PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 2481466-8 1989 These observations indicate that NPY and GAL are distributed differently in LC neurons from noradrenaline and DBH. Norepinephrine 92-105 galanin and GMAP prepropeptide Homo sapiens 41-44 2900265-3 1988 The antibody was first acylated with a heterobifunctional agent N-(gamma-maleimidobutyryloxy)succinimide (GMBS) to introduce the maleimide groups into the molecule; excess reagent was removed by gel filtration and then the activated antibodies were crosslinked to the thiol groups of Gal. N-(gamma-maleimidobutyryloxy)succinimide 106-110 galanin and GMAP prepropeptide Homo sapiens 284-287 2900265-4 1988 The conjugates were partially purified of free Gal by DEAE-Toyopearl column chromatography with an increasing linear concentration of NaCl. 2-diethylaminoethanol 54-58 galanin and GMAP prepropeptide Homo sapiens 47-50 2900265-4 1988 The conjugates were partially purified of free Gal by DEAE-Toyopearl column chromatography with an increasing linear concentration of NaCl. Sodium Chloride 134-138 galanin and GMAP prepropeptide Homo sapiens 47-50 2446889-1 1987 Galanin (GAL) produced a concentration (0.3-100 nM)-related inhibition of the atropine-sensitive component of the contractions induced by field stimulation of detrusor strips from the dome of the human urinary bladder. Atropine 78-86 galanin and GMAP prepropeptide Homo sapiens 0-7 3131437-2 1988 Goat anti-rabbit IgG was used as a prototype and coupled to beta-D-galactosidase (Gal) with a new heterobifunctional cross-linking agent N-[beta-(4-diazophenyl)ethyl]maleimide (DPEM). N-(beta-(4-diazophenyl)ethyl)maleimide 137-175 galanin and GMAP prepropeptide Homo sapiens 82-85 3131437-2 1988 Goat anti-rabbit IgG was used as a prototype and coupled to beta-D-galactosidase (Gal) with a new heterobifunctional cross-linking agent N-[beta-(4-diazophenyl)ethyl]maleimide (DPEM). N-(beta-(4-diazophenyl)ethyl)maleimide 177-181 galanin and GMAP prepropeptide Homo sapiens 82-85 3131437-3 1988 The antibody was first azo-coupled with DPEM to introduce the maleimide groups into the molecule; excess reagent was removed by gel filtration and then the activated antibodies were crosslinked to the thiol groups of Gal. Sulfhydryl Compounds 201-206 galanin and GMAP prepropeptide Homo sapiens 217-220 3128350-3 1988 Under our conditions, CHO-modified vWF preparations contained less than 5% of the initial sialic acid ([Neu]-ase-vWF) and less than 45% ([Neu-Gal]-ase-vWF) or 21% ([Neu-Gal-eF]-ase-vWF) of the D-galactose. cho 22-25 galanin and GMAP prepropeptide Homo sapiens 142-145 3128350-3 1988 Under our conditions, CHO-modified vWF preparations contained less than 5% of the initial sialic acid ([Neu]-ase-vWF) and less than 45% ([Neu-Gal]-ase-vWF) or 21% ([Neu-Gal-eF]-ase-vWF) of the D-galactose. cho 22-25 galanin and GMAP prepropeptide Homo sapiens 169-172 3128350-6 1988 Platelet adhesion to various matrices increased after removal of the terminal sialic acid ([Neu]-ase-vWF) and approximately 45% of the D-galactose ([Neu-Gal]-ase-vWF), but returned to normal values when greater than 70% of the total carbohydrate had been removed by endoglycosidase F [Neu-Gal-ef]-ase-vWF). Galactose 135-146 galanin and GMAP prepropeptide Homo sapiens 153-156 2446889-1 1987 Galanin (GAL) produced a concentration (0.3-100 nM)-related inhibition of the atropine-sensitive component of the contractions induced by field stimulation of detrusor strips from the dome of the human urinary bladder. Atropine 78-86 galanin and GMAP prepropeptide Homo sapiens 9-12 2446889-3 1987 The effect of GAL was prevented by atropine (1 microM) and was not seen when the strips were stimulated with a cholinomimetic or KCl. Atropine 35-43 galanin and GMAP prepropeptide Homo sapiens 14-17 6786888-13 1981 The structure of the N-glycosidically-linked chain was NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 6)[NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 3)]Man(beta 1 leads to 4)GlcNAc(beta 1 leads to 4)[Fuc alpha 1 leads to 6]GlcNAc leads to Asn. Nitrogen 21-22 galanin and GMAP prepropeptide Homo sapiens 61-115 4054834-1 1985 Urinary excretion of 5-hydroxylysine (Hyl) and its two glycosides, a monoglycoside (Gal-Hyl) and a diglycoside (Glc-Gal-Hyl), and the ratio of the diglycoside to monoglycoside have been studied in 30 patients with Turner"s syndrome and in 38 healthy controls. diglycoside 99-110 galanin and GMAP prepropeptide Homo sapiens 116-119 6517319-2 1984 The carbohydrate residues (Glc-Gal and Gal) released were separated from the modified protein or peptide by gel chromatography and were assayed by gas-liquid chromatography of their trimethylsilyl derivatives. Carbohydrates 4-16 galanin and GMAP prepropeptide Homo sapiens 27-42 6361538-7 1983 Fru, Gal, Ara, Xyl, Man, Lac and Suc also had the ability to form mutagens in the browning reactions with amino acids. Lactose 25-28 galanin and GMAP prepropeptide Homo sapiens 5-8 6786888-13 1981 The structure of the N-glycosidically-linked chain was NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 6)[NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 3)]Man(beta 1 leads to 4)GlcNAc(beta 1 leads to 4)[Fuc alpha 1 leads to 6]GlcNAc leads to Asn. Nitrogen 21-22 galanin and GMAP prepropeptide Homo sapiens 157-211 6786888-13 1981 The structure of the N-glycosidically-linked chain was NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 6)[NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 3)]Man(beta 1 leads to 4)GlcNAc(beta 1 leads to 4)[Fuc alpha 1 leads to 6]GlcNAc leads to Asn. N-Acetylneuraminic Acid 55-60 galanin and GMAP prepropeptide Homo sapiens 61-115 6786888-13 1981 The structure of the N-glycosidically-linked chain was NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 6)[NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 3)]Man(beta 1 leads to 4)GlcNAc(beta 1 leads to 4)[Fuc alpha 1 leads to 6]GlcNAc leads to Asn. N-Acetylneuraminic Acid 55-60 galanin and GMAP prepropeptide Homo sapiens 157-211 6786888-13 1981 The structure of the N-glycosidically-linked chain was NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 6)[NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 3)]Man(beta 1 leads to 4)GlcNAc(beta 1 leads to 4)[Fuc alpha 1 leads to 6]GlcNAc leads to Asn. N-Acetylneuraminic Acid 151-156 galanin and GMAP prepropeptide Homo sapiens 61-115 6786888-13 1981 The structure of the N-glycosidically-linked chain was NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 6)[NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 3)]Man(beta 1 leads to 4)GlcNAc(beta 1 leads to 4)[Fuc alpha 1 leads to 6]GlcNAc leads to Asn. 2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose 198-204 galanin and GMAP prepropeptide Homo sapiens 61-115 6786888-13 1981 The structure of the N-glycosidically-linked chain was NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 6)[NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 3)]Man(beta 1 leads to 4)GlcNAc(beta 1 leads to 4)[Fuc alpha 1 leads to 6]GlcNAc leads to Asn. Asparagine 334-337 galanin and GMAP prepropeptide Homo sapiens 61-115 33240814-5 2020 Differential analysis was conducted to the genome expression between two TMB groups using "limma" package, and we identified four hub TMB-related immune genes including CNTFR, CRABP2, GAL, and PAEP. 1,2,4,5-tetramethoxybenzene 73-76 galanin and GMAP prepropeptide Homo sapiens 184-187 6766756-4 1980 Sa antibody activity was inhibited by sialyllactose NeuAc (alpha 2 leads to 3) (alpha 2 leads to 6) Gal (beta, 1 leads to 4) Glc like anti-Gd but in contrast to anti-Pr. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 galanin and GMAP prepropeptide Homo sapiens 80-141 392766-10 1979 The principal sugar of human milk is lactose but 30 or more oligosaccharides, all containing terminal Gal-(beta 1,4)-Glc and ranging from 3--14 saccharide units per molecule are also present. Oligosaccharides 60-76 galanin and GMAP prepropeptide Homo sapiens 102-143 392766-10 1979 The principal sugar of human milk is lactose but 30 or more oligosaccharides, all containing terminal Gal-(beta 1,4)-Glc and ranging from 3--14 saccharide units per molecule are also present. Carbohydrates 65-75 galanin and GMAP prepropeptide Homo sapiens 102-143 827447-3 1976 A general formula for the antigens is: (Fuc)3-4(Gal)n(LlcNAc)n-2(Glc)1(Sphingosine)1(where Fus is fucose, Gal is galactose, GlcNAc is N-acetylglucosamine and Glc is glucose) with values of n ranging from 10-27. Glucose 64-68 galanin and GMAP prepropeptide Homo sapiens 48-51 827447-3 1976 A general formula for the antigens is: (Fuc)3-4(Gal)n(LlcNAc)n-2(Glc)1(Sphingosine)1(where Fus is fucose, Gal is galactose, GlcNAc is N-acetylglucosamine and Glc is glucose) with values of n ranging from 10-27. Sphingosine 71-83 galanin and GMAP prepropeptide Homo sapiens 48-51 827447-3 1976 A general formula for the antigens is: (Fuc)3-4(Gal)n(LlcNAc)n-2(Glc)1(Sphingosine)1(where Fus is fucose, Gal is galactose, GlcNAc is N-acetylglucosamine and Glc is glucose) with values of n ranging from 10-27. Sphingosine 71-83 galanin and GMAP prepropeptide Homo sapiens 106-109 827447-3 1976 A general formula for the antigens is: (Fuc)3-4(Gal)n(LlcNAc)n-2(Glc)1(Sphingosine)1(where Fus is fucose, Gal is galactose, GlcNAc is N-acetylglucosamine and Glc is glucose) with values of n ranging from 10-27. Fucose 98-104 galanin and GMAP prepropeptide Homo sapiens 48-51 827447-3 1976 A general formula for the antigens is: (Fuc)3-4(Gal)n(LlcNAc)n-2(Glc)1(Sphingosine)1(where Fus is fucose, Gal is galactose, GlcNAc is N-acetylglucosamine and Glc is glucose) with values of n ranging from 10-27. Galactose 113-122 galanin and GMAP prepropeptide Homo sapiens 48-51 827447-3 1976 A general formula for the antigens is: (Fuc)3-4(Gal)n(LlcNAc)n-2(Glc)1(Sphingosine)1(where Fus is fucose, Gal is galactose, GlcNAc is N-acetylglucosamine and Glc is glucose) with values of n ranging from 10-27. Galactose 113-122 galanin and GMAP prepropeptide Homo sapiens 106-109 827447-3 1976 A general formula for the antigens is: (Fuc)3-4(Gal)n(LlcNAc)n-2(Glc)1(Sphingosine)1(where Fus is fucose, Gal is galactose, GlcNAc is N-acetylglucosamine and Glc is glucose) with values of n ranging from 10-27. Acetylglucosamine 124-130 galanin and GMAP prepropeptide Homo sapiens 48-51 827447-3 1976 A general formula for the antigens is: (Fuc)3-4(Gal)n(LlcNAc)n-2(Glc)1(Sphingosine)1(where Fus is fucose, Gal is galactose, GlcNAc is N-acetylglucosamine and Glc is glucose) with values of n ranging from 10-27. Acetylglucosamine 134-153 galanin and GMAP prepropeptide Homo sapiens 48-51 827447-3 1976 A general formula for the antigens is: (Fuc)3-4(Gal)n(LlcNAc)n-2(Glc)1(Sphingosine)1(where Fus is fucose, Gal is galactose, GlcNAc is N-acetylglucosamine and Glc is glucose) with values of n ranging from 10-27. Glucose 165-172 galanin and GMAP prepropeptide Homo sapiens 48-51 827447-12 1976 In poly(glycosyl)ceramides isolated from A and A2 erythrocytes the branches are terminated with the following structures GalNAc alpha 1 leads to 3 [Fuc alpha 1 leads to 2] Gal; Fuc alpha 1 leads to 2 Gal and Gal (presumably Gal beta 1 leads to 4 GlcNAc). poly(glycosyl)ceramides 3-26 galanin and GMAP prepropeptide Homo sapiens 121-124 827447-12 1976 In poly(glycosyl)ceramides isolated from A and A2 erythrocytes the branches are terminated with the following structures GalNAc alpha 1 leads to 3 [Fuc alpha 1 leads to 2] Gal; Fuc alpha 1 leads to 2 Gal and Gal (presumably Gal beta 1 leads to 4 GlcNAc). poly(glycosyl)ceramides 3-26 galanin and GMAP prepropeptide Homo sapiens 172-175 827447-12 1976 In poly(glycosyl)ceramides isolated from A and A2 erythrocytes the branches are terminated with the following structures GalNAc alpha 1 leads to 3 [Fuc alpha 1 leads to 2] Gal; Fuc alpha 1 leads to 2 Gal and Gal (presumably Gal beta 1 leads to 4 GlcNAc). poly(glycosyl)ceramides 3-26 galanin and GMAP prepropeptide Homo sapiens 172-175 827447-12 1976 In poly(glycosyl)ceramides isolated from A and A2 erythrocytes the branches are terminated with the following structures GalNAc alpha 1 leads to 3 [Fuc alpha 1 leads to 2] Gal; Fuc alpha 1 leads to 2 Gal and Gal (presumably Gal beta 1 leads to 4 GlcNAc). poly(glycosyl)ceramides 3-26 galanin and GMAP prepropeptide Homo sapiens 172-175 827447-12 1976 In poly(glycosyl)ceramides isolated from A and A2 erythrocytes the branches are terminated with the following structures GalNAc alpha 1 leads to 3 [Fuc alpha 1 leads to 2] Gal; Fuc alpha 1 leads to 2 Gal and Gal (presumably Gal beta 1 leads to 4 GlcNAc). N-acetylgalactosaminuronic acid 121-127 galanin and GMAP prepropeptide Homo sapiens 172-175 827447-12 1976 In poly(glycosyl)ceramides isolated from A and A2 erythrocytes the branches are terminated with the following structures GalNAc alpha 1 leads to 3 [Fuc alpha 1 leads to 2] Gal; Fuc alpha 1 leads to 2 Gal and Gal (presumably Gal beta 1 leads to 4 GlcNAc). N-acetylgalactosaminuronic acid 121-127 galanin and GMAP prepropeptide Homo sapiens 172-175 827447-12 1976 In poly(glycosyl)ceramides isolated from A and A2 erythrocytes the branches are terminated with the following structures GalNAc alpha 1 leads to 3 [Fuc alpha 1 leads to 2] Gal; Fuc alpha 1 leads to 2 Gal and Gal (presumably Gal beta 1 leads to 4 GlcNAc). N-acetylgalactosaminuronic acid 121-127 galanin and GMAP prepropeptide Homo sapiens 172-175 827447-12 1976 In poly(glycosyl)ceramides isolated from A and A2 erythrocytes the branches are terminated with the following structures GalNAc alpha 1 leads to 3 [Fuc alpha 1 leads to 2] Gal; Fuc alpha 1 leads to 2 Gal and Gal (presumably Gal beta 1 leads to 4 GlcNAc). Acetylglucosamine 246-252 galanin and GMAP prepropeptide Homo sapiens 121-124 33707345-0 2021 Lupeol ameliorates LPS/D-GalN induced acute hepatic damage by suppressing inflammation and oxidative stress through TGFbeta1-Nrf2 signal pathway. lupeol 0-6 galanin and GMAP prepropeptide Homo sapiens 25-29 32681650-5 2021 Moreover, the immune complexes of SARS-CoV-2 and anti-Gal antibodies could enhance the efficacy of COVID-19 vaccines, live or inactivated, carrying alpha-Gal glycans. alpha-gal glycans 148-165 galanin and GMAP prepropeptide Homo sapiens 54-57 33240814-5 2020 Differential analysis was conducted to the genome expression between two TMB groups using "limma" package, and we identified four hub TMB-related immune genes including CNTFR, CRABP2, GAL, and PAEP. 1,2,4,5-tetramethoxybenzene 134-137 galanin and GMAP prepropeptide Homo sapiens 184-187 32157157-3 2020 Our results revealed that lncRNA NEAT1 was upregulated in cell and animal models of FHF induced by D-galactosamine (D-GalN)/lipopolysaccharide (LPS). Galactosamine 99-114 galanin and GMAP prepropeptide Homo sapiens 118-122 32368008-7 2020 Studies have suggested that GAL enhances the action of selective serotonin reuptake inhibitors (SSRIs) and promotes availability of transcription proteins. Serotonin 65-74 galanin and GMAP prepropeptide Homo sapiens 28-31 32431618-0 2020 Quercetin Attenuates d-GaLN-Induced L02 Cell Damage by Suppressing Oxidative Stress and Mitochondrial Apoptosis via Inhibition of HMGB1. Quercetin 0-9 galanin and GMAP prepropeptide Homo sapiens 23-27 32431618-7 2020 Our results indicated that Que protects L02 cells from d-galactosamine (d-GaLN)-induced cellular damage by reducing intracellular reactive oxygen species (ROS) production and apoptotic responses in the mitochondrial pathway. Galactosamine 55-70 galanin and GMAP prepropeptide Homo sapiens 74-78 32431618-7 2020 Our results indicated that Que protects L02 cells from d-galactosamine (d-GaLN)-induced cellular damage by reducing intracellular reactive oxygen species (ROS) production and apoptotic responses in the mitochondrial pathway. Reactive Oxygen Species 130-153 galanin and GMAP prepropeptide Homo sapiens 74-78 32431618-7 2020 Our results indicated that Que protects L02 cells from d-galactosamine (d-GaLN)-induced cellular damage by reducing intracellular reactive oxygen species (ROS) production and apoptotic responses in the mitochondrial pathway. Reactive Oxygen Species 155-158 galanin and GMAP prepropeptide Homo sapiens 74-78 32431618-12 2020 Taken together, these results indicate that Que significantly improves d-GaLN-induced cellular damage by inhibiting oxidative stress and mitochondrial apoptosis via inhibiting HMGB1. Quercetin 44-47 galanin and GMAP prepropeptide Homo sapiens 73-77 31151328-2 2019 Here, Chit was conjugated with gallic acid (Chit-Gal) to decrease the formation of CaOx crystal. Gallic Acid 31-42 galanin and GMAP prepropeptide Homo sapiens 49-52 30838766-6 2019 KEY RESULTS: Both doses of BPA studied changed the number of the enteric neurons immunoreactive to SP, VIP, GAL, VAChT, and CART, and the intensity of fluctuations depended on the BPA dose and on the type of the enteric plexus. bisphenol A 27-30 galanin and GMAP prepropeptide Homo sapiens 108-111 31151328-2 2019 Here, Chit was conjugated with gallic acid (Chit-Gal) to decrease the formation of CaOx crystal. caox crystal 83-95 galanin and GMAP prepropeptide Homo sapiens 49-52 30552777-5 2019 RESULTS: Chiisanoside pretreatment evidently reduced the activities of alanine transaminase (ALT) and aspartate transaminase (AST) in the changes induced by LPS/D-GalN, and these histopathological changes induced by LPS/GalN were significantly weakened. chiisanoside 9-21 galanin and GMAP prepropeptide Homo sapiens 163-167 30552777-0 2019 Hepatoprotective effect of chiisanoside from Acanthopanax sessiliflorus against LPS/D-GalN-induced acute liver injury by inhibiting NF-kappaB and activating Nrf2/HO-1 signaling pathways. chiisanoside 27-39 galanin and GMAP prepropeptide Homo sapiens 86-90 30552777-5 2019 RESULTS: Chiisanoside pretreatment evidently reduced the activities of alanine transaminase (ALT) and aspartate transaminase (AST) in the changes induced by LPS/D-GalN, and these histopathological changes induced by LPS/GalN were significantly weakened. chiisanoside 9-21 galanin and GMAP prepropeptide Homo sapiens 220-224 30552777-4 2019 Combined use of lipopolysaccharide and d-galactosamine (LPS/D-GalN) can induce acute liver failure in human beings, and there are no reports on the protective effect of CSS against LPS/D-GalN-induced acute liver injury in mice. Galactosamine 39-54 galanin and GMAP prepropeptide Homo sapiens 62-66 30552777-6 2019 Catalase (CAT), glutathione (GSH), and superoxide dismutase (SOD) activities increased, and malondialdehyde (MDA) activity decreased after CSS treatment compared with LPS/D-GalN treatment. chiisanoside 139-142 galanin and GMAP prepropeptide Homo sapiens 173-177 31048987-2 2019 In this study its beneficial dietary effect against liver injuries caused by d-galactosamine (d-GalN) was studied ensuring safety to human health using animal model. Galactosamine 77-92 galanin and GMAP prepropeptide Homo sapiens 96-100 29210146-9 2019 These results may give the basis for the development of novel therapeutics strategies using GAL(1-15) analogues for the treatment of alcohol use disorders in humans. Alcohols 133-140 galanin and GMAP prepropeptide Homo sapiens 92-95 30131588-5 2019 Ex vivo experiments with patient-derived blood cells (AKT phosphorylation), as well as studies in recombinant cell lines expressing the human GALR2 (calcium mobilization and NFAT mediated gene transcription), showed that galanin (GAL) was unable to stimulate cell signaling in cells expressing the variant GALR2 allele. Calcium 149-156 galanin and GMAP prepropeptide Homo sapiens 221-228 30131588-5 2019 Ex vivo experiments with patient-derived blood cells (AKT phosphorylation), as well as studies in recombinant cell lines expressing the human GALR2 (calcium mobilization and NFAT mediated gene transcription), showed that galanin (GAL) was unable to stimulate cell signaling in cells expressing the variant GALR2 allele. Calcium 149-156 galanin and GMAP prepropeptide Homo sapiens 142-145 30593944-3 2019 ScGalK displayed a broad substrate tolerance, with activity towards Gal, GalN, Gal3D, GalNAc, Man and L-Ara. cyclohexenoesculetin-beta-galactoside 2-5 galanin and GMAP prepropeptide Homo sapiens 73-77 30257876-3 2019 On-chip glycan modification and probing (on-chip gmap) uses sequential and parallel rounds of exoglycosidase cleavage and lectin profiling of microspots of proteins, together with algorithms that incorporate glycan-array analyses and information from mass spectrometry, when available, to computationally interpret the data. Polysaccharides 8-14 galanin and GMAP prepropeptide Homo sapiens 49-53 30257876-3 2019 On-chip glycan modification and probing (on-chip gmap) uses sequential and parallel rounds of exoglycosidase cleavage and lectin profiling of microspots of proteins, together with algorithms that incorporate glycan-array analyses and information from mass spectrometry, when available, to computationally interpret the data. Polysaccharides 208-214 galanin and GMAP prepropeptide Homo sapiens 49-53 30257876-4 2019 In tests on control proteins with simple or complex glycosylation, on-chip gmap accurately characterized the relative proportions of core types and terminal features of glycans. Polysaccharides 169-176 galanin and GMAP prepropeptide Homo sapiens 75-79 30257876-7 2019 An alternative use of on-chip gmap was to complement the mass spectrometry analysis of detached glycans by specifying the isomers that comprise the glycans identified by mass spectrometry. Polysaccharides 96-103 galanin and GMAP prepropeptide Homo sapiens 30-34 30257876-7 2019 An alternative use of on-chip gmap was to complement the mass spectrometry analysis of detached glycans by specifying the isomers that comprise the glycans identified by mass spectrometry. Polysaccharides 148-155 galanin and GMAP prepropeptide Homo sapiens 30-34 30132515-3 2018 In the present study, the protective effects of hPH against D-galactosamine (D-GalN)- and lipopolysaccharide (LPS)-induced hepatocyte apoptosis were investigated in vivo. hph 48-51 galanin and GMAP prepropeptide Homo sapiens 79-83 29298996-6 2018 Four nominally significant trans-eQTLs were predicted to regulate three candidate genes (SELL, MTF2, and GAL), the expression of which was significantly reduced in LCLs following zileuton treatment. zileuton 179-187 galanin and GMAP prepropeptide Homo sapiens 105-108 29603325-7 2018 Pdk4-/- livers were sensitized to Jo2 and D-(+)-Galactosamine /Lipopolysaccharide (GalN/LPS)-mediated apoptotic injury which was prevented by the inhibition of p65 or TNFR1. Galactosamine 42-61 galanin and GMAP prepropeptide Homo sapiens 83-87 29888781-13 2018 Moreover, BPA exposure caused an increased presence of sympathetic nerve fibers in these two experimental groups, which were co-localized with CART and GAL up to 65.9%/173.2% and 147.4%/126.3%, respectively. bisphenol A 10-13 galanin and GMAP prepropeptide Homo sapiens 152-155 29932649-9 2018 Moreover, we showed that pLys-4RepCT silk coatings bind mucins through electrostatic interactions, while hGal3-4RepCT silk coatings bind mucins through specific glycan-protein interactions. Polysaccharides 161-167 galanin and GMAP prepropeptide Homo sapiens 105-109 29628491-3 2018 In this study, two effective cryogenic methodologies were successfully reported to alter the physicochemical properties of a precipitate of an octyl beta-D-galactoside (Oct-Gal)-water system. octyl galactopyranoside 143-167 galanin and GMAP prepropeptide Homo sapiens 173-176 29628491-3 2018 In this study, two effective cryogenic methodologies were successfully reported to alter the physicochemical properties of a precipitate of an octyl beta-D-galactoside (Oct-Gal)-water system. Water 178-183 galanin and GMAP prepropeptide Homo sapiens 173-176 29888781-17 2018 The increase in CART and GAL were excep-tionally high even at low BPA doses. bisphenol A 66-69 galanin and GMAP prepropeptide Homo sapiens 25-28 28946644-3 2017 Glycyrrhetinic acid (GA) liposomes containing Man-DLD-Chol (Man-DLD-Chol-GA-Lp) were prepared by the film-dispersion method. Glycyrrhetinic Acid 0-19 galanin and GMAP prepropeptide Homo sapiens 73-78 29254224-1 2017 In this study, novel glycyrrhetinic acid (GA) liposomes modified with a liver-targeting galactosylated derivative ligand (Gal) were prepared using a film-dispersion method. Glycyrrhetinic Acid 21-40 galanin and GMAP prepropeptide Homo sapiens 122-125 29254224-1 2017 In this study, novel glycyrrhetinic acid (GA) liposomes modified with a liver-targeting galactosylated derivative ligand (Gal) were prepared using a film-dispersion method. Glycyrrhetinic Acid 42-44 galanin and GMAP prepropeptide Homo sapiens 122-125 28946644-3 2017 Glycyrrhetinic acid (GA) liposomes containing Man-DLD-Chol (Man-DLD-Chol-GA-Lp) were prepared by the film-dispersion method. Glycyrrhetinic Acid 21-23 galanin and GMAP prepropeptide Homo sapiens 73-78 27914762-13 2017 GAL-IR was also detected in choroidal melanocytes, as identified by the presence of intracellular melanin-granules, as well as in cells lacking melanin-granules, most likely representing macrophages. Melanins 98-105 galanin and GMAP prepropeptide Homo sapiens 0-3 27914762-13 2017 GAL-IR was also detected in choroidal melanocytes, as identified by the presence of intracellular melanin-granules, as well as in cells lacking melanin-granules, most likely representing macrophages. Melanins 144-151 galanin and GMAP prepropeptide Homo sapiens 0-3 27809484-10 2016 The on-chip glycan modification and probing (on-chip GMAP) method provides a platform for analyzing protein glycosylation in clinical specimens and could complement the existing toolkit for studying glycosylation in disease. Polysaccharides 12-18 galanin and GMAP prepropeptide Homo sapiens 53-57 28535934-4 2017 Since GlcN is present only in KS we developed a method that separates GlcN from GalN, the principal hydrolytic product of CS, and then we validated it in order to quantify GlcN. Chondroitin Sulfates 122-124 galanin and GMAP prepropeptide Homo sapiens 80-84 28584529-0 2017 hTERT-Immortalized Bone Mesenchymal Stromal Cells Expressing Rat Galanin via a Single Tetracycline-Inducible Lentivirus System. Tetracycline 86-98 galanin and GMAP prepropeptide Homo sapiens 65-72 27474259-0 2016 Circulating galanin and galanin like peptide concentrations are correlated with increased triglyceride concentration in obese patients. Triglycerides 90-102 galanin and GMAP prepropeptide Homo sapiens 12-19 27474259-0 2016 Circulating galanin and galanin like peptide concentrations are correlated with increased triglyceride concentration in obese patients. Triglycerides 90-102 galanin and GMAP prepropeptide Homo sapiens 24-31 27474259-7 2016 In addition, the positive correlations were found between: GAL and triglyceride (TG) concentrations (r=0.636; P<0.001), GALP and TG concentrations (r=0.362; P=0.020) in obese subjects. Triglycerides 67-79 galanin and GMAP prepropeptide Homo sapiens 59-62 27474259-7 2016 In addition, the positive correlations were found between: GAL and triglyceride (TG) concentrations (r=0.636; P<0.001), GALP and TG concentrations (r=0.362; P=0.020) in obese subjects. Triglycerides 81-83 galanin and GMAP prepropeptide Homo sapiens 59-62 26917098-8 2016 Acetylsalicylic acid supplementation caused a considerable increase in the expression of all active substances studied within both left and right NG and the percentage of neurons positive to particular substances fluctuated from 47.2 +- 3.6% (GAL-LI neurons in the right NG) to 67.2 +- 2.0% (cells immunoreactive to SP in the left NG). Aspirin 0-20 galanin and GMAP prepropeptide Homo sapiens 243-246 27121264-3 2016 As GAL and its receptors are expressed in human and murine skin and GAL expression is increased in oxazolone-induced contact allergy, it could play a role in dermatitis. Oxazolone 99-108 galanin and GMAP prepropeptide Homo sapiens 3-6 27550417-2 2016 The objective of this study was to investigate the serum levels of GAL during an oral glucose tolerance test (OGTT) in lean and obese young men. Glucose 86-93 galanin and GMAP prepropeptide Homo sapiens 67-70 27550417-8 2016 Serum GAL levels were positively correlated with BMI, total fat, visceral fat, HOMA-IR, total cholesterol, triglycerides and Leptin. Cholesterol 94-105 galanin and GMAP prepropeptide Homo sapiens 6-9 27550417-8 2016 Serum GAL levels were positively correlated with BMI, total fat, visceral fat, HOMA-IR, total cholesterol, triglycerides and Leptin. Triglycerides 107-120 galanin and GMAP prepropeptide Homo sapiens 6-9 26747425-4 2016 Recombinant human galectins (hGal)-1, -3, -4, -7, -8 and -9 bound selectively to glycans, with each galectin recognizing a relatively unique binding motif; by contrast hGal-2 did not recognize HMGs, but did bind to the human blood group A Type 2 determinants on other microarrays. Polysaccharides 81-88 galanin and GMAP prepropeptide Homo sapiens 29-33 26747425-5 2016 Unlike other galectins, hGal-7 preferentially bound to glycans expressing a terminal Type 1 (Galbeta1-3GlcNAc) sequence, a motif that had eluded detection on non-HMG glycan microarrays. Polysaccharides 55-62 galanin and GMAP prepropeptide Homo sapiens 24-28 26747425-5 2016 Unlike other galectins, hGal-7 preferentially bound to glycans expressing a terminal Type 1 (Galbeta1-3GlcNAc) sequence, a motif that had eluded detection on non-HMG glycan microarrays. Galbeta1,3GlcNAc 93-109 galanin and GMAP prepropeptide Homo sapiens 24-28 26747425-5 2016 Unlike other galectins, hGal-7 preferentially bound to glycans expressing a terminal Type 1 (Galbeta1-3GlcNAc) sequence, a motif that had eluded detection on non-HMG glycan microarrays. Polysaccharides 55-61 galanin and GMAP prepropeptide Homo sapiens 24-28 27352343-10 2015 Levetiracetam can improve life quality of patients with refractory epilepsy, decrease NPY and GAL in plasma and cerebrospinal fluid, serum PON1 and ARE activities, and serum levels of ox-LDL, hs-CRP, and S100B. Levetiracetam 0-13 galanin and GMAP prepropeptide Homo sapiens 94-97 26811880-5 2016 As such, HNPs containing TNF-alpha siRNA afforded effective systemic TNF-alpha knockdown following systemic administration at a low dose of 50 mug of siRNA/kg and thus demonstrated a potent anti-inflammatory effect to rescue animals from LPS/d-GalN-induced hepatic sepsis. Deuterium 46-47 galanin and GMAP prepropeptide Homo sapiens 244-248 26278168-4 2015 The %GalN test was sensitive to the presence of NS-OSCS in heparin. Heparin 59-66 galanin and GMAP prepropeptide Homo sapiens 5-9 26565961-4 2015 The results showed that GAL in the DMH and glutamate in the DRt lead to behavioural hyperalgesia in both SHAM and ARTH animals, which is accompanied particularly by an increase in heat-evoked responses of wide-dynamic range neurons, a group of nociceptive SDH neurones. Dimenhydrinate 35-38 galanin and GMAP prepropeptide Homo sapiens 24-27 26565961-4 2015 The results showed that GAL in the DMH and glutamate in the DRt lead to behavioural hyperalgesia in both SHAM and ARTH animals, which is accompanied particularly by an increase in heat-evoked responses of wide-dynamic range neurons, a group of nociceptive SDH neurones. sdh 256-259 galanin and GMAP prepropeptide Homo sapiens 24-27 26565961-5 2015 Facilitation of pain behaviour induced by GAL in the DMH was reversed by lidocaine in the DRt and by ondansetron, a 5HT3R antagonist, in the spinal cord. Dimenhydrinate 53-56 galanin and GMAP prepropeptide Homo sapiens 42-45 26565961-5 2015 Facilitation of pain behaviour induced by GAL in the DMH was reversed by lidocaine in the DRt and by ondansetron, a 5HT3R antagonist, in the spinal cord. Lidocaine 73-82 galanin and GMAP prepropeptide Homo sapiens 42-45 26565961-5 2015 Facilitation of pain behaviour induced by GAL in the DMH was reversed by lidocaine in the DRt and by ondansetron, a 5HT3R antagonist, in the spinal cord. Ondansetron 101-112 galanin and GMAP prepropeptide Homo sapiens 42-45 26565961-8 2015 Our data demonstrate that GAL in the DMH activates two independent descending facilitatory pathways: (i) one relays in the DRt and (ii) the other one involves 5-HT neurones acting on spinal 5HT3Rs. Dimenhydrinate 37-40 galanin and GMAP prepropeptide Homo sapiens 26-29 25834926-3 2015 Results showed that the total soluble sugar contents of SAP composed of Man, GlcN, Rha, GalN, GlcUA, Glc, Gal, Xyl and Fuc were more than 85% estimated by the phenol-sulfuric acid assay. Sugars 38-43 galanin and GMAP prepropeptide Homo sapiens 88-92 26211586-5 2015 These results were confirmed by histopathology examination which showed a severe degeneration, haemorrhages, widened sinusoids and focal leukocyte infiltration in D-GALN/LPS treatment and these features were alleviated with CeO2 administration. ceric oxide 224-228 galanin and GMAP prepropeptide Homo sapiens 165-169 26050803-0 2015 Immunohistochemical evidence of the co-localisation of cocaine and amphetamine regulatory peptide with neuronal isoform of nitric oxide synthase, vasoactive intestinal peptide and galanin within the circular muscle layer of the human caecum. Amphetamine 67-78 galanin and GMAP prepropeptide Homo sapiens 180-187 25943027-0 2015 Salvianolic acid A attenuates TNF-alpha- and D-GalN-induced ER stress-mediated and mitochondrial-dependent apoptosis by modulating Bax/Bcl-2 ratio and calcium release in hepatocyte LO2 cells. salvianolic acid A 0-18 galanin and GMAP prepropeptide Homo sapiens 47-51 25943027-3 2015 Here, the study showed that Sal A had antiapoptotic effects on the TNF-alpha/D-GalN-treated LO2 cells. salvianolic acid 28-33 galanin and GMAP prepropeptide Homo sapiens 79-83 25943027-8 2015 In summary, Sal A attenuates TNF-alpha- and D-GalN-induced both ER stress and mitochondrial-dependent apoptosis by suppression of Bax/Bcl-2 ratio and prevention of calcium release, which support the notion that Sal A could be developed into a novel hepatic protectant. salvianolic acid 12-17 galanin and GMAP prepropeptide Homo sapiens 46-50 26211586-0 2015 Cerium oxide nanoparticles alleviate oxidative stress and decreases Nrf-2/HO-1 in D-GALN/LPS induced hepatotoxicity. ceric oxide 0-12 galanin and GMAP prepropeptide Homo sapiens 84-88 26211586-1 2015 Translocation of the master regulator of antioxidant-response element-driven antioxidant gene, nuclear factor erythroid 2 (Nrf-2) from the cytoplasm into the nucleus and triggering the transcription of hemoxygenase-1 (HO-1) to counteract the oxidative stress is a key feature in D-galactoseamine and lipopolysaccharide (D-GALN/LPS) induced hepatotoxicity. d-galactoseamine 279-295 galanin and GMAP prepropeptide Homo sapiens 322-326 26052559-1 2015 BACKGROUND: Gal-32 is a Chinese hamster lung cell nuclear mutant that is unable to grow in galactose due to a defect in mitochondrial protein synthesis. Galactose 91-100 galanin and GMAP prepropeptide Homo sapiens 12-15 26052559-8 2015 CONCLUSION: These data demonstrate the isolation of two pCV108-transformant recombinant clones containing a human gene that complements the Chinese hamster Gal-32 mutation and restores galactose metabolism. Galactose 185-194 galanin and GMAP prepropeptide Homo sapiens 156-159 25449276-6 2014 More importantly, we found that autophagy was induced to increase in LPS/D-GalN-induced acute liver injury, and pretreatment with wortmannin could effectively inhibit increased autophagy in acute liver injury. Wortmannin 130-140 galanin and GMAP prepropeptide Homo sapiens 75-79 25449276-7 2014 In conclusion, these results indicate that wortmannin plays a protective role in LPS/D-GalN induced hepatocytotoxity maybe by inhibiting autophagy and could be acted as a target for the treatment of acute liver injury. Wortmannin 43-53 galanin and GMAP prepropeptide Homo sapiens 87-91 24706871-1 2014 Galanin is a stress-inducible neuropeptide and cotransmitter in serotonin and norepinephrine neurons with a possible role in stress-related disorders. Serotonin 64-73 galanin and GMAP prepropeptide Homo sapiens 0-7 24993825-5 2014 The hydrophilic core oligosaccharide was found to be a complex hexasaccharide with two mannose (Man) and one each of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo), Gal, GalN, and l-rhamnose residues. Oligosaccharides 21-36 galanin and GMAP prepropeptide Homo sapiens 160-163 24993825-5 2014 The hydrophilic core oligosaccharide was found to be a complex hexasaccharide with two mannose (Man) and one each of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo), Gal, GalN, and l-rhamnose residues. Oligosaccharides 21-36 galanin and GMAP prepropeptide Homo sapiens 165-169 24993825-5 2014 The hydrophilic core oligosaccharide was found to be a complex hexasaccharide with two mannose (Man) and one each of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo), Gal, GalN, and l-rhamnose residues. hexasaccharide 63-77 galanin and GMAP prepropeptide Homo sapiens 160-163 24993825-5 2014 The hydrophilic core oligosaccharide was found to be a complex hexasaccharide with two mannose (Man) and one each of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo), Gal, GalN, and l-rhamnose residues. hexasaccharide 63-77 galanin and GMAP prepropeptide Homo sapiens 165-169 25003818-3 2014 H-Phosphonate and phosphoramidite approaches have been explored for the coupling of 4,6-DTBS-2-azido-protected GalN lactol and peracetylated spacer-equipped reducing betaGlcN(1 6)GlcN disaccharide via phosphodiester linkage. h-phosphonate 0-13 galanin and GMAP prepropeptide Homo sapiens 111-115 25003818-3 2014 H-Phosphonate and phosphoramidite approaches have been explored for the coupling of 4,6-DTBS-2-azido-protected GalN lactol and peracetylated spacer-equipped reducing betaGlcN(1 6)GlcN disaccharide via phosphodiester linkage. phosphoramidite 18-33 galanin and GMAP prepropeptide Homo sapiens 111-115 25003818-3 2014 H-Phosphonate and phosphoramidite approaches have been explored for the coupling of 4,6-DTBS-2-azido-protected GalN lactol and peracetylated spacer-equipped reducing betaGlcN(1 6)GlcN disaccharide via phosphodiester linkage. 4,6-dtbs 84-92 galanin and GMAP prepropeptide Homo sapiens 111-115 25003818-3 2014 H-Phosphonate and phosphoramidite approaches have been explored for the coupling of 4,6-DTBS-2-azido-protected GalN lactol and peracetylated spacer-equipped reducing betaGlcN(1 6)GlcN disaccharide via phosphodiester linkage. betaglcn 166-174 galanin and GMAP prepropeptide Homo sapiens 111-115 25003818-3 2014 H-Phosphonate and phosphoramidite approaches have been explored for the coupling of 4,6-DTBS-2-azido-protected GalN lactol and peracetylated spacer-equipped reducing betaGlcN(1 6)GlcN disaccharide via phosphodiester linkage. glcn disaccharide 179-196 galanin and GMAP prepropeptide Homo sapiens 111-115 24706871-1 2014 Galanin is a stress-inducible neuropeptide and cotransmitter in serotonin and norepinephrine neurons with a possible role in stress-related disorders. Norepinephrine 78-92 galanin and GMAP prepropeptide Homo sapiens 0-7 24759764-5 2014 In the study, the anti-hepatitis B property of cichoric acid was evaluated by the D-galactosamine (D-GalN)-induced normal human HL-7702 hepatocyte injury model, the duck hepatitis B virus (DHBV)-infected duck fetal hepatocytes and the HBV-transfected cell line HepG2.2.15 cells, respectively. chicoric acid 47-60 galanin and GMAP prepropeptide Homo sapiens 101-105 24550397-7 2014 Activated platelets can also supply the sialic acid donor to sialylate the synthetic acceptor, Gal(beta1,4)GlcNAcalpha-o-benzyl, with the product Sia(alpha2,6)Gal(beta1,4)GlcNAcalpha-o-benzyl structurally confirmed by LC/MS. N-Acetylneuraminic Acid 40-51 galanin and GMAP prepropeptide Homo sapiens 95-118 24550397-7 2014 Activated platelets can also supply the sialic acid donor to sialylate the synthetic acceptor, Gal(beta1,4)GlcNAcalpha-o-benzyl, with the product Sia(alpha2,6)Gal(beta1,4)GlcNAcalpha-o-benzyl structurally confirmed by LC/MS. N-Acetylneuraminic Acid 40-51 galanin and GMAP prepropeptide Homo sapiens 159-182 24759764-6 2014 The results showed that cichoric acid attenuated significantly D-GalN-induced HL-7702 hepatocyte injury at 10-100 microg/mL and produced a maximum protection rate of 56.26%. chicoric acid 24-37 galanin and GMAP prepropeptide Homo sapiens 65-69 24490570-3 2013 It found that TNF-alpha and D-GalN could obviously inhibit hepatocyte proliferation, induce cell apoptosis, and significantly increase free calcium ions in cytoplasms, as well as protein expressions of ERS apoptosis-related signal molecules phosphorylated PERK, phosphorylated elF2alpha, cleaved Caspase-12, GRP78 and CHOP. Calcium 140-147 galanin and GMAP prepropeptide Homo sapiens 30-34 24817287-1 2014 OBJECTIVE: To compare the effects of the pretreatment and treatment with recombinant human interleukin-11 (rhIL-11) on acute liver failure induced by D-galactosamine (D-GalN). Galactosamine 150-165 galanin and GMAP prepropeptide Homo sapiens 169-173 23206306-2 2012 METHODS: A contact-independent model of aberrant hepatic microenvironment was established by co-culturing BM-MSCs with D-galactosamine (D-GalN)-injured human L02 hepatic cells using a transwell assay platform. Galactosamine 119-134 galanin and GMAP prepropeptide Homo sapiens 138-142 23864198-3 2013 This study attempted to investigate the hepatoprotective effect and possible mechanism of beta-NGF on D-galactosamine (D-GalN)-injured human liver L-02 cell lines. Galactosamine 102-117 galanin and GMAP prepropeptide Homo sapiens 121-125 23499803-0 2013 Different responses of galanin and calcitonin gene-related peptide to capsaicin stimulation on dorsal root ganglion neurons in vitro. Capsaicin 70-79 galanin and GMAP prepropeptide Homo sapiens 23-30 23259957-0 2013 Incorporation of monodisperse oligoethyleneglycol amino acids into anticonvulsant analogues of galanin and neuropeptide y provides peripherally acting analgesics. monodisperse oligoethyleneglycol amino acids 17-61 galanin and GMAP prepropeptide Homo sapiens 95-102 23259957-2 2013 Our previous work showed that the combination of lipidization and cationization applied to anticonvulsant neuropeptides galanin (GAL) and neuropeptide Y (NPY) improved their penetration across the blood-brain barrier yielding potent antiepileptic lead compounds, such as Gal-B2 (NAX 5055) or NPY-B2. Carbonic Acid 279-282 galanin and GMAP prepropeptide Homo sapiens 120-127 23259957-2 2013 Our previous work showed that the combination of lipidization and cationization applied to anticonvulsant neuropeptides galanin (GAL) and neuropeptide Y (NPY) improved their penetration across the blood-brain barrier yielding potent antiepileptic lead compounds, such as Gal-B2 (NAX 5055) or NPY-B2. Carbonic Acid 279-282 galanin and GMAP prepropeptide Homo sapiens 129-132 23259957-3 2013 To dissect peripheral and central actions of anticonvulsant neuropeptides, we rationally designed, synthesized and characterized GAL and NPY analogues containing monodisperse (discrete) oligoethyleneglycol-lysine (dPEG-Lys). oligoethyleneglycol-lysine 186-212 galanin and GMAP prepropeptide Homo sapiens 129-132 23259957-4 2013 The dPEGylated analogues Gal-B2-dPEG(24), Gal-R2-dPEG(24) and NPY-dPEG(24) displayed analgesic activities following systemic administration, while avoiding penetration into the brain. dpeg 4-8 galanin and GMAP prepropeptide Homo sapiens 25-28 23259957-4 2013 The dPEGylated analogues Gal-B2-dPEG(24), Gal-R2-dPEG(24) and NPY-dPEG(24) displayed analgesic activities following systemic administration, while avoiding penetration into the brain. dpeg 4-8 galanin and GMAP prepropeptide Homo sapiens 42-45 23259957-5 2013 Gal-B2-dPEG(24) was synthesized by a stepwise deprotection of orthogonal 4-methoxytrityl and allyloxycarbonyl groups, and subsequent on-resin conjugations of dPEG(24) and palmitic acids, respectively. -dpeg 6-11 galanin and GMAP prepropeptide Homo sapiens 0-3 23259957-5 2013 Gal-B2-dPEG(24) was synthesized by a stepwise deprotection of orthogonal 4-methoxytrityl and allyloxycarbonyl groups, and subsequent on-resin conjugations of dPEG(24) and palmitic acids, respectively. dpeg 7-11 galanin and GMAP prepropeptide Homo sapiens 0-3 23259957-5 2013 Gal-B2-dPEG(24) was synthesized by a stepwise deprotection of orthogonal 4-methoxytrityl and allyloxycarbonyl groups, and subsequent on-resin conjugations of dPEG(24) and palmitic acids, respectively. Palmitic Acids 171-185 galanin and GMAP prepropeptide Homo sapiens 0-3 20645434-3 2010 Our recent studies with GAL analogs suggested that an introduction of lipoamino acids in the context of oligo-Lys residues (lipidization-cationization motif) significantly increases their penetration into the brain, yielding potent antiepileptic compounds. lipoamino acids 70-85 galanin and GMAP prepropeptide Homo sapiens 24-27 22742906-2 2012 With studies in adult animals showing the orexigenic peptides, enkephalin (ENK), galanin (GAL) and orexin (OX), to stimulate ethanol consumption, the question addressed here is whether prenatal ethanol alters the development in utero of specific neurons that express these peptides. Ethanol 125-132 galanin and GMAP prepropeptide Homo sapiens 81-88 22742906-2 2012 With studies in adult animals showing the orexigenic peptides, enkephalin (ENK), galanin (GAL) and orexin (OX), to stimulate ethanol consumption, the question addressed here is whether prenatal ethanol alters the development in utero of specific neurons that express these peptides. Ethanol 125-132 galanin and GMAP prepropeptide Homo sapiens 90-93 21983419-7 2012 In addition, four animals received an intracerebroventricular injection of colchicine known to increase the intracellular level of galanin immunoreactivity. Colchicine 75-85 galanin and GMAP prepropeptide Homo sapiens 131-138 21983419-9 2012 In colchicine-treated ewes, numerous Gal-immunoreactive neurones were found in the preoptic area in the vicinity of GnRH-immunoreactive neurones, but the two peptides were never observed in the same neurone. Colchicine 3-13 galanin and GMAP prepropeptide Homo sapiens 37-40 21983419-10 2012 In all animals, Gal-ir fibres were observed to be in apposition to GnRH-containing perikarya in the preoptic area and these appositions were more numerous in oestradiol-treated ewes than in control animals. Estradiol 158-168 galanin and GMAP prepropeptide Homo sapiens 16-19 21983419-13 2012 As in rodents and primates, galanin could mediate the positive feedback of oestradiol on GnRH neurones during the preovulatory surge in ewes. Estradiol 75-85 galanin and GMAP prepropeptide Homo sapiens 28-35 21414374-2 2011 We investigated whether CGX has hepatoprotective effects against lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced acute liver injury and its underlying mechanism(s). N4-cyclopropyl-5-ethyl-6-piperidin-1-yl-pyrimidine-2,4-diamine 24-27 galanin and GMAP prepropeptide Homo sapiens 107-111 21414374-8 2011 CGX attenuated LPS/D-GalN-induced lipid peroxidation with concomitant improvement in total antioxidant activities (superoxide dismutase, catalase, and glutathione peroxidase). N4-cyclopropyl-5-ethyl-6-piperidin-1-yl-pyrimidine-2,4-diamine 0-3 galanin and GMAP prepropeptide Homo sapiens 21-25 21414374-8 2011 CGX attenuated LPS/D-GalN-induced lipid peroxidation with concomitant improvement in total antioxidant activities (superoxide dismutase, catalase, and glutathione peroxidase). Deuterium 19-20 galanin and GMAP prepropeptide Homo sapiens 21-25 21414374-10 2011 Furthermore, LPS/D-GalN-induced alterations of neutrophil and lymphocyte populations were ameliorated and serum TNF-alpha was decreased significantly by CGX. N4-cyclopropyl-5-ethyl-6-piperidin-1-yl-pyrimidine-2,4-diamine 153-156 galanin and GMAP prepropeptide Homo sapiens 19-23 21414374-11 2011 From these data we conclude that CGX protects the liver from LPS/D-GalN-induced hepatitis through antioxidant mechanisms as well as immune modulation. N4-cyclopropyl-5-ethyl-6-piperidin-1-yl-pyrimidine-2,4-diamine 33-36 galanin and GMAP prepropeptide Homo sapiens 67-71 21414374-11 2011 From these data we conclude that CGX protects the liver from LPS/D-GalN-induced hepatitis through antioxidant mechanisms as well as immune modulation. Deuterium 65-66 galanin and GMAP prepropeptide Homo sapiens 67-71 21438637-4 2011 Specifically, the SS samples were functionalized with biologically significant carbohydrates [N-acetyl-D-glucosamine (GlcNAc) and D-galactose (Gal)] that contain trialkoxysilane derivatives as chemical handles for linking to the surface. trialkoxysilane derivatives 162-189 galanin and GMAP prepropeptide Homo sapiens 130-148 20696187-7 2011 Finally, these studies found that GAL could significantly inhibit the ability of AVP to stimulate flank marking in SP-housed hamsters and that there were no differences between hamsters housed in LP and SP in the ability of a GAL antagonist to inhibit AVP-induced flank marking. TFF2 protein, human 115-117 galanin and GMAP prepropeptide Homo sapiens 34-37 23788869-6 2012 The release of p-nitrophenol from p-nitrophenol derivatives of MAN and GAL was used. 4-nitrophenol 15-28 galanin and GMAP prepropeptide Homo sapiens 71-74 23788869-6 2012 The release of p-nitrophenol from p-nitrophenol derivatives of MAN and GAL was used. 4-nitrophenol 34-47 galanin and GMAP prepropeptide Homo sapiens 71-74 21641398-5 2011 Therefore, they must be artificially rendered susceptible to TSS by using sensitizing agents such as d-galactosamine (d-galN), which skews the disease exclusively to the liver and, hence, is not representative of the disease in humans. Galactosamine 101-116 galanin and GMAP prepropeptide Homo sapiens 120-124 21356237-1 2011 HPLC analysis proved that Coptis chinensis glycan contained Ara, Man, and Gal. Polysaccharides 43-49 galanin and GMAP prepropeptide Homo sapiens 74-77 21356237-3 2011 HPLC analysis proved that P. amurense glycan contained Ara, Xyl, Glu, and Gal. Polysaccharides 38-44 galanin and GMAP prepropeptide Homo sapiens 74-77 21251827-5 2011 Both the structural diversity of the amino acid (Ser, Thr, Phe and Tyr) introduced and the epimeric identity (Glc or Gal) on monosaccharide scaffold were determined to impact the corresponding inhibitory activity and selectivity. Monosaccharides 125-139 galanin and GMAP prepropeptide Homo sapiens 110-120 20645434-3 2010 Our recent studies with GAL analogs suggested that an introduction of lipoamino acids in the context of oligo-Lys residues (lipidization-cationization motif) significantly increases their penetration into the brain, yielding potent antiepileptic compounds. Lysine 110-113 galanin and GMAP prepropeptide Homo sapiens 24-27 20597468-3 2010 Hoechst-IR detects necrosis by binding extracellular DNA released from necrotic cells and was able to image necrosis generated from a myocardial infarction and lipopolysaccharide/d-galactosamine (LPS-GalN) induced sepsis. hoechst 0-7 galanin and GMAP prepropeptide Homo sapiens 200-204 20597468-3 2010 Hoechst-IR detects necrosis by binding extracellular DNA released from necrotic cells and was able to image necrosis generated from a myocardial infarction and lipopolysaccharide/d-galactosamine (LPS-GalN) induced sepsis. Galactosamine 179-194 galanin and GMAP prepropeptide Homo sapiens 200-204 20496884-4 2010 Here we show that a family 35 CBM member (CBM35), designated CtCBM35-Gal, binds to alpha-D-galactose (Gal) and, within the context of the plant cell wall, targets the alpha-1,6-Gal residues of galactomannan but not the beta-D-Gal residues in xyloglucan. ctcbm35-gal 61-72 galanin and GMAP prepropeptide Homo sapiens 83-106 20496884-4 2010 Here we show that a family 35 CBM member (CBM35), designated CtCBM35-Gal, binds to alpha-D-galactose (Gal) and, within the context of the plant cell wall, targets the alpha-1,6-Gal residues of galactomannan but not the beta-D-Gal residues in xyloglucan. galactomannan 193-206 galanin and GMAP prepropeptide Homo sapiens 83-106 20496884-4 2010 Here we show that a family 35 CBM member (CBM35), designated CtCBM35-Gal, binds to alpha-D-galactose (Gal) and, within the context of the plant cell wall, targets the alpha-1,6-Gal residues of galactomannan but not the beta-D-Gal residues in xyloglucan. beta-D-galactose 219-229 galanin and GMAP prepropeptide Homo sapiens 83-106 19501971-11 2010 The extensive recruitment of macrophages by anti-Gal/alpha-gal liposomes interaction was further demonstrated in vivo with polyvinyl alcohol (PVA) sponge discs containing alpha-gal liposomes, implanted subcutaneously. Polyvinyl Alcohol 123-140 galanin and GMAP prepropeptide Homo sapiens 49-52 20392659-4 2010 The capability of this new approach was demonstrated experimentally on uniformly (13)C-labeled Glutamine and a tripeptide sample, GAL. tripeptide K-26 111-121 galanin and GMAP prepropeptide Homo sapiens 130-133 19501971-11 2010 The extensive recruitment of macrophages by anti-Gal/alpha-gal liposomes interaction was further demonstrated in vivo with polyvinyl alcohol (PVA) sponge discs containing alpha-gal liposomes, implanted subcutaneously. Polyvinyl Alcohol 123-140 galanin and GMAP prepropeptide Homo sapiens 59-62 19501971-11 2010 The extensive recruitment of macrophages by anti-Gal/alpha-gal liposomes interaction was further demonstrated in vivo with polyvinyl alcohol (PVA) sponge discs containing alpha-gal liposomes, implanted subcutaneously. Polyvinyl Alcohol 142-145 galanin and GMAP prepropeptide Homo sapiens 49-52 19501971-11 2010 The extensive recruitment of macrophages by anti-Gal/alpha-gal liposomes interaction was further demonstrated in vivo with polyvinyl alcohol (PVA) sponge discs containing alpha-gal liposomes, implanted subcutaneously. Polyvinyl Alcohol 142-145 galanin and GMAP prepropeptide Homo sapiens 59-62 19560125-0 2009 Study on systematizing the synthesis of the a-series ganglioside glycans GT1a, GD1a, and GM1 using the newly developed N-Troc-protected GM3 and GalN intermediates. Gangliosides 53-64 galanin and GMAP prepropeptide Homo sapiens 144-148 21299064-0 2010 Galanin and consummatory behavior: special relationship with dietary fat, alcohol and circulating lipids. Alcohols 74-81 galanin and GMAP prepropeptide Homo sapiens 0-7 21299064-3 2010 In this relationship, GAL increases the consumption of fat or alcohol which, in turn, stimulates the expression of GAL, ultimately leading to overconsumption. Alcohols 62-69 galanin and GMAP prepropeptide Homo sapiens 22-25 21299064-3 2010 In this relationship, GAL increases the consumption of fat or alcohol which, in turn, stimulates the expression of GAL, ultimately leading to overconsumption. Alcohols 62-69 galanin and GMAP prepropeptide Homo sapiens 115-118 21299064-5 2010 These effects of GAL in promoting overconsumption may involve various neurotransmitters, with GAL facilitating intake by stimulating norepinephrine and dopamine and reducing satiety by decreasing serotonin and acetylcholine. Norepinephrine 133-147 galanin and GMAP prepropeptide Homo sapiens 94-97 21299064-5 2010 These effects of GAL in promoting overconsumption may involve various neurotransmitters, with GAL facilitating intake by stimulating norepinephrine and dopamine and reducing satiety by decreasing serotonin and acetylcholine. Dopamine 152-160 galanin and GMAP prepropeptide Homo sapiens 17-20 21299064-5 2010 These effects of GAL in promoting overconsumption may involve various neurotransmitters, with GAL facilitating intake by stimulating norepinephrine and dopamine and reducing satiety by decreasing serotonin and acetylcholine. Dopamine 152-160 galanin and GMAP prepropeptide Homo sapiens 94-97 21299064-5 2010 These effects of GAL in promoting overconsumption may involve various neurotransmitters, with GAL facilitating intake by stimulating norepinephrine and dopamine and reducing satiety by decreasing serotonin and acetylcholine. Serotonin 196-205 galanin and GMAP prepropeptide Homo sapiens 17-20 21299064-5 2010 These effects of GAL in promoting overconsumption may involve various neurotransmitters, with GAL facilitating intake by stimulating norepinephrine and dopamine and reducing satiety by decreasing serotonin and acetylcholine. Serotonin 196-205 galanin and GMAP prepropeptide Homo sapiens 94-97 21299064-7 2010 The relationship between GAL, fat, and alcohol may involve triglycerides, circulating lipids that are released by fat or alcohol and that correlate positively with hypothalamic GAL expression. Alcohols 39-46 galanin and GMAP prepropeptide Homo sapiens 25-28 21299064-7 2010 The relationship between GAL, fat, and alcohol may involve triglycerides, circulating lipids that are released by fat or alcohol and that correlate positively with hypothalamic GAL expression. Alcohols 39-46 galanin and GMAP prepropeptide Homo sapiens 177-180 21299064-7 2010 The relationship between GAL, fat, and alcohol may involve triglycerides, circulating lipids that are released by fat or alcohol and that correlate positively with hypothalamic GAL expression. Triglycerides 59-72 galanin and GMAP prepropeptide Homo sapiens 25-28 21299064-7 2010 The relationship between GAL, fat, and alcohol may involve triglycerides, circulating lipids that are released by fat or alcohol and that correlate positively with hypothalamic GAL expression. Triglycerides 59-72 galanin and GMAP prepropeptide Homo sapiens 177-180 21299064-7 2010 The relationship between GAL, fat, and alcohol may involve triglycerides, circulating lipids that are released by fat or alcohol and that correlate positively with hypothalamic GAL expression. Alcohols 121-128 galanin and GMAP prepropeptide Homo sapiens 25-28 21299064-8 2010 In females, levels of endogenous GAL also fluctuate across the reproductive cycle, driven by a rise in the ovarian steroids, estrogen, and progesterone. Steroids 115-123 galanin and GMAP prepropeptide Homo sapiens 33-36 21299064-8 2010 In females, levels of endogenous GAL also fluctuate across the reproductive cycle, driven by a rise in the ovarian steroids, estrogen, and progesterone. Progesterone 139-151 galanin and GMAP prepropeptide Homo sapiens 33-36 21299064-12 2010 By responding positively to fat and alcohol and guiding further neuronal development, GAL potentiates a long-term propensity to overconsume fat and alcohol. Alcohols 36-43 galanin and GMAP prepropeptide Homo sapiens 86-89 21299064-12 2010 By responding positively to fat and alcohol and guiding further neuronal development, GAL potentiates a long-term propensity to overconsume fat and alcohol. Alcohols 148-155 galanin and GMAP prepropeptide Homo sapiens 86-89 19523936-1 2009 D-Galactosamine (D-GalN) induces reactive oxygen species (ROS) generation and cell death in cultured hepatocytes. Galactosamine 0-15 galanin and GMAP prepropeptide Homo sapiens 19-23 19523936-1 2009 D-Galactosamine (D-GalN) induces reactive oxygen species (ROS) generation and cell death in cultured hepatocytes. Reactive Oxygen Species 33-56 galanin and GMAP prepropeptide Homo sapiens 19-23 19523936-1 2009 D-Galactosamine (D-GalN) induces reactive oxygen species (ROS) generation and cell death in cultured hepatocytes. Reactive Oxygen Species 58-61 galanin and GMAP prepropeptide Homo sapiens 19-23 19523936-6 2009 d-GalN induced a transient increase of mitochondrial hyperpolarization and oxidative stress, followed by an increase of oxidized/reduced GSH and Q(10) ratios, mitochondrial dysfunction and cell death in hepatocytes. Glutathione 137-140 galanin and GMAP prepropeptide Homo sapiens 2-6 19560125-0 2009 Study on systematizing the synthesis of the a-series ganglioside glycans GT1a, GD1a, and GM1 using the newly developed N-Troc-protected GM3 and GalN intermediates. Polysaccharides 65-72 galanin and GMAP prepropeptide Homo sapiens 144-148 19560125-0 2009 Study on systematizing the synthesis of the a-series ganglioside glycans GT1a, GD1a, and GM1 using the newly developed N-Troc-protected GM3 and GalN intermediates. G(M1) Ganglioside 89-92 galanin and GMAP prepropeptide Homo sapiens 144-148 19232311-2 2009 After degradation of the polysaccharides by acidic hydrolysis, the hexosamines produced (i.e., GlcN from Hep and GalN from OSCS) were derivatized with anthranilic acid (AA) and separated by means of CE in approximately 10 min with high sensitivity detection at 214 nm (limit of detection [LOD] of approximately 200 pg). Hexosamines 67-78 galanin and GMAP prepropeptide Homo sapiens 113-117 19232311-2 2009 After degradation of the polysaccharides by acidic hydrolysis, the hexosamines produced (i.e., GlcN from Hep and GalN from OSCS) were derivatized with anthranilic acid (AA) and separated by means of CE in approximately 10 min with high sensitivity detection at 214 nm (limit of detection [LOD] of approximately 200 pg). anthranilic acid 151-167 galanin and GMAP prepropeptide Homo sapiens 113-117 19087874-2 2009 In this issue, we explored the protective effects of asiatic acid and the relative mechanism in the D-galactosamine/lipopolysaccharide (D-GalN/LPS)-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system. asiatic acid 53-65 galanin and GMAP prepropeptide Homo sapiens 138-142 19136585-2 2009 Most known beta 3-N-acetylglucosaminyltransferases show a higher activity toward extending type 2 chain (Gal beta 1-4GlcNAc beta 1-), and an over-expression of beta 3GalT5 could suppress the formation of the type 2 chain poly-N-acetyllactosaminoglycans. beta 1-4glcnac 109-123 galanin and GMAP prepropeptide Homo sapiens 105-108 19136585-2 2009 Most known beta 3-N-acetylglucosaminyltransferases show a higher activity toward extending type 2 chain (Gal beta 1-4GlcNAc beta 1-), and an over-expression of beta 3GalT5 could suppress the formation of the type 2 chain poly-N-acetyllactosaminoglycans. poly-n-acetyllactosaminoglycans 221-252 galanin and GMAP prepropeptide Homo sapiens 105-108 19087874-2 2009 In this issue, we explored the protective effects of asiatic acid and the relative mechanism in the D-galactosamine/lipopolysaccharide (D-GalN/LPS)-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system. Galactosamine 100-115 galanin and GMAP prepropeptide Homo sapiens 138-142 19087874-5 2009 The results showed that D-GalN/LPS induced the increase of reactive oxygen species followed by extracellular signal-regulated kinase 1/2 (ERK 1/2) and nuclear factor-kappaB (NF-kappaB) activation. Reactive Oxygen Species 59-82 galanin and GMAP prepropeptide Homo sapiens 26-30 19087874-8 2009 Asiatic acid can protect the hepatocytes against D-GalN/LPS-induced hepatotoxicity. asiatic acid 0-12 galanin and GMAP prepropeptide Homo sapiens 51-55 19087874-10 2009 Taken together, asiatic acid can protect against D-GalN/LPS-induced hepatotoxicity partly via redox-regulated LTC(4)S expression pathway. asiatic acid 16-28 galanin and GMAP prepropeptide Homo sapiens 51-55 18274892-1 2008 GM1 epitope tetrasaccharide was synthesized by a condensation of sialyl-alpha(2-3)-gal acceptor and gal-beta(1-3)-GalN donor in a highly efficient manner. G(M1) Ganglioside 0-3 galanin and GMAP prepropeptide Homo sapiens 114-118 18988886-0 2009 Galanin preproprotein is associated with elevated plasma triglycerides. Triglycerides 57-70 galanin and GMAP prepropeptide Homo sapiens 0-21 18308781-0 2008 Galantamine treatment in Alzheimer"s disease with cerebrovascular disease: responder analyses from a randomized, controlled trial (GAL-INT-6). Galantamine 0-11 galanin and GMAP prepropeptide Homo sapiens 131-134 18274892-1 2008 GM1 epitope tetrasaccharide was synthesized by a condensation of sialyl-alpha(2-3)-gal acceptor and gal-beta(1-3)-GalN donor in a highly efficient manner. tetrasaccharide 12-27 galanin and GMAP prepropeptide Homo sapiens 114-118 18047841-0 2008 The Galalpha1,3Galbeta1,4GlcNAc-R (alpha-Gal) epitope: a carbohydrate of unique evolution and clinical relevance. Carbohydrates 57-69 galanin and GMAP prepropeptide Homo sapiens 4-7 18374124-2 2008 However, Galalpha1,3Gal (Gal) determinant elimination may expose cryptic carbohydrate antigens and/or generate new antigens that might interfere with the human immune response. Carbohydrates 73-85 galanin and GMAP prepropeptide Homo sapiens 9-23 18374124-2 2008 However, Galalpha1,3Gal (Gal) determinant elimination may expose cryptic carbohydrate antigens and/or generate new antigens that might interfere with the human immune response. Carbohydrates 73-85 galanin and GMAP prepropeptide Homo sapiens 9-12 18546155-1 2008 The major barrier in transplantation of pig organs into humans is the presence of surface carbohydrate antigens (e.g., the Gal alpha 1-3 Gal beta 1-4GlcNAc-R (alpha-Gal) epitope) expressed on pig endothelial cells. Carbohydrates 90-102 galanin and GMAP prepropeptide Homo sapiens 123-126 18546155-1 2008 The major barrier in transplantation of pig organs into humans is the presence of surface carbohydrate antigens (e.g., the Gal alpha 1-3 Gal beta 1-4GlcNAc-R (alpha-Gal) epitope) expressed on pig endothelial cells. Carbohydrates 90-102 galanin and GMAP prepropeptide Homo sapiens 137-140 18546155-1 2008 The major barrier in transplantation of pig organs into humans is the presence of surface carbohydrate antigens (e.g., the Gal alpha 1-3 Gal beta 1-4GlcNAc-R (alpha-Gal) epitope) expressed on pig endothelial cells. Carbohydrates 90-102 galanin and GMAP prepropeptide Homo sapiens 137-140 18546155-4 2008 As well as the known alpha-Gal antigens, some of these glycans contained novel non-Gal carbohydrate antigens such as (Neu5Gc-Gal-GlcNAc) and Gal alpha 1-3 Lewis(x) (Gal-Gal-(Fuc)GlcNAc) which have not been reported before in N-glycans from pig organs. Polysaccharides 55-62 galanin and GMAP prepropeptide Homo sapiens 83-86 18546155-4 2008 As well as the known alpha-Gal antigens, some of these glycans contained novel non-Gal carbohydrate antigens such as (Neu5Gc-Gal-GlcNAc) and Gal alpha 1-3 Lewis(x) (Gal-Gal-(Fuc)GlcNAc) which have not been reported before in N-glycans from pig organs. Polysaccharides 55-62 galanin and GMAP prepropeptide Homo sapiens 83-86 18546155-4 2008 As well as the known alpha-Gal antigens, some of these glycans contained novel non-Gal carbohydrate antigens such as (Neu5Gc-Gal-GlcNAc) and Gal alpha 1-3 Lewis(x) (Gal-Gal-(Fuc)GlcNAc) which have not been reported before in N-glycans from pig organs. Carbohydrates 87-99 galanin and GMAP prepropeptide Homo sapiens 83-86 18546155-4 2008 As well as the known alpha-Gal antigens, some of these glycans contained novel non-Gal carbohydrate antigens such as (Neu5Gc-Gal-GlcNAc) and Gal alpha 1-3 Lewis(x) (Gal-Gal-(Fuc)GlcNAc) which have not been reported before in N-glycans from pig organs. Carbohydrates 87-99 galanin and GMAP prepropeptide Homo sapiens 83-86 17869215-7 2007 Cell viability of SB-mediated telomerase overexpressing cells significantly increased by 48% (t-BH), 43% (CCl(4)), and 25% (d-GalN) in comparison to mock treated cells. Antimony 18-20 galanin and GMAP prepropeptide Homo sapiens 126-130 17869215-9 2007 In summary, SB transposon mediated telomerase gene transfer may have a protective effect against t-BH, CCl(4), or d-GalN induced acute cellular injury, and this results suggested SB-mediated telomerase therapy for tissue engineering. Antimony 12-14 galanin and GMAP prepropeptide Homo sapiens 116-120 17267065-4 2007 Here, we synthesized a novel pH-sensitive histidine-modified galactosylated cholesterol derivative (Gal-His-C4-Chol), for a more efficient gene delivery to hepatocytes. Histidine 42-51 galanin and GMAP prepropeptide Homo sapiens 100-103 17936189-2 2007 d-Galactosamine (D-GalN)-induced cell death is mediated by nitric oxide in hepatocytes, and it is associated with hepatic steatosis. Galactosamine 0-15 galanin and GMAP prepropeptide Homo sapiens 19-23 17936189-2 2007 d-Galactosamine (D-GalN)-induced cell death is mediated by nitric oxide in hepatocytes, and it is associated with hepatic steatosis. Nitric Oxide 59-71 galanin and GMAP prepropeptide Homo sapiens 19-23 17936189-3 2007 The beneficial properties of alpha-tocopherol and their relation to oxidative stress and gene regulation were assessed in D-GalN-induced cell death. alpha-Tocopherol 29-45 galanin and GMAP prepropeptide Homo sapiens 124-128 17936189-5 2007 alpha-Tocopherol (50 microM) was administered at the advanced stages (10 h) of D-GalN-induced cell death in cultured hepatocytes. alpha-Tocopherol 0-16 galanin and GMAP prepropeptide Homo sapiens 81-85 17936189-7 2007 D-GalN increased cell death and alpha-tocopherol metabolism. alpha-Tocopherol 32-48 galanin and GMAP prepropeptide Homo sapiens 2-6 17936189-8 2007 alpha-Tocopherol exerted a moderate beneficial effect against apoptosis and necrosis induced by D-GalN. alpha-Tocopherol 0-16 galanin and GMAP prepropeptide Homo sapiens 98-102 17601514-7 2007 Conformational analysis, using a combination of molecular mechanics, dynamics, and NMR spectroscopy, suggests that the difluoro-C-glycoside populates the non-exo-Gal/exo-Man conformer to a major extent (ca 50%), with a minor contribution ( approximately 15%) from the exo-Gal/exo-Man conformer that corresponds to the ground sate of the parent O-glycoside. difluoro-c-glycoside 119-139 galanin and GMAP prepropeptide Homo sapiens 162-165 17601514-7 2007 Conformational analysis, using a combination of molecular mechanics, dynamics, and NMR spectroscopy, suggests that the difluoro-C-glycoside populates the non-exo-Gal/exo-Man conformer to a major extent (ca 50%), with a minor contribution ( approximately 15%) from the exo-Gal/exo-Man conformer that corresponds to the ground sate of the parent O-glycoside. difluoro-c-glycoside 119-139 galanin and GMAP prepropeptide Homo sapiens 272-275 17601514-7 2007 Conformational analysis, using a combination of molecular mechanics, dynamics, and NMR spectroscopy, suggests that the difluoro-C-glycoside populates the non-exo-Gal/exo-Man conformer to a major extent (ca 50%), with a minor contribution ( approximately 15%) from the exo-Gal/exo-Man conformer that corresponds to the ground sate of the parent O-glycoside. o-glycoside 344-355 galanin and GMAP prepropeptide Homo sapiens 162-165 17267065-4 2007 Here, we synthesized a novel pH-sensitive histidine-modified galactosylated cholesterol derivative (Gal-His-C4-Chol), for a more efficient gene delivery to hepatocytes. Cholesterol 76-87 galanin and GMAP prepropeptide Homo sapiens 100-103 17267065-4 2007 Here, we synthesized a novel pH-sensitive histidine-modified galactosylated cholesterol derivative (Gal-His-C4-Chol), for a more efficient gene delivery to hepatocytes. imciromab pentetate 108-110 galanin and GMAP prepropeptide Homo sapiens 100-103 17267065-4 2007 Here, we synthesized a novel pH-sensitive histidine-modified galactosylated cholesterol derivative (Gal-His-C4-Chol), for a more efficient gene delivery to hepatocytes. chol 111-115 galanin and GMAP prepropeptide Homo sapiens 100-103 16314872-2 2006 Animal studies have implicated GAL in alcohol abuse and anxiety: chronic ethanol intake increases hypothalamic GAL mRNA; high levels of stress increase GAL release in the central amygdala. Ethanol 73-80 galanin and GMAP prepropeptide Homo sapiens 31-34 16647638-2 2006 The present study evaluated the role of nitric oxide (NO) during PGE(1) treatment in fully established d-GalN-induced cytotoxicity in cultured human hepatocytes. Nitric Oxide 40-52 galanin and GMAP prepropeptide Homo sapiens 105-109 16647638-4 2006 PGE(1) (1 microM) was administered at 2 h before d-GalN (40 mM), or 2 or 10 h after d-GalN in cultured hepatocytes. Prostaglandins E 0-4 galanin and GMAP prepropeptide Homo sapiens 51-55 16647638-4 2006 PGE(1) (1 microM) was administered at 2 h before d-GalN (40 mM), or 2 or 10 h after d-GalN in cultured hepatocytes. Prostaglandins E 0-4 galanin and GMAP prepropeptide Homo sapiens 86-90 16647638-8 2006 The administration of PGE(1) 10 h after d-GalN enhanced NF-kappaB activation, NOS-2 expression and nitrosative stress. Prostaglandins E 22-25 galanin and GMAP prepropeptide Homo sapiens 42-46 16647638-9 2006 Although PGE(1) administered at 2 h before or 2h after d-GalN reduced apoptosis and necrosis, its administration 10 h after d-GalN had no beneficial effect on cell death. Prostaglandins E 9-12 galanin and GMAP prepropeptide Homo sapiens 57-61 16647638-10 2006 In conclusion, the administration of PGE(1) during advanced d-GalN cytotoxicity induced nitrosative stress and lost its cytoprotective properties in cultured human hepatocytes. Prostaglandins E 37-40 galanin and GMAP prepropeptide Homo sapiens 62-66 17381688-5 2007 Two of three animals were given GAS914, a poly-L-lysine derivative shown to bind to anti-Gal xenoantibodies and neutralize them. Lysine 42-55 galanin and GMAP prepropeptide Homo sapiens 89-92 17381688-16 2007 We produced soluble scFv from this new gene to determine whether this antibody could bind to the Gal carbohydrate, and demonstrated that this protein was capable of blocking the binding of human serum xenoantibody to Gal oligosaccharide, as had previously been shown with human V(H)3-11 scFv. Oligosaccharides 221-236 galanin and GMAP prepropeptide Homo sapiens 97-100 17381688-16 2007 We produced soluble scFv from this new gene to determine whether this antibody could bind to the Gal carbohydrate, and demonstrated that this protein was capable of blocking the binding of human serum xenoantibody to Gal oligosaccharide, as had previously been shown with human V(H)3-11 scFv. Oligosaccharides 221-236 galanin and GMAP prepropeptide Homo sapiens 217-220 17164178-1 2007 Nitric oxide (NO) participates in the cell death induced by d-Galactosamine (d-GalN) in hepatocytes, and NO-derived reactive oxygen intermediates are critical contributors to protein modification and hepatocellular injury. Nitric Oxide 0-12 galanin and GMAP prepropeptide Homo sapiens 79-83 17164178-1 2007 Nitric oxide (NO) participates in the cell death induced by d-Galactosamine (d-GalN) in hepatocytes, and NO-derived reactive oxygen intermediates are critical contributors to protein modification and hepatocellular injury. Galactosamine 60-75 galanin and GMAP prepropeptide Homo sapiens 79-83 17164178-3 2007 In the present study, d-GalN-induced cell death was related to augmented levels of NO production and S-nitrosothiol (SNO) content. S-Nitrosothiols 101-115 galanin and GMAP prepropeptide Homo sapiens 24-28 17164178-3 2007 In the present study, d-GalN-induced cell death was related to augmented levels of NO production and S-nitrosothiol (SNO) content. S-Nitrosothiols 117-120 galanin and GMAP prepropeptide Homo sapiens 24-28 17164178-4 2007 The biotin switch assay confirmed that d-GalN increased the levels of S-nitrosated proteins in human hepatocytes. Biotin 4-10 galanin and GMAP prepropeptide Homo sapiens 41-45 17164178-7 2007 Among them, seven were also identified in d-GalN-treated hepatocytes. Deuterium 29-30 galanin and GMAP prepropeptide Homo sapiens 44-48 17164178-8 2007 The results here reported underline the importance of the alteration of SNO homeostasis during d-GalN-induced cell death in human hepatocytes. S-Nitrosothiols 72-75 galanin and GMAP prepropeptide Homo sapiens 97-101 17117548-0 2006 [Galanin increases the survival rate of hippocampal cells injured by H2O2 in vitro]. Hydrogen Peroxide 69-73 galanin and GMAP prepropeptide Homo sapiens 1-8 17117548-3 2006 GAL and GAL"s nonselective agonist GAL1-11, GalR2"s selective agonist GAL2-11 can increase the survival rate of hippocampal cells suffered form H2O2. Hydrogen Peroxide 144-148 galanin and GMAP prepropeptide Homo sapiens 0-3 17117548-3 2006 GAL and GAL"s nonselective agonist GAL1-11, GalR2"s selective agonist GAL2-11 can increase the survival rate of hippocampal cells suffered form H2O2. Hydrogen Peroxide 144-148 galanin and GMAP prepropeptide Homo sapiens 8-11 16314872-2 2006 Animal studies have implicated GAL in alcohol abuse and anxiety: chronic ethanol intake increases hypothalamic GAL mRNA; high levels of stress increase GAL release in the central amygdala. Ethanol 73-80 galanin and GMAP prepropeptide Homo sapiens 111-114 16314872-2 2006 Animal studies have implicated GAL in alcohol abuse and anxiety: chronic ethanol intake increases hypothalamic GAL mRNA; high levels of stress increase GAL release in the central amygdala. Ethanol 73-80 galanin and GMAP prepropeptide Homo sapiens 111-114 16343079-1 2005 BACKGROUND/AIMS: Hepatic injury by d-galactosamine (d-GalN) is a suitable experimental model of hepatocellular injury. Galactosamine 35-50 galanin and GMAP prepropeptide Homo sapiens 54-58 16343079-9 2005 d-GalN increased tyrosine nitration of four cytosolic (Hsc70, Hsp70, annexin A4 and carbonyl reductase) and three mitochondrial (glycine amidinotransferase, ATP synthase beta chain, and thiosulfate sulfurtransferase) proteins in human hepatocytes. Tyrosine 17-25 galanin and GMAP prepropeptide Homo sapiens 2-6 16343079-10 2005 CONCLUSIONS: The results provide evidences that oxidative stress and nitric oxide-derived reactive oxygen intermediates induce specific alterations in protein expression that may be critical for the induction of apoptosis and necrosis by d-GalN in cultured human hepatocytes. Nitric Oxide 69-81 galanin and GMAP prepropeptide Homo sapiens 240-244 16343079-10 2005 CONCLUSIONS: The results provide evidences that oxidative stress and nitric oxide-derived reactive oxygen intermediates induce specific alterations in protein expression that may be critical for the induction of apoptosis and necrosis by d-GalN in cultured human hepatocytes. Oxygen 99-105 galanin and GMAP prepropeptide Homo sapiens 240-244 15880045-1 2005 BACKGROUND: The expression of galactose-alpha(1,3)galactose (Gal) on porcine cells represents a major barrier to xenotransplantation. galactosyl-(1-3)galactose 30-59 galanin and GMAP prepropeptide Homo sapiens 61-64 15944024-3 2005 It is possible that such a function may be revealed by examining the interaction of GAL with norepinephrine (NE), with which it is prominently co-localized. Norepinephrine 93-107 galanin and GMAP prepropeptide Homo sapiens 84-87 15944024-4 2005 We showed previously that enhancing stress-activation of the NE system by yohimbine (YOH) pretreatment induced the release of GAL in central amygdala (CeA) to exert an anxiolytic effect on the elevated plus-maze. Yohimbine 74-83 galanin and GMAP prepropeptide Homo sapiens 126-129 15944024-4 2005 We showed previously that enhancing stress-activation of the NE system by yohimbine (YOH) pretreatment induced the release of GAL in central amygdala (CeA) to exert an anxiolytic effect on the elevated plus-maze. Yohimbine 85-88 galanin and GMAP prepropeptide Homo sapiens 126-129 12620377-3 2003 The aim of the present study was to investigate the role of NO during PGE(1) protection against D-galactosamine (D-GalN) citotoxicity in cultured hepatocytes. Prostaglandins E 70-73 galanin and GMAP prepropeptide Homo sapiens 115-119 15465628-3 2004 Previous studies indicate pre-treatment with guanine nucleotides displaces endogenous GAL from GAL receptors (GALR), providing an indirect measurement of GALR occupancy. Guanine Nucleotides 45-64 galanin and GMAP prepropeptide Homo sapiens 86-89 15465628-4 2004 In addition, pre-treatment with guanine nucleotides may provide a more accurate measurement of GALR density since it would avoid the masking of GALRs by residual binding of endogenous GAL. Guanine Nucleotides 32-51 galanin and GMAP prepropeptide Homo sapiens 95-98 15465628-5 2004 Thus, in the present study, we examined the influence of pre-treatment with guanine nucleotides on 125I-GAL binding in multiple regions of normal and AD brain. Guanine Nucleotides 76-95 galanin and GMAP prepropeptide Homo sapiens 104-107 15465628-6 2004 Our results indicate that GTP pre-treatment enhances GAL binding in specific regions in normal and AD brain. Guanosine Triphosphate 26-29 galanin and GMAP prepropeptide Homo sapiens 53-56 15374745-8 2004 These results suggest that the early increase of GAL in the CA1 pyramidal cells may be associated with the reduction of the excitotoxic damage, that long-lasting enhanced expression of endogenous GAL at 12 h-2 days after ischemia may be associated with efflux of potassium ion into the extracellular space, and that GAL expression in microglia 4 days after ischemia may be associated with reduction of ischemic damage. Potassium 263-272 galanin and GMAP prepropeptide Homo sapiens 196-199 15374745-8 2004 These results suggest that the early increase of GAL in the CA1 pyramidal cells may be associated with the reduction of the excitotoxic damage, that long-lasting enhanced expression of endogenous GAL at 12 h-2 days after ischemia may be associated with efflux of potassium ion into the extracellular space, and that GAL expression in microglia 4 days after ischemia may be associated with reduction of ischemic damage. Potassium 263-272 galanin and GMAP prepropeptide Homo sapiens 196-199 15275747-1 2004 We investigated the peripheral function of galanin (GAL) in capsaicin (CAP)-induced inflammatory pain. Capsaicin 60-69 galanin and GMAP prepropeptide Homo sapiens 43-50 15275747-1 2004 We investigated the peripheral function of galanin (GAL) in capsaicin (CAP)-induced inflammatory pain. Capsaicin 60-69 galanin and GMAP prepropeptide Homo sapiens 52-55 15275747-1 2004 We investigated the peripheral function of galanin (GAL) in capsaicin (CAP)-induced inflammatory pain. Capsaicin 71-74 galanin and GMAP prepropeptide Homo sapiens 43-50 14610237-4 2004 Intrathecal injection of rat galanin (Gal(1-29)) or human galanin (Gal(1-30)) produced a dose-dependent inhibition of formalin-evoked flinching in phase 2, but not in phase 1. Formaldehyde 118-126 galanin and GMAP prepropeptide Homo sapiens 58-65 14610237-4 2004 Intrathecal injection of rat galanin (Gal(1-29)) or human galanin (Gal(1-30)) produced a dose-dependent inhibition of formalin-evoked flinching in phase 2, but not in phase 1. Formaldehyde 118-126 galanin and GMAP prepropeptide Homo sapiens 67-70 14960194-4 2004 RESULTS: HO-1 induction with cobalt protoporphorin (Co-PP) dose-dependently protected against apoptotic cell death as well as neutrophil-mediated oncosis in the galactosamine/endotoxin (Gal/ET) shock model. cobalt protoporphorin 29-50 galanin and GMAP prepropeptide Homo sapiens 186-189 14960194-4 2004 RESULTS: HO-1 induction with cobalt protoporphorin (Co-PP) dose-dependently protected against apoptotic cell death as well as neutrophil-mediated oncosis in the galactosamine/endotoxin (Gal/ET) shock model. co-pp 52-57 galanin and GMAP prepropeptide Homo sapiens 186-189 14960194-7 2004 Furthermore, a similar protective effect with the high dose of Co-PP was observed when animals were treated with Gal/TNF-alpha. co-pp 63-68 galanin and GMAP prepropeptide Homo sapiens 113-116 14631106-0 2003 Carbohydrate structural units in glycoproteins and polysaccharides as important ligands for Gal and GalNAc reactive lectins. Carbohydrates 0-12 galanin and GMAP prepropeptide Homo sapiens 92-95 14631106-0 2003 Carbohydrate structural units in glycoproteins and polysaccharides as important ligands for Gal and GalNAc reactive lectins. Polysaccharides 51-66 galanin and GMAP prepropeptide Homo sapiens 92-95 14631106-12 2003 To facilitate the selection of lectins that could serve as structural probes, the carbohydrate binding properties of Gal/GalNAc reactive lectins have been classified according to their highest affinity for structural units and their binding profiles are expressed in decreasing order of reactivity. Carbohydrates 82-94 galanin and GMAP prepropeptide Homo sapiens 117-120 14631106-12 2003 To facilitate the selection of lectins that could serve as structural probes, the carbohydrate binding properties of Gal/GalNAc reactive lectins have been classified according to their highest affinity for structural units and their binding profiles are expressed in decreasing order of reactivity. N-acetylgalactosaminuronic acid 121-127 galanin and GMAP prepropeptide Homo sapiens 117-120 14631106-13 2003 Hence, the binding relationship between glycoproteins and Gal/GalNAc specific lectins can be explored. N-acetylgalactosaminuronic acid 62-68 galanin and GMAP prepropeptide Homo sapiens 58-61 12647269-2 2003 Galanin (GAL) is a neuropeptide, widely distributed in the central and peripheral nervous systems, that interacts with both sympathetic and vagal systems as well as with neurotransmitters, such as serotonin. Serotonin 197-206 galanin and GMAP prepropeptide Homo sapiens 0-7 12647269-2 2003 Galanin (GAL) is a neuropeptide, widely distributed in the central and peripheral nervous systems, that interacts with both sympathetic and vagal systems as well as with neurotransmitters, such as serotonin. Serotonin 197-206 galanin and GMAP prepropeptide Homo sapiens 9-12 12620377-3 2003 The aim of the present study was to investigate the role of NO during PGE(1) protection against D-galactosamine (D-GalN) citotoxicity in cultured hepatocytes. Galactosamine 96-111 galanin and GMAP prepropeptide Homo sapiens 115-119 12620377-4 2003 PGE(1) was preadministered to D-GalN-treated hepatocytes. Alprostadil 0-6 galanin and GMAP prepropeptide Homo sapiens 32-36 12620377-8 2003 PGE(1) protection against D-GalN injury was associated with its capacity to reduce iNOS expression and NO production induced by D-GalN. Prostaglandins E 0-3 galanin and GMAP prepropeptide Homo sapiens 28-32 12620377-12 2003 The present study suggests that low NO production induced by PGE(1) preadministration reduces D-GalN-induced cell death through its capacity to reduce iNOS expression and NO production caused by the hepatotoxin. Prostaglandins E 61-64 galanin and GMAP prepropeptide Homo sapiens 96-100 12471460-0 2003 125I-labeled galanin binding sites in congenital innervation defects of the distal colon. Iodine-125 0-4 galanin and GMAP prepropeptide Homo sapiens 13-20 12471460-6 2003 An increased population of GAL receptor positive, parasympathetic nerve fibers was seen in the aganglionic segment of HD as compared to controls and IND B. ind b 149-154 galanin and GMAP prepropeptide Homo sapiens 27-30 12371933-3 2002 Here, we present evidence suggesting that the majority of human anti-non-Gal antibodies are specific for carbohydrate structures carrying terminally linked N-glycolylneuraminic acid (NeuGc), a xenoantigen existing in almost all animals except humans. Carbohydrates 105-117 galanin and GMAP prepropeptide Homo sapiens 73-76 12371933-3 2002 Here, we present evidence suggesting that the majority of human anti-non-Gal antibodies are specific for carbohydrate structures carrying terminally linked N-glycolylneuraminic acid (NeuGc), a xenoantigen existing in almost all animals except humans. N-glycolylneuraminic acid 156-181 galanin and GMAP prepropeptide Homo sapiens 73-76 12371933-3 2002 Here, we present evidence suggesting that the majority of human anti-non-Gal antibodies are specific for carbohydrate structures carrying terminally linked N-glycolylneuraminic acid (NeuGc), a xenoantigen existing in almost all animals except humans. N-glycolylneuraminic acid 183-188 galanin and GMAP prepropeptide Homo sapiens 73-76 12099826-4 2002 About 56%, 54%, and 94% of the available anhydride groups reacted to give galactosyl-amide (SMA-Gal), glucosyl-amide (SMA-Gluc), and lactosyl-amide (SMA-Lac) branched polymers, respectively. galactosyl-amide 74-90 galanin and GMAP prepropeptide Homo sapiens 96-99 12374194-0 2002 Carbohydrate structural units in glycosphingolipids as receptors for Gal and GalNAc reactive lectins. Carbohydrates 0-12 galanin and GMAP prepropeptide Homo sapiens 69-72 12374194-0 2002 Carbohydrate structural units in glycosphingolipids as receptors for Gal and GalNAc reactive lectins. Glycosphingolipids 33-51 galanin and GMAP prepropeptide Homo sapiens 69-72 12374194-1 2002 Glycosphingolipids (GSLs) contain many carbohydrate epitopes or crypto-glycotopes for Gal and GalNAc reactive lectins. Carbohydrates 39-51 galanin and GMAP prepropeptide Homo sapiens 86-89 12374194-7 2002 To facilitate the selection of lectins that could serve as structural probes, the carbohydrate binding specificities of Gal/GalNAc reactive lectins have been classified according to their highest affinity for the structural units and their binding properties expressed by decreasing order of reactivity. Carbohydrates 82-94 galanin and GMAP prepropeptide Homo sapiens 120-123 12374194-7 2002 To facilitate the selection of lectins that could serve as structural probes, the carbohydrate binding specificities of Gal/GalNAc reactive lectins have been classified according to their highest affinity for the structural units and their binding properties expressed by decreasing order of reactivity. N-acetylgalactosaminuronic acid 124-130 galanin and GMAP prepropeptide Homo sapiens 120-123 12374194-8 2002 Hence, the binding relation between GSLs and Gal/GalNAc specific lectins can be established. Glycosphingolipids 36-40 galanin and GMAP prepropeptide Homo sapiens 45-48 12374194-8 2002 Hence, the binding relation between GSLs and Gal/GalNAc specific lectins can be established. N-acetylgalactosaminuronic acid 49-55 galanin and GMAP prepropeptide Homo sapiens 45-48 12099826-4 2002 About 56%, 54%, and 94% of the available anhydride groups reacted to give galactosyl-amide (SMA-Gal), glucosyl-amide (SMA-Gluc), and lactosyl-amide (SMA-Lac) branched polymers, respectively. poly(styrene-co-maleic anhydride) 92-95 galanin and GMAP prepropeptide Homo sapiens 96-99 12099826-4 2002 About 56%, 54%, and 94% of the available anhydride groups reacted to give galactosyl-amide (SMA-Gal), glucosyl-amide (SMA-Gluc), and lactosyl-amide (SMA-Lac) branched polymers, respectively. lactosyl-amide 76-90 galanin and GMAP prepropeptide Homo sapiens 96-99 11818519-9 2002 Transfection studies revealed that in the presence of 100 nmol/l estradiol-17 beta (E(2)), a minimal 0.3 kb promoter construct (pH-298/+25 beta Gal) mediated a high level of beta-Gal expression in immortalized human oviductal epithelial OE-E6/E7 cells, but not in MCF-7 and CHO-K1 cells. Estradiol 65-82 galanin and GMAP prepropeptide Homo sapiens 144-147 11983014-1 2002 The hyperacute rejection observed in models of pig-to-human xenotransplantation is mainly because of the presence of natural antibodies in human blood with specificity for the Galalpha(1-3)Gal (Gal) carbohydrate moiety present on the surface of porcine endothelial cells. Carbohydrates 199-211 galanin and GMAP prepropeptide Homo sapiens 176-192 11983014-1 2002 The hyperacute rejection observed in models of pig-to-human xenotransplantation is mainly because of the presence of natural antibodies in human blood with specificity for the Galalpha(1-3)Gal (Gal) carbohydrate moiety present on the surface of porcine endothelial cells. Carbohydrates 199-211 galanin and GMAP prepropeptide Homo sapiens 176-179 12071354-1 2002 D-galactosamine (D-GalN) toxicity is a useful experimental model of liver failure in human. Galactosamine 0-15 galanin and GMAP prepropeptide Homo sapiens 19-23 11487315-0 2001 Preparation, characterization, and luminescence properties of gallium-metal face-to-face diporphyrins (M = H(2), GaL, Ru(CO)(OH), Co). Gallium 62-69 galanin and GMAP prepropeptide Homo sapiens 113-116 12448081-8 2002 The co-localization of GAL and dopamine beta-hydroxylase (D beta H--a key enzyme of the noradrenaline synthesis pathway) in perivascular nerve fibers could lead to considerable vasospasms in the pancreas, resulting in deeper hypoxia of the organ. Norepinephrine 88-101 galanin and GMAP prepropeptide Homo sapiens 23-26 11487315-0 2001 Preparation, characterization, and luminescence properties of gallium-metal face-to-face diporphyrins (M = H(2), GaL, Ru(CO)(OH), Co). diporphyrins 89-101 galanin and GMAP prepropeptide Homo sapiens 113-116 11487315-1 2001 The preparation and characterization of a new series of mixed metal cofacial anthracene-bridged diporphyrins (DPA) containing a GaL fragment (L = OMe, OH) and another metallic center (M = GaL, Ru(CO)(OH), Co, and H(2) (i.e. free base)) are reported. diporphyrins 96-108 galanin and GMAP prepropeptide Homo sapiens 128-131 11487315-1 2001 The preparation and characterization of a new series of mixed metal cofacial anthracene-bridged diporphyrins (DPA) containing a GaL fragment (L = OMe, OH) and another metallic center (M = GaL, Ru(CO)(OH), Co, and H(2) (i.e. free base)) are reported. dpa 110-113 galanin and GMAP prepropeptide Homo sapiens 128-131 11487315-5 2001 On the basis of a comparison with photophysical data on GaL monoporphyrins, the weak fluorescence and absence of phosphorescence for most cases indicate efficient intramolecular quenching. monoporphyrins 60-74 galanin and GMAP prepropeptide Homo sapiens 56-59 11027855-7 2000 The copresence VIP/Gal/NOS as well as PACAP/VIP were revealed in some NADPH-d-neurons. NADP 70-75 galanin and GMAP prepropeptide Homo sapiens 19-22 11468550-1 2001 BACKGROUND: Natural antibodies that react with galactose-alpha(1,3)galactose [galalpha(1,3)gal] carbohydrate epitopes exist in humans and Old World primates because of the inactivation of the alpha1,3-galactosyltransferase (alpha1,3GT) gene in these species and the subsequent production of antibodies to environmental microbes that express the galalpha(1,3)gal antigen. Galactose 47-56 galanin and GMAP prepropeptide Homo sapiens 67-70 11468550-1 2001 BACKGROUND: Natural antibodies that react with galactose-alpha(1,3)galactose [galalpha(1,3)gal] carbohydrate epitopes exist in humans and Old World primates because of the inactivation of the alpha1,3-galactosyltransferase (alpha1,3GT) gene in these species and the subsequent production of antibodies to environmental microbes that express the galalpha(1,3)gal antigen. alpha(1,3)galactose 57-76 galanin and GMAP prepropeptide Homo sapiens 47-50 11468550-2 2001 The Gal knockout (Gal o/o) mouse, produced by homologous disruption of the alpha1,3GT gene, spontaneously makes anti-galalpha(1,3)gal antibodies and can be used to study the genetic control of humoral immune responses to this carbohydrate epitope. Carbohydrates 226-238 galanin and GMAP prepropeptide Homo sapiens 4-7 11161729-8 2001 ICN immunoreactive for nNOS or GAL spread over the entire choroid, although they were concentrated in an equatorial zone passing obliquely from naso-cranial to temporo-caudal. icn 0-3 galanin and GMAP prepropeptide Homo sapiens 31-34 11027855-9 2000 Moreover the presence of VIP, Gal and PACAP in some NADPH-d-containing neurons enhances the inhibitory actions of these neurotransmitters whereas PACAP and Gal role is actually unknown. [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoyl-4-deuterio-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate 52-59 galanin and GMAP prepropeptide Homo sapiens 30-33 10385697-6 1999 Transcriptional activation required the galanin 12-O-tetradecanoylphorbol-13-acetate (phorbol-12-myristate-13-acetate) response element (GTRE) octamer sequence (TGACGCGG) in the proximal enhancer of the GAL gene, previously shown to confer phorbol ester responsiveness in chromaffin cells. Phorbol Esters 240-253 galanin and GMAP prepropeptide Homo sapiens 40-47 10818256-1 2000 Hypertrophy of fibers containing galanin (GAL), the inhibitory neurotransmitter of acetylcholine, occur on remaining cholinergic nucleus basalis neurons in late stage Alzheimer"s disease (AD). Acetylcholine 83-96 galanin and GMAP prepropeptide Homo sapiens 33-40 10818256-1 2000 Hypertrophy of fibers containing galanin (GAL), the inhibitory neurotransmitter of acetylcholine, occur on remaining cholinergic nucleus basalis neurons in late stage Alzheimer"s disease (AD). Acetylcholine 83-96 galanin and GMAP prepropeptide Homo sapiens 42-45 10827009-10 2000 Both hGAL-(1-30) and -(3-30) potentiated the rise in GHRH-stimulated GH levels [area under the curve (AUC), saline, 2,810 +/- 500 vs. hGAL-(1-30), 4,660 +/- 737, P < 0.01; vs. hGAL-(3-30), 6, 870 +/- 1,550 ng. Sodium Chloride 108-114 galanin and GMAP prepropeptide Homo sapiens 5-9 10385697-1 1999 We investigated trans-acting factors mediating galanin (GAL) gene activation by protein kinase-dependent signal transduction pathways in chromaffin cells. chromaffin 137-147 galanin and GMAP prepropeptide Homo sapiens 47-54 10385697-1 1999 We investigated trans-acting factors mediating galanin (GAL) gene activation by protein kinase-dependent signal transduction pathways in chromaffin cells. chromaffin 137-147 galanin and GMAP prepropeptide Homo sapiens 56-59 10385697-2 1999 GAL mRNA up-regulation via the protein kinase A (PKA) pathway (25 microM forskolin) required new protein synthesis. Colforsin 73-82 galanin and GMAP prepropeptide Homo sapiens 0-3 10385697-6 1999 Transcriptional activation required the galanin 12-O-tetradecanoylphorbol-13-acetate (phorbol-12-myristate-13-acetate) response element (GTRE) octamer sequence (TGACGCGG) in the proximal enhancer of the GAL gene, previously shown to confer phorbol ester responsiveness in chromaffin cells. Tetradecanoylphorbol Acetate 48-84 galanin and GMAP prepropeptide Homo sapiens 40-47 10385697-6 1999 Transcriptional activation required the galanin 12-O-tetradecanoylphorbol-13-acetate (phorbol-12-myristate-13-acetate) response element (GTRE) octamer sequence (TGACGCGG) in the proximal enhancer of the GAL gene, previously shown to confer phorbol ester responsiveness in chromaffin cells. Tetradecanoylphorbol Acetate 48-84 galanin and GMAP prepropeptide Homo sapiens 203-206 10385697-6 1999 Transcriptional activation required the galanin 12-O-tetradecanoylphorbol-13-acetate (phorbol-12-myristate-13-acetate) response element (GTRE) octamer sequence (TGACGCGG) in the proximal enhancer of the GAL gene, previously shown to confer phorbol ester responsiveness in chromaffin cells. Tetradecanoylphorbol Acetate 86-117 galanin and GMAP prepropeptide Homo sapiens 40-47 10385697-6 1999 Transcriptional activation required the galanin 12-O-tetradecanoylphorbol-13-acetate (phorbol-12-myristate-13-acetate) response element (GTRE) octamer sequence (TGACGCGG) in the proximal enhancer of the GAL gene, previously shown to confer phorbol ester responsiveness in chromaffin cells. Tetradecanoylphorbol Acetate 86-117 galanin and GMAP prepropeptide Homo sapiens 203-206 10385697-6 1999 Transcriptional activation required the galanin 12-O-tetradecanoylphorbol-13-acetate (phorbol-12-myristate-13-acetate) response element (GTRE) octamer sequence (TGACGCGG) in the proximal enhancer of the GAL gene, previously shown to confer phorbol ester responsiveness in chromaffin cells. chromaffin 272-282 galanin and GMAP prepropeptide Homo sapiens 40-47 10385697-11 1999 Elevated potassium stimulation of GAL mRNA was completely blocked, but pituitary adenylyl cyclase-activating polypeptide and histamine stimulations were only partially blocked, by cycloheximide. Potassium 9-18 galanin and GMAP prepropeptide Homo sapiens 34-37 10218835-2 1999 Our results demonstrate that, though these two galactosyltransferases both utilize the same donor sugar-nucleotide (UDP-Gal), the difference in their mechanisms can be utilized to design donor sugar or nucleotide analogues with inhibitory activities selective for only one of the galactosyltransferases. sugar-nucleotide 98-114 galanin and GMAP prepropeptide Homo sapiens 120-123 10218835-2 1999 Our results demonstrate that, though these two galactosyltransferases both utilize the same donor sugar-nucleotide (UDP-Gal), the difference in their mechanisms can be utilized to design donor sugar or nucleotide analogues with inhibitory activities selective for only one of the galactosyltransferases. Sugars 98-103 galanin and GMAP prepropeptide Homo sapiens 120-123 9275119-1 1997 BACKGROUND: The cell surface carbohydrate moiety, Gal(alpha1,3)Galactose (alphaGal), has been implicated as the major determinant recognized by more than 80% of human anti-porcine natural antibodies (NAb). Carbohydrates 29-41 galanin and GMAP prepropeptide Homo sapiens 50-72 10403497-7 1999 In the oviduct of non-reproductive females, 17beta-estradiol administration induced a significant increase of neurons containing Gal/IR. Estradiol 44-60 galanin and GMAP prepropeptide Homo sapiens 129-132 9928172-4 1998 This function of aPVN GAL neurons is carried out in close relation to circulating insulin and glucose. Glucose 94-101 galanin and GMAP prepropeptide Homo sapiens 22-25 9928172-5 1998 Galanin-expressing perikarya in the medial preoptic area (MPOA) have a similar function, although GAL here operates in association with the female steroids estrogen and progesterone. Steroids 147-155 galanin and GMAP prepropeptide Homo sapiens 98-101 9928183-2 1998 It is hypothesized that increased activity of the locus coeruleus (LC) neurons, the principal norepinephrine (NE)-containing cells in the brain, causes release of galanin (GAL) in the ventral tegmentum (VTA) from LC axon terminals in which GAL is colocalized with NE. Norepinephrine 94-108 galanin and GMAP prepropeptide Homo sapiens 163-170 9928183-2 1998 It is hypothesized that increased activity of the locus coeruleus (LC) neurons, the principal norepinephrine (NE)-containing cells in the brain, causes release of galanin (GAL) in the ventral tegmentum (VTA) from LC axon terminals in which GAL is colocalized with NE. Norepinephrine 94-108 galanin and GMAP prepropeptide Homo sapiens 172-175 9726228-5 1998 Histological assessment of Gal-expressing cells revealed that 54.9 +/- 8.8% stained positive for either insulin or glucagon. Glucagon 115-123 galanin and GMAP prepropeptide Homo sapiens 27-30 9600091-1 1998 The expression of the neuropeptide galanin (GAL) is elevated in vivo upon nerve stimulation, injury, and in vitro by phorbol 12-myristate-13-acetate (PMA), suggesting that a signal pathway involving protein kinase C activation may be involved in GAL-gene activation. Tetradecanoylphorbol Acetate 117-148 galanin and GMAP prepropeptide Homo sapiens 35-42 9600091-1 1998 The expression of the neuropeptide galanin (GAL) is elevated in vivo upon nerve stimulation, injury, and in vitro by phorbol 12-myristate-13-acetate (PMA), suggesting that a signal pathway involving protein kinase C activation may be involved in GAL-gene activation. Tetradecanoylphorbol Acetate 117-148 galanin and GMAP prepropeptide Homo sapiens 44-47 9600091-1 1998 The expression of the neuropeptide galanin (GAL) is elevated in vivo upon nerve stimulation, injury, and in vitro by phorbol 12-myristate-13-acetate (PMA), suggesting that a signal pathway involving protein kinase C activation may be involved in GAL-gene activation. Tetradecanoylphorbol Acetate 150-153 galanin and GMAP prepropeptide Homo sapiens 35-42 9600091-1 1998 The expression of the neuropeptide galanin (GAL) is elevated in vivo upon nerve stimulation, injury, and in vitro by phorbol 12-myristate-13-acetate (PMA), suggesting that a signal pathway involving protein kinase C activation may be involved in GAL-gene activation. Tetradecanoylphorbol Acetate 150-153 galanin and GMAP prepropeptide Homo sapiens 44-47 9556077-6 1998 Kinetic experiments showed that saturation of GALR sites by [125I]GAL (human) (hGAL) occurred within 2 h and that this binding readily reversed in the presence of a GTP analog, but not in the presence of excess unlabeled hGAL. Guanosine Triphosphate 165-168 galanin and GMAP prepropeptide Homo sapiens 46-49 9556077-6 1998 Kinetic experiments showed that saturation of GALR sites by [125I]GAL (human) (hGAL) occurred within 2 h and that this binding readily reversed in the presence of a GTP analog, but not in the presence of excess unlabeled hGAL. Guanosine Triphosphate 165-168 galanin and GMAP prepropeptide Homo sapiens 79-83 10221824-2 1998 Hepatotoxicity induced by D-galactosamine (D-GalN) is a suitable animal model of human acute hepatic failure. Galactosamine 26-41 galanin and GMAP prepropeptide Homo sapiens 45-49 9459305-5 1997 This applied to both types of polysaccharide chains found in PGs, namely the galactosaminoglycuronans (GalN-GAGs) and the glucosaminoglycuronans (GlcN-GAGs). galactosaminoglycuronans 77-101 galanin and GMAP prepropeptide Homo sapiens 103-107 9459305-6 1997 However, senescent HFs produced a greater proportion of PGs containing GlcN-GAG chains and increased the sulphation of the remaining PG fraction with GalN-GAG moieties, yielding a major gain of C6-sulphate groups in the galactosamine residues. Glycosaminoglycans 155-158 galanin and GMAP prepropeptide Homo sapiens 150-154 9854683-0 1998 Influence of galanin and serotonin on the endocrine response to Hexarelin, a synthetic peptidyl GH-secretagogue, in normal women. hexarelin 64-73 galanin and GMAP prepropeptide Homo sapiens 13-20 9854683-7 1998 In group A, the GH response to HEX (1204.2 +/- 312.9 micrograms*min/L) was higher (p < 0.05) than that to GAL alone (305.6 +/- 35.5 micrograms*min/L) and was not modified by GAL co-administration (1021.8 +/- 249.9 micrograms*min/L). hexarelin 31-34 galanin and GMAP prepropeptide Homo sapiens 177-180 9512271-7 1998 In the locus coeruleus (LC), around 80% of the GMAP-positive neurons contained neuropeptide tyrosine (NPY), and about 40% of the NPY-positive neurons expressed GMAP. Tyrosine 92-100 galanin and GMAP prepropeptide Homo sapiens 47-51 9512271-11 1998 The functional role of GAL may be related to noradrenaline, possibly by a presynaptic action. Norepinephrine 45-58 galanin and GMAP prepropeptide Homo sapiens 23-26 9451010-6 1998 Of the monosaccharides studied, the phenylbeta derivatives of Gal were much better inhibitors than the methylbeta derivative, while only an insignificant difference was found between the Galalpha anomer of methyl- and p -NO2-phenyl derivatives. Monosaccharides 7-22 galanin and GMAP prepropeptide Homo sapiens 62-65 9451010-7 1998 From these results, it can be concluded that the combining size of the agglutinin is as large as a disaccharide of the alpha-anomer of Gal at nonreducing end and most complementary to Galalpha1-->6Glc. Disaccharides 99-111 galanin and GMAP prepropeptide Homo sapiens 135-138 9451010-8 1998 As for the combining site of PA-IL toward the beta-anomer, the size is assumed to be less than that of Gal; carbon-6 in the pyranose form is essential, and hydrophobic interaction is important for binding. pa-il 29-34 galanin and GMAP prepropeptide Homo sapiens 103-106 9451010-8 1998 As for the combining site of PA-IL toward the beta-anomer, the size is assumed to be less than that of Gal; carbon-6 in the pyranose form is essential, and hydrophobic interaction is important for binding. carbon-6 108-116 galanin and GMAP prepropeptide Homo sapiens 103-106 9451010-8 1998 As for the combining site of PA-IL toward the beta-anomer, the size is assumed to be less than that of Gal; carbon-6 in the pyranose form is essential, and hydrophobic interaction is important for binding. Pyranose 124-132 galanin and GMAP prepropeptide Homo sapiens 103-106 9275119-1 1997 BACKGROUND: The cell surface carbohydrate moiety, Gal(alpha1,3)Galactose (alphaGal), has been implicated as the major determinant recognized by more than 80% of human anti-porcine natural antibodies (NAb). alpha-D-galactose 74-82 galanin and GMAP prepropeptide Homo sapiens 50-72 9275119-1 1997 BACKGROUND: The cell surface carbohydrate moiety, Gal(alpha1,3)Galactose (alphaGal), has been implicated as the major determinant recognized by more than 80% of human anti-porcine natural antibodies (NAb). nab 200-203 galanin and GMAP prepropeptide Homo sapiens 50-72 9266697-1 1997 Complementary DNA encoding a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase type II (hST3Gal II) was cloned from a CEM T-cell cDNA library using a 23-base oligonucleotide probe. Oligonucleotides 160-175 galanin and GMAP prepropeptide Homo sapiens 35-88 9002184-1 1996 p-Methoxyphenyl (pMP) beta-D-glycopyranosides (Glc, Gal, GlcNPhth, GalNPhth, GlcNTroc, Gal beta 4Glc, Gal alpha 4Gal) were prepared from the corresponding 1-O-acetyl sugars in 79-90% yield, using boron trifluoride etherate as promoter. p-methoxyphenyl (pmp) beta-d-glycopyranosides 0-45 galanin and GMAP prepropeptide Homo sapiens 47-116 9402244-1 1997 The neuropeptide galanin (GAL) is localized in the peripheral and central nervous systems as well as in the adrenal medulla where it coexists with catecholamines. Catecholamines 147-161 galanin and GMAP prepropeptide Homo sapiens 17-24 9402244-1 1997 The neuropeptide galanin (GAL) is localized in the peripheral and central nervous systems as well as in the adrenal medulla where it coexists with catecholamines. Catecholamines 147-161 galanin and GMAP prepropeptide Homo sapiens 26-29 9054470-2 1997 GAL is colocalized with corticotropin (ACTH) in the human pituitary and with epinephrine (E) and norepinephrine (NE) in chromaffin cells of the adrenal medulla. Epinephrine 77-88 galanin and GMAP prepropeptide Homo sapiens 0-3 9054470-2 1997 GAL is colocalized with corticotropin (ACTH) in the human pituitary and with epinephrine (E) and norepinephrine (NE) in chromaffin cells of the adrenal medulla. Norepinephrine 97-111 galanin and GMAP prepropeptide Homo sapiens 0-3 9002184-1 1996 p-Methoxyphenyl (pMP) beta-D-glycopyranosides (Glc, Gal, GlcNPhth, GalNPhth, GlcNTroc, Gal beta 4Glc, Gal alpha 4Gal) were prepared from the corresponding 1-O-acetyl sugars in 79-90% yield, using boron trifluoride etherate as promoter. 1-o-acetyl sugars 155-172 galanin and GMAP prepropeptide Homo sapiens 47-116 9002184-1 1996 p-Methoxyphenyl (pMP) beta-D-glycopyranosides (Glc, Gal, GlcNPhth, GalNPhth, GlcNTroc, Gal beta 4Glc, Gal alpha 4Gal) were prepared from the corresponding 1-O-acetyl sugars in 79-90% yield, using boron trifluoride etherate as promoter. boron trifluoride etherate 196-222 galanin and GMAP prepropeptide Homo sapiens 47-116 8930940-0 1996 Acute administration of human galanin in normal subjects reduces the potentiating effect of pyridostigmine-induced cholinergic enhancement on release of norepinephrine and pancreatic polypeptide. Pyridostigmine Bromide 92-106 galanin and GMAP prepropeptide Homo sapiens 30-37 8930940-0 1996 Acute administration of human galanin in normal subjects reduces the potentiating effect of pyridostigmine-induced cholinergic enhancement on release of norepinephrine and pancreatic polypeptide. Norepinephrine 153-167 galanin and GMAP prepropeptide Homo sapiens 30-37 8930940-1 1996 The neuropeptide galanin (GAL) is widely distributed in the central and peripheral nervous systems where it often coexists with catecholamines and acetylcholine. Catecholamines 128-142 galanin and GMAP prepropeptide Homo sapiens 17-24 8930940-1 1996 The neuropeptide galanin (GAL) is widely distributed in the central and peripheral nervous systems where it often coexists with catecholamines and acetylcholine. Catecholamines 128-142 galanin and GMAP prepropeptide Homo sapiens 26-29 8930940-1 1996 The neuropeptide galanin (GAL) is widely distributed in the central and peripheral nervous systems where it often coexists with catecholamines and acetylcholine. Acetylcholine 147-160 galanin and GMAP prepropeptide Homo sapiens 17-24 8930940-1 1996 The neuropeptide galanin (GAL) is widely distributed in the central and peripheral nervous systems where it often coexists with catecholamines and acetylcholine. Acetylcholine 147-160 galanin and GMAP prepropeptide Homo sapiens 26-29 8930940-2 1996 Recently we have reported that human GAL (hGAL) in man depresses the release of norepinephrine (NE) and the responses to both assumption of upright posture and insulin-induced hypoglycemia. Norepinephrine 80-94 galanin and GMAP prepropeptide Homo sapiens 37-40 8930940-2 1996 Recently we have reported that human GAL (hGAL) in man depresses the release of norepinephrine (NE) and the responses to both assumption of upright posture and insulin-induced hypoglycemia. Norepinephrine 80-94 galanin and GMAP prepropeptide Homo sapiens 42-46 8548058-1 1995 Human galanin (hGAL) is a neuropeptide with 30 amino acid residues that has been found in the peripheral and central nervous system, where it often co-exists with catecholamines. Catecholamines 163-177 galanin and GMAP prepropeptide Homo sapiens 15-19 8702831-2 1996 The kinase is quite specific for GalNAc as the phosphate acceptor and is inactive with GlcNAc, ManNAc, glucose, galactose, mannose, GalN, and GlcN. Phosphates 47-56 galanin and GMAP prepropeptide Homo sapiens 33-37 8702831-2 1996 The kinase is quite specific for GalNAc as the phosphate acceptor and is inactive with GlcNAc, ManNAc, glucose, galactose, mannose, GalN, and GlcN. 2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose 87-93 galanin and GMAP prepropeptide Homo sapiens 33-37 8702831-2 1996 The kinase is quite specific for GalNAc as the phosphate acceptor and is inactive with GlcNAc, ManNAc, glucose, galactose, mannose, GalN, and GlcN. N-acetylmannosamine 95-101 galanin and GMAP prepropeptide Homo sapiens 33-37 8702831-2 1996 The kinase is quite specific for GalNAc as the phosphate acceptor and is inactive with GlcNAc, ManNAc, glucose, galactose, mannose, GalN, and GlcN. Glucose 103-110 galanin and GMAP prepropeptide Homo sapiens 33-37 8702831-2 1996 The kinase is quite specific for GalNAc as the phosphate acceptor and is inactive with GlcNAc, ManNAc, glucose, galactose, mannose, GalN, and GlcN. Galactose 112-121 galanin and GMAP prepropeptide Homo sapiens 33-37 8702831-2 1996 The kinase is quite specific for GalNAc as the phosphate acceptor and is inactive with GlcNAc, ManNAc, glucose, galactose, mannose, GalN, and GlcN. Mannose 123-130 galanin and GMAP prepropeptide Homo sapiens 33-37 8702831-2 1996 The kinase is quite specific for GalNAc as the phosphate acceptor and is inactive with GlcNAc, ManNAc, glucose, galactose, mannose, GalN, and GlcN. Glucosamine 87-91 galanin and GMAP prepropeptide Homo sapiens 33-37 8707864-9 1996 Treatment of IdlD cells with neuraminidase reveals that the sialic acid of the O-linked carbohydrate protects against TfR cleavage, whereas the core sugars Gal-NAc and Gal do not protect as much. Sugars 149-155 galanin and GMAP prepropeptide Homo sapiens 156-159 8706738-2 1996 beta-1,4-Galactosyltransferase (Gal-T, EC 2.4.1.38) transfers galactose (Gal) from UDP-Gal to N-acetyl-D-glucosamine or a derivative GlcNAc-R. Galactose 62-71 galanin and GMAP prepropeptide Homo sapiens 9-12 8706738-2 1996 beta-1,4-Galactosyltransferase (Gal-T, EC 2.4.1.38) transfers galactose (Gal) from UDP-Gal to N-acetyl-D-glucosamine or a derivative GlcNAc-R. Galactose 62-71 galanin and GMAP prepropeptide Homo sapiens 32-35 8706738-2 1996 beta-1,4-Galactosyltransferase (Gal-T, EC 2.4.1.38) transfers galactose (Gal) from UDP-Gal to N-acetyl-D-glucosamine or a derivative GlcNAc-R. Acetylglucosamine 94-116 galanin and GMAP prepropeptide Homo sapiens 9-12 8706738-2 1996 beta-1,4-Galactosyltransferase (Gal-T, EC 2.4.1.38) transfers galactose (Gal) from UDP-Gal to N-acetyl-D-glucosamine or a derivative GlcNAc-R. Acetylglucosamine 94-116 galanin and GMAP prepropeptide Homo sapiens 32-35 8706738-2 1996 beta-1,4-Galactosyltransferase (Gal-T, EC 2.4.1.38) transfers galactose (Gal) from UDP-Gal to N-acetyl-D-glucosamine or a derivative GlcNAc-R. Acetylglucosamine 133-139 galanin and GMAP prepropeptide Homo sapiens 9-12 8706738-2 1996 beta-1,4-Galactosyltransferase (Gal-T, EC 2.4.1.38) transfers galactose (Gal) from UDP-Gal to N-acetyl-D-glucosamine or a derivative GlcNAc-R. Acetylglucosamine 133-139 galanin and GMAP prepropeptide Homo sapiens 32-35 8706738-2 1996 beta-1,4-Galactosyltransferase (Gal-T, EC 2.4.1.38) transfers galactose (Gal) from UDP-Gal to N-acetyl-D-glucosamine or a derivative GlcNAc-R. r 140-141 galanin and GMAP prepropeptide Homo sapiens 9-12 8706738-2 1996 beta-1,4-Galactosyltransferase (Gal-T, EC 2.4.1.38) transfers galactose (Gal) from UDP-Gal to N-acetyl-D-glucosamine or a derivative GlcNAc-R. r 140-141 galanin and GMAP prepropeptide Homo sapiens 32-35 8743965-9 1996 When GAL is used as a marker for this neuronal system, it is clear that estradiol as well as progesterone profoundly affects the message and expression of the peptide and that this regulation, at least in rodents, is neonatally predetermined by gonadal steroid imprinting. Estradiol 72-81 galanin and GMAP prepropeptide Homo sapiens 5-8 8743965-12 1996 Using an immortalized LHRH neuronal cell line (GT1) we have recently observed that these neurons express estrogen receptor (ER) and GAL and that estradiol can increase the expression of GAL, indicating functional activation of the endogenous ER. Estradiol 145-154 galanin and GMAP prepropeptide Homo sapiens 186-189 8820413-0 1996 Fluorescence and Monte Carlo conformational studies of the (1-15) galanin amide fragment. Amides 74-79 galanin and GMAP prepropeptide Homo sapiens 66-73 8820413-10 1996 These findings are in agreement with the results of earlier CD and NMR conformational studies of galanin in water and non-aqueous solvents. Water 108-113 galanin and GMAP prepropeptide Homo sapiens 97-104 8734340-5 1996 RESULTS: Both hGal and rGal contracted the preparations in a concentration-dependent and tetrodotoxin-resistant manner without difference in sensitivity. Tetrodotoxin 89-101 galanin and GMAP prepropeptide Homo sapiens 14-18 8593630-0 1995 Site-directed enzymatic alpha-(1-->3)-L-fucosylation of the tetrasaccharide Gal beta(1-->4)GlcNAc beta(1-->3)Gal beta(1-->4)GlcNAc at the distal N-acetyllactosamine unit. tetrasaccharide 63-78 galanin and GMAP prepropeptide Homo sapiens 79-82 8593630-0 1995 Site-directed enzymatic alpha-(1-->3)-L-fucosylation of the tetrasaccharide Gal beta(1-->4)GlcNAc beta(1-->3)Gal beta(1-->4)GlcNAc at the distal N-acetyllactosamine unit. tetrasaccharide 63-78 galanin and GMAP prepropeptide Homo sapiens 118-121 8593630-0 1995 Site-directed enzymatic alpha-(1-->3)-L-fucosylation of the tetrasaccharide Gal beta(1-->4)GlcNAc beta(1-->3)Gal beta(1-->4)GlcNAc at the distal N-acetyllactosamine unit. 2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose 97-103 galanin and GMAP prepropeptide Homo sapiens 79-82 8593630-0 1995 Site-directed enzymatic alpha-(1-->3)-L-fucosylation of the tetrasaccharide Gal beta(1-->4)GlcNAc beta(1-->3)Gal beta(1-->4)GlcNAc at the distal N-acetyllactosamine unit. 2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose 97-103 galanin and GMAP prepropeptide Homo sapiens 118-121 8593630-0 1995 Site-directed enzymatic alpha-(1-->3)-L-fucosylation of the tetrasaccharide Gal beta(1-->4)GlcNAc beta(1-->3)Gal beta(1-->4)GlcNAc at the distal N-acetyllactosamine unit. 2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose 136-142 galanin and GMAP prepropeptide Homo sapiens 79-82 8593630-0 1995 Site-directed enzymatic alpha-(1-->3)-L-fucosylation of the tetrasaccharide Gal beta(1-->4)GlcNAc beta(1-->3)Gal beta(1-->4)GlcNAc at the distal N-acetyllactosamine unit. N-acetyllactosamine 157-176 galanin and GMAP prepropeptide Homo sapiens 79-82 8548058-3 1995 Human GAL administration significantly reduced both the release of basal norepinephrine and the response to insulin-induced hypoglycemia, whereas it attenuated the epinephrine response by 26%, with the hGAL-induced decrease in epinephrine release failing to achieve statistical significance. Norepinephrine 73-87 galanin and GMAP prepropeptide Homo sapiens 6-9 8548058-3 1995 Human GAL administration significantly reduced both the release of basal norepinephrine and the response to insulin-induced hypoglycemia, whereas it attenuated the epinephrine response by 26%, with the hGAL-induced decrease in epinephrine release failing to achieve statistical significance. Norepinephrine 73-87 galanin and GMAP prepropeptide Homo sapiens 202-206 8548058-3 1995 Human GAL administration significantly reduced both the release of basal norepinephrine and the response to insulin-induced hypoglycemia, whereas it attenuated the epinephrine response by 26%, with the hGAL-induced decrease in epinephrine release failing to achieve statistical significance. Epinephrine 76-87 galanin and GMAP prepropeptide Homo sapiens 6-9 8548058-3 1995 Human GAL administration significantly reduced both the release of basal norepinephrine and the response to insulin-induced hypoglycemia, whereas it attenuated the epinephrine response by 26%, with the hGAL-induced decrease in epinephrine release failing to achieve statistical significance. Epinephrine 164-175 galanin and GMAP prepropeptide Homo sapiens 202-206 8548058-5 1995 We conclude that GAL receptor stimulation exerts an inhibitory effect on basal and insulin-induced hypoglycemia-stimulated release of norepinephrine. Norepinephrine 134-148 galanin and GMAP prepropeptide Homo sapiens 17-20 7539818-0 1995 Human galanin reduces plasma norepinephrine levels in man. Norepinephrine 29-43 galanin and GMAP prepropeptide Homo sapiens 6-13 7588709-0 1995 Construction of stable BHK-21 cells coexpressing human secretory glycoproteins and human Gal(beta 1-4)GlcNAc-R alpha 2,6-sialyltransferase alpha 2,6-linked NeuAc is preferentially attached to the Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)-branch of diantennary oligosaccharides from secreted recombinant beta-trace protein. Oligosaccharides 262-278 galanin and GMAP prepropeptide Homo sapiens 89-161 8570858-0 1995 Differential effects of deltorphin on arginine and galanin-induced growth hormone secretion in healthy man. deltorphin 24-34 galanin and GMAP prepropeptide Homo sapiens 51-58 7539818-1 1995 The neuropeptide galanin (GAL) is widely distributed in the peripheral and central nervous systems, where it often coexists with catecholamines. Catecholamines 129-143 galanin and GMAP prepropeptide Homo sapiens 17-24 7534460-6 1994 Non-hydrolysable guanosine nucleotides potently reduced specific binding of 125-I-labelled hGal by more than 80%. guanosine nucleotides 17-38 galanin and GMAP prepropeptide Homo sapiens 91-95 7539818-1 1995 The neuropeptide galanin (GAL) is widely distributed in the peripheral and central nervous systems, where it often coexists with catecholamines. Catecholamines 129-143 galanin and GMAP prepropeptide Homo sapiens 26-29 7539818-3 1995 hGAL depressed supine plasma NE (0.84 +/- 0.06 vs. 0.33 +/- 0.02 nmol/L) and blunted the NE response to assumption of the UP (1.68 +/- 0.03 vs. 0.44 +/- 0.03 nmol/L), but caused a significant enhancement of the epinephrine response to assumption of the UP (0.22 +/- 0.02 vs. 0.65 +/- 0.06 nmol/L). Epinephrine 211-222 galanin and GMAP prepropeptide Homo sapiens 0-4 7534460-8 1994 Using 3-[(3-cholamidopropyl) dimethylammonio]-2-hydroxy-1-propanesulphonate, hGal receptors were successfully solubilized from human cortical membranes, exhibiting no significant loss of binding affinity. 3-[(3-cholamidopropyl) dimethylammonio]-2-hydroxy-1-propanesulphonate 6-75 galanin and GMAP prepropeptide Homo sapiens 77-81 7534460-10 1994 This putative hGal receptor is glycosylated since its molecular size was reduced after treatment with endoglycosidase F. Receptors bound to 125I-labelled hGal could be specifically adsorbed to wheat germ agglutinin and ricinus communis agglutinin, suggesting that receptor glycosylation involves N-acetyl glucosamine and galactose respectively. Nitrogen 296-297 galanin and GMAP prepropeptide Homo sapiens 14-18 7534460-10 1994 This putative hGal receptor is glycosylated since its molecular size was reduced after treatment with endoglycosidase F. Receptors bound to 125I-labelled hGal could be specifically adsorbed to wheat germ agglutinin and ricinus communis agglutinin, suggesting that receptor glycosylation involves N-acetyl glucosamine and galactose respectively. Nitrogen 296-297 galanin and GMAP prepropeptide Homo sapiens 154-158 7534460-10 1994 This putative hGal receptor is glycosylated since its molecular size was reduced after treatment with endoglycosidase F. Receptors bound to 125I-labelled hGal could be specifically adsorbed to wheat germ agglutinin and ricinus communis agglutinin, suggesting that receptor glycosylation involves N-acetyl glucosamine and galactose respectively. Acetylglucosamine 298-316 galanin and GMAP prepropeptide Homo sapiens 14-18 7534460-10 1994 This putative hGal receptor is glycosylated since its molecular size was reduced after treatment with endoglycosidase F. Receptors bound to 125I-labelled hGal could be specifically adsorbed to wheat germ agglutinin and ricinus communis agglutinin, suggesting that receptor glycosylation involves N-acetyl glucosamine and galactose respectively. Acetylglucosamine 298-316 galanin and GMAP prepropeptide Homo sapiens 154-158 7534460-10 1994 This putative hGal receptor is glycosylated since its molecular size was reduced after treatment with endoglycosidase F. Receptors bound to 125I-labelled hGal could be specifically adsorbed to wheat germ agglutinin and ricinus communis agglutinin, suggesting that receptor glycosylation involves N-acetyl glucosamine and galactose respectively. Galactose 321-330 galanin and GMAP prepropeptide Homo sapiens 14-18 7534460-10 1994 This putative hGal receptor is glycosylated since its molecular size was reduced after treatment with endoglycosidase F. Receptors bound to 125I-labelled hGal could be specifically adsorbed to wheat germ agglutinin and ricinus communis agglutinin, suggesting that receptor glycosylation involves N-acetyl glucosamine and galactose respectively. Galactose 321-330 galanin and GMAP prepropeptide Homo sapiens 154-158 8104224-4 1993 We hypothesized that anti-Gal may bind in vitro to alpha-galactosyl epitopes on xenogeneic TSH receptors (TSHR) and mimic the effect of TSH on xenogeneic thyrocytes. Thyrotropin 91-94 galanin and GMAP prepropeptide Homo sapiens 26-29 7524093-6 1994 Through PVN injection studies with antisense oligonucleotides to Gal mRNA, a dramatic decline in fat ingestion and body weight suggests that endogenous Gal contributes to the natural appetite for fat. Oligonucleotides 45-61 galanin and GMAP prepropeptide Homo sapiens 65-68 7524093-6 1994 Through PVN injection studies with antisense oligonucleotides to Gal mRNA, a dramatic decline in fat ingestion and body weight suggests that endogenous Gal contributes to the natural appetite for fat. Oligonucleotides 45-61 galanin and GMAP prepropeptide Homo sapiens 152-155 7520703-9 1994 In another set of experiments, we found that GAL mRNA levels could be induced more than 10-fold by 20-hr treatment with phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 120-151 galanin and GMAP prepropeptide Homo sapiens 45-48 7520703-9 1994 In another set of experiments, we found that GAL mRNA levels could be induced more than 10-fold by 20-hr treatment with phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 153-156 galanin and GMAP prepropeptide Homo sapiens 45-48 8186551-2 1994 Transitions between predominantly two conformational states were observed for the NeuNAc alpha (2-->3)Gal linkage, consistent with previous observations for this linkage in sialyl-N-acetyllactosamine. sialyl-N-acetyllactosamine 176-202 galanin and GMAP prepropeptide Homo sapiens 105-108 8186551-4 1994 The Fuc alpha(1-->3)GlcNAc and Gal beta (1-->4)GlcNAc linkages, however, showed more restricted flexibility within a single energy well (RMS differences for the time-averaged glycosidic torsion angles, <phi> and <psi>, were 50% lower than for the NeuNAc alpha(2-->3)Gal linkage), and approximate to a rigid conformation. 2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose 53-59 galanin and GMAP prepropeptide Homo sapiens 34-37 8104224-5 1993 Assays performed with porcine thyrocytes have indicated that anti-Gal can mimic in vitro TSH effects in stimulation for cAMP synthesis, 125I uptake, and cell proliferation. Cyclic AMP 120-124 galanin and GMAP prepropeptide Homo sapiens 66-69 7683014-12 1993 We propose the following sequence of sugar addition to the carbohydrate side-chains of gastric glycoproteins: (1) GaNAc (Golgi apparatus cis-side), (2) GlcNAc (Golgi apparatus intermediate face), (3) GalNac or Gal, alpha-L-fucose (Golgi apparatus trans-side). Sugars 37-42 galanin and GMAP prepropeptide Homo sapiens 160-213 7683014-12 1993 We propose the following sequence of sugar addition to the carbohydrate side-chains of gastric glycoproteins: (1) GaNAc (Golgi apparatus cis-side), (2) GlcNAc (Golgi apparatus intermediate face), (3) GalNac or Gal, alpha-L-fucose (Golgi apparatus trans-side). Carbohydrates 59-71 galanin and GMAP prepropeptide Homo sapiens 160-213 7683014-12 1993 We propose the following sequence of sugar addition to the carbohydrate side-chains of gastric glycoproteins: (1) GaNAc (Golgi apparatus cis-side), (2) GlcNAc (Golgi apparatus intermediate face), (3) GalNac or Gal, alpha-L-fucose (Golgi apparatus trans-side). 2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose 152-158 galanin and GMAP prepropeptide Homo sapiens 160-213 1556184-1 1992 One percent of circulating IgG in humans recognizes galactose alpha 1,3 galactose residues (anti-Gal) and is synthesized in response to stimulation by enteric bacteria. galactosyl-(1-3)galactose 52-81 galanin and GMAP prepropeptide Homo sapiens 97-100 21554646-1 1992 Galanin message-associated peptide (GMAP) is a flanking peptide in mammalian preprogalanin located C-terminally of galanin (GAL). preprogalanin 77-90 galanin and GMAP prepropeptide Homo sapiens 0-34 21554646-1 1992 Galanin message-associated peptide (GMAP) is a flanking peptide in mammalian preprogalanin located C-terminally of galanin (GAL). preprogalanin 77-90 galanin and GMAP prepropeptide Homo sapiens 36-40 21554646-1 1992 Galanin message-associated peptide (GMAP) is a flanking peptide in mammalian preprogalanin located C-terminally of galanin (GAL). preprogalanin 77-90 galanin and GMAP prepropeptide Homo sapiens 124-127 21554646-3 1992 A sensitive radioimmunoassay, developed against a species-conserved portion of mammalian GMAP (synthetic porcine GMAP(19-41)amide), was applied to serially diluted blowfly head extracts. Amides 124-129 galanin and GMAP prepropeptide Homo sapiens 89-93 1556184-4 1992 In contrast, when anti-Gal bound to the capsular polysaccharide of a serum sensitive Serratia, #7, it increased ACP killing of this strain. Polysaccharides 49-63 galanin and GMAP prepropeptide Homo sapiens 23-26 1552169-4 1992 Asparagine-linked oligosaccharides containing Gal(beta-1,4) GlcNAc and Man residues were abundant in serous cells. asparagine-linked oligosaccharides 0-34 galanin and GMAP prepropeptide Homo sapiens 46-66 1371452-4 1992 Galanin secretion from median eminence (ME) fragments incubated in vitro increased exponentially with time, whereas GAL release from arcuate nucleus-ME (AN-ME) fragments depicted a secretory profile consisting of an initial exponential rising phase, followed by a plateau phase in which GAL secretion was apparently abolished. an-me 153-158 galanin and GMAP prepropeptide Homo sapiens 116-119 1371452-5 1992 Moreover, preexposure of AN-ME fragments to porcine GAL (pGAL) increased tissue responsiveness to K(+)-induced depolarization, suggesting that pGAL reduced the gain of the system. an-me 25-30 galanin and GMAP prepropeptide Homo sapiens 52-55 1371452-5 1992 Moreover, preexposure of AN-ME fragments to porcine GAL (pGAL) increased tissue responsiveness to K(+)-induced depolarization, suggesting that pGAL reduced the gain of the system. L-Lysine L-glutamate 57-61 galanin and GMAP prepropeptide Homo sapiens 52-55 1371452-5 1992 Moreover, preexposure of AN-ME fragments to porcine GAL (pGAL) increased tissue responsiveness to K(+)-induced depolarization, suggesting that pGAL reduced the gain of the system. L-Lysine L-glutamate 143-147 galanin and GMAP prepropeptide Homo sapiens 52-55 1371452-7 1992 In addition, blockade of GAL biological activity in vivo by administration of a sheep antirat GAL serum increased GAL release from AN-ME fragments in vitro, whereas this treatment did not affect GAL release from ME terminals. Ethanol 131-133 galanin and GMAP prepropeptide Homo sapiens 25-28 1371452-7 1992 In addition, blockade of GAL biological activity in vivo by administration of a sheep antirat GAL serum increased GAL release from AN-ME fragments in vitro, whereas this treatment did not affect GAL release from ME terminals. Ethanol 131-133 galanin and GMAP prepropeptide Homo sapiens 94-97 1371452-7 1992 In addition, blockade of GAL biological activity in vivo by administration of a sheep antirat GAL serum increased GAL release from AN-ME fragments in vitro, whereas this treatment did not affect GAL release from ME terminals. Ethanol 131-133 galanin and GMAP prepropeptide Homo sapiens 94-97 1371452-7 1992 In addition, blockade of GAL biological activity in vivo by administration of a sheep antirat GAL serum increased GAL release from AN-ME fragments in vitro, whereas this treatment did not affect GAL release from ME terminals. Ethanol 131-133 galanin and GMAP prepropeptide Homo sapiens 94-97 1378950-6 1992 However, human GAL showed similar biological activity to the other (amidated) GALs here. cyclohexenoesculetin-beta-galactoside 78-82 galanin and GMAP prepropeptide Homo sapiens 15-18 1371576-2 1992 GAL is also endowed with an inhibiting effect on glucose-stimulated insulin release in animals, but not in man. Glucose 49-56 galanin and GMAP prepropeptide Homo sapiens 0-3 1576211-9 1992 Finally, we observed that the values of the torsional angles of the three linkages: NeuAc(alpha 2-6)Gal(beta 1-), Gal(beta 1-4)GlcNAc(beta 1-) and GlcNAc(beta 1-2)Man(beta 1-) of each of the two antennae were different, demonstrating their asymmetric conformation. N-Acetylneuraminic Acid 84-89 galanin and GMAP prepropeptide Homo sapiens 90-140 1371576-3 1992 We studied the effect of GAL (80 pmol/kg/min infused over 60 minutes) on the arginine- (ARG, 30 g infused over 30 minutes) stimulated GH, PRL, insulin, and C-peptide secretion in eight healthy volunteers (age, 20 to 30 years). Arginine 77-85 galanin and GMAP prepropeptide Homo sapiens 25-28 1371576-4 1992 GAL induced an increase of GH (GAL v saline, area under curve [AUC], mean +/- SEM: 316.5 +/- 73.9 v 93.2 +/- 20.9 micrograms/L/h, P less than .05), but failed to modify both PRL and insulin secretion. Sodium Chloride 37-43 galanin and GMAP prepropeptide Homo sapiens 0-3 1371576-5 1992 GAL enhanced the ARG-induced stimulation of both GH (1,634.1 +/- 293.1 v 566.9 +/- 144.0 micrograms/L/h, P less than .02) and PRL secretion (1,541.9 +/- 248.8 v 1,023.8 +/- 158.7 micrograms/L/h, P less than .02). Arginine 17-20 galanin and GMAP prepropeptide Homo sapiens 0-3 1371576-6 1992 On the contrary, GAL blunted the ARG-stimulated insulin (816.3 +/- 87.7 v 1,322.7 +/- 240.9 mU/L/h, P less than .05), as well as C-peptide secretion (105.1 +/- 9.8 v 132.8 +/- 17.3 micrograms/L/h, P less than .02). Arginine 33-36 galanin and GMAP prepropeptide Homo sapiens 17-20 1371576-9 1992 In conclusion, these results show that in man GAL potentiates the GH response to ARG, suggesting that these drugs act at the hypothalamic level, at least in part, via different mechanisms. Arginine 81-84 galanin and GMAP prepropeptide Homo sapiens 46-49 2079981-1 1990 Increased serum titers of antibodies against the ganglioside GM1 or its carbohydrate epitope Gal(B1-3)GalNAc have been associated with motor neuron disease, motor neuropathies with or without conduction block and sensorimotor neuropathies, whereas low level titers are part of the normal immune repertoire and are present in control groups and in neonatal blood. Gangliosides 49-60 galanin and GMAP prepropeptide Homo sapiens 93-108 1722980-1 1991 Galanin (GAL), a neuropeptide which has been reported to inhibit the evoked release of acetylcholine, is widely distributed in the mammalian central nervous system. Acetylcholine 87-100 galanin and GMAP prepropeptide Homo sapiens 0-7 1722980-1 1991 Galanin (GAL), a neuropeptide which has been reported to inhibit the evoked release of acetylcholine, is widely distributed in the mammalian central nervous system. Acetylcholine 87-100 galanin and GMAP prepropeptide Homo sapiens 9-12 1722333-1 1991 Galanin (Gal), a 29-amino acid C-terminally amidated neuropeptide, is widely distributed throughout the central and peripheral nervous system. 29-amino acid 17-30 galanin and GMAP prepropeptide Homo sapiens 0-7 1722333-1 1991 Galanin (Gal), a 29-amino acid C-terminally amidated neuropeptide, is widely distributed throughout the central and peripheral nervous system. 29-amino acid 17-30 galanin and GMAP prepropeptide Homo sapiens 0-3 1722333-4 1991 The primary structure of hGal was determined by automatic Edman degradation to be Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu- Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr- Ser-COOH. Glycine 82-85 galanin and GMAP prepropeptide Homo sapiens 25-29 1722333-4 1991 The primary structure of hGal was determined by automatic Edman degradation to be Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu- Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr- Ser-COOH. Tryptophan 86-89 galanin and GMAP prepropeptide Homo sapiens 25-29 1722333-4 1991 The primary structure of hGal was determined by automatic Edman degradation to be Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu- Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr- Ser-COOH. Threonine 90-93 galanin and GMAP prepropeptide Homo sapiens 25-29 1722333-4 1991 The primary structure of hGal was determined by automatic Edman degradation to be Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu- Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr- Ser-COOH. Leucine 94-97 galanin and GMAP prepropeptide Homo sapiens 25-29 1722333-4 1991 The primary structure of hGal was determined by automatic Edman degradation to be Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu- Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr- Ser-COOH. Carbonic Acid 204-208 galanin and GMAP prepropeptide Homo sapiens 25-29 1722333-6 1991 Compared to the 29-residue porcine, rat, and bovine Gals, hGal uniquely comprises 30 amino acids possessing an additional nonamidated serine residue as C terminus. Serine 134-140 galanin and GMAP prepropeptide Homo sapiens 58-62 2021640-5 1991 In the case of globoside, where the glycolipid headgroup is equivalent to that of GlcCer extended by three sugar residues, values for the quadrupolar splittings associated with the acyl chain C2-position were very close to those obtained for Gal- and GlcCer. Globosides 15-24 galanin and GMAP prepropeptide Homo sapiens 242-257 34905486-9 2021 The immunohistochemistry results confirmed its multi-functionally chromaffin-like properties with positive staining for CRH, POMC, ACTH, GAL, TH and CgA. chromaffin 66-76 galanin and GMAP prepropeptide Homo sapiens 137-140 1698509-0 1990 Peptide-amine interactions in the hypothalamic paraventricular nucleus: analysis of galanin and neuropeptide Y in relation to feeding. peptide-amine 0-13 galanin and GMAP prepropeptide Homo sapiens 84-91 1698509-1 1990 The neuropeptide galanin (GAL) has been found to elicit feeding after injection into the paraventricular hypothalamic nucleus (PVN), where it coexists with norepinephrine (NE), a neurotransmitter believed to be important in the control of natural feeding behavior. Norepinephrine 156-170 galanin and GMAP prepropeptide Homo sapiens 17-24 1698509-1 1990 The neuropeptide galanin (GAL) has been found to elicit feeding after injection into the paraventricular hypothalamic nucleus (PVN), where it coexists with norepinephrine (NE), a neurotransmitter believed to be important in the control of natural feeding behavior. Norepinephrine 156-170 galanin and GMAP prepropeptide Homo sapiens 26-29 1698509-4 1990 Further, experimentation with the catecholamine synthesis inhibitors, alpha-methyl-p-tyrosine and Fla-63, suggested that GAL"s action also depends upon the release of endogenous NE. Catecholamines 34-47 galanin and GMAP prepropeptide Homo sapiens 121-124 1698509-4 1990 Further, experimentation with the catecholamine synthesis inhibitors, alpha-methyl-p-tyrosine and Fla-63, suggested that GAL"s action also depends upon the release of endogenous NE. alpha-Methyltyrosine 70-93 galanin and GMAP prepropeptide Homo sapiens 121-124 1698509-4 1990 Further, experimentation with the catecholamine synthesis inhibitors, alpha-methyl-p-tyrosine and Fla-63, suggested that GAL"s action also depends upon the release of endogenous NE. Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide 98-104 galanin and GMAP prepropeptide Homo sapiens 121-124 1696375-2 1990 GAL-induced contractions (GAL EC50 = 9 nmol/l) were maximally 25% of those elicited by 10 mumol/l carbamylcholine and remained unaffected by atropine, tetrodotoxin, or tachyphylaxis to substance P. The presynaptic Ca2+ channel blocker, omega-conotoxin (0.1 mumol/l), inhibited GAL-induced contractions by 66%. Carbachol 98-113 galanin and GMAP prepropeptide Homo sapiens 0-3 1699689-8 1990 This observation strengthens the view that the mechanism of action of Gal involves modulation of endogenous somatostatin (SRIH) release. srih 122-126 galanin and GMAP prepropeptide Homo sapiens 70-73 34129898-3 2021 AIM OF THE STUDY: To determine the protective effect of NDD on D-galactosamine/lipopolysaccharide (D-GalN/LPS)-induced ALF and explore the underlying mechanisms. Nordazepam 56-59 galanin and GMAP prepropeptide Homo sapiens 101-105 34546847-0 2021 Protective effects of Schisandrin B against D-GalN-induced cell apoptosis in human hepatocyte (L02) cells via modulating Bcl-2 and Bax. schizandrin B 22-35 galanin and GMAP prepropeptide Homo sapiens 46-50 34546847-9 2021 The results indicated that schisandrin B significantly prevented D-GalN-induced oxidative damage in L02 cells (P<0.05), decreased GSH-Px and SOD activities (P<0.05), increased MDA content (P<0.05). schizandrin B 27-40 galanin and GMAP prepropeptide Homo sapiens 67-71 34546847-10 2021 Furthermore, schisandrin B inhibited D-GalN-induced apoptosis in L02 cells (P<0.05), regulated the expression of Bax and Bcl-2 (P<0.05). schizandrin B 13-26 galanin and GMAP prepropeptide Homo sapiens 39-43 34546847-11 2021 The results indicated that schisandrin B decreased the D-GalN-induced intracellular oxidative stress indexes generation, and inhibited the down-regulation of Bcl-2 and up-regulation of Bax induced by D-GalN. schizandrin B 27-40 galanin and GMAP prepropeptide Homo sapiens 57-61 34546847-11 2021 The results indicated that schisandrin B decreased the D-GalN-induced intracellular oxidative stress indexes generation, and inhibited the down-regulation of Bcl-2 and up-regulation of Bax induced by D-GalN. schizandrin B 27-40 galanin and GMAP prepropeptide Homo sapiens 202-206 34129898-3 2021 AIM OF THE STUDY: To determine the protective effect of NDD on D-galactosamine/lipopolysaccharide (D-GalN/LPS)-induced ALF and explore the underlying mechanisms. Galactosamine 63-78 galanin and GMAP prepropeptide Homo sapiens 101-105 34129898-10 2021 Metabolomic analysis showed that NDD treatment increased the levels of cysteine, decreased those of glutamate, and ameliorated the D-GalN/LPS-induced reduction in the levels of glutathione (GSH). Nordazepam 33-36 galanin and GMAP prepropeptide Homo sapiens 133-137 34129898-10 2021 Metabolomic analysis showed that NDD treatment increased the levels of cysteine, decreased those of glutamate, and ameliorated the D-GalN/LPS-induced reduction in the levels of glutathione (GSH). Glutathione 177-188 galanin and GMAP prepropeptide Homo sapiens 133-137 34129898-10 2021 Metabolomic analysis showed that NDD treatment increased the levels of cysteine, decreased those of glutamate, and ameliorated the D-GalN/LPS-induced reduction in the levels of glutathione (GSH). Glutathione 190-193 galanin and GMAP prepropeptide Homo sapiens 133-137 35149838-6 2022 GLUT1-knockout (-/+) repressed the GAL-mediated increase in CRC cell uptake of glucose, migrate, and invade in vitro, as well as metastasis from the intestine to the liver in vivo, and enforced expression of GLUT1 rescued GAL knockout-induced biological functions in CRC cells. Glucose 79-86 galanin and GMAP prepropeptide Homo sapiens 35-38 2477790-5 1989 When the dose of Gal was increased to 15 micrograms/kg/h the mean plasma GH peak in CGD children (18.5 +/- 3.5 ng/mL) was still higher than in the NS group (13.2 +/- 2.9 ng/mL), although not significantly so. ns 147-149 galanin and GMAP prepropeptide Homo sapiens 17-20