PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
21531761-2	2011	The antihelminth compound niclosamide downregulates components of the Wnt pathway, specifically Dishevelled-2 (Dvl2) expression, resulting in diminished downstream beta-catenin signaling.	Niclosamide	26-37	dishevelled segment polarity protein 2	Homo sapiens	96-109
21531761-2	2011	The antihelminth compound niclosamide downregulates components of the Wnt pathway, specifically Dishevelled-2 (Dvl2) expression, resulting in diminished downstream beta-catenin signaling.	Niclosamide	26-37	dishevelled segment polarity protein 2	Homo sapiens	111-115
21531761-4	2011	We found that niclosamide inhibited Wnt/beta-catenin pathway activation, downregulated Dvl2, decreased downstream beta-catenin signaling, and exerted antiproliferative effects in human colon cancer cell lines and CRC cells isolated by surgical resection of metastatic disease, regardless of mutations in APC.	Niclosamide	14-25	dishevelled segment polarity protein 2	Homo sapiens	87-91
21477044-3	2011	Western blotting revealed increases in phosphorylated Akt (pAkt) and phosphorylated glycogen synthase kinase-3 (pGSK-3) following acute and repeated treatment of LY379268 (mGlu(2/3) agonist), whereas increases in dishevelled-2 (Dvl-2), dishevelled-3 (Dvl-3), GSK-3 and beta-catenin were only observed following repeated treatment.	LY 379268	162-170	dishevelled segment polarity protein 2	Homo sapiens	213-226
21477044-3	2011	Western blotting revealed increases in phosphorylated Akt (pAkt) and phosphorylated glycogen synthase kinase-3 (pGSK-3) following acute and repeated treatment of LY379268 (mGlu(2/3) agonist), whereas increases in dishevelled-2 (Dvl-2), dishevelled-3 (Dvl-3), GSK-3 and beta-catenin were only observed following repeated treatment.	LY 379268	162-170	dishevelled segment polarity protein 2	Homo sapiens	228-233
17390078-8	2007	There was also an increase in c-kit, Trio, Rho-A, Rac-3, EGFR, Notch-4, Dvl-2, Ezrin, beta catenin and mutant p53 protein expression in the parathion-treated cells.	Parathion	140-149	dishevelled segment polarity protein 2	Homo sapiens	72-77
21691068-5	2011	We further demonstrated that GABARAPL1 mediates degradation of Dvl2 and the effect is blocked by addition of 3-MA, a specific inhibitor of autophagy.	3-methyladenine	109-113	dishevelled segment polarity protein 2	Homo sapiens	63-67
20947020-3	2010	Our previous work has shown that Dvl2 links at least one Frizzled family member (Fz4) to clathrin-mediated endocytosis by interacting with the mu2 subunit of the AP-2 clathrin adaptor, through both a classical endocytic tyrosine motif and a so-called "DEP domain."	Tyrosine	220-228	dishevelled segment polarity protein 2	Homo sapiens	33-37
20947020-7	2010	Mutation of residues at the DEP-mu2 contact or in the tyrosine motif reduce affinity of Dvl2 for mu2 and block efficient internalization of Fz4 in response to ligation by Wnt5a.	Tyrosine	54-62	dishevelled segment polarity protein 2	Homo sapiens	88-92
20176724-0	2010	Dehydroepiandrosterone administration or G{alpha}q overexpression induces {beta}-catenin/T-Cell factor signaling and growth via increasing association of estrogen receptor-{beta}/Dishevelled2 in androgen-independent prostate cancer cells.	Dehydroepiandrosterone	0-22	dishevelled segment polarity protein 2	Homo sapiens	179-191
20176724-4	2010	We now report that DHEA induces beta-CTS via increasing association of estrogen receptor (ER)-beta with Dishevelled2 (Dvl2) in AR nonresponsive human PrCa DU145 cells, a line of androgen-independent PrCa (AiPC) cells.	Dehydroepiandrosterone	19-23	dishevelled segment polarity protein 2	Homo sapiens	104-116
20176724-4	2010	We now report that DHEA induces beta-CTS via increasing association of estrogen receptor (ER)-beta with Dishevelled2 (Dvl2) in AR nonresponsive human PrCa DU145 cells, a line of androgen-independent PrCa (AiPC) cells.	Dehydroepiandrosterone	19-23	dishevelled segment polarity protein 2	Homo sapiens	118-122
20176724-4	2010	We now report that DHEA induces beta-CTS via increasing association of estrogen receptor (ER)-beta with Dishevelled2 (Dvl2) in AR nonresponsive human PrCa DU145 cells, a line of androgen-independent PrCa (AiPC) cells.	beta-cts	32-40	dishevelled segment polarity protein 2	Homo sapiens	118-122
20823832-4	2010	When cells were treated with nocodazole, Dvl2 was observed at the kinetochores (KTs).	Nocodazole	29-39	dishevelled segment polarity protein 2	Homo sapiens	41-45
34589148-11	2021	In conclusion the findings of the present study suggested that DVL2 may be a potential therapeutic target in the treatment of PDAC.	pdac	126-130	dishevelled segment polarity protein 2	Homo sapiens	63-67
31340145-5	2019	We propose that a WWP1-USP9X axis regulates a ubiquitin rheostat on DVL2 that specifies its participation in either canonical WNT or WNT-PCP pathways.	pcp	137-140	dishevelled segment polarity protein 2	Homo sapiens	68-72
32588988-7	2020	RESULTS: We found that the expression levels of DVL2 (OMIM accession number: 602151) and DVL3 (OMIM accession number: 601368) were upregulated in HCC tissues as revealed by the Oncomine and HCCDB databases.	oncomine	177-185	dishevelled segment polarity protein 2	Homo sapiens	48-52
32588988-7	2020	RESULTS: We found that the expression levels of DVL2 (OMIM accession number: 602151) and DVL3 (OMIM accession number: 601368) were upregulated in HCC tissues as revealed by the Oncomine and HCCDB databases.	hccdb	190-195	dishevelled segment polarity protein 2	Homo sapiens	48-52
32201078-3	2020	In addition, we found that Echinacoside can dose-dependently reduce phosho-LRP6, total LRP6, phosho-Dvl2, active beta-catenin, and total beta-catenin protein expression level in MDA-MB-231 and MDA-MB-468 cells by western blot.	echinacoside	27-39	dishevelled segment polarity protein 2	Homo sapiens	100-104
32015160-6	2020	In breast cancer cells, treatment with CDDO-Me increased the degradation of LRP6 and Fzd7, reduced the levels of phosphorylated DVL2 and active beta-catenin, resulting in downregulation of Wnt target genes and some cancer stem cell (CSC) marker genes.	bardoxolone methyl	39-46	dishevelled segment polarity protein 2	Homo sapiens	128-132
32015160-7	2020	In a murine xenograft bearing MMTV-Wnt1-driven mammary tumor, administration of CDDO-Me significantly inhibited tumor growth, accompanied by reduced expression of phosphorylated and total LRP6, phosphorylated and unphosphorylated DVL2, active beta-catenin, several Wnt target genes and CSC marker genes.	bardoxolone methyl	80-87	dishevelled segment polarity protein 2	Homo sapiens	230-234
31579410-10	2019	Furthermore, levels of p-DVL-2Ser143 and major Wnt-signaling proteins decreased significantly after treatment of A549/DDP cells with CX4945+cisplatin, whereas DVL-2 and p-DVL-2Thr224 levels remained unchanged.	Cisplatin	140-149	dishevelled segment polarity protein 2	Homo sapiens	25-30
35509083-13	2022	CONCLUSIONS: These results provide novel insight into the role of CYP2E1 in HCC and the tumor suppressor role of CYP2E1 can be attributed to its ability to manipulate Wnt/Dvl2/beta-catenin pathway via inducing ROS accumulation, which provides a potential target for the prevention and treatment of HCC.	Reactive Oxygen Species	210-213	dishevelled segment polarity protein 2	Homo sapiens	171-175
32092816-2	2020	It has been shown to mediate numerous pathophysiological processes, including the regulation of synaptic plasticity and Wnt-associated signaling, via promoting the ubiquitination of its substrates, such as cyclic adenosine monophosphate (cAMP)-response element binding protein regulated transcription coactivator 3 (CRTC3), alpha-amino-3-hydroxy-5-methyl-4-isoxazo-lepropionic acid receptor (AMPAR), and Dishevelled2 (Dvl2).	Adenosine	213-222	dishevelled segment polarity protein 2	Homo sapiens	404-416
32092816-2	2020	It has been shown to mediate numerous pathophysiological processes, including the regulation of synaptic plasticity and Wnt-associated signaling, via promoting the ubiquitination of its substrates, such as cyclic adenosine monophosphate (cAMP)-response element binding protein regulated transcription coactivator 3 (CRTC3), alpha-amino-3-hydroxy-5-methyl-4-isoxazo-lepropionic acid receptor (AMPAR), and Dishevelled2 (Dvl2).	Adenosine	213-222	dishevelled segment polarity protein 2	Homo sapiens	418-422
32092816-2	2020	It has been shown to mediate numerous pathophysiological processes, including the regulation of synaptic plasticity and Wnt-associated signaling, via promoting the ubiquitination of its substrates, such as cyclic adenosine monophosphate (cAMP)-response element binding protein regulated transcription coactivator 3 (CRTC3), alpha-amino-3-hydroxy-5-methyl-4-isoxazo-lepropionic acid receptor (AMPAR), and Dishevelled2 (Dvl2).	Cyclic AMP	238-242	dishevelled segment polarity protein 2	Homo sapiens	404-416
32092816-2	2020	It has been shown to mediate numerous pathophysiological processes, including the regulation of synaptic plasticity and Wnt-associated signaling, via promoting the ubiquitination of its substrates, such as cyclic adenosine monophosphate (cAMP)-response element binding protein regulated transcription coactivator 3 (CRTC3), alpha-amino-3-hydroxy-5-methyl-4-isoxazo-lepropionic acid receptor (AMPAR), and Dishevelled2 (Dvl2).	Cyclic AMP	238-242	dishevelled segment polarity protein 2	Homo sapiens	418-422
31618172-3	2019	OBJECTIVE: This study mainly aimed to clarify whether the Dvl2 and Axin-DIX domains (Dvl2-DIX and Axin-DIX, respectively) form a helical polymer in a head-to-tail way during complexation.	Polymers	137-144	dishevelled segment polarity protein 2	Homo sapiens	58-62
29515783-6	2018	Taken together, our data suggest that HMGA2 enhances the chemoresistance to 5-FU in CRC via activating the Dvl2/Wnt pathway.	Fluorouracil	76-80	dishevelled segment polarity protein 2	Homo sapiens	107-111
30717563-7	2018	The results of Western blot showed that orchinol could significantly down-regulate the protein expression levels of beta-catenin, Wnt3a, DvL2 and cyclinD1, and up-regulate the protein expression level of GSK-3beta(P<0.05, P<0.01, P<0.001).	orchinol	40-48	dishevelled segment polarity protein 2	Homo sapiens	137-141
30143678-3	2018	We also showed that niclosamide effectively inhibits activation of the Wnt/beta-catenin signaling pathway by targeting multiple components of this pathway, including downregulating the expression beta-catenin, Dishevelled 2 (DVL2), phosphorylated glycogen synthase kinase-3beta (p-GSK3beta) and Cyclin D1, in human OSCC SCC4 and SCC25 cell lines, as well as reduced the formation of primary and secondary tumorspheres.	Niclosamide	20-31	dishevelled segment polarity protein 2	Homo sapiens	210-223
30143678-3	2018	We also showed that niclosamide effectively inhibits activation of the Wnt/beta-catenin signaling pathway by targeting multiple components of this pathway, including downregulating the expression beta-catenin, Dishevelled 2 (DVL2), phosphorylated glycogen synthase kinase-3beta (p-GSK3beta) and Cyclin D1, in human OSCC SCC4 and SCC25 cell lines, as well as reduced the formation of primary and secondary tumorspheres.	Niclosamide	20-31	dishevelled segment polarity protein 2	Homo sapiens	225-229
29749449-7	2018	In addition, the depletion of Dvl-2 also significantly inhibited the expression of runt-related transcription factor 2 (Runx-2) and beta-catenin in SFBs (P<0.05).	N-succinimidyl 8-((4'-fluorobenzyl)amino)suberate	148-152	dishevelled segment polarity protein 2	Homo sapiens	30-35
29749449-10	2018	In conclusion, the results indicate that Dvl-2 regulated osteogenic differentiation of SFBs in OA.	N-succinimidyl 8-((4'-fluorobenzyl)amino)suberate	87-91	dishevelled segment polarity protein 2	Homo sapiens	41-46
29796181-6	2018	In RPGR, RPGRIP1 or RPGRIP1L KD cells, we observed increased levels of DVl2 and DVl3 proteins, the core components of the PCP pathway, due to impaired proteasomal activity.	pcp	122-125	dishevelled segment polarity protein 2	Homo sapiens	71-75
29414668-10	2018	In the same assay, garcinol down-regulated beta-catenin, Dvl2, Axin2, and cyclin D1 expressions in NSCLC-generated spheres, suggesting its ability to regulate the Wnt/beta-catenin signaling pathway.	garcinol	19-27	dishevelled segment polarity protein 2	Homo sapiens	57-61
29690734-4	2018	Results: Compared with the control group, DVL2 significantly increased the apoptosis rate of MH7A (3.2%+-2.2% vs 25.7%+-4.5%).	mh7a	93-97	dishevelled segment polarity protein 2	Homo sapiens	42-46
28861168-6	2017	We also demonstrated that niclosamide specifically suppresses the levels of p-LRP6, Dvl2, and beta-catenin, but not p-STAT3, in Y79 cells.	Niclosamide	26-37	dishevelled segment polarity protein 2	Homo sapiens	84-88
28800883-8	2017	In addition, Western blot analysis demonstrated that Jaridon 6 regulated the expression of Wnt pathway proteins, including reduced levels of Dvl 2, survivin and cyclin D1, and increased levels of p-beta-catenin, and AXIN2 in EC109 and EC9706 esophageal cancer cells.	jaridon 6	53-62	dishevelled segment polarity protein 2	Homo sapiens	141-146
28614913-0	2017	The Fungal Metabolite Brefeldin A Inhibits Dvl2-Plk1-Dependent Primary Cilium Disassembly.	Brefeldin A	22-33	dishevelled segment polarity protein 2	Homo sapiens	43-47
28614913-5	2017	Among them, the application of KY-0120, identified as Brefeldin A, disturbed Dvl2-Plk1-mediated cilium disassembly via repression of the interaction of CK1e-Dvl2 and the expression of Plk1 mRNA.	K-Y jelly	31-33	dishevelled segment polarity protein 2	Homo sapiens	77-81
28614913-5	2017	Among them, the application of KY-0120, identified as Brefeldin A, disturbed Dvl2-Plk1-mediated cilium disassembly via repression of the interaction of CK1e-Dvl2 and the expression of Plk1 mRNA.	K-Y jelly	31-33	dishevelled segment polarity protein 2	Homo sapiens	157-161
27799526-5	2016	In breast cancer MDA-MB-231 and MDA-MB-468 cells, nanomolar concentrations of prodigiosin decreased phosphorylation of LRP6, DVL2, and GSK3beta and suppressed beta-catenin-stimulated Wnt target gene expression, including expression of cyclin D1.	Prodigiosin	78-89	dishevelled segment polarity protein 2	Homo sapiens	125-129
27432651-4	2016	Here, we found that DVL2 was over-expressed in cisplatin-resistant human lung cancer cells A549/CDDP compared to the parental A549 cells.	Cisplatin	47-56	dishevelled segment polarity protein 2	Homo sapiens	20-24
27432651-4	2016	Here, we found that DVL2 was over-expressed in cisplatin-resistant human lung cancer cells A549/CDDP compared to the parental A549 cells.	Cisplatin	96-100	dishevelled segment polarity protein 2	Homo sapiens	20-24
27432651-5	2016	Inhibition of DVL2 by its inhibitor (3289-8625) or shDVL2 resensitized A549/CDDP cells to cisplatin.	Cisplatin	90-99	dishevelled segment polarity protein 2	Homo sapiens	14-18
27432651-7	2016	In addition, shbeta-catenin abolished the DVL2-induced the expression of BCRP, MRP4, and Survivin.	shbeta-catenin	13-27	dishevelled segment polarity protein 2	Homo sapiens	42-46
27432651-9	2016	Taken together, these results suggested that inhibition of DVL2 can sensitize cisplatin-resistant lung cancer cells through down-regulating Wnt/beta-catenin signaling and inhibiting BCRP, MRP4, and Survivin expression.	Cisplatin	78-87	dishevelled segment polarity protein 2	Homo sapiens	59-63
23396967-4	2013	In the present study, we mapped the 10B5 epitope to a 16-amino acid segment of human Dvl2 (residues 594-609) that contains four Ser/Thr residues.	Serine	128-131	dishevelled segment polarity protein 2	Homo sapiens	85-89
27086035-6	2016	Treatment of CLL cells with anti-ROR1 specific monoclonal antibodies induced dephosphorylation of ROR1 as well as of tyrosine and serine residues of both DVL2 and DVL3.	Tyrosine	117-125	dishevelled segment polarity protein 2	Homo sapiens	154-158
27086035-6	2016	Treatment of CLL cells with anti-ROR1 specific monoclonal antibodies induced dephosphorylation of ROR1 as well as of tyrosine and serine residues of both DVL2 and DVL3.	Serine	130-136	dishevelled segment polarity protein 2	Homo sapiens	154-158
24606934-0	2014	Biophysical and molecular-dynamics studies of phosphatidic acid binding by the Dvl-2 DEP domain.	Phosphatidic Acids	46-63	dishevelled segment polarity protein 2	Homo sapiens	79-84
24606934-4	2014	In this report, we elucidate the structural and functional basis of PA association to the Dvl2 DEP domain.	Phosphatidic Acids	68-70	dishevelled segment polarity protein 2	Homo sapiens	90-94
24606934-7	2014	We also show that the Dvl2 DEP domain bound PA in a pH-dependent manner in a mechanism that resembles deprotonation of PA.	Phosphatidic Acids	44-46	dishevelled segment polarity protein 2	Homo sapiens	22-26
24606934-7	2014	We also show that the Dvl2 DEP domain bound PA in a pH-dependent manner in a mechanism that resembles deprotonation of PA.	Phosphatidic Acids	119-121	dishevelled segment polarity protein 2	Homo sapiens	22-26
24606934-8	2014	Collectively, our results structurally define the PA-binding properties of the Dvl2 DEP domain, which can be exploited for the investigation of binding mechanisms of other DEP domain-interacting proteins.	Phosphatidic Acids	50-52	dishevelled segment polarity protein 2	Homo sapiens	79-83
24064724-4	2013	Our results from molecular simulation of curcumin binding to Dvl2 protein and from binding free energy calculations suggest that curcumin may prevent axin recruitment to cellular membrane in order to maintain the functional beta-catenin destruction complex in normal cells.	Curcumin	41-49	dishevelled segment polarity protein 2	Homo sapiens	61-65
24064724-4	2013	Our results from molecular simulation of curcumin binding to Dvl2 protein and from binding free energy calculations suggest that curcumin may prevent axin recruitment to cellular membrane in order to maintain the functional beta-catenin destruction complex in normal cells.	Curcumin	129-137	dishevelled segment polarity protein 2	Homo sapiens	61-65
24505507-3	2013	In cell-based assays, whereas Sestd1 does not alter Dvl2 activation of the Wnt/beta-catenin signaling pathway, Dvl2 enhances activation of Rho family GTPases by Dact1 and Sestd1, consistent with a role in the PCP pathway.	pcp	209-212	dishevelled segment polarity protein 2	Homo sapiens	111-115
24505507-5	2013	This genetic synergy stands in contrast to the epistasis we have previously reported between Sestd1 and Dact1 KO, and suggests independent or semi-independent functions for Dvl2 vs. Sestd1/Dact1 in the regulation of the PCP pathway during development.	pcp	220-223	dishevelled segment polarity protein 2	Homo sapiens	173-177
24505507-6	2013	In conclusion, biochemical and genetic interactions between Dvl2, Sestd1, and Dact1, in addition to prior reported interactions between these same molecules and Vangl2, suggest that all these gene products can form complexes together and regulate the PCP pathway during mammalian development.	pcp	251-254	dishevelled segment polarity protein 2	Homo sapiens	60-64
25907794-4	2015	Here, we generate milligram quantities of pure human Dvl2 DIX domain mono-ubiquitinated at two lysines (K54 and K58) by genetically encoded orthogonal protection with activated ligation (GOPAL), to investigate their effect on DIX polymerization.	Lysine	95-102	dishevelled segment polarity protein 2	Homo sapiens	53-57
24616100-7	2014	Biochemical analyses revealed that IRS1/2 decreased Lys-63-linked ubiquitination of Dvl2 and stabilized Dvl2 protein via suppressing its autophagy-mediated degradation.	Lysine	52-55	dishevelled segment polarity protein 2	Homo sapiens	84-88
24427302-6	2014	The Wnt signaling-targeted genes, c-Myc, CCND1 and the proteins Dvl2/3, were all up-regulated in fibroblasts expressing high levels of IGFBP7, and the up-regulation could be inhibited both by the Wnt signaling antagonist Dickkopf-1 (DKK1) and by the TGF-beta1 receptor antagonist SB431542.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	280-288	dishevelled segment polarity protein 2	Homo sapiens	64-70
23396967-4	2013	In the present study, we mapped the 10B5 epitope to a 16-amino acid segment of human Dvl2 (residues 594-609) that contains four Ser/Thr residues.	Threonine	132-135	dishevelled segment polarity protein 2	Homo sapiens	85-89
23396967-11	2013	Thus, we have identified a cluster of Ser/Thr residues in the C-terminal domain of Dvl2 that are Wnt-induced phosphorylation (WIP) sites.	Serine	38-41	dishevelled segment polarity protein 2	Homo sapiens	83-87
23396967-11	2013	Thus, we have identified a cluster of Ser/Thr residues in the C-terminal domain of Dvl2 that are Wnt-induced phosphorylation (WIP) sites.	Threonine	42-45	dishevelled segment polarity protein 2	Homo sapiens	83-87
22150777-11	2012	When compared to controls, EtOH, at both 20 and 100 mM concentrations, suppressed the expression of Wnt3a and Wnt5a, receptor complex proteins p-LRP6, LRP6 and DVL2, and cytoplasmic proteins Ser-p-GSK3beta and beta-catenin.	Ethanol	27-31	dishevelled segment polarity protein 2	Homo sapiens	160-164