PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33445878-9	2021	The PS-NPBs regulate the expression of olig2, foxg1a, fzd8b, six3a, rx1, lhx2b, nkx2.1a, and sfrp5 to alter nervous system development, retinal development, and stem cell differentiation.	4-nitrophenethyl bromide	6-11	NK2 homeobox 4b	Danio rerio	80-87
33182161-5	2021	Following a 5 d exposure to PFTrDA, zebrafish larvae showed upregulation of the genes responsible for thyroid hormone synthesis (tshbeta, nkx2.1, nis, tpo, mct8) and (de)activation (dio1, dio2).	pftrda	28-34	NK2 homeobox 4b	Danio rerio	138-144
33027873-5	2020	Tralopyril decreased the thyroid hormone concentrations in embryos and changed the transcriptions of the related genes (TRHR, TSHbeta, TSHR, Nkx2.1, Dio1, TRalpha, TRbeta, TTR and UGT1ab).	4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile	0-10	NK2 homeobox 4b	Danio rerio	141-147
24658602-9	2014	Exposure to MEHP also significantly induced transcription of genes involved in thyroid development (Nkx2.1 and Pax8) and thyroid hormone synthesis (TSHbeta, NIS and TG).	mono-(2-ethylhexyl)phthalate	12-16	NK2 homeobox 4b	Danio rerio	100-106
32434089-7	2020	Transcription levels of genes in the early stage embryos (gh, crx, neuroD and nkx2.4b) decreased significantly after FLU treatments.	fluxapyroxad	117-120	NK2 homeobox 4b	Danio rerio	78-85
32980012-5	2020	The expression levels of early embryogenesis-related genes (gh, crx, sox2 and neuroD) were downregulated after BIX exposure, except for nkx2.4b, which was upregulated.	2-(3,4-dihydroxyphenyl)-2-oxoethyl thiocyanate	111-114	NK2 homeobox 4b	Danio rerio	136-143
22307006-6	2012	Genes involved in thyroid development (Pax8 and Nkx2.1) and synthesis (sodium/iodide symporter, NIS, thyroglobulin, TG) were also transcriptionally up-regulated.	Sodium	71-77	NK2 homeobox 4b	Danio rerio	48-54
24177579-4	2013	Compared with the exposure to BDE-47 alone, the exposure to a combination of BDE-47 (10 mug/L) and PER (3.5 mg/L) significantly up-regulated the expression of genes involved in TH synthesis (NIS and Nkx2.1a) and significantly down-regulated the expression of genes related to the regulation of the HPT axis (CRH and TSHbeta).	2,2',4,4'-tetrabromodiphenyl ether	77-83	NK2 homeobox 4b	Danio rerio	199-206
22307006-6	2012	Genes involved in thyroid development (Pax8 and Nkx2.1) and synthesis (sodium/iodide symporter, NIS, thyroglobulin, TG) were also transcriptionally up-regulated.	Iodides	78-84	NK2 homeobox 4b	Danio rerio	48-54
34801571-6	2022	Furthermore, the transcription levels of marker genes associated with early embryonic development (myoD, nkx2.4b, myh6, and gh) were disrupted after BEN treatment.	benfuracarb	149-152	NK2 homeobox 4b	Danio rerio	105-112