PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34133054-6	2021	Additionally, we find an FMRP target, the activity-regulated cytoskeleton-associated protein (Arc), to be significantly reduced in synaptic cellular fractions prepared from the nucleus accumbens of Fmr1 KO, compared to WT, mice following operant tasks reinforced with cocaine, but not food.	Cocaine	268-275	activity regulated cytoskeletal-associated protein	Mus musculus	42-92
34728342-4	2021	METHODS: Targeted recombination in active populations (TRAP) is a newly developed method for labeling active neurons by using tamoxifen-inducible Cre recombination controlled by the promoter of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1), a member of immediate early genes.	Tamoxifen	126-135	activity regulated cytoskeletal-associated protein	Mus musculus	213-256
34133054-6	2021	Additionally, we find an FMRP target, the activity-regulated cytoskeleton-associated protein (Arc), to be significantly reduced in synaptic cellular fractions prepared from the nucleus accumbens of Fmr1 KO, compared to WT, mice following operant tasks reinforced with cocaine, but not food.	Cocaine	268-275	activity regulated cytoskeletal-associated protein	Mus musculus	94-97
32170298-5	2020	PEE repressed the expression of several synaptic plasticity genes, such as brain-derived neurotrophic factor (Bdnf), C-Fos, early growth response 1 (Egr1) and activity-regulated cytoskeleton-associated protein (Arc).	pee	0-3	activity regulated cytoskeletal-associated protein	Mus musculus	159-209
34093130-0	2021	Dynamic Changes of Arc Expression in Dorsal Striatum of Mice After Self-Administration of Sucrose.	Sucrose	90-97	activity regulated cytoskeletal-associated protein	Mus musculus	19-22
34093130-3	2021	To address this issue, the activity-regulated cytoskeleton-associated protein (Arc) expressions in the subregional dorsal striatum were analyzed during the early and late learning phases of the 10-day sucrose self-administration process.	Sucrose	201-208	activity regulated cytoskeletal-associated protein	Mus musculus	27-77
34093130-3	2021	To address this issue, the activity-regulated cytoskeleton-associated protein (Arc) expressions in the subregional dorsal striatum were analyzed during the early and late learning phases of the 10-day sucrose self-administration process.	Sucrose	201-208	activity regulated cytoskeletal-associated protein	Mus musculus	79-82
33584180-9	2020	These results suggested region-specific changes of p-beta-actin, Arc/Arg3.1, and p-ERK1/2 protein during establishment and extinction phases of morphine-induced CPP.	Morphine	144-152	activity regulated cytoskeletal-associated protein	Mus musculus	65-75
32170298-5	2020	PEE repressed the expression of several synaptic plasticity genes, such as brain-derived neurotrophic factor (Bdnf), C-Fos, early growth response 1 (Egr1) and activity-regulated cytoskeleton-associated protein (Arc).	pee	0-3	activity regulated cytoskeletal-associated protein	Mus musculus	211-214
32170298-9	2020	TSA administration before PEE prevented PE-induced loss of Egr1 and Arc expression and neurobehavioral defects in adult mice via epigenetic remodeling.	trichostatin A	0-3	activity regulated cytoskeletal-associated protein	Mus musculus	68-71
31682894-0	2020	The activity-regulated cytoskeleton-associated protein, Arc/Arg3.1, influences mouse cocaine self-administration.	Cocaine	85-92	activity regulated cytoskeletal-associated protein	Mus musculus	4-66
31682894-1	2020	The activity-regulated cytoskeleton-associated protein (Arc, also known as Arg3.1), an immediate early gene and synaptic regulator, is upregulated following a single cocaine exposure.	Cocaine	166-173	activity regulated cytoskeletal-associated protein	Mus musculus	4-54
31682894-1	2020	The activity-regulated cytoskeleton-associated protein (Arc, also known as Arg3.1), an immediate early gene and synaptic regulator, is upregulated following a single cocaine exposure.	Cocaine	166-173	activity regulated cytoskeletal-associated protein	Mus musculus	56-59
31682894-1	2020	The activity-regulated cytoskeleton-associated protein (Arc, also known as Arg3.1), an immediate early gene and synaptic regulator, is upregulated following a single cocaine exposure.	Cocaine	166-173	activity regulated cytoskeletal-associated protein	Mus musculus	75-81
31682894-3	2020	Despite known learning and memory deficits in contextual fear and water-maze reversal learning tasks, we find that mice lacking Arc/Arg3.1 perform conditioned place preference and operant conditioning involving positive reinforcers (food and cocaine) with little-to-no impairment.	Cocaine	242-249	activity regulated cytoskeletal-associated protein	Mus musculus	128-138
31682894-4	2020	Specifically, Arc/Arg3.1 KO mice show a mild impairment early in the acquisition of cocaine intravenous self-administration (IVSA).	Cocaine	84-91	activity regulated cytoskeletal-associated protein	Mus musculus	14-17
31682894-4	2020	Specifically, Arc/Arg3.1 KO mice show a mild impairment early in the acquisition of cocaine intravenous self-administration (IVSA).	Cocaine	84-91	activity regulated cytoskeletal-associated protein	Mus musculus	18-24
31682894-6	2020	Importantly, Arc/Arg3.1 KO and WT mice behave comparably on an increasing cost task (FR1-FR3; acquisition dose), providing evidence that both groups find cocaine reinforcing.	Cocaine	154-161	activity regulated cytoskeletal-associated protein	Mus musculus	13-16
31682894-6	2020	Importantly, Arc/Arg3.1 KO and WT mice behave comparably on an increasing cost task (FR1-FR3; acquisition dose), providing evidence that both groups find cocaine reinforcing.	Cocaine	154-161	activity regulated cytoskeletal-associated protein	Mus musculus	17-23
29172439-2	2018	The influx of calcium through N-methyl-d-aspartate receptors (NMDARs) is a well-defined mechanism that leads to the increased expression of CREB-dependent genes, including brain derived neurotrophic factor (BDNF), microRNA-132, and activity-regulated cytoskeleton-associated protein (Arc).	Calcium	14-21	activity regulated cytoskeletal-associated protein	Mus musculus	232-282
30028018-5	2018	Moreover, VU0409551 treatment stabilized mGluR5 at the cellular plasma membrane of BACHD mice, increasing the expression of several genes important for synaptic plasticity, including c-Fos, brain-derived neurotrophic factor, Arc/Arg3.1, syntaxin 1A, and post-synaptic density-95.	VU0409551	10-19	activity regulated cytoskeletal-associated protein	Mus musculus	225-235
30143782-9	2019	Together, these findings propose that the postnatal ethanol-induced CB1R-mediated activation of CDK5 suppresses Arc and Rac1 expression in the mouse brain and is responsible for persistent synaptic plasticity and learning and memory defects in adult mice.	Ethanol	52-59	activity regulated cytoskeletal-associated protein	Mus musculus	112-115
30627149-7	2018	Additionally, we found increased neuronal activation evaluated by the identification of activity-regulated cytoskeleton-associated protein- (Arc-) labeled cells in the prefrontal cortex (PFC) in mice exposed to PAS during housing and in the absence or presence of PAS during FST.	Aminosalicylic Acid	211-214	activity regulated cytoskeletal-associated protein	Mus musculus	88-145
29172439-2	2018	The influx of calcium through N-methyl-d-aspartate receptors (NMDARs) is a well-defined mechanism that leads to the increased expression of CREB-dependent genes, including brain derived neurotrophic factor (BDNF), microRNA-132, and activity-regulated cytoskeleton-associated protein (Arc).	Calcium	14-21	activity regulated cytoskeletal-associated protein	Mus musculus	284-287
29932631-6	2018	Most notably, tianeptinaline, a class I HDAC-selective analogue of tianeptine, but not tianeptine itself, increased histone acetylation, and enhanced CREB-mediated transcription and the expression of Arc (activity-regulated cytoskeleton-associated protein).	Tianeptinaline	14-28	activity regulated cytoskeletal-associated protein	Mus musculus	200-255
27678087-4	2017	In rodent studies, vortioxetine increases glutamate neurotransmission, promotes dendritic branching and spine maturation, and elevates hippocampal expression of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) at the transcript level.	Vortioxetine	19-31	activity regulated cytoskeletal-associated protein	Mus musculus	217-227
29767695-5	2018	In humans, only 4 enzymes requiring molybdenum have been identified to date: sulfite oxidase, xanthine oxidase, aldehyde oxidase, and mitochondrial amidoxime-reducing component (mARC).	Molybdenum	36-46	activity regulated cytoskeletal-associated protein	Mus musculus	178-182
29767695-5	2018	In humans, only 4 enzymes requiring molybdenum have been identified to date: sulfite oxidase, xanthine oxidase, aldehyde oxidase, and mitochondrial amidoxime-reducing component (mARC).	amidoxime	148-157	activity regulated cytoskeletal-associated protein	Mus musculus	178-182
29767695-9	2018	Finally, mARC, discovered less than a decade ago, works in concert with cytochrome b5 type B and NAD(H) cytochrome b5 reductase to reduce a variety of N-hydroxylated substrates, although the physiologic significance is still unclear.	Nitrogen	97-98	activity regulated cytoskeletal-associated protein	Mus musculus	9-13
27567310-0	2017	Activity-Regulated Cytoskeleton-Associated Protein Accumulates in the Nucleus in Response to Cocaine and Acts as a Brake on Chromatin Remodeling and Long-Term Behavioral Alterations.	Cocaine	93-100	activity regulated cytoskeletal-associated protein	Mus musculus	0-50
27567310-7	2017	RESULTS: Arc messenger RNA and proteins are rapidly induced in the striatum after acute cocaine administration, via an extracellular-signal regulated kinase-dependent de novo protein synthesis.	Cocaine	88-95	activity regulated cytoskeletal-associated protein	Mus musculus	9-12
27567310-9	2017	In vitro, Arc overexpression downregulates phospho-Ser10-histone H3 without modifying extracellular-signal regulated kinase phosphorylation in the nucleus.	Dihydroxyacetone Phosphate	43-50	activity regulated cytoskeletal-associated protein	Mus musculus	10-13
27567310-9	2017	In vitro, Arc overexpression downregulates phospho-Ser10-histone H3 without modifying extracellular-signal regulated kinase phosphorylation in the nucleus.	ser10-histone	51-64	activity regulated cytoskeletal-associated protein	Mus musculus	10-13
27567310-12	2017	CONCLUSIONS: Cocaine induces the rapid induction of Arc and its nuclear accumulation in striatal neurons.	Cocaine	13-20	activity regulated cytoskeletal-associated protein	Mus musculus	52-55
27567310-14	2017	These original observations posit Arc as a major homeostatic modulator of molecular and behavioral responses to cocaine.	Cocaine	112-119	activity regulated cytoskeletal-associated protein	Mus musculus	34-37
29515368-8	2018	The inhibition of caspase-3 activity prior to ethanol administration prevented ethanol-induced loss of MeCP2, CREB activation, epigenetic regulation of Arc expression, long-term potentiation (LTP), spatial memory deficits and activity-dependent impairment of several signaling molecules, including MeCP2, in adult mice.	Ethanol	79-86	activity regulated cytoskeletal-associated protein	Mus musculus	152-155
27678087-6	2017	Chronic (1 month) vortioxetine increased Arc/Arg3.1 protein levels in the cortical synaptosomes of young and middle-aged mice.	Vortioxetine	18-30	activity regulated cytoskeletal-associated protein	Mus musculus	41-51
27678087-10	2017	In addition, chronic (1 month) vortioxetine, but not fluoxetine, restored the age-associated reduction in Arc/Arg3.1 and c-Fos transcripts in the frontal cortex of middle-aged mice.	Vortioxetine	31-43	activity regulated cytoskeletal-associated protein	Mus musculus	106-116
27614947-3	2016	We investigated the temporal expression of several IEGs, including c-fos, early growth response protein-1 (Egr-1), and activity-regulated cytoskeleton-associated protein (Arc), in trimethyltin (TMT)-induced hippocampal neurodegeneration.	trimethyltin	180-192	activity regulated cytoskeletal-associated protein	Mus musculus	119-169
27594097-2	2016	Our findings suggest that the 5-AzaC treatment significantly inhibited DNA methylation, impaired extracellular signal-regulated kinase (ERK1/2) activation and reduced expression of the activity-regulated cytoskeleton-associated protein (Arc).	Azacitidine	30-36	activity regulated cytoskeletal-associated protein	Mus musculus	185-235
27594097-2	2016	Our findings suggest that the 5-AzaC treatment significantly inhibited DNA methylation, impaired extracellular signal-regulated kinase (ERK1/2) activation and reduced expression of the activity-regulated cytoskeleton-associated protein (Arc).	Azacitidine	30-36	activity regulated cytoskeletal-associated protein	Mus musculus	237-240
27594097-5	2016	Together, these data demonstrate that the inhibition of DNA methylation by 5-AzaC treatment in P7 mice causes neurodegeneration and impairs ERK1/2 activation and Arc protein expression in neonatal mice and induces behavioral abnormalities in adult mice.	Azacitidine	75-81	activity regulated cytoskeletal-associated protein	Mus musculus	162-165
27614947-3	2016	We investigated the temporal expression of several IEGs, including c-fos, early growth response protein-1 (Egr-1), and activity-regulated cytoskeleton-associated protein (Arc), in trimethyltin (TMT)-induced hippocampal neurodegeneration.	trimethyltin	180-192	activity regulated cytoskeletal-associated protein	Mus musculus	171-174
27524619-0	2016	Genetic Disruption of Arc/Arg3.1 in Mice Causes Alterations in Dopamine and Neurobehavioral Phenotypes Related to Schizophrenia.	Dopamine	63-71	activity regulated cytoskeletal-associated protein	Mus musculus	26-32
24915645-0	2014	Chronic D-serine reverses arc expression and partially rescues dendritic abnormalities in a mouse model of NMDA receptor hypofunction.	D-serine	8-16	activity regulated cytoskeletal-associated protein	Mus musculus	26-29
25045021-0	2014	The mitochondrial amidoxime reducing component (mARC): involvement in metabolic reduction of N-oxides, oximes and N-hydroxyamidinohydrazones.	amidoxime	18-27	activity regulated cytoskeletal-associated protein	Mus musculus	48-52
25045021-0	2014	The mitochondrial amidoxime reducing component (mARC): involvement in metabolic reduction of N-oxides, oximes and N-hydroxyamidinohydrazones.	n-oxides	93-101	activity regulated cytoskeletal-associated protein	Mus musculus	48-52
25045021-0	2014	The mitochondrial amidoxime reducing component (mARC): involvement in metabolic reduction of N-oxides, oximes and N-hydroxyamidinohydrazones.	Oximes	103-109	activity regulated cytoskeletal-associated protein	Mus musculus	48-52
25045021-0	2014	The mitochondrial amidoxime reducing component (mARC): involvement in metabolic reduction of N-oxides, oximes and N-hydroxyamidinohydrazones.	n-hydroxyamidinohydrazones	114-140	activity regulated cytoskeletal-associated protein	Mus musculus	48-52
25045021-1	2014	The mitochondrial amidoxime reducing component (mARC) is a molybdenum-containing enzyme and capable of reducing N-hydroxylated structures such as amidoxime prodrugs.	amidoxime	18-27	activity regulated cytoskeletal-associated protein	Mus musculus	48-52
25045021-1	2014	The mitochondrial amidoxime reducing component (mARC) is a molybdenum-containing enzyme and capable of reducing N-hydroxylated structures such as amidoxime prodrugs.	Nitrogen	112-113	activity regulated cytoskeletal-associated protein	Mus musculus	48-52
25045021-1	2014	The mitochondrial amidoxime reducing component (mARC) is a molybdenum-containing enzyme and capable of reducing N-hydroxylated structures such as amidoxime prodrugs.	amidoxime	146-155	activity regulated cytoskeletal-associated protein	Mus musculus	48-52
25045021-2	2014	In this study, we tested the involvement of mARC in the reduction of N-oxides (amitriptyline-N-oxide, nicotinamide-N-oxide), oximes ((E)-/(Z)-2,4,6-trimethylacetophenonoxime) and a N-hydroxyamidinohydrazone (guanoxabenz).	n-oxides	69-77	activity regulated cytoskeletal-associated protein	Mus musculus	44-48
25045021-2	2014	In this study, we tested the involvement of mARC in the reduction of N-oxides (amitriptyline-N-oxide, nicotinamide-N-oxide), oximes ((E)-/(Z)-2,4,6-trimethylacetophenonoxime) and a N-hydroxyamidinohydrazone (guanoxabenz).	amitriptyline N-oxide	79-100	activity regulated cytoskeletal-associated protein	Mus musculus	44-48
25045021-2	2014	In this study, we tested the involvement of mARC in the reduction of N-oxides (amitriptyline-N-oxide, nicotinamide-N-oxide), oximes ((E)-/(Z)-2,4,6-trimethylacetophenonoxime) and a N-hydroxyamidinohydrazone (guanoxabenz).	nicotinamide N-oxide	102-122	activity regulated cytoskeletal-associated protein	Mus musculus	44-48
25045021-2	2014	In this study, we tested the involvement of mARC in the reduction of N-oxides (amitriptyline-N-oxide, nicotinamide-N-oxide), oximes ((E)-/(Z)-2,4,6-trimethylacetophenonoxime) and a N-hydroxyamidinohydrazone (guanoxabenz).	Oximes	125-131	activity regulated cytoskeletal-associated protein	Mus musculus	44-48
25045021-2	2014	In this study, we tested the involvement of mARC in the reduction of N-oxides (amitriptyline-N-oxide, nicotinamide-N-oxide), oximes ((E)-/(Z)-2,4,6-trimethylacetophenonoxime) and a N-hydroxyamidinohydrazone (guanoxabenz).	e)-/(z)-2,4,6-trimethylacetophenonoxime	134-173	activity regulated cytoskeletal-associated protein	Mus musculus	44-48
25045021-2	2014	In this study, we tested the involvement of mARC in the reduction of N-oxides (amitriptyline-N-oxide, nicotinamide-N-oxide), oximes ((E)-/(Z)-2,4,6-trimethylacetophenonoxime) and a N-hydroxyamidinohydrazone (guanoxabenz).	n-hydroxyamidinohydrazone	181-206	activity regulated cytoskeletal-associated protein	Mus musculus	44-48
25045021-2	2014	In this study, we tested the involvement of mARC in the reduction of N-oxides (amitriptyline-N-oxide, nicotinamide-N-oxide), oximes ((E)-/(Z)-2,4,6-trimethylacetophenonoxime) and a N-hydroxyamidinohydrazone (guanoxabenz).	guanoxabenz	208-219	activity regulated cytoskeletal-associated protein	Mus musculus	44-48
25045021-3	2014	All groups are reduced by mARC proteins, and the enzymes are therefore involved in the interconversion of N-oxygenated metabolites originating from cytochrome P450s and flavin-containing monooxygenases.	Nitrogen	106-107	activity regulated cytoskeletal-associated protein	Mus musculus	26-30
26708208-0	2016	Localized brain differences in Arc expression between mice showing low vs. high propensity to ethanol sensitization.	Ethanol	94-101	activity regulated cytoskeletal-associated protein	Mus musculus	31-34
26708208-3	2016	We examined regional brain expression of the immediate early gene activity-regulated cytoskeleton-associated protein (Arc) in order to identify brain areas in which neuroplastic changes may contribute to the development and expression of EtOH sensitization.	Ethanol	238-242	activity regulated cytoskeletal-associated protein	Mus musculus	66-116
26708208-3	2016	We examined regional brain expression of the immediate early gene activity-regulated cytoskeleton-associated protein (Arc) in order to identify brain areas in which neuroplastic changes may contribute to the development and expression of EtOH sensitization.	Ethanol	238-242	activity regulated cytoskeletal-associated protein	Mus musculus	118-121
26708208-9	2016	However in this cohort, Arc expression was significantly increased in the central amygdala (CeA) in LS mice and in SAL mice receiving EtOH for the first time.	Ethanol	134-138	activity regulated cytoskeletal-associated protein	Mus musculus	24-27
26708208-11	2016	These results indicate an acute EtOH challenge results in different patterns of Arc expression in brains of LS, HS, and SAL mice.	Ethanol	32-36	activity regulated cytoskeletal-associated protein	Mus musculus	80-83
26708208-12	2016	The dramatic increases in Arc expression in the CeA in LS and SAL mice showing little or no behavioral activation suggests that neural activity in this region may serve to inhibit the stimulant effects of EtOH.	Ethanol	205-209	activity regulated cytoskeletal-associated protein	Mus musculus	26-29
26708208-13	2016	The observation that HS mice do not show increases in Arc expression with an EtOH challenge suggests the possibility that increased tolerance to the Arc-inducing effects of EtOH may be a factor in behavioral sensitization.	Ethanol	173-177	activity regulated cytoskeletal-associated protein	Mus musculus	149-152
25897643-1	2015	A combination of electron paramagnetic resonance (EPR) spectroscopy and computational approaches has provided insight into the nature of the reaction coordinate for the one-electron reduction of nitrite by the mitochondrial amidoxime reducing component (mARC) enzyme.	Nitrites	195-202	activity regulated cytoskeletal-associated protein	Mus musculus	254-258
25897643-1	2015	A combination of electron paramagnetic resonance (EPR) spectroscopy and computational approaches has provided insight into the nature of the reaction coordinate for the one-electron reduction of nitrite by the mitochondrial amidoxime reducing component (mARC) enzyme.	amidoxime	224-233	activity regulated cytoskeletal-associated protein	Mus musculus	254-258
25897643-6	2015	A fragment orbital analysis reveals a high degree of Mo-O(H)-N-O covalency that provides a pi-orbital pathway for one-electron transfer to the substrate and defines orbital constraints on the Mo-substrate geometry for productive catalysis in mARC and other pyranopterin molybdenum enzymes that catalyze this one-electron transformation.	pyranopterin	257-269	activity regulated cytoskeletal-associated protein	Mus musculus	242-246
25453744-5	2015	The cholesterol diet reduced the levels of the "memory protein" Arc (Activity Regulated Cytoskeleton associated protein) in the hippocampus of the wildtype mice but not in the hippocampus of the Cyp27-/- mice.	Cholesterol	4-15	activity regulated cytoskeletal-associated protein	Mus musculus	69-119
25512261-0	2015	Electrochemical and mARC-catalyzed enzymatic reduction of para-substituted benzamidoximes: consequences for the prodrug concept "amidoximes instead of amidines".	amidoxime	79-89	activity regulated cytoskeletal-associated protein	Mus musculus	20-24
25512261-0	2015	Electrochemical and mARC-catalyzed enzymatic reduction of para-substituted benzamidoximes: consequences for the prodrug concept "amidoximes instead of amidines".	Amidines	151-159	activity regulated cytoskeletal-associated protein	Mus musculus	20-24
25512261-1	2015	The mitochondrial amidoxime reducing component (mARC) activates amidoxime prodrugs by reduction to the corresponding amidine drugs.	amidoxime	18-27	activity regulated cytoskeletal-associated protein	Mus musculus	48-52
25512261-1	2015	The mitochondrial amidoxime reducing component (mARC) activates amidoxime prodrugs by reduction to the corresponding amidine drugs.	amidoxime	64-73	activity regulated cytoskeletal-associated protein	Mus musculus	48-52
25512261-1	2015	The mitochondrial amidoxime reducing component (mARC) activates amidoxime prodrugs by reduction to the corresponding amidine drugs.	Amidines	117-124	activity regulated cytoskeletal-associated protein	Mus musculus	48-52
25609594-5	2014	We also found that ethanol inhibits cyclic adenosine monophosphate response element-binding protein (CREB) phosphorylation and activity-regulated cytoskeleton-associated protein (Arc) expression in neonatal and adult mice.	Ethanol	19-26	activity regulated cytoskeletal-associated protein	Mus musculus	127-177
25609594-5	2014	We also found that ethanol inhibits cyclic adenosine monophosphate response element-binding protein (CREB) phosphorylation and activity-regulated cytoskeleton-associated protein (Arc) expression in neonatal and adult mice.	Ethanol	19-26	activity regulated cytoskeletal-associated protein	Mus musculus	179-182
25609594-6	2014	The blockade or genetic deletion of CB1Rs prior to ethanol treatment at P7 rescued CREB phosphorylation and Arc expression.	Ethanol	51-58	activity regulated cytoskeletal-associated protein	Mus musculus	108-111
24915645-5	2014	Here we demonstrate that SR deficient (SR-/-) mice also have reduced Arc protein expression in the hippocampus that can be reversed with chronic D-serine administration in adulthood.	Strontium	25-27	activity regulated cytoskeletal-associated protein	Mus musculus	69-72
24915645-5	2014	Here we demonstrate that SR deficient (SR-/-) mice also have reduced Arc protein expression in the hippocampus that can be reversed with chronic D-serine administration in adulthood.	D-serine	145-153	activity regulated cytoskeletal-associated protein	Mus musculus	69-72
24915645-7	2014	These results demonstrate the importance of D-serine in regulating the hippocampal expression of Arc in vivo.	D-serine	44-52	activity regulated cytoskeletal-associated protein	Mus musculus	97-100
24915645-8	2014	In addition, our findings underscore the potential utility of using the glycine modulatory site agonist D-serine to treat disorders that exhibit Arc and dendritic spine dysregulation as a consequence of NMDAR hypofunction, such as schizophrenia.	Glycine	72-79	activity regulated cytoskeletal-associated protein	Mus musculus	145-148
24915645-8	2014	In addition, our findings underscore the potential utility of using the glycine modulatory site agonist D-serine to treat disorders that exhibit Arc and dendritic spine dysregulation as a consequence of NMDAR hypofunction, such as schizophrenia.	D-serine	104-112	activity regulated cytoskeletal-associated protein	Mus musculus	145-148
24431439-4	2014	Enhanced GABABR activity reduced the expression of immediate-early gene-encoded protein Arc/Arg3.1, effectors that are critical for long-lasting memory.	gababr	9-15	activity regulated cytoskeletal-associated protein	Mus musculus	88-98
25144769-0	2014	The N-reductive system composed of mitochondrial amidoxime reducing component (mARC), cytochrome b5 (CYB5B) and cytochrome b5 reductase (CYB5R) is regulated by fasting and high fat diet in mice.	amidoxime	49-58	activity regulated cytoskeletal-associated protein	Mus musculus	79-83
25144769-1	2014	The mitochondrial amidoxime reducing component mARC is the fourth mammalian molybdenum enzyme.	amidoxime	18-27	activity regulated cytoskeletal-associated protein	Mus musculus	47-51
25144769-12	2014	With respect to high fat diet, changes in the mARC proteins occur that result in increased N-reductive activity.	Nitrogen	91-92	activity regulated cytoskeletal-associated protein	Mus musculus	46-50
23503404-6	2013	Moreover, it is also suggested that endoplasmic reticulum (ER) stress and activity-regulated cytoskeleton associated protein (Arc) are implicated in Zn-induced degeneration of neurons.	Zinc	149-151	activity regulated cytoskeletal-associated protein	Mus musculus	74-124
24431439-7	2014	Collectively our results suggest a novel and unappreciated role for GABABR activity in determining excitatory neuronal architecture and spatial memory via their ability to regulate Arc/Arg3.1.	gababr	68-74	activity regulated cytoskeletal-associated protein	Mus musculus	181-191
22836186-0	2012	Combination of apolipoprotein E4 and high carbohydrate diet reduces hippocampal BDNF and arc levels and impairs memory in young mice.	Carbohydrates	42-54	activity regulated cytoskeletal-associated protein	Mus musculus	89-92
23086957-1	2012	The mitochondrial amidoxime-reducing component (mARC) was recently discovered as the fifth eukaryotic molybdenum cofactor-containing enzyme.	amidoxime	18-27	activity regulated cytoskeletal-associated protein	Mus musculus	48-52
22924387-0	2012	The mitochondrial Amidoxime Reducing Component (mARC) is involved in detoxification of N-hydroxylated base analogues.	amidoxime	18-27	activity regulated cytoskeletal-associated protein	Mus musculus	48-52
22924387-0	2012	The mitochondrial Amidoxime Reducing Component (mARC) is involved in detoxification of N-hydroxylated base analogues.	Nitrogen	87-88	activity regulated cytoskeletal-associated protein	Mus musculus	48-52
22924387-0	2012	The mitochondrial Amidoxime Reducing Component (mARC) is involved in detoxification of N-hydroxylated base analogues.	hydroxylated base	89-106	activity regulated cytoskeletal-associated protein	Mus musculus	48-52
22924387-1	2012	The "mitochondrial Amidoxime Reducing Component" (mARC) is the newly discovered fourth molybdenum enzyme in mammals.	amidoxime	19-28	activity regulated cytoskeletal-associated protein	Mus musculus	50-54
22924387-4	2012	Here, we demonstrate the reductive detoxification of toxic and mutagenic N-hydroxylated nucleobases and their corresponding nucleosides by the mammalian mARC-containing enzyme system.	Nitrogen	73-74	activity regulated cytoskeletal-associated protein	Mus musculus	153-157
22924387-4	2012	Here, we demonstrate the reductive detoxification of toxic and mutagenic N-hydroxylated nucleobases and their corresponding nucleosides by the mammalian mARC-containing enzyme system.	nucleobases	88-99	activity regulated cytoskeletal-associated protein	Mus musculus	153-157
22924387-4	2012	Here, we demonstrate the reductive detoxification of toxic and mutagenic N-hydroxylated nucleobases and their corresponding nucleosides by the mammalian mARC-containing enzyme system.	Nucleosides	124-135	activity regulated cytoskeletal-associated protein	Mus musculus	153-157
22924387-8	2012	On the basis of the high specific activities with N-hydroxylated base analogues relative to other N-hydroxylated substrates, our data suggest that mARC proteins might be involved in protecting cellular DNA from misincorporation of toxic N-hydroxylated base analogues during replication by converting them to the correct purine or pyrimidine bases, respectively.	Nitrogen	50-51	activity regulated cytoskeletal-associated protein	Mus musculus	147-151
22924387-8	2012	On the basis of the high specific activities with N-hydroxylated base analogues relative to other N-hydroxylated substrates, our data suggest that mARC proteins might be involved in protecting cellular DNA from misincorporation of toxic N-hydroxylated base analogues during replication by converting them to the correct purine or pyrimidine bases, respectively.	Nitrogen	98-99	activity regulated cytoskeletal-associated protein	Mus musculus	147-151
22924387-8	2012	On the basis of the high specific activities with N-hydroxylated base analogues relative to other N-hydroxylated substrates, our data suggest that mARC proteins might be involved in protecting cellular DNA from misincorporation of toxic N-hydroxylated base analogues during replication by converting them to the correct purine or pyrimidine bases, respectively.	Nitrogen	98-99	activity regulated cytoskeletal-associated protein	Mus musculus	147-151
22924387-8	2012	On the basis of the high specific activities with N-hydroxylated base analogues relative to other N-hydroxylated substrates, our data suggest that mARC proteins might be involved in protecting cellular DNA from misincorporation of toxic N-hydroxylated base analogues during replication by converting them to the correct purine or pyrimidine bases, respectively.	purine	320-326	activity regulated cytoskeletal-associated protein	Mus musculus	147-151
22924387-8	2012	On the basis of the high specific activities with N-hydroxylated base analogues relative to other N-hydroxylated substrates, our data suggest that mARC proteins might be involved in protecting cellular DNA from misincorporation of toxic N-hydroxylated base analogues during replication by converting them to the correct purine or pyrimidine bases, respectively.	pyrimidine	330-340	activity regulated cytoskeletal-associated protein	Mus musculus	147-151
11466419-0	2001	Arg3.1/Arc mRNA induction by Ca2+ and cAMP requires protein kinase A and mitogen-activated protein kinase/extracellular regulated kinase activation.	Cyclic AMP	38-42	activity regulated cytoskeletal-associated protein	Mus musculus	0-6
21627640-8	2011	Moreover, sildenafil also increased levels of brain-derived neurotrophic factor (BDNF) and the activity-regulated cytoskeletal-associated protein (Arc) in the hippocampus without any detectable modification of brain amyloid burden.	Sildenafil Citrate	10-20	activity regulated cytoskeletal-associated protein	Mus musculus	95-145
21627640-8	2011	Moreover, sildenafil also increased levels of brain-derived neurotrophic factor (BDNF) and the activity-regulated cytoskeletal-associated protein (Arc) in the hippocampus without any detectable modification of brain amyloid burden.	Sildenafil Citrate	10-20	activity regulated cytoskeletal-associated protein	Mus musculus	147-150
21976515-9	2011	Consequently, TDE altered cocaine-induced regulation of genes bearing SRE site(s) in their promoters, including c-fos, zif268, DeltaFosB, and arc/arg3.1 (activity-regulated cytoskeleton-associated protein).	Cocaine	26-33	activity regulated cytoskeletal-associated protein	Mus musculus	142-152
21471000-9	2011	N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) postsynaptic receptor stimulation led to CBF-A accumulation in dendrites; increased Arc, BDNF, and CaMKIIalpha mRNA levels; and increased amounts of transcripts coprecipitating with CBF-A.	N-Methylaspartate	0-20	activity regulated cytoskeletal-associated protein	Mus musculus	178-181
21471000-9	2011	N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) postsynaptic receptor stimulation led to CBF-A accumulation in dendrites; increased Arc, BDNF, and CaMKIIalpha mRNA levels; and increased amounts of transcripts coprecipitating with CBF-A.	N-Methylaspartate	22-26	activity regulated cytoskeletal-associated protein	Mus musculus	178-181
21471000-9	2011	N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) postsynaptic receptor stimulation led to CBF-A accumulation in dendrites; increased Arc, BDNF, and CaMKIIalpha mRNA levels; and increased amounts of transcripts coprecipitating with CBF-A.	Hydroxyl Radical	45-54	activity regulated cytoskeletal-associated protein	Mus musculus	178-181
21471000-9	2011	N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) postsynaptic receptor stimulation led to CBF-A accumulation in dendrites; increased Arc, BDNF, and CaMKIIalpha mRNA levels; and increased amounts of transcripts coprecipitating with CBF-A.	5-methyl-4-isoxazole-propionate	55-86	activity regulated cytoskeletal-associated protein	Mus musculus	178-181
21345682-7	2011	Bioactivation of N-valoxybenzamidine (1) and N,N"-bis(valoxy)pentamidine (7) via hydrolysis and reduction has been demonstrated in vitro with porcine and human subcellular enzyme preparations and the mitochondrial Amidoxime Reducing Component (mARC).	N-Valoxybenzamidine	17-36	activity regulated cytoskeletal-associated protein	Mus musculus	244-248
21345682-7	2011	Bioactivation of N-valoxybenzamidine (1) and N,N"-bis(valoxy)pentamidine (7) via hydrolysis and reduction has been demonstrated in vitro with porcine and human subcellular enzyme preparations and the mitochondrial Amidoxime Reducing Component (mARC).	N,N'-Bis(Valoxy)Pentamidine	45-72	activity regulated cytoskeletal-associated protein	Mus musculus	244-248
16211563-0	2005	Morphine activates Arc expression in the mouse striatum and in mouse neuroblastoma Neuro2A MOR1A cells expressing mu-opioid receptors.	Morphine	0-8	activity regulated cytoskeletal-associated protein	Mus musculus	19-22
16211563-3	2005	In the present experiments, the influence of morphine on Arc expression was assessed by quantitative reverse transcription real-time PCR and Western blotting in vivo in the mouse striatum/nucleus accumbens and, in vitro, in the mouse Neuro2A MOR1A cell line, expressing mu-opioid receptor.	Morphine	45-53	activity regulated cytoskeletal-associated protein	Mus musculus	57-60
16211563-4	2005	An acute administration of morphine produced a marked increase in Arc mRNA and protein level in the mouse striatum/nucleus accumbens complex.	Morphine	27-35	activity regulated cytoskeletal-associated protein	Mus musculus	66-69
16211563-5	2005	After prolonged opiate treatment, tolerance to the stimulatory effect of morphine on Arc expression developed.	Morphine	73-81	activity regulated cytoskeletal-associated protein	Mus musculus	85-88
16211563-7	2005	In Neuro2A MOR1A cells, acute, but not prolonged, morphine treatment elevated Arc mRNA level by activation of mu-opioid receptor.	Morphine	50-58	activity regulated cytoskeletal-associated protein	Mus musculus	78-81
16211563-9	2005	Inhibition experiments revealed that morphine induced Arc expression in Neuro2A MOR1A cells via intracellular signaling pathways involving mitogen-activated protein (MAP) kinases and protein kinase C. These results lend further support to the notion that stimulation of opioid receptors may exert an activating influence on some intracellular pathways and leads to induction of immediate early genes.	Morphine	37-45	activity regulated cytoskeletal-associated protein	Mus musculus	54-57
16211563-10	2005	They also demonstrate that Arc is induced in the brain in vivo after morphine administration and thus may play a role in neuroadaptations produced by the drug.	Morphine	69-77	activity regulated cytoskeletal-associated protein	Mus musculus	27-30