PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
31792371-0	2020	PACSIN2 rs2413739 influence on thiopurine pharmacokinetics: validation studies in pediatric patients.	2-mercaptopyrazine	31-41	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	0-7
34720526-5	2021	In this editorial, we discuss evidence supporting the use of PACSIN2, RAC1, and ITPA genes, in addition to TPMT and NUDT15, as possible biomarkers for thiopurine-related gastrointestinal toxicity.	2-mercaptopyrazine	151-161	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	61-68
32966336-7	2020	Moreover, we demonstrate that at least 3 different asparagine-proline-phenylalanine (NPF) motif-containing EHD binding partners, Rabenosyn-5, Syndapin2 and MICAL-L1, are required for the recruitment of EHD1 to SE.	npf	85-88	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	142-151
11352907-5	2001	PACSIN 2 shows enhanced binding to the mSos proline-rich domain in pull-down assays from brain extracts as compared with lung extracts, suggesting a tissue-specific regulation of the interaction.	Proline	44-51	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	0-8
32878944-0	2020	Regulation of caveolae through cholesterol-depletion dependent tubulation by PACSIN2/Syndapin II.	Cholesterol	31-42	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	77-84
32878944-0	2020	Regulation of caveolae through cholesterol-depletion dependent tubulation by PACSIN2/Syndapin II.	Cholesterol	31-42	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	85-96
32878944-4	2020	We show that the binding of PACSIN2 to the membrane could be negatively regulated by cholesterol.	Cholesterol	85-96	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	28-35
32878944-6	2020	The reconstituted membrane with cholesterol had a weaker affinity to the F-BAR domain of PACSIN2 than the membrane without cholesterol.	Cholesterol	32-43	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	89-96
32878944-6	2020	The reconstituted membrane with cholesterol had a weaker affinity to the F-BAR domain of PACSIN2 than the membrane without cholesterol.	Cholesterol	123-134	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	89-96
32878944-7	2020	Consistently, the depletion of cholesterol from the plasma membrane induced the PACSIN2-localized tubules with caveolin-1 at their tips, suggesting that cholesterol inhibited the membrane tubulation by PACSIN2.	Cholesterol	31-42	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	80-87
32878944-7	2020	Consistently, the depletion of cholesterol from the plasma membrane induced the PACSIN2-localized tubules with caveolin-1 at their tips, suggesting that cholesterol inhibited the membrane tubulation by PACSIN2.	Cholesterol	31-42	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	202-209
32878944-7	2020	Consistently, the depletion of cholesterol from the plasma membrane induced the PACSIN2-localized tubules with caveolin-1 at their tips, suggesting that cholesterol inhibited the membrane tubulation by PACSIN2.	Cholesterol	153-164	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	80-87
32878944-7	2020	Consistently, the depletion of cholesterol from the plasma membrane induced the PACSIN2-localized tubules with caveolin-1 at their tips, suggesting that cholesterol inhibited the membrane tubulation by PACSIN2.	Cholesterol	153-164	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	202-209
32878944-9	2020	Consistently, the removal of caveolae from the plasma membrane upon cholesterol depletion was diminished in the PACSIN2-deficient cells.	Cholesterol	68-79	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	112-119
32878944-10	2020	These data suggested that PACSIN2 mediated caveolae internalization dependently on the amount of cholesterol, providing a mechanism for cholesterol-dependent regulation of caveolae.	Cholesterol	97-108	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	26-33
32878944-10	2020	These data suggested that PACSIN2 mediated caveolae internalization dependently on the amount of cholesterol, providing a mechanism for cholesterol-dependent regulation of caveolae.	Cholesterol	136-147	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	26-33
31792371-1	2020	The aim of the study was to validate the impact of the single-nucleotide polymorphism rs2413739 (T > C) in the PACSIN2 gene on thiopurines pharmacological parameters and clinical response in an Italian cohort of pediatric patients with acute lymphoblastic leukemia (ALL) and inflammatory bowel disease (IBD).	thiopurines	127-138	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	111-118
31792371-6	2020	These results support the role of PACSIN2 polymorphism on TPMT activity and mercaptopurine adverse effects in patients with ALL.	Mercaptopurine	76-90	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	34-41
31792371-7	2020	Further evidence on PBMC and pediatric patients with IBD supports an association between PACSIN2 variants, TPMT activity, and thiopurines effects, even if more studies are needed since some of these effects may be tissue specific.	thiopurines	126-137	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	89-96
25248744-7	2014	Given that MICAL-L1 and the F-BAR-containing membrane-tubulating protein Syndapin2 associate selectively with phosphatidic acid, we propose a positive feedback loop in which DGKalpha generates phosphatidic acid to drive its own recruitment to TRE via its interaction with MICAL-L1.	Phosphatidic Acids	110-127	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	73-82
27452984-0	2016	PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy.	2-mercaptopyrazine	40-50	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	0-7
26092940-2	2015	Here, we found that protein kinase C (PKC) phosphorylates PACSIN2 at serine 313, thereby decreasing its membrane binding and tubulation capacities.	Serine	69-75	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	58-65
26092940-5	2015	Both hypotonic treatment and isotonic drug-induced PKC activation increased PACSIN2 phosphorylation at serine 313 and shortened caveolar-tracking durations.	Serine	103-109	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	76-83
31801866-8	2020	Interestingly, NS5A specifically attenuated protein kinase C alpha (PKCalpha)-mediated phosphorylation of PACSIN2 at serine 313 by interrupting PACSIN2 and PKCalpha interaction.	Serine	117-123	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	106-113
31801866-16	2020	Taken together, these data indicate that HCV modulates PACSIN2 via NS5A to promote virion assembly.IMPORTANCE PACSIN2 is a lipid-binding protein that triggers the tubulation of the phosphatidic acid-containing membranes.	Phosphatidic Acids	181-198	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	55-62
31801866-16	2020	Taken together, these data indicate that HCV modulates PACSIN2 via NS5A to promote virion assembly.IMPORTANCE PACSIN2 is a lipid-binding protein that triggers the tubulation of the phosphatidic acid-containing membranes.	Phosphatidic Acids	181-198	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	110-117
31801866-21	2020	We showed that HCV NS5A interrupted PKCalpha-mediated PACSIN2 phosphorylation at serine 313, thereby promoting NS5A-PACSIN2 interaction.	Serine	81-87	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	54-61
31801866-21	2020	We showed that HCV NS5A interrupted PKCalpha-mediated PACSIN2 phosphorylation at serine 313, thereby promoting NS5A-PACSIN2 interaction.	Serine	81-87	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	116-123
27189942-5	2016	Also crucial for TRE biogenesis is the generation of phosphatidic acid, an essential lipid component of TRE that serves as a docking point for MICAL-L1 and Syndapin2.	Phosphatidic Acids	53-70	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	156-165
25248744-7	2014	Given that MICAL-L1 and the F-BAR-containing membrane-tubulating protein Syndapin2 associate selectively with phosphatidic acid, we propose a positive feedback loop in which DGKalpha generates phosphatidic acid to drive its own recruitment to TRE via its interaction with MICAL-L1.	Phosphatidic Acids	193-210	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	73-82
22846425-0	2012	PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity.	Mercaptopurine	50-64	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	0-7
23335936-4	2012	The use of high-throughput genomic analysis allows identification of additional candidate genetic factors associated with pharmacogenetic phenotypes, such as TPMT enzymatic activity: PACSIN2 polymorphisms have been identified by a genome-wide analysis, combining evaluation of polymorphisms and gene expression, as a significant determinant of TPMT activity in the HapMap CEU cell lines and the effects of PACSIN2 on TPMT activity and mercaptopurine induced adverse effects were confirmed in children with ALL.	Mercaptopurine	435-449	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	183-190
23596323-7	2013	We demonstrate that MICAL-L1 and the BAR-domain protein syndapin2 bind to phosphatidic acid, which we identify as a novel lipid component of RE.	Phosphatidic Acids	74-91	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	56-65
23596323-9	2013	Indeed, the presence of phosphatidic acid in liposomes enhances the ability of syndapin2 to tubulate membranes in vitro.	Phosphatidic Acids	24-41	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	79-88
22846425-7	2012	Moreover, this PACSIN2 SNP was significantly associated with the incidence of severe gastrointestinal (GI) toxicity during consolidation therapy containing mercaptopurine, and remained significant in a multivariate analysis including TPMT and SLCO1B1 as covariates, consistent with its influence on TPMT activity.	Mercaptopurine	156-170	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	15-22
22846425-9	2012	These data indicate that polymorphism in PACSIN2 significantly modulates TPMT activity and influences the risk of GI toxicity associated with mercaptopurine therapy.	Mercaptopurine	142-156	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	41-48
20188097-0	2010	Mapping of the basic amino-acid residues responsible for tubulation and cellular protrusion by the EFC/F-BAR domain of pacsin2/Syndapin II.	Amino Acids, Basic	15-31	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	119-126
20188097-0	2010	Mapping of the basic amino-acid residues responsible for tubulation and cellular protrusion by the EFC/F-BAR domain of pacsin2/Syndapin II.	Amino Acids, Basic	15-31	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	127-138
20188097-4	2010	The hydrophobic loops and the basic amino-acid residues on the concave surface of the pacsin2 EFC/F-BAR domain are essential for both the microspike formation and tubulation.	Amino Acids, Basic	30-46	protein kinase C and casein kinase substrate in neurons 2	Homo sapiens	86-93