PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
23751361-0	2013	Reynosin protects against neuronal toxicity in dopamine-induced SH-SY5Y cells and 6-hydroxydopamine-lesioned rats as models of Parkinson"s disease: Reciprocal up-regulation of E6-AP and down-regulation of alpha-synuclein.	reynosin	0-8	ubiquitin protein ligase E3A	Homo sapiens	176-181
24244715-5	2013	Moreover, triptolide enhances p53 expression by increasing its stability via down-regulation of E6 and E6AP.	triptolide	10-20	ubiquitin protein ligase E3A	Homo sapiens	103-107
23751361-6	2013	These results suggest that the protective effect of reynosin against dopamine-induced neuronal cell death may be due to the reciprocal up-regulation of E6-associated protein and down-regulation of alpha-synuclein protein expression.	reynosin	52-60	ubiquitin protein ligase E3A	Homo sapiens	152-173
23751361-6	2013	These results suggest that the protective effect of reynosin against dopamine-induced neuronal cell death may be due to the reciprocal up-regulation of E6-associated protein and down-regulation of alpha-synuclein protein expression.	Dopamine	69-77	ubiquitin protein ligase E3A	Homo sapiens	152-173
24164050-8	2014	Some azoics and disulfides were selected depending on their affinity towards E6 zinc finger and thereby preventing E6-E6AP complex formation.	azoics	5-11	ubiquitin protein ligase E3A	Homo sapiens	118-122
24164050-8	2014	Some azoics and disulfides were selected depending on their affinity towards E6 zinc finger and thereby preventing E6-E6AP complex formation.	Disulfides	16-26	ubiquitin protein ligase E3A	Homo sapiens	118-122
24164050-9	2014	Combinatorial nontoxic derivatives of these azoics and disulfides were docked and validated against the oncoprotein to inhibit E6-E6AP interaction.	azoics	44-50	ubiquitin protein ligase E3A	Homo sapiens	130-134
24164050-9	2014	Combinatorial nontoxic derivatives of these azoics and disulfides were docked and validated against the oncoprotein to inhibit E6-E6AP interaction.	Disulfides	55-65	ubiquitin protein ligase E3A	Homo sapiens	130-134
24376816-10	2013	Docking analyses suggest that these compounds bind in a hydrophobic pocket at the interface between E6 and E6AP and mimic the leucines in the conserved alpha-helical motif of E6AP.	Leucine	126-134	ubiquitin protein ligase E3A	Homo sapiens	107-111
24376816-10	2013	Docking analyses suggest that these compounds bind in a hydrophobic pocket at the interface between E6 and E6AP and mimic the leucines in the conserved alpha-helical motif of E6AP.	Leucine	126-134	ubiquitin protein ligase E3A	Homo sapiens	175-179
23751361-0	2013	Reynosin protects against neuronal toxicity in dopamine-induced SH-SY5Y cells and 6-hydroxydopamine-lesioned rats as models of Parkinson"s disease: Reciprocal up-regulation of E6-AP and down-regulation of alpha-synuclein.	Dopamine	47-55	ubiquitin protein ligase E3A	Homo sapiens	176-181
22401851-6	2012	It has recently yielded an N-methylated macrocyclic peptide having high affinity (Kd=0.60 nM) for its target protein, E6AP.	Nitrogen	27-28	ubiquitin protein ligase E3A	Homo sapiens	118-122
22482589-1	2012	Solvent effect on protein conformation and folding mechanism of E6-associated protein (E6ap) peptide are investigated using a recently developed charge update scheme termed as adaptive hydrogen bond-specific charge (AHBC).	Hydrogen	185-193	ubiquitin protein ligase E3A	Homo sapiens	64-85
22482589-1	2012	Solvent effect on protein conformation and folding mechanism of E6-associated protein (E6ap) peptide are investigated using a recently developed charge update scheme termed as adaptive hydrogen bond-specific charge (AHBC).	Hydrogen	185-193	ubiquitin protein ligase E3A	Homo sapiens	87-91
22986523-5	2013	Cells lacking E6AP expression have reduced capacity to accumulate ROS, and oxidative DNA damage, in response to 20% cell culture oxygen levels, treatment with hydrogen peroxide and expression of oncogenic RAS.	Reactive Oxygen Species	66-69	ubiquitin protein ligase E3A	Homo sapiens	14-18
22986523-5	2013	Cells lacking E6AP expression have reduced capacity to accumulate ROS, and oxidative DNA damage, in response to 20% cell culture oxygen levels, treatment with hydrogen peroxide and expression of oncogenic RAS.	Oxygen	129-135	ubiquitin protein ligase E3A	Homo sapiens	14-18
22986523-5	2013	Cells lacking E6AP expression have reduced capacity to accumulate ROS, and oxidative DNA damage, in response to 20% cell culture oxygen levels, treatment with hydrogen peroxide and expression of oncogenic RAS.	Hydrogen Peroxide	159-176	ubiquitin protein ligase E3A	Homo sapiens	14-18
22986523-8	2013	In a xenograft model, downregulation of E6AP renders transplanted tumours refractory to growth-suppressive effects of hydrogen peroxide.	Hydrogen Peroxide	118-135	ubiquitin protein ligase E3A	Homo sapiens	40-44
22986523-9	2013	Our results provide the first demonstration that E6AP is an important regulator of ROS-mediated cellular senescence and cell death.	Reactive Oxygen Species	83-86	ubiquitin protein ligase E3A	Homo sapiens	49-53
23581475-7	2013	We mapped the phosphorylation site to tyrosine 636 within the HECT catalytic domain of E6AP, and using substitution mutants, we showed that this residue dictates the E3 ligase activity of E6AP, in a substrate-specific manner.	Tyrosine	38-46	ubiquitin protein ligase E3A	Homo sapiens	87-91
23581475-7	2013	We mapped the phosphorylation site to tyrosine 636 within the HECT catalytic domain of E6AP, and using substitution mutants, we showed that this residue dictates the E3 ligase activity of E6AP, in a substrate-specific manner.	Tyrosine	38-46	ubiquitin protein ligase E3A	Homo sapiens	188-192
23581475-8	2013	On the basis of the crystal structure of the HECT domain of E6AP, we propose a model in which tyrosine 636 plays a regulatory role in the oligomerization of E6AP, which is a process implicated in its E3 ubiquitin ligase activity.	Tyrosine	94-102	ubiquitin protein ligase E3A	Homo sapiens	60-64
23581475-8	2013	On the basis of the crystal structure of the HECT domain of E6AP, we propose a model in which tyrosine 636 plays a regulatory role in the oligomerization of E6AP, which is a process implicated in its E3 ubiquitin ligase activity.	Tyrosine	94-102	ubiquitin protein ligase E3A	Homo sapiens	157-161
23598402-3	2013	Wild-type E6AP promotes ubiquitin dependent proteasome degradation of C/EBPalpha, while catalytically inactive E6-associated protein having cysteine replaced with alanine at amino-acid position 843 (E6AP-C843A) rather stabilizes it.	Cysteine	140-148	ubiquitin protein ligase E3A	Homo sapiens	111-132
23598402-7	2013	We show that overexpression of catalytically inactive E6AP-C843A in C/EBPalpha inducible K562- p42C/EBPalpha-estrogen receptor (ER) cells inhibits beta-estradiol (E2)-induced C/EBPalpha degradation leading to enhanced granulocytic differentiation.	Estradiol	147-161	ubiquitin protein ligase E3A	Homo sapiens	54-58
23143301-7	2012	These findings demonstrate the complex effects of UBE3A loss on dopamine signaling in subcortical motor pathways that may inform ongoing clinical trials of L-DOPA therapy in patients with AS.	Dopamine	64-72	ubiquitin protein ligase E3A	Homo sapiens	50-55
23143301-7	2012	These findings demonstrate the complex effects of UBE3A loss on dopamine signaling in subcortical motor pathways that may inform ongoing clinical trials of L-DOPA therapy in patients with AS.	Levodopa	156-162	ubiquitin protein ligase E3A	Homo sapiens	50-55
22589186-0	2012	Proteomic identification of E6AP as a molecular target of tamoxifen in MCF7 cells.	Tamoxifen	58-67	ubiquitin protein ligase E3A	Homo sapiens	28-32
22589186-7	2012	Taken together, our data suggest that, Tam-targeted E6AP inhibition is in fact required for Tam-mediated antibreast cancer actions.	Tamoxifen	39-42	ubiquitin protein ligase E3A	Homo sapiens	52-56
22589186-7	2012	Taken together, our data suggest that, Tam-targeted E6AP inhibition is in fact required for Tam-mediated antibreast cancer actions.	Tamoxifen	92-95	ubiquitin protein ligase E3A	Homo sapiens	52-56
22002941-3	2011	We conducted a trial using methylation-promoting dietary supplements (betaine, metafolin, creatine, and vitamin B(12) ) in an attempt to reduce antisense transcript production, increase UBE3A expression, and ameliorate the symptoms of AS.	Betaine	70-77	ubiquitin protein ligase E3A	Homo sapiens	186-191
22679561-8	2012	In addition, single cisplatin treatment was combined with the silencing of E6AP or p53.	Cisplatin	20-29	ubiquitin protein ligase E3A	Homo sapiens	75-79
22002941-3	2011	We conducted a trial using methylation-promoting dietary supplements (betaine, metafolin, creatine, and vitamin B(12) ) in an attempt to reduce antisense transcript production, increase UBE3A expression, and ameliorate the symptoms of AS.	levomefolate calcium	79-88	ubiquitin protein ligase E3A	Homo sapiens	186-191
22002941-3	2011	We conducted a trial using methylation-promoting dietary supplements (betaine, metafolin, creatine, and vitamin B(12) ) in an attempt to reduce antisense transcript production, increase UBE3A expression, and ameliorate the symptoms of AS.	Creatine	90-98	ubiquitin protein ligase E3A	Homo sapiens	186-191
22002941-3	2011	We conducted a trial using methylation-promoting dietary supplements (betaine, metafolin, creatine, and vitamin B(12) ) in an attempt to reduce antisense transcript production, increase UBE3A expression, and ameliorate the symptoms of AS.	Niacinamide	104-113	ubiquitin protein ligase E3A	Homo sapiens	186-191
21947926-0	2011	Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A.	Zinc	0-2	ubiquitin protein ligase E3A	Homo sapiens	57-62
21947926-3	2011	The structure of this domain  adopts a novel Zn-binding  fold we called AZUL (Amino-terminal Zn-finger of Ube3a Ligase).	Zinc	45-47	ubiquitin protein ligase E3A	Homo sapiens	106-111
20635355-5	2010	We conducted a trial using two dietary supplements, betaine and folic acid to promote global levels of methylation and attempt to activate the paternally inherited UBE3A gene.	Betaine	52-59	ubiquitin protein ligase E3A	Homo sapiens	164-169
20933619-5	2011	Our simulations showed that deletion of G538 destroys a network of salt bridges between highly conserved residues in the catalytic cleft of UBE3A.	g538	40-44	ubiquitin protein ligase E3A	Homo sapiens	140-145
20635355-5	2010	We conducted a trial using two dietary supplements, betaine and folic acid to promote global levels of methylation and attempt to activate the paternally inherited UBE3A gene.	Folic Acid	64-74	ubiquitin protein ligase E3A	Homo sapiens	164-169
20956852-0	2010	The role of calcium-dependent gene expression in autism spectrum disorders: lessons from MeCP2, Ube3a and beyond.	Calcium	12-19	ubiquitin protein ligase E3A	Homo sapiens	96-101
17426036-4	2007	However, the HECT domain E3s, E6AP and Nedd4, with the same E2, UbcH5, form homogeneous chains exclusively, either Lys(48) chains (E6AP) or Lys(63) chains (Nedd4).	Lysine	115-118	ubiquitin protein ligase E3A	Homo sapiens	30-34
19116316-2	2009	AIP4 belongs to the Nedd4-like homologous to E6-AP carboxy terminus domain family of E3 ubiquitin ligases, which typically bind proline-rich motifs within target proteins via the WW domains.	Proline	128-135	ubiquitin protein ligase E3A	Homo sapiens	45-50
18346513-3	2008	RESULTS: Relative to the control subjects, the [(11)C]flumazenil binding potentials (BPs) were significantly higher in the cerebral cortex and cerebellum in the 5 patients with the deletion and in the 1 patient with a UBE3A mutation, and were less frequently or barely increased in adult patients with the deletion and in the patient with IDs.	Flumazenil	54-64	ubiquitin protein ligase E3A	Homo sapiens	218-223
18256157-5	2008	Utilizing glutathione S-transferase pull-down and coimmunoprecipitation experiments, the beta-E6 proteins were shown to interact with the cellular proteins E6-associated protein (E6AP) and NFX1-91, two proteins known to be important for telomerase activation by 16E6.	Glutathione	10-21	ubiquitin protein ligase E3A	Homo sapiens	156-177
18256157-5	2008	Utilizing glutathione S-transferase pull-down and coimmunoprecipitation experiments, the beta-E6 proteins were shown to interact with the cellular proteins E6-associated protein (E6AP) and NFX1-91, two proteins known to be important for telomerase activation by 16E6.	Glutathione	10-21	ubiquitin protein ligase E3A	Homo sapiens	179-183
17426036-4	2007	However, the HECT domain E3s, E6AP and Nedd4, with the same E2, UbcH5, form homogeneous chains exclusively, either Lys(48) chains (E6AP) or Lys(63) chains (Nedd4).	Lysine	140-143	ubiquitin protein ligase E3A	Homo sapiens	30-34
17433363-5	2007	Alanine scanning of the E6AP-UbcH7 binding interface identified four side-chains on UbcH7 and six side-chains on E6AP that contribute more than 1 kcal/mol to the binding free energy.	Alanine	0-7	ubiquitin protein ligase E3A	Homo sapiens	113-117
17478484-0	2007	Evaluation of different glutathione S-transferase-tagged protein captures for screening E6/E6AP interaction inhibitors using AlphaScreen.	Glutathione	24-35	ubiquitin protein ligase E3A	Homo sapiens	91-95
17433363-5	2007	Alanine scanning of the E6AP-UbcH7 binding interface identified four side-chains on UbcH7 and six side-chains on E6AP that contribute more than 1 kcal/mol to the binding free energy.	Alanine	0-7	ubiquitin protein ligase E3A	Homo sapiens	24-28
17433363-7	2007	To determine if these are key specificity determining residues, we attempted to induce a tighter association between the E2 UbcH5b and E6AP by mutating the corresponding positions in UbcH5b to lysine residues.	Lysine	193-199	ubiquitin protein ligase E3A	Homo sapiens	135-139
14641994-7	2003	We conclude that dHPLC is a reliable and convenient method for detecting mutations in UBE3A causing Angelman syndrome.	dhplc	17-22	ubiquitin protein ligase E3A	Homo sapiens	86-91
16341092-5	2005	We show that E6AP builds up a K48-linked chain on its HECT cysteine residue, while KIAA10 builds up K48- and K29-linked chains as free entities.	Cysteine	59-67	ubiquitin protein ligase E3A	Homo sapiens	13-17
16869756-2	2005	This activity is dependent on association of E6 with E6AP, a cellular ubiquitin ligase.	Polyurethane Y-290	45-47	ubiquitin protein ligase E3A	Homo sapiens	53-57
16493710-6	2006	In the present study, a GST-fused E6AP protein was layered onto a glutathione (GSH)-modified gold chip surface.	Glutathione	66-77	ubiquitin protein ligase E3A	Homo sapiens	34-38
16493710-6	2006	In the present study, a GST-fused E6AP protein was layered onto a glutathione (GSH)-modified gold chip surface.	Glutathione	79-82	ubiquitin protein ligase E3A	Homo sapiens	34-38
16493710-7	2006	The specific binding of GST-E6AP protein onto the gold chip surface was facilitated through the affinity of GST to its specific ligand GSH.	Glutathione	135-138	ubiquitin protein ligase E3A	Homo sapiens	28-32
18528468-6	2006	In the presence of E6, E6AP catalyses the ubiquitylation and proteolysis of p53.	Polyurethane Y-290	19-21	ubiquitin protein ligase E3A	Homo sapiens	23-27
15890204-5	2005	Here we have investigated the kinetics of the interactions of a 15-mer peptide containing the LxxvarphiLsh motif of E6AP with E6.	lxxvarphilsh	94-106	ubiquitin protein ligase E3A	Homo sapiens	116-120
12944990-5	2003	Ribozyme-mediated reduction in E6AP expression was found to enhance the apoptotic response of HeLa cells to mitomycin C-induced DNA damage.	Mitomycin	108-119	ubiquitin protein ligase E3A	Homo sapiens	31-35
12771374-2	2003	Six independent folding trajectories, with a total duration of nearly 2 micros, all lead to the same native state in which the E6ap adopts a fluctuating alpha-helix structure in the central portion (Ser-4-Leu-13) but with very flexible N and C termini.	Serine	199-202	ubiquitin protein ligase E3A	Homo sapiens	127-131
12771374-4	2003	The essential leucine hydrophobic core (Leu-9, Leu-12, and Leu-13) is well conserved in the native-state structure but absent in the intermediate structure, suggesting that the leucine core is not only essential for the binding activity of E6ap but also important for the stability of the native structure.	Leucine	14-21	ubiquitin protein ligase E3A	Homo sapiens	240-244
12771374-4	2003	The essential leucine hydrophobic core (Leu-9, Leu-12, and Leu-13) is well conserved in the native-state structure but absent in the intermediate structure, suggesting that the leucine core is not only essential for the binding activity of E6ap but also important for the stability of the native structure.	Leucine	40-43	ubiquitin protein ligase E3A	Homo sapiens	240-244
12771374-4	2003	The essential leucine hydrophobic core (Leu-9, Leu-12, and Leu-13) is well conserved in the native-state structure but absent in the intermediate structure, suggesting that the leucine core is not only essential for the binding activity of E6ap but also important for the stability of the native structure.	Leucine	177-184	ubiquitin protein ligase E3A	Homo sapiens	240-244
12620801-9	2003	However, the interaction of 16E6 with E6AP was complex.	16e6	28-32	ubiquitin protein ligase E3A	Homo sapiens	38-42
12730723-2	2003	Recently we have identified a novel maternally expressed gene, ATP10C, that encodes a putative aminophospholipid translocase within this critical region, 200 kb distal to UBE3A in an imprinted domain on human chromosome 15.	aminophospholipid	95-112	ubiquitin protein ligase E3A	Homo sapiens	171-176
10723139-3	2000	We mutated the cysteine residue (C464) corresponding to the residue essential for the ubiquitin ligase activity of E6AP and this mutation diminished the ligase activity of MDM2.	Cysteine	15-23	ubiquitin protein ligase E3A	Homo sapiens	115-119
11775746-0	2001	1H, 15N and 13C assignments of the catalytic domain of E6-associated protein (E6AP).	Hydrogen	0-2	ubiquitin protein ligase E3A	Homo sapiens	55-76
11775746-0	2001	1H, 15N and 13C assignments of the catalytic domain of E6-associated protein (E6AP).	Hydrogen	0-2	ubiquitin protein ligase E3A	Homo sapiens	78-82
11775746-0	2001	1H, 15N and 13C assignments of the catalytic domain of E6-associated protein (E6AP).	15n	4-7	ubiquitin protein ligase E3A	Homo sapiens	55-76
11775746-0	2001	1H, 15N and 13C assignments of the catalytic domain of E6-associated protein (E6AP).	15n	4-7	ubiquitin protein ligase E3A	Homo sapiens	78-82
11775746-0	2001	1H, 15N and 13C assignments of the catalytic domain of E6-associated protein (E6AP).	13c	12-15	ubiquitin protein ligase E3A	Homo sapiens	55-76
11775746-0	2001	1H, 15N and 13C assignments of the catalytic domain of E6-associated protein (E6AP).	13c	12-15	ubiquitin protein ligase E3A	Homo sapiens	78-82
10864652-6	2000	In addition, both in vitro and in vivo experiments indicate that E6AP self-ubiquitination results primarily from an intramolecular transfer of ubiquitin from the active-site cysteine to one or more lysine residues; however, intermolecular transfer can also occur in the context of an E6-mediated E6AP multimer.	Cysteine	174-182	ubiquitin protein ligase E3A	Homo sapiens	65-69
10864652-6	2000	In addition, both in vitro and in vivo experiments indicate that E6AP self-ubiquitination results primarily from an intramolecular transfer of ubiquitin from the active-site cysteine to one or more lysine residues; however, intermolecular transfer can also occur in the context of an E6-mediated E6AP multimer.	Lysine	198-204	ubiquitin protein ligase E3A	Homo sapiens	65-69
10864652-6	2000	In addition, both in vitro and in vivo experiments indicate that E6AP self-ubiquitination results primarily from an intramolecular transfer of ubiquitin from the active-site cysteine to one or more lysine residues; however, intermolecular transfer can also occur in the context of an E6-mediated E6AP multimer.	Polyurethane Y-290	65-67	ubiquitin protein ligase E3A	Homo sapiens	296-300
11170455-6	2001	In the structure of the E6AP peptide, the three conserved leucines (Leu 9, Leu 12, and Leu 13) form a hydrophobic patch on one face of the alpha-helix.	Leucine	58-66	ubiquitin protein ligase E3A	Homo sapiens	24-28
11170455-6	2001	In the structure of the E6AP peptide, the three conserved leucines (Leu 9, Leu 12, and Leu 13) form a hydrophobic patch on one face of the alpha-helix.	Leucine	68-71	ubiquitin protein ligase E3A	Homo sapiens	24-28
11170455-8	2001	Mutation of a glutamate to proline, but not alanine, also disrupted the interaction between E6 and E6AP protein, suggesting that the E6-binding motif of the E6AP protein must be helical when bound to E6.	Glutamic Acid	14-23	ubiquitin protein ligase E3A	Homo sapiens	99-103
11170455-8	2001	Mutation of a glutamate to proline, but not alanine, also disrupted the interaction between E6 and E6AP protein, suggesting that the E6-binding motif of the E6AP protein must be helical when bound to E6.	Glutamic Acid	14-23	ubiquitin protein ligase E3A	Homo sapiens	157-161
11170455-8	2001	Mutation of a glutamate to proline, but not alanine, also disrupted the interaction between E6 and E6AP protein, suggesting that the E6-binding motif of the E6AP protein must be helical when bound to E6.	Proline	27-34	ubiquitin protein ligase E3A	Homo sapiens	99-103
11170455-8	2001	Mutation of a glutamate to proline, but not alanine, also disrupted the interaction between E6 and E6AP protein, suggesting that the E6-binding motif of the E6AP protein must be helical when bound to E6.	Proline	27-34	ubiquitin protein ligase E3A	Homo sapiens	157-161
10726657-4	2000	In this report, we describe the identification of efficient antisense oligonucleotides against human E6-AP.	Oligonucleotides	70-86	ubiquitin protein ligase E3A	Homo sapiens	101-106
10623743-3	2000	BE6 interacts strongly with each of these proteins in vitro, binding to similar peptide sequences found in E6AP, E6BP, and paxillin.	(2R,3R,4R,5R)-2,5-BIS[(2,5-DIFLUOROBENZYL)OXY]-3,4-DIHYDROXY-N,N'-BIS[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]HEXANEDIAMIDE	0-3	ubiquitin protein ligase E3A	Homo sapiens	107-111
10449731-5	1999	Studies aimed at the identification of cellular targets for E6AP, an E3 ubiquitin protein ligase involved in ubquitin-mediated degradation, led us to the identification of members of the Src family kinases as potential substrates for E6AP.	ubquitin	109-117	ubiquitin protein ligase E3A	Homo sapiens	60-64
10449731-5	1999	Studies aimed at the identification of cellular targets for E6AP, an E3 ubiquitin protein ligase involved in ubquitin-mediated degradation, led us to the identification of members of the Src family kinases as potential substrates for E6AP.	ubquitin	109-117	ubiquitin protein ligase E3A	Homo sapiens	234-238
10066826-4	1999	We show here, by the use of chimeric E2s generated between UbcH5 and other E2s, that a region of UbcH5 encompassing the catalytic site cysteine residue is critical for its ability to interact with E6-AP and RSP5.	Estradiol	37-40	ubiquitin protein ligase E3A	Homo sapiens	197-202
10066826-4	1999	We show here, by the use of chimeric E2s generated between UbcH5 and other E2s, that a region of UbcH5 encompassing the catalytic site cysteine residue is critical for its ability to interact with E6-AP and RSP5.	Estradiol	75-78	ubiquitin protein ligase E3A	Homo sapiens	197-202
10066826-4	1999	We show here, by the use of chimeric E2s generated between UbcH5 and other E2s, that a region of UbcH5 encompassing the catalytic site cysteine residue is critical for its ability to interact with E6-AP and RSP5.	Cysteine	135-143	ubiquitin protein ligase E3A	Homo sapiens	197-202
9545097-8	1998	Candidate genes involved in the 15q region affected by duplication and deletion include the ubiquitin-protein ligase (UBE3A) gene responsible for Angelman syndrome and genes for three GABA(A) receptor subunits.	gamma-Aminobutyric Acid	184-188	ubiquitin protein ligase E3A	Homo sapiens	118-123
9467941-3	1998	The LD motifs of paxillin that bind BE6 share homology with the E6 binding site of E6-AP, a ubiquitin ligase that together with 16E6 targets the degradation of the p53 tumor suppressor.	(2R,3R,4R,5R)-2,5-BIS[(2,5-DIFLUOROBENZYL)OXY]-3,4-DIHYDROXY-N,N'-BIS[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]HEXANEDIAMIDE	36-39	ubiquitin protein ligase E3A	Homo sapiens	83-88
9467941-5	1998	Mutational analysis of BE6 can distinguish the interaction of BE6 with E6-AP compared to paxillin and revealed that the interaction of BE6 with paxillin may be necessary for the induction of anchorage independent growth of cells by BE6.	(2R,3R,4R,5R)-2,5-BIS[(2,5-DIFLUOROBENZYL)OXY]-3,4-DIHYDROXY-N,N'-BIS[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]HEXANEDIAMIDE	23-26	ubiquitin protein ligase E3A	Homo sapiens	71-76
9151888-2	1997	These BE6 mutants demonstrate that transformation by BE6 does not require transcriptional activation and that association of BE6 with E6-AP is a function separable from transcriptional activation by BE6.	(2R,3R,4R,5R)-2,5-BIS[(2,5-DIFLUOROBENZYL)OXY]-3,4-DIHYDROXY-N,N'-BIS[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]HEXANEDIAMIDE	6-9	ubiquitin protein ligase E3A	Homo sapiens	134-139
9467941-5	1998	Mutational analysis of BE6 can distinguish the interaction of BE6 with E6-AP compared to paxillin and revealed that the interaction of BE6 with paxillin may be necessary for the induction of anchorage independent growth of cells by BE6.	(2R,3R,4R,5R)-2,5-BIS[(2,5-DIFLUOROBENZYL)OXY]-3,4-DIHYDROXY-N,N'-BIS[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]HEXANEDIAMIDE	62-65	ubiquitin protein ligase E3A	Homo sapiens	71-76
9467941-5	1998	Mutational analysis of BE6 can distinguish the interaction of BE6 with E6-AP compared to paxillin and revealed that the interaction of BE6 with paxillin may be necessary for the induction of anchorage independent growth of cells by BE6.	(2R,3R,4R,5R)-2,5-BIS[(2,5-DIFLUOROBENZYL)OXY]-3,4-DIHYDROXY-N,N'-BIS[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]HEXANEDIAMIDE	62-65	ubiquitin protein ligase E3A	Homo sapiens	71-76
9467941-5	1998	Mutational analysis of BE6 can distinguish the interaction of BE6 with E6-AP compared to paxillin and revealed that the interaction of BE6 with paxillin may be necessary for the induction of anchorage independent growth of cells by BE6.	(2R,3R,4R,5R)-2,5-BIS[(2,5-DIFLUOROBENZYL)OXY]-3,4-DIHYDROXY-N,N'-BIS[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]HEXANEDIAMIDE	62-65	ubiquitin protein ligase E3A	Homo sapiens	71-76
9151888-2	1997	These BE6 mutants demonstrate that transformation by BE6 does not require transcriptional activation and that association of BE6 with E6-AP is a function separable from transcriptional activation by BE6.	(2R,3R,4R,5R)-2,5-BIS[(2,5-DIFLUOROBENZYL)OXY]-3,4-DIHYDROXY-N,N'-BIS[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]HEXANEDIAMIDE	53-56	ubiquitin protein ligase E3A	Homo sapiens	134-139
9151888-3	1997	Association of BE6 with E6-AP appears to be necessary but not sufficient for transformation by BE6.	(2R,3R,4R,5R)-2,5-BIS[(2,5-DIFLUOROBENZYL)OXY]-3,4-DIHYDROXY-N,N'-BIS[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]HEXANEDIAMIDE	15-18	ubiquitin protein ligase E3A	Homo sapiens	24-29
9153201-8	1997	Furthermore, we show that UbcH5 and UbcH6, two highly homologous E2s that were deficient for interaction with E6AP, could associate efficiently with another Hect-E3 protein, RSP5.	Estradiol	65-68	ubiquitin protein ligase E3A	Homo sapiens	110-114
9153201-9	1997	Finally, only the E6AP-interacting E2s could function in conjunction with E6AP in the ubiquitination of an E6 independent substrate of E6AP, whereas the noninteracting E2s could not.	Estradiol	35-38	ubiquitin protein ligase E3A	Homo sapiens	18-22
9153201-9	1997	Finally, only the E6AP-interacting E2s could function in conjunction with E6AP in the ubiquitination of an E6 independent substrate of E6AP, whereas the noninteracting E2s could not.	Estradiol	35-38	ubiquitin protein ligase E3A	Homo sapiens	74-78
9153201-9	1997	Finally, only the E6AP-interacting E2s could function in conjunction with E6AP in the ubiquitination of an E6 independent substrate of E6AP, whereas the noninteracting E2s could not.	Estradiol	35-38	ubiquitin protein ligase E3A	Homo sapiens	74-78
9153201-9	1997	Finally, only the E6AP-interacting E2s could function in conjunction with E6AP in the ubiquitination of an E6 independent substrate of E6AP, whereas the noninteracting E2s could not.	Estradiol	168-171	ubiquitin protein ligase E3A	Homo sapiens	18-22
9153201-9	1997	Finally, only the E6AP-interacting E2s could function in conjunction with E6AP in the ubiquitination of an E6 independent substrate of E6AP, whereas the noninteracting E2s could not.	Estradiol	168-171	ubiquitin protein ligase E3A	Homo sapiens	74-78
9153201-9	1997	Finally, only the E6AP-interacting E2s could function in conjunction with E6AP in the ubiquitination of an E6 independent substrate of E6AP, whereas the noninteracting E2s could not.	Estradiol	168-171	ubiquitin protein ligase E3A	Homo sapiens	74-78
34202736-3	2021	E6 induces anti-apoptosis by degrading tumor suppressor proteins p53 (p53) via E6-E6-associated protein (E6AP)-mediated polyubiquitination.	Polyurethane Y-290	0-2	ubiquitin protein ligase E3A	Homo sapiens	105-109
7478539-2	1995	UREB1, a DNA binding protein that is tyrosine phosphorylated in vivo, shares a significant homology with the human papilloma virus E6 associated protein (E6-AP).	Tyrosine	37-45	ubiquitin protein ligase E3A	Homo sapiens	154-159
34467244-2	2021	Here, we study neurons derived from patients with AS and neurotypical individuals, and reciprocally modulate UBE3A using antisense oligonucleotides.	Oligonucleotides	131-147	ubiquitin protein ligase E3A	Homo sapiens	109-114
34467252-0	2021	A protein regulated by UBE3A PEGs a potential biomarker.	pegs	29-33	ubiquitin protein ligase E3A	Homo sapiens	23-28
8530467-6	1995	Both UbcH5B and UbcH5C form thiol ester adducts with ubiquitin, and have activities similar to UbcH5A and AtUBC8 in the conjugation of ubiquitin to target proteins in the presence of the human ubiquitin protein ligase E6-AP.	ubch5c	16-22	ubiquitin protein ligase E3A	Homo sapiens	218-223
7800044-6	1995	The cysteine residue of E6-AP responsible for ubiquitin thioester formation was mapped to a region that is highly conserved among several proteins of unknown function, suggesting that these proteins share the ability to form thioesters with ubiquitin.	Cysteine	4-12	ubiquitin protein ligase E3A	Homo sapiens	24-29
34638625-3	2021	We also found that the expression of E6AP in HeLa cells with the endogenous expression of the E6 protein of the human papillomavirus (HPV) would accelerate OGT degradation by the proteasome and suppress O-GlcNAc modification of OGT substrates in the cell.	o-glcnac	203-211	ubiquitin protein ligase E3A	Homo sapiens	37-41
33543479-7	2021	A particular promising strategy is an antisense oligonucleotide approach, which activates the silenced paternal UBE3A gene.	Oligonucleotides	48-63	ubiquitin protein ligase E3A	Homo sapiens	112-117
35467269-8	2022	Molecular docking showed that l- menthol targeted E6, E6AP and E7 onco-proteins of HPV that interact and inactivate TP53 and Rb1 in cervical cancer, respectively.	Menthol	30-40	ubiquitin protein ligase E3A	Homo sapiens	54-58
35066375-0	2022	All-trans retinoic acid inhibits HCV replication by downregulating core levels via E6AP-mediated proteasomal degradation.	Tretinoin	10-23	ubiquitin protein ligase E3A	Homo sapiens	83-87
35066375-1	2022	Here, we found that all-trans retinoic acid (ATRA), the most biologically active metabolite of vitamin A, strengthens the anti-viral defense mechanism of E6-associated protein (E6AP) that downregulates hepatitis C virus (HCV) Core levels via ubiquitin-dependent proteasomal degradation.	Tretinoin	23-43	ubiquitin protein ligase E3A	Homo sapiens	177-181
35066375-1	2022	Here, we found that all-trans retinoic acid (ATRA), the most biologically active metabolite of vitamin A, strengthens the anti-viral defense mechanism of E6-associated protein (E6AP) that downregulates hepatitis C virus (HCV) Core levels via ubiquitin-dependent proteasomal degradation.	Tretinoin	45-49	ubiquitin protein ligase E3A	Homo sapiens	177-181
35066375-1	2022	Here, we found that all-trans retinoic acid (ATRA), the most biologically active metabolite of vitamin A, strengthens the anti-viral defense mechanism of E6-associated protein (E6AP) that downregulates hepatitis C virus (HCV) Core levels via ubiquitin-dependent proteasomal degradation.	Vitamin A	95-104	ubiquitin protein ligase E3A	Homo sapiens	177-181
35066375-2	2022	For this effect, ATRA downregulated both protein and enzyme activity levels of DNA methyltransferase 1 and 3b and activated E6AP expression via promoter hypomethylation in HepG2 cells but not in Hep3B cells, in which p53 was absent.	Tretinoin	17-21	ubiquitin protein ligase E3A	Homo sapiens	124-128
35066375-3	2022	Ectopic p53 expression but not E6AP overexpression restored the ability of ATRA to downregulate HCV Core levels in Hep3B cells, suggesting a direct role of p53 in the E6AP-mediated ubiquitination of HCV Core.	Tretinoin	75-79	ubiquitin protein ligase E3A	Homo sapiens	167-171
35045253-0	2022	Activation of E6AP/UBE3A-Mediated Protein Ubiquitination and Degradation Pathways by a Cyclic gamma-AA Peptide.	cyclic gamma-aa peptide	87-110	ubiquitin protein ligase E3A	Homo sapiens	14-18
35045253-0	2022	Activation of E6AP/UBE3A-Mediated Protein Ubiquitination and Degradation Pathways by a Cyclic gamma-AA Peptide.	cyclic gamma-aa peptide	87-110	ubiquitin protein ligase E3A	Homo sapiens	19-24
35045253-3	2022	We found that a gamma-AA peptide P6, discovered from the affinity-based screening with the E6AP HECT domain, can significantly stimulate the ubiquitin ligase activity of E6AP to ubiquitinate its substrate proteins UbxD8, HHR23A, and beta-catenin in reconstituted reactions and HEK293T cells.	gamma-aa	16-24	ubiquitin protein ligase E3A	Homo sapiens	91-95
35045253-3	2022	We found that a gamma-AA peptide P6, discovered from the affinity-based screening with the E6AP HECT domain, can significantly stimulate the ubiquitin ligase activity of E6AP to ubiquitinate its substrate proteins UbxD8, HHR23A, and beta-catenin in reconstituted reactions and HEK293T cells.	gamma-aa	16-24	ubiquitin protein ligase E3A	Homo sapiens	170-174
35045253-4	2022	Furthermore, P6 can accelerate the degradation of E6AP substrates in the cell by enhancing the catalytic activities of E6AP.	PS-6	13-15	ubiquitin protein ligase E3A	Homo sapiens	50-54
35045253-4	2022	Furthermore, P6 can accelerate the degradation of E6AP substrates in the cell by enhancing the catalytic activities of E6AP.	PS-6	13-15	ubiquitin protein ligase E3A	Homo sapiens	119-123
35611307-2	2022	Antisense oligonucleotide therapies are under development to reinstate UBE3A protein production.	Oligonucleotides	10-25	ubiquitin protein ligase E3A	Homo sapiens	71-76
35611307-11	2022	Deviations in delta power from a human natural history model in Angelman syndrome can detect antisense oligonucleotide-mediated improvement in Ube3a expression in Angelman syndrome mice and may be relevant for human clinical trials.	Oligonucleotides	103-118	ubiquitin protein ligase E3A	Homo sapiens	143-148
31971989-5	2020	In Type II interactions, E6 proteins require additional auxiliary regions of E6AP in either the amino terminus or in the carboxy-terminal HECT domain to interact with the LXXLL peptide motif of E6AP.	Amino Acids	96-101	ubiquitin protein ligase E3A	Homo sapiens	77-81
32893075-12	2021	Activation of the intact but silent paternal copy of UBE3A (antisense oligonucleotide therapy and artificial transcription factors); and 3.	Oligonucleotides	70-85	ubiquitin protein ligase E3A	Homo sapiens	53-58
32889787-7	2020	In line with this, functional analysis of the UBE3A p.Asn340del mutant protein revealed no major deficits in UBE3A protein localization, stability, or E3 ubiquitin ligase activity.	asn340del	54-63	ubiquitin protein ligase E3A	Homo sapiens	46-51
31971989-5	2020	In Type II interactions, E6 proteins require additional auxiliary regions of E6AP in either the amino terminus or in the carboxy-terminal HECT domain to interact with the LXXLL peptide motif of E6AP.	Amino Acids	96-101	ubiquitin protein ligase E3A	Homo sapiens	194-198
31971989-5	2020	In Type II interactions, E6 proteins require additional auxiliary regions of E6AP in either the amino terminus or in the carboxy-terminal HECT domain to interact with the LXXLL peptide motif of E6AP.	carboxy phosphate	121-128	ubiquitin protein ligase E3A	Homo sapiens	194-198
31971989-6	2020	A region of E6AP amino-terminal to the LXXLL peptide motif both augments association with E6 proteins and is required for E6 proteins to trigger ubiquitin ligase activity in the carboxy-terminal HECT ubiquitin ligase domain of E6AP.	Amino Acids	17-22	ubiquitin protein ligase E3A	Homo sapiens	12-16
31971989-6	2020	A region of E6AP amino-terminal to the LXXLL peptide motif both augments association with E6 proteins and is required for E6 proteins to trigger ubiquitin ligase activity in the carboxy-terminal HECT ubiquitin ligase domain of E6AP.	Amino Acids	17-22	ubiquitin protein ligase E3A	Homo sapiens	227-231
31971989-6	2020	A region of E6AP amino-terminal to the LXXLL peptide motif both augments association with E6 proteins and is required for E6 proteins to trigger ubiquitin ligase activity in the carboxy-terminal HECT ubiquitin ligase domain of E6AP.	carboxy phosphate	178-185	ubiquitin protein ligase E3A	Homo sapiens	12-16
31971989-6	2020	A region of E6AP amino-terminal to the LXXLL peptide motif both augments association with E6 proteins and is required for E6 proteins to trigger ubiquitin ligase activity in the carboxy-terminal HECT ubiquitin ligase domain of E6AP.	carboxy phosphate	178-185	ubiquitin protein ligase E3A	Homo sapiens	227-231
31971989-9	2020	This classification of E6-E6AP interaction types and identification of a region in the E6AP amino terminus that is important for both E6 association and stimulation of ubiquitin ligase activity will inform future structural data of the E6-E6AP complex and future studies aiming to interfere with the activity of the E6-E6AP complex.	Amino Acids	92-97	ubiquitin protein ligase E3A	Homo sapiens	26-30
31949242-5	2020	E6AP was expressed higher in HSCs than hepatocytes, and was up-regulated in activated HSCs, HSCs from the livers of carbon tetrachloride-injected mice, or TGF-beta-treated LX-2 cells.	Carbon Tetrachloride	116-136	ubiquitin protein ligase E3A	Homo sapiens	0-4
31681945-0	2020	UBE3A alleviates isoproterenol-induced cardiac hypertrophy through the inhibition of the TLR4/MMP-9 signaling pathway.	Isoproterenol	17-30	ubiquitin protein ligase E3A	Homo sapiens	0-5
31681945-3	2020	Our results showed that isoproterenol induced cardiac hypertrophy in AC16 cells, as reflected by the increased cell surface area and increased hypertrophic markers, which was accompanied by increased ubiquitin-protein ligase E3a (UBE3A) expression.	Isoproterenol	24-37	ubiquitin protein ligase E3A	Homo sapiens	230-235
31681945-4	2020	Moreover, UBE3A knockdown by siRNAs accelerated cardiac hypertrophy, suggesting that increased UBE3A expression induced by isoproterenol might be a protective response and UBE3A might be a protective factor against cardiac hypertrophy.	Isoproterenol	123-136	ubiquitin protein ligase E3A	Homo sapiens	10-15
31681945-4	2020	Moreover, UBE3A knockdown by siRNAs accelerated cardiac hypertrophy, suggesting that increased UBE3A expression induced by isoproterenol might be a protective response and UBE3A might be a protective factor against cardiac hypertrophy.	Isoproterenol	123-136	ubiquitin protein ligase E3A	Homo sapiens	95-100
31681945-4	2020	Moreover, UBE3A knockdown by siRNAs accelerated cardiac hypertrophy, suggesting that increased UBE3A expression induced by isoproterenol might be a protective response and UBE3A might be a protective factor against cardiac hypertrophy.	Isoproterenol	123-136	ubiquitin protein ligase E3A	Homo sapiens	95-100
31857479-3	2019	Using human neurons and brain organoids, we demonstrate that UBE3A suppresses neuronal hyperexcitability via ubiquitin-mediated degradation of calcium- and voltage-dependent big potassium (BK) channels.	Calcium	143-150	ubiquitin protein ligase E3A	Homo sapiens	61-66
31490639-3	2020	Antisense oligonucleotides and gene therapies are in development, which activate the intact but epigenetically silenced paternal UBE3A allele.	Oligonucleotides	10-26	ubiquitin protein ligase E3A	Homo sapiens	129-134
31526948-7	2020	The cytotoxic effect of curcumin in cervical cancer cells was related to the complex p53-NQO1 that avoids the interaction between p53 and its negative regulator ubiquitin ligase E6-associated protein (E6AP).	Curcumin	24-32	ubiquitin protein ligase E3A	Homo sapiens	178-199
31526948-7	2020	The cytotoxic effect of curcumin in cervical cancer cells was related to the complex p53-NQO1 that avoids the interaction between p53 and its negative regulator ubiquitin ligase E6-associated protein (E6AP).	Curcumin	24-32	ubiquitin protein ligase E3A	Homo sapiens	201-205
31329371-3	2019	In the present study, we applied nano-LC based proteomics approach to identify E6AP-interacting proteins where we performed GST-pull down using GST-E6AP from whole cell extracts of MCF7 cells, resolved the differentially interacting proteins on 1D-SDS-PAGE, excised the gel bands that were trypsin digested followed by fractionation and spotting on MALDI-TOF/TOF plate through Nano-LC MALDI spotter.	Sodium Dodecyl Sulfate	248-251	ubiquitin protein ligase E3A	Homo sapiens	79-83
31329371-3	2019	In the present study, we applied nano-LC based proteomics approach to identify E6AP-interacting proteins where we performed GST-pull down using GST-E6AP from whole cell extracts of MCF7 cells, resolved the differentially interacting proteins on 1D-SDS-PAGE, excised the gel bands that were trypsin digested followed by fractionation and spotting on MALDI-TOF/TOF plate through Nano-LC MALDI spotter.	Sodium Dodecyl Sulfate	248-251	ubiquitin protein ligase E3A	Homo sapiens	148-152
31004355-4	2019	Here, we show that Myricetin, a flavonoid, can eliminate various abnormal proteins from the cellular environment via modulating endogenous levels of Hsp70 chaperone and quality control (QC)-E3 ubiquitin ligase E6-AP.	myricetin	19-28	ubiquitin protein ligase E3A	Homo sapiens	210-215
31004355-4	2019	Here, we show that Myricetin, a flavonoid, can eliminate various abnormal proteins from the cellular environment via modulating endogenous levels of Hsp70 chaperone and quality control (QC)-E3 ubiquitin ligase E6-AP.	Flavonoids	32-41	ubiquitin protein ligase E3A	Homo sapiens	210-215
31004355-7	2019	Remarkably, Myricetin can also stabilize E6-AP and reduce the misfolded proteins inclusions, which further alleviates cytotoxicity.	myricetin	12-21	ubiquitin protein ligase E3A	Homo sapiens	41-46
30664221-10	2019	Furthermore, molecular docking demonstrated that quercetin binds stably in the central pocket of E6, the binding site of E6AP.	Quercetin	49-58	ubiquitin protein ligase E3A	Homo sapiens	121-125
30737286-8	2019	Intriguingly, mutation of Glu-51, a single residue within this region, permits formation of alternative chain types, thus pointing to a key role of ubiquitin in conferring linkage specificity to E6AP.	Glutamic Acid	26-29	ubiquitin protein ligase E3A	Homo sapiens	195-199
31202261-7	2019	The autism-associated gene ubiquitin-protein ligase E3A (UBE3A) has been reported to influence WNT, BMP, and RA signaling pathways, suggesting crosstalk between various signaling pathways during autistic brain development.	Tretinoin	109-111	ubiquitin protein ligase E3A	Homo sapiens	27-55
31202261-7	2019	The autism-associated gene ubiquitin-protein ligase E3A (UBE3A) has been reported to influence WNT, BMP, and RA signaling pathways, suggesting crosstalk between various signaling pathways during autistic brain development.	Tretinoin	109-111	ubiquitin protein ligase E3A	Homo sapiens	57-62
30664221-11	2019	These data suggest that quercetin increases the nuclear localization of p53 by interrupting E6/E6AP complex formation in cervical cancer cells.	Quercetin	24-33	ubiquitin protein ligase E3A	Homo sapiens	95-99
30257870-0	2018	Angelman syndrome-associated point mutations in the Zn2+-binding N-terminal (AZUL) domain of UBE3A ubiquitin ligase inhibit binding to the proteasome.	Zinc	52-56	ubiquitin protein ligase E3A	Homo sapiens	93-98
30257870-4	2018	We map the interaction to the highly conserved Zn2+-binding N-terminal (AZUL) domain of UBE3A, the integrity of which is crucial for binding to PSMD4.	Zinc	47-51	ubiquitin protein ligase E3A	Homo sapiens	88-93
28678681-7	2018	Furthermore, we observe tissue-specific monoallelic enrichment of 5hmC overlapping large clusters of imprinted snoRNAs-miRNAs processed from long noncoding RNAs (lncRNAs) within the DLK1-DIO3 cluster on chromosome 14 and SNRPN-UBE3A domain on chromosome 15.	5hmc	66-70	ubiquitin protein ligase E3A	Homo sapiens	227-232
29643511-3	2018	By contrast, "homologous to E6-AP carboxy terminus" (HECT) E3 ligases undergo a catalytic cysteine-dependent transthiolation reaction with E2-Ub, forming a covalent E3-Ub intermediate3,4.	Cysteine	90-98	ubiquitin protein ligase E3A	Homo sapiens	28-33
29643511-3	2018	By contrast, "homologous to E6-AP carboxy terminus" (HECT) E3 ligases undergo a catalytic cysteine-dependent transthiolation reaction with E2-Ub, forming a covalent E3-Ub intermediate3,4.	e2-ub	139-144	ubiquitin protein ligase E3A	Homo sapiens	28-33
29076503-3	2018	Here we report that the functionality of ALDH1A2, the rate-limiting enzyme of retinoic acid (RA) synthesis, is negatively regulated by UBE3A in a ubiquitylation-dependent manner.	Tretinoin	78-91	ubiquitin protein ligase E3A	Homo sapiens	135-140
30287686-5	2018	Homology modeling to E6AP revealed that the predicted intersubunit interface has an absolutely conserved Phe-823, substitution of which destabilized the trimer and resulted in a >=104-fold decrease in k cat for polyubiquitin chain assembly.	Phenylalanine	105-108	ubiquitin protein ligase E3A	Homo sapiens	21-25
29931810-5	2018	The Cu2+ complex interacts with E6 at the E6AP and p53 binding sites.	cupric ion	4-8	ubiquitin protein ligase E3A	Homo sapiens	42-46
27658027-10	2016	Curiously, when compared to the known Homo sapiens proteome, the representation of tryptophan in the HR-HPV E6 & E6AP degradome is substantially lower, possibly providing a mechanism that underlies the lowered intracellular free tryptophan levels in E6-expressing cells during starvation.	Tryptophan	83-93	ubiquitin protein ligase E3A	Homo sapiens	117-121
29076503-0	2018	Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders.	retinoic	31-39	ubiquitin protein ligase E3A	Homo sapiens	10-15
29188609-5	2017	RESULTS: DNA sequencing showed the proband of family 1 has carried a novel maternal UBE3A splice acceptor site mutation, resulting in a guanine-to-cytosine transversion (IVS15-1G>C).	Guanine	136-143	ubiquitin protein ligase E3A	Homo sapiens	84-89
29188609-5	2017	RESULTS: DNA sequencing showed the proband of family 1 has carried a novel maternal UBE3A splice acceptor site mutation, resulting in a guanine-to-cytosine transversion (IVS15-1G>C).	Cytosine	147-155	ubiquitin protein ligase E3A	Homo sapiens	84-89
28436452-4	2017	These patient-specific differences were mimicked by knocking out UBE3A using CRISPR/Cas9 or by knocking down UBE3A using antisense oligonucleotides.	Oligonucleotides	131-147	ubiquitin protein ligase E3A	Homo sapiens	109-114
26915086-6	2016	To develop insights useful for potential structure-based design of ligands for HPV E6, a series of 2,6-disubstituted benzopyranones were prepared and tested as competitive antagonists of E6-E6AP helix-groove interactions.	2,6-disubstituted benzopyranones	99-131	ubiquitin protein ligase E3A	Homo sapiens	190-194
26506232-4	2016	Wild-type E6AP promoted proteasome dependent degradation of MNT, while catalytically inactive E6AP having cysteine replaced with alanine at amino-acid 843 position (E6APC843A) rather stabilized it.	Cysteine	106-114	ubiquitin protein ligase E3A	Homo sapiens	94-98
26506232-4	2016	Wild-type E6AP promoted proteasome dependent degradation of MNT, while catalytically inactive E6AP having cysteine replaced with alanine at amino-acid 843 position (E6APC843A) rather stabilized it.	Alanine	129-136	ubiquitin protein ligase E3A	Homo sapiens	94-98
26506232-7	2016	We further showed that ATRA inhibited E6AP and stabilized MNT expression by protecting it from E6AP mediated ubiquitin-proteasome degradation.	Tretinoin	23-27	ubiquitin protein ligase E3A	Homo sapiens	38-42
26506232-7	2016	We further showed that ATRA inhibited E6AP and stabilized MNT expression by protecting it from E6AP mediated ubiquitin-proteasome degradation.	Tretinoin	23-27	ubiquitin protein ligase E3A	Homo sapiens	95-99
26628634-7	2016	Work is progressing on the use of ASOs to activate the normally silent paternal copy of the imprinted UBE3A gene in neurons as a treatment for Angelman syndrome.	Oligonucleotides, Antisense	34-38	ubiquitin protein ligase E3A	Homo sapiens	102-107
26869263-0	2016	Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation.	gamma-Aminobutyric Acid	52-56	ubiquitin protein ligase E3A	Homo sapiens	8-13
26869263-0	2016	Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation.	nac	85-88	ubiquitin protein ligase E3A	Homo sapiens	8-13
26869263-3	2016	Here we demonstrate that loss of the E3-ubiquitin ligase, UBE3A, from tyrosine hydroxylase-expressing neurons impairs mesoaccumbal, non-canonical GABA co-release and enhances reward-seeking behaviour measured by optical self-stimulation.	gamma-Aminobutyric Acid	146-150	ubiquitin protein ligase E3A	Homo sapiens	58-63
26789255-4	2016	In this process, E6 binds to a short leucine (L)-rich LxxLL consensus sequence within the cellular ubiquitin ligase E6AP.	Polyurethane Y-290	17-19	ubiquitin protein ligase E3A	Homo sapiens	116-120
26216987-4	2015	Here, we provide evidence that the hydrophobic patch of ubiquitin comprising Leu-8 and Ile-44 is important for E6AP-mediated ubiquitination, whereas it does not affect the catalytic properties of the isolated catalytic HECT domain of E6AP.	Isoleucine	87-90	ubiquitin protein ligase E3A	Homo sapiens	111-115
26794656-6	2016	Both compounds clearly inhibited the ability of E6 to bind in vitro to both caspase 8 and E6AP, the protein that mediates p53 degradation.	Polyurethane Y-290	48-50	ubiquitin protein ligase E3A	Homo sapiens	90-94
26363225-10	2015	In this model ERalpha, apoptotic proteins, and cell cycle proteins, all influenced by melatonin, are substrates of key ubiquitin ligases including SCF(Skp2), E6AP, and SCF(B-TrCP).	Melatonin	86-95	ubiquitin protein ligase E3A	Homo sapiens	158-162
25408199-5	2015	Apigenin-treated cells exhibited increased ER-beta interactions with ubiquitin-protein ligase E6AP, downregulated PSMA5 (alpha-5 subunit for assembly of 20S proteasome) without affecting PSMB1 (beta-1 subunit), PSMB2 (beta-2 subunit) and PSMB5 (beta-5 subunit, whose overexpression by bortezomib causes drug resistance) of proteasome at mRNA levels.	Apigenin	0-8	ubiquitin protein ligase E3A	Homo sapiens	94-98
26261538-3	2015	RESULTS: Stably transfected LNCaP cells that over expressed E6-AP had higher expression levels of PI3K, Akt, and mTOR than control LNCaP cells; MTT assay showed that E6-AP-LNCaP cells were more responsive to the inhibitory effect of LY294002; Matrigel invasion chamber assay revealed increased cell crawling and adhesiveness of E6-AP-LNCaP cells.	monooxyethylene trimethylolpropane tristearate	144-147	ubiquitin protein ligase E3A	Homo sapiens	60-65
26161728-3	2015	Using these cross-linkers, we identified covalent modifications of the E6AP catalytic cysteine and two lysines: Lys(847) and Lys(799).	Cysteine	86-94	ubiquitin protein ligase E3A	Homo sapiens	71-75
26161728-3	2015	Using these cross-linkers, we identified covalent modifications of the E6AP catalytic cysteine and two lysines: Lys(847) and Lys(799).	Lysine	112-115	ubiquitin protein ligase E3A	Homo sapiens	71-75
26161728-3	2015	Using these cross-linkers, we identified covalent modifications of the E6AP catalytic cysteine and two lysines: Lys(847) and Lys(799).	Lysine	125-128	ubiquitin protein ligase E3A	Homo sapiens	71-75
26161728-5	2015	Thus, opposing roles of Lys(799) and Lys(847) pave the path forward to pharmacological inhibitors or activators of E6AP for therapeutic purposes.	Lysine	24-27	ubiquitin protein ligase E3A	Homo sapiens	115-119
26161728-5	2015	Thus, opposing roles of Lys(799) and Lys(847) pave the path forward to pharmacological inhibitors or activators of E6AP for therapeutic purposes.	Lysine	37-40	ubiquitin protein ligase E3A	Homo sapiens	115-119
26261538-3	2015	RESULTS: Stably transfected LNCaP cells that over expressed E6-AP had higher expression levels of PI3K, Akt, and mTOR than control LNCaP cells; MTT assay showed that E6-AP-LNCaP cells were more responsive to the inhibitory effect of LY294002; Matrigel invasion chamber assay revealed increased cell crawling and adhesiveness of E6-AP-LNCaP cells.	monooxyethylene trimethylolpropane tristearate	144-147	ubiquitin protein ligase E3A	Homo sapiens	166-171
26261538-3	2015	RESULTS: Stably transfected LNCaP cells that over expressed E6-AP had higher expression levels of PI3K, Akt, and mTOR than control LNCaP cells; MTT assay showed that E6-AP-LNCaP cells were more responsive to the inhibitory effect of LY294002; Matrigel invasion chamber assay revealed increased cell crawling and adhesiveness of E6-AP-LNCaP cells.	monooxyethylene trimethylolpropane tristearate	144-147	ubiquitin protein ligase E3A	Homo sapiens	166-171
26261538-3	2015	RESULTS: Stably transfected LNCaP cells that over expressed E6-AP had higher expression levels of PI3K, Akt, and mTOR than control LNCaP cells; MTT assay showed that E6-AP-LNCaP cells were more responsive to the inhibitory effect of LY294002; Matrigel invasion chamber assay revealed increased cell crawling and adhesiveness of E6-AP-LNCaP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	233-241	ubiquitin protein ligase E3A	Homo sapiens	60-65
26261538-3	2015	RESULTS: Stably transfected LNCaP cells that over expressed E6-AP had higher expression levels of PI3K, Akt, and mTOR than control LNCaP cells; MTT assay showed that E6-AP-LNCaP cells were more responsive to the inhibitory effect of LY294002; Matrigel invasion chamber assay revealed increased cell crawling and adhesiveness of E6-AP-LNCaP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	233-241	ubiquitin protein ligase E3A	Homo sapiens	166-171
26261538-3	2015	RESULTS: Stably transfected LNCaP cells that over expressed E6-AP had higher expression levels of PI3K, Akt, and mTOR than control LNCaP cells; MTT assay showed that E6-AP-LNCaP cells were more responsive to the inhibitory effect of LY294002; Matrigel invasion chamber assay revealed increased cell crawling and adhesiveness of E6-AP-LNCaP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	233-241	ubiquitin protein ligase E3A	Homo sapiens	166-171
25355869-9	2015	Among these four bNAbs, avidity for UBE3A was correlated with neutralization breadth.	bnabs	17-22	ubiquitin protein ligase E3A	Homo sapiens	36-41
25470045-6	2015	Here we developed a potential therapeutic intervention for Angelman syndrome by reducing Ube3a-ATS with antisense oligonucleotides (ASOs).	Astatine	95-98	ubiquitin protein ligase E3A	Homo sapiens	89-94
25470045-6	2015	Here we developed a potential therapeutic intervention for Angelman syndrome by reducing Ube3a-ATS with antisense oligonucleotides (ASOs).	Oligonucleotides	114-130	ubiquitin protein ligase E3A	Homo sapiens	89-94
25355869-10	2015	Identification of UBE3A as a self-antigen recognized by CD4bs bNAbs offers a mechanism for the rarity of this bNAb class.	bnab	62-66	ubiquitin protein ligase E3A	Homo sapiens	18-23