PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
2735955-2	1989	N-EthylPP, which lowers cellular heme levels by inhibiting ferrochelatase activity, produced an induction of ALAS activity to 444% of control at 3 hr after its administration.	n-ethylpp	0-9	ferrochelatase	Gallus gallus	59-73
2811858-0	1989	Evidence for the stereoselective inhibition of chick embryo hepatic ferrochelatase by N-alkylated porphyrins.	n-alkylated porphyrins	86-108	ferrochelatase	Gallus gallus	68-82
2735955-2	1989	N-EthylPP, which lowers cellular heme levels by inhibiting ferrochelatase activity, produced an induction of ALAS activity to 444% of control at 3 hr after its administration.	alas	109-113	ferrochelatase	Gallus gallus	59-73
2735955-3	1989	4-Ethyl DDC, which lowers heme levels by destroying the heme moiety of cytochrome P-450 and lowering ferrochelatase activity, caused an induction of ALAS to 565% of control at 12 hr after administration.	3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine	0-11	ferrochelatase	Gallus gallus	101-115
2735955-3	1989	4-Ethyl DDC, which lowers heme levels by destroying the heme moiety of cytochrome P-450 and lowering ferrochelatase activity, caused an induction of ALAS to 565% of control at 12 hr after administration.	alas	149-153	ferrochelatase	Gallus gallus	101-115
2735955-5	1989	This indicates that ferrochelatase inhibition is a more important mechanism of heme lowering than alkylation of cytochrome P-450 heme when both heme-depleting mechanisms are acting in chick embryo liver cells.	Heme	79-83	ferrochelatase	Gallus gallus	20-34
2486279-3	1989	Porphyrinogenic drugs act by lowering a regulatory "free heme pool" by three different mechanisms: (a) by mechanism-based inactivation of cytochrome P-450 resulting in N-alkylprotoporphyrin formation and ferrochelatase inhibition, (b) by mechanism-based inactivation of cytochrome P-450 resulting in continuous heme destruction, (c) by enhanced generation of active oxygen species which interact with an endogenous substrate to form an inhibitor of uroporphyrinogen decarboxylase.	Heme	311-315	ferrochelatase	Gallus gallus	204-218
2486279-3	1989	Porphyrinogenic drugs act by lowering a regulatory "free heme pool" by three different mechanisms: (a) by mechanism-based inactivation of cytochrome P-450 resulting in N-alkylprotoporphyrin formation and ferrochelatase inhibition, (b) by mechanism-based inactivation of cytochrome P-450 resulting in continuous heme destruction, (c) by enhanced generation of active oxygen species which interact with an endogenous substrate to form an inhibitor of uroporphyrinogen decarboxylase.	Oxygen	366-372	ferrochelatase	Gallus gallus	204-218
3664364-1	1987	The ferrochelatase-lowering activity of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) analogues in chick embryo hepatocyte culture has been assumed to be due to the formation of an N-alkylprotoporphyrin IX.	Dicarbethoxydihydrocollidine	40-96	ferrochelatase	Gallus gallus	4-18
2979733-3	1988	Exposure of chick embryo liver cells to DMDQ results in inhibition of their ferrochelatase activity, induction of their 5-aminolevulinic acid synthase activity, and accumulation of protoporphyrin IX.	dmdq	40-44	ferrochelatase	Gallus gallus	76-90
3664364-1	1987	The ferrochelatase-lowering activity of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) analogues in chick embryo hepatocyte culture has been assumed to be due to the formation of an N-alkylprotoporphyrin IX.	Zalcitabine	98-101	ferrochelatase	Gallus gallus	4-18
3664364-1	1987	The ferrochelatase-lowering activity of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) analogues in chick embryo hepatocyte culture has been assumed to be due to the formation of an N-alkylprotoporphyrin IX.	n-alkylprotoporphyrin ix	198-222	ferrochelatase	Gallus gallus	4-18
3113708-2	1987	The ferrochelatase inhibitory activity of a variety of analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) was studied in chick embryo liver cells.	Dicarbethoxydihydrocollidine	68-124	ferrochelatase	Gallus gallus	4-18
2949310-3	1987	A situation analogous to the latent stage of human hepatic porphyria can be produced in chick embryos by injecting an inhibitor of ferrochelatase (the last enzyme in the heme biosynthesis pathway); the simultaneous injection of a porphyrinogenic drug (e.g. barbiturate) results in a strong increase of liver porphyrin levels, as is found in human hepatic porphyrias.	Heme	170-174	ferrochelatase	Gallus gallus	131-145
2949310-3	1987	A situation analogous to the latent stage of human hepatic porphyria can be produced in chick embryos by injecting an inhibitor of ferrochelatase (the last enzyme in the heme biosynthesis pathway); the simultaneous injection of a porphyrinogenic drug (e.g. barbiturate) results in a strong increase of liver porphyrin levels, as is found in human hepatic porphyrias.	barbituric acid	257-268	ferrochelatase	Gallus gallus	131-145
3126696-4	1987	The protoporphyrin:coproporphyrin ratio observed was found to correlate with ferrochelatase-inhibitory activity.	protoporphyrin IX	4-18	ferrochelatase	Gallus gallus	77-91
3113708-3	1987	The ferrochelatase inhibitory activity of the 4-butyl, 4-pentyl, and 4-hexyl analogues was considered to be due to catalytic activation by cytochrome P-450 leading to heme alkylation and formation of the corresponding N-alkylporphyrins.	4-butyl, 4-pentyl, and 4-hexyl	46-76	ferrochelatase	Gallus gallus	4-18
3126696-4	1987	The protoporphyrin:coproporphyrin ratio observed was found to correlate with ferrochelatase-inhibitory activity.	Coproporphyrins	19-33	ferrochelatase	Gallus gallus	77-91
3113708-3	1987	The ferrochelatase inhibitory activity of the 4-butyl, 4-pentyl, and 4-hexyl analogues was considered to be due to catalytic activation by cytochrome P-450 leading to heme alkylation and formation of the corresponding N-alkylporphyrins.	Heme	167-171	ferrochelatase	Gallus gallus	4-18
3113708-3	1987	The ferrochelatase inhibitory activity of the 4-butyl, 4-pentyl, and 4-hexyl analogues was considered to be due to catalytic activation by cytochrome P-450 leading to heme alkylation and formation of the corresponding N-alkylporphyrins.	n-alkylporphyrins	218-235	ferrochelatase	Gallus gallus	4-18
3113708-4	1987	The relative ferrochelatase inhibitory activity of the DDC analogues has implications for a postulated model of the binding of porphyrins in the ferrochelatase active site.	Zalcitabine	55-58	ferrochelatase	Gallus gallus	13-27
3113708-4	1987	The relative ferrochelatase inhibitory activity of the DDC analogues has implications for a postulated model of the binding of porphyrins in the ferrochelatase active site.	Zalcitabine	55-58	ferrochelatase	Gallus gallus	145-159
3113708-5	1987	3-[2-(2,4,6-Trimethylphenyl)thioethyl]-4-methylsydnone (TTMS) was shown to be a potent porphyrinogenic agent and to inhibit ferrochelatase in chick embryo liver cells.	3-(2-(2,4,6-trimethylphenyl)thioethyl)-4-methylsydnone	0-54	ferrochelatase	Gallus gallus	124-138
3113708-5	1987	3-[2-(2,4,6-Trimethylphenyl)thioethyl]-4-methylsydnone (TTMS) was shown to be a potent porphyrinogenic agent and to inhibit ferrochelatase in chick embryo liver cells.	3-(2-(2,4,6-trimethylphenyl)thioethyl)-4-methylsydnone	56-60	ferrochelatase	Gallus gallus	124-138
3113708-7	1987	These results supported the idea that the porphyrinogenicity of TTMS was due to catalytic activation by cytochrome P-450 leading to heme alkylation and formation of N-vinylprotoporphyrin which inhibits ferrochelatase.	N-vinylprotoporphyrin	165-186	ferrochelatase	Gallus gallus	202-216
3113708-9	1987	Thus drug-induced porphyrin biosynthesis in chick embryo liver cell culture appears to be caused by inhibition of either ferrochelatase or uroporphyrinogen decarboxylase.	Porphyrins	18-27	ferrochelatase	Gallus gallus	121-135
6487270-7	1984	Chicken ferrochelatase was inhibited by N-ethylmaleimide and iodoacetamide.	Ethylmaleimide	40-56	ferrochelatase	Gallus gallus	8-22
3730932-0	1986	Comparison of the effects of 3-ethoxycarbonyl-1,4-dihydro-2,4-dimethylpyridine and 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on ferrochelatase activity and heme biosynthesis in chick embryo liver cells in culture.	3-ethoxycarbonyl-1,4-dihydro-2,4-dimethylpyridine	29-78	ferrochelatase	Gallus gallus	143-157
3730932-1	1986	3-Ethoxycarbonyl-1,4-dihydro-2,4-dimethylpyridine (EDP) was shown to lack the ferrochelatase-lowering activity of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) in chick embryo liver cells in culture.	3-ethoxycarbonyl-1,4-dihydro-2,4-dimethylpyridine	0-49	ferrochelatase	Gallus gallus	78-92
3730932-1	1986	3-Ethoxycarbonyl-1,4-dihydro-2,4-dimethylpyridine (EDP) was shown to lack the ferrochelatase-lowering activity of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) in chick embryo liver cells in culture.	3-ethoxycarbonyl-1,4-dihydro-2,4-dimethylpyridine	51-54	ferrochelatase	Gallus gallus	78-92
3730932-4	1986	The inactivity of EDP as a ferrochelatase-lowering agent and its low porphyrinogenic potency was explained, at least in part, by its rapid transformation in aqueous solution to other nondihydropyridine products.	3-ethoxycarbonyl-1,4-dihydro-2,4-dimethylpyridine	18-21	ferrochelatase	Gallus gallus	27-41
3730932-5	1986	The two ethoxycarbonyl substituents of DDC are therefore essential for N-methylprotoporphyrin formation, ferrochelatase-lowering activity, and optimal porphyrin-inducing activity.	Zalcitabine	39-42	ferrochelatase	Gallus gallus	105-119
3949013-2	1986	The accumulation of protoporphyrin IX was consistent with the finding that ferrochelatase activity was inhibited.	protoporphyrin IX	20-37	ferrochelatase	Gallus gallus	75-89
3949013-4	1986	These results support the idea that the porphyrinogenicity of 3-[2-(2,4,6-trimethylphenyl)thioethyl]-4-methylsydnone is due to its catalytic activation by cytochrome P-450 leading to heme alkylation and formation of N-vinylprotoprophyrin IX which inhibits ferrochelatase.	3-(2-(2,4,6-trimethylphenyl)thioethyl)-4-methylsydnone	62-116	ferrochelatase	Gallus gallus	256-270
3949013-4	1986	These results support the idea that the porphyrinogenicity of 3-[2-(2,4,6-trimethylphenyl)thioethyl]-4-methylsydnone is due to its catalytic activation by cytochrome P-450 leading to heme alkylation and formation of N-vinylprotoprophyrin IX which inhibits ferrochelatase.	Heme	183-187	ferrochelatase	Gallus gallus	256-270
3949013-4	1986	These results support the idea that the porphyrinogenicity of 3-[2-(2,4,6-trimethylphenyl)thioethyl]-4-methylsydnone is due to its catalytic activation by cytochrome P-450 leading to heme alkylation and formation of N-vinylprotoprophyrin IX which inhibits ferrochelatase.	n-vinylprotoprophyrin ix	216-240	ferrochelatase	Gallus gallus	256-270
6390167-1	1984	The final step in heme synthesis is catalyzed by the mitochondrial enzyme, ferrochelatase.	Heme	18-22	ferrochelatase	Gallus gallus	75-89
6390167-5	1984	DDC has been found to cause the accumulation of a green pigment, identified as N-methyl protoporphyrin IX (N-MePP), which is a potent inhibitor of ferrochelatase.	Zalcitabine	0-3	ferrochelatase	Gallus gallus	147-161
6390167-5	1984	DDC has been found to cause the accumulation of a green pigment, identified as N-methyl protoporphyrin IX (N-MePP), which is a potent inhibitor of ferrochelatase.	N-methylprotoporphyrin IX	79-105	ferrochelatase	Gallus gallus	147-161
6390167-5	1984	DDC has been found to cause the accumulation of a green pigment, identified as N-methyl protoporphyrin IX (N-MePP), which is a potent inhibitor of ferrochelatase.	N-methylprotoporphyrin IX	107-113	ferrochelatase	Gallus gallus	147-161
3982391-0	1985	Suicidal destruction of cytochrome P-450 and reduction of ferrochelatase activity by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine and its analogues in chick embryo liver cells.	Dicarbethoxydihydrocollidine	85-141	ferrochelatase	Gallus gallus	58-72
3982391-2	1985	A group of DDC analogues was found in which an inability to reduce ferrochelatase activity corresponded with an inability to cause cytochrome P-450 and heme destruction.	Zalcitabine	11-14	ferrochelatase	Gallus gallus	67-81
3982391-3	1985	In a second group of DDC analogues, the ability to reduce ferrochelatase activity corresponded with the ability to cause cytochrome P-450 and heme destruction.	Zalcitabine	21-24	ferrochelatase	Gallus gallus	58-72
3982391-3	1985	In a second group of DDC analogues, the ability to reduce ferrochelatase activity corresponded with the ability to cause cytochrome P-450 and heme destruction.	Heme	142-146	ferrochelatase	Gallus gallus	58-72
6487270-7	1984	Chicken ferrochelatase was inhibited by N-ethylmaleimide and iodoacetamide.	Iodoacetamide	61-74	ferrochelatase	Gallus gallus	8-22
6548141-1	1984	An investigation on the process of heme metabolism with special emphasis on ALA synthetase, heme synthetase and heme oxygenase was studied in cadmium exposed chick embryo to enlighten the mechanism of cadmium embryotoxicity.	Cadmium	142-149	ferrochelatase	Gallus gallus	92-107
6548141-2	1984	Cadmium chloride injection (2.5-10 mumole/kg) to chick embryo increases the activity of ALA synthetase by 5-7 folds, however, it inhibits the activity of heme synthetase significantly.	Cadmium Chloride	0-16	ferrochelatase	Gallus gallus	154-169
7317839-0	1981	Effects of porphyrin-inducing drugs on ferrochelatase activity in isolated mouse hepatocytes.	Porphyrins	11-20	ferrochelatase	Gallus gallus	39-53
6883207-3	1983	Protoporphyrin accumulated in response to 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC), a result consistent with its ability to inhibit ferrochelatase.	protoporphyrin IX	0-14	ferrochelatase	Gallus gallus	154-168
6883207-3	1983	Protoporphyrin accumulated in response to 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC), a result consistent with its ability to inhibit ferrochelatase.	Dicarbethoxydihydrocollidine	42-98	ferrochelatase	Gallus gallus	154-168
6883207-3	1983	Protoporphyrin accumulated in response to 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC), a result consistent with its ability to inhibit ferrochelatase.	Zalcitabine	100-103	ferrochelatase	Gallus gallus	154-168
7082380-3	1982	The activity of ferrochelatase was required for formation of cobalt protoporphyrin since inhibition of ferrochelatase with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (in the presence of cycloheximide) inhibited formation of cobalt protoporphyrin and resulted in accumulation of protoporphyrin.	cobaltiprotoporphyrin	61-82	ferrochelatase	Gallus gallus	16-30
7082380-3	1982	The activity of ferrochelatase was required for formation of cobalt protoporphyrin since inhibition of ferrochelatase with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (in the presence of cycloheximide) inhibited formation of cobalt protoporphyrin and resulted in accumulation of protoporphyrin.	cobaltiprotoporphyrin	61-82	ferrochelatase	Gallus gallus	103-117
7082380-3	1982	The activity of ferrochelatase was required for formation of cobalt protoporphyrin since inhibition of ferrochelatase with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (in the presence of cycloheximide) inhibited formation of cobalt protoporphyrin and resulted in accumulation of protoporphyrin.	3,5-diethoxycarbonyl-1,4-dihydrocollidine	123-164	ferrochelatase	Gallus gallus	16-30
7082380-3	1982	The activity of ferrochelatase was required for formation of cobalt protoporphyrin since inhibition of ferrochelatase with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (in the presence of cycloheximide) inhibited formation of cobalt protoporphyrin and resulted in accumulation of protoporphyrin.	3,5-diethoxycarbonyl-1,4-dihydrocollidine	123-164	ferrochelatase	Gallus gallus	103-117
7082380-3	1982	The activity of ferrochelatase was required for formation of cobalt protoporphyrin since inhibition of ferrochelatase with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (in the presence of cycloheximide) inhibited formation of cobalt protoporphyrin and resulted in accumulation of protoporphyrin.	Cycloheximide	185-198	ferrochelatase	Gallus gallus	16-30
7082380-3	1982	The activity of ferrochelatase was required for formation of cobalt protoporphyrin since inhibition of ferrochelatase with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (in the presence of cycloheximide) inhibited formation of cobalt protoporphyrin and resulted in accumulation of protoporphyrin.	cobaltiprotoporphyrin	223-244	ferrochelatase	Gallus gallus	16-30
7082380-3	1982	The activity of ferrochelatase was required for formation of cobalt protoporphyrin since inhibition of ferrochelatase with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (in the presence of cycloheximide) inhibited formation of cobalt protoporphyrin and resulted in accumulation of protoporphyrin.	cobaltiprotoporphyrin	223-244	ferrochelatase	Gallus gallus	103-117
7082380-3	1982	The activity of ferrochelatase was required for formation of cobalt protoporphyrin since inhibition of ferrochelatase with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (in the presence of cycloheximide) inhibited formation of cobalt protoporphyrin and resulted in accumulation of protoporphyrin.	protoporphyrin IX	68-82	ferrochelatase	Gallus gallus	16-30
7082380-3	1982	The activity of ferrochelatase was required for formation of cobalt protoporphyrin since inhibition of ferrochelatase with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (in the presence of cycloheximide) inhibited formation of cobalt protoporphyrin and resulted in accumulation of protoporphyrin.	protoporphyrin IX	68-82	ferrochelatase	Gallus gallus	103-117
6896292-0	1982	Inhibition of ferrochelatase by N-methylprotoporphyrin IX is not accompanied by delta-aminolevulinic acid synthetase induction in chick embryo liver cell culture.	N-methylprotoporphyrin IX	32-57	ferrochelatase	Gallus gallus	14-28
6896292-1	1982	N-Methylprotoporphyrin has been shown to markedly inhibit ferrochelatase activity in chick embryo liver cell culture without inducing delta-aminolevulinic acid (ALA) synthetase activity.	N-methylprotoporphyrin IX	0-22	ferrochelatase	Gallus gallus	58-72
6896292-2	1982	This result supports the idea that the effects of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) on ALA synthetase activity and ferrochelatase activity are dissociated and that inhibition of ferrochelatase alone is not sufficient to cause induction of ALA synthetase.	Zalcitabine	108-111	ferrochelatase	Gallus gallus	207-221
7266472-0	1981	Comparison of the effects of griseofulvin and 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on ferrochelatase activity in chick embryo liver.	Dicarbethoxydihydrocollidine	46-102	ferrochelatase	Gallus gallus	106-120
8609896-0	1996	Isolation of N-vinylprotoporphyrin IX after hepatic cytochrome P450 inactivation by 3-[(arylthio)ethyl]sydnone in chick embryos pretreated with phenobarbital, glutethimide, dexamethasone, and beta-naphthoflavone: differential inhibition of ferrochelatase by N-vinylprotoporphyrin regioisomers.	21-Vinylprotoporphyrin	13-37	ferrochelatase	Gallus gallus	240-254
571439-0	1979	Maintenance of microsomal hemoprotein concentrations following inhibition of ferrochelatase activity by 3,5-diethoxycarbonyl-1,4-dihydrocollidine in chick embryo liver.	3,5-diethoxycarbonyl-1,4-dihydrocollidine	104-145	ferrochelatase	Gallus gallus	77-91
24612318-4	2014	Coproporphyrinogen III oxidase (CPOX) and ferrochelatase (FECH) represent rate-limiting enzymes for the heme-biosynthetic pathway.	Heme	104-108	ferrochelatase	Gallus gallus	42-56
24612318-4	2014	Coproporphyrinogen III oxidase (CPOX) and ferrochelatase (FECH) represent rate-limiting enzymes for the heme-biosynthetic pathway.	Heme	104-108	ferrochelatase	Gallus gallus	58-62
24612318-11	2014	In contrast, high expression of FECH likely converted more protoporphyrinogen into heme, reduced protoporphyrinogen levels within the eggshell and generated a light color.	protoporphyrinogen	59-77	ferrochelatase	Gallus gallus	32-36
24612318-11	2014	In contrast, high expression of FECH likely converted more protoporphyrinogen into heme, reduced protoporphyrinogen levels within the eggshell and generated a light color.	Heme	83-87	ferrochelatase	Gallus gallus	32-36
24612318-11	2014	In contrast, high expression of FECH likely converted more protoporphyrinogen into heme, reduced protoporphyrinogen levels within the eggshell and generated a light color.	protoporphyrinogen	97-115	ferrochelatase	Gallus gallus	32-36
10725301-0	2000	N-Methylprotoporphyrin is a more potent inhibitor of recombinant human than of recombinant chicken ferrochelatase.	N-methylprotoporphyrin IX	0-22	ferrochelatase	Gallus gallus	99-113
10725301-1	2000	The potency of N-methylprotoporphyrin IX (N-methylPP) as a ferrochelatase (FC) inhibitor has been previously studied using crude chick embryo liver FC preparations.	N-methylprotoporphyrin IX	15-40	ferrochelatase	Gallus gallus	59-73
10725301-1	2000	The potency of N-methylprotoporphyrin IX (N-methylPP) as a ferrochelatase (FC) inhibitor has been previously studied using crude chick embryo liver FC preparations.	N-methylprotoporphyrin IX	15-40	ferrochelatase	Gallus gallus	75-77
10725301-1	2000	The potency of N-methylprotoporphyrin IX (N-methylPP) as a ferrochelatase (FC) inhibitor has been previously studied using crude chick embryo liver FC preparations.	N-methylprotoporphyrin IX	15-40	ferrochelatase	Gallus gallus	148-150
10725301-3	2000	The first objective of this study was to compare the potency of N-methylPP as an inhibitor of purified chicken FC and crude chick embryo liver FC.	N-methylprotoporphyrin IX	64-74	ferrochelatase	Gallus gallus	111-113
10725301-3	2000	The first objective of this study was to compare the potency of N-methylPP as an inhibitor of purified chicken FC and crude chick embryo liver FC.	N-methylprotoporphyrin IX	64-74	ferrochelatase	Gallus gallus	143-145
10725301-4	2000	The EC(50) values of N-methylPP previously observed in crude chick embryo liver FC was 2.9 x 10(-3) nmol/mg protein, and with purified recombinant chicken FC was 2.07 x 10(-3) nmol/mg protein.	N-methylprotoporphyrin IX	21-31	ferrochelatase	Gallus gallus	80-82
10725301-6	2000	The second objective of this study was to compare the potency of N-methylPP between purified human and chicken FC.	N-methylprotoporphyrin IX	65-75	ferrochelatase	Gallus gallus	111-113
10725301-7	2000	The EC(50) value of N-methylPP observed in the purified human FC preparation was 1.7 x 10(-6) nmol/mg protein (chicken FC 2.07 x 10(-3) nmol/mg protein).	N-methylprotoporphyrin IX	20-30	ferrochelatase	Gallus gallus	62-64
10725301-8	2000	Thus, the potency of N-methylPP was much higher with purified human FC than with purified chicken FC.	N-methylprotoporphyrin IX	21-31	ferrochelatase	Gallus gallus	68-70
7300820-0	1981	Ferrochelatase-inhibitory and porphyrin-inducing properties of 3,5-diethoxycarbonyl-1, 4-dihydro-2,4,6-trimethylpyridine and its analogues in chick embryo liver cells.	Dicarbethoxydihydrocollidine	63-120	ferrochelatase	Gallus gallus	0-14
533555-1	1979	Potentiation of the porphyrin-inducing effects of SKF 525-A in the chick embryo liver by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine, an antihibitor of ferrochelatase.	Porphyrins	20-29	ferrochelatase	Gallus gallus	165-179
533555-1	1979	Potentiation of the porphyrin-inducing effects of SKF 525-A in the chick embryo liver by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine, an antihibitor of ferrochelatase.	Proadifen	50-59	ferrochelatase	Gallus gallus	165-179
533555-1	1979	Potentiation of the porphyrin-inducing effects of SKF 525-A in the chick embryo liver by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine, an antihibitor of ferrochelatase.	Dicarbethoxydihydrocollidine	89-145	ferrochelatase	Gallus gallus	165-179
12387936-0	2002	Porphyrinogenic xenobiotic-induced N-alkylprotoporphyrin IX formation: a bioassay utilizing chick embryo hepatic ferrochelatase.	n-alkylprotoporphyrin ix	35-59	ferrochelatase	Gallus gallus	113-127
12387936-1	2002	INTRODUCTION: The porphyrinogenicity of some xenobiotics results from mechanism-based inactivation of selected cytochrome P450 (CYP) enzymes accompanied by conversion of prosthetic heme groups to N-alkylprotoporphyrins (N-alkylPPs), some of which inhibit ferrochelatase (FC).	Heme	181-185	ferrochelatase	Gallus gallus	255-269
12387936-1	2002	INTRODUCTION: The porphyrinogenicity of some xenobiotics results from mechanism-based inactivation of selected cytochrome P450 (CYP) enzymes accompanied by conversion of prosthetic heme groups to N-alkylprotoporphyrins (N-alkylPPs), some of which inhibit ferrochelatase (FC).	Heme	181-185	ferrochelatase	Gallus gallus	271-273
12387936-1	2002	INTRODUCTION: The porphyrinogenicity of some xenobiotics results from mechanism-based inactivation of selected cytochrome P450 (CYP) enzymes accompanied by conversion of prosthetic heme groups to N-alkylprotoporphyrins (N-alkylPPs), some of which inhibit ferrochelatase (FC).	n-alkylprotoporphyrins	196-218	ferrochelatase	Gallus gallus	255-269
12387936-1	2002	INTRODUCTION: The porphyrinogenicity of some xenobiotics results from mechanism-based inactivation of selected cytochrome P450 (CYP) enzymes accompanied by conversion of prosthetic heme groups to N-alkylprotoporphyrins (N-alkylPPs), some of which inhibit ferrochelatase (FC).	n-alkylprotoporphyrins	196-218	ferrochelatase	Gallus gallus	271-273
12387936-5	2002	The FC activity of this fraction was determined by means of the pyridine hemochromogen method.	pyridine	64-72	ferrochelatase	Gallus gallus	4-6
12387936-11	2002	DISCUSSION: In future studies investigating N-alkylPP formation following interaction of xenobiotics with CYP enzymes, we recommend using a combination of a fluorescence technique and the chick embryo hepatic mitochondrial FC assay.	n-alkylpp	44-53	ferrochelatase	Gallus gallus	223-225
12387936-12	2002	This would provide information both on the formation of N-alkylPPs and distinguish between those N-alkylPPs that produced porphyrin accumulation via FC inhibition and those that do not.	Porphyrins	122-131	ferrochelatase	Gallus gallus	149-151
9808757-1	1998	Ferrochelatase (EC 4.99.1.1) catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme IX.	Iron	56-68	ferrochelatase	Gallus gallus	0-14
9808757-1	1998	Ferrochelatase (EC 4.99.1.1) catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme IX.	protoporphyrin IX	74-91	ferrochelatase	Gallus gallus	0-14
9808757-1	1998	Ferrochelatase (EC 4.99.1.1) catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme IX.	Heme	100-112	ferrochelatase	Gallus gallus	0-14
8609896-0	1996	Isolation of N-vinylprotoporphyrin IX after hepatic cytochrome P450 inactivation by 3-[(arylthio)ethyl]sydnone in chick embryos pretreated with phenobarbital, glutethimide, dexamethasone, and beta-naphthoflavone: differential inhibition of ferrochelatase by N-vinylprotoporphyrin regioisomers.	N-vinylprotoporphyrin	13-34	ferrochelatase	Gallus gallus	240-254
8609896-2	1996	Loss of iron from the alkylated heme results in formation of an N-alkylporphyrin, which is a potent inhibitor of ferrochelatase.	Iron	8-12	ferrochelatase	Gallus gallus	113-127
8609896-2	1996	Loss of iron from the alkylated heme results in formation of an N-alkylporphyrin, which is a potent inhibitor of ferrochelatase.	Heme	32-36	ferrochelatase	Gallus gallus	113-127
8609896-2	1996	Loss of iron from the alkylated heme results in formation of an N-alkylporphyrin, which is a potent inhibitor of ferrochelatase.	n-alkylporphyrin	64-80	ferrochelatase	Gallus gallus	113-127
8609896-7	1996	Previously, the finding that the NB regioisomer of N-ethylprotoporphyrin IX had one fifth the potency of the ring A-substituted (NA) regioisomer as a ferrochelatase inhibitor led to a proposal that an A-C ring tilt was important in N-alkylprotoporphyrins for ferrochelatase inhibition.	N-ethylprotoporphyrin IX	51-75	ferrochelatase	Gallus gallus	150-164
8609896-7	1996	Previously, the finding that the NB regioisomer of N-ethylprotoporphyrin IX had one fifth the potency of the ring A-substituted (NA) regioisomer as a ferrochelatase inhibitor led to a proposal that an A-C ring tilt was important in N-alkylprotoporphyrins for ferrochelatase inhibition.	N-ethylprotoporphyrin IX	51-75	ferrochelatase	Gallus gallus	259-273
1859461-2	1991	N-Ethylprotoporphyrin IX (N-EtPP), which is believed to lower heme levels by inhibition of ferrochelatase (FC), had little effect on steady-state ALAS mRNA levels.	N-ethylprotoporphyrin IX	0-24	ferrochelatase	Gallus gallus	91-105
1473038-5	1992	The ability of 4-nonyl DDC and 4-dodecyl DDC to lower ferrochelatase activity was compared with that of 4-ethyl DDC and 4-hexyl DDC in cultured chick embryo hepatocytes.	4-nonyl-3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethylpyridine	15-26	ferrochelatase	Gallus gallus	54-68
1473038-5	1992	The ability of 4-nonyl DDC and 4-dodecyl DDC to lower ferrochelatase activity was compared with that of 4-ethyl DDC and 4-hexyl DDC in cultured chick embryo hepatocytes.	4-dodecyl-3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethylpyridine	31-44	ferrochelatase	Gallus gallus	54-68
1473038-6	1992	As the length of the 4-alkyl group was increased, the ferrochelatase-lowering efficacy and potency of the DDC analogue decreased.	Zalcitabine	106-109	ferrochelatase	Gallus gallus	54-68
1513328-0	1992	Evidence for the stereoselective inhibition of chick embryo hepatic ferrochelatase by N-alkylated porphyrins.	n-alkylated porphyrins	86-108	ferrochelatase	Gallus gallus	68-82
8963944-4	1996	The major N-alkyl PP, N-griseofulvin PP, which is devoid of ferrochelatase-inhibitory activity, was shown to be the precursor of N-methyl PP, which is a potent ferrochelatase inhibitor.	n-alkyl pp	10-20	ferrochelatase	Gallus gallus	160-174
8963944-4	1996	The major N-alkyl PP, N-griseofulvin PP, which is devoid of ferrochelatase-inhibitory activity, was shown to be the precursor of N-methyl PP, which is a potent ferrochelatase inhibitor.	n-griseofulvin pp	22-39	ferrochelatase	Gallus gallus	60-74
8963944-4	1996	The major N-alkyl PP, N-griseofulvin PP, which is devoid of ferrochelatase-inhibitory activity, was shown to be the precursor of N-methyl PP, which is a potent ferrochelatase inhibitor.	n-griseofulvin pp	22-39	ferrochelatase	Gallus gallus	160-174
8963944-4	1996	The major N-alkyl PP, N-griseofulvin PP, which is devoid of ferrochelatase-inhibitory activity, was shown to be the precursor of N-methyl PP, which is a potent ferrochelatase inhibitor.	N-methylprotoporphyrin IX	129-140	ferrochelatase	Gallus gallus	160-174
1473038-0	1992	Inactivation of cytochrome P450 and inhibition of ferrochelatase by analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine with 4-nonyl and 4-dodecyl substituents.	Dicarbethoxydihydrocollidine	81-137	ferrochelatase	Gallus gallus	50-64
1473038-0	1992	Inactivation of cytochrome P450 and inhibition of ferrochelatase by analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine with 4-nonyl and 4-dodecyl substituents.	4-nonyl	143-150	ferrochelatase	Gallus gallus	50-64
1473038-0	1992	Inactivation of cytochrome P450 and inhibition of ferrochelatase by analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine with 4-nonyl and 4-dodecyl substituents.	-dodecyl substituents	156-177	ferrochelatase	Gallus gallus	50-64
1859461-2	1991	N-Ethylprotoporphyrin IX (N-EtPP), which is believed to lower heme levels by inhibition of ferrochelatase (FC), had little effect on steady-state ALAS mRNA levels.	N-ethylprotoporphyrin IX	26-32	ferrochelatase	Gallus gallus	91-105
1859461-9	1991	The elevation of ALAS mRNA by these porphyrinogenic agents is probably due to their lowering of cellular heme levels by a combination of ferrochelatase inhibition and repetitive destruction of the heme moiety of cytochrome P450.	alas	17-21	ferrochelatase	Gallus gallus	137-151
1859461-9	1991	The elevation of ALAS mRNA by these porphyrinogenic agents is probably due to their lowering of cellular heme levels by a combination of ferrochelatase inhibition and repetitive destruction of the heme moiety of cytochrome P450.	Heme	105-109	ferrochelatase	Gallus gallus	137-151