mechanisms involving regulation of G-protein activity.	Aluminum	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	20-23
8562581-4	1995	NaF was shown to reduce intracellular ATP levels and to suppress agonist-induced protein tyrosine phosphorylation and reactive oxygen species formation.	Adenosine Triphosphate	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8562581-4	1995	NaF was shown to reduce intracellular ATP levels and to suppress agonist-induced protein tyrosine phosphorylation and reactive oxygen species formation.	Tyrosine	89-97	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8562581-4	1995	NaF was shown to reduce intracellular ATP levels and to suppress agonist-induced protein tyrosine phosphorylation and reactive oxygen species formation.	Reactive Oxygen Species	118-141	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8562581-5	1995	NaF led to in situ activation of nitrogen activated protein kinase, phospholipase A2 and PtdIns-phospholipase C. Addition of AlCl(3) or deferoxamine, a chelator of aluminum, had little or no effect on NaF mediated enzyme activation.	Aluminum Chloride	125-132	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8562581-5	1995	NaF led to in situ activation of nitrogen activated protein kinase, phospholipase A2 and PtdIns-phospholipase C. Addition of AlCl(3) or deferoxamine, a chelator of aluminum, had little or no effect on NaF mediated enzyme activation.	Deferoxamine	136-148	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8562581-5	1995	NaF led to in situ activation of nitrogen activated protein kinase, phospholipase A2 and PtdIns-phospholipase C. Addition of AlCl(3) or deferoxamine, a chelator of aluminum, had little or no effect on NaF mediated enzyme activation.	Deferoxamine	136-148	C-X-C motif chemokine ligand 8	Homo sapiens	201-204
8562581-5	1995	NaF led to in situ activation of nitrogen activated protein kinase, phospholipase A2 and PtdIns-phospholipase C. Addition of AlCl(3) or deferoxamine, a chelator of aluminum, had little or no effect on NaF mediated enzyme activation.	Aluminum	164-172	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8562581-6	1995	The results suggest that at least some of the pleiotropic effects of NaF in intact cells may not be mediated by G-protein activation but rather by depletion of ATP which is essential for protein phosphorylation reactions.	Adenosine Triphosphate	160-163	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
7837814-0	1995	Functional properties of HL60 cells matured with all-trans-retinoic acid and DMSO: differences in response to interleukin-8 and fMLP.	Tretinoin	49-72	C-X-C motif chemokine ligand 8	Homo sapiens	110-123
7699821-4	1995	IL-8 increased significantly after the start of CPB and reached a peak at 10 minutes after release of the aortic cross-clamp, remaining significantly elevated until 10 minutes after the end of CPB (P &lt; 0.05).	cpb	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
7837814-9	1995	Cells matured with DMSO responded to both IL-8 and fMLP in an equal manner with 1.6-fold increases in F-actin.	Dimethyl Sulfoxide	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
7837814-10	1995	The 2 h migration for ATRA induced cells was 124 microns in response to IL-8, 107 microns with fMLP, and 105 microns in buffer.	Tretinoin	22-26	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
7837814-11	1995	DMSO induced cells migrated 89 microns in response to IL-8, 106 microns with fMLP, and 66 microns in buffer.	Dimethyl Sulfoxide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
7837814-13	1995	In summary, HL60 cells cultured in ATRA develop greater functional maturity than those cultured in DMSO, and a greater responsiveness to IL-8 than fMLP, a finding distinct from previously reported work in neutrophils.	Tretinoin	35-39	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
7699821-4	1995	IL-8 increased significantly after the start of CPB and reached a peak at 10 minutes after release of the aortic cross-clamp, remaining significantly elevated until 10 minutes after the end of CPB (P &lt; 0.05).	cpb	193-196	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
7699821-7	1995	This study demonstrates elevated TNF alpha and IL-8 levels during CPB followed by increases of the neutrophil and the granulocyte elastase, which may be of importance in the systemic inflammatory response to CPB, especially in the development of postperfusion lung injury.	cpb	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
22827272-6	1995	IL-8 production by TCC from the ocular fluid was further up-regulated upon stimulatation with PHA, but was suppressed by FK506 and hydrocortisone, though not by diclofenac sodium.	Tacrolimus	121-126	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
7770008-1	1995	AlCl3, BeCl2 and NaF do not influence the insulin binding of Tetrahymena immediately after treatment, but 24 h later insulin binding is decreased or increased by NaF in a dose-dependent manner, AlCl3 barely influences the binding, and BeCl2 increases it.	Aluminum Chloride	194-199	C-X-C motif chemokine ligand 8	Homo sapiens	162-165
7476567-1	1995	Previous findings provided evidence that bacterial lipopolysaccharide (LPS)-activated human monocytes are able to upregulate autologous polymorphonuclear (PMN) phagocytic ability via cell-to-cell contact mechanisms mediated by membrane (m)-associated cytokines (CKs), such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-1 alpha, IL-1 beta, IL-6 and IL-8.	bacterial lipopolysaccharide	41-69	C-X-C motif chemokine ligand 8	Homo sapiens	358-362
8587625-3	1995	A significant increase in GBM 35sulfate uptake was only seen when the glomeruli were cultured with the addition of IL-8 as compared with control cultures: 10.8 +/- (SEM) 1.7 and 7.9 +/- 1.4 cpm/micrograms GBM protein, respectively (p &lt; 0.005).	35sulfate	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
8587625-4	1995	IL-8 reproduces the effect of the reported supernatant factor on the GBM 35sulfate uptake.	35sulfate	73-82	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8587625-5	1995	Because IL-8 was detected in the supernatant of peripheral mononuclear cell cultures from idiopathic minimal-lesion nephrotic syndrome patients in relapse and because the increased GBM 35sulfate incorporation induced by the supernatant factor has been abolished by the addition to the culture media of anti-IL-8 neutralizing antibodies, we postulate that IL-8 is the previously described supernatant factor.	35sulfate	185-194	C-X-C motif chemokine ligand 8	Homo sapiens	8-12
22827272-6	1995	IL-8 production by TCC from the ocular fluid was further up-regulated upon stimulatation with PHA, but was suppressed by FK506 and hydrocortisone, though not by diclofenac sodium.	Hydrocortisone	131-145	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
22827272-6	1995	IL-8 production by TCC from the ocular fluid was further up-regulated upon stimulatation with PHA, but was suppressed by FK506 and hydrocortisone, though not by diclofenac sodium.	Diclofenac	161-178	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
22827272-7	1995	Colchicine rather increased IL-8 production by these TCC.	Colchicine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
7571853-18	1995	EM and Roxythromycin, suppressed IL-8 production in Pseudomonas-stimulated neutrophils in a dose-dependent manner.	Erythromycin	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
7571853-18	1995	EM and Roxythromycin, suppressed IL-8 production in Pseudomonas-stimulated neutrophils in a dose-dependent manner.	roxythromycin	7-20	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
7571853-19	1995	1 alpha, 25-dihydroxy vitamin D3 also inhibited neutrophil-derived IL-8.	Calcitriol	0-32	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
7502507-4	1995	Liberation of cytokines (IL-1, IL-6, IL-8) stimulates prostanoid synthesis in the decidua and amnion, as well as migration of granulocytes into the cervix.	Prostaglandins	54-64	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
7828901-2	1994	The cDNA encodes a predicted sequence of 114 amino acids and contains the Cys motif C-X-C found in other members of the alpha-chemokine family which also includes interleukin 8 (IL-8).	Cysteine	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	163-176
7806518-4	1994	While the basic fold is similar to that seen for interleukin-8 (IL-8) (Clore, G. M., Appella, E., Yamada, M., Matsushima, K., and Gronenborn, A. M. (1990) Biochemistry, 29, 1689-1696), there are differences in the ELR motif (residues 6-8), the turn involving residues 31-36, which is linked to the NH2-terminal region through the 9-35 disulfide bond.	Disulfides	335-344	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
7828901-2	1994	The cDNA encodes a predicted sequence of 114 amino acids and contains the Cys motif C-X-C found in other members of the alpha-chemokine family which also includes interleukin 8 (IL-8).	Cysteine	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
7821808-1	1994	The nucleotide (nt) sequence encoding the ovine homologue of interleukin-8 (IL-8) was determined.	Nucleotides	16-18	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
7527448-5	1994	These IL-8R-B-specific mAbs were able to inhibit up to 90 and 50% of the 125I-labeled IL-8 binding to 293-27 cells and human neutrophils, respectively.	Iodine-125	73-77	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
7821808-1	1994	The nucleotide (nt) sequence encoding the ovine homologue of interleukin-8 (IL-8) was determined.	Nucleotides	16-18	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
7524649-6	1994	DHA also limited cytokine-stimulated endothelial cell expression of E-selectin and intercellular adhesion molecule 1 and the secretion of IL-6 and IL-8 into the medium but not the surface expression of constitutive surface molecules.	Docosahexaenoic Acids	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
7949145-7	1994	Inhibition of PA formation, by the presence of ethanol, also inhibited the oxidative burst stimulation by IL-8.	Phosphatidic Acids	14-16	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
7949145-7	1994	Inhibition of PA formation, by the presence of ethanol, also inhibited the oxidative burst stimulation by IL-8.	Ethanol	47-54	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
7949145-9	1994	Collectively, these data show that IL-8 stimulates the metabolism of choline-containing phosphoglycerides in human PMN and support a role for PA in the signaling mechanisms used by IL-8 to stimulate PMN function.	Choline	69-76	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
7949145-9	1994	Collectively, these data show that IL-8 stimulates the metabolism of choline-containing phosphoglycerides in human PMN and support a role for PA in the signaling mechanisms used by IL-8 to stimulate PMN function.	Glycerophospholipids	88-105	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
7949145-9	1994	Collectively, these data show that IL-8 stimulates the metabolism of choline-containing phosphoglycerides in human PMN and support a role for PA in the signaling mechanisms used by IL-8 to stimulate PMN function.	Phosphatidic Acids	142-144	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
7949145-9	1994	Collectively, these data show that IL-8 stimulates the metabolism of choline-containing phosphoglycerides in human PMN and support a role for PA in the signaling mechanisms used by IL-8 to stimulate PMN function.	Phosphatidic Acids	142-144	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
7988196-16	1994	CONCLUSIONS: We conclude that asthmatics exposed to ozone develop a significant BALF neutrophilia and increased levels of the cytokines, IL-8 and IL-6.	Ozone	52-57	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
7798535-7	1994	Treatment with inhaled beclomethasone dipropionate 500 micrograms twice a day led to a significant decrease in both the expression of GM-CSF (p &lt; 0.01) and IL-8 (p &lt; 0.02) and the number of EG2-staining cells (p &lt; 0.01) in the epithelium.	Beclomethasone	23-50	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
7798535-10	1994	Also, beclomethasone dipropionate may inhibit eosinophil activation partly by downregulating the expression of GM-CSF and IL-8 in the bronchial epithelium.	Beclomethasone	6-33	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
7875261-5	1994	We also determined the local effect of intratracheal administration of leumedin NPC 15669, an inhibitor of neutrophil recruitment, on IL-8- and Pseudomonas-induced neutrophil accumulation.	Leumedin	71-79	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
7858873-14	1994	NaF (20 mM) and thrombin (EC50 0.4 u ml-1) also induced inositol phosphate formation in HUVEC.	Inositol Phosphates	56-74	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
7525815-4	1994	On the other hand, an immunosuppressant, FK506, and a glucocorticoid inhibit the gene transcription as well as the production of IL-8.	Tacrolimus	41-46	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
7525817-5	1994	For example, treatments of neutrophils with interleukin-8 (IL-8) or granulocyte colony-stimulating factor (G-CSF) potentiated the P-selectin-induced O2- production.	Superoxides	149-151	C-X-C motif chemokine ligand 8	Homo sapiens	44-57
7525817-5	1994	For example, treatments of neutrophils with interleukin-8 (IL-8) or granulocyte colony-stimulating factor (G-CSF) potentiated the P-selectin-induced O2- production.	Superoxides	149-151	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
7754458-3	1994	Fluoride gel (1.1% NaF) was applied to the facial tooth surfaces of 10 elderly nursing home residents using a sponge-type intraoral applicator (IA).	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
7927762-5	1994	Preincubation of the cells with the protein tyrosine kinase inhibitors lavendustin A and tyrphostin 25 led to a reduction of the toxin-mediated effects on IL-8 release and IL-8 mRNA expression when Luk-PV and Alv were used as stimuli.	lavendustin A	71-84	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
7927762-5	1994	Preincubation of the cells with the protein tyrosine kinase inhibitors lavendustin A and tyrphostin 25 led to a reduction of the toxin-mediated effects on IL-8 release and IL-8 mRNA expression when Luk-PV and Alv were used as stimuli.	lavendustin A	71-84	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
7927762-5	1994	Preincubation of the cells with the protein tyrosine kinase inhibitors lavendustin A and tyrphostin 25 led to a reduction of the toxin-mediated effects on IL-8 release and IL-8 mRNA expression when Luk-PV and Alv were used as stimuli.	Tyrphostins	89-99	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
7927762-5	1994	Preincubation of the cells with the protein tyrosine kinase inhibitors lavendustin A and tyrphostin 25 led to a reduction of the toxin-mediated effects on IL-8 release and IL-8 mRNA expression when Luk-PV and Alv were used as stimuli.	Tyrphostins	89-99	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
7927772-5	1994	PMBC elicited large amounts of these cytokines, as well as IL-8 and TNF-beta, with an optimal release after 48 to 96 h. The most abundant cytokine produced in response to ETA was IL-8.	pmbc	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
7927772-5	1994	PMBC elicited large amounts of these cytokines, as well as IL-8 and TNF-beta, with an optimal release after 48 to 96 h. The most abundant cytokine produced in response to ETA was IL-8.	pmbc	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
7930619-4	1994	In this study, we demonstrate that adenosine inhibits the production of TNF-alpha, IL-6, and IL-8 by LPS-activated human monocytes with a differential potency.	Adenosine	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
7930619-8	1994	In contrast, adenosine enhanced production of IL-6 and IL-8 by monocytes stimulated with IL-1 beta.	Adenosine	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
7930619-9	1994	Furthermore, only 2-chloroadenosine, but not NECA, strongly inhibited cytokine-induced IL-6 and IL-8 production.	2-Chloroadenosine	18-35	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
7853122-9	1994	These results indicate that IL-8 production by HGF is synergistically stimulated by specific cytokines, IL-1 beta and TNF-alpha, and suggest that these stimulatory effects are down-regulated by IFN-gamma at the transcriptional level through PGE2-independent pathways.	Dinoprostone	241-245	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
7943343-2	1994	TNF-alpha increased IL-8 mRNA and protein expression in HAEC in a concentration- and time-dependent manner and these effects were inhibited by dexamethasone (1 microM).	Dexamethasone	143-156	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
7943343-5	1994	A549 cells also increased IL-8 secretion and mRNA after incubation of TNF-alpha, with inhibition by dexamethasone.	Dexamethasone	100-113	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
7943343-4	1994	TNF-alpha-induced IL-8 mRNA expression showed a biphasic response in HAEC, with an early increase at 2 h followed by a sustained increase from 8 h, which was abolished by the addition of cycloheximide, suggesting that the synthesis of another protein was involved.	Cycloheximide	187-200	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
7919340-0	1994	Histamine induces interleukin-8 secretion by endothelial cells.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
7919340-4	1994	The results showed that histamine increased the secretion and the mRNA expression of IL-8 by EC.	Histamine	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
7919350-2	1994	Previous studies with the chemokine interleukin-8 (IL-8) had shown that the N-terminal region preceding the first cysteine residue was critical in defining neutrophil-activating properties.	Cysteine	114-122	C-X-C motif chemokine ligand 8	Homo sapiens	36-49
7919340-5	1994	Histamine-induced IL-8 production was (1) dose-dependent (at a dose &gt; or = 10(-6) mol/L), (2) potentialized by costimulation with tumor necrosis factor (TNF)-alpha, (3) inhibited by H1 or H2 histamine receptor antagonists, and (4) significantly increased 4 hours after the initial stimulation.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
7919350-2	1994	Previous studies with the chemokine interleukin-8 (IL-8) had shown that the N-terminal region preceding the first cysteine residue was critical in defining neutrophil-activating properties.	Cysteine	114-122	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
7919340-6	1994	These data suggest that histamine may be involved in the control of the late inflammatory reaction associated to allergic disorders through IL-8 secretion by EC.	Histamine	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
7925583-0	1994	Staurosporine restores signaling and inhibits interleukin-8-induced chemotactic desensitization.	Staurosporine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	46-59
7925583-5	1994	Using two-dimensional analysis we have shown that IL-8 induced a rapid serine/threonine phosphorylation of a number of neutrophil substrates the most prominent being phosphoprotein 39 (pp39), extracellular signal-related kinase-1, pp55 and pp66.	Serine	71-77	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
7835945-0	1994	Pentoxifylline in vivo down-regulates the release of IL-1 beta, IL-6, IL-8 and tumour necrosis factor-alpha by human peripheral blood mononuclear cells.	Pentoxifylline	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
7925583-5	1994	Using two-dimensional analysis we have shown that IL-8 induced a rapid serine/threonine phosphorylation of a number of neutrophil substrates the most prominent being phosphoprotein 39 (pp39), extracellular signal-related kinase-1, pp55 and pp66.	Threonine	78-87	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
7925583-8	1994	When neutrophils were pretreated with staurosporine, prior to desensitization, phosphorylation of pp39 was observed upon restimulation with IL-8.	Staurosporine	38-51	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
7925583-10	1994	Thus, homologous desensitization of neutrophils in response to IL-8 does not result from changes in receptor expression, but rather from a staurosporine-sensitive inactivation of subsequent signal transduction.	Staurosporine	139-152	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
7835984-4	1994	By analogy with the most prevalent form of hIL-8, a 72 amino acid form of oIL-8 was expressed as a fusion protein containing glutathione-S-transferase and purified by affinity chromatography on a glutathione-Sepharose column yielding 8 mg IL-8/L broth culture.	Oils	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	43-48
7835984-4	1994	By analogy with the most prevalent form of hIL-8, a 72 amino acid form of oIL-8 was expressed as a fusion protein containing glutathione-S-transferase and purified by affinity chromatography on a glutathione-Sepharose column yielding 8 mg IL-8/L broth culture.	Oils	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
7835945-3	1994	Due to the therapeutic implications, the present study addressed the in vivo effects of PTX on the release of TNF-alpha, IL-1 beta, IL-6 and IL-8 by human peripheral blood mononuclear cells (PBMC).	Pentoxifylline	88-91	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
7835945-4	1994	When PBMC were obtained from healthy volunteers ingesting 5 x 400 mg PTX orally for 2 days, the ability of PBMC cultured for 24 hr to release TNF-alpha was significantly reduced, while secretion of IL-1 beta, IL-6 and IL-8 was not affected.	Pentoxifylline	69-72	C-X-C motif chemokine ligand 8	Homo sapiens	218-222
7835945-9	1994	However, when PBMC were incubated with PTX for 24 hr, PTX removed thereafter by medium change and cells further cultured, the production not only of TNF-alpha but also of IL-1 beta, IL-6 and IL-8 was reduced, demonstrating that PTX exerts diverse (inhibitory) effects on cytokine release by PBMC.	Pentoxifylline	39-42	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
7835945-9	1994	However, when PBMC were incubated with PTX for 24 hr, PTX removed thereafter by medium change and cells further cultured, the production not only of TNF-alpha but also of IL-1 beta, IL-6 and IL-8 was reduced, demonstrating that PTX exerts diverse (inhibitory) effects on cytokine release by PBMC.	Pentoxifylline	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
7835945-9	1994	However, when PBMC were incubated with PTX for 24 hr, PTX removed thereafter by medium change and cells further cultured, the production not only of TNF-alpha but also of IL-1 beta, IL-6 and IL-8 was reduced, demonstrating that PTX exerts diverse (inhibitory) effects on cytokine release by PBMC.	Pentoxifylline	54-57	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
7853361-1	1994	A light addressable potentiometric sensor was used to measure acetylcholinesterase (AChE) activity in order to evaluate the protective effects of quaternary compounds and NaF against enzyme phosphorylation and aging by two organophosphates.	Organophosphates	223-239	C-X-C motif chemokine ligand 8	Homo sapiens	171-174
7927669-0	1994	Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases.	Erythromycin	57-69	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
7927669-5	1994	When anti-human IL-8 immunoglobulin G was used for neutralizing neutrophil chemotactic factor (NCF) activities in BAL fluids, the mean reduction rate of NCF activities in CAD+PA patients was significantly higher than that in CAD-PA patients.	cad+pa	171-177	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
7927669-5	1994	When anti-human IL-8 immunoglobulin G was used for neutralizing neutrophil chemotactic factor (NCF) activities in BAL fluids, the mean reduction rate of NCF activities in CAD+PA patients was significantly higher than that in CAD-PA patients.	cad-pa	225-231	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
7927669-7	1994	Treatment with erythromycin caused significant reductions of neutrophil numbers, IL-8/albumin ratios, and NE/albumin ratios in BAL fluids from these patients.	Erythromycin	15-27	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
7927669-8	1994	To elucidate the mechanism of erythromycin therapy, we also examined whether erythromycin suppressed IL-8 production by human alveolar macrophages and neutrophils in vitro.	Erythromycin	77-89	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
7927669-9	1994	We demonstrated a moderate inhibitory effect of erythromycin on IL-8 production in Pseudomonas-stimulated neutrophils but not in alveolar macrophages.	Erythromycin	48-60	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
7853361-4	1994	Sodium fluoride (NaF), the most effective protectant against phosphorylation and aging, and the quaternary ammonium compounds reduced significantly AChE inhibition by DFP and paraoxon, to similar degrees.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
7927669-11	1994	The clinical efficacy of erythromycin therapy for CAD patients might be partly mediated through a reduced IL-8 production, diminishing neutrophil accumulation and NE release in the airways.	Erythromycin	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
7962609-6	1994	H pylori induced IL-8 secretion was reduced by heat killing, sonication, freeze thawing or formalin fixation of the bacteria.	Formaldehyde	91-99	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
7947352-5	1994	Specifically, RU486 (at concentrations of 1-100 nM) exerts pure antagonist actions by almost completely reversing the inhibitory effects of the glucocorticoid dexamethasone (Dex) on the release of monocyte/macrophages-derived lymphokines, such as IL-1, IL-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha).	Mifepristone	14-19	C-X-C motif chemokine ligand 8	Homo sapiens	259-263
7930675-5	1994	As such, auranofin was also studied for its effect on IL-8 production.	Auranofin	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
7930675-6	1994	Auranofin and staurosporine, inhibitors of protein kinase C, inhibited phorbol-myristate-acetate-stimulated IL-8 production.	Auranofin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
7930675-6	1994	Auranofin and staurosporine, inhibitors of protein kinase C, inhibited phorbol-myristate-acetate-stimulated IL-8 production.	Staurosporine	14-27	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
7930675-6	1994	Auranofin and staurosporine, inhibitors of protein kinase C, inhibited phorbol-myristate-acetate-stimulated IL-8 production.	Tetradecanoylphorbol Acetate	71-96	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
8089496-0	1994	Asbestos stimulates IL-8 production from human lung epithelial cells.	Asbestos	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
8089496-4	1994	That the membrane signaling events responsible for asbestos-induced IL-8 production are distinct from those responsible for IL-8 induction by cytokines was confirmed by using membrane-stabilizing agents and protein synthesis inhibitors.	Asbestos	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
8089498-6	1994	In the presence of cytochalasin B, only fMLP and C5a caused the activation of phospholipase D in intact leukocytes and enhanced desensitization of IL-8 and C5a but not fMLP receptors.	Cytochalasin B	19-33	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
7523800-0	1994	Modulation of IL-8, IL-1 beta, and G-CSF secretion by all-trans retinoic acid in acute promyelocytic leukemia.	Tretinoin	64-77	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
7947352-5	1994	Specifically, RU486 (at concentrations of 1-100 nM) exerts pure antagonist actions by almost completely reversing the inhibitory effects of the glucocorticoid dexamethasone (Dex) on the release of monocyte/macrophages-derived lymphokines, such as IL-1, IL-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha).	Dexamethasone	159-172	C-X-C motif chemokine ligand 8	Homo sapiens	259-263
7947352-5	1994	Specifically, RU486 (at concentrations of 1-100 nM) exerts pure antagonist actions by almost completely reversing the inhibitory effects of the glucocorticoid dexamethasone (Dex) on the release of monocyte/macrophages-derived lymphokines, such as IL-1, IL-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha).	Dexamethasone	174-177	C-X-C motif chemokine ligand 8	Homo sapiens	259-263
7947352-6	1994	Dex decreased in a dose-dependent manner the release of the above four lymphokines, with an ID50 of 0.9 +/- 0.1, 4.76 +/- 0.4, 9.8 +/- 1.8, and 1.16 +/- 0.2 nM for IL-1, IL-6, IL-8 and TNF-alpha, respectively.	Dexamethasone	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
8077662-5	1994	Furthermore, cyclosporin A, but not rapamycin, blocked the synergistic induction of IL-8 expression achieved with anti-CD3 and anti-CD28 costimulation.	Cyclosporine	13-26	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
8069926-4	1994	In this report, we show that the IFN-gamma-dependent inhibition of IL-8 release by PMN stimulated with lipopolysaccharide (LPS), tumor necrosis factor (TNF), and/or interleukin-1 beta (IL-1 beta), but not with Y-IgG, is a transient phenomenon.	y-igg	210-215	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
8083528-9	1994	Monocytes or monocyte tumor cells produce MCP-1 and/or IL-8 in response to cytokines, virus, double stranded RNA, bacterial endotoxin, mitogen or phorbol ester.	Phorbol Esters	146-159	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
7972371-3	1994	The association constant of NaF with AlPcSn in aqueous solution was measured as 500 +/- 20 M-1.	alpcsn	37-43	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
8090031-2	1994	Monocytes express the esterase isoenzyme (termed "monocyte-specific esterase", MSE) that can be inhibited by NaF in the alpha-naphthyl acetate cytochemical staining.	alpha-naphthyl acetate	120-142	C-X-C motif chemokine ligand 8	Homo sapiens	109-112
7962965-5	1994	Etretinate was shown to have an effect on either IL-1 alpha or IL-8 secretion in unstimulated NHKs.	Etretinate	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
7962965-6	1994	In HSC-1, a human squamous cell carcinoma cell line cultured in 20% FCS/DMEM, inhibited IL-1 alpha secretion and enhanced IL-8 secretion.	dmem	72-76	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
7962965-8	1994	Stimulation of NHKs with PMA significantly enhanced IL-1 alpha and IL-8 secretion, and these effects were inhibited by etretinate.	Etretinate	119-129	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
8074242-0	1994	Hyperoxia stimulates interleukin-8 release from alveolar macrophages and U937 cells: attenuation by dexamethasone.	Dexamethasone	100-113	C-X-C motif chemokine ligand 8	Homo sapiens	21-34
8062926-4	1994	Sulfatides enhanced expression of tumor necrosis factor, interleukin-8, and interleukin-1 beta, but not interleukin-12/natural killer cell stimulating factor mRNAs.	Sulfoglycosphingolipids	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	57-70
8074242-9	1994	Finally, dexamethasone at concentrations of 10 microM, 1 microM, and 100 nM markedly reduced hyperoxia-induced IL-8 release and mRNA synthesis by U937 cells.	Dexamethasone	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
8074242-10	1994	We conclude that IL-8 may be important in the pathogenesis of pulmonary oxygen toxicity and that therapeutic concentrations of dexamethasone can suppress production of this cytokine.	Oxygen	72-78	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
7989497-8	1994	The perivascular location of IL-8 throughout the stages of the human menstrual cycle is consistent with its proposed biological role as a modulator of endometrial function, especially synergism with prostaglandin E and the transmigration of leukocytes.	Prostaglandins E	199-214	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
8034699-3	1994	We then analyzed these receptor mutants for their ability to mobilize intracellular calcium upon stimulation with 10 nM IL-8.	Calcium	84-91	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
7972306-8	1994	Application of NaF (20 mM) for 4 min as a rinse significantly enhanced all of the sweet compounds by at least 23%, except for 10 mM sodium saccharin and 6.5 mM D-tryptophan, while all control compounds were suppressed.	Saccharin	132-148	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
7972306-8	1994	Application of NaF (20 mM) for 4 min as a rinse significantly enhanced all of the sweet compounds by at least 23%, except for 10 mM sodium saccharin and 6.5 mM D-tryptophan, while all control compounds were suppressed.	D-Tryptophan	160-172	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
8034626-6	1994	No effects of the Rap1A mutants on cell viability, proliferation, expression of cell-surface markers, or phorbol 12-myristate 13-acetate-stimulated interleukin-8 generation were detected.	Tetradecanoylphorbol Acetate	105-136	C-X-C motif chemokine ligand 8	Homo sapiens	148-161
7967357-5	1994	Elevated urinary IL-8 levels during the acute phase or exacerbations were found to be decreased during spontaneous or steroid pulse therapy-induced convalescence in all patients examined.	Steroids	118-125	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
8034699-6	1994	Our study shows that, besides the extracellular domain cysteines which may be critical for the overall folding of the receptor, three residues, Arg-199, Arg-203, and Asp-265, are important for IL-8 binding and IL-8-mediated signal transduction.	Arginine	144-147	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
8034699-6	1994	Our study shows that, besides the extracellular domain cysteines which may be critical for the overall folding of the receptor, three residues, Arg-199, Arg-203, and Asp-265, are important for IL-8 binding and IL-8-mediated signal transduction.	Arginine	144-147	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
8034699-6	1994	Our study shows that, besides the extracellular domain cysteines which may be critical for the overall folding of the receptor, three residues, Arg-199, Arg-203, and Asp-265, are important for IL-8 binding and IL-8-mediated signal transduction.	Arginine	153-156	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
8034699-6	1994	Our study shows that, besides the extracellular domain cysteines which may be critical for the overall folding of the receptor, three residues, Arg-199, Arg-203, and Asp-265, are important for IL-8 binding and IL-8-mediated signal transduction.	Aspartic Acid	166-169	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
8034699-6	1994	Our study shows that, besides the extracellular domain cysteines which may be critical for the overall folding of the receptor, three residues, Arg-199, Arg-203, and Asp-265, are important for IL-8 binding and IL-8-mediated signal transduction.	Aspartic Acid	166-169	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
7976312-1	1994	Interleukin-8 induces chemotaxis of neutrophils, basophils and T-lymphocytes, releases intracellular enzymes from neutrophils and histamine from basophils, and regulates the adhesion of neutrophils.	Histamine	130-139	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
7865076-5	1994	Significantly more fluoride was found in plaque from subjects who were using the NaF dentifrices than in plaque from subjects who were using Na2FPO3 dentifrices of the same F content.	Fluorides	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
7519403-8	1994	Dexamethasone also inhibited the induction of IL-6 and IL-8 RNA by IL-1 and TNF.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
7519401-6	1994	Cheek cells exhibited a low endogenous rate of oxygen consumption, which was stimulated by glucose or succinate and inhibited by KCN or NaF.	Oxygen	47-53	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
7519403-3	1994	Dexamethasone blocks the induction of IL-6 and IL-8 by IL-1 or TNF.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
7519403-4	1994	In these studies, we determined whether dexamethasone interferes with the upregulation of IL-6 and IL-8 by downregulating expression of the IL-1 or TNF receptor genes.	Dexamethasone	40-53	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
8089604-24	1994	Thrombin, LPS, interleukin-8 and ET-1, known calcium agonists could increase intracellular calcium in fibroblasts, amnion and uterine myocytes.	Calcium	45-52	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
8089604-24	1994	Thrombin, LPS, interleukin-8 and ET-1, known calcium agonists could increase intracellular calcium in fibroblasts, amnion and uterine myocytes.	Calcium	91-98	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
7517209-6	1994	In addition, supernatants of purified B-CLL cells cultured in the presence of 12-O-tetradecanoylphorbol-13-acetate showed chemotactic activity towards neutrophils; this activity was neutralized in the presence of an anti-IL-8 antiserum.	Tetradecanoylphorbol Acetate	78-114	C-X-C motif chemokine ligand 8	Homo sapiens	221-225
7922784-0	1994	Dexamethasone regulates IL-1 beta and TNF-alpha-induced interleukin-8 production in human bone marrow stromal and osteoblast-like cells.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
7922784-1	1994	We have investigated both constitutive- and cytokine-induced secretion of interleukin-8 (IL-8) and its regulation by dexamethasone and 17 beta-estradiol in normal human bone marrow stromal (HBMS), osteoblast-like cells (hOB), and osteosarcoma MG-63 cells.	Estradiol	135-152	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
7922784-6	1994	Dexamethasone (10(-7) M) significantly inhibited IL-1 beta plus TNF-alpha stimulated IL-8 production in HBMS, MG-63, and hOB cells.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
7818993-3	1994	AFC-ME, but not AFC, inhibited NaF- and PMA-stimulated superoxide release.	afc-me	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
8003341-0	1994	Leukotriene B4 stimulates human polymorphonuclear leukocytes to synthesize and release interleukin-8 in vitro.	Leukotriene B4	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	87-100
7818993-3	1994	AFC-ME, but not AFC, inhibited NaF- and PMA-stimulated superoxide release.	N-acetyl-S-farnesylcysteine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
7818993-3	1994	AFC-ME, but not AFC, inhibited NaF- and PMA-stimulated superoxide release.	Superoxides	55-65	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
7948754-0	1994	Measurement of cell migration stimulated by interleukin 8: use of ATP chemiluminescence.	Adenosine Triphosphate	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	44-57
7525460-0	1994	Interleukin-8 and RANTES induce the adhesion of the human basophilic cell line KU-812 to human endothelial cell monolayers.	ku-812	79-85	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
8088360-3	1994	Cyclosporine, calcitriol, calcipotriol or dithranol caused a dose-dependent decrease in interleukin-8 binding to cultured human keratinocytes, while interleukin-8 binding to granulocytes was not affected.	Cyclosporine	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
8088360-3	1994	Cyclosporine, calcitriol, calcipotriol or dithranol caused a dose-dependent decrease in interleukin-8 binding to cultured human keratinocytes, while interleukin-8 binding to granulocytes was not affected.	Cyclosporine	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	149-162
8088360-3	1994	Cyclosporine, calcitriol, calcipotriol or dithranol caused a dose-dependent decrease in interleukin-8 binding to cultured human keratinocytes, while interleukin-8 binding to granulocytes was not affected.	Calcitriol	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
8088360-3	1994	Cyclosporine, calcitriol, calcipotriol or dithranol caused a dose-dependent decrease in interleukin-8 binding to cultured human keratinocytes, while interleukin-8 binding to granulocytes was not affected.	Calcitriol	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	149-162
8088360-3	1994	Cyclosporine, calcitriol, calcipotriol or dithranol caused a dose-dependent decrease in interleukin-8 binding to cultured human keratinocytes, while interleukin-8 binding to granulocytes was not affected.	calcipotriene	26-38	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
8088360-3	1994	Cyclosporine, calcitriol, calcipotriol or dithranol caused a dose-dependent decrease in interleukin-8 binding to cultured human keratinocytes, while interleukin-8 binding to granulocytes was not affected.	calcipotriene	26-38	C-X-C motif chemokine ligand 8	Homo sapiens	149-162
8088360-3	1994	Cyclosporine, calcitriol, calcipotriol or dithranol caused a dose-dependent decrease in interleukin-8 binding to cultured human keratinocytes, while interleukin-8 binding to granulocytes was not affected.	Anthralin	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	88-101
8088360-3	1994	Cyclosporine, calcitriol, calcipotriol or dithranol caused a dose-dependent decrease in interleukin-8 binding to cultured human keratinocytes, while interleukin-8 binding to granulocytes was not affected.	Anthralin	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	149-162
8013067-6	1994	In addition, IL-8 stimulated smooth muscle cells to produce prostaglandin E2, which can inhibit IL-8-induced smooth muscle cell proliferation.	Dinoprostone	60-76	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
8013067-6	1994	In addition, IL-8 stimulated smooth muscle cells to produce prostaglandin E2, which can inhibit IL-8-induced smooth muscle cell proliferation.	Dinoprostone	60-76	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
8013067-7	1994	In the presence of indomethacin (5 mumol/L), IL-8 (1 nmol/L) stimulated an increase in human and rat aortic smooth muscle cell number during a 3-day period of incubation by 61 +/- 16% and 59 +/- 7% (n = 4), respectively.	Indomethacin	19-31	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
8013067-9	1994	Moreover, IL-8 stimulated rat aortic smooth muscle cell migration by 20-fold over the control value, with an EC50 value of 0.83 nmol/L; this chemotactic activity of IL-8 was also potentiated by indomethacin.	Indomethacin	194-206	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
8013067-9	1994	Moreover, IL-8 stimulated rat aortic smooth muscle cell migration by 20-fold over the control value, with an EC50 value of 0.83 nmol/L; this chemotactic activity of IL-8 was also potentiated by indomethacin.	Indomethacin	194-206	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
8027219-2	1994	We study here the regulation of the PiP2 cascade by TSH, ATP, NaF, and bradykinin.	Phosphatidylinositol 4,5-Diphosphate	36-40	C-X-C motif chemokine ligand 8	Homo sapiens	62-65
8027219-4	1994	Activation of the PiP2 cascade by TSH (10 mU/mL), NaF, bradykinin, ionomycin, and 12-O-tetradecanoylphorbol-13-acetate stimulates iodide organification.	Phosphatidylinositol 4,5-Diphosphate	18-22	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
7912755-10	1994	Culture supernatants from blasts cultured with or without TPA showed the production of large amounts of IL-8, IL-6, TNF-alpha, MIP-1 alpha, IL-10 and interferon gamma and modest amounts of IL-1 alpha, GM-CSF and stem cell factor.	Tetradecanoylphorbol Acetate	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
8003341-2	1994	Here we examine whether PMN synthesize and release IL-8 in response to stimulation by leukotriene B4 (LTB4).	Leukotriene B4	86-100	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
8003341-10	1994	Northern blot analysis of total RNA from PMN using a 30 mer oligonucleotide for IL-8 demonstrated increased mRNA expression in LTB4-stimulated PMN compared with untreated PMN.	Oligonucleotides	60-75	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
8004813-4	1994	In contrast, IL-10 was weakly expressed when fibroblasts were stimulated with LPS, IL-1 alpha or tumour necrosis factor-alpha (TNF-alpha), but the expression was enhanced in the presence of cycloheximide combined with optimal concentrations of LPS, IL-1 alpha or TNF-alpha, IL-1 alpha was a more potent stimulator than LPS for GM-CSF, IL-6, IL-8 and IL-10 expression, but not for IL-1 alpha and IL-1 beta.	Cycloheximide	190-203	C-X-C motif chemokine ligand 8	Homo sapiens	341-345
8200045-5	1994	When the MLR was performed in the presence of NMA (500 microM), the production of IL-8 increased twofold (P &lt; 0.05) and ENA-78 increased fivefold (P &lt; 0.05), while MCP-1 and MIP-1 alpha were not significantly altered.	nma	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
8200045-6	1994	These findings suggest that NMA, an inhibitor of the L-arginine metabolic pathway, may regulate the production of specific C-X-C chemokines, IL-8 and ENA-78, during a MLR.	nma	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
8200045-6	1994	These findings suggest that NMA, an inhibitor of the L-arginine metabolic pathway, may regulate the production of specific C-X-C chemokines, IL-8 and ENA-78, during a MLR.	Arginine	53-63	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
8004813-6	1994	Dexamethasone suppressed both gene expression and protein production of GM-CSF, IL-6 and IL-8 when fibroblasts were exposed to IL-1 alpha.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
7960166-2	1994	The objective was to compare the effect of four dose levels of sodium monofluorophosphate (SMFP) and a single dose level of sodium fluoride (NaF) on DMFS, DMFT, and DFS Interproximal indices.	Sodium Fluoride	124-139	C-X-C motif chemokine ligand 8	Homo sapiens	141-144
7960166-5	1994	Results indicated that the 2000 ppm F NaF group had significantly smaller DMFS increment than the 2000 ppm F SMFP group p &lt; 0.005.	dmfs	74-78	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
7960166-6	1994	The 2000 ppm F NaF group demonstrated an 18 per cent (26 per cent for children &gt; 10 years at baseline) reduction in DMFS over the 1500 ppm F SMFP group, the 2500 ppm F group a 15 per cent (19 per cent) reduction, and the 2000 ppm F SMFP a 5 per cent (9 per cent) reduction.	dmfs	119-123	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
7514637-0	1994	Zymosan-induced IL-8 release from human neutrophils involves activation via the CD11b/CD18 receptor and endogenous platelet-activating factor as an autocrine modulator.	Zymosan	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
8188340-6	1994	Furthermore, the addition of TNF, GM-CSF, or IL-8 to whole blood increased the capacity of a subpopulation of PMN to bind N-formyl peptides, a phenomenon that could account, at least in part, for the strong H2O2 production in response to FMLP after priming by the cytokines.	n-formyl peptides	122-139	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
8188340-6	1994	Furthermore, the addition of TNF, GM-CSF, or IL-8 to whole blood increased the capacity of a subpopulation of PMN to bind N-formyl peptides, a phenomenon that could account, at least in part, for the strong H2O2 production in response to FMLP after priming by the cytokines.	Hydrogen Peroxide	207-211	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
8188340-5	1994	TNF, GM-CSF, and IL-8 strongly primed a subpopulation of PMN to produce H2O2 in response to N-formyl-methionyl-leucyl-phenylalanine (FMLP), while IL-1 alpha, IL-1 beta, and IL-6 failed to do so.	Hydrogen Peroxide	72-76	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
8188340-5	1994	TNF, GM-CSF, and IL-8 strongly primed a subpopulation of PMN to produce H2O2 in response to N-formyl-methionyl-leucyl-phenylalanine (FMLP), while IL-1 alpha, IL-1 beta, and IL-6 failed to do so.	N-Formylmethionine Leucyl-Phenylalanine	133-137	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
7514637-1	1994	We have investigated mechanisms that regulate the generation of IL-8 by human neutrophils on contact with zymosan particles in vitro.	Zymosan	106-113	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
8006454-5	1994	Sodium lauryl sulfate, phenol, and croton oil induced increases in IL-8 production at non-cytotoxic concentrations in semi-confluent human keratinocyte cultures.	Sodium Dodecyl Sulfate	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
7514637-2	1994	Zymosan stimulated IL-8 production, which increased with increasing particle numbers and was abolished by the protein synthesis inhibitor cycloheximide.	Zymosan	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
8006454-5	1994	Sodium lauryl sulfate, phenol, and croton oil induced increases in IL-8 production at non-cytotoxic concentrations in semi-confluent human keratinocyte cultures.	Phenol	23-29	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
7514637-2	1994	Zymosan stimulated IL-8 production, which increased with increasing particle numbers and was abolished by the protein synthesis inhibitor cycloheximide.	Cycloheximide	138-151	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
8006454-5	1994	Sodium lauryl sulfate, phenol, and croton oil induced increases in IL-8 production at non-cytotoxic concentrations in semi-confluent human keratinocyte cultures.	Croton Oil	35-45	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
7514637-3	1994	IL-8 was detectable in culture supernatant at 8 h reaching a maximum at 24 h. In all further experiments IL-8 was measured at 24 h. mAbs to neutrophil CD18 (60.3 and 6.5E) caused a marked suppression of IL-8 generation, but only if added up to 2 h after zymosan stimulation.	Zymosan	254-261	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8006454-9	1994	Studies using neutralizing antibodies to tumor necrosis factor alpha and IL-1 alpha demonstrated that IL-8 induction by croton oil and phenol occurred directly rather than through autocrine circuits.	Croton Oil	120-130	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
8006454-9	1994	Studies using neutralizing antibodies to tumor necrosis factor alpha and IL-1 alpha demonstrated that IL-8 induction by croton oil and phenol occurred directly rather than through autocrine circuits.	Phenol	135-141	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
7514637-4	1994	An anti-CD11b mAb (KIM 225) substantially inhibited zymosan-induced IL-8 release.	Zymosan	52-59	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
7514637-6	1994	Two selective platelet-activating factor (PAF) receptor antagonists, WEB 2086 and UK 74505, produced a profound suppression of IL-8 generation, when added within 30 min to 1 h of zymosan stimulation.	Zymosan	179-186	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
7514637-8	1994	FMLP, PAF, and a stable PAF agonist did not stimulate significant IL-8 production, however, a calcium ionophore (A23187) did induce IL-8 release and this was suppressed by UK 74505.	Calcium	94-101	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
7514637-8	1994	FMLP, PAF, and a stable PAF agonist did not stimulate significant IL-8 production, however, a calcium ionophore (A23187) did induce IL-8 release and this was suppressed by UK 74505.	Calcimycin	113-119	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
8195701-0	1994	Role of the mevalonate pathway of isoprenoid synthesis in IL-8 generation by activated monocytic cells.	Mevalonic Acid	12-22	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
7514637-9	1994	We conclude that zymosan-induced IL-8 generation involves stimulation of the neutrophil via a CD11b/CD18 receptor resulting in beta 2-integrin mediated activation of signal transduction mechanisms that leads to cytokine synthesis.	Zymosan	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
8195701-0	1994	Role of the mevalonate pathway of isoprenoid synthesis in IL-8 generation by activated monocytic cells.	Terpenes	34-44	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
8195701-5	1994	Under these conditions interleukin-8 (IL-8) production was attenuated (by 50-90%) in response to lipopolysaccharide, granulocyte-macrophage colony-stimulating factor, and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	171-196	C-X-C motif chemokine ligand 8	Homo sapiens	23-36
8204599-0	1994	1H NMR studies of interleukin 8 analogs: characterization of the domains essential for function.	Hydrogen	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
8195701-5	1994	Under these conditions interleukin-8 (IL-8) production was attenuated (by 50-90%) in response to lipopolysaccharide, granulocyte-macrophage colony-stimulating factor, and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	171-196	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
8195701-6	1994	Coincubation of reductase inhibitor-treated cells with mevalonate prevented the attenuation of IL-8 production by reductase inhibitors.	Mevalonic Acid	55-65	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
8195701-7	1994	The effects of isoprenoid depletion on cytokine production were selective: IL-1 beta generation was not inhibited but the production of IL-6 and IL-8 was concomitantly suppressed.	Terpenes	15-25	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
8195701-9	1994	We conclude that isoprenoid generation through the mevalonate pathway is a requirement for IL-8 induction by activated monocytic cells in vitro.	Terpenes	17-27	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
8195701-9	1994	We conclude that isoprenoid generation through the mevalonate pathway is a requirement for IL-8 induction by activated monocytic cells in vitro.	Mevalonic Acid	51-61	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
8204599-1	1994	1H NMR studies were carried out on interleukin 8 (IL-8) analogs in order to probe the structural features that are essential for receptor binding and function.	Hydrogen	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	35-48
8204599-1	1994	1H NMR studies were carried out on interleukin 8 (IL-8) analogs in order to probe the structural features that are essential for receptor binding and function.	Hydrogen	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
8164648-8	1994	First, the N51/IL-8I hybrid in which the N51/KC sequence between cysteines 2 and 3 (or first disulfide bond) is replaced by the corresponding sequence in IL-8 shows IL-8-like properties, indicating that this region is important for specific receptor recognition.	Disulfides	93-102	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
7922353-5	1994	RESULTS: Using affinity co-electrophoresis we found that interleukin-8 preferentially bound a subfraction of heparin that also showed increased affinity for melanoma growth stimulating activity (also known as MGSA, GRO or GRO alpha).	Heparin	109-116	C-X-C motif chemokine ligand 8	Homo sapiens	57-70
7922353-8	1994	This observation led to predictions about the relative affinities of heparan sulfate for interleukin-8 and platelet factor 4, predictions that were confirmed by further binding assays.	Heparitin Sulfate	69-84	C-X-C motif chemokine ligand 8	Homo sapiens	89-124
7513312-7	1994	GM-CSF and G-CSF pretreatment increased the fluoride (NaF)-induced chemiluminescence response by up to 10-fold; the serine/threonine phosphatase inhibitor okadaic acid inhibited GM-CSF- and G-CSF-induced priming.	Fluorides	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
7513312-7	1994	GM-CSF and G-CSF pretreatment increased the fluoride (NaF)-induced chemiluminescence response by up to 10-fold; the serine/threonine phosphatase inhibitor okadaic acid inhibited GM-CSF- and G-CSF-induced priming.	Okadaic Acid	155-167	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
7513312-8	1994	NaF-induced histamine release was enhanced up to 60 and 30% by GM-CSF and G-CSF priming, respectively.	Histamine	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8164648-5	1994	Third, although the changes in intracellular Ca2+ of fura-2/AM-preloaded human neutrophils elicited by N51/KC and IL-8 are similar, pretreatment of the cells with N51/KC did not result in a loss of response to a subsequent treatment with IL-8; in contrast, treatment with IL-8 did result in the subsequent desensitization to N51/KC.	Fura-2	53-59	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
8175759-2	1994	A glucocorticoid, dexamethasone, inhibited the production of a leukocyte chemotactic cytokine, interleukin 8 (IL-8), as well as mRNA expression by a glioblastoma cell line, T98G, stimulated with interleukin 1 (IL-1).	Dexamethasone	18-31	C-X-C motif chemokine ligand 8	Homo sapiens	95-108
8175759-2	1994	A glucocorticoid, dexamethasone, inhibited the production of a leukocyte chemotactic cytokine, interleukin 8 (IL-8), as well as mRNA expression by a glioblastoma cell line, T98G, stimulated with interleukin 1 (IL-1).	Dexamethasone	18-31	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
8175759-3	1994	Dexamethasone also inhibited IL-8 promoter-driven chloramphenicol acetyltransferase (CAT) activities induced by IL-1, suggesting that dexamethasone inhibited IL-8 production mainly at the transcriptional level.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
8175759-3	1994	Dexamethasone also inhibited IL-8 promoter-driven chloramphenicol acetyltransferase (CAT) activities induced by IL-1, suggesting that dexamethasone inhibited IL-8 production mainly at the transcriptional level.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
8175759-3	1994	Dexamethasone also inhibited IL-8 promoter-driven chloramphenicol acetyltransferase (CAT) activities induced by IL-1, suggesting that dexamethasone inhibited IL-8 production mainly at the transcriptional level.	Dexamethasone	134-147	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
8175759-3	1994	Dexamethasone also inhibited IL-8 promoter-driven chloramphenicol acetyltransferase (CAT) activities induced by IL-1, suggesting that dexamethasone inhibited IL-8 production mainly at the transcriptional level.	Dexamethasone	134-147	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
8175759-6	1994	Trimerized kappa B sequence in the IL-8 gene was enough for conferring the induction by IL-1 and inhibition by dexamethasone of CAT activity.	Dexamethasone	111-124	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
8175759-8	1994	Collectively, dexamethasone interfered with the binding of the most essential transcription factor, NF-kappa B, to its cognate cis-element, thereby suppressing the transcription of IL-8 gene.	Dexamethasone	14-27	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
8166094-2	1994	and a 0.05% sodium fluoride (NaF) rinse would significantly reduce decalcification when compared with manual toothbrushing only (control group) or manual toothbrushing and daily use of a NaF rinse (rinse group).	Sodium Fluoride	12-27	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
8166094-2	1994	and a 0.05% sodium fluoride (NaF) rinse would significantly reduce decalcification when compared with manual toothbrushing only (control group) or manual toothbrushing and daily use of a NaF rinse (rinse group).	Sodium Fluoride	12-27	C-X-C motif chemokine ligand 8	Homo sapiens	187-190
8072242-9	1994	Finally, the effect of IL-8 on the 35sulfate turnover of the glomerular basement membrane (GBM) sulfated compounds was evaluated in vitro.	35sulfate	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
8072242-10	1994	A significant decrease in the percentage of residual 35sulfate incorporated in the GBM (41 +/- 5, mean +/- SEM) was observed in cultures treated with IL-8 as compared to those that were not treated with IL-8 (58 +/- 8, P &lt; 0.01).	35sulfate	53-62	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
8164648-8	1994	First, the N51/IL-8I hybrid in which the N51/KC sequence between cysteines 2 and 3 (or first disulfide bond) is replaced by the corresponding sequence in IL-8 shows IL-8-like properties, indicating that this region is important for specific receptor recognition.	Cysteine	65-74	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
8162169-1	1994	The cellular effects of sodium fluoride (NaF) on human bone cells in vitro have been variable and dependent on the culture system used.	Sodium Fluoride	24-39	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
8091005-1	1994	To elucidate the relationship between active oxygen and interleukin 8 (IL-8) in patients with septic adult respiratory distress syndrome (ARDS), we determined the serum levels of alpha-tocopherol, which has an antioxidant action, and IL-8 in seven patients with this disease.	Oxygen	45-51	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
8091005-1	1994	To elucidate the relationship between active oxygen and interleukin 8 (IL-8) in patients with septic adult respiratory distress syndrome (ARDS), we determined the serum levels of alpha-tocopherol, which has an antioxidant action, and IL-8 in seven patients with this disease.	Oxygen	45-51	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
8091005-3	1994	A significant correlation was found between serum alpha-tocopherol level and IL-8 level (r = -0.758, p = 0.0473).	alpha-Tocopherol	50-66	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
8091005-4	1994	These findings suggest that IL-8 activates neutrophils, which produce active oxygen.	Oxygen	77-83	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
8011012-3	1994	The influence of cefodizime (CAS 69739-16-8), a new broad spectrum cephalosporin with immunostimulatory effects, and ceftriaxone on the production of GM-CSF and IL-8 in HBEC primary cultures was investigated.	cefodizime	17-27	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
8162169-7	1994	In the presence of 1,25-dihydroxycholecalciferol (10(-9) mol/l), NaF enhanced alkaline phosphatase (p &lt; 0.05, N = 8), procollagen type I propeptide (p &lt; 0.05, N = 7) and osteocalcin (p &lt; 0.05, N = 7) production by hMS(OB) cells but not by hOB cells.	Calcitriol	19-48	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
8162169-7	1994	In the presence of 1,25-dihydroxycholecalciferol (10(-9) mol/l), NaF enhanced alkaline phosphatase (p &lt; 0.05, N = 8), procollagen type I propeptide (p &lt; 0.05, N = 7) and osteocalcin (p &lt; 0.05, N = 7) production by hMS(OB) cells but not by hOB cells.	propeptide	140-150	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
8163658-2	1994	Incubation of human endothelial cells (ECs) in hypoxia, PO2 approximately 14-18 Torr, led to time-dependent release of IL-8 antigen into the conditioned medium; this was accompanied by increased chemotactic activity for PMNs, blocked by antibody to IL-8.	PO-2	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
8163658-2	1994	Incubation of human endothelial cells (ECs) in hypoxia, PO2 approximately 14-18 Torr, led to time-dependent release of IL-8 antigen into the conditioned medium; this was accompanied by increased chemotactic activity for PMNs, blocked by antibody to IL-8.	PO-2	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	249-253
8144938-4	1994	The protein synthesis inhibitor, cycloheximide, had no detectable effect on levels of IL-8 mRNA expression in PMN incubated in medium alone; however, cycloheximide could selectively modulate IL-8 mRNA transcription in PMN, depending on the cytokine used.	Cycloheximide	33-46	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
8144938-4	1994	The protein synthesis inhibitor, cycloheximide, had no detectable effect on levels of IL-8 mRNA expression in PMN incubated in medium alone; however, cycloheximide could selectively modulate IL-8 mRNA transcription in PMN, depending on the cytokine used.	Cycloheximide	150-163	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
8144935-6	1994	The t1/2 of MIP-1 alpha, MIP-1 beta, and IL-8 mRNA from PMNs treated for 4 h with LPS before actinomycin-D (Ac-D) addition were approximately 40 min, 1.7 h, and 2 h, respectively, whereas the t1/2 from PMNs stimulated for 8 h before Ac-D were 2, 2, and &gt; 9 h, respectively.	Dactinomycin	108-112	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
8144935-6	1994	The t1/2 of MIP-1 alpha, MIP-1 beta, and IL-8 mRNA from PMNs treated for 4 h with LPS before actinomycin-D (Ac-D) addition were approximately 40 min, 1.7 h, and 2 h, respectively, whereas the t1/2 from PMNs stimulated for 8 h before Ac-D were 2, 2, and &gt; 9 h, respectively.	Actinium	108-110	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
8144938-5	1994	Cycloheximide did not affect or alter IL-8 mRNA induction in IL-2-treated PMN but abrogated it in granulocyte macrophage-CSF-treated PMN and super-induced the level of IL-8 mRNA in C. albicans-treated PMN.	Cycloheximide	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
8144935-6	1994	The t1/2 of MIP-1 alpha, MIP-1 beta, and IL-8 mRNA from PMNs treated for 4 h with LPS before actinomycin-D (Ac-D) addition were approximately 40 min, 1.7 h, and 2 h, respectively, whereas the t1/2 from PMNs stimulated for 8 h before Ac-D were 2, 2, and &gt; 9 h, respectively.	Deuterium	105-106	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
8140420-2	1994	An IL-8 analog was chemically synthesized, with the amide nitrogen of leucine-25 methylated to selectivity block formation of hydrogen bonds between monomers and thereby prevent dimerization.	Amides	52-57	C-X-C motif chemokine ligand 8	Homo sapiens	3-7
8140420-2	1994	An IL-8 analog was chemically synthesized, with the amide nitrogen of leucine-25 methylated to selectivity block formation of hydrogen bonds between monomers and thereby prevent dimerization.	Nitrogen	58-66	C-X-C motif chemokine ligand 8	Homo sapiens	3-7
8140420-2	1994	An IL-8 analog was chemically synthesized, with the amide nitrogen of leucine-25 methylated to selectivity block formation of hydrogen bonds between monomers and thereby prevent dimerization.	Leucine	70-77	C-X-C motif chemokine ligand 8	Homo sapiens	3-7
8140420-2	1994	An IL-8 analog was chemically synthesized, with the amide nitrogen of leucine-25 methylated to selectivity block formation of hydrogen bonds between monomers and thereby prevent dimerization.	Hydrogen	126-134	C-X-C motif chemokine ligand 8	Homo sapiens	3-7
8120414-0	1994	Actin polymerization, calcium-transients, and phospholipid metabolism in human neutrophils after stimulation with interleukin-8 and N-formyl peptide.	Phospholipids	46-58	C-X-C motif chemokine ligand 8	Homo sapiens	114-127
7510691-0	1994	The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.	Tacrolimus	73-78	C-X-C motif chemokine ligand 8	Homo sapiens	4-17
7510691-0	1994	The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.	Calcium	112-119	C-X-C motif chemokine ligand 8	Homo sapiens	4-17
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Tacrolimus	17-22	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Tacrolimus	17-22	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Tetradecanoylphorbol Acetate	151-182	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Tetradecanoylphorbol Acetate	151-182	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Tetradecanoylphorbol Acetate	184-187	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Tetradecanoylphorbol Acetate	184-187	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Calcium	193-200	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Calcium	193-200	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Ionomycin	219-228	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Ionomycin	219-228	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
7510691-3	1994	By deleted and mutated analysis of the IL-8 promoters, the AP-1 and kappa B-like sites were identified as the responsive elements for PMA and ionomycin.	Ionomycin	142-151	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
7510691-7	1994	Furthermore, we confirmed the previous report that FK506 suppressed the PMA/ionomycin-induced activation through authentic kappa B site of immunoglobulin (Ig) gene, to which NF-kappa B binding was also decreased by FK506, indicating that both IL-8 kappa B-like site and Ig kappa B site are FK506-sensitive in spite of the difference of binding factors.	Tacrolimus	51-56	C-X-C motif chemokine ligand 8	Homo sapiens	243-247
7510691-7	1994	Furthermore, we confirmed the previous report that FK506 suppressed the PMA/ionomycin-induced activation through authentic kappa B site of immunoglobulin (Ig) gene, to which NF-kappa B binding was also decreased by FK506, indicating that both IL-8 kappa B-like site and Ig kappa B site are FK506-sensitive in spite of the difference of binding factors.	Ionomycin	76-85	C-X-C motif chemokine ligand 8	Homo sapiens	243-247
7510691-7	1994	Furthermore, we confirmed the previous report that FK506 suppressed the PMA/ionomycin-induced activation through authentic kappa B site of immunoglobulin (Ig) gene, to which NF-kappa B binding was also decreased by FK506, indicating that both IL-8 kappa B-like site and Ig kappa B site are FK506-sensitive in spite of the difference of binding factors.	Tacrolimus	215-220	C-X-C motif chemokine ligand 8	Homo sapiens	243-247
7510691-7	1994	Furthermore, we confirmed the previous report that FK506 suppressed the PMA/ionomycin-induced activation through authentic kappa B site of immunoglobulin (Ig) gene, to which NF-kappa B binding was also decreased by FK506, indicating that both IL-8 kappa B-like site and Ig kappa B site are FK506-sensitive in spite of the difference of binding factors.	Tacrolimus	215-220	C-X-C motif chemokine ligand 8	Homo sapiens	243-247
7510691-8	1994	Our results indicate that not only the reported IL-2 NF-AT and NFIL-2A sites and Ig kappa B site, but also the IL-8 AP-1 and kappa B-like sites are terminals of FK506-sensitive pathway involving Ca2+ mobilization.	Tacrolimus	161-166	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
8198453-0	1994	[Fluticasone propionate reduced the production of GM-CSF, IL-6 and IL-8 generated from cultured nasal epithelial cells].	Fluticasone	1-23	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
8118041-9	1994	Both intracellular H2O2 and phagocytosis assays from group III but not groups I-II showed exaggerated upregulation when exposed to NaF (4 mmol/L).	Hydrogen Peroxide	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
8206512-0	1994	Inhibition of interleukin-8 expression by dexamethasone in human cultured airway epithelial cells.	Dexamethasone	42-55	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
8206512-3	1994	We have investigated the effect of dexamethasone on IL-8 expression in primary cultured HAEC obtained from transplantation donors.	Dexamethasone	35-48	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
8206512-6	1994	Dexamethasone suppressed IL-8 mRNA expression and protein synthesis dose-dependently in both resting and stimulated HAEC.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
8206512-7	1994	The half-life of IL-8 mRNA determined in the presence of actinomycin D was less than 1 hr, and dexamethasone preincubation had no effect on mRNA stability.	Dactinomycin	57-70	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
9522744-0	1994	Fluoride profiles of enamel following topical application of neutral and acidulated NaF solution using x-ray photoelectron spectroscopy (ESCA)--an in vitro study.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	84-87
8142378-7	1994	When the incubation medium was supplemented with NaF and AlCl3, and maintained in the dark, both 2-azido[3H]ADP and 8-azido[3H]ADP were able to elicit inhibition of F1-ATPase activity, exactly like ADP did.	2-azido[3h]adp	97-111	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
8142378-7	1994	When the incubation medium was supplemented with NaF and AlCl3, and maintained in the dark, both 2-azido[3H]ADP and 8-azido[3H]ADP were able to elicit inhibition of F1-ATPase activity, exactly like ADP did.	8-azido[3h]adp	116-130	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
8142378-7	1994	When the incubation medium was supplemented with NaF and AlCl3, and maintained in the dark, both 2-azido[3H]ADP and 8-azido[3H]ADP were able to elicit inhibition of F1-ATPase activity, exactly like ADP did.	Adenosine Diphosphate	108-111	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
8117443-0	1994	Interleukin-1-mediated release of interleukin-8 by asbestos-stimulated human pleural mesothelial cells.	Asbestos	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	34-47
8117443-4	1994	Suspensions of amosite, chrysotile, or crocidolite asbestos in concentrations as low as 5 micrograms/ml enhanced release of IL-8 from HPMC during 6 h of incubation at 37 degrees C. Electron microscopy of asbestos-treated HPMC showed that the cells avidly engulfed each of the different types of asbestos fibers.	Asbestos, Amosite	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
8117443-4	1994	Suspensions of amosite, chrysotile, or crocidolite asbestos in concentrations as low as 5 micrograms/ml enhanced release of IL-8 from HPMC during 6 h of incubation at 37 degrees C. Electron microscopy of asbestos-treated HPMC showed that the cells avidly engulfed each of the different types of asbestos fibers.	Asbestos, Crocidolite	39-59	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
8117443-4	1994	Suspensions of amosite, chrysotile, or crocidolite asbestos in concentrations as low as 5 micrograms/ml enhanced release of IL-8 from HPMC during 6 h of incubation at 37 degrees C. Electron microscopy of asbestos-treated HPMC showed that the cells avidly engulfed each of the different types of asbestos fibers.	Asbestos	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
8117443-4	1994	Suspensions of amosite, chrysotile, or crocidolite asbestos in concentrations as low as 5 micrograms/ml enhanced release of IL-8 from HPMC during 6 h of incubation at 37 degrees C. Electron microscopy of asbestos-treated HPMC showed that the cells avidly engulfed each of the different types of asbestos fibers.	hydroxypropylmethylcellulose-lactose matrix	134-138	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
8117443-6	1994	Identity of IL-8 in HPMC supernatants was established by absorption with an antibody to IL-8.	hydroxypropylmethylcellulose-lactose matrix	20-24	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
8117443-6	1994	Identity of IL-8 in HPMC supernatants was established by absorption with an antibody to IL-8.	hydroxypropylmethylcellulose-lactose matrix	20-24	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
8117443-7	1994	Preincubation of HPMC with IL-1 receptor antagonist (IL-1ra) significantly decreased release of IL-8 after stimulation with amosite or crocidolite asbestos.	hydroxypropylmethylcellulose-lactose matrix	17-21	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
8117443-7	1994	Preincubation of HPMC with IL-1 receptor antagonist (IL-1ra) significantly decreased release of IL-8 after stimulation with amosite or crocidolite asbestos.	Asbestos, Amosite	124-131	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
8117443-7	1994	Preincubation of HPMC with IL-1 receptor antagonist (IL-1ra) significantly decreased release of IL-8 after stimulation with amosite or crocidolite asbestos.	Asbestos, Crocidolite	135-155	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
8117443-8	1994	We conclude that HPMC release IL-8 in response to asbestos stimulation and that the response is, in part, mediated by IL-1, mainly in the form of IL-1 alpha.	hydroxypropylmethylcellulose-lactose matrix	17-21	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
8117443-8	1994	We conclude that HPMC release IL-8 in response to asbestos stimulation and that the response is, in part, mediated by IL-1, mainly in the form of IL-1 alpha.	Asbestos	50-58	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
8031999-8	1994	Of three disease-modifying drugs tested, dexamethasone and gold sodium thiomalate (GST) inhibited the production of IL-8 and MCP-1, while methotrexate (MTX) was inactive.	Dexamethasone	41-54	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
8031999-8	1994	Of three disease-modifying drugs tested, dexamethasone and gold sodium thiomalate (GST) inhibited the production of IL-8 and MCP-1, while methotrexate (MTX) was inactive.	sodium thiomalate	64-81	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
8031999-8	1994	Of three disease-modifying drugs tested, dexamethasone and gold sodium thiomalate (GST) inhibited the production of IL-8 and MCP-1, while methotrexate (MTX) was inactive.	Gold Sodium Thiomalate	83-86	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
8031999-9	1994	Dexamethasone reduced the production of MCP-1 and IL-8 by 20-65% and 60-80%, respectively, whilst GST inhibited MCP-1 and IL-8 synthesis in suboptimally, but not in optimally stimulated synoviocytes.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
8133058-6	1994	We observed complete cross-competition of unlabeled IL-8 with 125I-labeled-NAP-2 and of unlabeled NAP-2 with 125I-labeled IL-8, indicating the absence of monospecific binding sites for either chemokine.	Iodine-125	109-113	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
8120414-2	1994	Stimulation of human neutrophils with IL-8 induced a rapid polymerization of actin as detected by 7-nitrobenz-2-oxa-1,3-diazol-(NBD)-phallacidin staining of f-actin and reduction of monitored right-angle light scatter.	7-nitrobenz-2-oxa-1,3-diazol-(nbd)	98-132	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
8120414-2	1994	Stimulation of human neutrophils with IL-8 induced a rapid polymerization of actin as detected by 7-nitrobenz-2-oxa-1,3-diazol-(NBD)-phallacidin staining of f-actin and reduction of monitored right-angle light scatter.	phallacidin	133-144	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
8120414-6	1994	Moreover, [32P]phosphatidic acid (PA) production stimulated by IL-8 was minimal and transient as compared to the response activated by N-formyl peptide.	[32p]phosphatidic acid	10-32	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
8120414-6	1994	Moreover, [32P]phosphatidic acid (PA) production stimulated by IL-8 was minimal and transient as compared to the response activated by N-formyl peptide.	Protactinium	34-36	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
8120414-9	1994	This study indicates that IL-8 is a potent activator of intracellular events presumably required for chemotaxis, but a relatively weak activator for events associated with superoxide anion generation and proinflammatory activity.	Superoxides	172-188	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
7735949-8	1994	Therefore, ET-1-treated monocytes probably upregulate neutrophil superoxide production via a mechanism which includes IL-8.	Superoxides	65-75	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
8032126-2	1994	Sodium fluoride (NaF) did not affect the extracellular pH of sperm, except that a slight acidification was caused by the 250 mM dose only.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
8032126-6	1994	Sperm glutathione levels also showed a time-dependent decrease with complete depletion after 20 min indicating rapid glutathione oxidation in detoxification of the NaF.	Glutathione	6-17	C-X-C motif chemokine ligand 8	Homo sapiens	164-167
8032126-6	1994	Sperm glutathione levels also showed a time-dependent decrease with complete depletion after 20 min indicating rapid glutathione oxidation in detoxification of the NaF.	Glutathione	117-128	C-X-C motif chemokine ligand 8	Homo sapiens	164-167
8145725-5	1994	Halothane (1%) increased basal as well as isoprenaline-, NaF-, cholera toxin-, and guanylylimidodiphosphate [Gpp(NH)p]-stimulated adenylate cyclase in human myocardial membranes (p &lt; 0.05).	Halothane	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
7907421-4	1994	A ligand for p185, neu-activating factor (NAF), specifically binds to neu receptor and increases the p185c-neu tyrosine phosphorylation in vitro and in vivo in a dose-dependent manner.	Tyrosine	111-119	C-X-C motif chemokine ligand 8	Homo sapiens	42-45
7508438-0	1994	Sulfatides trigger increase of cytosolic free calcium and enhanced expression of tumor necrosis factor-alpha and interleukin-8 mRNA in human neutrophils.	Sulfoglycosphingolipids	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	113-126
7515597-5	1994	This method was applied to cloning of a cDNA encoding interleukin 8 (IL-8) from a cDNA library prepared from phorbol myristate acetate-treated U937 cells.	Tetradecanoylphorbol Acetate	109-134	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
7515597-5	1994	This method was applied to cloning of a cDNA encoding interleukin 8 (IL-8) from a cDNA library prepared from phorbol myristate acetate-treated U937 cells.	Tetradecanoylphorbol Acetate	109-134	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
7908651-1	1994	Porphyromonas gingivalis fimbriae as well as synthetic peptides that mimic the fimbrial subunit protein, which includes the amino acid sequence XLTXXLTXXNXX, induced high production of proinflammatory cytokines such as interleukin-1 beta, interleukin-6, interleukin-8, tumor necrosis factor-alpha in human peripheral blood monocyte/macrophage cultures.	Peptides	55-63	C-X-C motif chemokine ligand 8	Homo sapiens	254-296
7508438-9	1994	Sulfatides also triggered an increase of tumor necrosis factor-alpha and interleukin-8 mRNAs in neutrophils.	Sulfoglycosphingolipids	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	73-86
8027281-4	1994	In endometrium, the stage of the menstrual cycle did not affect IL-8 production but a 10(-6) M concentration of progesterone or dexamethasone significantly reduced the concentration of IL-8 in medium after 24 h. After a further 24 h with lipopolysaccharide (LPS) stimulation, only MPA and dexamethasone inhibited production significantly.	Progesterone	112-124	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
8027281-6	1994	The IL-8 produced in uterine tissues might act synergistically with prostaglandin E (PGE), a likely site for this interaction being blood vessels where PGE production is also repressed by progesterone.	Prostaglandins E	68-83	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
8027281-4	1994	In endometrium, the stage of the menstrual cycle did not affect IL-8 production but a 10(-6) M concentration of progesterone or dexamethasone significantly reduced the concentration of IL-8 in medium after 24 h. After a further 24 h with lipopolysaccharide (LPS) stimulation, only MPA and dexamethasone inhibited production significantly.	Dexamethasone	128-141	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
8027281-6	1994	The IL-8 produced in uterine tissues might act synergistically with prostaglandin E (PGE), a likely site for this interaction being blood vessels where PGE production is also repressed by progesterone.	Prostaglandins E	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
8027281-6	1994	The IL-8 produced in uterine tissues might act synergistically with prostaglandin E (PGE), a likely site for this interaction being blood vessels where PGE production is also repressed by progesterone.	Prostaglandins E	152-155	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
8027281-4	1994	In endometrium, the stage of the menstrual cycle did not affect IL-8 production but a 10(-6) M concentration of progesterone or dexamethasone significantly reduced the concentration of IL-8 in medium after 24 h. After a further 24 h with lipopolysaccharide (LPS) stimulation, only MPA and dexamethasone inhibited production significantly.	Dexamethasone	289-302	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
8027281-6	1994	The IL-8 produced in uterine tissues might act synergistically with prostaglandin E (PGE), a likely site for this interaction being blood vessels where PGE production is also repressed by progesterone.	Progesterone	188-200	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
8027281-5	1994	In chorion cells, IL-8 production was significantly decreased by both MPA and dexamethasone in the LPS stimulated cells but the reduction in the first 24 h was not significant.	Dexamethasone	78-91	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
8113959-0	1994	Liposomal muramyl tripeptide up-regulates interleukin-1 alpha, interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-8 gene expression in human monocytes.	muramyl tripeptide	10-28	C-X-C motif chemokine ligand 8	Homo sapiens	130-143
8193081-0	1994	Regulatory effects of 1,25-dihydroxyvitamin D3 and a novel vitamin D3 analogue MC903 on secretion of interleukin-1 alpha (IL-1 alpha) and IL-8 by normal human keratinocytes and a human squamous cell carcinoma cell line (HSC-1).	Cholecalciferol	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
8193081-5	1994	In the present study, we investigated the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and its analogue MC903 on IL-1 alpha and IL-8 secretion by human keratinocytes in vitro.	Calcitriol	53-79	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
8193081-5	1994	In the present study, we investigated the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and its analogue MC903 on IL-1 alpha and IL-8 secretion by human keratinocytes in vitro.	Calcitriol	79-90	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
8193081-10	1994	Stimulation of NHKs with phorbol 12-myristate 13-acetate(PMA) and lipopolysaccharide(LPS) resulted in an increase of IL-8 and decrease of IL-1 alpha in the culture supernatants.	Tetradecanoylphorbol Acetate	25-56	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
8193081-10	1994	Stimulation of NHKs with phorbol 12-myristate 13-acetate(PMA) and lipopolysaccharide(LPS) resulted in an increase of IL-8 and decrease of IL-1 alpha in the culture supernatants.	Tetradecanoylphorbol Acetate	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
8193081-11	1994	Addition of 1,25(OH)2D3 or MC903 inhibited the increased secretion of IL-8 but restored decreased secretion of IL-1 alpha from stimulated NHKs dose dependently.	Calcitriol	12-23	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
8193081-11	1994	Addition of 1,25(OH)2D3 or MC903 inhibited the increased secretion of IL-8 but restored decreased secretion of IL-1 alpha from stimulated NHKs dose dependently.	calcipotriene	27-32	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
8193081-12	1994	Hydrocortisone and cyclosporin A showed similar inhibitory effects on PMA/LPS-increased IL-8 secretion from NHKs but had little effect of restoring IL-1 alpha.	Hydrocortisone	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
8193081-12	1994	Hydrocortisone and cyclosporin A showed similar inhibitory effects on PMA/LPS-increased IL-8 secretion from NHKs but had little effect of restoring IL-1 alpha.	Cyclosporine	19-32	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
8193081-12	1994	Hydrocortisone and cyclosporin A showed similar inhibitory effects on PMA/LPS-increased IL-8 secretion from NHKs but had little effect of restoring IL-1 alpha.	Tetradecanoylphorbol Acetate	70-73	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
8113959-4	1994	Monocyte interleukin (IL)-1 alpha, IL-1 beta, IL-6, IL-8 and tumor necrosis factor (TNF)-alpha expression were all up-regulated after a 2-h incubation with L-MTP-PE.	L-MTP-PE	156-164	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
8307164-3	1994	A peptide corresponding to residues 1-40 of the IL-8 type 1 receptor (IL8-r1) was titrated into a sample of uniformly 15N-labeled IL-8.	15n	118-121	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
8202627-0	1994	Inhibition of IL-6 and IL-8 production in human fibroblast cell lines by 1,25 (OH)2 vitamin D3 and two of its analogs with lower calcemic activity.	Calcitriol	73-94	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
8202627-1	1994	In human fibroblast cultures TPA increased IL-6 and IL-8 production.	Tetradecanoylphorbol Acetate	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
8307164-3	1994	A peptide corresponding to residues 1-40 of the IL-8 type 1 receptor (IL8-r1) was titrated into a sample of uniformly 15N-labeled IL-8.	15n	118-121	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
8001052-5	1994	Data from these studies established the ability of the in vitro model to provide reproducible results, to demonstrate significant dose-related differences in the effects of both NaF- and Na2PO3F-containing treatments on dentin fluoride uptake and demineralization, and to detect a fluoride-induced reduction in dentin caries, relative to a nonfluoride control, similar to results established in a clinical trial.	Fluorides	227-235	C-X-C motif chemokine ligand 8	Homo sapiens	178-181
8276881-14	1994	The ability of LPS to induce IL-8 expression was suppressed by recombinant human IL-4 and dexamethasone in a concentration-dependent manner.	Dexamethasone	90-103	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
8073837-7	1994	IL-8 and huGRO mRNAs were constitutively produced in KC, as was demonstrated after incubation with cycloheximide.	Cycloheximide	99-112	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8187790-0	1993	Inhibition of endotoxin-induced interleukin 8 release by teicoplanin in human whole blood.	Teicoplanin	57-68	C-X-C motif chemokine ligand 8	Homo sapiens	32-45
8281849-6	1994	At the cellular level, 5-aminosalicylic acid inhibited phorbol myristate acetate (100 ng/ml)-activated superoxide generation to 82.3 +/- 9.3%, the formylmethionyl leucyl peptide (10(-5) M) to 61.0 +/- 6.8%, and the NaF (20 mM)-stimulated production to 32.3 +/- 3.2% (mean +/- SD, P &lt; 0.01).	Mesalamine	23-44	C-X-C motif chemokine ligand 8	Homo sapiens	215-218
8281849-6	1994	At the cellular level, 5-aminosalicylic acid inhibited phorbol myristate acetate (100 ng/ml)-activated superoxide generation to 82.3 +/- 9.3%, the formylmethionyl leucyl peptide (10(-5) M) to 61.0 +/- 6.8%, and the NaF (20 mM)-stimulated production to 32.3 +/- 3.2% (mean +/- SD, P &lt; 0.01).	Tetradecanoylphorbol Acetate	55-80	C-X-C motif chemokine ligand 8	Homo sapiens	215-218
8281849-6	1994	At the cellular level, 5-aminosalicylic acid inhibited phorbol myristate acetate (100 ng/ml)-activated superoxide generation to 82.3 +/- 9.3%, the formylmethionyl leucyl peptide (10(-5) M) to 61.0 +/- 6.8%, and the NaF (20 mM)-stimulated production to 32.3 +/- 3.2% (mean +/- SD, P &lt; 0.01).	Superoxides	103-113	C-X-C motif chemokine ligand 8	Homo sapiens	215-218
8085219-1	1994	Fluoridated toothpicks (John O. Butler Co.), containing an average of 0.80 mg F as NaF, demonstrated a quick F release in vitro after 1 min immersion in distilled water (0.13 mg; 16%).	Water	163-168	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
8244994-3	1993	In lipopolysaccharide-stimulated human whole blood, the OH radical scavenger dimethyl sulfoxide (Me2SO) dramatically inhibited (approximately 90%) IL-8 production, but had minimal effects on the production of tumor necrosis factor, interleukin 1 beta (IL-1), and IL-6.	oh radical	56-66	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
8244994-3	1993	In lipopolysaccharide-stimulated human whole blood, the OH radical scavenger dimethyl sulfoxide (Me2SO) dramatically inhibited (approximately 90%) IL-8 production, but had minimal effects on the production of tumor necrosis factor, interleukin 1 beta (IL-1), and IL-6.	Dimethyl Sulfoxide	77-95	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
8244994-3	1993	In lipopolysaccharide-stimulated human whole blood, the OH radical scavenger dimethyl sulfoxide (Me2SO) dramatically inhibited (approximately 90%) IL-8 production, but had minimal effects on the production of tumor necrosis factor, interleukin 1 beta (IL-1), and IL-6.	me2so	97-102	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
8244994-4	1993	To determine whether NADPH-oxidase-generated free radicals were critical in the regulation of IL-8, studies were performed using blood from patients with chronic granulomatous disease.	Free Radicals	45-58	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
8244994-5	1993	In both normal individuals and patients with chronic granulomatous disease, production of IL-8 could be initiated with lipopolysaccharide, phytohemagglutinin, or aggregated immune complexes, and this production could be inhibited by Me2SO (1% v/v).	me2so	233-238	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
8244994-7	1993	In the human hepatoma cell line Hep-G2, Me2SO dose-dependently inhibited tumor necrosis factor-stimulated IL-8 production, with a 74 +/- 1% reduction observed at a Me2SO concentration of 1%.	me2so	40-45	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
8244994-7	1993	In the human hepatoma cell line Hep-G2, Me2SO dose-dependently inhibited tumor necrosis factor-stimulated IL-8 production, with a 74 +/- 1% reduction observed at a Me2SO concentration of 1%.	me2so	164-169	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
8244994-8	1993	Direct exposure to ROI demonstrated that H2O2 stimulated IL-8 production in a dose-dependent manner in Hep-G2 cells, A549 pulmonary type II epithelial cells, and human skin fibroblasts; this induction could be prevented by addition of catalase.	Hydrogen Peroxide	41-45	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
8124912-5	1993	However, a correlation was observed between SF levels of IL-8 with those of lactate, LDH, beta 2-microglobulin and glucose.	Lactic Acid	76-83	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
8262617-0	1994	Lipoteichoic acid induces secretion of interleukin-8 from human blood monocytes: a cellular and molecular analysis.	lipoteichoic acid	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
8262617-6	1994	The expression of IL-8 mRNA from LTA- but not lipopolysaccharide (LPS)-treated PBM was superinduced by concomitant treatment with cycloheximide, indicating that the expression of IL-8 mRNA from LTA-treated PBM was negatively controlled by repressor proteins.	Cycloheximide	130-143	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
8262617-6	1994	The expression of IL-8 mRNA from LTA- but not lipopolysaccharide (LPS)-treated PBM was superinduced by concomitant treatment with cycloheximide, indicating that the expression of IL-8 mRNA from LTA-treated PBM was negatively controlled by repressor proteins.	Cycloheximide	130-143	C-X-C motif chemokine ligand 8	Homo sapiens	179-183
8254194-11	1994	However, treatment of monocytes with cycloheximide resulted in the superinduction of IL-8 compared with control monocytes.	Cycloheximide	37-50	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
7885789-0	1994	Urine interleukin-6 and interleukin-8 in children with acute pyelonephritis, in relation to DMSA scintigraphy in the acute phase and at 1-year follow-up.	Technetium Tc 99m Dimercaptosuccinic Acid	92-96	C-X-C motif chemokine ligand 8	Homo sapiens	24-37
7885789-2	1994	The urine IL-6 and IL-8/creatinine quotients were also related to the urine N-acetyl-beta-D-glucosaminidase (NAG) and albumin/creatinine quotients.	Creatinine	126-136	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
7809956-2	1994	Adenylate cyclase sensitivity to sodium inhibition was different upon cyclase stimulation with 1-isoproterenol, Gpp(NH)p and NaF.	Sodium	33-39	C-X-C motif chemokine ligand 8	Homo sapiens	125-128
8253721-6	1993	The identical effects of GTP gamma S and NaF suggest that the GTP-sensitive element is a heterotrimeric G-protein.	Guanosine Triphosphate	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
8267589-6	1993	Activators of protein kinase C, phorbol myristate acetate (PMA) and 1-oleyl-2-acetyl-sn-glycerol (OAG), inhibited cytosolic Ca(2+)-increase completely when induced by IL-8 and by 68-82% in the case of fMLP.	Tetradecanoylphorbol Acetate	32-57	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
8267589-6	1993	Activators of protein kinase C, phorbol myristate acetate (PMA) and 1-oleyl-2-acetyl-sn-glycerol (OAG), inhibited cytosolic Ca(2+)-increase completely when induced by IL-8 and by 68-82% in the case of fMLP.	Tetradecanoylphorbol Acetate	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
8267589-6	1993	Activators of protein kinase C, phorbol myristate acetate (PMA) and 1-oleyl-2-acetyl-sn-glycerol (OAG), inhibited cytosolic Ca(2+)-increase completely when induced by IL-8 and by 68-82% in the case of fMLP.	1-oleyl-2-acetyl-sn-glycerol	68-96	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
8267589-6	1993	Activators of protein kinase C, phorbol myristate acetate (PMA) and 1-oleyl-2-acetyl-sn-glycerol (OAG), inhibited cytosolic Ca(2+)-increase completely when induced by IL-8 and by 68-82% in the case of fMLP.	1-oleoyl-2-acetylglycerol	98-101	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
8116830-2	1993	This study was designed to investigate the relationship between chronic alcohol ingestion and cessation with respect to release of interleukin-6 (IL-6) and interleukin-8 (IL-8) using highly specific and sensitive ELISA assays, as well as a functional assay, natural killer cell cytotoxic activity.	Alcohols	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	156-169
8116830-2	1993	This study was designed to investigate the relationship between chronic alcohol ingestion and cessation with respect to release of interleukin-6 (IL-6) and interleukin-8 (IL-8) using highly specific and sensitive ELISA assays, as well as a functional assay, natural killer cell cytotoxic activity.	Alcohols	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	171-175
8124912-5	1993	However, a correlation was observed between SF levels of IL-8 with those of lactate, LDH, beta 2-microglobulin and glucose.	Glucose	115-122	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
8138326-4	1993	In the recent past, meta-analytic techniques employed on data concerning &gt; 14,000 clinical trial subjects from 12 studies, have established that the use of NaF in a correctly formulated silica base provides superior caries protection than does either an NaF + SMFP, or SMFP dentifrice.	Silicon Dioxide	189-195	C-X-C motif chemokine ligand 8	Homo sapiens	159-162
8244273-0	1993	Production of chemotactic factor, interleukin-8, from hepatocytes exposed to ethanol.	Ethanol	77-84	C-X-C motif chemokine ligand 8	Homo sapiens	34-47
8244273-7	1993	These results suggest that a major part of the proteinous chemotactic factors released from hepatocytes exposed to ethanol could be a dimer form of interleukin-8, one of the proinflammatory cytokines, possibly contributing to the pathogenesis of alcoholic hepatitis.	Ethanol	115-122	C-X-C motif chemokine ligand 8	Homo sapiens	148-161
8187790-4	1993	Interleukin 8 concentrations increased over time up to 24 h. When LPS was preincubated with teicoplanin (antibiotic: LPS ratio 20:1, w/w), interleukin 8 concentrations were found significantly (p &lt; 0.05) reduced at 4, 8 and 24 h after LPS challenge.	Teicoplanin	92-103	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
8187790-4	1993	Interleukin 8 concentrations increased over time up to 24 h. When LPS was preincubated with teicoplanin (antibiotic: LPS ratio 20:1, w/w), interleukin 8 concentrations were found significantly (p &lt; 0.05) reduced at 4, 8 and 24 h after LPS challenge.	Teicoplanin	92-103	C-X-C motif chemokine ligand 8	Homo sapiens	139-152
8187790-6	1993	In this experiment model, a teicoplanin:LPS ratio 100-fold less than the ratio achievable in plasma of septic shock patients was able to reduce interleukin 8, which has been correlated with the severity of septic disease.	Teicoplanin	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	144-157
8245474-2	1993	We show that after GM-CSF treatment, the exposure of human neutrophils to IL-8 results in the synthesis of leukotriene (LT)B4 and platelet-activating factor.	Leukotrienes	107-118	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
8245474-4	1993	Accordingly, IL-8 induced a substantial release of 3H-arachidonic acid in GM-CSF-treated PMN.	3h-arachidonic acid	51-70	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
8245474-8	1993	Finally, pertussis toxin and the 5-LO translocation inhibitor, MK-886, both blocked the IL-8-elicited 5-LO activation.	MK-886	63-69	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
8245475-4	1993	Competition binding with 125I-labeled IL-8, however, showed large differences for several of the IL-8 mutants between alpha and beta receptors.	Iodine-125	25-29	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
8245475-4	1993	Competition binding with 125I-labeled IL-8, however, showed large differences for several of the IL-8 mutants between alpha and beta receptors.	Iodine-125	25-29	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
8245475-10	1993	If the ELR sequence of IL-8 was substituted with alanines or if the carboxyl terminus distal to C50 was replaced with the MGSA sequence, a reduction occurred in binding competition.	Alanine	49-57	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
8123758-5	1993	Cd, over a wide range of concentrations, did induce human PBMC to produce large amounts of bioactive IL-8, the maximal induction being observed at 10(-4) M. The production was inhibited specifically by a metal chelating agent, ethylenediaminetetraacetic acid (EDTA).	Edetic Acid	260-264	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
8123758-0	1993	Cadmium induces interleukin-8 production in human peripheral blood mononuclear cells with the concomitant generation of superoxide radicals.	Cadmium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	16-29
8123758-6	1993	Steady level of IL-8 mRNA increased within 30 min after the addition of Cd and reached a maximal level at 2 h, decreasing thereafter.	Cadmium	72-74	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
8123758-4	1993	Hence, in this study we investigated whether Cd induced IL-8 production in human peripheral blood mononuclear cells (PBMC).	Cadmium	45-47	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
8123758-8	1993	Concomitantly with the induction of IL-8, within 10 min Cd generated reactive oxygen intermediates (ROI) in human PBMC.	Cadmium	56-58	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
8123758-5	1993	Cd, over a wide range of concentrations, did induce human PBMC to produce large amounts of bioactive IL-8, the maximal induction being observed at 10(-4) M. The production was inhibited specifically by a metal chelating agent, ethylenediaminetetraacetic acid (EDTA).	Cadmium	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
8123758-5	1993	Cd, over a wide range of concentrations, did induce human PBMC to produce large amounts of bioactive IL-8, the maximal induction being observed at 10(-4) M. The production was inhibited specifically by a metal chelating agent, ethylenediaminetetraacetic acid (EDTA).	Edetic Acid	227-258	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
8123758-8	1993	Concomitantly with the induction of IL-8, within 10 min Cd generated reactive oxygen intermediates (ROI) in human PBMC.	reactive oxygen intermediates	69-98	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
8123758-10	1993	This notion was also supported by our findings that a superoxide generating agent, paraquat, induced IL-8 production in human PBMC and that NAC blocked this paraquat-induced IL-8 production.	Superoxides	54-64	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
8123758-10	1993	This notion was also supported by our findings that a superoxide generating agent, paraquat, induced IL-8 production in human PBMC and that NAC blocked this paraquat-induced IL-8 production.	Superoxides	54-64	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
8123758-10	1993	This notion was also supported by our findings that a superoxide generating agent, paraquat, induced IL-8 production in human PBMC and that NAC blocked this paraquat-induced IL-8 production.	Paraquat	83-91	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
8123758-10	1993	This notion was also supported by our findings that a superoxide generating agent, paraquat, induced IL-8 production in human PBMC and that NAC blocked this paraquat-induced IL-8 production.	Paraquat	83-91	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
8123758-10	1993	This notion was also supported by our findings that a superoxide generating agent, paraquat, induced IL-8 production in human PBMC and that NAC blocked this paraquat-induced IL-8 production.	Paraquat	157-165	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
8023744-4	1993	One of the peptides, IL-8(3-25), inhibited the neutrophil chemotactic activity of recombinant IL-8 (rIL-8) which had been preheated to 40 degrees C but did not reduce neutrophil chemokinesis, or the chemotactic activity of unheated rIL-8, FMLP, C5a or LTB4.	ril-8	100-105	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
8108182-0	1993	Induction of interleukin-8 expression in neuroblastoma cells by retinoic acid: implication of leukocyte chemotaxis and activation.	Tretinoin	64-77	C-X-C motif chemokine ligand 8	Homo sapiens	13-26
8108182-6	1993	RA-treated but not untreated SK-N-SH cells expressed IL-8 mRNA in a time- and dose-dependent fashion.	Tretinoin	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
8108182-7	1993	As determined by ELISA, IL-8 levels were detectable in the culture supernatants from RA-treated, but not untreated, neuroblastoma cells (2.65 +/- 0.43 versus 0.05 +/- 0.04 ng/mL).	Tretinoin	85-87	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
8108182-10	1993	These results suggest that RA-induced neuroblastoma cell differentiation is associated with production of functional IL-8, which may be involved in the leukocyte infiltration and activation resulting in tumor regression.	Tretinoin	27-29	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
8304046-1	1993	In this study we tested the effects of sodium fluoride (NaF) in serum-free cultures of human marrow stromal osteoblast-like [hMS(OB)] cells.	Sodium Fluoride	39-54	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
8304046-3	1993	NaF alone did not increase type I collagen production, but in the presence of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] (10(-9) M), NaF enhanced type I collagen production in a dose-dependent way to 300% of 1,25-(OH)2D3-treated control cultures.	1,25-dihydroxyvitamin d3 [1,25-(oh)2d3	78-116	C-X-C motif chemokine ligand 8	Homo sapiens	130-133
8304046-3	1993	NaF alone did not increase type I collagen production, but in the presence of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] (10(-9) M), NaF enhanced type I collagen production in a dose-dependent way to 300% of 1,25-(OH)2D3-treated control cultures.	Calcitriol	104-116	C-X-C motif chemokine ligand 8	Homo sapiens	130-133
8023744-4	1993	One of the peptides, IL-8(3-25), inhibited the neutrophil chemotactic activity of recombinant IL-8 (rIL-8) which had been preheated to 40 degrees C but did not reduce neutrophil chemokinesis, or the chemotactic activity of unheated rIL-8, FMLP, C5a or LTB4.	ril-8	100-105	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
7988766-0	1993	Fluoride release in vitro from various glass ionomer cements and resin composites after exposure to NaF solutions.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
7988766-8	1993	After exposure to NaF, the fluoride release was significantly higher for the silver cermet material than for the other glass ionomers tested.	Fluorides	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
7988766-8	1993	After exposure to NaF, the fluoride release was significantly higher for the silver cermet material than for the other glass ionomers tested.	silver cermet	77-90	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
8214944-4	1993	Therefore, we conducted a prospective study in order to investigate whether methylprednisolone (MP) pretreatment (30 mg/kg) could influence the appearance of IL-8 (a recently discovered cytokine with potent neutrophil-chemotactic activity) in the peripheral circulation.	Methylprednisolone	76-94	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
8406851-9	1993	Moreover, the presence of a primed subpopulation of blood PMN with respect to H2O2 production indicates that IL-8 may contribute to the neutrophil-mediated process in the pathogenesis of ARDS and pneumonia.	Hydrogen Peroxide	78-82	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
8413306-1	1993	The interleukin-8 promoter is transcriptionally activated by interleukin-1, tumor necrosis factor alpha, phorbol myristate acetate, or hepatitis B virus X protein through a sequence located between positions -91 and -71.	Tetradecanoylphorbol Acetate	105-130	C-X-C motif chemokine ligand 8	Homo sapiens	4-17
8400299-10	1993	In leukemic cells expressing the IL-8 receptor, IL-8 induced cytosolic free calcium changes, indicating activation of the classical signaling pathway.	Calcium	76-83	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
8400299-10	1993	In leukemic cells expressing the IL-8 receptor, IL-8 induced cytosolic free calcium changes, indicating activation of the classical signaling pathway.	Calcium	76-83	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
8400301-9	1993	IL-8 caused a rapid increase in neutrophil intracellular calcium that could be completely inhibited by the chelating agent 1,2-bis(o-aminophenoxy)ethane-N,N-N",N"-tetraacetic acid (BAPTA).	Calcium	57-64	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8400301-9	1993	IL-8 caused a rapid increase in neutrophil intracellular calcium that could be completely inhibited by the chelating agent 1,2-bis(o-aminophenoxy)ethane-N,N-N",N"-tetraacetic acid (BAPTA).	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	123-179	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8400301-9	1993	IL-8 caused a rapid increase in neutrophil intracellular calcium that could be completely inhibited by the chelating agent 1,2-bis(o-aminophenoxy)ethane-N,N-N",N"-tetraacetic acid (BAPTA).	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	181-186	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8400301-10	1993	However, BAPTA-treated neutrophils retained the ability to increase F-actin in response to IL-8.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	9-14	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
8400301-11	1993	Similar results were seen with fMLP, indicating that, similar to fMLP, the IL-8-induced actin response is mediated through pertussis-toxin-sensitive G-proteins but is neither dependent on PKC nor increases in cytosolic calcium.	Calcium	219-226	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
7694480-3	1993	In particular, we assessed whether dexamethasone was capable of inhibiting the tumor necrosis factor-alpha (TNF-alpha)-mediated secretion of interleukin-6 (IL-6), interleukin-8 (IL-8), and granulocyte colony-stimulating factor (G-CSF) by a human bronchial epithelial cell line (BEAS-2B).	Dexamethasone	35-48	C-X-C motif chemokine ligand 8	Homo sapiens	163-176
7694480-3	1993	In particular, we assessed whether dexamethasone was capable of inhibiting the tumor necrosis factor-alpha (TNF-alpha)-mediated secretion of interleukin-6 (IL-6), interleukin-8 (IL-8), and granulocyte colony-stimulating factor (G-CSF) by a human bronchial epithelial cell line (BEAS-2B).	Dexamethasone	35-48	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
7694480-7	1993	Although dexamethasone appeared to reduce both the secretion of immunoreactive IL-8 and accumulation of IL-8 mRNA, the inhibitory effects did not reach statistical significance.	Dexamethasone	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
7694480-7	1993	Although dexamethasone appeared to reduce both the secretion of immunoreactive IL-8 and accumulation of IL-8 mRNA, the inhibitory effects did not reach statistical significance.	Dexamethasone	9-22	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
29016269-6	1993	In the presence of NaCl, Na2SO4, MgClg, CaCl2, NaF and urea, the adsorption was slightly affected.	Sodium Chloride	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
29016269-6	1993	In the presence of NaCl, Na2SO4, MgClg, CaCl2, NaF and urea, the adsorption was slightly affected.	sodium sulfate	25-31	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
8228330-13	1993	Cycloheximide treatment blocked this IL-8 protein induction.	Cycloheximide	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
7902747-3	1993	Noradrenaline-, ATP-, histamine- and glutamate-evoked [3H]-inositol phosphate accumulations were potentiated to varying degrees in PKC-depleted cultures whilst those evoked by carbachol and NaF were reduced and unchanged respectively.	Norepinephrine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	190-193
7902747-3	1993	Noradrenaline-, ATP-, histamine- and glutamate-evoked [3H]-inositol phosphate accumulations were potentiated to varying degrees in PKC-depleted cultures whilst those evoked by carbachol and NaF were reduced and unchanged respectively.	Adenosine Triphosphate	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	190-193
7902747-3	1993	Noradrenaline-, ATP-, histamine- and glutamate-evoked [3H]-inositol phosphate accumulations were potentiated to varying degrees in PKC-depleted cultures whilst those evoked by carbachol and NaF were reduced and unchanged respectively.	Histamine	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	190-193
7902747-3	1993	Noradrenaline-, ATP-, histamine- and glutamate-evoked [3H]-inositol phosphate accumulations were potentiated to varying degrees in PKC-depleted cultures whilst those evoked by carbachol and NaF were reduced and unchanged respectively.	Glutamic Acid	37-46	C-X-C motif chemokine ligand 8	Homo sapiens	190-193
7691110-9	1993	Rhamnolipids and MEP were found to stimulate the copious release of IL-8, GM-CSF, and IL-6 from epithelial cells, in a steroid-sensitive fashion.	Steroids	119-126	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
8214944-4	1993	Therefore, we conducted a prospective study in order to investigate whether methylprednisolone (MP) pretreatment (30 mg/kg) could influence the appearance of IL-8 (a recently discovered cytokine with potent neutrophil-chemotactic activity) in the peripheral circulation.	Methylprednisolone	96-98	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
8413215-4	1993	A nuclear complex was induced in phorbol myristate acetate-treated Jurkat T cells which bound specifically to the kappa B site of the IL-8 promoter and was inhibited by addition of purified I kappa B alpha to the reaction mixture.	Tetradecanoylphorbol Acetate	33-58	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
8413215-10	1993	Antisense oligonucleotides to RelA, but not NFKB1, inhibited phorbol myristate acetate-induced IL-8 production in Jurkat T lymphocytes.	Oligonucleotides	10-26	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
8413215-10	1993	Antisense oligonucleotides to RelA, but not NFKB1, inhibited phorbol myristate acetate-induced IL-8 production in Jurkat T lymphocytes.	Tetradecanoylphorbol Acetate	61-86	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
8219478-8	1993	IL-8 was not influenced by GH or IGF-I, was slightly but not significantly increased by PTH(1-34) and was reduced by 1,25(OH)2D3 and 17 beta-oestradiol at supraphysiological doses.	beta-oestradiol	136-151	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8399143-7	1993	On the basis of the conservation of four cysteine residues, the two molecules are to be classified within the C-X-C chemokine family, including IL-8.	Cysteine	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
8103045-2	1993	We have previously demonstrated that a basic amino acid residue of interleukin (IL)-8, namely Arg-6, is critical for the binding of IL-8 to its receptor.	Amino Acids, Basic	39-55	C-X-C motif chemokine ligand 8	Homo sapiens	67-85
8103045-2	1993	We have previously demonstrated that a basic amino acid residue of interleukin (IL)-8, namely Arg-6, is critical for the binding of IL-8 to its receptor.	Amino Acids, Basic	39-55	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
8103045-2	1993	We have previously demonstrated that a basic amino acid residue of interleukin (IL)-8, namely Arg-6, is critical for the binding of IL-8 to its receptor.	Arginine	94-97	C-X-C motif chemokine ligand 8	Homo sapiens	67-85
8103045-2	1993	We have previously demonstrated that a basic amino acid residue of interleukin (IL)-8, namely Arg-6, is critical for the binding of IL-8 to its receptor.	Arginine	94-97	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
8103045-4	1993	To identify this key residue, we systematically mutated to Ala all acidic residues present on the ligand accessible surface of IL-8 receptor type A.	Alanine	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
8103045-7	1993	These data suggest that Lys-11 recruits a new and favorable interaction with IL-8 (analogous to that of IL-8 receptor type B with IL-8) or that the cavity created by mutating Asp-11 to Ala is particularly deleterious.	lys-11	24-30	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
8103045-7	1993	These data suggest that Lys-11 recruits a new and favorable interaction with IL-8 (analogous to that of IL-8 receptor type B with IL-8) or that the cavity created by mutating Asp-11 to Ala is particularly deleterious.	lys-11	24-30	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
8103045-7	1993	These data suggest that Lys-11 recruits a new and favorable interaction with IL-8 (analogous to that of IL-8 receptor type B with IL-8) or that the cavity created by mutating Asp-11 to Ala is particularly deleterious.	lys-11	24-30	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
7488352-1	1993	The 10 pivotal caries clinical studies employed in a recent meta-analysis to compare the anticaries efficacy of sodium fluoride (NaF) and sodium monofluorophosphate (MFP) dentifrices were subjected to a critical review.	Sodium Fluoride	112-127	C-X-C motif chemokine ligand 8	Homo sapiens	129-132
8142610-6	1993	However, PQ potentiated the production of IL-8 in the presence of 1 ng/ml of endotoxin (lipopolysaccharide, LPS).	Paraquat	9-11	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
7488354-1	1993	The comparison of the anticaries efficacy of dentifrices containing sodium fluoride (NaF) and sodium monofluorophosphate (SMFP) has recently been addressed through a meta-analysis of published head-to-head clinical trials.	Sodium Fluoride	68-83	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
8396851-5	1993	RESULTS: Significant quantities of interleukin-8 were produced by the tissue, and the data indicate that cervical explants from pregnant and nonpregnant women behave in a similar way when challenged by phorbol myristate acetate but that the postmenopausal cervix loses its capacity for interleukin-8 production.	Tetradecanoylphorbol Acetate	202-227	C-X-C motif chemokine ligand 8	Homo sapiens	35-48
8396851-6	1993	CONCLUSIONS: Human cervix is capable of producing large amounts of interleukin-8 in vitro, and it may be influenced by the steroid hormones.	Steroids	123-139	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
8396001-8	1993	LTB4, IL-8, and PLA2 levels were elevated in patients with NIP; LTB4 and PLA2 levels correlated with absolute neutrophil count, and IL-8 correlated with alveolar-arterial oxygen pressure difference.	Oxygen	171-177	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
8142610-0	1993	The pneumotoxicant paraquat induces IL-8 mRNA in human mononuclear cells and pulmonary epithelial cells.	Paraquat	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
8142610-3	1993	We have studied the effect of PQ on the expression of the neutrophil chemotactic cytokine, IL-8, by human peripheral blood mononuclear cells (PBMC).	Paraquat	30-32	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
8216423-8	1993	We confirmed that the majority of the neutrophil-stimulating activity was IL-8 by 3 different approaches: cross-desensitization experiments with IL-8, melanoma growth-stimulatory activity, and neutrophil-activating peptide 2, stimulation of calcium mobilization in cells transfected with the IL-8 receptor complementary DNA, and inhibition of the activity following pretreatment of the supernatants with an anti-IL-8 antibody.	Calcium	241-248	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
8142610-8	1993	Stimulation of IL-8 mRNA by PQ was suppressed by IL-4 and by free radical scavengers (dimethylsulfoxide, mannitol).	Paraquat	28-30	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
8142610-5	1993	While PQ did stimulate the appearance of IL-8 mRNA, no significant production of IL-8 protein was detected.	Paraquat	6-8	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
8142610-8	1993	Stimulation of IL-8 mRNA by PQ was suppressed by IL-4 and by free radical scavengers (dimethylsulfoxide, mannitol).	Dimethyl Sulfoxide	86-103	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
8142610-8	1993	Stimulation of IL-8 mRNA by PQ was suppressed by IL-4 and by free radical scavengers (dimethylsulfoxide, mannitol).	Mannitol	105-113	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
8142610-9	1993	Increased IL-8 expression by PQ was also observed in the human pulmonary epithelial cell line A549 indicating that the effect of PQ was not specific for PBMC.	Paraquat	29-31	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
8142610-9	1993	Increased IL-8 expression by PQ was also observed in the human pulmonary epithelial cell line A549 indicating that the effect of PQ was not specific for PBMC.	Paraquat	129-131	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
8142610-10	1993	These findings suggest that IL-8 might be involved in the pulmonary effects of PQ and that its production might be stimulated following an oxidative insult, and might clarify the pathogenetic mechanisms of adult respiratory distress syndrome (ARDS) or oxidant-induced pulmonary fibrosis.	Paraquat	79-81	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
8342895-9	1993	In addition, CSR-CSA cycle length correlated with LECT (r = 0.939, p &lt; 0.001).	Cyclosporine	17-20	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
8359798-7	1993	The alcohol-dependent control group and the normal volunteer controls had mean interleukin-8 concentrations of 106 +/- 28 pg/ml and 10 +/- 5 pg/ml, respectively.	Alcohols	4-11	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
8245177-1	1993	In human monocytes phorbol-12-myristate 13-acetate (PMA) did not induce IL-6 but it increased IL-1 beta and IL-8 mRNA levels.	Tetradecanoylphorbol Acetate	19-50	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
8245177-1	1993	In human monocytes phorbol-12-myristate 13-acetate (PMA) did not induce IL-6 but it increased IL-1 beta and IL-8 mRNA levels.	Tetradecanoylphorbol Acetate	52-55	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
8360485-9	1993	Exposure of the two melanoma cell lines in vitro to antisense oligonucleotides targeted against two different sites of human IL-8 mRNA-inhibited cell proliferation, colony formation in soft agar, and secretion of IL-8 protein into culture supernatant in a dose dependent fashion.	Oligonucleotides	62-78	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
8360485-9	1993	Exposure of the two melanoma cell lines in vitro to antisense oligonucleotides targeted against two different sites of human IL-8 mRNA-inhibited cell proliferation, colony formation in soft agar, and secretion of IL-8 protein into culture supernatant in a dose dependent fashion.	Oligonucleotides	62-78	C-X-C motif chemokine ligand 8	Homo sapiens	213-217
8345201-13	1993	Interestingly, in contrast to the regulation of monocyte-derived IL-8 by PGE2, PGE2 treatment of PMN failed to inhibit the generation of LPS-induced IL-8.	Dinoprostone	73-77	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
8345201-7	1993	Because PMN and monocytes share the same stem cell, and monocyte-derived IL-8 is regulated by prostaglandin E2 (PGE2), glucocorticoids (dexamethasone; DEX) and the T-Lymphocyte-derived IL-4, we postulated that PMN-derived IL-8 production may be regulated in a similar manner.	Dinoprostone	94-110	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
8345201-7	1993	Because PMN and monocytes share the same stem cell, and monocyte-derived IL-8 is regulated by prostaglandin E2 (PGE2), glucocorticoids (dexamethasone; DEX) and the T-Lymphocyte-derived IL-4, we postulated that PMN-derived IL-8 production may be regulated in a similar manner.	Dinoprostone	112-116	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
8345201-7	1993	Because PMN and monocytes share the same stem cell, and monocyte-derived IL-8 is regulated by prostaglandin E2 (PGE2), glucocorticoids (dexamethasone; DEX) and the T-Lymphocyte-derived IL-4, we postulated that PMN-derived IL-8 production may be regulated in a similar manner.	Dexamethasone	136-149	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
8345201-7	1993	Because PMN and monocytes share the same stem cell, and monocyte-derived IL-8 is regulated by prostaglandin E2 (PGE2), glucocorticoids (dexamethasone; DEX) and the T-Lymphocyte-derived IL-4, we postulated that PMN-derived IL-8 production may be regulated in a similar manner.	Dextromethorphan	151-154	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
8345201-11	1993	DEX and IL-4 in concentrations of 10(-6) M and 10 ng/ml resulted in maximal inhibition of LPS-induced PMN-derived IL-8, respectively.	Dextromethorphan	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
8345201-12	1993	Moreover, both DEX and IL-4 administration could be delayed 4 hr post-stimulation with LPS and result in significant suppression of PMN-derived IL-8.	Dextromethorphan	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
8394087-3	1993	Detailed analysis of phorbol 12-myristate 13-acetate-treated THP-1 cells showed an increased PBR expression and the rise came along with an increase of CD11a and CD11b antigens and a secretion of macrophagic cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-8.	Tetradecanoylphorbol Acetate	21-52	C-X-C motif chemokine ligand 8	Homo sapiens	287-291
8162335-0	1993	ETH615, a synthetic inhibitor of leukotriene biosynthesis and function, also inhibits the production of and biological responses towards interleukin-8.	ETH 615	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	137-150
8105874-3	1993	Apart from G-CSF, IL-8 was the weakest priming agent and was weaker than GM-CSF in priming arachidonic acid metabolism stimulated by calcium ionophore.	Arachidonic Acid	91-107	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
8105874-3	1993	Apart from G-CSF, IL-8 was the weakest priming agent and was weaker than GM-CSF in priming arachidonic acid metabolism stimulated by calcium ionophore.	Calcium	133-140	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
8162335-6	1993	These results further support the concept of a cytokine-leukotriene regulatory circuit and encourage the establishment of clinical trials testing the effect of ETH615 on inflammatory skin diseases, which are characterized by high levels of interleukin-8 and leukotriene B4 in lesional skin.	ETH 615	160-166	C-X-C motif chemokine ligand 8	Homo sapiens	240-253
8162335-0	1993	ETH615, a synthetic inhibitor of leukotriene biosynthesis and function, also inhibits the production of and biological responses towards interleukin-8.	Leukotrienes	33-44	C-X-C motif chemokine ligand 8	Homo sapiens	137-150
8162335-1	1993	ETH615 (4-(2-quinolylmethoxy)-N-(3-fluorobenzyl-phenyl-amino-methyl -4- benzoic-acid), a synthetic inhibitor of leukotriene B4 production and activities, was tested for its effect on the production of and biological responses towards human interleukin-8.	ETH 615	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	240-253
8162335-2	1993	We found that ETH615 inhibits lipopolysaccharide-induced (LPS-induced) expression of interleukin-8 messenger-RNA (mRNA) and interleukin-8 production in human peripheral blood mononuclear cells.	ETH 615	14-20	C-X-C motif chemokine ligand 8	Homo sapiens	85-98
8162335-2	1993	We found that ETH615 inhibits lipopolysaccharide-induced (LPS-induced) expression of interleukin-8 messenger-RNA (mRNA) and interleukin-8 production in human peripheral blood mononuclear cells.	ETH 615	14-20	C-X-C motif chemokine ligand 8	Homo sapiens	124-137
8162335-3	1993	We also observed that ETH615 completely inhibited interleukin-8 as well as leukotriene B4 directed chemotaxis of human neutrophils in a dose-dependent manner.	ETH 615	22-28	C-X-C motif chemokine ligand 8	Homo sapiens	50-63
8406585-0	1993	Interleukin-8 primes human neutrophils for enhanced superoxide anion production.	Superoxides	52-68	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
8406585-2	1993	In this study, we investigated the effect of recombinant human (rh) IL-8 on superoxide (O2-) production by neutrophils.	Superoxides	76-86	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
8406585-2	1993	In this study, we investigated the effect of recombinant human (rh) IL-8 on superoxide (O2-) production by neutrophils.	Superoxides	88-90	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
8406585-5	1993	Recombinant human IL-8 increased both the maximal rate and the total O2- production, but did not prolong the response to FMLP.	Superoxides	69-71	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
8335925-7	1993	The levels of MCP-1 and IL-8 protein from mixed lymphocyte reaction supernatants as measured by specific ELISA were positively correlated with the proliferative response as measured by [3H]TdR uptake.	Tritium	186-188	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
8335897-3	1993	In this study we tested the hypothesis that RPM-mediated therapeutic effects on accelerated rejection may be linked to decreased expression of protein encoded by gro/melanoma-growth stimulatory activity gene (KC) and macrophage inflammatory protein-2 (MIP-2) genes, the operational rat homologues of the human intercrine-alpha cytokines with proinflammatory IL-8-like neutrophil activation/chemotactic properties.	Sirolimus	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	358-362
8346230-0	1993	Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8.	Heparitin Sulfate	11-26	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
8346230-0	1993	Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8.	Heparin	30-37	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
8346230-1	1993	The interaction of interleukin 8 (IL-8) with heparin was studied by using synthetic IL-8 analogs with C- and N-terminal truncations.	Heparin	45-52	C-X-C motif chemokine ligand 8	Homo sapiens	19-32
8346230-1	1993	The interaction of interleukin 8 (IL-8) with heparin was studied by using synthetic IL-8 analogs with C- and N-terminal truncations.	Heparin	45-52	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
8346230-5	1993	When IL-8 was applied together with heparan sulfate, neutrophil chemotaxis in vitro was enhanced up to 4-fold, and the stimulus-dependent increase in cytosolic free Ca2+ increased markedly in both rate and peak value.	Heparitin Sulfate	36-51	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
8346230-10	1993	Taken together, these results suggest that heparan sulfate, which is present on the endothelial cell surface and in the basement membrane, may have a dual function in diapedesis, promotion of IL-8-dependent transmigration of neutrophils, and protection of the tissue microenvironment from damage by lytic enzymes released from the migrating cells.	Heparitin Sulfate	43-58	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
8335923-2	1993	For example, after exposure to the inflammatory particulate stimulus zymosan (or its derivative beta 1,3-glucan), monocyte/macrophages synthesize and release lysosomal hydrolases, mobilize arachadonic acid, and secrete cytokines such as TNF-alpha and IL-8.	Zymosan	69-76	C-X-C motif chemokine ligand 8	Homo sapiens	251-255
8360592-4	1993	RA differentially modulated the expression of interleukin-1 beta (IL-1 beta), IL-6, and IL-8 mRNAs depending on the inducing stimulus.	Tretinoin	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
8360592-5	1993	While phorbol myristate acetate-induced IL-1 beta and IL-8 mRNA expression was increased by RA (IL-6 could not be induced by this pathway in monocytes), IL-1 beta-induced expression of IL-1 beta and IL-8 was markedly reduced and IL-6 gene expression was almost completely suppressed.	Tetradecanoylphorbol Acetate	6-31	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
8393671-1	1993	NaF stimulation produces a strong dichlorofluorescin (DCFH) dye oxidation signal in HL-60 and PLB-985 human myeloid leukemia cells.	2',7'-dichlorofluorescein	34-52	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8393671-1	1993	NaF stimulation produces a strong dichlorofluorescin (DCFH) dye oxidation signal in HL-60 and PLB-985 human myeloid leukemia cells.	DCFH	54-58	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8393671-4	1993	NaF-stimulated DCFH oxidation appears to occur via a pathway that is distinct from respiratory burst oxidant-mediated DCFH oxidation.	DCFH	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8335897-11	1993	In contrast, the allografts from RPM-treated hosts showed essentially no neutrophil infiltration and minor, focal staining for IL-8 and IFN-gamma.	Sirolimus	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
8397092-2	1993	Histamine (EC50 6.5 microM), bradykinin (EC50 9.7 nM), carbachol (EC50 10 microM), substance P and NaF all produced concentration dependent [3H]inositol phosphate formation in these cells.	Tritium	141-143	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
8397092-2	1993	Histamine (EC50 6.5 microM), bradykinin (EC50 9.7 nM), carbachol (EC50 10 microM), substance P and NaF all produced concentration dependent [3H]inositol phosphate formation in these cells.	Inositol Phosphates	144-162	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
8335897-13	1993	It also documents a novel effect of RPM in vivo, which results in the suppression of intragraft IL-8-like and CTL-dependent mRNA/protein production and diminished neutrophil infiltration; these may contribute to the striking efficacy of RPM therapy in sensitized graft recipients.	Sirolimus	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
8335897-13	1993	It also documents a novel effect of RPM in vivo, which results in the suppression of intragraft IL-8-like and CTL-dependent mRNA/protein production and diminished neutrophil infiltration; these may contribute to the striking efficacy of RPM therapy in sensitized graft recipients.	Sirolimus	237-240	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
8335079-6	1993	Furthermore, native IL-8 was found to specifically bind CsA, whereas biologically inactive analogs of CsA were not bound by IL-8.	Cyclosporine	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
8319811-0	1993	Calcium ionophore A23187 induces interleukin-8 gene expression and protein secretion in human monocytic cells.	Calcium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	33-46
8335079-7	1993	Putative binding sites for CsA on IL-8 could be identified on the basis of structural similarities between IL-8 and cyclophilin.	Cyclosporine	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
8319811-0	1993	Calcium ionophore A23187 induces interleukin-8 gene expression and protein secretion in human monocytic cells.	Calcimycin	18-24	C-X-C motif chemokine ligand 8	Homo sapiens	33-46
8335079-7	1993	Putative binding sites for CsA on IL-8 could be identified on the basis of structural similarities between IL-8 and cyclophilin.	Cyclosporine	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
8335079-9	1993	We conclude that the specific binding of CsA to IL-8 may explain some of the anti-inflammatory effects of CsA.	Cyclosporine	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
8319811-3	1993	Bacterial lipopolysaccharide endotoxin (LPS) or phorbol myristate acetate (PMA) alone induced suboptimal expression as assessed by Northern blotting; however, preincubation of cells with PMA followed by endotoxin induced much higher levels of IL-8 mRNA.	lipopolysaccharide endotoxin	10-38	C-X-C motif chemokine ligand 8	Homo sapiens	243-247
8391481-0	1993	Functions of interleukin-8 are mediated through thiol group(s) of IL-8 receptor in human polymorphonuclear neutrophils.	Sulfhydryl Compounds	48-53	C-X-C motif chemokine ligand 8	Homo sapiens	13-26
8319811-3	1993	Bacterial lipopolysaccharide endotoxin (LPS) or phorbol myristate acetate (PMA) alone induced suboptimal expression as assessed by Northern blotting; however, preincubation of cells with PMA followed by endotoxin induced much higher levels of IL-8 mRNA.	Tetradecanoylphorbol Acetate	48-73	C-X-C motif chemokine ligand 8	Homo sapiens	243-247
8335079-9	1993	We conclude that the specific binding of CsA to IL-8 may explain some of the anti-inflammatory effects of CsA.	Cyclosporine	106-109	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
8319811-3	1993	Bacterial lipopolysaccharide endotoxin (LPS) or phorbol myristate acetate (PMA) alone induced suboptimal expression as assessed by Northern blotting; however, preincubation of cells with PMA followed by endotoxin induced much higher levels of IL-8 mRNA.	Tetradecanoylphorbol Acetate	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	243-247
8391481-0	1993	Functions of interleukin-8 are mediated through thiol group(s) of IL-8 receptor in human polymorphonuclear neutrophils.	Sulfhydryl Compounds	48-53	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
8391481-1	1993	Effects of 5,5"-dithio-bis(2-nitrobenzoic acid) on IL-8 receptor.	Dithionitrobenzoic Acid	11-47	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
8319811-3	1993	Bacterial lipopolysaccharide endotoxin (LPS) or phorbol myristate acetate (PMA) alone induced suboptimal expression as assessed by Northern blotting; however, preincubation of cells with PMA followed by endotoxin induced much higher levels of IL-8 mRNA.	Tetradecanoylphorbol Acetate	187-190	C-X-C motif chemokine ligand 8	Homo sapiens	243-247
8326131-5	1993	This antiserum was found to block, in a dose-dependent manner, 1) zymosan-induced neutrophil chemotaxis, 2) C5a-induced enzyme release from neutrophils, and 3) C5a-induced cytokine production (IL-6 and IL-8) from human monocytes in vitro.	Zymosan	66-73	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
8319811-4	1993	Incubation of the cells with the calcium ionophore A23187 resulted in consistent increased IL-8 gene expression comparable to that of cells treated with endotoxin alone.	Calcium	33-40	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
8319811-4	1993	Incubation of the cells with the calcium ionophore A23187 resulted in consistent increased IL-8 gene expression comparable to that of cells treated with endotoxin alone.	Calcimycin	51-57	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
8319811-5	1993	In addition to inducing IL-8 mRNA this calcium ionophore also induced IL-8 protein synthesis as assessed by immunofluorescence and secretion as detected by ELISA.	Calcium	39-46	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
8319811-5	1993	In addition to inducing IL-8 mRNA this calcium ionophore also induced IL-8 protein synthesis as assessed by immunofluorescence and secretion as detected by ELISA.	Calcium	39-46	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
8319811-6	1993	These results indicate that increases in intracellular calcium result in IL-8 gene expression and protein secretion.	Calcium	55-62	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
8391481-5	1993	Treatment of neutrophils with 5,5"-dithio-bis(2-nitrobenzoic acid), a thiol-specific modifier, at the concentrations of 0.4 mM and 1 mM reduced IL-8 binding ability and IL-8-induced migration of the cells by 45% and 65%, respectively.	Dithionitrobenzoic Acid	30-65	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
8391481-5	1993	Treatment of neutrophils with 5,5"-dithio-bis(2-nitrobenzoic acid), a thiol-specific modifier, at the concentrations of 0.4 mM and 1 mM reduced IL-8 binding ability and IL-8-induced migration of the cells by 45% and 65%, respectively.	Dithionitrobenzoic Acid	30-65	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
8391481-5	1993	Treatment of neutrophils with 5,5"-dithio-bis(2-nitrobenzoic acid), a thiol-specific modifier, at the concentrations of 0.4 mM and 1 mM reduced IL-8 binding ability and IL-8-induced migration of the cells by 45% and 65%, respectively.	Sulfhydryl Compounds	70-75	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
8391481-7	1993	All the evidence suggests that one or more critical thiol residues are located in the IL-8 binding site of the receptor which are indispensible for normal functions of IL-8.	Sulfhydryl Compounds	52-57	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
8391481-7	1993	All the evidence suggests that one or more critical thiol residues are located in the IL-8 binding site of the receptor which are indispensible for normal functions of IL-8.	Sulfhydryl Compounds	52-57	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
7686853-4	1993	In terms of maximal adherence inhibition, a rank list was found in the order of N-formyl-Met-Leu-Phe &gt; C5adesArg &gt; interleukin-8 &gt; C5a &gt; or = leukotriene B4, whereas platelet-activating factor, and lipopolysaccharide showed no inhibition.	N-Formylmethionine Leucyl-Phenylalanine	80-100	C-X-C motif chemokine ligand 8	Homo sapiens	121-134
8325620-5	1993	In contrast, moderate elevations in the levels of circulating interleukin-8 were seen in alcoholic cirrhosis (geometric mean = 93 ng/L; confidence interval = 40 to 213) and in alcoholic patients undergoing alcohol withdrawal (geometric mean = 137 ng/L; confidence interval = 72 to 259).	Alcohols	89-96	C-X-C motif chemokine ligand 8	Homo sapiens	62-75
8336074-3	1993	Lung giant cell carcinoma-derived chemotactic protein (LUCT)/IL-8 and fMet-Leu-Phe stimulate phosphorylation of a 64-kd protein (p64) in 32P-labeled human polymorphonuclear leukocytes (PMNs).	Phosphorus-32	137-140	C-X-C motif chemokine ligand 8	Homo sapiens	0-53
8336074-3	1993	Lung giant cell carcinoma-derived chemotactic protein (LUCT)/IL-8 and fMet-Leu-Phe stimulate phosphorylation of a 64-kd protein (p64) in 32P-labeled human polymorphonuclear leukocytes (PMNs).	Phosphorus-32	137-140	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
8323978-0	1993	Characterization of interleukin-8 receptors in human neutrophil membranes: regulation by guanine nucleotides.	Guanine Nucleotides	89-108	C-X-C motif chemokine ligand 8	Homo sapiens	20-33
8336074-3	1993	Lung giant cell carcinoma-derived chemotactic protein (LUCT)/IL-8 and fMet-Leu-Phe stimulate phosphorylation of a 64-kd protein (p64) in 32P-labeled human polymorphonuclear leukocytes (PMNs).	Phosphorus-32	137-140	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
8371232-5	1993	Before the treatment with colchicine, the neutrophil chemotactic and activating peptide, interleukin 8 (IL-8), was the major neutrophil chemotaxin within the SF.	Colchicine	26-36	C-X-C motif chemokine ligand 8	Homo sapiens	89-102
8371232-5	1993	Before the treatment with colchicine, the neutrophil chemotactic and activating peptide, interleukin 8 (IL-8), was the major neutrophil chemotaxin within the SF.	Colchicine	26-36	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
8371232-7	1993	Our data indicate that IL-8 was the major neutrophil chemotaxin in the SF, and that while the condition was alleviated with colchicine, the underlying disorder still existed, with the potential that discontinuance of the colchicine would result in the unrestrained action of the IL-8.	Colchicine	221-231	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
8503562-0	1993	Changes in cell population and tumor necrosis factor, interleukin-6, and interleukin-8 in malignant pleural effusions after treatment with intrapleural tetracycline.	Tetracycline	152-164	C-X-C motif chemokine ligand 8	Homo sapiens	73-86
8503562-8	1993	The results suggest that TC intrapleural injection induces the release of cytokines (IL-6 and TNF), which are markers of an inflammatory response, and releases IL-8, which attracts neutrophils into the pleural space, which may be the mechanism of the sclerosing effect of TC.	Tetracycline	25-27	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
8506955-7	1993	Stimulation of HPMC with combinations of IL-1 beta and TNF-alpha resulted in a synergistic increase in IL-8 release.	hydroxypropylmethylcellulose-lactose matrix	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
8506955-10	1993	These data demonstrate that HPMC synthesize IL-8 and that its release can be regulated as a result of induction of mRNA expression and de novo protein synthesis by other cytokines.	hydroxypropylmethylcellulose-lactose matrix	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
8347559-3	1993	The binding of 125I-labeled rabbit IL-8 to rabbit neutrophils was inhibited by unlabeled human IL-8 as well as rabbit IL-8 but not by another leucocyte chemotactic cytokine (chemokine), monocyte chemotactic and activating factor.	Iodine-125	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
8393062-4	1993	32P-Labeled PMNs were stimulated with LUCT/IL-8, fMLP, leukotriene B4, or C5a, and phosphorylated proteins were analyzed by two-dimensional electrophoresis and autoradiography.	Phosphorus-32	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
8396484-7	1993	The IP formation elicited by NaF was inhibited by PMA and octylindolactam V with a comparable IC50 value of 7.5 nM while was unchanged after ATP pretreatment.	Adenosine Triphosphate	141-144	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
8358540-18	1993	The EC50 value for NaF-stimulated IPn accumulation in control cells was 10.5 +/- 1.1 mm and the maximum response was 136 +/- 41% over basal after 20 min incubation.	isoamyl nitrite	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
8358540-19	1993	In histamine desensitized HeLa cells the EC50 value for NaF was 12.3 +/- 0.4 mM after 20 min stimulation,which was not significantly different from the value obtained in control cells.	Histamine	3-12	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
8358540-20	1993	The maximum NaF stimulated IPn formation in desensitized cells of 68 +/- 23% over basal occurred at 15 -20 mM and was significantly lower (P&lt;0.01) than that obtained in control cells.7.	isoamyl nitrite	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
8344709-5	1993	The intradermal injection of recombinant human (rh)IL-8 induced a dose-dependent accumulation of intravenously administered [111In]eosinophils into the skin sites over 4 hr.	Indium-111	125-130	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
8323978-3	1993	The present study characterizes IL-8 receptors in isolated PMN membrane fractions and shows direct regulation of these receptors by guanine nucleotides.	Guanine Nucleotides	132-151	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
8323978-9	1993	Treatment of membranes with the nonhydrolyzable analogs of GTP, GMP-PNP and GTP gamma S, inhibited the binding of [125I]IL-8.	Guanosine Triphosphate	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
8323978-9	1993	Treatment of membranes with the nonhydrolyzable analogs of GTP, GMP-PNP and GTP gamma S, inhibited the binding of [125I]IL-8.	Guanylyl Imidodiphosphate	64-71	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
8323978-9	1993	Treatment of membranes with the nonhydrolyzable analogs of GTP, GMP-PNP and GTP gamma S, inhibited the binding of [125I]IL-8.	Guanosine Triphosphate	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
8323978-10	1993	GMP-PNP decreased the affinity of the IL-8 receptor by approx.	Guanylyl Imidodiphosphate	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
8496597-0	1993	Differential action of cycloheximide and activation stimuli on transcription of tumor necrosis factor-alpha, IL-1 beta, IL-8, and P53 genes in human monocytes.	Cycloheximide	23-36	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
8323978-12	1993	These findings demonstrate that IL-8 receptors in PMN membranes are of high affinity and are convertible to a low-affinity state in the presence of guanine nucleotides, suggesting a direct role for G proteins in transmembrane signaling by this cytokine.	Guanine Nucleotides	148-167	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
8490165-8	1993	IL-8 synthesis after aspirin ingestion was inhibited by 90% (P &lt; .01) as compared with the preaspirin stimulation.	Aspirin	21-28	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8367538-5	1993	This effect was qualitatively similar to that induced by NaF, suggesting that quercetin may, like NaF, also inhibit type I photooxidations, which contribute to hemolysis.	Quercetin	78-87	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
8463247-1	1993	We have previously shown that the residues Glu4-Leu5-Arg6 (ELR) preceding the first cysteine at the N terminus of the 72-residue form of interleukin-8 (IL-8) are essential for receptor binding and neutrophil activation (Clark-Lewis, I., Schumacher, C., Baggiolini, M., and Moser, B.	Cysteine	84-92	C-X-C motif chemokine ligand 8	Homo sapiens	137-150
8490165-3	1993	In this study, we show that platelets activated with either adenosine-5"-diphosphate or epinephrine induce IL-8 secretion by EC.	Adenosine Diphosphate	60-84	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
8490165-3	1993	In this study, we show that platelets activated with either adenosine-5"-diphosphate or epinephrine induce IL-8 secretion by EC.	Epinephrine	88-99	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
8218944-6	1993	In competition experiments using [125I]-Gro beta-Tyr, unlabelled IL-8 and Gro beta-Tyr generated superposable displacement curves (IC50: 0.69 +/- 0.15 nM and 0.42 +/- 0.11 nM, respectively).	beta-tyr	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
8475106-1	1993	Amino acid deletion and mutagenesis experiments have indicated that the sequences Glu-Leu-Arg (ELR) preceding the first cysteine at the N terminus of interleukin 8 (IL-8) is required for receptor binding and neutrophil activation.	Glu-Leu-Arg	82-93	C-X-C motif chemokine ligand 8	Homo sapiens	150-163
8475106-1	1993	Amino acid deletion and mutagenesis experiments have indicated that the sequences Glu-Leu-Arg (ELR) preceding the first cysteine at the N terminus of interleukin 8 (IL-8) is required for receptor binding and neutrophil activation.	Glu-Leu-Arg	82-93	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
8475106-1	1993	Amino acid deletion and mutagenesis experiments have indicated that the sequences Glu-Leu-Arg (ELR) preceding the first cysteine at the N terminus of interleukin 8 (IL-8) is required for receptor binding and neutrophil activation.	Cysteine	120-128	C-X-C motif chemokine ligand 8	Homo sapiens	150-163
8475106-1	1993	Amino acid deletion and mutagenesis experiments have indicated that the sequences Glu-Leu-Arg (ELR) preceding the first cysteine at the N terminus of interleukin 8 (IL-8) is required for receptor binding and neutrophil activation.	Cysteine	120-128	C-X-C motif chemokine ligand 8	Homo sapiens	165-169
8494532-6	1993	Both IL8 (class I)- and TNF (class II)-stimulated Cl- efflux exhibited similar sensitivity to inhibition by different types of ion transport inhibitors [ethacrynic acid (EA), amiloride, 4-acetamido-4"-isothiocyanatostilbene-2,2"-disulfonic acid, anthracene-9-carboxylic acid, and 4-4"-diisothiocyanatostilbene-2,2"-disulfonic acid].	Ethacrynic Acid	153-168	C-X-C motif chemokine ligand 8	Homo sapiens	5-8
8494532-6	1993	Both IL8 (class I)- and TNF (class II)-stimulated Cl- efflux exhibited similar sensitivity to inhibition by different types of ion transport inhibitors [ethacrynic acid (EA), amiloride, 4-acetamido-4"-isothiocyanatostilbene-2,2"-disulfonic acid, anthracene-9-carboxylic acid, and 4-4"-diisothiocyanatostilbene-2,2"-disulfonic acid].	Ethacrynic Acid	170-172	C-X-C motif chemokine ligand 8	Homo sapiens	5-8
8494532-6	1993	Both IL8 (class I)- and TNF (class II)-stimulated Cl- efflux exhibited similar sensitivity to inhibition by different types of ion transport inhibitors [ethacrynic acid (EA), amiloride, 4-acetamido-4"-isothiocyanatostilbene-2,2"-disulfonic acid, anthracene-9-carboxylic acid, and 4-4"-diisothiocyanatostilbene-2,2"-disulfonic acid].	Amiloride	175-184	C-X-C motif chemokine ligand 8	Homo sapiens	5-8
8494532-6	1993	Both IL8 (class I)- and TNF (class II)-stimulated Cl- efflux exhibited similar sensitivity to inhibition by different types of ion transport inhibitors [ethacrynic acid (EA), amiloride, 4-acetamido-4"-isothiocyanatostilbene-2,2"-disulfonic acid, anthracene-9-carboxylic acid, and 4-4"-diisothiocyanatostilbene-2,2"-disulfonic acid].	4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid	186-244	C-X-C motif chemokine ligand 8	Homo sapiens	5-8
8494532-6	1993	Both IL8 (class I)- and TNF (class II)-stimulated Cl- efflux exhibited similar sensitivity to inhibition by different types of ion transport inhibitors [ethacrynic acid (EA), amiloride, 4-acetamido-4"-isothiocyanatostilbene-2,2"-disulfonic acid, anthracene-9-carboxylic acid, and 4-4"-diisothiocyanatostilbene-2,2"-disulfonic acid].	9-anthroic acid	246-274	C-X-C motif chemokine ligand 8	Homo sapiens	5-8
8494532-6	1993	Both IL8 (class I)- and TNF (class II)-stimulated Cl- efflux exhibited similar sensitivity to inhibition by different types of ion transport inhibitors [ethacrynic acid (EA), amiloride, 4-acetamido-4"-isothiocyanatostilbene-2,2"-disulfonic acid, anthracene-9-carboxylic acid, and 4-4"-diisothiocyanatostilbene-2,2"-disulfonic acid].	4-4"-diisothiocyanatostilbene-2,2"-disulfonic acid	280-330	C-X-C motif chemokine ligand 8	Homo sapiens	5-8
8386224-2	1993	Addition of NaF to intact cells resulted in an increase in the release of inositol phosphates (450% of control values; EC50 of approximately 8 mM).	Inositol Phosphates	74-93	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
8386224-3	1993	Inclusion of U-73122, an aminosteroid inhibitor of guanine nucleotide-regulated PIC activity in these cells, resulted in a dose-dependent inhibition of NaF-stimulated inositol lipid hydrolysis (IC50 of approximately 3.5 microM).	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
8386224-3	1993	Inclusion of U-73122, an aminosteroid inhibitor of guanine nucleotide-regulated PIC activity in these cells, resulted in a dose-dependent inhibition of NaF-stimulated inositol lipid hydrolysis (IC50 of approximately 3.5 microM).	Guanine Nucleotides	51-69	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
8386224-3	1993	Inclusion of U-73122, an aminosteroid inhibitor of guanine nucleotide-regulated PIC activity in these cells, resulted in a dose-dependent inhibition of NaF-stimulated inositol lipid hydrolysis (IC50 of approximately 3.5 microM).	inositol lipid	167-181	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
8386224-4	1993	When added to digitonin-permeabilized cells, NaF or guanosine-5"-O-thiotriphosphate (GTP gamma S) resulted in a three- and sevenfold enhancement, respectively, of inositol phosphate release.	Digitonin	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
8386224-4	1993	When added to digitonin-permeabilized cells, NaF or guanosine-5"-O-thiotriphosphate (GTP gamma S) resulted in a three- and sevenfold enhancement, respectively, of inositol phosphate release.	Guanosine 5'-O-(3-Thiotriphosphate)	85-96	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
8386224-4	1993	When added to digitonin-permeabilized cells, NaF or guanosine-5"-O-thiotriphosphate (GTP gamma S) resulted in a three- and sevenfold enhancement, respectively, of inositol phosphate release.	Inositol Phosphates	163-181	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
8386224-5	1993	In the combined presence of optimal concentrations of NaF and GTP gamma S, inositol phosphate release was less than additive, indicative of a common site of action.	Inositol Phosphates	75-93	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
8386224-6	1993	Inclusion of 2-5 mM concentrations of guanosine-5"-O-(2-thiodiphosphate) (GDP beta S) fully blocked phosphoinositide hydrolysis elicited by GTP gamma S, whereas that induced by NaF was partially inhibited (65%).	guanosine 5'-O-(2-thiodiphosphate)	74-84	C-X-C motif chemokine ligand 8	Homo sapiens	177-180
8386224-6	1993	Inclusion of 2-5 mM concentrations of guanosine-5"-O-(2-thiodiphosphate) (GDP beta S) fully blocked phosphoinositide hydrolysis elicited by GTP gamma S, whereas that induced by NaF was partially inhibited (65%).	Sulfur	83-84	C-X-C motif chemokine ligand 8	Homo sapiens	177-180
8386224-7	1993	However, preincubation of the cells with GDP beta S resulted in a greater reduction in the ability of NaF to stimulate inositol phosphate release (87% inhibition).	guanosine 5'-O-(2-thiodiphosphate)	41-51	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
8386224-7	1993	However, preincubation of the cells with GDP beta S resulted in a greater reduction in the ability of NaF to stimulate inositol phosphate release (87% inhibition).	Inositol Phosphates	119-137	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
8386224-8	1993	Both GTP gamma S and NaF-stimulated inositol phosphate release were inhibited by inclusion of 10 microM U-73122 (54-71%).	Inositol Phosphates	36-54	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
8386224-8	1993	Both GTP gamma S and NaF-stimulated inositol phosphate release were inhibited by inclusion of 10 microM U-73122 (54-71%).	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	104-111	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
8386224-10	1993	These results indicate that in SK-N-SH cells, little evidence exists for direct stimulation of PIC by NaF and that the majority of inositol phosphate release that occurs in the presence of NaF can be attributed to activation of Gp.	Inositol Phosphates	131-149	C-X-C motif chemokine ligand 8	Homo sapiens	189-192
8385495-1	1993	Sodium fluoride (NaF) alone below the concentration of 10 mM had no effect on platelet intracellular Ca2+ ([Ca2+]i).	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
8385495-4	1993	NaF was also effective in inhibiting thrombin- or U-46619-induced Mn2+ entry.	Manganese(2+)	66-70	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8385495-5	1993	This inhibitory effect of NaF on Ca2+ influx occurred after a lag of at least 30 s. However, Ca2+ influx induced by ionomycin-induced Ca2+ depletion or by thapsigargin, a Ca(2+)-ATPase inhibitor, was only partially suppressed by NaF treatment.	Ionomycin	116-125	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
8385495-5	1993	This inhibitory effect of NaF on Ca2+ influx occurred after a lag of at least 30 s. However, Ca2+ influx induced by ionomycin-induced Ca2+ depletion or by thapsigargin, a Ca(2+)-ATPase inhibitor, was only partially suppressed by NaF treatment.	Ionomycin	116-125	C-X-C motif chemokine ligand 8	Homo sapiens	229-232
8385495-5	1993	This inhibitory effect of NaF on Ca2+ influx occurred after a lag of at least 30 s. However, Ca2+ influx induced by ionomycin-induced Ca2+ depletion or by thapsigargin, a Ca(2+)-ATPase inhibitor, was only partially suppressed by NaF treatment.	Thapsigargin	155-167	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
8463247-1	1993	We have previously shown that the residues Glu4-Leu5-Arg6 (ELR) preceding the first cysteine at the N terminus of the 72-residue form of interleukin-8 (IL-8) are essential for receptor binding and neutrophil activation (Clark-Lewis, I., Schumacher, C., Baggiolini, M., and Moser, B.	Cysteine	84-92	C-X-C motif chemokine ligand 8	Homo sapiens	152-156
8463247-7	1993	The most potent were IL-8(6-72), with Arg6 at the N terminus, and IL-8,AAR(7-72) with N-terminal Ala4-Ala5 instead of Glu4-Leu5.	ala4-ala5	97-106	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
8104581-10	1993	NaF-treated plasma gave a significant underestimation of 3OHB.	3ohb	57-61	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8344717-8	1993	The optimal concentration in the chemotactic activity of CT/IL-8, equivalent to that of bacterial chemotactic peptide fMet-Leu-Phe (10 nM), was found to be 5 nM.	Leucine	123-126	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
8344717-8	1993	The optimal concentration in the chemotactic activity of CT/IL-8, equivalent to that of bacterial chemotactic peptide fMet-Leu-Phe (10 nM), was found to be 5 nM.	Phenylalanine	127-130	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
8458381-0	1993	Human peripheral blood eosinophils produce and release interleukin-8 on stimulation with calcium ionophore.	Calcium	89-96	C-X-C motif chemokine ligand 8	Homo sapiens	55-68
8458381-2	1993	Following in vitro culture of 99% pure eosinophils with calcium ionophore, released IL-8 was detectable by enzyme-linked immunosorbent assay in supernatants.	Calcium	56-63	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
8458381-4	1993	Furthermore, eosinophil production of IL-8 in the presence of calcium ionophore could be inhibited with the immunomodulating agent cyclosporin A and the protein synthesis inhibitor cycloheximide.	Calcium	62-69	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
8458381-4	1993	Furthermore, eosinophil production of IL-8 in the presence of calcium ionophore could be inhibited with the immunomodulating agent cyclosporin A and the protein synthesis inhibitor cycloheximide.	Cyclosporine	131-144	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
8458381-4	1993	Furthermore, eosinophil production of IL-8 in the presence of calcium ionophore could be inhibited with the immunomodulating agent cyclosporin A and the protein synthesis inhibitor cycloheximide.	Cycloheximide	181-194	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
8458381-5	1993	In addition, following stimulation of highly purified blood eosinophils with calcium ionophore, IL-8 mRNA was detectable after polymerase chain reaction amplification.	Calcium	77-84	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
8458381-6	1993	In comparison with other cells on stimulation with calcium ionophore, eosinophils produce about half as much IL-8 as neutrophils but significantly more than purified T cells.	Calcium	51-58	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
8458381-8	1993	Finally, following calcium ionophore stimulation blood eosinophils were shown to contain cytoplasmic IL-8 by employing a monoclonal antibody against IL-8 in conjunction with immunohistochemistry.	Calcium	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
8458381-8	1993	Finally, following calcium ionophore stimulation blood eosinophils were shown to contain cytoplasmic IL-8 by employing a monoclonal antibody against IL-8 in conjunction with immunohistochemistry.	Calcium	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
8464050-1	1993	The backbone dynamics of the cytokine interleukin-8, a symmetric homodimer of overall molecular mass 16 kDa, has been investigated at pH 5.2 by means of 15N relaxation measurements using heteronuclear two-dimensional inverse detected 1H-15N spectroscopy.	15n	153-156	C-X-C motif chemokine ligand 8	Homo sapiens	38-51
7681085-4	1993	Calcitriol was used to induce a high level of CD14 expression in the human monocyte-like cell line THP-1, resulting in enhanced responses of these cells to LPS-LBP complexes manifested by enhanced binding of LPS and a decrease in the amount of LPS needed to induce IL-8 release.	Calcitriol	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	265-269
8454590-6	1993	Incubation of neutrophils with sulfhydryl group-modifying reagents, N-ethylmaleimide and diazene dicarboxylic acid bis-N,N-dimethylamide (diamide), severely impaired the binding of 125I-IL-8 to neutrophils.	Ethylmaleimide	68-84	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
8454590-6	1993	Incubation of neutrophils with sulfhydryl group-modifying reagents, N-ethylmaleimide and diazene dicarboxylic acid bis-N,N-dimethylamide (diamide), severely impaired the binding of 125I-IL-8 to neutrophils.	Diamide	89-136	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
8454590-7	1993	Treatment with 0.8 mM N-ethylmaleimide and 0.4 mM diamide inhibit binding of 125I-IL-8 to the neutrophils by 62 and 60%, respectively.	Ethylmaleimide	22-38	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
8454590-7	1993	Treatment with 0.8 mM N-ethylmaleimide and 0.4 mM diamide inhibit binding of 125I-IL-8 to the neutrophils by 62 and 60%, respectively.	Diamide	50-57	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
8454590-11	1993	At a concentration of 0.4 mM, N-ethylmaleimide reduced the IL-8-induced (10 micrograms/ml) release of myeloperoxidase by 50%.	Ethylmaleimide	30-46	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
8454590-13	1993	Finally, N-ethylmaleimide severely affected the overall binding and total uptake of 125I-IL-8 to the neutrophils at 37 degrees C, a condition required for receptor-mediated internalization of the ligand and recycling of the receptor to the surface of neutrophils.	Ethylmaleimide	9-25	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
8464050-1	1993	The backbone dynamics of the cytokine interleukin-8, a symmetric homodimer of overall molecular mass 16 kDa, has been investigated at pH 5.2 by means of 15N relaxation measurements using heteronuclear two-dimensional inverse detected 1H-15N spectroscopy.	Hydrogen	234-236	C-X-C motif chemokine ligand 8	Homo sapiens	38-51
7680648-5	1993	Preincubation of the cells with cycloheximide "superinduced" the level of IL-8 mRNA stimulated by TNF alpha and IL-1 beta and RANTES mRNA stimulated by IL-1 beta, but decreased the expression of RANTES mRNA in response to TNF alpha.	Cycloheximide	32-45	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
8464050-1	1993	The backbone dynamics of the cytokine interleukin-8, a symmetric homodimer of overall molecular mass 16 kDa, has been investigated at pH 5.2 by means of 15N relaxation measurements using heteronuclear two-dimensional inverse detected 1H-15N spectroscopy.	15n	237-240	C-X-C motif chemokine ligand 8	Homo sapiens	38-51
8381770-8	1993	Inhibitory effects were obtained when GTP-binding protein functions were stimulated with sodium fluoride (NaF).	Sodium Fluoride	89-104	C-X-C motif chemokine ligand 8	Homo sapiens	106-109
8384238-4	1993	IFN-gamma also induced priming toward the stimulant NaF, a direct activator of guanine nucleotide regulatory proteins.	Guanine Nucleotides	79-97	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
8382247-2	1993	NaF and FMLP stimulated superoxide release from both groups of cells, but the response was attenuated in RA-differentiated cells.	Superoxides	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
8382840-6	1993	Using three different techniques--the E. coli killing assay (8 patients), the production of reactive oxygen as determined by cytochrome c reduction (7 patients) and chemiluminescence (8 patients)--a significant stimulation of neutrophil function at a concentration of 10 nm IL-8 was found in all test systems.	reactive oxygen	92-107	C-X-C motif chemokine ligand 8	Homo sapiens	274-278
8384226-6	1993	RESULTS: Nedocromil sodium inhibited the chemotactic response toward FMLP and NAF/IL-8 of GM-CSF primed eosinophils approximately 60% (inhibitory concentration of 50% [IC50] approximately 1 to 10 nmol/L), whereas these responses of IL-3 primed eosinophils was completely inhibited (IC50 approximately 1 nmol/L).	Nedocromil	9-26	C-X-C motif chemokine ligand 8	Homo sapiens	78-81
8384226-6	1993	RESULTS: Nedocromil sodium inhibited the chemotactic response toward FMLP and NAF/IL-8 of GM-CSF primed eosinophils approximately 60% (inhibitory concentration of 50% [IC50] approximately 1 to 10 nmol/L), whereas these responses of IL-3 primed eosinophils was completely inhibited (IC50 approximately 1 nmol/L).	Nedocromil	9-26	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
7679201-1	1993	Conflicting evidence has been reported concerning the mutagenicity of sodium fluoride (NaF), especially clastogenicity at concentrations of more than 1 mM.	Sodium Fluoride	70-85	C-X-C motif chemokine ligand 8	Homo sapiens	87-90
8382084-5	1993	Additionally, NaF and A23187 completely abrogated adenosine inhibition of fMLP-stimulated neutrophil adherence.	Adenosine	50-59	C-X-C motif chemokine ligand 8	Homo sapiens	14-17
8381837-4	1993	Bacterial toxins such as cholera toxin or pertussis toxin inhibited IL-8-induced chemokinetic activity, suggesting the involvement of guanine nucleotide-binding (G) proteins in IL-8 signal transduction in these cells.	Guanine Nucleotides	134-152	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
8381837-4	1993	Bacterial toxins such as cholera toxin or pertussis toxin inhibited IL-8-induced chemokinetic activity, suggesting the involvement of guanine nucleotide-binding (G) proteins in IL-8 signal transduction in these cells.	Guanine Nucleotides	134-152	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
8381837-9	1993	Various concentrations of IL-8 enhanced the binding of GTP-gamma 35 S to IANK cell membranes, which further indicates the coupling of G proteins to IL-8 receptors in IANK cells.	Guanosine Triphosphate	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
8381837-9	1993	Various concentrations of IL-8 enhanced the binding of GTP-gamma 35 S to IANK cell membranes, which further indicates the coupling of G proteins to IL-8 receptors in IANK cells.	Guanosine Triphosphate	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
8383457-10	1993	However, NaF and forskolin stimulation of cAMP was markedly decreased in the treated group.	Cyclic AMP	42-46	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
8441897-5	1993	Significantly higher amounts of alkali soluble fluoride were formed on the enamel from the 2% and 0.2% NaF solutions, as compared with the control.	Fluorides	47-55	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
8432783-6	1993	Cotreatment of chorion cells or decidual cells with IL-1 beta and actinomycin D or cycloheximide abrogated IL-8 production.	Dactinomycin	66-79	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
8432783-6	1993	Cotreatment of chorion cells or decidual cells with IL-1 beta and actinomycin D or cycloheximide abrogated IL-8 production.	Cycloheximide	83-96	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
8431115-4	1993	Steroids greatly reduced the clinical response to endotoxin and attenuated the appearance of tumor necrosis factor, IL-6, and IL-8 in the circulation.	Steroids	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
8473010-7	1993	Further observations revealed that, in human PMN, degradation of IL-8 mRNA is finely regulated, and that cycloheximide (CHX), an inhibitor of protein synthesis, super-induces the mRNA accumulation for IL-8 in a dose- and time-dependent manner.	Cycloheximide	105-118	C-X-C motif chemokine ligand 8	Homo sapiens	201-205
8473010-7	1993	Further observations revealed that, in human PMN, degradation of IL-8 mRNA is finely regulated, and that cycloheximide (CHX), an inhibitor of protein synthesis, super-induces the mRNA accumulation for IL-8 in a dose- and time-dependent manner.	Cycloheximide	120-123	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
8473010-7	1993	Further observations revealed that, in human PMN, degradation of IL-8 mRNA is finely regulated, and that cycloheximide (CHX), an inhibitor of protein synthesis, super-induces the mRNA accumulation for IL-8 in a dose- and time-dependent manner.	Cycloheximide	120-123	C-X-C motif chemokine ligand 8	Homo sapiens	201-205
8441897-6	1993	There was also a significant increase in the firmly bound fluoride after treatment with the neutral 2% NaF solution.	Fluorides	58-66	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
8418897-6	1993	Enzyme activity was markedly inhibited by NaF, not influenced by excess glycerophosphate and slightly attenuated by propranolol, an inhibitor of PA phosphohydrolase in other systems.	Propranolol	116-127	C-X-C motif chemokine ligand 8	Homo sapiens	42-45
8381283-0	1993	Studies on the regulatory mechanisms of interleukin-8 gene expression in resting and IFN-gamma-treated neutrophils: evidence on the capability of staurosporine of inducing the production of interleukin-8 by human neutrophils.	Staurosporine	146-159	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
8381283-0	1993	Studies on the regulatory mechanisms of interleukin-8 gene expression in resting and IFN-gamma-treated neutrophils: evidence on the capability of staurosporine of inducing the production of interleukin-8 by human neutrophils.	Staurosporine	146-159	C-X-C motif chemokine ligand 8	Homo sapiens	190-203
7524285-0	1993	L-arginine/nitric oxide pathway: a possible signal transduction mechanism for the regulation of the chemokine IL-8 in human mesangial cells.	Arginine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
7524285-0	1993	L-arginine/nitric oxide pathway: a possible signal transduction mechanism for the regulation of the chemokine IL-8 in human mesangial cells.	Nitric Oxide	11-23	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
8380724-0	1993	Interleukin-8-stimulated polyphosphoinositide hydrolysis in human peripheral blood lymphocytes.	Phosphatidylinositol Phosphates	25-45	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
8380724-1	1993	We have attempted to provide evidence for the production of inositol phosphate (IP) metabolites as an indication of specific receptor-mediated signal transduction in human peripheral blood lymphocytes (PBL) in response to interleukin-8 (IL-8).	Inositol Phosphates	60-78	C-X-C motif chemokine ligand 8	Homo sapiens	222-235
8380724-1	1993	We have attempted to provide evidence for the production of inositol phosphate (IP) metabolites as an indication of specific receptor-mediated signal transduction in human peripheral blood lymphocytes (PBL) in response to interleukin-8 (IL-8).	Inositol Phosphates	60-78	C-X-C motif chemokine ligand 8	Homo sapiens	237-241
8380724-1	1993	We have attempted to provide evidence for the production of inositol phosphate (IP) metabolites as an indication of specific receptor-mediated signal transduction in human peripheral blood lymphocytes (PBL) in response to interleukin-8 (IL-8).	Inositol Phosphates	80-82	C-X-C motif chemokine ligand 8	Homo sapiens	222-235
8380724-1	1993	We have attempted to provide evidence for the production of inositol phosphate (IP) metabolites as an indication of specific receptor-mediated signal transduction in human peripheral blood lymphocytes (PBL) in response to interleukin-8 (IL-8).	Inositol Phosphates	80-82	C-X-C motif chemokine ligand 8	Homo sapiens	237-241
8380724-4	1993	Compared with phytohemagglutinin (PHA), which stimulated an increase in IP metabolites and, specifically, IP3 by greater than threefold, human recombinant (hr) IL-8 (1 nmol/L) also stimulated an increase in IP metabolites, as measured by HPLC, and a greater than threefold increase in IP3.	Inositol 1,4,5-Trisphosphate	285-288	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
7901957-15	1993	We showed that mRNA for IL-8 could be expressed in highly purified T lymphocytes only upon stimulation with ionomycin and PHA or PMA and PHA, and to a lesser extent PMA and IL-2.	Ionomycin	108-117	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
8273591-1	1993	Several protein kinase inhibitors (PKIs) were investigated for their effects on IL-1 beta, TNF alpha and PMA-induced IL-8 production from human umbilical vein endothelial cells (HUVEC).	Tetradecanoylphorbol Acetate	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
7908198-4	1993	It was of interest to note that serum IL-8 levels were increased transiently after abstinence from alcohol in patients with alcoholic hepatitis.	Alcohols	99-106	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
8273591-3	1993	Staurosporine, a potent but non-specific inhibitor of protein kinases, inhibited PMA-induced (IC50 2 nM) but not IL-1 beta or TNF alpha (IC50 &gt; 200 nM) induced IL-8 production.	Staurosporine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
8443122-1	1993	Few known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA).	phorbol myristic acetate	128-152	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
8273591-5	1993	However, the macrolide protein kinase inhibitor geldanamycin (IC50 = 30 nM), but not the closely related analog herbimycin A (5-500 nM), inhibited IL-8 production by 60%.	geldanamycin	48-60	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
8273591-6	1993	Northern blot analysis of IL-8 mRNA revealed that staurosporine suppressed mRNA increase following stimulation by PMA but not by IL-1.	Staurosporine	50-63	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
8420495-11	1993	CONCLUSION: Based on these results, we speculate that, although IL-8 may exert a synergistic effect with C5a/C5a des Arg in the induction of transepidermal leukocyte chemotaxis, it constitutes a proinflammatory cytokine that is involved in the production of the persistent inflammatory changes characterized by a T-lymphocyte infiltration.	Arginine	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
8457524-1	1993	In the present study the effect of replacement of dietary fat by palm oil in the normal Western diet on the in vitro release of the inflammatory cytokines tumour necrosis factor (TNF), interleukin (IL)-6 and IL-8 was examined.	Palm Oil	65-73	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
7506142-8	1993	The release of tumour necrosis factor-alpha (TNF-alpha) initiates the release of interleukin-1 and interleukin-8, which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines, respectively.	Amines	185-191	C-X-C motif chemokine ligand 8	Homo sapiens	99-112
7514580-0	1993	Effect of tenoxicam and indomethacin on the chemotaxis induced by substance P and interleukin-8 on human monocytes and polymorphonuclear cells.	tenoxicam	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	82-95
7514580-0	1993	Effect of tenoxicam and indomethacin on the chemotaxis induced by substance P and interleukin-8 on human monocytes and polymorphonuclear cells.	Indomethacin	24-36	C-X-C motif chemokine ligand 8	Homo sapiens	82-95
8420406-9	1993	TNF, IL-6, and IL-8 in BAL fluid supernatant concentrations increased in a time and exposure-dependent fashion after zinc oxide welding fume exposure.	Zinc Oxide	117-127	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
8402812-6	1993	While the numerical difference in efficacy between NaF and SMFP measured between 5 and 10% (total DMFS) over a 2- to 3-year clinical period, this could be expected, on theoretical grounds, to propagate to substantially larger differences (e.g. 10-20%) over 10-20 years.	dmfs	98-102	C-X-C motif chemokine ligand 8	Homo sapiens	51-54
7514580-3	1993	We investigated in vitro the effect of two non-steroidal antiinflammatory drugs, tenoxicam and indomethacin, on the chemotactic effect of substance P and interleukin-8 at concentrations that can be reached in the synovial fluid of arthritic patients.	tenoxicam	81-90	C-X-C motif chemokine ligand 8	Homo sapiens	154-167
8443122-1	1993	Few known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA).	Tetradecanoylphorbol Acetate	154-157	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
7514580-3	1993	We investigated in vitro the effect of two non-steroidal antiinflammatory drugs, tenoxicam and indomethacin, on the chemotactic effect of substance P and interleukin-8 at concentrations that can be reached in the synovial fluid of arthritic patients.	Indomethacin	95-107	C-X-C motif chemokine ligand 8	Homo sapiens	154-167
8443122-1	1993	Few known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA).	Cyclosporine	245-258	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
8443122-1	1993	Few known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA).	Cyclosporine	260-263	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
8429521-6	1993	However, IL-8 production by neonatal CBMCs was down-regulated by dexamethasone, a glucocorticoid which is clinically administered to mothers to promote fetal lung maturity in preterm delivery.	cbmcs	37-42	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
8427047-1	1993	The anabolic effects of sodium fluoride (NaF) on trabecular bone mass in osteoporosis is now well established.	Sodium Fluoride	24-39	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
8429521-6	1993	However, IL-8 production by neonatal CBMCs was down-regulated by dexamethasone, a glucocorticoid which is clinically administered to mothers to promote fetal lung maturity in preterm delivery.	Dexamethasone	65-78	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
8461565-1	1993	The future of sodium fluoride (NaF), the most potent osteoblast stimulator known to man, is in the balance.	Sodium Fluoride	14-29	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
18475524-0	1993	The effect of inhibition of leukotriene synthesis on the activity of interleukin-8 and granulocyte-macrophage colony-stimulating factor.	Leukotrienes	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	69-82
18475524-1	1993	The cytokines interleukin-8 (IL-8) and granulocyte-macrophage colony-stimulating factor (GM-CSF) enhanced the extracellular release of arachidonate metabolites from ionophore-stimulated neutrophils by 145 +/- 10% (mean +/- S.E.M., n = 13) and 182 +/- 11% (n = 16), respectively.	Arachidonic Acid	135-147	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
18475524-1	1993	The cytokines interleukin-8 (IL-8) and granulocyte-macrophage colony-stimulating factor (GM-CSF) enhanced the extracellular release of arachidonate metabolites from ionophore-stimulated neutrophils by 145 +/- 10% (mean +/- S.E.M., n = 13) and 182 +/- 11% (n = 16), respectively.	Arachidonic Acid	135-147	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
18475524-3	1993	Neither inhibitor affected the upregulation of CD11b beta(2)-integrin expression or priming of superoxide generation stimulated by IL-8 and GM-CSF.	Superoxides	95-105	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
8216828-3	1993	Our findings demonstrate that PBMC adherent to either plastic or physiological surfaces in combination with an inflammatory agonist is both a potent and efficacious signal for the expression and production of the neutrophil chemotactic/activating cytokine, IL-8.	PBMC	30-34	C-X-C motif chemokine ligand 8	Homo sapiens	257-261
8380937-1	1993	Whereas we observed previously that concentrations of the lipoxygenase inhibitor nordihydroguaiaretic acid that inhibited leukotriene B4 release from lipopolysaccharide-stimulated human alveolar macrophages in vitro also inhibited subsequent interleukin-8 release, we hypothesized that leukotriene B4 release was required for the release of interleukin-8.	Masoprocol	81-106	C-X-C motif chemokine ligand 8	Homo sapiens	242-255
21043600-3	1993	Phorbol myristate acetate (PMA; a PKC activator), sodium fluoride (NaF; a putative G protein activator), ADP and collagen stimulated the uptake of [(45)Ca(2+)] by platelets in dose-dependent manners.	Sodium Fluoride	50-65	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
21043600-5	1993	PMA-stimulated and NaF-stimulated [(45)Ca(2+)] uptake was inhibited in concentration-dependent manners by the PKC inhibitor, staurosporine.	Staurosporine	125-138	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
8380937-0	1993	The effect of inhibition of leukotriene B4 release on lipopolysaccharide-induced production of neutrophil attractant/activation protein-1 (interleukin-8) by human alveolar macrophages.	Leukotriene B4	28-42	C-X-C motif chemokine ligand 8	Homo sapiens	139-152
8380937-1	1993	Whereas we observed previously that concentrations of the lipoxygenase inhibitor nordihydroguaiaretic acid that inhibited leukotriene B4 release from lipopolysaccharide-stimulated human alveolar macrophages in vitro also inhibited subsequent interleukin-8 release, we hypothesized that leukotriene B4 release was required for the release of interleukin-8.	Masoprocol	81-106	C-X-C motif chemokine ligand 8	Homo sapiens	341-354
1334090-13	1992	The enzyme was inhibited by sphingosine and chloropromazine, and less potently, by propranolol and NaF.	Sphingosine	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
8256463-5	1993	Fluorescent light intensity is, however, significantly increased, indicating an increased transcapillary diffusion of sodium fluorescein (NaF) as a marker for enhanced leakage of the capillaries in the early stage of the disease.	Fluorescein	118-136	C-X-C motif chemokine ligand 8	Homo sapiens	138-141
1334781-7	1992	IL-8 had apparent BCA, which was not so high as that of C5a.	alpha-bromocinnamaldehyde	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
1281554-5	1992	An IL-8 antisense oligonucleotide specifically blocked the production of monocyte-induced angiogenic activity.	Oligonucleotides	18-33	C-X-C motif chemokine ligand 8	Homo sapiens	3-7
1332845-2	1992	Pretreatment of pituitary cell cultures with NaF (a guanyl nucleotide binding protein activator, 10 mM, 3 h) also decreased subsequent GnRH-stimulated LH release, and in addition, provoked a decrease in GnRH receptor number, an increase in GnRH receptor affinity, reduction of GnRH-stimulated IP production to basal levels, and an increase in the amount of LH released in response to stimulation with the calcium ionophore A23187.	Luteinizing Hormone	151-153	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
1281615-4	1992	Repeat fluorescein angiograms 6 weeks after placing angiogenic doses of rIL-8 demonstrated significant regression (P = 0.01) of the vascularity present at 2 weeks, suggesting that IL-8 angiogenesis undergoes dynamic modulation similar to that normally seen in wound healing.	Fluorescein	7-18	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
1332845-2	1992	Pretreatment of pituitary cell cultures with NaF (a guanyl nucleotide binding protein activator, 10 mM, 3 h) also decreased subsequent GnRH-stimulated LH release, and in addition, provoked a decrease in GnRH receptor number, an increase in GnRH receptor affinity, reduction of GnRH-stimulated IP production to basal levels, and an increase in the amount of LH released in response to stimulation with the calcium ionophore A23187.	Luteinizing Hormone	357-359	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
1332845-2	1992	Pretreatment of pituitary cell cultures with NaF (a guanyl nucleotide binding protein activator, 10 mM, 3 h) also decreased subsequent GnRH-stimulated LH release, and in addition, provoked a decrease in GnRH receptor number, an increase in GnRH receptor affinity, reduction of GnRH-stimulated IP production to basal levels, and an increase in the amount of LH released in response to stimulation with the calcium ionophore A23187.	Calcium	405-412	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
1332845-2	1992	Pretreatment of pituitary cell cultures with NaF (a guanyl nucleotide binding protein activator, 10 mM, 3 h) also decreased subsequent GnRH-stimulated LH release, and in addition, provoked a decrease in GnRH receptor number, an increase in GnRH receptor affinity, reduction of GnRH-stimulated IP production to basal levels, and an increase in the amount of LH released in response to stimulation with the calcium ionophore A23187.	Calcimycin	423-429	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
1332845-6	1992	GnRH-stimulated LH release was inhibited immediately after NaF pretreatment (1 microM GnRH-stimulated LH release in NaF-pretreated cells was 65% of control levels).	Luteinizing Hormone	16-18	C-X-C motif chemokine ligand 8	Homo sapiens	59-62
1332845-6	1992	GnRH-stimulated LH release was inhibited immediately after NaF pretreatment (1 microM GnRH-stimulated LH release in NaF-pretreated cells was 65% of control levels).	Luteinizing Hormone	16-18	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
1332845-6	1992	GnRH-stimulated LH release was inhibited immediately after NaF pretreatment (1 microM GnRH-stimulated LH release in NaF-pretreated cells was 65% of control levels).	Luteinizing Hormone	102-104	C-X-C motif chemokine ligand 8	Homo sapiens	59-62
1332845-6	1992	GnRH-stimulated LH release was inhibited immediately after NaF pretreatment (1 microM GnRH-stimulated LH release in NaF-pretreated cells was 65% of control levels).	Luteinizing Hormone	102-104	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
1332845-8	1992	A23187-provoked LH release was enhanced immediately after NaF pretreatment (30 microM A23187-stimulated LH release in NaF-pretreated cells was 170% of control levels).	Calcimycin	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
1332845-8	1992	A23187-provoked LH release was enhanced immediately after NaF pretreatment (30 microM A23187-stimulated LH release in NaF-pretreated cells was 170% of control levels).	Calcimycin	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	118-121
1332845-8	1992	A23187-provoked LH release was enhanced immediately after NaF pretreatment (30 microM A23187-stimulated LH release in NaF-pretreated cells was 170% of control levels).	Luteinizing Hormone	16-18	C-X-C motif chemokine ligand 8	Homo sapiens	118-121
1332845-8	1992	A23187-provoked LH release was enhanced immediately after NaF pretreatment (30 microM A23187-stimulated LH release in NaF-pretreated cells was 170% of control levels).	Calcimycin	86-92	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
1332845-8	1992	A23187-provoked LH release was enhanced immediately after NaF pretreatment (30 microM A23187-stimulated LH release in NaF-pretreated cells was 170% of control levels).	Calcimycin	86-92	C-X-C motif chemokine ligand 8	Homo sapiens	118-121
1332845-8	1992	A23187-provoked LH release was enhanced immediately after NaF pretreatment (30 microM A23187-stimulated LH release in NaF-pretreated cells was 170% of control levels).	Luteinizing Hormone	104-106	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
1332845-8	1992	A23187-provoked LH release was enhanced immediately after NaF pretreatment (30 microM A23187-stimulated LH release in NaF-pretreated cells was 170% of control levels).	Luteinizing Hormone	104-106	C-X-C motif chemokine ligand 8	Homo sapiens	118-121
1332845-10	1992	Furthermore, both NaF and GnRH pretreatment still provoked a decrease in gonadotrope responsiveness when IP production was inhibited by the phospholipase C inhibitor U-73122.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	166-173	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
1292643-3	1992	Levels of IL-8 were significantly correlated with the influx of neutrophils, plasma protein extravasation and with the PaO2/FiO2 ratio.	pao2	119-123	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
1292643-3	1992	Levels of IL-8 were significantly correlated with the influx of neutrophils, plasma protein extravasation and with the PaO2/FiO2 ratio.	fio2	124-128	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
1331181-4	1992	DMSO was found to directly inhibit IL-8 expression at the level of transcription.	Dimethyl Sulfoxide	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
1331181-5	1992	Furthermore, this effect was not LPS-specific, in that IL-8 production was reduced by DMSO to a similar extent upon stimulation of blood with phytohemagglutinin, aggregated immune complexes, TNF, or IL-1 beta.	Dimethyl Sulfoxide	86-90	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
1331181-6	1992	Other oxygen radical scavengers that have been shown to inhibit OH.-dependent reactions (dimethyl thiourea, thiourea, mannitol, and ethanol) also inhibited IL-8 production.	Reactive Oxygen Species	6-20	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
1331181-0	1992	Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood.	Reactive Oxygen Species	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	46-59
1331181-6	1992	Other oxygen radical scavengers that have been shown to inhibit OH.-dependent reactions (dimethyl thiourea, thiourea, mannitol, and ethanol) also inhibited IL-8 production.	1,3-dimethylthiourea	89-106	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
1331181-2	1992	scavenger dimethyl sulfoxide (DMSO) was found to dose-dependently inhibit interleukin 8 (IL-8) production in LPS-stimulated human whole blood.	Dimethyl Sulfoxide	10-28	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
1331181-2	1992	scavenger dimethyl sulfoxide (DMSO) was found to dose-dependently inhibit interleukin 8 (IL-8) production in LPS-stimulated human whole blood.	Dimethyl Sulfoxide	10-28	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
1331181-6	1992	Other oxygen radical scavengers that have been shown to inhibit OH.-dependent reactions (dimethyl thiourea, thiourea, mannitol, and ethanol) also inhibited IL-8 production.	Thiourea	98-106	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
1331181-2	1992	scavenger dimethyl sulfoxide (DMSO) was found to dose-dependently inhibit interleukin 8 (IL-8) production in LPS-stimulated human whole blood.	Dimethyl Sulfoxide	30-34	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
1331181-2	1992	scavenger dimethyl sulfoxide (DMSO) was found to dose-dependently inhibit interleukin 8 (IL-8) production in LPS-stimulated human whole blood.	Dimethyl Sulfoxide	30-34	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
1331181-6	1992	Other oxygen radical scavengers that have been shown to inhibit OH.-dependent reactions (dimethyl thiourea, thiourea, mannitol, and ethanol) also inhibited IL-8 production.	Mannitol	118-126	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
1331181-3	1992	At a concentration of 1% (vol/vol), DMSO blocked IL-8 release by approximately 90% in the presence of 1 microgram/ml LPS at a 24-h time point, but did not affect cell viability or reduce the production of tumor necrosis factor (TNF), interleukin 6, or interleukin-1 beta (IL-1 beta).	Dimethyl Sulfoxide	36-40	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
1331181-6	1992	Other oxygen radical scavengers that have been shown to inhibit OH.-dependent reactions (dimethyl thiourea, thiourea, mannitol, and ethanol) also inhibited IL-8 production.	Ethanol	132-139	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
1331181-7	1992	Conversely, addition of H2O2 caused a dose-dependent stimulation of IL-8 release.	Hydrogen Peroxide	24-28	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
1331181-8	1992	These results provide evidence that reactive oxygen metabolites play an important role in the regulation of IL-8 production and suggest that reduction of IL-8 release may contribute to the beneficial effects of antioxidants in experimental models of inflammation and ischemia/reperfusion injury.	Oxygen	45-51	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
1382479-0	1992	Interleukin-8 and RANTES inhibit basophil histamine release induced with monocyte chemotactic and activating factor/monocyte chemoattractant peptide-1 and histamine releasing factor.	Histamine	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
1383321-3	1992	After pretreatment with IL-3, significant histamine release was observed with 10(-8) M and 10(-7) M IL-8 and 10(-7) M NAP-2, but not with the other peptides.	Histamine	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
1383321-4	1992	At higher concentrations (10(-6) M), however, all IL-8 analogs, as well as the unrelated cationic peptides poly-D-lysine, histone VS, and lysozyme, induced histamine release to variable degrees.	Histamine	156-165	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
1383321-8	1992	IL-8 and, to a lesser extent, NAP-2 led to a transient rise of cytosolic free calcium concentration ([Ca2+]i), which was independent of a preexposure to IL-3.	Calcium	78-85	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
1401924-6	1992	Maximum accumulation of IL-8 mRNA was observed after 6 h of incubation with LR, and the elevation persisted over 24 h. Inhibition of protein synthesis by cycloheximide resulted in superinduction of IL-8 mRNAs by LR.	Cycloheximide	154-167	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
1401924-6	1992	Maximum accumulation of IL-8 mRNA was observed after 6 h of incubation with LR, and the elevation persisted over 24 h. Inhibition of protein synthesis by cycloheximide resulted in superinduction of IL-8 mRNAs by LR.	Cycloheximide	154-167	C-X-C motif chemokine ligand 8	Homo sapiens	198-202
1401924-9	1992	Gel shift assays with oligonucleotides containing the consensus NF-kappa B binding sequences of the IL-8 and Ig kappa light chain genes showed enhanced binding activity in nuclear extracts from cells incubated with LR.	Oligonucleotides	22-38	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
1402020-4	1992	Thus, the increase was due to extra- and intracellular cooperative mobilization of Ca2+, as supported by the reduced effect of IL-8 on [Ca2+]i after quenching with Mn2+.	Manganese(2+)	164-168	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
1438244-7	1992	Treatment of membranes with digitonin resulted in the preferential solubilization of a single receptor species, corresponding to p44, that bound GRO alpha and NAP-2 with low affinity (Kd = 30 nM) and IL-8 with high affinity (Kd = 0.4 nM).	Digitonin	28-37	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
1438244-8	1992	Exposure of neutrophil membranes to 100 microM guanosine 5"-[gamma-thio]triphosphate led to a 75-fold increase of the Kd in approximately 60% of the IL-8 receptors.	Guanosine 5'-O-(3-Thiotriphosphate)	47-84	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
1438244-11	1992	These results demonstrate that human neutrophils bear two classes of receptors for GRO alpha, NAP-2, and IL-8 (p70 and p44) that may differ in their mode of interaction with GTP regulatory proteins.	Guanosine Triphosphate	174-177	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
1415104-6	1992	The tyrosylprotein sulfotransferase enzyme required Triton X-100, MnCl2 and 5"-AMP, and obtained optimum activity at pH 6.8 in the presence of 0.5% Triton X-100, 20 mM MnCl2, 50 mM NaF, and 2 mM 5"-AMP.	Octoxynol	52-64	C-X-C motif chemokine ligand 8	Homo sapiens	181-184
1382479-1	1992	The objective of this study was to investigate the effect of interleukin-8 (IL-8) and RANTES on basophil histamine release induced with monocyte chemoattractant peptide-1 (MCP-1) and crude histamine releasing factor (HRF).	Histamine	105-114	C-X-C motif chemokine ligand 8	Homo sapiens	61-74
1415104-6	1992	The tyrosylprotein sulfotransferase enzyme required Triton X-100, MnCl2 and 5"-AMP, and obtained optimum activity at pH 6.8 in the presence of 0.5% Triton X-100, 20 mM MnCl2, 50 mM NaF, and 2 mM 5"-AMP.	manganese chloride	66-71	C-X-C motif chemokine ligand 8	Homo sapiens	181-184
1415104-6	1992	The tyrosylprotein sulfotransferase enzyme required Triton X-100, MnCl2 and 5"-AMP, and obtained optimum activity at pH 6.8 in the presence of 0.5% Triton X-100, 20 mM MnCl2, 50 mM NaF, and 2 mM 5"-AMP.	Adenosine Monophosphate	76-82	C-X-C motif chemokine ligand 8	Homo sapiens	181-184
1382479-2	1992	IL-8 induced low levels of histamine release (8.5 +/- 0.5%) from basophils obtained from only six of 20 donors at high concentrations (10(-6) M).	Histamine	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
1415104-6	1992	The tyrosylprotein sulfotransferase enzyme required Triton X-100, MnCl2 and 5"-AMP, and obtained optimum activity at pH 6.8 in the presence of 0.5% Triton X-100, 20 mM MnCl2, 50 mM NaF, and 2 mM 5"-AMP.	Octoxynol	148-160	C-X-C motif chemokine ligand 8	Homo sapiens	181-184
1415104-6	1992	The tyrosylprotein sulfotransferase enzyme required Triton X-100, MnCl2 and 5"-AMP, and obtained optimum activity at pH 6.8 in the presence of 0.5% Triton X-100, 20 mM MnCl2, 50 mM NaF, and 2 mM 5"-AMP.	manganese chloride	168-173	C-X-C motif chemokine ligand 8	Homo sapiens	181-184
1415104-6	1992	The tyrosylprotein sulfotransferase enzyme required Triton X-100, MnCl2 and 5"-AMP, and obtained optimum activity at pH 6.8 in the presence of 0.5% Triton X-100, 20 mM MnCl2, 50 mM NaF, and 2 mM 5"-AMP.	Adenosine Monophosphate	195-201	C-X-C motif chemokine ligand 8	Homo sapiens	181-184
1382479-4	1992	However, both IL-8 and RANTES inhibited MCP-1 and HRF-induced histamine release from basophils dose-dependently at concentrations of 10(-9) to 10(-7) M. Basophils from all donors showed a significant inhibitory response (greater than 15%).	Histamine	62-71	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
1382479-9	1992	IL-8 inhibited histamine release induced with all three peaks of HRF.	Histamine	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
1382479-10	1992	The inhibition of histamine release by IL-8 was significantly higher in normal subjects than in allergic patients (59 +/- 9% versus 31 +/- 7%, P less than 0.05).	Histamine	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
1522134-6	1992	Treatment of amnion cells stimulated by IL-1 beta with cycloheximide resulted in increased IL-8 production, while incubation of IL-1 beta treated amnion cells with actinomycin D resulted in a concentration-dependent decrease in detectable amounts of IL-8.	Cycloheximide	55-68	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
1397489-9	1992	The enzyme shows a molecular weight of 57 kDa, is insensitive to NaF, hydrolyzes p-nitro-phenylphosphate and o-c-phenylphosphate; ATP, a-naphthyl-phosphate and beta-glycerolphosphate are also dephosphorylated.	o-c-phenylphosphate	109-128	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
1522134-6	1992	Treatment of amnion cells stimulated by IL-1 beta with cycloheximide resulted in increased IL-8 production, while incubation of IL-1 beta treated amnion cells with actinomycin D resulted in a concentration-dependent decrease in detectable amounts of IL-8.	Cycloheximide	55-68	C-X-C motif chemokine ligand 8	Homo sapiens	250-254
1383379-10	1992	IL-8 inhibited this IgE production without affecting IgM, IgG1, IgG2, IgG3, IgG4, or IgA production, whereas IFN-gamma, IFN-alpha, or prostaglandin E2 (PGE2) failed to do so.	Dinoprostone	152-156	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
1522134-6	1992	Treatment of amnion cells stimulated by IL-1 beta with cycloheximide resulted in increased IL-8 production, while incubation of IL-1 beta treated amnion cells with actinomycin D resulted in a concentration-dependent decrease in detectable amounts of IL-8.	Dactinomycin	164-177	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
1522134-6	1992	Treatment of amnion cells stimulated by IL-1 beta with cycloheximide resulted in increased IL-8 production, while incubation of IL-1 beta treated amnion cells with actinomycin D resulted in a concentration-dependent decrease in detectable amounts of IL-8.	Dactinomycin	164-177	C-X-C motif chemokine ligand 8	Homo sapiens	250-254
1381398-6	1992	In contrast, two other neutrophil agonists 1-0-alkyl-2-acetyl sn-glycero-3-phosphocholine and granulocyte-macrophage-CSF, which, like IL-8, are produced by activated HUVEC, as well as the leukocyte-derived chemoattractant leukotriene B4, exerted minimal inhibitory effects on adhesion.	1-0-alkyl-2-acetyl sn-glycero-3-phosphocholine	43-89	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
1381398-6	1992	In contrast, two other neutrophil agonists 1-0-alkyl-2-acetyl sn-glycero-3-phosphocholine and granulocyte-macrophage-CSF, which, like IL-8, are produced by activated HUVEC, as well as the leukocyte-derived chemoattractant leukotriene B4, exerted minimal inhibitory effects on adhesion.	Leukotriene B4	222-236	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
1325308-0	1992	Signal transduction pathways leading to the production of IL-8 by human monocytes are differentially regulated by dexamethasone.	Dexamethasone	114-127	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
1325308-3	1992	We have now examined the effect of dexamethasone on the LPS-induced and other signal transduction pathways leading to the production of IL-8 by human monocytes.	Dexamethasone	35-48	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
1325308-4	1992	Dexamethasone inhibited the production of IL-8 stimulated with a cyclic adenosine monophosphate analog or LPS.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
1325308-4	1992	Dexamethasone inhibited the production of IL-8 stimulated with a cyclic adenosine monophosphate analog or LPS.	Cyclic AMP	65-95	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
1325308-6	1992	These results suggest that the signal transduction pathways leading to the production of IL-8 by human monocytes are differentially regulated by dexamethasone.	Dexamethasone	145-158	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
1422951-1	1992	Clinical studies on the use of sodium fluoride (NaF) in osteoporotic patients have demonstrated increased spinal bone mass without a reduction in vertebral fracture incidence, and a trend towards reduced appendicular bone mass with an increase in peripheral fracture incidence.	Sodium Fluoride	31-46	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
1477297-5	1992	Taken together, these results suggest that the stimulation of the IL-8 or gro beta receptor evokes three similar responses, but that only the activation of the IL-8 receptor and not that of gro beta results in elevated CD11b expression and calcium mobilization in human neutrophils.	Calcium	240-247	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
1477297-5	1992	Taken together, these results suggest that the stimulation of the IL-8 or gro beta receptor evokes three similar responses, but that only the activation of the IL-8 receptor and not that of gro beta results in elevated CD11b expression and calcium mobilization in human neutrophils.	Calcium	240-247	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
1522234-5	1992	We now show that isolated human blood monocytes respond to such an oxygen stress with augmented production of IL-8.	Oxygen	67-73	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
1522234-11	1992	The association of anoxic preconditioning and oxygen stress with augmented production of monocyte-derived IL-8 support the potential role for ischemia-reperfusion and hyperoxia-induced IL-8 production in vivo, providing a possible mechanism for PMN migration/activation in disease states characterized by altered tissue oxygenation.	Oxygen	46-52	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
1522234-11	1992	The association of anoxic preconditioning and oxygen stress with augmented production of monocyte-derived IL-8 support the potential role for ischemia-reperfusion and hyperoxia-induced IL-8 production in vivo, providing a possible mechanism for PMN migration/activation in disease states characterized by altered tissue oxygenation.	Oxygen	46-52	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
1522286-0	1992	Distribution of fluoride in saliva and plaque fluid after a 0.048 mol/L NaF rinse.	Fluorides	16-24	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
1325836-10	1992	However, when the phosphatase inhibitors NaF and sodium orthovanadate were included in the assay systems, phosphatidic acid was detected in addition to diradylglycerol.	Phosphatidic Acids	106-123	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
1325836-10	1992	However, when the phosphatase inhibitors NaF and sodium orthovanadate were included in the assay systems, phosphatidic acid was detected in addition to diradylglycerol.	diarachidonyl diglyceride	152-167	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
1323612-0	1992	Recombinant tumor necrosis factor-alpha potentiates neutrophil degranulation in response to host defense cytokines neutrophil-activating peptide 2 and IL-8 by modulating intracellular cyclic AMP levels.	Cyclic AMP	184-194	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
1643627-4	1992	(a) IL-8 poly A+ mRNA was detected in 2 of 2 low grade astrocytomas, 1 of 2 anaplastic astrocytomas, and 6 of 6 glioblastomas.	Poly A	9-15	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
1358240-3	1992	The drugs sodium aurothiomalate, D-penicillamine and sulphasalazine were all able to modulate IL-8 mRNA synthesis in and protein secretion from endothelial cells.	Gold Sodium Thiomalate	10-31	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
1358240-3	1992	The drugs sodium aurothiomalate, D-penicillamine and sulphasalazine were all able to modulate IL-8 mRNA synthesis in and protein secretion from endothelial cells.	Penicillamine	33-48	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
1358240-3	1992	The drugs sodium aurothiomalate, D-penicillamine and sulphasalazine were all able to modulate IL-8 mRNA synthesis in and protein secretion from endothelial cells.	Sulfasalazine	53-67	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
1358240-5	1992	In endothelial cells, treatment with hydrocortisone led to a linear suppression of IL-8 production in concentrations ranging from 0.5 micrograms/ml up to 500 micrograms/ml.	Hydrocortisone	37-51	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
1358240-7	1992	By contrast, 5-aminosalicylic acid induced a threefold increase in the IL-8 release.	Mesalamine	13-34	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
1358240-8	1992	In peripheral blood mononuclear cells it was only possible to suppress the IL-8 production by hydrocortisone treatment.	Hydrocortisone	94-108	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
1326018-1	1992	The effect of protease inhibitors on the intracellular production of free radicals was investigated by measuring chemiluminescence (CL) elicited from phagocytosed luminol-bound microspheres (Lumispheres) in human neutrophils stimulated with formylmethionyl-leucyl-phenylalanine (fMLP), interleukin-8 (IL-8), phorbol 12-myristate 13-acetate, or diacylglycerol.	Free Radicals	69-82	C-X-C motif chemokine ligand 8	Homo sapiens	286-299
1326018-1	1992	The effect of protease inhibitors on the intracellular production of free radicals was investigated by measuring chemiluminescence (CL) elicited from phagocytosed luminol-bound microspheres (Lumispheres) in human neutrophils stimulated with formylmethionyl-leucyl-phenylalanine (fMLP), interleukin-8 (IL-8), phorbol 12-myristate 13-acetate, or diacylglycerol.	Free Radicals	69-82	C-X-C motif chemokine ligand 8	Homo sapiens	301-305
1326018-3	1992	Compared to control buffer without protease inhibitor, gabexate mesylate (322 micrograms/ml) caused about a 10-fold increase in intracellular CL in stimulated neutrophils, and ulinastatin (3100 U/ml) a twofold increase in neutrophils stimulated with fMLP or IL-8.	Gabexate	55-72	C-X-C motif chemokine ligand 8	Homo sapiens	258-262
1512465-0	1992	Interleukin-8 stimulates calcium transients and promotes epidermal cell proliferation.	Calcium	25-32	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
1512465-8	1992	Polyclonal anti-IL-8 antibody blocked IL-8-induced calcium changes and proliferation.	Calcium	51-58	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
1512465-8	1992	Polyclonal anti-IL-8 antibody blocked IL-8-induced calcium changes and proliferation.	Calcium	51-58	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
1392258-3	1992	A retrospective assessment was made of clinical data collected from our observations of 389 osteoporotics treated with fluoride 30 +/- 8 mg/day (mean +/- SD) (equivalent to 66 +/- 17 mg NaF/day) and calcium 1500 mg/day for 28 +/- 18 months.	Fluorides	119-127	C-X-C motif chemokine ligand 8	Homo sapiens	186-189
1323613-0	1992	Retinoic acid and phorbol ester synergistically up-regulate IL-8 expression and specifically modulate protein kinase C-epsilon in human skin fibroblasts.	Tretinoin	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
1323613-0	1992	Retinoic acid and phorbol ester synergistically up-regulate IL-8 expression and specifically modulate protein kinase C-epsilon in human skin fibroblasts.	Phorbol Esters	18-31	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
1323613-3	1992	TPA (as previously reported) and RA both induced IL-8 mRNA and protein in a time- and dose-dependent manner.	Tretinoin	33-35	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
1323613-4	1992	IL-8 mRNA induction by TPA (10 nM) was maximal (15-fold) within 6 h, and returned to baseline within 24 h of treatment, although maximal induction (10-fold) by RA (1 microM) did not occur until 24 h posttreatment.	Tretinoin	160-162	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
1323613-5	1992	Induction of IL-8 by TPA was blocked by 1-(5-isoquinolinyl-sulfonyl)-2-methylpiperazine, which inhibits PKC and cAMP-dependent protein kinases (PKA), but not by N-(2-ganidinoethyl)-5-isoquinoline sulfonamide, which preferentially inhibits PKA, consistent with the participation of PKC in the induction of IL-8 by TPA.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	40-87	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
1323613-5	1992	Induction of IL-8 by TPA was blocked by 1-(5-isoquinolinyl-sulfonyl)-2-methylpiperazine, which inhibits PKC and cAMP-dependent protein kinases (PKA), but not by N-(2-ganidinoethyl)-5-isoquinoline sulfonamide, which preferentially inhibits PKA, consistent with the participation of PKC in the induction of IL-8 by TPA.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	40-87	C-X-C motif chemokine ligand 8	Homo sapiens	305-309
1323613-5	1992	Induction of IL-8 by TPA was blocked by 1-(5-isoquinolinyl-sulfonyl)-2-methylpiperazine, which inhibits PKC and cAMP-dependent protein kinases (PKA), but not by N-(2-ganidinoethyl)-5-isoquinoline sulfonamide, which preferentially inhibits PKA, consistent with the participation of PKC in the induction of IL-8 by TPA.	n-(2-ganidinoethyl)-5-isoquinoline sulfonamide	161-207	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
1323613-6	1992	In contrast, induction of IL-8 by RA was inhibited by both 1-(5-isoquinoline sulfonamide and N-(2-gamidinoethyl)-5-isoquinoline sulfonamide, suggesting the participation of PKA in the induction of IL-8 by RA.	Tretinoin	34-36	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
1323613-6	1992	In contrast, induction of IL-8 by RA was inhibited by both 1-(5-isoquinoline sulfonamide and N-(2-gamidinoethyl)-5-isoquinoline sulfonamide, suggesting the participation of PKA in the induction of IL-8 by RA.	Tretinoin	34-36	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
1323613-6	1992	In contrast, induction of IL-8 by RA was inhibited by both 1-(5-isoquinoline sulfonamide and N-(2-gamidinoethyl)-5-isoquinoline sulfonamide, suggesting the participation of PKA in the induction of IL-8 by RA.	1-(5-isoquinoline sulfonamide	59-88	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
1323613-6	1992	In contrast, induction of IL-8 by RA was inhibited by both 1-(5-isoquinoline sulfonamide and N-(2-gamidinoethyl)-5-isoquinoline sulfonamide, suggesting the participation of PKA in the induction of IL-8 by RA.	1-(5-isoquinoline sulfonamide	59-88	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
1323613-6	1992	In contrast, induction of IL-8 by RA was inhibited by both 1-(5-isoquinoline sulfonamide and N-(2-gamidinoethyl)-5-isoquinoline sulfonamide, suggesting the participation of PKA in the induction of IL-8 by RA.	n-(2-gamidinoethyl)-5-isoquinoline sulfonamide	93-139	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
1323613-6	1992	In contrast, induction of IL-8 by RA was inhibited by both 1-(5-isoquinoline sulfonamide and N-(2-gamidinoethyl)-5-isoquinoline sulfonamide, suggesting the participation of PKA in the induction of IL-8 by RA.	n-(2-gamidinoethyl)-5-isoquinoline sulfonamide	93-139	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
1323613-6	1992	In contrast, induction of IL-8 by RA was inhibited by both 1-(5-isoquinoline sulfonamide and N-(2-gamidinoethyl)-5-isoquinoline sulfonamide, suggesting the participation of PKA in the induction of IL-8 by RA.	Tretinoin	205-207	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
1323613-8	1992	Induction of IL-8 by RA also did not appear to be mediated indirectly through induction of IL-1, because addition of IL-1R antagonist did not block IL-8 induction by RA.	Tretinoin	21-23	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
1323613-9	1992	RA and TPA added in combination synergistically enhanced expression of IL-8 mRNA, measured at 6 (2-fold) and 24 h (10-fold) posttreatment.	Tretinoin	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
1497091-6	1992	In addition, when neutrophils were treated with cycloheximide, there was evidence for "superinduction" of steady-state levels of IL-8 mRNA and inhibition of antigenic IL-8 production.	Cycloheximide	48-61	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
1497091-6	1992	In addition, when neutrophils were treated with cycloheximide, there was evidence for "superinduction" of steady-state levels of IL-8 mRNA and inhibition of antigenic IL-8 production.	Cycloheximide	48-61	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
1503884-2	1992	Interleukin-8, released from mononuclear cells that have been exposed to urate and other crystals, is a potent chemotaxin and activator of neutrophils.	Uric Acid	73-78	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
1639472-4	1992	IL-8 is detected by enzyme-linked immunosorbent assay within 2 h of stimulation, with steady a increase in its level through 72 h. Further studies demonstrated that LPS could serve as a primary stimulus for the expression of IL-8, since LPS challenge in the presence of cycloheximide resulted in superinduction of bone marrow mononuclear cell-derived IL-8 mRNA.	Cycloheximide	270-283	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
1639472-4	1992	IL-8 is detected by enzyme-linked immunosorbent assay within 2 h of stimulation, with steady a increase in its level through 72 h. Further studies demonstrated that LPS could serve as a primary stimulus for the expression of IL-8, since LPS challenge in the presence of cycloheximide resulted in superinduction of bone marrow mononuclear cell-derived IL-8 mRNA.	Cycloheximide	270-283	C-X-C motif chemokine ligand 8	Homo sapiens	225-229
1639472-4	1992	IL-8 is detected by enzyme-linked immunosorbent assay within 2 h of stimulation, with steady a increase in its level through 72 h. Further studies demonstrated that LPS could serve as a primary stimulus for the expression of IL-8, since LPS challenge in the presence of cycloheximide resulted in superinduction of bone marrow mononuclear cell-derived IL-8 mRNA.	Cycloheximide	270-283	C-X-C motif chemokine ligand 8	Homo sapiens	225-229
1506514-2	1992	Calcium uptake was measured by treatment of the model plaques with [45Ca]-CaCl2 solutions with or without NaF.	Calcium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	106-109
1612748-7	1992	IL-8 levels appeared to correlate significantly with lactate levels and inversely with leukocyte and platelet numbers and mean arterial pressure.	Lactic Acid	53-60	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
1644918-5	1992	Binding between NAP-1 and antibody is strong, since 8 M urea at neutral or alkaline pH did not release NAP-1.	Urea	56-60	C-X-C motif chemokine ligand 8	Homo sapiens	16-21
1644918-6	1992	However, at pH 2.0 in 9 M urea approximately 15% of the total NAP-1 could be dissociated from the complex.	Urea	26-30	C-X-C motif chemokine ligand 8	Homo sapiens	62-67
1634507-4	1992	By thin layer chromatography and reverse-phase high pressure liquid chromatography, we demonstrated that PAF synthesized by human PMN stimulated with IL-8 is heterogeneous: the 2-acetylated phospholipids having the biological and physicochemical characteristics of PAF include the 1-O-alkyl form, which is produced in large extent (51%), and the 1-acyl form (20%).	2-acetylated phospholipids	177-203	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
1634507-4	1992	By thin layer chromatography and reverse-phase high pressure liquid chromatography, we demonstrated that PAF synthesized by human PMN stimulated with IL-8 is heterogeneous: the 2-acetylated phospholipids having the biological and physicochemical characteristics of PAF include the 1-O-alkyl form, which is produced in large extent (51%), and the 1-acyl form (20%).	1-hexadecyl-2-acetyl-glycero-3-phosphocholine	281-284	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
1634507-4	1992	By thin layer chromatography and reverse-phase high pressure liquid chromatography, we demonstrated that PAF synthesized by human PMN stimulated with IL-8 is heterogeneous: the 2-acetylated phospholipids having the biological and physicochemical characteristics of PAF include the 1-O-alkyl form, which is produced in large extent (51%), and the 1-acyl form (20%).	alkyl	285-290	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
1325732-2	1992	In 0.5 mM external Ca2+, NaF inhibited PTH release and lowered the cAMP content by 50-70% of the effects attained with 3.0 mM Ca2+.	Cyclic AMP	67-71	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
1325732-4	1992	It seems likely that NaF activates the inhibitory G1-protein involved in the regulation of cAMP generation.	Cyclic AMP	91-95	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
1325732-6	1992	Inhibition of PTH release by NaF probably results from the combined effects on [Ca2+]i and cAMP content.	Cyclic AMP	91-95	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
1422225-6	1992	rhIL-8 was assessed for biological efficacy by three criteria: (a) ability to induce chemotaxis in human neutrophils, (b) ability to induce oxygen burst metabolism, and (c) ability to be recognized by purified rabbit antibody generated against monocyte-derived IL-8.	Oxygen	140-146	C-X-C motif chemokine ligand 8	Homo sapiens	2-6
1321178-0	1992	Protective effect of nedocromil sodium on the interleukin-1-induced production of interleukin-8 in human bronchial epithelial cells.	Nedocromil	21-38	C-X-C motif chemokine ligand 8	Homo sapiens	82-95
1321178-7	1992	Nedocromil sodium reduced the IL-1-induced release of IL-8 in a dose-dependent manner, but concentrations of the compounds, up to 10(-5) mol/L, did not affect the constitutive production of this cytokine.	Nedocromil	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
1613466-3	1992	Although these proteins copurified with MCP-1 and IL-8 on heparin-Sepharose, they could be separated by cation-exchange fast protein liquid chromatography and reverse-phase high-performance liquid chromatography.	Sepharose	66-75	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
1640174-2	1992	Pretreatment of neutrophils with cytochalasin B abolished the LAI effect of IL-8, suggesting a microfilament-dependent mechanism.	Cytochalasin B	33-47	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
1322442-2	1992	An increase in the cytosolic free calcium concentration ([Ca2+]i) was greater in IL-8T- than in IL-8M- or IL-8E-activated HNs, and IL-8T was more potent than either IL-8M or IL-8E in sequentially desensitizing the HNs to the effects of the other IL-8 forms.	Calcium	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	81-86
1322442-2	1992	An increase in the cytosolic free calcium concentration ([Ca2+]i) was greater in IL-8T- than in IL-8M- or IL-8E-activated HNs, and IL-8T was more potent than either IL-8M or IL-8E in sequentially desensitizing the HNs to the effects of the other IL-8 forms.	Calcium	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	131-136
1322442-2	1992	An increase in the cytosolic free calcium concentration ([Ca2+]i) was greater in IL-8T- than in IL-8M- or IL-8E-activated HNs, and IL-8T was more potent than either IL-8M or IL-8E in sequentially desensitizing the HNs to the effects of the other IL-8 forms.	Calcium	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
1322442-3	1992	IL-8 induced a time- and concentration-dependent (0.1-100 nM) increase in the production of inositol 1,4,5-trisphosphate (IP3) in HNs.	Inositol 1,4,5-Trisphosphate	92-120	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
1322442-3	1992	IL-8 induced a time- and concentration-dependent (0.1-100 nM) increase in the production of inositol 1,4,5-trisphosphate (IP3) in HNs.	Inositol 1,4,5-Trisphosphate	122-125	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
1322442-4	1992	U-73122 (1-[6-[[17 beta-3-methoxyestra-1,3,5(10)-trien-17- yl]amino]hexyl]-1H-pyrrole-2,5-dione), a potent inhibitor of phospholipase C-catalyzed events in HNs, suppressed IL-8-triggered IP3 production, increased [Ca2+]i and granule exocytosis in HNs.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
1322442-4	1992	U-73122 (1-[6-[[17 beta-3-methoxyestra-1,3,5(10)-trien-17- yl]amino]hexyl]-1H-pyrrole-2,5-dione), a potent inhibitor of phospholipase C-catalyzed events in HNs, suppressed IL-8-triggered IP3 production, increased [Ca2+]i and granule exocytosis in HNs.	1-[6-[[17 beta-3-methoxyestra-1,3,5(10)-trien-17- yl]amino]hexyl	9-73	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
1322442-4	1992	U-73122 (1-[6-[[17 beta-3-methoxyestra-1,3,5(10)-trien-17- yl]amino]hexyl]-1H-pyrrole-2,5-dione), a potent inhibitor of phospholipase C-catalyzed events in HNs, suppressed IL-8-triggered IP3 production, increased [Ca2+]i and granule exocytosis in HNs.	maleimide	75-95	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
1640174-3	1992	Interleukin-8 induced a rapid increase (less than or equal to 15 s) in the polymerization of actin filaments in human neutrophils that was blocked by pretreatment with cytochalasin B.	Cytochalasin B	168-182	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
1640174-7	1992	We suggest that the ability of IL-8 and certain other leukocyte agonists to regulate the actin polymer network of neutrophils may play an important role in adhesive interactions with the vascular endothelium.	Polymers	95-102	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
1591007-4	1992	In this study, we examine the role of amiloride for the regulation of AM-derived interleukin (IL)-8, tumor necrosis factor (TNF), IL-6, and IL-1 beta.	Amiloride	38-47	C-X-C motif chemokine ligand 8	Homo sapiens	81-99
18965453-2	1992	Uranium(VI) is selectively separated and/or pre-concentrated from a volume up to 20 ml on an activated silica gel microcolumn (2 x 40 mm) from a medium of 0.03M EDTA, 0.06M tartrate, and/or 0.05M NaF at pH = 9.3.	Uranium	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	196-199
1591007-5	1992	Amiloride in concentrations of 10(-4) to 10(-6) M, concentrations capable of being achieved in the distal airways via nebulization, were shown to inhibit lipopolysaccharide-stimulated, AM-derived IL-8 and TNF in both a time- and dose-dependent fashion.	Amiloride	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
1591007-6	1992	In addition, 5-(N,N-hexamethylene) amiloride hydrochloride, an amiloride analogue with specific sodium channel antiport inhibition, resulted in a similar dose-dependent suppression of lipopolysaccharide-stimulated, AM-derived IL-8 production.	5-(n,n-hexamethylene) amiloride hydrochloride	13-58	C-X-C motif chemokine ligand 8	Homo sapiens	226-230
1591007-6	1992	In addition, 5-(N,N-hexamethylene) amiloride hydrochloride, an amiloride analogue with specific sodium channel antiport inhibition, resulted in a similar dose-dependent suppression of lipopolysaccharide-stimulated, AM-derived IL-8 production.	Amiloride	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	226-230
1591007-7	1992	Furthermore, the suppressive effect of amiloride appeared to be at the level of mRNA for IL-8, TNF, IL-1 beta, and IL-6, whereas steady-state levels of beta-actin mRNA remained unaltered.	Amiloride	39-48	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
1597151-5	1992	Sodium fluoride (NaF)-stimulated IP accumulation was also inhibited by U-73122 (from 1539 +/- 132 dpm to 414 +/- 21 dpm) while LH release increased from 22.9 +/- 1.4% total cellular LH to 28.0 +/- 2.2%.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
1597151-5	1992	Sodium fluoride (NaF)-stimulated IP accumulation was also inhibited by U-73122 (from 1539 +/- 132 dpm to 414 +/- 21 dpm) while LH release increased from 22.9 +/- 1.4% total cellular LH to 28.0 +/- 2.2%.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	71-78	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
1597151-5	1992	Sodium fluoride (NaF)-stimulated IP accumulation was also inhibited by U-73122 (from 1539 +/- 132 dpm to 414 +/- 21 dpm) while LH release increased from 22.9 +/- 1.4% total cellular LH to 28.0 +/- 2.2%.	Luteinizing Hormone	127-129	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
1597151-9	1992	These results demonstrate that GnRH- as well as NaF-stimulated LH release can be uncoupled from IP production calling to question the role of IP3 as a second messenger for GnRH-stimulated LH release.	Luteinizing Hormone	63-65	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
1315831-8	1992	Lineweaver-Burk analysis of the kinetics of PIP kinase assayed in the presence of 0.03 to 0.7 mM ATP showed that 10 nM IL-8 increased the Vmax of the enzyme 38 to 70.5%, with no significant change in the apparent Km for ATP or for PIP.	Adenosine Triphosphate	97-100	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
1631484-3	1992	More fluoride was deposited on the enamel from the neutral 2% NaF solution than from the Duraphat treatment.	Fluorides	5-13	C-X-C motif chemokine ligand 8	Homo sapiens	62-65
1631484-7	1992	Duraphat-treated samples submerged in water after the exposure lost only about 50% of the deposited fluoride, whereas samples treated with 2% NaF are known to lose all their fluoride under similar circumstances, a condition which may be related to the favorable clinical effect of Duraphat.	Fluorides	174-182	C-X-C motif chemokine ligand 8	Homo sapiens	142-145
1631484-7	1992	Duraphat-treated samples submerged in water after the exposure lost only about 50% of the deposited fluoride, whereas samples treated with 2% NaF are known to lose all their fluoride under similar circumstances, a condition which may be related to the favorable clinical effect of Duraphat.	sodium fluoride topical preparation	281-289	C-X-C motif chemokine ligand 8	Homo sapiens	142-145
1593135-2	1992	Since binding inhibition tests indicated that three monoclonal antibodies (mAbs; BS-1, WS-4, WS-6) blocked the binding of 125I-labelled IL-8 to neutrophils, we tested an ELISA using these mAbs as primary antibodies, rabbit anti-IL-8 Ab as the secondary antibody, and alkaline phosphatase-labelled goat anti-rabbit Ab as the conjugate.	Tungsten	87-89	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
1593135-2	1992	Since binding inhibition tests indicated that three monoclonal antibodies (mAbs; BS-1, WS-4, WS-6) blocked the binding of 125I-labelled IL-8 to neutrophils, we tested an ELISA using these mAbs as primary antibodies, rabbit anti-IL-8 Ab as the secondary antibody, and alkaline phosphatase-labelled goat anti-rabbit Ab as the conjugate.	Tungsten	93-95	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
1315831-8	1992	Lineweaver-Burk analysis of the kinetics of PIP kinase assayed in the presence of 0.03 to 0.7 mM ATP showed that 10 nM IL-8 increased the Vmax of the enzyme 38 to 70.5%, with no significant change in the apparent Km for ATP or for PIP.	Adenosine Triphosphate	220-223	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
1315831-10	1992	The microfilament disrupter, cytochalasin b, inhibited IL-8 induced stimulation of PIP kinase.	Cytochalasin B	29-43	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
1398515-5	1992	Supernatants of TPA-stimulated Co cells contained the cytokines IL2, IL3, IL4 and IL8, whereas these cytokines were not detected in the supernatants of untreated cells.	Tetradecanoylphorbol Acetate	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
1578146-6	1992	IL-8 release was dependent on FMLP-induced de novo protein synthesis because it was inhibited by cycloheximide, was paralleled by enhanced expression of IL-8 mRNA and was potentiated from two- to sixfold after preincubation of PMN with cytochalasin B.	Cycloheximide	97-110	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
1578146-6	1992	IL-8 release was dependent on FMLP-induced de novo protein synthesis because it was inhibited by cycloheximide, was paralleled by enhanced expression of IL-8 mRNA and was potentiated from two- to sixfold after preincubation of PMN with cytochalasin B.	Cytochalasin B	236-250	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
1315244-4	1992	We show that 3 h pretreatment of pituitary cell cultures with 10 mM NaF (a G protein activator), resulted in decreased gonadotrope responsiveness to subsequent GnRH treatment (3 h, 100 nM; 34.4 +/- 1.6% vs. 23.4 +/- 1.5% of total cellular LH).	Luteinizing Hormone	239-241	C-X-C motif chemokine ligand 8	Homo sapiens	68-71
1315244-5	1992	NaF-provoked gonadotrope desensitization to GnRH also occurred in the presence of 3 mM EGTA and in cells which had been depleted of protein kinase C. Desensitization to GnRH did not occur in response to pretreatment with (Bu)2cAMP (8 h, 1 mM).	Egtazic Acid	87-91	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
1315244-5	1992	NaF-provoked gonadotrope desensitization to GnRH also occurred in the presence of 3 mM EGTA and in cells which had been depleted of protein kinase C. Desensitization to GnRH did not occur in response to pretreatment with (Bu)2cAMP (8 h, 1 mM).	(bu)2camp	221-230	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
1315244-8	1992	In contrast, 3 h NaF (10 mM) pretreatment enhanced responsiveness of the gonadotrope to the Ca2+ ionophore A23187 in a protein kinase C- and cAMP-dependent manner.	Calcimycin	107-113	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
1315244-8	1992	In contrast, 3 h NaF (10 mM) pretreatment enhanced responsiveness of the gonadotrope to the Ca2+ ionophore A23187 in a protein kinase C- and cAMP-dependent manner.	Cyclic AMP	141-145	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
1315244-10	1992	These data suggest that G protein activation by NaF provokes gonadotrope desensitization to GnRH stimulation by both decreasing receptor numbers and by uncoupling of the receptors from inositol phosphate production.	Inositol Phosphates	185-203	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
1556187-2	1992	We found that instillation of crocidolite asbestos into the pleural space of rabbits led to the appearance in pleural liquid of chemotactic activity for neutrophils, and that this chemotactic activity was inhibited significantly by a neutralizing antibody to human interleukin 8 (IL-8).	Asbestos, Crocidolite	30-50	C-X-C motif chemokine ligand 8	Homo sapiens	265-278
1569349-5	1992	The IL-8 elevation, however, was remarkably suppressed by infusion of a steroid into the mother to promote fetal lung maturation.	Steroids	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
1592440-0	1992	Molecular analysis of the inhibition of interleukin-8 production by dexamethasone in a human fibrosarcoma cell line.	Dexamethasone	68-81	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
1592440-1	1992	In order to analyse the effects of glucocorticoids on interleukin-8 (IL-8) production more precisely, we examined the effects of dexamethasone on IL-8 production at the molecular level in a human fibrosarcoma cell line, 8387, which IL-1 induces to express IL-8 messenger RNA (mRNA) and to secrete IL-8.	Dexamethasone	129-142	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
1592440-1	1992	In order to analyse the effects of glucocorticoids on interleukin-8 (IL-8) production more precisely, we examined the effects of dexamethasone on IL-8 production at the molecular level in a human fibrosarcoma cell line, 8387, which IL-1 induces to express IL-8 messenger RNA (mRNA) and to secrete IL-8.	Dexamethasone	129-142	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
1592440-1	1992	In order to analyse the effects of glucocorticoids on interleukin-8 (IL-8) production more precisely, we examined the effects of dexamethasone on IL-8 production at the molecular level in a human fibrosarcoma cell line, 8387, which IL-1 induces to express IL-8 messenger RNA (mRNA) and to secrete IL-8.	Dexamethasone	129-142	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
1592440-2	1992	Over a wide dose range, dexamethasone inhibited IL-8 production induced by IL-1 alpha stimulation.	Dexamethasone	24-37	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
1592440-3	1992	Northern blotting analysis showed that dexamethasone also inhibited the IL-8 mRNA accumulation in a similar dose-related manner.	Dexamethasone	39-52	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
1592440-4	1992	Nuclear run-off assay revealed that dexamethasone decreased the transcription of the IL-8 gene and the degree of inhibition of transcription correlated well with the inhibition of IL-8 production, suggesting that the action of glucocorticoids is mainly at the transcriptional level.	Dexamethasone	36-49	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
1551879-4	1992	We have studied, by monitoring the activation-dependent tryptophan fluorescence of transducin T alpha subunit, the pF (-log[F-]) and pH dependencies of the kinetics of activation and deactivation of T alpha GDP in the presence of NaF and aluminum or beryllium salts.	Guanosine Diphosphate	207-210	C-X-C motif chemokine ligand 8	Homo sapiens	230-233
1533644-4	1992	The addition of aluminium chloride to 15 microM reduced the concentration of NaF required for 50% inhibition to 0.76 +/- 0.21 mM (n = 10).	Aluminum Chloride	16-34	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
1556187-2	1992	We found that instillation of crocidolite asbestos into the pleural space of rabbits led to the appearance in pleural liquid of chemotactic activity for neutrophils, and that this chemotactic activity was inhibited significantly by a neutralizing antibody to human interleukin 8 (IL-8).	Asbestos, Crocidolite	30-50	C-X-C motif chemokine ligand 8	Homo sapiens	280-284
1315451-0	1992	Acquisition of alkali-soluble fluoride by enamel through treatment with NaF-containing toothpastes in vitro.	Fluorides	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
1592976-3	1992	This micro-analytical technique was used for investigation of the effects of dentifrice formulations containing NaF, xylitol, or NaF/xylitol on plaque acid metabolism.	plaque acid	144-155	C-X-C motif chemokine ligand 8	Homo sapiens	129-132
1315451-1	1992	The first aim of the present study was to examine if alkali-soluble fluoride (calcium fluoride-like material and adsorbed fluoride) forms when a NaF-containing toothpaste is applied on human enamel surface in vitro.	Fluorides	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	145-148
1315451-1	1992	The first aim of the present study was to examine if alkali-soluble fluoride (calcium fluoride-like material and adsorbed fluoride) forms when a NaF-containing toothpaste is applied on human enamel surface in vitro.	Calcium Fluoride	78-94	C-X-C motif chemokine ligand 8	Homo sapiens	145-148
1315451-1	1992	The first aim of the present study was to examine if alkali-soluble fluoride (calcium fluoride-like material and adsorbed fluoride) forms when a NaF-containing toothpaste is applied on human enamel surface in vitro.	Fluorides	86-94	C-X-C motif chemokine ligand 8	Homo sapiens	145-148
1315451-8	1992	The clinical effect of a NaF-containing toothpaste may thus well depend on an initial formation of alkali-soluble fluoride.	Fluorides	114-122	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
1347804-4	1992	Choriodecidual cells in culture produced substantial amounts of interleukin-8; release was inhibited by progesterone and stimulated by the antiprogestagen mifepristone.	Progesterone	104-116	C-X-C motif chemokine ligand 8	Homo sapiens	64-77
1347804-4	1992	Choriodecidual cells in culture produced substantial amounts of interleukin-8; release was inhibited by progesterone and stimulated by the antiprogestagen mifepristone.	Mifepristone	155-167	C-X-C motif chemokine ligand 8	Homo sapiens	64-77
1347804-6	1992	Since prostaglandin E and interleukin-8 have synergistic effects, we suggest that interleukin-8 activity is the final common step of prostaglandin and antiprogestagen action in parturition.	Prostaglandins E	6-21	C-X-C motif chemokine ligand 8	Homo sapiens	82-95
1347804-6	1992	Since prostaglandin E and interleukin-8 have synergistic effects, we suggest that interleukin-8 activity is the final common step of prostaglandin and antiprogestagen action in parturition.	Prostaglandins	6-19	C-X-C motif chemokine ligand 8	Homo sapiens	82-95
1546956-8	1992	GTP[35S] binding to the membranes was also stimulated by two IL-8-related cytokines, neutrophil-activating peptide 2 (NAP-2) and melanoma growth-stimulatory activity (gro/MGSA).	Guanosine Triphosphate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
1540395-2	1992	Phorbol 12-myristate 13-acetate (PMA), alpha-thrombin, and sodium fluoride (NaF), a direct G-protein activator, produced a rapid and time-dependent translocation of PKC from the cytosol to the membrane.	Tetradecanoylphorbol Acetate	0-31	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
1540395-2	1992	Phorbol 12-myristate 13-acetate (PMA), alpha-thrombin, and sodium fluoride (NaF), a direct G-protein activator, produced a rapid and time-dependent translocation of PKC from the cytosol to the membrane.	Sodium Fluoride	59-74	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
1540395-3	1992	Activation of PKC by brief pretreatment of human umbilical vein endothelial cell (HUVEC) monolayers with PMA resulted in the inhibition of NaF-induced inositol phosphate increases and attenuation of both alpha-thrombin- and NaF-activated increases in intracellular Ca2+ (Ca2+i).	Tetradecanoylphorbol Acetate	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	139-142
1540395-3	1992	Activation of PKC by brief pretreatment of human umbilical vein endothelial cell (HUVEC) monolayers with PMA resulted in the inhibition of NaF-induced inositol phosphate increases and attenuation of both alpha-thrombin- and NaF-activated increases in intracellular Ca2+ (Ca2+i).	Tetradecanoylphorbol Acetate	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	224-227
1540395-3	1992	Activation of PKC by brief pretreatment of human umbilical vein endothelial cell (HUVEC) monolayers with PMA resulted in the inhibition of NaF-induced inositol phosphate increases and attenuation of both alpha-thrombin- and NaF-activated increases in intracellular Ca2+ (Ca2+i).	Inositol Phosphates	151-169	C-X-C motif chemokine ligand 8	Homo sapiens	139-142
1540395-8	1992	Staurosporine, a potent PKC inhibitor, at concentrations that inhibited PKC-induced phosphorylation of histone-1, augmented both alpha-thrombin- and NaF-induced production of inositol phosphates but markedly inhibited alpha-thrombin-, NaF-, and A23187-induced PGI2 synthesis.	Staurosporine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	149-152
1540395-8	1992	Staurosporine, a potent PKC inhibitor, at concentrations that inhibited PKC-induced phosphorylation of histone-1, augmented both alpha-thrombin- and NaF-induced production of inositol phosphates but markedly inhibited alpha-thrombin-, NaF-, and A23187-induced PGI2 synthesis.	Staurosporine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	235-238
1540395-8	1992	Staurosporine, a potent PKC inhibitor, at concentrations that inhibited PKC-induced phosphorylation of histone-1, augmented both alpha-thrombin- and NaF-induced production of inositol phosphates but markedly inhibited alpha-thrombin-, NaF-, and A23187-induced PGI2 synthesis.	Inositol Phosphates	175-194	C-X-C motif chemokine ligand 8	Homo sapiens	149-152
1529797-0	1992	Interleukin-8 stimulates the formation of 15-hydroxy-eicosatetraenoic acid by human neutrophils in vitro.	15-hydroxy-eicosatetraenoic acid	42-74	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
1529797-1	1992	Interleukin-8 (IL-8), is a potent activator of polymorphonuclear leukocyte (PMN) functions including chemotaxis, superoxide anion production, and enzyme release and it is also chemotactic for lymphocytes.	Superoxides	113-129	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
1529797-1	1992	Interleukin-8 (IL-8), is a potent activator of polymorphonuclear leukocyte (PMN) functions including chemotaxis, superoxide anion production, and enzyme release and it is also chemotactic for lymphocytes.	Superoxides	113-129	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
1529797-2	1992	Additionally, it has recently been shown that IL-8 stimulates the formation of 5-lipoxygenase (LO) products of arachidonic acid (AA) by human PMNs.	Arachidonic Acid	111-127	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
1529797-5	1992	Then IL-8 was added in biologically relevant concentrations ranging from 0.1 to 100 ng/ml and incubation was carried out for 5 min at 37 degrees C. Lipids were then extracted from supernatants, and eicosanoids were determined by quantitative RP-HPLC.	Eicosanoids	198-209	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
1546956-3	1992	To examine whether IL-8 receptors are coupled to activation of guanine-nucleotide-binding proteins (G-proteins), we have investigated the influence of IL-8 on GTP hydrolysis by and guanosine 5"-[gamma-[35S]thio]triphosphate (GTP[35S]) binding to purified human neutrophil plasma membranes.	Guanosine Triphosphate	159-162	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
1546956-3	1992	To examine whether IL-8 receptors are coupled to activation of guanine-nucleotide-binding proteins (G-proteins), we have investigated the influence of IL-8 on GTP hydrolysis by and guanosine 5"-[gamma-[35S]thio]triphosphate (GTP[35S]) binding to purified human neutrophil plasma membranes.	Guanosine Triphosphate	159-162	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
1546956-7	1992	High-affinity binding of GTP[35S] to neutrophil plasma membranes was stimulated half-maximally and maximally (up to 5-fold) by IL-8 at about 10 nM and 100 nM respectively.	Guanosine Triphosphate	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
1546956-7	1992	High-affinity binding of GTP[35S] to neutrophil plasma membranes was stimulated half-maximally and maximally (up to 5-fold) by IL-8 at about 10 nM and 100 nM respectively.	Sulfur-35	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
1546956-8	1992	GTP[35S] binding to the membranes was also stimulated by two IL-8-related cytokines, neutrophil-activating peptide 2 (NAP-2) and melanoma growth-stimulatory activity (gro/MGSA).	Sulfur-35	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
1505106-4	1992	The results showed a significant increase in NAP-1 production by synovial fluid MC when compared to peripheral blood MC.	Methylcholanthrene	80-82	C-X-C motif chemokine ligand 8	Homo sapiens	45-50
1617494-2	1992	As the bioavailability of sodium fluoride (NaF) can be impaired by concomitant absorption of calcium, both drugs have to be ingested separately.	Sodium Fluoride	26-41	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
1617494-2	1992	As the bioavailability of sodium fluoride (NaF) can be impaired by concomitant absorption of calcium, both drugs have to be ingested separately.	Calcium	93-100	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
1732379-11	1992	The observed ability of dapsone to inhibit neutrophil chemotaxis under agarose to FMLP and interleukin-8 may also be explained by interference with integrin-mediated adherence required for motility in this assay system.	Dapsone	24-31	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
1547561-5	1992	When a combination of NaF and mannose was used, the blood glucose concentration was relatively stable but slightly higher than nonpreserved samples for the next 24 h. However, samples containing mannose were unsuitable for electrolyte analysis.	Glucose	58-65	C-X-C motif chemokine ligand 8	Homo sapiens	22-25
1547561-6	1992	We conclude that a combination of D-mannose and NaF may be a better preservative for blood glucose than either compound alone.	Glucose	91-98	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
1518180-7	1992	Inositol metabolism and Ca mobilization in response to thrombin, STA2, or NaF were also investigated in patient A,B, and impaired aggregation to A23187 in patient C. The responses were normal in patient A, suggested that CO activity did not affect them.	Inositol	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
1728298-0	1992	Regulation of human alveolar macrophage- and blood monocyte-derived interleukin-8 by prostaglandin E2 and dexamethasone.	Dinoprostone	85-101	C-X-C motif chemokine ligand 8	Homo sapiens	68-81
1309557-14	1992	Stimulated mesothelial cells also expressed an inducible mRNA transcript that hybridized with a specific oligonucleotide probe for human NAP-1/IL-8.	Oligonucleotides	105-120	C-X-C motif chemokine ligand 8	Homo sapiens	137-142
1309557-14	1992	Stimulated mesothelial cells also expressed an inducible mRNA transcript that hybridized with a specific oligonucleotide probe for human NAP-1/IL-8.	Oligonucleotides	105-120	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
1729366-7	1992	Metabolically labeled IL-1 beta-stimulated chondrocytes synthesize IL-8 de novo, which comigrates on SDS-PAGE with IL-8 produced by synovial fibroblasts.	Sodium Dodecyl Sulfate	101-104	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
1728298-0	1992	Regulation of human alveolar macrophage- and blood monocyte-derived interleukin-8 by prostaglandin E2 and dexamethasone.	Dexamethasone	106-119	C-X-C motif chemokine ligand 8	Homo sapiens	68-81
1728298-4	1992	In this investigation, we describe the effects of prostaglandin E2 (PGE2) and dexamethasone (Dex) on IL-8 mRNA and protein expression from lipopolysaccharide (LPS)-treated human peripheral blood monocytes (PBM) and alveolar macrophages (AM).	Dinoprostone	50-66	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
1728298-4	1992	In this investigation, we describe the effects of prostaglandin E2 (PGE2) and dexamethasone (Dex) on IL-8 mRNA and protein expression from lipopolysaccharide (LPS)-treated human peripheral blood monocytes (PBM) and alveolar macrophages (AM).	Dinoprostone	68-72	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
1728298-4	1992	In this investigation, we describe the effects of prostaglandin E2 (PGE2) and dexamethasone (Dex) on IL-8 mRNA and protein expression from lipopolysaccharide (LPS)-treated human peripheral blood monocytes (PBM) and alveolar macrophages (AM).	Dexamethasone	78-91	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
1728298-4	1992	In this investigation, we describe the effects of prostaglandin E2 (PGE2) and dexamethasone (Dex) on IL-8 mRNA and protein expression from lipopolysaccharide (LPS)-treated human peripheral blood monocytes (PBM) and alveolar macrophages (AM).	Dexamethasone	93-96	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
1728298-5	1992	We demonstrate the dose-dependent suppression of IL-8 from LPS-stimulated PBM by PGE2.	Dinoprostone	81-85	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
1728298-6	1992	Treatment of stimulated PBM with 10(-6) M PGE2 resulted in maximal inhibition, causing 60% suppression of both IL-8 mRNA and extracellular protein levels.	pbm	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
1728298-6	1992	Treatment of stimulated PBM with 10(-6) M PGE2 resulted in maximal inhibition, causing 60% suppression of both IL-8 mRNA and extracellular protein levels.	Dinoprostone	42-46	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
1728298-8	1992	Treatment of LPS-stimulated PBM and AM with Dex (10(-6) to 10(-8) M) resulted in 75% decline in IL-8 mRNA and extracellular protein from either cell population.	Dexamethasone	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
1728298-9	1992	Pretreatment of PBM with PGE2 or Dex 1 or 2 h before LPS stimulation caused a significant suppression of steady-state IL-8 mRNA levels; however, administration of either of these modulators 1 or 2 h after LPS stimulation failed to have an inhibitory effect.	pbm	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
1728298-9	1992	Pretreatment of PBM with PGE2 or Dex 1 or 2 h before LPS stimulation caused a significant suppression of steady-state IL-8 mRNA levels; however, administration of either of these modulators 1 or 2 h after LPS stimulation failed to have an inhibitory effect.	Dinoprostone	25-29	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
1728298-9	1992	Pretreatment of PBM with PGE2 or Dex 1 or 2 h before LPS stimulation caused a significant suppression of steady-state IL-8 mRNA levels; however, administration of either of these modulators 1 or 2 h after LPS stimulation failed to have an inhibitory effect.	Dexamethasone	33-36	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
1511463-9	1992	Supernatants from OK432-stimulated mononuclear cells, as determined by enzyme-linked immunosorbent assays and radioimmunoassays, contained high levels of interleukin-8 (IL-8; 1567 +/- 145 pg/ml) and tumor necrosis factor (TNF alpha; 2105 +/- 152 pg/ml), low levels of leukotriene B4 (800 +/- 45 pg/ml) and IL-1 beta (180 +/- 22 pg/ml), but interferon gamma was not detectable.	Leukotriene B4	268-282	C-X-C motif chemokine ligand 8	Homo sapiens	154-167
1370208-4	1992	Dexamethasone (1 mumol/L) concordantly repressed expression of GM-CSF, NAP-1/IL-8 and IL-6.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	71-76
1370208-4	1992	Dexamethasone (1 mumol/L) concordantly repressed expression of GM-CSF, NAP-1/IL-8 and IL-6.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
1370208-9	1992	Further experiments showed that dexamethasone downregulates expression of GM-CSF, NAP-1/IL-8, and IL-6 mainly by decreasing the mRNA stability of these cytokines, and that the dexamethasone-mediated repression of cytokine expression depends on ongoing protein and RNA syntheses.	Dexamethasone	32-45	C-X-C motif chemokine ligand 8	Homo sapiens	82-87
1370208-9	1992	Further experiments showed that dexamethasone downregulates expression of GM-CSF, NAP-1/IL-8, and IL-6 mainly by decreasing the mRNA stability of these cytokines, and that the dexamethasone-mediated repression of cytokine expression depends on ongoing protein and RNA syntheses.	Dexamethasone	32-45	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
1370208-9	1992	Further experiments showed that dexamethasone downregulates expression of GM-CSF, NAP-1/IL-8, and IL-6 mainly by decreasing the mRNA stability of these cytokines, and that the dexamethasone-mediated repression of cytokine expression depends on ongoing protein and RNA syntheses.	Dexamethasone	176-189	C-X-C motif chemokine ligand 8	Homo sapiens	82-87
1370208-9	1992	Further experiments showed that dexamethasone downregulates expression of GM-CSF, NAP-1/IL-8, and IL-6 mainly by decreasing the mRNA stability of these cytokines, and that the dexamethasone-mediated repression of cytokine expression depends on ongoing protein and RNA syntheses.	Dexamethasone	176-189	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
1425895-1	1992	Sodium fluoride (NaF) is used in the treatment of axial osteoporosis and so is mostly given to old patients.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
1423439-4	1992	Under the pH cycling conditions of the present study, the NaF dentifrice and mouthwash were observed to have a considerably higher uptake of fluoride in the lesion than the MFP dentifrice.	Fluorides	141-149	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
1309871-3	1992	Moreover, postreceptor stimulation of superoxide production by NaF (a G protein activator), but not by phorbol myristate acetate, was significantly inhibited by SC-41930, indicating that SC-41930 may act via attenuation of a G protein-mediated signal transduction.	Superoxides	38-48	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
1537591-3	1992	Co-incubation of neutrophils with neomycin and the direct G-protein activator sodium fluoride (NaF) resulted in an enhanced leukotriene formation at 0.5 mM neomycin and an inhibition at a concentration of 10 mM.	Neomycin	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
1537591-3	1992	Co-incubation of neutrophils with neomycin and the direct G-protein activator sodium fluoride (NaF) resulted in an enhanced leukotriene formation at 0.5 mM neomycin and an inhibition at a concentration of 10 mM.	Sodium Fluoride	78-93	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
1537591-3	1992	Co-incubation of neutrophils with neomycin and the direct G-protein activator sodium fluoride (NaF) resulted in an enhanced leukotriene formation at 0.5 mM neomycin and an inhibition at a concentration of 10 mM.	Leukotrienes	124-135	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
1537591-3	1992	Co-incubation of neutrophils with neomycin and the direct G-protein activator sodium fluoride (NaF) resulted in an enhanced leukotriene formation at 0.5 mM neomycin and an inhibition at a concentration of 10 mM.	Neomycin	156-164	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
1537591-5	1992	However, pretreatment of neutrophils with 10 mM neomycin followed by the addition of NaF or FMLP resulted in an enhanced generation of leukotrienes.	Leukotrienes	135-147	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
1740648-0	1992	Heterogeneity in the mobilization of cytoplasmic calcium by human polymorphonuclear leukocytes in response to fMLP, C5a and IL-8/NAP-1.	Calcium	49-56	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
1740648-0	1992	Heterogeneity in the mobilization of cytoplasmic calcium by human polymorphonuclear leukocytes in response to fMLP, C5a and IL-8/NAP-1.	Calcium	49-56	C-X-C motif chemokine ligand 8	Homo sapiens	129-134
1726709-1	1991	Interleukin-8 (IL-8) stimulated an increase in cytoplasmic-free Ca2+ ([Ca2+]i) and intracellular pH (pHi) in parallel at low concentrations (0.5 to 5 ng/mL), and stimulated O2- release and membrane depolarization in parallel at high concentrations (50 to 5,000 ng/mL).	Oxygen	173-175	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
1720306-0	1991	Induction of members of the IL-8/NAP-1 gene family in human T lymphocytes is suppressed by cyclosporin A.	Cyclosporine	91-104	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
1720306-0	1991	Induction of members of the IL-8/NAP-1 gene family in human T lymphocytes is suppressed by cyclosporin A.	Cyclosporine	91-104	C-X-C motif chemokine ligand 8	Homo sapiens	33-38
1726709-4	1991	In addition, IL-8 was found to be a potent priming agent and to enhance O2- release stimulated by FMLP.	Oxygen	72-74	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
1439483-0	1992	Interleukin-8 in inflammatory rheumatic diseases: synovial fluid levels, relation to rheumatoid factors, production by mononuclear cells, and effects of gold sodium thiomalate and methotrexate.	Gold Sodium Thiomalate	153-175	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
1439483-5	1992	Gold sodium thiomalate (GST) and methotrexate (MTX) inhibited the spontaneous and stimulated IL-8 production by PBMC by 55-86% at 50 and 10 micrograms/ml, respectively.	Gold Sodium Thiomalate	0-22	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
1439483-5	1992	Gold sodium thiomalate (GST) and methotrexate (MTX) inhibited the spontaneous and stimulated IL-8 production by PBMC by 55-86% at 50 and 10 micrograms/ml, respectively.	Methotrexate	33-45	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
1439483-5	1992	Gold sodium thiomalate (GST) and methotrexate (MTX) inhibited the spontaneous and stimulated IL-8 production by PBMC by 55-86% at 50 and 10 micrograms/ml, respectively.	Methotrexate	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
1439483-6	1992	Two main conclusions were drawn: (1) rheumatoid factors appeared to be a major cause of enhanced IL-8 production in seropositive RA, and (2) inhibition of IL-8-mediated neutrophil migration and activation could be part of the mechanism of action of GST and MTX.	Methotrexate	257-260	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
1492198-3	1992	The mentioned fact supported authors to study the impact of short-term 24 hrs sodium fluoride (NaF) action in concentration range of 0-500 mg.1(-1) drinking water in the frame of so-called minimal testing set (analysis of chromosomal aberrations in human peripheral lymphocytes, Ames test).	Sodium Fluoride	78-93	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
1492198-3	1992	The mentioned fact supported authors to study the impact of short-term 24 hrs sodium fluoride (NaF) action in concentration range of 0-500 mg.1(-1) drinking water in the frame of so-called minimal testing set (analysis of chromosomal aberrations in human peripheral lymphocytes, Ames test).	Drinking Water	148-162	C-X-C motif chemokine ligand 8	Homo sapiens	95-98
1492198-7	1992	Yet one order higher NaF concentration than its application norm 1 mg.l-1 (i.e. 11 mg.l-1) has induced the occurrence of 3.8% ABB after single addition for 24 hrs to the "healthy" blood cultivated in vitro at short-term.	ABB	126-129	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
1492198-10	1992	Thus the two orders higher NaF concentration (110.0 mg.l-1) resulted in a strong increase of cells with chromosomal aberrations for all of indicators observed; e.g. 27.5% ABB.	ABB	171-174	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
1958385-7	1991	The adherence of Am resulted in the induction of de novo IL-8 mRNA synthesis, as this mRNA accumulation was completely abrogated by actinomycin D.	Dactinomycin	132-145	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
1774379-6	1991	Two recently isolated fluoride-resistant S. mutans strains produced more lactate and demineralized enamel more than did two recently isolated S. mutans strains from normal human subjects, both in the presence of 0 and 0.05 mmol/L NaF.	Fluorides	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	230-233
1726709-1	1991	Interleukin-8 (IL-8) stimulated an increase in cytoplasmic-free Ca2+ ([Ca2+]i) and intracellular pH (pHi) in parallel at low concentrations (0.5 to 5 ng/mL), and stimulated O2- release and membrane depolarization in parallel at high concentrations (50 to 5,000 ng/mL).	Oxygen	173-175	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
1726709-2	1991	IL-8-induced O2- release was potentiated by tumor necrosis factor (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and granulocyte-CSF (G-CSF) in a dose-dependent manner, whereas it was inhibited by cyclic AMP agonists.	Cyclic AMP	216-226	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
1663497-2	1991	Diazepam also inhibited the superoxide production induced by FMLP, NaF, and A23187, but not that induced by PMA whose stimulant action was insensitive even to 10(-4) M diazepam.	Diazepam	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
1665748-11	1991	Addition of 10 mM NaF at the plateau phase of [3H]-IP1 accumulation induced by 1 mM histamine resulted in a further increase in the level of [3H]-IP1.	Tritium	47-49	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
1665748-11	1991	Addition of 10 mM NaF at the plateau phase of [3H]-IP1 accumulation induced by 1 mM histamine resulted in a further increase in the level of [3H]-IP1.	Isopenicillin N	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
1665748-11	1991	Addition of 10 mM NaF at the plateau phase of [3H]-IP1 accumulation induced by 1 mM histamine resulted in a further increase in the level of [3H]-IP1.	Histamine	84-93	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
1665748-11	1991	Addition of 10 mM NaF at the plateau phase of [3H]-IP1 accumulation induced by 1 mM histamine resulted in a further increase in the level of [3H]-IP1.	Tritium	142-144	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
1665748-11	1991	Addition of 10 mM NaF at the plateau phase of [3H]-IP1 accumulation induced by 1 mM histamine resulted in a further increase in the level of [3H]-IP1.	Isopenicillin N	146-149	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
1665748-12	1991	The level of [3H]-IP1 in the presence of histamine + NaF was 1.4 +/- 0.2 fold of that of the sum of the responses to histamine and NaF acting alone (basal levels subtracted).	[3h]-ip1	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
1665748-12	1991	The level of [3H]-IP1 in the presence of histamine + NaF was 1.4 +/- 0.2 fold of that of the sum of the responses to histamine and NaF acting alone (basal levels subtracted).	[3h]-ip1	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
1752461-4	1991	NaF stimulated adenylate cyclase activity was inhibited by 50% at 2.5 mmol/l EGTA.	Egtazic Acid	77-81	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
1663497-2	1991	Diazepam also inhibited the superoxide production induced by FMLP, NaF, and A23187, but not that induced by PMA whose stimulant action was insensitive even to 10(-4) M diazepam.	Superoxides	28-38	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
1960255-4	1991	Results showed that lesions treated with the triclosan-fluoride product were remineralized 18.0 +/- 23.4% compared with 19.0 +/- 32.3% from a 1100-ppm F (NaF) positive control.	triclosan-fluoride	45-63	C-X-C motif chemokine ligand 8	Homo sapiens	154-157
1723766-6	1991	Treatment with NaF/AlCl3, which uncouples G protein-mediated responses, caused significant attenuation of the relaxation responses to ADO, NECA, and CAD.	Aluminum Chloride	19-24	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
1664043-1	1991	The interaction of the vitamin D receptor with a vitamin D-responsive element (VDRE) derived from the human osteocalcin promoter in vitro has been shown to require a nuclear accessory factor (NAF) derived from monkey kidney cells.	Vitamin D	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	192-195
1664043-7	1991	NAF is a protein of 55 kDa, as assessed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and cross-linking experiments suggest that the VDR and NAF together form a heterodimer on a single VDRE with a mol wt of 103 kDa.	Sodium Dodecyl Sulfate	43-65	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
1664043-7	1991	NAF is a protein of 55 kDa, as assessed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and cross-linking experiments suggest that the VDR and NAF together form a heterodimer on a single VDRE with a mol wt of 103 kDa.	polyacrylamide	66-80	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
1800124-0	1991	Stimulation of miniature end-plate potential frequency by fluoride may involve activation of protein kinase C. NaF caused a dose-dependent rise in miniature end-plate potential (MEPP) frequency at the frog neuromuscular junction.	Fluorides	58-66	C-X-C motif chemokine ligand 8	Homo sapiens	111-114
1660854-2	1991	Similar data were observed for the direct G-protein activator sodium fluoride (NaF).	Sodium Fluoride	62-77	C-X-C motif chemokine ligand 8	Homo sapiens	79-82
1681733-5	1991	Using the same antibody, IL-8 was immunoprecipitated from the supernatants of TNF-stimulated 35S-labelled keratinocytes, and a single 7-kd band product detected by SDS-PAGE.	Sulfur-35	93-96	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
1681733-5	1991	Using the same antibody, IL-8 was immunoprecipitated from the supernatants of TNF-stimulated 35S-labelled keratinocytes, and a single 7-kd band product detected by SDS-PAGE.	Sodium Dodecyl Sulfate	164-167	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
1681733-6	1991	In keeping with these biological activities and protein data, Northern blot analysis of total cellular RNA extracted from keratinocyte monolayers hybridized with a 32P-labelled 1-kb cDNA to IL-8 mRNA, revealed induction of the IL-8 gene in the presence of TNF-alpha and IL-1 beta, but not IFN-gamma.	Phosphorus-32	164-167	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
1681733-6	1991	In keeping with these biological activities and protein data, Northern blot analysis of total cellular RNA extracted from keratinocyte monolayers hybridized with a 32P-labelled 1-kb cDNA to IL-8 mRNA, revealed induction of the IL-8 gene in the presence of TNF-alpha and IL-1 beta, but not IFN-gamma.	Phosphorus-32	164-167	C-X-C motif chemokine ligand 8	Homo sapiens	227-231
1918013-1	1991	In order to identify residues required for the binding of interleukin-8 (IL-8) to its receptor, mutants were constructed in which clusters of charged amino acids were systematically replaced with alanine along the entire IL-8 sequence.	Alanine	196-203	C-X-C motif chemokine ligand 8	Homo sapiens	58-71
1918013-1	1991	In order to identify residues required for the binding of interleukin-8 (IL-8) to its receptor, mutants were constructed in which clusters of charged amino acids were systematically replaced with alanine along the entire IL-8 sequence.	Alanine	196-203	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
1918013-2	1991	The mutants were tested for their ability to induce a receptor-mediated rise in cytosolic free Ca2+, a property of wild-type IL-8 which can readily be detected by flow cytometry using neutrophils loaded with the calcium probe Indo-1.	Calcium	212-219	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
1918955-6	1991	Moreover, RA synovial fluid chemotactic activity for PMN in these fluids was inhibited 40 +/- 5% upon incubation with neutralizing polyclonal antibody to IL-8.	Radium	10-12	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
1918955-12	1991	These results suggest that macrophage-derived IL-8 may play an important role in the recruitment of PMN in synovial inflammation associated with RA.	Radium	145-147	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
1930284-7	1991	Analysis of inhibition kinetics further showed that (a) the reversible inhibition of both ComEst and MonEst by sodium fluoride (NaF) was noncompetitive (with Ki values of 1.28 and 0.01 mM, respectively, indicating a marked difference in sensitivity); (b) the inhibition of MonEst by PMSF was of "mixed" noncompetitive-competitive type; and (c) that DEPC exerted noncompetitive inhibition with similar Ki values (0.05 mM) for both esterase species.	Sodium Fluoride	111-126	C-X-C motif chemokine ligand 8	Homo sapiens	128-131
1930284-7	1991	Analysis of inhibition kinetics further showed that (a) the reversible inhibition of both ComEst and MonEst by sodium fluoride (NaF) was noncompetitive (with Ki values of 1.28 and 0.01 mM, respectively, indicating a marked difference in sensitivity); (b) the inhibition of MonEst by PMSF was of "mixed" noncompetitive-competitive type; and (c) that DEPC exerted noncompetitive inhibition with similar Ki values (0.05 mM) for both esterase species.	Phenylmethylsulfonyl Fluoride	283-287	C-X-C motif chemokine ligand 8	Homo sapiens	128-131
1653806-13	1991	Cyclosporines partially inhibited O2- formations induced by NaF and gamma-hexachlorocyclohexane.	Cyclosporins	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
1911878-6	1991	On the other hand, with agonists that can by-pass (at least partially) the receptor-transductor-effector sequence, such as high-dose thrombin, PMA, NaF, only the exposure of fibrinogen receptors is blocked by ajoene.	ajoene	209-215	C-X-C motif chemokine ligand 8	Homo sapiens	148-151
1653806-13	1991	Cyclosporines partially inhibited O2- formations induced by NaF and gamma-hexachlorocyclohexane.	Superoxides	34-36	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
1716285-0	1991	IL-8 inhibits histamine release from human basophils induced by histamine-releasing factors, connective tissue activating peptide III, and IL-3.	Histamine	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
1891716-2	1991	Neutrophils express receptors for IL-8 that are coupled to guanine nucleotide-binding proteins (G proteins); binding of IL-8 to its receptor induces the mobilization of intracellular calcium stores.	Calcium	183-190	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
1716285-2	1991	We now report the effect of IL-8 upon HRF-, connective tissue activating peptide III (CTAP III)-, and IL-3-induced histamine release from human basophils.	Histamine	115-124	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
1716285-4	1991	When basophils were preincubated with IL-8 (10(-7) to 10(-11) M) for 5 min, followed by a 40-min incubation with HRF, histamine release was significantly inhibited in 20 of 25 donors.	Histamine	118-127	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
1716285-5	1991	Inhibition was observed at as little as 10(-11) M IL-8, with maximal inhibition being attained at 10(-9) M. HRF-containing supernatants contain a mixture of different histamine-releasing moieties.	Histamine	167-176	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
1716285-7	1991	Histamine release produced by two different HRF-containing chromatographic fractions (HRFvoid and HRFpeak 2) and purified CTAP-III (5 micrograms/ml) was inhibited by IL-8 in 10 of 12 donors, three of three donors, and seven of 10 donors, respectively.	Histamine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
1716285-8	1991	IL-3 (5000 U/ml)-dependent histamine release was inhibited by IL-8 in all subjects tested.	Histamine	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
1840701-6	1991	Mammalian cells transfected with the IL-8 receptor cDNA clone bind IL-8 with high affinity and respond specifically to IL-8 by transiently mobilizing calcium.	Calcium	150-157	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
1840701-6	1991	Mammalian cells transfected with the IL-8 receptor cDNA clone bind IL-8 with high affinity and respond specifically to IL-8 by transiently mobilizing calcium.	Calcium	150-157	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
1840701-6	1991	Mammalian cells transfected with the IL-8 receptor cDNA clone bind IL-8 with high affinity and respond specifically to IL-8 by transiently mobilizing calcium.	Calcium	150-157	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
1922513-2	1991	When blood was preserved in microtest tubes coated with sodium fluoride (NaF) and measured after 1 hour at room temperature, the glucose level decreased by 7 to 36%.	Sodium Fluoride	56-71	C-X-C motif chemokine ligand 8	Homo sapiens	73-76
1922513-2	1991	When blood was preserved in microtest tubes coated with sodium fluoride (NaF) and measured after 1 hour at room temperature, the glucose level decreased by 7 to 36%.	Glucose	129-136	C-X-C motif chemokine ligand 8	Homo sapiens	73-76
1891716-2	1991	Neutrophils express receptors for IL-8 that are coupled to guanine nucleotide-binding proteins (G proteins); binding of IL-8 to its receptor induces the mobilization of intracellular calcium stores.	Calcium	183-190	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
1856599-6	1991	Antigenic and bioactive IL-8 were significantly apparent by 4-8 h, respectively, and increased significantly to maximal levels by 24 h. Furthermore, adherent PBMC IL-8 gene expression was suppressed by either concomitant treatment with actinomycin-D or cycloheximide, yet specific neutralizing antibodies directed against either IL-1 beta or tumor necrosis factor (TNF)-alpha failed to alter adherence-induced steady-state IL-8 mRNA levels.	Dactinomycin	236-249	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
1939046-0	1991	Effect of sodium lauryl sulfate on the uptake of fluoride from NaF and MFP by etched enamel in vitro.	Sodium Dodecyl Sulfate	10-31	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
1939046-0	1991	Effect of sodium lauryl sulfate on the uptake of fluoride from NaF and MFP by etched enamel in vitro.	Fluorides	49-57	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
1856599-6	1991	Antigenic and bioactive IL-8 were significantly apparent by 4-8 h, respectively, and increased significantly to maximal levels by 24 h. Furthermore, adherent PBMC IL-8 gene expression was suppressed by either concomitant treatment with actinomycin-D or cycloheximide, yet specific neutralizing antibodies directed against either IL-1 beta or tumor necrosis factor (TNF)-alpha failed to alter adherence-induced steady-state IL-8 mRNA levels.	Dactinomycin	236-249	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
1856599-6	1991	Antigenic and bioactive IL-8 were significantly apparent by 4-8 h, respectively, and increased significantly to maximal levels by 24 h. Furthermore, adherent PBMC IL-8 gene expression was suppressed by either concomitant treatment with actinomycin-D or cycloheximide, yet specific neutralizing antibodies directed against either IL-1 beta or tumor necrosis factor (TNF)-alpha failed to alter adherence-induced steady-state IL-8 mRNA levels.	Dactinomycin	236-249	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
1856599-6	1991	Antigenic and bioactive IL-8 were significantly apparent by 4-8 h, respectively, and increased significantly to maximal levels by 24 h. Furthermore, adherent PBMC IL-8 gene expression was suppressed by either concomitant treatment with actinomycin-D or cycloheximide, yet specific neutralizing antibodies directed against either IL-1 beta or tumor necrosis factor (TNF)-alpha failed to alter adherence-induced steady-state IL-8 mRNA levels.	Cycloheximide	253-266	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
1856599-6	1991	Antigenic and bioactive IL-8 were significantly apparent by 4-8 h, respectively, and increased significantly to maximal levels by 24 h. Furthermore, adherent PBMC IL-8 gene expression was suppressed by either concomitant treatment with actinomycin-D or cycloheximide, yet specific neutralizing antibodies directed against either IL-1 beta or tumor necrosis factor (TNF)-alpha failed to alter adherence-induced steady-state IL-8 mRNA levels.	Cycloheximide	253-266	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
1856599-6	1991	Antigenic and bioactive IL-8 were significantly apparent by 4-8 h, respectively, and increased significantly to maximal levels by 24 h. Furthermore, adherent PBMC IL-8 gene expression was suppressed by either concomitant treatment with actinomycin-D or cycloheximide, yet specific neutralizing antibodies directed against either IL-1 beta or tumor necrosis factor (TNF)-alpha failed to alter adherence-induced steady-state IL-8 mRNA levels.	Cycloheximide	253-266	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
1912761-2	1991	During 12 h following a dose of SR-NaF, serum fluoride levels could be largely kept within the therapeutic window (believed to be 95-190 ng/ml or 5-10 mumol/l).	Fluorides	46-54	C-X-C motif chemokine ligand 8	Homo sapiens	35-38
1715699-0	1991	Interleukin 8-inhibitor and inducer of histamine and leukotriene release in human basophils.	Histamine	39-48	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
1715699-0	1991	Interleukin 8-inhibitor and inducer of histamine and leukotriene release in human basophils.	Leukotrienes	53-64	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
1715699-1	1991	We have shown previously that interleukin 8 (IL-8) induces histamine and leukotriene release in human basophils exposed to interleukin 3 (IL-3).	Histamine	59-68	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
1715699-1	1991	We have shown previously that interleukin 8 (IL-8) induces histamine and leukotriene release in human basophils exposed to interleukin 3 (IL-3).	Histamine	59-68	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
1715699-1	1991	We have shown previously that interleukin 8 (IL-8) induces histamine and leukotriene release in human basophils exposed to interleukin 3 (IL-3).	Leukotrienes	73-84	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
1715699-1	1991	We have shown previously that interleukin 8 (IL-8) induces histamine and leukotriene release in human basophils exposed to interleukin 3 (IL-3).	Leukotrienes	73-84	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
1651933-12	1991	The tyrosine phosphatase was inhibited by ammonium molybdate (IC50 of 2 microM), sodium vanadate (IC50 of 150 microM) and the divalent cations Mg2+, Mn2+, and Ca2+ at millimolar concentrations, but not by 100 microM ZnCl or 10 mM NaF.	ammonium molybdate	42-60	C-X-C motif chemokine ligand 8	Homo sapiens	230-233
1651933-12	1991	The tyrosine phosphatase was inhibited by ammonium molybdate (IC50 of 2 microM), sodium vanadate (IC50 of 150 microM) and the divalent cations Mg2+, Mn2+, and Ca2+ at millimolar concentrations, but not by 100 microM ZnCl or 10 mM NaF.	Vanadates	81-96	C-X-C motif chemokine ligand 8	Homo sapiens	230-233
1651933-12	1991	The tyrosine phosphatase was inhibited by ammonium molybdate (IC50 of 2 microM), sodium vanadate (IC50 of 150 microM) and the divalent cations Mg2+, Mn2+, and Ca2+ at millimolar concentrations, but not by 100 microM ZnCl or 10 mM NaF.	magnesium ion	143-147	C-X-C motif chemokine ligand 8	Homo sapiens	230-233
1651933-12	1991	The tyrosine phosphatase was inhibited by ammonium molybdate (IC50 of 2 microM), sodium vanadate (IC50 of 150 microM) and the divalent cations Mg2+, Mn2+, and Ca2+ at millimolar concentrations, but not by 100 microM ZnCl or 10 mM NaF.	Manganese(2+)	149-153	C-X-C motif chemokine ligand 8	Homo sapiens	230-233
1654060-2	1991	We report that sodium fluoride (NaF), a potent activator of cellular guanine nucleotide-binding proteins, affected time- and concentration-dependent generation of prostacyclin (PGI2) by cultured human umbilical vein endothelial cells without evidence of cellular toxicity detected by 51Cr or lactate dehydrogenase release.	Sodium Fluoride	15-30	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
1654060-2	1991	We report that sodium fluoride (NaF), a potent activator of cellular guanine nucleotide-binding proteins, affected time- and concentration-dependent generation of prostacyclin (PGI2) by cultured human umbilical vein endothelial cells without evidence of cellular toxicity detected by 51Cr or lactate dehydrogenase release.	Guanine Nucleotides	69-87	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
1654060-2	1991	We report that sodium fluoride (NaF), a potent activator of cellular guanine nucleotide-binding proteins, affected time- and concentration-dependent generation of prostacyclin (PGI2) by cultured human umbilical vein endothelial cells without evidence of cellular toxicity detected by 51Cr or lactate dehydrogenase release.	Epoprostenol	163-175	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
1654060-2	1991	We report that sodium fluoride (NaF), a potent activator of cellular guanine nucleotide-binding proteins, affected time- and concentration-dependent generation of prostacyclin (PGI2) by cultured human umbilical vein endothelial cells without evidence of cellular toxicity detected by 51Cr or lactate dehydrogenase release.	Epoprostenol	177-181	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
1654060-3	1991	PGI2 synthesis by NaF-stimulated endothelial cells was associated with increases in arachidonate release, phosphoinositide hydrolysis, generation of inositol phosphates, and accumulation of diacylglycerol.	Epoprostenol	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
1654060-3	1991	PGI2 synthesis by NaF-stimulated endothelial cells was associated with increases in arachidonate release, phosphoinositide hydrolysis, generation of inositol phosphates, and accumulation of diacylglycerol.	Arachidonic Acid	84-96	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
1654060-3	1991	PGI2 synthesis by NaF-stimulated endothelial cells was associated with increases in arachidonate release, phosphoinositide hydrolysis, generation of inositol phosphates, and accumulation of diacylglycerol.	Phosphatidylinositols	106-122	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
1654060-3	1991	PGI2 synthesis by NaF-stimulated endothelial cells was associated with increases in arachidonate release, phosphoinositide hydrolysis, generation of inositol phosphates, and accumulation of diacylglycerol.	Inositol Phosphates	149-168	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
1654060-3	1991	PGI2 synthesis by NaF-stimulated endothelial cells was associated with increases in arachidonate release, phosphoinositide hydrolysis, generation of inositol phosphates, and accumulation of diacylglycerol.	Diglycerides	190-204	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
1912761-4	1991	Compared to SR-NaF, IR-NaF caused a significantly higher peak fluoride concentration in serum (322 vs. 158 ng/ml), and greater area under the curve (2269 vs. 1321 ng.h/ml) and urinary fluoride (6.72 vs. 3.80 mg/12 h).	Fluorides	62-70	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
1912761-4	1991	Compared to SR-NaF, IR-NaF caused a significantly higher peak fluoride concentration in serum (322 vs. 158 ng/ml), and greater area under the curve (2269 vs. 1321 ng.h/ml) and urinary fluoride (6.72 vs. 3.80 mg/12 h).	Fluorides	184-192	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
1912761-5	1991	Thus, fluoride absorption from IR-NaF was twice as high as that from SR-NaF.	Fluorides	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
1912761-5	1991	Thus, fluoride absorption from IR-NaF was twice as high as that from SR-NaF.	Strontium	69-71	C-X-C motif chemokine ligand 8	Homo sapiens	72-75
1650387-10	1991	Intravenous administration of [Ser-IL-8]72 yielded similar results.	Serine	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
1650387-13	1991	Intradermal injections of [Ala-IL-8]77 or [Ser-IL-8]72 induced dose-dependent PMN accumulation, which also was significantly reduced by i.v.	Alanine	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
1650387-13	1991	Intradermal injections of [Ala-IL-8]77 or [Ser-IL-8]72 induced dose-dependent PMN accumulation, which also was significantly reduced by i.v.	Serine	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
1856209-2	1991	The production of IL-8 is usually not constitutive and can be induced rapidly and abundantly in different cell types by a variety of stimuli such as lipopolysaccharide, interleukin-1, tumor necrosis factor-alpha as well as a tumor promotor phorbol myristate acetate.	Tetradecanoylphorbol Acetate	240-265	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
2059236-3	1991	Because the release of monocyte-derived neutrophil chemotactic activity was markedly diminished by pretreatment of the monocytes with cycloheximide, and was completely removed from conditioned media by adsorption to heparin-agarose, we addressed the possibility that monocyte-derived neutrophil chemotactic factor/interleukin-8 (IL-8), a heparin-binding neutrophil-activating polypeptide, might modulate these activities.	Heparin	216-223	C-X-C motif chemokine ligand 8	Homo sapiens	329-333
2059236-5	1991	In addition, an IL-8-specific antibody markedly inhibited the neutrophil-activating capacity of the conditioned media from monocytes activated by urate crystals, as well as by inflammatory silica crystals.	Uric Acid	146-151	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
2059236-5	1991	In addition, an IL-8-specific antibody markedly inhibited the neutrophil-activating capacity of the conditioned media from monocytes activated by urate crystals, as well as by inflammatory silica crystals.	Silicon Dioxide	189-195	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
1882646-0	1991	Release of fluoride and metal ions from root surfaces after topical application of TiF4, SnF2, and NaF in vitro.	Fluorides	11-19	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
1937585-3	1991	The buffy-coat cellular expression of neutrophil chemotactic/activating factor/interleukin 8 (IL-8) and monocyte chemotactic/activating protein (MCP-1) mRNA were time and dose-dependent in response to either lipopolysaccharide or zymosan stimulation.	Zymosan	230-237	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
1921160-2	1991	Dexamethasone treatment of mesangial cells induced partial inhibition of the release of extracellular IL-8, while cell-associated IL-8 and IL-8 mRNA were not significantly altered.	Dexamethasone	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
2037605-10	1991	Stimulation of neutrophils with NAP-1/IL-8 resulted in desensitization toward a subsequent challenge with NAP-2 or gro/MGSA as shown by the rise in cytosolic free calcium.	Calcium	163-170	C-X-C motif chemokine ligand 8	Homo sapiens	32-37
2037605-10	1991	Stimulation of neutrophils with NAP-1/IL-8 resulted in desensitization toward a subsequent challenge with NAP-2 or gro/MGSA as shown by the rise in cytosolic free calcium.	Calcium	163-170	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
1873480-5	1991	Therefore, we addressed the question of whether the clinical improvement of psoriatic patients during CsA therapy may be due to an inhibition of NAP-1/IL-8 production and secretion from monocytes.	Cyclosporine	102-105	C-X-C motif chemokine ligand 8	Homo sapiens	145-150
1873480-5	1991	Therefore, we addressed the question of whether the clinical improvement of psoriatic patients during CsA therapy may be due to an inhibition of NAP-1/IL-8 production and secretion from monocytes.	Cyclosporine	102-105	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
1652553-6	1991	Neither chemiluminescence by PMN nor platelet aggregation showed a similar pattern compared to the mediator release: PMN preincubated with FMLP followed by NaF resulted in a second chemiluminescence response; the aggregation of platelets which were preincubated with thrombin was partially inhibited by the addition of NaF.	platensimycin	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	319-322
1882646-0	1991	Release of fluoride and metal ions from root surfaces after topical application of TiF4, SnF2, and NaF in vitro.	Metals	24-29	C-X-C motif chemokine ligand 8	Homo sapiens	99-102
1827816-3	1991	However T cells stimulated with a combination of PMA and ionomycin or PMA and PHA expressed IL-8 mRNA in a PMA dose-dependent manner and maximally after 3 to 6 h of culture.	Ionomycin	57-66	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
1827816-6	1991	In addition, immunoprecipitation analysis of PMA/ionomycin-treated T cell lysates detected only minor levels of cellular IL-8 Ag thereby suggesting that in T cells, the production of IL-8 was inhibited at the posttranscriptional level.	Tetradecanoylphorbol Acetate	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
1827816-6	1991	In addition, immunoprecipitation analysis of PMA/ionomycin-treated T cell lysates detected only minor levels of cellular IL-8 Ag thereby suggesting that in T cells, the production of IL-8 was inhibited at the posttranscriptional level.	Ionomycin	49-58	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
1827816-6	1991	In addition, immunoprecipitation analysis of PMA/ionomycin-treated T cell lysates detected only minor levels of cellular IL-8 Ag thereby suggesting that in T cells, the production of IL-8 was inhibited at the posttranscriptional level.	Ionomycin	49-58	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
1851210-3	1991	Ethanol exposure reduced guanosine 5"-O-(3-thiotriphosphate) [GTP(S)]- and, to a lesser extent, NaF/AlCl3-stimulated phosphoinositide hydrolysis, whereas it had no effect on the enzymatic activity of a phosphatidylinositol 4,5-bisphosphate-specific phospholipase C. [3H]Bradykinin binding in the absence of GTP(S) was not influenced by ethanol exposure.	Ethanol	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	96-99
1851210-3	1991	Ethanol exposure reduced guanosine 5"-O-(3-thiotriphosphate) [GTP(S)]- and, to a lesser extent, NaF/AlCl3-stimulated phosphoinositide hydrolysis, whereas it had no effect on the enzymatic activity of a phosphatidylinositol 4,5-bisphosphate-specific phospholipase C. [3H]Bradykinin binding in the absence of GTP(S) was not influenced by ethanol exposure.	Aluminum Chloride	100-105	C-X-C motif chemokine ligand 8	Homo sapiens	96-99
1851210-3	1991	Ethanol exposure reduced guanosine 5"-O-(3-thiotriphosphate) [GTP(S)]- and, to a lesser extent, NaF/AlCl3-stimulated phosphoinositide hydrolysis, whereas it had no effect on the enzymatic activity of a phosphatidylinositol 4,5-bisphosphate-specific phospholipase C. [3H]Bradykinin binding in the absence of GTP(S) was not influenced by ethanol exposure.	Phosphatidylinositols	117-133	C-X-C motif chemokine ligand 8	Homo sapiens	96-99
1945816-8	1991	The slabs treated with 2% NaF and then 1 mol/L KOH would contain the KOH-insoluble fluoride.	potassium hydroxide	69-72	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
1945816-8	1991	The slabs treated with 2% NaF and then 1 mol/L KOH would contain the KOH-insoluble fluoride.	Fluorides	83-91	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
1945816-9	1991	Those treated with only 2% NaF would, in addition, contain KOH-soluble fluoride.	potassium hydroxide	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
1945816-9	1991	Those treated with only 2% NaF would, in addition, contain KOH-soluble fluoride.	Fluorides	71-79	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
2007851-6	1991	IL-8 levels peaked at 2 h in subjects given either endotoxin alone or endotoxin/pentoxifylline, falling towards baseline by 5 h. Subjects given endotoxin/ibuprofen had a more sustained rise in IL-8 with peak levels 2.8- and 2.5-fold higher at 3 h compared to endotoxin alone (p = 0.048) or endotoxin/pentoxifylline (p = 0.023), respectively.	Pentoxifylline	300-314	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
1802021-2	1991	However, tetraplatin was a much more potent inhibitor than cisplatin, with its I50 values being 1/25, 1/45, and 1/130 that of cisplatin in the presence of DA/Gpp(NH)p, NaF/AlCl3, and forskolin/Gpp(NH)p respectively.	ormaplatin	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	168-171
1802021-2	1991	However, tetraplatin was a much more potent inhibitor than cisplatin, with its I50 values being 1/25, 1/45, and 1/130 that of cisplatin in the presence of DA/Gpp(NH)p, NaF/AlCl3, and forskolin/Gpp(NH)p respectively.	Cisplatin	59-68	C-X-C motif chemokine ligand 8	Homo sapiens	168-171
1802021-2	1991	However, tetraplatin was a much more potent inhibitor than cisplatin, with its I50 values being 1/25, 1/45, and 1/130 that of cisplatin in the presence of DA/Gpp(NH)p, NaF/AlCl3, and forskolin/Gpp(NH)p respectively.	Cisplatin	126-135	C-X-C motif chemokine ligand 8	Homo sapiens	168-171
1802021-2	1991	However, tetraplatin was a much more potent inhibitor than cisplatin, with its I50 values being 1/25, 1/45, and 1/130 that of cisplatin in the presence of DA/Gpp(NH)p, NaF/AlCl3, and forskolin/Gpp(NH)p respectively.	Phosphorus	14-15	C-X-C motif chemokine ligand 8	Homo sapiens	168-171
1680309-7	1991	Higher concentrations of BeSO4 precipitated tubulin, an effect which was not affected by Mg2+, partially prevented but not reversed by MAPs, and prevented or reversed by either NaF or nucleotides at adequate concentrations.	beryllium sulfate	25-30	C-X-C motif chemokine ligand 8	Homo sapiens	177-180
2007851-6	1991	IL-8 levels peaked at 2 h in subjects given either endotoxin alone or endotoxin/pentoxifylline, falling towards baseline by 5 h. Subjects given endotoxin/ibuprofen had a more sustained rise in IL-8 with peak levels 2.8- and 2.5-fold higher at 3 h compared to endotoxin alone (p = 0.048) or endotoxin/pentoxifylline (p = 0.023), respectively.	Pentoxifylline	80-94	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
2007851-6	1991	IL-8 levels peaked at 2 h in subjects given either endotoxin alone or endotoxin/pentoxifylline, falling towards baseline by 5 h. Subjects given endotoxin/ibuprofen had a more sustained rise in IL-8 with peak levels 2.8- and 2.5-fold higher at 3 h compared to endotoxin alone (p = 0.048) or endotoxin/pentoxifylline (p = 0.023), respectively.	Ibuprofen	154-163	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
2007851-6	1991	IL-8 levels peaked at 2 h in subjects given either endotoxin alone or endotoxin/pentoxifylline, falling towards baseline by 5 h. Subjects given endotoxin/ibuprofen had a more sustained rise in IL-8 with peak levels 2.8- and 2.5-fold higher at 3 h compared to endotoxin alone (p = 0.048) or endotoxin/pentoxifylline (p = 0.023), respectively.	Ibuprofen	154-163	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
1674864-3	1991	On the other hand, pretreatment of MKN-45 cells with retinoic acid (RA) significantly enhanced histamine-induced increase of cyclic AMP production, although the cyclic AMP response to either forskolin or NaF was not affected.	Tretinoin	68-70	C-X-C motif chemokine ligand 8	Homo sapiens	204-207
1674864-3	1991	On the other hand, pretreatment of MKN-45 cells with retinoic acid (RA) significantly enhanced histamine-induced increase of cyclic AMP production, although the cyclic AMP response to either forskolin or NaF was not affected.	Cyclic AMP	161-171	C-X-C motif chemokine ligand 8	Homo sapiens	204-207
2039486-0	1991	1,25(OH)2-D3 is a potent regulator of interleukin-1 induced interleukin-8 expression and production.	Calcitriol	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	60-73
2039486-3	1991	We studied the possible effect of an endogenous immune modulator 1,25(OH)2-cholecalciferol (1,25(OH)2-D3) on the IL-1-induced IL-8-production by several types of cells.	1,25(oh)2-cholecalciferol	65-90	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
2039486-3	1991	We studied the possible effect of an endogenous immune modulator 1,25(OH)2-cholecalciferol (1,25(OH)2-D3) on the IL-1-induced IL-8-production by several types of cells.	Calcitriol	92-104	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
2039486-4	1991	1,25(OH)2-D3 inhibited the IL-1-alpha induced IL-8 production and mRNA expression in keratinocytes, fibroblasts and PBMC, but not in endothelial cells.	Calcitriol	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Arginine	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Arginine	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Leucine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Leucine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Leucine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Leucine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Leucine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Arginine	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Arginine	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Arginine	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Arginine	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Arginine	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
1893074-4	1991	Southern blot analyses of plasmids containing IL-1 beta and IL-8 gave positive results with the 3" degenerate probe, 5"-acr-dTATTTATTN, clearly showing that the very short probe approach can be used in this type of analysis.	5"-acr-dtatttattn	117-134	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
2045129-0	1991	Interleukin-3, interleukin-8, FMLP and C5a enhance the release of leukotrienes from neutrophils of patients with atopic dermatitis.	Leukotrienes	66-78	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
1878329-2	1991	In the test group (n = 123, biweekly mouthrinsing with a 2% solution of mineralizing agent and 0.2% NaF solution) the percentage reduction in increment of both EFDS and DFS was high, whereas in the control group (n = 123, biweekly mouthrinsing with placebo and 0.2% NaF solutions) the incidence for symptoms of caries disease did not differ from that normally found in this age cohort.	aspartyl-phenylalanine	169-172	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
2007851-6	1991	IL-8 levels peaked at 2 h in subjects given either endotoxin alone or endotoxin/pentoxifylline, falling towards baseline by 5 h. Subjects given endotoxin/ibuprofen had a more sustained rise in IL-8 with peak levels 2.8- and 2.5-fold higher at 3 h compared to endotoxin alone (p = 0.048) or endotoxin/pentoxifylline (p = 0.023), respectively.	Pentoxifylline	300-314	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
2007851-8	1991	This trend reflected the increased release of IL-8 by the subjects receiving ibuprofen compared to pentoxifylline (1.9-fold higher; p = 0.024).	Ibuprofen	77-86	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
1850243-5	1991	However, propranolol induced a similar dose-dependent inhibition of O2- generation in neutrophils stimulated with either FMLP + cytochalasin B or with 20.0 mM NaF.	Propranolol	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	159-162
1873359-8	1991	An eventual decrease in the recovery of rTNF after collection of blood was prevented in the oxalate/NaF tubes.	Oxalates	92-99	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
2007144-5	1991	Synthetic and recombinant NAP-1/IL-8 were equally active on human neutrophil granulocytes as determined by measuring the induction of cytosolic free calcium, elastase release, and chemotaxis.	Calcium	149-156	C-X-C motif chemokine ligand 8	Homo sapiens	26-31
2007144-5	1991	Synthetic and recombinant NAP-1/IL-8 were equally active on human neutrophil granulocytes as determined by measuring the induction of cytosolic free calcium, elastase release, and chemotaxis.	Calcium	149-156	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
1850243-1	1991	Relatively high levels of propranolol (170 microM) markedly attenuated the generation of 1,2 diacylglycerol in neutrophils stimulated with either FMLP plus cytochalasin B or with 20.0 mM NaF.	Propranolol	26-37	C-X-C motif chemokine ligand 8	Homo sapiens	187-190
1850243-1	1991	Relatively high levels of propranolol (170 microM) markedly attenuated the generation of 1,2 diacylglycerol in neutrophils stimulated with either FMLP plus cytochalasin B or with 20.0 mM NaF.	1,2-diacylglycerol	89-107	C-X-C motif chemokine ligand 8	Homo sapiens	187-190
2055605-6	1991	The assay was able to detect IL-8 when the samples were prepared in either normal saline, RPMI, or human plasma.	rpmi	90-94	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
1899427-10	1991	The production of NAP-1/IL-8 was markedly reduced by dexamethasone in phagocytosis-stimulated PBMC, and almost totally inhibited in SFMC obtained from joints after intraarticular administration of betamethasone.	Dexamethasone	53-66	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
1899427-10	1991	The production of NAP-1/IL-8 was markedly reduced by dexamethasone in phagocytosis-stimulated PBMC, and almost totally inhibited in SFMC obtained from joints after intraarticular administration of betamethasone.	Betamethasone	197-210	C-X-C motif chemokine ligand 8	Homo sapiens	18-23
1899427-10	1991	The production of NAP-1/IL-8 was markedly reduced by dexamethasone in phagocytosis-stimulated PBMC, and almost totally inhibited in SFMC obtained from joints after intraarticular administration of betamethasone.	Betamethasone	197-210	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
1899427-11	1991	By contrast, the cyclooxygenase inhibitor, indomethacin, tended to increase the NAP-1/IL-8 yield from PBMC in culture.	Indomethacin	43-55	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
1899427-11	1991	By contrast, the cyclooxygenase inhibitor, indomethacin, tended to increase the NAP-1/IL-8 yield from PBMC in culture.	Indomethacin	43-55	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
1846901-0	1991	Recombinant human interleukin-8 is a potent activator of canine neutrophil aggregation, migration, and leukotriene B4 biosynthesis.	Leukotriene B4	103-117	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
1848431-4	1991	In this study, we cocultured neutrophils with 35S-sulfate-labeled cartilage and found that the addition of recombinant human IL-8 (rHuIL-8) caused rapid, neutrophil-mediated cartilage degradation that was the result of induction of neutrophil degranulation by the cytokine.	35s-sulfate	46-57	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
1901832-4	1991	The combined incubation of platelets with PCB and sodium fluoride (NaF), an activator of G-proteins, resulted in synergistic 12-HETE generation compared to stimulation with NaF or PCB alone.	Polychlorinated Biphenyls	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
1901832-4	1991	The combined incubation of platelets with PCB and sodium fluoride (NaF), an activator of G-proteins, resulted in synergistic 12-HETE generation compared to stimulation with NaF or PCB alone.	Polychlorinated Biphenyls	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	173-176
1901832-4	1991	The combined incubation of platelets with PCB and sodium fluoride (NaF), an activator of G-proteins, resulted in synergistic 12-HETE generation compared to stimulation with NaF or PCB alone.	Sodium Fluoride	50-65	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
1901832-4	1991	The combined incubation of platelets with PCB and sodium fluoride (NaF), an activator of G-proteins, resulted in synergistic 12-HETE generation compared to stimulation with NaF or PCB alone.	Sodium Fluoride	50-65	C-X-C motif chemokine ligand 8	Homo sapiens	173-176
1901832-4	1991	The combined incubation of platelets with PCB and sodium fluoride (NaF), an activator of G-proteins, resulted in synergistic 12-HETE generation compared to stimulation with NaF or PCB alone.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	125-132	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
1901832-4	1991	The combined incubation of platelets with PCB and sodium fluoride (NaF), an activator of G-proteins, resulted in synergistic 12-HETE generation compared to stimulation with NaF or PCB alone.	Polychlorinated Biphenyls	180-183	C-X-C motif chemokine ligand 8	Homo sapiens	67-70
1899427-7	1991	In addition to LPS, rheumatoid factor-containing immune complexes, zymosan, and IL-1 were highly effective in inducing NAP-1/IL-8 production, while IL-3, GM-CSF, tumor necrosis factor (TNF), and IL-2 were somewhat less potent.	Zymosan	67-74	C-X-C motif chemokine ligand 8	Homo sapiens	119-124
1899427-7	1991	In addition to LPS, rheumatoid factor-containing immune complexes, zymosan, and IL-1 were highly effective in inducing NAP-1/IL-8 production, while IL-3, GM-CSF, tumor necrosis factor (TNF), and IL-2 were somewhat less potent.	Zymosan	67-74	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
1899427-10	1991	The production of NAP-1/IL-8 was markedly reduced by dexamethasone in phagocytosis-stimulated PBMC, and almost totally inhibited in SFMC obtained from joints after intraarticular administration of betamethasone.	Dexamethasone	53-66	C-X-C motif chemokine ligand 8	Homo sapiens	18-23
1790390-1	1991	Fifty-two postmenopausal women (mean age 60 +/- 5 years) with low BMD (less than -2SD of young adult values) but who had not experienced previous crush fracture were treated with 50 mg of sodium fluoride (NaF), 1 g of calcium and 400 IU of vitamin D2 per day for 2 years.	Sodium Fluoride	188-203	C-X-C motif chemokine ligand 8	Homo sapiens	205-208
1703410-6	1991	O2- formation stimulated by complement C5a, concanavalin A, NaF, A 23187, phorbol myristate acetate and arachidonic acid was not affected by Bt2cCMP.	Superoxides	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
1903636-5	1991	Retinoic acid treatment, in a time- and concentration-dependent manner, led to a decrease in phospholipase C activity when stimulated with either GTP gamma S or NaF, both of which activate the enzyme via the G-protein.	Tretinoin	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	161-164
2070378-4	1991	NaF treatment resulted in mean fluoride concentrations of 7,818 ppm.	Fluorides	31-39	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2176614-3	1990	In the presence of poly(dT).r(pA)10 template.primer complex and NaF, we observed AMP, ADP, ATP, PPi and dATP to be competitive inhibitors of the FK-catalyzed DNA polymerization.	Adenosine Monophosphate	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
1752702-2	1991	Exposure of human peripheral blood monocytes to MPG in vitro induced high levels of mRNA transcripts for IL-8 and MCP, as assessed by Northern blot analysis.	(9H-purin-6-yl)thiomethyl glutamate	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
1812910-9	1991	In contrast to the latter effects, a dual-active NaF+MFP dentifrice in a calcium abrasive system exhibited decreased efficacy relative to a silica abrasive formulation due to incompatibility of free fluoride ion.	Calcium	73-80	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
1812910-9	1991	In contrast to the latter effects, a dual-active NaF+MFP dentifrice in a calcium abrasive system exhibited decreased efficacy relative to a silica abrasive formulation due to incompatibility of free fluoride ion.	Fluorides	199-207	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
1937907-1	1991	Simultaneous stimulation of human neutrophils (PMN) with the receptor-mediated activator formyl-met-leu-phe (FMLP) and the G protein activator sodium fluoride (NaF) resulted in the synergistic generation of leukotrienes.	N-Formylmethionine Leucyl-Phenylalanine	89-107	C-X-C motif chemokine ligand 8	Homo sapiens	160-163
1937907-1	1991	Simultaneous stimulation of human neutrophils (PMN) with the receptor-mediated activator formyl-met-leu-phe (FMLP) and the G protein activator sodium fluoride (NaF) resulted in the synergistic generation of leukotrienes.	Sodium Fluoride	143-158	C-X-C motif chemokine ligand 8	Homo sapiens	160-163
1937907-1	1991	Simultaneous stimulation of human neutrophils (PMN) with the receptor-mediated activator formyl-met-leu-phe (FMLP) and the G protein activator sodium fluoride (NaF) resulted in the synergistic generation of leukotrienes.	Leukotrienes	207-219	C-X-C motif chemokine ligand 8	Homo sapiens	160-163
1937907-2	1991	Activation of human platelets with thrombin and NaF showed an additive formation of 12-HETE.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	84-91	C-X-C motif chemokine ligand 8	Homo sapiens	48-51
27467661-4	1991	Included among these is a distinct isoenzyme (group), defined by IEF with acidic isoelectric points (pI) of approximately 6.0, that is characterized by its strong staining intensity and inhibition by sodium fluoride (NaF).	Sodium Fluoride	200-215	C-X-C motif chemokine ligand 8	Homo sapiens	217-220
2176614-3	1990	In the presence of poly(dT).r(pA)10 template.primer complex and NaF, we observed AMP, ADP, ATP, PPi and dATP to be competitive inhibitors of the FK-catalyzed DNA polymerization.	Adenosine Diphosphate	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
2176614-3	1990	In the presence of poly(dT).r(pA)10 template.primer complex and NaF, we observed AMP, ADP, ATP, PPi and dATP to be competitive inhibitors of the FK-catalyzed DNA polymerization.	Adenosine Triphosphate	91-94	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
2176614-3	1990	In the presence of poly(dT).r(pA)10 template.primer complex and NaF, we observed AMP, ADP, ATP, PPi and dATP to be competitive inhibitors of the FK-catalyzed DNA polymerization.	2'-deoxyadenosine triphosphate	104-108	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
2097295-0	1990	Effect of exogenous prostaglandin E2 and actinomycin D on plasma leakage induced by neutrophil-activating peptide-1/interleukin-8.	Dinoprostone	20-36	C-X-C motif chemokine ligand 8	Homo sapiens	84-115
2097295-0	1990	Effect of exogenous prostaglandin E2 and actinomycin D on plasma leakage induced by neutrophil-activating peptide-1/interleukin-8.	Dinoprostone	20-36	C-X-C motif chemokine ligand 8	Homo sapiens	116-129
2097295-0	1990	Effect of exogenous prostaglandin E2 and actinomycin D on plasma leakage induced by neutrophil-activating peptide-1/interleukin-8.	Dactinomycin	41-54	C-X-C motif chemokine ligand 8	Homo sapiens	84-115
2097295-0	1990	Effect of exogenous prostaglandin E2 and actinomycin D on plasma leakage induced by neutrophil-activating peptide-1/interleukin-8.	Dactinomycin	41-54	C-X-C motif chemokine ligand 8	Homo sapiens	116-129
2097295-3	1990	Co-injection of prostaglandin E2 (PGE2) extended the threshold of inflammatory activity of NAP-1/IL-8 to less than 10(-13) moles/site and caused approximately three-fold increases in neutrophil accumulation and ten-fold increases in plasma leakage at the higher doses of NAP-1/IL-8 examined.	Dinoprostone	16-32	C-X-C motif chemokine ligand 8	Homo sapiens	91-96
2097295-3	1990	Co-injection of prostaglandin E2 (PGE2) extended the threshold of inflammatory activity of NAP-1/IL-8 to less than 10(-13) moles/site and caused approximately three-fold increases in neutrophil accumulation and ten-fold increases in plasma leakage at the higher doses of NAP-1/IL-8 examined.	Dinoprostone	16-32	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
2097295-3	1990	Co-injection of prostaglandin E2 (PGE2) extended the threshold of inflammatory activity of NAP-1/IL-8 to less than 10(-13) moles/site and caused approximately three-fold increases in neutrophil accumulation and ten-fold increases in plasma leakage at the higher doses of NAP-1/IL-8 examined.	Dinoprostone	16-32	C-X-C motif chemokine ligand 8	Homo sapiens	271-276
2126013-6	1990	Similar results were obtained when ATP was depleted by incubation of cells either under a N2-atmosphere or in the presence of NaN3 and NaF.	Adenosine Triphosphate	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	135-138
2097295-3	1990	Co-injection of prostaglandin E2 (PGE2) extended the threshold of inflammatory activity of NAP-1/IL-8 to less than 10(-13) moles/site and caused approximately three-fold increases in neutrophil accumulation and ten-fold increases in plasma leakage at the higher doses of NAP-1/IL-8 examined.	Dinoprostone	16-32	C-X-C motif chemokine ligand 8	Homo sapiens	277-281
2097295-3	1990	Co-injection of prostaglandin E2 (PGE2) extended the threshold of inflammatory activity of NAP-1/IL-8 to less than 10(-13) moles/site and caused approximately three-fold increases in neutrophil accumulation and ten-fold increases in plasma leakage at the higher doses of NAP-1/IL-8 examined.	Dinoprostone	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	91-96
2097295-3	1990	Co-injection of prostaglandin E2 (PGE2) extended the threshold of inflammatory activity of NAP-1/IL-8 to less than 10(-13) moles/site and caused approximately three-fold increases in neutrophil accumulation and ten-fold increases in plasma leakage at the higher doses of NAP-1/IL-8 examined.	Dinoprostone	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
2097295-3	1990	Co-injection of prostaglandin E2 (PGE2) extended the threshold of inflammatory activity of NAP-1/IL-8 to less than 10(-13) moles/site and caused approximately three-fold increases in neutrophil accumulation and ten-fold increases in plasma leakage at the higher doses of NAP-1/IL-8 examined.	Dinoprostone	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	271-276
2097295-3	1990	Co-injection of prostaglandin E2 (PGE2) extended the threshold of inflammatory activity of NAP-1/IL-8 to less than 10(-13) moles/site and caused approximately three-fold increases in neutrophil accumulation and ten-fold increases in plasma leakage at the higher doses of NAP-1/IL-8 examined.	Dinoprostone	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	277-281
2173722-5	1990	Release of NAP-1 was stimulus specific because A23187 evoked the release of LTB4 but not NAP-1, whereas LPS and zymosan induced the release of both LTB4 and NAP-1.	Calcimycin	47-53	C-X-C motif chemokine ligand 8	Homo sapiens	11-16
2170531-5	1990	Pretreatment of neutrophils with either GM-CSF or TNF-alpha dose-dependently enhanced the production of superoxide induced by NaF, as determined by the superoxide dismutase-inhibitable reduction of ferricytochrome c.	Superoxides	104-114	C-X-C motif chemokine ligand 8	Homo sapiens	126-129
2173722-0	1990	Macrophages cultured in vitro release leukotriene B4 and neutrophil attractant/activation protein (interleukin 8) sequentially in response to stimulation with lipopolysaccharide and zymosan.	Zymosan	182-189	C-X-C motif chemokine ligand 8	Homo sapiens	99-112
2173722-1	1990	The capacity of lipopolysaccharide (LPS), zymosan, and calcium ionophore A23187 to induce neutrophil chemotactic activity (NCA), leukotriene B4 (LTB4), and neutrophil attractant/activation protein (NAP-1) release from human alveolar macrophages (AM) retrieved from normal nonsmokers was evaluated.	Calcimycin	73-79	C-X-C motif chemokine ligand 8	Homo sapiens	198-203
2173722-5	1990	Release of NAP-1 was stimulus specific because A23187 evoked the release of LTB4 but not NAP-1, whereas LPS and zymosan induced the release of both LTB4 and NAP-1.	Zymosan	112-119	C-X-C motif chemokine ligand 8	Homo sapiens	11-16
2173722-8	1990	Preincubation of AM with nordihydroguiaretic acid (10(-4) M) completely abolished the appearance of NCA, LTB4, and NAP-1 in supernatants of AM challenged with LPS.	Masoprocol	25-49	C-X-C motif chemokine ligand 8	Homo sapiens	115-120
2173722-9	1990	Therefore, LPS and zymosan particles were potent stimuli of the sequential release of LTB4 and NAP-1 from AM.	Zymosan	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	95-100
2170531-5	1990	Pretreatment of neutrophils with either GM-CSF or TNF-alpha dose-dependently enhanced the production of superoxide induced by NaF, as determined by the superoxide dismutase-inhibitable reduction of ferricytochrome c.	Carbon	82-83	C-X-C motif chemokine ligand 8	Homo sapiens	126-129
2212672-4	1990	The IL-8 isolated from each of these cell types is a mixture of two IL-8 polypeptides, one consisting of 72 amino acids (herein called [ser-IL-8]72) and the other 77 amino acids (an N-terminal extended form herein called [ala-IL-8]77).	Serine	136-139	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
2212672-4	1990	The IL-8 isolated from each of these cell types is a mixture of two IL-8 polypeptides, one consisting of 72 amino acids (herein called [ser-IL-8]72) and the other 77 amino acids (an N-terminal extended form herein called [ala-IL-8]77).	Alanine	222-225	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
2212672-12	1990	Both forms of IL-8 promoted degranulation of cytochalasin B-treated neutrophils [[ser-IL-8]72 (ED50 greater than 10 nM) was two- to three-fold more potent than [ala-IL-8]77], although in this regard they were less active than FMLP.	Cytochalasin B	45-59	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
2096385-1	1990	Cytotoxicity of sodium fluoride (NaF) on human diploid cells in exponential growth was investigated using a) Flow 1000 cells, passage No.	Sodium Fluoride	16-31	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
2212672-12	1990	Both forms of IL-8 promoted degranulation of cytochalasin B-treated neutrophils [[ser-IL-8]72 (ED50 greater than 10 nM) was two- to three-fold more potent than [ala-IL-8]77], although in this regard they were less active than FMLP.	Serine	82-85	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
2212672-12	1990	Both forms of IL-8 promoted degranulation of cytochalasin B-treated neutrophils [[ser-IL-8]72 (ED50 greater than 10 nM) was two- to three-fold more potent than [ala-IL-8]77], although in this regard they were less active than FMLP.	Serine	82-85	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
2212672-12	1990	Both forms of IL-8 promoted degranulation of cytochalasin B-treated neutrophils [[ser-IL-8]72 (ED50 greater than 10 nM) was two- to three-fold more potent than [ala-IL-8]77], although in this regard they were less active than FMLP.	Serine	82-85	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
2212672-12	1990	Both forms of IL-8 promoted degranulation of cytochalasin B-treated neutrophils [[ser-IL-8]72 (ED50 greater than 10 nM) was two- to three-fold more potent than [ala-IL-8]77], although in this regard they were less active than FMLP.	Alanine	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
2212672-12	1990	Both forms of IL-8 promoted degranulation of cytochalasin B-treated neutrophils [[ser-IL-8]72 (ED50 greater than 10 nM) was two- to three-fold more potent than [ala-IL-8]77], although in this regard they were less active than FMLP.	Alanine	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
2212672-12	1990	Both forms of IL-8 promoted degranulation of cytochalasin B-treated neutrophils [[ser-IL-8]72 (ED50 greater than 10 nM) was two- to three-fold more potent than [ala-IL-8]77], although in this regard they were less active than FMLP.	Alanine	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
2212672-13	1990	Our data suggest that [ala-IL-8]77 and [ser-IL-8]72 have qualitatively similar and potentially complex biological activities, and that full activation of IL-8 requires cleavage to the [ser-IL-8]72 form.	Alanine	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
2212672-13	1990	Our data suggest that [ala-IL-8]77 and [ser-IL-8]72 have qualitatively similar and potentially complex biological activities, and that full activation of IL-8 requires cleavage to the [ser-IL-8]72 form.	Serine	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
2212672-13	1990	Our data suggest that [ala-IL-8]77 and [ser-IL-8]72 have qualitatively similar and potentially complex biological activities, and that full activation of IL-8 requires cleavage to the [ser-IL-8]72 form.	Serine	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
2212672-13	1990	Our data suggest that [ala-IL-8]77 and [ser-IL-8]72 have qualitatively similar and potentially complex biological activities, and that full activation of IL-8 requires cleavage to the [ser-IL-8]72 form.	Serine	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
2212672-13	1990	Our data suggest that [ala-IL-8]77 and [ser-IL-8]72 have qualitatively similar and potentially complex biological activities, and that full activation of IL-8 requires cleavage to the [ser-IL-8]72 form.	Serine	185-188	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
2212672-5	1990	IL-8 derived from T lymphocytes and monocytes is predominantly [ser-IL-8]72, whereas endothelial-derived IL-8 is highly enriched (greater than 80%) in [ala-IL-8]77.	Serine	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
2212672-5	1990	IL-8 derived from T lymphocytes and monocytes is predominantly [ser-IL-8]72, whereas endothelial-derived IL-8 is highly enriched (greater than 80%) in [ala-IL-8]77.	Serine	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
2212672-5	1990	IL-8 derived from T lymphocytes and monocytes is predominantly [ser-IL-8]72, whereas endothelial-derived IL-8 is highly enriched (greater than 80%) in [ala-IL-8]77.	Serine	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
2212672-5	1990	IL-8 derived from T lymphocytes and monocytes is predominantly [ser-IL-8]72, whereas endothelial-derived IL-8 is highly enriched (greater than 80%) in [ala-IL-8]77.	Serine	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
2212672-7	1990	Thrombin was found to efficiently convert [ala-IL-8]77 to [ser-IL-8]72.	Alanine	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
2212672-7	1990	Thrombin was found to efficiently convert [ala-IL-8]77 to [ser-IL-8]72.	Alanine	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
2212672-7	1990	Thrombin was found to efficiently convert [ala-IL-8]77 to [ser-IL-8]72.	Serine	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
2212672-7	1990	Thrombin was found to efficiently convert [ala-IL-8]77 to [ser-IL-8]72.	Serine	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
2212672-9	1990	In competitive binding assays using 125I[ala-IL-8]77 neutrophils exhibited a twofold preference for [ser-IL-8]72 over [ala-IL-8]77.	Alanine	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
2212672-9	1990	In competitive binding assays using 125I[ala-IL-8]77 neutrophils exhibited a twofold preference for [ser-IL-8]72 over [ala-IL-8]77.	Alanine	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
2212672-9	1990	In competitive binding assays using 125I[ala-IL-8]77 neutrophils exhibited a twofold preference for [ser-IL-8]72 over [ala-IL-8]77.	Alanine	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
2212672-9	1990	In competitive binding assays using 125I[ala-IL-8]77 neutrophils exhibited a twofold preference for [ser-IL-8]72 over [ala-IL-8]77.	Serine	101-104	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
2212672-9	1990	In competitive binding assays using 125I[ala-IL-8]77 neutrophils exhibited a twofold preference for [ser-IL-8]72 over [ala-IL-8]77.	Serine	101-104	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
2212672-9	1990	In competitive binding assays using 125I[ala-IL-8]77 neutrophils exhibited a twofold preference for [ser-IL-8]72 over [ala-IL-8]77.	Serine	101-104	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
2212672-11	1990	However, [ser-IL-8]72 was approximately 10-fold more potent than [ala-IL-8]77 in these assays (ED50 approximately 0.3 nM for [ser-IL-8]72 vs approximately 3 nM for [ala-IL-8]77.	Serine	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
2212672-11	1990	However, [ser-IL-8]72 was approximately 10-fold more potent than [ala-IL-8]77 in these assays (ED50 approximately 0.3 nM for [ser-IL-8]72 vs approximately 3 nM for [ala-IL-8]77.	Alanine	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
2212672-11	1990	However, [ser-IL-8]72 was approximately 10-fold more potent than [ala-IL-8]77 in these assays (ED50 approximately 0.3 nM for [ser-IL-8]72 vs approximately 3 nM for [ala-IL-8]77.	Alanine	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
2212672-11	1990	However, [ser-IL-8]72 was approximately 10-fold more potent than [ala-IL-8]77 in these assays (ED50 approximately 0.3 nM for [ser-IL-8]72 vs approximately 3 nM for [ala-IL-8]77.	Alanine	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
2212672-11	1990	However, [ser-IL-8]72 was approximately 10-fold more potent than [ala-IL-8]77 in these assays (ED50 approximately 0.3 nM for [ser-IL-8]72 vs approximately 3 nM for [ala-IL-8]77.	Serine	126-129	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
2212672-12	1990	Both forms of IL-8 promoted degranulation of cytochalasin B-treated neutrophils [[ser-IL-8]72 (ED50 greater than 10 nM) was two- to three-fold more potent than [ala-IL-8]77], although in this regard they were less active than FMLP.	Cytochalasin B	45-59	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
2212672-12	1990	Both forms of IL-8 promoted degranulation of cytochalasin B-treated neutrophils [[ser-IL-8]72 (ED50 greater than 10 nM) was two- to three-fold more potent than [ala-IL-8]77], although in this regard they were less active than FMLP.	Cytochalasin B	45-59	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
1699135-3	1990	Interleukin-8 is a chemoattractant for T cells and neutrophils and is a member of a superfamily of soluble molecules related by a conserved motif containing four cysteine residues.	Cysteine	162-170	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
2241978-3	1990	Purification by anti NAP-1/IL-8 affinity chromatography and reversed phase HPLC revealed a single peak showing a single line upon SDS-PAGE corresponding to a Mr of 8000.	Sodium Dodecyl Sulfate	130-133	C-X-C motif chemokine ligand 8	Homo sapiens	21-26
2241978-3	1990	Purification by anti NAP-1/IL-8 affinity chromatography and reversed phase HPLC revealed a single peak showing a single line upon SDS-PAGE corresponding to a Mr of 8000.	Sodium Dodecyl Sulfate	130-133	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
2136468-6	1990	The combination of calcium, small doses of vitamin D, NaF and exercise used in the treatment of diabetic osteoporoses leads in general to a significant rise of the calcium serum level, an insignificant rise of the phosphorus level and it reduces alkaline phosphatase activity.	Calcium	164-171	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
2080951-11	1990	After administration of the products, fluoride appeared in blood with a lag time smaller than 0.05 h and invaded the blood with a t1/2 from 0.07 to 0.12 h. The Cmax of fluoride in plasma was 412-466 ng/ml at a tmax of 0.5-0.7 h. The AUCs of fluoride after Na2FPO3 solution and after Na2FPO3 tablets were within the 0.80-1.20 bioequivalence limits with regard to the AUC after NaF solution.	Fluorides	168-176	C-X-C motif chemokine ligand 8	Homo sapiens	376-379
2080951-11	1990	After administration of the products, fluoride appeared in blood with a lag time smaller than 0.05 h and invaded the blood with a t1/2 from 0.07 to 0.12 h. The Cmax of fluoride in plasma was 412-466 ng/ml at a tmax of 0.5-0.7 h. The AUCs of fluoride after Na2FPO3 solution and after Na2FPO3 tablets were within the 0.80-1.20 bioequivalence limits with regard to the AUC after NaF solution.	Fluorides	168-176	C-X-C motif chemokine ligand 8	Homo sapiens	376-379
2080951-13	1990	In the 24 h following the administration, the urinary excretion of fluoride accounted for 51 +/- 10%, 46 +/- 6% and 47 +/- 8% of the administered dose, respectively for NaF solution, Na2FPO3 solution and Na2FPO3 + Ca tablets.	Fluorides	67-75	C-X-C motif chemokine ligand 8	Homo sapiens	169-172
2200823-7	1990	The IL-4-induced inhibition of IL-8 mRNA expression was dependent on protein synthesis, as the suppressive effects of IL-4 were significantly negated by the addition of cycloheximide.	Cycloheximide	169-182	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
2134272-9	1990	The most commonly used fluoride mouth-rinsing solution for daily use is 0.05-0.1% NaF in neutral or weak acid solution.	Fluorides	23-31	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
2134272-9	1990	The most commonly used fluoride mouth-rinsing solution for daily use is 0.05-0.1% NaF in neutral or weak acid solution.	weak acid	100-109	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
9995899-0	1990	Excited-state absorption by Eu2+ in NaF and KMgF3.	europium(2+)	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	36-39
2148657-2	1990	NaF (mM) completely inhibits the Ca-ATP-ase activity in presence of 0.02% tween-20.	Polysorbates	74-82	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2148657-3	1990	The inhibition is time- and NaF-concentration-dependent and increases as affected by AlCl3 (microM).	Aluminum Chloride	85-90	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
2148657-4	1990	The potentiated action of AlCl3 depends on the NaF concentration.	Aluminum Chloride	26-31	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
2148657-6	1990	NaF inhibits the Ca-ATP-ase competitively with respect to ATP, but NaF plus AlCl3 make the inhibition combined.	Adenosine Triphosphate	20-23	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2148657-7	1990	The affinity of the Ca-ATP-ase to the NaF + AlCl3 complex, but not to NaF decreases by 5 mM with an increase of the Pi concentration.	Aluminum Chloride	44-49	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
2148657-8	1990	NaF probably interacts with the ATP-binding site and the NaF + AlCl3 complex interacts with the phosphate-binding site of the ATP-ase.	Adenosine Triphosphate	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2148657-8	1990	NaF probably interacts with the ATP-binding site and the NaF + AlCl3 complex interacts with the phosphate-binding site of the ATP-ase.	Aluminum Chloride	63-68	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
2148657-8	1990	NaF probably interacts with the ATP-binding site and the NaF + AlCl3 complex interacts with the phosphate-binding site of the ATP-ase.	Phosphates	96-105	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
2384626-7	1990	The slabs treated with 2% NaF and then with 1 mol/L KOH would contain the KOH-insoluble fluoride.	potassium hydroxide	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
2384626-7	1990	The slabs treated with 2% NaF and then with 1 mol/L KOH would contain the KOH-insoluble fluoride.	Fluorides	88-96	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
2384626-8	1990	Those treated with only 2% NaF would, in addition, contain KOH-soluble fluoride.	potassium hydroxide	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
2384626-8	1990	Those treated with only 2% NaF would, in addition, contain KOH-soluble fluoride.	Fluorides	71-79	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
2168414-3	1990	Although NaF induced the mobilization of Ca2+ from intracellular storage sites in fura2-loaded platelets, it failed to raise pHi as determined from the fluorescence of 2,7-bis-(2-carboxyethyl)-5(6)-carboxyfluorescein-loaded platelets.	Fura-2	82-87	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
2168414-4	1990	Furthermore, when thrombin (0.1 unit/ml) or the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) had raised pHi from 7.13 +/- 0.05 to 7.35 +/- 0.07 (n = 30), addition of NaF (2.5-10 mM) rapidly restored pHi to values found before stimulation.	Tetradecanoylphorbol Acetate	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	178-181
2168414-5	1990	Conversely, preincubation of platelets with low concentrations of NaF (2.5 mM) completely prevented alkalinization in response to thrombin or TPA.	Tetradecanoylphorbol Acetate	142-145	C-X-C motif chemokine ligand 8	Homo sapiens	66-69
2168414-8	1990	In order to investigate whether the NaF effect was attributable to a G protein, platelets were preincubated with N-ethylmaleimide (50 microM), which is known to inhibit the adenylyl cyclase-inhibitory G protein.	Ethylmaleimide	113-129	C-X-C motif chemokine ligand 8	Homo sapiens	36-39
2168414-9	1990	N-Ethylmaleimide treatment not only prevented inhibition of adenylyl cyclase by epinephrine but also completely reversed the inhibitory effect of NaF on the Na+/H+ exchanger.	Ethylmaleimide	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	146-149
2384166-1	1990	Activation of transducin-GDP by NaF is mainly mediated by aluminofluorde or beryllofluoride complexes acting as GTP gamma-phosphate analogs.	aluminofluorde	58-72	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
2384166-1	1990	Activation of transducin-GDP by NaF is mainly mediated by aluminofluorde or beryllofluoride complexes acting as GTP gamma-phosphate analogs.	beryllium fluoride	76-91	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
2136468-6	1990	The combination of calcium, small doses of vitamin D, NaF and exercise used in the treatment of diabetic osteoporoses leads in general to a significant rise of the calcium serum level, an insignificant rise of the phosphorus level and it reduces alkaline phosphatase activity.	Phosphorus	214-224	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
2162138-3	1990	Inhibition of isoproterenol-sensitive adenylate cyclase activity could be demonstrated by serum dilutions or IgG in 52% (26 of 50) of the patients; basal and NaF-stimulated activities, in contrast, were unaffected.	Isoproterenol	14-27	C-X-C motif chemokine ligand 8	Homo sapiens	158-161
2384166-1	1990	Activation of transducin-GDP by NaF is mainly mediated by aluminofluorde or beryllofluoride complexes acting as GTP gamma-phosphate analogs.	gtp gamma-phosphate	112-131	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
2384166-2	1990	In millimolar magnesium, NaF at concentrations above 3 mM is active even in the absence of aluminium or beryllium.	Magnesium	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
2384166-2	1990	In millimolar magnesium, NaF at concentrations above 3 mM is active even in the absence of aluminium or beryllium.	Aluminum	91-100	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
2384166-2	1990	In millimolar magnesium, NaF at concentrations above 3 mM is active even in the absence of aluminium or beryllium.	Beryllium	104-113	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
2384166-5	1990	We propose that at high NaF concentrations, 3 hydrogen-bonded fluorides in the gamma-phosphate site of T alpha GDP entrap a magnesium counterion and this induces the transconformation to the T alpha GTP form.	Hydrogen	46-54	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
2384166-5	1990	We propose that at high NaF concentrations, 3 hydrogen-bonded fluorides in the gamma-phosphate site of T alpha GDP entrap a magnesium counterion and this induces the transconformation to the T alpha GTP form.	Fluorides	62-71	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
2384166-5	1990	We propose that at high NaF concentrations, 3 hydrogen-bonded fluorides in the gamma-phosphate site of T alpha GDP entrap a magnesium counterion and this induces the transconformation to the T alpha GTP form.	Phosphates	85-94	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
2384166-5	1990	We propose that at high NaF concentrations, 3 hydrogen-bonded fluorides in the gamma-phosphate site of T alpha GDP entrap a magnesium counterion and this induces the transconformation to the T alpha GTP form.	Guanosine Diphosphate	111-114	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
2384166-5	1990	We propose that at high NaF concentrations, 3 hydrogen-bonded fluorides in the gamma-phosphate site of T alpha GDP entrap a magnesium counterion and this induces the transconformation to the T alpha GTP form.	Magnesium	124-133	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
2384166-5	1990	We propose that at high NaF concentrations, 3 hydrogen-bonded fluorides in the gamma-phosphate site of T alpha GDP entrap a magnesium counterion and this induces the transconformation to the T alpha GTP form.	Guanosine Triphosphate	199-202	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
2133180-5	1990	Taking a value of 1.00 for F absorption from sodium fluoride (NaF) in water, relative values of 0.58 and 0.32 were obtained for tea ingestion on a fasting stomach, and together with solid food, respectively.	Water	70-75	C-X-C motif chemokine ligand 8	Homo sapiens	62-65
2386484-1	1990	In isolated cells from the avian supra-orbital nasal gland, used as a model for exocrine ion secretion, addition of NaF (2-15 mM) produced a slow Al3(+)-enhanced increase in intracellular Ca2+ concn.	al3(+)	146-152	C-X-C motif chemokine ligand 8	Homo sapiens	116-119
2163626-1	1990	Potent inhibition of IL-8-induced PBL migration was observed following exposure of PBL to PTX and CTX (1 pM to 0.1 microM), 8-bromo cyclic adenosine monophosphate (cAMP; 1 nM to 1 microM), H7 (1 pM to 0.1 microM), sphingosine (0.1 microM to 100 microM) and the novel pkC inhibitors Ro 31-7549 and Ro 31-8220 (10 pM to 1 microM) for 10 min.	8-Bromo Cyclic Adenosine Monophosphate	124-162	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
2163626-1	1990	Potent inhibition of IL-8-induced PBL migration was observed following exposure of PBL to PTX and CTX (1 pM to 0.1 microM), 8-bromo cyclic adenosine monophosphate (cAMP; 1 nM to 1 microM), H7 (1 pM to 0.1 microM), sphingosine (0.1 microM to 100 microM) and the novel pkC inhibitors Ro 31-7549 and Ro 31-8220 (10 pM to 1 microM) for 10 min.	Cyclic AMP	164-168	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
2163626-1	1990	Potent inhibition of IL-8-induced PBL migration was observed following exposure of PBL to PTX and CTX (1 pM to 0.1 microM), 8-bromo cyclic adenosine monophosphate (cAMP; 1 nM to 1 microM), H7 (1 pM to 0.1 microM), sphingosine (0.1 microM to 100 microM) and the novel pkC inhibitors Ro 31-7549 and Ro 31-8220 (10 pM to 1 microM) for 10 min.	Sphingosine	214-225	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
2133180-7	1990	Through another bioavailability experiment it was shown that the absorption of F (from MFP) in milk, is as high as that of F (from NaF) in water.	Water	139-144	C-X-C motif chemokine ligand 8	Homo sapiens	131-134
1692318-1	1990	Treatment of intact human umbilical vein endothelial cells with NaF results in a dose-dependent biphasic response in both prostacyclin and inositol phosphate production: the stimulation observed with 10-20 mM NaF decreases with higher concentrations.	Epoprostenol	122-134	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
2161898-3	1990	Fibrosarcoma-derived MCAF specifically competed with THP-1 (a human monocytic cell line)-derived 125I-labeled MCAF in binding to human PBMC, whereas a similar basic heparin-binding leukocyte chemoattractant, IL-8, did not.	Iodine-125	97-101	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
1692318-1	1990	Treatment of intact human umbilical vein endothelial cells with NaF results in a dose-dependent biphasic response in both prostacyclin and inositol phosphate production: the stimulation observed with 10-20 mM NaF decreases with higher concentrations.	Epoprostenol	122-134	C-X-C motif chemokine ligand 8	Homo sapiens	209-212
1692318-4	1990	Guanosine 5"-O-(3-thiotriphosphate) (GTP gamma S) also causes a dose-dependent biphasic response in inositol phosphate formation in permeabilized cells and homogenates; a higher inhibitory concentration of GTP gamma S abolishes the stimulation of inositol phosphate production by low NaF concentrations.	Guanosine 5'-O-(3-Thiotriphosphate)	0-35	C-X-C motif chemokine ligand 8	Homo sapiens	284-287
1692318-4	1990	Guanosine 5"-O-(3-thiotriphosphate) (GTP gamma S) also causes a dose-dependent biphasic response in inositol phosphate formation in permeabilized cells and homogenates; a higher inhibitory concentration of GTP gamma S abolishes the stimulation of inositol phosphate production by low NaF concentrations.	Guanosine 5'-O-(3-Thiotriphosphate)	37-48	C-X-C motif chemokine ligand 8	Homo sapiens	284-287
1692318-1	1990	Treatment of intact human umbilical vein endothelial cells with NaF results in a dose-dependent biphasic response in both prostacyclin and inositol phosphate production: the stimulation observed with 10-20 mM NaF decreases with higher concentrations.	Inositol Phosphates	139-157	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
1692318-4	1990	Guanosine 5"-O-(3-thiotriphosphate) (GTP gamma S) also causes a dose-dependent biphasic response in inositol phosphate formation in permeabilized cells and homogenates; a higher inhibitory concentration of GTP gamma S abolishes the stimulation of inositol phosphate production by low NaF concentrations.	Inositol Phosphates	100-118	C-X-C motif chemokine ligand 8	Homo sapiens	284-287
1692318-4	1990	Guanosine 5"-O-(3-thiotriphosphate) (GTP gamma S) also causes a dose-dependent biphasic response in inositol phosphate formation in permeabilized cells and homogenates; a higher inhibitory concentration of GTP gamma S abolishes the stimulation of inositol phosphate production by low NaF concentrations.	Guanosine Triphosphate	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	284-287
2186041-2	1990	This polypeptide has been iodinated by chloramine-T methodology (350 Ci/mM), and specific receptors for MDNCF/IL-8 have been detected on human neutrophils, U937 cells, THP-1 cells, and dimethyl sulfoxide-differentiated HL-60 cells.	Dimethyl Sulfoxide	185-203	C-X-C motif chemokine ligand 8	Homo sapiens	104-109
1692318-1	1990	Treatment of intact human umbilical vein endothelial cells with NaF results in a dose-dependent biphasic response in both prostacyclin and inositol phosphate production: the stimulation observed with 10-20 mM NaF decreases with higher concentrations.	Inositol Phosphates	139-157	C-X-C motif chemokine ligand 8	Homo sapiens	209-212
2186041-2	1990	This polypeptide has been iodinated by chloramine-T methodology (350 Ci/mM), and specific receptors for MDNCF/IL-8 have been detected on human neutrophils, U937 cells, THP-1 cells, and dimethyl sulfoxide-differentiated HL-60 cells.	Dimethyl Sulfoxide	185-203	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
1692318-4	1990	Guanosine 5"-O-(3-thiotriphosphate) (GTP gamma S) also causes a dose-dependent biphasic response in inositol phosphate formation in permeabilized cells and homogenates; a higher inhibitory concentration of GTP gamma S abolishes the stimulation of inositol phosphate production by low NaF concentrations.	Sulfur	47-48	C-X-C motif chemokine ligand 8	Homo sapiens	284-287
1692318-5	1990	A high concentration of NaF furthermore inhibits the non-G-protein-dependent activation of phospholipase C by deoxycholate.	Deoxycholic Acid	110-122	C-X-C motif chemokine ligand 8	Homo sapiens	24-27
2186041-5	1990	The receptor for MDNCF/IL-8 is apparently glycosylated since ligand binding is inhibited by the presence of wheat germ agglutinin, a lectin with a binding specificity for N-acetylglucosamine and neuraminic acid.	Acetylglucosamine	171-190	C-X-C motif chemokine ligand 8	Homo sapiens	17-22
1692318-2	1990	High concentrations of NaF furthermore reduce thrombin- or A23187-stimulated prostacyclin production.	Calcimycin	59-65	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
2186041-5	1990	The receptor for MDNCF/IL-8 is apparently glycosylated since ligand binding is inhibited by the presence of wheat germ agglutinin, a lectin with a binding specificity for N-acetylglucosamine and neuraminic acid.	Acetylglucosamine	171-190	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
1692318-6	1990	NaF also induces a dose-dependent biphasic response in cyclic AMP formation in intact cells, indicating that the inhibition of phospholipase C at higher NaF concentrations does not result from a rise in cyclic AMP.	Cyclic AMP	55-65	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2186041-5	1990	The receptor for MDNCF/IL-8 is apparently glycosylated since ligand binding is inhibited by the presence of wheat germ agglutinin, a lectin with a binding specificity for N-acetylglucosamine and neuraminic acid.	Neuraminic Acids	195-210	C-X-C motif chemokine ligand 8	Homo sapiens	17-22
2186041-5	1990	The receptor for MDNCF/IL-8 is apparently glycosylated since ligand binding is inhibited by the presence of wheat germ agglutinin, a lectin with a binding specificity for N-acetylglucosamine and neuraminic acid.	Neuraminic Acids	195-210	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
2186041-7	1990	125I-MDNCF/IL-8 bound to human neutrophils is rapidly internalized and subsequently released from cells as trichloroacetic acid-soluble radioactivity.	Trichloroacetic Acid	107-127	C-X-C motif chemokine ligand 8	Homo sapiens	5-10
2186041-7	1990	125I-MDNCF/IL-8 bound to human neutrophils is rapidly internalized and subsequently released from cells as trichloroacetic acid-soluble radioactivity.	Trichloroacetic Acid	107-127	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
1692318-2	1990	High concentrations of NaF furthermore reduce thrombin- or A23187-stimulated prostacyclin production.	Epoprostenol	77-89	C-X-C motif chemokine ligand 8	Homo sapiens	23-26
1692318-3	1990	Direct assay of phospholipase C activity in cell homogenates shows a similar biphasic response to NaF, also after chelation of Ca2+; addition of AlCl3 shifts the inhibition toward lower NaF concentrations.	Aluminum Chloride	145-150	C-X-C motif chemokine ligand 8	Homo sapiens	98-101
1692318-3	1990	Direct assay of phospholipase C activity in cell homogenates shows a similar biphasic response to NaF, also after chelation of Ca2+; addition of AlCl3 shifts the inhibition toward lower NaF concentrations.	Aluminum Chloride	145-150	C-X-C motif chemokine ligand 8	Homo sapiens	186-189
2096963-1	1990	The formulation for the controlled release of NaF from matrix tablets using Methyl cellulose to prepare chewable NaF tablets for the prevention of dental caries is developed.	Methylcellulose	76-92	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
2110856-1	1990	The oral administration of sodium fluoride (NaF) (40 mumol/100 body weight [bw]) to fasting rats produced an immediate fall in insulin levels and the consequent increase in glycemia.	Sodium Fluoride	27-42	C-X-C motif chemokine ligand 8	Homo sapiens	44-47
2110856-5	1990	One hour after the intake of 60 mg of NaF, fasting human volunteers showed increased fluoride (5-15 microM) together with a significant fall of plasma insulin levels.	Fluorides	85-93	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
2328269-2	1990	Basal and forskolin-stimulated adenylate cyclase activity were significantly lower in the PTSD group whereas aluminum chloride plus sodium fluoride (AlCl3/NaF)- and prostaglandin E1 (PGE1)-stimulated responses were normal.	Sodium Fluoride	132-147	C-X-C motif chemokine ligand 8	Homo sapiens	155-158
2096963-1	1990	The formulation for the controlled release of NaF from matrix tablets using Methyl cellulose to prepare chewable NaF tablets for the prevention of dental caries is developed.	Methylcellulose	76-92	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
2324203-3	1990	The FRED was shown to act as a signal sequence, targeting NAF to the lumen of the ER, by the fact that NAF acquired N-linked carbohydrate chains.	n-linked carbohydrate	116-137	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
2324203-3	1990	The FRED was shown to act as a signal sequence, targeting NAF to the lumen of the ER, by the fact that NAF acquired N-linked carbohydrate chains.	n-linked carbohydrate	116-137	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
2324203-6	1990	By using a combination of sedimentation velocity centrifugation and immunoprecipitation assays using polyclonal and conformation-specific monoclonal antibodies it was found that extracellular NAF consisted of a mixture of monomers, disulfide-linked dimers, and tetramers.	Disulfides	232-241	C-X-C motif chemokine ligand 8	Homo sapiens	192-195
2329325-4	1990	The decrease in glucose concentration was less with increasing amounts of NaF but could not be totally abolished.	Glucose	16-23	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
2182761-4	1990	Tricine-SDS-PAGE analysis gave a single line at Mr 5.3 kD (NAP-1/IL-8 = 5.8 kD).	Tricine SDS	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	59-64
2182761-4	1990	Tricine-SDS-PAGE analysis gave a single line at Mr 5.3 kD (NAP-1/IL-8 = 5.8 kD).	Tricine SDS	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
2155963-9	1990	Enhancement of PMN anti-Candida activity and release of azurophilic enzymes from PMN by MDNCF/IL-8 were inhibited in the presence of colchicine, which is a known inhibitor of degranulation.	Colchicine	133-143	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
2155963-10	1990	These results suggest that MDNCF/IL-8 induced antifungal action of PMN via oxygen-independent pathways.	Oxygen	75-81	C-X-C motif chemokine ligand 8	Homo sapiens	27-32
2155963-10	1990	These results suggest that MDNCF/IL-8 induced antifungal action of PMN via oxygen-independent pathways.	Oxygen	75-81	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
2155963-11	1990	Furthermore, MDNCF/IL-8 induction of anti-Candida action by PMN was inhibited by pretreatment with Bordetella pertussis toxin, suggesting that enhancement of PMN antifungal activity by MDNCF/IL-8, as well as by FMLP, may be mediated by a GTP-binding protein.	Guanosine Triphosphate	238-241	C-X-C motif chemokine ligand 8	Homo sapiens	13-18
2155963-11	1990	Furthermore, MDNCF/IL-8 induction of anti-Candida action by PMN was inhibited by pretreatment with Bordetella pertussis toxin, suggesting that enhancement of PMN antifungal activity by MDNCF/IL-8, as well as by FMLP, may be mediated by a GTP-binding protein.	Guanosine Triphosphate	238-241	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
2155963-11	1990	Furthermore, MDNCF/IL-8 induction of anti-Candida action by PMN was inhibited by pretreatment with Bordetella pertussis toxin, suggesting that enhancement of PMN antifungal activity by MDNCF/IL-8, as well as by FMLP, may be mediated by a GTP-binding protein.	Guanosine Triphosphate	238-241	C-X-C motif chemokine ligand 8	Homo sapiens	185-190
2155963-11	1990	Furthermore, MDNCF/IL-8 induction of anti-Candida action by PMN was inhibited by pretreatment with Bordetella pertussis toxin, suggesting that enhancement of PMN antifungal activity by MDNCF/IL-8, as well as by FMLP, may be mediated by a GTP-binding protein.	Guanosine Triphosphate	238-241	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
2339639-1	1990	To assess whether an interval of a few hours would be advisable between an intake of sodium fluoride (NaF) and that of calcium salts when treating osteoporotic patients with vertebral collapse, we carried out three pharmacokinetic studies in 12 healthy fasting volunteer subjects to compare the fluoride bioavailability provided by NaF alone and NaF combined with two calcium salts.	Sodium Fluoride	85-100	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
2339639-1	1990	To assess whether an interval of a few hours would be advisable between an intake of sodium fluoride (NaF) and that of calcium salts when treating osteoporotic patients with vertebral collapse, we carried out three pharmacokinetic studies in 12 healthy fasting volunteer subjects to compare the fluoride bioavailability provided by NaF alone and NaF combined with two calcium salts.	Fluorides	92-100	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
2339639-2	1990	The results were as follows: (1) When NaF is accompanied by calcium, the fluoride peak level is lower and delayed.	Calcium	60-67	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
2155963-8	1990	However, MDNCF/IL-8 was capable of releasing azurophilic enzymes from cytochalasin B-treated PMN into the extracellular space.	Cytochalasin B	70-84	C-X-C motif chemokine ligand 8	Homo sapiens	9-14
2155963-8	1990	However, MDNCF/IL-8 was capable of releasing azurophilic enzymes from cytochalasin B-treated PMN into the extracellular space.	Cytochalasin B	70-84	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
2155963-9	1990	Enhancement of PMN anti-Candida activity and release of azurophilic enzymes from PMN by MDNCF/IL-8 were inhibited in the presence of colchicine, which is a known inhibitor of degranulation.	Colchicine	133-143	C-X-C motif chemokine ligand 8	Homo sapiens	88-93
2339639-2	1990	The results were as follows: (1) When NaF is accompanied by calcium, the fluoride peak level is lower and delayed.	Fluorides	73-81	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
2339624-5	1990	Urinary fluoride levels were higher in the MFP than in the NaF group (9.6 +/- 3.5 vs. 6.8 +/- 3.4 at one year, p = 0.003), suggesting that this difference in efficacy and tolerance is related to a better bioavailability of fluoride provided by MFP than by NaF.	Fluorides	8-16	C-X-C motif chemokine ligand 8	Homo sapiens	59-62
2339639-4	1990	(3) The areas under the curves obtained with each of the three preparations were not significantly different, but 24-h urinary fluoride was significantly lower in volunteers receiving simultaneously NaF and calcium salts than in volunteers receiving only NaF.	Fluorides	127-135	C-X-C motif chemokine ligand 8	Homo sapiens	199-202
2339640-1	1990	The gastrointestinal absorption of enteric-coated (EC) tablets of sodium fluoride (NaF) with respect to different time schedules of administration of calcium supplements in solution was tested.	Sodium Fluoride	66-81	C-X-C motif chemokine ligand 8	Homo sapiens	83-86
2153604-8	1990	The increase of intracellular cAMP levels caused by dibutyryl cAMP (5 x 10(-4) M), Ro-20 1724 (10(-4) M), forskolin (5 x 10(-6) M), NaF (2 x 10(-3) M) reduced, but MIX (5 x 10(-5) M) increased tritium release elicited by ES and K+.	Cyclic AMP	30-34	C-X-C motif chemokine ligand 8	Homo sapiens	132-135
2302176-3	1990	With 10 mM-NaF, a concentration unable to induce any measurable Ca2+ mobilization (as measured with Indo 1), addition of AlCl3 potentiated platelet aggregation, thromboxane synthesis, diacylglycerol formation and p43 phosphorylation, without any increase in intracellular Ca2+.	Aluminum Chloride	121-126	C-X-C motif chemokine ligand 8	Homo sapiens	11-14
2403554-3	1990	The radiolabeled MDNCF/IL 8 molecules after internalization were proteolytically degraded, and trichloroacetic acid-soluble molecules were released into the culture medium starting at 60 min.	Trichloroacetic Acid	95-115	C-X-C motif chemokine ligand 8	Homo sapiens	17-22
2403554-8	1990	Ammonium chloride reduced the MDNCF/IL 8-induced neutrophil chemotactic response in a dose-dependent fashion.	Ammonium Chloride	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	30-35
2403554-8	1990	Ammonium chloride reduced the MDNCF/IL 8-induced neutrophil chemotactic response in a dose-dependent fashion.	Ammonium Chloride	0-17	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
1966131-0	1990	Production of superoxide anion and hydrogen peroxide by human neutrophilic granulocytes during chemotactic migration towards f-Met-Leu-Phe, C5a, leukotriene B4, monocyte-derived chemotaxin/IL-8 and platelet-activating factor.	Superoxides	14-30	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
1966131-0	1990	Production of superoxide anion and hydrogen peroxide by human neutrophilic granulocytes during chemotactic migration towards f-Met-Leu-Phe, C5a, leukotriene B4, monocyte-derived chemotaxin/IL-8 and platelet-activating factor.	Hydrogen Peroxide	35-52	C-X-C motif chemokine ligand 8	Homo sapiens	189-193
2161489-2	1990	In the presence of NaF which is a selective inhibitor of 3"----5"-exonuclease center, AMP is an inhibitor of polymerization competitive with respect to dATP.	Adenosine Monophosphate	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
2105325-5	1990	Sodium fluoride (NaF), at concentrations known to activate guanine nucleotide regulatory proteins (G proteins), directly stimulated HUVEC PGI2 synthesis in a dose-dependent and time-dependent manner (20 mM NaF, 4.4 +/- 0.5-fold increase at 10 min, 11.9 +/- 1.5-fold increase at 30 min).	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
2105325-5	1990	Sodium fluoride (NaF), at concentrations known to activate guanine nucleotide regulatory proteins (G proteins), directly stimulated HUVEC PGI2 synthesis in a dose-dependent and time-dependent manner (20 mM NaF, 4.4 +/- 0.5-fold increase at 10 min, 11.9 +/- 1.5-fold increase at 30 min).	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	206-209
2105325-5	1990	Sodium fluoride (NaF), at concentrations known to activate guanine nucleotide regulatory proteins (G proteins), directly stimulated HUVEC PGI2 synthesis in a dose-dependent and time-dependent manner (20 mM NaF, 4.4 +/- 0.5-fold increase at 10 min, 11.9 +/- 1.5-fold increase at 30 min).	Epoprostenol	138-142	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
2170638-3	1990	Basal, forskolin, A1/NaF- and GppNHp-stimulated cyclic AMP synthesis in membranes from transformed cell lines was identical for schizophrenic and control subjects.	Cyclic AMP	48-58	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
2402188-1	1990	In isolated guinea pig gastric chief cells, sodium fluoride (NaF) stimulated a monophasic increase in diacylglycerol accumulation, while cholecystokinin (CCK) strongly stimulated its biphasic accumulation.	Sodium Fluoride	44-59	C-X-C motif chemokine ligand 8	Homo sapiens	61-64
2402188-1	1990	In isolated guinea pig gastric chief cells, sodium fluoride (NaF) stimulated a monophasic increase in diacylglycerol accumulation, while cholecystokinin (CCK) strongly stimulated its biphasic accumulation.	Diglycerides	102-116	C-X-C motif chemokine ligand 8	Homo sapiens	61-64
2402188-3	1990	Lanthanum chloride (La3+) effectively blocked NaF-stimulated increase in [Ca2+]i, but it blocked only CCK-stimulated late sustained phase of [Ca2+]i increase.	lanthanum chloride	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
2402188-3	1990	Lanthanum chloride (La3+) effectively blocked NaF-stimulated increase in [Ca2+]i, but it blocked only CCK-stimulated late sustained phase of [Ca2+]i increase.	lanthanum(3+)	20-24	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
2402188-4	1990	The effect of NaF on pepsinogen secretion was enhanced in the presence of 100 microM AlCl3.	Aluminum Chloride	85-90	C-X-C motif chemokine ligand 8	Homo sapiens	14-17
2402188-6	1990	These results suggest that NaF may activate a pertussis-toxin insensitive guanine nucleotide regulatory protein (G protein) coupled to a signal transducing mechanism which seems to be distinct from that activated by CCK, thereby inducing increases in diacylglycerol accumulation, Ca2+ influx and pepsinogen secretion in guinea pig gastric chief cells.	Diglycerides	251-265	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
1688564-9	1990	Further, dose-response studies showed that sodium fluoride (NaF), activator of G-binding proteins, and ouabain, inhibitor of Na+/H+ pump, increased levels of IL-6 mRNA.	Sodium Fluoride	43-58	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
2161489-2	1990	In the presence of NaF which is a selective inhibitor of 3"----5"-exonuclease center, AMP is an inhibitor of polymerization competitive with respect to dATP.	2'-deoxyadenosine triphosphate	152-156	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
33771440-6	2021	RESULTS: Both conventional hydrogels (etafilcon A, omafilcon A) and two of the four silicone hydrogels tested (balafilcon A, comfilcon A), exhibited some uptake of IL-1beta, IL-8 or TNF-alpha (p < 0.05).	Silicones	84-92	C-X-C motif chemokine ligand 8	Homo sapiens	174-178
33814546-8	2021	Aripiprazole was also associated with reduced concentrations of the inflammatory cytokines interleukin-8 and tumor necrosis factor (P < 0.01) during the first 8 weeks of treatment in medication-naive patients with FES.	Aripiprazole	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
33807391-0	2021	IL-8 as a Potential Therapeutic Target for Periodontitis and Its Inhibition by Caffeic Acid Phenethyl Ester In Vitro.	caffeic acid phenethyl ester	79-107	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
33807391-6	2021	IL-8 mRNA expression was analyzed in saliva-stimulated THP-1 cells treated with CAPE and the heme oxygenase-1 (HO-1) inhibitor tin-protoporphyrin (SnPP).	caffeic acid phenethyl ester	80-84	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
33807391-6	2021	IL-8 mRNA expression was analyzed in saliva-stimulated THP-1 cells treated with CAPE and the heme oxygenase-1 (HO-1) inhibitor tin-protoporphyrin (SnPP).	tin protoporphyrin IX	127-145	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
33807391-6	2021	IL-8 mRNA expression was analyzed in saliva-stimulated THP-1 cells treated with CAPE and the heme oxygenase-1 (HO-1) inhibitor tin-protoporphyrin (SnPP).	S-Nitroso-N-propionyl-D,L-penicillamine	147-151	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
33807391-10	2021	However, the IKK inhibitor BMS-345541, NF-kappaB inhibitor BAY 11-7082, and CAPE attenuated saliva-induced IL-8 expression.	3-(4-methylphenylsulfonyl)-2-propenenitrile	59-70	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
33807391-10	2021	However, the IKK inhibitor BMS-345541, NF-kappaB inhibitor BAY 11-7082, and CAPE attenuated saliva-induced IL-8 expression.	caffeic acid phenethyl ester	76-80	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
33807391-13	2021	The targeted suppression of IL-8 production using CAPE reduces inflammation and periodontitis.	caffeic acid phenethyl ester	50-54	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
33779714-8	2021	At the same time, fasudil led to the reduction of IL-1beta, TNF-alpha, IL-6 and IL-8 mRNA levels in insulin-treated cells.	fasudil	18-25	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
33777193-7	2021	Furthermore, miR-23 overexpression suppressed inflammation via reducing TNF-alpha, IL-1beta and IL-8 expression levels compared with the NC mimic group.	mir-23	13-19	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
33589388-1	2021	18F-fluorodeoxyglucose (18F-FDG) and 18F-sodium fluoride (18F-NaF) are front-runners in PET.	18f-sodium fluoride	37-56	C-X-C motif chemokine ligand 8	Homo sapiens	62-65
33589389-1	2021	PET imaging with 18F-sodium fluoride (NaF), combined with computed tomography or magnetic resonance, is a sensitive method of assessing bone turnover.	18f-sodium fluoride	17-36	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
33816157-1	2021	Background: The present study aimed to investigate the clinical implication of F-18 sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) for assessing the disease activity of rheumatoid arthritis.	f-18 sodium fluoride	79-99	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
33816157-11	2021	Conclusions: Summed joint uptake on F-18 NaF PET/CT had a strong positive correlation with DAS28-ESR and accurately predicted high disease activity.	das28-esr	91-100	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
33801712-10	2021	The acrylic resin containing 10 wt% NaF released a high amount of ions over a period of 1 week (1.58 microg/cm2), but the amount of released ions decreased rapidly after 14 days of storage.	Acrylic Resins	4-17	C-X-C motif chemokine ligand 8	Homo sapiens	36-39
33815104-4	2021	We showed that METH and HIV-Tat damaged the BBB in vitro, producing abnormal cell morphology, increased apoptosis, reduced protein expression of the tight junctions (TJ) including Junctional adhesion molecule A (JAMA) and Occludin, and a junctional associated protein Zonula occludens 1 (ZO1), and increased the flux of sodium fluorescein (NaF) across the hCMEC/D3 cells monolayer.	Methamphetamine	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	340-343
33767939-3	2021	The aim of this study was to investigate the therapeutic effects of the combination of erythropoietin and methylprednisolone in the treatment of ischemia-reperfusion injury to the spinal cord and to analyze its effects on the levels of interleukin-1 beta (IL-1beta), interleukin-1 receptor antagonist (IL-1RA), and interleukin-8 (IL-8).	Methylprednisolone	106-124	C-X-C motif chemokine ligand 8	Homo sapiens	315-328
33767939-3	2021	The aim of this study was to investigate the therapeutic effects of the combination of erythropoietin and methylprednisolone in the treatment of ischemia-reperfusion injury to the spinal cord and to analyze its effects on the levels of interleukin-1 beta (IL-1beta), interleukin-1 receptor antagonist (IL-1RA), and interleukin-8 (IL-8).	Methylprednisolone	106-124	C-X-C motif chemokine ligand 8	Homo sapiens	330-334
33816541-14	2021	The increase in IL-8 was significantly correlated with decreases in total cholesterol (R 2 = 0.24; P = 0.008), LDL-C (R 2 = 0.17; P = 0.031) and glucose (R 2 = 0.44; P = 0.0001).	Cholesterol	74-85	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
33816541-14	2021	The increase in IL-8 was significantly correlated with decreases in total cholesterol (R 2 = 0.24; P = 0.008), LDL-C (R 2 = 0.17; P = 0.031) and glucose (R 2 = 0.44; P = 0.0001).	ldl-c	111-116	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
33816541-14	2021	The increase in IL-8 was significantly correlated with decreases in total cholesterol (R 2 = 0.24; P = 0.008), LDL-C (R 2 = 0.17; P = 0.031) and glucose (R 2 = 0.44; P = 0.0001).	Glucose	145-152	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
33815104-9	2021	Further, 8-Br-ADPR attenuated the effects of METH and HIV-Tat on the BBB in tree shrews-namely, down-regulated TJ protein expression and increased BBB permeability to Evans blue (EB) and NaF.	8-br-adpr	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	187-190
33815104-6	2021	Pretreatment with n-acetylcysteine amide (NACA) alleviated the oxidative stress response and BBB damage characterized by improving cell morphology, viability, apoptosis levels, TJ protein expression levels, and NaF flux.	N-Acetylcysteinamide	18-40	C-X-C motif chemokine ligand 8	Homo sapiens	211-214
33815104-6	2021	Pretreatment with n-acetylcysteine amide (NACA) alleviated the oxidative stress response and BBB damage characterized by improving cell morphology, viability, apoptosis levels, TJ protein expression levels, and NaF flux.	N-Acetylcysteinamide	42-46	C-X-C motif chemokine ligand 8	Homo sapiens	211-214
33798967-9	2021	The results of the autopsy and laboratory tests in the present cases and those of cultured cell experiments indicated that CNS disorders caused by CNS stimulants such as amphetamines led to changes in IL-6 as an immune response, which suggests that IL-8 may help protect nerve cells in cases involving heat stroke and stimulants.	Amphetamines	170-182	C-X-C motif chemokine ligand 8	Homo sapiens	249-253
33767707-7	2021	Compared to that in control patients, the expression of interleukin (IL)-8 and TLR7 pathway molecules in B-cells was higher in patients with pSS-associated thrombocytopenia.	pss	141-144	C-X-C motif chemokine ligand 8	Homo sapiens	56-74
33778274-8	2021	Results: First, the reduced mitochondrial membrane potential (DeltaPsim) and secretion of proinflammatory factors (IL-1beta, IL-8, and MCP-1) induced by TNF-alpha were significantly reversed by treatment with Feprazone.	Feprazone	209-218	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
32796483-1	2020	OBJECTIVES: To evaluate the interobserver agreement and the diagnostic performance in F-sodium fluoride (F-NaF) PET/computed tomography (CT) for the detection of skull-base bone invasion (SBBI) and osseous metastases in patients with newly diagnosed nasopharyngeal carcinoma (NPC).	f-sodium fluoride	86-103	C-X-C motif chemokine ligand 8	Homo sapiens	107-110
33778827-10	2020	The results of ELLISA and Western blot showed that compared with the untreated group, the treatment groups inhibited the expression of inflammatory factors IL-6, IL-1beta and TNF-alpha, and promoted the expression of IL-8, and the effect of EDTA+HA group was much more significant(P<0.05).	Edetic Acid	241-245	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
33807929-5	2021	Losartan attenuated the AT-II-stimulated production of vascular endothelial growth factor-A (VEGF-A) and interleukin-8 and suppressed lenvatinib-mediated autocrine VEGF-A production in HCC cells.	Losartan	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	105-118
33379200-7	2020	Iron oxide increased IL-8 production while silica also induced significant production of IL-1beta.	ferric oxide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
33379200-8	2020	Both iron oxide and silica enhanced LPS-induced production of TNF-alpha, IL-1beta, IL-6 and IL-8 in THP-1 cells with most of these responses replicated in PBMCs.	ferric oxide	5-15	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
33379200-8	2020	Both iron oxide and silica enhanced LPS-induced production of TNF-alpha, IL-1beta, IL-6 and IL-8 in THP-1 cells with most of these responses replicated in PBMCs.	Silicon Dioxide	20-26	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
33237239-12	2020	An application of topical NaF varnishes was effective in reducing TSL and enamel roughness after erosion challenges, being the CCP-ACP/NaF varnish more effective than NaF varnish and water after 3 days of erosion.	ccp	127-130	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
33237239-12	2020	An application of topical NaF varnishes was effective in reducing TSL and enamel roughness after erosion challenges, being the CCP-ACP/NaF varnish more effective than NaF varnish and water after 3 days of erosion.	acp	131-134	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
33237239-12	2020	An application of topical NaF varnishes was effective in reducing TSL and enamel roughness after erosion challenges, being the CCP-ACP/NaF varnish more effective than NaF varnish and water after 3 days of erosion.	Water	183-188	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
33033709-7	2020	Notably, the mRNA level of interleukin-8 (IL-8)/CXCL8 was highly elevated in 15d-PGJ2-stimulated MCF-7 cells.	9-deoxy-delta-9-prostaglandin D2	81-85	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
33033709-7	2020	Notably, the mRNA level of interleukin-8 (IL-8)/CXCL8 was highly elevated in 15d-PGJ2-stimulated MCF-7 cells.	9-deoxy-delta-9-prostaglandin D2	81-85	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
33033709-7	2020	Notably, the mRNA level of interleukin-8 (IL-8)/CXCL8 was highly elevated in 15d-PGJ2-stimulated MCF-7 cells.	9-deoxy-delta-9-prostaglandin D2	81-85	C-X-C motif chemokine ligand 8	Homo sapiens	48-53
33033709-8	2020	15d-PGJ2-induced up-regulation of IL-8/CXCL8 expression was abrogated by silencing of Snail short interfering RNA.	15-deoxy-delta(12,14)-prostaglandin J2	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
33033709-8	2020	15d-PGJ2-induced up-regulation of IL-8/CXCL8 expression was abrogated by silencing of Snail short interfering RNA.	15-deoxy-delta(12,14)-prostaglandin J2	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	39-44
33033709-11	2020	Taken together, above findings suggest that 15d-PGJ2 induces EMT through up-regulation of Snail expression and subsequent production of CXCL8 as a putative activator of fibroblasts, which may contribute to tumor-stroma interaction in inflammatory breast cancer microenvironment.	9-deoxy-delta-9-prostaglandin D2	48-52	C-X-C motif chemokine ligand 8	Homo sapiens	136-141
33824247-3	2020	TCS markedly downregulated IL-6, IL-8, and IL-15 in human periodontal ligament fibroblasts (HPDLFs) treated with LPS-PG.	Triclosan	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
29261619-2	2018	Bone scintigraphy with [Tc]hydroxymethylene diphosphonate (Tc-HDP) and [F]sodium fluoride (F-NaF) have been investigated in the noninvasive diagnosis of transthyretin (ATTR)-related cardiac amyloidosis.	[f]sodium fluoride	71-89	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
32244040-7	2020	THC and CBD (both at 10 muM) attenuated TLR3/4-induced IRF3 activation and induction of CXCL10/IFN-beta, while both phytocannabinoids failed to impact TLR4-induced IkappaB-alpha degradation and TNF-alpha/CXCL8 expression.	Dronabinol	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	204-209
32244040-7	2020	THC and CBD (both at 10 muM) attenuated TLR3/4-induced IRF3 activation and induction of CXCL10/IFN-beta, while both phytocannabinoids failed to impact TLR4-induced IkappaB-alpha degradation and TNF-alpha/CXCL8 expression.	Cannabidiol	8-11	C-X-C motif chemokine ligand 8	Homo sapiens	204-209
29743070-3	2018	We have previously demonstrated that hydrogen sulfide (H2S) can inhibit ASM cell proliferation and CXCL8 release, from cells isolated from non-smokers.	Hydrogen Sulfide	37-53	C-X-C motif chemokine ligand 8	Homo sapiens	99-104
29743070-3	2018	We have previously demonstrated that hydrogen sulfide (H2S) can inhibit ASM cell proliferation and CXCL8 release, from cells isolated from non-smokers.	Hydrogen Sulfide	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	99-104
29743070-6	2018	Proliferation and cytokine release (IL-6 and CXCL8) of ASM was induced by FCS, and measured by bromodeoxyuridine incorporation and ELISA, respectively.	Bromodeoxyuridine	95-112	C-X-C motif chemokine ligand 8	Homo sapiens	45-50
26820827-6	2016	5-HT-induced elevation of IL-8 at both mRNA and protein levels was observed, which was inhibited by TEMPOL (a free radical scavenger), and inhibitors for p38 MAPK (SB203580) and ERK (U0126), in line with the time-dependent phosphorylation of p38 MAPK and ERK.	tempol	100-106	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
26246181-0	2016	Poly-L-Arginine Acts Synergistically with LPS to Promote the Release of IL-6 and IL-8 via p38/ERK Signaling Pathways in NCI-H292 Cells.	polyarginine	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
26246181-2	2016	The pharmacological function of MBP can be mimicked by poly-L-arginine (PLA), however, the potential signaling mechanisms of LPS-PLA-induced release of the inflammatory cytokines interleukin (IL)-6 and IL-8 remain unclear.	polyarginine	55-70	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
26295910-8	2015	Finally, the analysis of blood specimens stored with and without preservatives in both groups suggests that specimens stored with NaF/KOx maintain mephedrone stability better than those stored with EDTA (p&lt;0.001) and those stored without preservatives (p&lt;0.0001), therefore, we strongly recommend in order to maintain the highest mephedrone stability in blood, to store specimens at -20 C adding NaF/KOx as preservative.	mephedrone	147-157	C-X-C motif chemokine ligand 8	Homo sapiens	130-133
25589619-6	2015	Dabrafenib and trametinib in BRAF V600E/K, and trametinib in BRAF wild-type tumor cells induced apoptosis markers, upregulated HLA molecule expression, and downregulated certain immunosuppressive factors such as PD-L1, IL1, IL8, NT5E, and VEGFA.	trametinib	47-57	C-X-C motif chemokine ligand 8	Homo sapiens	224-227
24099766-0	2013	NOD2 triggers PGE2 synthesis leading to IL-8 activation in Staphylococcus aureus-infected human conjunctival epithelial cells.	Dinoprostone	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
24099766-2	2013	As in some cell types both the bacteria may induce the release of prostaglandin E2 (PGE2) and PGE2 may affect the expression of IL-8, we aimed at investigating whether in human conjunctival cells infected with S. aureus or P. aeruginosa the activation of IL-8 transcription was mediated by PGE2 and which were the underlying molecular mechanisms.	Dinoprostone	94-98	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
24099766-2	2013	As in some cell types both the bacteria may induce the release of prostaglandin E2 (PGE2) and PGE2 may affect the expression of IL-8, we aimed at investigating whether in human conjunctival cells infected with S. aureus or P. aeruginosa the activation of IL-8 transcription was mediated by PGE2 and which were the underlying molecular mechanisms.	Dinoprostone	94-98	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
24099766-3	2013	We found that S. aureus, but not P. aeruginosa, triggered IL-8 activation by increasing COX-2 expression and PGE2 levels in a time-dependent manner.	Dinoprostone	109-113	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
23861935-7	2013	Stimulation with the corresponding agonists Pam3CSK4, poly(I:C), LPS, R-837 and iE-DAP, respectively, induced IL-6, IL-8 and GM-CSF release and up-regulation of ICAM-1 and HLA-DR, while poly(I:C) also affected the release of eotaxin and RANTES.	alpha,beta-diacryloxypropionic acid	83-86	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
27667548-5	2016	Furthermore, baicalein blocked the TNF-alpha-induced expression of NF-kappaB target genes involved in anti-apoptosis (cIAP-1, cIAP-2, FLIP and BCL-2), proliferation (COX-2, cyclin D1 and c-Myc), invasion (MMP-9), angiogenesis (VEGF) and major inflammatory cytokines (IL-8 and MCP1).	baicalein	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	267-271
25589619-6	2015	Dabrafenib and trametinib in BRAF V600E/K, and trametinib in BRAF wild-type tumor cells induced apoptosis markers, upregulated HLA molecule expression, and downregulated certain immunosuppressive factors such as PD-L1, IL1, IL8, NT5E, and VEGFA.	dabrafenib	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	224-227
26820827-6	2016	5-HT-induced elevation of IL-8 at both mRNA and protein levels was observed, which was inhibited by TEMPOL (a free radical scavenger), and inhibitors for p38 MAPK (SB203580) and ERK (U0126), in line with the time-dependent phosphorylation of p38 MAPK and ERK.	SB 203580	164-172	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
20218345-8	2010	CONCLUSION: LX inhibits TLR-mediated production of both proinflammatory (IL-1, IL-6, IL-8, IL-12, TNFalpha) and anti-inflammatory (IL-10) cytokinesby PBMC of healthy subjects in vitro.	lx	12-14	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
26820827-6	2016	5-HT-induced elevation of IL-8 at both mRNA and protein levels was observed, which was inhibited by TEMPOL (a free radical scavenger), and inhibitors for p38 MAPK (SB203580) and ERK (U0126), in line with the time-dependent phosphorylation of p38 MAPK and ERK.	U 0126	183-188	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
9860036-8	1998	Within-treatment comparisons suggested that mometasone furoate reduced the antigen-induced late-phase response for IL-6, IL-8, and eosinophils compared with pretreatment.	Mometasone Furoate	44-62	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
19180502-10	2009	After up-regulation of NOD-2 by TLR ligands, its ligand muramyl dipeptide (MDP) increased the expression of IL-6 and IL-8 via p38 and NF-kappaB.	Acetylmuramyl-Alanyl-Isoglutamine	56-73	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
19180502-10	2009	After up-regulation of NOD-2 by TLR ligands, its ligand muramyl dipeptide (MDP) increased the expression of IL-6 and IL-8 via p38 and NF-kappaB.	Acetylmuramyl-Alanyl-Isoglutamine	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
9269788-7	1997	Compared with vehicle control, pretreatment with SDZ MRL 953 markedly reduced the release of TNF-alpha, IL-1beta, IL-8, IL-6, and G-CSF, but augmented the increase in granulocyte counts to endotoxin.	Sulfadiazine	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
16946614-0	2006	The protective effect of TiF4, SnF2 and NaF on erosion of enamel by hydrochloric acid in vitro measured by white light interferometry.	Hydrochloric Acid	68-85	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
14561211-13	2002	It has been shown that macrolides inhibit the production of IL-8 and IL-1beta and the expression of ICAM-1, suggesting that macrolides block the aforementioned dual positive feedback system of neutrophil recruitment and thereby exert their clinical efficacy in the treatment of chronic sinusitis.	Macrolides	23-33	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
14561211-13	2002	It has been shown that macrolides inhibit the production of IL-8 and IL-1beta and the expression of ICAM-1, suggesting that macrolides block the aforementioned dual positive feedback system of neutrophil recruitment and thereby exert their clinical efficacy in the treatment of chronic sinusitis.	Macrolides	124-134	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
8584542-5	1995	When compared to air-exposed cells, NO2 induced increases in IL-6 (23.4-fold) and IL-8 (30.9-fold) mRNA abundance.	Nitrogen Dioxide	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
9860036-11	1998	CONCLUSION: These results suggest that the clinical activity of mometasone furoate nasal spray in seasonal allergic rhinitis is likely due, in part, to a reduction in the levels of histamine in nasal secretions related to the early phase response, and reductions in IL-6, IL-8, and eosinophils during the late phase response.	Mometasone Furoate	64-82	C-X-C motif chemokine ligand 8	Homo sapiens	272-276
8584542-6	1995	The NO2-dependent increases in mRNA expression reached a maximum between 0 and 1 h post exposure and returned to baseline levels within 24 h. IL-6 and IL-8 proteins as measured by enzyme-linked immunosorbent assays (ELISA) were also elevated in supernatants recovered from NO2-exposed BEAS-2B cells.	Nitrogen Dioxide	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
9860036-11	1998	CONCLUSION: These results suggest that the clinical activity of mometasone furoate nasal spray in seasonal allergic rhinitis is likely due, in part, to a reduction in the levels of histamine in nasal secretions related to the early phase response, and reductions in IL-6, IL-8, and eosinophils during the late phase response.	Histamine	181-190	C-X-C motif chemokine ligand 8	Homo sapiens	272-276
34289309-11	2022	Furthermore, CD142 silencing-induced IL-8 degradation was recovered by treatment of autophagy inhibitor 3-MA.	3-methyladenine	104-108	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
34609586-10	2022	In the exposed group a positive correlation between serum copper, arsenic and serum ICAM and IL8 was found.	Copper	58-64	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
34609586-10	2022	In the exposed group a positive correlation between serum copper, arsenic and serum ICAM and IL8 was found.	Arsenic	66-73	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
34609586-13	2022	CONCLUSION: Occupational exposure to copper and arsenic was associated with ventilatory and radiological impairment, with a corresponding increase in the serum level of ICAM-1 and IL8, which can be used as biomarkers for pulmonary impairment among copper smelter workers.	Copper	37-43	C-X-C motif chemokine ligand 8	Homo sapiens	180-183
34609586-13	2022	CONCLUSION: Occupational exposure to copper and arsenic was associated with ventilatory and radiological impairment, with a corresponding increase in the serum level of ICAM-1 and IL8, which can be used as biomarkers for pulmonary impairment among copper smelter workers.	Arsenic	48-55	C-X-C motif chemokine ligand 8	Homo sapiens	180-183
34609586-13	2022	CONCLUSION: Occupational exposure to copper and arsenic was associated with ventilatory and radiological impairment, with a corresponding increase in the serum level of ICAM-1 and IL8, which can be used as biomarkers for pulmonary impairment among copper smelter workers.	Copper	248-254	C-X-C motif chemokine ligand 8	Homo sapiens	180-183
34844316-7	2022	Inflammatory response analysis revealed BCB combustion aerosols to cause a mild increase in CXCL1 and CXCL8 levels, but in the case of SPR combustion aerosol, a decrease compared to control was observed.	Bromocholine bromide	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	102-107
34890707-0	2022	Nicotine stimulates IL-8 expression via ROS/NF-kappaB and ROS/MAPK/AP-1 axis in human gastric cancer cells.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
34890707-3	2022	The role of nicotine in IL-8 expression and the underlying mechanism is currently unknown.	Nicotine	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
34890707-4	2022	Here, we examined the effects of nicotine on IL-8 expression and explored the potential mechanisms in gastric cancer cells.	Nicotine	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
34890707-5	2022	We found that nicotine increases IL-8 expression.	Nicotine	14-22	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
34890707-9	2022	AGS gastric cancer cells pretreated with nicotine stimulate angiogenesis in the tumor microenvironment, partially abrogated by silencing IL-8 in AGS cells.	Nicotine	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
34890707-10	2022	In this study, we found that nicotine induces IL-8 expression via ROS/NF-kappaB and ROS/MAPK (Erk1/2, p38)/AP-1 axis in gastric cancer cells, thus stimulating endothelial cell proliferation and angiogenesis in the tumor microenvironment.	Nicotine	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
34800781-0	2022	The modulating effect of methoxy-derivatives of 2"-hydroxychalcones on the release of IL-8, MIF, VCAM-1 and ICAM-1 by colon cancer cells.	2'-hydroxychalcone	48-67	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
34971958-10	2022	The p38 inhibitor SB203580 inhibited the secretion of IL-8, slightly inhibited the secretion of IL-6, and did not affect NF-kappaB activity.	SB 203580	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
34781073-2	2022	DESIGN: Ameloblast-like cells (LS8 cells) were exposed to various concentrations of sodium fluoride (NaF) for up to 48 h. Runx2 expression was downregulated by gene silencing, and Foxo1 expression was up- and downregulated by gene overexpression and silencing, respectively.	Sodium Fluoride	84-99	C-X-C motif chemokine ligand 8	Homo sapiens	101-104
34781073-10	2022	CONCLUSION: The results indicated that NaF reduces Runx2 expression in LS8 cells and that decreased Foxo1/Runx2 expression induced by high fluoride is a cause of low KLK4 expression.	Fluorides	139-147	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
34236247-9	2022	17,18-EpETE significantly inhibited tumor necrosis factor (TNF)-alpha-induced production of interleukin (IL)-6 , IL-8, and mucin from cultured human airway epithelial cells dose dependently, and these antiinflammatory effects on cytokine production were abolished by GW1100, a selective GPR40 antagonist.	17,18-epoxy-5,8,11,14-eicosatetraenoic acid	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
34236247-9	2022	17,18-EpETE significantly inhibited tumor necrosis factor (TNF)-alpha-induced production of interleukin (IL)-6 , IL-8, and mucin from cultured human airway epithelial cells dose dependently, and these antiinflammatory effects on cytokine production were abolished by GW1100, a selective GPR40 antagonist.	GW1100	267-273	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
34593533-2	2022	METHODS: We performed 18F-sodium fluoride (18F-NaF) positron emission tomography/CT in patients with mild to moderate AS (peak aortic jet velocity between 2 and 4 m/s) and high versus low Lp(a) (>50 mg/dL vs <50 mg/dL, respectively).	18f-sodium fluoride	22-41	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
34593533-10	2022	Linear regression analysis showed valvular calcium score to be the only significant determinant of valvular 18F-NaF uptake (beta=0.63; 95% CI 0.38 to 0.88 per 1000 Agatston unit increase, p<0.001).	Calcium	43-50	C-X-C motif chemokine ligand 8	Homo sapiens	112-115
34763226-3	2022	At present, the objective of this study was to investigate the relationship between down-regulation of IKBKG gene expression and hepatocyte senescence induced by sodium fluoride (NaF).	Sodium Fluoride	162-177	C-X-C motif chemokine ligand 8	Homo sapiens	179-182
34614305-11	2022	RESULTS: Imiquimod significantly inhibited the activity of tyrosinase activity and decreased melanin content in melanocytes and significantly increased apoptosis and IL-6, IL-8, and sICAM-1 production in melanocytes.	Imiquimod	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
34170488-4	2022	We aimed to study the effect of RGZ onto inflammation-induced secretion of CXCL10, IFNgamma, TNFalpha, interleukin (IL)-6 and IL-8 by human CD4 + T and DCs, and onto IFNgamma/TNFalpha-dependent signaling in human cardiomyocytes associated with chemokine release.	Rosiglitazone	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
34170488-8	2022	In human cardiomyocytes, RGZ impaired IFNgamma/TNFalpha signal transduction, blocking the phosphorylation/nuclear translocation of signal transducer and activator of transcription 1 (Stat1) and nuclear factor-kB (NF-kB), in association with a significant decrease in CXCL10 expression, IL-6 and IL-8 release.	Rosiglitazone	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	295-299
34755269-11	2022	After colchicine treatment, patients had higher BUN and lower serum levels of IL-8, IL-12p70, and IL-17A.	Colchicine	6-16	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
34651203-15	2022	HIF-1 activation increased IL-1beta and IL-8 in human uroepithelial cells treated with high glucose concentration.	Glucose	92-99	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
34763226-7	2022	RESULTS: The number of senescence-positive cells in rat liver tissues was increased as well as the level of IL-8 and the expression levels of p16, p21 and IKBKG in fluoride exposure to rat depending on the fluoride concentration.	Fluorides	164-172	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
34763226-7	2022	RESULTS: The number of senescence-positive cells in rat liver tissues was increased as well as the level of IL-8 and the expression levels of p16, p21 and IKBKG in fluoride exposure to rat depending on the fluoride concentration.	Fluorides	206-214	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
34838662-8	2022	Long time to return of spontaneous circulation and high lactate level at admission were associated with increased complement activation (TCC and C3bc), pro-inflammatory cytokines (IL-6, IL-8) and endothelial injury (syndecan-1) at admission.	Lactic Acid	56-63	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
34883095-6	2022	Moreover, exposure to DPAA at 50 microM for 96 h or 10 microM for 288 h in NHA induced hypersecretion of cytokines induced in DPAA-exposed NRA (MCP-1, adrenomedullin, FGF-2, CXCL1, and IL-6), and IL-8 besides into culture medium.	diphenylarsinic acid	22-26	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
34883095-6	2022	Moreover, exposure to DPAA at 50 microM for 96 h or 10 microM for 288 h in NHA induced hypersecretion of cytokines induced in DPAA-exposed NRA (MCP-1, adrenomedullin, FGF-2, CXCL1, and IL-6), and IL-8 besides into culture medium.	nha	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
34930349-1	2021	BACKGROUND: To investigate the role of adenosine monophosphate (AMP)-activated protein kinase (AMPK) on the production of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, prostaglandin E2 and F2alpha induced by IL-1beta in endometrial stromal cells (ESCs) following treatment with 5-aminoimidazole-4- carboxamide ribonucleoside (AICAR).	5-aminoimidazole-4- carboxamide ribonucleoside	294-340	C-X-C motif chemokine ligand 8	Homo sapiens	122-140
34936813-8	2022	mTOR inhibitor rapamycin significantly suppressed the elevation of IL-6, IL-8, and VEGF stimulated by 7-KC.	Sirolimus	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
34936813-10	2022	Conclusions: Inhibition of mTOR signaling pathway suppressed the elevation of inflammatory cytokines IL-6, IL-8, and the angiogenic agent VEGF induced by 7-KC.	7-ketocholesterol	154-158	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
34930349-1	2021	BACKGROUND: To investigate the role of adenosine monophosphate (AMP)-activated protein kinase (AMPK) on the production of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, prostaglandin E2 and F2alpha induced by IL-1beta in endometrial stromal cells (ESCs) following treatment with 5-aminoimidazole-4- carboxamide ribonucleoside (AICAR).	Adenosine	39-48	C-X-C motif chemokine ligand 8	Homo sapiens	122-140
34930349-1	2021	BACKGROUND: To investigate the role of adenosine monophosphate (AMP)-activated protein kinase (AMPK) on the production of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, prostaglandin E2 and F2alpha induced by IL-1beta in endometrial stromal cells (ESCs) following treatment with 5-aminoimidazole-4- carboxamide ribonucleoside (AICAR).	Adenosine Monophosphate	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	122-140
34941893-5	2021	Additionally, high concentrations of capsaicin (0.02-2 mM) damage enterocytes (Caco-2 and HT-29) as indicated by cell viability test, supernatant cytokine (IL-8), transepithelial electrical resistance (TEER) and transepithelial FITC-dextran (4.4 kDa) but were attenuated by Lactobacillus condition media (LCM) from both probiotic-strains.	Capsaicin	37-46	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
34930349-1	2021	BACKGROUND: To investigate the role of adenosine monophosphate (AMP)-activated protein kinase (AMPK) on the production of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, prostaglandin E2 and F2alpha induced by IL-1beta in endometrial stromal cells (ESCs) following treatment with 5-aminoimidazole-4- carboxamide ribonucleoside (AICAR).	acadesine	342-347	C-X-C motif chemokine ligand 8	Homo sapiens	122-140
34930349-3	2021	We examined the effects of IL-1beta, IL-1 ra and AICAR on the production of IL-8, MCP-1, PGE2 and PGF2alpha in human ESCs.	Radium	42-44	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
34930349-3	2021	We examined the effects of IL-1beta, IL-1 ra and AICAR on the production of IL-8, MCP-1, PGE2 and PGF2alpha in human ESCs.	acadesine	49-54	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
34977169-8	2021	Results: AEDPPE significantly promoted the migration and invasion of HTR-8/SVneo cells, and it decreased the expression of interleukins 1 beta (IL-1beta), interleukin 6 (IL-6), and interleukin 8 (IL-8).	aedppe	9-15	C-X-C motif chemokine ligand 8	Homo sapiens	181-194
34977169-8	2021	Results: AEDPPE significantly promoted the migration and invasion of HTR-8/SVneo cells, and it decreased the expression of interleukins 1 beta (IL-1beta), interleukin 6 (IL-6), and interleukin 8 (IL-8).	aedppe	9-15	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
34975472-0	2021	UDCA Inhibits Hypoxic Hepatocellular Carcinoma Cell-Induced Angiogenesis Through Suppressing HIF-1alpha/VEGF/IL-8 Intercellular Signaling.	Ursodeoxycholic Acid	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
34918964-8	2021	Results: Our findings showed that inhalation of CBD was able to not only limit the tumor growth but also to alter the dynamics of TME by repressing P-selectin, apelin, and interleukin (IL)-8, as well as blocking a key immune checkpoint-indoleamine 2,3-dioxygenase (IDO).	Cannabidiol	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	172-190
34943253-8	2021	Exposure to low doses of CAP enhanced the proliferation rate of cells and stimulated the expression of key genes (KGF, MMP2, GMCSF, IL-6, and IL-8) in fibroblasts, indicating the activation and initiation of the skin repair process.	cap	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
34975472-7	2021	In HCC cells, UDCA inhibited hypoxia-induced upregulation of VEGF and IL-8 both in mRNA and protein levels.	Ursodeoxycholic Acid	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
34975889-0	2021	Antcin K Inhibits TNF-alpha, IL-1beta and IL-8 Expression in Synovial Fibroblasts and Ameliorates Cartilage Degradation: Implications for the Treatment of Rheumatoid Arthritis.	antcin K	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
34975472-8	2021	UDCA also inhibited IL-8-induced angiogenesis in vitro and in vivo through suppressing IL-8-induced phosphorylation of ERK.	Ursodeoxycholic Acid	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
34975889-3	2021	In our analysis of the mechanism of action, Antcin K inhibited the expression of three cytokines (tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta) and IL-8) in human RASFs; cytokines that are crucial to RA synovial inflammation.	antcin K	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
34975472-8	2021	UDCA also inhibited IL-8-induced angiogenesis in vitro and in vivo through suppressing IL-8-induced phosphorylation of ERK.	Ursodeoxycholic Acid	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
34975889-6	2021	The inhibitory effects of Antcin K upon TNF-alpha, IL-1beta and IL-8 expression in human RASFs was achieved through the downregulation of the FAK, PI3K, AKT and NF-kappaB signaling cascades.	antcin K	26-34	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
34975472-12	2021	Transfection of the HIF-1alpha overexpression plasmid reversed the effects of UDCA on hypoxic HCC cell-induced angiogenesis, HRE activity, and expressions of IL-8 and VEGF.	Ursodeoxycholic Acid	78-82	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
34975472-13	2021	Conclusions: Our results demonstrated that UDCA could inhibit hypoxic HCC cell-induced angiogenesis through suppressing HIF-1alpha/VEGF/IL-8-mediated intercellular signaling between HCC cells and endothelial cells.	Ursodeoxycholic Acid	43-47	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
34915624-14	2021	In addition, MSC may improve the steroid resistance by reducing the expression of IL-8.	Steroids	33-40	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
34944509-11	2021	High doses of vitamin D supplementation led to a significant decrease in pro-inflammatory cytokines (IFN- , TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17) and high-sensitivity C-reactive protein (hsCRP), whereas the production of anti-inflammatory cytokines (IL-10, IL-5) was up-regulated.	Vitamin D	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
34886812-12	2021	Simultaneously, acacetin reduced mesothelial cell-induced transcripts and production of pro-inflammatory cytokine IL-6 and IL-8 in ovarian cancer cells.	acacetin	16-24	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
34943075-12	2021	Our results revealed that administration of Rg3 diminished the production of interleukin 8 (IL-8) and matrix metallopeptidase 9 (MMP-9) in chondrocytes via SIRT1/PGC-1alpha/SIRT3/p38 MAPK/NF-kappaB signaling in response to TNF-alpha stimulation.	ginsenoside Rg3	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	77-90
34943075-12	2021	Our results revealed that administration of Rg3 diminished the production of interleukin 8 (IL-8) and matrix metallopeptidase 9 (MMP-9) in chondrocytes via SIRT1/PGC-1alpha/SIRT3/p38 MAPK/NF-kappaB signaling in response to TNF-alpha stimulation.	ginsenoside Rg3	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
34888674-9	2022	Also, NAA/Cr ratio was positively correlated with circulating IL-8 levels (rho = 0.26, P = 0.04).	N-acetylaspartate	6-9	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
34888674-9	2022	Also, NAA/Cr ratio was positively correlated with circulating IL-8 levels (rho = 0.26, P = 0.04).	Chromium	10-12	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
34959964-6	2021	RESULTS: Vivomixx  supplementation induced a better response to PCV13 immunization, as shown by greater change in anti-Pn CPS13 IgG and increase in salivary IgA, IL-10 and IL-8.	vivomixx	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
34957146-8	2021	The levels of IL-8 and TNF-alpha were positively correlated with OSDI scores (p = 0.046, p = 0.043, respectively) and negatively correlated with f-NIKBUT and FBUT (p = 0.026, p = 0.006, respectively).	fbut	158-162	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
34950134-8	2021	Imiquimod also reduced poly(I:C)-induced pro-inflammatory cytokines including IL-1beta, IL-6, IL-8, and IL-33.	Imiquimod	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
34956864-6	2021	Results: In pre-treatment biopsies, TREM1 and known TREM-1 inducible cytokines (IL1B, IL8) were discovered by a statistical ranking procedure as top genes for which high expression was associated with reduced response to NAC, but only in the context of immunologically "hot" tumors otherwise associated with a high NAC response rate.	nac	221-224	C-X-C motif chemokine ligand 8	Homo sapiens	86-89
34943719-6	2021	Herein, we demonstrated that dexamethasone binds with high affinity to interlukin-1 (IL-1), IL-6, IL-8, IL-12, IL-21, INF2, TGFbeta-1, INF-gamma, CXCL8, some of the receptors, IL-1R, IL-21R, IFNGR, INFAR, IL-6alphaR-gp130, ST2 and the SARS-CoV-2 protein NSP macro X, and 3CLpro, forming stable drug-protein complexes.	Dexamethasone	29-42	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
34943719-6	2021	Herein, we demonstrated that dexamethasone binds with high affinity to interlukin-1 (IL-1), IL-6, IL-8, IL-12, IL-21, INF2, TGFbeta-1, INF-gamma, CXCL8, some of the receptors, IL-1R, IL-21R, IFNGR, INFAR, IL-6alphaR-gp130, ST2 and the SARS-CoV-2 protein NSP macro X, and 3CLpro, forming stable drug-protein complexes.	Dexamethasone	29-42	C-X-C motif chemokine ligand 8	Homo sapiens	146-151
34950134-8	2021	Imiquimod also reduced poly(I:C)-induced pro-inflammatory cytokines including IL-1beta, IL-6, IL-8, and IL-33.	Poly I-C	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
34878076-1	2021	This randomized three-armed controlled clinical trial compared the effect of titanium tetrafluoride (TiF4) and sodium fluoride (NaF) varnishes on caries control in smooth surfaces of permanent dentition and children"s acceptability.	Sodium Fluoride	111-126	C-X-C motif chemokine ligand 8	Homo sapiens	128-131
34941711-0	2021	Indoxyl Sulfate Elevated Lnc-SLC15A1-1 Upregulating CXCL10/CXCL8 Expression in High-Glucose Endothelial Cells by Sponging MicroRNAs.	Indican	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	59-64
34688024-1	2021	The positron emitters (18F-Sodium Fluoride (NaF)) and X-rays used in Positron emission tomography (PET) combined with computed tomography (PET/CT) imaging have a high radiation dose, which results in a high patient dose.	18f-sodium fluoride	23-42	C-X-C motif chemokine ligand 8	Homo sapiens	44-47
34941711-7	2021	We discovered that lnc-SLC15A1-1 expression was significantly increased upon IS treatment in comparison with high glucose alone, and then cascaded the signal of chemokines CXCL10 and CXCL8 via sponging miR-27b, miR-297, and miR-150b.	Glucose	114-121	C-X-C motif chemokine ligand 8	Homo sapiens	183-188
34175752-2	2021	The LiCl, NaOH, and NaF salts are used as the source of Li+ and Na+ ions in the LDI of the dipeptides.	Dipeptides	91-101	C-X-C motif chemokine ligand 8	Homo sapiens	20-23
34175752-4	2021	The characteristic peak, related to (dipeptide-H + 2Na)+ species, is observed in the mass spectrum of Phe-Ala and Tyr-Ala dipeptides in the presence of NaF, while the breaking of the peptide bond (OC-NH) occurs for the Phe-Phe in the presence of the aforementioned salts.	Dipeptides	37-46	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
34175752-4	2021	The characteristic peak, related to (dipeptide-H + 2Na)+ species, is observed in the mass spectrum of Phe-Ala and Tyr-Ala dipeptides in the presence of NaF, while the breaking of the peptide bond (OC-NH) occurs for the Phe-Phe in the presence of the aforementioned salts.	2-NAPHTHALENEMETHANOL	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
34175752-4	2021	The characteristic peak, related to (dipeptide-H + 2Na)+ species, is observed in the mass spectrum of Phe-Ala and Tyr-Ala dipeptides in the presence of NaF, while the breaking of the peptide bond (OC-NH) occurs for the Phe-Phe in the presence of the aforementioned salts.	Phenylalanine	102-105	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
34175752-4	2021	The characteristic peak, related to (dipeptide-H + 2Na)+ species, is observed in the mass spectrum of Phe-Ala and Tyr-Ala dipeptides in the presence of NaF, while the breaking of the peptide bond (OC-NH) occurs for the Phe-Phe in the presence of the aforementioned salts.	Alanine	106-109	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
34175752-4	2021	The characteristic peak, related to (dipeptide-H + 2Na)+ species, is observed in the mass spectrum of Phe-Ala and Tyr-Ala dipeptides in the presence of NaF, while the breaking of the peptide bond (OC-NH) occurs for the Phe-Phe in the presence of the aforementioned salts.	Tyr-Ala	114-121	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
34175752-4	2021	The characteristic peak, related to (dipeptide-H + 2Na)+ species, is observed in the mass spectrum of Phe-Ala and Tyr-Ala dipeptides in the presence of NaF, while the breaking of the peptide bond (OC-NH) occurs for the Phe-Phe in the presence of the aforementioned salts.	Dipeptides	122-132	C-X-C motif chemokine ligand 8	Homo sapiens	152-155
34175752-6	2021	The mass spectra of the dipeptides, recorded in the presence of LiCl, are crowded compared to those recorded in the presence of NaF and NaOH showing the effect of the type of alkali salt on the dipeptide fragmentation.	Dipeptides	194-203	C-X-C motif chemokine ligand 8	Homo sapiens	128-131
34885572-2	2021	The electrical conductivity of molten cryolite mixtures NaF-AlF3-CaF2-Al2O3 with cryolite ratio (CR) of 2.1-3.0 and content of CaF2 and Al2O3, up to 8 wt%, was measured at the temperatures from liquidus to 1300 K. Based on the experimental results, a multifunctional equation for the electrical conductivity of oxide-fluoride cryolite melts was evaluated.	aluminum fluoride	60-64	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
34885572-2	2021	The electrical conductivity of molten cryolite mixtures NaF-AlF3-CaF2-Al2O3 with cryolite ratio (CR) of 2.1-3.0 and content of CaF2 and Al2O3, up to 8 wt%, was measured at the temperatures from liquidus to 1300 K. Based on the experimental results, a multifunctional equation for the electrical conductivity of oxide-fluoride cryolite melts was evaluated.	Oxides	311-316	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
34885572-2	2021	The electrical conductivity of molten cryolite mixtures NaF-AlF3-CaF2-Al2O3 with cryolite ratio (CR) of 2.1-3.0 and content of CaF2 and Al2O3, up to 8 wt%, was measured at the temperatures from liquidus to 1300 K. Based on the experimental results, a multifunctional equation for the electrical conductivity of oxide-fluoride cryolite melts was evaluated.	Fluorides	317-325	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
34885572-5	2021	The activation energy of electrical conductivity for molten NaF-AlF3 mixtures with CR 3.0 and 2.1, determined by the most mobile cations Na+, increased from 15.8 kJ/mol up to 18.5 kJ/mol.	aluminum fluoride	64-68	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
34885572-5	2021	The activation energy of electrical conductivity for molten NaF-AlF3 mixtures with CR 3.0 and 2.1, determined by the most mobile cations Na+, increased from 15.8 kJ/mol up to 18.5 kJ/mol.	Chromium	83-85	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
34885572-7	2021	Based on the ratio of the activation energies of the electrical conductivity and the viscous flow, the correlation between the electrical conductivity and viscosity of molten cryolite mixtures NaF-AlF3-CaF2-Al2O3 was illustrated.	cryolite	175-183	C-X-C motif chemokine ligand 8	Homo sapiens	193-196
34876290-8	2022	Interleukin-8 was upregulated after leptin and dimethyl itaconate treatment at 6 hours (FC 26.35 at D4, P <= .001, and FC 23.26 at D3, P = .006).	dimethyl itaconate	47-65	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
34180760-15	2021	This study provides a theoretical basis for elucidating the mechanism of mepivacaine-induced nerve cell damage, and overexpressed miR-183-5p likely become a novel strategy to combat mepivacaine-induced nerve damage.Abbreviations:miRNA: Micro RNA; PDCD4: Programmed Cell Death 4; MDA: Malondialdehyde; SOD: Superoxide Dismutase; ROS: Reactive Oxygen Species; WT: Wild Type; Mut: Mutant; UTR: Untranslated Region; IL-6: Interleukin-6; IL-1beta: Interleukin-1beta; TNF-alpha: Tumor Necrosis Factor-alpha; IL-8: Interleukin-8; COX-2: Cyclooxygenase-2; iNOS: inducible NOS; MEP: Mepivacaine.	mir-183-5p	130-140	C-X-C motif chemokine ligand 8	Homo sapiens	502-506
34560176-10	2021	Also, our results strongly suggested that BF4 also inhibits the endogenous cellular PC1/3 activity in Caco-2 cells, since PC1/3 inhibition by BF4 causes a large increase in IL-8 and IL-1beta secretion in Caco-2 cells.	fluoroboric acid	142-145	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
34560176-10	2021	Also, our results strongly suggested that BF4 also inhibits the endogenous cellular PC1/3 activity in Caco-2 cells, since PC1/3 inhibition by BF4 causes a large increase in IL-8 and IL-1beta secretion in Caco-2 cells.	fluoroboric acid	42-45	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
34180760-15	2021	This study provides a theoretical basis for elucidating the mechanism of mepivacaine-induced nerve cell damage, and overexpressed miR-183-5p likely become a novel strategy to combat mepivacaine-induced nerve damage.Abbreviations:miRNA: Micro RNA; PDCD4: Programmed Cell Death 4; MDA: Malondialdehyde; SOD: Superoxide Dismutase; ROS: Reactive Oxygen Species; WT: Wild Type; Mut: Mutant; UTR: Untranslated Region; IL-6: Interleukin-6; IL-1beta: Interleukin-1beta; TNF-alpha: Tumor Necrosis Factor-alpha; IL-8: Interleukin-8; COX-2: Cyclooxygenase-2; iNOS: inducible NOS; MEP: Mepivacaine.	mir-183-5p	130-140	C-X-C motif chemokine ligand 8	Homo sapiens	508-521
34506261-8	2021	Argon increased the proliferation of cardiomyocytes induced by OGD, decreased the release of LDH in cell culture medium, increased miR-21 expression in cells, decreased the expression of miR-21 target proteins PDCD4 and PTEN, decreased the levels of inflammatory factors (interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interleukin-8 (IL-8)) and oxidative stress factors (ROS and MDA), increased the SOD content, and decreased the cell apoptosis rate.	Argon	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	328-341
34402375-6	2021	Firstly, we found that Tamsulosin reduced high glucose-induced expressions of TNF-alpha, IL-6, and IL-8.	Tamsulosin	23-33	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
34402375-6	2021	Firstly, we found that Tamsulosin reduced high glucose-induced expressions of TNF-alpha, IL-6, and IL-8.	Glucose	47-54	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
34308769-8	2021	At the same time, sulforaphane weakened the ability of LPS to induce production of inflammatory cytokines (IL-1beta, IL-6, IL-8 and TNF-alpha) and the pro-apoptotic caspases-3 and -9.	sulforaphane	18-30	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
34506261-8	2021	Argon increased the proliferation of cardiomyocytes induced by OGD, decreased the release of LDH in cell culture medium, increased miR-21 expression in cells, decreased the expression of miR-21 target proteins PDCD4 and PTEN, decreased the levels of inflammatory factors (interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interleukin-8 (IL-8)) and oxidative stress factors (ROS and MDA), increased the SOD content, and decreased the cell apoptosis rate.	Argon	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	343-347
34847866-0	2021	pERK-mediated IL8 secretion can enhance the migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells.	Cisplatin	69-78	C-X-C motif chemokine ligand 8	Homo sapiens	14-17
34847866-4	2021	We hypothesized that IL8 might regulate migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells through the ERK pathway.	Cisplatin	65-74	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
34847866-11	2021	IL8 secreted by CD10H HN6 promoted migration and invasion and restored tumor chemosensitivity via the p-ERK signaling pathway, while the inhibition of IL8 increased the chemosensitivity to cisplatin.	Cisplatin	189-198	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
34847866-11	2021	IL8 secreted by CD10H HN6 promoted migration and invasion and restored tumor chemosensitivity via the p-ERK signaling pathway, while the inhibition of IL8 increased the chemosensitivity to cisplatin.	Cisplatin	189-198	C-X-C motif chemokine ligand 8	Homo sapiens	151-154
34847866-12	2021	CONCLUSIONS: IL8 secretion by CD10 positive cells promotes migration, invasion, and cisplatin resistance of OSCC via the p-ERK signaling pathway.	Cisplatin	84-93	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
34670781-8	2021	Accordingly, ectopic expression of CXCL8 in ALKBH5-deficient GBM cells partially restored TAM recruitment and tumor progression.	tam	90-93	C-X-C motif chemokine ligand 8	Homo sapiens	35-40
34459104-8	2021	Treatment of HFLS-RA cells with OMTH prevented TNF-alpha mediated elevation of IL-1beta, IL-6 and IL-8.	omth	32-36	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
34643021-4	2021	Moreover, we demonstrated, for the first time in human adipocytes, that cells exposure to PA induced gene expression of proinflammatory cytokines TNF-alpha, IL-6, IL-8, and MCP-1.	Palmitic Acid	90-92	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
34851004-0	2022	Sulfation pattern dependent Iron (III) mediated interleukin-8 glycan binding.	Iron	28-32	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
34851004-0	2022	Sulfation pattern dependent Iron (III) mediated interleukin-8 glycan binding.	Polysaccharides	62-68	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
34851004-1	2022	Cytokines such as interleukin-8 activate the immune system during infection and interact with sulfated glycosaminoglycans with specific sulfation patterns.	Glycosaminoglycans	103-121	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
34851004-3	2022	We evaluated the effect of both hyaluronan sulfation pattern and Fe3+ on interleukin-8 binding by electrochemical impedance spectroscopy and surface characterizations.	Hyaluronic Acid	32-42	C-X-C motif chemokine ligand 8	Homo sapiens	73-86
34851004-3	2022	We evaluated the effect of both hyaluronan sulfation pattern and Fe3+ on interleukin-8 binding by electrochemical impedance spectroscopy and surface characterizations.	ferric sulfate	65-69	C-X-C motif chemokine ligand 8	Homo sapiens	73-86
34083105-0	2021	Corrigendum to "IL-8 negatively regulates ABCA1 expression and cholesterol efflux via upregulating miR-183 in THP-1 macrophage-derived foam cells" (Cytokine 122 (2019) 154385).	Cholesterol	63-74	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
34626802-5	2021	The IFNgamma-induced IL-8 expression is dependent on JAK1, STAT1, and p65 NFkappaB, and is associated with an increased occupancy of K314/315 acetylated p65 NFkappaB and Ser-727 phosphorylated STAT1 at the IL-8 promoter.	Serine	170-173	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
34308659-5	2021	Methyl mercury treatment significantly induced the adhesion of monocyte to HMEC-1 endothelial cells, a critical step in atherosclerosis, while also upregulating the expression of proinflammatory cytokines interleukin-6, interleukin-8.	methyl mercury	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	220-233
34780879-6	2021	Fluoride reduced mitochondrial antioxidant enzyme activities and SOD2 acetylation by downregulating Sirt3 expression in the brains of mice and NaF-treated SH-SY5Y cells.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	143-146
34780879-7	2021	Moreover, fluoride lowered mtDNA transcription and induced mitochondrial dysfunction along with increased FoxO3A acetylation in the brains of mice and NaF-treated SH-SY5Y cells.	Fluorides	10-18	C-X-C motif chemokine ligand 8	Homo sapiens	151-154
34636179-11	2021	Interleukin-6 (IL-6) and IL-8 production by stimulated ECs were unaltered by incubation with macrolides, whereas Clarithromycin exposure significantly decreased IL-6 gene expression.	Clarithromycin	113-127	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
34153179-10	2021	However, ASA was inflammatory above its therapeutic window, increasing the levels of PGE2 and IL-8 above those seen with bradykinin stimulation alone.	Aspirin	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
34607230-8	2021	Besides, in patients, receiving lovastatin the CRP, IL-6, IL-8 levels were significantly decreased from T1 to T3 than to the control group.	Lovastatin	32-42	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
34626802-5	2021	The IFNgamma-induced IL-8 expression is dependent on JAK1, STAT1, and p65 NFkappaB, and is associated with an increased occupancy of K314/315 acetylated p65 NFkappaB and Ser-727 phosphorylated STAT1 at the IL-8 promoter.	Serine	170-173	C-X-C motif chemokine ligand 8	Homo sapiens	206-210
34950767-4	2021	Using the human keratinocyte-derived cell line HaCaT, the present in vitro studies indicate that pretreatment of HaCaT keratinocytes with PAFR agonist ester can synergize with low fluences of UVB to generate high levels of MVP as well as IL-8 protein.	Esters	151-156	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
34019775-6	2021	CoCl2 caused an increase of IL-8 in HaCaT cells, while the induction of also IL-13 and IL-1beta was observed in THP-1 cells and co-cultures.	cobaltous chloride	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
34879788-4	2021	Generalized estimating equation was used to evaluate the association between exposure to PM2.5 and NO2 and the following serum cytokine levels on the 7 days preceding clinical assessment and serum collection: MCP1, IL-6, IL-8, IL-10, IL-17, IFN-alpha, and TNF-alpha.	pm2.5	89-94	C-X-C motif chemokine ligand 8	Homo sapiens	221-225
34879788-4	2021	Generalized estimating equation was used to evaluate the association between exposure to PM2.5 and NO2 and the following serum cytokine levels on the 7 days preceding clinical assessment and serum collection: MCP1, IL-6, IL-8, IL-10, IL-17, IFN-alpha, and TNF-alpha.	Nitrogen Dioxide	99-102	C-X-C motif chemokine ligand 8	Homo sapiens	221-225
34798932-4	2021	The pro-inflammatory response in terms of IL-8 expression was strongest in cells exposed to Bentonite, whereas surface modification resulted in decreased toxicity in both cell lines when exposed to Nanofil9 and NanofilSE3000.	Bentonite	92-101	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
34666245-6	2021	Here, we show that Trelagliptin mitigates IL-1beta-induced production of inflammatory cytokines such as interleukin 6 (IL-6), interleukin 8 (IL-8), and tumor necrosis factor-alpha (TNF-alpha) in human chondrocytes.	trelagliptin	19-31	C-X-C motif chemokine ligand 8	Homo sapiens	126-139
34666245-6	2021	Here, we show that Trelagliptin mitigates IL-1beta-induced production of inflammatory cytokines such as interleukin 6 (IL-6), interleukin 8 (IL-8), and tumor necrosis factor-alpha (TNF-alpha) in human chondrocytes.	trelagliptin	19-31	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
34856488-5	2021	The results showed that endosulfan significantly promoted cell proliferation, accompanied with the decrease of p27 mRNA expression and the increase in the mRNA expression levels of p21 and inflammatory factors IL-6/IL-8.	Endosulfan	24-34	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
34624807-9	2021	CONCLUSION: This systematic review broadly reports that, in contrast to other classes of phytochemicals, flavonoids have the greatest therapeutic potential against arthritis by modulating the expression of pro-inflammatory TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17, as well as anti-inflammatory IL-2 and IL-10 cytokines, through the suppression of dynamic inflammatory biomarkers.	Flavonoids	105-115	C-X-C motif chemokine ligand 8	Homo sapiens	250-254
34941643-1	2021	This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ((18F)NaF) to understand bone physiology.	Sodium Fluoride	214-229	C-X-C motif chemokine ligand 8	Homo sapiens	236-239
34697842-3	2021	Results of ELISA experiments revealed that Garcinia kola extract (6.25, 12.5, and 25 mug/ml) and garcinoic acid (1.25, 2.5, and 5 muM) significantly reduced SARS-CoV-2 spike protein S1-induced secretion of TNFalpha, IL-6, IL-1beta, and IL-8 in PBMCs.	garcinoic acid	97-111	C-X-C motif chemokine ligand 8	Homo sapiens	236-240
34933727-9	2021	Other pivotal features of melatonin are its anti-inflammatory properties, which decrease pro-inflammatory cytokines expression and factors such as IL-8, IL-6, and TNF.	Melatonin	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
34943473-3	2021	In addition, recent studies have suggested that microcalcification revealed by 18F-sodium fluoride (NaF) may be more sensitive at detecting atherogenic changes compared to FDG-PET.	18f-sodium fluoride	79-98	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
34880922-6	2021	Noscapine can reduce endothelial cell migration in the brain by inhibiting endothelial cell activator interleukin 8 (IL-8).	Noscapine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	102-115
34880922-6	2021	Noscapine can reduce endothelial cell migration in the brain by inhibiting endothelial cell activator interleukin 8 (IL-8).	Noscapine	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
34885115-15	2021	CAFs derived from Osimertinib-resistant cells secreted more IL-6, IL-8, and hepatocyte growth factor (HGF), expressed stronger CAF markers including alpha-smooth muscle actin (alpha-SMA), fibroblast activation protein (FAP) plus platelet-derived growth factor receptor (PDGFR), and enhanced stemness and Osimertinib resistance in NSCLC cells.	osimertinib	18-29	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
34943005-6	2021	Using ELISA, we demonstrate that the disulfide bridge between the enzymatic cysteines is required to allow improved TLR4-dependent IL-8 secretion.	Disulfides	37-46	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
34943005-6	2021	Using ELISA, we demonstrate that the disulfide bridge between the enzymatic cysteines is required to allow improved TLR4-dependent IL-8 secretion.	Cysteine	76-85	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
34826187-9	2022	Taken together, these observations suggest that SIRT1 stabilized through phosphorylation on serine 27 exerts oncogenic effects at least partly through deacetylation-dependent activation of Snail and subsequent transcription of IL-6 and IL-8 in human colon cancer cells.	Serine	92-98	C-X-C motif chemokine ligand 8	Homo sapiens	236-240
34884486-11	2021	Preincubation with heparin, autotaxin (ATX) inhibitor HA130 or lysophosphatidic acid (LPA) receptor antagonist Ki16425 reduced PLA1A-induced-secretion of IL-8.	Heparin	19-26	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
34886097-7	2021	In addition, both SK-119 and SH-29 were able to reduce DPM-induced IL-8 hypersecretion in pharmacologically relevant concentrations.	sk-119	18-24	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
34886097-7	2021	In addition, both SK-119 and SH-29 were able to reduce DPM-induced IL-8 hypersecretion in pharmacologically relevant concentrations.	sh-29	29-34	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
34886097-7	2021	In addition, both SK-119 and SH-29 were able to reduce DPM-induced IL-8 hypersecretion in pharmacologically relevant concentrations.	dpm	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
34884486-11	2021	Preincubation with heparin, autotaxin (ATX) inhibitor HA130 or lysophosphatidic acid (LPA) receptor antagonist Ki16425 reduced PLA1A-induced-secretion of IL-8.	HA130	54-59	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
34884486-11	2021	Preincubation with heparin, autotaxin (ATX) inhibitor HA130 or lysophosphatidic acid (LPA) receptor antagonist Ki16425 reduced PLA1A-induced-secretion of IL-8.	lysophosphatidic acid	63-84	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
34884486-11	2021	Preincubation with heparin, autotaxin (ATX) inhibitor HA130 or lysophosphatidic acid (LPA) receptor antagonist Ki16425 reduced PLA1A-induced-secretion of IL-8.	lysophosphatidic acid	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
34884486-11	2021	Preincubation with heparin, autotaxin (ATX) inhibitor HA130 or lysophosphatidic acid (LPA) receptor antagonist Ki16425 reduced PLA1A-induced-secretion of IL-8.	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid	111-118	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
34582847-5	2021	LPC stimulation resulted in elevated secretion of interleukin (IL)-6 and IL-8 in HUVECs, accompanied with the activation of ER stress and NF-kappaB pathway.	lpc	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
34834886-13	2021	In addition, magnolol displayed inhibitory effects towards IL-1beta, IL-8 and TNF-alpha released from lipopolysaccharide (LPS)-stimulated human neutrophils, while honokiol only decreased IL-1beta secretion, compared to the untreated control.	magnolol	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
34869555-9	2021	Results: Compared with the fasting group, the CHO group exhibited a decrease in interleukin 6 (IL-6) levels on days 1 and 7 (75.47 and 7.06 pg/mL, respectively), IL-8 levels on day 1 (274.61 pg/mL) and tumour necrosis factor (TNF) levels on days 1, 3, and 7 (11.16, 9.55, and 9.67 pg/mL, respectively).	CAV protocol	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
34869555-13	2021	Conclusion: Preoperative CHO and drinking water are associated with decreased levels of IL-6, IL-8, and TNF.	CAV protocol	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
34869555-13	2021	Conclusion: Preoperative CHO and drinking water are associated with decreased levels of IL-6, IL-8, and TNF.	Water	42-47	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
34833991-12	2021	Finally, the pro-inflammatory cytokines (IL-1beta, IL-6, and IL-8) released by PBMCs triggered by SARS-CoV-2 were decreased after treatment with curcumin.	Curcumin	145-153	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
34799554-4	2021	ADT induced the secretion of WNT4 which upon engagement of TCF7L1 in prostate cancer cells, enhanced IL-8 and CXCR2 expressions.	adt	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
34816902-2	2021	This study aimed to compare the effects of conventional (sodium fluoride (NaF)) and stannous fluoride (SnF2)-containing dentifrices on reducing erosive tooth wear (ETW).	Sodium Fluoride	57-72	C-X-C motif chemokine ligand 8	Homo sapiens	74-77
34732192-0	2021	Nicotine regulates autophagy of human periodontal ligament cells through alpha7 nAchR that promotes secretion of inflammatory factors IL-1beta and IL-8.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
34785925-8	2021	Furthermore, blocking Stat3 signaling pathway by treatment with TSA and/or small molecule compound Stattic of an p-Stat3 inhibitor effectively abrogated LPS-induced tumorosphere forming with decrease of IL-6, IL-8 and stemness biomarkers CD44, SOX-2 expression.	trichostatin A	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	209-213
34785925-10	2021	TSA could prevent, at least in part, the LPS-induced malignant transformation by targeting p-Stat3/c-Myc signaling pathway and reducing inflammatory IL-6, IL-8.	trichostatin A	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
34769415-6	2021	In addition, pretreatment with naringenin might inhibit the secretion of TNF-alpha, IL-6, and IL-8, as well as the proteins cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) via the suppression of NF-kappaB and mitogen-activated protein kinase (MAPK) signaling in ethanol-stimulated stomach epithelial KATO III cells.	naringenin	31-41	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
34668373-9	2021	The significant increase in endocytosed Ta-Au resulted in a 20% decrease in viability, and a 4-fold increase in IL-8 cytokine secretion when cultured on soft PU SDCs at ALI.	ta-au	40-45	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
34732192-3	2021	To investigated the mechanism through which nicotine regulates autophagy of human periodontal ligament cells (hPDLCs) through the alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) and how autophagy further regulates the release of IL-1beta and IL-8 secretion in hPDLCs.	Nicotine	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	249-253
34732192-7	2021	RT-qPCR and ELISA results revealed a noticeable rise in the release of inflammatory factors IL-1beta and IL-8 from hPDLCs in response to nicotine.	Nicotine	137-145	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
34732192-8	2021	RT-qPCR and ELISA results showed that nicotine can significantly up-regulate the release of inflammatory factors IL-1beta and IL-8 in hPDLCs, and this effect can be inhibited by 3-MA (p < 0.05).	Nicotine	38-46	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
34726293-9	2022	RESULTS AND DISCUSSION: After 12 weeks, the ethosuximide group showed a statistically and significantly greater reduction in the serum levels of TNF-alpha, IL-6, IL-8, faecal myeloperoxidase and faecal NGAL in comparison with the control group after the treatment.	Ethosuximide	44-56	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
34795863-6	2021	A subsequent functional assay using the MDA-MB-231 cell line demonstrated that the d-galactal-benzimidazole hybrid and the analogous galactoside derivative reduced the secretion of the proinflammatory cytokines interleukin-6 (IL-6) and IL-8 in a dose-dependent manner.	d-galactal-benzimidazole	83-107	C-X-C motif chemokine ligand 8	Homo sapiens	236-240
34795863-6	2021	A subsequent functional assay using the MDA-MB-231 cell line demonstrated that the d-galactal-benzimidazole hybrid and the analogous galactoside derivative reduced the secretion of the proinflammatory cytokines interleukin-6 (IL-6) and IL-8 in a dose-dependent manner.	Galactosides	133-144	C-X-C motif chemokine ligand 8	Homo sapiens	236-240
34539828-4	2021	ALA/DHLA reduce the levels of pro-inflammatory cytokines (IL-1beta, IL-6, IL-8 and IL-17), while increasing the secretion of anti-inflammatory cytokines (IL-10).	Thioctic Acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
34126877-8	2021	O3-induced pro-inflammatory gene expression for CXCL2 and CXCL8/IL8 was further enhanced in NLRP2 knockout cells, suggesting a negative regulatory role.	Ozone	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	58-63
34126877-8	2021	O3-induced pro-inflammatory gene expression for CXCL2 and CXCL8/IL8 was further enhanced in NLRP2 knockout cells, suggesting a negative regulatory role.	Ozone	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
34126877-9	2021	Reconstitution of NLRP2 KO cells with K1019R mutant NLRP2 partially blocked SecoA adduction and enhanced O3-induced IL-8 release as compared to wild type NLRP2.	Ozone	105-107	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
34601318-1	2021	OBJECTIVE: Sodium fluoride (NaF) plays an important role in preventing dental caries.	Sodium Fluoride	11-26	C-X-C motif chemokine ligand 8	Homo sapiens	28-31
34310083-11	2021	Azithromycin concentration was positively correlated with IL-8 (r = 0.38, p = 0.03), IL1a (r = 0.39, p = 0.03), and IL-1b (r = 0.36, p = 0.04) in amniotic fluid.	Azithromycin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
34499917-8	2021	Hcy exposure increased CBS protein expression, hydrogen sulfide levels and pro-inflammatory cytokines, modulating CBS by silencing did not alter H2S levels, but inhibition of CSE with PAG inhibited H2S production and decreased cytokine (IL-6 and IL-8) levels.	Homocysteine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	246-250
34837919-12	2021	A significant decrease in NAF was also observed in Temozolomide (p < 0.05) and Opuntiol (p < 0.05) treated cells.	Temozolomide	51-63	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
34837919-12	2021	A significant decrease in NAF was also observed in Temozolomide (p < 0.05) and Opuntiol (p < 0.05) treated cells.	opuntiol	79-87	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
34507119-4	2021	First, we evaluated the effect of lupeol (100 microM) on inflammatory response induced by lipopolysaccharide (LPS) in retinal pigment epithelium cells (ARPE-19) by measuring levels of released interleukins (IL-6 and IL-8).	lupeol	34-40	C-X-C motif chemokine ligand 8	Homo sapiens	216-220
34507119-8	2021	Treatment with lupeol (100 microM) significantly decreased IL-6 and IL-8 levels in comparison to untreated LPS-activated ARPE-19 cells.	lupeol	15-21	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
34725321-12	2021	In addition, activation of the CXCL8 receptor CXCR1 during thapsigargin exposure supported subsequent sphere formation by cancer cells.	Thapsigargin	59-71	C-X-C motif chemokine ligand 8	Homo sapiens	31-36
34539828-4	2021	ALA/DHLA reduce the levels of pro-inflammatory cytokines (IL-1beta, IL-6, IL-8 and IL-17), while increasing the secretion of anti-inflammatory cytokines (IL-10).	dihydrolipoic acid	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
34600651-7	2021	CB-B inhibited the release of cytokine IL-8, and both products were effective in restoring the TEER.	cb-b	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
34609010-7	2021	Our results showed that berberine-LCNs significantly reduced the expression of CCl-20, CXCL-8 and HO-1 at dose of 5microM.	Berberine	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	87-93
34059950-8	2021	RESULTS: VEGF, MCP-1, IL-8, and IL-6 levels in the aqueous humor of patients with RVO-ME were significantly higher compared with control and were positively correlated with the CRTBT.	rvo-me	82-88	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
34059950-12	2021	CONCLUSION: VEGF, MCP-1, IL-8, and IL-6 levels were significantly increased in patients with RVO-ME and were positively correlated with ME.	rvo-me	93-99	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
34609010-7	2021	Our results showed that berberine-LCNs significantly reduced the expression of CCl-20, CXCL-8 and HO-1 at dose of 5microM.	lcns	34-38	C-X-C motif chemokine ligand 8	Homo sapiens	87-93
34609010-8	2021	Collectively, our findings suggest that berberine-LCNs have inhibitory effect on inflammation/oxidative stress related cytokines i.e. CCL20, CXCL-8, and HO-1 which could be a novel therapeutic target for the management of lung cancer.	Berberine	40-49	C-X-C motif chemokine ligand 8	Homo sapiens	141-147
34609010-11	2021	Our study showed that Berberine LCNs significantly downregulate the expression of CXCL-8, CCL-20 and HO-1 which suggests that Berberine loaded nanoparticles could be a promising therapeutic alternative for the management of lung cancer.	berberine lcns	22-36	C-X-C motif chemokine ligand 8	Homo sapiens	82-88
34609010-11	2021	Our study showed that Berberine LCNs significantly downregulate the expression of CXCL-8, CCL-20 and HO-1 which suggests that Berberine loaded nanoparticles could be a promising therapeutic alternative for the management of lung cancer.	Berberine	126-135	C-X-C motif chemokine ligand 8	Homo sapiens	82-88
34438042-2	2021	Here we demonstrate that the hydrophobic bile acid, deoxycholic acid (DCA), stimulated the production of IL-6 and IL-8 mRNA and protein in Het-1A, a model of normal oesophageal cells.	Bile Acids and Salts	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
34438042-2	2021	Here we demonstrate that the hydrophobic bile acid, deoxycholic acid (DCA), stimulated the production of IL-6 and IL-8 mRNA and protein in Het-1A, a model of normal oesophageal cells.	Deoxycholic Acid	52-68	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
34438042-2	2021	Here we demonstrate that the hydrophobic bile acid, deoxycholic acid (DCA), stimulated the production of IL-6 and IL-8 mRNA and protein in Het-1A, a model of normal oesophageal cells.	Deoxycholic Acid	70-73	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
34438042-3	2021	DCA-induced production of IL-6 and IL-8 was attenuated by pharmacologic inhibition of the Protein Kinase C (PKC), MAP kinase, tyrosine kinase pathways, by the cholesterol sequestering agent, methyl-beta-cyclodextrin (MCD) and by the hydrophilic bile acid, ursodeoxycholic acid (UDCA).	Deoxycholic Acid	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
34438042-4	2021	The cholesterol-interacting agent, nystatin, which binds cholesterol without removing it from the membrane, synergized with DCA to induce IL-6 and IL-8.	Cholesterol	4-15	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
34628106-5	2021	In human placental tissue culture, treatment with BHB suppressed the secretion levels of inflammatory cytokines, such as interleukin (IL)-1beta, IL-6, and IL-8, but did not affect the mRNA expression levels of NLRP3 inflammasome-associated factors.	3-Hydroxybutyric Acid	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
34438042-4	2021	The cholesterol-interacting agent, nystatin, which binds cholesterol without removing it from the membrane, synergized with DCA to induce IL-6 and IL-8.	Nystatin	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
34438042-4	2021	The cholesterol-interacting agent, nystatin, which binds cholesterol without removing it from the membrane, synergized with DCA to induce IL-6 and IL-8.	Deoxycholic Acid	124-127	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
34438042-7	2021	while knockdown of caveolin-1 expression using siRNA resulted in a decreased level of IL-8 production in response to DCA.	Deoxycholic Acid	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
34438042-8	2021	Taken together, these results demonstrate that DCA stimulates IL-6 and IL-8 production in oesophageal cells via lipid raft-associated signaling.	Deoxycholic Acid	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
34771621-4	2021	In this study, we show that gemcitabine stimulates the expression of pro-inflammatory cytokines, such as IL6 and IL8, under the influence of the CD95/CD95L system and the pharmacological inhibitor, sCD95Fc, substantially reduced the expression in two PDAC cell lines, PancTuI-luc and A818-4.	gemcitabine	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
34106437-5	2021	Progesterone stimulation decreased the expression of TLR2, TLR5, and Nod2 genes (alone and/or in combination with TLR/NLR agonists) and decreased the expression of IL-1beta and IL-8 genes increased by stimulation with specific agonists for TLR2, TLR4, TLR5, Nod1, and Nod2.	Progesterone	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
34106437-6	2021	Moreover, progesterone decreased thrombin-induced IL-8 gene expression.	Progesterone	10-22	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
34533029-3	2021	In our study, miR-10a-5p overexpression inhibited the proliferation, migration, and IL-6/IL-8 level of LX-2 and human liver cancer fibroblasts (HLCFs) cells.	mir-10a-5p	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
34455857-3	2021	Methods: In a multicenter cross-sectional observational cohort study, patients with TAVI or bioprosthetic SAVR underwent baseline echocardiography, CT angiography and 18F-sodium fluoride (18F-NaF) positron emission tomography (PET).	18f-sodium fluoride	167-186	C-X-C motif chemokine ligand 8	Homo sapiens	192-195
34715784-5	2021	IL-6 and IL-8 as pro-inflammatory cytokines released during surgery, were lowered in mean 28-fold and 52-fold during the Catuvab procedure, respectively, whereas Catumaxomab antibody was detected in 8 of 16 of the final EC products at a considerable decreased and uncritical residual amount (37 ng in mean).	catuvab	121-128	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
34835369-8	2021	Overexpression of the mouse macrophage inflammatory protein 2 mRNA in the colon as a functional homolog of human interleukin-8 was decreased by the orally administered EPS.	eps	168-171	C-X-C motif chemokine ligand 8	Homo sapiens	113-126
34769627-7	2021	Naive THP-1 cells produced significantly elevated levels of IL-1beta, IL-8, and TNF-alpha when exposed to ethyl maltol and hexanal.	ethyl maltol	106-118	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
34737896-8	2021	We found that pentosidine induced upregulation of CXCL2, IL8, and MMP12 mRNA expression (inflammatory and elastotic markers, respectively).	pentosidine	14-25	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
34768873-8	2021	Graphene exposure (10 microg/mL) for 24 h significantly increased levels of pro-inflammatory cytokines IFNgamma, IL-8, IL-17, IL-6, IL-9, MIP-1alpha, and Eotaxin.	Graphite	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
34769627-7	2021	Naive THP-1 cells produced significantly elevated levels of IL-1beta, IL-8, and TNF-alpha when exposed to ethyl maltol and hexanal.	n-hexanal	123-130	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
34622888-5	2021	Based on MD simulations, we propose that the magnitude of cation excess (which is salt specific) depends on the ability of the electrolyte to perturb the water network at the DNA interface: In the NaF atmosphere, the ions reduce the strength of interactions between water and the DNA more than in case of a NaCl electrolyte.	Salts	82-86	C-X-C motif chemokine ligand 8	Homo sapiens	197-200
34622888-5	2021	Based on MD simulations, we propose that the magnitude of cation excess (which is salt specific) depends on the ability of the electrolyte to perturb the water network at the DNA interface: In the NaF atmosphere, the ions reduce the strength of interactions between water and the DNA more than in case of a NaCl electrolyte.	Water	154-159	C-X-C motif chemokine ligand 8	Homo sapiens	197-200
34622888-5	2021	Based on MD simulations, we propose that the magnitude of cation excess (which is salt specific) depends on the ability of the electrolyte to perturb the water network at the DNA interface: In the NaF atmosphere, the ions reduce the strength of interactions between water and the DNA more than in case of a NaCl electrolyte.	Water	266-271	C-X-C motif chemokine ligand 8	Homo sapiens	197-200
34666750-10	2021	LABA/GCS attenuation of Poly I:C or imiquimod-induced IL-6 and IL-8 were potentiated with ABCC4 and PDE4 inhibition, which was greater when ABCC4 and PDE4 inhibition was combined.	Imiquimod	36-45	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
34666758-12	2021	TNF-alpha or flagellin-induced IL-8 levels were also significantly reduced with SC79 treatment.	SC79	80-84	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
34666750-10	2021	LABA/GCS attenuation of Poly I:C or imiquimod-induced IL-6 and IL-8 were potentiated with ABCC4 and PDE4 inhibition, which was greater when ABCC4 and PDE4 inhibition was combined.	Poly I	24-30	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
34590836-7	2021	Also, we found that AZ3451 attenuated ox-LDL-induced expression and production of pro-inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interleukin-8 (IL-8).	AZ3451	20-26	C-X-C motif chemokine ligand 8	Homo sapiens	184-197
34590836-7	2021	Also, we found that AZ3451 attenuated ox-LDL-induced expression and production of pro-inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interleukin-8 (IL-8).	AZ3451	20-26	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
34733807-8	2021	The univariate analysis showed that there were significant differences between the PB group and the non-PB group in LDH, D-dimer, CD3+CD4+(%), CD3+CD4+/CD3+CD8+, CD3 count, CD4 count, CD8 count, complement 3, IL8, IL-1beta, IL-2, IL-10 (P < 0.05).	pladienolide B	83-85	C-X-C motif chemokine ligand 8	Homo sapiens	209-212
34733276-8	2021	In vitro treatment of PBMCs from either SLE patients or healthy controls with 17beta-estradiol at physiological concentration (~50 pg/ml) also significantly increased secretion of many pro-inflammatory cytokines and chemokines (IL-6, IL-12, IL-17, IL-8, IFN-gamma; MIP1alpha, and MIP1beta) in both groups.	Estradiol	78-94	C-X-C motif chemokine ligand 8	Homo sapiens	248-252
34655103-11	2022	LPS exposure evoked viability reduction, increased LDH release and apoptosis, and induced production of inflammatory cytokines (IL-6, IL-8, and MCP-1) and MUC5AC hypersecretion in human AECs, which were alleviated by euxanthone.	euxanthone	217-227	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
34681839-2	2021	Gold standard therapy temozolomide (TMZ) is known to induce upregulation of IL8/CXCL2/CXCR2 signaling that promotes tumor progression and angiogenesis.	Temozolomide	22-34	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
34681839-2	2021	Gold standard therapy temozolomide (TMZ) is known to induce upregulation of IL8/CXCL2/CXCR2 signaling that promotes tumor progression and angiogenesis.	Temozolomide	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
34754605-3	2021	During the past decade, numerous papers have described a major role for sodium 18F-fluoride (NaF) as another tracer for assessing this vascular disease.	SODIUM FLUORIDE F-18	72-91	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
34425162-4	2021	Pretreatment of HNE cells with the specific vacuolar H+-ATPase inhibitor bafilomycin A1 reduced the RV-C03 RNA levels in the ASL; inflammatory cytokines, including interleukin (IL)-1beta, IL-6 and IL-8, in the supernatant; the mRNA expression of the RV-C receptor cadherin-related family member 3 (CDHR3) in the cells; and the number of acidic endosomes where RV-B RNA enters the cytoplasm.	bafilomycin A1	73-87	C-X-C motif chemokine ligand 8	Homo sapiens	197-201
34659651-0	2021	18F-Sodium Fluoride (NaF) Uptake in Calcified Bladder Carcinoma: Double Density Sign 18F-Sodium fluoride (NaF) is primarily a skeletal imaging agent which can be localized in extraosseous calcified foci.	18f-sodium fluoride	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
34659651-0	2021	18F-Sodium Fluoride (NaF) Uptake in Calcified Bladder Carcinoma: Double Density Sign 18F-Sodium fluoride (NaF) is primarily a skeletal imaging agent which can be localized in extraosseous calcified foci.	18f-sodium fluoride	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	106-109
34659651-0	2021	18F-Sodium Fluoride (NaF) Uptake in Calcified Bladder Carcinoma: Double Density Sign 18F-Sodium fluoride (NaF) is primarily a skeletal imaging agent which can be localized in extraosseous calcified foci.	18f-sodium fluoride	85-104	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
34659651-0	2021	18F-Sodium Fluoride (NaF) Uptake in Calcified Bladder Carcinoma: Double Density Sign 18F-Sodium fluoride (NaF) is primarily a skeletal imaging agent which can be localized in extraosseous calcified foci.	18f-sodium fluoride	85-104	C-X-C motif chemokine ligand 8	Homo sapiens	106-109
34672097-8	2022	The expression of IL8 gene was reduced by all applied concentrations of ClO2 .	Chlorous acid	72-76	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
34601878-9	2021	This result is explained by different interactions of each salt with the micelle: whereas NaF interacts primarily with PEO chains, NaCl may also partition to the PPO/PEO interface in low levels, increasing micelle surface tension, scission energy, and contour length.	Salts	59-63	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
34754406-15	2021	Severity of mucosal inflammatory changes is proportional to luminal (NO), which might be tied to IL-8 production.	Phenobarbital	60-67	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
34643794-14	2022	In addition, bevacizumab reduced the secretion of IL-8 and TNFalpha after Poly I:C stimulation at selected time points.	Poly I-C	74-82	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
34690806-10	2021	Transfection with small interfering RNA (siRNA) targeting STIM1 and pretreatment with NAC alleviated CSE-induced increase in intracellular Ca2+ levels and IL-8 expression.	Acetylcysteine	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
34637509-9	2022	Specific fatty acids including 14:0 and long chain n-6 fatty acids being negatively and positively, respectively, associated with IL-8 were also found to be positively associated with SAA.	Fatty Acids	9-20	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
34637509-9	2022	Specific fatty acids including 14:0 and long chain n-6 fatty acids being negatively and positively, respectively, associated with IL-8 were also found to be positively associated with SAA.	Fatty Acids, Omega-6	51-66	C-X-C motif chemokine ligand 8	Homo sapiens	130-134
34690806-0	2021	Cigarette Smoke Promotes Interleukin-8 Production in Alveolar Macrophages Through the Reactive Oxygen Species/Stromal Interaction Molecule 1/Ca2+ Axis.	Oxygen	95-101	C-X-C motif chemokine ligand 8	Homo sapiens	25-38
34690806-4	2021	Our results showed that the reactive oxygen species (ROS)/STIM1/Ca2+ axis played a critical role in CS-induced secretion of interleukin (IL)-8 in human alveolar macrophages.	Reactive Oxygen Species	28-51	C-X-C motif chemokine ligand 8	Homo sapiens	124-142
34680563-7	2021	L-HCV promotes cell growth and alters cell adhesion and chemokine signaling via CXCL8-mediated-SRC regulation.	l-hcv	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
34625847-9	2022	The average interleukin-8 (IL-8) concentrations were significantly lower in the fluorometholone (4.80 pg/mL), ketorolac tromethamine (4.84 pg/mL), and fluorometholone + ketorolac tromethamine (4.68 pg/mL) groups than in the control group (6.83 pg/mL).	Fluorometholone	80-95	C-X-C motif chemokine ligand 8	Homo sapiens	12-25
34625847-9	2022	The average interleukin-8 (IL-8) concentrations were significantly lower in the fluorometholone (4.80 pg/mL), ketorolac tromethamine (4.84 pg/mL), and fluorometholone + ketorolac tromethamine (4.68 pg/mL) groups than in the control group (6.83 pg/mL).	Fluorometholone	80-95	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
34625847-9	2022	The average interleukin-8 (IL-8) concentrations were significantly lower in the fluorometholone (4.80 pg/mL), ketorolac tromethamine (4.84 pg/mL), and fluorometholone + ketorolac tromethamine (4.68 pg/mL) groups than in the control group (6.83 pg/mL).	Ketorolac Tromethamine	110-132	C-X-C motif chemokine ligand 8	Homo sapiens	12-25
34625847-9	2022	The average interleukin-8 (IL-8) concentrations were significantly lower in the fluorometholone (4.80 pg/mL), ketorolac tromethamine (4.84 pg/mL), and fluorometholone + ketorolac tromethamine (4.68 pg/mL) groups than in the control group (6.83 pg/mL).	Ketorolac Tromethamine	110-132	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
34625847-9	2022	The average interleukin-8 (IL-8) concentrations were significantly lower in the fluorometholone (4.80 pg/mL), ketorolac tromethamine (4.84 pg/mL), and fluorometholone + ketorolac tromethamine (4.68 pg/mL) groups than in the control group (6.83 pg/mL).	Fluorometholone	151-166	C-X-C motif chemokine ligand 8	Homo sapiens	12-25
34625847-9	2022	The average interleukin-8 (IL-8) concentrations were significantly lower in the fluorometholone (4.80 pg/mL), ketorolac tromethamine (4.84 pg/mL), and fluorometholone + ketorolac tromethamine (4.68 pg/mL) groups than in the control group (6.83 pg/mL).	Fluorometholone	151-166	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
34625847-9	2022	The average interleukin-8 (IL-8) concentrations were significantly lower in the fluorometholone (4.80 pg/mL), ketorolac tromethamine (4.84 pg/mL), and fluorometholone + ketorolac tromethamine (4.68 pg/mL) groups than in the control group (6.83 pg/mL).	Ketorolac Tromethamine	169-191	C-X-C motif chemokine ligand 8	Homo sapiens	12-25
34625847-9	2022	The average interleukin-8 (IL-8) concentrations were significantly lower in the fluorometholone (4.80 pg/mL), ketorolac tromethamine (4.84 pg/mL), and fluorometholone + ketorolac tromethamine (4.68 pg/mL) groups than in the control group (6.83 pg/mL).	Ketorolac Tromethamine	169-191	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
34625847-11	2022	CONCLUSION: Preoperative fluorometholone instillation reduced IL-8, and ketorolac tromethamine instillation reduced IL-8 and PGE2, in aqueous humor of patients undergoing femtosecond laser surgery, with the combination of both eyedrops being more effective than either alone.	Fluorometholone	25-40	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
34625847-11	2022	CONCLUSION: Preoperative fluorometholone instillation reduced IL-8, and ketorolac tromethamine instillation reduced IL-8 and PGE2, in aqueous humor of patients undergoing femtosecond laser surgery, with the combination of both eyedrops being more effective than either alone.	Ketorolac Tromethamine	72-94	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
34626114-6	2022	The results of q-PCR analysis showed that metformin reduced NF-kappaB mediated inflammatory response including decreased level of pro-inflammatory cytokine IL-8 and increased expression of anti-inflammatory cytokine IL-10 in gut of the fish with natural aging and poly I:C-injected 6-month-old fish.	Metformin	42-51	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
34690806-4	2021	Our results showed that the reactive oxygen species (ROS)/STIM1/Ca2+ axis played a critical role in CS-induced secretion of interleukin (IL)-8 in human alveolar macrophages.	Reactive Oxygen Species	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	124-142
34690806-11	2021	Furthermore, pretreatment with SKF-96365 and 2-APB, the inhibitors of Ca2+ influx, suppressed CSE-induced secretion of IL-8.	1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole	31-40	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
34690806-11	2021	Furthermore, pretreatment with SKF-96365 and 2-APB, the inhibitors of Ca2+ influx, suppressed CSE-induced secretion of IL-8.	2-aminoethoxydiphenyl borate	45-50	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
34690806-12	2021	In conclusion, our study demonstrates that CSE-induced ROS production may increase the expression of STIM1 in macrophages, which further promotes the release of IL-8 by regulating Ca2+ entry.	Reactive Oxygen Species	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
34303665-1	2021	The aim of the current study was to perform a meta-analysis of randomized clinical trials regarding the effect of resveratrol in decreasing the levels of inflammatory cytokines, including interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha in a combination of inflammatory diseases.	Resveratrol	114-125	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
34690948-12	2021	Serum IL-8 levels were significantly lower after FMT than at baseline, but IL-4, IL-6, IL-10, and IL-12p70 levels were not noticeably changed.	fmt	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
34638448-5	2021	Increasing levels of IL6, IL8, CXCL16, MPIF1, and YKL40 correlated with increasing levels of ceramide in both cohorts.	Ceramides	93-101	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
34289703-1	2021	OBJECTIVE: 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) imaging is thought to visualize active atherosclerotic plaque calcification.	18f-sodium fluoride	11-30	C-X-C motif chemokine ligand 8	Homo sapiens	36-39
34671275-13	2021	CXCL8, IL6, and IL1B were increased by the MRTF-SRF inhibitor CCG-1423 and by MRTF-A silencing in hCASMCs, but depolymerization of actin, known to inhibit MRTF activity, had no stimulatory effect, an exception being IL1B.	CCG 1423	62-70	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
34115201-10	2021	RESULTS: The dentifrices placebo and NaF in the low flow presented lower SMH and higher Ra in T3 and lower Ca% compared to the same dentifrices in normal flow.	Radium	88-90	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
34688464-5	2021	The results suggested that Neo decreased the levels of interleukin IL-1beta, IL-6, IL-8, TNF-alpha, MMP-3, MMP-9 and MMP-13 in FLSs.	neohesperidin	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
34115201-10	2021	RESULTS: The dentifrices placebo and NaF in the low flow presented lower SMH and higher Ra in T3 and lower Ca% compared to the same dentifrices in normal flow.	Triiodothyronine	94-96	C-X-C motif chemokine ligand 8	Homo sapiens	37-40
34308732-7	2021	Quercetin decreased the production of IL-1beta, IL-6, IL-8, TNF-alpha, iNOS, and COX-2, as well as signal transduction via the Akt/AMPK/mTOR pathway.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
34555226-3	2021	Prior studies indicated that IL-8-induced heterologous desensitization of the beta2-adrenergic receptor (beta2 -AR) led to decreased beta-agonist-induced mobilization of cyclic adenosine monophosphate (cAMP).	Adenosine	177-186	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
34555226-3	2021	Prior studies indicated that IL-8-induced heterologous desensitization of the beta2-adrenergic receptor (beta2 -AR) led to decreased beta-agonist-induced mobilization of cyclic adenosine monophosphate (cAMP).	Cyclic AMP	202-206	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
34189835-3	2021	Exposure to Pb nanoparticles for 24 h at a concentration of 100 mug/ml induced interleukin-8 (IL-8) expression in dTHP-1 cells.	Lead	12-14	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
34189835-3	2021	Exposure to Pb nanoparticles for 24 h at a concentration of 100 mug/ml induced interleukin-8 (IL-8) expression in dTHP-1 cells.	Lead	12-14	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
34615379-7	2021	PRO reduced the cytokine levels of TNF-alpha, IL-12 and IL-8 and inhibited tyrosinase.	Proline	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
34403670-5	2021	More interestingly, the higher MW digesta fraction containing the partially degraded EPS-LM showed even stronger inhibiting activity than the original EPS-LM on the LPS-induced pro-inflammatory responses in THP-1 cell culture, including NF-kappaB activation, release of NO, TNF-alpha and IL-8.	eps	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	288-292
34431007-4	2021	It was found that different concentrations of melatonin could significantly inhibit the expression levels of NFkappaB and its downstream cytokines, including IL6 and IL8 in Caco-2 cells (*P < 0.05, **P < 0.01), 3D intestinal organoids (*P < 0.05, **P < 0.01) and intestinal explants (*P < 0.05, **P < 0.01).	Melatonin	46-55	C-X-C motif chemokine ligand 8	Homo sapiens	166-169
34431007-5	2021	Melatonin abolished the activation of LPS on the expression levels of NFkappaB, IL6, and IL8 in three intestinal models (*P < 0.05, **P < 0.01, ***P < 0.001).	Melatonin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	89-92
34143519-9	2021	We also found significant changes in the cytokine profile after radioiodine ablation, including the decrease of tumor necrosis factor-alpha and IL-8 (P < 0.001, P < 0.001, respectively), and increase of IL-2R (P < 0.001).	Iodine-131	64-75	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
34398388-4	2021	BBB integrity and function were assessed via transendothelial electrical resistance (TEER) and paracellular flux of sodium fluorescein (NaF, 376 Da).	Fluorescein	116-134	C-X-C motif chemokine ligand 8	Homo sapiens	136-139
34514543-10	2021	Conversely, alpha7 nAChR-specific agonist GTS-21 diminished the release of interleukin-1beta (IL-1beta), IL-6, IL-8, and tumor necrosis factor-alpha (TNFalpha) in SH-SY5Y cells under inflammatory conditions.	3-(2,4-dimethoxybenzylidene)anabaseine	42-48	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
34601834-11	2021	CONCLUSION: Sodium fluoride (NaF) should be used as preservative to avoid ethanol neo-genesis during storage and transportation of blood samples for alcohol analysis.	Sodium Fluoride	12-27	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
34601834-11	2021	CONCLUSION: Sodium fluoride (NaF) should be used as preservative to avoid ethanol neo-genesis during storage and transportation of blood samples for alcohol analysis.	Ethanol	74-81	C-X-C motif chemokine ligand 8	Homo sapiens	29-32
34127514-6	2021	Compared with the non-IPA group, the proven/probable IPA group showed significantly elevated levels of IL-6 and IL-8 in both serum and BALF, which were positively correlated with galactomannan levels.	galactomannan	179-192	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
34638857-8	2021	Furthermore, IL-8/MCP-1 mRNA/protein was amplified in monocytic cells following stimulation with TNF-alpha in the presence of H2O2 or hypoxia (p   0.0001).	Hydrogen Peroxide	126-130	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
34333067-3	2021	A 24 hour exposure increased IL-8 release at an SDS concentration >=0.63 mM (0.018%, w/v).	Sodium Dodecyl Sulfate	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	29-33
34151709-6	2021	We showed that sodium fluoride (NaF) reduces cell viability in a concentration-dependent manner (p < 0.05) up to a 96-h time-point when compared to control.	Sodium Fluoride	15-30	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
34216363-11	2021	Secondly, the excessive production of inflammatory factors (IL-1beta, IL-8, and MCP-1) and adhesion molecules (ICAM-1 and VCAM-1) triggered by propofol was pronouncedly inhibited by Benzbromarone.	Propofol	143-151	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
34216363-11	2021	Secondly, the excessive production of inflammatory factors (IL-1beta, IL-8, and MCP-1) and adhesion molecules (ICAM-1 and VCAM-1) triggered by propofol was pronouncedly inhibited by Benzbromarone.	Benzbromarone	182-195	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
34603464-0	2021	Polyphyllin I Inhibits Propionibacterium acnes-Induced IL-8 Secretion in HaCaT Cells by Downregulating the CD36/NOX1/ROS/NLRP3/IL-1beta Pathway.	polyphyllin I	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
34468398-9	2021	TSH levels were inversely correlated with IL-8 (r = -0.248), IL-10 (r = -0.253), IL-15 (r = -0.213), IP-10 (r = -0.334) and GM-CSF (r = -0.254).	Thyrotropin	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
34584119-8	2021	Moreover, metformin also triggered mRNA expression of the proinflammatory cytokines IL1B, CXCL8 and growth factor GDF15 in human uroepithelial cells.	Metformin	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	90-95
34231590-7	2021	Our work confirms that Na3FeF6 undergoes conversion into NaF and Fe(s) nanoparticles.	na3fef6	23-30	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
34611474-8	2021	Treatment with Imipridones decreased CCL3/MIP-1 alpha, VEGF, CXCL14/BRAK, IL-8/CXCL8, and Prolactin and increased CXCL5/ENA-78.	imipridones	15-26	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
34611474-8	2021	Treatment with Imipridones decreased CCL3/MIP-1 alpha, VEGF, CXCL14/BRAK, IL-8/CXCL8, and Prolactin and increased CXCL5/ENA-78.	imipridones	15-26	C-X-C motif chemokine ligand 8	Homo sapiens	79-84
34611476-9	2021	There was an increase in IL-8 by oxaliplatin and increase in ferritin by cisplatin which may contribute to cancer cell survival.	Oxaliplatin	33-44	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
34603464-4	2021	Reactive oxygen species (ROS) acts as a trigger for the production of IL-8 and activates theNLRP3 inflammasome.	Reactive Oxygen Species	0-23	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
34603464-4	2021	Reactive oxygen species (ROS) acts as a trigger for the production of IL-8 and activates theNLRP3 inflammasome.	Reactive Oxygen Species	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
34355225-7	2021	The interleukin (IL)-1beta-induced release of inflammatory cytokines IL-8 and tumor necrosis factor (TNF)-alpha in human chondrosarcoma cells was inhibited by monapurpureusone (8) and monascuspirolide B (14).	Monascuspirolide B	184-202	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
34355225-7	2021	The interleukin (IL)-1beta-induced release of inflammatory cytokines IL-8 and tumor necrosis factor (TNF)-alpha in human chondrosarcoma cells was inhibited by monapurpureusone (8) and monascuspirolide B (14).	monapurpureusone	159-175	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
34536415-8	2022	RESULTS: Mutant HCK lacking the C-terminal inhibitory tyrosine Tyr522 exhibited increased kinase activity and enhanced myeloid cell priming, migration and effector functions, such as production of the inflammatory cytokines IL-1beta, IL-6, IL-8 and TNFalpha and production of reactive oxygen species.	Tyrosine	54-62	C-X-C motif chemokine ligand 8	Homo sapiens	240-244
34632188-7	2021	Furthermore, 1,4-naphthoquinone potently suppressed the production and secretion of key proinflammatory cytokine proteins IL-8, IL-1beta, IL-10, TNF-alpha, and IL-6 in LPS-stimulated PMA-induced human THP-1 macrophages.	1,4-naphthoquinone	13-31	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
34579097-7	2021	For metabolic and inflammatory factors, the participants in the CR-RS group showed significant decreases in low density lipoprotein cholesterol (-0.40 mmol/L) and interleukin-8 (-0.73 mmol/L).	cr-rs	64-69	C-X-C motif chemokine ligand 8	Homo sapiens	163-176
34519008-1	2021	BACKGROUND: While (18F)-fluordeoxyglucose ((18F)FDG) uptake is associated with arterial inflammation, (18F)-sodium fluoride ((18F)NaF) is a marker for arterial micro-calcification.	(18f)-sodium fluoride	102-123	C-X-C motif chemokine ligand 8	Homo sapiens	130-133
34524489-4	2022	18F-sodium fluoride (NaF) PET/CT is an excellent bone-seeking agent superior to conventional bone scan in CKD patients due to its high bone uptake, rapid single-pass extraction, and minimal binding to serum proteins.	18f-sodium fluoride	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
34493652-3	2021	We demonstrate that selective zwitterion-anion interactions simultaneously control salt partitioning and diffusivity, with the permeabilities of NaClO4, NaI, NaBr, NaCl, NaF, and Na2SO4 spanning roughly three orders of magnitude over a wide range of feed concentrations.	Anions	41-46	C-X-C motif chemokine ligand 8	Homo sapiens	170-173
34493652-3	2021	We demonstrate that selective zwitterion-anion interactions simultaneously control salt partitioning and diffusivity, with the permeabilities of NaClO4, NaI, NaBr, NaCl, NaF, and Na2SO4 spanning roughly three orders of magnitude over a wide range of feed concentrations.	Salts	83-87	C-X-C motif chemokine ligand 8	Homo sapiens	170-173
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	Quercetin	101-110	C-X-C motif chemokine ligand 8	Homo sapiens	236-241
34495872-7	2021	Administration of IPI504 at 0.5-5 muM can significantly inhibit the induction of IL-1beta, IL-6, IL-8, MCP-1 and VEGFA in senescent ARPE-19 and the senescence-mediated migration of retinal capillary endothelial cells in vitro.	tanespimycin	18-24	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
34568366-5	2021	Results: IL-6, IL-8, IP-10, and MCP-1 in aqueous humor of DME vitrectomized eyes were significantly higher than in non-vitrectomized DME eyes, while VEGF was lower than in non-vitrectomized DME eyes.	dme	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	hederagenin	133-144	C-X-C motif chemokine ligand 8	Homo sapiens	236-241
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	shionone	146-154	C-X-C motif chemokine ligand 8	Homo sapiens	236-241
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	kaempferol	159-169	C-X-C motif chemokine ligand 8	Homo sapiens	236-241
34572676-5	2021	The biomedical field has the highest need of AMPs as it possesses prominent desirable activity against HIV-1, skin cancer, breast cancer, in Behcet"s disease treatment, as well as in reducing the release of inflammatory cells such as TNFalpha, IL-8, and IL-1beta, enhancing the production of anti-inflammatory cytokines such as IL-10 and GM-CSF, and in wound healing properties.	Adenylyl sulfate	45-49	C-X-C motif chemokine ligand 8	Homo sapiens	244-248
34566947-12	2021	Protease allergen of nTyr-p3 significantly increased the levels of pro-inflammatory cytokines (IL-6 and TNF-alpha), chemokine (IL-8), and IL-1beta in epithelial cells.	ntyr-p3	21-28	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
34566947-17	2021	Among the pharmacologic inhibitors, the most effective inhibitor of the nTyr-p3 in the induction of IL-8 or IL-1beta levels was GB88 followed by SBTI, MAPK/ERK, ERK, and p38 inhibitors.	ntyr-p3	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
34566947-17	2021	Among the pharmacologic inhibitors, the most effective inhibitor of the nTyr-p3 in the induction of IL-8 or IL-1beta levels was GB88 followed by SBTI, MAPK/ERK, ERK, and p38 inhibitors.	GB88	128-132	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	Luteolin	112-120	C-X-C motif chemokine ligand 8	Homo sapiens	236-241
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	Berberine	122-131	C-X-C motif chemokine ligand 8	Homo sapiens	236-241
34572313-12	2021	In conclusion, we discovered that cross-talk between FcgammaRIII engagement-induced Syk-ERK and PMA-induced PKC signaling pathways augment NET formation of dHL-60 via increased ROS generation and pro-inflammatory cytokines, IL-8 and TNF-alpha, production.	Tetradecanoylphorbol Acetate	96-99	C-X-C motif chemokine ligand 8	Homo sapiens	224-228
34557089-0	2021	Platinum Accumulation and Cancer-Related Fatigue, Correlation With IL-8, TNF-alpha and Hemocytes.	Platinum	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
34557089-7	2021	Mediating effect analysis showed that increased IL-8 concentration mediated 57.4%, while decreased erythrocyte count mediated 24.1% of the C-Pt effect on CRF.	c-pt	139-143	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
34557089-8	2021	Platinum accumulation may involve increasing IL-8, cause inflammation or aggravate anemia, which in combination lead to CRF.	Platinum	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
34573967-6	2021	The serum IL-8 and TNF-alpha concentration measured in the OC Group was significantly higher than in the BOC Group (p < 0.05).	boc	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
34482382-3	2021	By analyzing transcriptome of enzalutamide-resistant prostate cancer cells, we found that resistance was conferred by a mild caspase-8 upregulation that in turn led to NF-kappaB activation and the subsequent upregulation of the downstream IL-8.	enzalutamide	30-42	C-X-C motif chemokine ligand 8	Homo sapiens	239-243
34482382-7	2021	Collectively, our work demonstrates that enzalutamide-resistance is mediated by caspase-8 upregulation and the consequent increase in NF-kappaB/IL-8 mediated survival signaling, highlighting caspase-8 and NF-kappaB as potential therapeutic targets to overcome enzalutamide-resistance in CRPC.	enzalutamide	41-53	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
34080770-7	2021	Meanwhile, we demonstrated that miR-486-3p regulates NaF-induced upregulation of CyclinD1 by directly targeting its 3"-untranslated region (3"-UTR).	p-Bis(2-chloroethyl)amino-o-methoxyphenylalanine	40-42	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
34280354-5	2021	In addition, the expression of various genes involved in carcinogenesis, namely, NFE2L2 (antioxidative response), CXCL8 (inflammation), CDH1 (cell adhesion), MMP9 (tissue remodeling) and MKI67 (cell proliferation) were altered in cholangiocytes treated with DCM.	Methylene Chloride	258-261	C-X-C motif chemokine ligand 8	Homo sapiens	114-119
34280354-7	2021	In malignant cell lines (HuCCA-1 and RMCCA-1), DCM treatment resulted in increased CXCL8 and MMP9 transcription and decreased CDH1 transcription accompanied by increased invasion and migration capabilities of these cells.	Methylene Chloride	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	83-88
34080770-6	2021	Further, we verified that sodium fluoride (NaF) decreases miR-486-3p expression in human osteoblasts and overexpression of miR-486-3p reduces fluoride-induced osteoblast proliferation and activation.	Sodium Fluoride	26-41	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
34412775-9	2021	The fluorine mainly as the formation of substantial NaF and CaF2 in the residual ash.	Fluorine	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
34080770-6	2021	Further, we verified that sodium fluoride (NaF) decreases miR-486-3p expression in human osteoblasts and overexpression of miR-486-3p reduces fluoride-induced osteoblast proliferation and activation.	Fluorides	142-150	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
34080770-7	2021	Meanwhile, we demonstrated that miR-486-3p regulates NaF-induced upregulation of CyclinD1 by directly targeting its 3"-untranslated region (3"-UTR).	mir-486	32-39	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
34610759-3	2021	Results: MiR-101-3p was increased in the NS patients and the dysregulation of miR-101-3p was associated with levels of procalcitonin, CRP, IL-8 and TNF-alpha.	mir-101-3p	78-88	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
34610759-5	2021	The silenced miR-101-3p reversed the increased levels of TNF-alpha and IL-8 caused by lipopolysaccharide in vitro.	mir-101-3p	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
34502382-10	2021	These results suggest that PAI-1 and IL-8 produced by OSCC contribute to the differentiation of monocytes to CD206+ TAMs.	tams	116-120	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
34497153-9	2021	IPA analysis revealed ibuprofen having modulating effects on inflammation-related pathways such as integrin, IL-8, ERK/MAPK and cAMP-mediated signalling pathways.	Ibuprofen	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
34252445-3	2021	Based on our experimental data, 24 hours after treatment with fusarotoxins, hydrogen peroxide levels, intracellular oxidative stress and the amounts of inflammatory interleukins IL-6 and IL-8 significantly increased.	fusarotoxins	62-74	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
34512648-8	2021	In preterm infants, exposure to HCA was associated with elevations in 8 immune proteins on postnatal day 5 (BDNF, C3, C5a, C9, IL-8, MCP-1, MIP-1beta and MMP-9) when compared to preterm infants who were not exposed.	hca	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
34415898-9	2021	Overall, IL-4 levels did not change significantly over time in either group; however, patients within the CE3b group showed a significant decrease of IL-1ra, IL-6, IL-8, G-CSF, IFN-gamma, IP-10, MCP-1, MIP-1alpha, FGF at T1 compared to T0 (p<=0.042).	ce3b	106-110	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
34513587-7	2021	In this article we intend to present different patterns of OA (mild to severe stages of OA) that we had observed on 18F-Sodium Fluoride (18F-NaF) PET/MRI.	18f-sodium fluoride	116-135	C-X-C motif chemokine ligand 8	Homo sapiens	141-144
34426617-4	2021	The DMEK group exhibited significantly lower concentrations of several pro-inflammatory cytokines, such as IL-1beta, IL-5, IL-6, IL-10, and IL-8, and granulocyte colony stimulating factor than the BK group.	dmek	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
34504537-8	2021	EFE inhibited the expression of MMP-1, MMP-3, and proinflammatory cytokines (TNF-alpha, IL-6, and IL-8) in IL-1beta-stimulated HGFs through the inhibition of IL-1beta-induced MAPK/STAT-3 activation.	EFE	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
34412678-10	2021	In addition, we discovered that ASFV infection is involved in the regulation of chemokine expression in PAMs, and the chemokines, such as C-X-C motif chemokine 8 (CXCL8) and CXCL10, were upregulated after infection.	c-x-c	138-143	C-X-C motif chemokine ligand 8	Homo sapiens	163-168
34497913-3	2021	The significant amplifying actions of two PAHs, dibenzo(a,l)pyrene (DB(a,l)P) at 50 nM and dibenzo(a,i)pyrene (DB(a,i)P) at 2 muM for 48 h, for IL-8 protein release induced by mite antigens in epithelial cells were observed for the first time.	dibenzo(a,l)pyrene	48-66	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
34497913-3	2021	The significant amplifying actions of two PAHs, dibenzo(a,l)pyrene (DB(a,l)P) at 50 nM and dibenzo(a,i)pyrene (DB(a,i)P) at 2 muM for 48 h, for IL-8 protein release induced by mite antigens in epithelial cells were observed for the first time.	dibenzo(a,l)pyrene	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
34497913-3	2021	The significant amplifying actions of two PAHs, dibenzo(a,l)pyrene (DB(a,l)P) at 50 nM and dibenzo(a,i)pyrene (DB(a,i)P) at 2 muM for 48 h, for IL-8 protein release induced by mite antigens in epithelial cells were observed for the first time.	dibenzo(a,i)pyrene	91-109	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
34497913-3	2021	The significant amplifying actions of two PAHs, dibenzo(a,l)pyrene (DB(a,l)P) at 50 nM and dibenzo(a,i)pyrene (DB(a,i)P) at 2 muM for 48 h, for IL-8 protein release induced by mite antigens in epithelial cells were observed for the first time.	dibenzo(a,i)pyrene	111-119	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
34445582-6	2021	An experiment with an antibody array for 25 angiogenesis-related proteins revealed that only interleukin-8 expression was significantly upregulated in HUVECs treated with ADSC-LPS-exo.	adsc-lps	171-179	C-X-C motif chemokine ligand 8	Homo sapiens	93-106
34445558-11	2021	The conditioned medium obtained from IronQ-treated PBMCs contained high levels of interleukin 8 (IL-8), IL-10, urokinase-type-plasminogen-activator (uPA), matrix metalloproteinases-9 (MMP-9), and tumor necrosis factor-alpha (TNF-alpha), as well as augmented migration and capillary network formation of HUVECs and fibroblast cells, in vitro.	ironq	37-42	C-X-C motif chemokine ligand 8	Homo sapiens	82-95
34445558-11	2021	The conditioned medium obtained from IronQ-treated PBMCs contained high levels of interleukin 8 (IL-8), IL-10, urokinase-type-plasminogen-activator (uPA), matrix metalloproteinases-9 (MMP-9), and tumor necrosis factor-alpha (TNF-alpha), as well as augmented migration and capillary network formation of HUVECs and fibroblast cells, in vitro.	ironq	37-42	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
34445390-6	2021	LPS-induced activation of NFAT-regulated cytokines (IL-6 and IL-8) is inhibited by treatment of cells with VIVIT.	NFAT Inhibitor	107-112	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
34429629-11	2021	In DNPCs, ATP and IL-1alpha induced the expression of IL-8 and CXCL-1.	Adenosine Triphosphate	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
34441355-2	2021	With regard to tracer, there has been a shift from using mainly 18F-fluorodeoxyglucose (FDG), indicating inflammation, to applying predominantly 18F-sodium fluoride (NaF) due to its high affinity for arterial wall microcalcification and more consistent association with cardiovascular risk factors.	18f-sodium fluoride	145-164	C-X-C motif chemokine ligand 8	Homo sapiens	166-169
34452455-7	2021	When the models were challenged with a combination of the bacterial toxins LPS and ATP, a release of the proinflammatory cytokines IL-1beta and IL-8 was observed, confirming that the model can generate an immune response.	Adenosine Triphosphate	83-86	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
34286584-0	2021	Nanoparticles for Directed Immunomodulation: Mannose-Functionalized Glycodendrimers Induce Interleukin-8 in Myeloid Cell Lines.	Mannose	45-52	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
34286584-3	2021	This design enhanced glycodendrimer bioactivity and led to complex functional effects in myeloid cells, with specific induction of interleukin-8 expression by mannose glycodendrimers detected in HL-60 and THP-1 cells.	mannose glycodendrimers	159-182	C-X-C motif chemokine ligand 8	Homo sapiens	131-144
34363384-8	2021	Knockdown of IL-8 abolished Lefty-regulated sunitinib sensitivity of RCC cells.	Sunitinib	44-53	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
34318676-0	2021	Experimental and Computational Exploration of the NaF-ThF4 Fuel System: Structure and Thermochemistry.	thf4	54-58	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
34443321-3	2021	The effect of BBR on AA/LPS activated proinflammatory markers including TNF-alpha, MCP-1, IL-8 and COX-2 was measured by ELISA or quantitative real-time PCR.	Berberine	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
34318676-3	2021	The phase equilibria in the 10-50 mol % ThF4 and 85-95 mol % ThF4 regions of the NaF-ThF4 phase diagram were measured using differential scanning calorimetry, as were the mixing enthalpies at 1266 K of (NaF/ThF4) = (0.8:0.2), (0.7:0.3) mixtures.	thf4	61-65	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
34318676-3	2021	The phase equilibria in the 10-50 mol % ThF4 and 85-95 mol % ThF4 regions of the NaF-ThF4 phase diagram were measured using differential scanning calorimetry, as were the mixing enthalpies at 1266 K of (NaF/ThF4) = (0.8:0.2), (0.7:0.3) mixtures.	thf4	85-89	C-X-C motif chemokine ligand 8	Homo sapiens	81-84
34443321-5	2021	AA/ LPS-induced TNF-alpha, MCP-1, IL-6, IL-8, and COX-2 markers were markedly attenuated by BBR treatment in THP-1 cells by inhibiting NF-kappaB translocation into the nucleus.	Berberine	92-95	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
34229236-8	2021	Present article highlights new mechanistic insights through which DMB inhibits ROS/RNS, oxidative stress, mitochondrial dysfunctions and neuroinflammation such as NFkappaB, TNF-alpha, IL-6 and IL-8, cytokinin.	demethyleneberberine	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
34348775-1	2021	BACKGROUND: Silver diamine fluoride (SDF) and sodium fluoride (NaF) are widely used for caries management.	Sodium Fluoride	46-61	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
34424286-6	2021	Results: In the MDR-PA group, significantly (P < 0.05) increased expression of IL-6, IL-8, IL-10, IL-1beta, and TNF-alpha was observed in comparison with the S-PA group.	mdr-pa	16-22	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
34424286-6	2021	Results: In the MDR-PA group, significantly (P < 0.05) increased expression of IL-6, IL-8, IL-10, IL-1beta, and TNF-alpha was observed in comparison with the S-PA group.	s-pa	158-162	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
34372688-10	2021	IL-1beta-induced inflammation, assessed by IL-1beta, IL-8, and tumour necrosis factor alpha (TNF-alpha) upregulation, was alleviated by suramin treatment.	Suramin	136-143	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
34459125-8	2021	Subsequently, TNF-alpha, IL-1beta, and lactate activated CAFs, and facilitated the secretion of IL-6, IL-7, IL-8, CCL5, and transforming growth factor-beta1 from CAFs.	Lactic Acid	39-46	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
34241784-4	2021	Characellide A induces a concentration- and time-dependent CXCL8, IL-6 and TNF-alpha release from PBMC.	characellide a	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	59-64
34097917-6	2021	RESULTS: IL-8 urinary levels were increased in patients with T2D and diabetic kidney disease, with the highest urinary IL-8 levels found in the patients with the largest decline in glomerular filtration rate, with an increased albumin/creatine ratio and the worst renal outcome.	Creatine	235-243	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
34097917-8	2021	High glucose elicits abundant IL-8 secretion in cultured human immortalized podocytes in vitro.	Glucose	5-12	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
34439789-6	2021	Significant correlations were found with PHE volume for IL-6, IL-10 and CCL2 at day 1-2 and with relative PHE at days 7-8 or 9-10 for IL-1beta, IL-6, IL-8, and IL-10.	Phenylalanine	106-109	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
34355287-8	2021	Moreover, BDMC-A treatment downregulated MMP-9, VEGF, TGF- beta, IL-6 and IL-8 and upregulated TIMP-2 levels.	bdmc-a	10-16	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
34296555-8	2021	The concentrations of Cr, Ni, and Au ions in the saliva were positively correlated with IL-8.	Chromium	22-24	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
34296555-8	2021	The concentrations of Cr, Ni, and Au ions in the saliva were positively correlated with IL-8.	Gold	34-36	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
34296555-10	2021	CONCLUSION: Increased concentrations of metal ions, especially Ni, in saliva were positively correlated with IL-8 and showed positive correlations with the severity of OLL.	Metals	40-45	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
34361481-5	2021	MAO coatings were successfully prepared on the surface of Zn-Mn-Mg alloys by MAO in silicate-based solutions with different NaF concentrations.	5'-DEOXY-5'-[N-METHYL-N-(2-AMINOOXYETHYL) AMINO]ADENOSINE	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	124-127
34361481-5	2021	MAO coatings were successfully prepared on the surface of Zn-Mn-Mg alloys by MAO in silicate-based solutions with different NaF concentrations.	zn-mn	58-63	C-X-C motif chemokine ligand 8	Homo sapiens	124-127
34361481-6	2021	The microstructure and phase composition of MAO coatings prepared on Zn-Mn-Mg alloys with different NaF concentrations in the electrolyte was examined by a scanning electron microscope and X-ray diffraction.	5'-DEOXY-5'-[N-METHYL-N-(2-AMINOOXYETHYL) AMINO]ADENOSINE	44-47	C-X-C motif chemokine ligand 8	Homo sapiens	100-103
34361481-11	2021	The highest corrosion rate can be achieved after MAO treatment, with an electrolyte concentration of 1.5 g/L NaF in Hank"s solution.	5'-DEOXY-5'-[N-METHYL-N-(2-AMINOOXYETHYL) AMINO]ADENOSINE	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	109-112
34110092-7	2021	Our findings suggest that p-gliadin composed of supramolecular structures triggers significant mRNA up-regulation (p < 0.05) of pro-apoptotic biomarkers (ratio Bcl2/Bak-1), chemokines (CCL2, CCL3, CCL4, CCL5, CXCL8) and the chemokine receptor CXCR3.	p-gliadin	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	209-214
34250537-0	2021	Stabilizing Na metal anode with NaF interface on spent cathode carbon from aluminum electrolysis.	Carbon	63-69	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
34361481-11	2021	The highest corrosion rate can be achieved after MAO treatment, with an electrolyte concentration of 1.5 g/L NaF in Hank"s solution.	hank"s solution	116-131	C-X-C motif chemokine ligand 8	Homo sapiens	109-112
34250537-0	2021	Stabilizing Na metal anode with NaF interface on spent cathode carbon from aluminum electrolysis.	Aluminum	75-83	C-X-C motif chemokine ligand 8	Homo sapiens	32-35
34250537-1	2021	We report the synthesis of spent cathode carbon (SCC) with a NaF interface from aluminum electrolysis, and its application as a Na metal anode host.	Carbon	41-47	C-X-C motif chemokine ligand 8	Homo sapiens	61-64
34250537-1	2021	We report the synthesis of spent cathode carbon (SCC) with a NaF interface from aluminum electrolysis, and its application as a Na metal anode host.	Aluminum	80-88	C-X-C motif chemokine ligand 8	Homo sapiens	61-64
34368356-10	2021	NaF is effective in enhancing the enamel/dentin bond durability and also helps create a high quality of ARBZ to improve the clinical success of restorations.	arbz	104-108	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
34438645-6	2021	Proteomics analysis of cytokines showed that niacin supplementation increased the expression of duodenal transforming growth factor-beta (TGF-beta), jejunal interleukin-10 (IL-10) and ileal interleukin-6 (IL-6) (p < 0.05), and reduced the expression of ileal interleukin-8 (IL-8) (p < 0.05) compared with the control diet.	Niacin	45-51	C-X-C motif chemokine ligand 8	Homo sapiens	253-272
34438645-6	2021	Proteomics analysis of cytokines showed that niacin supplementation increased the expression of duodenal transforming growth factor-beta (TGF-beta), jejunal interleukin-10 (IL-10) and ileal interleukin-6 (IL-6) (p < 0.05), and reduced the expression of ileal interleukin-8 (IL-8) (p < 0.05) compared with the control diet.	Niacin	45-51	C-X-C motif chemokine ligand 8	Homo sapiens	274-278
34439757-6	2021	Additionally, the RA-RF significantly reduced ROS production, IL-6, IL-8, TNF-alpha, and COX-2.	rosmarinic acid	18-20	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
34369925-6	2021	Similar percent drops in metabolic activity of the iHCEC and pHCEC occurred after exposure to BAK, H2O2, or SDS, and the most significant changes in cytokine release occurred for IL-6 and IL-8.	Hydrogen Peroxide	99-103	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
34292876-7	2021	Agomelatine also suppressed the expression of TNF-alpha, IL-8, and IL-12, which are proinflammatory cytokines that promote endothelial dysfunction and atherogenesis.	agomelatine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
34350063-4	2021	Alternol triggered ICD in prostate cancer cells, as evidenced by the release of damage-associated molecular patterns (DAMPs) (i.e., calreticulin, CALR; high mobility group protein B1, HMGB1; and adenosine triphosphate, ATP) and pro-inflammatory cytokine (i.e., interleukin (IL)-1alpha, IL-1beta, IL-6, and IL-8) expression.	Alternol	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	306-310
34371919-6	2021	We showed that although TNF-alpha secretion was downregulated in both LPS-activated MPhi subtypes by caffeine, the secretion of IL-8, IL-6, and IL-1beta as well as the expression of Nod-like receptors was enhanced in M-MPhis, while it did not change in GM-MPhis.	Caffeine	101-109	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
34280220-3	2021	TG6-44 significantly decreased A/X31-induced ROS and virus-induced inflammatory mediators in THP-1 cells (IL-6, IFN-gamma, MCP-1, TNF-alpha, MIP-1beta) and in human PBMC (IL-6, IL-8, TNF-alpha, MCP-1).	6-O-phosphono-D-tagatose	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
34299258-5	2021	Resveratrol inhibited degranulation and expression of cytokines and chemokines such as CXCL8, CCL2, CCL3, CCL4, and TNF-alpha in a dose-dependent manner.	Resveratrol	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	87-92
34281061-3	2021	In monocytes/macrophages, vitamin D suppresses the production of the inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-8.	Vitamin D	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
34299030-8	2021	TNFalpha stimulated the cytokine expression in FLS, and NDMVs down-regulated TNFalpha-induced expression of IL-5, IL-6, IL-8, MCP-1, IFNgamma and MIP-1beta.	ndmvs	56-61	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
34305638-16	2021	During alcohol detoxification, LS, transaminases, TGF- beta, IL-6, IL-8 and VEGF decreased significantly.	Alcohols	7-14	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
34262692-11	2021	Interleukin (IL)-8, IL-10, IL-1alpha, and tissue inhibitor of metalloproteinase (TIMP)-1 concentrations were significantly increased in the culture medium of cells exposed to PM2.5, and budesonide significantly reduced the changes in IL-8, IL-1alpha, and TIMP-1.	Budesonide	186-196	C-X-C motif chemokine ligand 8	Homo sapiens	0-18
34262692-11	2021	Interleukin (IL)-8, IL-10, IL-1alpha, and tissue inhibitor of metalloproteinase (TIMP)-1 concentrations were significantly increased in the culture medium of cells exposed to PM2.5, and budesonide significantly reduced the changes in IL-8, IL-1alpha, and TIMP-1.	Budesonide	186-196	C-X-C motif chemokine ligand 8	Homo sapiens	234-238
34114792-7	2021	Markedly, NCO-sP(EO-stat-PO)-rich samples induced a significantly reduced release of proinflammatory cytokines, IL-1beta, IL-6, and IL-8.	nco-sp	10-16	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
34114792-7	2021	Markedly, NCO-sP(EO-stat-PO)-rich samples induced a significantly reduced release of proinflammatory cytokines, IL-1beta, IL-6, and IL-8.	eo-stat-po	17-27	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
34152720-5	2021	Our results demonstrated that treatment with baicalein protects T98G cells from H2O2-induced damage, delays cell senescence, inhibits the secretion of SASP (IL-6, IL-8, TNF-alpha, CXCL1, and MMP-1), and inhibits SASP-related pathways NF-kappaB and JAK2/STAT1.	baicalein	45-54	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
34227646-3	2021	It was observed that the expression of IL-1beta, IL-6, IL-8 and TNFalpha in LPS-induced HGFs was significantly downregulated by RSV in a dose-dependent manner.	Resveratrol	128-131	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
34227646-6	2021	Subsequently, it was demonstrated treatment with PI3K/AKT pathway inhibitor (LY294002) or Wnt/beta-catenin pathway inhibitor (Dickkopf-1, DKK-1) could further enhance the anti-inflammatory and antioxidant effects of RSV by downregulating the expression of IL-1beta, IL-6, IL-8 and TNFalpha, and the production of MDA, and increasing the activity of SOD and GSH-Px in LPS-induced HGFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	272-276
34227646-6	2021	Subsequently, it was demonstrated treatment with PI3K/AKT pathway inhibitor (LY294002) or Wnt/beta-catenin pathway inhibitor (Dickkopf-1, DKK-1) could further enhance the anti-inflammatory and antioxidant effects of RSV by downregulating the expression of IL-1beta, IL-6, IL-8 and TNFalpha, and the production of MDA, and increasing the activity of SOD and GSH-Px in LPS-induced HGFs.	Resveratrol	216-219	C-X-C motif chemokine ligand 8	Homo sapiens	272-276
34414894-6	2021	Budesonide reduced synthesis of interleukin 4 (IL-4), CXCL8, tumor necrosis factor alpha (TNFalpha) by NK and NKT-like cells, as well as production of interferon gamma (IFNgamma) by NK cells.	Budesonide	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	54-59
34787252-2	2021	The specimens were exposed to mesoporous silica (MS) nanocomposites containing fluoride by association with titanium tetrafluoride (TiF4) or sodium fluoride (NaF).	Sodium Fluoride	141-156	C-X-C motif chemokine ligand 8	Homo sapiens	158-161
34222847-10	2021	A decrease from baseline was higher in the NTZ group for d-Dimer (p = 0.001), US-RCP (p < 0.002), TNF (p < 0.038), IL-6 (p < 0.001), IL-8 (p = 0.014), HLA DR. on CD4+ T lymphocytes (p < 0.05), CD38 in CD4+ and CD8+ T (both p < 0.05), and CD38 and HLA-DR. on CD4+ (p < 0.01).	nitazoxanide	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
34277625-4	2021	Here, we show that IL-8 secreted from CAFs could activate normal ovarian fibroblasts (NFs) through multiple signaling and that IL-8 stimulated malignant growth of ovarian cancer cells in animals and increased the IC50 of cisplatin (CDDP) in ovarian cancer cells.	Cisplatin	221-230	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
34277625-4	2021	Here, we show that IL-8 secreted from CAFs could activate normal ovarian fibroblasts (NFs) through multiple signaling and that IL-8 stimulated malignant growth of ovarian cancer cells in animals and increased the IC50 of cisplatin (CDDP) in ovarian cancer cells.	Cisplatin	221-230	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
34277625-4	2021	Here, we show that IL-8 secreted from CAFs could activate normal ovarian fibroblasts (NFs) through multiple signaling and that IL-8 stimulated malignant growth of ovarian cancer cells in animals and increased the IC50 of cisplatin (CDDP) in ovarian cancer cells.	Cisplatin	232-236	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
34277625-4	2021	Here, we show that IL-8 secreted from CAFs could activate normal ovarian fibroblasts (NFs) through multiple signaling and that IL-8 stimulated malignant growth of ovarian cancer cells in animals and increased the IC50 of cisplatin (CDDP) in ovarian cancer cells.	Cisplatin	232-236	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
34414894-8	2021	The combination of azithromycin and budesonide had a more pronounced inhibitory effect on the production of IL-4 and CXCL8 by NK and NKT-like cells than the effect of these drugs alone.	Azithromycin	19-31	C-X-C motif chemokine ligand 8	Homo sapiens	117-122
34414894-7	2021	Azithromycin suppressed production of IL-4 and CXCL8 by NK and NKT-like cells, and theophylline inhibited IL-4 synthesis by these lymphocytes.	Azithromycin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	47-52
34414894-8	2021	The combination of azithromycin and budesonide had a more pronounced inhibitory effect on the production of IL-4 and CXCL8 by NK and NKT-like cells than the effect of these drugs alone.	Budesonide	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	117-122
34414894-9	2021	The combination of theophylline and budesonide suppressed synthesis of IL-4 and CXCL8 by NK and NKT-like cells, as well as the production of TNFalpha and IFNgamma by NK cells stronger than budesonide alone.	Theophylline	19-31	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
34203170-3	2021	We observed the secretion of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and IL-8 by treating FLA-AA to human dermal fibroblasts, as well as macrophages.	fla-aa	142-148	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
34414894-9	2021	The combination of theophylline and budesonide suppressed synthesis of IL-4 and CXCL8 by NK and NKT-like cells, as well as the production of TNFalpha and IFNgamma by NK cells stronger than budesonide alone.	Budesonide	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
34106680-0	2021	Mid-Infrared Luminescence of the High Stability Perovskite CsPb1-xErxBr3-ZrF4-BaF2-LaF3-AlF3-NaF Fluoride Glass.	Fluorides	97-105	C-X-C motif chemokine ligand 8	Homo sapiens	93-96
34212232-1	2021	This study aimed to formulate a hybrid coating material (HC) and to modify this HC with fluoride (NaF) and stannous (SnCl2) ions, directly or encapsulated in nano containers, testing the effects of these materials against dental erosion and erosion-abrasion.	Fluorides	88-96	C-X-C motif chemokine ligand 8	Homo sapiens	98-101
34372493-6	2021	Plasma IL-8, Ccl2, VEGF, and 8-isoprostane loaded onto one factor that was highest in the HIV+/METH+ group (p < 0.047) reflecting worse inflammation, vascular injury, and oxidative stress.	Methamphetamine	95-99	C-X-C motif chemokine ligand 8	Homo sapiens	7-11
34234508-10	2021	Conclusion: We found that metabolites in phospholipid groups had strong associations with multiple inflammatory biomarkers, especially CRP, SAA and IL-8.	Phospholipids	41-53	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
34199005-11	2021	In contrast, an inflammatory response in A549 cells was more evident after exposure toward aerosols of nano-scaled filler combustion, whereas the thermal decomposition of PE-based materials revealed an impaired IL-8 secretion.	Polyethylene	171-173	C-X-C motif chemokine ligand 8	Homo sapiens	211-215
34168274-8	2021	The hub targets for aspirin in preventing preeclampsia were tumor protein p53 (TP53), C-X-C motif chemokine ligand 8 (CXCL8), mitogen-activated protein kinase 3 (MAPK3), mitogen-activated protein kinase 1 (MAPK1), mitogen-activated protein kinase 14 (MAPK14), epidermal growth factor receptor (EGFR), estrogen receptor (ESR1), and prostaglandin-endoperoxide synthase 2 (PTGS2).	Aspirin	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	86-116
34172787-9	2021	IL-8, alpha1AT, ferritin, CRP and LDH levels were higher in silicosis than in those exposed to silica without silicosis.	Silicon Dioxide	95-101	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
34168274-8	2021	The hub targets for aspirin in preventing preeclampsia were tumor protein p53 (TP53), C-X-C motif chemokine ligand 8 (CXCL8), mitogen-activated protein kinase 3 (MAPK3), mitogen-activated protein kinase 1 (MAPK1), mitogen-activated protein kinase 14 (MAPK14), epidermal growth factor receptor (EGFR), estrogen receptor (ESR1), and prostaglandin-endoperoxide synthase 2 (PTGS2).	Aspirin	20-27	C-X-C motif chemokine ligand 8	Homo sapiens	118-123
34284965-13	2022	CONCLUSION: Our work demonstrated that CXCL8 may be a potential molecule to be targeted for the treatment of PTX-resistant TNBC.	Paclitaxel	109-112	C-X-C motif chemokine ligand 8	Homo sapiens	39-44
34284965-0	2022	CXCL8 Facilitates the Survival and Paclitaxel-Resistance of Triple-Negative Breast Cancers.	Paclitaxel	35-45	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
34179086-5	2021	RT-qPCR was used to detect the mRNA expression of inflammatory cytokines (CCL2, IL-8, CCL4) and genes associated with angiogenesis (VEGF, ANG-1, ANG-2) in early EPCs after treatment of LPC (10 mug/ml) or phosphatidylcholine (PC, 10 mug/ml, control).	Lysophosphatidylcholines	185-188	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
34284965-1	2022	BACKGROUND: This study aimed to demonstrate CXCL8 expression in TNBC tissues and cells, and elucidate the functional mechanism of CXCL8 in paclitaxel (PTX)-resistant TNBC.	Paclitaxel	139-149	C-X-C motif chemokine ligand 8	Homo sapiens	44-49
34284965-1	2022	BACKGROUND: This study aimed to demonstrate CXCL8 expression in TNBC tissues and cells, and elucidate the functional mechanism of CXCL8 in paclitaxel (PTX)-resistant TNBC.	Paclitaxel	139-149	C-X-C motif chemokine ligand 8	Homo sapiens	130-135
34284965-1	2022	BACKGROUND: This study aimed to demonstrate CXCL8 expression in TNBC tissues and cells, and elucidate the functional mechanism of CXCL8 in paclitaxel (PTX)-resistant TNBC.	Paclitaxel	151-154	C-X-C motif chemokine ligand 8	Homo sapiens	44-49
34284965-1	2022	BACKGROUND: This study aimed to demonstrate CXCL8 expression in TNBC tissues and cells, and elucidate the functional mechanism of CXCL8 in paclitaxel (PTX)-resistant TNBC.	Paclitaxel	151-154	C-X-C motif chemokine ligand 8	Homo sapiens	130-135
34284965-5	2022	The protein expression and distribution of CXCL8 were examined by immunohistochemistry, MTT assay and colony formation assay were performed to determine cell viability of TNBC cells treated with PTX.	Paclitaxel	195-198	C-X-C motif chemokine ligand 8	Homo sapiens	43-48
34284965-10	2022	CXCL8 was upregulated in PTX-resistant TNBC cells.	Paclitaxel	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
34284965-11	2022	Knockdown of CXCL8 increased the sensitivity of TNBC cells to PTX.	Paclitaxel	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	13-18
34284965-12	2022	Mechanically, CXCL8 deficiency regulated PTX resistance in TNBC cells via cell apoptosis signaling pathway.	Paclitaxel	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	14-19
34234773-6	2021	Ultimately, one of the pathways through which CLEC12A regulates uric acid crystal-stimulated release of IL-8 by neutrophils is through a p38/PI3K-Akt signaling pathway.	Uric Acid	64-73	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
34204387-4	2021	18F-sodium fluoride (18F-NaF)-positron emission tomography (PET) is an emerging imaging modality with the potential for early diagnosis and monitoring of bone diseases through the detection of subtle metabolic changes.	18f-sodium fluoride	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	25-28
34114445-0	2021	Effect of interferon combined with entecavir on serum IL-8, CRP and INF-gamma levels in patients with chronic hepatitis B.	entecavir	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
34257799-14	2021	The concentrations of IL-1beta, IL-6, and IL-8 in the plasma were all decreased upon ZnO administration.	Zinc Oxide	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
34177139-4	2021	CS is marked by elevated levels of inflammatory cytokines, mainly interleukin-6 (IL-6), IL-8, IL-10, tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma).	Cesium	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
34179086-5	2021	RT-qPCR was used to detect the mRNA expression of inflammatory cytokines (CCL2, IL-8, CCL4) and genes associated with angiogenesis (VEGF, ANG-1, ANG-2) in early EPCs after treatment of LPC (10 mug/ml) or phosphatidylcholine (PC, 10 mug/ml, control).	Phosphatidylcholines	204-223	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
34179166-10	2021	Flu Avert treatment resulted in the modulation of IL-8, CCL2, and CXCL9 starting at days 5 and 6 post-treatment.	flu avert	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
34204056-3	2021	The ellagitannins (1 and 2) were evaluated on its inhibitory activities of the enzyme 5alpha-reductase and tumor necrosis factor (TNF)-alpha, its interleukin (IL)-1beta, IL-6, and IL-8 production, and its anti-proliferation and apoptosis induction in prostate cells that show hypertrophy (RWPE-1 cell).	Hydrolyzable Tannins	4-17	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
34201243-6	2021	Quantitative RT-PCR analysis revealed that irinotecan at 15 microM was able to amplify the antiviral response (i.e., interferon-stimulated gene expression) of HSF exposed to PIC and reduce the expression of pro-inflammatory genes (CXCL8, IL-6 and COX-2) upon IL-1beta treatment.	Irinotecan	43-53	C-X-C motif chemokine ligand 8	Homo sapiens	231-236
34108889-7	2021	iSN04 treatment recovered the deteriorated differentiation of plural DM myoblasts by downregulating myostatin and interleukin-8 (IL-8).	isn04	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	114-127
34086734-0	2021	Dose- and time-dependent changes in viability and IL-6, CXCL8 and CCL2 production by HaCaT-cells exposed to cobalt.	Cobalt	108-114	C-X-C motif chemokine ligand 8	Homo sapiens	56-61
34086734-12	2021	A linear mixed statistical model showed that cobalt exposure induces increase in IL-6, CXCL8 and CCL2 production over time and whereas increase of IL-6 and a decrease of CCL2 was associated with increasing cobalt chloride concentrations.	Cobalt	45-51	C-X-C motif chemokine ligand 8	Homo sapiens	87-92
34082514-0	2021	Incidental Skeletal Findings on Sodium-fluoride Positron Emission Tomography: A Collection of Benign Tumors Sodium-fluoride (NaF) positron emission tomography (PET) is a sensitive method to detect altered bone mineralization.	Sodium Fluoride	32-47	C-X-C motif chemokine ligand 8	Homo sapiens	125-128
34082514-0	2021	Incidental Skeletal Findings on Sodium-fluoride Positron Emission Tomography: A Collection of Benign Tumors Sodium-fluoride (NaF) positron emission tomography (PET) is a sensitive method to detect altered bone mineralization.	Sodium Fluoride	108-123	C-X-C motif chemokine ligand 8	Homo sapiens	125-128
32890135-10	2021	BOS with lower CCSP also induced Interleukin-8 and reduced vascular endothelial growth factor.	N-[4-(Aminosulfonyl)phenyl]-2-Mercaptobenzamide	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	33-46
34082668-11	2021	CONCLUSION: MMP2, CXCL8, PIK3R3, ITGB3, and LEF1 may play roles in the efficacy of vemurafenib treatment in melanoma; for example, MMP2 and PIK3R3 are likely associated with vemurafenib resistance.	Vemurafenib	83-94	C-X-C motif chemokine ligand 8	Homo sapiens	18-23
34114392-6	2021	RESULTS: The results showed that BYF, BJF and YZF treatment strongly decreased the CSE-induced secretion of interleukin (IL)-6, IL-8, tumor necrosis factor-alpha and matrix metalloproteinase-9 by THP-1 cells.	bjf	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
34114392-6	2021	RESULTS: The results showed that BYF, BJF and YZF treatment strongly decreased the CSE-induced secretion of interleukin (IL)-6, IL-8, tumor necrosis factor-alpha and matrix metalloproteinase-9 by THP-1 cells.	yzf	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
33577242-8	2021	With a BG concentration of 2.5%, IL-6 and IL-8 concentrations were smaller compared with the control group without BG after 2 days" incubation.	O(6)-benzylguanine	7-9	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
34108889-7	2021	iSN04 treatment recovered the deteriorated differentiation of plural DM myoblasts by downregulating myostatin and interleukin-8 (IL-8).	isn04	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
34063134-0	2021	Interleukin-6 and Interleukin-8 Regulate STAT3 Activation Migration/Invasion and EMT in Chrysophanol-Treated Oral Cancer Cell Lines.	chrysophanic acid	88-100	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
34071008-0	2021	Allicin Could Potentially Alleviate Oral Cancer Pain by Inhibiting "Pain Mediators" TNF-alpha, IL-8, and Endothelin.	allicin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
34071008-6	2021	Allicin inhibited both gene and protein expression of TNF-alpha, IL-8, and endothelin in both cancer cells and cancer stem cells.	allicin	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
34093525-4	2021	Using human monocyte/macrophage-like Thp-1 cells and human primary monocytes and macrophages, we were able to determine that a substantial part of early phagocytic cell activation, including NF-kappaB activation and IL-8 production, by live H. pylori is triggered by bacterial heptose metabolites.	Heptoses	277-284	C-X-C motif chemokine ligand 8	Homo sapiens	216-220
34063134-6	2021	However, the effect of chrysophanol on the production of IL-6 and IL-8 is unknown.	chrysophanic acid	23-35	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
34063134-9	2021	Our results showed that treatment with chrysophanol significantly decreased the expression of IL-6 and IL-8, as well as the invasion ability of oral cancer cells.	chrysophanic acid	39-51	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
34063134-11	2021	Mechanistically, chrysophanol inhibited IL-6- and IL-8-induced invasion and STAT3 phosphorylation.	chrysophanic acid	17-29	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
34602387-5	2021	The mRNA expression of TNF-alpha, IL-8 and IL-1beta in the azithromycin group was lower than that in the control group (P<0.05).	Azithromycin	59-71	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
34173106-4	2021	HUVEC cells cultured in the presence of high glucose concentration (30 mmol/ml) and treated with CXCL8 (50 ng/ml) demonstrated more intensive proliferation, migration, and p-ERK/ERK, p-P38/P38, and p-JNK/JNK ratios and significantly lower apoptosis rate than control cells (high glucose, no treatment) and cells treated with CXCL8 and transfected with microRNA-126-mimic.	Glucose	45-52	C-X-C motif chemokine ligand 8	Homo sapiens	97-102
34084299-7	2021	Patients with abnormal DMSA had significantly higher serum IL-6 and IL-8 compared with those with normal DMSA scan (187.1 +- 113.1 ng/mL vs. 396.1 +- 246.0 ng/mL, P = 0.005; and 165 +- 76.1 ng/mLvs.	Succimer	23-27	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
35513145-11	2022	Exposure of cells to large PS particles (500-5000 nm) upregulated interleukin-8 and the effect was enhanced at 24 h. Overall, the study demonstrated that smaller aminated particles were most toxic to hepatocytes, but larger particles induced apoptotic cell death or an inflammatory response depending on the length of exposure.	Phosphorus	27-29	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
34981477-0	2021	The Role of Chemokines in Cardiovascular Diseases and the Therapeutic Effect of Curcumin on CXCL8 and CCL2 as Pathological Chemokines in Atherosclerosis.	Curcumin	80-88	C-X-C motif chemokine ligand 8	Homo sapiens	92-97
34237749-10	2021	The presence of the copper ions prevented the dramatic increase of pro-inflammatory cytokines (interleukin (IL)-6 and IL-8) and transforming growth factor beta-1 that followed skin burning.	Copper	20-26	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
35489096-3	2022	With the first platform, the recognition layer consisted with immobilised IL-8 on aminothiol modified gold electrodes.	Aminothiol	82-92	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
35398417-4	2022	Here, we evaluated the associations between PM10, NO2 and O3 exposure (on the day of the blood sample collection and on the day before, and the mean annual residential level) and levels of the inflammatory biomarkers high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-1beta, IL-6, IL-8, IL-10, IL-17A, IL-22, and tumor necrosis factor alpha.	pm10	44-48	C-X-C motif chemokine ligand 8	Homo sapiens	292-296
35489096-7	2022	A side-by-side comparison showed that aminothiol/activated MWCNTs/anti-IL-8 based impedimetric immunosensor exhibits high reproducibility (The relative standard deviation (R.S.D) = 3.2%, n = 3) with high stability.	Aminothiol	38-48	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
35537534-3	2022	Then, the synergistic effects of NaF nanoparticles and DCV on adhesive performance were studied in terms of fluoride (F-) ion release, antibacterial activity, hydrophilicity, surface potential, cytotoxicity, and bonding strength.	Fluorides	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
35452830-12	2022	CONCLUSION: CRRT with topical citrate + low-dose LMW heparin-calcium anticoagulation in the treatment of patients with SAP reduces the levels of WBC, CRP, and PCT and the concentrations of cytokines, including IL-6, IL-8, and TNF-alpha.	Citric Acid	30-37	C-X-C motif chemokine ligand 8	Homo sapiens	216-220
35452830-12	2022	CONCLUSION: CRRT with topical citrate + low-dose LMW heparin-calcium anticoagulation in the treatment of patients with SAP reduces the levels of WBC, CRP, and PCT and the concentrations of cytokines, including IL-6, IL-8, and TNF-alpha.	Calcium	61-68	C-X-C motif chemokine ligand 8	Homo sapiens	216-220
35599022-6	2022	Microvessels exhibited physiological relevant trans-endothelial electrical resistance (TEER), were leak-tight for 10 kDa dextran-Alexa 647 and strongly limited the permeability of sodium fluorescein (NaF).	Fluorescein	180-198	C-X-C motif chemokine ligand 8	Homo sapiens	200-203
35537534-1	2022	OBJECTIVE: Aiming to achieve improved antibacterial performance for dental application, sodium fluoride (NaF) nanoparticles and photopolymerizable N,N-dodecylvinylimidazole (DCV) were co-introduced into resin adhesives at different ratios.	Sodium Fluoride	88-103	C-X-C motif chemokine ligand 8	Homo sapiens	105-108
35352237-6	2022	Furthermore, quercetin decreased the pro-inflammatory cell environment upon LPS-induced endothelial activation, in terms of tumor necrosis factor- alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), and sVCAM-1 expression.	Quercetin	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	188-201
35352237-6	2022	Furthermore, quercetin decreased the pro-inflammatory cell environment upon LPS-induced endothelial activation, in terms of tumor necrosis factor- alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), and sVCAM-1 expression.	Quercetin	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
35537534-5	2022	The cationic quaternary ammonium group could reduce the burst release of negative F- ion for the adhesive at a NaF/DCV ratio (1:1, 2 wt%), hence achieving both non-contact and contact antibacterial activity in an extended term without causing cytotoxicity.	quaternary ammonium	13-32	C-X-C motif chemokine ligand 8	Homo sapiens	111-114
35384906-10	2022	Recently, 18F-sodium fluoride (NaF) has been used for detection and quantification of molecular calcification in the plaques.	18f-sodium fluoride	10-29	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
34991200-0	2022	Effect of long-chain inorganic polyphosphate treated with wheat phytase on IL-8 signaling in HT-29 cells.	Polyphosphates	31-44	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
34991200-1	2022	Objective: This study was performed to investigate the potential effect of wheat phytase on long-chain inorganic polyphosphate (polyP)-mediated IL-8 signaling in an intestinal epithelial cell line, HT-29 cells.	Polyphosphates	113-126	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
34991200-1	2022	Objective: This study was performed to investigate the potential effect of wheat phytase on long-chain inorganic polyphosphate (polyP)-mediated IL-8 signaling in an intestinal epithelial cell line, HT-29 cells.	Polyphosphates	128-133	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
34991200-6	2022	Moreover, the 24 h exposure of cells to enzyme-treated 50 mM polyP1150 reduced the secretion of IL-8 and the activation of NF-kB by 9 and 19%, respectively, compared to the intact substrate.	polyp1150	61-70	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
35452996-7	2022	Evaluation of the cell death phenotype revealed that glutaminolysis inhibitory treatment with CB839 or a low-glutamine medium significantly promoted the proliferation of beta-galactosidase-positive and IL-6/IL-8 secretory cells among X-irradiated tumor cells, corresponding to an increase in the senescent cell population.	CB-839	94-99	C-X-C motif chemokine ligand 8	Homo sapiens	207-211
35452996-7	2022	Evaluation of the cell death phenotype revealed that glutaminolysis inhibitory treatment with CB839 or a low-glutamine medium significantly promoted the proliferation of beta-galactosidase-positive and IL-6/IL-8 secretory cells among X-irradiated tumor cells, corresponding to an increase in the senescent cell population.	Glutamine	109-118	C-X-C motif chemokine ligand 8	Homo sapiens	207-211
35170144-10	2022	Sputum inflammatory markers interleukin-1beta (P < 0.001), interleukin-8 (P < 0.001) and tumour necrosis factor-alpha (P = 0.003) were lower with gentamicin.	Gentamicins	146-156	C-X-C motif chemokine ligand 8	Homo sapiens	59-72
35623041-0	2022	Signaling via dopamine and adenosine receptors modulate viral peptide-specific and T-cell IL-8 response in COVID-19.	Dopamine	14-22	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
35623041-0	2022	Signaling via dopamine and adenosine receptors modulate viral peptide-specific and T-cell IL-8 response in COVID-19.	Adenosine	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
35623041-6	2022	We have found that (i) patients show marked IL-8 but not IL-17A responses; (ii) these responses are restricted by HLA-DR; and (iii) IL-8 responses are abrogated by a dopamine D2 like receptor (D2R) agonist, ropinirole, and an adenosine A2a receptor (A2aR) antagonist, istradefylline.	Dopamine	166-174	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
35623041-6	2022	We have found that (i) patients show marked IL-8 but not IL-17A responses; (ii) these responses are restricted by HLA-DR; and (iii) IL-8 responses are abrogated by a dopamine D2 like receptor (D2R) agonist, ropinirole, and an adenosine A2a receptor (A2aR) antagonist, istradefylline.	ropinirole	207-217	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
35623041-6	2022	We have found that (i) patients show marked IL-8 but not IL-17A responses; (ii) these responses are restricted by HLA-DR; and (iii) IL-8 responses are abrogated by a dopamine D2 like receptor (D2R) agonist, ropinirole, and an adenosine A2a receptor (A2aR) antagonist, istradefylline.	istradefylline	268-282	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
35605724-10	2022	Copper exposure stimulated 16HBE cells to release proinflammatory IL-6 and IL-8.	Copper	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
35603939-11	2022	In HCT116 cells, tunicamycin increased the expression of Grp78, Gro-alpha and IL-8 in a concentration-dependent manner.	Tunicamycin	17-28	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
35603939-12	2022	Furthermore, p38 MAPK inhibitor significantly inhibited the upregulation of Gro-alpha and IL-8 induced by tunicamycin.	Tunicamycin	106-117	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
35631467-8	2022	Further analysis of unique compounds found in A. dracunculus showed that farnesene, a compound with a similar hydrocarbon structure as lipoxin A4, inhibited Ca2+ influx induced in human neutrophils by fMLF (IC50 = 1.2 muM), WKYMVM (IC50 = 1.4 muM), or interleukin 8 (IC50 = 2.6 muM).	Sesquiterpenes	73-82	C-X-C motif chemokine ligand 8	Homo sapiens	252-265
35589610-0	2022	Ladarixin, an inhibitor of IL-8 receptors CXCR1 and CXCR2, in new-onset type 1 diabetes: a multicenter, randomized, double-blind, placebo-controlled trial.	2'-((4'-trifluoromethanesulfonyloxy)phenyl)-N-methanesulfonylpropionamide	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
35631269-2	2022	In this study, the ability to regulate the production of IL-8 of the water-soluble non-starch polysaccharide (WS-NSP) from taro corm (Tc-WS-NSP) extracted using a conventional (CE) or improved conventional (ICE) extraction method, of the probiotics Lactobacillus acidophilus, Bifidobacterium breve, and Bifidobacterium infantis, and their synbiotic mixtures were evaluated.	ws-nsp	110-116	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
35631269-2	2022	In this study, the ability to regulate the production of IL-8 of the water-soluble non-starch polysaccharide (WS-NSP) from taro corm (Tc-WS-NSP) extracted using a conventional (CE) or improved conventional (ICE) extraction method, of the probiotics Lactobacillus acidophilus, Bifidobacterium breve, and Bifidobacterium infantis, and their synbiotic mixtures were evaluated.	Water	69-74	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
35631269-2	2022	In this study, the ability to regulate the production of IL-8 of the water-soluble non-starch polysaccharide (WS-NSP) from taro corm (Tc-WS-NSP) extracted using a conventional (CE) or improved conventional (ICE) extraction method, of the probiotics Lactobacillus acidophilus, Bifidobacterium breve, and Bifidobacterium infantis, and their synbiotic mixtures were evaluated.	Tungsten	137-139	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
35631269-2	2022	In this study, the ability to regulate the production of IL-8 of the water-soluble non-starch polysaccharide (WS-NSP) from taro corm (Tc-WS-NSP) extracted using a conventional (CE) or improved conventional (ICE) extraction method, of the probiotics Lactobacillus acidophilus, Bifidobacterium breve, and Bifidobacterium infantis, and their synbiotic mixtures were evaluated.	Starch	87-93	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
35631269-5	2022	The ability demonstrated by the Tc-WS-NSPs, the probiotics, and their synbiotics mixtures to downregulate IL-8 production in the presence of an NEC-positive-associated pathogen may be useful in the development of novel prophylactic agents against NEC.	tc-ws	32-37	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
35631269-2	2022	In this study, the ability to regulate the production of IL-8 of the water-soluble non-starch polysaccharide (WS-NSP) from taro corm (Tc-WS-NSP) extracted using a conventional (CE) or improved conventional (ICE) extraction method, of the probiotics Lactobacillus acidophilus, Bifidobacterium breve, and Bifidobacterium infantis, and their synbiotic mixtures were evaluated.	Polysaccharides	94-108	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
35570777-9	2022	The relationships of IL-6 and IL-8 in ME/CFS and S-ME/CFS participants also differed from Cs.	2-(N-morpholino)ethanesulfonic acid	49-53	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
35503917-4	2022	A pathway to obtain single crystals was shown by growing NaSrY(BO3)2 and NaSrYb(BO3)2 by the top seeded solution growth method with Na2O-B2O3-NaF flux.	sodium oxide	132-136	C-X-C motif chemokine ligand 8	Homo sapiens	142-145
35589431-1	2022	AIM: To investigate if the pattern of fluorine-18-labelled sodium fluoride (18F-NaF) uptake on integrated positron-emission tomography (PET)/magnetic resonance imaging (MRI) of bone marrow lesions (BML) and osteophytes differs between different knee compartments.	Fluorine	38-46	C-X-C motif chemokine ligand 8	Homo sapiens	80-83
35589431-1	2022	AIM: To investigate if the pattern of fluorine-18-labelled sodium fluoride (18F-NaF) uptake on integrated positron-emission tomography (PET)/magnetic resonance imaging (MRI) of bone marrow lesions (BML) and osteophytes differs between different knee compartments.	Sodium Fluoride	59-74	C-X-C motif chemokine ligand 8	Homo sapiens	80-83
35503917-4	2022	A pathway to obtain single crystals was shown by growing NaSrY(BO3)2 and NaSrYb(BO3)2 by the top seeded solution growth method with Na2O-B2O3-NaF flux.	boron oxide	137-141	C-X-C motif chemokine ligand 8	Homo sapiens	142-145
35574627-8	2022	Also, curcumin supplementation elicited significant improvements in MVC (WMD = 3.10 nm, 95% CI (1.45-4.75)) and ROM (WMD = 6.49 , 95% CI (3.91-9.07)), although no significant changes in IL-6 and IL-8 levels were found.	Curcumin	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
35576915-11	2022	CONCLUSION: Our results show that active tVNS led to an immediate increase in the serum concentrations of certain pro-inflammatory cytokines such as IL-1beta, IL-6, and/or IL-8 in two independent cohorts of healthy study participants.	tvns	41-45	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
35625855-7	2022	In RASF, THC (>=5 microM) increased intracellular calcium levels/PoPo3 uptake in a TRPA1-dependent manner and reduced interleukin-8 (IL-8) and matrix metalloprotease 3 (MMP-3) production at high concentrations (25 microM).	Dronabinol	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	118-131
35570014-1	2022	OBJECTIVES: The objectives of this study were to compare the amount of fluoride delivered via a topical application of 38% silver diamine fluoride (SDF) solution and 5% sodium fluoride (NaF) varnish as well as to determine the amount of 38% SDF solution delivered using various micro-applicators.	Fluorides	71-79	C-X-C motif chemokine ligand 8	Homo sapiens	186-189
35570014-1	2022	OBJECTIVES: The objectives of this study were to compare the amount of fluoride delivered via a topical application of 38% silver diamine fluoride (SDF) solution and 5% sodium fluoride (NaF) varnish as well as to determine the amount of 38% SDF solution delivered using various micro-applicators.	Sodium Fluoride	169-184	C-X-C motif chemokine ligand 8	Homo sapiens	186-189
35570014-2	2022	METHODS: The weights of 38% SDF (Saforide) and 5% NaF (Duraphat) applied to the occlusal surface of an extracted human upper first premolar with a regular-size (2.50-mm tip diameter) micro-applicator were measured using an electronic-analytical balance.	sodium fluoride topical preparation	55-63	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
35570014-6	2022	RESULTS: The mean weights of the fluoride delivered via the SDF solution and NaF varnish were 0.25 +- 0.07 mg and 0.49 +- 0.08 mg, respectively (P < .001).	Fluorides	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
35625855-7	2022	In RASF, THC (>=5 microM) increased intracellular calcium levels/PoPo3 uptake in a TRPA1-dependent manner and reduced interleukin-8 (IL-8) and matrix metalloprotease 3 (MMP-3) production at high concentrations (25 microM).	Dronabinol	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
35570279-5	2022	RESULTS: HRV-Cs infect and propagate in fully differentiated HBE cells and significantly increase the secretion of IFN-lambda1, CCL5, IP10, IL-6, IL-8, and MCP-1.	hrv-cs	9-15	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
35570014-0	2022	Fluoride Delivered via a Topical Application of 38% SDF and 5% NaF.	Fluorides	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
35546010-0	2022	Ozone improved the wound healing in type 2 diabetics via down-regulation of IL- 8, 10 and induction of FGFR expression.	Ozone	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	76-81
35521772-10	2022	The concentrations of follicular IL-6, IL-8 and mature IL-18 were significantly higher in PCOS group and were positively correlated with the levels of fatty acids.	Fatty Acids	151-162	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
35624784-4	2022	CDCA treatment provoked ROS production, followed by IL-8 and ICAM-1 expression in hepatocytes within 8 h, which accelerated 24 h post-treatment.	Chenodeoxycholic Acid	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
35624784-7	2022	In contrast, SP treatment reduced ROS production and blocked IL-8/ICAM-1 in CDCA-injured hepatocytes.	Chenodeoxycholic Acid	76-80	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
35535007-10	2022	IL-8 concentration in cultures stimulated with talc and adenocarcinoma supernatant was higher compared to cultures stimulated with talc only.	Talc	47-51	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
35521772-11	2022	Moreover, oleic acid stimulation upregulated the transcription levels of IL-6 and IL-8 via ERK1/2 signaling pathways in KGN cells.	Oleic Acid	10-20	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
35600871-11	2022	Additionally, TNF-alpha-induced IL-8 production in BEAS-2B cells was not completely inhibited by Dex, while R406 markedly promoted the anti-inflammatory effect of Dex.	Dexamethasone	97-100	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
35600871-11	2022	Additionally, TNF-alpha-induced IL-8 production in BEAS-2B cells was not completely inhibited by Dex, while R406 markedly promoted the anti-inflammatory effect of Dex.	Dexamethasone	163-166	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
35315502-4	2022	In the present study, the efficacy of co-targeting IL-6 and IL-8 in human ovarian cancer cells by bazedoxifene (Baze) + SCH527123 (SCH) treatment was examined.	bazedoxifene	98-110	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
35571237-5	2022	In vitro, miR-150-5p overexpression decreased the contents of inflammatory factors interleukin- (IL-) 6, IL-8 along with cyclooxygenase-2 (COX-2), and endoplasmic reticulum (ER) stress markers glucose-regulated protein (GRP) 78 and C/-EBP homologous protein (CHOP) and promoted cell migrate.	mir-150-5p	10-20	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
35247648-5	2022	There are four cysteine residues forming two disulfide linkage and 14 basic amino acid residues which result in a very basic property for the binding of IL-8 to heparan sulfate-proteoglycan.	Cysteine	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
35247648-5	2022	There are four cysteine residues forming two disulfide linkage and 14 basic amino acid residues which result in a very basic property for the binding of IL-8 to heparan sulfate-proteoglycan.	Disulfides	45-54	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
35247648-5	2022	There are four cysteine residues forming two disulfide linkage and 14 basic amino acid residues which result in a very basic property for the binding of IL-8 to heparan sulfate-proteoglycan.	Amino Acids, Basic	70-86	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
35247648-5	2022	There are four cysteine residues forming two disulfide linkage and 14 basic amino acid residues which result in a very basic property for the binding of IL-8 to heparan sulfate-proteoglycan.	Heparitin Sulfate	161-176	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
35278812-7	2022	Nitrites significantly correlated with IL-8 during relapse.	Nitrites	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
35421827-3	2022	Using Sprague-Dawley rats exposed to sodium fluoride (NaF) from gestation through delivery until the neonatal offspring reached six months of age as an in vivo model.	Sodium Fluoride	37-52	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
35421827-8	2022	Mechanistically, V-ATPase B2 overexpression and ATP effectively restored V-ATPase expression, reducing NaF-induced lysosomal alkalinization while increasing lysosomal degradation capacity.	Adenosine Triphosphate	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	103-106
35412656-9	2022	Additionally, ectoine reduces production of AREG and interleukin-8 by CF primary bronchial epithelial cells.	ectoine	14-21	C-X-C motif chemokine ligand 8	Homo sapiens	53-66
34989247-8	2022	We propose that sample tubes containing NaF-EDTA-citrate be used for the measurement of uric acid in patients administered rasburicase.	Uric Acid	88-97	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
35506423-6	2022	Secondly, Everolimus significantly reduced the expressions of the pro-inflammatory cytokines interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha), and IL-8.	Everolimus	10-20	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
35429917-9	2022	RESULTS: In LMM, a two-fold increase in urinary cesium (Cs) and chromium (Cr) was statistically associated with -35.22% (95% confidence interval (CI): -53.17, -10.40) changes in interleukin 6 (IL-6) and -11.13% (95 %CI: -20.67, -0.44) in IL-8.	Cesium	48-54	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
35429917-9	2022	RESULTS: In LMM, a two-fold increase in urinary cesium (Cs) and chromium (Cr) was statistically associated with -35.22% (95% confidence interval (CI): -53.17, -10.40) changes in interleukin 6 (IL-6) and -11.13% (95 %CI: -20.67, -0.44) in IL-8.	Cesium	56-58	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
35429917-9	2022	RESULTS: In LMM, a two-fold increase in urinary cesium (Cs) and chromium (Cr) was statistically associated with -35.22% (95% confidence interval (CI): -53.17, -10.40) changes in interleukin 6 (IL-6) and -11.13% (95 %CI: -20.67, -0.44) in IL-8.	Chromium	64-72	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
35429917-9	2022	RESULTS: In LMM, a two-fold increase in urinary cesium (Cs) and chromium (Cr) was statistically associated with -35.22% (95% confidence interval (CI): -53.17, -10.40) changes in interleukin 6 (IL-6) and -11.13% (95 %CI: -20.67, -0.44) in IL-8.	Chromium	74-76	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
35315502-4	2022	In the present study, the efficacy of co-targeting IL-6 and IL-8 in human ovarian cancer cells by bazedoxifene (Baze) + SCH527123 (SCH) treatment was examined.	bazedoxifene	112-116	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
35315502-4	2022	In the present study, the efficacy of co-targeting IL-6 and IL-8 in human ovarian cancer cells by bazedoxifene (Baze) + SCH527123 (SCH) treatment was examined.	2-hydroxy-N,N-dimethyl-3-(2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-enylamino)benzamide	120-129	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
35315502-4	2022	In the present study, the efficacy of co-targeting IL-6 and IL-8 in human ovarian cancer cells by bazedoxifene (Baze) + SCH527123 (SCH) treatment was examined.	2-hydroxy-N,N-dimethyl-3-(2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-enylamino)benzamide	131-134	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
35315502-8	2022	Compared with the DMSO control, the combination of IL-6/glycoprotein 130 inhibitor Baze and IL-8 inhibitor SCH synergistically inhibited cell viability in ovarian cancer cells.	2-hydroxy-N,N-dimethyl-3-(2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-enylamino)benzamide	107-110	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
35437207-7	2022	RESULTS: EKH significantly induced IL-6 and IL-8 in NHDF and HMVEC-dBl.	5-Chlorotubercidin	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
35403296-9	2022	After vitamin D supplementation for 90 days, T2DM patients had a 2-fold increase of GSH levels, from 2.72 +- 0.84 to 5.76 +- 3.19 mumol/ml, the concentration of MCP-1 decreased from 51.11 +- 20.86 to 25.42 +- 13.06 pg/ml, and IL-8 also decreased from 38.21 +- 21.76 to 16.05 +- 8.99 pg/ml.	Vitamin D	6-15	C-X-C motif chemokine ligand 8	Homo sapiens	226-230
35403296-10	2022	In conclusion, our study demonstrated that vitamin D could regulate the production of GSH, thereby reducing the serum levels of MCP-1 and IL-8, alleviating oxidative stress and inflammation, providing evidence of the necessity and feasibility of adjuvant vitamin D treatment among patients with T2DM.	Vitamin D	43-52	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
35150143-6	2022	White blood cells, neutrophils, platelets, erythrocyte sedimentation rate (ESR), and the levels of interleukin-8 significantly decreased in the nano-curcumin group compared to the placebo after 10 days of intervention (p = .024, p = .045, p = .017, p = .041, and p = .004, respectively).	Curcumin	149-157	C-X-C motif chemokine ligand 8	Homo sapiens	99-112
35150143-16	2022	For the first time, this trial was conducted to determine the effect of nano-curcumin on hematological indices and the serum levels of presepsin and IL-8.	nano-curcumin	72-85	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
35487914-6	2022	IL8-targeted by RNA interference or reparixin reversed chemotherapy resistance with limited toxicity in vivo and vitro experiments.	reparixin	36-45	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
35306372-3	2022	Photochemical oxidation of isoprene leads to the formation of hydroperoxides, environmental oxidants that lead to inflammatory (IL-8) and adaptive (HMOX1) gene expression in human airway epithelial cells (HAEC).	isoprene	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
35306372-3	2022	Photochemical oxidation of isoprene leads to the formation of hydroperoxides, environmental oxidants that lead to inflammatory (IL-8) and adaptive (HMOX1) gene expression in human airway epithelial cells (HAEC).	Hydrogen Peroxide	62-76	C-X-C motif chemokine ligand 8	Homo sapiens	128-132
35563819-10	2022	The infiltration of T cells into the epidermis was reduced when ALA was added to the culture medium, and significant decreases in the levels of inflammatory cytokines and chemokines such as CXCL1, interleukin-6 (IL-6) and interleukin-8 (IL-8) were consequently measured in psoriatic substitutes supplemented with this n-3 PUFA.	alpha-Linolenic Acid	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	222-235
35563819-10	2022	The infiltration of T cells into the epidermis was reduced when ALA was added to the culture medium, and significant decreases in the levels of inflammatory cytokines and chemokines such as CXCL1, interleukin-6 (IL-6) and interleukin-8 (IL-8) were consequently measured in psoriatic substitutes supplemented with this n-3 PUFA.	alpha-Linolenic Acid	64-67	C-X-C motif chemokine ligand 8	Homo sapiens	237-241
35352794-8	2022	ER stress inducer significantly increased while ER stress inhibitor TUDCA significantly decreased the expression and secretion of TNF-alpha, IL-1beta and IL-8 in THP-1 cells treated by LPS.	ursodoxicoltaurine	68-73	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
35352794-10	2022	Furthermore, p38 inhibitor SB203580 inhibited the production and secretion of TNF-alpha, IL-1beta and IL-8 in THP-1 cells treated with LPS.	SB 203580	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
35563797-9	2022	Six months after completion of the BPA treatment, there was a decrease in concentrations of IL-6 (  = -1.61 (-3.11; -0.20); p = 0.03), of IL8 (  = -3.24 (-7.72; 0.82); p = 0.01), and of ET-1 (  = -0.47 (-0.96; 0.05); p = 0.005).	bisphenol A	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	138-141
35216930-1	2022	OBJECTIVES: The aim of this study was to describe the potential of 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) to identify graft vasculopathy and to investigate the influence of coronary artery bypass graft (CABG) surgery on native coronary artery disease activity and progression.	18f-sodium fluoride	67-86	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
35509603-15	2022	HIF-1a stimulation by dimethyloxalylglycine (DMOG) could restore IL-8 secretion in SLC16A3 downregulated cells.	oxalylglycine	22-43	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
35509603-15	2022	HIF-1a stimulation by dimethyloxalylglycine (DMOG) could restore IL-8 secretion in SLC16A3 downregulated cells.	oxalylglycine	45-49	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
35199431-6	2022	As proven, weak ion solvation/desolvation of tetrahydrofuran greatly facilitates fast-ion diffusion at the SEI/electrolyte interface and homogeneous SEI with well-distributed NaF and organic components ensures fast Na+ diffusion through the SEI layer and a stable interface.	tetrahydrofuran	45-60	C-X-C motif chemokine ligand 8	Homo sapiens	175-178
35443035-7	2022	Moreover, ATP and ADP were significantly positively correlated with the Positive and Negative Symptom Scale (PANSS) item "lack of judgment and insight"; IL-1beta, IL-12 and TNF-alpha were significantly positively correlated with "tension" and "depression"; and "disorientation" and "poor attention" were correlated significantly with IL-6 and IL-8.	Adenosine Triphosphate	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	343-347
35509853-9	2022	Additionally, miR-141-3p could reduce IL-6 and IL-8.	mir-141-3p	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
35593365-12	2022	The results indicated that quercetin and wogonin had better affinity with CXCL8, CCL2 or IL1B.	Quercetin	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	74-79
35593365-12	2022	The results indicated that quercetin and wogonin had better affinity with CXCL8, CCL2 or IL1B.	wogonin	41-48	C-X-C motif chemokine ligand 8	Homo sapiens	74-79
35593365-14	2022	The expression CXCL8, CCL2 or IL1B were down-regulated after quercetin or wogonin treating, compared with LPS-induced A549 cells (P < 0.01).	Quercetin	61-70	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
35593365-14	2022	The expression CXCL8, CCL2 or IL1B were down-regulated after quercetin or wogonin treating, compared with LPS-induced A549 cells (P < 0.01).	wogonin	74-81	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
35441257-2	2022	Nicotine has been shown to stimulate the production of cytokines that are priming agents for inflammation that induces tissue destruction, such as IL-1beta, IL-6, and IL-8, by gingival keratinocytes and human gingival fibroblasts (HGF).	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
35441257-8	2022	Nicotine elevated the expression of pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17 and decreased the anti-inflammatory IL-10 in HGFs at 24 and 72 h. Boric acid at 100 ng/mL in the medium prevented the changes induced by nicotine alone.	Nicotine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
35563697-10	2022	Our multiplex ELISA data revealed that CBD and THC significantly diminished the levels of IL-6, IL-8, and tumor necrosis factor-alpha (TNF-alpha) after LPS treatment in THP-1 macrophages and HBECs.	Cannabidiol	39-42	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
35563697-10	2022	Our multiplex ELISA data revealed that CBD and THC significantly diminished the levels of IL-6, IL-8, and tumor necrosis factor-alpha (TNF-alpha) after LPS treatment in THP-1 macrophages and HBECs.	Dronabinol	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
35460727-9	2022	Increased uric acid levels were positively correlated with mucosal neutrophil numbers and IFN-gamma, IL-17A, IL-1beta, and IL-8 mRNA levels.	Uric Acid	10-19	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
35443035-7	2022	Moreover, ATP and ADP were significantly positively correlated with the Positive and Negative Symptom Scale (PANSS) item "lack of judgment and insight"; IL-1beta, IL-12 and TNF-alpha were significantly positively correlated with "tension" and "depression"; and "disorientation" and "poor attention" were correlated significantly with IL-6 and IL-8.	Adenosine Diphosphate	18-21	C-X-C motif chemokine ligand 8	Homo sapiens	343-347
35460727-13	2022	Glutathione treatment reduced IL-8 mRNA expression in cultured nasal polyp tissues.	Glutathione	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
35456686-7	2022	Furthermore, the produced RSV-PCL microparticles reduced the expression of inflammatory (IL-6, IL-8, COX-2) and proteolytic (MMP-2, MMP-9) mediators.	rsv-pcl	26-33	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
35492731-1	2022	Objective: The interleukin-8 (IL-8) has been reported to play an important role in depression, which might be modulated by the selective serotonin reuptake inhibitors (SSRIs).	Serotonin	137-146	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
35492731-1	2022	Objective: The interleukin-8 (IL-8) has been reported to play an important role in depression, which might be modulated by the selective serotonin reuptake inhibitors (SSRIs).	Serotonin	137-146	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
35352717-5	2022	Functional assays using human monocytes revealed that docosyl alpha-glucopyranoside leads to significantly higher levels of IL-1beta and IL-8 production by monocytes compared to those elicited by trehalose dibehenate (TDB).	docosyl alpha-glucopyranoside	54-83	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
35352717-5	2022	Functional assays using human monocytes revealed that docosyl alpha-glucopyranoside leads to significantly higher levels of IL-1beta and IL-8 production by monocytes compared to those elicited by trehalose dibehenate (TDB).	TDB	218-221	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
35498406-0	2022	Vitamin D Reduces Thyroid Cancer Cells Migration Independently From the Modulation of CCL2 and CXCL8 Chemokines Secretion.	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	95-100
35498406-5	2022	The aim of the present study was to investigate if vitamin D could modulate both thyroid cancer cell migration and their ability to secrete CCL2 and CXCL8.	Vitamin D	51-60	C-X-C motif chemokine ligand 8	Homo sapiens	149-154
35498406-9	2022	Vitamin D differently modulated the secretion of CCL2 and CXCL8, by significantly inhibiting the secretion of CCL2 in both thyroid cancer cell lines and inhibiting the secretion of CXCL8 only in TPC-1 (ANOVAs p < 0.05).	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	58-63
35498406-9	2022	Vitamin D differently modulated the secretion of CCL2 and CXCL8, by significantly inhibiting the secretion of CCL2 in both thyroid cancer cell lines and inhibiting the secretion of CXCL8 only in TPC-1 (ANOVAs p < 0.05).	Vitamin D	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	181-186
35498406-11	2022	Future studies specifically designed at clarifying the pathways involved in the different inhibitory effects of vitamin D on CCL2 and CXCL8 in thyroid cancer cells appear worthwhile.	Vitamin D	112-121	C-X-C motif chemokine ligand 8	Homo sapiens	134-139
35465355-14	2022	alpha-Bisabolol significantly decreased the expression of proinflammatory chemokines (CXCL-1 and IL-8) mRNA in HT-29 cells treated with TNF-alpha and HT-29 PPAR-gamma promoter activity.	alpha-Bisabolol	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
35413833-8	2022	We also found that GluOC upregulated the expression of interleukin-8 (IL-8) and parathyroid hormone-related protein (PTHrP) genes in MDA-MB-231 breast cancer cells.	gluoc	19-24	C-X-C motif chemokine ligand 8	Homo sapiens	55-68
35413833-8	2022	We also found that GluOC upregulated the expression of interleukin-8 (IL-8) and parathyroid hormone-related protein (PTHrP) genes in MDA-MB-231 breast cancer cells.	gluoc	19-24	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
35391557-5	2022	Bioinformatic analysis reveals that SMG may activates ERK5/NF-kappaB/IL-8 axis that triggers the expansion of cancer stem cells with an increased migratory capability.	N-SUCCINYL METHIONINE	36-39	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
35413833-11	2022	Moreover, GluOC also promotes the gene expression of IL-8 and PTHrP.	gluoc	10-15	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
35450405-9	2022	In human epidermal keratinocytes, trehalose-induced autophagy and inhibition of the interleukin-8 expression were blocked by ATG9A but not TIMP3 siRNA.	Trehalose	34-43	C-X-C motif chemokine ligand 8	Homo sapiens	84-97
35448516-0	2022	Low-Concentrations of Fatty Acids Induce an Early Increase in IL-8 Levels in Normal Human Astrocytes.	Fatty Acids	22-33	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
35381948-11	2022	In the binary logistic regression analysis, erythrocyte selenium was considered an independent predictor of the serum concentrations of cytokine IL-8 in obese women, reflecting the anti-inflammatory action of this micronutrient.	Selenium	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
35448516-8	2022	In conclusion, low concentrations of oleic acid are able to induce an early increase in IL-8 expression in normal human astrocytes, which is specifically downregulated by SSO.	Oleic Acid	37-47	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
35063608-4	2022	The fluoride strips based PPC (NaF-PPC strips) with different fluoride contents (0, 1.25, 2.5 and 5 wt.%) were developed by melt-blending method.	Fluorides	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
35479322-16	2022	Conclusion: A single sub-anesthetic dose (0.3 mg kg-1) of ketamine can significantly improve the postoperative anxiety and depression of colorectal cancer patients and reduce the levels of IL-6, IL-8, and TNF-alpha.	Ketamine	58-66	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
35365616-8	2022	Thus, we revealed a potential approach to explore small-molecule antagonists such as reparixin attenuating IL-8 signaling for treatment of human cancer patients detected with hyper-editing.	reparixin	85-94	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
35218508-0	2022	Therapy-induced bone changes in oncology imaging with 18F-sodium fluoride (NaF) PET-CT. 18F-Sodium fluoride (18F-NaF) is a PET tracer that is mostly used in the evaluation of bone metastasis in oncology cases.	18f-sodium fluoride	54-73	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
35218508-0	2022	Therapy-induced bone changes in oncology imaging with 18F-sodium fluoride (NaF) PET-CT. 18F-Sodium fluoride (18F-NaF) is a PET tracer that is mostly used in the evaluation of bone metastasis in oncology cases.	18f-sodium fluoride	54-73	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
35218508-0	2022	Therapy-induced bone changes in oncology imaging with 18F-sodium fluoride (NaF) PET-CT. 18F-Sodium fluoride (18F-NaF) is a PET tracer that is mostly used in the evaluation of bone metastasis in oncology cases.	18f-sodium fluoride	88-107	C-X-C motif chemokine ligand 8	Homo sapiens	75-78
35218508-0	2022	Therapy-induced bone changes in oncology imaging with 18F-sodium fluoride (NaF) PET-CT. 18F-Sodium fluoride (18F-NaF) is a PET tracer that is mostly used in the evaluation of bone metastasis in oncology cases.	18f-sodium fluoride	88-107	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
35450316-7	2022	Results: BG brought out the increased gene and protein expression of inflammatory biomarkers such as interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor-alpha, in the LPS-treated sebocytes and ORS cells.	O(6)-benzylguanine	9-11	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
35063608-7	2022	NaF-PPC strips exhibited excellent remineralization and antibacterial potential when fluoride content up to 5%.	Fluorides	85-93	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
35063608-8	2022	Combination with biocompatibility, 2.5% NaF-PPC strips could be a promising fluoride application for preventing caries.	Fluorides	76-84	C-X-C motif chemokine ligand 8	Homo sapiens	40-43
35264742-3	2022	Here, we show that CAFR, a CAF subset derived from platinum-resistant PDAC patients, assumes an iCAF phenotype and produces more IL8 than CAFS isolated from platinum-sensitive PDAC patients.	cafr	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	129-132
35264742-4	2022	CAFR-derived IL8 promotes oxaliplatin chemoresistance in PDAC.	cafr	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
35264742-4	2022	CAFR-derived IL8 promotes oxaliplatin chemoresistance in PDAC.	Oxaliplatin	26-37	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
35264742-5	2022	Based on long noncoding RNA (lncRNA) profiling in tumor cells incubated with CAF-CM, we found that UPK1A-AS1, whose expression is directly induced by IL8/NF-kappa B signaling, functions as a chemoresistance-promoting lncRNA and is critical for active IL8-induced oxaliplatin resistance.	Oxaliplatin	263-274	C-X-C motif chemokine ligand 8	Homo sapiens	150-153
35264742-9	2022	Collectively, our study reveals a lncRNA-mediated mechanism of CAF-derived paracrine IL8-dependent oxaliplatin resistance and highlights UPK1A-AS1 as a potential therapeutic target.	Oxaliplatin	99-110	C-X-C motif chemokine ligand 8	Homo sapiens	85-88
35365723-6	2022	IL-8, IL-6 and TNF-alpha secretion was induced by LPA in MDA-MB-468 cells.	lysophosphatidic acid	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
35355134-2	2022	The Ru-AuNPs/GNP/Naf complex was formed by combining the Rubpy32+-AuNPs complex (Ru-AuNPs), prepared by modifying the negatively charged surface of gold nanoparticles (AuNPs) with positively charged Rubpy32+ through electrostatic interactions and the graphene nanoplatelets-Nafion (GNP/Naf) at a ratio of 2:1.	ru-aunps	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
35355134-2	2022	The Ru-AuNPs/GNP/Naf complex was formed by combining the Rubpy32+-AuNPs complex (Ru-AuNPs), prepared by modifying the negatively charged surface of gold nanoparticles (AuNPs) with positively charged Rubpy32+ through electrostatic interactions and the graphene nanoplatelets-Nafion (GNP/Naf) at a ratio of 2:1.	ru-aunps	4-12	C-X-C motif chemokine ligand 8	Homo sapiens	286-289
35355134-2	2022	The Ru-AuNPs/GNP/Naf complex was formed by combining the Rubpy32+-AuNPs complex (Ru-AuNPs), prepared by modifying the negatively charged surface of gold nanoparticles (AuNPs) with positively charged Rubpy32+ through electrostatic interactions and the graphene nanoplatelets-Nafion (GNP/Naf) at a ratio of 2:1.	rubpy32+-aunps	57-71	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
35355134-2	2022	The Ru-AuNPs/GNP/Naf complex was formed by combining the Rubpy32+-AuNPs complex (Ru-AuNPs), prepared by modifying the negatively charged surface of gold nanoparticles (AuNPs) with positively charged Rubpy32+ through electrostatic interactions and the graphene nanoplatelets-Nafion (GNP/Naf) at a ratio of 2:1.	rubpy32+-aunps	57-71	C-X-C motif chemokine ligand 8	Homo sapiens	286-289
35355134-2	2022	The Ru-AuNPs/GNP/Naf complex was formed by combining the Rubpy32+-AuNPs complex (Ru-AuNPs), prepared by modifying the negatively charged surface of gold nanoparticles (AuNPs) with positively charged Rubpy32+ through electrostatic interactions and the graphene nanoplatelets-Nafion (GNP/Naf) at a ratio of 2:1.	ru-aunps	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
35355134-2	2022	The Ru-AuNPs/GNP/Naf complex was formed by combining the Rubpy32+-AuNPs complex (Ru-AuNPs), prepared by modifying the negatively charged surface of gold nanoparticles (AuNPs) with positively charged Rubpy32+ through electrostatic interactions and the graphene nanoplatelets-Nafion (GNP/Naf) at a ratio of 2:1.	ru-aunps	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	286-289
35355134-2	2022	The Ru-AuNPs/GNP/Naf complex was formed by combining the Rubpy32+-AuNPs complex (Ru-AuNPs), prepared by modifying the negatively charged surface of gold nanoparticles (AuNPs) with positively charged Rubpy32+ through electrostatic interactions and the graphene nanoplatelets-Nafion (GNP/Naf) at a ratio of 2:1.	rubpy32+	199-207	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
35355134-2	2022	The Ru-AuNPs/GNP/Naf complex was formed by combining the Rubpy32+-AuNPs complex (Ru-AuNPs), prepared by modifying the negatively charged surface of gold nanoparticles (AuNPs) with positively charged Rubpy32+ through electrostatic interactions and the graphene nanoplatelets-Nafion (GNP/Naf) at a ratio of 2:1.	Graphite	251-259	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
35355134-2	2022	The Ru-AuNPs/GNP/Naf complex was formed by combining the Rubpy32+-AuNPs complex (Ru-AuNPs), prepared by modifying the negatively charged surface of gold nanoparticles (AuNPs) with positively charged Rubpy32+ through electrostatic interactions and the graphene nanoplatelets-Nafion (GNP/Naf) at a ratio of 2:1.	perfluorosulfonic acid	274-280	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
35355134-4	2022	A layer of chitosan (CS) was coated onto this modified electrode, and later amine-terminated beta-LG aptamers were covalently attached to the CS/Ru-AuNP/GNP/Naf via glutaraldehyde (GLUT) cross-linking.	Amines	76-81	C-X-C motif chemokine ligand 8	Homo sapiens	157-160
35355134-4	2022	A layer of chitosan (CS) was coated onto this modified electrode, and later amine-terminated beta-LG aptamers were covalently attached to the CS/Ru-AuNP/GNP/Naf via glutaraldehyde (GLUT) cross-linking.	Chitosan	142-144	C-X-C motif chemokine ligand 8	Homo sapiens	157-160
35355134-4	2022	A layer of chitosan (CS) was coated onto this modified electrode, and later amine-terminated beta-LG aptamers were covalently attached to the CS/Ru-AuNP/GNP/Naf via glutaraldehyde (GLUT) cross-linking.	ru-aunp	145-152	C-X-C motif chemokine ligand 8	Homo sapiens	157-160
35432787-12	2022	The lowest amounts of metal ions were released in CHX while highest in NaF + alcohol.	Metals	22-27	C-X-C motif chemokine ligand 8	Homo sapiens	71-74
35582294-11	2022	Both EcN and rifaximin produced similar significant reductions in the proinflammatory cytokines INF-gamma, IL-6 and IL-8.	Rifaximin	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
35351947-5	2022	In addition, AM9928 inhibited the secretion of IL-6, IL-8, and VEGF-A from TNBC cells.	3-Pyrroline	13-19	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
35351947-6	2022	TNBC-derived exosomes activated HBMECs resulting in secretion of elevated levels of IL-8 and VEGF, which were inhibited by AM9928.	3-Pyrroline	123-129	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
35387091-4	2022	The administration of TA also inhibited (P < 0.05) the expression of intestinal pro-inflammatory cytokines including interleukin (IL)-1beta, IL-8, interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) but increased (P < 0.05) jejunal IL-10 and secretory immunoglobulin A (sIgA) concentration.	anethole	22-24	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
35328729-6	2022	AGDP not only inhibited the expression of TNF-alpha and IL-8 but also appeared to suppress the extracellular release of high-mobility group box 1 (HMGB1) by inhibiting the output of nuclear HMGB1 in cells.	agdp	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
35273242-6	2022	In contrast, tunicamycin-induced ER stress resulted in increased IL8, CXCL1, and CXCL2 production in cells with knockdown of VCP, while enhanced expression of these proinflammatory molecules was abolished upon knockout of NOD2.	Tunicamycin	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
35184641-7	2022	The TNF-alpha-induced production of interleukin (IL)-6 and IL-8 in HC-A cells were mitigated by butorphanol tartrate.	Butorphanol	96-116	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
35321317-5	2022	In addition, activation of NF-kappaB signaling was involved in VM formation induced by CXCL8, which was blocked by NF-kappaB inhibitors BAY 11-7082 and BMS345541.	3-(4-methylphenylsulfonyl)-2-propenenitrile	136-147	C-X-C motif chemokine ligand 8	Homo sapiens	87-92
35321317-5	2022	In addition, activation of NF-kappaB signaling was involved in VM formation induced by CXCL8, which was blocked by NF-kappaB inhibitors BAY 11-7082 and BMS345541.	4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline	152-161	C-X-C motif chemokine ligand 8	Homo sapiens	87-92
35241635-0	2022	Human endothelial cells promote arsenic-transformed lung epithelial cells to induce tumor growth and angiogenesis through interleukin-8 induction.	Arsenic	32-39	C-X-C motif chemokine ligand 8	Homo sapiens	122-135
35175729-6	2022	The addition of a fluorine-containing additive to a carbonate-based electrolyte, NaClO4 in propylene carbonate (PC):fluoroethylene carbonate (FEC), results in uniform sodium plating processes and much more stable cycling performance, compared to NaClO4 in PC, because of the formation of a stable SEI containing NaF.	Fluorine	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	312-315
35175729-6	2022	The addition of a fluorine-containing additive to a carbonate-based electrolyte, NaClO4 in propylene carbonate (PC):fluoroethylene carbonate (FEC), results in uniform sodium plating processes and much more stable cycling performance, compared to NaClO4 in PC, because of the formation of a stable SEI containing NaF.	sodium perchlorate	81-87	C-X-C motif chemokine ligand 8	Homo sapiens	312-315
35175729-6	2022	The addition of a fluorine-containing additive to a carbonate-based electrolyte, NaClO4 in propylene carbonate (PC):fluoroethylene carbonate (FEC), results in uniform sodium plating processes and much more stable cycling performance, compared to NaClO4 in PC, because of the formation of a stable SEI containing NaF.	propylene carbonate	91-110	C-X-C motif chemokine ligand 8	Homo sapiens	312-315
35175729-6	2022	The addition of a fluorine-containing additive to a carbonate-based electrolyte, NaClO4 in propylene carbonate (PC):fluoroethylene carbonate (FEC), results in uniform sodium plating processes and much more stable cycling performance, compared to NaClO4 in PC, because of the formation of a stable SEI containing NaF.	propylene carbonate	112-114	C-X-C motif chemokine ligand 8	Homo sapiens	312-315
35175729-6	2022	The addition of a fluorine-containing additive to a carbonate-based electrolyte, NaClO4 in propylene carbonate (PC):fluoroethylene carbonate (FEC), results in uniform sodium plating processes and much more stable cycling performance, compared to NaClO4 in PC, because of the formation of a stable SEI containing NaF.	4-fluoro-1,3-dioxolan-2-one	116-140	C-X-C motif chemokine ligand 8	Homo sapiens	312-315
35175729-7	2022	A NaF layer, on top of the sodium metal, leads to a much more uniform deposition of sodium and greatly enhanced cyclability.	Sodium	27-39	C-X-C motif chemokine ligand 8	Homo sapiens	2-5
35175729-7	2022	A NaF layer, on top of the sodium metal, leads to a much more uniform deposition of sodium and greatly enhanced cyclability.	Sodium	84-90	C-X-C motif chemokine ligand 8	Homo sapiens	2-5
35240967-9	2022	PEG-IFN/RIB therapy significantly increased the levels of chemokines, such as IL-8, IP-10, EOTAXIN, MIG, RANTES, and MIP-1beta, in HCV-R, indicating the chemokine response to PEG-IFN/RIB therapy.	peg-ifn	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
34998158-0	2022	The CBL-LSD1-CXCL8 axis regulates methionine metabolism in glioma.	Methionine	34-44	C-X-C motif chemokine ligand 8	Homo sapiens	13-18
34998158-4	2022	The present study found that methionine starvation of glioma cells significantly increased the expression of CXCL8.	Methionine	29-39	C-X-C motif chemokine ligand 8	Homo sapiens	109-114
34998158-6	2022	CXCL8 was found to be involved in regulating the reprogramming of glycerophospholipid metabolism, enabling it to respond to a methionine-deprived environment.	Methionine	126-136	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
34998158-10	2022	Taken together, these findings indicate that the CBL/LSD1/CXCL8 axis is a novel mechanistic connection linking between methionine metabolism, histone methylation and glycerophospholipid reprogramming in the tumor microenvironment.	Methionine	119-129	C-X-C motif chemokine ligand 8	Homo sapiens	58-63
34998158-10	2022	Taken together, these findings indicate that the CBL/LSD1/CXCL8 axis is a novel mechanistic connection linking between methionine metabolism, histone methylation and glycerophospholipid reprogramming in the tumor microenvironment.	Glycerophospholipids	166-185	C-X-C motif chemokine ligand 8	Homo sapiens	58-63
35014682-5	2022	Next, using both reverse transcription-quantitative PCR and ELISA, it was demonstrated that 10Z-Hymenialdisine significantly suppressed the expression of VEGF and IL-8 mRNAs and proteins in pancreatic cancer.	hymenialdisine	92-110	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
35219459-2	2022	OBJECTIVE: This systematic review and meta-analyses aimed to evaluate the potential protective effect of titanium tetrafluoride (TiF4) compound compared to sodium fluoride (NaF) on eroded enamel or dentin.	Sodium Fluoride	156-171	C-X-C motif chemokine ligand 8	Homo sapiens	173-176
35179812-4	2022	The function and integrity of BBB were assessed by measurements of paracellular flux of sodium fluorescein (NaF) and transendothelial electrical resistance (TEER), respectively.	Fluorescein	88-106	C-X-C motif chemokine ligand 8	Homo sapiens	108-111
35082451-5	2022	The order of the salts at pH = 4.0 is exactly reversed: LiCl and NaF show the weakest effect on the cloud-point temperature and the strongest decrease in stability is caused by RbCl and NaNO3.	rubidium chloride	177-181	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
35082451-5	2022	The order of the salts at pH = 4.0 is exactly reversed: LiCl and NaF show the weakest effect on the cloud-point temperature and the strongest decrease in stability is caused by RbCl and NaNO3.	sodium nitrate	186-191	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
35014682-9	2022	In conclusion, the present study demonstrated that 10Z-Hymenialdisine exerted anti-angiogenic effects by suppressing NF-kappaB activity and angiogenic factors, such as VEGF and IL-8, in pancreatic cancer cell lines.	hymenialdisine	51-69	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
35267989-6	2022	Immunoblots showed the differential effects of oligosaccharide compositions in reducing host chemokine interleukin 8 expression and inhibiting of p38 MAP kinase activation.	Oligosaccharides	47-62	C-X-C motif chemokine ligand 8	Homo sapiens	103-116
35424653-0	2022	The corrosion behavior of 304 stainless steel in NaNO3-NaCl-NaF molten salt and vapor.	Stainless Steel	30-45	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
35424653-1	2022	Corrosion behavior of 304 stainless steel in molten NaNO3-NaCl-NaF salt and NaNO3-NaCl-NaF vapor has been studied at 450  C. The results showed that the samples suffered weight loss, and surface oxides, i.e. Fe2O3 and FeCr2O4 characterized by XRD, were formed after corrosion.	Stainless Steel	26-41	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
35424653-2	2022	The surface oxide layer was about 1.1 mum in thickness after corrosion in molten NaNO3-NaCl-NaF salt, which was relatively homogeneous and dense.	Oxides	12-17	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
35424653-4	2022	This is mainly attributed to the existence of NO2 and NO in the molten NaNO3-NaCl-NaF vapor determined by thermogravimetric infrared spectroscopy, which affected the adherence between oxides and the matrix.	Nitrogen Dioxide	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
35424653-4	2022	This is mainly attributed to the existence of NO2 and NO in the molten NaNO3-NaCl-NaF vapor determined by thermogravimetric infrared spectroscopy, which affected the adherence between oxides and the matrix.	Oxides	184-190	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
35424653-5	2022	Additionally, the corrosion rate of 304 stainless steel in molten NaNO3-NaCl-NaF salt is almost close to that in solar salt, which demonstrates that the synergy influence of Cl- and F- on the rate of 304 stainless steel is not significant.	Stainless Steel	40-55	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
35226681-1	2022	INTRODUCTION: Sodium fluoride (NaF) tubes are the recommended tubes for glucose measurements, but these are expensive, have limited number of uses, and are not always available in low resource settings.	Sodium Fluoride	14-29	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
35226681-1	2022	INTRODUCTION: Sodium fluoride (NaF) tubes are the recommended tubes for glucose measurements, but these are expensive, have limited number of uses, and are not always available in low resource settings.	Glucose	72-79	C-X-C motif chemokine ligand 8	Homo sapiens	31-34
35226681-6	2022	RESULTS: Rapid decline in glucose concentrations was observed when compared to baseline in serum (declined to 64%) and EDTA-plasma (declined to 77%) after 6 hours when samples were un-centrifuged at room temperature whilst NaF-plasma was stable after 24 hours in the same condition.	Glucose	26-33	C-X-C motif chemokine ligand 8	Homo sapiens	223-226
35168236-1	2022	This study evaluated the combination of a sugarcane cystatin (CaneCPI-5) and sodium fluoride (NaF) in acquired pellicle engineering for the prevention of dental erosion in vitro.	Sodium Fluoride	77-92	C-X-C motif chemokine ligand 8	Homo sapiens	94-97
35268019-4	2022	We determined whether RGE suppresses the expression of IL-8 via Nrf2 activation and the expression of SOD and HO-1 in H. pylori-infected gastric epithelial AGS cells.	(2s)-2-Amino-5-(2-(Methylsulfinyl)acetimidamido)pentanoic Acid	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
35182412-3	2022	TNFalpha caused an increase in interleukin (IL)-6 and IL-8 release which was inhibited by curcumin in a dose-dependent manner (IC50 = 3.4 muM for IL-6).	Curcumin	90-98	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
35252240-3	2022	The radionuclide 18F-sodium fluoride (NaF) has historically been used as a bone imaging probe due to its high sensitivity for targeting hydroxyapatite and bone turnover, but has not been applied in the context of CN.	Radioisotopes	4-16	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
35252240-3	2022	The radionuclide 18F-sodium fluoride (NaF) has historically been used as a bone imaging probe due to its high sensitivity for targeting hydroxyapatite and bone turnover, but has not been applied in the context of CN.	18f-sodium fluoride	17-36	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
35252240-3	2022	The radionuclide 18F-sodium fluoride (NaF) has historically been used as a bone imaging probe due to its high sensitivity for targeting hydroxyapatite and bone turnover, but has not been applied in the context of CN.	Durapatite	136-150	C-X-C motif chemokine ligand 8	Homo sapiens	38-41
35188323-8	2022	MtROS reduction inhibited IL-1beta and IL-8 secretions by NLRP3/caspase-1/IL-1beta/IL-8 pathway.	mtros	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
35188323-8	2022	MtROS reduction inhibited IL-1beta and IL-8 secretions by NLRP3/caspase-1/IL-1beta/IL-8 pathway.	mtros	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	83-87
35204307-8	2022	The expression of pro-inflammatory cytokines, including interleukin (IL)-1beta, IL-6, and IL-8, was also suppressed by 3,5,7-trimethoxyflavone (6).	3,5,7-Trimethoxyflavone	119-142	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
35168647-4	2022	One, 10 and 100 muM triamcinolone induced significant decrease in the production of IL-6 and IL-8 at 48, 72 and 96 h, adding the time point 12 h for IL-8.	Triamcinolone	20-33	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
35168647-4	2022	One, 10 and 100 muM triamcinolone induced significant decrease in the production of IL-6 and IL-8 at 48, 72 and 96 h, adding the time point 12 h for IL-8.	Triamcinolone	20-33	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
34982964-13	2022	Especially, javamide-I ester inhibited TNF-alpha, MCP-1, IL-1beta and IL-8 with IC50 values of 1.79, 0.88, 0.91 and 2.57 muM in PBMCs.	javamide-i ester	12-28	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
35168647-7	2022	While triamcinolone inhibited the production of IL-6 and IL-8 by LEE cells, PRP induced an increase in these cytokines compared with controls.	Triamcinolone	6-19	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
35216142-11	2022	Preliminary in vitro tests showed that this enzymatically synthesized prodrug of ibuprofen reduced the expression of the interleukin 8 genes in human bronchial epithelial cells (IB3-1) from cystic fibrosis (CF) patients.	Ibuprofen	81-90	C-X-C motif chemokine ligand 8	Homo sapiens	121-134
35215330-0	2022	Carbocysteine Modifies Circulating miR-21, IL-8, sRAGE, and fAGEs Levels in Mild Acute Exacerbated COPD Patients: A Pilot Study.	Carbocysteine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
35215330-10	2022	Carbocysteine improved symptoms, FEV1 and FEF25-75%, increased sRAGE, and reduced miR-21, IL-8, and fAGEs in mild AECOPD patients.	Carbocysteine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
35142984-2	2022	METHODS: 18F-sodium fluoride-positron-emission-tomography (18F-NaF-PET) was used to perform quantitative analysis of the bone metabolism in various parts.	18f-sodium fluoride	9-28	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
35216080-8	2022	Moreover, IL-8 production was involved in the LPA response via the activation of the Ca2+-dependent transcriptional factor nuclear factor of activated T cells.	lysophosphatidic acid	46-49	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
35141934-12	2022	Finally, AA attenuated LPS- or LTA-induced cytokine production of IL-1ss, IL-6, IL-8, and TNF.	lipoteichoic acid	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
35135482-7	2022	RESULTS: TCS and CCS, as compared to controls, had 1.44 (95%CI 1.06-1.96) and 1.25 (95 CI 1.02-1.53) times higher levels of IL-8, respectively.	Technetium	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
35114024-10	2022	In vitro exposure of HBECs to HDM furthermore reduced anti-microbial responses to Poly(I:C) including beta-defensin-2, IL-8, and TNF- , along with reduced NF-kappaB activity.	poly	82-86	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
35123563-8	2022	Mechanistically, we found that Ricolinostat enhanced MkP fate mainly by inhibiting the secretion of IL-8 and decreasing the expression of the IL-8 receptor CXCR2.	ricolinostat	31-43	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
35123563-9	2022	CONCLUSION: The addition of Ricolinostat to the culture medium promoted MkP differentiation from HSPCs and enhanced the proliferation of MkPs mainly by suppressing the IL-8/CXCR2 pathway.	ricolinostat	28-40	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
35112925-9	2022	At the functional level, we found that SOANAP-SP augmented the secretion of malondialdehyde and interleukin-8 and may have induced the activation of endothelial cells in the coculture system.	soanap-sp	39-48	C-X-C motif chemokine ligand 8	Homo sapiens	96-109
35185902-9	2022	On the other hand, inhibition of NOX-associated ROS production decreased virus replication and cell death, as well as the secretion of inflammatory cytokines, including IL-6, IL-8, and CCL5.	Reactive Oxygen Species	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
35197758-5	2022	Based on the in-silico structure-assisted drug designing involving molecular docking, MD simulations, and MMPBSA analyses, we found a small molecule ZINC14613097 inhibits IL8.	zinc14613097	149-161	C-X-C motif chemokine ligand 8	Homo sapiens	171-174
35044539-7	2022	We have discussed various sources of interleukin (IL)-8 secretion and the possible association of IL8-fibroblast plasticity as a cause of nonhealing DFUs.	dfus	149-153	C-X-C motif chemokine ligand 8	Homo sapiens	98-101
35163449-6	2022	The O-2-substituted (1-3)-beta-D-glucan modulated production and expression of IL-8 and the IL-10 in Caco-2 and PMA-THP-1 cells.	o-2-substituted (1-3)-beta-d-glucan	4-39	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
34818666-4	2022	IVSK reduced the secretion of inflammatory mediators, interleukin (IL)-8 and monocyte chemoattractant protein-1 (MCP-1) and the mRNA expression of IL-6, IL-8, MCP-1 and IL-1beta.	ivsk	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	54-72
35173714-6	2022	However, ATRA attenuated TGEV-induced inflammatory response by inhibiting the release of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-8 and TNF-alpha.	Tretinoin	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
35215890-8	2022	Additionally, the results show that the NF-kappaB inhibitor BAY11-7082 can inhibit the replication of ASFV and can inhibit IL-1beta and, IL-8 expression.	3-(4-methylphenylsulfonyl)-2-propenenitrile	60-70	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
34099595-7	2022	LUA treatment dramatically reduced LPS-stimulated reactive oxygen species (ROS) and mRNA levels of pro-inflammatory mediators such as IL-1beta, IL-6, IL-8 and IFN-beta.	lua	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
34818666-4	2022	IVSK reduced the secretion of inflammatory mediators, interleukin (IL)-8 and monocyte chemoattractant protein-1 (MCP-1) and the mRNA expression of IL-6, IL-8, MCP-1 and IL-1beta.	ivsk	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
35072213-6	2022	RESULTS: Azithromycin decreased the secretion of interleukin (IL) 4, IL-5, IL-13, and IL-17A from PBMCs, as well as the production of IL-4 and IL-8 by CD4+ and CD8+ T cells.	Azithromycin	9-21	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
35164046-6	2022	In addition, the inhibitory effects of both doses of MiodesinTM (10 microg/mL and 200 microg/mL) resulted in reduced secretion of interleukin-1beta (IL-1beta), IL-6, IL-8, tumor necrosis factor alpha (TNF-alpha) (24 h, 48 h, and 72 h) and CCL2, CCL3, and CLL5 (p < 0.05) by VK2 E6/E7 cells.	miodesintm	53-63	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
35164046-7	2022	In the same way, COX-1 MiodesinTM inhibited LPS-induced hyperactivation of KLE cells, as demonstrated by reduced secretion of IL-1beta, IL-6, IL-8, TNF-alpha (24 h, 48 h, and 72 h) and CCL2, CCL3, and CLL5 (p < 0.05).	miodesintm	23-33	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
35155394-4	2022	We engineered a model lactic acid bacterium, Lactococcus lactis, to co-display on its surface a protein ligand for tumor antigens (EpCAM-binding affitin; HER2-binding affibody) and a ligand for pro-inflammatory cytokines (IL-8-binding evasin; IL-6-binding affibody).	Lactic Acid	22-33	C-X-C motif chemokine ligand 8	Homo sapiens	222-226
35072213-7	2022	The combination of azithromycin and budesonide suppressed inflammatory response by inhibition of IL-4, IL-5, IL-8, IL-13, IL-17A, IL-33, thymic stromal lymphopoietin (TSLP), macrophage migration inhibitory factor (MIF) release from PBMCs and by reduction of the percentage of IL-4-, IL-8-, interferon gamma- and tumor necrosis factor a-expressing CD4+ and CD8+ T cells.	Azithromycin	19-31	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
35072213-7	2022	The combination of azithromycin and budesonide suppressed inflammatory response by inhibition of IL-4, IL-5, IL-8, IL-13, IL-17A, IL-33, thymic stromal lymphopoietin (TSLP), macrophage migration inhibitory factor (MIF) release from PBMCs and by reduction of the percentage of IL-4-, IL-8-, interferon gamma- and tumor necrosis factor a-expressing CD4+ and CD8+ T cells.	Budesonide	36-46	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
35072213-8	2022	The inhibitory effect of azithromycin combined with budesonide on IL-4, IL-5, IL-8, IL-17A, TSLP production by PBMCs, as well as IL-4 and IL-8 production by T helper cells and cytotoxic T lymphocytes was significantly greater than the effect of budesonide alone.	Azithromycin	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
35048417-6	2022	Analysis of cell culture medium of rifampicin treated HS explants revealed an anti-inflammatory effect of rifampicin that significantly inhibiting interleukin (IL)-1beta, IL-6, IL-8, IL-10, and tumour necrosis factor (TNF) -alpha production.	Rifampin	106-116	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
35072213-8	2022	The inhibitory effect of azithromycin combined with budesonide on IL-4, IL-5, IL-8, IL-17A, TSLP production by PBMCs, as well as IL-4 and IL-8 production by T helper cells and cytotoxic T lymphocytes was significantly greater than the effect of budesonide alone.	Azithromycin	25-37	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
35072213-8	2022	The inhibitory effect of azithromycin combined with budesonide on IL-4, IL-5, IL-8, IL-17A, TSLP production by PBMCs, as well as IL-4 and IL-8 production by T helper cells and cytotoxic T lymphocytes was significantly greater than the effect of budesonide alone.	Budesonide	52-62	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
35204104-6	2022	In addition, HC-EA, quercitrin, and hyperoside attenuated UVB-induced inflammatory mediators, including IL-6, IL-8, COX-2, and iNOS.	hc-ea	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
35204104-6	2022	In addition, HC-EA, quercitrin, and hyperoside attenuated UVB-induced inflammatory mediators, including IL-6, IL-8, COX-2, and iNOS.	quercitrin	20-30	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
35276864-4	2022	The levels of pro-inflammatory cytokines, IL-6, IL-8, ENA-78, and GCP-2 were decreased in a carvacrol dose-dependent manner.	carvacrol	92-101	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
35163066-4	2022	In the present study, we demonstrated, by using both primary epidermal keratinocytes (NHEK) and a 3D epidermis model, that paclitaxel impairs different cellular processes: paclitaxel increased the release of IL-1alpha, IL-6, and IL-8 inflammatory cytokines, produced reactive oxygen species (ROS) release and apoptosis, and reduced the endothelial tube formation in the dermal microvascular endothelial cells (HDMEC).	Paclitaxel	123-133	C-X-C motif chemokine ligand 8	Homo sapiens	229-233
35127774-7	2021	Levels of acute phase reactant SAA and IL-6 decreased significantly after treatment with GC and leflunomide, while levels of IL-8, IL-18, and CHI3L1 did not change significantly during the follow-up period.	Leflunomide	96-107	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
35055148-0	2022	Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues.	Sodium Fluoride	22-37	C-X-C motif chemokine ligand 8	Homo sapiens	39-42
35154692-7	2022	In this study, we found that acetate, propionate, and butyrate decreased IL-1beta-induced production of CXCL2 ex vivo and IL-8 and IL-6 in vitro significantly (p < .05).	Acetates	29-36	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
35154692-7	2022	In this study, we found that acetate, propionate, and butyrate decreased IL-1beta-induced production of CXCL2 ex vivo and IL-8 and IL-6 in vitro significantly (p < .05).	Propionates	38-48	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
35154692-7	2022	In this study, we found that acetate, propionate, and butyrate decreased IL-1beta-induced production of CXCL2 ex vivo and IL-8 and IL-6 in vitro significantly (p < .05).	Butyrates	54-62	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
35163066-4	2022	In the present study, we demonstrated, by using both primary epidermal keratinocytes (NHEK) and a 3D epidermis model, that paclitaxel impairs different cellular processes: paclitaxel increased the release of IL-1alpha, IL-6, and IL-8 inflammatory cytokines, produced reactive oxygen species (ROS) release and apoptosis, and reduced the endothelial tube formation in the dermal microvascular endothelial cells (HDMEC).	Paclitaxel	172-182	C-X-C motif chemokine ligand 8	Homo sapiens	229-233
35237424-8	2022	A 6 h pretreatment of 3-MA increased PM2.5-induced oxidative damage and cellular inflammation as indicated by increasing protein levels of HO-1, TXNIP, Bnip3L/NIX and IL-8 gene expression.	3-methyladenine	22-26	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
35055148-1	2022	Sodium fluoride (NaF) is widely used in clinical dentistry.	Sodium Fluoride	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	17-20
35280694-5	2022	The activation of Stat3 induced the secretion of glutamic acid-leucine-arginine (ELR) motif CXCLs (CXCL1, CXCL2, CXCL3 and CXCL8) in tumor cells.	Leucine	63-70	C-X-C motif chemokine ligand 8	Homo sapiens	123-128
35055148-4	2022	Studies of NaF and epithelial cells, osteoblasts, osteoclasts, and periodontal cells have suggested the significant roles of fluoride treatment.	Fluorides	125-133	C-X-C motif chemokine ligand 8	Homo sapiens	11-14
35280694-5	2022	The activation of Stat3 induced the secretion of glutamic acid-leucine-arginine (ELR) motif CXCLs (CXCL1, CXCL2, CXCL3 and CXCL8) in tumor cells.	elr	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	123-128
35054486-7	2022	Moreover, we demonstrated that IL-8 could activate both AKT and ERK1/2 via CXCR1 to confer tamoxifen resistance.	Tamoxifen	91-100	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
35096851-1	2021	The aim of the study was to assess the quality and reproducibility of reducing the injected (18F) sodium fluoride ((18F)NaF) dose while maintaining diagnostic imaging quality in bone imaging in a preclinical skeletal model using digital photon counting PET (dPET) detector technology.	Sodium Fluoride	98-113	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
35082667-11	2021	PIASCLEDINE-ExpASU  was the most active of the tested ASU products in inhibiting nitric oxide, IL-6, and IL-8 production by chondrocytes.	piascledine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	105-109
35054995-6	2022	The levels of IL-6 and IL-8 in HGFs were higher when the cells were treated with EBV than when treated with lipopolysaccharide and lipoteichoic acid.	lipoteichoic acid	131-148	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
35435039-10	2022	This coincided with 3.2-fold lower area under the concentration time curve (AUC) of IL-8 from day -3 to day 14 in curcumin group compared with control group (P = 0.039).	Curcumin	114-122	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
35052454-5	2022	We found that increased genetically proxied morning cortisol levels were associated with reduced levels of IL-8 and increased levels of MIF.	Hydrocortisone	52-60	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
35052454-7	2022	Clinically, our findings underline the therapeutic importance of steroids in inflammatory conditions where IL-8 and MIF play a central pathophysiological role in the onset and progression of disease.	Steroids	65-73	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
35047008-8	2021	Results: A total of 1,373 DEGs in GSE8056 were obtained, and the top 5 upregulated genes were S100A12, CXCL8, CXCL5, MMP3, and MMP1, whereas the top 5 downregulated genes were SCGB1D2, SCGB2A2, DCD, TSPAN8, and KRT25.	gse8056	34-41	C-X-C motif chemokine ligand 8	Homo sapiens	103-108
34967261-8	2022	Sitagliptin inhibited HG-induced production of pro-inflammatory cytokines interleukin-1beta (IL-1beta) and interleukin-8 (IL-8) in HrGECs.	Sitagliptin Phosphate	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	107-120
34967261-8	2022	Sitagliptin inhibited HG-induced production of pro-inflammatory cytokines interleukin-1beta (IL-1beta) and interleukin-8 (IL-8) in HrGECs.	Sitagliptin Phosphate	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
34967261-8	2022	Sitagliptin inhibited HG-induced production of pro-inflammatory cytokines interleukin-1beta (IL-1beta) and interleukin-8 (IL-8) in HrGECs.	Mercury	22-24	C-X-C motif chemokine ligand 8	Homo sapiens	107-120
34967261-8	2022	Sitagliptin inhibited HG-induced production of pro-inflammatory cytokines interleukin-1beta (IL-1beta) and interleukin-8 (IL-8) in HrGECs.	Mercury	22-24	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
35054486-9	2022	In conclusion, BQ overexpression in ER+ve breast cancer can enhance IL-8 mediated signaling to modulate tamoxifen resistance.	Tamoxifen	104-113	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
35054486-10	2022	Targeting IL-8 signaling is a promising approach to overcome tamoxifen resistance in ER+ve breast cancer.	Tamoxifen	61-70	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
34983106-5	2022	In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs.	Poly C	23-41	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
34983106-5	2022	In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs.	Poly I-C	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
35435039-11	2022	We conclude that curcumin mitigates toxicities of high-dose melphalan, possibly through IL-8 modulation.	Curcumin	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
35435039-11	2022	We conclude that curcumin mitigates toxicities of high-dose melphalan, possibly through IL-8 modulation.	Melphalan	60-69	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
35388712-10	2022	Furthermore, Y-27632 decreased the CD73, CD90, CD105, CD166, TLR4, and NF-kappaB p65 genes expression, but increased the IL-8 gene expression.	Y 27632	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
35021171-3	2022	This study compares the efficacy of a PB mouthrinse with 0.12% chlorhexidine (CHX) and 0.05% sodium fluoride (NaF) mouthrinse on the colony counts of mutans streptococci (MS) in children.	Sodium Fluoride	93-108	C-X-C motif chemokine ligand 8	Homo sapiens	110-113
34887371-1	2022	OBJECTIVES: An earlier study demonstrated comparable lesion detection between attenuation-corrected (AC) and nonattenuation-corrected (NAC) 18F-sodium fluoride (NaF) PET images, which is relevant for computed tomography (CT) radiation dose-saving.	nac	135-138	C-X-C motif chemokine ligand 8	Homo sapiens	161-164
34887371-1	2022	OBJECTIVES: An earlier study demonstrated comparable lesion detection between attenuation-corrected (AC) and nonattenuation-corrected (NAC) 18F-sodium fluoride (NaF) PET images, which is relevant for computed tomography (CT) radiation dose-saving.	18f-sodium fluoride	140-159	C-X-C motif chemokine ligand 8	Homo sapiens	161-164
34887371-3	2022	The aim was to compare lesion detection between AC and NAC NaF PET images on modern PET-CT systems.	nac	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	59-62
35101686-10	2022	In addition, ICV L-Cit potentiated a pro- versus anti-inflammatory milieu with the induction of IL-8, IL-10, and TGFbeta (P < 0.05), which may be related to the changes in body temperature.	Citrulline	17-22	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
35124112-6	2022	The optimum NaF concentration (14 mM) resulted in an over 1000-fold enhancement in dTAT complexes (N/P 33) transfection efficiency.	dtat	83-87	C-X-C motif chemokine ligand 8	Homo sapiens	12-15