PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33027873-5	2020	Tralopyril decreased the thyroid hormone concentrations in embryos and changed the transcriptions of the related genes (TRHR, TSHbeta, TSHR, Nkx2.1, Dio1, TRalpha, TRbeta, TTR and UGT1ab).	4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile	0-10	iodothyronine deiodinase 1	Danio rerio	149-153
33396108-7	2021	The levels of THs were regulated by the negative feedback loops through HPT axis related genes, most of which (NIS, Deio1, Deio2, TRalpha, TSHbeta and UGT1ab) were significantly depressed after exposure to uranium.	Uranium	206-213	iodothyronine deiodinase 1	Danio rerio	116-121
33182161-5	2021	Following a 5 d exposure to PFTrDA, zebrafish larvae showed upregulation of the genes responsible for thyroid hormone synthesis (tshbeta, nkx2.1, nis, tpo, mct8) and (de)activation (dio1, dio2).	pftrda	28-34	iodothyronine deiodinase 1	Danio rerio	182-186
32871520-9	2020	Likewise, genes encoding thyronine deiodinases (dio1, dio2, and dio3a/b) and thyroid hormone receptors (tralpha and trbeta) also had their transcription downregulated in zebrafish.	Thyronines	25-34	iodothyronine deiodinase 1	Danio rerio	48-52
35131581-9	2022	Significant increases in corticotrophin-releasing hormone (crh) and transthyretin (ttr) gene expression were also observed when the zebrafish larvae were treated with 12 mg/L PFHxA, except iodothyronine deiodinases (dio1), which decreased obviously at that point.	perfluorohexanoic acid	175-180	iodothyronine deiodinase 1	Danio rerio	216-220
32623180-11	2020	T3 exposure suppressed the transcript levels of dio1 and dio2 in the liver, brain, gastrointestinal tract and craniofacial tissues, while dio2 signalling was also suppressed in the pituitary gland.	Triiodothyronine	0-2	iodothyronine deiodinase 1	Danio rerio	48-52
32173372-3	2020	The results showed that whole-body total T4 and T3 levels were significantly decreased, which was accompanied by the significant upregulation of the expression of the dio1, dio2 and ugt1ab genes after exposure to TPT for 7 and 14 days.	triphenyltin	213-216	iodothyronine deiodinase 1	Danio rerio	167-171
30763833-5	2019	TBBPA exposure resulted in higher levels of mRNAs for genes encoding deiodinases (dio1), transport proteins (ttr), the thyroid follicle synthesis protein paired box 8 (pax8) and glucuronidation enzymes (ugt1ab) and lower levels of dio3b mRNAs in whole body extracts, with responses varying with developmental stage.	tetrabromobisphenol A	0-5	iodothyronine deiodinase 1	Danio rerio	82-86
30114598-6	2018	Transcription levels of TRH, TSHR, TPO, Dio1, TRalpha, and UGT1ab were significantly altered after flutolanil exposure.	flutolanil	99-109	iodothyronine deiodinase 1	Danio rerio	40-44
26397822-6	2016	The downregulation of genes related to thyroid hormone metabolism (dio1 and ugt1ab) and transport (ttr) in zebrafish larvae exposed to acetochlor might further explain the increased thyroxine levels and decreased T3 levels.	Thyroxine	182-191	iodothyronine deiodinase 1	Danio rerio	67-71
26055223-6	2015	In addition, the alteration of mRNA expression of VTG, ERalpha, ERbeta1, ERbeta2, TRalpha, TRbeta, Dio1, and Dio2 indicated the potential of carbendazim to induce endocrine disruption in zebrafish larvae.	carbendazim	141-152	iodothyronine deiodinase 1	Danio rerio	99-103
24123209-4	2014	In both sexes, PCP exposure resulted in decreased messenger RNA (mRNA) expression levels of thyroid-stimulating hormone beta-subunit (tshbeta) and thyroid hormone receptor beta (trbeta) in the brain, as well as increased liver levels of uridine diphosphoglucuronosyl transferase (ugt1ab) and decreased deiodinase 1 (dio1).	Pentachlorophenol	15-18	iodothyronine deiodinase 1	Danio rerio	316-320
19703701-8	2009	A significant increase in NIS and Dio1 gene expression was observed at 200 microg L(-1) PFOS exposure, while TG gene expression was down-regulated at 200 and 400 microg L(-1) PFOS exposure.	perfluorooctane sulfonic acid	88-92	iodothyronine deiodinase 1	Danio rerio	34-38