PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
18594856-8	2009	Collectively, these results indicate that hypergravity induces ATP release and actin reorganization via RhoA activation and FAK phosphorylation, thereby activating cell proliferation and migration in BAECs.	Adenosine Triphosphate	63-66	ras homolog family member A	Bos taurus	104-108
20019371-6	2010	Phosphorylated myosin light chain (ppMLC), a biochemical measure of actomyosin contraction, and activation of its upstream regulatory molecule RhoA-GTP were assessed by Western blot analysis.	Guanosine Triphosphate	148-151	ras homolog family member A	Bos taurus	143-147
20148651-8	2010	It opposed increase in phosphorylation of MLC and MYPT1 in response to thrombin and nocodazole, agents known to activate RhoA in the endothelium.	Nocodazole	84-94	ras homolog family member A	Bos taurus	121-125
20148651-12	2010	CONCLUSIONS: Lovastatin attenuates RhoA activation in the corneal endothelium presumably by reducing its isoprenylation.	Lovastatin	13-23	ras homolog family member A	Bos taurus	35-39
19345211-6	2009	Y-27632 (a Rho kinase inhibitor) and forskolin (known to inhibit activation of RhoA through direct elevation of cAMP) opposed the nocodazole-induced MLC phosphorylation, decrease in TER, and dispersion of ZO-1.	Y 27632	0-7	ras homolog family member A	Bos taurus	79-83
19345211-6	2009	Y-27632 (a Rho kinase inhibitor) and forskolin (known to inhibit activation of RhoA through direct elevation of cAMP) opposed the nocodazole-induced MLC phosphorylation, decrease in TER, and dispersion of ZO-1.	Colforsin	37-46	ras homolog family member A	Bos taurus	79-83
19345211-6	2009	Y-27632 (a Rho kinase inhibitor) and forskolin (known to inhibit activation of RhoA through direct elevation of cAMP) opposed the nocodazole-induced MLC phosphorylation, decrease in TER, and dispersion of ZO-1.	Cyclic AMP	112-116	ras homolog family member A	Bos taurus	79-83
19345211-6	2009	Y-27632 (a Rho kinase inhibitor) and forskolin (known to inhibit activation of RhoA through direct elevation of cAMP) opposed the nocodazole-induced MLC phosphorylation, decrease in TER, and dispersion of ZO-1.	Nocodazole	130-140	ras homolog family member A	Bos taurus	79-83
18293188-5	2008	RhoA activity was determined by affinity precipitation of RhoA-GTP to RhoA binding domain of an effector of RhoA.	Guanosine Triphosphate	63-66	ras homolog family member A	Bos taurus	0-4
18293188-5	2008	RhoA activity was determined by affinity precipitation of RhoA-GTP to RhoA binding domain of an effector of RhoA.	Guanosine Triphosphate	63-66	ras homolog family member A	Bos taurus	58-62
18293188-5	2008	RhoA activity was determined by affinity precipitation of RhoA-GTP to RhoA binding domain of an effector of RhoA.	Guanosine Triphosphate	63-66	ras homolog family member A	Bos taurus	58-62
18293188-5	2008	RhoA activity was determined by affinity precipitation of RhoA-GTP to RhoA binding domain of an effector of RhoA.	Guanosine Triphosphate	63-66	ras homolog family member A	Bos taurus	58-62
18293188-7	2008	RESULTS: Exposure to LPA (lysophosphatidic acid) led to increased MLC phosphorylation (LPA: pMLC=133%) and activation of RhoA.	lysophosphatidic acid	21-24	ras homolog family member A	Bos taurus	121-125
18293188-7	2008	RESULTS: Exposure to LPA (lysophosphatidic acid) led to increased MLC phosphorylation (LPA: pMLC=133%) and activation of RhoA.	lysophosphatidic acid	26-47	ras homolog family member A	Bos taurus	121-125
18293188-9	2008	Similarly, ET-1 and nocodazole-induced MLC phosphorylation (ET-1: pMLC=145%; nocodazole: pMLC=145%) as well as RhoA activation were suppressed by co-treatment with forskolin (ET-1+forskolin: pMLC=99%; nocodazole+forskolin: pMLC=107%).	Endothelin-1	11-15	ras homolog family member A	Bos taurus	111-115
18293188-9	2008	Similarly, ET-1 and nocodazole-induced MLC phosphorylation (ET-1: pMLC=145%; nocodazole: pMLC=145%) as well as RhoA activation were suppressed by co-treatment with forskolin (ET-1+forskolin: pMLC=99%; nocodazole+forskolin: pMLC=107%).	Nocodazole	20-30	ras homolog family member A	Bos taurus	111-115
18293188-13	2008	CONCLUSIONS: Forskolin prevents MLC phosphorylation induced by LPA, ET-1, and nocodazole through inhibition of RhoA-Rho kinase axis.	Colforsin	13-22	ras homolog family member A	Bos taurus	111-115
18596849-4	2008	We found that inhibition of isoprenylcysteine-O-carboxyl methyltransferase (ICMT) with adenosine plus homocysteine (Ado/HC) or N-acetyl-S-geranylgeranyl-L-cysteine (AGGC) decreased RhoA carboxyl methylation and activation, which correlated with decreased monolayer permeability of bovine pulmonary artery endothelial cells (BPAEC).	AGGC	127-163	ras homolog family member A	Bos taurus	181-185
17389480-3	2007	This study was conducted to examine the effects of adenosine, which is known to oppose thrombin-induced RhoA activation, thereby leading to myosin light chain dephosphorylation, on gap junctional intercellular communication and paracrine intercellular communication in cultured bovine corneal endothelial cells.	Adenosine	51-60	ras homolog family member A	Bos taurus	104-108
17460253-9	2007	However, RhoA activity was found to increase with BAK treatment.	Benzalkonium Compounds	50-53	ras homolog family member A	Bos taurus	9-13
17545156-6	2007	Stimulation of chromaffin cells with lysophosphatidic acid, a nonsecretory stimulus that strongly activates RhoA, resulted in effects on tomosyn similar to that of application of the secretagogue.	chromaffin	15-25	ras homolog family member A	Bos taurus	108-112
17545156-6	2007	Stimulation of chromaffin cells with lysophosphatidic acid, a nonsecretory stimulus that strongly activates RhoA, resulted in effects on tomosyn similar to that of application of the secretagogue.	lysophosphatidic acid	37-58	ras homolog family member A	Bos taurus	108-112
17347321-8	2007	LPA also induced a transient actin reorganization and RhoA activation.	lysophosphatidic acid	0-3	ras homolog family member A	Bos taurus	54-58
17347321-13	2007	These results indicate that LPA induces cAMP/PKA-sensitive, RhoA-mediated random migration of BTSMCs.	lysophosphatidic acid	28-31	ras homolog family member A	Bos taurus	60-64
17347321-13	2007	These results indicate that LPA induces cAMP/PKA-sensitive, RhoA-mediated random migration of BTSMCs.	Cyclic AMP	40-44	ras homolog family member A	Bos taurus	60-64
17389480-19	2007	The mechanism involves an increase in cAMP, which results in inhibition of RhoA and a subsequent decrease in myosin light chain phosphorylation.	Cyclic AMP	38-42	ras homolog family member A	Bos taurus	75-79
10564088-2	1999	We tested this hypothesis by dissociating SF/FA with Clostridium botulinum exoenzyme C3 transferase (C3), an inhibitor of the small GTP-binding protein RhoA.	Guanosine Triphosphate	132-135	ras homolog family member A	Bos taurus	152-156
17220908-11	2007	We have previously shown that HTS-induced ATP release is mediated by sequential activation of RhoA and tyrosine kinases.	Adenosine Triphosphate	42-45	ras homolog family member A	Bos taurus	94-98
17220908-14	2007	HTS-induced downstream signals of RhoA activation, i.e. the tyrosine phosphorylation of FAK and paxillin, were markedly suppressed in 7d-TGFbeta1 BAECs.	Tyrosine	60-68	ras homolog family member A	Bos taurus	34-38
16803636-8	2006	The amount of GTP-bound RhoA, that is, the active form of RhoA, decreased under this condition.	Guanosine Triphosphate	14-17	ras homolog family member A	Bos taurus	24-28
16803636-8	2006	The amount of GTP-bound RhoA, that is, the active form of RhoA, decreased under this condition.	Guanosine Triphosphate	14-17	ras homolog family member A	Bos taurus	58-62
14727521-2	2003	When the gel was pretreated with lysophosphatidic acid (LPA), which activates small G-protein RhoA, ATP- and high K+ solution-induced gel contraction was significantly augmented.	lysophosphatidic acid	33-54	ras homolog family member A	Bos taurus	94-98
14727521-2	2003	When the gel was pretreated with lysophosphatidic acid (LPA), which activates small G-protein RhoA, ATP- and high K+ solution-induced gel contraction was significantly augmented.	lysophosphatidic acid	56-59	ras homolog family member A	Bos taurus	94-98
14727521-2	2003	When the gel was pretreated with lysophosphatidic acid (LPA), which activates small G-protein RhoA, ATP- and high K+ solution-induced gel contraction was significantly augmented.	Adenosine Triphosphate	100-103	ras homolog family member A	Bos taurus	94-98
14727521-5	2003	Theophylline (> or = 1 microM) reversed the LPA-induced augmentation of gel contraction, whereas it inhibited control gel contraction only with a very high concentration (100 microM) Theophylline suppressed the LPA-induced membrane translocation of RhoA, indicating that it prevented airway hyperresponsiveness by inhibiting RhoA.	Theophylline	0-12	ras homolog family member A	Bos taurus	252-256
14727521-5	2003	Theophylline (> or = 1 microM) reversed the LPA-induced augmentation of gel contraction, whereas it inhibited control gel contraction only with a very high concentration (100 microM) Theophylline suppressed the LPA-induced membrane translocation of RhoA, indicating that it prevented airway hyperresponsiveness by inhibiting RhoA.	Theophylline	0-12	ras homolog family member A	Bos taurus	328-332
14727521-5	2003	Theophylline (> or = 1 microM) reversed the LPA-induced augmentation of gel contraction, whereas it inhibited control gel contraction only with a very high concentration (100 microM) Theophylline suppressed the LPA-induced membrane translocation of RhoA, indicating that it prevented airway hyperresponsiveness by inhibiting RhoA.	lysophosphatidic acid	47-50	ras homolog family member A	Bos taurus	252-256
14727521-5	2003	Theophylline (> or = 1 microM) reversed the LPA-induced augmentation of gel contraction, whereas it inhibited control gel contraction only with a very high concentration (100 microM) Theophylline suppressed the LPA-induced membrane translocation of RhoA, indicating that it prevented airway hyperresponsiveness by inhibiting RhoA.	lysophosphatidic acid	47-50	ras homolog family member A	Bos taurus	328-332
14727521-5	2003	Theophylline (> or = 1 microM) reversed the LPA-induced augmentation of gel contraction, whereas it inhibited control gel contraction only with a very high concentration (100 microM) Theophylline suppressed the LPA-induced membrane translocation of RhoA, indicating that it prevented airway hyperresponsiveness by inhibiting RhoA.	Theophylline	186-198	ras homolog family member A	Bos taurus	252-256
14727521-5	2003	Theophylline (> or = 1 microM) reversed the LPA-induced augmentation of gel contraction, whereas it inhibited control gel contraction only with a very high concentration (100 microM) Theophylline suppressed the LPA-induced membrane translocation of RhoA, indicating that it prevented airway hyperresponsiveness by inhibiting RhoA.	Theophylline	186-198	ras homolog family member A	Bos taurus	328-332
14727521-5	2003	Theophylline (> or = 1 microM) reversed the LPA-induced augmentation of gel contraction, whereas it inhibited control gel contraction only with a very high concentration (100 microM) Theophylline suppressed the LPA-induced membrane translocation of RhoA, indicating that it prevented airway hyperresponsiveness by inhibiting RhoA.	lysophosphatidic acid	214-217	ras homolog family member A	Bos taurus	252-256
14727521-5	2003	Theophylline (> or = 1 microM) reversed the LPA-induced augmentation of gel contraction, whereas it inhibited control gel contraction only with a very high concentration (100 microM) Theophylline suppressed the LPA-induced membrane translocation of RhoA, indicating that it prevented airway hyperresponsiveness by inhibiting RhoA.	lysophosphatidic acid	214-217	ras homolog family member A	Bos taurus	328-332
14727521-6	2003	We conclude from these results that theophylline inhibits LPA-induced, RhoA/Rho-kinase-mediated hyperresponsiveness of tracheal smooth muscle cells.	Theophylline	36-48	ras homolog family member A	Bos taurus	71-75
14727521-6	2003	We conclude from these results that theophylline inhibits LPA-induced, RhoA/Rho-kinase-mediated hyperresponsiveness of tracheal smooth muscle cells.	lysophosphatidic acid	58-61	ras homolog family member A	Bos taurus	71-75
11705946-2	2001	Here we identified second substrates for transglutamination of RhoA by DNT.	2,6-dinitrotoluene	71-74	ras homolog family member A	Bos taurus	63-67
11705946-3	2001	The enzymatically active fragment of DNT (residues 1136 to 1451, DeltaDNT) induced the incorporation of L-[(14)C]lysine in RhoA in a concentration-dependent manner.	2,6-dinitrotoluene	37-40	ras homolog family member A	Bos taurus	123-127
11705946-3	2001	The enzymatically active fragment of DNT (residues 1136 to 1451, DeltaDNT) induced the incorporation of L-[(14)C]lysine in RhoA in a concentration-dependent manner.	l-[(14)c]lysine	104-119	ras homolog family member A	Bos taurus	123-127
11705946-5	2001	Transglutamination of the GTPase with L-lysine inhibited intrinsic and Rho-GAP-stimulated GTP hydrolysis of RhoA.	Lysine	38-46	ras homolog family member A	Bos taurus	108-112
11705946-5	2001	Transglutamination of the GTPase with L-lysine inhibited intrinsic and Rho-GAP-stimulated GTP hydrolysis of RhoA.	Guanosine Triphosphate	26-29	ras homolog family member A	Bos taurus	108-112
11705946-6	2001	In contrast to lysine, treatment of RhoA with alanine, arginine, and glutamine were not able to substitute for lysine in the transglutamination reaction.	Alanine	46-53	ras homolog family member A	Bos taurus	36-40
11705946-6	2001	In contrast to lysine, treatment of RhoA with alanine, arginine, and glutamine were not able to substitute for lysine in the transglutamination reaction.	Glutamine	69-78	ras homolog family member A	Bos taurus	36-40
11705946-9	2001	A comparison of putrescine, spermidine, and lysine as substrates for DNT-induced transglutamination of RhoA revealed that lysine is a preferred second substrate at least in vitro.	Putrescine	16-26	ras homolog family member A	Bos taurus	103-107
11705946-9	2001	A comparison of putrescine, spermidine, and lysine as substrates for DNT-induced transglutamination of RhoA revealed that lysine is a preferred second substrate at least in vitro.	Spermidine	28-38	ras homolog family member A	Bos taurus	103-107
11705946-9	2001	A comparison of putrescine, spermidine, and lysine as substrates for DNT-induced transglutamination of RhoA revealed that lysine is a preferred second substrate at least in vitro.	Lysine	44-50	ras homolog family member A	Bos taurus	103-107
11705946-9	2001	A comparison of putrescine, spermidine, and lysine as substrates for DNT-induced transglutamination of RhoA revealed that lysine is a preferred second substrate at least in vitro.	2,6-dinitrotoluene	69-72	ras homolog family member A	Bos taurus	103-107
11705946-9	2001	A comparison of putrescine, spermidine, and lysine as substrates for DNT-induced transglutamination of RhoA revealed that lysine is a preferred second substrate at least in vitro.	Lysine	122-128	ras homolog family member A	Bos taurus	103-107
15208091-0	2004	KCl evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinase.	Potassium Chloride	0-3	ras homolog family member A	Bos taurus	65-69
12679373-2	2003	When the gel was pretreated with lysophosphatidic acid (LPA), which activates the small G protein RhoA, ATP- and high K+ solution-induced gel contraction was significantly augmented.	lysophosphatidic acid	33-54	ras homolog family member A	Bos taurus	98-102
12679373-2	2003	When the gel was pretreated with lysophosphatidic acid (LPA), which activates the small G protein RhoA, ATP- and high K+ solution-induced gel contraction was significantly augmented.	lysophosphatidic acid	56-59	ras homolog family member A	Bos taurus	98-102
12679373-2	2003	When the gel was pretreated with lysophosphatidic acid (LPA), which activates the small G protein RhoA, ATP- and high K+ solution-induced gel contraction was significantly augmented.	Adenosine Triphosphate	104-107	ras homolog family member A	Bos taurus	98-102
12679373-8	2003	Furthermore, theophylline, as well as dibutyryl cAMP and forskolin, suppressed the LPA-induced membrane translocation of RhoA, indicating that they prevented airway hyperresponsiveness by inhibiting RhoA.	Theophylline	13-25	ras homolog family member A	Bos taurus	121-125
12679373-8	2003	Furthermore, theophylline, as well as dibutyryl cAMP and forskolin, suppressed the LPA-induced membrane translocation of RhoA, indicating that they prevented airway hyperresponsiveness by inhibiting RhoA.	Theophylline	13-25	ras homolog family member A	Bos taurus	199-203
12679373-8	2003	Furthermore, theophylline, as well as dibutyryl cAMP and forskolin, suppressed the LPA-induced membrane translocation of RhoA, indicating that they prevented airway hyperresponsiveness by inhibiting RhoA.	dibutyryl	38-47	ras homolog family member A	Bos taurus	121-125
12679373-8	2003	Furthermore, theophylline, as well as dibutyryl cAMP and forskolin, suppressed the LPA-induced membrane translocation of RhoA, indicating that they prevented airway hyperresponsiveness by inhibiting RhoA.	Cyclic AMP	48-52	ras homolog family member A	Bos taurus	121-125
12679373-8	2003	Furthermore, theophylline, as well as dibutyryl cAMP and forskolin, suppressed the LPA-induced membrane translocation of RhoA, indicating that they prevented airway hyperresponsiveness by inhibiting RhoA.	Colforsin	57-66	ras homolog family member A	Bos taurus	121-125
12679373-8	2003	Furthermore, theophylline, as well as dibutyryl cAMP and forskolin, suppressed the LPA-induced membrane translocation of RhoA, indicating that they prevented airway hyperresponsiveness by inhibiting RhoA.	lysophosphatidic acid	83-86	ras homolog family member A	Bos taurus	121-125
12679373-8	2003	Furthermore, theophylline, as well as dibutyryl cAMP and forskolin, suppressed the LPA-induced membrane translocation of RhoA, indicating that they prevented airway hyperresponsiveness by inhibiting RhoA.	lysophosphatidic acid	83-86	ras homolog family member A	Bos taurus	199-203
12679373-9	2003	We conclude from these results that theophylline inhibits LPA-induced, RhoA/Rho-kinase-mediated hyperresponsiveness of tracheal smooth muscle cells due to the accumulation of cAMP.	Theophylline	36-48	ras homolog family member A	Bos taurus	71-75
12679373-9	2003	We conclude from these results that theophylline inhibits LPA-induced, RhoA/Rho-kinase-mediated hyperresponsiveness of tracheal smooth muscle cells due to the accumulation of cAMP.	lysophosphatidic acid	58-61	ras homolog family member A	Bos taurus	71-75
12679373-9	2003	We conclude from these results that theophylline inhibits LPA-induced, RhoA/Rho-kinase-mediated hyperresponsiveness of tracheal smooth muscle cells due to the accumulation of cAMP.	Cyclic AMP	175-179	ras homolog family member A	Bos taurus	71-75
8702419-0	1996	Involvement of rho p21 in cyclic strain-induced tyrosine phosphorylation of focal adhesion kinase (pp125FAK), morphological changes and migration of endothelial cells.	Tyrosine	48-56	ras homolog family member A	Bos taurus	19-22
8798539-3	1996	This protein interacted with guanosine 5"-(3-O-thio)triphosphate (GTPgammaS).glutathione S-transferase (GST)-Cdc42 and GTPgammaS++.GST-Rac1 but not with the GDP.GST-Cdc42, GDP.GST-Rac1, or GTPgammaS.GST-RhoA).	Guanosine 5'-O-(3-Thiotriphosphate)	29-64	ras homolog family member A	Bos taurus	203-207
8702419-3	1996	The aim of the present study was to clarify the role of the small GTP-binding protein rho p21 in EC exposed to cyclic strain.	Guanosine Triphosphate	66-69	ras homolog family member A	Bos taurus	90-93
8573175-1	1996	The GDP dissociation inhibitor Rho GDI from bovine neutrophil cytosol was purified in association with prenylated Rho A.	Guanosine Diphosphate	4-7	ras homolog family member A	Bos taurus	114-119
8641286-3	1996	This protein bound to GTPgammaS (a non-hydrolyzable GTP analog).RhoA but not to GDP.RhoA or GTPgammaS.RhoA with a mutation in the effector domain (RhoAA37).p164 had a kinase activity which was specifically stimulated by GTPgammaS.RhoA.	Guanosine Triphosphate	22-25	ras homolog family member A	Bos taurus	64-68
8224222-1	1993	The highly homologous Rho proteins RhoA, RhoB and RhoC are low-molecular-mass GTP-binding proteins.	Guanosine Triphosphate	78-81	ras homolog family member A	Bos taurus	35-39
7999019-0	1994	Role of bound GDP in the stability of the rho A-rho GDI complex purified from neutrophil cytosol.	Guanosine Diphosphate	14-17	ras homolog family member A	Bos taurus	42-47
7999019-1	1994	The rho A-rho GDI complex purified from bovine neutrophil cytosol was found to contain GDP as the only bound nucleotide at a ratio of 1 mol of GDP per mol of complex.	Guanosine Diphosphate	87-90	ras homolog family member A	Bos taurus	4-9
7999019-1	1994	The rho A-rho GDI complex purified from bovine neutrophil cytosol was found to contain GDP as the only bound nucleotide at a ratio of 1 mol of GDP per mol of complex.	Guanosine Diphosphate	143-146	ras homolog family member A	Bos taurus	4-9
7999019-3	1994	Upon dephosphorylation of bound GDP by apyrase, the rho A component of the complex was prone to proteolytic cleavage.	Guanosine Diphosphate	32-35	ras homolog family member A	Bos taurus	52-57
7999019-4	1994	The integrity of rho A in the presence of apyrase was preserved by addition of excess GTP.	Guanosine Triphosphate	86-89	ras homolog family member A	Bos taurus	17-22
7999019-5	1994	These data suggest that rho A liganded by GDP in the rho A-rho GDI complex is maintained in a conformation that escapes action of proteases.	Guanosine Diphosphate	42-45	ras homolog family member A	Bos taurus	24-29
7999019-5	1994	These data suggest that rho A liganded by GDP in the rho A-rho GDI complex is maintained in a conformation that escapes action of proteases.	Guanosine Diphosphate	42-45	ras homolog family member A	Bos taurus	53-58
1599487-1	1992	The GDP/GTP exchange reaction of rho p21, a member of ras p21-related small GTP-binding protein superfamily, is regulated by two stimulatory GDP/GTP exchange proteins (GEPs), named smg GDS and rho GDS, and by one inhibitory GEP, named rho GDI.	Guanosine Diphosphate	4-7	ras homolog family member A	Bos taurus	37-40
1599487-1	1992	The GDP/GTP exchange reaction of rho p21, a member of ras p21-related small GTP-binding protein superfamily, is regulated by two stimulatory GDP/GTP exchange proteins (GEPs), named smg GDS and rho GDS, and by one inhibitory GEP, named rho GDI.	Guanosine Diphosphate	4-7	ras homolog family member A	Bos taurus	58-61
1599487-1	1992	The GDP/GTP exchange reaction of rho p21, a member of ras p21-related small GTP-binding protein superfamily, is regulated by two stimulatory GDP/GTP exchange proteins (GEPs), named smg GDS and rho GDS, and by one inhibitory GEP, named rho GDI.	Guanosine Triphosphate	8-11	ras homolog family member A	Bos taurus	37-40
1599487-1	1992	The GDP/GTP exchange reaction of rho p21, a member of ras p21-related small GTP-binding protein superfamily, is regulated by two stimulatory GDP/GTP exchange proteins (GEPs), named smg GDS and rho GDS, and by one inhibitory GEP, named rho GDI.	Guanosine Triphosphate	8-11	ras homolog family member A	Bos taurus	58-61
1599487-1	1992	The GDP/GTP exchange reaction of rho p21, a member of ras p21-related small GTP-binding protein superfamily, is regulated by two stimulatory GDP/GTP exchange proteins (GEPs), named smg GDS and rho GDS, and by one inhibitory GEP, named rho GDI.	Guanosine Triphosphate	76-79	ras homolog family member A	Bos taurus	37-40
1599487-1	1992	The GDP/GTP exchange reaction of rho p21, a member of ras p21-related small GTP-binding protein superfamily, is regulated by two stimulatory GDP/GTP exchange proteins (GEPs), named smg GDS and rho GDS, and by one inhibitory GEP, named rho GDI.	Guanosine Triphosphate	76-79	ras homolog family member A	Bos taurus	58-61
1599487-1	1992	The GDP/GTP exchange reaction of rho p21, a member of ras p21-related small GTP-binding protein superfamily, is regulated by two stimulatory GDP/GTP exchange proteins (GEPs), named smg GDS and rho GDS, and by one inhibitory GEP, named rho GDI.	Guanosine Triphosphate	76-79	ras homolog family member A	Bos taurus	37-40
1599487-1	1992	The GDP/GTP exchange reaction of rho p21, a member of ras p21-related small GTP-binding protein superfamily, is regulated by two stimulatory GDP/GTP exchange proteins (GEPs), named smg GDS and rho GDS, and by one inhibitory GEP, named rho GDI.	Guanosine Triphosphate	76-79	ras homolog family member A	Bos taurus	58-61
1599487-2	1992	In bovine aortic smooth muscle, rho GDS and rho GDI were major GEPs for rho p21, and the rho GDI activity on the GDP/GTP exchange reaction of rho p21 was stronger than the rho GDS activity in their simultaneous presence.	Guanosine Diphosphate	113-116	ras homolog family member A	Bos taurus	146-149
1599487-2	1992	In bovine aortic smooth muscle, rho GDS and rho GDI were major GEPs for rho p21, and the rho GDI activity on the GDP/GTP exchange reaction of rho p21 was stronger than the rho GDS activity in their simultaneous presence.	Guanosine Triphosphate	117-120	ras homolog family member A	Bos taurus	146-149
1599487-3	1992	Moreover, in the crude cytosol, the GDP-bound form of rho p21 was complexed with rho GDI but not with rho GDS.	Guanosine Diphosphate	36-39	ras homolog family member A	Bos taurus	58-61
1518273-4	1992	Both the stimulatory and inhibitory GDP/GTP exchange proteins for bovine rhoA p21 were inactive for bacterial rhoA p21.	Guanosine Diphosphate	36-39	ras homolog family member A	Bos taurus	73-77
1518273-4	1992	Both the stimulatory and inhibitory GDP/GTP exchange proteins for bovine rhoA p21 were inactive for bacterial rhoA p21.	Guanosine Diphosphate	36-39	ras homolog family member A	Bos taurus	78-81
1518273-4	1992	Both the stimulatory and inhibitory GDP/GTP exchange proteins for bovine rhoA p21 were inactive for bacterial rhoA p21.	Guanosine Triphosphate	40-43	ras homolog family member A	Bos taurus	73-77
1518273-4	1992	Both the stimulatory and inhibitory GDP/GTP exchange proteins for bovine rhoA p21 were inactive for bacterial rhoA p21.	Guanosine Triphosphate	40-43	ras homolog family member A	Bos taurus	78-81
1518273-6	1992	These results indicate that the post-translational modifications of the C-terminal region of bovine rhoA p21, which are absent in bacterial rhoA p21, are essential for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins but not with the GTPase activating protein.	Guanosine Diphosphate	234-237	ras homolog family member A	Bos taurus	100-104
1518273-6	1992	These results indicate that the post-translational modifications of the C-terminal region of bovine rhoA p21, which are absent in bacterial rhoA p21, are essential for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins but not with the GTPase activating protein.	Guanosine Diphosphate	234-237	ras homolog family member A	Bos taurus	105-108
1518273-6	1992	These results indicate that the post-translational modifications of the C-terminal region of bovine rhoA p21, which are absent in bacterial rhoA p21, are essential for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins but not with the GTPase activating protein.	Guanosine Triphosphate	238-241	ras homolog family member A	Bos taurus	100-104
1518273-6	1992	These results indicate that the post-translational modifications of the C-terminal region of bovine rhoA p21, which are absent in bacterial rhoA p21, are essential for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins but not with the GTPase activating protein.	Guanosine Triphosphate	238-241	ras homolog family member A	Bos taurus	105-108
1910036-4	1991	Two types of prenyltransferase for small GTP-binding proteins have thus far been reported: ras p21 farnesyltransferase (ras p21 FT) and rhoA p21 geranylgeranyltransferase (rhoA p21 GGT).	Guanosine Triphosphate	41-44	ras homolog family member A	Bos taurus	95-98
1910036-4	1991	Two types of prenyltransferase for small GTP-binding proteins have thus far been reported: ras p21 farnesyltransferase (ras p21 FT) and rhoA p21 geranylgeranyltransferase (rhoA p21 GGT).	Guanosine Triphosphate	41-44	ras homolog family member A	Bos taurus	124-127
1910036-4	1991	Two types of prenyltransferase for small GTP-binding proteins have thus far been reported: ras p21 farnesyltransferase (ras p21 FT) and rhoA p21 geranylgeranyltransferase (rhoA p21 GGT).	Guanosine Triphosphate	41-44	ras homolog family member A	Bos taurus	136-140
1910036-4	1991	Two types of prenyltransferase for small GTP-binding proteins have thus far been reported: ras p21 farnesyltransferase (ras p21 FT) and rhoA p21 geranylgeranyltransferase (rhoA p21 GGT).	Guanosine Triphosphate	41-44	ras homolog family member A	Bos taurus	124-127
1910036-4	1991	Two types of prenyltransferase for small GTP-binding proteins have thus far been reported: ras p21 farnesyltransferase (ras p21 FT) and rhoA p21 geranylgeranyltransferase (rhoA p21 GGT).	Guanosine Triphosphate	41-44	ras homolog family member A	Bos taurus	172-176
1910036-4	1991	Two types of prenyltransferase for small GTP-binding proteins have thus far been reported: ras p21 farnesyltransferase (ras p21 FT) and rhoA p21 geranylgeranyltransferase (rhoA p21 GGT).	Guanosine Triphosphate	41-44	ras homolog family member A	Bos taurus	124-127
1905729-1	1991	rhoA p21, a ras p21-like small GTP-binding protein, has the same C-terminal consensus motif of Cys-A-A-X (A is an aliphatic amino acid and X is any amino acid) as ras p21s, which is posttranslationally processed.	Guanosine Triphosphate	31-34	ras homolog family member A	Bos taurus	0-4
1905729-1	1991	rhoA p21, a ras p21-like small GTP-binding protein, has the same C-terminal consensus motif of Cys-A-A-X (A is an aliphatic amino acid and X is any amino acid) as ras p21s, which is posttranslationally processed.	Guanosine Triphosphate	31-34	ras homolog family member A	Bos taurus	5-8
1905729-3	1991	Incubation of rhoA p21-expressing insect cells with exogenous [3H]mevalonolactone caused the labeling of rhoA p21, suggesting that rhoA p21 is prenylated.	[3h]mevalonolactone	62-81	ras homolog family member A	Bos taurus	14-18
1905729-1	1991	rhoA p21, a ras p21-like small GTP-binding protein, has the same C-terminal consensus motif of Cys-A-A-X (A is an aliphatic amino acid and X is any amino acid) as ras p21s, which is posttranslationally processed.	Guanosine Triphosphate	31-34	ras homolog family member A	Bos taurus	16-19
1905729-3	1991	Incubation of rhoA p21-expressing insect cells with exogenous [3H]mevalonolactone caused the labeling of rhoA p21, suggesting that rhoA p21 is prenylated.	[3h]mevalonolactone	62-81	ras homolog family member A	Bos taurus	19-22
1905729-1	1991	rhoA p21, a ras p21-like small GTP-binding protein, has the same C-terminal consensus motif of Cys-A-A-X (A is an aliphatic amino acid and X is any amino acid) as ras p21s, which is posttranslationally processed.	Cysteine	95-98	ras homolog family member A	Bos taurus	0-4
1905729-3	1991	Incubation of rhoA p21-expressing insect cells with exogenous [3H]mevalonolactone caused the labeling of rhoA p21, suggesting that rhoA p21 is prenylated.	[3h]mevalonolactone	62-81	ras homolog family member A	Bos taurus	105-109
1905729-3	1991	Incubation of rhoA p21-expressing insect cells with exogenous [3H]mevalonolactone caused the labeling of rhoA p21, suggesting that rhoA p21 is prenylated.	[3h]mevalonolactone	62-81	ras homolog family member A	Bos taurus	110-113
1905729-1	1991	rhoA p21, a ras p21-like small GTP-binding protein, has the same C-terminal consensus motif of Cys-A-A-X (A is an aliphatic amino acid and X is any amino acid) as ras p21s, which is posttranslationally processed.	Cysteine	95-98	ras homolog family member A	Bos taurus	5-8
1905729-3	1991	Incubation of rhoA p21-expressing insect cells with exogenous [3H]mevalonolactone caused the labeling of rhoA p21, suggesting that rhoA p21 is prenylated.	[3h]mevalonolactone	62-81	ras homolog family member A	Bos taurus	105-109
1905729-1	1991	rhoA p21, a ras p21-like small GTP-binding protein, has the same C-terminal consensus motif of Cys-A-A-X (A is an aliphatic amino acid and X is any amino acid) as ras p21s, which is posttranslationally processed.	Cysteine	95-98	ras homolog family member A	Bos taurus	16-19
1905729-3	1991	Incubation of rhoA p21-expressing insect cells with exogenous [3H]mevalonolactone caused the labeling of rhoA p21, suggesting that rhoA p21 is prenylated.	[3h]mevalonolactone	62-81	ras homolog family member A	Bos taurus	110-113
1903193-6	1991	The stimulatory GDP/GTP exchange protein for rhoA p21, named GDP dissociation stimulator (GDS), stimulated the dissociation of GDP from bovine rhoA p21, but was inactive for the bacterial protein.	Guanosine Triphosphate	20-23	ras homolog family member A	Bos taurus	148-151
1905729-4	1991	Consistently, Raney nickel treatment of rhoA p21 released a geranylgeranyl moiety as estimated by gas chromatography/mass spectrometry.	Nickel	20-26	ras homolog family member A	Bos taurus	40-44
1905729-4	1991	Consistently, Raney nickel treatment of rhoA p21 released a geranylgeranyl moiety as estimated by gas chromatography/mass spectrometry.	Nickel	20-26	ras homolog family member A	Bos taurus	45-48
1905729-4	1991	Consistently, Raney nickel treatment of rhoA p21 released a geranylgeranyl moiety as estimated by gas chromatography/mass spectrometry.	geranylgeranyl	60-74	ras homolog family member A	Bos taurus	40-44
1905729-4	1991	Consistently, Raney nickel treatment of rhoA p21 released a geranylgeranyl moiety as estimated by gas chromatography/mass spectrometry.	geranylgeranyl	60-74	ras homolog family member A	Bos taurus	45-48
1905729-6	1991	Extensive digestion of rhoA p21 with Achromobacter protease I yielded a C-terminal peptide, Ser-Gly-Cys190, that lacked the three C-terminal amino acids predicted from the cDNA but was geranylgeranylated and carboxyl methylated at the cysteine residue.	Serine	92-95	ras homolog family member A	Bos taurus	23-27
1905729-6	1991	Extensive digestion of rhoA p21 with Achromobacter protease I yielded a C-terminal peptide, Ser-Gly-Cys190, that lacked the three C-terminal amino acids predicted from the cDNA but was geranylgeranylated and carboxyl methylated at the cysteine residue.	Serine	92-95	ras homolog family member A	Bos taurus	28-31
1905729-6	1991	Extensive digestion of rhoA p21 with Achromobacter protease I yielded a C-terminal peptide, Ser-Gly-Cys190, that lacked the three C-terminal amino acids predicted from the cDNA but was geranylgeranylated and carboxyl methylated at the cysteine residue.	Glycine	96-99	ras homolog family member A	Bos taurus	23-27
1905729-6	1991	Extensive digestion of rhoA p21 with Achromobacter protease I yielded a C-terminal peptide, Ser-Gly-Cys190, that lacked the three C-terminal amino acids predicted from the cDNA but was geranylgeranylated and carboxyl methylated at the cysteine residue.	Glycine	96-99	ras homolog family member A	Bos taurus	28-31
1905729-6	1991	Extensive digestion of rhoA p21 with Achromobacter protease I yielded a C-terminal peptide, Ser-Gly-Cys190, that lacked the three C-terminal amino acids predicted from the cDNA but was geranylgeranylated and carboxyl methylated at the cysteine residue.	Cysteine	235-243	ras homolog family member A	Bos taurus	23-27
1905729-6	1991	Extensive digestion of rhoA p21 with Achromobacter protease I yielded a C-terminal peptide, Ser-Gly-Cys190, that lacked the three C-terminal amino acids predicted from the cDNA but was geranylgeranylated and carboxyl methylated at the cysteine residue.	Cysteine	235-243	ras homolog family member A	Bos taurus	28-31
1905729-8	1991	Bovine brain membranes methylated the synthetic C-terminal peptide with 10 amino acids of rhoA p21 which was geranylgeranylated at its C-terminal cysteine residue but not the peptide which was not geranylgeranylated.	Cysteine	146-154	ras homolog family member A	Bos taurus	90-94
1905729-8	1991	Bovine brain membranes methylated the synthetic C-terminal peptide with 10 amino acids of rhoA p21 which was geranylgeranylated at its C-terminal cysteine residue but not the peptide which was not geranylgeranylated.	Cysteine	146-154	ras homolog family member A	Bos taurus	95-98
1905729-9	1991	These results suggest that rhoA p21 is first geranylgeranylated followed by removal of the three C-terminal amino acids and the subsequent carboxyl methylation of the exposed cysteine residue.	Cysteine	175-183	ras homolog family member A	Bos taurus	27-31
1905729-9	1991	These results suggest that rhoA p21 is first geranylgeranylated followed by removal of the three C-terminal amino acids and the subsequent carboxyl methylation of the exposed cysteine residue.	Cysteine	175-183	ras homolog family member A	Bos taurus	32-35
1901951-0	1991	Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein.	Guanosine Diphosphate	46-49	ras homolog family member A	Bos taurus	79-82
1901951-0	1991	Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein.	Guanosine Triphosphate	50-53	ras homolog family member A	Bos taurus	79-82
1901951-0	1991	Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein.	Guanosine Triphosphate	104-107	ras homolog family member A	Bos taurus	79-82
1901951-0	1991	Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein.	Guanosine Diphosphate	162-165	ras homolog family member A	Bos taurus	79-82
1901951-0	1991	Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein.	Guanosine Triphosphate	104-107	ras homolog family member A	Bos taurus	79-82
1901951-1	1991	We have recently purified to near homogeneity the stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like GTP-binding proteins) from bovine brain cytosol.	Guanosine Diphosphate	62-65	ras homolog family member A	Bos taurus	95-98
1901951-1	1991	We have recently purified to near homogeneity the stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like GTP-binding proteins) from bovine brain cytosol.	Guanosine Triphosphate	66-69	ras homolog family member A	Bos taurus	95-98
1901951-1	1991	We have recently purified to near homogeneity the stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like GTP-binding proteins) from bovine brain cytosol.	Guanosine Triphosphate	114-117	ras homolog family member A	Bos taurus	95-98
1901951-3	1991	In this study, we have isolated and sequenced the cDNA of smg p21 GDS from a bovine brain cDNA library by using an oligonucleotide probe designed from the partial amino acid sequence of the purified smg p21 GDS.	Oligonucleotides	115-130	ras homolog family member A	Bos taurus	62-65
1901951-4	1991	The cDNA has an open reading frame encoding a protein of 558 amino acids with a calculated Mr value of 61,066, similar to the Mr of 53,000 estimated for the purified smg p21 GDS by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and sucrose density gradient ultracentrifugation.	Sodium Dodecyl Sulfate	181-203	ras homolog family member A	Bos taurus	170-173
1901951-4	1991	The cDNA has an open reading frame encoding a protein of 558 amino acids with a calculated Mr value of 61,066, similar to the Mr of 53,000 estimated for the purified smg p21 GDS by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and sucrose density gradient ultracentrifugation.	polyacrylamide	204-218	ras homolog family member A	Bos taurus	170-173
1901951-4	1991	The cDNA has an open reading frame encoding a protein of 558 amino acids with a calculated Mr value of 61,066, similar to the Mr of 53,000 estimated for the purified smg p21 GDS by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and sucrose density gradient ultracentrifugation.	Sucrose	243-250	ras homolog family member A	Bos taurus	170-173
1901951-8	1991	smg p21 GDS has low amino acid sequence homology with the yeast CDC25 and SCD25 proteins, which may regulate the GDP/GTP exchange reaction of the yeast RAS2 protein, but not with ras p21 GTPase-activating protein, the inhibitory GDP/GTP exchange proteins (GDP dissociation inhibitor) for smg p25A and rho p21s, and the beta gamma subunits of heterotrimeric GTP-binding proteins such as Gs and Gi.	Guanosine Diphosphate	113-116	ras homolog family member A	Bos taurus	4-7
1901951-8	1991	smg p21 GDS has low amino acid sequence homology with the yeast CDC25 and SCD25 proteins, which may regulate the GDP/GTP exchange reaction of the yeast RAS2 protein, but not with ras p21 GTPase-activating protein, the inhibitory GDP/GTP exchange proteins (GDP dissociation inhibitor) for smg p25A and rho p21s, and the beta gamma subunits of heterotrimeric GTP-binding proteins such as Gs and Gi.	Guanosine Triphosphate	117-120	ras homolog family member A	Bos taurus	4-7
1901951-8	1991	smg p21 GDS has low amino acid sequence homology with the yeast CDC25 and SCD25 proteins, which may regulate the GDP/GTP exchange reaction of the yeast RAS2 protein, but not with ras p21 GTPase-activating protein, the inhibitory GDP/GTP exchange proteins (GDP dissociation inhibitor) for smg p25A and rho p21s, and the beta gamma subunits of heterotrimeric GTP-binding proteins such as Gs and Gi.	Guanosine Diphosphate	229-232	ras homolog family member A	Bos taurus	4-7
1901951-8	1991	smg p21 GDS has low amino acid sequence homology with the yeast CDC25 and SCD25 proteins, which may regulate the GDP/GTP exchange reaction of the yeast RAS2 protein, but not with ras p21 GTPase-activating protein, the inhibitory GDP/GTP exchange proteins (GDP dissociation inhibitor) for smg p25A and rho p21s, and the beta gamma subunits of heterotrimeric GTP-binding proteins such as Gs and Gi.	Guanosine Diphosphate	229-232	ras homolog family member A	Bos taurus	4-7
1902224-4	1991	The final preparation showed a major protein band at Mr 28,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis and stimulated GTP hydrolysis by the purified rho A protein in a time- and dose-dependent manner.	Sodium Dodecyl Sulfate	66-88	ras homolog family member A	Bos taurus	170-175
1902224-4	1991	The final preparation showed a major protein band at Mr 28,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis and stimulated GTP hydrolysis by the purified rho A protein in a time- and dose-dependent manner.	polyacrylamide gels	89-107	ras homolog family member A	Bos taurus	170-175
1902224-4	1991	The final preparation showed a major protein band at Mr 28,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis and stimulated GTP hydrolysis by the purified rho A protein in a time- and dose-dependent manner.	Guanosine Triphosphate	139-142	ras homolog family member A	Bos taurus	170-175
1903193-4	1991	The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it.	Guanosine Diphosphate	15-18	ras homolog family member A	Bos taurus	49-52
1903193-4	1991	The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it.	Guanosine Diphosphate	15-18	ras homolog family member A	Bos taurus	148-151
1903193-4	1991	The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it.	Guanosine Triphosphate	19-22	ras homolog family member A	Bos taurus	49-52
1903193-4	1991	The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it.	Guanosine Triphosphate	19-22	ras homolog family member A	Bos taurus	148-151
1903193-4	1991	The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it.	Guanosine Diphosphate	60-63	ras homolog family member A	Bos taurus	49-52
1903193-4	1991	The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it.	Guanosine Diphosphate	60-63	ras homolog family member A	Bos taurus	148-151
1903193-4	1991	The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it.	Guanosine Diphosphate	60-63	ras homolog family member A	Bos taurus	49-52
1903193-4	1991	The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it.	Guanosine Diphosphate	60-63	ras homolog family member A	Bos taurus	148-151
1903193-4	1991	The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it.	Guanosine Diphosphate	60-63	ras homolog family member A	Bos taurus	49-52
1903193-4	1991	The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it.	Guanosine Diphosphate	60-63	ras homolog family member A	Bos taurus	148-151
1903193-4	1991	The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it.	Guanosine Triphosphate	233-236	ras homolog family member A	Bos taurus	49-52
1903193-4	1991	The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it.	Guanosine Triphosphate	233-236	ras homolog family member A	Bos taurus	148-151
1903193-5	1991	However, rho GDI neither made a complex with the GDP-bound form of bacterial rhoA p21 nor affected these reactions of the bacterial protein.	Guanosine Diphosphate	49-52	ras homolog family member A	Bos taurus	82-85
1903193-6	1991	The stimulatory GDP/GTP exchange protein for rhoA p21, named GDP dissociation stimulator (GDS), stimulated the dissociation of GDP from bovine rhoA p21, but was inactive for the bacterial protein.	Guanosine Diphosphate	16-19	ras homolog family member A	Bos taurus	50-53
1903193-6	1991	The stimulatory GDP/GTP exchange protein for rhoA p21, named GDP dissociation stimulator (GDS), stimulated the dissociation of GDP from bovine rhoA p21, but was inactive for the bacterial protein.	Guanosine Diphosphate	16-19	ras homolog family member A	Bos taurus	148-151
1903193-6	1991	The stimulatory GDP/GTP exchange protein for rhoA p21, named GDP dissociation stimulator (GDS), stimulated the dissociation of GDP from bovine rhoA p21, but was inactive for the bacterial protein.	Guanosine Triphosphate	20-23	ras homolog family member A	Bos taurus	50-53
1903193-6	1991	The stimulatory GDP/GTP exchange protein for rhoA p21, named GDP dissociation stimulator (GDS), stimulated the dissociation of GDP from bovine rhoA p21, but was inactive for the bacterial protein.	Guanosine Diphosphate	61-64	ras homolog family member A	Bos taurus	50-53
1903193-6	1991	The stimulatory GDP/GTP exchange protein for rhoA p21, named GDP dissociation stimulator (GDS), stimulated the dissociation of GDP from bovine rhoA p21, but was inactive for the bacterial protein.	Guanosine Diphosphate	61-64	ras homolog family member A	Bos taurus	148-151
1903193-6	1991	The stimulatory GDP/GTP exchange protein for rhoA p21, named GDP dissociation stimulator (GDS), stimulated the dissociation of GDP from bovine rhoA p21, but was inactive for the bacterial protein.	Guanosine Diphosphate	61-64	ras homolog family member A	Bos taurus	50-53
1903193-6	1991	The stimulatory GDP/GTP exchange protein for rhoA p21, named GDP dissociation stimulator (GDS), stimulated the dissociation of GDP from bovine rhoA p21, but was inactive for the bacterial protein.	Guanosine Diphosphate	61-64	ras homolog family member A	Bos taurus	148-151
1903193-8	1991	These results suggest that the post-translational modifications of the C-terminal region of bovine rhoA p21, most presumably the geranylgeranylation, which are absent in bacterial rhoA p21, play important roles in its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins but not with the GAP.	Guanosine Diphosphate	280-283	ras homolog family member A	Bos taurus	104-107
1903193-8	1991	These results suggest that the post-translational modifications of the C-terminal region of bovine rhoA p21, most presumably the geranylgeranylation, which are absent in bacterial rhoA p21, play important roles in its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins but not with the GAP.	Guanosine Triphosphate	284-287	ras homolog family member A	Bos taurus	104-107
2123802-0	1990	Interaction of recombinant rho A GTP-binding proteins with photoexcited rhodopsin.	Guanosine Triphosphate	33-36	ras homolog family member A	Bos taurus	27-32
1902099-1	1991	We have clarified that rhoA p21 purified from bovine aortic smooth muscle is geranylgeranylated at the cysteine residue in the C-terminal CAAX motif (A is an aliphatic amino acid and X is any amino acid).	Cysteine	103-111	ras homolog family member A	Bos taurus	23-27
1902099-1	1991	We have clarified that rhoA p21 purified from bovine aortic smooth muscle is geranylgeranylated at the cysteine residue in the C-terminal CAAX motif (A is an aliphatic amino acid and X is any amino acid).	Cysteine	103-111	ras homolog family member A	Bos taurus	28-31
1902099-1	1991	We have clarified that rhoA p21 purified from bovine aortic smooth muscle is geranylgeranylated at the cysteine residue in the C-terminal CAAX motif (A is an aliphatic amino acid and X is any amino acid).	aliphatic amino acid	158-178	ras homolog family member A	Bos taurus	23-27
1902099-1	1991	We have clarified that rhoA p21 purified from bovine aortic smooth muscle is geranylgeranylated at the cysteine residue in the C-terminal CAAX motif (A is an aliphatic amino acid and X is any amino acid).	aliphatic amino acid	158-178	ras homolog family member A	Bos taurus	28-31
1902099-3	1991	This enzyme transferred a geranylgeranyl moiety from geranylgeranyl pyrophosphate to rhoA p21 having the CAAX motif (rhoA p21-CAAX) but not to rhoA p21 lacking the AAX portion.	geranylgeranyl	26-40	ras homolog family member A	Bos taurus	85-89
1902099-3	1991	This enzyme transferred a geranylgeranyl moiety from geranylgeranyl pyrophosphate to rhoA p21 having the CAAX motif (rhoA p21-CAAX) but not to rhoA p21 lacking the AAX portion.	geranylgeranyl	26-40	ras homolog family member A	Bos taurus	90-93
1902099-3	1991	This enzyme transferred a geranylgeranyl moiety from geranylgeranyl pyrophosphate to rhoA p21 having the CAAX motif (rhoA p21-CAAX) but not to rhoA p21 lacking the AAX portion.	geranylgeranyl	26-40	ras homolog family member A	Bos taurus	117-121
1902099-3	1991	This enzyme transferred a geranylgeranyl moiety from geranylgeranyl pyrophosphate to rhoA p21 having the CAAX motif (rhoA p21-CAAX) but not to rhoA p21 lacking the AAX portion.	geranylgeranyl	26-40	ras homolog family member A	Bos taurus	122-125
1902099-3	1991	This enzyme transferred a geranylgeranyl moiety from geranylgeranyl pyrophosphate to rhoA p21 having the CAAX motif (rhoA p21-CAAX) but not to rhoA p21 lacking the AAX portion.	geranylgeranyl	26-40	ras homolog family member A	Bos taurus	117-121
1902099-3	1991	This enzyme transferred a geranylgeranyl moiety from geranylgeranyl pyrophosphate to rhoA p21 having the CAAX motif (rhoA p21-CAAX) but not to rhoA p21 lacking the AAX portion.	geranylgeranyl	26-40	ras homolog family member A	Bos taurus	122-125
1902099-3	1991	This enzyme transferred a geranylgeranyl moiety from geranylgeranyl pyrophosphate to rhoA p21 having the CAAX motif (rhoA p21-CAAX) but not to rhoA p21 lacking the AAX portion.	geranylgeranyl pyrophosphate	53-81	ras homolog family member A	Bos taurus	85-89
1902099-3	1991	This enzyme transferred a geranylgeranyl moiety from geranylgeranyl pyrophosphate to rhoA p21 having the CAAX motif (rhoA p21-CAAX) but not to rhoA p21 lacking the AAX portion.	geranylgeranyl pyrophosphate	53-81	ras homolog family member A	Bos taurus	90-93
1902099-3	1991	This enzyme transferred a geranylgeranyl moiety from geranylgeranyl pyrophosphate to rhoA p21 having the CAAX motif (rhoA p21-CAAX) but not to rhoA p21 lacking the AAX portion.	geranylgeranyl pyrophosphate	53-81	ras homolog family member A	Bos taurus	117-121
1902099-3	1991	This enzyme transferred a geranylgeranyl moiety from geranylgeranyl pyrophosphate to rhoA p21 having the CAAX motif (rhoA p21-CAAX) but not to rhoA p21 lacking the AAX portion.	geranylgeranyl pyrophosphate	53-81	ras homolog family member A	Bos taurus	122-125
1902099-3	1991	This enzyme transferred a geranylgeranyl moiety from geranylgeranyl pyrophosphate to rhoA p21 having the CAAX motif (rhoA p21-CAAX) but not to rhoA p21 lacking the AAX portion.	geranylgeranyl pyrophosphate	53-81	ras homolog family member A	Bos taurus	117-121
1902099-3	1991	This enzyme transferred a geranylgeranyl moiety from geranylgeranyl pyrophosphate to rhoA p21 having the CAAX motif (rhoA p21-CAAX) but not to rhoA p21 lacking the AAX portion.	geranylgeranyl pyrophosphate	53-81	ras homolog family member A	Bos taurus	122-125
2174426-3	1990	Amino acid sequences of tryptic peptides from the two substrates were identical to rhoA and rhoB; hence, the purified proteins are referred to as rhoA* and rhoB*, respectively.	Peptides	32-40	ras homolog family member A	Bos taurus	83-87
2174426-3	1990	Amino acid sequences of tryptic peptides from the two substrates were identical to rhoA and rhoB; hence, the purified proteins are referred to as rhoA* and rhoB*, respectively.	Peptides	32-40	ras homolog family member A	Bos taurus	146-151
2174426-5	1990	In contrast to other C3 substrates, rhoA* behaved as a 77-80-kDa protein on gel filtration, although on sodium dodecyl sulfate-polyacrylamide gel electrophoresis the ADP-ribosylated moiety had a mobility consistent with a 21.5-kDa protein.	Sodium Dodecyl Sulfate	104-126	ras homolog family member A	Bos taurus	36-40
2174426-5	1990	In contrast to other C3 substrates, rhoA* behaved as a 77-80-kDa protein on gel filtration, although on sodium dodecyl sulfate-polyacrylamide gel electrophoresis the ADP-ribosylated moiety had a mobility consistent with a 21.5-kDa protein.	polyacrylamide	127-141	ras homolog family member A	Bos taurus	36-40
2174426-6	1990	Furthermore, C3-catalyzed ADP-ribosylation of rhoA* was dependent on guanine nucleotides in the presence of 1 mM Mg2+ or 1 mM EDTA (0.19 microM free Mg2+).	Adenosine Diphosphate	26-29	ras homolog family member A	Bos taurus	46-51
2174426-6	1990	Furthermore, C3-catalyzed ADP-ribosylation of rhoA* was dependent on guanine nucleotides in the presence of 1 mM Mg2+ or 1 mM EDTA (0.19 microM free Mg2+).	Guanine Nucleotides	69-88	ras homolog family member A	Bos taurus	46-51
2174426-6	1990	Furthermore, C3-catalyzed ADP-ribosylation of rhoA* was dependent on guanine nucleotides in the presence of 1 mM Mg2+ or 1 mM EDTA (0.19 microM free Mg2+).	magnesium ion	113-117	ras homolog family member A	Bos taurus	46-51
2174426-6	1990	Furthermore, C3-catalyzed ADP-ribosylation of rhoA* was dependent on guanine nucleotides in the presence of 1 mM Mg2+ or 1 mM EDTA (0.19 microM free Mg2+).	Edetic Acid	126-130	ras homolog family member A	Bos taurus	46-51
2174426-6	1990	Furthermore, C3-catalyzed ADP-ribosylation of rhoA* was dependent on guanine nucleotides in the presence of 1 mM Mg2+ or 1 mM EDTA (0.19 microM free Mg2+).	magnesium ion	149-153	ras homolog family member A	Bos taurus	46-51
2174426-9	1990	This increase in ADP-ribosylation was specific for rhoA*; it was not observed with rhoB* and has not been reported for other C3 substrates.	Adenosine Diphosphate	17-20	ras homolog family member A	Bos taurus	51-55
2123802-1	1990	The small molecular mass GTP-binding proteins rho A, B and C are targets for ADP-ribosyltransferase activity of the botulinum exoenzyme C3.	Guanosine Triphosphate	25-28	ras homolog family member A	Bos taurus	46-51
2123802-2	1990	The possible interaction of recombinant rho A proteins expressed in E. coli with photoexcited rhodopsin was studied by reconstitution with bovine rod outer segment (ROS) membranes depleted of endogenous GTP-binding proteins by treatment with urea.	Guanosine Triphosphate	203-206	ras homolog family member A	Bos taurus	40-45
2123802-2	1990	The possible interaction of recombinant rho A proteins expressed in E. coli with photoexcited rhodopsin was studied by reconstitution with bovine rod outer segment (ROS) membranes depleted of endogenous GTP-binding proteins by treatment with urea.	Urea	242-246	ras homolog family member A	Bos taurus	40-45
2123802-3	1990	As reported for C3 substrates present in untreated ROS membranes, ADP-ribosylation of recombinant rho A proteins, both normal and Val-14 mutant, by C3 was inhibited when reconstituted with illuminated compared to dark-adapted ROS membranes pretreated with urea.	Adenosine Diphosphate	66-69	ras homolog family member A	Bos taurus	98-103
2123802-3	1990	As reported for C3 substrates present in untreated ROS membranes, ADP-ribosylation of recombinant rho A proteins, both normal and Val-14 mutant, by C3 was inhibited when reconstituted with illuminated compared to dark-adapted ROS membranes pretreated with urea.	Valine	130-133	ras homolog family member A	Bos taurus	98-103
2123802-3	1990	As reported for C3 substrates present in untreated ROS membranes, ADP-ribosylation of recombinant rho A proteins, both normal and Val-14 mutant, by C3 was inhibited when reconstituted with illuminated compared to dark-adapted ROS membranes pretreated with urea.	Urea	256-260	ras homolog family member A	Bos taurus	98-103
2123802-4	1990	GDP reduced the light-induced inhibition, while GTP[S] and light inhibited ADP-ribosylation of rho A proteins in a synergistic manner.	Guanosine Diphosphate	0-3	ras homolog family member A	Bos taurus	95-100
2123802-4	1990	GDP reduced the light-induced inhibition, while GTP[S] and light inhibited ADP-ribosylation of rho A proteins in a synergistic manner.	Guanosine Triphosphate	48-51	ras homolog family member A	Bos taurus	95-100
2123802-4	1990	GDP reduced the light-induced inhibition, while GTP[S] and light inhibited ADP-ribosylation of rho A proteins in a synergistic manner.	Adenosine Diphosphate	75-78	ras homolog family member A	Bos taurus	95-100
2116795-0	1990	Identification of a major GTP-binding protein in bovine aortic smooth muscle cytosol as the rhoA gene product.	Guanosine Triphosphate	26-29	ras homolog family member A	Bos taurus	92-96
2172971-1	1990	We have previously identified a membrane factor capable of stimulating guanine nucleotide exchange activity for ras p21 proteins.	Guanine Nucleotides	71-89	ras homolog family member A	Bos taurus	116-119
2172971-4	1990	rGEF increased the exchange rate of GDP in normal [Gly12]p21 or oncogenic [Val12]p21 up to 30- to 40-fold under physiological concentrations of Mg2+.	Guanosine Diphosphate	36-39	ras homolog family member A	Bos taurus	57-60
2172971-4	1990	rGEF increased the exchange rate of GDP in normal [Gly12]p21 or oncogenic [Val12]p21 up to 30- to 40-fold under physiological concentrations of Mg2+.	Guanosine Diphosphate	36-39	ras homolog family member A	Bos taurus	81-84
2118909-0	1990	Purification and characterization from bovine brain cytosol of proteins that regulate the GDP/GTP exchange reaction of smg p21s, ras p21-like GTP-binding proteins.	Guanosine Diphosphate	90-93	ras homolog family member A	Bos taurus	123-126
2118909-0	1990	Purification and characterization from bovine brain cytosol of proteins that regulate the GDP/GTP exchange reaction of smg p21s, ras p21-like GTP-binding proteins.	Guanosine Triphosphate	94-97	ras homolog family member A	Bos taurus	123-126
2118909-0	1990	Purification and characterization from bovine brain cytosol of proteins that regulate the GDP/GTP exchange reaction of smg p21s, ras p21-like GTP-binding proteins.	Guanosine Triphosphate	142-145	ras homolog family member A	Bos taurus	123-126
2118909-3	1990	smg p21 GDS1 and -2 also stimulated the binding of [35S]GTP gamma S to the GDP-bound form of smg p21s but not that to the guanine nucleotide-free form.	Sulfur-35	52-55	ras homolog family member A	Bos taurus	4-7
2118909-3	1990	smg p21 GDS1 and -2 also stimulated the binding of [35S]GTP gamma S to the GDP-bound form of smg p21s but not that to the guanine nucleotide-free form.	Guanosine Triphosphate	56-59	ras homolog family member A	Bos taurus	4-7
2118909-3	1990	smg p21 GDS1 and -2 also stimulated the binding of [35S]GTP gamma S to the GDP-bound form of smg p21s but not that to the guanine nucleotide-free form.	Guanosine Diphosphate	75-78	ras homolog family member A	Bos taurus	4-7
2118909-3	1990	smg p21 GDS1 and -2 also stimulated the binding of [35S]GTP gamma S to the GDP-bound form of smg p21s but not that to the guanine nucleotide-free form.	Guanine Nucleotides	122-140	ras homolog family member A	Bos taurus	4-7
2118909-7	1990	The Mr values of smg p21 GDS1 and -2 were estimated to be about 53,000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and from the S values, indicating that smg p21 GDS1 and -2 are composed of a single polypeptide without a subunit structure.	Sodium Dodecyl Sulfate	74-96	ras homolog family member A	Bos taurus	21-24
2118909-7	1990	The Mr values of smg p21 GDS1 and -2 were estimated to be about 53,000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and from the S values, indicating that smg p21 GDS1 and -2 are composed of a single polypeptide without a subunit structure.	Sodium Dodecyl Sulfate	74-96	ras homolog family member A	Bos taurus	175-178
2118909-7	1990	The Mr values of smg p21 GDS1 and -2 were estimated to be about 53,000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and from the S values, indicating that smg p21 GDS1 and -2 are composed of a single polypeptide without a subunit structure.	polyacrylamide	97-111	ras homolog family member A	Bos taurus	21-24
2118909-7	1990	The Mr values of smg p21 GDS1 and -2 were estimated to be about 53,000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and from the S values, indicating that smg p21 GDS1 and -2 are composed of a single polypeptide without a subunit structure.	polyacrylamide	97-111	ras homolog family member A	Bos taurus	175-178
2118909-9	1990	These results indicate that bovine brain contains regulatory proteins for smg p21s that stimulate the dissociation of GDP from and thereby the subsequent binding of GTP to smg p21s in addition to smg p21 GAP.	Guanosine Diphosphate	118-121	ras homolog family member A	Bos taurus	78-81
2118909-9	1990	These results indicate that bovine brain contains regulatory proteins for smg p21s that stimulate the dissociation of GDP from and thereby the subsequent binding of GTP to smg p21s in addition to smg p21 GAP.	Guanosine Diphosphate	118-121	ras homolog family member A	Bos taurus	176-179
2118909-9	1990	These results indicate that bovine brain contains regulatory proteins for smg p21s that stimulate the dissociation of GDP from and thereby the subsequent binding of GTP to smg p21s in addition to smg p21 GAP.	Guanosine Triphosphate	165-168	ras homolog family member A	Bos taurus	78-81
2118909-9	1990	These results indicate that bovine brain contains regulatory proteins for smg p21s that stimulate the dissociation of GDP from and thereby the subsequent binding of GTP to smg p21s in addition to smg p21 GAP.	Guanosine Triphosphate	165-168	ras homolog family member A	Bos taurus	176-179
2118909-10	1990	It is likely that the conversion from the GDP-bound inactive form of smg p21s to the GTP-bound active form is regulated by smg p21 GDS and that its reverse reaction is regulated by smg p21 GAP.	Guanosine Diphosphate	42-45	ras homolog family member A	Bos taurus	73-76
2118909-10	1990	It is likely that the conversion from the GDP-bound inactive form of smg p21s to the GTP-bound active form is regulated by smg p21 GDS and that its reverse reaction is regulated by smg p21 GAP.	Guanosine Diphosphate	42-45	ras homolog family member A	Bos taurus	127-130
2118909-10	1990	It is likely that the conversion from the GDP-bound inactive form of smg p21s to the GTP-bound active form is regulated by smg p21 GDS and that its reverse reaction is regulated by smg p21 GAP.	Guanosine Diphosphate	42-45	ras homolog family member A	Bos taurus	127-130
2118909-10	1990	It is likely that the conversion from the GDP-bound inactive form of smg p21s to the GTP-bound active form is regulated by smg p21 GDS and that its reverse reaction is regulated by smg p21 GAP.	Guanosine Triphosphate	85-88	ras homolog family member A	Bos taurus	73-76
2118909-10	1990	It is likely that the conversion from the GDP-bound inactive form of smg p21s to the GTP-bound active form is regulated by smg p21 GDS and that its reverse reaction is regulated by smg p21 GAP.	Guanosine Triphosphate	85-88	ras homolog family member A	Bos taurus	127-130
2118909-10	1990	It is likely that the conversion from the GDP-bound inactive form of smg p21s to the GTP-bound active form is regulated by smg p21 GDS and that its reverse reaction is regulated by smg p21 GAP.	Guanosine Triphosphate	85-88	ras homolog family member A	Bos taurus	127-130
2111820-0	1990	Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein.	Guanosine Diphosphate	121-124	ras homolog family member A	Bos taurus	183-186
2113382-1	1990	A novel type of regulatory proteins for the rho proteins (rhoA p21 and rhoB p20), ras p21-like small GTP-binding proteins (G proteins), are partially purified from bovine brain cytosol.	Guanosine Triphosphate	101-104	ras homolog family member A	Bos taurus	86-89
2113382-2	1990	These regulatory proteins, named rho GDP dissociation stimulator (GDS) 1 and -2, stimulate the dissociation of GDP from rhoA p21 and rhoB p20.	Guanosine Diphosphate	37-40	ras homolog family member A	Bos taurus	125-128
2113382-2	1990	These regulatory proteins, named rho GDP dissociation stimulator (GDS) 1 and -2, stimulate the dissociation of GDP from rhoA p21 and rhoB p20.	Guanosine Diphosphate	111-114	ras homolog family member A	Bos taurus	125-128
2111820-0	1990	Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein.	Guanosine Triphosphate	160-163	ras homolog family member A	Bos taurus	183-186
34635355-12	2022	Accordingly, BHB treatment increased the phosphorylation level of PKC and MLC2, the protein abundance of RhoA and rho-kinase 1 (ROCK1), and the mRNA abundance of PRKCA, MYL2, RHOA, and ROCK1 in PMN.	3-Hydroxybutyric Acid	13-16	ras homolog family member A	Bos taurus	105-109
34635355-12	2022	Accordingly, BHB treatment increased the phosphorylation level of PKC and MLC2, the protein abundance of RhoA and rho-kinase 1 (ROCK1), and the mRNA abundance of PRKCA, MYL2, RHOA, and ROCK1 in PMN.	3-Hydroxybutyric Acid	13-16	ras homolog family member A	Bos taurus	175-179
2542301-0	1989	Purification and characterization from bovine brain cytosol of two GTPase-activating proteins specific for smg p21, a GTP-binding protein having the same effector domain as c-ras p21s.	Guanosine Triphosphate	67-70	ras homolog family member A	Bos taurus	111-114
2515409-1	1989	We have purified to near homogeneity and characterized three small molecular weight (Mr) GTP-binding proteins, the c-Ki-ras protein (c-Ki-ras p21), the rho protein (rho p20) and a novel smg-25A protein (smg p25A), from bovine brain crude membranes.	Guanosine Triphosphate	89-92	ras homolog family member A	Bos taurus	142-145
2542301-4	1989	smg p21 GAP1 and -2 stimulate the GTPase activity of only smg p21 but not that of c-Ha-ras p21 or the rho and smg-25A GTP-binding proteins.	Guanosine Triphosphate	34-37	ras homolog family member A	Bos taurus	4-7
2542301-4	1989	smg p21 GAP1 and -2 stimulate the GTPase activity of only smg p21 but not that of c-Ha-ras p21 or the rho and smg-25A GTP-binding proteins.	Guanosine Triphosphate	34-37	ras homolog family member A	Bos taurus	62-65
2542301-4	1989	smg p21 GAP1 and -2 stimulate the GTPase activity of only smg p21 but not that of c-Ha-ras p21 or the rho and smg-25A GTP-binding proteins.	Guanosine Triphosphate	34-37	ras homolog family member A	Bos taurus	62-65
2542301-7	1989	The Mr values of smg p21 GAP1 and -2 are estimated to be 250-400 x 10(3) and 80-100 x 10(3) by gel filtration and sucrose density gradient ultracentrifugation, respectively.	Sucrose	114-121	ras homolog family member A	Bos taurus	21-24
25387906-4	2014	Further experiments revealed that HSS decreased RhoA activity, with a constitutively active RhoA mutant inhibiting while a negative RhoA mutant enhancing the HSS-induced Src polarity.	hepatic stimulator substance	34-37	ras homolog family member A	Bos taurus	48-52
3143720-2	1988	In the present studies, we have purified a novel small Mr GTP-binding protein, designated as smg p21, to near homogeneity from bovine brain crude membranes, isolated the complementary DNA (cDNA) of this protein from a bovine brain cDNA library, determined the complete nucleotide and deduced amino acid sequences, and characterized the kinetic properties.	Guanosine Triphosphate	58-61	ras homolog family member A	Bos taurus	97-100
3143720-4	1988	The Mr of purified smg p21 is estimated to be about 22,000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	Sodium Dodecyl Sulfate	62-84	ras homolog family member A	Bos taurus	23-26
3143720-4	1988	The Mr of purified smg p21 is estimated to be about 22,000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	polyacrylamide gels	85-103	ras homolog family member A	Bos taurus	23-26
3143720-7	1988	Consistent with these structural properties, smg p21 binds specifically [35S] guanosine 5"-(3-O-thio)triphosphate (GTP gamma S), GTP, and GDP with a Kd value for GTP gamma S of about 40 nM.	Sulfur-35	73-76	ras homolog family member A	Bos taurus	49-52
3143720-7	1988	Consistent with these structural properties, smg p21 binds specifically [35S] guanosine 5"-(3-O-thio)triphosphate (GTP gamma S), GTP, and GDP with a Kd value for GTP gamma S of about 40 nM.	Guanosine 5'-O-(3-Thiotriphosphate)	78-113	ras homolog family member A	Bos taurus	49-52
3143720-7	1988	Consistent with these structural properties, smg p21 binds specifically [35S] guanosine 5"-(3-O-thio)triphosphate (GTP gamma S), GTP, and GDP with a Kd value for GTP gamma S of about 40 nM.	Guanosine Triphosphate	115-118	ras homolog family member A	Bos taurus	49-52
3143720-7	1988	Consistent with these structural properties, smg p21 binds specifically [35S] guanosine 5"-(3-O-thio)triphosphate (GTP gamma S), GTP, and GDP with a Kd value for GTP gamma S of about 40 nM.	Guanosine Triphosphate	129-132	ras homolog family member A	Bos taurus	49-52
3143720-7	1988	Consistent with these structural properties, smg p21 binds specifically [35S] guanosine 5"-(3-O-thio)triphosphate (GTP gamma S), GTP, and GDP with a Kd value for GTP gamma S of about 40 nM.	Guanosine Diphosphate	138-141	ras homolog family member A	Bos taurus	49-52
3143720-7	1988	Consistent with these structural properties, smg p21 binds specifically [35S] guanosine 5"-(3-O-thio)triphosphate (GTP gamma S), GTP, and GDP with a Kd value for GTP gamma S of about 40 nM.	Guanosine Triphosphate	129-132	ras homolog family member A	Bos taurus	49-52
3143720-8	1988	smg p21 binds about 0.7 mol of GTP gamma S/mol of protein.	Guanosine Triphosphate	31-34	ras homolog family member A	Bos taurus	4-7
3143720-9	1988	[35S]GTP gamma S-binding to smg p21 is inhibited by pretreatment with N-ethylmaleimide.smg p21 hydrolyzes GTP to liberate Pi with a turnover number of about 0.007 min-1.	Sulfur-35	1-4	ras homolog family member A	Bos taurus	32-35
3143720-9	1988	[35S]GTP gamma S-binding to smg p21 is inhibited by pretreatment with N-ethylmaleimide.smg p21 hydrolyzes GTP to liberate Pi with a turnover number of about 0.007 min-1.	Sulfur-35	1-4	ras homolog family member A	Bos taurus	91-94
3143720-9	1988	[35S]GTP gamma S-binding to smg p21 is inhibited by pretreatment with N-ethylmaleimide.smg p21 hydrolyzes GTP to liberate Pi with a turnover number of about 0.007 min-1.	Guanosine Triphosphate	5-8	ras homolog family member A	Bos taurus	32-35
3143720-9	1988	[35S]GTP gamma S-binding to smg p21 is inhibited by pretreatment with N-ethylmaleimide.smg p21 hydrolyzes GTP to liberate Pi with a turnover number of about 0.007 min-1.	Guanosine Triphosphate	5-8	ras homolog family member A	Bos taurus	91-94
3143720-9	1988	[35S]GTP gamma S-binding to smg p21 is inhibited by pretreatment with N-ethylmaleimide.smg p21 hydrolyzes GTP to liberate Pi with a turnover number of about 0.007 min-1.	Ethylmaleimide	70-86	ras homolog family member A	Bos taurus	32-35
3143720-9	1988	[35S]GTP gamma S-binding to smg p21 is inhibited by pretreatment with N-ethylmaleimide.smg p21 hydrolyzes GTP to liberate Pi with a turnover number of about 0.007 min-1.	Ethylmaleimide	70-86	ras homolog family member A	Bos taurus	91-94
3143720-9	1988	[35S]GTP gamma S-binding to smg p21 is inhibited by pretreatment with N-ethylmaleimide.smg p21 hydrolyzes GTP to liberate Pi with a turnover number of about 0.007 min-1.	Guanosine Triphosphate	106-109	ras homolog family member A	Bos taurus	32-35
3143720-9	1988	[35S]GTP gamma S-binding to smg p21 is inhibited by pretreatment with N-ethylmaleimide.smg p21 hydrolyzes GTP to liberate Pi with a turnover number of about 0.007 min-1.	Guanosine Triphosphate	106-109	ras homolog family member A	Bos taurus	91-94
3143720-11	1988	These results suggest that smg p21 is a novel GTP-binding protein exerting action(s) similar or antagonistic to that (those) of the ras proteins.	Guanosine Triphosphate	46-49	ras homolog family member A	Bos taurus	31-34
2842690-2	1988	Oncogenic ras p21 variants result from amino acid substitutions at specific positions that cause p21 to occur predominantly complexed to GTP in vivo.	Guanosine Triphosphate	137-140	ras homolog family member A	Bos taurus	14-17
2842690-2	1988	Oncogenic ras p21 variants result from amino acid substitutions at specific positions that cause p21 to occur predominantly complexed to GTP in vivo.	Guanosine Triphosphate	137-140	ras homolog family member A	Bos taurus	97-100
2842690-6	1988	Here, using pure GAP in a kinetic competition assay, we show that GAP interacts preferentially with the active GTP complexes of both normal and oncogenic Harvey (Ha) ras p21 compared with the inactive GDP complexes.	Guanosine Triphosphate	111-114	ras homolog family member A	Bos taurus	170-173
2842690-6	1988	Here, using pure GAP in a kinetic competition assay, we show that GAP interacts preferentially with the active GTP complexes of both normal and oncogenic Harvey (Ha) ras p21 compared with the inactive GDP complexes.	Guanosine Diphosphate	201-204	ras homolog family member A	Bos taurus	170-173
29408756-11	2018	In vitro, PGF2alpha was found to accelerate adhesion and migration by activating prostaglandin F receptor (FP receptor) and subsequent increasing RhoA activity in primary bovine retinal pericyte.	Dinoprost	10-19	ras homolog family member A	Bos taurus	146-150
26097378-10	2015	Y-27632 inhibited RhoA activation irrespective of whether the cells were isolated with trypsin or collagenase A.	Y 27632	0-7	ras homolog family member A	Bos taurus	18-22
25387906-4	2014	Further experiments revealed that HSS decreased RhoA activity, with a constitutively active RhoA mutant inhibiting while a negative RhoA mutant enhancing the HSS-induced Src polarity.	hepatic stimulator substance	34-37	ras homolog family member A	Bos taurus	92-96
25387906-4	2014	Further experiments revealed that HSS decreased RhoA activity, with a constitutively active RhoA mutant inhibiting while a negative RhoA mutant enhancing the HSS-induced Src polarity.	hepatic stimulator substance	34-37	ras homolog family member A	Bos taurus	92-96
25387906-4	2014	Further experiments revealed that HSS decreased RhoA activity, with a constitutively active RhoA mutant inhibiting while a negative RhoA mutant enhancing the HSS-induced Src polarity.	hepatic stimulator substance	158-161	ras homolog family member A	Bos taurus	48-52
25387906-7	2014	The inhibition of Src by PP1, as well as the perturbation of RhoA activity and membrane fluidity, can block this HSS-induced FAK polarity.	hepatic stimulator substance	113-116	ras homolog family member A	Bos taurus	61-65
25387906-8	2014	These results indicate that the HSS-induced Src and subsequently FAK polarity depends on the coordination between intracellular tension distribution regulated by RhoA, its related actin structures and the plasma membrane fluidity.	hepatic stimulator substance	32-35	ras homolog family member A	Bos taurus	162-166
24320935-7	2014	Sulfated alginate increased the RhoA activity of chondrocytes compared with unmodified alginate, an increase that was blocked by beta1 blocking antibodies (p=0.017).	Alginates	9-17	ras homolog family member A	Bos taurus	32-36
21740411-12	2012	CONCLUSIONS AND IMPLICATIONS: Our data indicate that the oxidative species ONOO(-) and H(2) O(2) increase arginase activity/expression through PKC-mediated activation of RhoA/Rho kinase pathway.	onoo(	75-80	ras homolog family member A	Bos taurus	170-174
21740411-12	2012	CONCLUSIONS AND IMPLICATIONS: Our data indicate that the oxidative species ONOO(-) and H(2) O(2) increase arginase activity/expression through PKC-mediated activation of RhoA/Rho kinase pathway.	Hydrogen Peroxide	87-96	ras homolog family member A	Bos taurus	170-174
22860057-4	2012	In this study we investigated the involvement of RhoA activation in the inhibition of hemichannel-mediated ATP release in BCEC.	hemichannel	86-97	ras homolog family member A	Bos taurus	49-53
22860057-4	2012	In this study we investigated the involvement of RhoA activation in the inhibition of hemichannel-mediated ATP release in BCEC.	Adenosine Triphosphate	107-110	ras homolog family member A	Bos taurus	49-53
22860057-9	2012	This study demonstrates that RhoA GTPase activity is involved in the acute inhibition of ATP-dependent paracrine signaling, mediated by Cx43 hemichannels, in response to the inflammatory mediator thrombin.	Adenosine Triphosphate	89-92	ras homolog family member A	Bos taurus	29-33
22860057-10	2012	Therefore, RhoA appears to be an important molecular switch that controls Cx43 hemichannel openings and hemichannel-mediated ATP-dependent paracrine intercellular communication under (patho)physiological conditions of stress.	hemichannel	79-90	ras homolog family member A	Bos taurus	11-15
22860057-10	2012	Therefore, RhoA appears to be an important molecular switch that controls Cx43 hemichannel openings and hemichannel-mediated ATP-dependent paracrine intercellular communication under (patho)physiological conditions of stress.	Adenosine Triphosphate	125-128	ras homolog family member A	Bos taurus	11-15