PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33579899-8	2021	Furthermore, ALOXE3 silencing promoted 12-hydroxyeicosatetraenoic acids (12-HETE) secretion from GBM cells, in turn, 12-HETE enhanced migration of GBM cells by activating Gs-protein-coupled receptor (GsPCR)-PI3K-Akt pathway in an autocrine manner.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	39-71	arachidonate lipoxygenase 3	Mus musculus	13-19
33579899-8	2021	Furthermore, ALOXE3 silencing promoted 12-hydroxyeicosatetraenoic acids (12-HETE) secretion from GBM cells, in turn, 12-HETE enhanced migration of GBM cells by activating Gs-protein-coupled receptor (GsPCR)-PI3K-Akt pathway in an autocrine manner.	Hydroxyeicosatetraenoic Acids	75-80	arachidonate lipoxygenase 3	Mus musculus	13-19
33058074-8	2022	In fact, decreased expression of ALOXE3 and elevated concentration of AA in the hippocampus was found after status epilepticus (SE) induced by pilocarpine.	Pilocarpine	143-154	arachidonate lipoxygenase 3	Mus musculus	33-39
33334892-7	2021	We conclude EPHX3 (and not EPHX1 or EPHX2) catalyzes hydrolysis of the 12R-LOX/eLOX3-derived epoxyalcohol esterified in acylceramide, and may function to control flux through the alternative and crucial route of metabolism via the dehydrogenation pathway of SDR9C7.	epoxyalcohol esterified	93-116	arachidonate lipoxygenase 3	Mus musculus	79-84
33334892-7	2021	We conclude EPHX3 (and not EPHX1 or EPHX2) catalyzes hydrolysis of the 12R-LOX/eLOX3-derived epoxyalcohol esterified in acylceramide, and may function to control flux through the alternative and crucial route of metabolism via the dehydrogenation pathway of SDR9C7.	acylceramide	120-132	arachidonate lipoxygenase 3	Mus musculus	79-84
21558561-4	2011	Here we show using HPLC-UV, LC-MS, GC-MS, and (1)H NMR that O-linoleoyl-omega-hydroxyceramide is oxygenated in a regio- and stereospecific fashion by the consecutive actions of 12R-LOX and eLOX3 and that these products occur naturally in pig and mouse epidermis.	o-linoleoyl-omega-hydroxyceramide	60-93	arachidonate lipoxygenase 3	Mus musculus	189-194
30135298-4	2018	We show that Aloxe3 is activated during fasting, glucose withdrawal, or trehalose/trehalose analogue treatment.	Trehalose	72-81	arachidonate lipoxygenase 3	Mus musculus	13-19
30135298-4	2018	We show that Aloxe3 is activated during fasting, glucose withdrawal, or trehalose/trehalose analogue treatment.	Trehalose	82-91	arachidonate lipoxygenase 3	Mus musculus	13-19
30135298-7	2018	Targeted metabolomics demonstrated accumulation of the PPARgamma ligand 12-KETE in hepatocytes overexpressing Aloxe3.	12-keto-5,8,11,13-eicosatetraenoic acid	72-79	arachidonate lipoxygenase 3	Mus musculus	110-116
30135298-8	2018	Strikingly, PPARgamma inhibition reversed hepatic Aloxe3-mediated insulin sensitization, suppression of hepatocellular ATP production and oxygen consumption, and gene induction of PPARgamma coactivator-1alpha (PGC1alpha) expression.	Adenosine Triphosphate	119-122	arachidonate lipoxygenase 3	Mus musculus	50-56
30135298-8	2018	Strikingly, PPARgamma inhibition reversed hepatic Aloxe3-mediated insulin sensitization, suppression of hepatocellular ATP production and oxygen consumption, and gene induction of PPARgamma coactivator-1alpha (PGC1alpha) expression.	Oxygen	138-144	arachidonate lipoxygenase 3	Mus musculus	50-56
25043671-3	2014	Periodic acid-Schiff staining and RT-PCR analysis of placentae from fetuses exposed to eLOX-3 indicated a lack of glycogen trophoblasts in the junctional zone.	Periodic Acid	0-13	arachidonate lipoxygenase 3	Mus musculus	87-93
25043671-3	2014	Periodic acid-Schiff staining and RT-PCR analysis of placentae from fetuses exposed to eLOX-3 indicated a lack of glycogen trophoblasts in the junctional zone.	schiff	14-20	arachidonate lipoxygenase 3	Mus musculus	87-93
25043671-3	2014	Periodic acid-Schiff staining and RT-PCR analysis of placentae from fetuses exposed to eLOX-3 indicated a lack of glycogen trophoblasts in the junctional zone.	Glycogen	114-122	arachidonate lipoxygenase 3	Mus musculus	87-93
22832496-2	2013	The encoded proteins, 12R-LOX and epidermal LOX-3 (eLOX-3), act in sequence to convert fatty acid substrates via R-hydroperoxides to specific epoxyalcohol derivatives and have been proposed to operate in the same metabolic pathway during epidermal barrier formation.	Fatty Acids	87-97	arachidonate lipoxygenase 3	Mus musculus	34-49
22832496-2	2013	The encoded proteins, 12R-LOX and epidermal LOX-3 (eLOX-3), act in sequence to convert fatty acid substrates via R-hydroperoxides to specific epoxyalcohol derivatives and have been proposed to operate in the same metabolic pathway during epidermal barrier formation.	Fatty Acids	87-97	arachidonate lipoxygenase 3	Mus musculus	51-57
22832496-2	2013	The encoded proteins, 12R-LOX and epidermal LOX-3 (eLOX-3), act in sequence to convert fatty acid substrates via R-hydroperoxides to specific epoxyalcohol derivatives and have been proposed to operate in the same metabolic pathway during epidermal barrier formation.	r-hydroperoxides	113-129	arachidonate lipoxygenase 3	Mus musculus	34-49
22832496-2	2013	The encoded proteins, 12R-LOX and epidermal LOX-3 (eLOX-3), act in sequence to convert fatty acid substrates via R-hydroperoxides to specific epoxyalcohol derivatives and have been proposed to operate in the same metabolic pathway during epidermal barrier formation.	r-hydroperoxides	113-129	arachidonate lipoxygenase 3	Mus musculus	51-57
22832496-2	2013	The encoded proteins, 12R-LOX and epidermal LOX-3 (eLOX-3), act in sequence to convert fatty acid substrates via R-hydroperoxides to specific epoxyalcohol derivatives and have been proposed to operate in the same metabolic pathway during epidermal barrier formation.	epoxyalcohol	142-154	arachidonate lipoxygenase 3	Mus musculus	34-49
22832496-2	2013	The encoded proteins, 12R-LOX and epidermal LOX-3 (eLOX-3), act in sequence to convert fatty acid substrates via R-hydroperoxides to specific epoxyalcohol derivatives and have been proposed to operate in the same metabolic pathway during epidermal barrier formation.	epoxyalcohol	142-154	arachidonate lipoxygenase 3	Mus musculus	51-57
21558561-5	2011	12R-LOX forms 9R-hydroperoxy-linoleoyl-omega-hydroxyceramide, further converted by eLOX3 to specific epoxyalcohol (9R,10R-trans-epoxy-11E-13R-hydroxy) and 9-keto-10E,12Z esters of the ceramide; an epoxy-ketone derivative (9R,10R-trans-epoxy-11E-13-keto) is the most prominent oxidized ceramide in mouse skin.	epoxyalcohol	101-113	arachidonate lipoxygenase 3	Mus musculus	83-88
21558561-5	2011	12R-LOX forms 9R-hydroperoxy-linoleoyl-omega-hydroxyceramide, further converted by eLOX3 to specific epoxyalcohol (9R,10R-trans-epoxy-11E-13R-hydroxy) and 9-keto-10E,12Z esters of the ceramide; an epoxy-ketone derivative (9R,10R-trans-epoxy-11E-13-keto) is the most prominent oxidized ceramide in mouse skin.	,10r-trans-epoxy-11e-13r-hydroxy	117-149	arachidonate lipoxygenase 3	Mus musculus	83-88
21558561-5	2011	12R-LOX forms 9R-hydroperoxy-linoleoyl-omega-hydroxyceramide, further converted by eLOX3 to specific epoxyalcohol (9R,10R-trans-epoxy-11E-13R-hydroxy) and 9-keto-10E,12Z esters of the ceramide; an epoxy-ketone derivative (9R,10R-trans-epoxy-11E-13-keto) is the most prominent oxidized ceramide in mouse skin.	9-keto-10e	155-165	arachidonate lipoxygenase 3	Mus musculus	83-88
21558561-5	2011	12R-LOX forms 9R-hydroperoxy-linoleoyl-omega-hydroxyceramide, further converted by eLOX3 to specific epoxyalcohol (9R,10R-trans-epoxy-11E-13R-hydroxy) and 9-keto-10E,12Z esters of the ceramide; an epoxy-ketone derivative (9R,10R-trans-epoxy-11E-13-keto) is the most prominent oxidized ceramide in mouse skin.	12z esters	166-176	arachidonate lipoxygenase 3	Mus musculus	83-88
21558561-5	2011	12R-LOX forms 9R-hydroperoxy-linoleoyl-omega-hydroxyceramide, further converted by eLOX3 to specific epoxyalcohol (9R,10R-trans-epoxy-11E-13R-hydroxy) and 9-keto-10E,12Z esters of the ceramide; an epoxy-ketone derivative (9R,10R-trans-epoxy-11E-13-keto) is the most prominent oxidized ceramide in mouse skin.	Ceramides	52-60	arachidonate lipoxygenase 3	Mus musculus	83-88
21558561-5	2011	12R-LOX forms 9R-hydroperoxy-linoleoyl-omega-hydroxyceramide, further converted by eLOX3 to specific epoxyalcohol (9R,10R-trans-epoxy-11E-13R-hydroxy) and 9-keto-10E,12Z esters of the ceramide; an epoxy-ketone derivative (9R,10R-trans-epoxy-11E-13-keto) is the most prominent oxidized ceramide in mouse skin.	epoxy-ketone	197-209	arachidonate lipoxygenase 3	Mus musculus	83-88
21558561-5	2011	12R-LOX forms 9R-hydroperoxy-linoleoyl-omega-hydroxyceramide, further converted by eLOX3 to specific epoxyalcohol (9R,10R-trans-epoxy-11E-13R-hydroxy) and 9-keto-10E,12Z esters of the ceramide; an epoxy-ketone derivative (9R,10R-trans-epoxy-11E-13-keto) is the most prominent oxidized ceramide in mouse skin.	-trans-epoxy-11e-13-keto	228-252	arachidonate lipoxygenase 3	Mus musculus	83-88
21558561-5	2011	12R-LOX forms 9R-hydroperoxy-linoleoyl-omega-hydroxyceramide, further converted by eLOX3 to specific epoxyalcohol (9R,10R-trans-epoxy-11E-13R-hydroxy) and 9-keto-10E,12Z esters of the ceramide; an epoxy-ketone derivative (9R,10R-trans-epoxy-11E-13-keto) is the most prominent oxidized ceramide in mouse skin.	Ceramides	184-192	arachidonate lipoxygenase 3	Mus musculus	83-88
20530198-6	2010	Hepoxilins, a group of oxidized arachidonic acid derivatives produced by eLOX3, bound to and activated PPAR gamma.	hepoxilins	0-10	arachidonate lipoxygenase 3	Mus musculus	73-78
20530198-6	2010	Hepoxilins, a group of oxidized arachidonic acid derivatives produced by eLOX3, bound to and activated PPAR gamma.	Arachidonic Acid	32-48	arachidonate lipoxygenase 3	Mus musculus	73-78
17045234-5	2006	Whereas 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) is the best substrate for human eLOX3 (2.4 s(-1); at 30 microM substrate), mouse eLOX3 shows the highest turnover with 8R-HPETE (2.9 s(-1)) followed by 8S-HPETE (1.3 s(-1)).	12R-HpETE	46-55	arachidonate lipoxygenase 3	Mus musculus	138-143
17045234-5	2006	Whereas 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) is the best substrate for human eLOX3 (2.4 s(-1); at 30 microM substrate), mouse eLOX3 shows the highest turnover with 8R-HPETE (2.9 s(-1)) followed by 8S-HPETE (1.3 s(-1)).	8R-HpETE	176-184	arachidonate lipoxygenase 3	Mus musculus	138-143
17045234-5	2006	Whereas 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) is the best substrate for human eLOX3 (2.4 s(-1); at 30 microM substrate), mouse eLOX3 shows the highest turnover with 8R-HPETE (2.9 s(-1)) followed by 8S-HPETE (1.3 s(-1)).	8-hydroperoxyeicosatetraenoic acid	209-217	arachidonate lipoxygenase 3	Mus musculus	138-143
17045234-8	2006	The substrate preference of mouse eLOX3 and the unique occurrence of an 8S-LOX enzyme in mouse skin point to a potential LOX pathway for the production of epoxyalcohol in murine epidermal differentiation.	epoxyalcohol	155-167	arachidonate lipoxygenase 3	Mus musculus	34-39