PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 1166483-2 1975 The plasma concentration of estradiol-17beta (PCE2) was increased in men with hyperthyroidism. Estradiol 28-44 carboxylesterase 2 Homo sapiens 46-50 2686525-3 1989 The antihypertensive efficacy or perindopril, an ICE active in one single daily dose, is at least equal to that of reference antihypertensive drugs administered at usual doses. Perindopril 33-44 carboxylesterase 2 Homo sapiens 49-52 2686525-4 1989 The possibility of occurrence of some side-effects while using ICE, has resulted in a particular attention in evaluating the safety of perindopril. Perindopril 135-146 carboxylesterase 2 Homo sapiens 63-66 3370116-1 1988 Ice water immersion as a form of self care. Water 4-9 carboxylesterase 2 Homo sapiens 0-3 3027169-1 1987 The capacity of prostaglandin E2 (PCE2) to modulate human peripheral blood B cell proliferation and the generation of immunoglobulin-secreting cells (ISC) stimulated by Cowan 1 strain Staphylococcus aureus and mitogen-stimulated T cell supernatant was examined. Dinoprostone 16-32 carboxylesterase 2 Homo sapiens 34-38 2877675-2 1986 Soluble and insoluble PG-LDL complexes increased the incorporation of [3H]oleate into cellular cholesteryl esters (CE) 1.6- and 2.8-fold, respectively, while LDL incubated with collagen and lysyl oxidase had no effect compared to control LDL. 3h]oleate 71-80 carboxylesterase 2 Homo sapiens 95-129 7068434-0 1982 Hemoglobin Kawachi [alpha 44 (CE2) Pro leads to Arg]: a new hemoglobin variant of high oxygen affinity with amino acid substitution at alpha 1 beta 2 contact. Proline 35-38 carboxylesterase 2 Homo sapiens 30-33 7068434-0 1982 Hemoglobin Kawachi [alpha 44 (CE2) Pro leads to Arg]: a new hemoglobin variant of high oxygen affinity with amino acid substitution at alpha 1 beta 2 contact. Arginine 48-51 carboxylesterase 2 Homo sapiens 30-33 7068434-0 1982 Hemoglobin Kawachi [alpha 44 (CE2) Pro leads to Arg]: a new hemoglobin variant of high oxygen affinity with amino acid substitution at alpha 1 beta 2 contact. Oxygen 87-93 carboxylesterase 2 Homo sapiens 30-33 7003088-1 1980 Two hundred and sixty-one patients of varying parity and cervical "ripeness" were given Prostaglandin E2 (PCE2) in tylose gel either vaginally (2.0 mgm) or extraamniotically (0.3 mgm) prior to planned surgical induction. Dinoprostone 88-104 carboxylesterase 2 Homo sapiens 106-110 7003088-1 1980 Two hundred and sixty-one patients of varying parity and cervical "ripeness" were given Prostaglandin E2 (PCE2) in tylose gel either vaginally (2.0 mgm) or extraamniotically (0.3 mgm) prior to planned surgical induction. methylethylcellulose 115-121 carboxylesterase 2 Homo sapiens 106-110 6033707-2 1967 Ice as a possible model for biological structured-water systems. Water 50-55 carboxylesterase 2 Homo sapiens 0-3 17839615-0 1967 Metastable Superheated Ice in Liquid-Water Inclusions under High Negative Pressure. Water 37-42 carboxylesterase 2 Homo sapiens 23-26 17769917-1 1965 The activation energies of ice with varying amounts of impurities added were investigated with sintered platinum electrodes. Platinum 104-112 carboxylesterase 2 Homo sapiens 27-30 33722734-8 2021 Flutamide was hydrolyzed by monkey CES2, not by AADAC. Flutamide 0-9 carboxylesterase 2 Homo sapiens 35-39 17753950-1 1962 The improved system here described has been used successfully in systematic measurements of direct-current conductivity of ice doped with hydrofluoric and hydrochloric acids. hydrofluoric and hydrochloric acids 138-173 carboxylesterase 2 Homo sapiens 123-126 17787489-0 1946 The Production of Ice Crystals in a Cloud of Supercooled Water Droplets. Water 57-62 carboxylesterase 2 Homo sapiens 18-21 33872946-3 2021 For 26 kinds of synthesized indomethacin prodrugs, the hydrolytic rate was measured in the presence of human liver microsomes (HLM), human small intestine microsomes (HIM), hCE1 and hCE2. Indomethacin 28-40 carboxylesterase 2 Homo sapiens 182-186 17743969-0 1965 Fast Reactions of Ascorbic Acid and Hydrogen Peroxide in Ice, a Presumptive Early Environment. Ascorbic Acid 18-31 carboxylesterase 2 Homo sapiens 57-60 17743969-0 1965 Fast Reactions of Ascorbic Acid and Hydrogen Peroxide in Ice, a Presumptive Early Environment. Hydrogen Peroxide 36-53 carboxylesterase 2 Homo sapiens 57-60 17743969-1 1965 Nonenzymatic decomposition of hydrogen peroxide proceeded more rapidly in ice than in liquid water. Hydrogen Peroxide 30-47 carboxylesterase 2 Homo sapiens 74-77 17743969-2 1965 At 5 x 10(-7)M ferric chloride or 10(-8)M cupric chloride, breakdown of hiydrogen peroxide was significant at -11 degrees and -18 degrees but negligible at +1 degrees C. Ascorbic acid oxidation was faster in ice both with or without added metalion. ferric chloride 15-30 carboxylesterase 2 Homo sapiens 208-211 17743969-2 1965 At 5 x 10(-7)M ferric chloride or 10(-8)M cupric chloride, breakdown of hiydrogen peroxide was significant at -11 degrees and -18 degrees but negligible at +1 degrees C. Ascorbic acid oxidation was faster in ice both with or without added metalion. cupric chloride 42-57 carboxylesterase 2 Homo sapiens 208-211 17743969-2 1965 At 5 x 10(-7)M ferric chloride or 10(-8)M cupric chloride, breakdown of hiydrogen peroxide was significant at -11 degrees and -18 degrees but negligible at +1 degrees C. Ascorbic acid oxidation was faster in ice both with or without added metalion. hiydrogen peroxide 72-90 carboxylesterase 2 Homo sapiens 208-211 17743969-2 1965 At 5 x 10(-7)M ferric chloride or 10(-8)M cupric chloride, breakdown of hiydrogen peroxide was significant at -11 degrees and -18 degrees but negligible at +1 degrees C. Ascorbic acid oxidation was faster in ice both with or without added metalion. Ascorbic Acid 170-183 carboxylesterase 2 Homo sapiens 208-211 33872946-6 2021 hCE2 was susceptible to electron density of the substrate, and there was a difference in the hydrolysis rate of up to 3.5-times between p-bromophenyl ester and p-acetylphenyl ester. p-bromophenyl ester 136-155 carboxylesterase 2 Homo sapiens 0-4 33872946-6 2021 hCE2 was susceptible to electron density of the substrate, and there was a difference in the hydrolysis rate of up to 3.5-times between p-bromophenyl ester and p-acetylphenyl ester. p-acetylphenyl ester 160-180 carboxylesterase 2 Homo sapiens 0-4 33369768-0 2021 Remdesivir potently inhibits carboxylesterase-2 through covalent modifications: signifying strong drug-drug interactions. remdesivir 0-10 carboxylesterase 2 Homo sapiens 29-47 33741472-6 2021 In liver, where carboxylesterase 1 (CES1) is the predominant esterase enzyme, the shorter chain parabens were more readily metabolized, while in skin, where carboxylesterase 2 (CES2) is the predominant esterase enzyme, the longer chain parabens were more readily metabolized. Parabens 96-104 carboxylesterase 2 Homo sapiens 157-175 33741472-6 2021 In liver, where carboxylesterase 1 (CES1) is the predominant esterase enzyme, the shorter chain parabens were more readily metabolized, while in skin, where carboxylesterase 2 (CES2) is the predominant esterase enzyme, the longer chain parabens were more readily metabolized. Parabens 96-104 carboxylesterase 2 Homo sapiens 177-181 33741472-6 2021 In liver, where carboxylesterase 1 (CES1) is the predominant esterase enzyme, the shorter chain parabens were more readily metabolized, while in skin, where carboxylesterase 2 (CES2) is the predominant esterase enzyme, the longer chain parabens were more readily metabolized. Parabens 236-244 carboxylesterase 2 Homo sapiens 177-181 33548613-8 2021 Moreover, owing to the photothermal effect of the Fe3O4 NPs, the coating"s surface temperature can be rapidly increased above 0 C under infrared irradiation, which facilitates the ice melting on cold surfaces. ferryl iron 50-55 carboxylesterase 2 Homo sapiens 181-184 33990323-1 2021 Ice-sheet responses to climate warming and associated sea-level rise depend sensitively on the form of the slip law that relates drag at the beds of glaciers to their slip velocity and basal water pressure. Water 191-196 carboxylesterase 2 Homo sapiens 0-3 33872605-5 2021 In this study, we examined activities of all Ces2 members towards TGs, diglycerides (DGs) and monoglycerides (MGs) as substrate. trichlorosucrose 66-69 carboxylesterase 2 Homo sapiens 45-49 33872605-5 2021 In this study, we examined activities of all Ces2 members towards TGs, diglycerides (DGs) and monoglycerides (MGs) as substrate. Diglycerides 71-83 carboxylesterase 2 Homo sapiens 45-49 33872605-5 2021 In this study, we examined activities of all Ces2 members towards TGs, diglycerides (DGs) and monoglycerides (MGs) as substrate. Diglycerides 85-88 carboxylesterase 2 Homo sapiens 45-49 33872605-5 2021 In this study, we examined activities of all Ces2 members towards TGs, diglycerides (DGs) and monoglycerides (MGs) as substrate. Monoglycerides 94-108 carboxylesterase 2 Homo sapiens 45-49 33872605-5 2021 In this study, we examined activities of all Ces2 members towards TGs, diglycerides (DGs) and monoglycerides (MGs) as substrate. Monoglycerides 110-113 carboxylesterase 2 Homo sapiens 45-49 33872605-7 2021 Notably, these Ces2 members and CES2 efficiently hydrolyzed DGs and MGs and their activities even surpassed those measured for TG hydrolysis. Monoglycerides 68-71 carboxylesterase 2 Homo sapiens 15-19 33872605-7 2021 Notably, these Ces2 members and CES2 efficiently hydrolyzed DGs and MGs and their activities even surpassed those measured for TG hydrolysis. Monoglycerides 68-71 carboxylesterase 2 Homo sapiens 32-36 34039987-2 2021 A well-known feature of its phase diagram is that high-temperature phases of ice with orientational disorder of the hydrogen-bonded water molecules undergo phase transitions to their ordered counterparts upon cooling. Hydrogen 116-124 carboxylesterase 2 Homo sapiens 77-80 34039987-2 2021 A well-known feature of its phase diagram is that high-temperature phases of ice with orientational disorder of the hydrogen-bonded water molecules undergo phase transitions to their ordered counterparts upon cooling. Water 132-137 carboxylesterase 2 Homo sapiens 77-80 34039987-4 2021 Instead, hydrochloric-acid-doped ice VI undergoes an alternative type of phase transition upon cooling at high pressure as the orientationally disordered ice remains disordered but undergoes structural distortions. Hydrochloric Acid 9-26 carboxylesterase 2 Homo sapiens 33-36 34039987-4 2021 Instead, hydrochloric-acid-doped ice VI undergoes an alternative type of phase transition upon cooling at high pressure as the orientationally disordered ice remains disordered but undergoes structural distortions. Hydrochloric Acid 9-26 carboxylesterase 2 Homo sapiens 154-157 33835819-0 2021 Phase Equilibrium of Water with Hexagonal and Cubic Ice Using the SCAN Functional. Water 21-26 carboxylesterase 2 Homo sapiens 52-55 33369768-3 2021 This study reports that remdesivir at nanomolar concentrations inhibits carboxylesterase-2 (CES2) through covalent modifications. remdesivir 24-34 carboxylesterase 2 Homo sapiens 72-90 33369768-3 2021 This study reports that remdesivir at nanomolar concentrations inhibits carboxylesterase-2 (CES2) through covalent modifications. remdesivir 24-34 carboxylesterase 2 Homo sapiens 92-96 33238050-0 2021 Water Mobility in the Interfacial Liquid Layer of Ice/Clay Nanocomposites. Water 0-5 carboxylesterase 2 Homo sapiens 50-53 33238050-1 2021 At solid/ice interfaces, a premelting layer is formed at temperatures below the melting point of bulk water. Water 102-107 carboxylesterase 2 Homo sapiens 9-12 33238050-3 2021 Herein, w e determined the translational diffusion coefficient D t of water in ice/clay nanocomposites serving as model systems for permafrost by quasi elastic neutron scattering. Water 71-76 carboxylesterase 2 Homo sapiens 80-83 33630990-1 2021 Carboxylesterase 2 (CES 2) is a key enzyme in the activation of the prodrug irinotecan (CPT-11) in the treatment against colorectal cancer and also has some relationship with the side effect of CPT-11 in clinical applications. Irinotecan 76-86 carboxylesterase 2 Homo sapiens 0-18 33630990-1 2021 Carboxylesterase 2 (CES 2) is a key enzyme in the activation of the prodrug irinotecan (CPT-11) in the treatment against colorectal cancer and also has some relationship with the side effect of CPT-11 in clinical applications. Irinotecan 76-86 carboxylesterase 2 Homo sapiens 20-25 33630990-1 2021 Carboxylesterase 2 (CES 2) is a key enzyme in the activation of the prodrug irinotecan (CPT-11) in the treatment against colorectal cancer and also has some relationship with the side effect of CPT-11 in clinical applications. Irinotecan 88-94 carboxylesterase 2 Homo sapiens 20-25 33630990-1 2021 Carboxylesterase 2 (CES 2) is a key enzyme in the activation of the prodrug irinotecan (CPT-11) in the treatment against colorectal cancer and also has some relationship with the side effect of CPT-11 in clinical applications. Irinotecan 88-94 carboxylesterase 2 Homo sapiens 0-18 33630990-1 2021 Carboxylesterase 2 (CES 2) is a key enzyme in the activation of the prodrug irinotecan (CPT-11) in the treatment against colorectal cancer and also has some relationship with the side effect of CPT-11 in clinical applications. Irinotecan 194-200 carboxylesterase 2 Homo sapiens 0-18 33568030-11 2021 CONCLUSION: Clotrimazole displayed a strong inhibitory effect against hCE2, which might be used as a potential combined agent co-administrated with CPT-11 to alleviate the hCE2-mediated severe side effects. Clotrimazole 12-24 carboxylesterase 2 Homo sapiens 70-74 33630990-1 2021 Carboxylesterase 2 (CES 2) is a key enzyme in the activation of the prodrug irinotecan (CPT-11) in the treatment against colorectal cancer and also has some relationship with the side effect of CPT-11 in clinical applications. Irinotecan 194-200 carboxylesterase 2 Homo sapiens 20-25 33630990-4 2021 These results fully demonstrated that DSAB is a promising molecular tool for the investigation of the biological functions of CES 2 in living systems and the discovery of novel CES 2 inhibitors for the treatment of CES 2 related physiological diseases. dimethyldioctadecylammonium 38-42 carboxylesterase 2 Homo sapiens 126-131 33630990-4 2021 These results fully demonstrated that DSAB is a promising molecular tool for the investigation of the biological functions of CES 2 in living systems and the discovery of novel CES 2 inhibitors for the treatment of CES 2 related physiological diseases. dimethyldioctadecylammonium 38-42 carboxylesterase 2 Homo sapiens 177-182 33630990-4 2021 These results fully demonstrated that DSAB is a promising molecular tool for the investigation of the biological functions of CES 2 in living systems and the discovery of novel CES 2 inhibitors for the treatment of CES 2 related physiological diseases. dimethyldioctadecylammonium 38-42 carboxylesterase 2 Homo sapiens 177-182 33568030-4 2021 OBJECTIVE: The objective of this study was to investigate and compare the inhibition behaviors of these two antifungal agents, ketoconazole and clotrimazole, on the human liver microsome hCE2 and to explore the underlying mechanism. Ketoconazole 127-139 carboxylesterase 2 Homo sapiens 187-191 33568030-11 2021 CONCLUSION: Clotrimazole displayed a strong inhibitory effect against hCE2, which might be used as a potential combined agent co-administrated with CPT-11 to alleviate the hCE2-mediated severe side effects. Clotrimazole 12-24 carboxylesterase 2 Homo sapiens 172-176 33568030-11 2021 CONCLUSION: Clotrimazole displayed a strong inhibitory effect against hCE2, which might be used as a potential combined agent co-administrated with CPT-11 to alleviate the hCE2-mediated severe side effects. Irinotecan 148-154 carboxylesterase 2 Homo sapiens 70-74 33568030-4 2021 OBJECTIVE: The objective of this study was to investigate and compare the inhibition behaviors of these two antifungal agents, ketoconazole and clotrimazole, on the human liver microsome hCE2 and to explore the underlying mechanism. Clotrimazole 144-156 carboxylesterase 2 Homo sapiens 187-191 33568030-6 2021 RESULTS: Clotrimazole significantly inhibited the hCE2 activity, which was manifested by attenuated fluorescence when the substrates were FD and NCEN. Clotrimazole 9-21 carboxylesterase 2 Homo sapiens 50-54 33568030-11 2021 CONCLUSION: Clotrimazole displayed a strong inhibitory effect against hCE2, which might be used as a potential combined agent co-administrated with CPT-11 to alleviate the hCE2-mediated severe side effects. Irinotecan 148-154 carboxylesterase 2 Homo sapiens 172-176 33421954-7 2021 The 8alpha,30alpha-epoxy moiety of mexicanolide and the Delta8,14 double bond of phragmalin are pivotal for agonistic effects of these limonoids on hPXR, whereas the 6-OAc group of mexicanolide is crucial for its inhibitory activity against hCES2. mexicanolide 35-47 carboxylesterase 2 Homo sapiens 241-246 33568030-7 2021 The inhibitory effect of clotrimazole towards hCE2 was much stronger than that of ketoconazole, and the inhibitory behaviors displayed substrate-dependent inhibition. Clotrimazole 25-37 carboxylesterase 2 Homo sapiens 46-50 33568030-9 2021 Furthermore, the inhibitions of clotrimazole towards hCE2-mediated hydrolysis of FD, NCEN and CPT-11 were all in competitive mode with the Ki values of 0.483 muM, 8.63 muM and 29.0 muM, respectively. Clotrimazole 32-44 carboxylesterase 2 Homo sapiens 53-57 33568030-9 2021 Furthermore, the inhibitions of clotrimazole towards hCE2-mediated hydrolysis of FD, NCEN and CPT-11 were all in competitive mode with the Ki values of 0.483 muM, 8.63 muM and 29.0 muM, respectively. ncen 85-89 carboxylesterase 2 Homo sapiens 53-57 33568030-9 2021 Furthermore, the inhibitions of clotrimazole towards hCE2-mediated hydrolysis of FD, NCEN and CPT-11 were all in competitive mode with the Ki values of 0.483 muM, 8.63 muM and 29.0 muM, respectively. Irinotecan 94-100 carboxylesterase 2 Homo sapiens 53-57 33568030-10 2021 Molecular docking result of clotrimazole binding to hCE2 illustrated that clotrimazole could efficiently orient itself in the Z site cavity of hCE2. Clotrimazole 28-40 carboxylesterase 2 Homo sapiens 52-56 33568030-10 2021 Molecular docking result of clotrimazole binding to hCE2 illustrated that clotrimazole could efficiently orient itself in the Z site cavity of hCE2. Clotrimazole 28-40 carboxylesterase 2 Homo sapiens 143-147 33568030-10 2021 Molecular docking result of clotrimazole binding to hCE2 illustrated that clotrimazole could efficiently orient itself in the Z site cavity of hCE2. Clotrimazole 74-86 carboxylesterase 2 Homo sapiens 52-56 33568030-10 2021 Molecular docking result of clotrimazole binding to hCE2 illustrated that clotrimazole could efficiently orient itself in the Z site cavity of hCE2. Clotrimazole 74-86 carboxylesterase 2 Homo sapiens 143-147 33421954-0 2021 Discovery of Thai mangrove tetranortriterpenoids as agonists of human pregnane-X-receptor and inhibitors against human carboxylesterase 2. thai mangrove tetranortriterpenoids 13-48 carboxylesterase 2 Homo sapiens 119-137 33421954-3 2021 Potent and selective inhibitors of human carboxylesterase 2 (hCES2) could be utilized to alleviate the toxicity induced by ester drugs. Esters 49-54 carboxylesterase 2 Homo sapiens 61-66 33421954-7 2021 The 8alpha,30alpha-epoxy moiety of mexicanolide and the Delta8,14 double bond of phragmalin are pivotal for agonistic effects of these limonoids on hPXR, whereas the 6-OAc group of mexicanolide is crucial for its inhibitory activity against hCES2. Limonins 135-144 carboxylesterase 2 Homo sapiens 241-246 33421954-8 2021 Additionally, the flexible C-17-side-chain with appropriate hydroxy groups is considered to be important for the inhibitory activity of apotirucallane against hCES2. Carbon 27-28 carboxylesterase 2 Homo sapiens 159-164 33421954-8 2021 Additionally, the flexible C-17-side-chain with appropriate hydroxy groups is considered to be important for the inhibitory activity of apotirucallane against hCES2. apotirucallane 136-150 carboxylesterase 2 Homo sapiens 159-164 33007602-1 2021 Human carboxylesterase 2 (hCES2A), one of the major serine hydrolases distributed in the small intestine, plays a crucial role in hydrolysis of ester-bearing drugs. Serine 52-58 carboxylesterase 2 Homo sapiens 6-24 33645031-3 2021 Using the pharmacophore model established, 5 potential hCE2 inhibitors(CS-1,CS-2,CS-3,CS-6 and CS-8) were screened from 20 compounds isolated from the roots of Paeonia lactiflora, which were further confirmed in vitro, with the IC_(50) values of 5.04, 5.21, 5.95, 6.64 and 7.94 mumol L~(-1), respectively. Cesium 71-73 carboxylesterase 2 Homo sapiens 55-59 33645031-3 2021 Using the pharmacophore model established, 5 potential hCE2 inhibitors(CS-1,CS-2,CS-3,CS-6 and CS-8) were screened from 20 compounds isolated from the roots of Paeonia lactiflora, which were further confirmed in vitro, with the IC_(50) values of 5.04, 5.21, 5.95, 6.64 and 7.94 mumol L~(-1), respectively. Cesium 76-78 carboxylesterase 2 Homo sapiens 55-59 33645031-3 2021 Using the pharmacophore model established, 5 potential hCE2 inhibitors(CS-1,CS-2,CS-3,CS-6 and CS-8) were screened from 20 compounds isolated from the roots of Paeonia lactiflora, which were further confirmed in vitro, with the IC_(50) values of 5.04, 5.21, 5.95, 6.64 and 7.94 mumol L~(-1), respectively. Cesium 76-78 carboxylesterase 2 Homo sapiens 55-59 33645031-3 2021 Using the pharmacophore model established, 5 potential hCE2 inhibitors(CS-1,CS-2,CS-3,CS-6 and CS-8) were screened from 20 compounds isolated from the roots of Paeonia lactiflora, which were further confirmed in vitro, with the IC_(50) values of 5.04, 5.21, 5.95, 6.64 and 7.94 mumol L~(-1), respectively. Cesium 76-78 carboxylesterase 2 Homo sapiens 55-59 33645031-3 2021 Using the pharmacophore model established, 5 potential hCE2 inhibitors(CS-1,CS-2,CS-3,CS-6 and CS-8) were screened from 20 compounds isolated from the roots of Paeonia lactiflora, which were further confirmed in vitro, with the IC_(50) values of 5.04, 5.21, 5.95, 6.64 and 7.94 mumol L~(-1), respectively. Cesium 76-78 carboxylesterase 2 Homo sapiens 55-59 33189757-0 2021 Investigation of the inhibitory effect of protostanes on human carboxylesterase 2 and their interaction: Inhibition kinetics and molecular stimulations. protostanes 42-53 carboxylesterase 2 Homo sapiens 63-81 33189757-3 2021 Despite the extensive studies of pharmacological activities, the investigation on inhibitory effects of protostanes against CES 2 is rarely reported. protostanes 104-115 carboxylesterase 2 Homo sapiens 124-129 33189757-4 2021 In this study, the inhibitory activities of a library of protostanes (1-25) against human CES 2 were investigated for the first time, using 6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate (DDAB) as the specific fluorescent probe for human CES 2. protostanes 57-68 carboxylesterase 2 Homo sapiens 90-95 33189757-4 2021 In this study, the inhibitory activities of a library of protostanes (1-25) against human CES 2 were investigated for the first time, using 6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate (DDAB) as the specific fluorescent probe for human CES 2. protostanes 57-68 carboxylesterase 2 Homo sapiens 256-261 33189757-6 2021 For the most potent compounds 1, 7, 13, and 25, the inhibition kinetics were further investigated, and these four protostanes were all uncompetitive inhibitors against human CES 2 with the inhibition constants (Ki) values ranging from 0.89 muM to 2.83 muM. protostanes 114-125 carboxylesterase 2 Homo sapiens 174-179 33189757-7 2021 In addition, molecular docking and molecular dynamics stimulation were employed to analyze the potential interactions between these protostanes and CES 2, and amino acid residue Gln422 was identified to have played a crucial role in the strong inhibition of protostanes towards CES 2. protostanes 132-143 carboxylesterase 2 Homo sapiens 148-153 33189757-7 2021 In addition, molecular docking and molecular dynamics stimulation were employed to analyze the potential interactions between these protostanes and CES 2, and amino acid residue Gln422 was identified to have played a crucial role in the strong inhibition of protostanes towards CES 2. protostanes 132-143 carboxylesterase 2 Homo sapiens 278-283 33480790-3 2021 By means of the seeding technique we estimate the size of the ice critical nucleus N_{c} for the TIP4P/Ice water model. Water 107-112 carboxylesterase 2 Homo sapiens 62-65 33291124-1 2021 Human carboxylesterase 2 (hCES2A) is a key target to ameliorate the intestinal toxicity triggered by irinotecan that causes severe diarrhea in 50%-80% of patients receiving this anticancer agent. Irinotecan 101-111 carboxylesterase 2 Homo sapiens 6-24 33325808-6 2021 Mechanistically, human CES2 reduced hepatic triglyceride (T) and free fatty acid (FFA) levels by inducing lipolysis and fatty acid oxidation and inhibiting lipogenesis via suppression of sterol regulatory element-binding protein 1. Triglycerides 44-56 carboxylesterase 2 Homo sapiens 23-27 33325808-6 2021 Mechanistically, human CES2 reduced hepatic triglyceride (T) and free fatty acid (FFA) levels by inducing lipolysis and fatty acid oxidation and inhibiting lipogenesis via suppression of sterol regulatory element-binding protein 1. Fatty Acids, Nonesterified 65-80 carboxylesterase 2 Homo sapiens 23-27 33325808-6 2021 Mechanistically, human CES2 reduced hepatic triglyceride (T) and free fatty acid (FFA) levels by inducing lipolysis and fatty acid oxidation and inhibiting lipogenesis via suppression of sterol regulatory element-binding protein 1. Fatty Acids, Nonesterified 82-85 carboxylesterase 2 Homo sapiens 23-27 33325808-6 2021 Mechanistically, human CES2 reduced hepatic triglyceride (T) and free fatty acid (FFA) levels by inducing lipolysis and fatty acid oxidation and inhibiting lipogenesis via suppression of sterol regulatory element-binding protein 1. Fatty Acids 70-80 carboxylesterase 2 Homo sapiens 23-27 33325808-9 2021 Targeting hepatic CES2 may be an attractive strategy for treatment of NAFLD.NEW & NOTEWORTHY Human CES2 attenuates high-fat/cholesterol/fructose diet-induced steatohepatitis and reverses steatohepatitis in db/db mice. Cholesterol 124-135 carboxylesterase 2 Homo sapiens 18-22 33325808-9 2021 Targeting hepatic CES2 may be an attractive strategy for treatment of NAFLD.NEW & NOTEWORTHY Human CES2 attenuates high-fat/cholesterol/fructose diet-induced steatohepatitis and reverses steatohepatitis in db/db mice. Cholesterol 124-135 carboxylesterase 2 Homo sapiens 99-103 33325808-9 2021 Targeting hepatic CES2 may be an attractive strategy for treatment of NAFLD.NEW & NOTEWORTHY Human CES2 attenuates high-fat/cholesterol/fructose diet-induced steatohepatitis and reverses steatohepatitis in db/db mice. Fructose 136-144 carboxylesterase 2 Homo sapiens 18-22 33325808-9 2021 Targeting hepatic CES2 may be an attractive strategy for treatment of NAFLD.NEW & NOTEWORTHY Human CES2 attenuates high-fat/cholesterol/fructose diet-induced steatohepatitis and reverses steatohepatitis in db/db mice. Fructose 136-144 carboxylesterase 2 Homo sapiens 99-103 33325808-10 2021 Mechanistically, human CES2 induces lipolysis, fatty acid and glucose oxidation, and inhibits hepatic glucose production, inflammation, lipid oxidation, and apoptosis. Fatty Acids 47-57 carboxylesterase 2 Homo sapiens 23-27 33325808-10 2021 Mechanistically, human CES2 induces lipolysis, fatty acid and glucose oxidation, and inhibits hepatic glucose production, inflammation, lipid oxidation, and apoptosis. Glucose 62-69 carboxylesterase 2 Homo sapiens 23-27 33241686-7 2020 This application was particularly suited for an SRR due to the extreme difference between the relative permittivity of water (epsilon = 90) and ice (epsilon = 3.2) at 5 GHz and 0 C. The results from this sensor can be used to determine the holdover time of various coatings to resist ice formation. Water 119-124 carboxylesterase 2 Homo sapiens 285-288 33044079-0 2020 Atomic Steps Induce the Aligned Growth of Ice Crystals on Graphite Surfaces. Graphite 58-66 carboxylesterase 2 Homo sapiens 42-45 32736114-6 2020 Lineweaver-Burk plots showed that 2"-OH-PCB61 and 2"-OH-PCB65 exerted non-competitive inhibition towards CES1 and competitive inhibition towards CES2. 2"-oh-pcb61 34-45 carboxylesterase 2 Homo sapiens 145-149 32736114-6 2020 Lineweaver-Burk plots showed that 2"-OH-PCB61 and 2"-OH-PCB65 exerted non-competitive inhibition towards CES1 and competitive inhibition towards CES2. 2"-oh-pcb65 50-61 carboxylesterase 2 Homo sapiens 145-149 32736114-8 2020 The inhibition kinetics parameters (Ki) were 1.4 muM and 1.0 muM for 2"-OH-PCB61 and 2"-OH-PCB65 towards CES2, respectively. 2"-oh-pcb61 69-80 carboxylesterase 2 Homo sapiens 105-109 32736114-8 2020 The inhibition kinetics parameters (Ki) were 1.4 muM and 1.0 muM for 2"-OH-PCB61 and 2"-OH-PCB65 towards CES2, respectively. 2"-oh-pcb65 85-96 carboxylesterase 2 Homo sapiens 105-109 32736114-9 2020 In silico docking methods elucidate the contribution of hydrogen bonds and hydrophobic contacts towards the binding of 2"-OH-PCB61 and 2"-OH-PCB65 with CES1 and CES2. Hydrogen 56-64 carboxylesterase 2 Homo sapiens 161-165 32736114-9 2020 In silico docking methods elucidate the contribution of hydrogen bonds and hydrophobic contacts towards the binding of 2"-OH-PCB61 and 2"-OH-PCB65 with CES1 and CES2. 2"-oh-pcb61 119-130 carboxylesterase 2 Homo sapiens 161-165 32736114-9 2020 In silico docking methods elucidate the contribution of hydrogen bonds and hydrophobic contacts towards the binding of 2"-OH-PCB61 and 2"-OH-PCB65 with CES1 and CES2. 2"-oh-pcb65 135-146 carboxylesterase 2 Homo sapiens 161-165 33424602-2 2020 Studies aim at identifying genetic and non-genetic factors affecting vicagrel metabolic enzymes Cytochrome P450 2C19 (CYP2C19), Carboxylesterase (CES) 1 and 2 (CES1 and CES2), which may potentially lead to altered pharmacokinetics and pharmacodynamics, are warranted. methyl 2-(2-acetoxy-6,7-dihydrothieno(3,2-c)pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate 69-77 carboxylesterase 2 Homo sapiens 169-173 33424602-7 2020 Omeprazole, a CYP2C19 inhibitor, and simvastatin, a CES1 and CES2 inhibitor, showed weak impact on the pharmacokinetics and pharmacodynamics of vicagrel. Simvastatin 37-48 carboxylesterase 2 Homo sapiens 61-65 33424602-7 2020 Omeprazole, a CYP2C19 inhibitor, and simvastatin, a CES1 and CES2 inhibitor, showed weak impact on the pharmacokinetics and pharmacodynamics of vicagrel. methyl 2-(2-acetoxy-6,7-dihydrothieno(3,2-c)pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate 144-152 carboxylesterase 2 Homo sapiens 61-65 33080495-0 2020 Discovery of natural alkaloids as potent and selective inhibitors against human carboxylesterase 2. Alkaloids 21-30 carboxylesterase 2 Homo sapiens 80-98 32736114-2 2020 This study aims to determine the inhibition of OH-PCBs towards human carboxylesterases (CESs), including CES1 and CES2. oh-pcbs 47-54 carboxylesterase 2 Homo sapiens 114-118 32736114-3 2020 For phenotypic analysis of CES1 and CES2 activity, we used the hydrolysis metabolism of 2-(2-benzoyl3-methoxyphenyl) benzothiazole (BMBT) and fluorescein diacetate (FD) catalyzed by human liver microsomes (HLMs) as the probe reactions. 2-(2-benzoyl3-methoxyphenyl) benzothiazole 88-130 carboxylesterase 2 Homo sapiens 36-40 32736114-3 2020 For phenotypic analysis of CES1 and CES2 activity, we used the hydrolysis metabolism of 2-(2-benzoyl3-methoxyphenyl) benzothiazole (BMBT) and fluorescein diacetate (FD) catalyzed by human liver microsomes (HLMs) as the probe reactions. BMBT 132-136 carboxylesterase 2 Homo sapiens 36-40 32736114-3 2020 For phenotypic analysis of CES1 and CES2 activity, we used the hydrolysis metabolism of 2-(2-benzoyl3-methoxyphenyl) benzothiazole (BMBT) and fluorescein diacetate (FD) catalyzed by human liver microsomes (HLMs) as the probe reactions. diacetylfluorescein 142-163 carboxylesterase 2 Homo sapiens 36-40 32736114-4 2020 Preliminary inhibition screening showed that the inhibition potential of OH-PCBs towards CES1 and CES2 increased with the increased numbers of chlorine atoms in OH-PCBs. oh-pcbs 73-80 carboxylesterase 2 Homo sapiens 98-102 32736114-4 2020 Preliminary inhibition screening showed that the inhibition potential of OH-PCBs towards CES1 and CES2 increased with the increased numbers of chlorine atoms in OH-PCBs. Chlorine 143-151 carboxylesterase 2 Homo sapiens 98-102 32736114-4 2020 Preliminary inhibition screening showed that the inhibition potential of OH-PCBs towards CES1 and CES2 increased with the increased numbers of chlorine atoms in OH-PCBs. oh-pcbs 161-168 carboxylesterase 2 Homo sapiens 98-102 32736114-5 2020 Both 2"-OH-PCB61 and 2"-OH-PCB65 showed concentration-dependent inhibition towards both CES1 and CES2. 2"-oh-pcb61 5-16 carboxylesterase 2 Homo sapiens 97-101 32736114-5 2020 Both 2"-OH-PCB61 and 2"-OH-PCB65 showed concentration-dependent inhibition towards both CES1 and CES2. 2"-oh-pcb65 21-32 carboxylesterase 2 Homo sapiens 97-101 33312126-6 2020 CDD was rapidly metabolized into monoethylsuccinyl curcumin and curcumin in LS9 of all tested species mainly by carboxylesterases (CESs), including CES1 and CES2, and butyrylcholinesterase. curcumin diethyl disuccinate 0-3 carboxylesterase 2 Homo sapiens 157-161 32763559-0 2020 Fate and behaviour of weathered oil drifting into sea ice, using a novel wave and current flume. Oils 32-35 carboxylesterase 2 Homo sapiens 54-57 33121007-1 2020 CAP7.1 is a novel topoisomerase II inhibitor, converted to active etoposide via carboxylesterase 2 (CES2), with signals of efficacy in treatment-refractory solid tumours. Etoposide 66-75 carboxylesterase 2 Homo sapiens 80-98 33121007-1 2020 CAP7.1 is a novel topoisomerase II inhibitor, converted to active etoposide via carboxylesterase 2 (CES2), with signals of efficacy in treatment-refractory solid tumours. Etoposide 66-75 carboxylesterase 2 Homo sapiens 100-104 32505950-7 2020 However, these new adsorbed ammonia species, highly related to the sulfate from the Ce2(SO4)3, were inert and did not react with the adsorbed or gaseous NO species at 200-300 C. The abundant surface lattice oxygen from CeO2 microcrystals improved the catalytic oxidation capacity of the RMcn and RMcan. Ammonia 28-35 carboxylesterase 2 Homo sapiens 84-93 32505950-7 2020 However, these new adsorbed ammonia species, highly related to the sulfate from the Ce2(SO4)3, were inert and did not react with the adsorbed or gaseous NO species at 200-300 C. The abundant surface lattice oxygen from CeO2 microcrystals improved the catalytic oxidation capacity of the RMcn and RMcan. Sulfates 67-74 carboxylesterase 2 Homo sapiens 84-93 32505950-7 2020 However, these new adsorbed ammonia species, highly related to the sulfate from the Ce2(SO4)3, were inert and did not react with the adsorbed or gaseous NO species at 200-300 C. The abundant surface lattice oxygen from CeO2 microcrystals improved the catalytic oxidation capacity of the RMcn and RMcan. Oxygen 208-214 carboxylesterase 2 Homo sapiens 84-93 32945942-3 2020 The ICE (ifosfamide, cyclophosphamide, and etoposide) regimen is often used as salvage therapy for r/r DLBCL. Ifosfamide 9-19 carboxylesterase 2 Homo sapiens 4-7 32945942-3 2020 The ICE (ifosfamide, cyclophosphamide, and etoposide) regimen is often used as salvage therapy for r/r DLBCL. Cyclophosphamide 21-37 carboxylesterase 2 Homo sapiens 4-7 32945942-3 2020 The ICE (ifosfamide, cyclophosphamide, and etoposide) regimen is often used as salvage therapy for r/r DLBCL. Etoposide 43-52 carboxylesterase 2 Homo sapiens 4-7 32945942-4 2020 Several modified ICE regimens not requiring continuous ifosfamide infusion are available, which can be used in outpatient clinics. Ifosfamide 55-65 carboxylesterase 2 Homo sapiens 17-20 32945942-8 2020 Patients with low CCI scores (68%) had a higher ORR than those with high CCI scores (36.4%) upon f-R-ICE initiation (P = 0.042). Fluorine 97-99 carboxylesterase 2 Homo sapiens 101-104 32961616-2 2020 Here, we explore enhancement of the effect of irinotecan [camptothecin-11 (CPT-11)] by the p53-dependent induction of carboxylesterase 2 (CES2), a CPT-11-activating enzyme, in MM. Irinotecan 46-56 carboxylesterase 2 Homo sapiens 118-136 32961616-2 2020 Here, we explore enhancement of the effect of irinotecan [camptothecin-11 (CPT-11)] by the p53-dependent induction of carboxylesterase 2 (CES2), a CPT-11-activating enzyme, in MM. Irinotecan 46-56 carboxylesterase 2 Homo sapiens 138-142 32961616-2 2020 Here, we explore enhancement of the effect of irinotecan [camptothecin-11 (CPT-11)] by the p53-dependent induction of carboxylesterase 2 (CES2), a CPT-11-activating enzyme, in MM. Irinotecan 58-73 carboxylesterase 2 Homo sapiens 118-136 32961616-2 2020 Here, we explore enhancement of the effect of irinotecan [camptothecin-11 (CPT-11)] by the p53-dependent induction of carboxylesterase 2 (CES2), a CPT-11-activating enzyme, in MM. Irinotecan 58-73 carboxylesterase 2 Homo sapiens 138-142 32961616-2 2020 Here, we explore enhancement of the effect of irinotecan [camptothecin-11 (CPT-11)] by the p53-dependent induction of carboxylesterase 2 (CES2), a CPT-11-activating enzyme, in MM. Irinotecan 75-81 carboxylesterase 2 Homo sapiens 118-136 32961616-2 2020 Here, we explore enhancement of the effect of irinotecan [camptothecin-11 (CPT-11)] by the p53-dependent induction of carboxylesterase 2 (CES2), a CPT-11-activating enzyme, in MM. Irinotecan 75-81 carboxylesterase 2 Homo sapiens 138-142 32961616-2 2020 Here, we explore enhancement of the effect of irinotecan [camptothecin-11 (CPT-11)] by the p53-dependent induction of carboxylesterase 2 (CES2), a CPT-11-activating enzyme, in MM. Irinotecan 147-153 carboxylesterase 2 Homo sapiens 118-136 32961616-2 2020 Here, we explore enhancement of the effect of irinotecan [camptothecin-11 (CPT-11)] by the p53-dependent induction of carboxylesterase 2 (CES2), a CPT-11-activating enzyme, in MM. Irinotecan 147-153 carboxylesterase 2 Homo sapiens 138-142 32961616-5 2020 Knocking down CES2 in MM cells reduced the effect of the drug combination, and its forced expression in MESO4 cells enhanced the growth inhibitory activity of CPT-11 in the absence of nutlin-3a. Irinotecan 159-165 carboxylesterase 2 Homo sapiens 14-18 32470815-0 2020 Colorimetric detection of H2O2 based on the enhanced peroxidase mimetic activity of nanoparticles decorated Ce2(WO4)3 nanosheets. Hydrogen Peroxide 26-30 carboxylesterase 2 Homo sapiens 108-111 32470815-1 2020 In this paper, nanoparticles decorated Ce2(WO4)3 nanosheets (CWNSs) with negative potential and large specific surface area were synthesized and developed as highly efficient peroxidase mimics for colorimetric detection of H2O2. Hydrogen Peroxide 223-227 carboxylesterase 2 Homo sapiens 39-42 32763559-1 2020 Increased knowledge about the fate and behaviour of weathered oil in different sea ice conditions is essential for our ability to model oil spill trajectories in ice more precisely and for oil spill response decision making in northern and Arctic areas. Oils 62-65 carboxylesterase 2 Homo sapiens 83-86 32763559-1 2020 Increased knowledge about the fate and behaviour of weathered oil in different sea ice conditions is essential for our ability to model oil spill trajectories in ice more precisely and for oil spill response decision making in northern and Arctic areas. Oils 62-65 carboxylesterase 2 Homo sapiens 162-165 32763559-2 2020 As part of the 3-year project: "Fate, Behaviour and Response to Oil Drifting into Scattered Ice and Ice Edge in the Marginal Ice Zone", a novel wave and current flume was built to simulate these processes in the laboratory. Oils 64-67 carboxylesterase 2 Homo sapiens 92-95 32763559-5 2020 The build-up of oil drifting against an ice barrier and horizontal and vertical migration of oil droplets under solid ice and in frazil ice was studied. Oils 93-96 carboxylesterase 2 Homo sapiens 118-121 32763559-5 2020 The build-up of oil drifting against an ice barrier and horizontal and vertical migration of oil droplets under solid ice and in frazil ice was studied. Oils 93-96 carboxylesterase 2 Homo sapiens 118-121 32986308-0 2020 Spectroscopic Determination of Ice-Induced Interfacial Strain on Single-Layer Graphene. Graphite 78-86 carboxylesterase 2 Homo sapiens 31-34 32867537-4 2020 The in house database of NSAIDs-BZ prodrugs was first subjected to screening with our previously reported pharmacophore models of hCES1 (AAHRR.430) and hCES2 (AHHR.21) for determining hydrolytic susceptibility. 3-quinuclidinyl 4-fluoromethylbenzilate 32-34 carboxylesterase 2 Homo sapiens 152-157 32986308-2 2020 Here, non-destructive measurements of single-layer graphene (SLG) interfaced with bulk ice are used to determine temperature-dependent, ice-induced strain and estimate ice-created strain elastic density in SLG. Graphite 51-59 carboxylesterase 2 Homo sapiens 136-139 32986308-2 2020 Here, non-destructive measurements of single-layer graphene (SLG) interfaced with bulk ice are used to determine temperature-dependent, ice-induced strain and estimate ice-created strain elastic density in SLG. Graphite 51-59 carboxylesterase 2 Homo sapiens 136-139 32173137-0 2020 Corrigendum to "Flavonoids as human carboxylesterase 2 inhibitors: Inhibition potentials and molecular docking simulations" [Int. Flavonoids 16-26 carboxylesterase 2 Homo sapiens 36-54 33013487-0 2020 Efficient Cocaine Degradation by Cocaine Esterase-Loaded Red Blood Cells. Cocaine 10-17 carboxylesterase 2 Homo sapiens 33-49 33013487-1 2020 Recombinant bacterial cocaine esterase (CocE) represents a potential protein therapeutic for cocaine use disorder treatment. Cocaine 22-29 carboxylesterase 2 Homo sapiens 40-44 32629019-7 2020 It was also found that the 3,3-dimethylglutarate prodrug was selectively activated by hCES1 but not hCES2 or arylacetamidodeacetylase. 3,3-dimethylglutarate 27-48 carboxylesterase 2 Homo sapiens 100-105 32942370-2 2020 In some cases the melting point of ice may be shifted and one may find either ice, icelike water, or a state in which freezing is completely inhibited. Water 91-96 carboxylesterase 2 Homo sapiens 35-38 32574493-0 2020 Ice-like Vibrational Properties of Strong Hydrogen Bonds in Hydrated Lithium Nitrate. Hydrogen 42-50 carboxylesterase 2 Homo sapiens 0-3 32574493-0 2020 Ice-like Vibrational Properties of Strong Hydrogen Bonds in Hydrated Lithium Nitrate. Lithium nitrate 69-84 carboxylesterase 2 Homo sapiens 0-3 32574493-1 2020 The hydrogen bond network accounts for many of the extraordinary physical properties of liquid water and ice. Hydrogen 4-12 carboxylesterase 2 Homo sapiens 105-108 32574493-4 2020 In this study, we find striking resemblance between the vibrational properties of three water molecules connected via strong hydrogen bonds in the trihydrate of LiNO3 and those of ordinary ice Ih. Water 88-93 carboxylesterase 2 Homo sapiens 189-192 32574493-4 2020 In this study, we find striking resemblance between the vibrational properties of three water molecules connected via strong hydrogen bonds in the trihydrate of LiNO3 and those of ordinary ice Ih. Hydrogen 125-133 carboxylesterase 2 Homo sapiens 189-192 32574493-4 2020 In this study, we find striking resemblance between the vibrational properties of three water molecules connected via strong hydrogen bonds in the trihydrate of LiNO3 and those of ordinary ice Ih. trihydrate 147-157 carboxylesterase 2 Homo sapiens 189-192 32574493-4 2020 In this study, we find striking resemblance between the vibrational properties of three water molecules connected via strong hydrogen bonds in the trihydrate of LiNO3 and those of ordinary ice Ih. Lithium nitrate 161-166 carboxylesterase 2 Homo sapiens 189-192 32574493-5 2020 As in ice, the vibrations of the hydrate water molecules show ultrafast excited state dynamics that are strongly accelerated when proceeding from deuterated to neat H2O samples. Water 41-46 carboxylesterase 2 Homo sapiens 6-9 32574493-5 2020 As in ice, the vibrations of the hydrate water molecules show ultrafast excited state dynamics that are strongly accelerated when proceeding from deuterated to neat H2O samples. deuterated 146-156 carboxylesterase 2 Homo sapiens 6-9 32574493-5 2020 As in ice, the vibrations of the hydrate water molecules show ultrafast excited state dynamics that are strongly accelerated when proceeding from deuterated to neat H2O samples. Water 165-168 carboxylesterase 2 Homo sapiens 6-9 32414235-0 2020 Freezing of Aqueous Carboxylic Acid Solutions on Ice. Carboxylic Acids 20-35 carboxylesterase 2 Homo sapiens 49-52 32414235-1 2020 We study the properties of acetic acid and propionic acid solutions at the surface of monocrystalline ice with surface-specific vibrational sum-frequency generation (VSFG) and heterodyne-detected vibrational sum-frequency generation spectroscopy (HD-VSFG). Acetic Acid 27-38 carboxylesterase 2 Homo sapiens 102-105 32414235-1 2020 We study the properties of acetic acid and propionic acid solutions at the surface of monocrystalline ice with surface-specific vibrational sum-frequency generation (VSFG) and heterodyne-detected vibrational sum-frequency generation spectroscopy (HD-VSFG). propionic acid 43-57 carboxylesterase 2 Homo sapiens 102-105 32546729-0 2020 Heterogeneous Ice Nucleation by Graphene Nanoparticles. Graphite 32-40 carboxylesterase 2 Homo sapiens 14-17 32441526-8 2020 A thick blanket of C60 on top of pure amorphous ice is found to display large cracks due to water desorption. Water 92-97 carboxylesterase 2 Homo sapiens 48-51 31983007-1 2020 Preparation of Ce2(MoO4)3 nanoparticles is reported via the microemulsion method by using two different surfactants, i.e., cationic surfactant, cetyltrimethylammonium bromide (CTAB), and nonionic surfactant, Triton X-100. hexadecyl trimethyl ammonium bromide 144-174 carboxylesterase 2 Homo sapiens 15-18 32138548-4 2020 Dissolved selenate was separated from dissolved selenite, carbonate, phosphate, and arsenate by addition of Ce3+ cations that quantitatively removed these oxyanions by precipitation as insoluble Ce2(SeO3)3(s), Ce2(CO3)3(s), CePO4(s), and CeAsO4(s), respectively. Selenic Acid 10-18 carboxylesterase 2 Homo sapiens 195-198 32138548-4 2020 Dissolved selenate was separated from dissolved selenite, carbonate, phosphate, and arsenate by addition of Ce3+ cations that quantitatively removed these oxyanions by precipitation as insoluble Ce2(SeO3)3(s), Ce2(CO3)3(s), CePO4(s), and CeAsO4(s), respectively. Selenic Acid 10-18 carboxylesterase 2 Homo sapiens 210-213 32138548-4 2020 Dissolved selenate was separated from dissolved selenite, carbonate, phosphate, and arsenate by addition of Ce3+ cations that quantitatively removed these oxyanions by precipitation as insoluble Ce2(SeO3)3(s), Ce2(CO3)3(s), CePO4(s), and CeAsO4(s), respectively. ce3+ 108-112 carboxylesterase 2 Homo sapiens 195-198 32138548-4 2020 Dissolved selenate was separated from dissolved selenite, carbonate, phosphate, and arsenate by addition of Ce3+ cations that quantitatively removed these oxyanions by precipitation as insoluble Ce2(SeO3)3(s), Ce2(CO3)3(s), CePO4(s), and CeAsO4(s), respectively. ce3+ 108-112 carboxylesterase 2 Homo sapiens 210-213 32138548-4 2020 Dissolved selenate was separated from dissolved selenite, carbonate, phosphate, and arsenate by addition of Ce3+ cations that quantitatively removed these oxyanions by precipitation as insoluble Ce2(SeO3)3(s), Ce2(CO3)3(s), CePO4(s), and CeAsO4(s), respectively. seo3)3 199-205 carboxylesterase 2 Homo sapiens 195-198 32393646-8 2020 Upon illumination under 1 sun, the surface temperature can increase by 53 C, so that no ice can form at an environmental temperature as low as -50 C and it can also rapidly melt the accumulated frost and ice in 300 s. The superhydrophobicity enables the melted water to slide away immediately, leaving a clean and dry surface. Water 263-268 carboxylesterase 2 Homo sapiens 206-209 32548466-0 2020 Enhancing the Freeze-Thaw Durability of Concrete through Ice Recrystallization Inhibition by Poly(vinyl alcohol). Polyvinyl Alcohol 93-112 carboxylesterase 2 Homo sapiens 57-60 32171111-8 2020 The ICE frequencies observed after G2/M abrogation by caffeine are similar to the ones without abrogation, and clearly lower to the ones observed in G2. Caffeine 54-62 carboxylesterase 2 Homo sapiens 4-7 32290444-3 2020 The sensor was intended to detect the high latent heat of fusion of water (334 J/g) which is released to the environment during ice formation. Water 68-73 carboxylesterase 2 Homo sapiens 128-131 32163660-1 2020 Freeze casting, also known as ice templating, is a particularly versatile technique that has been applied extensively for the fabrication of well-controlled biomimetic porous materials based on ceramics, metals, polymers, biomacromolecules, and carbon nanomaterials, endowing them with novel properties and broadening their applicability. Polymers 212-220 carboxylesterase 2 Homo sapiens 30-33 32163660-1 2020 Freeze casting, also known as ice templating, is a particularly versatile technique that has been applied extensively for the fabrication of well-controlled biomimetic porous materials based on ceramics, metals, polymers, biomacromolecules, and carbon nanomaterials, endowing them with novel properties and broadening their applicability. Carbon 245-251 carboxylesterase 2 Homo sapiens 30-33 32123952-1 2020 Human carboxylesterase 2 (hCE2), one of the most principal drug-metabolizing enzymes, catalyzes the hydrolysis of a variety of endogenous esters, anticancer agents, and environmental toxicants. Esters 138-144 carboxylesterase 2 Homo sapiens 6-24 32123952-1 2020 Human carboxylesterase 2 (hCE2), one of the most principal drug-metabolizing enzymes, catalyzes the hydrolysis of a variety of endogenous esters, anticancer agents, and environmental toxicants. Esters 138-144 carboxylesterase 2 Homo sapiens 26-30 32120078-0 2020 A novel 15-spiro diterpenoid dimer from Andrographis paniculata with inhibitory potential against human carboxylesterase 2. 15-spiro diterpenoid 8-28 carboxylesterase 2 Homo sapiens 104-122 31983007-1 2020 Preparation of Ce2(MoO4)3 nanoparticles is reported via the microemulsion method by using two different surfactants, i.e., cationic surfactant, cetyltrimethylammonium bromide (CTAB), and nonionic surfactant, Triton X-100. hexadecyl trimethyl ammonium bromide 176-180 carboxylesterase 2 Homo sapiens 15-18 31983007-1 2020 Preparation of Ce2(MoO4)3 nanoparticles is reported via the microemulsion method by using two different surfactants, i.e., cationic surfactant, cetyltrimethylammonium bromide (CTAB), and nonionic surfactant, Triton X-100. Polyethylene Glycols 208-214 carboxylesterase 2 Homo sapiens 15-18 31726091-6 2020 Hydrolase activities for irinotecan and procaine, which are CES2 substrates in humans, tended to be higher in RLM and MLM than in HLM. irinotecan 25-35 carboxylesterase 2 Homo sapiens 60-64 32006654-5 2020 Single cell gel electrophoresis assay and H2DCFDA analysis revealed that the expression of ALDH3A1 protected HCE-2 cells from H2O2-, tert-butyl peroxide- and etoposide-induced oxidative and genotoxic effects. Hydrogen Peroxide 126-152 carboxylesterase 2 Homo sapiens 109-114 32006654-5 2020 Single cell gel electrophoresis assay and H2DCFDA analysis revealed that the expression of ALDH3A1 protected HCE-2 cells from H2O2-, tert-butyl peroxide- and etoposide-induced oxidative and genotoxic effects. Etoposide 158-167 carboxylesterase 2 Homo sapiens 109-114 31836607-2 2020 In previous studies, we detected an unidentified esterase in the region of CES2 mobility on non-denaturing polyacrylamide gel electrophoresis (PAGE) analysis of monkey intestinal microsomes, which showed immunoreactivity for anti-mfCES2A antibody. polyacrylamide-hydrazide polymer 107-121 carboxylesterase 2 Homo sapiens 75-79 31981591-0 2020 Overexpressed CES2 has prognostic value in CRC and knockdown CES2 reverses L-OHP-resistance in CRC cells by inhibition of the PI3K signaling pathway. oxaliplatin 75-80 carboxylesterase 2 Homo sapiens 61-65 31981591-1 2020 CES-2 (carboxylesterase-2) belongs to the carboxylesterase gene family, which plays crucial roles in lipid mobilization and chemosensitivity to irinotecan. irinotecan 144-154 carboxylesterase 2 Homo sapiens 0-5 31981591-1 2020 CES-2 (carboxylesterase-2) belongs to the carboxylesterase gene family, which plays crucial roles in lipid mobilization and chemosensitivity to irinotecan. irinotecan 144-154 carboxylesterase 2 Homo sapiens 7-25 31981591-1 2020 CES-2 (carboxylesterase-2) belongs to the carboxylesterase gene family, which plays crucial roles in lipid mobilization and chemosensitivity to irinotecan. irinotecan 144-154 carboxylesterase 2 Homo sapiens 7-23 31981591-4 2020 The results showed that CES2 expression was upregulated in L-OHP-resistant tissues and cells lines (P < 0.01). oxaliplatin 59-64 carboxylesterase 2 Homo sapiens 24-28 31981591-6 2020 Downregulation of CES2 suppressed cell proliferation, induced apoptosis and reversed L-OHP resistance by medicating the PI3K signaling pathway in L-OHP-resistant cells. bis-valerato-oxalato-1,2-diaminocyclohexaneplatinum 87-90 carboxylesterase 2 Homo sapiens 18-22 31981591-6 2020 Downregulation of CES2 suppressed cell proliferation, induced apoptosis and reversed L-OHP resistance by medicating the PI3K signaling pathway in L-OHP-resistant cells. oxaliplatin 85-90 carboxylesterase 2 Homo sapiens 18-22 31981591-8 2020 These findings indicated that CES2 may be utilized as a novel biomarker and therapeutic target for L-OHP resistance in CRC treatment. oxaliplatin 99-104 carboxylesterase 2 Homo sapiens 30-34 30608492-5 2020 OBSERVATION: We have described a case of congenital orbital MRT, who presented with rapidly progressive right-sided proptosis and was initially treated with subtotal resection and postoperative chemotherapy with ICE (Ifosfamide, Carboplatin, Etoposide) regimen. Ifosfamide 217-227 carboxylesterase 2 Homo sapiens 212-215 31726091-6 2020 Hydrolase activities for irinotecan and procaine, which are CES2 substrates in humans, tended to be higher in RLM and MLM than in HLM. Procaine 40-48 carboxylesterase 2 Homo sapiens 60-64 30486721-6 2019 In vitro human liver microsomes (HLMs)-catalyzed hydrolysis of 2-(2-Benzoyl-3-methoxyphenyl) benzothiazole (BMBT) and fluorescein diacetate (FD) was employed as the probe reaction for CES1 and CES2, respectively. 2-(2-benzoyl-3-methoxyphenyl) benzothiazole 63-106 carboxylesterase 2 Homo sapiens 193-197 31279194-8 2019 Cerium removal was found to be related to the HCO3- concentration in solution, where Ce precipitated as Ce2(CO3)3 XH2O and as an amorphous carbonate phase. Cerium 0-6 carboxylesterase 2 Homo sapiens 104-107 31279194-8 2019 Cerium removal was found to be related to the HCO3- concentration in solution, where Ce precipitated as Ce2(CO3)3 XH2O and as an amorphous carbonate phase. Bicarbonates 46-50 carboxylesterase 2 Homo sapiens 104-107 32115554-1 2020 The first-pass hydrolysis of oral ester-type prodrugs in the liver and intestine is mediated mainly by hCE1 and hCE2 of the respective predominant carboxylesterase (CES) isozymes. Esters 34-39 carboxylesterase 2 Homo sapiens 112-116 32115554-3 2020 In the present study, we designed a prodrug of fexofenadine (FXD) as a model parent drug that is resistant to hCE2 but hydrolyzed by hCE1, utilizing the differences in catalytic characteristics of hCE1 and hCE2. fexofenadine 47-59 carboxylesterase 2 Homo sapiens 110-114 32115554-3 2020 In the present study, we designed a prodrug of fexofenadine (FXD) as a model parent drug that is resistant to hCE2 but hydrolyzed by hCE1, utilizing the differences in catalytic characteristics of hCE1 and hCE2. fexofenadine 47-59 carboxylesterase 2 Homo sapiens 206-210 31713417-3 2019 Herein, we report an ER targeting CES2 selective and sensitive ratiometric fluorescent probe ERNB based on the ER localizing group p-toluenesulfonamide. 2-toluenesulfonamide 133-151 carboxylesterase 2 Homo sapiens 34-38 31713417-6 2019 Additionally, using ERNB we evaluated CES2 regulation in DL-dithiothreitol (DTT) and tunicamycin-induced ER stress. Dithiothreitol 60-74 carboxylesterase 2 Homo sapiens 38-42 31713417-6 2019 Additionally, using ERNB we evaluated CES2 regulation in DL-dithiothreitol (DTT) and tunicamycin-induced ER stress. Tunicamycin 85-96 carboxylesterase 2 Homo sapiens 38-42 31713417-7 2019 Furthermore, we determined the down regulation of CES2 activity and expression in the APAP-induced acute liver injury model. Acetaminophen 86-90 carboxylesterase 2 Homo sapiens 50-54 30486721-6 2019 In vitro human liver microsomes (HLMs)-catalyzed hydrolysis of 2-(2-Benzoyl-3-methoxyphenyl) benzothiazole (BMBT) and fluorescein diacetate (FD) was employed as the probe reaction for CES1 and CES2, respectively. BMBT 108-112 carboxylesterase 2 Homo sapiens 193-197 30486721-6 2019 In vitro human liver microsomes (HLMs)-catalyzed hydrolysis of 2-(2-Benzoyl-3-methoxyphenyl) benzothiazole (BMBT) and fluorescein diacetate (FD) was employed as the probe reaction for CES1 and CES2, respectively. diacetylfluorescein 118-139 carboxylesterase 2 Homo sapiens 193-197 30486721-9 2019 Schisandrin B showed strong inhibition on the activity of CES1, and the activity of CES2 was strongly inhibited by Anwuligan and Schisandrin B. schizandrin B 129-142 carboxylesterase 2 Homo sapiens 84-88 30486721-10 2019 Schisandrin B exhibited noncompetitive inhibition towards CES1 and CES2. schizandrin B 0-13 carboxylesterase 2 Homo sapiens 67-71 30486721-12 2019 The inhibition kinetic parameters (Ki) were calculated to be 29.8, 0.6, and 8.1 uM for the inhibition of Schisandrin B on CES1, Anwuligan on CES2, and Schisandrin B on CES2. schizandrin B 151-164 carboxylesterase 2 Homo sapiens 168-172 30486721-13 2019 In silico docking showed that hydrogen bonds and hydrophobic interactions contributed to the inhibition of Schisandrin B on CES1, Anwuligan on CES2, and Schisandrin B on CES2. Hydrogen 30-38 carboxylesterase 2 Homo sapiens 143-147 30486721-13 2019 In silico docking showed that hydrogen bonds and hydrophobic interactions contributed to the inhibition of Schisandrin B on CES1, Anwuligan on CES2, and Schisandrin B on CES2. Hydrogen 30-38 carboxylesterase 2 Homo sapiens 170-174 30486721-13 2019 In silico docking showed that hydrogen bonds and hydrophobic interactions contributed to the inhibition of Schisandrin B on CES1, Anwuligan on CES2, and Schisandrin B on CES2. schizandrin B 153-166 carboxylesterase 2 Homo sapiens 170-174 31122751-9 2019 Despite second-line chemotherapy with R-ICE (rituximab-ifosfamide, carboplatin and etoposide), the patient died. rituximab-ifosfamide 45-65 carboxylesterase 2 Homo sapiens 40-43 31122751-9 2019 Despite second-line chemotherapy with R-ICE (rituximab-ifosfamide, carboplatin and etoposide), the patient died. Carboplatin 67-78 carboxylesterase 2 Homo sapiens 40-43 31122751-9 2019 Despite second-line chemotherapy with R-ICE (rituximab-ifosfamide, carboplatin and etoposide), the patient died. Etoposide 83-92 carboxylesterase 2 Homo sapiens 40-43 31513398-0 2019 Role of the Solvation Water in Remote Interactions of Hyperactive Antifreeze Proteins with the Surface of Ice. Water 22-27 carboxylesterase 2 Homo sapiens 106-109 31323527-6 2019 Some compounds were studied as inhibitors of the main human isozymes involved in biotransformation of ester-containing drugs, hCES1 and hCES2. Esters 102-107 carboxylesterase 2 Homo sapiens 136-141 31323527-7 2019 Esters of geraniol (3d) and adamantol (3e) proved to be highly active and selective inhibitors of hCES2, inhibiting the enzyme in the nanomolar range, whereas esters of borneol (3f) and isoborneol (3g) were more active and selective against hCES1. Esters 0-6 carboxylesterase 2 Homo sapiens 98-103 31323527-7 2019 Esters of geraniol (3d) and adamantol (3e) proved to be highly active and selective inhibitors of hCES2, inhibiting the enzyme in the nanomolar range, whereas esters of borneol (3f) and isoborneol (3g) were more active and selective against hCES1. geraniol 10-18 carboxylesterase 2 Homo sapiens 98-103 31323527-7 2019 Esters of geraniol (3d) and adamantol (3e) proved to be highly active and selective inhibitors of hCES2, inhibiting the enzyme in the nanomolar range, whereas esters of borneol (3f) and isoborneol (3g) were more active and selective against hCES1. adamantol 28-37 carboxylesterase 2 Homo sapiens 98-103 31323527-7 2019 Esters of geraniol (3d) and adamantol (3e) proved to be highly active and selective inhibitors of hCES2, inhibiting the enzyme in the nanomolar range, whereas esters of borneol (3f) and isoborneol (3g) were more active and selective against hCES1. isoborneol 186-196 carboxylesterase 2 Homo sapiens 98-103 31323527-10 2019 Overall, the results indicate that members of this novel series of esters have the potential to be good candidates as hCES1 or hCES2 inhibitors for biomedicinal applications. Esters 67-73 carboxylesterase 2 Homo sapiens 127-132 30848041-13 2019 DATA CONCLUSION: Breast tumor"s radiomic signatures from preoperative breast MRI sequences are associated with the ALN metastasis status, where CE2 phase and the contrast enhancement kinetic features lead to the highest classification effect. aln 115-118 carboxylesterase 2 Homo sapiens 144-147 31513398-4 2019 It acts at early stages of adsorption, prior to the solidification of water between the ice and the protein molecule nearby. Water 70-75 carboxylesterase 2 Homo sapiens 88-91 31513398-5 2019 We propose the water-originating mechanism of the generation of this force and also the mechanism of remote attachment of an antifreeze molecule to the ice surface. Water 15-20 carboxylesterase 2 Homo sapiens 152-155 31291611-0 2019 Demethylbellidifolin isolated from Swertia bimaculate against human carboxylesterase 2: Kinetics and interaction mechanism merged with docking simulations. demethylbellidifolin 0-20 carboxylesterase 2 Homo sapiens 68-86 31260759-1 2019 Human carboxylesterase 2 (CES2A), one of the most abundant hydrolases distributed in human small intestine and colon, play key roles in the hydrolysis of a wide range of prodrugs and other esters. Esters 189-195 carboxylesterase 2 Homo sapiens 6-24 31291611-4 2019 Demethylbellidifolin (1) was assayed for its inhibitory HCE 2 effect by HCE 2-mediated DDAB hydrolysis, and its potential IC50 value was 3.12 +- 0.64 muM. demethylbellidifolin 0-20 carboxylesterase 2 Homo sapiens 56-61 31291611-4 2019 Demethylbellidifolin (1) was assayed for its inhibitory HCE 2 effect by HCE 2-mediated DDAB hydrolysis, and its potential IC50 value was 3.12 +- 0.64 muM. demethylbellidifolin 0-20 carboxylesterase 2 Homo sapiens 72-77 31291611-4 2019 Demethylbellidifolin (1) was assayed for its inhibitory HCE 2 effect by HCE 2-mediated DDAB hydrolysis, and its potential IC50 value was 3.12 +- 0.64 muM. didodecyldimethylammonium 87-91 carboxylesterase 2 Homo sapiens 56-61 31291611-4 2019 Demethylbellidifolin (1) was assayed for its inhibitory HCE 2 effect by HCE 2-mediated DDAB hydrolysis, and its potential IC50 value was 3.12 +- 0.64 muM. didodecyldimethylammonium 87-91 carboxylesterase 2 Homo sapiens 72-77 31291611-7 2019 Molecular docking indicated potential interactions of demethylbellidifolin (1) with HCE 2 through two hydrogen bonds of the C-3 and C-5 hydroxy groups with amino acid residues Glu227 and Ser228 in the catalytic cavity, respectively. demethylbellidifolin 54-74 carboxylesterase 2 Homo sapiens 84-89 31291611-7 2019 Molecular docking indicated potential interactions of demethylbellidifolin (1) with HCE 2 through two hydrogen bonds of the C-3 and C-5 hydroxy groups with amino acid residues Glu227 and Ser228 in the catalytic cavity, respectively. Hydrogen 102-110 carboxylesterase 2 Homo sapiens 84-89 31084025-8 2019 in order to find the lowest enthalpy water-ice crystalline structures in the pressure region 0-8000 bar, in unit cells holding in the range of 1-16 molecules, and a database of the 10 lowest enthalpy structures found at pressures 0, 4000, and 8000 bar is presented. Water 37-42 carboxylesterase 2 Homo sapiens 43-46 31175950-3 2019 To this end, betulinic acid (BA) was found with strong inhibitory effect on CES1 (IC50, 15 nM) and relative high selectivity over CES2 (>2400-fold). betulinic acid 13-27 carboxylesterase 2 Homo sapiens 130-134 31175950-3 2019 To this end, betulinic acid (BA) was found with strong inhibitory effect on CES1 (IC50, 15 nM) and relative high selectivity over CES2 (>2400-fold). betulinic acid 29-31 carboxylesterase 2 Homo sapiens 130-134 30872054-0 2019 Flavonoids as human carboxylesterase 2 inhibitors: Inhibition potentials and molecular docking simulations. Flavonoids 0-10 carboxylesterase 2 Homo sapiens 20-38 30872054-1 2019 In our search for natural human carboxylesterase 2 (hCE 2) inhibitors from natural products, we investigated inhibitory effects and mechanisms of flavonoids (1-16) against hCE 2. Flavonoids 146-156 carboxylesterase 2 Homo sapiens 172-177 31175950-2 2019 In this study, a series of natural pentacyclic triterpenoids were collected and their inhibitory effects against CES1 and CES2 were assayed using D-luciferin methyl ester (DME) and N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-benzo[de] isoquinolin- 6-yl)- 2-chloroacetamide (NCEN) as specific optical substrate for CES1, and CES2, respectively. triterpenoids 47-60 carboxylesterase 2 Homo sapiens 122-126 31175950-2 2019 In this study, a series of natural pentacyclic triterpenoids were collected and their inhibitory effects against CES1 and CES2 were assayed using D-luciferin methyl ester (DME) and N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-benzo[de] isoquinolin- 6-yl)- 2-chloroacetamide (NCEN) as specific optical substrate for CES1, and CES2, respectively. triterpenoids 47-60 carboxylesterase 2 Homo sapiens 316-320 31170387-3 2019 The results demonstrate that magnolol strongly inhibits hCE1-mediated hydrolysis of various substrates, whereas the inhibition of hCE2 by magnolol is substrate-dependent, ranging from strong to moderate. magnolol 138-146 carboxylesterase 2 Homo sapiens 130-134 31170387-4 2019 Inhibition of intracellular hCE1 and hCE2 by magnolol was also investigated in living HepG2 cells, and the results showed that magnolol could strongly inhibit intracellular hCE1, while the inhibition of intracellular hCE2 was weak. magnolol 45-53 carboxylesterase 2 Homo sapiens 37-41 31170387-4 2019 Inhibition of intracellular hCE1 and hCE2 by magnolol was also investigated in living HepG2 cells, and the results showed that magnolol could strongly inhibit intracellular hCE1, while the inhibition of intracellular hCE2 was weak. magnolol 127-135 carboxylesterase 2 Homo sapiens 37-41 31170387-4 2019 Inhibition of intracellular hCE1 and hCE2 by magnolol was also investigated in living HepG2 cells, and the results showed that magnolol could strongly inhibit intracellular hCE1, while the inhibition of intracellular hCE2 was weak. magnolol 127-135 carboxylesterase 2 Homo sapiens 217-221 31170387-5 2019 Inhibition kinetic analyses and docking simulations revealed that magnolol inhibited both hCE1 and hCE2 in a mixed manner, which could be partially attributed to its binding at two distinct ligand-binding sites in each carboxylesterase, including the catalytic cavity and the regulatory domain. magnolol 66-74 carboxylesterase 2 Homo sapiens 99-103 30991064-4 2019 Alismanin I (1) displayed significantly inhibitory activity against human CES 2 with IC50 value of 1.31 +- 0.09 muM assayed by human CES 2-mediated DDAB hydrolysis. alismanin i (1) 0-15 carboxylesterase 2 Homo sapiens 74-79 30991064-4 2019 Alismanin I (1) displayed significantly inhibitory activity against human CES 2 with IC50 value of 1.31 +- 0.09 muM assayed by human CES 2-mediated DDAB hydrolysis. alismanin i (1) 0-15 carboxylesterase 2 Homo sapiens 133-138 30991064-4 2019 Alismanin I (1) displayed significantly inhibitory activity against human CES 2 with IC50 value of 1.31 +- 0.09 muM assayed by human CES 2-mediated DDAB hydrolysis. didodecyldimethylammonium 148-152 carboxylesterase 2 Homo sapiens 74-79 30991064-4 2019 Alismanin I (1) displayed significantly inhibitory activity against human CES 2 with IC50 value of 1.31 +- 0.09 muM assayed by human CES 2-mediated DDAB hydrolysis. didodecyldimethylammonium 148-152 carboxylesterase 2 Homo sapiens 133-138 31176327-9 2019 This suggests that one must look elsewhere, possibly at water-induced surface rearrangements or some other "defect" structure, for an explanation of ice nucleation by K-feldspar. Water 56-61 carboxylesterase 2 Homo sapiens 149-152 31128057-4 2019 This study aim was to evaluate the impact of salvage chemotherapy ICE (ifosfamide,carboplatin, and etoposide) versus TC (topotecan/cyclophosphamide) when administered to NBL HR patients havingresidual bone marrow disease after primary tumor control on the first line treatment regimen. Ifosfamide 71-81 carboxylesterase 2 Homo sapiens 66-69 30989159-7 2019 The results indicate that a single Ce atom and a Ce2 cluster can react with a maximum of four and six water molecules, respectively, while a Ce3 cluster can react with more than six water molecules. Water 102-107 carboxylesterase 2 Homo sapiens 49-52 30878380-5 2019 The metabolic activation rate of the enol ester prodrug in HLM solution was similar to that in hCES1 solution, and the enol ester prodrug was found to behave differently from alcohol ester prodrugs, which were metabolically activated by hCES2. enol ester 37-47 carboxylesterase 2 Homo sapiens 237-242 30878380-5 2019 The metabolic activation rate of the enol ester prodrug in HLM solution was similar to that in hCES1 solution, and the enol ester prodrug was found to behave differently from alcohol ester prodrugs, which were metabolically activated by hCES2. enol ester 119-129 carboxylesterase 2 Homo sapiens 237-242 30878380-5 2019 The metabolic activation rate of the enol ester prodrug in HLM solution was similar to that in hCES1 solution, and the enol ester prodrug was found to behave differently from alcohol ester prodrugs, which were metabolically activated by hCES2. alcohol ester 175-188 carboxylesterase 2 Homo sapiens 237-242 30989159-7 2019 The results indicate that a single Ce atom and a Ce2 cluster can react with a maximum of four and six water molecules, respectively, while a Ce3 cluster can react with more than six water molecules. Water 182-187 carboxylesterase 2 Homo sapiens 49-52 30817888-5 2019 In 0.01 M NaCl, ice recrystallization was effectively inhibited by 5.0 mg/mL CNCs or 2.0 mg/mL TEMPO-CNFs. Sodium Chloride 10-14 carboxylesterase 2 Homo sapiens 16-19 30740789-1 2019 An ice/salt-assisted strategy has been developed to achieve the green and efficient synthesis of ultrathin two-dimensional (2D) micro/mesoporous carbon nanosheets (CNS) with the dominant active moieties of Fe-N4 (Fe-N-CNS) as high-performance electrocatalysts for the oxygen reduction reaction (ORR). Carbon 145-151 carboxylesterase 2 Homo sapiens 3-6 30740789-1 2019 An ice/salt-assisted strategy has been developed to achieve the green and efficient synthesis of ultrathin two-dimensional (2D) micro/mesoporous carbon nanosheets (CNS) with the dominant active moieties of Fe-N4 (Fe-N-CNS) as high-performance electrocatalysts for the oxygen reduction reaction (ORR). fe-n4 206-211 carboxylesterase 2 Homo sapiens 3-6 30740789-1 2019 An ice/salt-assisted strategy has been developed to achieve the green and efficient synthesis of ultrathin two-dimensional (2D) micro/mesoporous carbon nanosheets (CNS) with the dominant active moieties of Fe-N4 (Fe-N-CNS) as high-performance electrocatalysts for the oxygen reduction reaction (ORR). Iron 206-210 carboxylesterase 2 Homo sapiens 3-6 30740789-1 2019 An ice/salt-assisted strategy has been developed to achieve the green and efficient synthesis of ultrathin two-dimensional (2D) micro/mesoporous carbon nanosheets (CNS) with the dominant active moieties of Fe-N4 (Fe-N-CNS) as high-performance electrocatalysts for the oxygen reduction reaction (ORR). Oxygen 268-274 carboxylesterase 2 Homo sapiens 3-6 30740789-2 2019 The strategy involves freeze-drying a mixture of iron porphyrin and KCl salt using ice as template followed by a confined pyrolysis with KCl as an independent sealed nanoreactor to facilitate the formation of 2D carbon nanosheets, N incorporation, and porosity creation. kcl salt 68-76 carboxylesterase 2 Homo sapiens 83-86 30740789-2 2019 The strategy involves freeze-drying a mixture of iron porphyrin and KCl salt using ice as template followed by a confined pyrolysis with KCl as an independent sealed nanoreactor to facilitate the formation of 2D carbon nanosheets, N incorporation, and porosity creation. Potassium Chloride 68-71 carboxylesterase 2 Homo sapiens 83-86 30867471-1 2019 Carboxylesterase 2 (CES2) is instrumental for conversion of ester-containing prodrugs in cancer treatment. Esters 8-13 carboxylesterase 2 Homo sapiens 20-24 30960330-2 2019 For four types of PCE molecules-PCE1, PCE2, PCE3, and PCE4-the steric hindrance between the PCE molecules increased with increasing side chain length. pce 18-21 carboxylesterase 2 Homo sapiens 38-42 30611737-8 2019 As a consequence, even sodium azide-induced toxicity to HCE-2 cells in culture is blunted by red light. Sodium Azide 23-35 carboxylesterase 2 Homo sapiens 56-61 30793135-4 2019 In our work, we use computer simulations with the TIP4P/Ice water model to investigate such a change of slope. Water 60-65 carboxylesterase 2 Homo sapiens 56-59 30775750-2 2019 Reactions of unsymmetrical diphosphanes with CE2 (E = O, S) catalyzed by BPh3 insert a CE2 molecule into the P-P bond with formation of the products of the general formula R2P-E-C([double bond, length as m-dash]E)-PR2. diphosphanes 27-39 carboxylesterase 2 Homo sapiens 45-48 30775750-2 2019 Reactions of unsymmetrical diphosphanes with CE2 (E = O, S) catalyzed by BPh3 insert a CE2 molecule into the P-P bond with formation of the products of the general formula R2P-E-C([double bond, length as m-dash]E)-PR2. diphosphanes 27-39 carboxylesterase 2 Homo sapiens 87-90 30775750-2 2019 Reactions of unsymmetrical diphosphanes with CE2 (E = O, S) catalyzed by BPh3 insert a CE2 molecule into the P-P bond with formation of the products of the general formula R2P-E-C([double bond, length as m-dash]E)-PR2. bph3 73-77 carboxylesterase 2 Homo sapiens 45-48 30775750-2 2019 Reactions of unsymmetrical diphosphanes with CE2 (E = O, S) catalyzed by BPh3 insert a CE2 molecule into the P-P bond with formation of the products of the general formula R2P-E-C([double bond, length as m-dash]E)-PR2. bph3 73-77 carboxylesterase 2 Homo sapiens 87-90 30714061-5 2019 The predicted reaction pathways show that the single Ce atom and the Ce2 and Ce3 clusters can all easily react with H2O and dissociate the water molecule. ce3 77-80 carboxylesterase 2 Homo sapiens 69-72 30714061-5 2019 The predicted reaction pathways show that the single Ce atom and the Ce2 and Ce3 clusters can all easily react with H2O and dissociate the water molecule. Water 116-119 carboxylesterase 2 Homo sapiens 69-72 30714061-5 2019 The predicted reaction pathways show that the single Ce atom and the Ce2 and Ce3 clusters can all easily react with H2O and dissociate the water molecule. Water 139-144 carboxylesterase 2 Homo sapiens 69-72 30714061-7 2019 The reaction of either Ce2 or Ce3 with a single H2O molecule can fully dissociate the H2O into H and O atoms while it is bonded with the Ce cluster. Water 48-51 carboxylesterase 2 Homo sapiens 23-26 30714061-7 2019 The reaction of either Ce2 or Ce3 with a single H2O molecule can fully dissociate the H2O into H and O atoms while it is bonded with the Ce cluster. Water 86-89 carboxylesterase 2 Homo sapiens 23-26 29600756-9 2019 RESULTS: The results showed that more than 50 natural inhibitors of CES1 or CES2, including phenolic chemicals, triterpenoids, and tanshinones were found from herbs, whereas only few inducers of CES1 and CES2 were reported. triterpenoids 112-125 carboxylesterase 2 Homo sapiens 76-80 30267780-3 2019 To obtain a better understanding of selexipag metabolism in humans, we determined the percentage contribution of CES1 and carboxylesterase 2 (CES2) to the hydrolysis of selexipag and 7 of its analogs with different sulfonamide moieties and evaluated its nonhydrolytic metabolism in human liver microsomes and human intestinal microsomes (HIMS). selexipag 169-178 carboxylesterase 2 Homo sapiens 122-140 30267780-3 2019 To obtain a better understanding of selexipag metabolism in humans, we determined the percentage contribution of CES1 and carboxylesterase 2 (CES2) to the hydrolysis of selexipag and 7 of its analogs with different sulfonamide moieties and evaluated its nonhydrolytic metabolism in human liver microsomes and human intestinal microsomes (HIMS). selexipag 169-178 carboxylesterase 2 Homo sapiens 142-146 30267780-3 2019 To obtain a better understanding of selexipag metabolism in humans, we determined the percentage contribution of CES1 and carboxylesterase 2 (CES2) to the hydrolysis of selexipag and 7 of its analogs with different sulfonamide moieties and evaluated its nonhydrolytic metabolism in human liver microsomes and human intestinal microsomes (HIMS). Sulfonamides 215-226 carboxylesterase 2 Homo sapiens 142-146 30267780-3 2019 To obtain a better understanding of selexipag metabolism in humans, we determined the percentage contribution of CES1 and carboxylesterase 2 (CES2) to the hydrolysis of selexipag and 7 of its analogs with different sulfonamide moieties and evaluated its nonhydrolytic metabolism in human liver microsomes and human intestinal microsomes (HIMS). hims 338-342 carboxylesterase 2 Homo sapiens 142-146 30267780-6 2019 We infer from these results that selexipag is likely to be hydrolyzed by CES2 as well as CES1, and only selexipag itself and the MRE-269 produced by hydrolysis in the intestine would be absorbed after oral administration. selexipag 33-42 carboxylesterase 2 Homo sapiens 73-77 30565926-1 2019 The monomer [Ce(COT)2]- and the dimer [Ce2(COT)3], with Ce(III) and COT = 1,3,5,7-cyclooctatetraenide, are studied by quantum chemistry calculations. 1,3,5,7-cyclooctatetraenide 74-101 carboxylesterase 2 Homo sapiens 39-48 30551482-11 2019 Additionally, a potent inhibitory effect of GQT extract against hCE2 was observedin vitro, with its IC50 value of 0.187 mg/ml, suggesting alleviating activity on hCE2-mediated severe diarrhea in patients suffered from CPT-11. Irinotecan 218-224 carboxylesterase 2 Homo sapiens 64-68 30551482-11 2019 Additionally, a potent inhibitory effect of GQT extract against hCE2 was observedin vitro, with its IC50 value of 0.187 mg/ml, suggesting alleviating activity on hCE2-mediated severe diarrhea in patients suffered from CPT-11. Irinotecan 218-224 carboxylesterase 2 Homo sapiens 162-166 29468758-3 2018 In this study, the inhibitory effects of shikonin on the activity of hCE2 in human liver microsomes are investigated by using fluorescein diacetate (FD), N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-phenalen-6-yl)-2-chloroacetamide (NCEN), and CPT-11 as substrates of hCE2. ncen 224-228 carboxylesterase 2 Homo sapiens 69-73 30268757-3 2018 To this end, fifty-eight natural flavonoids were collected and their inhibitory effects against both hCE1 and hCE2 were assayed. Flavonoids 33-43 carboxylesterase 2 Homo sapiens 110-114 30442353-0 2018 Polymorphisms in IMPDH2, UGT2B7, and CES2 genes influence the risk of graft rejection in kidney transplant recipients taking mycophenolate mofetil. Mycophenolic Acid 125-146 carboxylesterase 2 Homo sapiens 37-41 30466609-1 2018 BACKGROUND: Carboxylesterases (CEs) belong to the serine hydrolase family, and are in charge of hydrolyzing chemicals with carboxylic acid ester and amide functional groups via Ser-His-Glu. carboxylic acid ester 123-144 carboxylesterase 2 Homo sapiens 12-29 30466609-1 2018 BACKGROUND: Carboxylesterases (CEs) belong to the serine hydrolase family, and are in charge of hydrolyzing chemicals with carboxylic acid ester and amide functional groups via Ser-His-Glu. Amides 149-154 carboxylesterase 2 Homo sapiens 12-29 30466609-1 2018 BACKGROUND: Carboxylesterases (CEs) belong to the serine hydrolase family, and are in charge of hydrolyzing chemicals with carboxylic acid ester and amide functional groups via Ser-His-Glu. Serine 177-180 carboxylesterase 2 Homo sapiens 12-29 30466609-1 2018 BACKGROUND: Carboxylesterases (CEs) belong to the serine hydrolase family, and are in charge of hydrolyzing chemicals with carboxylic acid ester and amide functional groups via Ser-His-Glu. Histidine 181-184 carboxylesterase 2 Homo sapiens 12-29 30466609-1 2018 BACKGROUND: Carboxylesterases (CEs) belong to the serine hydrolase family, and are in charge of hydrolyzing chemicals with carboxylic acid ester and amide functional groups via Ser-His-Glu. Glutamic Acid 185-188 carboxylesterase 2 Homo sapiens 12-29 29363498-6 2018 The drug metabolizing enzyme activities of both CCHHs and MMHHs were cell concentration and time dependent, with specific activities of MMHHs ranging from 27.2% (carboxylesterase 2) to 234.2% (acetaminophen GSH conjugation) of that for CCHHs. cchhs 48-53 carboxylesterase 2 Homo sapiens 162-180 30384747-1 2018 Using molecular dynamics simulations, we assess the uniaxial deformation response of ice I h as described by two popular water models, namely, the all-atom TIP4P/Ice potential and the coarse-grained mW model. Water 121-126 carboxylesterase 2 Homo sapiens 85-88 30028988-0 2018 In vitro approach to elucidate the relevance of carboxylesterase 2 and N-acetyltransferase 2 to flupirtine-induced liver injury. flupirtine 96-106 carboxylesterase 2 Homo sapiens 48-66 30028988-5 2018 Using recombinant enzymes, we found that D-13223 was formed from flupirtine via hydrolysis by carboxylesterase 2 (CES2) and subsequent acetylation by N-acetyltransferase (NAT) 2. flupirtine 65-75 carboxylesterase 2 Homo sapiens 94-112 30028988-5 2018 Using recombinant enzymes, we found that D-13223 was formed from flupirtine via hydrolysis by carboxylesterase 2 (CES2) and subsequent acetylation by N-acetyltransferase (NAT) 2. flupirtine 65-75 carboxylesterase 2 Homo sapiens 114-118 30028988-6 2018 A conjugate of N-acetyl-l-cysteine (NAC), a nucleophile, was detected by incubation of flupirtine with CES2, and the conjugate formation in human liver microsomes was inhibited by CES2 inhibitors, indicating that a reactive metabolite, which may be a quinone diimine, was produced in the process of CES2-mediated hydrolysis of flupirtine. flupirtine 87-97 carboxylesterase 2 Homo sapiens 103-107 30028988-8 2018 CES2-overexpressing HepG2 cells showed remarkable lactate dehydrogenase leakage under flupirtine treatment, while no cytotoxicity was observed in control cells, suggesting that the reactive metabolite formed by CES2-mediated hydrolysis of flupirtine would be a trigger of hepatotoxicity. flupirtine 86-96 carboxylesterase 2 Homo sapiens 0-4 30028988-8 2018 CES2-overexpressing HepG2 cells showed remarkable lactate dehydrogenase leakage under flupirtine treatment, while no cytotoxicity was observed in control cells, suggesting that the reactive metabolite formed by CES2-mediated hydrolysis of flupirtine would be a trigger of hepatotoxicity. flupirtine 86-96 carboxylesterase 2 Homo sapiens 211-215 30028988-8 2018 CES2-overexpressing HepG2 cells showed remarkable lactate dehydrogenase leakage under flupirtine treatment, while no cytotoxicity was observed in control cells, suggesting that the reactive metabolite formed by CES2-mediated hydrolysis of flupirtine would be a trigger of hepatotoxicity. flupirtine 239-249 carboxylesterase 2 Homo sapiens 0-4 30028988-8 2018 CES2-overexpressing HepG2 cells showed remarkable lactate dehydrogenase leakage under flupirtine treatment, while no cytotoxicity was observed in control cells, suggesting that the reactive metabolite formed by CES2-mediated hydrolysis of flupirtine would be a trigger of hepatotoxicity. flupirtine 239-249 carboxylesterase 2 Homo sapiens 211-215 30028988-9 2018 NAT2 slow acetylators with high CES2 activity could be highly susceptible to flupirtine-induced liver injury. flupirtine 77-87 carboxylesterase 2 Homo sapiens 32-36 30047956-0 2018 An iridium complex-based probe for photoluminescence lifetime imaging of human carboxylesterase 2 in living cells. Iridium 3-10 carboxylesterase 2 Homo sapiens 79-97 29533079-0 2018 Ice in the Outback: the epidemiology of amphetamine-type stimulant-related hospital admissions and presentations to the emergency department in Hedland, Western Australia. Amphetamine 40-51 carboxylesterase 2 Homo sapiens 0-3 30574730-0 2018 The "Ice" Storm: Problems with Expert Evidence on the Effects of Methamphetamine. Methamphetamine 65-80 carboxylesterase 2 Homo sapiens 5-8 30574730-1 2018 There is growing community concern that methamphetamine (commonly known as Ice) is fuelling violent, erratic and criminal behaviour. Methamphetamine 40-55 carboxylesterase 2 Homo sapiens 75-78 30426995-6 2018 It was found that the Ce2 emission intensity is continuously enhanced relative to that of Ce1 with an increasing Ce3+ concentration, thus leading to a redshift of the broadband. ce3+ 113-117 carboxylesterase 2 Homo sapiens 22-25 30426995-7 2018 Meanwhile, a more notable fluorescence lifetime shortening of Ce1 compared to Ce2 with an increasing Ce3+ concentration was observed. ce3+ 101-105 carboxylesterase 2 Homo sapiens 78-81 30251528-0 2018 Photodegradation Rate Constants for Anthracene and Pyrene Are Similar in/on Ice and in Aqueous Solution. anthracene 36-46 carboxylesterase 2 Homo sapiens 76-79 30251528-0 2018 Photodegradation Rate Constants for Anthracene and Pyrene Are Similar in/on Ice and in Aqueous Solution. pyrene 51-57 carboxylesterase 2 Homo sapiens 76-79 30251528-5 2018 Here we examine the photodegradation of two common PAHs, anthracene and pyrene, in/on ice and in solution. Polycyclic Aromatic Hydrocarbons 51-55 carboxylesterase 2 Homo sapiens 86-89 30251528-5 2018 Here we examine the photodegradation of two common PAHs, anthracene and pyrene, in/on ice and in solution. anthracene 57-67 carboxylesterase 2 Homo sapiens 86-89 30251528-5 2018 Here we examine the photodegradation of two common PAHs, anthracene and pyrene, in/on ice and in solution. pyrene 72-78 carboxylesterase 2 Homo sapiens 86-89 30251528-6 2018 For a given PAH, rate constants are similar in aqueous solution, in internal liquid-like regions of ice, and at the air-ice interface. Polycyclic Aromatic Hydrocarbons 12-15 carboxylesterase 2 Homo sapiens 100-103 30251528-6 2018 For a given PAH, rate constants are similar in aqueous solution, in internal liquid-like regions of ice, and at the air-ice interface. Polycyclic Aromatic Hydrocarbons 12-15 carboxylesterase 2 Homo sapiens 120-123 30159998-4 2018 The significant changes in geometry induced by a relatively mild temperature increase underline the importance of temperature for the shape and all properties influenced by this shape of hydrogen-bonded clusters of water ice. Hydrogen 187-195 carboxylesterase 2 Homo sapiens 221-224 30159998-4 2018 The significant changes in geometry induced by a relatively mild temperature increase underline the importance of temperature for the shape and all properties influenced by this shape of hydrogen-bonded clusters of water ice. Water 215-220 carboxylesterase 2 Homo sapiens 221-224 30078983-10 2018 Both CE-CKC emulsions inhibited the secretion of IL-17 (from anti-CD3/anti-CD28-stimulated TCD4), TNFalpha, IFN-gamma, and IL-2 (from anti-CD3-/anti-CD28-stimulated PBMCs), and IL-6 and IL-8 (from LPS-stimulated HCE-2). ce-ckc 5-11 carboxylesterase 2 Homo sapiens 212-217 30078983-12 2018 In addition, tyloxapol, another excipient, showed some anti-inflammatory activity on IL-6 and IL-8 in the LPS-stimulated HCE-2 cells. tyloxapol 13-22 carboxylesterase 2 Homo sapiens 121-126 29468758-3 2018 In this study, the inhibitory effects of shikonin on the activity of hCE2 in human liver microsomes are investigated by using fluorescein diacetate (FD), N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-phenalen-6-yl)-2-chloroacetamide (NCEN), and CPT-11 as substrates of hCE2. shikonin 41-49 carboxylesterase 2 Homo sapiens 69-73 29468758-3 2018 In this study, the inhibitory effects of shikonin on the activity of hCE2 in human liver microsomes are investigated by using fluorescein diacetate (FD), N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-phenalen-6-yl)-2-chloroacetamide (NCEN), and CPT-11 as substrates of hCE2. shikonin 41-49 carboxylesterase 2 Homo sapiens 259-263 29468758-3 2018 In this study, the inhibitory effects of shikonin on the activity of hCE2 in human liver microsomes are investigated by using fluorescein diacetate (FD), N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-phenalen-6-yl)-2-chloroacetamide (NCEN), and CPT-11 as substrates of hCE2. diacetylfluorescein 126-147 carboxylesterase 2 Homo sapiens 69-73 29468758-3 2018 In this study, the inhibitory effects of shikonin on the activity of hCE2 in human liver microsomes are investigated by using fluorescein diacetate (FD), N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-phenalen-6-yl)-2-chloroacetamide (NCEN), and CPT-11 as substrates of hCE2. Irinotecan 235-241 carboxylesterase 2 Homo sapiens 69-73 29468758-4 2018 The results demonstrate that shikonin significantly inhibits the activity of hCE2 when FD and NCEN are used as substrates, whereas the half inhibition concentration value of shikonin increased by 5-30 times when CPT-11 was used as the substrate. Irinotecan 212-218 carboxylesterase 2 Homo sapiens 77-81 29421708-0 2018 Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2. Flavonoids 64-74 carboxylesterase 2 Homo sapiens 103-121 29407485-6 2018 Inhibition studies revealed that the FD hydrolysis was inhibited by bis-p-nitrophenylphosphate, phenylmethanesulfonyl fluoride, and loperamide (specific for CES2), whereas the pNPA and 4-MUA hydrolysis inhibition was limited. bis(4-nitrophenyl)phosphate 68-94 carboxylesterase 2 Homo sapiens 157-161 29407485-6 2018 Inhibition studies revealed that the FD hydrolysis was inhibited by bis-p-nitrophenylphosphate, phenylmethanesulfonyl fluoride, and loperamide (specific for CES2), whereas the pNPA and 4-MUA hydrolysis inhibition was limited. Loperamide 132-142 carboxylesterase 2 Homo sapiens 157-161 29421708-2 2018 Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the metabolic activation of ester drugs including irinotecan and flutamide. hces 21-25 carboxylesterase 2 Homo sapiens 33-51 29421708-2 2018 Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the metabolic activation of ester drugs including irinotecan and flutamide. hces 21-25 carboxylesterase 2 Homo sapiens 53-57 29421708-2 2018 Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the metabolic activation of ester drugs including irinotecan and flutamide. Esters 41-46 carboxylesterase 2 Homo sapiens 53-57 29421708-2 2018 Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the metabolic activation of ester drugs including irinotecan and flutamide. Irinotecan 132-142 carboxylesterase 2 Homo sapiens 33-51 29421708-2 2018 Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the metabolic activation of ester drugs including irinotecan and flutamide. Irinotecan 132-142 carboxylesterase 2 Homo sapiens 53-57 29421708-2 2018 Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the metabolic activation of ester drugs including irinotecan and flutamide. Flutamide 147-156 carboxylesterase 2 Homo sapiens 33-51 29421708-2 2018 Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the metabolic activation of ester drugs including irinotecan and flutamide. Flutamide 147-156 carboxylesterase 2 Homo sapiens 53-57 29421708-4 2018 In this study, more than fifty flavonoids were collected to assay their inhibitory effects against hCE2 using a fluorescence-based method. Flavonoids 31-41 carboxylesterase 2 Homo sapiens 99-103 29421708-6 2018 Among all tested flavonoids, 5,6-dihydroxyflavone displayed the most potent inhibitory effect against hCE2 with the IC50 value of 3.50 muM. Flavonoids 17-27 carboxylesterase 2 Homo sapiens 102-106 29421708-6 2018 Among all tested flavonoids, 5,6-dihydroxyflavone displayed the most potent inhibitory effect against hCE2 with the IC50 value of 3.50 muM. 5,6-DIHYDROXYFLAVONE 29-49 carboxylesterase 2 Homo sapiens 102-106 29421708-8 2018 All these findings are very helpful for the medicinal chemists to design and develop more potent and highly selective flavonoid-type hCE2 inhibitors. Flavonoids 118-127 carboxylesterase 2 Homo sapiens 133-137 29261002-0 2018 Expression of Topoisomerase 1 and carboxylesterase 2 correlates with irinotecan treatment response in metastatic colorectal cancer. Irinotecan 69-79 carboxylesterase 2 Homo sapiens 34-52 28792260-1 2018 This phase-I/phase-II study evaluated panobinostat in combination with ifosfamide, carboplatin, etoposide (P-ICE) in relapsed/refractory classical Hodgkin lymphoma. Panobinostat 38-50 carboxylesterase 2 Homo sapiens 109-112 28792260-2 2018 During phase I, panobinostat was given daily on Monday/Wednesday/Friday starting one week prior to Cycle 1 (C1) of ICE and during two weeks of C1-2 of ICE (Schedule A). Panobinostat 16-28 carboxylesterase 2 Homo sapiens 115-118 28792260-5 2018 In the randomized phase-II study, CR was seen in 9/11 (82%) and 8/12 (67%) for P-ICE and ICE, respectively (p = .64). Chromium 34-36 carboxylesterase 2 Homo sapiens 79-92 29261002-13 2018 In summary, our findings suggest that TOPO-1 and CES-2 may play important roles irinotecan sensitivity in mCRC patients. Irinotecan 80-90 carboxylesterase 2 Homo sapiens 49-54 29261002-14 2018 Evaluation of expression of TOPO-1 and CES-2 may provide preliminary clinical evidence for the management of irinotecan-based therapy in mCRC patients. Irinotecan 109-119 carboxylesterase 2 Homo sapiens 39-44 29604711-1 2018 A full-field perturbation approach is modified for an ice-covered ocean and applied to estimating narrowband long-range reverberation caused by roughness of the ice-water interface. Water 165-170 carboxylesterase 2 Homo sapiens 161-164 29353723-8 2018 Docking simulation also demonstrated that active compound 1 created interaction with the Ser-288 (the catalytic amino-acid in the catalytic cavity) of hCE2 via hydrogen bonding, revealing its highly selective inhibition toward hCE2. Serine 89-92 carboxylesterase 2 Homo sapiens 151-155 29963254-3 2018 In the animal model for irinotecan (CPT-11) induced CID, Hst could selectively inhibit intestinal carboxylesterase (CES2) and thus reduce the local conversion of CPT-11 to cytotoxic SN-38 which causes intestinal toxicity. Irinotecan 24-34 carboxylesterase 2 Homo sapiens 116-120 29963254-3 2018 In the animal model for irinotecan (CPT-11) induced CID, Hst could selectively inhibit intestinal carboxylesterase (CES2) and thus reduce the local conversion of CPT-11 to cytotoxic SN-38 which causes intestinal toxicity. Irinotecan 36-42 carboxylesterase 2 Homo sapiens 116-120 29263072-0 2018 Effect of Genetic Variation of NAT2 on Isoniazid and SLCO1B1 and CES2 on Rifampin Pharmacokinetics in Ghanaian Children with Tuberculosis. Rifampin 73-81 carboxylesterase 2 Homo sapiens 65-69 29353723-8 2018 Docking simulation also demonstrated that active compound 1 created interaction with the Ser-288 (the catalytic amino-acid in the catalytic cavity) of hCE2 via hydrogen bonding, revealing its highly selective inhibition toward hCE2. Serine 89-92 carboxylesterase 2 Homo sapiens 227-231 29353723-8 2018 Docking simulation also demonstrated that active compound 1 created interaction with the Ser-288 (the catalytic amino-acid in the catalytic cavity) of hCE2 via hydrogen bonding, revealing its highly selective inhibition toward hCE2. Hydrogen 160-168 carboxylesterase 2 Homo sapiens 151-155 29353723-8 2018 Docking simulation also demonstrated that active compound 1 created interaction with the Ser-288 (the catalytic amino-acid in the catalytic cavity) of hCE2 via hydrogen bonding, revealing its highly selective inhibition toward hCE2. Hydrogen 160-168 carboxylesterase 2 Homo sapiens 227-231 29342444-8 2018 Streptococcal toxin encoding prophage phiHKU.vir and phiHKU.ssa in addition to the macrolide and tetracycline resistant ICE-emm12 and ICE-HKU397 elements were found amongst mainland China multi-clonal emm12 isolates suggesting a role in selection and expansion of scarlet fever lineages in China. Tetracycline 97-109 carboxylesterase 2 Homo sapiens 120-123 29426888-7 2018 Tbrain and Tre significantly reduced after ingestion of ICE compared with after ingestion of CON, and there was a significant correlation between Tbrain and Tre. tbrain 0-6 carboxylesterase 2 Homo sapiens 56-59 29426888-2 2018 Therefore, in the current study, we investigated the effect of ice slurry ingestion on Tbrain using proton magnetic resonance spectroscopy, which is a robust, non-invasive method. tbrain 87-93 carboxylesterase 2 Homo sapiens 63-66 28827188-0 2018 Single-nucleotide polymorphisms in the genes of CES2, CDA and enzymatic activity of CDA for prediction of the efficacy of capecitabine-containing chemotherapy in patients with metastatic breast cancer. Capecitabine 122-134 carboxylesterase 2 Homo sapiens 48-52 28827188-12 2018 Since particular SNPs in CDA and CES2 were associated with benefit from the addition of capecitabine to AT, their predictive value should be explored in a higher number of patients. Capecitabine 88-100 carboxylesterase 2 Homo sapiens 33-37 29253734-0 2018 Diterpenoids from the roots of Euphorbia ebracteolata and their inhibitory effects on human carboxylesterase 2. Diterpenes 0-12 carboxylesterase 2 Homo sapiens 92-110 29651325-1 2018 Irinotecan (CPT-11) is an anticancer prodrug that is activated by the carboxylesterase CES2 and has been approved for the treatment of many types of solid tumors, including colorectal cancer. Irinotecan 0-10 carboxylesterase 2 Homo sapiens 70-86 29210644-4 2018 CES2 plays crucial roles in the metabolic activation of many prodrugs including anticancer agents capecitabine and CPT-11. Capecitabine 98-110 carboxylesterase 2 Homo sapiens 0-4 29175444-2 2018 After being treated with 17beta-estradiol, the mRNA levels of CES1 and CES2 decreased by 29-39% and 28-55%, respectively, in the human hepatocytes from four donors. Estradiol 25-41 carboxylesterase 2 Homo sapiens 71-75 29175444-4 2018 Moreover, 17beta-estradiol decreased CES1 and CES2 by 45% and 47% respectively at protein levels. Estradiol 10-26 carboxylesterase 2 Homo sapiens 46-50 29651325-1 2018 Irinotecan (CPT-11) is an anticancer prodrug that is activated by the carboxylesterase CES2 and has been approved for the treatment of many types of solid tumors, including colorectal cancer. Irinotecan 0-10 carboxylesterase 2 Homo sapiens 87-91 29651325-1 2018 Irinotecan (CPT-11) is an anticancer prodrug that is activated by the carboxylesterase CES2 and has been approved for the treatment of many types of solid tumors, including colorectal cancer. Irinotecan 12-18 carboxylesterase 2 Homo sapiens 70-86 29651325-1 2018 Irinotecan (CPT-11) is an anticancer prodrug that is activated by the carboxylesterase CES2 and has been approved for the treatment of many types of solid tumors, including colorectal cancer. Irinotecan 12-18 carboxylesterase 2 Homo sapiens 87-91 29709907-1 2018 Carboxylesterase 2 (CES2), which is a member of the serine hydrolase superfamily, is primarily expressed in the human small intestine, where it plays an important role in the metabolism of ester-containing drugs. Esters 8-13 carboxylesterase 2 Homo sapiens 20-24 29709907-2 2018 Therefore, to facilitate continued progress in ester-containing drug development, it is crucial to evaluate how CES2-mediated hydrolysis influences its intestinal permeability characteristics. Esters 47-52 carboxylesterase 2 Homo sapiens 112-116 29709907-10 2018 Collectively, based on our results clearly showing that CES2/Caco-2CES1KD cells carry the human intestinal-type CES expression profile, while concomitantly retaining their barrier properties, it can be expected that this cell line will provide a promising in vitro model for ester-containing drug permeability studies. Esters 275-280 carboxylesterase 2 Homo sapiens 56-60 29210644-4 2018 CES2 plays crucial roles in the metabolic activation of many prodrugs including anticancer agents capecitabine and CPT-11. Irinotecan 115-121 carboxylesterase 2 Homo sapiens 0-4 29210644-5 2018 Co-administration with CES2 inhibitors may ameliorate CPT-11 associated lifethreatening diarrhea or improve the half-lives of CES2-substrate drugs. Irinotecan 54-60 carboxylesterase 2 Homo sapiens 23-27 28885961-1 2017 BACKGROUND: The procedure of wrapping a heat casualty in ice-water soaked bed sheets to reduce core temperature has received little investigation, despite the practice and recommendation for its use in some military settings. Water 61-66 carboxylesterase 2 Homo sapiens 57-60 29237391-5 2018 For procaine, a known CES2 substrate, the measured apparent clearance was higher in hepatocytes, but formation of 4-aminobenzoic acid, a CE2-specific metabolite, was more pronounced in enterocytes, suggesting that CE2 is more active in enterocytes. Procaine 4-12 carboxylesterase 2 Homo sapiens 22-26 29237391-5 2018 For procaine, a known CES2 substrate, the measured apparent clearance was higher in hepatocytes, but formation of 4-aminobenzoic acid, a CE2-specific metabolite, was more pronounced in enterocytes, suggesting that CE2 is more active in enterocytes. 4-Aminobenzoic Acid 114-133 carboxylesterase 2 Homo sapiens 137-140 29237391-5 2018 For procaine, a known CES2 substrate, the measured apparent clearance was higher in hepatocytes, but formation of 4-aminobenzoic acid, a CE2-specific metabolite, was more pronounced in enterocytes, suggesting that CE2 is more active in enterocytes. 4-Aminobenzoic Acid 114-133 carboxylesterase 2 Homo sapiens 214-217 29125304-0 2017 Homogeneous Nucleation of Ice in Transiently-Heated, Supercooled Liquid Water Films. Water 72-77 carboxylesterase 2 Homo sapiens 26-29 29125304-1 2017 We have investigated the nucleation and growth of crystalline ice in 0.24 mum thick, supercooled water films adsorbed on Pt(111). Water 97-102 carboxylesterase 2 Homo sapiens 62-65 29125304-4 2017 The experimental conditions were chosen to suppress ice nucleation at both the water/metal and water/vacuum interfaces. Water 79-84 carboxylesterase 2 Homo sapiens 52-55 29125304-4 2017 The experimental conditions were chosen to suppress ice nucleation at both the water/metal and water/vacuum interfaces. Metals 85-90 carboxylesterase 2 Homo sapiens 52-55 29125304-4 2017 The experimental conditions were chosen to suppress ice nucleation at both the water/metal and water/vacuum interfaces. Water 95-100 carboxylesterase 2 Homo sapiens 52-55 28817486-4 2017 Of them, metabolic conversion of vicagrel and PLD-301 to 2-oxo-clopidogrel is catalyzed by intestinal carboxylesterase 2 and alkaline phosphatase, respectively. methyl 2-(2-acetoxy-6,7-dihydrothieno(3,2-c)pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate 33-41 carboxylesterase 2 Homo sapiens 102-120 28817486-4 2017 Of them, metabolic conversion of vicagrel and PLD-301 to 2-oxo-clopidogrel is catalyzed by intestinal carboxylesterase 2 and alkaline phosphatase, respectively. 2-oxo-clopidogrel 57-74 carboxylesterase 2 Homo sapiens 102-120 29040802-0 2017 Freezing Temperatures, Ice Nanotubes Structures, and Proton Ordering of TIP4P/ICE Water inside Single Wall Carbon Nanotubes. Water 82-87 carboxylesterase 2 Homo sapiens 78-81 29040802-0 2017 Freezing Temperatures, Ice Nanotubes Structures, and Proton Ordering of TIP4P/ICE Water inside Single Wall Carbon Nanotubes. Carbon 107-113 carboxylesterase 2 Homo sapiens 78-81 29040802-3 2017 We present here results from molecular dynamics simulations of water inside single walled carbon nanotubes using an extremely realistic model for both liquid and icy water, the TIP4P/ICE. Water 63-68 carboxylesterase 2 Homo sapiens 183-186 29040802-7 2017 We have also analyzed the ice structure called "ice nanotube" that water forms inside the single walled carbon nanotubes when it freezes. Water 67-72 carboxylesterase 2 Homo sapiens 26-29 29040802-7 2017 We have also analyzed the ice structure called "ice nanotube" that water forms inside the single walled carbon nanotubes when it freezes. Water 67-72 carboxylesterase 2 Homo sapiens 48-51 29040802-7 2017 We have also analyzed the ice structure called "ice nanotube" that water forms inside the single walled carbon nanotubes when it freezes. Carbon 104-110 carboxylesterase 2 Homo sapiens 26-29 29040802-7 2017 We have also analyzed the ice structure called "ice nanotube" that water forms inside the single walled carbon nanotubes when it freezes. Carbon 104-110 carboxylesterase 2 Homo sapiens 48-51 29040802-8 2017 The ice forms observed are in agreement with previous results obtained with different water models. Water 86-91 carboxylesterase 2 Homo sapiens 4-7 28647665-1 2017 DDAB (6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate) is a newly developed near-infrared fluorescent probe for human carboxylesterase 2 (hCE2), exhibiting high specificity and good reactivity for real-time monitoring the enzymatic activities of hCE2 in complex biological systems. 6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate 0-4 carboxylesterase 2 Homo sapiens 135-153 28647665-1 2017 DDAB (6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate) is a newly developed near-infrared fluorescent probe for human carboxylesterase 2 (hCE2), exhibiting high specificity and good reactivity for real-time monitoring the enzymatic activities of hCE2 in complex biological systems. 6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate 0-4 carboxylesterase 2 Homo sapiens 155-159 28647665-1 2017 DDAB (6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate) is a newly developed near-infrared fluorescent probe for human carboxylesterase 2 (hCE2), exhibiting high specificity and good reactivity for real-time monitoring the enzymatic activities of hCE2 in complex biological systems. 6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate 0-4 carboxylesterase 2 Homo sapiens 263-267 28823159-6 2017 Here we use molecular simulations to investigate the mechanism of ice nucleation promoted by an alcohol monolayer. Alcohols 96-103 carboxylesterase 2 Homo sapiens 66-69 29158727-3 2017 We present a case of a 24-year-old male with classical nodular sclerosing Hodgkin lymphoma who achieved near complete remission following 5 cycles of brentuximab concurrent with ISRT (involved site radiation therapy) following progression of first-line ABVD (Adriamycin, bleomycin, vinblastine, dacarbazine) and subsequent second-line ICE (ifosfamide, carboplatin, etoposide) chemotherapy. SGN-30 monoclonal antibody 150-161 carboxylesterase 2 Homo sapiens 335-338 29366426-2 2018 Unfortunately there are not many treatment options, but promising responses have been reported with ifosfamide, etoposide and carboplatin (ICE). Ifosfamide 100-110 carboxylesterase 2 Homo sapiens 139-142 29366426-2 2018 Unfortunately there are not many treatment options, but promising responses have been reported with ifosfamide, etoposide and carboplatin (ICE). Carboplatin 126-137 carboxylesterase 2 Homo sapiens 139-142 29240710-6 2017 Laboratory results indicate that the proposed sensor can effectively detect surface ice and wet conditions even in the presence of deicing chlorides and rubber residue. Chlorides 139-148 carboxylesterase 2 Homo sapiens 84-87 29209217-2 2017 Some studies have shown that vicagrel undergoes complete first-pass metabolism in human intestine, generating the hydrolytic metabolite 2-oxo-clopidogrel via carboxylesterase-2 (CES2) and subsequently the active metabolite H4 via CYP450s. methyl 2-(2-acetoxy-6,7-dihydrothieno(3,2-c)pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate 29-37 carboxylesterase 2 Homo sapiens 158-176 29209217-2 2017 Some studies have shown that vicagrel undergoes complete first-pass metabolism in human intestine, generating the hydrolytic metabolite 2-oxo-clopidogrel via carboxylesterase-2 (CES2) and subsequently the active metabolite H4 via CYP450s. methyl 2-(2-acetoxy-6,7-dihydrothieno(3,2-c)pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate 29-37 carboxylesterase 2 Homo sapiens 178-182 29209217-2 2017 Some studies have shown that vicagrel undergoes complete first-pass metabolism in human intestine, generating the hydrolytic metabolite 2-oxo-clopidogrel via carboxylesterase-2 (CES2) and subsequently the active metabolite H4 via CYP450s. 2-oxo-clopidogrel 136-153 carboxylesterase 2 Homo sapiens 158-176 29209217-2 2017 Some studies have shown that vicagrel undergoes complete first-pass metabolism in human intestine, generating the hydrolytic metabolite 2-oxo-clopidogrel via carboxylesterase-2 (CES2) and subsequently the active metabolite H4 via CYP450s. 2-oxo-clopidogrel 136-153 carboxylesterase 2 Homo sapiens 178-182 29209217-3 2017 This study aimed to identify hydrolases other than CES2 that are involved in the bioactivation of vicagrel in human intestine. methyl 2-(2-acetoxy-6,7-dihydrothieno(3,2-c)pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate 98-106 carboxylesterase 2 Homo sapiens 51-55 29209217-6 2017 The calculated contribution of CES2 and AADAC to vicagrel hydrolysis was 44.2 and 53.1% in human intestine, respectively. methyl 2-(2-acetoxy-6,7-dihydrothieno(3,2-c)pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate 49-57 carboxylesterase 2 Homo sapiens 31-35 28793774-6 2017 The phase diagram obtained in this work, which is found to be consistent with previous simulation studies, is close to its experimental counterpart provided the TIP4P/Ice model is used to describe the water molecule. Water 201-206 carboxylesterase 2 Homo sapiens 167-170 28960736-1 2017 The crystalline form of methamphetamine, commonly known as crystal meth (crystal methamphetamine) or ICE, is a highly-addictive and powerful stimulant. Methamphetamine 24-39 carboxylesterase 2 Homo sapiens 101-104 28960736-1 2017 The crystalline form of methamphetamine, commonly known as crystal meth (crystal methamphetamine) or ICE, is a highly-addictive and powerful stimulant. crystal methamphetamine 73-96 carboxylesterase 2 Homo sapiens 101-104 28647665-1 2017 DDAB (6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate) is a newly developed near-infrared fluorescent probe for human carboxylesterase 2 (hCE2), exhibiting high specificity and good reactivity for real-time monitoring the enzymatic activities of hCE2 in complex biological systems. 6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate 6-70 carboxylesterase 2 Homo sapiens 135-153 28647665-1 2017 DDAB (6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate) is a newly developed near-infrared fluorescent probe for human carboxylesterase 2 (hCE2), exhibiting high specificity and good reactivity for real-time monitoring the enzymatic activities of hCE2 in complex biological systems. 6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate 6-70 carboxylesterase 2 Homo sapiens 155-159 28647665-1 2017 DDAB (6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate) is a newly developed near-infrared fluorescent probe for human carboxylesterase 2 (hCE2), exhibiting high specificity and good reactivity for real-time monitoring the enzymatic activities of hCE2 in complex biological systems. 6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate 6-70 carboxylesterase 2 Homo sapiens 263-267 28647665-4 2017 Chemical inhibition assays demonstrated that carboxylesterases (CEs) were the major enzymes involved in DDAB hydrolysis in all tested liver microsomes, indicating that DDAB was a selective substrate of CEs in a variety of mammals. 6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate 104-108 carboxylesterase 2 Homo sapiens 45-62 28647665-4 2017 Chemical inhibition assays demonstrated that carboxylesterases (CEs) were the major enzymes involved in DDAB hydrolysis in all tested liver microsomes, indicating that DDAB was a selective substrate of CEs in a variety of mammals. 6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate 168-172 carboxylesterase 2 Homo sapiens 45-62 28647665-5 2017 However, the differential effects of loperamide (LPA, a specific inhibitor against hCE2) on DDAB hydrolysis among various species were observed. Loperamide 37-47 carboxylesterase 2 Homo sapiens 83-87 28647665-5 2017 However, the differential effects of loperamide (LPA, a specific inhibitor against hCE2) on DDAB hydrolysis among various species were observed. Loperamide 49-52 carboxylesterase 2 Homo sapiens 83-87 28647665-5 2017 However, the differential effects of loperamide (LPA, a specific inhibitor against hCE2) on DDAB hydrolysis among various species were observed. 6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate 92-96 carboxylesterase 2 Homo sapiens 83-87 28647665-7 2017 These findings were helpful for the rational use of DDAB as an imaging tool for CE2 in different mammals, as well as for translational researches on the function of mammalian CEs and CE2-associated drug-drug interactions. 6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate 52-56 carboxylesterase 2 Homo sapiens 80-83 28760607-3 2017 The phenolic glucosides and monoterpenoids showed the inhibitory effect against the human carboxylesterase-2 (hCE-2) using a fluorescence bioassay in vitro, with the strongest inhibitor compound 4 (IC50 7.17muM). Glucosides 13-23 carboxylesterase 2 Homo sapiens 90-108 28760607-3 2017 The phenolic glucosides and monoterpenoids showed the inhibitory effect against the human carboxylesterase-2 (hCE-2) using a fluorescence bioassay in vitro, with the strongest inhibitor compound 4 (IC50 7.17muM). Glucosides 13-23 carboxylesterase 2 Homo sapiens 110-115 28760607-3 2017 The phenolic glucosides and monoterpenoids showed the inhibitory effect against the human carboxylesterase-2 (hCE-2) using a fluorescence bioassay in vitro, with the strongest inhibitor compound 4 (IC50 7.17muM). Monoterpenes 28-42 carboxylesterase 2 Homo sapiens 90-108 28760607-3 2017 The phenolic glucosides and monoterpenoids showed the inhibitory effect against the human carboxylesterase-2 (hCE-2) using a fluorescence bioassay in vitro, with the strongest inhibitor compound 4 (IC50 7.17muM). Monoterpenes 28-42 carboxylesterase 2 Homo sapiens 110-115 28218815-2 2017 In silico analysis of carboxylesterases CES1 and CES2 suggested that these enzymes are modified with sialylated N-glycans, which are proposed to stabilize the active multimeric forms of these enzymes. n-glycans 112-121 carboxylesterase 2 Homo sapiens 49-53 28526614-7 2017 Furthermore, over-expression of the fused histidine-tagged ALDH3A1 confers host E. coli cells with enhanced resistance to thermal shock, while ALDH3A1 over-expression in the human corneal cell line HCE-2 was sufficient for protecting them from the cytotoxic effects of both hydrogen peroxide and tert-butyl hydroperoxide. Histidine 42-51 carboxylesterase 2 Homo sapiens 198-203 28218815-6 2017 Azide-modified ManNAc analogues widely used in MGE also enhanced esterase activity and provided a way to enrich targeted glycoengineered proteins (such as CES2), thereby providing unambiguous evidence that the compounds were converted to sialosides and installed into the glycan structures of esterases as intended. Azides 0-5 carboxylesterase 2 Homo sapiens 155-159 28218815-6 2017 Azide-modified ManNAc analogues widely used in MGE also enhanced esterase activity and provided a way to enrich targeted glycoengineered proteins (such as CES2), thereby providing unambiguous evidence that the compounds were converted to sialosides and installed into the glycan structures of esterases as intended. N-acetylmannosamine 15-21 carboxylesterase 2 Homo sapiens 155-159 28218815-6 2017 Azide-modified ManNAc analogues widely used in MGE also enhanced esterase activity and provided a way to enrich targeted glycoengineered proteins (such as CES2), thereby providing unambiguous evidence that the compounds were converted to sialosides and installed into the glycan structures of esterases as intended. sialosides 238-248 carboxylesterase 2 Homo sapiens 155-159 28218815-6 2017 Azide-modified ManNAc analogues widely used in MGE also enhanced esterase activity and provided a way to enrich targeted glycoengineered proteins (such as CES2), thereby providing unambiguous evidence that the compounds were converted to sialosides and installed into the glycan structures of esterases as intended. Polysaccharides 272-278 carboxylesterase 2 Homo sapiens 155-159 28713276-4 2017 Following screening of a series of natural triterpenoids, oleanolic acid (OA), and ursolic acid (UA) were found with strong inhibitory effects on hCE1 and relative high selectivity over hCE2. triterpenoids 43-56 carboxylesterase 2 Homo sapiens 186-190 28713276-4 2017 Following screening of a series of natural triterpenoids, oleanolic acid (OA), and ursolic acid (UA) were found with strong inhibitory effects on hCE1 and relative high selectivity over hCE2. Oleanolic Acid 58-72 carboxylesterase 2 Homo sapiens 186-190 28713276-4 2017 Following screening of a series of natural triterpenoids, oleanolic acid (OA), and ursolic acid (UA) were found with strong inhibitory effects on hCE1 and relative high selectivity over hCE2. Oleanolic Acid 74-76 carboxylesterase 2 Homo sapiens 186-190 28713276-4 2017 Following screening of a series of natural triterpenoids, oleanolic acid (OA), and ursolic acid (UA) were found with strong inhibitory effects on hCE1 and relative high selectivity over hCE2. ursolic acid 83-95 carboxylesterase 2 Homo sapiens 186-190 28713276-4 2017 Following screening of a series of natural triterpenoids, oleanolic acid (OA), and ursolic acid (UA) were found with strong inhibitory effects on hCE1 and relative high selectivity over hCE2. ursolic acid 97-99 carboxylesterase 2 Homo sapiens 186-190 28713276-8 2017 In contrast, the structural modifications on OA and UA at other sites, such as converting the C-3 hydroxy group to 3-O-beta-carboxypropionyl (compounds 20 and 22), led to a dramatically increase of the inhibitory effects against hCE1 and very high selectivity over hCE2. ursolic acid 52-54 carboxylesterase 2 Homo sapiens 265-269 28638342-9 2017 Other polymorphisms in CES2 and ABCB1 were found to be associated with warfarin resistance. Warfarin 71-79 carboxylesterase 2 Homo sapiens 23-27 28242322-2 2017 This study aimed to investigate the inhibitory effects of six commonly used pyrethroids against two major human carboxylesterases (CES) including CES1 and CES2. Pyrethrins 76-87 carboxylesterase 2 Homo sapiens 155-159 28050930-4 2017 The reduction in Tc at the conclusion of precooling was greater in ICE (-0.9 +- 0.3 C) compared with CON (-0.2 +- 0.2 C) (p <= .05). Technetium 17-19 carboxylesterase 2 Homo sapiens 67-70 28285137-9 2017 CES2A1 mRNA and protein levels in human iPS cell-derived enterocytes were comparable to Caco-2 cells, whereas CES1A levels were lower in human iPS cell-derived enterocytes compared with Caco-2 cells. IPS 40-43 carboxylesterase 2 Homo sapiens 0-6 28285137-10 2017 p-nitrophenyl acetate hydrolysis in human iPS cell-derived enterocytes was significantly inhibited by the CES2A1-specific inhibitor telmisartan. 4-nitrophenyl acetate 0-21 carboxylesterase 2 Homo sapiens 106-112 28285137-10 2017 p-nitrophenyl acetate hydrolysis in human iPS cell-derived enterocytes was significantly inhibited by the CES2A1-specific inhibitor telmisartan. IPS 42-45 carboxylesterase 2 Homo sapiens 106-112 28285137-10 2017 p-nitrophenyl acetate hydrolysis in human iPS cell-derived enterocytes was significantly inhibited by the CES2A1-specific inhibitor telmisartan. Telmisartan 132-143 carboxylesterase 2 Homo sapiens 106-112 28285137-11 2017 Hydrolysis levels of the CES2A1-specific substrate aspirin were similar in human iPS cell-derived enterocytes and Caco-2 cells, whereas hydrolysis of the CES1A-specific substrate monoethylglycylxylidine was observed in Caco-2 cells but not in human iPS cell-derived enterocytes. Aspirin 51-58 carboxylesterase 2 Homo sapiens 25-31 28285137-11 2017 Hydrolysis levels of the CES2A1-specific substrate aspirin were similar in human iPS cell-derived enterocytes and Caco-2 cells, whereas hydrolysis of the CES1A-specific substrate monoethylglycylxylidine was observed in Caco-2 cells but not in human iPS cell-derived enterocytes. IPS 81-84 carboxylesterase 2 Homo sapiens 25-31 28126414-3 2017 hCE1 is known to play crucial roles in the metabolism of a wide variety of endogenous esters, clinical drugs and insecticides, while hCE2 plays a key role in the metabolic activation of anticancer agents including irinotecan and capecitabine. Irinotecan 214-224 carboxylesterase 2 Homo sapiens 133-137 27709788-3 2017 Ice often contains impurities, such as salts, and in such cases, a liquid phase coexists with solid ice over a wide temperature range. Salts 39-44 carboxylesterase 2 Homo sapiens 0-3 28288513-0 2017 Dielectric Relaxation of Ice in Gelatin-Water Mixtures. Water 40-45 carboxylesterase 2 Homo sapiens 25-28 28126414-3 2017 hCE1 is known to play crucial roles in the metabolism of a wide variety of endogenous esters, clinical drugs and insecticides, while hCE2 plays a key role in the metabolic activation of anticancer agents including irinotecan and capecitabine. Capecitabine 229-241 carboxylesterase 2 Homo sapiens 133-137 28151687-0 2017 Transient Phase of Ice Observed by Sum Frequency Generation at the Water/Mineral Interface During Freezing. Water 67-72 carboxylesterase 2 Homo sapiens 19-22 28641501-0 2017 Hematological Characterizations and Molecular Diagnostic Aspects of Hb Wiangpapao [alpha44(CE2)Pro Ser (alpha1), CCG>TCG; HBA1: c.133C>T], a New alpha-Globin Variant Found in a Pregnant Thai Woman. Serine 99-102 carboxylesterase 2 Homo sapiens 91-94 28641501-1 2017 We report the hematological parameters and provide a rapid molecular analysis method for detection of Hb Wiangpapao [alpha44(CE2)Pro Ser, CCG>TCG; HBA1: c.133C>T], a new alpha-globin variant found in a pregnant Thai woman. Serine 133-136 carboxylesterase 2 Homo sapiens 125-128 27965153-0 2017 Covalent inhibition of carboxylesterase-2 by sofosbuvir and its effect on the hydrolytic activation of tenofovir disoproxil. Sofosbuvir 45-55 carboxylesterase 2 Homo sapiens 23-41 27965153-0 2017 Covalent inhibition of carboxylesterase-2 by sofosbuvir and its effect on the hydrolytic activation of tenofovir disoproxil. Tenofovir 103-123 carboxylesterase 2 Homo sapiens 23-41 28075505-1 2017 The reactivity of terminal uranium(V/VI) nitrides with CE2 (E=O, S) is presented. Uranium 27-34 carboxylesterase 2 Homo sapiens 55-58 28075505-1 2017 The reactivity of terminal uranium(V/VI) nitrides with CE2 (E=O, S) is presented. nitrides 41-49 carboxylesterase 2 Homo sapiens 55-58 28075505-5 2017 Calculated reaction profiles reveal outer-sphere reactivity for uranium(V) but inner-sphere mechanisms for uranium(VI); despite the wide divergence of products the initial activation of CE2 follows mechanistically related pathways, providing insight into the factors of uranium oxidation state, chalcogen, and NCE groups that govern the subsequent divergent redox reactions that include common one-electron reactions and a less-common two-electron redox event. Uranium 107-114 carboxylesterase 2 Homo sapiens 186-189 28075505-5 2017 Calculated reaction profiles reveal outer-sphere reactivity for uranium(V) but inner-sphere mechanisms for uranium(VI); despite the wide divergence of products the initial activation of CE2 follows mechanistically related pathways, providing insight into the factors of uranium oxidation state, chalcogen, and NCE groups that govern the subsequent divergent redox reactions that include common one-electron reactions and a less-common two-electron redox event. Uranium 107-114 carboxylesterase 2 Homo sapiens 186-189 28151687-3 2017 Since the most stable form of ice, hexagonal and cubic ice, are centrosymmetric, our study suggests the transient existence of stacking-disordered ice during the freezing process at water/mineral interfaces. Water 182-187 carboxylesterase 2 Homo sapiens 55-58 28151687-3 2017 Since the most stable form of ice, hexagonal and cubic ice, are centrosymmetric, our study suggests the transient existence of stacking-disordered ice during the freezing process at water/mineral interfaces. Water 182-187 carboxylesterase 2 Homo sapiens 55-58 28151687-1 2017 We observed a transient noncentrosymmetric phase of ice at water/mineral interfaces during freezing, which enhanced the intensity of the IR-visible sum frequency generation intensity by up to 20-fold. Water 59-64 carboxylesterase 2 Homo sapiens 52-55 28151687-3 2017 Since the most stable form of ice, hexagonal and cubic ice, are centrosymmetric, our study suggests the transient existence of stacking-disordered ice during the freezing process at water/mineral interfaces. Water 182-187 carboxylesterase 2 Homo sapiens 30-33 28114917-13 2017 In addition, total CES2.0 scores were negatively correlated with the PHQ-9 (r = -0.22) and BGQ (r = -0.10). (r)-butane-1,2,4-triol 91-94 carboxylesterase 2 Homo sapiens 19-23 27895113-0 2017 Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants. Oseltamivir 134-145 carboxylesterase 2 Homo sapiens 72-76 27895113-1 2017 The age-dependent absolute protein abundance of carboxylesterase (CES) 1 and CES2 in human liver was investigated and applied to predict infant pharmacokinetics (PK) of oseltamivir. Oseltamivir 169-180 carboxylesterase 2 Homo sapiens 77-81 28099843-0 2017 Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance. Diglycerides 50-64 carboxylesterase 2 Homo sapiens 6-24 28044168-1 2017 Photoinduced electron transfer (ET) in Mo2 dimers, [Mo2(DAniF)3]2(mu-E2C(ph)CE2) (DAniF = N,N"-di(p-anisyl)formamidinate, E = O or S), has been studied by femtosecond transient spectral techniques. n,n"-di(p-anisyl)formamidinate 90-120 carboxylesterase 2 Homo sapiens 76-79 28099843-0 2017 Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance. Glucose 82-89 carboxylesterase 2 Homo sapiens 6-24 28099843-5 2017 In mice, obesity reduced CES2, whereas adenoviral delivery of human CES2 reversed hepatic steatosis, improved glucose tolerance, and decreased inflammation. Glucose 110-117 carboxylesterase 2 Homo sapiens 68-72 28099843-7 2017 CES2 possesses triglyceride and diacylglycerol lipase activities and displayed an inverse correlation with HOMA-IR and hepatic diacylglycerol concentrations in humans. Triglycerides 15-27 carboxylesterase 2 Homo sapiens 0-4 28099843-7 2017 CES2 possesses triglyceride and diacylglycerol lipase activities and displayed an inverse correlation with HOMA-IR and hepatic diacylglycerol concentrations in humans. Diglycerides 32-46 carboxylesterase 2 Homo sapiens 0-4 28208865-4 2016 The patient was administered 3-cycles of neo-adjuvant chemotherapy with ifosphamide, carboplatin and etoposide (ICE-chemotherapy) and subsequently 3 more cycles of chemotherapy post surgery, followed by radiation. Etoposide 101-110 carboxylesterase 2 Homo sapiens 112-115 27702666-2 2016 This study aimed to investigate the inhibitory effects of ethanol extract from WMR against human carboxylesterase 2 (hCE2), as well as to identity and character natural hCE2 inhibitors in this herbal. Ethanol 58-65 carboxylesterase 2 Homo sapiens 97-115 27702666-2 2016 This study aimed to investigate the inhibitory effects of ethanol extract from WMR against human carboxylesterase 2 (hCE2), as well as to identity and character natural hCE2 inhibitors in this herbal. Ethanol 58-65 carboxylesterase 2 Homo sapiens 117-121 27702666-3 2016 Our results demonstrated that the ethanol extract of WMR displayed potent inhibitory effects against hCE2, while three major bioactive constitutes in WMR were identified on the basis of LC fingerprinting combined with activity-based screening of LC fractions. Ethanol 34-41 carboxylesterase 2 Homo sapiens 101-105 27974431-0 2017 BET 2: Ice water immersion, other vagal manoeuvres or adenosine for SVT in children. Water 11-16 carboxylesterase 2 Homo sapiens 7-10 27974431-7 2017 This best evidence shows that ice water to the face appears to be a safe, quick, effective and non-invasive treatment for paediatric SVT. Water 34-39 carboxylesterase 2 Homo sapiens 30-33 27936336-0 2017 Experiences of Health Professionals Caring for People Presenting to the Emergency Department After Taking Crystal Methamphetamine ("ICE"). Methamphetamine 114-129 carboxylesterase 2 Homo sapiens 132-136 27936336-1 2017 Globally, addiction to "ICE" (crystal methamphetamine) is increasing and presents emergency health care services personnel with a number of challenges. crystal methamphetamine 30-53 carboxylesterase 2 Homo sapiens 23-28 28028745-0 2017 Hexagonal ice in pure water and biological NMR samples. Water 22-27 carboxylesterase 2 Homo sapiens 10-13 28028745-2 2017 We characterize its spectroscopic behavior in the temperature range from 100 to 273 K, and find that it behaves like pure water ice. Water 122-127 carboxylesterase 2 Homo sapiens 128-131 28799362-13 2016 A maximum in the compressibility was found for the TIP4P/ICE model in supercooled water. Water 82-87 carboxylesterase 2 Homo sapiens 57-60 26750665-9 2016 Furthermore, the ERK and p38 MAPK pathways were involved in the GA-mediated down-regulation of CES1 and CES2. gambogic acid 64-66 carboxylesterase 2 Homo sapiens 104-108 27159062-2 2016 MATERIALS AND METHODS: A chemical burn was induced using 0.1 M NaOH in both adenovirus 12-SV40 hybrid-transformed human corneal epithelial (HCE-2) cells and C57BL/6 mice. Sodium Hydroxide 63-67 carboxylesterase 2 Homo sapiens 140-145 27159062-4 2016 The viability of the HCE-2 cells was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. thiazolyl blue 56-116 carboxylesterase 2 Homo sapiens 21-26 27540626-4 2016 Like other clathrate hydrates and forms of ice, the protons of H2O molecules within C0 are disordered. Water 63-66 carboxylesterase 2 Homo sapiens 43-46 27329304-8 2016 Carboxylesterase 2 (CE2) selectively catalyzed the deacetylation of AKBA to form KBA. 11-keto-boswellic acid 69-72 carboxylesterase 2 Homo sapiens 0-18 27329304-8 2016 Carboxylesterase 2 (CE2) selectively catalyzed the deacetylation of AKBA to form KBA. 11-keto-boswellic acid 69-72 carboxylesterase 2 Homo sapiens 20-23 27614009-1 2016 The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). Dabigatran 31-51 carboxylesterase 2 Homo sapiens 101-119 27614009-1 2016 The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). Dabigatran 31-51 carboxylesterase 2 Homo sapiens 121-125 27614009-1 2016 The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). Dabigatran 53-57 carboxylesterase 2 Homo sapiens 101-119 27614009-1 2016 The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). Dabigatran 53-57 carboxylesterase 2 Homo sapiens 121-125 27614009-1 2016 The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). Dabigatran 31-41 carboxylesterase 2 Homo sapiens 101-119 27614009-1 2016 The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). Dabigatran 31-41 carboxylesterase 2 Homo sapiens 121-125 27614009-1 2016 The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). Dabigatran 53-56 carboxylesterase 2 Homo sapiens 101-119 27614009-1 2016 The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). Dabigatran 53-56 carboxylesterase 2 Homo sapiens 121-125 27569869-4 2016 Capecitabine is activated to 5-FU by CES, CDA and TYMP, of which SNPs in CDA and CES2 were found to be associated with efficacy and toxicity. Capecitabine 0-12 carboxylesterase 2 Homo sapiens 81-85 27569869-4 2016 Capecitabine is activated to 5-FU by CES, CDA and TYMP, of which SNPs in CDA and CES2 were found to be associated with efficacy and toxicity. Fluorouracil 29-33 carboxylesterase 2 Homo sapiens 81-85 27569869-4 2016 Capecitabine is activated to 5-FU by CES, CDA and TYMP, of which SNPs in CDA and CES2 were found to be associated with efficacy and toxicity. Cerium 37-40 carboxylesterase 2 Homo sapiens 81-85 27454346-7 2016 Recombinant hCE2 and mfCES2v3 showed similar Km values for both enantiomers of all propranolol derivatives tested. Propranolol 83-94 carboxylesterase 2 Homo sapiens 12-16 27454346-8 2016 However, recombinant mfCES2v3 showed extreme R-enantioselective hydrolysis, and both hCE2 and mfCES2v3 showed lower activity for O-3-methyl-n-butyryl propranolol than for O-n-valeryl and O-2-methyl-n-butyryl propranolol. o-3-methyl-n-butyryl propranolol 129-161 carboxylesterase 2 Homo sapiens 85-89 27454346-8 2016 However, recombinant mfCES2v3 showed extreme R-enantioselective hydrolysis, and both hCE2 and mfCES2v3 showed lower activity for O-3-methyl-n-butyryl propranolol than for O-n-valeryl and O-2-methyl-n-butyryl propranolol. o-n-valeryl 171-182 carboxylesterase 2 Homo sapiens 85-89 27454346-8 2016 However, recombinant mfCES2v3 showed extreme R-enantioselective hydrolysis, and both hCE2 and mfCES2v3 showed lower activity for O-3-methyl-n-butyryl propranolol than for O-n-valeryl and O-2-methyl-n-butyryl propranolol. o-2-methyl-n-butyryl propranolol 187-219 carboxylesterase 2 Homo sapiens 85-89 27454346-10 2016 Docking simulations of the protein-ligand complex demonstrated that the enantioselectivity of mfCES2v3 for propranolol derivatives was possibly caused by the orientation of its active site being deformed by an amino acid change of Leu107 to Gln107 and the insertion of Met309, compared with hCE2. Propranolol 107-118 carboxylesterase 2 Homo sapiens 291-295 26750665-7 2016 Moreover, the GA-mediated repression of CES2 attenuated CPT-11-induced apoptosis. gambogic acid 14-16 carboxylesterase 2 Homo sapiens 40-44 26750665-7 2016 Moreover, the GA-mediated repression of CES2 attenuated CPT-11-induced apoptosis. Irinotecan 56-62 carboxylesterase 2 Homo sapiens 40-44 26750665-11 2016 Taken together, our data suggest that GA is a potent repressor of CES1 and CES2 and that combination with GA will affect the metabolism of drugs containing ester bonds. gambogic acid 38-40 carboxylesterase 2 Homo sapiens 75-79 26750665-11 2016 Taken together, our data suggest that GA is a potent repressor of CES1 and CES2 and that combination with GA will affect the metabolism of drugs containing ester bonds. Esters 156-161 carboxylesterase 2 Homo sapiens 75-79 27410458-0 2016 Rate of Homogenous Nucleation of Ice in Supercooled Water. Water 52-57 carboxylesterase 2 Homo sapiens 33-36 27224254-7 2016 Because CocE and its mutants are all active against cocaine and inactive against benzoylecgonine, one might simply assume that other enzymes that are active against cocaine are also inactive against benzoylecgonine. Cocaine 52-59 carboxylesterase 2 Homo sapiens 8-12 27224254-7 2016 Because CocE and its mutants are all active against cocaine and inactive against benzoylecgonine, one might simply assume that other enzymes that are active against cocaine are also inactive against benzoylecgonine. benzoylecgonine 81-96 carboxylesterase 2 Homo sapiens 8-12 27224254-7 2016 Because CocE and its mutants are all active against cocaine and inactive against benzoylecgonine, one might simply assume that other enzymes that are active against cocaine are also inactive against benzoylecgonine. Cocaine 165-172 carboxylesterase 2 Homo sapiens 8-12 27224254-7 2016 Because CocE and its mutants are all active against cocaine and inactive against benzoylecgonine, one might simply assume that other enzymes that are active against cocaine are also inactive against benzoylecgonine. benzoylecgonine 199-214 carboxylesterase 2 Homo sapiens 8-12 27130352-13 2016 CES1 inhibition (troglitazone) was greater than CES2 (loperamide), suggesting a primary metabolic role for CES1. Loperamide 54-64 carboxylesterase 2 Homo sapiens 48-52 27149931-1 2016 Carboxylesterase 2 (CES-2) is instrumental for conversion of ester-containing prodrugs in cancer treatment. Esters 8-13 carboxylesterase 2 Homo sapiens 20-25 27149931-8 2016 In summary, the conversion of ester-containing prodrugs by CES-2 is mainly to occur in the periphery, during liver passage and in the colon after enterohepatic recirculation. Esters 30-35 carboxylesterase 2 Homo sapiens 59-64 29910286-7 2016 Rating of perceived exertion was also lower with ICE following HEX2 (vs. CON) and after RI2 (vs. SPRAY). ri2 88-91 carboxylesterase 2 Homo sapiens 49-52 27337172-1 2016 A newly designed electron donor-acceptor conjugate, namely Ce2@Ih-C80-H2P consisting of an endohedral dimetallofullerene Ce2@Ih-C80 and a free-base prophyrin (H2P), has been synthesized and systematically investigated. dimetallofullerene 102-120 carboxylesterase 2 Homo sapiens 59-62 27337172-1 2016 A newly designed electron donor-acceptor conjugate, namely Ce2@Ih-C80-H2P consisting of an endohedral dimetallofullerene Ce2@Ih-C80 and a free-base prophyrin (H2P), has been synthesized and systematically investigated. dimetallofullerene 102-120 carboxylesterase 2 Homo sapiens 121-124 27337172-1 2016 A newly designed electron donor-acceptor conjugate, namely Ce2@Ih-C80-H2P consisting of an endohedral dimetallofullerene Ce2@Ih-C80 and a free-base prophyrin (H2P), has been synthesized and systematically investigated. prophyrin 148-157 carboxylesterase 2 Homo sapiens 59-62 27337172-1 2016 A newly designed electron donor-acceptor conjugate, namely Ce2@Ih-C80-H2P consisting of an endohedral dimetallofullerene Ce2@Ih-C80 and a free-base prophyrin (H2P), has been synthesized and systematically investigated. 1-deoxygluco-heptulose 2-phosphate 70-73 carboxylesterase 2 Homo sapiens 59-62 27337172-1 2016 A newly designed electron donor-acceptor conjugate, namely Ce2@Ih-C80-H2P consisting of an endohedral dimetallofullerene Ce2@Ih-C80 and a free-base prophyrin (H2P), has been synthesized and systematically investigated. 1-deoxygluco-heptulose 2-phosphate 70-73 carboxylesterase 2 Homo sapiens 121-124 26825642-1 2016 Human hepatic carboxylesterase 1 and 2 (CES1 and CES2) are important for the disposition of ester- and amide-bond-containing pharmaceuticals and environmental chemicals. Esters 22-27 carboxylesterase 2 Homo sapiens 49-53 26825642-1 2016 Human hepatic carboxylesterase 1 and 2 (CES1 and CES2) are important for the disposition of ester- and amide-bond-containing pharmaceuticals and environmental chemicals. Amides 103-108 carboxylesterase 2 Homo sapiens 49-53 26900660-0 2016 Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2. Glycyrrhetinic Acid 64-83 carboxylesterase 2 Homo sapiens 145-163 26856340-5 2016 Graphical Abstract Ce2(TPP)3 sandwich complex application as a fluorescent probe for measuring trace amounts of mercury and copper in real samples. Mercury 112-119 carboxylesterase 2 Homo sapiens 19-28 26856340-5 2016 Graphical Abstract Ce2(TPP)3 sandwich complex application as a fluorescent probe for measuring trace amounts of mercury and copper in real samples. Copper 124-130 carboxylesterase 2 Homo sapiens 19-28 26900660-2 2016 In this study, 18beta-glycyrrhetinic acid (GA), the most abundant pentacyclic triterpenoid from natural source, was selected as a reference compound for the development of potent and specific inhibitors against hCE2. 18alpha-glycyrrhetinic acid 15-41 carboxylesterase 2 Homo sapiens 211-215 26983558-1 2016 Crystallization of ice from deeply supercooled water and amorphous ices - a process of fundamental importance in the atmosphere, interstellar space, and cryobiology - results in stacking disordered ices with a wide range of metastabilities with respect to hexagonal ice. Water 47-52 carboxylesterase 2 Homo sapiens 19-22 26983558-3 2016 Here we use molecular dynamics simulations with the mW water model to characterize the structure of ice freshly grown from supercooled water at temperatures from 210 to 270 K, the thermodynamics of stacking faults, line defects, and interfaces, and to elucidate the interplay between kinetics and thermodynamics in determining the structure of ice. Water 135-140 carboxylesterase 2 Homo sapiens 100-103 26983558-7 2016 The free energy cost for creating a pair of cubic layers in ice is 8.0 J mol(-1) in experiments, and 9.7 +- 1.9 J mol(-1) for the mW water model. Water 133-138 carboxylesterase 2 Homo sapiens 60-63 26900660-2 2016 In this study, 18beta-glycyrrhetinic acid (GA), the most abundant pentacyclic triterpenoid from natural source, was selected as a reference compound for the development of potent and specific inhibitors against hCE2. 18alpha-glycyrrhetinic acid 43-45 carboxylesterase 2 Homo sapiens 211-215 26900660-5 2016 Converting the 11-oxo-12-ene of GA to 12-diene moiety, and C-3 hydroxyl and C-30 carboxyl group to 3-O-beta-carboxypropionyl and ethyl ester respectively, led to a significant enhancement of the inhibitory effect on hCE2 and the selectivity over hCE1. 11-oxo-12-ene 15-28 carboxylesterase 2 Homo sapiens 216-220 26900660-5 2016 Converting the 11-oxo-12-ene of GA to 12-diene moiety, and C-3 hydroxyl and C-30 carboxyl group to 3-O-beta-carboxypropionyl and ethyl ester respectively, led to a significant enhancement of the inhibitory effect on hCE2 and the selectivity over hCE1. 18alpha-glycyrrhetinic acid 32-34 carboxylesterase 2 Homo sapiens 216-220 26900660-1 2016 Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the human intestine and various tumour tissues, plays important roles in the oral bioavailability and treatment outcomes of ester- or amide-containing drugs or prodrugs, such as anticancer agents CPT-11 (irinotecan) and LY2334737 (gemcitabine). Esters 14-19 carboxylesterase 2 Homo sapiens 26-30 26900660-1 2016 Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the human intestine and various tumour tissues, plays important roles in the oral bioavailability and treatment outcomes of ester- or amide-containing drugs or prodrugs, such as anticancer agents CPT-11 (irinotecan) and LY2334737 (gemcitabine). Amides 205-210 carboxylesterase 2 Homo sapiens 6-24 26900660-5 2016 Converting the 11-oxo-12-ene of GA to 12-diene moiety, and C-3 hydroxyl and C-30 carboxyl group to 3-O-beta-carboxypropionyl and ethyl ester respectively, led to a significant enhancement of the inhibitory effect on hCE2 and the selectivity over hCE1. ethyl ester 129-140 carboxylesterase 2 Homo sapiens 216-220 26900660-1 2016 Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the human intestine and various tumour tissues, plays important roles in the oral bioavailability and treatment outcomes of ester- or amide-containing drugs or prodrugs, such as anticancer agents CPT-11 (irinotecan) and LY2334737 (gemcitabine). Amides 205-210 carboxylesterase 2 Homo sapiens 26-30 26900660-1 2016 Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the human intestine and various tumour tissues, plays important roles in the oral bioavailability and treatment outcomes of ester- or amide-containing drugs or prodrugs, such as anticancer agents CPT-11 (irinotecan) and LY2334737 (gemcitabine). Irinotecan 267-273 carboxylesterase 2 Homo sapiens 6-24 26900660-1 2016 Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the human intestine and various tumour tissues, plays important roles in the oral bioavailability and treatment outcomes of ester- or amide-containing drugs or prodrugs, such as anticancer agents CPT-11 (irinotecan) and LY2334737 (gemcitabine). Irinotecan 267-273 carboxylesterase 2 Homo sapiens 26-30 26900660-1 2016 Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the human intestine and various tumour tissues, plays important roles in the oral bioavailability and treatment outcomes of ester- or amide-containing drugs or prodrugs, such as anticancer agents CPT-11 (irinotecan) and LY2334737 (gemcitabine). Irinotecan 275-285 carboxylesterase 2 Homo sapiens 6-24 26900660-1 2016 Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the human intestine and various tumour tissues, plays important roles in the oral bioavailability and treatment outcomes of ester- or amide-containing drugs or prodrugs, such as anticancer agents CPT-11 (irinotecan) and LY2334737 (gemcitabine). Irinotecan 275-285 carboxylesterase 2 Homo sapiens 26-30 26900660-1 2016 Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the human intestine and various tumour tissues, plays important roles in the oral bioavailability and treatment outcomes of ester- or amide-containing drugs or prodrugs, such as anticancer agents CPT-11 (irinotecan) and LY2334737 (gemcitabine). LY2334737 291-300 carboxylesterase 2 Homo sapiens 6-24 26900660-1 2016 Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the human intestine and various tumour tissues, plays important roles in the oral bioavailability and treatment outcomes of ester- or amide-containing drugs or prodrugs, such as anticancer agents CPT-11 (irinotecan) and LY2334737 (gemcitabine). LY2334737 291-300 carboxylesterase 2 Homo sapiens 26-30 26900660-1 2016 Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the human intestine and various tumour tissues, plays important roles in the oral bioavailability and treatment outcomes of ester- or amide-containing drugs or prodrugs, such as anticancer agents CPT-11 (irinotecan) and LY2334737 (gemcitabine). gemcitabine 302-313 carboxylesterase 2 Homo sapiens 6-24 26900660-1 2016 Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the human intestine and various tumour tissues, plays important roles in the oral bioavailability and treatment outcomes of ester- or amide-containing drugs or prodrugs, such as anticancer agents CPT-11 (irinotecan) and LY2334737 (gemcitabine). gemcitabine 302-313 carboxylesterase 2 Homo sapiens 26-30 26817948-8 2016 Further incubation studies with recombinant human CES1 and carboxylesterase 2 confirmed that sacubitril is a selective CES1 substrate. sacubitril and valsartan sodium hydrate drug combination 93-103 carboxylesterase 2 Homo sapiens 59-77 28250715-5 2016 This finding for CocH-catalyzed hydrolysis of (+)-cocaine is remarkably different from that for the (+)-cocaine hydrolysis catalyzed by bacterial cocaine esterase in which the first reaction step of the deacylation is associated with the highest free energy barrier (~17.9 kcal/mol). Cocaine 46-57 carboxylesterase 2 Homo sapiens 146-162 26718653-6 2016 Recombinant human AADAC was shown to catalyze prasugrel hydrolysis with a CLint value of 50.0 +- 1.2 ml/min/mg protein with a similar Km value to human intestinal and liver microsomes, whereas the CLint values of human CES1 and CES2 were 4.6 +- 0.1 and 6.6 +- 0.3 ml/min/mg protein, respectively. Prasugrel Hydrochloride 46-55 carboxylesterase 2 Homo sapiens 228-232 26558823-8 2016 In conclusion, another protein capable of hydrolyzing prasugrel to its thiolactone metabolite was identified as RKIP, and this protein may play a significant role with hCE2 in prasugrel bioactivation in human intestine. Thiolactone 71-82 carboxylesterase 2 Homo sapiens 168-172 26937657-0 2016 "Ice" (crystal methamphetamine): concerns and responses. Methamphetamine 15-30 carboxylesterase 2 Homo sapiens 1-5 26558823-1 2016 Prasugrel is a thienopyridine antiplatelet prodrug that undergoes rapid hydrolysis in vivo to a thiolactone metabolite by human carboxylesterase-2 (hCE2) during gastrointestinal absorption. Prasugrel Hydrochloride 0-9 carboxylesterase 2 Homo sapiens 128-146 26558823-1 2016 Prasugrel is a thienopyridine antiplatelet prodrug that undergoes rapid hydrolysis in vivo to a thiolactone metabolite by human carboxylesterase-2 (hCE2) during gastrointestinal absorption. Prasugrel Hydrochloride 0-9 carboxylesterase 2 Homo sapiens 148-152 26558823-1 2016 Prasugrel is a thienopyridine antiplatelet prodrug that undergoes rapid hydrolysis in vivo to a thiolactone metabolite by human carboxylesterase-2 (hCE2) during gastrointestinal absorption. thienopyridine 15-29 carboxylesterase 2 Homo sapiens 128-146 26558823-1 2016 Prasugrel is a thienopyridine antiplatelet prodrug that undergoes rapid hydrolysis in vivo to a thiolactone metabolite by human carboxylesterase-2 (hCE2) during gastrointestinal absorption. thienopyridine 15-29 carboxylesterase 2 Homo sapiens 148-152 26558823-1 2016 Prasugrel is a thienopyridine antiplatelet prodrug that undergoes rapid hydrolysis in vivo to a thiolactone metabolite by human carboxylesterase-2 (hCE2) during gastrointestinal absorption. Thiolactone 96-107 carboxylesterase 2 Homo sapiens 128-146 26558823-1 2016 Prasugrel is a thienopyridine antiplatelet prodrug that undergoes rapid hydrolysis in vivo to a thiolactone metabolite by human carboxylesterase-2 (hCE2) during gastrointestinal absorption. Thiolactone 96-107 carboxylesterase 2 Homo sapiens 148-152 26558823-4 2016 Using size-exclusion column chromatography of a human small intestinal S9 fraction, another peak besides the hCE2 peak was observed to have prasugrel hydrolyzing activity, and this protein was found to have a molecular weight of about 20 kDa. Prasugrel Hydrochloride 140-149 carboxylesterase 2 Homo sapiens 109-113 26558823-6 2016 Second, we evaluated the enzymatic kinetic parameters for prasugrel hydrolysis using recombinant human RKIP and hCE2 and estimated the contributions of these two hydrolyzing enzymes to the prasugrel hydrolysis reaction in human intestine, which were approximately 40% for hRKIP and 60% for hCE2. Prasugrel Hydrochloride 58-67 carboxylesterase 2 Homo sapiens 112-116 27951723-10 2016 The patient underwent another surgery and then received 10 cycles of second-line chemotherapy in the ICE (ifosfamide, carboplatin, and etoposide) regimen. Ifosfamide 106-116 carboxylesterase 2 Homo sapiens 101-104 28250715-5 2016 This finding for CocH-catalyzed hydrolysis of (+)-cocaine is remarkably different from that for the (+)-cocaine hydrolysis catalyzed by bacterial cocaine esterase in which the first reaction step of the deacylation is associated with the highest free energy barrier (~17.9 kcal/mol). Cocaine 100-111 carboxylesterase 2 Homo sapiens 146-162 26374553-2 2015 The aim of this study was to assess the efficacy and safety of ifosfamide in combination with carboplatin and etoposide (ICE) in previously untreated patients with SCLC. Ifosfamide 63-73 carboxylesterase 2 Homo sapiens 121-124 26340669-0 2016 Fluoxetine reduces CES1, CES2, and CYP3A4 expression through decreasing PXR and increasing DEC1 in HepG2 cells. Fluoxetine 0-10 carboxylesterase 2 Homo sapiens 25-29 26340669-12 2016 Knockdown of DEC1 alone increased the expression of PXR and CYP3A4 and almost abolished the decreases of CES1, CES2, and CYP3A4 induced by FLX. Fluoxetine 139-142 carboxylesterase 2 Homo sapiens 111-115 26641926-2 2015 Upon addition of hCE2, the probe could be readily hydrolyzed to release 4-amino-1,8-naphthalimide (NAH), which brings remarkable red-shift in fluorescence (90 nm) spectrum. 4-amino-1,8-naphthalimide 72-97 carboxylesterase 2 Homo sapiens 17-21 26641926-2 2015 Upon addition of hCE2, the probe could be readily hydrolyzed to release 4-amino-1,8-naphthalimide (NAH), which brings remarkable red-shift in fluorescence (90 nm) spectrum. 4-amino-1,8-naphthalimide 99-102 carboxylesterase 2 Homo sapiens 17-21 26408002-4 2015 By using human liver microsomes (HLM) or intestinal microsomes and recombinant enzymes, we found that diacetolol was produced via hydrolysis by carboxylesterase 2 (CES2) and subsequent acetylation by N-acetyltransferase 2 (NAT2). diacetolol 102-112 carboxylesterase 2 Homo sapiens 144-162 26408002-4 2015 By using human liver microsomes (HLM) or intestinal microsomes and recombinant enzymes, we found that diacetolol was produced via hydrolysis by carboxylesterase 2 (CES2) and subsequent acetylation by N-acetyltransferase 2 (NAT2). diacetolol 102-112 carboxylesterase 2 Homo sapiens 164-168 26511073-0 2015 Dynamics of Ice/Water Confined in Nanoporous Alumina. Aluminum Oxide 45-52 carboxylesterase 2 Homo sapiens 12-15 26511073-1 2015 Dielectric (DS), IR spectroscopy, and (1)H MAS NMR are employed in the study of ice/water confined in nanoporous alumina with pore diameters ranging from 400 nm down to 25 nm. Aluminum Oxide 113-120 carboxylesterase 2 Homo sapiens 80-83 26511073-2 2015 Within nanoporous alumina there is a transformation from heterogeneous nucleation of hexagonal ice in the larger pores to homogeneous nucleation of cubic ice in the smaller pores. Aluminum Oxide 18-25 carboxylesterase 2 Homo sapiens 95-98 26511073-2 2015 Within nanoporous alumina there is a transformation from heterogeneous nucleation of hexagonal ice in the larger pores to homogeneous nucleation of cubic ice in the smaller pores. Aluminum Oxide 18-25 carboxylesterase 2 Homo sapiens 154-157 26511073-5 2015 The "fast" and "slow" processes with an Arrhenius temperature dependence are attributed to ice and supercooled water relaxation, respectively. Water 111-116 carboxylesterase 2 Homo sapiens 91-94 26321725-8 2015 Human CES1 and CES2 isozymes expressed in COS cells both readily hydrolyzed phenyl salicylate, but the activity of CES2 was higher than that of CES1. phenyl salicylate 76-93 carboxylesterase 2 Homo sapiens 15-19 28955811-3 2016 The present work evaluated the involvement of glycans in hCES2 activity and thermo stability in an attempt to find alternative active forms of the enzyme that might be adequate for structure elucidation. Polysaccharides 46-53 carboxylesterase 2 Homo sapiens 57-62 28955811-4 2016 Partial or non-glycosylated forms of a secreted form of hCES2 have been obtained by three approaches: (i) enzymatic deglycosylation with peptide N-glycosidase F; (ii) incubation with the inhibitor tunicamycin; ii) site directed mutagenesis of each or both N-glycosylation sites. Tunicamycin 197-208 carboxylesterase 2 Homo sapiens 56-61 28955811-4 2016 Partial or non-glycosylated forms of a secreted form of hCES2 have been obtained by three approaches: (i) enzymatic deglycosylation with peptide N-glycosidase F; (ii) incubation with the inhibitor tunicamycin; ii) site directed mutagenesis of each or both N-glycosylation sites. Nitrogen 145-146 carboxylesterase 2 Homo sapiens 56-61 28955811-6 2016 On the other hand, tunicamycin led to decreased levels of secreted hCES2 but the enzyme was still active. Tunicamycin 19-30 carboxylesterase 2 Homo sapiens 67-72 28955811-7 2016 In agreement, mutation of each and both N-glycosylation sites led to decreased levels of secreted active hCES2. Nitrogen 40-41 carboxylesterase 2 Homo sapiens 105-110 26374553-2 2015 The aim of this study was to assess the efficacy and safety of ifosfamide in combination with carboplatin and etoposide (ICE) in previously untreated patients with SCLC. Etoposide 110-119 carboxylesterase 2 Homo sapiens 121-124 26509550-0 2015 Effect of Cellular Location of Human Carboxylesterase 2 on CPT-11 Hydrolysis and Anticancer Activity. Irinotecan 59-65 carboxylesterase 2 Homo sapiens 37-55 26451632-0 2015 Reply to "Comment on "Photolysis of Polycyclic Aromatic Hydrocarbons on Water and Ice Surfaces" and on "Nonchromophoric Organic Matter Suppresses Polycyclic Aromatic Hydrocarbon Photolysis in Ice and at Ice Surfaces"". Polycyclic Aromatic Hydrocarbons 36-68 carboxylesterase 2 Homo sapiens 82-85 26451632-0 2015 Reply to "Comment on "Photolysis of Polycyclic Aromatic Hydrocarbons on Water and Ice Surfaces" and on "Nonchromophoric Organic Matter Suppresses Polycyclic Aromatic Hydrocarbon Photolysis in Ice and at Ice Surfaces"". Polycyclic Aromatic Hydrocarbons 36-68 carboxylesterase 2 Homo sapiens 192-195 26451632-0 2015 Reply to "Comment on "Photolysis of Polycyclic Aromatic Hydrocarbons on Water and Ice Surfaces" and on "Nonchromophoric Organic Matter Suppresses Polycyclic Aromatic Hydrocarbon Photolysis in Ice and at Ice Surfaces"". Polycyclic Aromatic Hydrocarbons 36-68 carboxylesterase 2 Homo sapiens 192-195 26451632-0 2015 Reply to "Comment on "Photolysis of Polycyclic Aromatic Hydrocarbons on Water and Ice Surfaces" and on "Nonchromophoric Organic Matter Suppresses Polycyclic Aromatic Hydrocarbon Photolysis in Ice and at Ice Surfaces"". Water 72-77 carboxylesterase 2 Homo sapiens 192-195 26451632-0 2015 Reply to "Comment on "Photolysis of Polycyclic Aromatic Hydrocarbons on Water and Ice Surfaces" and on "Nonchromophoric Organic Matter Suppresses Polycyclic Aromatic Hydrocarbon Photolysis in Ice and at Ice Surfaces"". Water 72-77 carboxylesterase 2 Homo sapiens 192-195 26451632-0 2015 Reply to "Comment on "Photolysis of Polycyclic Aromatic Hydrocarbons on Water and Ice Surfaces" and on "Nonchromophoric Organic Matter Suppresses Polycyclic Aromatic Hydrocarbon Photolysis in Ice and at Ice Surfaces"". Polycyclic Aromatic Hydrocarbons 36-67 carboxylesterase 2 Homo sapiens 82-85 26509550-2 2015 Hydrolysis of CPT-11 by human carboxylesterase 2 (CE2) generates SN-38, a topoisomerase I inhibitor that is the active anti-tumor agent. Irinotecan 14-20 carboxylesterase 2 Homo sapiens 30-48 26451632-0 2015 Reply to "Comment on "Photolysis of Polycyclic Aromatic Hydrocarbons on Water and Ice Surfaces" and on "Nonchromophoric Organic Matter Suppresses Polycyclic Aromatic Hydrocarbon Photolysis in Ice and at Ice Surfaces"". Polycyclic Aromatic Hydrocarbons 36-67 carboxylesterase 2 Homo sapiens 192-195 26451632-0 2015 Reply to "Comment on "Photolysis of Polycyclic Aromatic Hydrocarbons on Water and Ice Surfaces" and on "Nonchromophoric Organic Matter Suppresses Polycyclic Aromatic Hydrocarbon Photolysis in Ice and at Ice Surfaces"". Polycyclic Aromatic Hydrocarbons 36-67 carboxylesterase 2 Homo sapiens 192-195 26509550-2 2015 Hydrolysis of CPT-11 by human carboxylesterase 2 (CE2) generates SN-38, a topoisomerase I inhibitor that is the active anti-tumor agent. Irinotecan 14-20 carboxylesterase 2 Homo sapiens 50-53 26509550-2 2015 Hydrolysis of CPT-11 by human carboxylesterase 2 (CE2) generates SN-38, a topoisomerase I inhibitor that is the active anti-tumor agent. Irinotecan 65-70 carboxylesterase 2 Homo sapiens 30-48 26509550-2 2015 Hydrolysis of CPT-11 by human carboxylesterase 2 (CE2) generates SN-38, a topoisomerase I inhibitor that is the active anti-tumor agent. Irinotecan 65-70 carboxylesterase 2 Homo sapiens 50-53 26509550-9 2015 Cancer cells that expressed all three forms of CE2 were more sensitive to CPT-11 as compared to unmodified cancer cells, but the membrane-anchored and ER-retained forms of CE2 were consistently more effective than secreted CE2. Irinotecan 74-80 carboxylesterase 2 Homo sapiens 47-50 26509550-10 2015 We conclude that expression of CE2 in the ER or on the membrane of cancer cells is suitable for enhancing CPT-11 anticancer activity. Irinotecan 106-112 carboxylesterase 2 Homo sapiens 31-34 26339489-1 2015 BACKGROUND: Ice swimming for 1 mile and 1 km is a new discipline in open-water swimming since 2009. Water 73-78 carboxylesterase 2 Homo sapiens 12-15 26722881-0 2015 Potential Sites for Ice Nucleation on Aluminosilicate Clay Minerals and Related Materials. aluminosilicate 38-53 carboxylesterase 2 Homo sapiens 20-23 26722881-4 2015 This Perspective focuses on what is currently known about surface sites for ice nucleation on aluminosilicate clay minerals, which are commonly found in ice residuals, as well as related materials. aluminosilicate 94-109 carboxylesterase 2 Homo sapiens 76-79 26722881-4 2015 This Perspective focuses on what is currently known about surface sites for ice nucleation on aluminosilicate clay minerals, which are commonly found in ice residuals, as well as related materials. aluminosilicate 94-109 carboxylesterase 2 Homo sapiens 153-156 26365969-0 2015 Ifosfamide, Cisplatin or Carboplatin, and Etoposide (ICE)-based Chemotherapy for Mobilization of Autologous Peripheral Blood Stem Cells in Patients with Lymphomas. Ifosfamide 0-10 carboxylesterase 2 Homo sapiens 53-56 26365969-0 2015 Ifosfamide, Cisplatin or Carboplatin, and Etoposide (ICE)-based Chemotherapy for Mobilization of Autologous Peripheral Blood Stem Cells in Patients with Lymphomas. Etoposide 42-51 carboxylesterase 2 Homo sapiens 53-56 26365969-2 2015 This study aimed to evaluate the effect of ifosfamide, cisplatin or carboplatin, and etoposide (ICE)-based regimen as a mobilization regimen on relapsed, refractory, or high-risk aggressive lymphoma. Etoposide 85-94 carboxylesterase 2 Homo sapiens 96-99 26425784-0 2015 Protostane Triterpenoids from the Rhizome of Alisma orientale Exhibit Inhibitory Effects on Human Carboxylesterase 2. protostane 0-10 carboxylesterase 2 Homo sapiens 98-116 26425784-0 2015 Protostane Triterpenoids from the Rhizome of Alisma orientale Exhibit Inhibitory Effects on Human Carboxylesterase 2. triterpenoids 11-24 carboxylesterase 2 Homo sapiens 98-116 26164127-3 2015 It is generally recognized that CES1 prefers compounds with a large acyl moiety and a small alcohol or amine moiety as substrates, whereas CES2 prefers compounds with a small acyl moiety and a large alcohol or amine moiety. Alcohols 199-206 carboxylesterase 2 Homo sapiens 139-143 26164127-3 2015 It is generally recognized that CES1 prefers compounds with a large acyl moiety and a small alcohol or amine moiety as substrates, whereas CES2 prefers compounds with a small acyl moiety and a large alcohol or amine moiety. Amines 210-215 carboxylesterase 2 Homo sapiens 139-143 26164127-7 2015 Recombinant AADAC catalyzed the hydrolysis of fluorescein diacetate, N-monoacetyldapsone, and propanil, which possess notably small acyl moieties, and these substrates were also hydrolyzed by CES2. diacetylfluorescein 46-67 carboxylesterase 2 Homo sapiens 192-196 26164127-7 2015 Recombinant AADAC catalyzed the hydrolysis of fluorescein diacetate, N-monoacetyldapsone, and propanil, which possess notably small acyl moieties, and these substrates were also hydrolyzed by CES2. n-monoacetyldapsone 69-88 carboxylesterase 2 Homo sapiens 192-196 26164127-7 2015 Recombinant AADAC catalyzed the hydrolysis of fluorescein diacetate, N-monoacetyldapsone, and propanil, which possess notably small acyl moieties, and these substrates were also hydrolyzed by CES2. Propanil 94-102 carboxylesterase 2 Homo sapiens 192-196 26360463-4 2015 We discovered that pyruvyl anilide is specifically hydrolyzed by carboxylesterase 2 (CES2), which is predominantly localized in the liver and kidney. pyruvyl anilide 19-34 carboxylesterase 2 Homo sapiens 65-83 26360463-4 2015 We discovered that pyruvyl anilide is specifically hydrolyzed by carboxylesterase 2 (CES2), which is predominantly localized in the liver and kidney. pyruvyl anilide 19-34 carboxylesterase 2 Homo sapiens 85-89 26360463-5 2015 We show that the pyruvyl targeting group/CES2 enzyme pair can be used to deliver the 7-amino-4-methylcoumarin fluorophore specifically to the liver and kidney in vivo. 7-amino-4-methylcoumarin 85-109 carboxylesterase 2 Homo sapiens 41-45 26236034-4 2015 In contrast to the formation of 1-3, the use of N-methyldiethanolamine (L) in the reaction with Ce(NO3 )3 6 H2 O and pivalic acid afforded a previously reported Ce(III) dinuclear cluster, Ce2 (O2 CtBu)6 L2 , even in the presence of dioxygen. N-methyldiethanolamine 48-70 carboxylesterase 2 Homo sapiens 189-192 26236034-4 2015 In contrast to the formation of 1-3, the use of N-methyldiethanolamine (L) in the reaction with Ce(NO3 )3 6 H2 O and pivalic acid afforded a previously reported Ce(III) dinuclear cluster, Ce2 (O2 CtBu)6 L2 , even in the presence of dioxygen. ce(no3 )3 6 h2 o 96-113 carboxylesterase 2 Homo sapiens 189-192 26236034-4 2015 In contrast to the formation of 1-3, the use of N-methyldiethanolamine (L) in the reaction with Ce(NO3 )3 6 H2 O and pivalic acid afforded a previously reported Ce(III) dinuclear cluster, Ce2 (O2 CtBu)6 L2 , even in the presence of dioxygen. pivalic acid 118-130 carboxylesterase 2 Homo sapiens 189-192 26236034-4 2015 In contrast to the formation of 1-3, the use of N-methyldiethanolamine (L) in the reaction with Ce(NO3 )3 6 H2 O and pivalic acid afforded a previously reported Ce(III) dinuclear cluster, Ce2 (O2 CtBu)6 L2 , even in the presence of dioxygen. Oxygen 233-241 carboxylesterase 2 Homo sapiens 189-192 26149412-6 2015 We further demonstrated that streptavidin and a biotinylated target protein (cocaine esterase, CocE) can be captured at predesignated sites on these flattened origami while maintaining their functional integrity. origami 159-166 carboxylesterase 2 Homo sapiens 77-93 25511794-3 2015 The aim of this study was to determine the impact of alcohol on the metabolism of specific probes for CES1 (oseltamivir) and CES2 (aspirin). Alcohols 53-60 carboxylesterase 2 Homo sapiens 125-129 25955974-0 2015 Green and blue emitting 3D structured Tb:Ce2(WO4)3 and Tb:Ce10W22O81 micromaterials. Terbium 38-40 carboxylesterase 2 Homo sapiens 41-44 25955974-1 2015 In this paper, various microstructures of Ce2(WO4)3 and Ce10W22O81 were prepared by applying a hydrothermal synthesis, in a ligand-free environment, and in the presence of a dioctyl sodium sulfosuccinate (DSS) surfactant, after which the materials were heat treated at a temperature of 900 C. Depending on the ratio of cerium ions to sodium tungstate, as well as the reaction pH, two different cerium tungstate materials were obtained. ce10w22o81 56-66 carboxylesterase 2 Homo sapiens 42-45 25955974-1 2015 In this paper, various microstructures of Ce2(WO4)3 and Ce10W22O81 were prepared by applying a hydrothermal synthesis, in a ligand-free environment, and in the presence of a dioctyl sodium sulfosuccinate (DSS) surfactant, after which the materials were heat treated at a temperature of 900 C. Depending on the ratio of cerium ions to sodium tungstate, as well as the reaction pH, two different cerium tungstate materials were obtained. laxagetten 4,4'-diacetoxydiphenylpyridylemethane 174-203 carboxylesterase 2 Homo sapiens 42-45 25955974-1 2015 In this paper, various microstructures of Ce2(WO4)3 and Ce10W22O81 were prepared by applying a hydrothermal synthesis, in a ligand-free environment, and in the presence of a dioctyl sodium sulfosuccinate (DSS) surfactant, after which the materials were heat treated at a temperature of 900 C. Depending on the ratio of cerium ions to sodium tungstate, as well as the reaction pH, two different cerium tungstate materials were obtained. laxagetten 4,4'-diacetoxydiphenylpyridylemethane 205-208 carboxylesterase 2 Homo sapiens 42-45 25955974-1 2015 In this paper, various microstructures of Ce2(WO4)3 and Ce10W22O81 were prepared by applying a hydrothermal synthesis, in a ligand-free environment, and in the presence of a dioctyl sodium sulfosuccinate (DSS) surfactant, after which the materials were heat treated at a temperature of 900 C. Depending on the ratio of cerium ions to sodium tungstate, as well as the reaction pH, two different cerium tungstate materials were obtained. Cerium 320-326 carboxylesterase 2 Homo sapiens 42-45 25955974-1 2015 In this paper, various microstructures of Ce2(WO4)3 and Ce10W22O81 were prepared by applying a hydrothermal synthesis, in a ligand-free environment, and in the presence of a dioctyl sodium sulfosuccinate (DSS) surfactant, after which the materials were heat treated at a temperature of 900 C. Depending on the ratio of cerium ions to sodium tungstate, as well as the reaction pH, two different cerium tungstate materials were obtained. sodium tungstate(VI) 335-351 carboxylesterase 2 Homo sapiens 42-45 25955974-1 2015 In this paper, various microstructures of Ce2(WO4)3 and Ce10W22O81 were prepared by applying a hydrothermal synthesis, in a ligand-free environment, and in the presence of a dioctyl sodium sulfosuccinate (DSS) surfactant, after which the materials were heat treated at a temperature of 900 C. Depending on the ratio of cerium ions to sodium tungstate, as well as the reaction pH, two different cerium tungstate materials were obtained. Cerium tungstate 395-411 carboxylesterase 2 Homo sapiens 42-45 26137444-6 2015 The epileptic component (ICE) was identified by selecting the RSN component with the largest overlap with the EEG-fMRI correlation pattern. (3~{S})-3-azanyl-4-[[(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxysulfonylamino]-4-oxidanylidene-butanoic acid 62-65 carboxylesterase 2 Homo sapiens 25-28 26001916-5 2015 Different forms of methamphetamine - ICE, powder, and pills - have different pharmacokinetic characteristics that make them popular among certain types of users. Methamphetamine 19-34 carboxylesterase 2 Homo sapiens 37-40 26073578-7 2015 Hydrolysis of BJ-B11 was markedly inhibited by vinblastine (a dual inhibitor of arylacetamide deacetylase and carboxylesterase 2). Vinblastine 47-58 carboxylesterase 2 Homo sapiens 110-128 26073578-8 2015 By contrast, digitonin and telmisartan (the specific inhibitors for carboxylesterase 1 and carboxylesterase 2, respectively) did not inhibit BJ-B11 hydrolysis at all. Telmisartan 27-38 carboxylesterase 2 Homo sapiens 91-109 25511794-3 2015 The aim of this study was to determine the impact of alcohol on the metabolism of specific probes for CES1 (oseltamivir) and CES2 (aspirin). Aspirin 131-138 carboxylesterase 2 Homo sapiens 125-129 25511794-4 2015 METHODS: The effect of alcohol on CES1- and CES2-mediated probe drug hydrolysis was determined in vitro using recombinant human carboxylesterase. Alcohols 23-30 carboxylesterase 2 Homo sapiens 44-48 26221234-6 2015 He was subsequently treated with five courses of the salvage chemotherapy regimen ICE (ifosfamide, carboplatin and etoposide) and achieved PR again. Ifosfamide 87-97 carboxylesterase 2 Homo sapiens 82-85 26025324-0 2015 Carboxylesterase 2 as a Determinant of Response to Irinotecan and Neoadjuvant FOLFIRINOX Therapy in Pancreatic Ductal Adenocarcinoma. Irinotecan 51-61 carboxylesterase 2 Homo sapiens 0-18 26025324-0 2015 Carboxylesterase 2 as a Determinant of Response to Irinotecan and Neoadjuvant FOLFIRINOX Therapy in Pancreatic Ductal Adenocarcinoma. folfirinox 78-88 carboxylesterase 2 Homo sapiens 0-18 26025324-2 2015 We have undertaken a comprehensive proteomic analysis to assess the differential expression and cellular localization of SHs, which uncovered distinctive expression of Carboxylesterase 2 (CES2), the most efficient carboxyl esterase in activating the prodrug irinotecan into SN-38, in pancreatic ductal adenocarcinoma (PDAC). Irinotecan 258-268 carboxylesterase 2 Homo sapiens 168-186 26025324-2 2015 We have undertaken a comprehensive proteomic analysis to assess the differential expression and cellular localization of SHs, which uncovered distinctive expression of Carboxylesterase 2 (CES2), the most efficient carboxyl esterase in activating the prodrug irinotecan into SN-38, in pancreatic ductal adenocarcinoma (PDAC). Irinotecan 258-268 carboxylesterase 2 Homo sapiens 188-192 26025324-2 2015 We have undertaken a comprehensive proteomic analysis to assess the differential expression and cellular localization of SHs, which uncovered distinctive expression of Carboxylesterase 2 (CES2), the most efficient carboxyl esterase in activating the prodrug irinotecan into SN-38, in pancreatic ductal adenocarcinoma (PDAC). Irinotecan 274-279 carboxylesterase 2 Homo sapiens 168-186 26025324-2 2015 We have undertaken a comprehensive proteomic analysis to assess the differential expression and cellular localization of SHs, which uncovered distinctive expression of Carboxylesterase 2 (CES2), the most efficient carboxyl esterase in activating the prodrug irinotecan into SN-38, in pancreatic ductal adenocarcinoma (PDAC). Irinotecan 274-279 carboxylesterase 2 Homo sapiens 188-192 26025324-5 2015 CES2 activity was assessed by monitoring the hydrolysis of the substrate p-NPA and correlated with irinotecan IC50 values by means of Pearson"s correlation. Irinotecan 99-109 carboxylesterase 2 Homo sapiens 0-4 26025324-6 2015 Kaplan-Meier and Cox regression analyses were applied to assess the association between overall survival and CES2 expression in patients who underwent neoadjuvant FOLFIRINOX treatment. folfirinox 163-173 carboxylesterase 2 Homo sapiens 109-113 26025324-9 2015 CES2 activity in 11 PDAC cell lines was inversely correlated with irinotecan IC50 values (R = -0.68, P = .02). Irinotecan 66-76 carboxylesterase 2 Homo sapiens 0-4 26025324-10 2015 High CES2 expression in tumor tissue was associated with longer overall survival in resectable and borderline resectable patients who underwent neoadjuvant FOLFIRINOX treatment (hazard ratio = 0.14, 95% confidence interval = 0.04 to 0.51, P = .02). folfirinox 156-166 carboxylesterase 2 Homo sapiens 5-9 26025324-11 2015 CONCLUSION: Our findings suggest that CES2 expression and activity, by mediating the intratumoral activation of irinotecan, is a contributor to FOLFIRINOX sensitivity in pancreatic cancer and CES2 assessment may define a subset of patients likely to respond to irinotecan based therapy. Irinotecan 112-122 carboxylesterase 2 Homo sapiens 38-42 26025324-11 2015 CONCLUSION: Our findings suggest that CES2 expression and activity, by mediating the intratumoral activation of irinotecan, is a contributor to FOLFIRINOX sensitivity in pancreatic cancer and CES2 assessment may define a subset of patients likely to respond to irinotecan based therapy. folfirinox 144-154 carboxylesterase 2 Homo sapiens 38-42 26025324-11 2015 CONCLUSION: Our findings suggest that CES2 expression and activity, by mediating the intratumoral activation of irinotecan, is a contributor to FOLFIRINOX sensitivity in pancreatic cancer and CES2 assessment may define a subset of patients likely to respond to irinotecan based therapy. Irinotecan 261-271 carboxylesterase 2 Homo sapiens 38-42 26221234-6 2015 He was subsequently treated with five courses of the salvage chemotherapy regimen ICE (ifosfamide, carboplatin and etoposide) and achieved PR again. Carboplatin 99-110 carboxylesterase 2 Homo sapiens 82-85 26221234-6 2015 He was subsequently treated with five courses of the salvage chemotherapy regimen ICE (ifosfamide, carboplatin and etoposide) and achieved PR again. Etoposide 115-124 carboxylesterase 2 Homo sapiens 82-85 25461132-1 2015 A new ratiometric florescence probe derived from 3-hydroxyflavone (3-HF) has been developed for selective and sensitive detection of human carboxylesterase 2 (CE2). 3-hydroxyflavone 49-65 carboxylesterase 2 Homo sapiens 139-157 25461132-1 2015 A new ratiometric florescence probe derived from 3-hydroxyflavone (3-HF) has been developed for selective and sensitive detection of human carboxylesterase 2 (CE2). 3-hydroxyflavone 49-65 carboxylesterase 2 Homo sapiens 159-162 25311755-2 2015 The aim of the following study was to test the effects of pre-cooling on female repeat sprint performance in hot, humid conditions; namely is ice ingestion effective in reducing core temperature (Tc) and does this reduced Tc lead to improved repeat sprint performance in female athletes? Technetium 196-198 carboxylesterase 2 Homo sapiens 142-145 25596095-2 2015 This study aimed to investigate the inhibitory effects of the crude ethanol extract from FP on human carboxylesterase 2 (hCE2), as well as to identity and characterize the naturally occurring inhibitors of hCE2 in FP. Ethanol 68-75 carboxylesterase 2 Homo sapiens 101-119 25596095-2 2015 This study aimed to investigate the inhibitory effects of the crude ethanol extract from FP on human carboxylesterase 2 (hCE2), as well as to identity and characterize the naturally occurring inhibitors of hCE2 in FP. Ethanol 68-75 carboxylesterase 2 Homo sapiens 121-125 25596095-3 2015 Our results demonstrated that the ethanol extract of FP displayed potent inhibitory effects towards hCE2, while five major bioactive constitutes in FP were efficiently identified by LC-DAD-ESI-MS/MS, with the aid of LC-based activity profiling. Ethanol 34-41 carboxylesterase 2 Homo sapiens 100-104 25596095-4 2015 The identified bioactive compounds including neobavaisoflavone, isobavachalcone, bavachinin, corylifol A and bakuchiol were found to be naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62muM to 3.89muM. neobavaisoflavone 45-62 carboxylesterase 2 Homo sapiens 177-181 25596095-4 2015 The identified bioactive compounds including neobavaisoflavone, isobavachalcone, bavachinin, corylifol A and bakuchiol were found to be naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62muM to 3.89muM. isobavachalcone 64-79 carboxylesterase 2 Homo sapiens 177-181 25596095-4 2015 The identified bioactive compounds including neobavaisoflavone, isobavachalcone, bavachinin, corylifol A and bakuchiol were found to be naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62muM to 3.89muM. bavachinin 81-91 carboxylesterase 2 Homo sapiens 177-181 25596095-4 2015 The identified bioactive compounds including neobavaisoflavone, isobavachalcone, bavachinin, corylifol A and bakuchiol were found to be naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62muM to 3.89muM. corylifol A 93-104 carboxylesterase 2 Homo sapiens 177-181 25596095-4 2015 The identified bioactive compounds including neobavaisoflavone, isobavachalcone, bavachinin, corylifol A and bakuchiol were found to be naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62muM to 3.89muM. bakuchiol 109-118 carboxylesterase 2 Homo sapiens 177-181 25640165-6 2015 We show for an electron-electron-nuclear model system that the change in nuclear polarization can be caused by direct MW irradiation on the CE electron transitions, resulting in a direct CE (dCE) enhancement, or by the influence of the eSD process on the spin system, resulting in nuclear enhancements via a process we term the indirect CE (iCE). ethylene dichloride 191-194 carboxylesterase 2 Homo sapiens 341-344 25445008-7 2015 Compounds bearing a small alcohol part and a larger acyl part showed higher affinity to hCES1 while those with a large alcohol part showed higher affinity to hCES2. Alcohols 119-126 carboxylesterase 2 Homo sapiens 158-163 25311755-6 2015 At the end of the pre-cooling period, Tc significantly decreased following ICE (-0.7 +- 0.3 C) compared to CON (-0.1 +- 0.2 C; p = 0.001). Technetium 38-40 carboxylesterase 2 Homo sapiens 75-78 25311755-7 2015 Tc also remained lower in ICE compared to CON during the ISP (p = 0.001). Technetium 0-2 carboxylesterase 2 Homo sapiens 26-29 25311755-10 2015 Ice ingestion significantly reduced female Tc prior to intermittent exercise in the heat and reduced thermal sensation; however, this did not coincide with improved performance. Technetium 43-45 carboxylesterase 2 Homo sapiens 0-3 24944079-1 2014 ICE/R-ICE (ifosfamide, carboplatin, and etoposide without or with rituximab) chemotherapy followed by autologous stem cell transplantation is an established regimen in refractory/relapsed lymphoma. Ifosfamide 11-21 carboxylesterase 2 Homo sapiens 0-3 25801056-10 2015 The knockdown of HIF-1alpha or DEC1 with shRNA construct abrogated the decrease of the CES1 and CES2 expression induced by the insulin in high glucose condition in HepG2 cells. Glucose 143-150 carboxylesterase 2 Homo sapiens 96-100 25303144-1 2014 A highly selective long-wavelength fluorescent probe TCFB has been developed for the detection of hCE2. tcfb 53-57 carboxylesterase 2 Homo sapiens 98-102 25303639-5 2014 Two distinct pathways by which the target compounds undergo effective ester hydrolysis, the proposed activating step, have been confirmed: platinum-assisted, self-immolative ester cleavage in a low-chloride environment (LC-ESMS, NMR spectroscopy) and enzymatic cleavage by human carboxylesterase-2 (hCES-2) (LC-ESMS). Esters 70-75 carboxylesterase 2 Homo sapiens 279-297 25303639-5 2014 Two distinct pathways by which the target compounds undergo effective ester hydrolysis, the proposed activating step, have been confirmed: platinum-assisted, self-immolative ester cleavage in a low-chloride environment (LC-ESMS, NMR spectroscopy) and enzymatic cleavage by human carboxylesterase-2 (hCES-2) (LC-ESMS). Esters 70-75 carboxylesterase 2 Homo sapiens 299-305 25303639-5 2014 Two distinct pathways by which the target compounds undergo effective ester hydrolysis, the proposed activating step, have been confirmed: platinum-assisted, self-immolative ester cleavage in a low-chloride environment (LC-ESMS, NMR spectroscopy) and enzymatic cleavage by human carboxylesterase-2 (hCES-2) (LC-ESMS). Platinum 139-147 carboxylesterase 2 Homo sapiens 279-297 25303639-5 2014 Two distinct pathways by which the target compounds undergo effective ester hydrolysis, the proposed activating step, have been confirmed: platinum-assisted, self-immolative ester cleavage in a low-chloride environment (LC-ESMS, NMR spectroscopy) and enzymatic cleavage by human carboxylesterase-2 (hCES-2) (LC-ESMS). Platinum 139-147 carboxylesterase 2 Homo sapiens 299-305 25530926-0 2014 Excipients of preservative-free latanoprost induced inflammatory response and cytotoxicity in immortalized human HCE-2 corneal epithelial cells. Latanoprost 32-43 carboxylesterase 2 Homo sapiens 113-118 24944079-1 2014 ICE/R-ICE (ifosfamide, carboplatin, and etoposide without or with rituximab) chemotherapy followed by autologous stem cell transplantation is an established regimen in refractory/relapsed lymphoma. Ifosfamide 11-21 carboxylesterase 2 Homo sapiens 6-9 24944079-1 2014 ICE/R-ICE (ifosfamide, carboplatin, and etoposide without or with rituximab) chemotherapy followed by autologous stem cell transplantation is an established regimen in refractory/relapsed lymphoma. Carboplatin 23-34 carboxylesterase 2 Homo sapiens 0-3 24944079-1 2014 ICE/R-ICE (ifosfamide, carboplatin, and etoposide without or with rituximab) chemotherapy followed by autologous stem cell transplantation is an established regimen in refractory/relapsed lymphoma. Carboplatin 23-34 carboxylesterase 2 Homo sapiens 6-9 24944079-1 2014 ICE/R-ICE (ifosfamide, carboplatin, and etoposide without or with rituximab) chemotherapy followed by autologous stem cell transplantation is an established regimen in refractory/relapsed lymphoma. Etoposide 40-49 carboxylesterase 2 Homo sapiens 0-3 24944079-1 2014 ICE/R-ICE (ifosfamide, carboplatin, and etoposide without or with rituximab) chemotherapy followed by autologous stem cell transplantation is an established regimen in refractory/relapsed lymphoma. Etoposide 40-49 carboxylesterase 2 Homo sapiens 6-9 24984185-1 2014 Ice lenses are formed during soil freezing by the migration and solidification of premelted water that is adsorbed to ice-particle interfaces and confined to capillary regions. Water 92-97 carboxylesterase 2 Homo sapiens 0-3 24984185-1 2014 Ice lenses are formed during soil freezing by the migration and solidification of premelted water that is adsorbed to ice-particle interfaces and confined to capillary regions. Water 92-97 carboxylesterase 2 Homo sapiens 118-121 25148646-2 2014 Protonolysis reactions of Ce[N(SiHMe2)2]4 with tert-butanol, substituted benzyl alcohols, and 2,6-diphenylphenol yielded the neutral tetravalent compounds Ce(O(t)Bu)4(py)2, Ce2(OCH2C6R5)8(thf)2 (R = Me, F), and Ce(Odpp)4 (dpp = 2,6-(C6H5)2-C6H3). ce[n(sihme2)2]4 26-41 carboxylesterase 2 Homo sapiens 173-176 25148646-2 2014 Protonolysis reactions of Ce[N(SiHMe2)2]4 with tert-butanol, substituted benzyl alcohols, and 2,6-diphenylphenol yielded the neutral tetravalent compounds Ce(O(t)Bu)4(py)2, Ce2(OCH2C6R5)8(thf)2 (R = Me, F), and Ce(Odpp)4 (dpp = 2,6-(C6H5)2-C6H3). 2,6-Diphenylphenol 94-112 carboxylesterase 2 Homo sapiens 173-176 24946981-5 2014 Complex phases composed of anatase, rutile and amorphous TiO2 were identified in ALF, ICE and LLK. titanium dioxide 57-61 carboxylesterase 2 Homo sapiens 86-97 25260839-6 2014 CONCLUSIONS: The cytotoxicity of CPT-11 to colorectal cancer cells has a negative correlation with UGT1A1 expression, and positive correlation with CES2 and GUSB. Irinotecan 33-39 carboxylesterase 2 Homo sapiens 148-152 25399194-0 2014 Homogeneous ice nucleation evaluated for several water models. Water 49-54 carboxylesterase 2 Homo sapiens 12-15 25399194-1 2014 In this work, we evaluate by means of computer simulations the rate for ice homogeneous nucleation for several water models such as TIP4P, TIP4P/2005,TIP4P/ICE, and mW (following the same procedure as in Sanz et al. Water 111-116 carboxylesterase 2 Homo sapiens 72-75 25399194-7 2014 We estimate the ice-liquid interfacial free-energy, and conclude that for all water models gamma decreases as the temperature decreases. Water 78-83 carboxylesterase 2 Homo sapiens 16-19 24727322-9 2014 Everolimus also markedly inhibited the hydrolysis of irinotecan and p-nitrophenyl acetate by mouse plasma carboxylesterase and recombinant human CES2, respectively. Everolimus 0-10 carboxylesterase 2 Homo sapiens 145-149 33412696-3 2014 To date, many applications related to the design and development of functional ice cream have been documented, including products containing probiotics, prebiotics, synbiotics, dietary fibers, natural antioxidants such as polyphenols, essential and polyunsaturated fatty acids, and low glycemic index blends and blends fortified with mineral or trace elements. Polyphenols 222-233 carboxylesterase 2 Homo sapiens 79-82 33412696-3 2014 To date, many applications related to the design and development of functional ice cream have been documented, including products containing probiotics, prebiotics, synbiotics, dietary fibers, natural antioxidants such as polyphenols, essential and polyunsaturated fatty acids, and low glycemic index blends and blends fortified with mineral or trace elements. Fatty Acids, Unsaturated 249-276 carboxylesterase 2 Homo sapiens 79-82 24751575-6 2014 We screened 542 chemicals for the inhibition potency toward hydrolase activities of p-nitrophenyl acetate by recombinant CES1, CES2, and AADAC. 4-nitrophenyl acetate 84-105 carboxylesterase 2 Homo sapiens 127-131 24751575-7 2014 We found that digitonin and telmisartan specifically inhibited CES1 and CES2 enzyme activity, respectively. Digitonin 14-23 carboxylesterase 2 Homo sapiens 72-76 24751575-7 2014 We found that digitonin and telmisartan specifically inhibited CES1 and CES2 enzyme activity, respectively. Telmisartan 28-39 carboxylesterase 2 Homo sapiens 72-76 24751575-8 2014 Vinblastine potently inhibited both AADAC and CES2, but no specific inhibitor of AADAC was found. Vinblastine 0-11 carboxylesterase 2 Homo sapiens 46-50 24727322-9 2014 Everolimus also markedly inhibited the hydrolysis of irinotecan and p-nitrophenyl acetate by mouse plasma carboxylesterase and recombinant human CES2, respectively. Irinotecan 53-63 carboxylesterase 2 Homo sapiens 145-149 24727322-9 2014 Everolimus also markedly inhibited the hydrolysis of irinotecan and p-nitrophenyl acetate by mouse plasma carboxylesterase and recombinant human CES2, respectively. 4-nitrophenyl acetate 68-89 carboxylesterase 2 Homo sapiens 145-149 24409457-1 2014 Multichromophoric dye-sensitized solar cells (DSSCs) comprised of a supramolecular zinc-phthalocyanineperyleneimide (ZnPc PMI) dyad convert light to electrical energy with much higher power conversion efficiency (PCE = 2.3%) and incident-photon-to-current-efficiency (IPCE = ca. zinc-phthalocyanineperyleneimide 83-115 carboxylesterase 2 Homo sapiens 215-222 24409457-1 2014 Multichromophoric dye-sensitized solar cells (DSSCs) comprised of a supramolecular zinc-phthalocyanineperyleneimide (ZnPc PMI) dyad convert light to electrical energy with much higher power conversion efficiency (PCE = 2.3%) and incident-photon-to-current-efficiency (IPCE = ca. zinc(II) phthalocyanine trisulfonic acid 117-121 carboxylesterase 2 Homo sapiens 215-222 24607128-3 2014 This made it possible to determine trace copper in HeLa cell only by a simple cell extraction (CE2) treatment. Copper 41-47 carboxylesterase 2 Homo sapiens 95-98 24699684-1 2014 Two major forms of human carboxylesterase (CES), CES1A and CES2, dominate the pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11). imidapril 120-129 carboxylesterase 2 Homo sapiens 59-63 24699684-1 2014 Two major forms of human carboxylesterase (CES), CES1A and CES2, dominate the pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11). Irinotecan 134-144 carboxylesterase 2 Homo sapiens 59-63 24699684-1 2014 Two major forms of human carboxylesterase (CES), CES1A and CES2, dominate the pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11). Irinotecan 146-152 carboxylesterase 2 Homo sapiens 59-63 24699684-7 2014 The enzyme hydrolase activity of recombinant CES2 was substantially inhibited by Tween 20 and polyoxyl 35 castor oil (EL35) (K(i) = 0.93 +- 0.36 mug/ml and 4.4 +- 1.24 mug/ml, respectively). Polysorbates 81-89 carboxylesterase 2 Homo sapiens 45-49 24699684-7 2014 The enzyme hydrolase activity of recombinant CES2 was substantially inhibited by Tween 20 and polyoxyl 35 castor oil (EL35) (K(i) = 0.93 +- 0.36 mug/ml and 4.4 +- 1.24 mug/ml, respectively). cremophor EL 94-116 carboxylesterase 2 Homo sapiens 45-49 24464802-6 2014 The indiplon hydrolase activity of HLM was potently inhibited by vinblastine, a potent inhibitor of AADAC and CES2, but it was not inhibited by digitonin and telmisartan, inhibitors of CES1 and CES2, respectively. Vinblastine 65-76 carboxylesterase 2 Homo sapiens 110-114 24464802-6 2014 The indiplon hydrolase activity of HLM was potently inhibited by vinblastine, a potent inhibitor of AADAC and CES2, but it was not inhibited by digitonin and telmisartan, inhibitors of CES1 and CES2, respectively. Vinblastine 65-76 carboxylesterase 2 Homo sapiens 194-198 24461291-2 2014 The anticipated pathway of carboxylesterase-1-mediated carbamate cleavage followed by lactamization and drug release was frustrated by unexpectedly high sensitivity of the ester linkage toward hydrolysis by carboxylesterase-2 and other microsomal components. Carbamates 55-64 carboxylesterase 2 Homo sapiens 207-225 24462278-16 2014 Diluted Cationorm and Systane with polyquaternium-1/polidronium chloride 0.001% showed good tolerability on HCE-2 cells and thereby provide a clear improvement when compared to BAK-containing eye drop formulations. polyquaternium 1 35-51 carboxylesterase 2 Homo sapiens 108-113 24462278-16 2014 Diluted Cationorm and Systane with polyquaternium-1/polidronium chloride 0.001% showed good tolerability on HCE-2 cells and thereby provide a clear improvement when compared to BAK-containing eye drop formulations. polyquaternium 1 52-72 carboxylesterase 2 Homo sapiens 108-113 24461291-2 2014 The anticipated pathway of carboxylesterase-1-mediated carbamate cleavage followed by lactamization and drug release was frustrated by unexpectedly high sensitivity of the ester linkage toward hydrolysis by carboxylesterase-2 and other microsomal components. Esters 35-40 carboxylesterase 2 Homo sapiens 207-225 24439671-0 2014 Regulation and expression of aberrant methylation on irinotecan metabolic genes CES2, UGT1A1 and GUSB in the in-vitro cultured colorectal cancer cells. Irinotecan 53-63 carboxylesterase 2 Homo sapiens 80-84 24140606-7 2014 Moreover, UDMA stimulated COX-2, HO-1 and CES2 mRNA expression of pulp cells. urethane dimethacrylate luting resin 10-14 carboxylesterase 2 Homo sapiens 42-46 24140606-8 2014 The cytotoxicity of UDMA was attenuated by N-acetyl-l-cysteine, catalase and esterase, but was enhanced by Zn-protoporphyrin (HO-1 inhibitor), BNPP (CES inhibitor) and loperamide (CES2 inhibitor). urethane dimethacrylate luting resin 20-24 carboxylesterase 2 Homo sapiens 180-184 24212379-3 2014 The kinetics of DABE hydrolysis in two human recombinant carboxylesterase enzymes (CES1 and CES2) and in human intestinal microsomes and human liver S9 fractions were determined. Dabigatran 16-20 carboxylesterase 2 Homo sapiens 92-96 24212379-6 2014 The ethyl ester of DABE was hydrolyzed exclusively by CES1 to M1 (Km 24.9 +- 2.9 muM, Vmax 676 +- 26 pmol/min per milligram protein) and the carbamate ester of DABE was exclusively hydrolyzed by CES2 to M2 (Km 5.5 +- 0.8 muM; Vmax 71.1 +- 2.4 pmol/min per milligram protein). ethyl ester 4-15 carboxylesterase 2 Homo sapiens 195-199 24212377-4 2014 Experiments using expressed carboxylesterase 1 (CES1) and CES2 bactosomes revealed that dabigatran etexilate was hydrolyzed into BIBR 1087 by CES1 expressed in our Caco-2 cells. Dabigatran 88-108 carboxylesterase 2 Homo sapiens 58-62 24212379-6 2014 The ethyl ester of DABE was hydrolyzed exclusively by CES1 to M1 (Km 24.9 +- 2.9 muM, Vmax 676 +- 26 pmol/min per milligram protein) and the carbamate ester of DABE was exclusively hydrolyzed by CES2 to M2 (Km 5.5 +- 0.8 muM; Vmax 71.1 +- 2.4 pmol/min per milligram protein). Dabigatran 19-23 carboxylesterase 2 Homo sapiens 195-199 24212379-6 2014 The ethyl ester of DABE was hydrolyzed exclusively by CES1 to M1 (Km 24.9 +- 2.9 muM, Vmax 676 +- 26 pmol/min per milligram protein) and the carbamate ester of DABE was exclusively hydrolyzed by CES2 to M2 (Km 5.5 +- 0.8 muM; Vmax 71.1 +- 2.4 pmol/min per milligram protein). carbamate ester 141-156 carboxylesterase 2 Homo sapiens 195-199 24212377-4 2014 Experiments using expressed carboxylesterase 1 (CES1) and CES2 bactosomes revealed that dabigatran etexilate was hydrolyzed into BIBR 1087 by CES1 expressed in our Caco-2 cells. bibr 129-133 carboxylesterase 2 Homo sapiens 58-62 24212379-8 2014 These results suggest that after oral administration of DABE to humans, DABE is hydrolyzed by intestinal CES2 to the intermediate M2 metabolite followed by hydrolysis of M2 to DAB in the liver by CES1. Dabigatran 56-60 carboxylesterase 2 Homo sapiens 105-109 24212379-8 2014 These results suggest that after oral administration of DABE to humans, DABE is hydrolyzed by intestinal CES2 to the intermediate M2 metabolite followed by hydrolysis of M2 to DAB in the liver by CES1. Dabigatran 72-76 carboxylesterase 2 Homo sapiens 105-109 24212379-8 2014 These results suggest that after oral administration of DABE to humans, DABE is hydrolyzed by intestinal CES2 to the intermediate M2 metabolite followed by hydrolysis of M2 to DAB in the liver by CES1. Dabigatran 56-59 carboxylesterase 2 Homo sapiens 105-109 24355169-9 2014 Carboxylesterase isoforms, CES1b and CES1c, and CES2, exhibited significant transesterification activity toward parabens, and showed similar substrate specificity to human liver and small-intestinal microsomes, respectively. Parabens 112-120 carboxylesterase 2 Homo sapiens 0-16 24355169-9 2014 Carboxylesterase isoforms, CES1b and CES1c, and CES2, exhibited significant transesterification activity toward parabens, and showed similar substrate specificity to human liver and small-intestinal microsomes, respectively. Parabens 112-120 carboxylesterase 2 Homo sapiens 48-52 24988246-1 2014 Human carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are serine esterases responsible for the hydrolysis of ester and amide bonds present in a number of pharmaceutical products. Esters 14-19 carboxylesterase 2 Homo sapiens 36-54 24141856-4 2014 Here, we studied recombinant human CES1- and CES2-mediated hydrolytic activation of the prodrug esters enalapril and ramipril, compared with the activation of the known substrate trandolapril. Esters 96-102 carboxylesterase 2 Homo sapiens 45-49 24141856-4 2014 Here, we studied recombinant human CES1- and CES2-mediated hydrolytic activation of the prodrug esters enalapril and ramipril, compared with the activation of the known substrate trandolapril. Enalapril 103-112 carboxylesterase 2 Homo sapiens 45-49 24141856-4 2014 Here, we studied recombinant human CES1- and CES2-mediated hydrolytic activation of the prodrug esters enalapril and ramipril, compared with the activation of the known substrate trandolapril. Ramipril 117-125 carboxylesterase 2 Homo sapiens 45-49 24179032-2 2014 The hydrolysis of CDP323 was evaluated in vitro using human liver and intestinal microsomes and recombinant human carboxylesterases (hCES1 and 2) and was shown to be approximately 20-fold higher in human liver microsomes when compared with human intestinal microsomes and in hCES1 when compared with hCES2. CDP323 18-24 carboxylesterase 2 Homo sapiens 300-305 24988246-1 2014 Human carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are serine esterases responsible for the hydrolysis of ester and amide bonds present in a number of pharmaceutical products. Esters 14-19 carboxylesterase 2 Homo sapiens 56-60 24988246-1 2014 Human carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are serine esterases responsible for the hydrolysis of ester and amide bonds present in a number of pharmaceutical products. Amides 127-132 carboxylesterase 2 Homo sapiens 36-54 24988246-1 2014 Human carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are serine esterases responsible for the hydrolysis of ester and amide bonds present in a number of pharmaceutical products. Amides 127-132 carboxylesterase 2 Homo sapiens 56-60 24988246-3 2014 Polymorphisms of the CES1 gene have been reported to affect the metabolism of dabigatran etexilate, methylphenidate, oseltamivir, imidapril, and clopidogrel, whereas variants of the CES2 gene have been found to affect aspirin and irinotecan. Aspirin 218-225 carboxylesterase 2 Homo sapiens 182-186 24988246-3 2014 Polymorphisms of the CES1 gene have been reported to affect the metabolism of dabigatran etexilate, methylphenidate, oseltamivir, imidapril, and clopidogrel, whereas variants of the CES2 gene have been found to affect aspirin and irinotecan. Irinotecan 230-240 carboxylesterase 2 Homo sapiens 182-186 23756919-8 2013 There was a strong correlation between hepatic CES-2 expression and activation of irinotecan (r (2) = 0.96, p < 0.001). Irinotecan 82-92 carboxylesterase 2 Homo sapiens 47-52 24195516-2 2014 The metabolism of CPT-11 is mainly controlled by carboxy-lesterase (CES), UDP-glucuronosyltransferase 1A (UGT1A), and beta-glucuronidase (GUSB). Irinotecan 18-24 carboxylesterase 2 Homo sapiens 49-66 23978563-7 2013 Pharmacokinetic approaches use cocaine-metabolizing enzymes, such as butyrylcholinesterase (BChE), cocaine hydrolase (CocH), and bacterial cocaine esterase (CocE). Cocaine 31-38 carboxylesterase 2 Homo sapiens 157-161 23535809-7 2013 ICE tended to lower the rating of perceived exertion (RPE, 12.9 +- 0.6, p = .05) and improve thermal comfort (TC, 4.5 +- 0.2; p = .01) vs. CON (13.8 +- 1.0 and 5.2 +- 0.2 respectively). Technetium 110-112 carboxylesterase 2 Homo sapiens 0-3 23937546-3 2013 In this paper, we investigate the nucleation of ice in nanoscale water films using molecular dynamics simulations. Water 65-70 carboxylesterase 2 Homo sapiens 48-51 23532626-5 2013 Changing regimen due to failure of first salvage therapy, 12 patients initially receiving ICE still achieved an OR of 58 % (33 % CR, 25 % PR) with DexaBEAM as second salvage therapy, whereas in three patients receiving ICE after DexaBEAM failure, only one achieved an OR (1 PR). Chromium 129-131 carboxylesterase 2 Homo sapiens 90-93 23726867-6 2013 Up-regulation of metabolic enzyme genes provided evidence for the involvement of phase I (CYP1A1, CYP1B1, ALDH1A2 and CES2) and phase II (UGT1A6, UGT1A1, NAT1 and GSTM3) enzymes in the detoxification response and potential activation of CYN. cylindrospermopsin 237-240 carboxylesterase 2 Homo sapiens 118-122 23756919-10 2013 Hepatic CES-2 mediated activation of irinotecan clearly correlated with tumour replacement by fibrosis (r (2) = 0.54, p = 0.01). Irinotecan 37-47 carboxylesterase 2 Homo sapiens 8-13 23239178-8 2013 It is noteworthy that CES1 converts DABE to M1 while CES2 mediates the conversion of DABE to M2. Dabigatran 85-89 carboxylesterase 2 Homo sapiens 53-57 23530020-4 2013 Our experiments revealed that prilocaine was hydrolyzed by recombinant human carboxylesterase (CES) 1A and CES2, whereas lidocaine was hydrolyzed by only human CES1A. Prilocaine 30-40 carboxylesterase 2 Homo sapiens 107-111 23471941-0 2013 Relationship between CES2 genetic variations and rifampicin metabolism. Rifampin 49-59 carboxylesterase 2 Homo sapiens 21-25 23471941-11 2013 CONCLUSIONS: Variations in CES2, especially c.-2263A > G in the promoter region, may alter rifampicin metabolism by affecting expression of the gene. Rifampin 94-104 carboxylesterase 2 Homo sapiens 27-31 23373735-0 2013 Regulation of carboxylesterase-2 expression by p53 family proteins and enhanced anti-cancer activities among 5-fluorouracil, irinotecan and doxazolidine prodrug. Fluorouracil 109-123 carboxylesterase 2 Homo sapiens 14-32 23373735-0 2013 Regulation of carboxylesterase-2 expression by p53 family proteins and enhanced anti-cancer activities among 5-fluorouracil, irinotecan and doxazolidine prodrug. Irinotecan 125-135 carboxylesterase 2 Homo sapiens 14-32 23373735-0 2013 Regulation of carboxylesterase-2 expression by p53 family proteins and enhanced anti-cancer activities among 5-fluorouracil, irinotecan and doxazolidine prodrug. doxazolidine 140-152 carboxylesterase 2 Homo sapiens 14-32 23373735-3 2013 Irinotecan and many others such as PPD (pentyl carbamate of p-aminobenzyl carbamate of doxazolidine) require activation by carboxylesterase-2 (CES2). Irinotecan 0-10 carboxylesterase 2 Homo sapiens 123-141 23373735-3 2013 Irinotecan and many others such as PPD (pentyl carbamate of p-aminobenzyl carbamate of doxazolidine) require activation by carboxylesterase-2 (CES2). Irinotecan 0-10 carboxylesterase 2 Homo sapiens 143-147 23373735-3 2013 Irinotecan and many others such as PPD (pentyl carbamate of p-aminobenzyl carbamate of doxazolidine) require activation by carboxylesterase-2 (CES2). Pentyl carbamate 40-56 carboxylesterase 2 Homo sapiens 123-141 23373735-3 2013 Irinotecan and many others such as PPD (pentyl carbamate of p-aminobenzyl carbamate of doxazolidine) require activation by carboxylesterase-2 (CES2). Pentyl carbamate 40-56 carboxylesterase 2 Homo sapiens 143-147 23373735-3 2013 Irinotecan and many others such as PPD (pentyl carbamate of p-aminobenzyl carbamate of doxazolidine) require activation by carboxylesterase-2 (CES2). p-aminobenzyl carbamate 60-83 carboxylesterase 2 Homo sapiens 123-141 23373735-3 2013 Irinotecan and many others such as PPD (pentyl carbamate of p-aminobenzyl carbamate of doxazolidine) require activation by carboxylesterase-2 (CES2). p-aminobenzyl carbamate 60-83 carboxylesterase 2 Homo sapiens 143-147 23373735-3 2013 Irinotecan and many others such as PPD (pentyl carbamate of p-aminobenzyl carbamate of doxazolidine) require activation by carboxylesterase-2 (CES2). doxazolidine 87-99 carboxylesterase 2 Homo sapiens 123-141 23373735-3 2013 Irinotecan and many others such as PPD (pentyl carbamate of p-aminobenzyl carbamate of doxazolidine) require activation by carboxylesterase-2 (CES2). doxazolidine 87-99 carboxylesterase 2 Homo sapiens 143-147 23373735-4 2013 5-FU, on the other hand, reportedly induces CES2 in colorectal tumour lines. Fluorouracil 0-4 carboxylesterase 2 Homo sapiens 44-48 23523394-4 2013 We present the case of a successful PMBV guided exclusively by ICE. pmbv 36-40 carboxylesterase 2 Homo sapiens 63-66 23325581-0 2013 Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells. gemcitabine 51-62 carboxylesterase 2 Homo sapiens 6-24 23325581-0 2013 Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells. LY2334737 64-73 carboxylesterase 2 Homo sapiens 6-24 23325581-9 2013 RESULTS: Of 3 human CES isozymes tested, only CES2 hydrolyzed LY2334737. LY2334737 62-71 carboxylesterase 2 Homo sapiens 46-50 23325581-10 2013 Five cell lines that express CES2 responded to LY2334737 treatment. LY2334737 47-56 carboxylesterase 2 Homo sapiens 29-33 23325581-11 2013 LY2334737 was less cytotoxic to a SK-OV-3 CES2 knockdown than parental cells. LY2334737 0-9 carboxylesterase 2 Homo sapiens 42-46 23325581-13 2013 Bystander studies showed statistically greater PC-3-GFP growth inhibition by LY2334737 when cells were cocultured with CES2 and not mock transfectants. LY2334737 77-86 carboxylesterase 2 Homo sapiens 119-123 23325581-14 2013 Oral treatment of xenograft models with 3.2 mg/kg LY2334737 once a day for 21 days showed greater tumor growth inhibition of CES2 transfectant than the mock transfectant (P <= 0.001). LY2334737 50-59 carboxylesterase 2 Homo sapiens 125-129 23325581-15 2013 CONCLUSIONS: CES2 is responsible for the slow hydrolysis of LY2334737. LY2334737 60-69 carboxylesterase 2 Homo sapiens 13-17 22446793-3 2013 CES2 secretion to the media was achieved by the simple addition of an in-frame C-terminal 10x histidine tag (CES2-10xHis) without the need of addition of extra N-terminal signalling sequences or the mutation or deletion of the C-terminal HTEL motif responsible for retaining the protein in the lumen of endoplasmic reticulum. Histidine 94-103 carboxylesterase 2 Homo sapiens 0-4 22446793-3 2013 CES2 secretion to the media was achieved by the simple addition of an in-frame C-terminal 10x histidine tag (CES2-10xHis) without the need of addition of extra N-terminal signalling sequences or the mutation or deletion of the C-terminal HTEL motif responsible for retaining the protein in the lumen of endoplasmic reticulum. Histidine 94-103 carboxylesterase 2 Homo sapiens 109-113 23386702-3 2013 OBJECTIVE: This study explores the ability of acyl glucuronides to act as substrates or inhibitors of human carboxylesterases 1 (hCES1) and 2 (hCES2). acyl glucuronides 46-63 carboxylesterase 2 Homo sapiens 143-148 23371859-13 2013 Elevated CES2 or ENT1 expression may enhance LY2334737 tumor response. LY2334737 45-54 carboxylesterase 2 Homo sapiens 9-13 23480903-1 2013 BACKGROUND/PURPOSE: Human carboxylesterase 2 (CES2) is the key enzyme for metabolic activation of irinotecan (CPT-11). Irinotecan 98-108 carboxylesterase 2 Homo sapiens 26-44 23480903-1 2013 BACKGROUND/PURPOSE: Human carboxylesterase 2 (CES2) is the key enzyme for metabolic activation of irinotecan (CPT-11). Irinotecan 98-108 carboxylesterase 2 Homo sapiens 46-50 23480903-1 2013 BACKGROUND/PURPOSE: Human carboxylesterase 2 (CES2) is the key enzyme for metabolic activation of irinotecan (CPT-11). Irinotecan 110-116 carboxylesterase 2 Homo sapiens 26-44 23480903-1 2013 BACKGROUND/PURPOSE: Human carboxylesterase 2 (CES2) is the key enzyme for metabolic activation of irinotecan (CPT-11). Irinotecan 110-116 carboxylesterase 2 Homo sapiens 46-50 23480903-8 2013 RESULTS: CES2 RNA expression was observed in neuroblastoma cells, and its expression in neuroblastoma cell lines was positively correlated with sensitivity to CPT-11 and apoptosis after CPT-11 exposure in vitro. Irinotecan 159-165 carboxylesterase 2 Homo sapiens 9-13 23480903-8 2013 RESULTS: CES2 RNA expression was observed in neuroblastoma cells, and its expression in neuroblastoma cell lines was positively correlated with sensitivity to CPT-11 and apoptosis after CPT-11 exposure in vitro. Irinotecan 186-192 carboxylesterase 2 Homo sapiens 9-13 23239178-9 2013 M1 and M2 were further metabolized to DAB by CES2 and CES1, respectively. Dabigatran 38-41 carboxylesterase 2 Homo sapiens 45-49 23648675-1 2013 Human carboxylesterase (CES) 1A and CES2, two major forms of human CES, dominate the pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11). imidapril 127-136 carboxylesterase 2 Homo sapiens 36-40 23161167-3 2013 A human corneal epithelial cell line (HCE-2) was treated with sodium hydroxide before incubation with low-molecular-weight HA (LMW-HA, 127 kDa) or high-molecular-weight HA (HMW-HA, 1525 kDa). Sodium Hydroxide 62-78 carboxylesterase 2 Homo sapiens 38-43 23648675-1 2013 Human carboxylesterase (CES) 1A and CES2, two major forms of human CES, dominate the pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11). Irinotecan 141-151 carboxylesterase 2 Homo sapiens 36-40 23648675-1 2013 Human carboxylesterase (CES) 1A and CES2, two major forms of human CES, dominate the pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11). Irinotecan 153-159 carboxylesterase 2 Homo sapiens 36-40 23648675-9 2013 The enzyme hydrolase activity of recombinant CES2 was substantially inhibited by diltiazem and verapamil (K(i) = 0.25 +- 0.02 and 3.84 +- 0.99 microM, respectively). Diltiazem 81-90 carboxylesterase 2 Homo sapiens 45-49 23648675-9 2013 The enzyme hydrolase activity of recombinant CES2 was substantially inhibited by diltiazem and verapamil (K(i) = 0.25 +- 0.02 and 3.84 +- 0.99 microM, respectively). Verapamil 95-104 carboxylesterase 2 Homo sapiens 45-49 23648675-10 2013 Hence, diltiazem, verapamil, nitrendipine and telmisartan may attenuate the drug efficacy of catalyzed prodrugs by changing the activities of CES1A1 and CES2. Diltiazem 7-16 carboxylesterase 2 Homo sapiens 153-157 23648675-10 2013 Hence, diltiazem, verapamil, nitrendipine and telmisartan may attenuate the drug efficacy of catalyzed prodrugs by changing the activities of CES1A1 and CES2. Verapamil 18-27 carboxylesterase 2 Homo sapiens 153-157 23648675-10 2013 Hence, diltiazem, verapamil, nitrendipine and telmisartan may attenuate the drug efficacy of catalyzed prodrugs by changing the activities of CES1A1 and CES2. Nitrendipine 29-41 carboxylesterase 2 Homo sapiens 153-157 23648675-10 2013 Hence, diltiazem, verapamil, nitrendipine and telmisartan may attenuate the drug efficacy of catalyzed prodrugs by changing the activities of CES1A1 and CES2. Telmisartan 46-57 carboxylesterase 2 Homo sapiens 153-157 22446520-0 2012 Contributions of arylacetamide deacetylase and carboxylesterase 2 to flutamide hydrolysis in human liver. Flutamide 69-78 carboxylesterase 2 Homo sapiens 47-65 22943979-5 2012 We report the kinetic rate constants for inhibition of human recombinant CES1 and CES2 by URB597 and JZL184. cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester 90-96 carboxylesterase 2 Homo sapiens 82-86 22943979-7 2012 However, k(inact)/K(i) for inhibition of CES2 by JZL184 and URB597 were significantly different [2.3 (+-1.3) x 10(2) M(-1) s(-1) and 3.9 (+-1.0) x 10(3) M(-1) s(-1), respectively]. JZL 184 49-55 carboxylesterase 2 Homo sapiens 41-45 22943979-7 2012 However, k(inact)/K(i) for inhibition of CES2 by JZL184 and URB597 were significantly different [2.3 (+-1.3) x 10(2) M(-1) s(-1) and 3.9 (+-1.0) x 10(3) M(-1) s(-1), respectively]. cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester 60-66 carboxylesterase 2 Homo sapiens 41-45 22943979-8 2012 Rates of inhibition of CES1 and CES2 by URB597 were similar; however, CES1 and MAGL were more potently inhibited by JZL184 than CES2. cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester 40-46 carboxylesterase 2 Homo sapiens 32-36 22525521-7 2012 In contrast, procaine hydrolysis rates, a drug metabolized by CES2 but not CES1, were much less variant (3-fold). Procaine 13-21 carboxylesterase 2 Homo sapiens 62-66 22446520-7 2012 In the present study, we found that recombinant carboxylesterase (CES) 2 could hydrolyze flutamide at low concentrations of flutamide. Flutamide 89-98 carboxylesterase 2 Homo sapiens 66-72 22446520-7 2012 In the present study, we found that recombinant carboxylesterase (CES) 2 could hydrolyze flutamide at low concentrations of flutamide. Flutamide 124-133 carboxylesterase 2 Homo sapiens 66-72 22446520-8 2012 In the inhibition assay, the flutamide hydrolase activities at a flutamide concentration of 5 muM in human liver and jejunum microsomes were strongly inhibited by a selective CES2 inhibitor, 10 muM loperamide, with the residual activities of 22.9 +- 3.5 and 18.6 +- 0.7%, respectively. Flutamide 29-38 carboxylesterase 2 Homo sapiens 175-179 22446520-8 2012 In the inhibition assay, the flutamide hydrolase activities at a flutamide concentration of 5 muM in human liver and jejunum microsomes were strongly inhibited by a selective CES2 inhibitor, 10 muM loperamide, with the residual activities of 22.9 +- 3.5 and 18.6 +- 0.7%, respectively. Loperamide 198-208 carboxylesterase 2 Homo sapiens 175-179 22446520-9 2012 These results suggest that CES2 is also involved in the flutamide hydrolysis in human tissues. Flutamide 56-65 carboxylesterase 2 Homo sapiens 27-31 22446520-10 2012 Using six individual human livers, the contributions of AADAC and CES2 to flutamide hydrolysis were estimated by using the relative activity factor. Flutamide 74-83 carboxylesterase 2 Homo sapiens 66-70 22446520-11 2012 The relative contribution of CES2 was approximately 75 to 99% at the concentration of 5 muM flutamide. Flutamide 92-101 carboxylesterase 2 Homo sapiens 29-33 22446520-13 2012 Thus, CES2, rather than AADAC, largely contributed to the flutamide hydrolysis in clinical therapeutics. Flutamide 58-67 carboxylesterase 2 Homo sapiens 6-10 21951919-7 2012 Interestingly, inhibition of CES by bis(p-nitrophenyl) phosphate (BNPP) and CES2 by loperamide enhanced the cytotoxicity of BisGMA and DBA. Loperamide 84-94 carboxylesterase 2 Homo sapiens 76-80 22293119-6 2012 These results strongly suggest that CES1, rather than CES2, is the principal enzyme responsible for the hydrolysis of oxybutynin in human liver. oxybutynin 118-128 carboxylesterase 2 Homo sapiens 54-58 22404344-1 2012 Cocaine esterase (CocE) is the most efficient cocaine-metabolizing enzyme tested in vivo to date, displaying a rapid clearance of cocaine and a robust protection against cocaine"s toxicity. Cocaine 46-53 carboxylesterase 2 Homo sapiens 0-16 22404344-1 2012 Cocaine esterase (CocE) is the most efficient cocaine-metabolizing enzyme tested in vivo to date, displaying a rapid clearance of cocaine and a robust protection against cocaine"s toxicity. Cocaine 46-53 carboxylesterase 2 Homo sapiens 18-22 22385120-0 2012 Cocaine esterase-cocaine binding process and the free energy profiles by molecular dynamics and potential of mean force simulations. Cocaine 17-24 carboxylesterase 2 Homo sapiens 0-16 22385120-1 2012 The combined molecular dynamics (MD) and potential of mean force (PMF) simulations have been performed to determine the free energy profiles for the binding process of (-)-cocaine interacting with wild-type cocaine esterase (CocE) and its mutants (T172R/G173Q and L119A/L169K/G173Q). Cocaine 168-179 carboxylesterase 2 Homo sapiens 207-223 22385120-1 2012 The combined molecular dynamics (MD) and potential of mean force (PMF) simulations have been performed to determine the free energy profiles for the binding process of (-)-cocaine interacting with wild-type cocaine esterase (CocE) and its mutants (T172R/G173Q and L119A/L169K/G173Q). Cocaine 168-179 carboxylesterase 2 Homo sapiens 225-229 21951919-7 2012 Interestingly, inhibition of CES by bis(p-nitrophenyl) phosphate (BNPP) and CES2 by loperamide enhanced the cytotoxicity of BisGMA and DBA. bisgma 124-130 carboxylesterase 2 Homo sapiens 76-80 21951919-11 2012 Expression of CES, especially CES2, in dental pulp cells can be an adaptive response to protect dental pulp against BisGMA-induced cytotoxicity and prostanoid release. bisgma 116-122 carboxylesterase 2 Homo sapiens 30-34 21951919-11 2012 Expression of CES, especially CES2, in dental pulp cells can be an adaptive response to protect dental pulp against BisGMA-induced cytotoxicity and prostanoid release. Prostaglandins 148-158 carboxylesterase 2 Homo sapiens 30-34 22605930-3 2012 METHODS: HCE-2 cells were exposed to the commercial eye drops Travatan, Systane Ultra, Xalatan, and the preservative BAK. Travoprost 62-70 carboxylesterase 2 Homo sapiens 9-14 22525550-5 2012 After induction chemotherapy with ICE (Ifosfamide, Carboplatin, Etoposide), she developed neutropenia and high fever without apparent infective foci. Ifosfamide 39-49 carboxylesterase 2 Homo sapiens 34-37 22525550-5 2012 After induction chemotherapy with ICE (Ifosfamide, Carboplatin, Etoposide), she developed neutropenia and high fever without apparent infective foci. Carboplatin 51-62 carboxylesterase 2 Homo sapiens 34-37 22525550-5 2012 After induction chemotherapy with ICE (Ifosfamide, Carboplatin, Etoposide), she developed neutropenia and high fever without apparent infective foci. Etoposide 64-73 carboxylesterase 2 Homo sapiens 34-37 21989950-5 2012 Brivanib alaninate was efficiently converted to brivanib in the presence of either human carboxylesterase 1 or carboxylesterase 2. brivanib 0-18 carboxylesterase 2 Homo sapiens 111-129 21989950-5 2012 Brivanib alaninate was efficiently converted to brivanib in the presence of either human carboxylesterase 1 or carboxylesterase 2. brivanib 48-56 carboxylesterase 2 Homo sapiens 111-129 22605930-8 2012 BAK at 0.02% rather than at 0.001% concentration evoked total cell death signs on HCE-2 cells. Benzalkonium Compounds 0-3 carboxylesterase 2 Homo sapiens 82-87 22605930-3 2012 METHODS: HCE-2 cells were exposed to the commercial eye drops Travatan, Systane Ultra, Xalatan, and the preservative BAK. systane ultra 72-85 carboxylesterase 2 Homo sapiens 9-14 22605930-3 2012 METHODS: HCE-2 cells were exposed to the commercial eye drops Travatan, Systane Ultra, Xalatan, and the preservative BAK. Latanoprost 87-94 carboxylesterase 2 Homo sapiens 9-14 22605930-3 2012 METHODS: HCE-2 cells were exposed to the commercial eye drops Travatan, Systane Ultra, Xalatan, and the preservative BAK. Benzalkonium Compounds 117-120 carboxylesterase 2 Homo sapiens 9-14 22100607-8 2012 Here, we determined the potency of inhibition (IC(50) values; 15 min preincubation, enzyme and inhibitor) of recombinant CES1, CES2, and MGL by chlorpyrifos oxon, paraoxon and methyl paraoxon. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 144-161 carboxylesterase 2 Homo sapiens 127-131 22100607-9 2012 The order of potency for these three oxons with CES1, CES2, and MGL was chlorpyrifos oxon>paraoxon>methyl paraoxon, although the difference in potency for chlorpyrifos oxon with CES1 and CES2 did not reach statistical significance. Paraoxon 93-101 carboxylesterase 2 Homo sapiens 54-58 22100607-8 2012 Here, we determined the potency of inhibition (IC(50) values; 15 min preincubation, enzyme and inhibitor) of recombinant CES1, CES2, and MGL by chlorpyrifos oxon, paraoxon and methyl paraoxon. Paraoxon 163-171 carboxylesterase 2 Homo sapiens 127-131 22100607-9 2012 The order of potency for these three oxons with CES1, CES2, and MGL was chlorpyrifos oxon>paraoxon>methyl paraoxon, although the difference in potency for chlorpyrifos oxon with CES1 and CES2 did not reach statistical significance. Paraoxon 112-120 carboxylesterase 2 Homo sapiens 54-58 21540359-0 2011 Characterization of recombinant human carboxylesterases: fluorescein diacetate as a probe substrate for human carboxylesterase 2. diacetylfluorescein 57-78 carboxylesterase 2 Homo sapiens 110-128 22100607-10 2012 We also determined the bimolecular rate constants (k(inact)/K(I)) for the covalent reaction of chlorpyrifos oxon, paraoxon and methyl paraoxon with CES1 and CES2. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 95-112 carboxylesterase 2 Homo sapiens 157-161 22100607-10 2012 We also determined the bimolecular rate constants (k(inact)/K(I)) for the covalent reaction of chlorpyrifos oxon, paraoxon and methyl paraoxon with CES1 and CES2. Paraoxon 114-122 carboxylesterase 2 Homo sapiens 157-161 22100607-10 2012 We also determined the bimolecular rate constants (k(inact)/K(I)) for the covalent reaction of chlorpyrifos oxon, paraoxon and methyl paraoxon with CES1 and CES2. Paraoxon 134-142 carboxylesterase 2 Homo sapiens 157-161 22100607-11 2012 Consistent with the results for the IC(50) values, the order of reactivity for each of the three oxons with CES1 and CES2 was chlorpyrifos oxon>paraoxon>methyl paraoxon. Chlorpyrifos 126-138 carboxylesterase 2 Homo sapiens 117-121 22100607-12 2012 The bimolecular rate constant for the reaction of chlorpyrifos oxon with MGL was also determined and was less than the values determined for chlorpyrifos oxon with CES1 and CES2 respectively. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 50-67 carboxylesterase 2 Homo sapiens 173-177 21850310-6 2011 They include: (1) above 140 K protons move readily within and on the surface of ice while hydroxide ions are orders-of-magnitude less mobile, (2) whether generated by dissociation of HCl buried in ice, during neat ice particle growth, or at platinum-ice interfaces, interior protons move to and apparently collect at the ice-vacuum interface, and (3) proton activity and populations are orders-of-magnitude greater at the surface of ice films and free-standing ice particles than in the interior. Hydrochloric Acid 183-186 carboxylesterase 2 Homo sapiens 197-200 21850310-6 2011 They include: (1) above 140 K protons move readily within and on the surface of ice while hydroxide ions are orders-of-magnitude less mobile, (2) whether generated by dissociation of HCl buried in ice, during neat ice particle growth, or at platinum-ice interfaces, interior protons move to and apparently collect at the ice-vacuum interface, and (3) proton activity and populations are orders-of-magnitude greater at the surface of ice films and free-standing ice particles than in the interior. Hydrochloric Acid 183-186 carboxylesterase 2 Homo sapiens 197-200 21850310-6 2011 They include: (1) above 140 K protons move readily within and on the surface of ice while hydroxide ions are orders-of-magnitude less mobile, (2) whether generated by dissociation of HCl buried in ice, during neat ice particle growth, or at platinum-ice interfaces, interior protons move to and apparently collect at the ice-vacuum interface, and (3) proton activity and populations are orders-of-magnitude greater at the surface of ice films and free-standing ice particles than in the interior. Hydrochloric Acid 183-186 carboxylesterase 2 Homo sapiens 197-200 21840303-1 2011 In the liver, carboxylesterase (CES) converts irinotecan (CPT-11) to its active metabolite SN-38, which exerts anticancer effects. Irinotecan 46-56 carboxylesterase 2 Homo sapiens 14-30 21840303-1 2011 In the liver, carboxylesterase (CES) converts irinotecan (CPT-11) to its active metabolite SN-38, which exerts anticancer effects. Irinotecan 58-64 carboxylesterase 2 Homo sapiens 14-30 21840303-1 2011 In the liver, carboxylesterase (CES) converts irinotecan (CPT-11) to its active metabolite SN-38, which exerts anticancer effects. Irinotecan 91-96 carboxylesterase 2 Homo sapiens 14-30 21840303-9 2011 HGF suppressed the cytotoxicity of CPT-11 by decreasing intracellular SN-38 levels that resulted from a decrease in CES2 and an increase in UGT1A1. Irinotecan 35-41 carboxylesterase 2 Homo sapiens 116-120 21840303-9 2011 HGF suppressed the cytotoxicity of CPT-11 by decreasing intracellular SN-38 levels that resulted from a decrease in CES2 and an increase in UGT1A1. Irinotecan 70-75 carboxylesterase 2 Homo sapiens 116-120 21918037-7 2011 Loperamide, a selective human CES2 inhibitor, was also found to be a CES2-selective inhibitor in both dog and monkey. Loperamide 0-10 carboxylesterase 2 Homo sapiens 30-34 21918037-7 2011 Loperamide, a selective human CES2 inhibitor, was also found to be a CES2-selective inhibitor in both dog and monkey. Loperamide 0-10 carboxylesterase 2 Homo sapiens 69-73 21850310-6 2011 They include: (1) above 140 K protons move readily within and on the surface of ice while hydroxide ions are orders-of-magnitude less mobile, (2) whether generated by dissociation of HCl buried in ice, during neat ice particle growth, or at platinum-ice interfaces, interior protons move to and apparently collect at the ice-vacuum interface, and (3) proton activity and populations are orders-of-magnitude greater at the surface of ice films and free-standing ice particles than in the interior. Hydrochloric Acid 183-186 carboxylesterase 2 Homo sapiens 197-200 21850310-6 2011 They include: (1) above 140 K protons move readily within and on the surface of ice while hydroxide ions are orders-of-magnitude less mobile, (2) whether generated by dissociation of HCl buried in ice, during neat ice particle growth, or at platinum-ice interfaces, interior protons move to and apparently collect at the ice-vacuum interface, and (3) proton activity and populations are orders-of-magnitude greater at the surface of ice films and free-standing ice particles than in the interior. Hydrochloric Acid 183-186 carboxylesterase 2 Homo sapiens 197-200 21850310-6 2011 They include: (1) above 140 K protons move readily within and on the surface of ice while hydroxide ions are orders-of-magnitude less mobile, (2) whether generated by dissociation of HCl buried in ice, during neat ice particle growth, or at platinum-ice interfaces, interior protons move to and apparently collect at the ice-vacuum interface, and (3) proton activity and populations are orders-of-magnitude greater at the surface of ice films and free-standing ice particles than in the interior. Hydrochloric Acid 183-186 carboxylesterase 2 Homo sapiens 197-200 21540359-4 2011 With 4-nitrophenyl acetate (4-NPA) as the probe substrate, the K(m) values of recombinant CES1-b and CES2 matched those of human liver microsomes (HLM) and human intestinal microsomes (HIM) with approximately 200 and 180 muM, respectively. 4-nitrophenyl acetate 5-26 carboxylesterase 2 Homo sapiens 101-105 22521011-9 2011 All but one patient were treated with ICE (Ifosfamide, Carboplatin, Etoposide). Ifosfamide 43-53 carboxylesterase 2 Homo sapiens 38-41 21486046-1 2011 First-principles quantum mechanical/molecular mechanical free energy calculations have been performed to examine the catalytic mechanism for cocaine esterase (CocE)-catalyzed hydrolysis of (+)-cocaine in comparison with CocE-catalyzed hydrolysis of (-)-cocaine. Cocaine 249-260 carboxylesterase 2 Homo sapiens 220-224 21373712-1 2011 Cocaine esterase (CocE) has been known as the most efficient native enzyme for metabolizing naturally occurring cocaine. Cocaine 112-119 carboxylesterase 2 Homo sapiens 0-16 21373712-1 2011 Cocaine esterase (CocE) has been known as the most efficient native enzyme for metabolizing naturally occurring cocaine. Cocaine 112-119 carboxylesterase 2 Homo sapiens 18-22 21486046-1 2011 First-principles quantum mechanical/molecular mechanical free energy calculations have been performed to examine the catalytic mechanism for cocaine esterase (CocE)-catalyzed hydrolysis of (+)-cocaine in comparison with CocE-catalyzed hydrolysis of (-)-cocaine. Cocaine 189-200 carboxylesterase 2 Homo sapiens 141-157 22152246-10 2011 In T-ABZ group the short-term curative rates were 50.0% (15/30), 8.8% (8/91) and 33.3% (7/21) respectively in CE1, CE2, and CE3, the short-term total effective rates were 56.7% (17/30), 35.2% (32/91) and 61.9% (13/21) respectively in CE1, CE2, and CE3. t-abz 3-8 carboxylesterase 2 Homo sapiens 115-118 22152246-10 2011 In T-ABZ group the short-term curative rates were 50.0% (15/30), 8.8% (8/91) and 33.3% (7/21) respectively in CE1, CE2, and CE3, the short-term total effective rates were 56.7% (17/30), 35.2% (32/91) and 61.9% (13/21) respectively in CE1, CE2, and CE3. t-abz 3-8 carboxylesterase 2 Homo sapiens 239-242 21499642-0 2011 Ice-mediated coating of macroporous cryogels by carbon nanotubes: a concept towards electrically conducting nanocomposites. Carbon 48-54 carboxylesterase 2 Homo sapiens 0-3 21486046-1 2011 First-principles quantum mechanical/molecular mechanical free energy calculations have been performed to examine the catalytic mechanism for cocaine esterase (CocE)-catalyzed hydrolysis of (+)-cocaine in comparison with CocE-catalyzed hydrolysis of (-)-cocaine. Cocaine 189-200 carboxylesterase 2 Homo sapiens 159-163 21486046-3 2011 The first reaction step of deacylation of (+)-cocaine, which is identical to that of (-)-cocaine, is rate-determining, indicating that CocE-catalyzed hydrolyses of (+)- and (-)-cocaine have a common rate-determining step. Cocaine 42-53 carboxylesterase 2 Homo sapiens 135-139 21486046-3 2011 The first reaction step of deacylation of (+)-cocaine, which is identical to that of (-)-cocaine, is rate-determining, indicating that CocE-catalyzed hydrolyses of (+)- and (-)-cocaine have a common rate-determining step. Cocaine 85-96 carboxylesterase 2 Homo sapiens 135-139 21486046-4 2011 The computational results predict that the catalytic rate constant of CocE against (+)-cocaine should be the same as that of CocE against (-)-cocaine, in contrast with the remarkable difference between human butyrylcholinesterase-catalyzed hydrolyses of (+)- and (-)-cocaine. Cocaine 83-94 carboxylesterase 2 Homo sapiens 70-74 21486046-4 2011 The computational results predict that the catalytic rate constant of CocE against (+)-cocaine should be the same as that of CocE against (-)-cocaine, in contrast with the remarkable difference between human butyrylcholinesterase-catalyzed hydrolyses of (+)- and (-)-cocaine. Cocaine 83-94 carboxylesterase 2 Homo sapiens 125-129 21486046-4 2011 The computational results predict that the catalytic rate constant of CocE against (+)-cocaine should be the same as that of CocE against (-)-cocaine, in contrast with the remarkable difference between human butyrylcholinesterase-catalyzed hydrolyses of (+)- and (-)-cocaine. Cocaine 138-149 carboxylesterase 2 Homo sapiens 125-129 21486046-4 2011 The computational results predict that the catalytic rate constant of CocE against (+)-cocaine should be the same as that of CocE against (-)-cocaine, in contrast with the remarkable difference between human butyrylcholinesterase-catalyzed hydrolyses of (+)- and (-)-cocaine. Cocaine 263-274 carboxylesterase 2 Homo sapiens 70-74 21486046-4 2011 The computational results predict that the catalytic rate constant of CocE against (+)-cocaine should be the same as that of CocE against (-)-cocaine, in contrast with the remarkable difference between human butyrylcholinesterase-catalyzed hydrolyses of (+)- and (-)-cocaine. Cocaine 263-274 carboxylesterase 2 Homo sapiens 125-129 21486046-5 2011 The prediction has been confirmed by experimental kinetic analysis on CocE-catalyzed hydrolysis of (+)-cocaine in comparison with CocE-catalyzed hydrolysis of (-)-cocaine. Cocaine 99-110 carboxylesterase 2 Homo sapiens 70-74 21486046-5 2011 The prediction has been confirmed by experimental kinetic analysis on CocE-catalyzed hydrolysis of (+)-cocaine in comparison with CocE-catalyzed hydrolysis of (-)-cocaine. Cocaine 99-110 carboxylesterase 2 Homo sapiens 130-134 21486046-5 2011 The prediction has been confirmed by experimental kinetic analysis on CocE-catalyzed hydrolysis of (+)-cocaine in comparison with CocE-catalyzed hydrolysis of (-)-cocaine. Cocaine 159-170 carboxylesterase 2 Homo sapiens 70-74 21486046-5 2011 The prediction has been confirmed by experimental kinetic analysis on CocE-catalyzed hydrolysis of (+)-cocaine in comparison with CocE-catalyzed hydrolysis of (-)-cocaine. Cocaine 159-170 carboxylesterase 2 Homo sapiens 130-134 21049984-8 2010 Furthermore, we show that CES1 and CES2 also efficiently hydrolyze PGE2-G and PGF2alpha-G. Dinoprostone 67-71 carboxylesterase 2 Homo sapiens 35-39 21237253-7 2011 In addition, being pretreated with LPS, HepG2 cells altered the cellular responsiveness to ester therapeutic agents, including clopidogrel (hydrolyzed by HCE1) and irinotecan (hydrolyzed by HCE2). Esters 91-96 carboxylesterase 2 Homo sapiens 190-194 21207966-2 2011 Taking the advantage of loperamide, a specific carboxylesterase 2 (CES2) inhibitor, and bis-p-nitrophenyl phosphate (BNPP), an irreversible CESs inhibitor, we propose for the first time a capillary electrophoresis (CE) method that enables detecting and distinguishing CES2 activity from other CESs in complex biological samples. Loperamide 24-34 carboxylesterase 2 Homo sapiens 67-71 21207966-2 2011 Taking the advantage of loperamide, a specific carboxylesterase 2 (CES2) inhibitor, and bis-p-nitrophenyl phosphate (BNPP), an irreversible CESs inhibitor, we propose for the first time a capillary electrophoresis (CE) method that enables detecting and distinguishing CES2 activity from other CESs in complex biological samples. bis(4-nitrophenyl)phosphate 117-121 carboxylesterase 2 Homo sapiens 268-272 25954121-7 2011 The coolant is a specially processed micro-particulate ice saline slurry, that can be easily pumped into a patient through surgical tubing, syringes, or minimally invasive surgical instruments. Sodium Chloride 59-65 carboxylesterase 2 Homo sapiens 55-58 25954121-8 2011 The device induces heterogeneous ice nucleation in a saline stream that has been super-cooled from room temperature to a temperature below the saline freezing point. Sodium Chloride 53-59 carboxylesterase 2 Homo sapiens 7-10 25954121-8 2011 The device induces heterogeneous ice nucleation in a saline stream that has been super-cooled from room temperature to a temperature below the saline freezing point. Sodium Chloride 143-149 carboxylesterase 2 Homo sapiens 7-10 21049984-4 2010 Here, we determined if two human CES isoforms, CES1 and CES2, hydrolyze the endocannabinoids 2-arachidonoylglycerol (2AG) and anandamide (AEA), and two prostaglandin glyceryl esters (PG-Gs), which are formed by COX-mediated oxygenation of 2AG. glyceryl 2-arachidonate 93-115 carboxylesterase 2 Homo sapiens 56-60 21049984-4 2010 Here, we determined if two human CES isoforms, CES1 and CES2, hydrolyze the endocannabinoids 2-arachidonoylglycerol (2AG) and anandamide (AEA), and two prostaglandin glyceryl esters (PG-Gs), which are formed by COX-mediated oxygenation of 2AG. anandamide 126-136 carboxylesterase 2 Homo sapiens 56-60 21049984-4 2010 Here, we determined if two human CES isoforms, CES1 and CES2, hydrolyze the endocannabinoids 2-arachidonoylglycerol (2AG) and anandamide (AEA), and two prostaglandin glyceryl esters (PG-Gs), which are formed by COX-mediated oxygenation of 2AG. anandamide 138-141 carboxylesterase 2 Homo sapiens 56-60 21049984-4 2010 Here, we determined if two human CES isoforms, CES1 and CES2, hydrolyze the endocannabinoids 2-arachidonoylglycerol (2AG) and anandamide (AEA), and two prostaglandin glyceryl esters (PG-Gs), which are formed by COX-mediated oxygenation of 2AG. prostaglandin glyceryl esters 152-181 carboxylesterase 2 Homo sapiens 56-60 21049984-4 2010 Here, we determined if two human CES isoforms, CES1 and CES2, hydrolyze the endocannabinoids 2-arachidonoylglycerol (2AG) and anandamide (AEA), and two prostaglandin glyceryl esters (PG-Gs), which are formed by COX-mediated oxygenation of 2AG. pg-gs 183-188 carboxylesterase 2 Homo sapiens 56-60 21237253-1 2011 Carboxylesterases constitute a class of enzymes that hydrolyze drugs containing such functional groups as carboxylic acid ester, amide, and thioester. carboxylic acid ester 106-127 carboxylesterase 2 Homo sapiens 0-17 21237253-1 2011 Carboxylesterases constitute a class of enzymes that hydrolyze drugs containing such functional groups as carboxylic acid ester, amide, and thioester. Amides 129-134 carboxylesterase 2 Homo sapiens 0-17 21237253-1 2011 Carboxylesterases constitute a class of enzymes that hydrolyze drugs containing such functional groups as carboxylic acid ester, amide, and thioester. Cy5-benzyl thioester 140-149 carboxylesterase 2 Homo sapiens 0-17 21237253-6 2011 Further study showed that both PDTC, a NF-kappaB inhibitor, and SB203580, a p38MAPK inhibitor, could abolish the repression of HCE1 and HCE2 mediated by LPS, but U0126, a selective ERK1/2 inhibitor, could not do so, suggesting the repression of HCE1 and HCE2 by LPS through the p38MAPK-NF-kappaB pathway. SB 203580 64-72 carboxylesterase 2 Homo sapiens 136-140 21237253-6 2011 Further study showed that both PDTC, a NF-kappaB inhibitor, and SB203580, a p38MAPK inhibitor, could abolish the repression of HCE1 and HCE2 mediated by LPS, but U0126, a selective ERK1/2 inhibitor, could not do so, suggesting the repression of HCE1 and HCE2 by LPS through the p38MAPK-NF-kappaB pathway. SB 203580 64-72 carboxylesterase 2 Homo sapiens 254-258 22099936-4 2011 The aim of this study is to evaluate the response rate of salvage chemotherapy by the ICE (Ifosfamide, Carboplatin, and Etoposide) regimen when administered to previously treated primary refractory or progressive high risk neuroblastoma patients. Ifosfamide 91-101 carboxylesterase 2 Homo sapiens 86-89 22099936-4 2011 The aim of this study is to evaluate the response rate of salvage chemotherapy by the ICE (Ifosfamide, Carboplatin, and Etoposide) regimen when administered to previously treated primary refractory or progressive high risk neuroblastoma patients. Carboplatin 103-114 carboxylesterase 2 Homo sapiens 86-89 22099936-4 2011 The aim of this study is to evaluate the response rate of salvage chemotherapy by the ICE (Ifosfamide, Carboplatin, and Etoposide) regimen when administered to previously treated primary refractory or progressive high risk neuroblastoma patients. Etoposide 120-129 carboxylesterase 2 Homo sapiens 86-89 21049984-5 2010 We show that recombinant CES1 and CES2 efficiently hydrolyze 2AG to arachidonic acid (AA) but not amide-containing AEA. Arachidonic Acid 68-84 carboxylesterase 2 Homo sapiens 34-38 21049984-8 2010 Furthermore, we show that CES1 and CES2 also efficiently hydrolyze PGE2-G and PGF2alpha-G. Dinoprost 78-87 carboxylesterase 2 Homo sapiens 35-39 21053990-3 2010 Prasugrel is converted to its active metabolite (Pras-AM; compound R-138727) in two sequential steps: (i) rapid and complete hydrolysis by intestinal human carboxylesterase-2 to form a thiolactone intermediate; and (ii) oxidation of the thiolactone by cytochrome P450 (CYP) enzymes in the gut and/or the liver. Prasugrel Hydrochloride 0-9 carboxylesterase 2 Homo sapiens 156-174 21053990-3 2010 Prasugrel is converted to its active metabolite (Pras-AM; compound R-138727) in two sequential steps: (i) rapid and complete hydrolysis by intestinal human carboxylesterase-2 to form a thiolactone intermediate; and (ii) oxidation of the thiolactone by cytochrome P450 (CYP) enzymes in the gut and/or the liver. Thiolactone 185-196 carboxylesterase 2 Homo sapiens 156-174 21189138-6 2010 The predominant human intestinal CES, hCE2, preferentially hydrolyzes prodrugs in which the alcohol group of a pharmacologically active molecule has been modified by the addition of a small acyl group. Alcohols 92-99 carboxylesterase 2 Homo sapiens 38-42 20810539-8 2010 7-Ethyl-10-[4-(1-piperidono)-1-piperidono]carbonyloxycamptothecin hydrolase activity by recombinant human CES2 was substantially inhibited by fenofibrate (K(i) = 0.04 +- 0.01 muM) as well as by simvastatin (0.67 +- 0.09 muM). -ethyl-10- 1-11 carboxylesterase 2 Homo sapiens 106-110 20810539-8 2010 7-Ethyl-10-[4-(1-piperidono)-1-piperidono]carbonyloxycamptothecin hydrolase activity by recombinant human CES2 was substantially inhibited by fenofibrate (K(i) = 0.04 +- 0.01 muM) as well as by simvastatin (0.67 +- 0.09 muM). Fenofibrate 142-153 carboxylesterase 2 Homo sapiens 106-110 20810539-8 2010 7-Ethyl-10-[4-(1-piperidono)-1-piperidono]carbonyloxycamptothecin hydrolase activity by recombinant human CES2 was substantially inhibited by fenofibrate (K(i) = 0.04 +- 0.01 muM) as well as by simvastatin (0.67 +- 0.09 muM). Simvastatin 194-205 carboxylesterase 2 Homo sapiens 106-110 20810539-10 2010 Thus, the inhibitory effects of the thiazolidinediones and fenofibrate on CES1A1 and CES2 were different. Thiazolidinediones 36-54 carboxylesterase 2 Homo sapiens 85-89 20810539-10 2010 Thus, the inhibitory effects of the thiazolidinediones and fenofibrate on CES1A1 and CES2 were different. Fenofibrate 59-70 carboxylesterase 2 Homo sapiens 85-89 20810539-11 2010 Some statins such as simvastatin and lovastatin, thiazolidinediones, and fenofibrate might attenuate the drug efficacy of prodrugs biotransformed by CES1A and CES2. Simvastatin 21-32 carboxylesterase 2 Homo sapiens 159-163 20810539-11 2010 Some statins such as simvastatin and lovastatin, thiazolidinediones, and fenofibrate might attenuate the drug efficacy of prodrugs biotransformed by CES1A and CES2. Lovastatin 37-47 carboxylesterase 2 Homo sapiens 159-163 20810539-11 2010 Some statins such as simvastatin and lovastatin, thiazolidinediones, and fenofibrate might attenuate the drug efficacy of prodrugs biotransformed by CES1A and CES2. Thiazolidinediones 49-67 carboxylesterase 2 Homo sapiens 159-163 20810539-11 2010 Some statins such as simvastatin and lovastatin, thiazolidinediones, and fenofibrate might attenuate the drug efficacy of prodrugs biotransformed by CES1A and CES2. Fenofibrate 73-84 carboxylesterase 2 Homo sapiens 159-163 20623318-3 2010 The present study was undertaken to develop a computational approach able to predict the hydrolysis of novel esters by human carboxylesterase hCES2. Esters 109-115 carboxylesterase 2 Homo sapiens 142-147 20436035-4 2010 We have recently reported the use of cocaine esterase (CocE) to accelerate the removal of systemic cocaine and to prevent cocaine-induced lethality. Cocaine 37-44 carboxylesterase 2 Homo sapiens 55-59 20649590-7 2010 However, cocaine, heroin and CPT-11 were all substrates for the intestinal CE, hiCE (CES2), as determined using both the recombinant protein and the tissue fractions. Cocaine 9-16 carboxylesterase 2 Homo sapiens 85-89 20649590-7 2010 However, cocaine, heroin and CPT-11 were all substrates for the intestinal CE, hiCE (CES2), as determined using both the recombinant protein and the tissue fractions. Heroin 18-24 carboxylesterase 2 Homo sapiens 85-89 20649590-7 2010 However, cocaine, heroin and CPT-11 were all substrates for the intestinal CE, hiCE (CES2), as determined using both the recombinant protein and the tissue fractions. Irinotecan 29-35 carboxylesterase 2 Homo sapiens 85-89 20436035-4 2010 We have recently reported the use of cocaine esterase (CocE) to accelerate the removal of systemic cocaine and to prevent cocaine-induced lethality. Cocaine 99-106 carboxylesterase 2 Homo sapiens 37-53 20436035-4 2010 We have recently reported the use of cocaine esterase (CocE) to accelerate the removal of systemic cocaine and to prevent cocaine-induced lethality. Cocaine 99-106 carboxylesterase 2 Homo sapiens 55-59 20436035-9 2010 The improved stability of these engineered CocE enzymes will have a profound influence on the use of this protein to combat cocaine-induced toxicity and addiction in humans. Cocaine 124-131 carboxylesterase 2 Homo sapiens 43-47 19857534-1 2010 Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been considered as a promising treatment strategy for cocaine overdose and addiction, as CocE is the most efficient native enzyme yet identified for metabolizing the naturally occurring cocaine. Cocaine 10-17 carboxylesterase 2 Homo sapiens 50-66 19857534-1 2010 Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been considered as a promising treatment strategy for cocaine overdose and addiction, as CocE is the most efficient native enzyme yet identified for metabolizing the naturally occurring cocaine. Cocaine 10-17 carboxylesterase 2 Homo sapiens 68-72 19857534-1 2010 Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been considered as a promising treatment strategy for cocaine overdose and addiction, as CocE is the most efficient native enzyme yet identified for metabolizing the naturally occurring cocaine. Cocaine 10-17 carboxylesterase 2 Homo sapiens 167-171 19857534-1 2010 Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been considered as a promising treatment strategy for cocaine overdose and addiction, as CocE is the most efficient native enzyme yet identified for metabolizing the naturally occurring cocaine. Cocaine 50-57 carboxylesterase 2 Homo sapiens 68-72 19857534-1 2010 Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been considered as a promising treatment strategy for cocaine overdose and addiction, as CocE is the most efficient native enzyme yet identified for metabolizing the naturally occurring cocaine. Cocaine 50-57 carboxylesterase 2 Homo sapiens 167-171 19857534-1 2010 Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been considered as a promising treatment strategy for cocaine overdose and addiction, as CocE is the most efficient native enzyme yet identified for metabolizing the naturally occurring cocaine. Cocaine 50-57 carboxylesterase 2 Homo sapiens 68-72 19857534-1 2010 Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been considered as a promising treatment strategy for cocaine overdose and addiction, as CocE is the most efficient native enzyme yet identified for metabolizing the naturally occurring cocaine. Cocaine 50-57 carboxylesterase 2 Homo sapiens 167-171 19857534-3 2010 PEGylation, namely by modifying a protein or peptide compound via attachment of polyethylene glycol (PEG) chains, has been proven to overcome such problems and was therefore exploited in this CocE investigation. Polyethylene Glycols 80-99 carboxylesterase 2 Homo sapiens 192-196 19857534-3 2010 PEGylation, namely by modifying a protein or peptide compound via attachment of polyethylene glycol (PEG) chains, has been proven to overcome such problems and was therefore exploited in this CocE investigation. Polyethylene Glycols 0-3 carboxylesterase 2 Homo sapiens 192-196 19857534-4 2010 The PEG-CocE conjugates prepared in this study showed a purity of greater than 93.5%. Polyethylene Glycols 4-7 carboxylesterase 2 Homo sapiens 8-12 19857534-5 2010 Attachment of PEG to CocE apparently inhibited the binding of anti-CocE antibodies to the conjugate, as demonstrated by the enzyme-linked immunosorbent assay (ELISA) assay. Polyethylene Glycols 14-17 carboxylesterase 2 Homo sapiens 21-25 19857534-5 2010 Attachment of PEG to CocE apparently inhibited the binding of anti-CocE antibodies to the conjugate, as demonstrated by the enzyme-linked immunosorbent assay (ELISA) assay. Polyethylene Glycols 14-17 carboxylesterase 2 Homo sapiens 67-71 19857534-7 2010 Furthermore, preliminary in vivo results suggested that, similarly to native CocE, the PEG-CocE conjugates were able to protect animals from cocaine-induced toxic effects. Polyethylene Glycols 87-90 carboxylesterase 2 Homo sapiens 91-95 19857534-7 2010 Furthermore, preliminary in vivo results suggested that, similarly to native CocE, the PEG-CocE conjugates were able to protect animals from cocaine-induced toxic effects. Cocaine 141-148 carboxylesterase 2 Homo sapiens 91-95 20067290-3 2010 By integrating the salicylate group into the carbamate design, we have produced isosorbide-2-benzyl carbamate-5-salicylate, an inhibitor of high potency (150 pM) and selectivity for human BuChE over AChE (666000) and CES2 (23000). Salicylates 19-29 carboxylesterase 2 Homo sapiens 217-221 20067290-3 2010 By integrating the salicylate group into the carbamate design, we have produced isosorbide-2-benzyl carbamate-5-salicylate, an inhibitor of high potency (150 pM) and selectivity for human BuChE over AChE (666000) and CES2 (23000). Carbamates 45-54 carboxylesterase 2 Homo sapiens 217-221 20067290-3 2010 By integrating the salicylate group into the carbamate design, we have produced isosorbide-2-benzyl carbamate-5-salicylate, an inhibitor of high potency (150 pM) and selectivity for human BuChE over AChE (666000) and CES2 (23000). isosorbide-2-benzyl carbamate-5-salicylate 80-122 carboxylesterase 2 Homo sapiens 217-221 19923255-10 2010 Furthermore, the proposed evaluation system was tested for ethyl fexofenadine (ethyl-FXD), which is a superior substrate for hCE1 but a poor one for hCE2. ethyl fexofenadine 59-77 carboxylesterase 2 Homo sapiens 149-153 19923255-10 2010 Furthermore, the proposed evaluation system was tested for ethyl fexofenadine (ethyl-FXD), which is a superior substrate for hCE1 but a poor one for hCE2. ethyl fexofenadine 79-88 carboxylesterase 2 Homo sapiens 149-153 19274604-0 2009 Influence of carboxylesterase 2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Mycophenolic Acid 58-75 carboxylesterase 2 Homo sapiens 13-31 19701081-2 2010 Treatment with a comprehensive program using second-line chemotherapy with ICE (ifosfamide, carboplatin, etoposide) before HDT/ASCT identified a clinical prognostic model, but prognostic biologic markers in relapsed/refractory HL remain unclear. Ifosfamide 80-90 carboxylesterase 2 Homo sapiens 75-78 19701081-2 2010 Treatment with a comprehensive program using second-line chemotherapy with ICE (ifosfamide, carboplatin, etoposide) before HDT/ASCT identified a clinical prognostic model, but prognostic biologic markers in relapsed/refractory HL remain unclear. Carboplatin 92-103 carboxylesterase 2 Homo sapiens 75-78 19701081-2 2010 Treatment with a comprehensive program using second-line chemotherapy with ICE (ifosfamide, carboplatin, etoposide) before HDT/ASCT identified a clinical prognostic model, but prognostic biologic markers in relapsed/refractory HL remain unclear. Etoposide 105-114 carboxylesterase 2 Homo sapiens 75-78 19812521-5 2009 RESULTS: Rate of Tc reduction during the first 20 min of cooling was greater for FAN compared with ICE (0.09 +/- 0.02 degrees C.min vs 0.07 +/- 0.02 degrees C.min, P < 0.05), whereas IV did not differ with the other trials (0.08 +/- 0.01 degrees C.min, P > 0.05). Technetium 17-19 carboxylesterase 2 Homo sapiens 99-102 19753313-7 2009 Cell viability as measured by the MTT assay declined by 30%-50% in HCE-2 cells and by 20%-40% in HCECs after UV-B irradiation. monooxyethylene trimethylolpropane tristearate 34-37 carboxylesterase 2 Homo sapiens 67-72 19642701-0 2009 Fundamental reaction mechanism and free energy profile for (-)-cocaine hydrolysis catalyzed by cocaine esterase. Cocaine 59-70 carboxylesterase 2 Homo sapiens 95-111 19642701-1 2009 The fundamental reaction mechanism of cocaine esterase (CocE)-catalyzed hydrolysis of (-)-cocaine and the corresponding free energy profile have been studied by performing pseudobond first-principles quantum mechanical/molecular mechanical free energy (QM/MM-FE) calculations. Cocaine 86-97 carboxylesterase 2 Homo sapiens 38-54 19642701-1 2009 The fundamental reaction mechanism of cocaine esterase (CocE)-catalyzed hydrolysis of (-)-cocaine and the corresponding free energy profile have been studied by performing pseudobond first-principles quantum mechanical/molecular mechanical free energy (QM/MM-FE) calculations. Cocaine 86-97 carboxylesterase 2 Homo sapiens 56-60 19642701-5 2009 The free energy barrier calculated for the rate-determining step of CocE-catalyzed hydrolysis of (-)-cocaine is 17.9 kcal/mol, which is in good agreement with the experimentally derived activation free energy of 16.2 kcal/mol. Cocaine 97-108 carboxylesterase 2 Homo sapiens 68-72 19695195-1 2009 OBJECTIVE: To evaluate the efficacy and safety of the ICE regimen (iphosphamide + carboplatin + etoposide) used in treating children with hepatoblastoma in the Shanghai Children"s Medical Center. Ifosfamide 67-79 carboxylesterase 2 Homo sapiens 54-57 19249324-7 2009 Some pyrethroids such as bioresmethrin were preferably hydrolyzed by carboxylesterase HCE1, whereas others such as bifenthrin preferably by HCE2. bifenthrin 115-125 carboxylesterase 2 Homo sapiens 140-144 19225040-5 2009 Hydrolysis of imidapril and irinotecan hydrochloride (CPT-11) is catalyzed mainly by CES1 and CES2, respectively. imidapril 14-23 carboxylesterase 2 Homo sapiens 94-98 19225040-5 2009 Hydrolysis of imidapril and irinotecan hydrochloride (CPT-11) is catalyzed mainly by CES1 and CES2, respectively. Irinotecan 28-52 carboxylesterase 2 Homo sapiens 94-98 19225040-5 2009 Hydrolysis of imidapril and irinotecan hydrochloride (CPT-11) is catalyzed mainly by CES1 and CES2, respectively. Irinotecan 54-60 carboxylesterase 2 Homo sapiens 94-98 19761868-5 2010 Here, we report the direct inhibitory effects of several endogenous oxysterols and fatty acids on the CE activity of THP1 monocytes/macrophages and recombinant human CES1 and CES2. Oxysterols 68-78 carboxylesterase 2 Homo sapiens 175-179 19761868-5 2010 Here, we report the direct inhibitory effects of several endogenous oxysterols and fatty acids on the CE activity of THP1 monocytes/macrophages and recombinant human CES1 and CES2. Fatty Acids 83-94 carboxylesterase 2 Homo sapiens 175-179 20302130-3 2010 The products are orthorhombic Ce2 O(CO3)2.H2O with valence III by using homogeneous precipitation method directly. Water 42-45 carboxylesterase 2 Homo sapiens 30-33 19845677-1 2009 BACKGROUND AND PURPOSE: Tecarfarin (ATI-5923) is a novel vitamin K epoxide reductase inhibitor that is metabolized by esterase (mainly human carboxylesterase 2) to a single major metabolite, ATI-5900, in rats, dogs and humans. tecarfarin 24-34 carboxylesterase 2 Homo sapiens 141-159 19845677-1 2009 BACKGROUND AND PURPOSE: Tecarfarin (ATI-5923) is a novel vitamin K epoxide reductase inhibitor that is metabolized by esterase (mainly human carboxylesterase 2) to a single major metabolite, ATI-5900, in rats, dogs and humans. tecarfarin 36-44 carboxylesterase 2 Homo sapiens 141-159 19845677-1 2009 BACKGROUND AND PURPOSE: Tecarfarin (ATI-5923) is a novel vitamin K epoxide reductase inhibitor that is metabolized by esterase (mainly human carboxylesterase 2) to a single major metabolite, ATI-5900, in rats, dogs and humans. 4-Amino-2,2,5,5-tetramethyl-3-imidazoli-ne-1-yloxyl free radical 36-39 carboxylesterase 2 Homo sapiens 141-159 19478136-1 2009 We previously found that a quadruple mutant cocaine hydrolase derived from human butyrylcholinesterase [termed cocaine esterase (CocE)] can suppress or reverse cocaine toxicity and abolish drug-primed reinstatement in rats. Cocaine 44-51 carboxylesterase 2 Homo sapiens 111-127 19478136-1 2009 We previously found that a quadruple mutant cocaine hydrolase derived from human butyrylcholinesterase [termed cocaine esterase (CocE)] can suppress or reverse cocaine toxicity and abolish drug-primed reinstatement in rats. Cocaine 44-51 carboxylesterase 2 Homo sapiens 129-133 19478136-2 2009 Here, we examined whether gene transfer of CocE reduces cocaine actions in brain reward centers. Cocaine 56-63 carboxylesterase 2 Homo sapiens 43-47 19339378-6 2009 In contrast, carboxylesterase1 (CES1) and CES2, which are responsible for the hydrolysis of many drugs, could not hydrolyze flutamide. Flutamide 124-133 carboxylesterase 2 Homo sapiens 42-46 27033652-4 2009 The IBPs, which do not resemble any known antifreezes, have strong recrystallization inhibition activity and have an ability to slow the drainage of brine from sea ice. brine 149-154 carboxylesterase 2 Homo sapiens 164-167 19066926-0 2009 Ice as a water-equivalent solid medium for brachytherapy dosimetric measurements. Water 9-14 carboxylesterase 2 Homo sapiens 0-3 19066926-6 2009 Ice-to-water conversion factors are calculated at distances of 0.2-10 cm from the source, for six high- and low-energy photon-emitting brachytherapy sources and mono-energetic photons between 10 keV to 2.0 MeV. Water 7-12 carboxylesterase 2 Homo sapiens 0-3 19185566-3 2009 In this study, we investigated the role of CES1 and CES2 in converting the antihypertensive prodrug trandolapril to its more active form trandolaprilat, and determined the influence of two newly identified CES1 mutations p.Gly143Glu and p.Asp260fs on trandolapril metabolism. trandolapril 100-112 carboxylesterase 2 Homo sapiens 52-56 18983829-0 2009 Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin. Oseltamivir 121-132 carboxylesterase 2 Homo sapiens 33-37 18987161-1 2009 Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been recognized as a promising treatment strategy for cocaine overdose and addiction, because CocE is the most efficient native enzyme for metabolizing the naturally occurring cocaine yet identified. Cocaine 10-17 carboxylesterase 2 Homo sapiens 50-66 18987161-1 2009 Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been recognized as a promising treatment strategy for cocaine overdose and addiction, because CocE is the most efficient native enzyme for metabolizing the naturally occurring cocaine yet identified. Cocaine 10-17 carboxylesterase 2 Homo sapiens 68-72 18987161-1 2009 Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been recognized as a promising treatment strategy for cocaine overdose and addiction, because CocE is the most efficient native enzyme for metabolizing the naturally occurring cocaine yet identified. Cocaine 10-17 carboxylesterase 2 Homo sapiens 172-176 18987161-1 2009 Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been recognized as a promising treatment strategy for cocaine overdose and addiction, because CocE is the most efficient native enzyme for metabolizing the naturally occurring cocaine yet identified. Cocaine 50-57 carboxylesterase 2 Homo sapiens 68-72 18987161-1 2009 Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been recognized as a promising treatment strategy for cocaine overdose and addiction, because CocE is the most efficient native enzyme for metabolizing the naturally occurring cocaine yet identified. Cocaine 50-57 carboxylesterase 2 Homo sapiens 172-176 18987161-1 2009 Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been recognized as a promising treatment strategy for cocaine overdose and addiction, because CocE is the most efficient native enzyme for metabolizing the naturally occurring cocaine yet identified. Cocaine 50-57 carboxylesterase 2 Homo sapiens 68-72 18987161-1 2009 Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been recognized as a promising treatment strategy for cocaine overdose and addiction, because CocE is the most efficient native enzyme for metabolizing the naturally occurring cocaine yet identified. Cocaine 50-57 carboxylesterase 2 Homo sapiens 172-176 18983829-0 2009 Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin. Aspirin 134-141 carboxylesterase 2 Homo sapiens 33-37 18983829-0 2009 Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin. decamethrin 143-155 carboxylesterase 2 Homo sapiens 33-37 18983829-0 2009 Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin. Permethrin 160-170 carboxylesterase 2 Homo sapiens 33-37 19079454-4 2008 Exemplary results of the simultaneous investigation of mixture formation and combustion obtained at an optical accessible hydrogen ICE are shown. Hydrogen 122-130 carboxylesterase 2 Homo sapiens 131-134 18473752-3 2008 The present study prospectively examined the possible relationship between the toxicity and efficacy of capecitabine and 14 different polymorphisms in CES 2, CDD, TS and DPD. Capecitabine 104-116 carboxylesterase 2 Homo sapiens 151-156 18666762-0 2008 Spectroscopic and theoretical study of endohedral dimetallofullerene having a non-IPR fullerene cage: Ce2@C72. dimetallofullerene 50-68 carboxylesterase 2 Homo sapiens 102-105 18666762-0 2008 Spectroscopic and theoretical study of endohedral dimetallofullerene having a non-IPR fullerene cage: Ce2@C72. Fullerenes 59-68 carboxylesterase 2 Homo sapiens 102-105 18666762-1 2008 The endohedral dimetallofullerene having a non-IPR fullerene cage, Ce2@C72, is spectroscopically and theoretically characterized. dimetallofullerene 15-33 carboxylesterase 2 Homo sapiens 67-70 18666762-1 2008 The endohedral dimetallofullerene having a non-IPR fullerene cage, Ce2@C72, is spectroscopically and theoretically characterized. Fullerenes 24-33 carboxylesterase 2 Homo sapiens 67-70 18372401-3 2008 The presumed role of the human liver- and intestinal-dominant carboxylesterases, hCE1 and hCE2, respectively, in the conversion of prasugrel to R-95913 was determined using expressed and purified enzymes. Prasugrel Hydrochloride 131-140 carboxylesterase 2 Homo sapiens 90-94 18372401-6 2008 Hydrolysis of prasugrel by hCE2 showed a mixture of Hill kinetics at low substrate concentrations and substrate inhibition at high concentrations. Prasugrel Hydrochloride 14-23 carboxylesterase 2 Homo sapiens 27-31 18372401-7 2008 At low concentrations, prasugrel hydrolysis by hCE2 yielded an apparent K(s) of 11.1 microM, an apparent V(max) of 19.0 nmol/min/microg, and an apparent Hill coefficient of 1.42, whereas at high concentrations, an apparent IC(50) of 76.5 microM was obtained. Prasugrel Hydrochloride 23-32 carboxylesterase 2 Homo sapiens 47-51 18573848-5 2008 Chemotherapy consisted of ifosfamide, cisplatin and etoposide (ICE chemotherapy). Etoposide 52-61 carboxylesterase 2 Homo sapiens 63-66 18473752-0 2008 A carboxylesterase 2 gene polymorphism as predictor of capecitabine on response and time to progression. Capecitabine 55-67 carboxylesterase 2 Homo sapiens 2-20 18473752-1 2008 Capecitabine is a drug that requires the consecutive action of three enzymes: carboxylesterase 2 (CES 2), cytidine deaminase (CDD), and thymidine phosphorylase (TP) for transformation into 5-fluorouracil (5FU). Capecitabine 0-12 carboxylesterase 2 Homo sapiens 78-96 18473752-1 2008 Capecitabine is a drug that requires the consecutive action of three enzymes: carboxylesterase 2 (CES 2), cytidine deaminase (CDD), and thymidine phosphorylase (TP) for transformation into 5-fluorouracil (5FU). Capecitabine 0-12 carboxylesterase 2 Homo sapiens 98-103 18771527-0 2008 Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerase I inhibitor, irinotecan (CPT-11), for multiple myeloma. Irinotecan 96-106 carboxylesterase 2 Homo sapiens 18-36 18771527-0 2008 Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerase I inhibitor, irinotecan (CPT-11), for multiple myeloma. Irinotecan 108-114 carboxylesterase 2 Homo sapiens 18-36 18771527-5 2008 Interestingly, high expression of hCE-2 represented the nature of normal plasma cells, suggesting that hCE-2 could efficiently generate SN-38 within the plasma cells. Irinotecan 136-141 carboxylesterase 2 Homo sapiens 34-39 18771527-5 2008 Interestingly, high expression of hCE-2 represented the nature of normal plasma cells, suggesting that hCE-2 could efficiently generate SN-38 within the plasma cells. Irinotecan 136-141 carboxylesterase 2 Homo sapiens 103-108 18771527-6 2008 As expected, higher sensitivity to CPT-11 was observed in hCE-2-overexpressing U266 cells than mock U266 cells. Irinotecan 35-41 carboxylesterase 2 Homo sapiens 58-63 18473752-1 2008 Capecitabine is a drug that requires the consecutive action of three enzymes: carboxylesterase 2 (CES 2), cytidine deaminase (CDD), and thymidine phosphorylase (TP) for transformation into 5-fluorouracil (5FU). Fluorouracil 189-203 carboxylesterase 2 Homo sapiens 78-96 18473752-1 2008 Capecitabine is a drug that requires the consecutive action of three enzymes: carboxylesterase 2 (CES 2), cytidine deaminase (CDD), and thymidine phosphorylase (TP) for transformation into 5-fluorouracil (5FU). Fluorouracil 189-203 carboxylesterase 2 Homo sapiens 98-103 18473752-7 2008 For the first time, an association between a polymorphism in the CES2 gene and the efficacy of capecitabine has been described, providing preliminary evidence of its predictive and prognostic value. Capecitabine 95-107 carboxylesterase 2 Homo sapiens 65-69 18473752-1 2008 Capecitabine is a drug that requires the consecutive action of three enzymes: carboxylesterase 2 (CES 2), cytidine deaminase (CDD), and thymidine phosphorylase (TP) for transformation into 5-fluorouracil (5FU). Fluorouracil 205-208 carboxylesterase 2 Homo sapiens 78-96 18305428-6 2008 In contrast, the CES2 isozyme recognizes a substrate with a large alcohol group and small acyl group, and its substrate specificity may be restricted by the capability of acyl-enzyme conjugate formation due to the presence of conformational interference in the active pocket. Alcohols 66-73 carboxylesterase 2 Homo sapiens 17-21 17483951-1 2008 PURPOSE: Carboxylesterase 2 (CES2) is involved in the activation of the anticancer drug irinotecan to its active metabolite SN-38. Irinotecan 88-98 carboxylesterase 2 Homo sapiens 9-27 17483951-1 2008 PURPOSE: Carboxylesterase 2 (CES2) is involved in the activation of the anticancer drug irinotecan to its active metabolite SN-38. Irinotecan 88-98 carboxylesterase 2 Homo sapiens 29-33 17483951-1 2008 PURPOSE: Carboxylesterase 2 (CES2) is involved in the activation of the anticancer drug irinotecan to its active metabolite SN-38. Irinotecan 124-129 carboxylesterase 2 Homo sapiens 9-27 17483951-1 2008 PURPOSE: Carboxylesterase 2 (CES2) is involved in the activation of the anticancer drug irinotecan to its active metabolite SN-38. Irinotecan 124-129 carboxylesterase 2 Homo sapiens 29-33 17483951-4 2008 CES2 genotypes were tentatively related to irinotecan cytotoxicity and CES2 expression in the NCI-60 panel; to response to treatment and event-free survival in colorectal cancer patients; and to CES2 expression and catalytic activity in subsets of the human liver collection. Irinotecan 43-53 carboxylesterase 2 Homo sapiens 0-4 17889094-4 2007 Parabens are hydrolysed by carboxylesterases to 4-hydroxybenzoic acid. Parabens 0-8 carboxylesterase 2 Homo sapiens 27-44 17889094-4 2007 Parabens are hydrolysed by carboxylesterases to 4-hydroxybenzoic acid. 4-hydroxybenzoic acid 48-69 carboxylesterase 2 Homo sapiens 27-44 17889094-5 2007 The effects of the carboxylesterase inhibitors paraoxon and bis-nitrophenylphosphate provided evidence of the involvement of dermal carboxylesterases in paraben hydrolysis. Paraoxon 47-55 carboxylesterase 2 Homo sapiens 19-35 17889094-5 2007 The effects of the carboxylesterase inhibitors paraoxon and bis-nitrophenylphosphate provided evidence of the involvement of dermal carboxylesterases in paraben hydrolysis. Paraoxon 47-55 carboxylesterase 2 Homo sapiens 132-149 17889094-5 2007 The effects of the carboxylesterase inhibitors paraoxon and bis-nitrophenylphosphate provided evidence of the involvement of dermal carboxylesterases in paraben hydrolysis. bis-nitrophenylphosphate 60-84 carboxylesterase 2 Homo sapiens 19-35 17889094-5 2007 The effects of the carboxylesterase inhibitors paraoxon and bis-nitrophenylphosphate provided evidence of the involvement of dermal carboxylesterases in paraben hydrolysis. bis-nitrophenylphosphate 60-84 carboxylesterase 2 Homo sapiens 132-149 17889094-6 2007 Loperamide, a specific inhibitor of human carboxylesterase-2 inhibited butyl- and benzylparaben hydrolysis in human skin but not methylparaben or ethylparaben. Loperamide 0-10 carboxylesterase 2 Homo sapiens 42-60 17889094-6 2007 Loperamide, a specific inhibitor of human carboxylesterase-2 inhibited butyl- and benzylparaben hydrolysis in human skin but not methylparaben or ethylparaben. benzylparaben 82-95 carboxylesterase 2 Homo sapiens 42-60 17889094-7 2007 These results show that butyl- and benzylparaben are more selective substrates for human carboxylesterase-2 in skin than the other parabens examined. butyl- and benzylparaben 24-48 carboxylesterase 2 Homo sapiens 89-107 17600085-8 2007 In conclusion, dexamethasone comedication in ICE chemotherapy did not change the ifosfamide pharmacokinetics. Dexamethasone 15-28 carboxylesterase 2 Homo sapiens 45-48 17664252-3 2007 Loperamide inhibited procaine hydrolysis by human skin, suggesting involvement of human carboxylesterase hCE2. Loperamide 0-10 carboxylesterase 2 Homo sapiens 105-109 17664252-3 2007 Loperamide inhibited procaine hydrolysis by human skin, suggesting involvement of human carboxylesterase hCE2. Procaine 21-29 carboxylesterase 2 Homo sapiens 105-109 17640957-1 2007 Human carboxylesterase 2 (hCE-2) is a member of the serine esterase superfamily and is responsible for hydrolysis of a wide variety of xenobiotic and endogenous esters. Esters 161-167 carboxylesterase 2 Homo sapiens 6-24 17640957-1 2007 Human carboxylesterase 2 (hCE-2) is a member of the serine esterase superfamily and is responsible for hydrolysis of a wide variety of xenobiotic and endogenous esters. Esters 161-167 carboxylesterase 2 Homo sapiens 26-31 17651701-9 2007 Lower correlations with larger alcohol leaving group parabens are consistent with more hCE2 involvement. Alcohols 31-38 carboxylesterase 2 Homo sapiens 87-91 17640957-2 2007 hCE-2 also activates an anticancer drug, irinotecan (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin, CPT-11), into its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38). Irinotecan 41-51 carboxylesterase 2 Homo sapiens 0-5 17640957-2 2007 hCE-2 also activates an anticancer drug, irinotecan (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin, CPT-11), into its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38). Irinotecan 53-119 carboxylesterase 2 Homo sapiens 0-5 17640957-2 2007 hCE-2 also activates an anticancer drug, irinotecan (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin, CPT-11), into its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38). Irinotecan 121-127 carboxylesterase 2 Homo sapiens 0-5 17640957-2 2007 hCE-2 also activates an anticancer drug, irinotecan (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin, CPT-11), into its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38). Irinotecan 158-188 carboxylesterase 2 Homo sapiens 0-5 17640957-2 2007 hCE-2 also activates an anticancer drug, irinotecan (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin, CPT-11), into its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38). Irinotecan 190-195 carboxylesterase 2 Homo sapiens 0-5 17651701-9 2007 Lower correlations with larger alcohol leaving group parabens are consistent with more hCE2 involvement. Parabens 53-61 carboxylesterase 2 Homo sapiens 87-91 17131989-1 2006 A series of proteins with cocaine esterase ability have been shown to hydrolyze acetylcholine with similar rate enhancements. Acetylcholine 80-93 carboxylesterase 2 Homo sapiens 26-42 17537833-0 2007 Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2. Clopidogrel 52-63 carboxylesterase 2 Homo sapiens 126-143 17537833-0 2007 Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2. Clopidogrel 52-63 carboxylesterase 2 Homo sapiens 153-157 17537833-0 2007 Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2. Irinotecan 65-75 carboxylesterase 2 Homo sapiens 126-143 17537833-0 2007 Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2. Irinotecan 65-75 carboxylesterase 2 Homo sapiens 153-157 17537833-0 2007 Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2. Oseltamivir 81-92 carboxylesterase 2 Homo sapiens 126-143 17537833-0 2007 Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2. Oseltamivir 81-92 carboxylesterase 2 Homo sapiens 153-157 17537833-7 2007 In addition, pretreatment with IL-6 altered the cellular responsiveness in an opposite manner of overexpression of HCE1 and HCE2 toward various ester therapeutic agents (e.g., clopidogrel). Esters 144-149 carboxylesterase 2 Homo sapiens 124-128 17537833-7 2007 In addition, pretreatment with IL-6 altered the cellular responsiveness in an opposite manner of overexpression of HCE1 and HCE2 toward various ester therapeutic agents (e.g., clopidogrel). Clopidogrel 176-187 carboxylesterase 2 Homo sapiens 124-128 17643587-0 2007 Immediate and intermediate results of intracoronary stand-alone bolus administration of eptifibatide during coronary intervention (ICE) study. Eptifibatide 88-100 carboxylesterase 2 Homo sapiens 131-134 17409690-8 2007 hCE2 preferentially hydrolyzes substrates with a small acyl moiety such as CPT-11, due to conformational steric hindrance in its active site. Irinotecan 75-81 carboxylesterase 2 Homo sapiens 0-4 17329851-5 2007 hCE-2 is thus an abundant carboxylesterase in HaCaT keratinocytes which may be responsible for stereoselective hydrolysis of ketoprofen ethyl ester. Ethyl 2-(3-benzoylphenyl)propanoate 125-147 carboxylesterase 2 Homo sapiens 0-5 17936933-10 2007 The hydrolytic activity specifically attributable to hCE1 and hCE2 in individual HLMs was measured using bioresmethrin (a pyrethroid insecticide hydrolyzed specifically by hCE1, but not by hCE2) and procaine (an analgesic drug hydrolyzed by hCE2, but not by hCE1). bioresmethrin 105-118 carboxylesterase 2 Homo sapiens 62-66 17936933-10 2007 The hydrolytic activity specifically attributable to hCE1 and hCE2 in individual HLMs was measured using bioresmethrin (a pyrethroid insecticide hydrolyzed specifically by hCE1, but not by hCE2) and procaine (an analgesic drug hydrolyzed by hCE2, but not by hCE1). Pyrethrins 122-132 carboxylesterase 2 Homo sapiens 62-66 17003103-0 2007 Photochemotherapeutic agent 8-methoxypsoralen induces cytochrome P450 3A4 and carboxylesterase HCE2: evidence on an involvement of the pregnane X receptor. Methoxsalen 28-45 carboxylesterase 2 Homo sapiens 95-99 17003103-3 2007 In this study, we report that 8-MOP is a potent inducer of cytochrome P450 3A4 (CYP3A4) and carboxylesterase 2 (HCE2), two major human enzymes that catalyze oxidative and hydrolytic reactions, respectively. Methoxsalen 30-35 carboxylesterase 2 Homo sapiens 92-110 17003103-3 2007 In this study, we report that 8-MOP is a potent inducer of cytochrome P450 3A4 (CYP3A4) and carboxylesterase 2 (HCE2), two major human enzymes that catalyze oxidative and hydrolytic reactions, respectively. Methoxsalen 30-35 carboxylesterase 2 Homo sapiens 112-116 17003103-4 2007 In human primary hepatocytes, 8-MOP markedly induced the expression of CYP3A4 (approximately sixfold) and HCE2 (approximately threefold) and the induction occurred in a concentration-dependent manner (0-50 microM). Methoxsalen 30-35 carboxylesterase 2 Homo sapiens 106-110 17003103-6 2007 In a reporter assay, 8-MOP stimulated both CYP3A4 and HCE2 promoters, and the stimulation was enhanced by cotransfection of PXR. Methoxsalen 21-26 carboxylesterase 2 Homo sapiens 54-58 16772877-2 2006 However, a combination of ICE (ifosfamide, carboplatin, and etoposide) and VDCy (vincristine, doxorubicin, and cyclophosphamide) was recently reported to be effective for metastatic MRTK. Ifosfamide 31-41 carboxylesterase 2 Homo sapiens 26-29 16943252-8 2006 Consistent with the tissue distribution of two carboxylesterases human carboxylesterase (HCE) 1 and HCE2, recombinant HCE1 hydrolyzed clopidogrel, whereas recombinant HCE2 hydrolyzed aspirin. Clopidogrel 134-145 carboxylesterase 2 Homo sapiens 100-104 16963839-3 2006 We examined whether p53 activated by the DNA-damaging drug 5-fluorouracil (5-FU) also induces CES-2 expression. Fluorouracil 59-73 carboxylesterase 2 Homo sapiens 94-99 16963839-3 2006 We examined whether p53 activated by the DNA-damaging drug 5-fluorouracil (5-FU) also induces CES-2 expression. Fluorouracil 75-79 carboxylesterase 2 Homo sapiens 94-99 16963839-4 2006 Our experiments showed that 5-FU induced CES-2 expression in two colon carcinoma cell lines that express wild-type p53 (HCT116 p53(+/+) and RKO) but not in five lines that are p53-null (HCT116 p53(-/- )) or express mutated p53 (HT29, KM12C, KM12SM, and KM12L4A). Fluorouracil 28-32 carboxylesterase 2 Homo sapiens 41-46 16963839-7 2006 Chromatin immunoprecipitation assay confirmed that p53 bound the CES-2 fragment containing the p53-binding element after 5-FU treatment, whereas p21 binding to p53 was present with or without chemotherapy. Fluorouracil 121-125 carboxylesterase 2 Homo sapiens 65-70 16837570-4 2006 Interestingly, propranolol derivatives, good substrates for hCE-2, were easily hydrolyzed by substitution of the methyl group on the 2-position of the acyl moiety, but were barely hydrolyzed when the methyl group was substituted on the 3-position. Propranolol 15-26 carboxylesterase 2 Homo sapiens 60-65 16837570-7 2006 The hydrolytic activity of hCE-2 increased with increasing alcohol chain length in benzoic acid derivative substrates, whereas hCE-1 preferentially catalyzed the hydrolysis of substrates with short alcohol chains. Alcohols 59-66 carboxylesterase 2 Homo sapiens 27-32 16837570-7 2006 The hydrolytic activity of hCE-2 increased with increasing alcohol chain length in benzoic acid derivative substrates, whereas hCE-1 preferentially catalyzed the hydrolysis of substrates with short alcohol chains. Benzoic Acid 83-95 carboxylesterase 2 Homo sapiens 27-32 16837570-7 2006 The hydrolytic activity of hCE-2 increased with increasing alcohol chain length in benzoic acid derivative substrates, whereas hCE-1 preferentially catalyzed the hydrolysis of substrates with short alcohol chains. Alcohols 198-205 carboxylesterase 2 Homo sapiens 27-32 16837570-8 2006 Kinetic data showed that the determining factor for the rate of hydrolysis of p-aminobenzoic acid esters was V(max) for hCE-1 and K(m) for hCE-2. p-aminobenzoic acid esters 78-104 carboxylesterase 2 Homo sapiens 139-144 16837570-9 2006 Furthermore, the addition of hydrophobic alcohols to the reaction mixture with p-aminobenzoic acid propyl ester induced high and low levels of transesterification by hCE-1 and hCE-2, respectively. Alcohols 41-49 carboxylesterase 2 Homo sapiens 176-181 16837570-9 2006 Furthermore, the addition of hydrophobic alcohols to the reaction mixture with p-aminobenzoic acid propyl ester induced high and low levels of transesterification by hCE-1 and hCE-2, respectively. propyl 4-aminobenzoate 79-111 carboxylesterase 2 Homo sapiens 176-181 17287894-5 2006 Reverse transcription-polymerase chain reaction analysis revealed that exposure to 5-FU downregulated both MDR1 and bcl-2 mRNA and simultaneously upregulated CE2 mRNA expression, suggesting enhancement of subsequent CPT-11 cytotoxicity. Fluorouracil 83-87 carboxylesterase 2 Homo sapiens 158-161 16943252-8 2006 Consistent with the tissue distribution of two carboxylesterases human carboxylesterase (HCE) 1 and HCE2, recombinant HCE1 hydrolyzed clopidogrel, whereas recombinant HCE2 hydrolyzed aspirin. Aspirin 183-190 carboxylesterase 2 Homo sapiens 100-104 16943252-8 2006 Consistent with the tissue distribution of two carboxylesterases human carboxylesterase (HCE) 1 and HCE2, recombinant HCE1 hydrolyzed clopidogrel, whereas recombinant HCE2 hydrolyzed aspirin. Aspirin 183-190 carboxylesterase 2 Homo sapiens 167-171 16943252-9 2006 In addition, hydrolysis of clopidogrel among liver samples was correlated well with the level of HCE1, and hydrolysis of aspirin with HCE2. Aspirin 121-128 carboxylesterase 2 Homo sapiens 134-138 17125253-6 2006 Pentyl 4-(N-doxazolidinylcarbonyloxymethyl)phenylcarbamate, the lead compound for further investigation, appears to be activated in Hep G2 cells that express both CES1 and CES2. pentyl 4-(N-doxazolidinylcarbonyloxymethyl)phenylcarbamate 0-58 carboxylesterase 2 Homo sapiens 172-176 16928109-2 2006 The cerium carbonyls CeCO and Ce2CO are produced spontaneously on annealing and they are photochemically rearranged to the CCeO and c-Ce2(mu-C)(mu-O) isomers, where Ce and Ce2 are inserted into the CO triple bond. ce2co 30-35 carboxylesterase 2 Homo sapiens 134-137 16928109-2 2006 The cerium carbonyls CeCO and Ce2CO are produced spontaneously on annealing and they are photochemically rearranged to the CCeO and c-Ce2(mu-C)(mu-O) isomers, where Ce and Ce2 are inserted into the CO triple bond. cceo 123-127 carboxylesterase 2 Homo sapiens 30-33 16858120-5 2006 In contrast, hCE-2 recognizes a substrate with a large alcohol group and small acyl group, and its substrate specificity may be restricted by a capability of acyl-hCE-2 conjugate formation due to the presence of conformational interference in the active pocket. Alcohols 55-62 carboxylesterase 2 Homo sapiens 13-18 16858120-5 2006 In contrast, hCE-2 recognizes a substrate with a large alcohol group and small acyl group, and its substrate specificity may be restricted by a capability of acyl-hCE-2 conjugate formation due to the presence of conformational interference in the active pocket. Alcohols 55-62 carboxylesterase 2 Homo sapiens 163-168 16858120-11 2006 The expression pattern of CES in Caco-2 cell monolayer, a useful in vitro model for rapid screening of human intestinal drug absorption, is completely different from that in human small intestine but very similar to human liver that expresses a much higher level of hCE-1 and lower level of hCE-2. Cerium 26-29 carboxylesterase 2 Homo sapiens 291-296 16508919-5 2006 Many enzymes are involved in controlling the disposition of irinotecan, including the cellular target (TOP1), metabolism enzymes (CES2, UGT1A1, CYP3A4, CYP3A5), and cellular transporters of the anti-cancer agent (ABCB1, ABCC1, ABCC2, ABCC3, ABCC5, ABCG2). Irinotecan 60-70 carboxylesterase 2 Homo sapiens 130-134 16702184-1 2006 The age-adjusted International Prognostic Index assessed before salvage therapy with ICE (ifosfamide, carboplatin, etoposide) predicts outcome in patients with relapsed or primary refractory diffuse large B-cell lymphoma (DLBCL). Ifosfamide 90-100 carboxylesterase 2 Homo sapiens 85-88 16702184-1 2006 The age-adjusted International Prognostic Index assessed before salvage therapy with ICE (ifosfamide, carboplatin, etoposide) predicts outcome in patients with relapsed or primary refractory diffuse large B-cell lymphoma (DLBCL). Carboplatin 102-113 carboxylesterase 2 Homo sapiens 85-88 16702184-1 2006 The age-adjusted International Prognostic Index assessed before salvage therapy with ICE (ifosfamide, carboplatin, etoposide) predicts outcome in patients with relapsed or primary refractory diffuse large B-cell lymphoma (DLBCL). Etoposide 115-124 carboxylesterase 2 Homo sapiens 85-88 16772877-2 2006 However, a combination of ICE (ifosfamide, carboplatin, and etoposide) and VDCy (vincristine, doxorubicin, and cyclophosphamide) was recently reported to be effective for metastatic MRTK. Carboplatin 43-54 carboxylesterase 2 Homo sapiens 26-29 16234294-0 2006 Bevacizumab plus high-dose ifosfamide, etoposide and carboplatin (HD-ICE) as third-line salvage chemotherapy induced an unexpected dramatic response in highly platinum refractory germ-cell cancer. Ifosfamide 27-37 carboxylesterase 2 Homo sapiens 69-72 16702735-9 2006 The nafamostat hydrolysis in 18 human liver microsomes correlated with aspirin hydrolytic activity specific for carboxylesterase 2 (r=0.815, p<0.01) but not with imidapril hydrolysis catalyzed by carboxylesterase 1 (r=0.156, p=0.54). Aspirin 71-78 carboxylesterase 2 Homo sapiens 112-130 16702735-10 2006 These results suggest that human arylesterases and carboxylesterase 2 may be predominantly responsible for the metabolism of nafamostat in the blood and liver, respectively. nafamostat 125-135 carboxylesterase 2 Homo sapiens 51-69 16769452-5 2006 Use of Ice (smoked methamphetamine) has increased significantly. Methamphetamine 19-34 carboxylesterase 2 Homo sapiens 7-10 16234294-0 2006 Bevacizumab plus high-dose ifosfamide, etoposide and carboplatin (HD-ICE) as third-line salvage chemotherapy induced an unexpected dramatic response in highly platinum refractory germ-cell cancer. Carboplatin 53-64 carboxylesterase 2 Homo sapiens 69-72 16359636-3 2006 Both hCE-1 and hCE-2 hydrolyzed type I and II pyrethroids with strong stereoselectivity. Pyrethrins 46-57 carboxylesterase 2 Homo sapiens 15-20 16271446-3 2006 Irinotecan is subject to extensive metabolism by various polymorphic enzymes, including CES2 to form SN-38, members of the UGT1A subfamily, and CYP3A4 and CYP3A5, which form several pharmacologically inactive oxidation products. Irinotecan 0-10 carboxylesterase 2 Homo sapiens 88-92 16271446-3 2006 Irinotecan is subject to extensive metabolism by various polymorphic enzymes, including CES2 to form SN-38, members of the UGT1A subfamily, and CYP3A4 and CYP3A5, which form several pharmacologically inactive oxidation products. Irinotecan 101-106 carboxylesterase 2 Homo sapiens 88-92 16387282-5 2006 hCE-1 and hCE-2 hydrolyzed trans-permethrin 8- and 28-fold more efficiently than cis-permethrin (when k(cat)/K(m) values were compared), respectively. Permethrin 81-95 carboxylesterase 2 Homo sapiens 10-15 16387282-10 2006 We also determined that the CE inhibitor 2-chloro-3,4-dimethoxybenzil blocked hCE-2-catalyzed trans-permethrin hydrolysis 36 times more potently than hCE-1. 2-chloro-3,4-dimethoxybenzil 41-69 carboxylesterase 2 Homo sapiens 78-83 16387282-10 2006 We also determined that the CE inhibitor 2-chloro-3,4-dimethoxybenzil blocked hCE-2-catalyzed trans-permethrin hydrolysis 36 times more potently than hCE-1. Permethrin 94-110 carboxylesterase 2 Homo sapiens 78-83 16387282-12 2006 While there are likely other esterases in human liver that hydrolyze pyrethroids, the results of this study clearly demonstrate that hCE-1 and hCE-2 are human pyrethroid-hydrolyzing CEs. Pyrethrins 69-80 carboxylesterase 2 Homo sapiens 143-148 16387282-5 2006 hCE-1 and hCE-2 hydrolyzed trans-permethrin 8- and 28-fold more efficiently than cis-permethrin (when k(cat)/K(m) values were compared), respectively. Permethrin 27-43 carboxylesterase 2 Homo sapiens 10-15 16359636-5 2006 Kinetic values of hCE-1 and hCE-2 were determined using cypermethrin and 11 stereoisomers of the pyrethroid-like, fluorescent surrogates. cypermethrin 56-68 carboxylesterase 2 Homo sapiens 28-33 16203781-1 2005 PURPOSE: Irinotecan (CPT11) is a prodrug activated in humans mainly by carboxylesterase 2 (CES2) generating the SN38 metabolite responsible for the drug efficacy and toxicity. Irinotecan 9-19 carboxylesterase 2 Homo sapiens 71-89 16409617-0 2005 High dose chemotherapy including paclitaxel (T-ICE) combined with peripheral blood stem cell transplantation for male germ cell tumor. Paclitaxel 33-43 carboxylesterase 2 Homo sapiens 47-50 16409617-2 2005 AIM: To evaluate the feasibility and usefulness of high dose chemotherapy including paclitaxel (T-ICE) combined with peripheral blood stem cell transplantation (PBSCT) for male germ cell tumor. Paclitaxel 84-94 carboxylesterase 2 Homo sapiens 98-101 16203781-1 2005 PURPOSE: Irinotecan (CPT11) is a prodrug activated in humans mainly by carboxylesterase 2 (CES2) generating the SN38 metabolite responsible for the drug efficacy and toxicity. Irinotecan 9-19 carboxylesterase 2 Homo sapiens 91-95 16203781-1 2005 PURPOSE: Irinotecan (CPT11) is a prodrug activated in humans mainly by carboxylesterase 2 (CES2) generating the SN38 metabolite responsible for the drug efficacy and toxicity. Irinotecan 21-26 carboxylesterase 2 Homo sapiens 71-89 16203781-1 2005 PURPOSE: Irinotecan (CPT11) is a prodrug activated in humans mainly by carboxylesterase 2 (CES2) generating the SN38 metabolite responsible for the drug efficacy and toxicity. Irinotecan 21-26 carboxylesterase 2 Homo sapiens 91-95 16008466-0 2005 A potential model for the study of ices and amorphous water: TIP4P/Ice. Water 54-59 carboxylesterase 2 Homo sapiens 61-70 16190251-8 2005 The mixture obtained (71% H2: 23% CH4) could be used as a hydrogen source to obtain pure hydrogen or hydrogen-natural gas mixtures to fuel a captive fleet of public urban vehicles powered by fuel cells or dedicated ICE, respectively. Methane 34-37 carboxylesterase 2 Homo sapiens 215-218 16190251-8 2005 The mixture obtained (71% H2: 23% CH4) could be used as a hydrogen source to obtain pure hydrogen or hydrogen-natural gas mixtures to fuel a captive fleet of public urban vehicles powered by fuel cells or dedicated ICE, respectively. Hydrogen 58-66 carboxylesterase 2 Homo sapiens 215-218 16026809-4 2005 The C-terminal residues of Ce2, Ce4 and Ce5 were found to be amidated. ce5 40-43 carboxylesterase 2 Homo sapiens 27-30 15687373-0 2005 Hydrolysis of capecitabine to 5"-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide. Capecitabine 14-26 carboxylesterase 2 Homo sapiens 65-82 15687373-0 2005 Hydrolysis of capecitabine to 5"-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide. 5'-deoxy-5-fluorocytidine 30-55 carboxylesterase 2 Homo sapiens 65-82 15687373-2 2005 A three-step in vivo-targeted activation process requiring carboxylesterases, cytidine deaminase, and thymidine phosphorylase converts capecitabine to 5-fluorouracil. Capecitabine 135-147 carboxylesterase 2 Homo sapiens 59-76 15687373-2 2005 A three-step in vivo-targeted activation process requiring carboxylesterases, cytidine deaminase, and thymidine phosphorylase converts capecitabine to 5-fluorouracil. Fluorouracil 151-165 carboxylesterase 2 Homo sapiens 59-76 15687373-3 2005 Carboxylesterases hydrolyze capecitabine"s carbamate side chain to form 5"-deoxy-5-fluorocytidine (5"-DFCR). Capecitabine 28-40 carboxylesterase 2 Homo sapiens 0-17 15687373-3 2005 Carboxylesterases hydrolyze capecitabine"s carbamate side chain to form 5"-deoxy-5-fluorocytidine (5"-DFCR). Carbamates 43-52 carboxylesterase 2 Homo sapiens 0-17 15687373-3 2005 Carboxylesterases hydrolyze capecitabine"s carbamate side chain to form 5"-deoxy-5-fluorocytidine (5"-DFCR). 5'-deoxy-5-fluorocytidine 72-97 carboxylesterase 2 Homo sapiens 0-17 15687373-3 2005 Carboxylesterases hydrolyze capecitabine"s carbamate side chain to form 5"-deoxy-5-fluorocytidine (5"-DFCR). 5'-deoxy-5-fluorocytidine 99-106 carboxylesterase 2 Homo sapiens 0-17 15687373-4 2005 This study examines the steady-state kinetics of recombinant human carboxylesterase isozymes carboxylesterase (CES) 1A1, CES2, and CES3 for hydrolysis of capecitabine with a liquid chromatography/mass spectroscopy assay. Capecitabine 154-166 carboxylesterase 2 Homo sapiens 121-125 15687373-5 2005 Additionally, a spectrophotometric screening assay was utilized to identify drugs that may inhibit carboxylesterase activation of capecitabine. Capecitabine 130-142 carboxylesterase 2 Homo sapiens 99-115 15687373-6 2005 CES1A1 and CES2 hydrolyze capecitabine to a similar extent, with catalytic efficiencies of 14.7 and 12.9 min(-1) mM(-1), respectively. Capecitabine 26-38 carboxylesterase 2 Homo sapiens 11-15 15687373-10 2005 Loperamide is a strong inhibitor of CES2, with a K(i) of 1.5 muM, but it only weakly inhibits CES1A1 (IC(50) = 0.44 mM). Loperamide 0-10 carboxylesterase 2 Homo sapiens 36-40 15687373-11 2005 Inhibition of CES2 in the gastrointestinal tract by loperamide may reduce local formation of 5"-DFCR. Loperamide 52-62 carboxylesterase 2 Homo sapiens 14-18 15687373-11 2005 Inhibition of CES2 in the gastrointestinal tract by loperamide may reduce local formation of 5"-DFCR. 5'-deoxy-5-fluorocytidine 93-100 carboxylesterase 2 Homo sapiens 14-18 15687373-12 2005 Both CES1A1 and CES2 are responsible for the activation of capecitabine, whereas CES3 plays little role in 5"-DFCR formation. Capecitabine 59-71 carboxylesterase 2 Homo sapiens 16-20 16011259-7 2005 CONCLUSION: Human carboxylesterase-2 is the main hydrolytic enzyme of prodrugs in percutaneous absorption, and shows metabolic stereoselectivity to prodrugs with chiral esters. Esters 169-175 carboxylesterase 2 Homo sapiens 18-36 15727486-10 2005 The enzymes responsible for the activation, metabolism and mechanism of action of irinotecan, namely carboxylesterase 2, cytochrome P450 (CYP) 3A4, uridine diphosphate glucuronosyltransferase isoform 1A1 (UGT1A1), and topoisomerase-I, also exhibit variable interindividual activity. Irinotecan 82-92 carboxylesterase 2 Homo sapiens 101-119 15475733-4 2004 Microsome samples prepared from liver tissues of 78 normal individuals were used to determine the rate of hydrolysis of irinotecan and procaine (an anaesthetic hydrolysed by CES2 but not CES1). Procaine 135-143 carboxylesterase 2 Homo sapiens 174-178 15287915-0 2004 ICE (ifosfamide, carboplatin, etoposide) as second-line chemotherapy in relapsed or primary progressive aggressive lymphoma--the Nordic Lymphoma Group experience. Ifosfamide 5-15 carboxylesterase 2 Homo sapiens 0-3 15287915-0 2004 ICE (ifosfamide, carboplatin, etoposide) as second-line chemotherapy in relapsed or primary progressive aggressive lymphoma--the Nordic Lymphoma Group experience. Carboplatin 17-28 carboxylesterase 2 Homo sapiens 0-3 15287915-0 2004 ICE (ifosfamide, carboplatin, etoposide) as second-line chemotherapy in relapsed or primary progressive aggressive lymphoma--the Nordic Lymphoma Group experience. Etoposide 30-39 carboxylesterase 2 Homo sapiens 0-3 15287915-1 2004 OBJECTIVE: To evaluate ICE (ifosfamide, carboplatin, etoposide) as second-line chemotherapy in relapsed or primary progressive aggressive lymphoma, in terms of objective response rate (ORR) and peripheral blood stem cell (PBSC) harvest mobilization rate. Ifosfamide 28-38 carboxylesterase 2 Homo sapiens 23-26 15287915-1 2004 OBJECTIVE: To evaluate ICE (ifosfamide, carboplatin, etoposide) as second-line chemotherapy in relapsed or primary progressive aggressive lymphoma, in terms of objective response rate (ORR) and peripheral blood stem cell (PBSC) harvest mobilization rate. Carboplatin 40-51 carboxylesterase 2 Homo sapiens 23-26 15287915-1 2004 OBJECTIVE: To evaluate ICE (ifosfamide, carboplatin, etoposide) as second-line chemotherapy in relapsed or primary progressive aggressive lymphoma, in terms of objective response rate (ORR) and peripheral blood stem cell (PBSC) harvest mobilization rate. Etoposide 53-62 carboxylesterase 2 Homo sapiens 23-26 15338266-0 2004 Links between the structure of an Antarctic shallow-water community and ice-scour frequency. Water 52-57 carboxylesterase 2 Homo sapiens 72-75 15592324-0 2004 Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38. Irinotecan 86-96 carboxylesterase 2 Homo sapiens 26-44 15592324-0 2004 Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38. Irinotecan 102-107 carboxylesterase 2 Homo sapiens 26-44 15592324-1 2004 PURPOSE: Irinotecan, a drug widely used in the treatment of advanced colorectal cancers, is a prodrug requiring activation to 7-ethyl-10-hydroxycamptothecin (SN-38) by carboxylesterase 2 (hCE2). Irinotecan 9-19 carboxylesterase 2 Homo sapiens 168-186 15592324-1 2004 PURPOSE: Irinotecan, a drug widely used in the treatment of advanced colorectal cancers, is a prodrug requiring activation to 7-ethyl-10-hydroxycamptothecin (SN-38) by carboxylesterase 2 (hCE2). Irinotecan 9-19 carboxylesterase 2 Homo sapiens 188-192 15592324-1 2004 PURPOSE: Irinotecan, a drug widely used in the treatment of advanced colorectal cancers, is a prodrug requiring activation to 7-ethyl-10-hydroxycamptothecin (SN-38) by carboxylesterase 2 (hCE2). Irinotecan 126-156 carboxylesterase 2 Homo sapiens 168-186 15592324-1 2004 PURPOSE: Irinotecan, a drug widely used in the treatment of advanced colorectal cancers, is a prodrug requiring activation to 7-ethyl-10-hydroxycamptothecin (SN-38) by carboxylesterase 2 (hCE2). Irinotecan 126-156 carboxylesterase 2 Homo sapiens 188-192 15592324-1 2004 PURPOSE: Irinotecan, a drug widely used in the treatment of advanced colorectal cancers, is a prodrug requiring activation to 7-ethyl-10-hydroxycamptothecin (SN-38) by carboxylesterase 2 (hCE2). Irinotecan 158-163 carboxylesterase 2 Homo sapiens 168-186 15592324-1 2004 PURPOSE: Irinotecan, a drug widely used in the treatment of advanced colorectal cancers, is a prodrug requiring activation to 7-ethyl-10-hydroxycamptothecin (SN-38) by carboxylesterase 2 (hCE2). Irinotecan 158-163 carboxylesterase 2 Homo sapiens 188-192 15592324-5 2004 The functionality of the variations identified was studied in 60 human liver samples by measuring hCE2 gene expression by real-time reverse transcriptase-polymerase chain reaction of messenger ribonucleic acid extracts and carboxylesterase activity by use of irinotecan as a substrate. messenger 183-192 carboxylesterase 2 Homo sapiens 98-102 15592324-10 2004 CONCLUSION: The hCE2 gene presents several polymorphisms, none of which seems to be involved in significant variations in protein activity and, therefore, in irinotecan activation. Irinotecan 158-168 carboxylesterase 2 Homo sapiens 16-20 15528798-0 2004 Dicerium orthosilicate selenide and dicerium orthosilicate telluride, Ce2(SiO4)Q (Q = Se or Te). sio4 74-78 carboxylesterase 2 Homo sapiens 70-73 15345817-0 2004 A new chromate of tetravalent cerium: Ce2(CrO4)4.2H2O. Cerium 30-36 carboxylesterase 2 Homo sapiens 38-41 15345817-1 2004 Dicerium(IV) tetrachromate(VI) dihydrate, Ce2(IV)(CrO4)4.2H2O, has been prepared from an acidic aqueous solution at room temperature. dicerium(iv) tetrachromate 0-26 carboxylesterase 2 Homo sapiens 42-45 15345817-1 2004 Dicerium(IV) tetrachromate(VI) dihydrate, Ce2(IV)(CrO4)4.2H2O, has been prepared from an acidic aqueous solution at room temperature. dihydrate 31-40 carboxylesterase 2 Homo sapiens 42-45 15345817-1 2004 Dicerium(IV) tetrachromate(VI) dihydrate, Ce2(IV)(CrO4)4.2H2O, has been prepared from an acidic aqueous solution at room temperature. (cro4)4.2h2o 49-61 carboxylesterase 2 Homo sapiens 42-45 15209502-10 2004 Furthermore, the crystal structure of the bacterial cocaine esterase (cocE) also showed that the cocE employs a tyrosine hydroxyl in the oxyanion hole. tyrosine hydroxyl 112-129 carboxylesterase 2 Homo sapiens 52-68 15082749-0 2004 Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1. Methylphenidate 0-15 carboxylesterase 2 Homo sapiens 57-73 15209502-10 2004 Furthermore, the crystal structure of the bacterial cocaine esterase (cocE) also showed that the cocE employs a tyrosine hydroxyl in the oxyanion hole. tyrosine hydroxyl 112-129 carboxylesterase 2 Homo sapiens 70-74 15209502-10 2004 Furthermore, the crystal structure of the bacterial cocaine esterase (cocE) also showed that the cocE employs a tyrosine hydroxyl in the oxyanion hole. tyrosine hydroxyl 112-129 carboxylesterase 2 Homo sapiens 97-101 15100172-10 2004 CES2 has the highest catalytic activity of 0.012 min(-1) microM(-1) among the three carboxylesterases studied for hydrolysis of CPT-11. Irinotecan hydrochloride 128-134 carboxylesterase 2 Homo sapiens 0-4 15137762-0 2004 Ultrastructure in frozen/etched saline solutions: on the internal cleansing of ice. Sodium Chloride 32-38 carboxylesterase 2 Homo sapiens 79-82 15137762-1 2004 Seawater, with its 3.5% salt content, freezes into hexagonal ice (Ih) that encloses concentrated brine within its matrix. Salts 24-28 carboxylesterase 2 Homo sapiens 61-64 15137762-1 2004 Seawater, with its 3.5% salt content, freezes into hexagonal ice (Ih) that encloses concentrated brine within its matrix. brine 97-102 carboxylesterase 2 Homo sapiens 61-64 15137762-9 2004 Alternatively, channels (perhaps routed around submicroscopic crystallites of cubic ice (Ic) embedded in the amorphous ice at -105 degrees C) can guide the migration of salt to the periphery of ice patches. Salts 169-173 carboxylesterase 2 Homo sapiens 84-87 15137762-9 2004 Alternatively, channels (perhaps routed around submicroscopic crystallites of cubic ice (Ic) embedded in the amorphous ice at -105 degrees C) can guide the migration of salt to the periphery of ice patches. Salts 169-173 carboxylesterase 2 Homo sapiens 89-91 15137762-9 2004 Alternatively, channels (perhaps routed around submicroscopic crystallites of cubic ice (Ic) embedded in the amorphous ice at -105 degrees C) can guide the migration of salt to the periphery of ice patches. Salts 169-173 carboxylesterase 2 Homo sapiens 119-122 15137762-9 2004 Alternatively, channels (perhaps routed around submicroscopic crystallites of cubic ice (Ic) embedded in the amorphous ice at -105 degrees C) can guide the migration of salt to the periphery of ice patches. Salts 169-173 carboxylesterase 2 Homo sapiens 119-122 15100172-0 2004 Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. Irinotecan 14-24 carboxylesterase 2 Homo sapiens 210-227 15100172-0 2004 Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. Irinotecan 14-24 carboxylesterase 2 Homo sapiens 236-240 15100172-0 2004 Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. RPR 121056 56-133 carboxylesterase 2 Homo sapiens 210-227 15100172-1 2004 Carboxylesterases metabolize ester, thioester, carbamate, and amide compounds to more soluble acid, alcohol, and amine products. Carbamates 47-56 carboxylesterase 2 Homo sapiens 0-17 15100172-1 2004 Carboxylesterases metabolize ester, thioester, carbamate, and amide compounds to more soluble acid, alcohol, and amine products. Amides 62-67 carboxylesterase 2 Homo sapiens 0-17 15100172-1 2004 Carboxylesterases metabolize ester, thioester, carbamate, and amide compounds to more soluble acid, alcohol, and amine products. Alcohols 100-107 carboxylesterase 2 Homo sapiens 0-17 15100172-1 2004 Carboxylesterases metabolize ester, thioester, carbamate, and amide compounds to more soluble acid, alcohol, and amine products. Amines 113-118 carboxylesterase 2 Homo sapiens 0-17 12939466-0 2003 Gene-directed enzyme prodrug therapy for osteosarcoma: sensitization to CPT-11 in vitro and in vivo by adenoviral delivery of a gene encoding secreted carboxylesterase-2. Irinotecan 72-78 carboxylesterase 2 Homo sapiens 151-169 15100172-6 2004 Carboxylesterases metabolize the carbamate prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin (CPT-11; irinotecan) to its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38), a potent topoisomerase I inhibitor. Carbamates 33-42 carboxylesterase 2 Homo sapiens 0-17 15100172-6 2004 Carboxylesterases metabolize the carbamate prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin (CPT-11; irinotecan) to its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38), a potent topoisomerase I inhibitor. Irinotecan 51-117 carboxylesterase 2 Homo sapiens 0-17 15100172-6 2004 Carboxylesterases metabolize the carbamate prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin (CPT-11; irinotecan) to its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38), a potent topoisomerase I inhibitor. Irinotecan hydrochloride 119-125 carboxylesterase 2 Homo sapiens 0-17 15100172-6 2004 Carboxylesterases metabolize the carbamate prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin (CPT-11; irinotecan) to its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38), a potent topoisomerase I inhibitor. Irinotecan 127-137 carboxylesterase 2 Homo sapiens 0-17 15100172-6 2004 Carboxylesterases metabolize the carbamate prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin (CPT-11; irinotecan) to its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38), a potent topoisomerase I inhibitor. Irinotecan 164-194 carboxylesterase 2 Homo sapiens 0-17 15100172-6 2004 Carboxylesterases metabolize the carbamate prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin (CPT-11; irinotecan) to its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38), a potent topoisomerase I inhibitor. Irinotecan 196-201 carboxylesterase 2 Homo sapiens 0-17 15100172-8 2004 In this study, we investigate whether these oxidative metabolites, NPC and APC, can be metabolized to SN-38 by purified human carboxylesterases, CES1A1, CES2, and CES3. Irinotecan 102-107 carboxylesterase 2 Homo sapiens 126-143 15100172-8 2004 In this study, we investigate whether these oxidative metabolites, NPC and APC, can be metabolized to SN-38 by purified human carboxylesterases, CES1A1, CES2, and CES3. Irinotecan 102-107 carboxylesterase 2 Homo sapiens 153-157 15100172-9 2004 We find that CPT-11, APC, and NPC can all be metabolized by carboxylesterases to SN-38. Irinotecan hydrochloride 13-19 carboxylesterase 2 Homo sapiens 60-77 15100172-9 2004 We find that CPT-11, APC, and NPC can all be metabolized by carboxylesterases to SN-38. Irinotecan 81-86 carboxylesterase 2 Homo sapiens 60-77 15100172-10 2004 CES2 has the highest catalytic activity of 0.012 min(-1) microM(-1) among the three carboxylesterases studied for hydrolysis of CPT-11. Irinotecan hydrochloride 128-134 carboxylesterase 2 Homo sapiens 84-101 14515361-0 2003 Cycloheximide and actinomycin D delay death and affect bcl-2, bax, and Ice gene expression in astrocytes under in vitro ischemia. Cycloheximide 0-13 carboxylesterase 2 Homo sapiens 71-74 14515361-0 2003 Cycloheximide and actinomycin D delay death and affect bcl-2, bax, and Ice gene expression in astrocytes under in vitro ischemia. Dactinomycin 18-31 carboxylesterase 2 Homo sapiens 71-74 14581373-9 2003 Only CES2 gene expression correlated with the carboxylesterase activity assays (P < 0.01) with CPT-11 and 4-methylumbelliferyl acetate as substrates. Irinotecan 98-104 carboxylesterase 2 Homo sapiens 5-9 14581373-9 2003 Only CES2 gene expression correlated with the carboxylesterase activity assays (P < 0.01) with CPT-11 and 4-methylumbelliferyl acetate as substrates. 4-methylumbelliferyl acetate 109-137 carboxylesterase 2 Homo sapiens 5-9 14581373-12 2003 CONCLUSIONS: We conclude that CES2 is the most abundant carboxylesterase in colon tumors that is responsible for CPT-11 hydrolysis. Irinotecan 113-119 carboxylesterase 2 Homo sapiens 30-34 14581373-13 2003 This pilot study reinforces the hypothesis that there is a large interindividual variation in expression of carboxylesterases that may contribute to variation in therapeutic outcome and/or toxicity of CPT-11 therapy for colon cancer. Irinotecan 201-207 carboxylesterase 2 Homo sapiens 108-125 12939466-5 2003 GDEPT aims at high production of CE2 at the tumor site, resulting in efficient local conversion of CPT-11 into SN-38. gdept 0-5 carboxylesterase 2 Homo sapiens 33-36 12939466-5 2003 GDEPT aims at high production of CE2 at the tumor site, resulting in efficient local conversion of CPT-11 into SN-38. Irinotecan 99-105 carboxylesterase 2 Homo sapiens 33-36 12939466-5 2003 GDEPT aims at high production of CE2 at the tumor site, resulting in efficient local conversion of CPT-11 into SN-38. Irinotecan 111-116 carboxylesterase 2 Homo sapiens 33-36 12736226-0 2003 Outpatient regimen rituximab plus ifosfamide, carboplatin and etoposide (R-ICE) for relapsed non-Hodgkin"s lymphoma. Etoposide 62-71 carboxylesterase 2 Homo sapiens 75-78 12835618-1 2003 Carboxylesterases are a broad class of enzymes important in the detoxification of many ester- or amide-bond containing xenobiotics. Amides 97-102 carboxylesterase 2 Homo sapiens 0-17 12555875-0 2002 Outpatient intensive chemotherapy for small cell lung cancer: five years experience of modified "ICE" ifosfamide carboplatin and etoposide. ifosfamide carboplatin 102-124 carboxylesterase 2 Homo sapiens 97-100 12607608-9 2002 In the central nervous system, carboxylesterase-2 expression was confined to capillary endothelial cells, consistent with the enzyme having a role to protect the central nervous system from toxic esters and perhaps being a component of a blood-brain barrier system. Esters 196-202 carboxylesterase 2 Homo sapiens 31-49 15618752-1 2003 Twelve novel single nucleotide polymorphisms (SNPs) were found in the CES2 gene from 153 Japanese individuals, who were administered irinotecan or steroidal drugs. Irinotecan 133-143 carboxylesterase 2 Homo sapiens 70-74 12607608-3 2002 Carboxylesterase-2 has been identified as the key enzyme in the metabolic activation of the irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors. Irinotecan 92-102 carboxylesterase 2 Homo sapiens 0-18 12607608-8 2002 The results suggest that liver and gastrointestinal tract with carboxylesterase-2 are likely the most important sites of conversion of irinotecan to the active metabolite SN-38, but carboxylesterase-2 within the other tissues may be contributive to this process. Irinotecan 135-145 carboxylesterase 2 Homo sapiens 63-81 12607608-8 2002 The results suggest that liver and gastrointestinal tract with carboxylesterase-2 are likely the most important sites of conversion of irinotecan to the active metabolite SN-38, but carboxylesterase-2 within the other tissues may be contributive to this process. Irinotecan 171-176 carboxylesterase 2 Homo sapiens 63-81 12669437-2 2002 METHOD: Using polyclonal antibody for ICE gene protein, 73 cases of laryngeal carcinoma, 30 cases dysplasia and 5 cases normal were stained by SP immunohistochemistry. TFF2 protein, human 143-145 carboxylesterase 2 Homo sapiens 38-41 12496014-1 2002 The phenomenon of ice-particle/water mixture blocking flow through a pipeline is a problem that needs to be solved before mixture flow can be applied for practical use in cold energy transportation in a district cooling system. Water 31-36 carboxylesterase 2 Homo sapiens 18-21 12555875-2 2002 The search for an active regimen which can be given with the least toxicity and best outcomes led us to use a modified ICE (Ifosfamide, Carboplatin and Etoposide) regimen and modify it further by using oral mesna instead of intravenous mesna. Ifosfamide 124-134 carboxylesterase 2 Homo sapiens 119-122 12237777-3 2002 An approach to achieve tumour specific activation of CPT-11 is to transduce the cDNA encoding carboxylesterase into tumour cells. Irinotecan 53-59 carboxylesterase 2 Homo sapiens 94-110 12237777-11 2002 Importantly, in combination with CPT-11 both recombinant carboxylesterase proteins exerted strong antiproliferative effects on human colon cancer cells. Irinotecan 33-39 carboxylesterase 2 Homo sapiens 57-73 12171891-5 2002 This scenario raises the possibility that local conversion of irinotecan to SN-38 by CES2 in tumor tissues might occur. Irinotecan 62-72 carboxylesterase 2 Homo sapiens 85-89 12171891-5 2002 This scenario raises the possibility that local conversion of irinotecan to SN-38 by CES2 in tumor tissues might occur. Irinotecan 76-81 carboxylesterase 2 Homo sapiens 85-89 12171891-0 2002 Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan. Irinotecan 100-110 carboxylesterase 2 Homo sapiens 6-24 12171891-10 2002 Liver microsomal CES2 protein expression was significantly correlated with irinotecan activation to SN-38 (R(s) = 0.70; P = 0.007). Irinotecan 75-85 carboxylesterase 2 Homo sapiens 17-21 12171891-10 2002 Liver microsomal CES2 protein expression was significantly correlated with irinotecan activation to SN-38 (R(s) = 0.70; P = 0.007). Irinotecan 100-105 carboxylesterase 2 Homo sapiens 17-21 12171891-11 2002 This study confirms that CES2 is a key enzyme for irinotecan activation. Irinotecan 50-60 carboxylesterase 2 Homo sapiens 25-29 12171891-12 2002 Tumor CES2 expression may contribute to variable response to irinotecan chemotherapy for solid tumors. Irinotecan 61-71 carboxylesterase 2 Homo sapiens 6-10 12171903-2 2002 We reported recently that human carboxylesterase-2 (hCE-2) is a higher-affinity, higher-velocity enzyme for irinotecan hydrolysis when compared with hCE-1. Irinotecan 108-118 carboxylesterase 2 Homo sapiens 32-50 12171903-2 2002 We reported recently that human carboxylesterase-2 (hCE-2) is a higher-affinity, higher-velocity enzyme for irinotecan hydrolysis when compared with hCE-1. Irinotecan 108-118 carboxylesterase 2 Homo sapiens 52-57 12171903-4 2002 Extracts of HT29 cells transfected with hCE-2 exhibited significantly higher irinotecan hydrolysis (5.2 pmol/mg protein/hr) than hCE-1 (1.0 pmol/mg protein/hr). Irinotecan 77-87 carboxylesterase 2 Homo sapiens 40-45 12171903-5 2002 HT29 cells over-expressing hCE-2 were more sensitive to the toxic effects of irinotecan than cells expressing hCE-1 (EC50 = 0.3 micro M and 6.8 micro M, respectively). Irinotecan 77-87 carboxylesterase 2 Homo sapiens 27-32 12171903-6 2002 Our data further support the notion that hCE-2 plays a substantial role in irinotecan activation in human tissue at relevant pharmacologic concentrations. Irinotecan 75-85 carboxylesterase 2 Homo sapiens 41-46 12042984-29 2002 Therapy with a similar regimen, combining ifosfamide, carboplatin, and etoposide in standard doses (ICE) has also been described. Etoposide 71-80 carboxylesterase 2 Homo sapiens 100-103 12215019-5 2002 Another risk factor of infection was the HD-ICE regimen (ifosfamide, carboplatin, etoposide) given to patients with solid tumors (OR, 8.00; 95% confidence interval, 1.61-39.7). Ifosfamide 57-67 carboxylesterase 2 Homo sapiens 44-47 12215019-5 2002 Another risk factor of infection was the HD-ICE regimen (ifosfamide, carboplatin, etoposide) given to patients with solid tumors (OR, 8.00; 95% confidence interval, 1.61-39.7). Carboplatin 69-80 carboxylesterase 2 Homo sapiens 44-47 12215019-5 2002 Another risk factor of infection was the HD-ICE regimen (ifosfamide, carboplatin, etoposide) given to patients with solid tumors (OR, 8.00; 95% confidence interval, 1.61-39.7). Etoposide 82-91 carboxylesterase 2 Homo sapiens 44-47 12096909-11 2002 Our findings are discussed in comparison with serine esterases and, in particular, with cocaine esterase (cocE), which possesses a tyrosine based oxyanion hole. Tyrosine 131-139 carboxylesterase 2 Homo sapiens 88-104 12096909-11 2002 Our findings are discussed in comparison with serine esterases and, in particular, with cocaine esterase (cocE), which possesses a tyrosine based oxyanion hole. Tyrosine 131-139 carboxylesterase 2 Homo sapiens 106-110 12405438-6 2002 After decortication, chemotherapy with ICE (ifosfamide, carboplatin, etoposide) - VAC (vincristine, adriamycin, cyclophosphamide) combination was started. vinyl acetate 82-85 carboxylesterase 2 Homo sapiens 39-42 11839882-3 2002 Subsequently, a prospective randomized study was done comparing the conventional (group A) and ICE guided (group B) ablation of the SP. sp 132-134 carboxylesterase 2 Homo sapiens 95-98 11950785-7 2002 All carboxylesterases hydrolyzed para-nitrophenylacetate and para-nitrophenylbutyrate. 4-nitrophenyl acetate 33-56 carboxylesterase 2 Homo sapiens 4-21 11950785-7 2002 All carboxylesterases hydrolyzed para-nitrophenylacetate and para-nitrophenylbutyrate. 4-nitrophenyl butyrate 61-85 carboxylesterase 2 Homo sapiens 4-21 11950785-9 2002 Carboxylesterases with the same functional subsites had a similar profile on substrate specificity and sensitivity toward phenylmethylsulfonyl fluoride (PMSF) and paraoxon, suggesting that these subsites play determinant roles in the recognition of substrates and inhibitors. Phenylmethylsulfonyl Fluoride 122-151 carboxylesterase 2 Homo sapiens 0-17 11950785-9 2002 Carboxylesterases with the same functional subsites had a similar profile on substrate specificity and sensitivity toward phenylmethylsulfonyl fluoride (PMSF) and paraoxon, suggesting that these subsites play determinant roles in the recognition of substrates and inhibitors. Phenylmethylsulfonyl Fluoride 153-157 carboxylesterase 2 Homo sapiens 0-17 11950785-9 2002 Carboxylesterases with the same functional subsites had a similar profile on substrate specificity and sensitivity toward phenylmethylsulfonyl fluoride (PMSF) and paraoxon, suggesting that these subsites play determinant roles in the recognition of substrates and inhibitors. Paraoxon 163-171 carboxylesterase 2 Homo sapiens 0-17 11950785-10 2002 Among three human carboxylesterases, HCE-1 hydrolyzed both substrates to a similar extent, whereas HCE-2 and HCE-3 showed an opposite substrate preference. HCE 37-40 carboxylesterase 2 Homo sapiens 18-35 11486402-4 2001 Further dose intensification of ICE may be achieved with acceptable toxicity by adding further drugs (e.g. anthracyclines) or by treatment with sequential cycles of ICE (Tandem-HDCT). Anthracyclines 107-121 carboxylesterase 2 Homo sapiens 32-35 12803126-1 2002 BACKGROUND: Big ICE chemotherapy (consisting of Idarubicin, high dose Cytosine arabinoside and Etoposide), has proven its efficacy in the treatment of patients with relapse/refractory acute myeloblastic leukemia. Idarubicin 48-58 carboxylesterase 2 Homo sapiens 16-19 12803126-1 2002 BACKGROUND: Big ICE chemotherapy (consisting of Idarubicin, high dose Cytosine arabinoside and Etoposide), has proven its efficacy in the treatment of patients with relapse/refractory acute myeloblastic leukemia. Cytarabine 70-90 carboxylesterase 2 Homo sapiens 16-19 12803126-1 2002 BACKGROUND: Big ICE chemotherapy (consisting of Idarubicin, high dose Cytosine arabinoside and Etoposide), has proven its efficacy in the treatment of patients with relapse/refractory acute myeloblastic leukemia. Etoposide 95-104 carboxylesterase 2 Homo sapiens 16-19 11995407-2 2002 PATIENTS AND METHODS: Thirty-five consecutive patients received high dose chemotherapy with ifosfamide, etoposide and carboplatin (ICE) and autologous PBSC transplant. Carboplatin 118-129 carboxylesterase 2 Homo sapiens 131-134 11716702-7 2001 hCE-2 was 26-fold more active than human carboxylesterase 1 and was 65% as active as rabbit liver carboxylesterase, the most active CPT-11 hydrolyzing enzyme known. Irinotecan 132-138 carboxylesterase 2 Homo sapiens 0-5 11716702-8 2001 The anti-p97 mAb 96.5 was linked to hCE-2, forming a conjugate that could bind to antigen-positive cancer cells and convert CPT-11 to SN-38. Irinotecan 124-130 carboxylesterase 2 Homo sapiens 36-41 11716702-8 2001 The anti-p97 mAb 96.5 was linked to hCE-2, forming a conjugate that could bind to antigen-positive cancer cells and convert CPT-11 to SN-38. Irinotecan 134-139 carboxylesterase 2 Homo sapiens 36-41 11589488-0 2001 Three conventional-drug combination (ifosfamide, carboplatin, etoposide--ICE regimen) in advanced non-small cell lung cancer (NSCLC). Etoposide 62-71 carboxylesterase 2 Homo sapiens 73-76 11486402-5 2001 More convenient drug formulations (e.g. etoposide phosphate) might further improve the therapeutic index of ICE. etoposide phosphate 40-59 carboxylesterase 2 Homo sapiens 108-111 10640517-4 2000 Exposure of cultured rat hepatocytes to nanomolar levels of dexamethasone markedly decreased the levels of immunoreactive proteins of hydrolase A, B, and C. In contrast, exposure of cultured human hepatocytes to dexamethasone caused a slight increase in HCE-1 and HCE-2, two major forms of human liver microsomal carboxylesterases. Dexamethasone 60-73 carboxylesterase 2 Homo sapiens 264-269 10729262-3 2000 By shock-freezing, an ice structure could be produced which featured streak-like porous channels of diameters of up to 300 &mgr;m allowing almost unrestricted self-diffusion along one preferential axis but reduced diffusivities in the remaining directions. Adenosine Monophosphate 124-127 carboxylesterase 2 Homo sapiens 22-25 10729262-4 2000 In ice grown under controlled conditions, the pore sizes are near the resolution limit of the imaging experiment of typically 50 &mgr;m. For this type of samples, strongly non-Gaussian self-diffusion propagators are obtained, indicating restricted self-diffusion on rms scales of 30 &mgr;m. Common to all samples was the observation of highly anisotropic self-diffusion. Adenosine Monophosphate 130-133 carboxylesterase 2 Homo sapiens 3-6 10729262-4 2000 In ice grown under controlled conditions, the pore sizes are near the resolution limit of the imaging experiment of typically 50 &mgr;m. For this type of samples, strongly non-Gaussian self-diffusion propagators are obtained, indicating restricted self-diffusion on rms scales of 30 &mgr;m. Common to all samples was the observation of highly anisotropic self-diffusion. Adenosine Monophosphate 159-162 carboxylesterase 2 Homo sapiens 3-6 10677462-0 2000 Was a change in thermohaline circulation responsible for the Little Ice Age? thermohaline 16-28 carboxylesterase 2 Homo sapiens 68-71 11177741-4 2001 Preliminary data suggest that gene expression levels of topoisomerase I, p21, bcl-2, and ICE may be predictive of response to therapy with CPT-11. Irinotecan 139-145 carboxylesterase 2 Homo sapiens 89-92 10728672-4 2000 hCE-2 has a 12.5-fold higher affinity for CPT-11 and a 5-fold higher maximal rate of CPT-11 hydrolysis when compared with hCE-1. Irinotecan 42-48 carboxylesterase 2 Homo sapiens 0-5 10728672-4 2000 hCE-2 has a 12.5-fold higher affinity for CPT-11 and a 5-fold higher maximal rate of CPT-11 hydrolysis when compared with hCE-1. Irinotecan 85-91 carboxylesterase 2 Homo sapiens 0-5 10728672-5 2000 In cytotoxicity assays, incubation of 1 microM CPT-11 with hCE-2 (3.6 microg/ml) resulted in a 60% reduction in survival of SQ20b cells. Irinotecan 47-53 carboxylesterase 2 Homo sapiens 59-64 10728672-8 2000 hCE-2 likely plays a substantial role in CPT-11 activation in human liver at relevant pharmacological concentrations. Irinotecan 41-47 carboxylesterase 2 Homo sapiens 0-5 10456673-7 1999 GC induced delta psi(m) disruption can be inhibited by the ICE-like inhibitor zVAD-fmk but not by ICE inhibitor tetrapeptide acetyl-Tyr-Val-Ala-Asp.chloromethylketone (YVAD-cmk) nor by caspase-3 inhibitor zDEVD. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 78-86 carboxylesterase 2 Homo sapiens 59-62 10697531-7 1999 Under serum-deficient culture conditions, addition of the CPP32 inhibitor DEVD or the ICE inhibitor YVAD enhanced cell growth but did not abolish the DBcAMP-induced growth inhibition. YVAD 100-104 carboxylesterase 2 Homo sapiens 86-89 10642996-5 2000 After the operation, we treated him with additional radiation and chemotherapy using ifosfamide, cisplatin, and etoposide (namely ICE therapy). Etoposide 112-121 carboxylesterase 2 Homo sapiens 130-133 10577849-1 1999 PURPOSE: To evaluate a chemotherapy regimen that consisted of ifosfamide administered as an infusion with bolus carboplatin, and etoposide (ICE) supported by granulocyte colony-stimulating factor (G-CSF) for cytoreduction and stem-cell mobilization in transplant-eligible patients with primary refractory or relapsed non-Hodgkin"s lymphoma (NHL). Etoposide 129-138 carboxylesterase 2 Homo sapiens 140-143 10456673-7 1999 GC induced delta psi(m) disruption can be inhibited by the ICE-like inhibitor zVAD-fmk but not by ICE inhibitor tetrapeptide acetyl-Tyr-Val-Ala-Asp.chloromethylketone (YVAD-cmk) nor by caspase-3 inhibitor zDEVD. N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone 168-176 carboxylesterase 2 Homo sapiens 59-62 10456673-7 1999 GC induced delta psi(m) disruption can be inhibited by the ICE-like inhibitor zVAD-fmk but not by ICE inhibitor tetrapeptide acetyl-Tyr-Val-Ala-Asp.chloromethylketone (YVAD-cmk) nor by caspase-3 inhibitor zDEVD. zdevd 205-210 carboxylesterase 2 Homo sapiens 59-62 10381793-2 1999 Two carboxylesterases, hCE-1 and hCE-2, have been purified and characterized with respect to their role in cocaine and heroin hydrolysis. Cocaine 107-114 carboxylesterase 2 Homo sapiens 33-38 10457478-2 1999 The ICE separation was used as a pretreatment step to isolate the contaminant anions of strong acid from the excess of matrix ions. strong acid 88-99 carboxylesterase 2 Homo sapiens 4-7 10064623-5 1999 Here we report that the stable carbon and nitrogen isotope values for the hair of the 5200 year-old Ice Man indicates a primarily vegetarian diet, in agreement with his dental wear pattern. Nitrogen 42-50 carboxylesterase 2 Homo sapiens 100-103 10354146-1 1999 We studied the effects of an intensified induction/consolidation treatment containing fludarabine (ICE/FLAN/FLAN) on the mobilization and collection of peripheral blood stem cells (PBSC) in 31 consecutive untreated acute myeloid leukaemia (AML) patients. fludarabine 86-97 carboxylesterase 2 Homo sapiens 99-102 10064623-0 1999 The Ice Man"s diet as reflected by the stable nitrogen and carbon isotopic composition of his hair. Nitrogen 46-54 carboxylesterase 2 Homo sapiens 4-7 10064623-0 1999 The Ice Man"s diet as reflected by the stable nitrogen and carbon isotopic composition of his hair. Carbon 59-65 carboxylesterase 2 Homo sapiens 4-7 10064623-5 1999 Here we report that the stable carbon and nitrogen isotope values for the hair of the 5200 year-old Ice Man indicates a primarily vegetarian diet, in agreement with his dental wear pattern. Carbon 31-37 carboxylesterase 2 Homo sapiens 100-103 10221868-3 1999 METHODS: High-dose chemotherapy was then given with ICE (ifosfamide, carboplatin, etoposide) from days -7 to-3. Ifosfamide 57-67 carboxylesterase 2 Homo sapiens 52-55 10216478-1 1999 BACKGROUND: We investigated the feasibility and efficacy of high-dose chemotherapy consisting of ifosfamide, carboplatin and etoposide (HD-ICE) facilitated by autologous peripheral blood progenitor cell transplantation (ABPCT) for the treatment of small-cell lung cancer (SCLC). Ifosfamide 97-107 carboxylesterase 2 Homo sapiens 139-142 10216478-1 1999 BACKGROUND: We investigated the feasibility and efficacy of high-dose chemotherapy consisting of ifosfamide, carboplatin and etoposide (HD-ICE) facilitated by autologous peripheral blood progenitor cell transplantation (ABPCT) for the treatment of small-cell lung cancer (SCLC). Etoposide 125-134 carboxylesterase 2 Homo sapiens 139-142 9856942-1 1998 For temperatures warmer than Tc, brine carrying heat and nutrients can move through the ice, whereas for colder temperatures the ice is impermeable. Technetium 30-32 carboxylesterase 2 Homo sapiens 89-92 9876059-0 1998 Phase II study with ifosfamide, carboplatin, etoposide (ICE regimen) at intermediate dosage for advanced non small cell lung cancer (NSCLC). Ifosfamide 20-30 carboxylesterase 2 Homo sapiens 56-59 9885442-0 1998 Toxicity and efficacy of ifosfamide, carboplatin and etoposide (modified ICE) as a salvage chemotherapy in Japanese patients with relapsed or refractory aggressive non-Hodgkin"s lymphoma. Ifosfamide 25-35 carboxylesterase 2 Homo sapiens 73-76 9885442-0 1998 Toxicity and efficacy of ifosfamide, carboplatin and etoposide (modified ICE) as a salvage chemotherapy in Japanese patients with relapsed or refractory aggressive non-Hodgkin"s lymphoma. Etoposide 53-62 carboxylesterase 2 Homo sapiens 73-76 9885442-1 1998 The combination of ifosfamide, carboplatin and etoposide (modified ICE), was evaluated for its toxicity and activity in relapsed or refractory aggressive non-Hodgkin"s lymphoma. Etoposide 47-56 carboxylesterase 2 Homo sapiens 67-70 9876059-0 1998 Phase II study with ifosfamide, carboplatin, etoposide (ICE regimen) at intermediate dosage for advanced non small cell lung cancer (NSCLC). Etoposide 45-54 carboxylesterase 2 Homo sapiens 56-59 9876059-1 1998 We have evaluated the combination of ifosfamide, carboplatin and etoposide (ICE regimen) along with mesna in 26 previously untreated patients with non small cell lung cancer (NSCLC). Ifosfamide 37-47 carboxylesterase 2 Homo sapiens 76-79 9876059-1 1998 We have evaluated the combination of ifosfamide, carboplatin and etoposide (ICE regimen) along with mesna in 26 previously untreated patients with non small cell lung cancer (NSCLC). Etoposide 65-74 carboxylesterase 2 Homo sapiens 76-79 9829545-0 1998 Modified ice study: a phase II study of an intensive, modified ICE regimen (ifosfamide, carboplatin and etoposide) in patients with better prognosis, small cell lung cancer. Ifosfamide 76-86 carboxylesterase 2 Homo sapiens 63-66 9873533-2 1998 Combinatorial arrays were performed using the optimized conditions to synthesize 590 new compounds which were tested for inhibition against N-His (D381E) ICE. n-his 140-145 carboxylesterase 2 Homo sapiens 154-157 9829545-1 1998 A total of 30 with good prognosis small cell lung cancer were treated with a modified "ICE" (ifosfamide, carboplatin and etoposide) chemotherapy regimen in an attempt to achieve a high response rate with less toxicity than is seen with the full "ICE" regimen. Ifosfamide 93-103 carboxylesterase 2 Homo sapiens 87-90 9542724-5 1998 In the present paper, we elaborate on the thesis that the neurodegenerative effects of two drugs, namely methamphetamine (METH, ICE) and methylenedioxymethamphetamine (MDMA, Ecstasy) are due to ROS overproduction in monoaminergic systems in the brain. Methamphetamine 105-120 carboxylesterase 2 Homo sapiens 128-131 9542724-5 1998 In the present paper, we elaborate on the thesis that the neurodegenerative effects of two drugs, namely methamphetamine (METH, ICE) and methylenedioxymethamphetamine (MDMA, Ecstasy) are due to ROS overproduction in monoaminergic systems in the brain. Reactive Oxygen Species 194-197 carboxylesterase 2 Homo sapiens 128-131 14555970-2 1997 As previously shown, CrmA strongly inhibited ICE-induced apoptosis but was ineffective against Nedd2- or CPP32-mediated apoptosis. crma 21-25 carboxylesterase 2 Homo sapiens 45-48 9300133-0 1997 Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver. Esters 23-28 carboxylesterase 2 Homo sapiens 50-67 9300133-0 1997 Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver. Amides 33-38 carboxylesterase 2 Homo sapiens 50-67 9300133-1 1997 Carboxylesterases (EC 3.1.1.1) from human liver were purified using Q-Sepharose, Sephadex G-150, isoelectrofocusing and Con A-Sepharose. q-sepharose 68-79 carboxylesterase 2 Homo sapiens 0-17 9300133-1 1997 Carboxylesterases (EC 3.1.1.1) from human liver were purified using Q-Sepharose, Sephadex G-150, isoelectrofocusing and Con A-Sepharose. sephadex 81-95 carboxylesterase 2 Homo sapiens 0-17 9300133-1 1997 Carboxylesterases (EC 3.1.1.1) from human liver were purified using Q-Sepharose, Sephadex G-150, isoelectrofocusing and Con A-Sepharose. Sepharose 70-79 carboxylesterase 2 Homo sapiens 0-17 9257710-1 1997 Treatment of U937 cells with dolichyl phosphate led to an increase in the activity of the ICE family protease CPP32, accompanied with cleavage of pre-CPP32 to generate p17. dolichol monophosphate 29-47 carboxylesterase 2 Homo sapiens 90-93 9257710-2 1997 Peptide inhibitors YVAD-cmk and Z-Asp-CH2-DCB (specific to ICE) and DEVD-CHO (specific to CPP32) blocked the dolichyl phosphate-induced apoptosis. benzyloxycarbonyl-Asp-CH2OC(O)-2,6-dichlorobenzene 32-45 carboxylesterase 2 Homo sapiens 59-62 9257710-2 1997 Peptide inhibitors YVAD-cmk and Z-Asp-CH2-DCB (specific to ICE) and DEVD-CHO (specific to CPP32) blocked the dolichyl phosphate-induced apoptosis. dolichol monophosphate 109-127 carboxylesterase 2 Homo sapiens 59-62 9144407-3 1997 The deduced amino-acid sequence contains many structural features, that are highly conserved among all carboxylesterase isoenzymes, like the serine esterase active site, an ER-retention signal and one Asn-Xxx-Thr site for N-linked carbohydrate addition. Asparagine 201-204 carboxylesterase 2 Homo sapiens 103-119 9169443-1 1997 A human liver carboxylesterase (hCE-2) that catalyzes the hydrolysis of the benzoyl group of cocaine and the acetyl groups of 4-methylumbelliferyl acetate, heroin, and 6-monoacetylmorphine was purified from human liver. Cocaine 93-100 carboxylesterase 2 Homo sapiens 32-37 9169443-1 1997 A human liver carboxylesterase (hCE-2) that catalyzes the hydrolysis of the benzoyl group of cocaine and the acetyl groups of 4-methylumbelliferyl acetate, heroin, and 6-monoacetylmorphine was purified from human liver. 4-methylumbelliferyl acetate 126-154 carboxylesterase 2 Homo sapiens 32-37 9169443-1 1997 A human liver carboxylesterase (hCE-2) that catalyzes the hydrolysis of the benzoyl group of cocaine and the acetyl groups of 4-methylumbelliferyl acetate, heroin, and 6-monoacetylmorphine was purified from human liver. Heroin 156-162 carboxylesterase 2 Homo sapiens 32-37 9169443-1 1997 A human liver carboxylesterase (hCE-2) that catalyzes the hydrolysis of the benzoyl group of cocaine and the acetyl groups of 4-methylumbelliferyl acetate, heroin, and 6-monoacetylmorphine was purified from human liver. 6-O-monoacetylmorphine 168-188 carboxylesterase 2 Homo sapiens 32-37 9169443-10 1997 hCE-2 exhibited different drug ester substrate specificity from the human liver carboxylesterase called hCE-1, which hydrolyzes the methyl ester of cocaine. Esters 31-36 carboxylesterase 2 Homo sapiens 0-5 9169443-10 1997 hCE-2 exhibited different drug ester substrate specificity from the human liver carboxylesterase called hCE-1, which hydrolyzes the methyl ester of cocaine. methyl ester 132-144 carboxylesterase 2 Homo sapiens 0-5 9169443-10 1997 hCE-2 exhibited different drug ester substrate specificity from the human liver carboxylesterase called hCE-1, which hydrolyzes the methyl ester of cocaine. Cocaine 148-155 carboxylesterase 2 Homo sapiens 0-5 9169443-11 1997 hCE-2 had higher catalytic efficiencies for hydrolysis of 4-methylumbelliferyl acetate, heroin, and 6-monoacetylmorphine and greater inhibition by eserine than hCE-1. 4-methylumbelliferyl acetate 58-86 carboxylesterase 2 Homo sapiens 0-5 9169443-11 1997 hCE-2 had higher catalytic efficiencies for hydrolysis of 4-methylumbelliferyl acetate, heroin, and 6-monoacetylmorphine and greater inhibition by eserine than hCE-1. Heroin 88-94 carboxylesterase 2 Homo sapiens 0-5 9169443-11 1997 hCE-2 had higher catalytic efficiencies for hydrolysis of 4-methylumbelliferyl acetate, heroin, and 6-monoacetylmorphine and greater inhibition by eserine than hCE-1. 6-O-monoacetylmorphine 100-120 carboxylesterase 2 Homo sapiens 0-5 9169443-12 1997 hCE-2 may play an important role in the degradation of cocaine and heroin in human tissues. Cocaine 55-62 carboxylesterase 2 Homo sapiens 0-5 9169443-12 1997 hCE-2 may play an important role in the degradation of cocaine and heroin in human tissues. Heroin 67-73 carboxylesterase 2 Homo sapiens 0-5 9329558-3 1997 These trials were extended to 2 sequential phase II investigations of WBH plus ifosfamide, carboplatin and etoposide (ICE) for refractory sarcoma patients. Etoposide 107-116 carboxylesterase 2 Homo sapiens 118-121 9129045-10 1997 Incubation of B-CLL cells with the CED-3/ICE-like protease inhibitor Z-VAD.fmk inhibited spontaneous and dexamethasone-induced PARP cleavage and DNA fragmentation in a dose-dependent manner. z-vad 69-74 carboxylesterase 2 Homo sapiens 41-44 9129045-10 1997 Incubation of B-CLL cells with the CED-3/ICE-like protease inhibitor Z-VAD.fmk inhibited spontaneous and dexamethasone-induced PARP cleavage and DNA fragmentation in a dose-dependent manner. FMK 75-78 carboxylesterase 2 Homo sapiens 41-44 9129045-10 1997 Incubation of B-CLL cells with the CED-3/ICE-like protease inhibitor Z-VAD.fmk inhibited spontaneous and dexamethasone-induced PARP cleavage and DNA fragmentation in a dose-dependent manner. Dexamethasone 105-118 carboxylesterase 2 Homo sapiens 41-44 9103193-3 1997 Model results show that of the 40 teragrams of carbon produced annually in the Antarctic ice pack, 75 percent was associated with first-year ice and nearly 50 percent was produced in the Weddell Sea. Carbon 47-53 carboxylesterase 2 Homo sapiens 89-92 9103193-3 1997 Model results show that of the 40 teragrams of carbon produced annually in the Antarctic ice pack, 75 percent was associated with first-year ice and nearly 50 percent was produced in the Weddell Sea. Carbon 47-53 carboxylesterase 2 Homo sapiens 141-144 9144407-3 1997 The deduced amino-acid sequence contains many structural features, that are highly conserved among all carboxylesterase isoenzymes, like the serine esterase active site, an ER-retention signal and one Asn-Xxx-Thr site for N-linked carbohydrate addition. Threonine 209-212 carboxylesterase 2 Homo sapiens 103-119 9144407-3 1997 The deduced amino-acid sequence contains many structural features, that are highly conserved among all carboxylesterase isoenzymes, like the serine esterase active site, an ER-retention signal and one Asn-Xxx-Thr site for N-linked carbohydrate addition. n-linked carbohydrate 222-243 carboxylesterase 2 Homo sapiens 103-119 8930175-6 1996 Pseudocholinesterase and two human liver carboxylesterases [human liver carboxylesterase form 1 (hCE-1) and human liver carboxylesterase form 2 (hCE-2)] catalyze the rapid hydrolysis of ester linkages in cocaine. Esters 12-17 carboxylesterase 2 Homo sapiens 145-150 16465208-6 1997 Here, we demonstrate that CPP32/Yama/Apopain, a member of the ICE/Ced-3 gene family, is processed during staurosporine-induced apoptosis in HeLa cells and that concomitant with CPP32 activation, two other proteins, poly (ADP-ribose) polymerase (PARP) and the U1-70 K small ribonucleoprotein, also undergo proteolysis. Staurosporine 105-118 carboxylesterase 2 Homo sapiens 62-65 8930175-6 1996 Pseudocholinesterase and two human liver carboxylesterases [human liver carboxylesterase form 1 (hCE-1) and human liver carboxylesterase form 2 (hCE-2)] catalyze the rapid hydrolysis of ester linkages in cocaine. Cocaine 204-211 carboxylesterase 2 Homo sapiens 145-150 8930175-10 1996 The catalytic efficiency, under first-order conditions, for hCE-2-catalyzed formation of 6-monoacetylmorphine (314 min-1 mM-1) was much greater than that for either hCE-1 or pseudocholinesterase (69 and 4 min-1 mM-1, respectively). 6-O-monoacetylmorphine 89-109 carboxylesterase 2 Homo sapiens 60-65 8930175-11 1996 Similarly, the catalytic efficiency for hydrolysis of 6-monoacetylmorphine to morphine by hCE-2 (22 min-1 mM-1) was substantially greater than that for hCE-1 (0.024 min-1 mM-1). 6-O-monoacetylmorphine 54-74 carboxylesterase 2 Homo sapiens 90-95 8930175-7 1996 This investigation examined the relative catalytic efficiencies of hCE-1, hCE-2 and pseudocholinesterase for heroin metabolism and compared them with cocaine hydrolysis. Heroin 109-115 carboxylesterase 2 Homo sapiens 74-104 8930175-11 1996 Similarly, the catalytic efficiency for hydrolysis of 6-monoacetylmorphine to morphine by hCE-2 (22 min-1 mM-1) was substantially greater than that for hCE-1 (0.024 min-1 mM-1). Morphine 66-74 carboxylesterase 2 Homo sapiens 90-95 8930175-12 1996 Cocaine competitively inhibited hCE-1-, hCE-2- and pseudocholinesterase-catalyzed hydrolysis of heroin to 6-monoacetylmorphine (Ki = 530, 460 and 130 microM, respectively) and 6-monoacetylmorphine hydrolysis to morphine (Ki = 710, 220 and 830 microM, respectively). Cocaine 0-7 carboxylesterase 2 Homo sapiens 40-71 8930175-9 1996 All three enzymes rapidly catalyzed hydrolysis of heroin to 6-monoacetylmorphine (hCE-1 kcat = 439 min-1, hCE-2 kcat = 2186 min-1 and pseudocholinesterase kcat = 13 min-1). Heroin 50-56 carboxylesterase 2 Homo sapiens 106-111 8930175-12 1996 Cocaine competitively inhibited hCE-1-, hCE-2- and pseudocholinesterase-catalyzed hydrolysis of heroin to 6-monoacetylmorphine (Ki = 530, 460 and 130 microM, respectively) and 6-monoacetylmorphine hydrolysis to morphine (Ki = 710, 220 and 830 microM, respectively). Heroin 96-102 carboxylesterase 2 Homo sapiens 40-71 8930175-9 1996 All three enzymes rapidly catalyzed hydrolysis of heroin to 6-monoacetylmorphine (hCE-1 kcat = 439 min-1, hCE-2 kcat = 2186 min-1 and pseudocholinesterase kcat = 13 min-1). 6-O-monoacetylmorphine 60-80 carboxylesterase 2 Homo sapiens 106-111 8930175-12 1996 Cocaine competitively inhibited hCE-1-, hCE-2- and pseudocholinesterase-catalyzed hydrolysis of heroin to 6-monoacetylmorphine (Ki = 530, 460 and 130 microM, respectively) and 6-monoacetylmorphine hydrolysis to morphine (Ki = 710, 220 and 830 microM, respectively). 6-O-monoacetylmorphine 106-126 carboxylesterase 2 Homo sapiens 40-71 8930175-12 1996 Cocaine competitively inhibited hCE-1-, hCE-2- and pseudocholinesterase-catalyzed hydrolysis of heroin to 6-monoacetylmorphine (Ki = 530, 460 and 130 microM, respectively) and 6-monoacetylmorphine hydrolysis to morphine (Ki = 710, 220 and 830 microM, respectively). 6-O-monoacetylmorphine 176-196 carboxylesterase 2 Homo sapiens 40-71 8899175-0 1996 The ICE regimen (ifosfamide, carboplatin, etoposide) for the treatment of germ-cell tumors and metastatic trophoblastic disease. Ifosfamide 17-27 carboxylesterase 2 Homo sapiens 4-7 8930175-12 1996 Cocaine competitively inhibited hCE-1-, hCE-2- and pseudocholinesterase-catalyzed hydrolysis of heroin to 6-monoacetylmorphine (Ki = 530, 460 and 130 microM, respectively) and 6-monoacetylmorphine hydrolysis to morphine (Ki = 710, 220 and 830 microM, respectively). Morphine 118-126 carboxylesterase 2 Homo sapiens 40-71 8930175-14 1996 The role of hepatic hCE-2 is particularly important for the hydrolysis of heroin to 6-monoacetylmorphine and of 6-monoacetylmorphine to morphine. Heroin 74-80 carboxylesterase 2 Homo sapiens 20-25 8930175-14 1996 The role of hepatic hCE-2 is particularly important for the hydrolysis of heroin to 6-monoacetylmorphine and of 6-monoacetylmorphine to morphine. 6-O-monoacetylmorphine 84-104 carboxylesterase 2 Homo sapiens 20-25 8930175-14 1996 The role of hepatic hCE-2 is particularly important for the hydrolysis of heroin to 6-monoacetylmorphine and of 6-monoacetylmorphine to morphine. 6-O-monoacetylmorphine 112-132 carboxylesterase 2 Homo sapiens 20-25 8930175-14 1996 The role of hepatic hCE-2 is particularly important for the hydrolysis of heroin to 6-monoacetylmorphine and of 6-monoacetylmorphine to morphine. Morphine 96-104 carboxylesterase 2 Homo sapiens 20-25 8899175-0 1996 The ICE regimen (ifosfamide, carboplatin, etoposide) for the treatment of germ-cell tumors and metastatic trophoblastic disease. Carboplatin 29-40 carboxylesterase 2 Homo sapiens 4-7 8899175-0 1996 The ICE regimen (ifosfamide, carboplatin, etoposide) for the treatment of germ-cell tumors and metastatic trophoblastic disease. Etoposide 42-51 carboxylesterase 2 Homo sapiens 4-7 8692933-5 1996 Water (ice) was recognized early as a potential matrix because of its strong O-H stretching mode near 3 microm. Water 0-5 carboxylesterase 2 Homo sapiens 7-10 8649764-5 1996 Induction of necrotic cell death by KCN also induces activation of ICE(-like) proteases but not of CPP32/Yama(-like) proteases, and Bcl-2 and Bcl-xL inhibit the activation and the cell death, suggesting that the functional site of Bcl-2 and Bcl-xL is also upstream of ICE(-like) proteases in at least some forms of necrosis. Potassium Cyanide 36-39 carboxylesterase 2 Homo sapiens 67-70 8700549-1 1996 Bcl-2, Bcl-xL, CrmA and tetrapeptide ICE inhibitor reduce the extent of necrotic cell death induced by cyanide, which primarily damages mitochondria. Cyanides 103-110 carboxylesterase 2 Homo sapiens 37-40 8649764-5 1996 Induction of necrotic cell death by KCN also induces activation of ICE(-like) proteases but not of CPP32/Yama(-like) proteases, and Bcl-2 and Bcl-xL inhibit the activation and the cell death, suggesting that the functional site of Bcl-2 and Bcl-xL is also upstream of ICE(-like) proteases in at least some forms of necrosis. Potassium Cyanide 36-39 carboxylesterase 2 Homo sapiens 268-271 7602350-1 1995 PURPOSE: A phase II study of ifosfamide, carboplatin, and prolonged oral administration of etoposide (ICE) in patients with untreated extensive-disease (ED) small-cell lung cancer (SCLC) was conducted to assess toxicities, response, and median survival. Etoposide 91-100 carboxylesterase 2 Homo sapiens 102-105 8677446-6 1996 Maximum tolerated doses of the ICE regimen in these trials are 16 to 20.1 g/m2 ifosfamide, 1.8 g/m2 carboplatin, and 1.2 to 3.0 g/m2 etoposide. Ifosfamide 79-89 carboxylesterase 2 Homo sapiens 31-34 8677446-6 1996 Maximum tolerated doses of the ICE regimen in these trials are 16 to 20.1 g/m2 ifosfamide, 1.8 g/m2 carboplatin, and 1.2 to 3.0 g/m2 etoposide. Carboplatin 100-111 carboxylesterase 2 Homo sapiens 31-34 8677446-6 1996 Maximum tolerated doses of the ICE regimen in these trials are 16 to 20.1 g/m2 ifosfamide, 1.8 g/m2 carboplatin, and 1.2 to 3.0 g/m2 etoposide. Etoposide 133-142 carboxylesterase 2 Homo sapiens 31-34 8677454-2 1996 The ICE combination (ifosfamide/carboplatin [or cisplatin]/etoposide) has been studied in breast cancer, small cell and non-small cell lung cancer, testicular cancer, lymphoma, and other malignancies with promising results. Ifosfamide 21-31 carboxylesterase 2 Homo sapiens 4-7 8677454-2 1996 The ICE combination (ifosfamide/carboplatin [or cisplatin]/etoposide) has been studied in breast cancer, small cell and non-small cell lung cancer, testicular cancer, lymphoma, and other malignancies with promising results. Carboplatin 32-43 carboxylesterase 2 Homo sapiens 4-7 8677454-2 1996 The ICE combination (ifosfamide/carboplatin [or cisplatin]/etoposide) has been studied in breast cancer, small cell and non-small cell lung cancer, testicular cancer, lymphoma, and other malignancies with promising results. Cisplatin 48-57 carboxylesterase 2 Homo sapiens 4-7 8677454-2 1996 The ICE combination (ifosfamide/carboplatin [or cisplatin]/etoposide) has been studied in breast cancer, small cell and non-small cell lung cancer, testicular cancer, lymphoma, and other malignancies with promising results. Etoposide 59-68 carboxylesterase 2 Homo sapiens 4-7 8626669-4 1996 Fas- and staurosporine-induced apoptosis as well as cleavage of D4-GDI were inhibited by the ICE inhibitor, YVAD-cmk. ammonium ferrous sulfate 0-3 carboxylesterase 2 Homo sapiens 93-96 8626669-4 1996 Fas- and staurosporine-induced apoptosis as well as cleavage of D4-GDI were inhibited by the ICE inhibitor, YVAD-cmk. Staurosporine 9-22 carboxylesterase 2 Homo sapiens 93-96 8626669-4 1996 Fas- and staurosporine-induced apoptosis as well as cleavage of D4-GDI were inhibited by the ICE inhibitor, YVAD-cmk. YVAD 108-112 carboxylesterase 2 Homo sapiens 93-96 8812100-0 1996 Crystallization of Ice in Aqueous Solutions of Glycerol and Dimethyl Sulfoxide. Glycerol 47-55 carboxylesterase 2 Homo sapiens 19-22 8812100-0 1996 Crystallization of Ice in Aqueous Solutions of Glycerol and Dimethyl Sulfoxide. Dimethyl Sulfoxide 60-78 carboxylesterase 2 Homo sapiens 19-22 8812100-2 1996 A Comparison of Mechanisms The crystallization of ice from aqueous solutions of glycerol and dimethyl sulfoxide (Me2SO) has been studied using differential scanning calorimetry. Glycerol 80-88 carboxylesterase 2 Homo sapiens 50-53 8812100-2 1996 A Comparison of Mechanisms The crystallization of ice from aqueous solutions of glycerol and dimethyl sulfoxide (Me2SO) has been studied using differential scanning calorimetry. Dimethyl Sulfoxide 93-111 carboxylesterase 2 Homo sapiens 50-53 8812100-2 1996 A Comparison of Mechanisms The crystallization of ice from aqueous solutions of glycerol and dimethyl sulfoxide (Me2SO) has been studied using differential scanning calorimetry. me2so 113-118 carboxylesterase 2 Homo sapiens 50-53 8812100-4 1996 These solutions (45 w/w% Me2SO (15.9 mol%) and 50 w/w% glycerol (16.4 mol%)) were shown to exhibit markedly different ice crystallization properties. me2so 25-30 carboxylesterase 2 Homo sapiens 118-121 8812100-4 1996 These solutions (45 w/w% Me2SO (15.9 mol%) and 50 w/w% glycerol (16.4 mol%)) were shown to exhibit markedly different ice crystallization properties. Glycerol 55-63 carboxylesterase 2 Homo sapiens 118-121 7602350-3 1995 ICE doses were ifosfamide 5 g/m2 by 24-hour continuous intravenous (CIV) infusion with mesna on day 1, carboplatin 300 mg/m2 intravenously (IV) on day 1, and etoposide 50 mg/m2 orally on days 1 to 21 every 4 weeks for up to six to eight cycles (schedule I). Ifosfamide 15-25 carboxylesterase 2 Homo sapiens 0-3 7610398-3 1995 Our results showed that the ICE regimen has activity against anthracycline-refractory metastatic breast cancer. Anthracyclines 61-74 carboxylesterase 2 Homo sapiens 28-31 7610398-4 1995 A dose-response relationship was not apparent with the mini-ICE regimen; however, among patients receiving maxi-ICE, a dose-response relationship was suggested in those patients responding to anthracycline-based chemotherapy. Anthracyclines 192-205 carboxylesterase 2 Homo sapiens 112-115 7610396-1 1995 The combination of ifosfamide (with mesna uroprotection), carboplatin, and etoposide (ICE) has demonstrated activity in a variety of cancers. Ifosfamide 19-29 carboxylesterase 2 Homo sapiens 86-89 7840041-0 1995 Smokable methamphetamine ("ice"): an old drug in a different form. Methamphetamine 9-24 carboxylesterase 2 Homo sapiens 27-30 7610396-1 1995 The combination of ifosfamide (with mesna uroprotection), carboplatin, and etoposide (ICE) has demonstrated activity in a variety of cancers. Etoposide 75-84 carboxylesterase 2 Homo sapiens 86-89 7610396-2 1995 Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ), a dipertene compound extracted from the Pacific yew Taxus brevifolia, appeared a good candidate for study as an addition to the ICE regimen (ICE-T) because of its broad antitumor activity, its unique mechanism of action, and its toxicity profile, which was not expected to impact the ICE regimen adversely. Paclitaxel 0-10 carboxylesterase 2 Homo sapiens 193-196 7610396-2 1995 Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ), a dipertene compound extracted from the Pacific yew Taxus brevifolia, appeared a good candidate for study as an addition to the ICE regimen (ICE-T) because of its broad antitumor activity, its unique mechanism of action, and its toxicity profile, which was not expected to impact the ICE regimen adversely. Paclitaxel 0-10 carboxylesterase 2 Homo sapiens 206-209 7610397-3 1995 Combining ifosfamide, carboplatin, and etoposide, among the most active single agents against SCLC, into the ICE regimen was a logical move that has resulted in improved response and survival rates. Ifosfamide 10-20 carboxylesterase 2 Homo sapiens 109-112 7610397-3 1995 Combining ifosfamide, carboplatin, and etoposide, among the most active single agents against SCLC, into the ICE regimen was a logical move that has resulted in improved response and survival rates. Etoposide 39-48 carboxylesterase 2 Homo sapiens 109-112 7610397-4 1995 In limited and extensive SCLC, respectively, ICE and ICE administered with vincristine (VICE) have achieved overall response rates of 79% to 94% and 77% to 100% and 2-year survival rates of 24% to 33% and 9% to 25%, respectively. Vincristine 75-86 carboxylesterase 2 Homo sapiens 45-48 7610397-4 1995 In limited and extensive SCLC, respectively, ICE and ICE administered with vincristine (VICE) have achieved overall response rates of 79% to 94% and 77% to 100% and 2-year survival rates of 24% to 33% and 9% to 25%, respectively. Vincristine 75-86 carboxylesterase 2 Homo sapiens 53-56 7610398-1 1995 We conducted a phase I/II trial to investigate the activity of ifosfamide/carboplatin/etoposide given over 2 or 3 days (mini-ICE) to patients with anthracycline-refractory or recurrent metastatic breast cancer. Ifosfamide 63-73 carboxylesterase 2 Homo sapiens 125-128 7610398-1 1995 We conducted a phase I/II trial to investigate the activity of ifosfamide/carboplatin/etoposide given over 2 or 3 days (mini-ICE) to patients with anthracycline-refractory or recurrent metastatic breast cancer. Carboplatin 74-85 carboxylesterase 2 Homo sapiens 125-128 7610398-1 1995 We conducted a phase I/II trial to investigate the activity of ifosfamide/carboplatin/etoposide given over 2 or 3 days (mini-ICE) to patients with anthracycline-refractory or recurrent metastatic breast cancer. Etoposide 86-95 carboxylesterase 2 Homo sapiens 125-128 7745195-4 1995 The purpose of this study was to determine if the application of ice to subcutaneous heparin injection sites decreases the incidence and size of haematoma formation and/or minimizes patient discomfort. Heparin 85-92 carboxylesterase 2 Homo sapiens 65-68 7840041-2 1995 The smokable form of methamphetamine hydrochloride, called "ice" on the street, is twice as toxic as amphetamine and has clinical effects similar to those of cocaine. Methamphetamine 21-50 carboxylesterase 2 Homo sapiens 60-63 7840041-2 1995 The smokable form of methamphetamine hydrochloride, called "ice" on the street, is twice as toxic as amphetamine and has clinical effects similar to those of cocaine. Amphetamine 25-36 carboxylesterase 2 Homo sapiens 60-63 7758997-4 1995 Experience gathered in recent years shows that idarubicin, cytosine arabinoside, and etoposide together might contribute to the modeling of an improved remission induction regimen: ICE. Idarubicin 47-57 carboxylesterase 2 Homo sapiens 181-184 7758997-4 1995 Experience gathered in recent years shows that idarubicin, cytosine arabinoside, and etoposide together might contribute to the modeling of an improved remission induction regimen: ICE. Cytarabine 59-79 carboxylesterase 2 Homo sapiens 181-184 7758997-4 1995 Experience gathered in recent years shows that idarubicin, cytosine arabinoside, and etoposide together might contribute to the modeling of an improved remission induction regimen: ICE. Etoposide 85-94 carboxylesterase 2 Homo sapiens 181-184 8835290-3 1995 The efficacy of LIP-TPT was examined with a novel in vivo bioassay called ICE for In vivo Complexes of Enzyme. lip-tpt 16-23 carboxylesterase 2 Homo sapiens 74-77 7517997-2 1994 Four different carbohydrate epitopes are expressed by sensory afferents on their 130 kDa surface proteins: all sensory afferents share a common carbohydrate epitope (CE0) that helps them to enter and project diffusely across the synaptic neuropil; a restricted expression of three other carbohydrate epitopes (CE1, CE2, and CE3) serves to distinguish three subsets of sensory afferents. Carbohydrates 15-27 carboxylesterase 2 Homo sapiens 315-318 7871269-18 1995 However new therapeutic associations, as the ICE regimen (IFM, Carboplatin, VP-16) delivered as single or tandem therapy, have to be studied, especially as early consolidation therapy for the treatment of limited small-cell lung carcinomas. Carboplatin 63-74 carboxylesterase 2 Homo sapiens 45-48 8048396-5 1994 Response rate to second-line ICE relates directly to prior response to first-line cisplatin-based chemotherapy: 12 patients (67%) responded to second-line ICE who responded to first-line cisplatin-based chemotherapy, while only 1 patient (14%) responded who progressed on first-line cisplatin-based chemotherapy. Cisplatin 82-91 carboxylesterase 2 Homo sapiens 29-32 8048396-5 1994 Response rate to second-line ICE relates directly to prior response to first-line cisplatin-based chemotherapy: 12 patients (67%) responded to second-line ICE who responded to first-line cisplatin-based chemotherapy, while only 1 patient (14%) responded who progressed on first-line cisplatin-based chemotherapy. Cisplatin 82-91 carboxylesterase 2 Homo sapiens 155-158 8048396-5 1994 Response rate to second-line ICE relates directly to prior response to first-line cisplatin-based chemotherapy: 12 patients (67%) responded to second-line ICE who responded to first-line cisplatin-based chemotherapy, while only 1 patient (14%) responded who progressed on first-line cisplatin-based chemotherapy. Cisplatin 187-196 carboxylesterase 2 Homo sapiens 29-32 8048396-5 1994 Response rate to second-line ICE relates directly to prior response to first-line cisplatin-based chemotherapy: 12 patients (67%) responded to second-line ICE who responded to first-line cisplatin-based chemotherapy, while only 1 patient (14%) responded who progressed on first-line cisplatin-based chemotherapy. Cisplatin 187-196 carboxylesterase 2 Homo sapiens 155-158 8048396-5 1994 Response rate to second-line ICE relates directly to prior response to first-line cisplatin-based chemotherapy: 12 patients (67%) responded to second-line ICE who responded to first-line cisplatin-based chemotherapy, while only 1 patient (14%) responded who progressed on first-line cisplatin-based chemotherapy. Cisplatin 187-196 carboxylesterase 2 Homo sapiens 29-32 8048396-5 1994 Response rate to second-line ICE relates directly to prior response to first-line cisplatin-based chemotherapy: 12 patients (67%) responded to second-line ICE who responded to first-line cisplatin-based chemotherapy, while only 1 patient (14%) responded who progressed on first-line cisplatin-based chemotherapy. Cisplatin 187-196 carboxylesterase 2 Homo sapiens 155-158 7517997-2 1994 Four different carbohydrate epitopes are expressed by sensory afferents on their 130 kDa surface proteins: all sensory afferents share a common carbohydrate epitope (CE0) that helps them to enter and project diffusely across the synaptic neuropil; a restricted expression of three other carbohydrate epitopes (CE1, CE2, and CE3) serves to distinguish three subsets of sensory afferents. Carbohydrates 144-156 carboxylesterase 2 Homo sapiens 315-318 8254335-1 1993 A series of new vitamin B6 triethanolamine rare earth (III) complexes Re(PN)3(TEA)(NO3)2Cl (PN = pyridoxol; TEA = triethanolamine; Re = La1, Ce2, Pr3, Nd4, Sm5, Tb6, Dy7, Ho8, Er9, Y10), were synthesized and characterized by elemental analysis, molar conductance, TGA-DTA, UV, IR, and 1H NMR spectroscopic techniques. vitamin b6 triethanolamine 16-42 carboxylesterase 2 Homo sapiens 141-144 8133538-13 1994 CONCLUSION: ICE chemotherapy, with the carboplatin dose based on a target AUC of 10 mg.min/mL, is tolerable and has significant activity in a variety of rare malignancies, including extragonadal germ cell tumors. Carboplatin 39-50 carboxylesterase 2 Homo sapiens 12-15 8445431-13 1993 The clear relationship between hematologic toxicity and carboplatin systemic exposure supports the use of targeted dosing in further trials of ICE chemotherapy. Carboplatin 56-67 carboxylesterase 2 Homo sapiens 143-146 2346514-1 1990 The sterically acceptable structures of cyclo(2 delta----5)[D-Orn2, Pro5]- and cyclo(2 delta----5)[D-Orn2, Leu5]enkephalin (CE1 and CE2) consistent with NMR data including coupling constants, temperature dependencies of chemical shifts for amide protons and NOE values have been found by use of energy calculations in terms of rigid valence geometry and refined by the MM2 procedure. emodepside 79-84 carboxylesterase 2 Homo sapiens 132-135 2028917-5 1991 To the author"s knowledge, this paper is the first to quantify and compare a Freon-based system with a circulating ice water system. Water 119-124 carboxylesterase 2 Homo sapiens 115-118 33818816-13 2021 CONCLUSION: Results indicate that NAT2 and CES2 are involved in rociletinib metabolism, and polymorphic NAT2 could alter drug exposure in patients. rociletinib 64-75 carboxylesterase 2 Homo sapiens 43-47 33818816-4 2021 METHODS: Rociletinib and metabolites were incubated with carboxylesterase (CES)1b, CES1c, CES2, NAT1, NAT2, arylacetamide deacetylase (AADAC), inhibitors, pooled human liver microsomes (HLMs) and cytosols (HLCs). rociletinib 9-20 carboxylesterase 2 Homo sapiens 90-94 33808099-0 2021 A Tale of Ice and Fire: The Dual Role for 17beta-Estradiol in Balancing DNA Damage and Genome Integrity. Estradiol 42-58 carboxylesterase 2 Homo sapiens 10-13 33761503-11 2021 He received 3 cycles of chemotherapy with ICE regimen (ifosfamide, carboplatin, and etoposide). Ifosfamide 55-65 carboxylesterase 2 Homo sapiens 42-45 34694804-5 2021 Among the constructed molecule candidates, NIC-4 inhibited both isoforms of hCE1 and hCE2, with IC50 values of 4.56 and 4.11 muM. nic-4 43-48 carboxylesterase 2 Homo sapiens 85-89 34949363-4 2022 In this study, Fe2(SO4)3/TiO2 and Ce2(SO4)3/TiO2 catalysts were prepared using the corresponding metal sulfate salt as the precursor. titanium dioxide 44-48 carboxylesterase 2 Homo sapiens 34-43 34949363-4 2022 In this study, Fe2(SO4)3/TiO2 and Ce2(SO4)3/TiO2 catalysts were prepared using the corresponding metal sulfate salt as the precursor. metal sulfate salt 97-115 carboxylesterase 2 Homo sapiens 34-43 34949363-7 2022 It was demonstrated that less surface sulfate species formed on Fe2(SO4)3/TiO2 and Ce2(SO4)3/TiO2. Sulfates 38-45 carboxylesterase 2 Homo sapiens 83-92 34949363-7 2022 It was demonstrated that less surface sulfate species formed on Fe2(SO4)3/TiO2 and Ce2(SO4)3/TiO2. titanium dioxide 93-97 carboxylesterase 2 Homo sapiens 83-92 34949363-8 2022 However, the presence of NO and O2 could assist the decomposition of NH4HSO4 over Fe2(SO4)3/TiO2 at a lower temperature, endowing Fe2(SO4)3/TiO2 with better low-temperature SO2 tolerance than Ce2(SO4)3/TiO2. ammonium bisulfate 69-76 carboxylesterase 2 Homo sapiens 192-201 34949363-8 2022 However, the presence of NO and O2 could assist the decomposition of NH4HSO4 over Fe2(SO4)3/TiO2 at a lower temperature, endowing Fe2(SO4)3/TiO2 with better low-temperature SO2 tolerance than Ce2(SO4)3/TiO2. fe2(so4)3 82-91 carboxylesterase 2 Homo sapiens 192-201 34949363-8 2022 However, the presence of NO and O2 could assist the decomposition of NH4HSO4 over Fe2(SO4)3/TiO2 at a lower temperature, endowing Fe2(SO4)3/TiO2 with better low-temperature SO2 tolerance than Ce2(SO4)3/TiO2. titanium dioxide 92-96 carboxylesterase 2 Homo sapiens 192-201 34949363-8 2022 However, the presence of NO and O2 could assist the decomposition of NH4HSO4 over Fe2(SO4)3/TiO2 at a lower temperature, endowing Fe2(SO4)3/TiO2 with better low-temperature SO2 tolerance than Ce2(SO4)3/TiO2. Sulfur Dioxide 173-176 carboxylesterase 2 Homo sapiens 192-201 34949363-8 2022 However, the presence of NO and O2 could assist the decomposition of NH4HSO4 over Fe2(SO4)3/TiO2 at a lower temperature, endowing Fe2(SO4)3/TiO2 with better low-temperature SO2 tolerance than Ce2(SO4)3/TiO2. titanium dioxide 202-206 carboxylesterase 2 Homo sapiens 192-201 34956108-9 2021 Previously reported important prophages, such as phiHKU16.vir, phiHKU488.vir, Phi5005.1, Phi5005.2, and Phi5005.3 encoding streptococcal toxin, and integrative conjugative elements (ICEs) such as ICE-emm12 and ICE-HKU397 encoding macrolide and tetracycline resistance were found present amongst emm1 or emm12 clones from Shenzhen, China. hku397 214-220 carboxylesterase 2 Homo sapiens 210-213 34830838-5 2021 For the majority of 26 LA-NSCLC patients, iCE achieved improved heart and esophagus sparing compared to the manually created clinical plans, with significant reductions in the median heart Dmean (8.1 vs. 9.0 Gy, p = 0.02) and esophagus Dmean (18.5 vs. 20.3 Gy, p = 0.02), and reductions of up to 6.7 Gy and 5.8 Gy for individual patients. DMEAN 189-194 carboxylesterase 2 Homo sapiens 42-45 34830838-5 2021 For the majority of 26 LA-NSCLC patients, iCE achieved improved heart and esophagus sparing compared to the manually created clinical plans, with significant reductions in the median heart Dmean (8.1 vs. 9.0 Gy, p = 0.02) and esophagus Dmean (18.5 vs. 20.3 Gy, p = 0.02), and reductions of up to 6.7 Gy and 5.8 Gy for individual patients. DMEAN 236-241 carboxylesterase 2 Homo sapiens 42-45 33761503-11 2021 He received 3 cycles of chemotherapy with ICE regimen (ifosfamide, carboplatin, and etoposide). Carboplatin 67-78 carboxylesterase 2 Homo sapiens 42-45 33761503-11 2021 He received 3 cycles of chemotherapy with ICE regimen (ifosfamide, carboplatin, and etoposide). Etoposide 84-93 carboxylesterase 2 Homo sapiens 42-45 34761870-3 2022 In addition, in silico predictions indicated that carfentanil, 4F-MDMB-BINACA, 5F-MDMB-PICA, MDMB-4en-PINACA and mitragynine might also undergo microbial hydrolysis, in a similar fashion of cocaine degradation by cocaine esterase. carfentanil 50-61 carboxylesterase 2 Homo sapiens 213-229 34761870-3 2022 In addition, in silico predictions indicated that carfentanil, 4F-MDMB-BINACA, 5F-MDMB-PICA, MDMB-4en-PINACA and mitragynine might also undergo microbial hydrolysis, in a similar fashion of cocaine degradation by cocaine esterase. UNII-ZH38UTM145 63-77 carboxylesterase 2 Homo sapiens 213-229 34761870-3 2022 In addition, in silico predictions indicated that carfentanil, 4F-MDMB-BINACA, 5F-MDMB-PICA, MDMB-4en-PINACA and mitragynine might also undergo microbial hydrolysis, in a similar fashion of cocaine degradation by cocaine esterase. 5F-Mdmb-pica 79-91 carboxylesterase 2 Homo sapiens 213-229 34761870-3 2022 In addition, in silico predictions indicated that carfentanil, 4F-MDMB-BINACA, 5F-MDMB-PICA, MDMB-4en-PINACA and mitragynine might also undergo microbial hydrolysis, in a similar fashion of cocaine degradation by cocaine esterase. UNII-K2DZN2TDD6 93-108 carboxylesterase 2 Homo sapiens 213-229 34761870-3 2022 In addition, in silico predictions indicated that carfentanil, 4F-MDMB-BINACA, 5F-MDMB-PICA, MDMB-4en-PINACA and mitragynine might also undergo microbial hydrolysis, in a similar fashion of cocaine degradation by cocaine esterase. mitragynine 113-124 carboxylesterase 2 Homo sapiens 213-229 34761870-3 2022 In addition, in silico predictions indicated that carfentanil, 4F-MDMB-BINACA, 5F-MDMB-PICA, MDMB-4en-PINACA and mitragynine might also undergo microbial hydrolysis, in a similar fashion of cocaine degradation by cocaine esterase. Cocaine 190-197 carboxylesterase 2 Homo sapiens 213-229 34351032-3 2021 Here, we identified the bacterial cocaine esterase (CocE) as a BZE-metabolizing enzyme (BZEase), which can degrade BZE into biological inactive metabolites (ecgonine and benzoic acid). ecgonine 157-165 carboxylesterase 2 Homo sapiens 34-50 34536357-4 2021 Carboxylesterase 2 (CES2) is a serine esterase responsible for the hydrolysis of drugs and endogenous substrates, such as triglycerides and diacylglycerides. Serine 31-37 carboxylesterase 2 Homo sapiens 0-18 34536357-4 2021 Carboxylesterase 2 (CES2) is a serine esterase responsible for the hydrolysis of drugs and endogenous substrates, such as triglycerides and diacylglycerides. Serine 31-37 carboxylesterase 2 Homo sapiens 20-24 34536357-4 2021 Carboxylesterase 2 (CES2) is a serine esterase responsible for the hydrolysis of drugs and endogenous substrates, such as triglycerides and diacylglycerides. Triglycerides 122-135 carboxylesterase 2 Homo sapiens 0-18 34536357-4 2021 Carboxylesterase 2 (CES2) is a serine esterase responsible for the hydrolysis of drugs and endogenous substrates, such as triglycerides and diacylglycerides. Triglycerides 122-135 carboxylesterase 2 Homo sapiens 20-24 34536357-4 2021 Carboxylesterase 2 (CES2) is a serine esterase responsible for the hydrolysis of drugs and endogenous substrates, such as triglycerides and diacylglycerides. diacylglycerides 140-156 carboxylesterase 2 Homo sapiens 0-18 34536357-4 2021 Carboxylesterase 2 (CES2) is a serine esterase responsible for the hydrolysis of drugs and endogenous substrates, such as triglycerides and diacylglycerides. diacylglycerides 140-156 carboxylesterase 2 Homo sapiens 20-24 34536357-6 2021 CES2 mRNA level was significantly increased by double knockdown of METTL3 and METTL14 but was decreased by knockdown of FTO or ALKBH5 in HepaRG and HepG2 cells, leading to changes in its protein level and hydrolase activity for 7-ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycamptothecin (CPT-11), suggesting that m6A modification negatively regulates CES2 expression. Irinotecan 228-293 carboxylesterase 2 Homo sapiens 0-4 34536357-6 2021 CES2 mRNA level was significantly increased by double knockdown of METTL3 and METTL14 but was decreased by knockdown of FTO or ALKBH5 in HepaRG and HepG2 cells, leading to changes in its protein level and hydrolase activity for 7-ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycamptothecin (CPT-11), suggesting that m6A modification negatively regulates CES2 expression. Irinotecan 295-301 carboxylesterase 2 Homo sapiens 0-4 34536357-6 2021 CES2 mRNA level was significantly increased by double knockdown of METTL3 and METTL14 but was decreased by knockdown of FTO or ALKBH5 in HepaRG and HepG2 cells, leading to changes in its protein level and hydrolase activity for 7-ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycamptothecin (CPT-11), suggesting that m6A modification negatively regulates CES2 expression. Irinotecan 295-301 carboxylesterase 2 Homo sapiens 358-362 34351032-3 2021 Here, we identified the bacterial cocaine esterase (CocE) as a BZE-metabolizing enzyme (BZEase), which can degrade BZE into biological inactive metabolites (ecgonine and benzoic acid). ecgonine 157-165 carboxylesterase 2 Homo sapiens 52-56 34351032-3 2021 Here, we identified the bacterial cocaine esterase (CocE) as a BZE-metabolizing enzyme (BZEase), which can degrade BZE into biological inactive metabolites (ecgonine and benzoic acid). Benzoic Acid 170-182 carboxylesterase 2 Homo sapiens 34-50 34351032-3 2021 Here, we identified the bacterial cocaine esterase (CocE) as a BZE-metabolizing enzyme (BZEase), which can degrade BZE into biological inactive metabolites (ecgonine and benzoic acid). Benzoic Acid 170-182 carboxylesterase 2 Homo sapiens 52-56 34329577-2 2021 The aim of this study is to establish the safety and activity of dose-dense brentuximab vedotin combined with ifosfamide, carboplatin, and etoposide (BV-ICE) chemotherapy in second-line treatment of classical Hodgkin lymphoma. SGN-30 monoclonal antibody 76-87 carboxylesterase 2 Homo sapiens 153-156 34236118-5 2021 This review describes and critically evaluates fundamental principles, fabrication and characterization approaches, and biomedical applications of ice templating in polymer-based biomaterials. Polymers 165-172 carboxylesterase 2 Homo sapiens 147-150 34171773-3 2021 AADAC, CES1, and CES2 activities in human liver microsomes were measured using phenacetin, fenofibrate, and procaine as specific substrates, respectively. Phenacetin 79-89 carboxylesterase 2 Homo sapiens 17-21 34171773-7 2021 ECg and EGCg also strongly inhibited AADAC-mediated rifampicin hydrolase activity in human liver microsomes with IC50 values of 2.2 +- 1.4 and 1.7 +- 0.4 muM, respectively, whereas it weakly inhibited p-nitrophenyl acetate hydrolase activity, which is catalyzed by AADAC, CES1, and CES2. epicatechin gallate 0-3 carboxylesterase 2 Homo sapiens 282-286 34171773-7 2021 ECg and EGCg also strongly inhibited AADAC-mediated rifampicin hydrolase activity in human liver microsomes with IC50 values of 2.2 +- 1.4 and 1.7 +- 0.4 muM, respectively, whereas it weakly inhibited p-nitrophenyl acetate hydrolase activity, which is catalyzed by AADAC, CES1, and CES2. epigallocatechin gallate 8-12 carboxylesterase 2 Homo sapiens 282-286 34329577-2 2021 The aim of this study is to establish the safety and activity of dose-dense brentuximab vedotin combined with ifosfamide, carboplatin, and etoposide (BV-ICE) chemotherapy in second-line treatment of classical Hodgkin lymphoma. vedotin 88-95 carboxylesterase 2 Homo sapiens 153-156 34329577-2 2021 The aim of this study is to establish the safety and activity of dose-dense brentuximab vedotin combined with ifosfamide, carboplatin, and etoposide (BV-ICE) chemotherapy in second-line treatment of classical Hodgkin lymphoma. Ifosfamide 110-120 carboxylesterase 2 Homo sapiens 153-156 34329577-2 2021 The aim of this study is to establish the safety and activity of dose-dense brentuximab vedotin combined with ifosfamide, carboplatin, and etoposide (BV-ICE) chemotherapy in second-line treatment of classical Hodgkin lymphoma. Etoposide 139-148 carboxylesterase 2 Homo sapiens 153-156 34201622-2 2021 In this regard, the effect of a variety and concentration of grape pomace extracts (Feteasca Neagra or Merlot) incorporated within ice-templated 3D xanthan-based composites was evaluated by considering their water content, surface and texture properties, radical scavenging and microbiological activities. xanthan gum 148-155 carboxylesterase 2 Homo sapiens 131-134 34310116-3 2021 Here, a synergistic process between reduction and stabilization was proposed by innovatively using elemental sulfur (S) as reductant for converting insoluble CeO2 into soluble Ce2(SO4)3 and transforming Fe and Mn oxides into inert FeFe2O4 and MnFe2O4 spinel minerals. Sulfur 109-115 carboxylesterase 2 Homo sapiens 176-185 34310116-3 2021 Here, a synergistic process between reduction and stabilization was proposed by innovatively using elemental sulfur (S) as reductant for converting insoluble CeO2 into soluble Ce2(SO4)3 and transforming Fe and Mn oxides into inert FeFe2O4 and MnFe2O4 spinel minerals. ceric oxide 158-162 carboxylesterase 2 Homo sapiens 176-185 34340419-0 2021 Development of a deuterium-ice extruder for inertial confinement fusion experiments on the Z Facility. Deuterium 17-26 carboxylesterase 2 Homo sapiens 27-30 34340419-1 2021 A deuterium-ice extruder has been developed for inertial confinement fusion experiments on the Sandia National Laboratories Z Facility. Deuterium 2-11 carboxylesterase 2 Homo sapiens 12-15 34340419-8 2021 Deuterium-ice fibers can persist in high vacuum for more than 10 min before breaking free from the nozzle. Deuterium 0-9 carboxylesterase 2 Homo sapiens 10-13 34084136-0 2021 Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2. biflavones 38-48 carboxylesterase 2 Homo sapiens 123-141 34084136-1 2021 Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the small intestine, has been validated as a key therapeutic target to ameliorate the intestinal toxicity caused by irinotecan. Irinotecan 200-210 carboxylesterase 2 Homo sapiens 6-24 35045706-0 2022 Inhibition of Ice Recrystallization by Nanotube-Forming Cyclic Peptides. Peptides, Cyclic 56-71 carboxylesterase 2 Homo sapiens 14-17 35275642-1 2022 Using time-resolved wide-angle X-ray scattering, we investigated the early stages (10 mus-1 ms) of crystallization of supercooled water, obtained by the ultrafast heating of high- and low-density amorphous ice (HDA and LDA) up to a temperature T = 205 K +- 10 K. We have determined that the crystallizing phase is stacking disordered ice (Isd), with a maximum cubicity of chi = 0.6, in agreement with predictions from molecular dynamics simulations at similar temperatures. Water 130-135 carboxylesterase 2 Homo sapiens 206-209 35275642-1 2022 Using time-resolved wide-angle X-ray scattering, we investigated the early stages (10 mus-1 ms) of crystallization of supercooled water, obtained by the ultrafast heating of high- and low-density amorphous ice (HDA and LDA) up to a temperature T = 205 K +- 10 K. We have determined that the crystallizing phase is stacking disordered ice (Isd), with a maximum cubicity of chi = 0.6, in agreement with predictions from molecular dynamics simulations at similar temperatures. Water 130-135 carboxylesterase 2 Homo sapiens 334-337 35045706-3 2022 Here, we exploit the predictable assembly of cyclic peptides into nanotubes as a starting point to prepare large, rigid ice-binders bearing an ice-binding site that is found in hyperactive ice-binding proteins in insects. Peptides 52-60 carboxylesterase 2 Homo sapiens 120-123 35045706-3 2022 Here, we exploit the predictable assembly of cyclic peptides into nanotubes as a starting point to prepare large, rigid ice-binders bearing an ice-binding site that is found in hyperactive ice-binding proteins in insects. Peptides 52-60 carboxylesterase 2 Homo sapiens 143-146 35045706-3 2022 Here, we exploit the predictable assembly of cyclic peptides into nanotubes as a starting point to prepare large, rigid ice-binders bearing an ice-binding site that is found in hyperactive ice-binding proteins in insects. Peptides 52-60 carboxylesterase 2 Homo sapiens 189-192 35308687-14 2022 Two in three people reported current or past drug use, with tetrahydrocannabinol (THC) being the most commonly used drug, followed by sedatives, opioids/pain relief medications, amphetamines, or methamphetamine (ICE), and others (e.g., alcohol). Methamphetamine 195-210 carboxylesterase 2 Homo sapiens 212-215 35114918-0 2022 Substrate-dependent inhibition of hypericin on human carboxylesterase 2: implications for herb-drug combination. hypericin 34-43 carboxylesterase 2 Homo sapiens 53-71 35114918-2 2022 Previous studies have shown that hypericin can strongly inhibit human cytochrome P450 (CYP) enzyme activities; however, its potential interactions that inhibit human carboxylesterases 2 (hCE2) were unclear. hypericin 33-42 carboxylesterase 2 Homo sapiens 187-191 35114918-3 2022 PURPOSE: The study aimed to investigate the inhibition of hypericin on hCE2. hypericin 58-67 carboxylesterase 2 Homo sapiens 71-75 35114918-4 2022 METHODS: The inhibition of hypericin on hCE2 was studied by using N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-phenalen-6-yl)-2-chloroacetamide (NCEN). hypericin 27-36 carboxylesterase 2 Homo sapiens 40-44 35114918-4 2022 METHODS: The inhibition of hypericin on hCE2 was studied by using N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-phenalen-6-yl)-2-chloroacetamide (NCEN). N-(2-butyl-1,3-dioxo-2,3-dihydro-1h-phenalen-6-yl)-2-chloroacetamide 66-134 carboxylesterase 2 Homo sapiens 40-44 35114918-4 2022 METHODS: The inhibition of hypericin on hCE2 was studied by using N-(2-butyl-1,3-dioxo-2,3-dihydro-1H-phenalen-6-yl)-2-chloroacetamide (NCEN). ncen 136-140 carboxylesterase 2 Homo sapiens 40-44 35114918-5 2022 The type of inhibition of hypericin on hCE2 and the corresponding inhibition constant (Ki) value were determined. hypericin 26-35 carboxylesterase 2 Homo sapiens 39-43 35114918-6 2022 The inhibition of hypericin on hCE2 in living cells was discussed. hypericin 18-27 carboxylesterase 2 Homo sapiens 31-35 35114918-7 2022 The herb-drug interactions (HDI) risk of hypericin and hCE2 in vivo was predicted by estimating the drug concentration-time curve (AUC) ratio of hypericin and hypericin free. hypericin 145-154 carboxylesterase 2 Homo sapiens 55-59 35114918-7 2022 The herb-drug interactions (HDI) risk of hypericin and hCE2 in vivo was predicted by estimating the drug concentration-time curve (AUC) ratio of hypericin and hypericin free. hypericin 159-168 carboxylesterase 2 Homo sapiens 55-59 35114918-8 2022 To understand the inhibition mechanism of hypericin on the activity of hCE2 in-depth, molecular docking was performed. hypericin 42-51 carboxylesterase 2 Homo sapiens 71-75 35114918-12 2022 Moreover, hypericin distinctly suppressed hCE2 activity in living cells. hypericin 10-19 carboxylesterase 2 Homo sapiens 42-46 35114918-13 2022 In addition, the AUC of hCE2 metabolic drugs with metabolic sites similar to NCEN was estimated to increase by up to 5%, in the presence of hypericin. hypericin 140-149 carboxylesterase 2 Homo sapiens 24-28 35114918-15 2022 Further, molecular simulations indicated that hypericin could strongly interact with ASP98, PHE307, and ARG355 to form four hydrogen bonds within hCE2. hypericin 46-55 carboxylesterase 2 Homo sapiens 146-150 35114918-15 2022 Further, molecular simulations indicated that hypericin could strongly interact with ASP98, PHE307, and ARG355 to form four hydrogen bonds within hCE2. Hydrogen 124-132 carboxylesterase 2 Homo sapiens 146-150 35114918-16 2022 CONCLUSION: These findings are of considerable clinical significance to the combination of hypericin-containing herbs and drugs metabolized by hCE2. hypericin 91-100 carboxylesterase 2 Homo sapiens 143-147