PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32928908-8	2020	So far, SPY is best characterized for its role in gibberellin signaling via fucosylation of the growth-repressing DELLA protein REPRESSOR OF ga1-3 (RGA).	Gibberellins	50-61	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	8-11
8400871-1	1993	Three independent recessive mutations at the SPINDLY (SPY) locus of Arabidopsis confer resistance to the gibberellin (GA) biosynthesis inhibitor paclobutrazol.	paclobutrazol	145-158	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	45-52
8400871-1	1993	Three independent recessive mutations at the SPINDLY (SPY) locus of Arabidopsis confer resistance to the gibberellin (GA) biosynthesis inhibitor paclobutrazol.	paclobutrazol	145-158	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	54-57
8400871-4	1993	The spy-1 allele is partially epistatic to the ga1-2 mutation, which causes GA deficiency.	Gallium	76-78	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	4-7
8400871-5	1993	In addition, the spy-1 mutation can simultaneously suppress the effects of the ga1-2 mutation and paclobutrazol treatment, which inhibit different steps in the GA biosynthesis pathway.	paclobutrazol	98-111	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	17-20
8400871-5	1993	In addition, the spy-1 mutation can simultaneously suppress the effects of the ga1-2 mutation and paclobutrazol treatment, which inhibit different steps in the GA biosynthesis pathway.	Gallium	160-162	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	17-20
8400871-6	1993	This observation suggests that spy-1 activates a basal level of GA signal transduction that is independent of GA.	Gallium	64-66	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	31-34
34712252-0	2021	O-fucosylation of CPN20 by SPINDLY Derepresses Abscisic Acid Signaling During Seed Germination and Seedling Development.	Abscisic Acid	47-60	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	27-34
34712252-3	2021	In this study, we show that SPINDLY (SPY) interacts with CPN20 in yeast two-hybrid and split-luc assays, and the interaction is promoted by ABA.	Abscisic Acid	140-143	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	28-35
34712252-3	2021	In this study, we show that SPINDLY (SPY) interacts with CPN20 in yeast two-hybrid and split-luc assays, and the interaction is promoted by ABA.	Abscisic Acid	140-143	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	37-40
34712252-9	2021	Genetic analysis shows that ABA insensitive phenotypes of spy-3 in terms of seed germination and early seedling development are partially suppressed by the cpn20 mutation, suggesting that CPN20 acts downstream of SPY in this ABA signaling pathway and that there may exist other pathways in parallel with CPN20.	Abscisic Acid	225-228	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	213-216
34712252-10	2021	Collectively, the above data support the notion that the O-fucosylation of CPN20 by SPY fine-tunes ABA signaling in Arabidopsis.	Abscisic Acid	99-102	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	84-87
33476897-3	2021	The paralog of AtSPY, SECRET AGENT (SEC), is an O-link-N-acetylglucosamine (GlcNAc) transferase (OGT), which O-GlcNAcylates Ser/Thr residues of target proteins.	Serine	124-127	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	15-20
33476897-3	2021	The paralog of AtSPY, SECRET AGENT (SEC), is an O-link-N-acetylglucosamine (GlcNAc) transferase (OGT), which O-GlcNAcylates Ser/Thr residues of target proteins.	Threonine	128-131	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	15-20
27208284-4	2016	Here, we aimed to identify how SPY regulates TCP14/15 activities and how these TCPs promote CK responses.	Cytokinins	92-94	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	31-34
31899321-3	2020	O-fucosyltransferase SPINDLY (SPY), and O-GlcNAc transferase SECRET AGENT (SEC) are two prominent O-glycosylation enzymes in higher plants, with both overlapped and unique functions in plant growth and development.	2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose	40-48	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	30-33
31899321-6	2020	PRR5 can be O-fucosylated by SPY in planta, while point mutations in the SPY catalytic domain abolishes the O-fucosylation of PRR5.	fucosylated chondroitin sulfate	12-25	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	29-32
31899321-6	2020	PRR5 can be O-fucosylated by SPY in planta, while point mutations in the SPY catalytic domain abolishes the O-fucosylation of PRR5.	fucosylated chondroitin sulfate	12-25	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	73-76
27208284-0	2016	The Putative O-Linked N-Acetylglucosamine Transferase SPINDLY Inhibits Class I TCP Proteolysis to Promote Sensitivity to Cytokinin.	N-(3,4,5-trichlorophenyl)succinimide	79-82	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	54-61
22013217-0	2011	SPINDLY, a negative regulator of gibberellic acid signaling, is involved in the plant abiotic stress response.	gibberellic acid	33-49	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	0-7
27208284-1	2016	Arabidopsis (Arabidopsis thaliana) SPINDLY (SPY) is a putative serine and threonine O-linked N-acetylglucosamine transferase (OGT).	Serine	63-69	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	35-42
27208284-1	2016	Arabidopsis (Arabidopsis thaliana) SPINDLY (SPY) is a putative serine and threonine O-linked N-acetylglucosamine transferase (OGT).	Serine	63-69	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	44-47
27208284-1	2016	Arabidopsis (Arabidopsis thaliana) SPINDLY (SPY) is a putative serine and threonine O-linked N-acetylglucosamine transferase (OGT).	Threonine	74-83	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	35-42
27208284-1	2016	Arabidopsis (Arabidopsis thaliana) SPINDLY (SPY) is a putative serine and threonine O-linked N-acetylglucosamine transferase (OGT).	Threonine	74-83	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	44-47
27208284-3	2016	We previously showed that SPY interacts physically and functionally with TCP14 and TCP15 to promote CK responses.	Cytokinins	100-102	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	26-29
23893173-9	2013	Furthermore, we show that SWI3C also interacts with the O-GlcNAc (O-linked N-acetylglucosamine) transferase SPINDLY required for proper functioning of DELLAs and acts hypostatically to (SPINDLY) in the GA response pathway.	o-glcnac	56-64	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	108-115
23893173-9	2013	Furthermore, we show that SWI3C also interacts with the O-GlcNAc (O-linked N-acetylglucosamine) transferase SPINDLY required for proper functioning of DELLAs and acts hypostatically to (SPINDLY) in the GA response pathway.	o-glcnac	56-64	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	186-193
25267734-7	2014	We therefore have not only gained insight into the mechanism by which SPY regulates root development but also uncovered a novel pathway for ROS signaling in plants.	Reactive Oxygen Species	140-143	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	70-73
22267487-0	2012	The Arabidopsis O-linked N-acetylglucosamine transferase SPINDLY interacts with class I TCPs to facilitate cytokinin responses in leaves and flowers.	N-(3,4,5-trichlorophenyl)succinimide	88-92	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	57-64
22267487-3	2012	Here, we present evidence that two closely related class I TCP transcription factors, TCP14 and TCP15, act with SPY to promote CK responses.	Cytokinins	127-129	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	112-115
22013217-1	2011	The SPINDLY (SPY) gene was first identified as a negative regulator of plant gibberellic acid (GA) signaling because mutation of this gene phenocopies plants treated with an overdose of bioactive GA and results in insensitivity to a GA inhibitor during seed germination.	gibberellic acid	77-93	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	4-11
22013217-1	2011	The SPINDLY (SPY) gene was first identified as a negative regulator of plant gibberellic acid (GA) signaling because mutation of this gene phenocopies plants treated with an overdose of bioactive GA and results in insensitivity to a GA inhibitor during seed germination.	gibberellic acid	77-93	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	13-16
22013217-1	2011	The SPINDLY (SPY) gene was first identified as a negative regulator of plant gibberellic acid (GA) signaling because mutation of this gene phenocopies plants treated with an overdose of bioactive GA and results in insensitivity to a GA inhibitor during seed germination.	gibberellic acid	95-97	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	4-11
22013217-1	2011	The SPINDLY (SPY) gene was first identified as a negative regulator of plant gibberellic acid (GA) signaling because mutation of this gene phenocopies plants treated with an overdose of bioactive GA and results in insensitivity to a GA inhibitor during seed germination.	gibberellic acid	95-97	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	13-16
22013217-3	2011	In this study, we describe the strong salt and drought tolerance phenotypes of Arabidopsis (Arabidopsis thaliana) spy-1 and spy-3 mutants in addition to their GA-related phenotypes.	Salts	38-42	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	114-117
22013217-3	2011	In this study, we describe the strong salt and drought tolerance phenotypes of Arabidopsis (Arabidopsis thaliana) spy-1 and spy-3 mutants in addition to their GA-related phenotypes.	Salts	38-42	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	124-127
22013217-3	2011	In this study, we describe the strong salt and drought tolerance phenotypes of Arabidopsis (Arabidopsis thaliana) spy-1 and spy-3 mutants in addition to their GA-related phenotypes.	gibberellic acid	159-161	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	124-127
22013217-4	2011	SPY gene expression was found to be drought stress inducible and slightly responsive to salt stress.	Salts	88-92	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	0-3
22013217-5	2011	Transcriptome analysis of spy-3 revealed that many GA-responsive genes were up-regulated, which could explain the GA-overdosed phenotype of spy-3.	gibberellic acid	51-53	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	26-29
22013217-5	2011	Transcriptome analysis of spy-3 revealed that many GA-responsive genes were up-regulated, which could explain the GA-overdosed phenotype of spy-3.	gibberellic acid	51-53	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	140-143
22013217-5	2011	Transcriptome analysis of spy-3 revealed that many GA-responsive genes were up-regulated, which could explain the GA-overdosed phenotype of spy-3.	gibberellic acid	114-116	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	26-29
22013217-5	2011	Transcriptome analysis of spy-3 revealed that many GA-responsive genes were up-regulated, which could explain the GA-overdosed phenotype of spy-3.	gibberellic acid	114-116	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	140-143
20404857-6	2010	The transcription levels of genes involved in trichome initiation were found to be strongly affected, including GLABRA1, TRANSPARENT TESTA GLABROUS 1, TRIPTYCHON and SPINDLY, expression of which is regulated by gibberellic acids (GAs).	gibberellic acid	211-228	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	166-173
19228341-5	2009	Using chimeric GFP-SPY fused to a nuclear-export signal or to a glucocorticoid receptor, we show that cytosolic SPY promotes cytokinin responses and suppresses GA signaling.	Gallium	160-162	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	112-115
16014901-7	2005	By matrix-assisted laser desorption ionization-time of flight mass spectrometry, we determined that a 39-residue tryptic peptide from the N terminus of CP of PPV purified from the spy-3 mutant, but not sec-1 or sec-2, was O-GlcNAc modified, suggesting that SEC but not SPY modifies the capsid.	Peptides	121-128	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	180-183
18162586-7	2008	Interestingly, ABA-deficient aba2-2 mutant seeds show significant expression of GA synthesis genes and repression of SPY expression even at high temperature.	Abscisic Acid	15-18	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	117-120
17052323-0	2006	The rice SPINDLY gene functions as a negative regulator of gibberellin signaling by controlling the suppressive function of the DELLA protein, SLR1, and modulating brassinosteroid synthesis.	Brassinosteroids	164-179	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	9-16
19228341-2	2009	Coordination of the two pathways involves the O-linked N-acetylglucosamine transferase SPINDLY (SPY) that suppresses GA signaling and promotes cytokinin responses in Arabidopsis.	Gallium	117-119	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	87-94
19228341-2	2009	Coordination of the two pathways involves the O-linked N-acetylglucosamine transferase SPINDLY (SPY) that suppresses GA signaling and promotes cytokinin responses in Arabidopsis.	Gallium	117-119	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	96-99
17142481-12	2007	We propose that SPY may function as a negative regulator of GA response by increasing the activity of RGA, and presumably other DELLA proteins, by GlcNAc modification.	2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose	147-153	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	16-19
16679458-6	2006	Genetic and gene expression analyses suggest that GIS acts in a GA-responsive pathway upstream of the trichome initiation regulator GLABROUS1 (GL1) and downstream of the GA signaling repressor SPINDLY (SPY).	Gallium	64-66	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	202-205
16916886-2	2006	This study demonstrates that the ABA Insensitive 3 (ABI3) gene in the ABA signalling pathway and the RGA-like 2 (RGL2) and SPINDLY (SPY) genes in the GA signalling pathways all play important roles in the glucose-induced delay of seed germination.	alisol B 23-acetate	33-36	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	123-130
16916886-2	2006	This study demonstrates that the ABA Insensitive 3 (ABI3) gene in the ABA signalling pathway and the RGA-like 2 (RGL2) and SPINDLY (SPY) genes in the GA signalling pathways all play important roles in the glucose-induced delay of seed germination.	alisol B 23-acetate	33-36	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	132-135
16916886-2	2006	This study demonstrates that the ABA Insensitive 3 (ABI3) gene in the ABA signalling pathway and the RGA-like 2 (RGL2) and SPINDLY (SPY) genes in the GA signalling pathways all play important roles in the glucose-induced delay of seed germination.	Glucose	205-212	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	123-130
16916886-2	2006	This study demonstrates that the ABA Insensitive 3 (ABI3) gene in the ABA signalling pathway and the RGA-like 2 (RGL2) and SPINDLY (SPY) genes in the GA signalling pathways all play important roles in the glucose-induced delay of seed germination.	Glucose	205-212	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	132-135
16916886-6	2006	Comparison of WT and spy seedling growth on different glucose concentrations suggests that the stimulatory effect of glucose is partially exerted via the GA or cytokinin signalling pathways.	Glucose	54-61	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	21-24
16916886-6	2006	Comparison of WT and spy seedling growth on different glucose concentrations suggests that the stimulatory effect of glucose is partially exerted via the GA or cytokinin signalling pathways.	Glucose	117-124	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	21-24
16014901-7	2005	By matrix-assisted laser desorption ionization-time of flight mass spectrometry, we determined that a 39-residue tryptic peptide from the N terminus of CP of PPV purified from the spy-3 mutant, but not sec-1 or sec-2, was O-GlcNAc modified, suggesting that SEC but not SPY modifies the capsid.	Peptides	121-128	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	269-272
11457967-4	2001	To test the hypothesis that SPY acts specifically as a negatively acting component of GA signal transduction, spy mutants and plants containing a 35S:SPY construct have been examined.	Gallium	86-88	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	28-31
15608330-1	2005	SPINDLY (SPY) is a negative regulator of gibberellin (GA) responses; however, spy mutants exhibit various phenotypic alterations not found in GA-treated plants.	Gallium	54-56	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	0-7
15608330-1	2005	SPINDLY (SPY) is a negative regulator of gibberellin (GA) responses; however, spy mutants exhibit various phenotypic alterations not found in GA-treated plants.	Gallium	54-56	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	9-12
15608330-1	2005	SPINDLY (SPY) is a negative regulator of gibberellin (GA) responses; however, spy mutants exhibit various phenotypic alterations not found in GA-treated plants.	Gallium	54-56	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	78-81
15608330-3	2005	GA also repressed the effects of cytokinin, suggesting that there is cross talk between the two hormone-response pathways, which may involve SPY function.	Gallium	0-2	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	141-144
15608330-8	2005	Our results demonstrate that SPY acts as both a repressor of GA responses and a positive regulator of cytokinin signaling.	Gallium	61-63	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	29-32
15347799-2	2004	Many, if not all, GA-dependent responses require SPY protein, and to improve our understanding of how the SPY signaling pathway operates, a yeast two-hybrid screen was used to identify both upstream and downstream components that might regulate the activity of the HvSPY protein.	Gallium	18-20	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	49-52
12068105-0	2002	SPINDLY is a nuclear-localized repressor of gibberellin signal transduction expressed throughout the plant.	Gibberellins	44-55	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	0-7
12068105-7	2002	This result is consistent with the nuclear localization of other components of the GA response pathway and suggests that SPY"s role as a negative regulator of GA signaling involves interaction with other nuclear proteins and/or O-N-acetyl-glucosamine modification of these proteins.	Gallium	83-85	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	121-124
12068105-7	2002	This result is consistent with the nuclear localization of other components of the GA response pathway and suggests that SPY"s role as a negative regulator of GA signaling involves interaction with other nuclear proteins and/or O-N-acetyl-glucosamine modification of these proteins.	o-n-acetyl-glucosamine	228-250	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	121-124
11457975-0	2001	Ectopic expression of the tetratricopeptide repeat domain of SPINDLY causes defects in gibberellin response.	Gibberellins	87-98	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	61-68
11457975-8	2001	Expression of the TPR domain in a wild-type background produces phenotypes similar to those caused by loss-of-function spy mutants including resistance to GA biosynthesis inhibitors, short hypocotyl length, and early flowering.	Gallium	155-157	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	119-122
8799194-4	1996	Recessive mutations at the SPINDLY (SPY) locus cause a phenotype that is consistent with constitutive activation of GA signal transduction.	Gallium	116-118	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	27-34
8799194-4	1996	Recessive mutations at the SPINDLY (SPY) locus cause a phenotype that is consistent with constitutive activation of GA signal transduction.	Gallium	116-118	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	36-39