PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
28652304-6	2017	Bim deficiency rescued IELp development in RasGRP1-/- mice, suggesting that RasGRP1 functions to promote survival during IELp generation.	bim	0-3	RAS guanyl releasing protein 1	Mus musculus	43-50
28652304-6	2017	Bim deficiency rescued IELp development in RasGRP1-/- mice, suggesting that RasGRP1 functions to promote survival during IELp generation.	bim	0-3	RAS guanyl releasing protein 1	Mus musculus	76-83
24336796-2	2013	Here we analyze a new mouse missense variant, Rasgrp1(Anaef), with an ENU-mutated EF hand in the Rasgrp1 Ras guanine nucleotide exchange factor.	Guanine Nucleotides	109-127	RAS guanyl releasing protein 1	Mus musculus	46-53
27902448-0	2016	RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum.	Amphetamine	17-28	RAS guanyl releasing protein 1	Mus musculus	0-7
24464785-5	2014	The dependency on RasGRP1 was associated with a diminished response to the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Phorbol Esters	75-88	RAS guanyl releasing protein 1	Mus musculus	18-25
24464785-5	2014	The dependency on RasGRP1 was associated with a diminished response to the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	104-140	RAS guanyl releasing protein 1	Mus musculus	18-25
24464785-5	2014	The dependency on RasGRP1 was associated with a diminished response to the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	142-145	RAS guanyl releasing protein 1	Mus musculus	18-25
24464785-7	2014	Using a keratinocyte cell line that carries a ras oncogenic mutation, we also demonstrated that RasGRP1 could further activate Ras in response to TPA.	Tetradecanoylphorbol Acetate	146-149	RAS guanyl releasing protein 1	Mus musculus	96-103
24336796-2	2013	Here we analyze a new mouse missense variant, Rasgrp1(Anaef), with an ENU-mutated EF hand in the Rasgrp1 Ras guanine nucleotide exchange factor.	Guanine Nucleotides	109-127	RAS guanyl releasing protein 1	Mus musculus	97-104
24744772-1	2013	RasGRP proteins are activators of Ras and other related small GTPases by the virtue of functioning as guanine nucleotide exchange factors (GEFs).	Guanine Nucleotides	102-120	RAS guanyl releasing protein 1	Mus musculus	0-6
22262848-1	2012	The RasGRP (Ras guanine nucleotide-releasing protein) family proteins are guanine nucleotide exchange factors that activate Ras GTPases, ultimately leading to MAPK activation and many cellular processes.	Guanine Nucleotides	16-34	RAS guanyl releasing protein 1	Mus musculus	4-10
22116551-6	2012	Accordingly, Ba/F3 cells transduced with RasGRP1 survived longer under growth factor withdrawal or phorbol ester stimulation than those transduced with RasGRP4, presumably due to the efficient activation of Ras.	Phorbol Esters	99-112	RAS guanyl releasing protein 1	Mus musculus	41-48
20308057-2	2010	Recently, we demonstrated a role for RasGRP1 in skin carcinogenesis and suggested its participation in the action of tumor-promoting phorbol esters like 12-O-tetradecanoylphorbol-13-acetate (TPA) on Ras pathways in epidermal cells.	Tetradecanoylphorbol Acetate	153-189	RAS guanyl releasing protein 1	Mus musculus	37-44
22719950-8	2012	While the DAG-binding C1 domain of RasGRP1 has long been recognized as an important factor mediating Erk activation, we have revealed the physiological relevance of the tail domain in RasGRP1 function and control of Erk signaling.	dag	10-13	RAS guanyl releasing protein 1	Mus musculus	35-42
21441934-3	2011	This pathway required protein kinase C-delta (PKC-delta) and the guanine nucleotide-exchange factor RasGRP and depended on the concentration of the Ca(2+) sensor STIM1, which controls the magnitude of Ca(2+) entry.	Guanine Nucleotides	65-83	RAS guanyl releasing protein 1	Mus musculus	100-106
20308057-0	2010	RasGRP1 is essential for ras activation by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in epidermal keratinocytes.	Tetradecanoylphorbol Acetate	62-98	RAS guanyl releasing protein 1	Mus musculus	0-7
20308057-2	2010	Recently, we demonstrated a role for RasGRP1 in skin carcinogenesis and suggested its participation in the action of tumor-promoting phorbol esters like 12-O-tetradecanoylphorbol-13-acetate (TPA) on Ras pathways in epidermal cells.	Tetradecanoylphorbol Acetate	191-194	RAS guanyl releasing protein 1	Mus musculus	37-44
20308057-1	2010	RasGRP1 is a guanine nucleotide exchange factor for Ras that binds with high affinity to diacylglycerol analogs like the phorbol esters.	Diglycerides	89-103	RAS guanyl releasing protein 1	Mus musculus	0-7
20308057-1	2010	RasGRP1 is a guanine nucleotide exchange factor for Ras that binds with high affinity to diacylglycerol analogs like the phorbol esters.	Phorbol Esters	121-135	RAS guanyl releasing protein 1	Mus musculus	0-7
20308057-4	2010	In contrast to the effect seen in wild type keratinocytes, Ras(GTP) levels were barely detected in RasGRP1 KO cells even after 60 min of exposure to phorbol esters.	Radium	59-62	RAS guanyl releasing protein 1	Mus musculus	99-106
20308057-2	2010	Recently, we demonstrated a role for RasGRP1 in skin carcinogenesis and suggested its participation in the action of tumor-promoting phorbol esters like 12-O-tetradecanoylphorbol-13-acetate (TPA) on Ras pathways in epidermal cells.	Phorbol Esters	133-147	RAS guanyl releasing protein 1	Mus musculus	37-44
20308057-6	2010	Furthermore, small hairpin RNA-induced silencing of RasGRP1 abrogated the effect of TPA on Ras.	Tetradecanoylphorbol Acetate	84-87	RAS guanyl releasing protein 1	Mus musculus	52-59
20308057-7	2010	Analysis of Ras isoforms showed that both H-Ras and N-Ras depended on RasGRP1 for activation by TPA, whereas activation of K-Ras could not be detected.	Tetradecanoylphorbol Acetate	96-99	RAS guanyl releasing protein 1	Mus musculus	70-77
20308057-9	2010	Notably, TPA-induced phosphorylation of JNK2, but not JNK1, was reduced by RasGRP1 depletion.	Tetradecanoylphorbol Acetate	9-12	RAS guanyl releasing protein 1	Mus musculus	75-82
20308057-10	2010	These data identify RasGRP1 as a critical molecule in the activation of Ras by TPA in primary mouse keratinocytes and suggest JNK2 as one of the relevant downstream targets.	Tetradecanoylphorbol Acetate	79-82	RAS guanyl releasing protein 1	Mus musculus	20-27
17923690-2	2007	The stimulation of this GTPase in T cells occurs primarily through the Vav1- and phospholipase C-gamma1-dependent activation of RasGRP1, a diacylglycerol-responsive Ras GDP/GTP exchange factor.	Diglycerides	139-153	RAS guanyl releasing protein 1	Mus musculus	128-135
17923690-2	2007	The stimulation of this GTPase in T cells occurs primarily through the Vav1- and phospholipase C-gamma1-dependent activation of RasGRP1, a diacylglycerol-responsive Ras GDP/GTP exchange factor.	Guanosine Triphosphate	24-27	RAS guanyl releasing protein 1	Mus musculus	128-135
17974959-1	2007	RasGRP1 is a guanine nucleotide exchange factor for Ras, activated in response to the second messenger diacylglycerol and its ultrapotent analogues, the phorbol esters.	Diglycerides	103-117	RAS guanyl releasing protein 1	Mus musculus	0-7
17974959-1	2007	RasGRP1 is a guanine nucleotide exchange factor for Ras, activated in response to the second messenger diacylglycerol and its ultrapotent analogues, the phorbol esters.	Phorbol Esters	153-167	RAS guanyl releasing protein 1	Mus musculus	0-7
17974959-6	2007	Additionally, 30% of the transgenic mice developed tumors in the absence of initiation, suggesting that RasGRP1 overexpression could partially substitute for the initiation step induced by dimethylbenz(a)anthracene.	anthracene	204-214	RAS guanyl releasing protein 1	Mus musculus	104-111
17974959-7	2007	In primary keratinocytes isolated from K5.RasGRP1 mice, TPA stimulation induced higher levels of Ras activation compared with the levels measured in the wild-type cells, indicating that constitutive overexpression of RasGRP1 in epidermal cells leads to elevated biochemical activation of endogenous Ras in response to TPA.	Tetradecanoylphorbol Acetate	56-59	RAS guanyl releasing protein 1	Mus musculus	42-49
17974959-7	2007	In primary keratinocytes isolated from K5.RasGRP1 mice, TPA stimulation induced higher levels of Ras activation compared with the levels measured in the wild-type cells, indicating that constitutive overexpression of RasGRP1 in epidermal cells leads to elevated biochemical activation of endogenous Ras in response to TPA.	Tetradecanoylphorbol Acetate	56-59	RAS guanyl releasing protein 1	Mus musculus	217-224
17974959-7	2007	In primary keratinocytes isolated from K5.RasGRP1 mice, TPA stimulation induced higher levels of Ras activation compared with the levels measured in the wild-type cells, indicating that constitutive overexpression of RasGRP1 in epidermal cells leads to elevated biochemical activation of endogenous Ras in response to TPA.	Tetradecanoylphorbol Acetate	318-321	RAS guanyl releasing protein 1	Mus musculus	217-224
17065239-0	2007	RasGRP1 confers the phorbol ester-sensitive phenotype to EL4 lymphoma cells.	Phorbol Esters	20-33	RAS guanyl releasing protein 1	Mus musculus	0-7
17210708-1	2007	RasGRP1 is a guanine nucleotide exchange factor for Ras and a receptor of the second messenger diacylglycerol and its ultrapotent analogues, the phorbol esters.	Diglycerides	95-109	RAS guanyl releasing protein 1	Mus musculus	0-7
17210708-1	2007	RasGRP1 is a guanine nucleotide exchange factor for Ras and a receptor of the second messenger diacylglycerol and its ultrapotent analogues, the phorbol esters.	Phorbol Esters	145-159	RAS guanyl releasing protein 1	Mus musculus	0-7
17210708-2	2007	We have recently shown expression of RasGRP1 in the epidermal keratinocytes where it can mediate Ras activation in response to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate, a well-known mouse skin tumor promoter.	Phorbol Esters	131-144	RAS guanyl releasing protein 1	Mus musculus	37-44
17210708-2	2007	We have recently shown expression of RasGRP1 in the epidermal keratinocytes where it can mediate Ras activation in response to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate, a well-known mouse skin tumor promoter.	Tetradecanoylphorbol Acetate	145-181	RAS guanyl releasing protein 1	Mus musculus	37-44
16546974-8	2006	In addition, TPA led to a concentration-dependent down-regulation of RasGRP1, whereas bryostatin 1 failed to induce full RasGRP1 down-regulation.	Tetradecanoylphorbol Acetate	13-16	RAS guanyl releasing protein 1	Mus musculus	69-76
16546974-0	2006	Differential effects of bryostatin 1 and 12-O-tetradecanoylphorbol-13-acetate on the regulation and activation of RasGRP1 in mouse epidermal keratinocytes.	bryostatin 1	24-36	RAS guanyl releasing protein 1	Mus musculus	114-121
16546974-10	2006	The results presented here suggest the possibility that a differential modulation of RasGRP1 by bryostatin 1 compared with TPA could participate in the disparate responses of the epidermal cells to both DAG analogues.	bryostatin 1	96-108	RAS guanyl releasing protein 1	Mus musculus	85-92
16546974-0	2006	Differential effects of bryostatin 1 and 12-O-tetradecanoylphorbol-13-acetate on the regulation and activation of RasGRP1 in mouse epidermal keratinocytes.	Tetradecanoylphorbol Acetate	41-77	RAS guanyl releasing protein 1	Mus musculus	114-121
16546974-10	2006	The results presented here suggest the possibility that a differential modulation of RasGRP1 by bryostatin 1 compared with TPA could participate in the disparate responses of the epidermal cells to both DAG analogues.	Diglycerides	203-206	RAS guanyl releasing protein 1	Mus musculus	85-92
16546974-5	2006	We recently reported that the novel DAG receptor RasGRP1 is expressed in mouse keratinocytes and mediates TPA-induced Ras activation.	Tetradecanoylphorbol Acetate	106-109	RAS guanyl releasing protein 1	Mus musculus	49-56
16546974-7	2006	We found that whereas TPA induced translocation of RasGRP1 to both the plasma and internal membranes of the keratinocytes, bryostatin 1 recruited RasGRP1 only to internal membranes and the nuclear envelope.	Tetradecanoylphorbol Acetate	22-25	RAS guanyl releasing protein 1	Mus musculus	51-58
15588099-0	2004	Synthetic bryostatin analogues activate the RasGRP1 signaling pathway.	Bryostatins	10-20	RAS guanyl releasing protein 1	Mus musculus	44-51
15588099-5	2004	DAG analogues promptly recruited RasGRP1 to cell membranes, but they did not induce RasGRP1 proteolysis.	Diglycerides	0-3	RAS guanyl releasing protein 1	Mus musculus	33-40
14532295-0	2003	RasGRP1 represents a novel non-protein kinase C phorbol ester signaling pathway in mouse epidermal keratinocytes.	Phorbol Esters	48-61	RAS guanyl releasing protein 1	Mus musculus	0-7
14532295-5	2003	Overexpression of RasGRP1 in keratinocytes increased the level of active GTP-loaded Ras.	Guanosine Triphosphate	73-76	RAS guanyl releasing protein 1	Mus musculus	18-25
14532295-6	2003	TPA treatment further elevated this Ras activation in a PKC-independent manner and induced the translocation and down-regulation of RasGRP1.	Tetradecanoylphorbol Acetate	0-3	RAS guanyl releasing protein 1	Mus musculus	132-139
14532295-8	2003	Finally, induction of keratinocyte differentiation by elevation of extracellular calcium suppressed expression of endogenous RasGRP1, whereas overexpression of RasGRP1 inhibited expression of the differentiation markers keratins 1 and 10 induced by high calcium in the medium.	Calcium	81-88	RAS guanyl releasing protein 1	Mus musculus	125-132
14532295-8	2003	Finally, induction of keratinocyte differentiation by elevation of extracellular calcium suppressed expression of endogenous RasGRP1, whereas overexpression of RasGRP1 inhibited expression of the differentiation markers keratins 1 and 10 induced by high calcium in the medium.	Calcium	254-261	RAS guanyl releasing protein 1	Mus musculus	160-167
14532295-9	2003	Taken together, our results demonstrate that RasGRP1 is an additional diacylglycerol/phorbol ester receptor in epidermal keratinocytes and suggest that activation of this novel receptor may contribute to some of the phorbol ester- and Ras-mediated effects in mouse epidermis.	Phorbol Esters	85-98	RAS guanyl releasing protein 1	Mus musculus	45-52
11017103-3	2000	RasGRP, a Ras activator with a DAG-binding C1 domain, is expressed in T cells and thymocytes.	Diglycerides	31-34	RAS guanyl releasing protein 1	Mus musculus	0-6
12626538-6	2003	At early time points, DGK alpha translocation to the membrane correlates with rapid translocation of Ras guanyl nucleotide-releasing protein (RasGRP), a nucleotide exchange activator for Ras that associates to the membrane through a diacylglycerol-binding domain.	Diglycerides	233-247	RAS guanyl releasing protein 1	Mus musculus	101-140
12626538-6	2003	At early time points, DGK alpha translocation to the membrane correlates with rapid translocation of Ras guanyl nucleotide-releasing protein (RasGRP), a nucleotide exchange activator for Ras that associates to the membrane through a diacylglycerol-binding domain.	Diglycerides	233-247	RAS guanyl releasing protein 1	Mus musculus	142-148
33517841-8	2021	We recently published a new RoLoRiG mouse model that allows for pIpC-induced overexpression of RasGRP1 in hematopoietic cells, which can be traced with an ires-EGFP cassette.	Piperacillin	64-68	RAS guanyl releasing protein 1	Mus musculus	95-102
9819387-0	1998	Regulation of RasGRP via a phorbol ester-responsive C1 domain.	Phorbol Esters	27-40	RAS guanyl releasing protein 1	Mus musculus	14-20
9819387-4	1998	The C terminus of mRasGRP contains a pair of EF hands and a C1 domain which is very similar to the phorbol ester- and diacylglycerol-binding C1 domains of protein kinase Cs.	Phorbol Esters	99-112	RAS guanyl releasing protein 1	Mus musculus	18-25
9819387-4	1998	The C terminus of mRasGRP contains a pair of EF hands and a C1 domain which is very similar to the phorbol ester- and diacylglycerol-binding C1 domains of protein kinase Cs.	Diglycerides	118-132	RAS guanyl releasing protein 1	Mus musculus	18-25
9819387-6	1998	In contrast, deletion of the C1 domain or an adjacent cluster of basic amino acids eliminated the transforming activity of mRasGRP.	Amino Acids, Basic	65-82	RAS guanyl releasing protein 1	Mus musculus	123-130
9819387-7	1998	Transformation and MAP kinase activation via mRasGRP were restored if the deleted C1 domain was replaced either by a membrane-localizing prenylation signal or by a diacylglycerol- and phorbol ester-binding C1 domain of protein kinase C. The transforming activity of mRasGRP could be regulated by phorbol ester when serum concentrations were low, and this effect of phorbol ester was dependent on the C1 domain of mRasGRP.	Diglycerides	164-178	RAS guanyl releasing protein 1	Mus musculus	45-52
9819387-7	1998	Transformation and MAP kinase activation via mRasGRP were restored if the deleted C1 domain was replaced either by a membrane-localizing prenylation signal or by a diacylglycerol- and phorbol ester-binding C1 domain of protein kinase C. The transforming activity of mRasGRP could be regulated by phorbol ester when serum concentrations were low, and this effect of phorbol ester was dependent on the C1 domain of mRasGRP.	Phorbol Esters	184-197	RAS guanyl releasing protein 1	Mus musculus	45-52
9819387-7	1998	Transformation and MAP kinase activation via mRasGRP were restored if the deleted C1 domain was replaced either by a membrane-localizing prenylation signal or by a diacylglycerol- and phorbol ester-binding C1 domain of protein kinase C. The transforming activity of mRasGRP could be regulated by phorbol ester when serum concentrations were low, and this effect of phorbol ester was dependent on the C1 domain of mRasGRP.	Phorbol Esters	296-309	RAS guanyl releasing protein 1	Mus musculus	45-52
9819387-7	1998	Transformation and MAP kinase activation via mRasGRP were restored if the deleted C1 domain was replaced either by a membrane-localizing prenylation signal or by a diacylglycerol- and phorbol ester-binding C1 domain of protein kinase C. The transforming activity of mRasGRP could be regulated by phorbol ester when serum concentrations were low, and this effect of phorbol ester was dependent on the C1 domain of mRasGRP.	Phorbol Esters	296-309	RAS guanyl releasing protein 1	Mus musculus	45-52
9819387-9	1998	The C1 domain mediated the translocation of mRasGRP to cell membranes in response to either phorbol ester or serum stimulation.	Phorbol Esters	92-105	RAS guanyl releasing protein 1	Mus musculus	44-51
9819387-10	1998	These results suggest that the primary mechanism of activation of mRasGRP in fibroblasts is through its recruitment to diacylglycerol-enriched membranes.	Diglycerides	119-133	RAS guanyl releasing protein 1	Mus musculus	66-73
9819387-12	1998	In these cells, RasGRP has the potential to serve as a direct link between receptors which stimulate diacylglycerol-generating phospholipase Cs and the activation of Ras.	Diglycerides	101-115	RAS guanyl releasing protein 1	Mus musculus	16-22
9819387-12	1998	In these cells, RasGRP has the potential to serve as a direct link between receptors which stimulate diacylglycerol-generating phospholipase Cs and the activation of Ras.	Cesium	141-143	RAS guanyl releasing protein 1	Mus musculus	16-22
35198649-4	2022	Methods: Wild-type or RasGRP1-deficient mice were treated with lipopolysaccharide intraperitoneally in combination with D-galactosamine to establish a mouse model of sepsis-associated AKI.	Galactosamine	120-135	RAS guanyl releasing protein 1	Mus musculus	22-29
32426479-4	2020	l-DOPA treatment rapidly up-regulated RasGRP1 in the striatum of mouse and macaque model of PD.	Levodopa	0-6	RAS guanyl releasing protein 1	Mus musculus	38-45
33512434-6	2021	Mechanistically, RNA-Seq analysis and quantitative proteomics study identified that Rasgrp1, a Ras guanine nucleotide exchange factor, was greatly downregulated in mouse and human ETP-ALL.	Guanine Nucleotides	99-117	RAS guanyl releasing protein 1	Mus musculus	84-91
33512434-8	2021	Corroborating our cell line data, Rasgrp1 haploinsufficiency induced Rasgrp1 downregulation, increased pERK level, and ETP expansion in NrasQ61R/+ mice.	Ethionamide	119-122	RAS guanyl releasing protein 1	Mus musculus	34-41