PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34742705-3	2022	Using PXE patient and control fibroblasts, (lesional) skin tissue and abcc6a-/- zebrafish, we performed expression analysis of DDR/PARP1 targets with QRT-PCR, western blot, immunohistochemistry and enzyme activity assays; before and after treatment with the PARP1 inhibitor minocycline.	Minocycline	274-285	poly (ADP-ribose) polymerase 1	Danio rerio	258-263
34742705-7	2022	Minocycline treatment attenuated DDR/PARP1 overexpression and reduced aberrant mineralization in PXE fibroblasts and abcc6a-/- zebrafish.	Minocycline	0-11	poly (ADP-ribose) polymerase 1	Danio rerio	37-42
35163765-2	2022	Recently, increased activation of the DNA damage response (DDR) was shown to be involved in PXE pathogenesis, while the DDR/PARP1 inhibitor minocycline was found to attenuate aberrant mineralization in PXE cells and zebrafish.	Minocycline	140-151	poly (ADP-ribose) polymerase 1	Danio rerio	124-129
25114913-4	2014	The notable deregulated proteins for PAHs exposure were displayed as follows: lamin-A/C isoform 3 and annexin A1 for benzopyrene; lamin-A/C isoform 3 and DNA topoisomerase 2-alpha for pentacene; poly[ADP-ribose] polymerase 1 (PARP-1) for fluoranthene; and talin-1 and DNA topoisomerase 2-alpha for pyrene.	fluoranthene	238-250	poly (ADP-ribose) polymerase 1	Danio rerio	195-224
21264220-1	2011	BACKGROUND: The PARP family member poly(ADP-ribose) polymerase 3 (PARP3) is structurally related to the well characterized PARP1 that orchestrates cellular responses to DNA strand breaks and cell death by the synthesis of poly(ADP-ribose).	Poly Adenosine Diphosphate Ribose	35-50	poly (ADP-ribose) polymerase 1	Danio rerio	123-128