PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
16497670-1	2006	In yeast, the Met4 transcription factor and its cofactors Cbf1, Met28, Met31, and Met32 control the expression of sulfur metabolism and oxidative stress response genes.	Sulfur	114-120	Cbf1p	Saccharomyces cerevisiae S288C	58-62
17479268-11	2007	Finally, we show that the AgMET3 promoter contains two Cpf1-binding sites and that AgCPF1 can complement the S. cerevisiae cpf1 methionine auxotrophy.	Methionine	128-138	Cbf1p	Saccharomyces cerevisiae S288C	123-127
16497670-7	2006	Strains that harbor the Met4-Cbf1 fusion as the only source of Cbf1 activity needed for proper kinetochore function exhibit high rates of methionine-dependent chromosomal instability.	Methionine	138-148	Cbf1p	Saccharomyces cerevisiae S288C	29-33
16497670-7	2006	Strains that harbor the Met4-Cbf1 fusion as the only source of Cbf1 activity needed for proper kinetochore function exhibit high rates of methionine-dependent chromosomal instability.	Methionine	138-148	Cbf1p	Saccharomyces cerevisiae S288C	63-67
15998664-1	2005	MOTIVATION: In yeast, methionine and phosphate metabolism are regulated by the complexes Met4p/Met28p/Cbf1p and Pho4p, respectively.	Methionine	22-32	Cbf1p	Saccharomyces cerevisiae S288C	102-107
15998664-1	2005	MOTIVATION: In yeast, methionine and phosphate metabolism are regulated by the complexes Met4p/Met28p/Cbf1p and Pho4p, respectively.	Phosphates	37-46	Cbf1p	Saccharomyces cerevisiae S288C	102-107
15998664-3	2005	We evaluate our capability to discriminate phosphate- and methionine-responding genes on the basis of putative regulatory elements, despite the similarity between Met4p/Met28p/Cbf1p and Pho4p consensus.	Phosphates	43-52	Cbf1p	Saccharomyces cerevisiae S288C	176-181
15998664-4	2005	RESULTS: We scanned upstream regions of methionine, phosphate and control genes with position-specific weight matrices for Pho4p, Met4p/Met28p/Cbf1p and Met31p/Met32p, and applied discriminant analysis to classify genes according to matrix matching scores.	Methionine	40-50	Cbf1p	Saccharomyces cerevisiae S288C	143-148
11481675-0	2001	The centromere-binding factor Cbf1p from Candida albicans complements the methionine auxotrophic phenotype of Saccharomyces cerevisiae.	Methionine	74-84	Cbf1p	Saccharomyces cerevisiae S288C	30-35
14514673-6	2003	In contrast, the Yap1-mediated effect is unaffected, indicating that Met4 acts via Cbf1 to regulate the Yap1-mediated induction of GSH1 expression in response to glutathione depletion.	Glutathione	162-173	Cbf1p	Saccharomyces cerevisiae S288C	83-87
12820973-4	2003	Cbf1p- and Isw1p-dependent displacement of TBP is also observed at the PHO84 promoter, but not at the ADH1 promoter, where loss of TBP is Cbf1p- and Isw1p independent.	tributyl phosphate	43-46	Cbf1p	Saccharomyces cerevisiae S288C	0-5
12820973-4	2003	Cbf1p- and Isw1p-dependent displacement of TBP is also observed at the PHO84 promoter, but not at the ADH1 promoter, where loss of TBP is Cbf1p- and Isw1p independent.	tributyl phosphate	43-46	Cbf1p	Saccharomyces cerevisiae S288C	138-143
11070082-3	2000	Glutathione S-transferase pull-down experiments showed the direct interaction of in vitro translated p110, p64, and p58 of the essential CBF3 kinetochore protein complex with Cbf1p, a basic region helix-loop-helix zipper protein (bHLHzip) that specifically binds to the CDEI region on the centromere DNA.	Glutathione	0-11	Cbf1p	Saccharomyces cerevisiae S288C	175-180
11222754-6	2001	In addition, native polyacrylamide gel electrophoresis revealed distinct changes in the 3D structure of the Cbf1p/CEN complexes.	polyacrylamide	20-34	Cbf1p	Saccharomyces cerevisiae S288C	108-113
7588747-2	1995	Transcription of the QCR8 gene, encoding subunit VIII of the Saccharomyces cerevisiae mitochondrial ubiquinol-cytochrome c oxidoreductase (QCR), is controlled by the carbon-source-dependent heme-activator protein complex HAP2/3/4 and the general transcriptional regulators autonomous replication-site-binding factor ABF1 and centromere-binding and promoter-binding factor CPF1.	Carbon	166-172	Cbf1p	Saccharomyces cerevisiae S288C	372-376
9799240-1	1998	The transcriptional regulation of the sulfur amino acid pathway in Saccharomyces cerevisiae depends on a single activator, Met4p, whose function requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p.	Amino Acids, Sulfur	38-55	Cbf1p	Saccharomyces cerevisiae S288C	202-207
9409150-9	1997	Situated upstream of the sulfur genes, this element is the binding site of a transcription activation complex consisting of a basic helix-loop-helix factor, Cbf1p, and two basic leucine zipper factors, Met4p and Met28p.	Sulfur	25-31	Cbf1p	Saccharomyces cerevisiae S288C	157-162
8674545-4	1996	The enhanced transcription was dependent on the CBF1 gene, but did not compete with an excess of wild-type Met4p, suggesting that some changes in the affinity of Met4p to other factors might be involved in S-adenosylmethionine-mediated transcriptional regulation.	S-Adenosylmethionine	208-226	Cbf1p	Saccharomyces cerevisiae S288C	48-52
7588747-8	1995	The repressive action of the negative modulator CPF1 during escape from glucose repression is overcome through the cooperative action of ABF1 and HAP2/3/4.	Glucose	72-79	Cbf1p	Saccharomyces cerevisiae S288C	48-52
8035802-1	1994	CPF1 is an abundant basic-helix-loop-helix-ZIP protein that binds to the CDEI motif in Saccharomyces cerevisiae centromeres and in the promoters of numerous genes, including those encoding enzymes of the methionine biosynthetic pathway.	Methionine	204-214	Cbf1p	Saccharomyces cerevisiae S288C	0-4
7601277-2	1995	Phenotypic studies of cells lacking Cbf1 revealed that this factor is actually involved in two cellular processes; the fidelity of the chromosomal segregation and the metabolism of sulfur amino acids.	Amino Acids, Sulfur	181-199	Cbf1p	Saccharomyces cerevisiae S288C	36-40
7601277-3	1995	However, the function of Cbf1 in the regulation of the sulfur amino acid metabolism is now a matter of controversy in literature with conflicting reports about its binding to the CACGTG sequences found upstream to the methionine biosynthetic genes.	Amino Acids, Sulfur	55-72	Cbf1p	Saccharomyces cerevisiae S288C	25-29
7601277-3	1995	However, the function of Cbf1 in the regulation of the sulfur amino acid metabolism is now a matter of controversy in literature with conflicting reports about its binding to the CACGTG sequences found upstream to the methionine biosynthetic genes.	Methionine	218-228	Cbf1p	Saccharomyces cerevisiae S288C	25-29
7601277-4	1995	To provide a reliable basis for the functional analysis of Cbf1, we present an analysis of the transcription of the methionine biosynthesic genes in cells lacking Cbf1.	Methionine	116-126	Cbf1p	Saccharomyces cerevisiae S288C	59-63
7601277-5	1995	Our results prove that Cbf1 is indeed involved in the transcriptional regulation of the sulfur amino acid metabolism.	Amino Acids, Sulfur	88-105	Cbf1p	Saccharomyces cerevisiae S288C	23-27
7891681-0	1995	Role of the Saccharomyces cerevisiae general regulatory factor CP1 in methionine biosynthetic gene transcription.	Methionine	70-80	Cbf1p	Saccharomyces cerevisiae S288C	63-66
7891681-1	1995	Saccharomyces cerevisiae general regulatory factor CP1 (encoded by the gene CEP1) is required for optimal chromosome segregation and methionine prototrophy.	Methionine	133-143	Cbf1p	Saccharomyces cerevisiae S288C	51-54
7891681-1	1995	Saccharomyces cerevisiae general regulatory factor CP1 (encoded by the gene CEP1) is required for optimal chromosome segregation and methionine prototrophy.	Methionine	133-143	Cbf1p	Saccharomyces cerevisiae S288C	76-80
7891681-3	1995	Activity of the UAS required an intact CP1-binding site, and the effects of cis-acting mutations on CP1 binding and UAS activity correlated.	Phenindione	16-19	Cbf1p	Saccharomyces cerevisiae S288C	39-42
7891681-3	1995	Activity of the UAS required an intact CP1-binding site, and the effects of cis-acting mutations on CP1 binding and UAS activity correlated.	Phenindione	16-19	Cbf1p	Saccharomyces cerevisiae S288C	100-103
7859301-1	1994	The KlCPF1 gene, coding for the centromere and promoter factor CPF1 from Kluyveromyces lactis, has been cloned by functional complementation of the methionine auxotrophic phenotype of a Saccharomyces cerevisiae mutant lacking ScCPF1.	Methionine	148-158	Cbf1p	Saccharomyces cerevisiae S288C	6-10
7859301-6	1994	In-vitro mobility-shift experiments were used to establish that both CPF1 proteins bind to the consensus binding site RTCACRTG (CDEI element).	cdei	128-132	Cbf1p	Saccharomyces cerevisiae S288C	69-73
8035802-2	1994	Strains lacking CPF1 are methionine auxotrophs, and it has been proposed that CPF1 might positively influence transcription at the MET25 and MET16 genes by modulating promoter chromatin structure.	Methionine	25-35	Cbf1p	Saccharomyces cerevisiae S288C	16-20
8052535-3	1994	We show that the minimal length of the Cpf1 binding site needed for full in vitro binding and in vivo activity is 10 base pairs long comprised of CDEI plus the two base pairs 3" of this sequence.	cdei	146-150	Cbf1p	Saccharomyces cerevisiae S288C	39-43
1398064-2	1992	Strains lacking CP1 exhibit defects in growth, chromosome segregation and methionine biosynthesis.	Methionine	74-84	Cbf1p	Saccharomyces cerevisiae S288C	16-19
8413187-1	1993	In Saccharomyces cerevisiae, the CPF1 gene encodes a centromere binding protein that also plays a role in transcription; cpf1 strains are methionine auxotrophs.	Methionine	138-148	Cbf1p	Saccharomyces cerevisiae S288C	33-37
8413187-1	1993	In Saccharomyces cerevisiae, the CPF1 gene encodes a centromere binding protein that also plays a role in transcription; cpf1 strains are methionine auxotrophs.	Methionine	138-148	Cbf1p	Saccharomyces cerevisiae S288C	121-125
8243994-2	1993	Deletion of the gene encoding Cbf1p results in an increased frequency of chromosome loss, hypersensitivity to low levels of microtubule disrupting drugs (such as thiabendazole and benomyl) and methionine auxotrophy.	Thiabendazole	162-175	Cbf1p	Saccharomyces cerevisiae S288C	30-35
8243994-2	1993	Deletion of the gene encoding Cbf1p results in an increased frequency of chromosome loss, hypersensitivity to low levels of microtubule disrupting drugs (such as thiabendazole and benomyl) and methionine auxotrophy.	Benomyl	180-187	Cbf1p	Saccharomyces cerevisiae S288C	30-35
8243994-2	1993	Deletion of the gene encoding Cbf1p results in an increased frequency of chromosome loss, hypersensitivity to low levels of microtubule disrupting drugs (such as thiabendazole and benomyl) and methionine auxotrophy.	Methionine	193-203	Cbf1p	Saccharomyces cerevisiae S288C	30-35
1398064-3	1992	A YEp24-based yeast genomic library was screened for plasmids which suppressed the methionine auxotrophy of a cep1 null mutant.	Methionine	83-93	Cbf1p	Saccharomyces cerevisiae S288C	110-114
1398064-6	1992	PHO4c, pho80 and pho84 mutations, all of which lead to constitutive activation of the PHO4 transcription factor, also suppressed cep1 methionine auxotrophy.	pho4c	0-5	Cbf1p	Saccharomyces cerevisiae S288C	129-133
1398064-6	1992	PHO4c, pho80 and pho84 mutations, all of which lead to constitutive activation of the PHO4 transcription factor, also suppressed cep1 methionine auxotrophy.	Methionine	134-144	Cbf1p	Saccharomyces cerevisiae S288C	129-133
1398064-8	1992	Spontaneously arising extragenic suppressors of cep1 methionine auxotrophy were also isolated; approximately one-third of them were alleles of pho80.	Methionine	53-63	Cbf1p	Saccharomyces cerevisiae S288C	48-52
1508716-1	1992	CPF1 is a basic helix-loop-helix (bHLH) protein required for optimal centromere function and for maintaining methionine independent growth in yeast.	Methionine	109-119	Cbf1p	Saccharomyces cerevisiae S288C	0-4
1508716-6	1992	The C-terminal domain of CPF1 can be replaced by the leucine repeat region of the bHLH-ZIP protein USF and the hybrid CPF1-USF protein functions in vivo to provide normal centromere function and methionine independent growth.	Methionine	195-205	Cbf1p	Saccharomyces cerevisiae S288C	25-29
1508716-6	1992	The C-terminal domain of CPF1 can be replaced by the leucine repeat region of the bHLH-ZIP protein USF and the hybrid CPF1-USF protein functions in vivo to provide normal centromere function and methionine independent growth.	Methionine	195-205	Cbf1p	Saccharomyces cerevisiae S288C	118-122
33724418-4	2021	We found that in C. albicans, the Met4 ortholog is also a core regulator of methionine biosynthesis, where it functions together with Cbf1.	Methionine	76-86	Cbf1p	Saccharomyces cerevisiae S288C	134-138
1731330-2	1992	The yeast bHLH protein CBF1 binds to the sequence CAC(A/G)TG found in the yeast centromere element CDE1 and in promoter regions of several yeast genes involved in methionine biosynthesis.	Methionine	163-173	Cbf1p	Saccharomyces cerevisiae S288C	23-27
1731330-3	1992	Using a functional assay to rescue a mutant cbf1 yeast strain from methionine auxotrophy, we determined that the basic region of CBF1 could be replaced by the homologous region of either the vertebrate USF transcription factor or c-Myc, both of which bind CACGTG.	Methionine	67-77	Cbf1p	Saccharomyces cerevisiae S288C	44-48
1731330-3	1992	Using a functional assay to rescue a mutant cbf1 yeast strain from methionine auxotrophy, we determined that the basic region of CBF1 could be replaced by the homologous region of either the vertebrate USF transcription factor or c-Myc, both of which bind CACGTG.	Methionine	67-77	Cbf1p	Saccharomyces cerevisiae S288C	129-133
1731330-3	1992	Using a functional assay to rescue a mutant cbf1 yeast strain from methionine auxotrophy, we determined that the basic region of CBF1 could be replaced by the homologous region of either the vertebrate USF transcription factor or c-Myc, both of which bind CACGTG.	cacgtg	256-262	Cbf1p	Saccharomyces cerevisiae S288C	129-133
1731330-5	1992	However, only a single substitution, Met----Arg, in the AP4 basic region of the inactive chimera CBF-AP4 was sufficient to restore CBF1 function.	met----arg	37-47	Cbf1p	Saccharomyces cerevisiae S288C	131-135
2185892-0	1990	Yeast centromere binding protein CBF1, of the helix-loop-helix protein family, is required for chromosome stability and methionine prototrophy.	Methionine	120-130	Cbf1p	Saccharomyces cerevisiae S288C	33-37
2185892-4	1990	Disruption of the CBF1 gene caused a decrease in the growth rate, an increase in the rate of chromosome loss/nondisjunction, and hypersensitivity to the antimitotic drug thiabendazole.	Thiabendazole	170-183	Cbf1p	Saccharomyces cerevisiae S288C	18-22
2185892-5	1990	Unexpectedly, the cbf1 null mutation concomitantly resulted in a methionine auxotrophic phenotype, which suggests that CBF1, like other HLH proteins in higher eukaryotic cells, participates in the regulation of gene expression.	Methionine	65-75	Cbf1p	Saccharomyces cerevisiae S288C	18-22
2185892-5	1990	Unexpectedly, the cbf1 null mutation concomitantly resulted in a methionine auxotrophic phenotype, which suggests that CBF1, like other HLH proteins in higher eukaryotic cells, participates in the regulation of gene expression.	Methionine	65-75	Cbf1p	Saccharomyces cerevisiae S288C	119-123
33724418-7	2021	Therefore, while S. cerevisiae and C. albicans share Cbf1 and Met4 as central elements of the methionine biosynthesis control, the other proteins that make up the circuit in S. cerevisiae are not members of the C. albicans control network, and so the S. cerevisiae circuit likely represents a recently evolved arrangement.	Methionine	94-104	Cbf1p	Saccharomyces cerevisiae S288C	53-57
21700227-5	2011	At nucleosome-depleted sites, competition from another transcription factor, Cbf1, determines Pho4 occupancy, raising the threshold for transcriptional activation in phosphate replete conditions and preventing Pho4 activation of genes outside the phosphate regulon during phosphate starvation.	Phosphates	166-175	Cbf1p	Saccharomyces cerevisiae S288C	77-81
29588420-6	2018	By systematically comparing estimates of binding energies output by deep neural networks (NNs) and biophysical models trained on these data, we establish that dinucleotide (DN) specificities are sufficient to explain essentially all variance in observed binding behavior, with Cbf1 binding exhibiting significantly more nonadditivity than Pho4.	Dinucleoside Phosphates	159-171	Cbf1p	Saccharomyces cerevisiae S288C	277-281
29588420-6	2018	By systematically comparing estimates of binding energies output by deep neural networks (NNs) and biophysical models trained on these data, we establish that dinucleotide (DN) specificities are sufficient to explain essentially all variance in observed binding behavior, with Cbf1 binding exhibiting significantly more nonadditivity than Pho4.	Dinucleoside Phosphates	173-175	Cbf1p	Saccharomyces cerevisiae S288C	277-281
22696679-2	2012	Regulation of the methionine biosynthetic pathway involves three DNA-binding proteins-Met31p, Met32p, and Cbf1p.	Methionine	18-28	Cbf1p	Saccharomyces cerevisiae S288C	106-111
22696683-1	2012	In yeast, the pathways of sulfur assimilation are combinatorially controlled by five transcriptional regulators (three DNA-binding proteins [Met31p, Met32p, and Cbf1p], an activator [Met4p], and a cofactor [Met28p]) and a ubiquitin ligase subunit (Met30p).	Sulfur	26-32	Cbf1p	Saccharomyces cerevisiae S288C	161-166
31867213-4	2020	To demonstrate the utility of CRISPR-Cpf1, we have optimized the CRISPR-Cpf1 system and achieved high-editing efficiency for two counter-selectable markers in the industrially-relevant oleaginous yeast Yarrowia lipolytica: arginine permease (93% for CAN1) and orotidine 5"-phosphate decarboxylase (~96% for URA3).	Arginine Vasopressin	223-231	Cbf1p	Saccharomyces cerevisiae S288C	37-41
31867213-4	2020	To demonstrate the utility of CRISPR-Cpf1, we have optimized the CRISPR-Cpf1 system and achieved high-editing efficiency for two counter-selectable markers in the industrially-relevant oleaginous yeast Yarrowia lipolytica: arginine permease (93% for CAN1) and orotidine 5"-phosphate decarboxylase (~96% for URA3).	Arginine Vasopressin	223-231	Cbf1p	Saccharomyces cerevisiae S288C	72-76
31867213-4	2020	To demonstrate the utility of CRISPR-Cpf1, we have optimized the CRISPR-Cpf1 system and achieved high-editing efficiency for two counter-selectable markers in the industrially-relevant oleaginous yeast Yarrowia lipolytica: arginine permease (93% for CAN1) and orotidine 5"-phosphate decarboxylase (~96% for URA3).	orotidine	260-282	Cbf1p	Saccharomyces cerevisiae S288C	37-41
22146299-4	2011	We report that genes responding to the TF Cbf1 and cofactor Met28 contain a novel "recruitment motif" (RYAAT), adjacent to Cbf1 binding sites, which enhances the binding of a Met4-Met28-Cbf1 regulatory complex, and that abrogation of this motif significantly reduces gene induction under low-sulfur conditions.	Sulfur	292-298	Cbf1p	Saccharomyces cerevisiae S288C	42-46
22146299-4	2011	We report that genes responding to the TF Cbf1 and cofactor Met28 contain a novel "recruitment motif" (RYAAT), adjacent to Cbf1 binding sites, which enhances the binding of a Met4-Met28-Cbf1 regulatory complex, and that abrogation of this motif significantly reduces gene induction under low-sulfur conditions.	Sulfur	292-298	Cbf1p	Saccharomyces cerevisiae S288C	123-127
22146299-4	2011	We report that genes responding to the TF Cbf1 and cofactor Met28 contain a novel "recruitment motif" (RYAAT), adjacent to Cbf1 binding sites, which enhances the binding of a Met4-Met28-Cbf1 regulatory complex, and that abrogation of this motif significantly reduces gene induction under low-sulfur conditions.	Sulfur	292-298	Cbf1p	Saccharomyces cerevisiae S288C	123-127
22146299-6	2011	Finally, we demonstrate that the presence of an RYAAT motif next to a Cbf1 site, rather than Cbf1 binding affinity, specifies Cbf1-dependent sulfur metabolism genes.	Sulfur	141-147	Cbf1p	Saccharomyces cerevisiae S288C	70-74
22146299-6	2011	Finally, we demonstrate that the presence of an RYAAT motif next to a Cbf1 site, rather than Cbf1 binding affinity, specifies Cbf1-dependent sulfur metabolism genes.	Sulfur	141-147	Cbf1p	Saccharomyces cerevisiae S288C	93-97
22146299-6	2011	Finally, we demonstrate that the presence of an RYAAT motif next to a Cbf1 site, rather than Cbf1 binding affinity, specifies Cbf1-dependent sulfur metabolism genes.	Sulfur	141-147	Cbf1p	Saccharomyces cerevisiae S288C	93-97
21700227-5	2011	At nucleosome-depleted sites, competition from another transcription factor, Cbf1, determines Pho4 occupancy, raising the threshold for transcriptional activation in phosphate replete conditions and preventing Pho4 activation of genes outside the phosphate regulon during phosphate starvation.	Phosphates	247-256	Cbf1p	Saccharomyces cerevisiae S288C	77-81
21700227-5	2011	At nucleosome-depleted sites, competition from another transcription factor, Cbf1, determines Pho4 occupancy, raising the threshold for transcriptional activation in phosphate replete conditions and preventing Pho4 activation of genes outside the phosphate regulon during phosphate starvation.	Phosphates	247-256	Cbf1p	Saccharomyces cerevisiae S288C	77-81
20392822-4	2010	Study of Cbf1 and Met31/32 association with PDC6 allowed us to find a new mechanism of recruitment of Met4, which allows PDC6 being differentially regulated compared to sulfur amino acid biosynthetic genes.	Amino Acids, Sulfur	169-186	Cbf1p	Saccharomyces cerevisiae S288C	9-13
19940020-6	2010	Deletion of both Met31 and Met32 eliminated activation of the core regulon, whereas loss of Met28 or Cbf1 interfered with only a subset of targets that map to distinct sectors of the sulfur metabolic network.	Sulfur	183-189	Cbf1p	Saccharomyces cerevisiae S288C	101-105