PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 7618340-4 1995 Hepatic microsomes of sexually mature fish contained NADPH-dependent FMO as evidenced by the conversion of N,N-dimethylaniline (DMA) to DMA-N-oxide, and immunorecognition of single bands (approximate apparent molecular weight of 55 kDa) by antibodies to mammalian FMO 1 and FMO 2. NADP 53-58 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 264-269 7720101-12 1995 FMO1 and FMO3, expressed in either system, displayed product stereoselectivity in their catalysis of the N-oxidation of the pro-chiral tertiary amines, N-ethyl-N-methylaniline (EMA) and pargyline. Amines 144-150 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-4 7720101-12 1995 FMO1 and FMO3, expressed in either system, displayed product stereoselectivity in their catalysis of the N-oxidation of the pro-chiral tertiary amines, N-ethyl-N-methylaniline (EMA) and pargyline. N-ethyl-N-methylaniline 152-175 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-4 7720101-12 1995 FMO1 and FMO3, expressed in either system, displayed product stereoselectivity in their catalysis of the N-oxidation of the pro-chiral tertiary amines, N-ethyl-N-methylaniline (EMA) and pargyline. N-ethyl-N-methylaniline 177-180 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-4 7720101-12 1995 FMO1 and FMO3, expressed in either system, displayed product stereoselectivity in their catalysis of the N-oxidation of the pro-chiral tertiary amines, N-ethyl-N-methylaniline (EMA) and pargyline. Pargyline 186-195 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-4 7720101-14 1995 But in the case of pargyline, the enzymes displayed opposite stereoselectivity, FMO1 producing solely the (+)-enantiomer and FMO3 predominantly the (-)-enantiomer of the N-oxide. Pargyline 19-28 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 80-84 7720101-14 1995 But in the case of pargyline, the enzymes displayed opposite stereoselectivity, FMO1 producing solely the (+)-enantiomer and FMO3 predominantly the (-)-enantiomer of the N-oxide. n-oxide 170-177 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 80-84 33746664-3 2021 It is formed by the process of oxidation of trimethylamine (TMA) by the hepatic flavin monooxygenases (FMO1 and FMO3). trimethylamine 44-58 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 103-107 34509493-0 2021 Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate. hydroperoxyflavin 60-77 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 6-39 34509493-5 2021 In this work we demonstrate spectrophotometrically the formation of a highly stable C4a-hydroperoxyflavin intermediate of hFMO1 upon reduction by NADPH and in the presence of O2. NADP 146-151 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 122-127 34509493-5 2021 In this work we demonstrate spectrophotometrically the formation of a highly stable C4a-hydroperoxyflavin intermediate of hFMO1 upon reduction by NADPH and in the presence of O2. Oxygen 175-177 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 122-127 34509493-7 2021 In addition, the uncoupling reactions of hFMO1 show that this enzyme is <1% uncoupled in the presence of substrate, forming small amounts of H2O2 with no observable superoxide as confirmed by EPR spin trapping experiments. Hydrogen Peroxide 141-145 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 41-46 35065293-2 2022 The conversion of TMA to TMAO is mainly catalyzed by flavin-containing monooxygenases 3 (FMO3) and FMO1. trimethylamine 18-21 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 99-103 35065293-10 2022 In addition, the contents of FFA, TG, FMO1 expression, and TMAO were significantly increased after OA + palmitate and TMA stimulation. oa + palmitate 99-113 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 38-42 35065293-10 2022 In addition, the contents of FFA, TG, FMO1 expression, and TMAO were significantly increased after OA + palmitate and TMA stimulation. trimethylamine 118-121 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 38-42 35065293-13 2022 In Conclusion, high fat and TMA could induce the expression of FMO1 and its metabolite TMAO. trimethylamine 28-31 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 63-67 35065293-13 2022 In Conclusion, high fat and TMA could induce the expression of FMO1 and its metabolite TMAO. trimethyloxamine 87-91 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 63-67 33759784-6 2021 It displayed typical FMO activities as demonstrated by oxygenating benzydamine, tamoxifen, and thioanisole, drug-related compounds known to be also accepted by human FMO1, and both NADH and NADPH cofactors could act as electron donors, a feature only described for the FMO1 paralogs. Benzydamine 67-78 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 166-170 33533968-3 2021 TMAO production results from the fermentation by the gut microbiota of dietary nutrients such as choline and carnitine, which are transformed to trimethylamine (TMA) and converted into TMAO in the liver by flavin-containing monooxygenase 1 and 3 (FMO1 and FMO3). trimethyloxamine 0-4 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 206-245 33533968-3 2021 TMAO production results from the fermentation by the gut microbiota of dietary nutrients such as choline and carnitine, which are transformed to trimethylamine (TMA) and converted into TMAO in the liver by flavin-containing monooxygenase 1 and 3 (FMO1 and FMO3). trimethyloxamine 0-4 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 247-251 33533968-3 2021 TMAO production results from the fermentation by the gut microbiota of dietary nutrients such as choline and carnitine, which are transformed to trimethylamine (TMA) and converted into TMAO in the liver by flavin-containing monooxygenase 1 and 3 (FMO1 and FMO3). Choline 97-104 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 206-245 33533968-3 2021 TMAO production results from the fermentation by the gut microbiota of dietary nutrients such as choline and carnitine, which are transformed to trimethylamine (TMA) and converted into TMAO in the liver by flavin-containing monooxygenase 1 and 3 (FMO1 and FMO3). Choline 97-104 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 247-251 33533968-3 2021 TMAO production results from the fermentation by the gut microbiota of dietary nutrients such as choline and carnitine, which are transformed to trimethylamine (TMA) and converted into TMAO in the liver by flavin-containing monooxygenase 1 and 3 (FMO1 and FMO3). Carnitine 109-118 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 206-245 33533968-3 2021 TMAO production results from the fermentation by the gut microbiota of dietary nutrients such as choline and carnitine, which are transformed to trimethylamine (TMA) and converted into TMAO in the liver by flavin-containing monooxygenase 1 and 3 (FMO1 and FMO3). Carnitine 109-118 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 247-251 33533968-3 2021 TMAO production results from the fermentation by the gut microbiota of dietary nutrients such as choline and carnitine, which are transformed to trimethylamine (TMA) and converted into TMAO in the liver by flavin-containing monooxygenase 1 and 3 (FMO1 and FMO3). trimethylamine 145-159 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 206-245 33533968-3 2021 TMAO production results from the fermentation by the gut microbiota of dietary nutrients such as choline and carnitine, which are transformed to trimethylamine (TMA) and converted into TMAO in the liver by flavin-containing monooxygenase 1 and 3 (FMO1 and FMO3). trimethyloxamine 185-189 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 206-245 33533968-3 2021 TMAO production results from the fermentation by the gut microbiota of dietary nutrients such as choline and carnitine, which are transformed to trimethylamine (TMA) and converted into TMAO in the liver by flavin-containing monooxygenase 1 and 3 (FMO1 and FMO3). trimethyloxamine 185-189 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 247-251 33759784-6 2021 It displayed typical FMO activities as demonstrated by oxygenating benzydamine, tamoxifen, and thioanisole, drug-related compounds known to be also accepted by human FMO1, and both NADH and NADPH cofactors could act as electron donors, a feature only described for the FMO1 paralogs. Benzydamine 67-78 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 269-273 33759784-6 2021 It displayed typical FMO activities as demonstrated by oxygenating benzydamine, tamoxifen, and thioanisole, drug-related compounds known to be also accepted by human FMO1, and both NADH and NADPH cofactors could act as electron donors, a feature only described for the FMO1 paralogs. Tamoxifen 80-89 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 166-170 33759784-6 2021 It displayed typical FMO activities as demonstrated by oxygenating benzydamine, tamoxifen, and thioanisole, drug-related compounds known to be also accepted by human FMO1, and both NADH and NADPH cofactors could act as electron donors, a feature only described for the FMO1 paralogs. methylphenylsulfide 95-106 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 166-170 33759784-6 2021 It displayed typical FMO activities as demonstrated by oxygenating benzydamine, tamoxifen, and thioanisole, drug-related compounds known to be also accepted by human FMO1, and both NADH and NADPH cofactors could act as electron donors, a feature only described for the FMO1 paralogs. methylphenylsulfide 95-106 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 269-273 33759784-6 2021 It displayed typical FMO activities as demonstrated by oxygenating benzydamine, tamoxifen, and thioanisole, drug-related compounds known to be also accepted by human FMO1, and both NADH and NADPH cofactors could act as electron donors, a feature only described for the FMO1 paralogs. NAD 181-185 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 269-273 28290528-9 2018 We demonstrate for the first time nicotine N-oxidation in human brain, mediated by FMO3 and FMO1, and show that nicotine-N-oxide modulates human alpha4beta2 nicotinic receptor activity in vitro. Nicotine 34-42 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 92-96 32156684-0 2020 Flavin-Containing Monooxygenase 1 (FMO1) Catalyzes the Production of Taurine from Hypotaurine. Taurine 69-76 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-33 32156684-0 2020 Flavin-Containing Monooxygenase 1 (FMO1) Catalyzes the Production of Taurine from Hypotaurine. Taurine 69-76 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 35-39 32156684-0 2020 Flavin-Containing Monooxygenase 1 (FMO1) Catalyzes the Production of Taurine from Hypotaurine. hypotaurine 82-93 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-33 32156684-0 2020 Flavin-Containing Monooxygenase 1 (FMO1) Catalyzes the Production of Taurine from Hypotaurine. hypotaurine 82-93 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 35-39 32156684-6 2020 Here we show, both in vivo and in vitro, that the enzyme that oxygenates hypotaurine to produce taurine is flavin-containing monooxygenase 1 (FMO1). hypotaurine 73-84 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 107-140 32156684-6 2020 Here we show, both in vivo and in vitro, that the enzyme that oxygenates hypotaurine to produce taurine is flavin-containing monooxygenase 1 (FMO1). hypotaurine 73-84 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 142-146 32156684-6 2020 Here we show, both in vivo and in vitro, that the enzyme that oxygenates hypotaurine to produce taurine is flavin-containing monooxygenase 1 (FMO1). Taurine 77-84 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 107-140 32156684-6 2020 Here we show, both in vivo and in vitro, that the enzyme that oxygenates hypotaurine to produce taurine is flavin-containing monooxygenase 1 (FMO1). Taurine 77-84 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 142-146 32156684-8 2020 In vitro assays confirmed that human FMO1 catalyzes the conversion of hypotaurine to taurine utilizing either NADPH or NADH as co-factor. hypotaurine 70-81 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 37-41 32156684-8 2020 In vitro assays confirmed that human FMO1 catalyzes the conversion of hypotaurine to taurine utilizing either NADPH or NADH as co-factor. Taurine 74-81 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 37-41 32156684-8 2020 In vitro assays confirmed that human FMO1 catalyzes the conversion of hypotaurine to taurine utilizing either NADPH or NADH as co-factor. NADP 110-115 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 37-41 32156684-8 2020 In vitro assays confirmed that human FMO1 catalyzes the conversion of hypotaurine to taurine utilizing either NADPH or NADH as co-factor. NAD 119-123 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 37-41 32156684-10 2020 The identification that the endogenous molecule hypotaurine is a substrate for the FMO1-catalyzed production of taurine resolves a long-standing mystery. hypotaurine 48-59 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 83-87 32156684-10 2020 The identification that the endogenous molecule hypotaurine is a substrate for the FMO1-catalyzed production of taurine resolves a long-standing mystery. Taurine 52-59 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 83-87 32156684-11 2020 This finding should help establish the role FMO1 plays in a range of biological processes in which taurine or its deficiency is implicated, including conjugation of bile acids, neurotransmitter, anti-oxidant and anti-inflammatory functions, and the pathogenesis of obesity and skeletal muscle disorders. Taurine 99-106 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 44-48 32156684-11 2020 This finding should help establish the role FMO1 plays in a range of biological processes in which taurine or its deficiency is implicated, including conjugation of bile acids, neurotransmitter, anti-oxidant and anti-inflammatory functions, and the pathogenesis of obesity and skeletal muscle disorders. Bile Acids and Salts 165-175 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 44-48 32156684-13 2020 Here we show, both in vivo and in vitro, that flavin-containing monooxygenase 1 (FMO1) catalyzes the oxygenation of hypotaurine to produce taurine. hypotaurine 116-127 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 46-79 32156684-13 2020 Here we show, both in vivo and in vitro, that flavin-containing monooxygenase 1 (FMO1) catalyzes the oxygenation of hypotaurine to produce taurine. hypotaurine 116-127 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 81-85 32156684-13 2020 Here we show, both in vivo and in vitro, that flavin-containing monooxygenase 1 (FMO1) catalyzes the oxygenation of hypotaurine to produce taurine. Taurine 120-127 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 46-79 32156684-13 2020 Here we show, both in vivo and in vitro, that flavin-containing monooxygenase 1 (FMO1) catalyzes the oxygenation of hypotaurine to produce taurine. Taurine 120-127 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 81-85 31295928-5 2019 Recombinant CYP3A4 was most efficient to form N-desmethylvandetanib, while FMO1/FMO3 generated N-oxide. n-oxide 95-102 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 75-79 29642641-9 2018 Moreover, two very recent papers, added in proof, demonstrated the role of FMO1 (FLAVIN-DEPENDENT-MONOOXYGENASE1) in conversion of Pip to N-hydroxypipecolic acid (NHP). pipecolic acid 131-134 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 75-79 29642641-9 2018 Moreover, two very recent papers, added in proof, demonstrated the role of FMO1 (FLAVIN-DEPENDENT-MONOOXYGENASE1) in conversion of Pip to N-hydroxypipecolic acid (NHP). pipecolic acid 131-134 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 81-112 29642641-9 2018 Moreover, two very recent papers, added in proof, demonstrated the role of FMO1 (FLAVIN-DEPENDENT-MONOOXYGENASE1) in conversion of Pip to N-hydroxypipecolic acid (NHP). N-hydroxypipecolic acid 138-161 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 75-79 30018103-6 2018 ADT S-oxidation is catalyzed by FMO 1 and 3, and to a minor extent by CYP enzymes such as CYP3A4. adt 0-3 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 32-43 29642641-9 2018 Moreover, two very recent papers, added in proof, demonstrated the role of FMO1 (FLAVIN-DEPENDENT-MONOOXYGENASE1) in conversion of Pip to N-hydroxypipecolic acid (NHP). N-hydroxypipecolic acid 138-161 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 81-112 29642641-9 2018 Moreover, two very recent papers, added in proof, demonstrated the role of FMO1 (FLAVIN-DEPENDENT-MONOOXYGENASE1) in conversion of Pip to N-hydroxypipecolic acid (NHP). nhp 163-166 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 75-79 29642641-9 2018 Moreover, two very recent papers, added in proof, demonstrated the role of FMO1 (FLAVIN-DEPENDENT-MONOOXYGENASE1) in conversion of Pip to N-hydroxypipecolic acid (NHP). nhp 163-166 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 81-112 25760531-6 2015 High benzydamine N-oxygenation activities of recombinant human FMO1 and FMO3 and human kidney microsomes were observed at pH 8.4, whereas N-demethylation by cytochrome P450 2D6 was faster at pH 7.4. benzydamine n 5-18 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 63-67 27943222-5 2017 Cediranib is metabolized via flavin-containing monooxygenase 1 and 3 (FMO1, FMO3) and uridine 5"-diphospho-glucuronosyltransferase (UGT) 1A4. cediranib 0-9 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 29-68 27943222-5 2017 Cediranib is metabolized via flavin-containing monooxygenase 1 and 3 (FMO1, FMO3) and uridine 5"-diphospho-glucuronosyltransferase (UGT) 1A4. cediranib 0-9 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 70-74 28413702-4 2017 Both FMO1 and FMO3 were potentially susceptible genes for nicotine metabolism process. Nicotine 58-66 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 5-9 25451157-7 2015 GSK5182 N-demethylation and hydroxylation is mainly mediated by CYP3A4, whereas FMO1 and FMO3 contribute to the formation of GSK5182 N-oxide from GSK5182. gsk5182 n-oxide 125-140 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 80-84 25760531-6 2015 High benzydamine N-oxygenation activities of recombinant human FMO1 and FMO3 and human kidney microsomes were observed at pH 8.4, whereas N-demethylation by cytochrome P450 2D6 was faster at pH 7.4. Nitrogen 17-18 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 63-67 25760531-7 2015 These results suggest that benzydamine N-oxygenation and N-demethylation are mediated by FMO1/3 and P450s, respectively, and that the contribution of FMO to metabolic eliminations of new drug candidates might be underestimated under certain experimental conditions suitable for P450 enzymes. Benzydamine 27-38 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 89-93 24440618-6 2014 We found that in rotenone model of Parkinsonism, the expression/protein level of parkin and FMO1 were decreased accompanied by the activation of caspase 3. Rotenone 17-25 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 92-96 24727368-10 2014 However, hFMO1, the major isoform expressed in infant and neonatal liver and adult kidney and intestine, readily S-oxygenated thiones under test, with Kms ranging from 7 to 160 muM and turnover numbers of 30-40 min(-1). Thiones 126-133 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 9-14 24727368-12 2014 The activities of the mouse and human FMO1 and FMO3 orthologs were in good agreement with the exception of some thiones for which activity was much greater with hFMO1 than mFMO1. Thiones 112-119 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 38-42 24727368-12 2014 The activities of the mouse and human FMO1 and FMO3 orthologs were in good agreement with the exception of some thiones for which activity was much greater with hFMO1 than mFMO1. Thiones 112-119 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 161-166 24561181-2 2014 Human FMOs 1, 2 and 3, expressed in Sf9 insect microsomes, released 30-50% of O2 consumed as H2O2 upon addition of NADPH. Oxygen 78-80 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 6-21 24561181-2 2014 Human FMOs 1, 2 and 3, expressed in Sf9 insect microsomes, released 30-50% of O2 consumed as H2O2 upon addition of NADPH. Hydrogen Peroxide 93-97 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 6-21 24561181-2 2014 Human FMOs 1, 2 and 3, expressed in Sf9 insect microsomes, released 30-50% of O2 consumed as H2O2 upon addition of NADPH. NADP 115-120 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 6-21 23147717-3 2013 We investigated the influence of FMO1 and 3 polymorphisms on the steady state serum concentrations of OLA and its N-oxide metabolite in 379 patients. Olanzapine 102-105 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 33-43 23147717-0 2013 Influence of FMO1 and 3 polymorphisms on serum olanzapine and its N-oxide metabolite in psychiatric patients. Olanzapine 47-57 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 13-23 23147717-4 2013 The upstream FMO1*6 was associated with increased dose-adjusted serum OLA concentrations (C/Ds; P=0.008), an effect further enhanced by FMO1rs7877C>T in smokers. Olanzapine 70-73 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 13-17 23147717-0 2013 Influence of FMO1 and 3 polymorphisms on serum olanzapine and its N-oxide metabolite in psychiatric patients. n-oxide 66-73 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 13-23 23147717-4 2013 The upstream FMO1*6 was associated with increased dose-adjusted serum OLA concentrations (C/Ds; P=0.008), an effect further enhanced by FMO1rs7877C>T in smokers. Olanzapine 70-73 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 136-140 23640382-5 2013 FMO1 catalyzed the formation of slightly less d-DMANO than l-DMANO, and the Clint ratio of the D- to L-isomer was 0.78. d-dmano 46-53 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-4 23640382-5 2013 FMO1 catalyzed the formation of slightly less d-DMANO than l-DMANO, and the Clint ratio of the D- to L-isomer was 0.78. l-dmano 59-66 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-4 23640382-8 2013 Enantioselectivities in the formation of MA and DMANO in human liver microsomes were consistent with those of CYP2D6 and FMO1, respectively. dmano 48-53 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 121-125 23656565-4 2013 Dietary carnitine (present predominately in red meat) and lecithin (phosphatidyl choline) are shown to be metabolized by gut microbes to trimethylamine (TMA), which in turn is metabolized by liver flavin monoxygenases (especially FMO3 and FMO1) to form trimethylamine-N-oxide (TMAO). Carnitine 8-17 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 239-243 23930678-8 2013 The potential involvement of FMO1 and CYP3A43 in olanzapine disposition has also been suggested but needs future validation. Olanzapine 49-59 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 29-33 23656565-4 2013 Dietary carnitine (present predominately in red meat) and lecithin (phosphatidyl choline) are shown to be metabolized by gut microbes to trimethylamine (TMA), which in turn is metabolized by liver flavin monoxygenases (especially FMO3 and FMO1) to form trimethylamine-N-oxide (TMAO). Lecithins 58-66 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 239-243 23656565-4 2013 Dietary carnitine (present predominately in red meat) and lecithin (phosphatidyl choline) are shown to be metabolized by gut microbes to trimethylamine (TMA), which in turn is metabolized by liver flavin monoxygenases (especially FMO3 and FMO1) to form trimethylamine-N-oxide (TMAO). Phosphatidylcholines 68-88 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 239-243 23656565-4 2013 Dietary carnitine (present predominately in red meat) and lecithin (phosphatidyl choline) are shown to be metabolized by gut microbes to trimethylamine (TMA), which in turn is metabolized by liver flavin monoxygenases (especially FMO3 and FMO1) to form trimethylamine-N-oxide (TMAO). trimethylamine 137-151 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 239-243 23440336-10 2013 In the systemic leaves, the AGD2-LIKE DEFENSE RESPONSE PROTEIN1 (ALD1)-dependent production of the lysine catabolite pipecolic acid (Pip), FLAVIN-DEPENDENT MONOOXYGENASE1 (FMO1) signaling, as well as SA synthesis and downstream signaling are required for the activation of SAR. lysine catabolite 99-116 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 139-170 23440336-10 2013 In the systemic leaves, the AGD2-LIKE DEFENSE RESPONSE PROTEIN1 (ALD1)-dependent production of the lysine catabolite pipecolic acid (Pip), FLAVIN-DEPENDENT MONOOXYGENASE1 (FMO1) signaling, as well as SA synthesis and downstream signaling are required for the activation of SAR. lysine catabolite 99-116 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 172-176 23440336-10 2013 In the systemic leaves, the AGD2-LIKE DEFENSE RESPONSE PROTEIN1 (ALD1)-dependent production of the lysine catabolite pipecolic acid (Pip), FLAVIN-DEPENDENT MONOOXYGENASE1 (FMO1) signaling, as well as SA synthesis and downstream signaling are required for the activation of SAR. pipecolic acid 117-131 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 139-170 23440336-10 2013 In the systemic leaves, the AGD2-LIKE DEFENSE RESPONSE PROTEIN1 (ALD1)-dependent production of the lysine catabolite pipecolic acid (Pip), FLAVIN-DEPENDENT MONOOXYGENASE1 (FMO1) signaling, as well as SA synthesis and downstream signaling are required for the activation of SAR. pipecolic acid 117-131 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 172-176 23440336-10 2013 In the systemic leaves, the AGD2-LIKE DEFENSE RESPONSE PROTEIN1 (ALD1)-dependent production of the lysine catabolite pipecolic acid (Pip), FLAVIN-DEPENDENT MONOOXYGENASE1 (FMO1) signaling, as well as SA synthesis and downstream signaling are required for the activation of SAR. pipecolic acid 133-136 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 172-176 23440336-10 2013 In the systemic leaves, the AGD2-LIKE DEFENSE RESPONSE PROTEIN1 (ALD1)-dependent production of the lysine catabolite pipecolic acid (Pip), FLAVIN-DEPENDENT MONOOXYGENASE1 (FMO1) signaling, as well as SA synthesis and downstream signaling are required for the activation of SAR. Salicylic Acid 200-202 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 139-170 23440336-10 2013 In the systemic leaves, the AGD2-LIKE DEFENSE RESPONSE PROTEIN1 (ALD1)-dependent production of the lysine catabolite pipecolic acid (Pip), FLAVIN-DEPENDENT MONOOXYGENASE1 (FMO1) signaling, as well as SA synthesis and downstream signaling are required for the activation of SAR. Salicylic Acid 200-202 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 172-176 21540762-0 2011 Common polymorphisms in FMO1 are associated with nicotine dependence. Nicotine 49-57 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 24-28 23161341-3 2013 The proposed method was applied for the kinetics study of FMO1 using TAM as a substrate probe. Tamoxifen 69-72 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 58-62 23161341-5 2013 The calculated value of the maximum reaction velocity (V(max)) was 3.61 mumol/min/mumol FMO1; 50% inhibitory concentration and inhibition constant (K(i)) of MMI, the most common alternate substrate FMO inhibitor, were evaluated and the inhibitory effects of two other important FMO substrates, nicotine and DMXAA, a novel anti-tumour agent, were investigated. Nicotine 294-302 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 88-92 23161341-5 2013 The calculated value of the maximum reaction velocity (V(max)) was 3.61 mumol/min/mumol FMO1; 50% inhibitory concentration and inhibition constant (K(i)) of MMI, the most common alternate substrate FMO inhibitor, were evaluated and the inhibitory effects of two other important FMO substrates, nicotine and DMXAA, a novel anti-tumour agent, were investigated. vadimezan 307-312 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 88-92 21859392-0 2011 Flavin monooxygenases, FMO1 and FMO3, not cytochrome P450 isoenzymes, contribute to metabolism of anti-tumour triazoloacridinone, C-1305, in liver microsomes and HepG2 cells. triazoloacridinone 110-128 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 23-27 21859392-3 2011 We demonstrated that the studied triazoloacridinone was transformed with rat and human liver microsomes, HepG2 hepatoma cells and with human recombinant flavin-containing monooxygenases FMO1, FMO3 but not with CYPs. triazoloacridinone 33-51 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 186-190 21859392-8 2011 In contrast, FMO1 and FMO3 were crucial for metabolism of C-1305 by liver microsomes and in HepG2 cells, which makes C-1305 an attractive potent anti-tumour agent. C 1305 58-64 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 13-17 22387617-8 2012 Significant levels of the novel N-oxide metabolites produced by FMO1 and FMO3 in humans might be associated with the development of procainamide-induced systemic lupus erythematosus. n-oxide 32-39 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 64-68 22387617-8 2012 Significant levels of the novel N-oxide metabolites produced by FMO1 and FMO3 in humans might be associated with the development of procainamide-induced systemic lupus erythematosus. Procainamide 132-144 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 64-68 21540762-7 2011 Subsequent in-vitro experiments characterized FMO1 as a more efficient catalyst of nicotine N-oxidation than FMO3. Nicotine 83-91 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 46-50 21540762-9 2011 FMO1 is also expressed in the brain and could contribute to the nicotine concentration in this tissue. Nicotine 64-72 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-4 21540762-10 2011 CONCLUSION: These findings suggest that polymorphisms in FMO1 are significant risk factors in the development of nicotine dependence and that the mechanism may involve variation in nicotine pharmacology. Nicotine 113-121 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 57-61 21540762-10 2011 CONCLUSION: These findings suggest that polymorphisms in FMO1 are significant risk factors in the development of nicotine dependence and that the mechanism may involve variation in nicotine pharmacology. Nicotine 181-189 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 57-61 20947616-10 2011 This metabolic reaction was also inhibited by BNPP or a brief heat treatment at 50 C. Methimazole, the substrate/inhibitor of FMO1 and FMO3, did not inhibit this reaction. Methimazole 86-97 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 126-130 21226652-12 2011 Multiple enzymes including CYP2D6, CYP3A4/5, FMO1 and FMO3 catalyzed AZD0328 metabolism. spiro(1-azabicyclo(2.2.2)octane-3,2'(3H)-furo(2,3-b)pyridine) 69-76 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 45-49 20369854-0 2010 Formation of a quinoneimine intermediate of 4-fluoro-N-methylaniline by FMO1: carbon oxidation plus defluorination. quinoneimine 15-27 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 72-76 20642449-7 2010 Quinuclidine oxidation was another pathway of importance, yielding an N-oxide (M12) which was also observed in all species.P450 2D6 and FMO1 catalyze the oxidation of the quinuclidine nitrogen. Quinuclidines 0-12 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 136-140 20642449-7 2010 Quinuclidine oxidation was another pathway of importance, yielding an N-oxide (M12) which was also observed in all species.P450 2D6 and FMO1 catalyze the oxidation of the quinuclidine nitrogen. n-oxide 70-77 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 136-140 20642449-7 2010 Quinuclidine oxidation was another pathway of importance, yielding an N-oxide (M12) which was also observed in all species.P450 2D6 and FMO1 catalyze the oxidation of the quinuclidine nitrogen. Quinuclidines 171-183 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 136-140 20642449-7 2010 Quinuclidine oxidation was another pathway of importance, yielding an N-oxide (M12) which was also observed in all species.P450 2D6 and FMO1 catalyze the oxidation of the quinuclidine nitrogen. Nitrogen 184-192 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 136-140 20642449-8 2010 The N oxidation of the quinuclidine moiety is consistent with previously published accounts of this scaffold"s metabolism and, interestingly, may implicate the uncommon quinuclidine moiety as an entity directing the metabolism of this scaffold (e.g., 1) via FMO1 and P450 2D6 oxidation. Quinuclidines 23-35 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 258-262 20642449-8 2010 The N oxidation of the quinuclidine moiety is consistent with previously published accounts of this scaffold"s metabolism and, interestingly, may implicate the uncommon quinuclidine moiety as an entity directing the metabolism of this scaffold (e.g., 1) via FMO1 and P450 2D6 oxidation. Quinuclidines 169-181 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 258-262 20369854-0 2010 Formation of a quinoneimine intermediate of 4-fluoro-N-methylaniline by FMO1: carbon oxidation plus defluorination. 4-fluoro-N-methylaniline 44-68 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 72-76 20369854-0 2010 Formation of a quinoneimine intermediate of 4-fluoro-N-methylaniline by FMO1: carbon oxidation plus defluorination. Carbon 78-84 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 72-76 20369854-1 2010 Here, we report on the mechanism by which flavin-containing monooxygenase 1 (FMO1) mediates the formation of a reactive intermediate of 4-fluoro-N-methylaniline. 4-fluoro-N-methylaniline 136-160 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 42-75 20369854-1 2010 Here, we report on the mechanism by which flavin-containing monooxygenase 1 (FMO1) mediates the formation of a reactive intermediate of 4-fluoro-N-methylaniline. 4-fluoro-N-methylaniline 136-160 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 77-81 20369854-2 2010 FMO1 catalyzed a carbon oxidation reaction coupled with defluorination that led to the formation of 4-N-methylaminophenol, which was a reaction first reported by Boersma et al. Carbon 17-23 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-4 20369854-2 2010 FMO1 catalyzed a carbon oxidation reaction coupled with defluorination that led to the formation of 4-N-methylaminophenol, which was a reaction first reported by Boersma et al. N-methyl-4-aminophenol 100-121 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-4 19552509-0 2009 Flavin-containing monooxygenase 1-catalysed N,N-dimethylamphetamine N-oxidation. dimethylamphetamine 44-67 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-33 19552509-7 2009 The resulting data showed that DMA N-oxidation is mainly mediated by FMO1. dimethylamphetamine 31-34 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 69-73 19552509-6 2009 Imipramine, an FMO1-specific inhibitor, selectively inhibited DMA N-oxidation. dimethylamphetamine 62-65 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 15-19 19552509-4 2009 When DMA was incubated with different human recombinant drug-metabolizing enzymes, including FMOs and cytochrome P450s (CYPs), the formation of DMANO by FMO1 was the most predominant. dimethylamphetamine 5-8 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 153-157 19552509-4 2009 When DMA was incubated with different human recombinant drug-metabolizing enzymes, including FMOs and cytochrome P450s (CYPs), the formation of DMANO by FMO1 was the most predominant. dmano 144-149 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 153-157 19552509-5 2009 The Michaelis-Menten kinetic constants for DMA N-oxidation by FMO1 were: K(m) of 44.5 microM, V(max) of 7.59 nmol min(-1) mg(-1) protein, and intrinsic clearance of 171 microl min(-1) mg(-1) protein, which was about twelve-fold higher than that by FMO3. dimethylamphetamine 43-46 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 62-66 19552509-6 2009 Imipramine, an FMO1-specific inhibitor, selectively inhibited DMA N-oxidation. Imipramine 0-10 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 15-19 16864509-2 2006 A microtitre-based adaptation of methodology described for the thiourea-dependent oxidation of thiocholine was used to determine the turnover of thiourea-containing compounds by human FMO1 and FMO3. Thiourea 145-153 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 184-188 18948378-3 2009 The metabolites generated, the sulfenic acid, sulfinic acid, and carbodiimide derivatives, are the same as those produced by EtaA and human FMO1 and FMO3. Sulfenic Acids 31-44 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 140-144 18948378-3 2009 The metabolites generated, the sulfenic acid, sulfinic acid, and carbodiimide derivatives, are the same as those produced by EtaA and human FMO1 and FMO3. Sulfinic Acids 46-59 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 140-144 18948378-3 2009 The metabolites generated, the sulfenic acid, sulfinic acid, and carbodiimide derivatives, are the same as those produced by EtaA and human FMO1 and FMO3. Carbodiimides 65-77 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 140-144 18930751-0 2008 Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes. Ethionamide 41-52 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 72-76 18362161-9 2008 Kinetic analysis of voriconazole metabolism by FMO1 and FMO3 yielded K(m) values of 3.0 and 3.4 mM and V(max) values of 0.025 and 0.044 pmol/min/pmol, respectively. Voriconazole 20-32 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 47-51 17253727-1 2007 Earlier reports have demonstrated that recombinant flavin-containing monooxygenase 1 (FMO1) catalyzes the oxidation of the organophosphate pesticide fenthion to (+)-fenthion sulfoxide in a stereoselective fashion. Organophosphates 123-138 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 51-84 17253727-1 2007 Earlier reports have demonstrated that recombinant flavin-containing monooxygenase 1 (FMO1) catalyzes the oxidation of the organophosphate pesticide fenthion to (+)-fenthion sulfoxide in a stereoselective fashion. Organophosphates 123-138 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 86-90 17253727-1 2007 Earlier reports have demonstrated that recombinant flavin-containing monooxygenase 1 (FMO1) catalyzes the oxidation of the organophosphate pesticide fenthion to (+)-fenthion sulfoxide in a stereoselective fashion. Fenthion 149-157 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 51-84 17253727-1 2007 Earlier reports have demonstrated that recombinant flavin-containing monooxygenase 1 (FMO1) catalyzes the oxidation of the organophosphate pesticide fenthion to (+)-fenthion sulfoxide in a stereoselective fashion. Fenthion 149-157 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 86-90 17253727-1 2007 Earlier reports have demonstrated that recombinant flavin-containing monooxygenase 1 (FMO1) catalyzes the oxidation of the organophosphate pesticide fenthion to (+)-fenthion sulfoxide in a stereoselective fashion. (+)-fenthion sulfoxide 161-183 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 51-84 17253727-1 2007 Earlier reports have demonstrated that recombinant flavin-containing monooxygenase 1 (FMO1) catalyzes the oxidation of the organophosphate pesticide fenthion to (+)-fenthion sulfoxide in a stereoselective fashion. (+)-fenthion sulfoxide 161-183 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 86-90 17253727-5 2007 The absolute configuration of the (+)-sulfoxide generated from fenthion metabolism by FMO1 was determined to be (R)-(+)-fenthion sulfoxide, confirmed by X-ray crystallographic analysis of the (S)-(-)-antipode. sulfoxide 34-47 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 86-90 17253727-5 2007 The absolute configuration of the (+)-sulfoxide generated from fenthion metabolism by FMO1 was determined to be (R)-(+)-fenthion sulfoxide, confirmed by X-ray crystallographic analysis of the (S)-(-)-antipode. Fenthion 63-71 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 86-90 17253727-5 2007 The absolute configuration of the (+)-sulfoxide generated from fenthion metabolism by FMO1 was determined to be (R)-(+)-fenthion sulfoxide, confirmed by X-ray crystallographic analysis of the (S)-(-)-antipode. (r)-(+)-fenthion sulfoxide 112-138 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 86-90 17253727-5 2007 The absolute configuration of the (+)-sulfoxide generated from fenthion metabolism by FMO1 was determined to be (R)-(+)-fenthion sulfoxide, confirmed by X-ray crystallographic analysis of the (S)-(-)-antipode. (s)-(-)-antipode 192-208 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 86-90 16864509-0 2006 Bioactivation of N-substituted N"-(4-imidazole-ethyl)thioureas by human FMO1 and FMO3. n-substituted n"-(4-imidazole-ethyl)thioureas 17-62 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 72-76 16864509-1 2006 Enzyme kinetic parameters of the bioactivation of thiourea-containing compounds by human flavin-containing monooxygenase enzymes (FMOs) FMO1 and FMO3 were investigated. Thiourea 50-58 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 136-140 16864509-2 2006 A microtitre-based adaptation of methodology described for the thiourea-dependent oxidation of thiocholine was used to determine the turnover of thiourea-containing compounds by human FMO1 and FMO3. Thiourea 63-71 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 184-188 19283698-7 2009 FMO1 produces more (-)-CSO-enantiomer, while FMO3 generates mainly (+)-CSO-enantiomer. cimetidine sulfoxide 19-26 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-4 19283698-10 2009 A K(m)=4.31 mM for the formation of the (+)-CSO-enantiomer and a K(m)=4.56 mM for the (-)-CSO-enantiomer are reported for the first time for FMO1. cimetidine sulfoxide 40-47 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 141-145 19283698-10 2009 A K(m)=4.31 mM for the formation of the (+)-CSO-enantiomer and a K(m)=4.56 mM for the (-)-CSO-enantiomer are reported for the first time for FMO1. cimetidine sulfoxide 86-93 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 141-145 16985102-8 2006 Human Pro360-FMO1 was significantly more catalytically efficient at S-oxygenating mercaptoimidazole and chlorpromazine compared with wild-type FMO1. 2-mercaptoimidazole 82-99 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 13-17 16985102-8 2006 Human Pro360-FMO1 was significantly more catalytically efficient at S-oxygenating mercaptoimidazole and chlorpromazine compared with wild-type FMO1. Chlorpromazine 104-118 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 13-17 16985102-12 2006 The increase in catalytic efficiency observed for Pro360 in human FMO3 was also observed when the His of FMO1 was replaced by Pro at loci 360. Histidine 98-101 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 105-109 16985102-12 2006 The increase in catalytic efficiency observed for Pro360 in human FMO3 was also observed when the His of FMO1 was replaced by Pro at loci 360. Proline 50-53 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 105-109 16857727-5 2006 In addition, recombinant FMO1 and FMO3 were able to bioactivate both SMX and DDS, resulting in covalent adduct formation. Sulfamethoxazole 69-72 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 25-29 16857727-5 2006 In addition, recombinant FMO1 and FMO3 were able to bioactivate both SMX and DDS, resulting in covalent adduct formation. Fumigant 93 77-80 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 25-29 16864509-2 2006 A microtitre-based adaptation of methodology described for the thiourea-dependent oxidation of thiocholine was used to determine the turnover of thiourea-containing compounds by human FMO1 and FMO3. Thiocholine 95-106 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 184-188 16864509-3 2006 The results show that major differences in enzyme kinetic parameters for N-substituted N"-(4-imidazole-ethyl)thiourea exist between human FMO3 and human FMO1. n-substituted n"-(4-imidazole-ethyl)thiourea 73-117 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 153-157 16864509-5 2006 Furthermore, among a series of N-p-phenyl-substituted N"-(4-imidazole-ethyl)thioureas an interesting structure-activity relationship is evident with both FMO1 and FMO3. n-p-phenyl-substituted n"-(4-imidazole-ethyl)thioureas 31-85 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 154-158 16864509-8 2006 Enzyme kinetic parameters Km and kcat/Km of human FMO1 for N-substituted N"-(4-imidazole-ethyl)thioureas show a high degree of correlation with the results obtained in rat liver microsomes, in which rat FMO1 is the most abundant form, whereas those of human FMO3 do not. n-substituted n"-(4-imidazole-ethyl)thioureas 59-104 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 50-54 16684653-8 2006 We collaborated with Dr. Kupfer"s laboratory and recently determined that the low level of tamoxifen N-oxide production in human liver microsomes may be explained by the kinetics of FMO1 versus FMO3. tamoxifen N-oxide 91-108 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 182-186 16544950-0 2006 Oxidative activation of thiacetazone by the Mycobacterium tuberculosis flavin monooxygenase EtaA and human FMO1 and FMO3. Thioacetazone 24-36 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 107-111 15352021-10 2004 FMO1, the extrahepatic form of the enzyme in man, was shown to be more active in the N-oxygenation of both deprenyl and methamphetamine isomers than FMO3. Nitrogen 85-86 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-4 15987777-0 2005 Oxidation of tamoxifen by human flavin-containing monooxygenase (FMO) 1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochromes P450 and hemoglobin. Tamoxifen 13-22 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 32-71 15987777-0 2005 Oxidation of tamoxifen by human flavin-containing monooxygenase (FMO) 1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochromes P450 and hemoglobin. tamoxifen N-oxide 84-101 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 32-71 15987777-0 2005 Oxidation of tamoxifen by human flavin-containing monooxygenase (FMO) 1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochromes P450 and hemoglobin. Tamoxifen 84-93 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 32-71 15987777-3 2005 The current study demonstrates that human FMO1 and FMO3 catalyze TAM N-oxidation to TNO and that cytochromes P450 (P450s), but not FMOs, reduce TNO to TAM. Tamoxifen 65-68 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 42-46 15680226-3 2005 Previous work from this laboratory has shown l-methionine to be S-oxidized by rat, rabbit and human FMO1-4, with FMO3 exhibiting the highest stereoselectivity for the formation of the d-diastereomer of methionine sulfoxide. Methionine 45-57 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 100-106 15465034-2 2004 mRNA levels of the major hepatic form, FMO1, decreased via a cGMP-independent destabilizing effect of NO rather than by decreased transcription. Cyclic GMP 61-65 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 39-43 15352021-10 2004 FMO1, the extrahepatic form of the enzyme in man, was shown to be more active in the N-oxygenation of both deprenyl and methamphetamine isomers than FMO3. Selegiline 107-115 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-4 15352021-10 2004 FMO1, the extrahepatic form of the enzyme in man, was shown to be more active in the N-oxygenation of both deprenyl and methamphetamine isomers than FMO3. Methamphetamine 120-135 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-4 16719389-2 2006 Prochiral sulfoxidation of probe compounds based on p-tolyl methyl sulfide is a particularly useful method for discriminating among FMO1, FMO3, and FMO5, because the stereochemistry of the resulting products is isoform dependent, but apparently species independent. dimethyl sulfide 60-74 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 132-136 15547051-11 2005 The relative contribution of FMO1 and FMO3 to the sulfoxidation of carbophenothion, demeton-O, ethiofencarb, fonofos, and methiocarb also was investigated by using baculovirus-expressed recombinant proteins. carbophenothion 67-82 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 29-33 15547051-11 2005 The relative contribution of FMO1 and FMO3 to the sulfoxidation of carbophenothion, demeton-O, ethiofencarb, fonofos, and methiocarb also was investigated by using baculovirus-expressed recombinant proteins. Demeton-O 84-93 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 29-33 15547051-11 2005 The relative contribution of FMO1 and FMO3 to the sulfoxidation of carbophenothion, demeton-O, ethiofencarb, fonofos, and methiocarb also was investigated by using baculovirus-expressed recombinant proteins. Fonofos 109-116 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 29-33 12642475-9 2003 Upon incubation of tazarotenic acid with microsomes expressing CYP2C8, flavin-containing monooxygenase 1 (FMO1), or FMO3, marked formation of the sulfoxide metabolite was observed. tazarotenic acid 19-35 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 71-104 14976351-0 2004 Evaluation of xenobiotic N- and S-oxidation by variant flavin-containing monooxygenase 1 (FMO1) enzymes. Nitrogen 25-26 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 55-88 14976351-0 2004 Evaluation of xenobiotic N- and S-oxidation by variant flavin-containing monooxygenase 1 (FMO1) enzymes. Nitrogen 25-26 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 90-94 14976351-5 2004 The I303V variant showed catalytic constants equal to wild-type FMO1 for methimazole and methyl p-tolyl sulfide. Methimazole 73-84 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 64-68 14976351-5 2004 The I303V variant showed catalytic constants equal to wild-type FMO1 for methimazole and methyl p-tolyl sulfide. methyl 4-tolylsulfide 89-111 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 64-68 14976351-9 2004 All the variants demonstrated the same stereoselectivity for methyl p-tolyl sulfide oxidation as wild-type FMO1. methyl 4-tolylsulfide 61-83 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 107-111 14976351-10 2004 FMO1 also metabolized the commonly used insecticide fenthion to its (+)-sulfoxide, with relatively high catalytic efficiency. Fenthion 52-60 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-4 14976351-10 2004 FMO1 also metabolized the commonly used insecticide fenthion to its (+)-sulfoxide, with relatively high catalytic efficiency. sulfoxide 68-81 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-4 14742144-10 2003 In contrast, methimazole was effective in suppressing the catalytic activity of recombinant human FMO1 and FMO3. Methimazole 13-24 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 98-102 12642475-9 2003 Upon incubation of tazarotenic acid with microsomes expressing CYP2C8, flavin-containing monooxygenase 1 (FMO1), or FMO3, marked formation of the sulfoxide metabolite was observed. tazarotenic acid 19-35 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 106-110 12642475-9 2003 Upon incubation of tazarotenic acid with microsomes expressing CYP2C8, flavin-containing monooxygenase 1 (FMO1), or FMO3, marked formation of the sulfoxide metabolite was observed. sulfoxide 146-155 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 71-104 12642475-9 2003 Upon incubation of tazarotenic acid with microsomes expressing CYP2C8, flavin-containing monooxygenase 1 (FMO1), or FMO3, marked formation of the sulfoxide metabolite was observed. sulfoxide 146-155 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 106-110 11725960-8 2001 In addition, microsomes containing cDNA-expressed FMO1, a major isoform in human kidney, mainly catalyzed N-oxidation of SNI-2011, but microsomes containing FMO3, a major isoform in adult human liver, did not. Nitrogen 37-38 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 50-54 12490590-2 2003 Incubations of human cDNA-expressed FMO1, FMO3, FMO4, and FMO5 with SAC resulted in detection of SAC sulfoxide, with FMO3 exhibiting approximately 3-, 4-, and 10-fold higher activity than FMO1, FMO4, and FMO5, respectively. sulfoxide 101-110 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 36-40 12084621-4 2002 Three flavin monooxygenase isozymes (FMO1, FMO3, and FMO5) with NADPH are not active as assayed. NADP 64-69 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 37-41 11465082-3 2000 Human FMO3 N-oxygenates primary, secondary and tertiary amines whereas human FMO1 is only highly efficient at N-oxygenating tertiary amines. Amines 133-139 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 77-81 11159801-6 2001 MeDDC sulfine was formed at 5 microM MeDDC by renal microsomes at a rate of 210 +/- 50 pmol/min/mg of microsomal protein (mean +/- S.D., n = 5) and by FMO1 at 7.6 +/- 0.2 nmol/min/nmol (n = 3). Sulfine 6-13 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 151-155 11159801-11 2001 The K(M) values for MeDDC sulfine formation by renal microsomes and recombinant human FMO1 were 11 and 15 microM, respectively. S-methyl-N,N-diethyldithiocarbamate sulfine 20-33 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 86-90 11465082-3 2000 Human FMO3 N-oxygenates primary, secondary and tertiary amines whereas human FMO1 is only highly efficient at N-oxygenating tertiary amines. Nitrogen 11-12 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 77-81 11012553-7 2000 In contrast, benzydamine was a substrate for human FMO1, FMO3, FMO4 and FMO5. Benzydamine 13-24 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 51-55 11012553-8 2000 Apparent Km values for benzydamine N-oxygenation were 60 +/- 8 microM, 80 +/- 8 microM, > 3 mM and > 2 mM, for FMO1, FMO3, FMO4 and FMO5, respectively. Benzydamine 23-34 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 117-121 11012553-11 2000 CONCLUSIONS: FMO1 and FMO3 catalyse benzydamine N-oxygenation with the highest efficiency. benzydamine n 36-49 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 13-17 11128045-3 2000 Recombinant FMO isozymes like FMO1, FMO2, FMO3 and FMO5 produced 39, 79, 2180 and 4 ranitinine N-oxide and 45, 0, 580 and 280 ranitinine S-oxide pmol x min(-1) x nmol(-1) FMO, respectively. ranitinine n-oxide 84-102 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 30-34 11128045-3 2000 Recombinant FMO isozymes like FMO1, FMO2, FMO3 and FMO5 produced 39, 79, 2180 and 4 ranitinine N-oxide and 45, 0, 580 and 280 ranitinine S-oxide pmol x min(-1) x nmol(-1) FMO, respectively. ranitinine s-oxide 126-144 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 30-34 11465082-3 2000 Human FMO3 N-oxygenates primary, secondary and tertiary amines whereas human FMO1 is only highly efficient at N-oxygenating tertiary amines. Amines 56-62 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 77-81 11465082-4 2000 Both human FMO1 and FMO3 S-oxygenate a number of nucleophilic sulfur-containing substrates and in some cases, does so with great stereoselectivity. Sulfur 62-68 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 11-15 10901713-0 2000 Size limits of thiocarbamides accepted as substrates by human flavin-containing monooxygenase 1. Thiourea 15-29 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 62-95 10950857-5 2000 Recombinant human FMO1 and detergent-solubilized human duodenal microsomes both metabolized p-tolyl methyl sulfide stereoselectively to the (R)-sulfoxide, indicating the expression of functional FMO1 in human intestine. methyl 4-tolylsulfide 92-114 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 18-22 10950857-5 2000 Recombinant human FMO1 and detergent-solubilized human duodenal microsomes both metabolized p-tolyl methyl sulfide stereoselectively to the (R)-sulfoxide, indicating the expression of functional FMO1 in human intestine. (r)-sulfoxide 140-153 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 18-22 10950857-5 2000 Recombinant human FMO1 and detergent-solubilized human duodenal microsomes both metabolized p-tolyl methyl sulfide stereoselectively to the (R)-sulfoxide, indicating the expression of functional FMO1 in human intestine. (r)-sulfoxide 140-153 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 195-199 10950857-6 2000 The relatively high levels of immunoquantifiable FMO1 in human kidney and fetal liver complement our previous catalytic studies in these tissues, which also demonstrated preferential (R)-p-tolyl methyl sulfoxide formation. (r)-p-tolyl methyl sulfoxide 183-211 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 49-53 10950857-8 2000 The marked expression levels of FMO1 found in human kidney coupled to the high catalytic activity of this isoform toward a diverse array of sulfides and tertiary amines suggest the possibility that human renal FMO1 is a significant contributor to the metabolic clearance of drugs and other xenobiotics bearing these functionalities. Sulfides 140-148 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 32-36 10950857-8 2000 The marked expression levels of FMO1 found in human kidney coupled to the high catalytic activity of this isoform toward a diverse array of sulfides and tertiary amines suggest the possibility that human renal FMO1 is a significant contributor to the metabolic clearance of drugs and other xenobiotics bearing these functionalities. Sulfides 140-148 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 210-214 10950857-8 2000 The marked expression levels of FMO1 found in human kidney coupled to the high catalytic activity of this isoform toward a diverse array of sulfides and tertiary amines suggest the possibility that human renal FMO1 is a significant contributor to the metabolic clearance of drugs and other xenobiotics bearing these functionalities. Amines 162-168 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 32-36 10950857-8 2000 The marked expression levels of FMO1 found in human kidney coupled to the high catalytic activity of this isoform toward a diverse array of sulfides and tertiary amines suggest the possibility that human renal FMO1 is a significant contributor to the metabolic clearance of drugs and other xenobiotics bearing these functionalities. Amines 162-168 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 210-214 11128045-7 2000 FMO1, expressed primarily in human kidney, was 55- and 13-fold less efficient than the hepatic FMO3 in producing ranitidine N- and S-oxides, respectively. ranitidine n- and s-oxides 113-139 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 0-4 10901713-6 2000 Because 1,3-diphenylthiourea is apparently completely excluded from the catalytic site, tricyclic amine drugs are probably approaching the upper size limits of xenobiotics accepted by human FMO1. diphenylthiourea 8-28 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 190-194 10901713-1 2000 Microsomes isolated from Spodoptera frugiperda (Sf)9 cells infected with human flavin-containing monooxygenase (FMO)1 recombinant baculovirus catalyzed the NADPH- and O2-dependent oxidation of methimazole, thiourea, and phenylthiourea. NADP 156-161 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 79-117 10901713-6 2000 Because 1,3-diphenylthiourea is apparently completely excluded from the catalytic site, tricyclic amine drugs are probably approaching the upper size limits of xenobiotics accepted by human FMO1. tricyclic amine 88-103 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 190-194 10901713-1 2000 Microsomes isolated from Spodoptera frugiperda (Sf)9 cells infected with human flavin-containing monooxygenase (FMO)1 recombinant baculovirus catalyzed the NADPH- and O2-dependent oxidation of methimazole, thiourea, and phenylthiourea. Oxygen 167-169 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 79-117 10901713-1 2000 Microsomes isolated from Spodoptera frugiperda (Sf)9 cells infected with human flavin-containing monooxygenase (FMO)1 recombinant baculovirus catalyzed the NADPH- and O2-dependent oxidation of methimazole, thiourea, and phenylthiourea. Methimazole 193-204 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 79-117 10901713-1 2000 Microsomes isolated from Spodoptera frugiperda (Sf)9 cells infected with human flavin-containing monooxygenase (FMO)1 recombinant baculovirus catalyzed the NADPH- and O2-dependent oxidation of methimazole, thiourea, and phenylthiourea. Thiourea 206-214 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 79-117 10901713-1 2000 Microsomes isolated from Spodoptera frugiperda (Sf)9 cells infected with human flavin-containing monooxygenase (FMO)1 recombinant baculovirus catalyzed the NADPH- and O2-dependent oxidation of methimazole, thiourea, and phenylthiourea. Phenylthiourea 220-234 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 79-117 10901713-5 2000 Although products were not isolated, the pronounced inhibition of methimazole S-oxygenation suggests that these amines are alternate substrates for human FMO1. Methimazole 66-77 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 154-158 10901713-5 2000 Although products were not isolated, the pronounced inhibition of methimazole S-oxygenation suggests that these amines are alternate substrates for human FMO1. Amines 112-118 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 154-158 10630426-1 2000 The Km value for tamoxifen is 1.2 mM for mouse FMO1 (human FMO1 is not expressed in adults) and 1.4 mM for human FMO3, with no detectable activity being expressed toward tamoxifen by FMO5 from either mouse or human. Tamoxifen 17-26 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 59-63 9316835-1 1997 The biogenic amine phenethylamine has been shown to be N-oxygenated by human flavin-containing monooxygenase (FMO) (form 3) and human liver microsomes and, to a much lesser extent, N-oxygenated by porcine liver FMO1 and porcine liver microsomes but not by rabbit FMO2. Amines 13-18 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 211-215 9316835-1 1997 The biogenic amine phenethylamine has been shown to be N-oxygenated by human flavin-containing monooxygenase (FMO) (form 3) and human liver microsomes and, to a much lesser extent, N-oxygenated by porcine liver FMO1 and porcine liver microsomes but not by rabbit FMO2. phenethylamine 19-33 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 211-215