PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 30586912-2 2018 However, since alpha-tocopherol transfer protein (alpha-TTP) has been shown to be a determinant of vitamin E level in circulation, manipulation of alpha-tocopherol levels by alpha-TTP inhibition was considered as a potential therapeutic strategy for malaria. Vitamin E 99-108 tocopherol (alpha) transfer protein Mus musculus 15-48 33733036-0 2021 Natural and Synthetic alpha-Tocopherol Modulate the Neuroinflammatory Response in the Spinal Cord of Adult Ttpa-null Mice. alpha-Tocopherol 22-38 tocopherol (alpha) transfer protein Mus musculus 107-111 33733036-9 2021 alpha-T concentrations were increased in NAT (4.6 +- 0.3 nmol/g), SYN (8.0 +- 0.7 nmol/g), and HSYN (8.5 +- 0.3 nmol/g) mice, but were significantly lower than in Ttpa+/+ mice fed CON (27.8 +- 1.9 nmol/g) (P < 0.001). 1,1,1-trichloroethane 0-7 tocopherol (alpha) transfer protein Mus musculus 163-167 33733036-13 2021 Conclusions: Natural and synthetic alpha-T supplementation normalized neuroinflammatory markers in neural tissues of 10-mo-old Ttpa- / - mice. 1,1,1-trichloroethane 35-42 tocopherol (alpha) transfer protein Mus musculus 127-131 33086686-0 2020 alpha-Tocomonoenol Is Bioavailable in Mice and May Partly Be Regulated by the Function of the Hepatic alpha-Tocopherol Transfer Protein. alpha-tocomonoenol 0-18 tocopherol (alpha) transfer protein Mus musculus 102-135 33086686-2 2020 The alpha-tocopherol transfer protein (TTP) is required for the maintenance of normal alpha-tocopherol (alphaT) concentrations. alpha-Tocopherol 104-110 tocopherol (alpha) transfer protein Mus musculus 4-37 31883016-0 2020 Synthetic alpha-Tocopherol, Compared with Natural alpha-Tocopherol, Downregulates Myelin Genes in Cerebella of Adolescent Ttpa-null Mice. alpha-Tocopherol 10-26 tocopherol (alpha) transfer protein Mus musculus 122-126 30586912-2 2018 However, since alpha-tocopherol transfer protein (alpha-TTP) has been shown to be a determinant of vitamin E level in circulation, manipulation of alpha-tocopherol levels by alpha-TTP inhibition was considered as a potential therapeutic strategy for malaria. Vitamin E 99-108 tocopherol (alpha) transfer protein Mus musculus 50-59 30586912-2 2018 However, since alpha-tocopherol transfer protein (alpha-TTP) has been shown to be a determinant of vitamin E level in circulation, manipulation of alpha-tocopherol levels by alpha-TTP inhibition was considered as a potential therapeutic strategy for malaria. alpha-Tocopherol 15-31 tocopherol (alpha) transfer protein Mus musculus 50-59 26893162-3 2017 Moreover, we examined protein and mRNA expression levels of hepatic alpha-tocopherol transfer protein (alpha-TTP), which specifically binds alpha-tocopherol, during aging. alpha-Tocopherol 68-84 tocopherol (alpha) transfer protein Mus musculus 103-112 28159772-6 2017 METHODS AND RESULTS: Using genome-wide gene expression analysis in a mouse model of ventilator-induced lung injury, we discovered a previously unsuspected mechanism by which CO2 can protect against injury: induction of the transporter protein for alpha-tocopherol, alpha-tocopherol transfer protein (alphaTTP). N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 174-177 tocopherol (alpha) transfer protein Mus musculus 300-308 28159772-6 2017 METHODS AND RESULTS: Using genome-wide gene expression analysis in a mouse model of ventilator-induced lung injury, we discovered a previously unsuspected mechanism by which CO2 can protect against injury: induction of the transporter protein for alpha-tocopherol, alpha-tocopherol transfer protein (alphaTTP). alpha-Tocopherol 247-263 tocopherol (alpha) transfer protein Mus musculus 300-308 28159772-7 2017 Pulmonary alphaTTP was induced by inspired CO2 in two in vivo murine models of ventilator-induced lung injury; the level of alphaTTP expression correlated with degree of lung protection; and, absence of the alphaTTP gene significantly reduced the protective effects of CO2. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 43-46 tocopherol (alpha) transfer protein Mus musculus 10-18 28159772-7 2017 Pulmonary alphaTTP was induced by inspired CO2 in two in vivo murine models of ventilator-induced lung injury; the level of alphaTTP expression correlated with degree of lung protection; and, absence of the alphaTTP gene significantly reduced the protective effects of CO2. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 269-272 tocopherol (alpha) transfer protein Mus musculus 10-18 28159772-9 2017 In concordance with a regulatory role for alpha-tocopherol in lipid mediator synthesis, hypercapnia attenuated 5-lipoxygenase activity and this was dependent on the presence of alphaTTP. alpha-Tocopherol 42-58 tocopherol (alpha) transfer protein Mus musculus 177-185 28159772-10 2017 CONCLUSIONS: Inspired CO2 upregulates alphaTTP which increases lung alpha-tocopherol levels and inhibits synthesis of a pathogenic chemoattractant. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 22-25 tocopherol (alpha) transfer protein Mus musculus 38-46 28159772-10 2017 CONCLUSIONS: Inspired CO2 upregulates alphaTTP which increases lung alpha-tocopherol levels and inhibits synthesis of a pathogenic chemoattractant. alpha-Tocopherol 68-84 tocopherol (alpha) transfer protein Mus musculus 38-46 29526809-0 2018 An innate immune response and altered nuclear receptor activation defines the spinal cord transcriptome during alpha-tocopherol deficiency in Ttpa-null mice. alpha-Tocopherol 111-127 tocopherol (alpha) transfer protein Mus musculus 142-146 29526809-2 2018 Ttpa-/- mice maintained on diets with deficient alpha-tocopherol (alpha-TOH) had proprioceptive deficits by six months of age, axonal degeneration and neuronal chromatolysis within the dorsal column of the spinal cord and its projections into the medulla. alpha-Tocopherol 48-64 tocopherol (alpha) transfer protein Mus musculus 0-4 29526809-2 2018 Ttpa-/- mice maintained on diets with deficient alpha-tocopherol (alpha-TOH) had proprioceptive deficits by six months of age, axonal degeneration and neuronal chromatolysis within the dorsal column of the spinal cord and its projections into the medulla. alpha-Tocopherol 66-75 tocopherol (alpha) transfer protein Mus musculus 0-4 29526809-5 2018 RNA-sequencing of the spinal cord in Ttpa-/- mice revealed upregulation of genes associated with the innate immune response, indicating a molecular signature of microglial activation as a result of tocopherol deficiency. Tocopherols 198-208 tocopherol (alpha) transfer protein Mus musculus 37-41 26637123-2 2015 We previously reported that Alzheimer disease (AD) model mice showed decreased insulin-degrading enzyme (IDE) levels in the cerebrum and accelerated phenotypic features of AD when crossbred with alpha-tocopherol transfer protein knockout (Ttpa-/-) mice. alpha-Tocopherol 195-211 tocopherol (alpha) transfer protein Mus musculus 239-243 24420818-6 2014 The preferential degradation of gammaT independently of TTP expression was confirmed and a decrease in the production of the metabolite gamma-carboxyethyl hydroxychromanol (CEHC) with increasing TTP expression revealed. gamma-carboxyethyl-hydroxychromanol 136-171 tocopherol (alpha) transfer protein Mus musculus 195-198 24420818-6 2014 The preferential degradation of gammaT independently of TTP expression was confirmed and a decrease in the production of the metabolite gamma-carboxyethyl hydroxychromanol (CEHC) with increasing TTP expression revealed. cehc 173-177 tocopherol (alpha) transfer protein Mus musculus 195-198 24420818-8 2014 CONCLUSIONS: We conclude that vitamin E metabolism and not TTP controls gammaT concentrations in vivo and observed an interaction of TTP with vitamin E metabolism that results in reduced production of the metabolite gamma-CEHC. Vitamin E 142-151 tocopherol (alpha) transfer protein Mus musculus 133-136 24420818-8 2014 CONCLUSIONS: We conclude that vitamin E metabolism and not TTP controls gammaT concentrations in vivo and observed an interaction of TTP with vitamin E metabolism that results in reduced production of the metabolite gamma-CEHC. 2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman 216-226 tocopherol (alpha) transfer protein Mus musculus 133-136 24342566-4 2014 When fed vitamin E-deficient diet, Ttpa(-/)(-) mice had un-detectable levels of alpha-tocopherol in plasma and several brain regions. Vitamin E 9-18 tocopherol (alpha) transfer protein Mus musculus 35-39 24342566-5 2014 Dietary supplementation with alpha-tocopherol normalized plasma levels of the vitamin, but only modestly increased its levels in the cerebellum and prefrontal cortex, indicating a critical function of brain TTP. alpha-Tocopherol 29-45 tocopherol (alpha) transfer protein Mus musculus 207-210 26098482-10 2014 Oral Ge-132 intake may therefore have increased plasma alpha-tocopherol levels by up-regulating alpha-tocopherol transfer protein (Ttpa) gene expression. alpha-Tocopherol 55-71 tocopherol (alpha) transfer protein Mus musculus 131-135 24363183-2 2014 Previously, we have reported that alpha-tocopherol transfer protein knockout (alpha-ttp(Delta)) mice, showing low concentrations of alpha-tocopherol in circulation, infected with Plasmodium berghei NK65 survived significantly longer as compared with the wild-type mice. alpha-Tocopherol 34-50 tocopherol (alpha) transfer protein Mus musculus 78-95 19555225-1 2010 Alpha-tocopherol transfer protein (ATTP) null mice (ATTP-/-) have a systemic alpha-tocopherol (AT) deficiency, with their lung AT levels being < 10% of those in AT-replete ATTP(+/+) mice when fed a standard rodent chow diet. alpha-Tocopherol 77-93 tocopherol (alpha) transfer protein Mus musculus 0-33 22147702-7 2012 Similarly, alpha-TTP knockout mice showed more severe CQ toxicity, such as hepatotoxicity and retinopathy, than wild-type mice. Chloroquine 54-56 tocopherol (alpha) transfer protein Mus musculus 11-20 20403155-8 2010 RESULTS: Inhibition of alpha-tocopherol transfer protein (alpha-TTP), a determinant of vitamin E concentration in circulation, confers resistance to malarial infection as a result of oxidative damage to the parasites. Vitamin E 87-96 tocopherol (alpha) transfer protein Mus musculus 23-56 20403155-8 2010 RESULTS: Inhibition of alpha-tocopherol transfer protein (alpha-TTP), a determinant of vitamin E concentration in circulation, confers resistance to malarial infection as a result of oxidative damage to the parasites. Vitamin E 87-96 tocopherol (alpha) transfer protein Mus musculus 58-67 20187127-5 2010 The cloning of alphaTTP gene and the creation of alphaTTP-knockout mice allowed to achieve severe systemic alphaT deficiency in brain and muscles, possibly at birth, eliminating the possible confounding effects of ex vivo-generated oxidant products in vitamin E-stripped diets. Vitamin E 252-261 tocopherol (alpha) transfer protein Mus musculus 49-57 19555225-1 2010 Alpha-tocopherol transfer protein (ATTP) null mice (ATTP-/-) have a systemic alpha-tocopherol (AT) deficiency, with their lung AT levels being < 10% of those in AT-replete ATTP(+/+) mice when fed a standard rodent chow diet. alpha-Tocopherol 77-93 tocopherol (alpha) transfer protein Mus musculus 35-39 19555225-1 2010 Alpha-tocopherol transfer protein (ATTP) null mice (ATTP-/-) have a systemic alpha-tocopherol (AT) deficiency, with their lung AT levels being < 10% of those in AT-replete ATTP(+/+) mice when fed a standard rodent chow diet. alpha-Tocopherol 77-93 tocopherol (alpha) transfer protein Mus musculus 52-56 19555225-1 2010 Alpha-tocopherol transfer protein (ATTP) null mice (ATTP-/-) have a systemic alpha-tocopherol (AT) deficiency, with their lung AT levels being < 10% of those in AT-replete ATTP(+/+) mice when fed a standard rodent chow diet. alpha-Tocopherol 77-93 tocopherol (alpha) transfer protein Mus musculus 52-56 19555225-5 2010 As compared with filtered air exposure, O(3) exposure resulted in 99 genes being differentially expressed in ATTP(-/-) mice, as compared to 52 differentially expressed genes in ATTP(+/+) mice. Ozone 40-44 tocopherol (alpha) transfer protein Mus musculus 109-113 19555225-6 2010 The data revealed an O(3)-induced upregulation of genes related to cell proliferation/DNA repair and inflammatory-immune responses in both ATTP(+/+) and ATTP(-/-) mice, with the expression of 22 genes being common to both, whereas 30 and 77 genes were unique to ATTP(+/+) and ATTP(-/-) mice, respectively. Ozone 21-25 tocopherol (alpha) transfer protein Mus musculus 139-143 19555225-6 2010 The data revealed an O(3)-induced upregulation of genes related to cell proliferation/DNA repair and inflammatory-immune responses in both ATTP(+/+) and ATTP(-/-) mice, with the expression of 22 genes being common to both, whereas 30 and 77 genes were unique to ATTP(+/+) and ATTP(-/-) mice, respectively. Ozone 21-25 tocopherol (alpha) transfer protein Mus musculus 153-157 19555225-6 2010 The data revealed an O(3)-induced upregulation of genes related to cell proliferation/DNA repair and inflammatory-immune responses in both ATTP(+/+) and ATTP(-/-) mice, with the expression of 22 genes being common to both, whereas 30 and 77 genes were unique to ATTP(+/+) and ATTP(-/-) mice, respectively. Ozone 21-25 tocopherol (alpha) transfer protein Mus musculus 153-157 19555225-6 2010 The data revealed an O(3)-induced upregulation of genes related to cell proliferation/DNA repair and inflammatory-immune responses in both ATTP(+/+) and ATTP(-/-) mice, with the expression of 22 genes being common to both, whereas 30 and 77 genes were unique to ATTP(+/+) and ATTP(-/-) mice, respectively. Ozone 21-25 tocopherol (alpha) transfer protein Mus musculus 153-157 20533246-0 2010 Conjugated linoleic acid causes a marked increase in liver alpha-tocopherol and liver alpha-tocopherol transfer protein in C57BL/6 J mice. Linoleic Acid 11-24 tocopherol (alpha) transfer protein Mus musculus 86-119 20533246-2 2010 The aims of the present study were to evaluate whether levels of hepatic alpha-tocopherol, alpha-tocopherol transfer protein (alpha-TTP), and antioxidant enzymes in mice were affected by a CLA-supplemented diet. Linoleic Acids, Conjugated 189-192 tocopherol (alpha) transfer protein Mus musculus 91-124 20533246-2 2010 The aims of the present study were to evaluate whether levels of hepatic alpha-tocopherol, alpha-tocopherol transfer protein (alpha-TTP), and antioxidant enzymes in mice were affected by a CLA-supplemented diet. Linoleic Acids, Conjugated 189-192 tocopherol (alpha) transfer protein Mus musculus 126-135 20533246-8 2010 The accumulation of liver alpha-tocopherol seen with the CLA diet can be attributed to the antioxidant potential of CLA and the ability of alpha-TTP induction. alpha-Tocopherol 26-42 tocopherol (alpha) transfer protein Mus musculus 139-148 20533246-8 2010 The accumulation of liver alpha-tocopherol seen with the CLA diet can be attributed to the antioxidant potential of CLA and the ability of alpha-TTP induction. Linoleic Acids, Conjugated 57-60 tocopherol (alpha) transfer protein Mus musculus 139-148 18299118-7 2008 The concentration of another endogenous antioxidant, total glutathione, was unaffected by gender but was decreased slightly but significantly in most brain regions of alpha-TTP-KO mice. Glutathione 59-70 tocopherol (alpha) transfer protein Mus musculus 167-176 19923370-7 2010 Interestingly, protection of the blood-brain barrier in these infected alpha-TTP knockout mice was lost when dietary supplementation with vitamin E was added to their diet. Vitamin E 138-147 tocopherol (alpha) transfer protein Mus musculus 71-80 19923370-9 2010 CONCLUSION: It appears that a deficiency of alpha-tocopherol in the circulation prevents CM and suggests that alpha-TTP is a putative target for the early prevention of CM. alpha-Tocopherol 44-60 tocopherol (alpha) transfer protein Mus musculus 110-119 19679659-3 2009 The resulting double-mutant (Ttpa(-/-)APPsw) mice showed increased amyloid beta (Abeta) deposits in the brain, which was ameliorated with alpha-tocopherol supplementation. alpha-Tocopherol 138-154 tocopherol (alpha) transfer protein Mus musculus 29-33 19679659-9 2009 These results suggest that lipid peroxidation due to depletion of alpha-tocopherol impairs Abeta clearances from the brain and from the blood, possibly causing increased Abeta accumulation in Ttpa(-/-)APPsw mouse brain and plasma. alpha-Tocopherol 66-82 tocopherol (alpha) transfer protein Mus musculus 192-196 14871478-1 2004 The liver preferentially secretes alpha-tocopherol into plasma under the control of the hepatic alpha-tocopherol transfer protein (alpha-TTP). alpha-Tocopherol 34-50 tocopherol (alpha) transfer protein Mus musculus 96-129 17882348-0 2007 Improved glucose metabolism in mice lacking alpha-tocopherol transfer protein. Glucose 9-16 tocopherol (alpha) transfer protein Mus musculus 44-77 17882348-2 2007 The alpha-tocopherol transfer protein (alpha-TTP) mediates the transfer of alpha-tocopherol (alpha-TOH) from hepatocytes to very-low-density lipoproteins, thereby controlling plasma levels of alpha-TOH. alpha-Tocopherol 4-20 tocopherol (alpha) transfer protein Mus musculus 39-48 17882348-2 2007 The alpha-tocopherol transfer protein (alpha-TTP) mediates the transfer of alpha-tocopherol (alpha-TOH) from hepatocytes to very-low-density lipoproteins, thereby controlling plasma levels of alpha-TOH. alpha-Tocopherol 93-102 tocopherol (alpha) transfer protein Mus musculus 4-37 17882348-2 2007 The alpha-tocopherol transfer protein (alpha-TTP) mediates the transfer of alpha-tocopherol (alpha-TOH) from hepatocytes to very-low-density lipoproteins, thereby controlling plasma levels of alpha-TOH. alpha-Tocopherol 93-102 tocopherol (alpha) transfer protein Mus musculus 39-48 17882348-2 2007 The alpha-tocopherol transfer protein (alpha-TTP) mediates the transfer of alpha-tocopherol (alpha-TOH) from hepatocytes to very-low-density lipoproteins, thereby controlling plasma levels of alpha-TOH. alpha-Tocopherol 192-201 tocopherol (alpha) transfer protein Mus musculus 4-37 17882348-2 2007 The alpha-tocopherol transfer protein (alpha-TTP) mediates the transfer of alpha-tocopherol (alpha-TOH) from hepatocytes to very-low-density lipoproteins, thereby controlling plasma levels of alpha-TOH. alpha-Tocopherol 192-201 tocopherol (alpha) transfer protein Mus musculus 39-48 17882348-3 2007 AIM OF THE STUDY: The aim of this study was to investigate the putative impact of alpha-TTP knock-out on glucose metabolism in mice. Glucose 105-112 tocopherol (alpha) transfer protein Mus musculus 82-91 17882348-8 2007 Unexpectedly, serum glucose levels both in the fasted and in the fed state were lower in alpha-TTP-deficient mice at any age. Glucose 20-27 tocopherol (alpha) transfer protein Mus musculus 89-98 17882348-9 2007 Removal rates for intraperitoneally injected glucose were found to be significantly increased in young alpha-TTP-deficient mice. Glucose 45-52 tocopherol (alpha) transfer protein Mus musculus 103-112 17882348-10 2007 This improved glucose tolerance was caused by increased insulin secretion in response to an intraperitoneal glucose challenge due to an increased number of pancreatic islets, as well as by increased sensitivity to intraperitoneally injected insulin, both significantly promoting glucose metabolism in alpha-TTP-deficient mice. Glucose 14-21 tocopherol (alpha) transfer protein Mus musculus 301-310 20368946-1 2007 Alpha-tocopherol transfer protein (alpha-TTP) is a liver cytosolic transport protein that faciliates alpha-tocopherol (alpha-T) transfer into liver secreted plasma lipoproteins. alpha-Tocopherol 101-117 tocopherol (alpha) transfer protein Mus musculus 0-33 20368946-1 2007 Alpha-tocopherol transfer protein (alpha-TTP) is a liver cytosolic transport protein that faciliates alpha-tocopherol (alpha-T) transfer into liver secreted plasma lipoproteins. alpha-Tocopherol 101-117 tocopherol (alpha) transfer protein Mus musculus 35-44 17026966-3 2006 We previously generated alpha-tocopherol transfer protein knockout (Ttpa-/-) mice, in which lipid peroxidation in the brain was significantly increased by complete depletion of alpha-tocopherol (alpha-Toc). alpha-Tocopherol 24-40 tocopherol (alpha) transfer protein Mus musculus 68-72 17026966-5 2006 The resulting double-mutant (Ttpa-/- APPsw) mice showed earlier and more severe cognitive dysfunction in the Morris water maze, novel-object recognition, and contextual fear conditioning tests. Water 116-121 tocopherol (alpha) transfer protein Mus musculus 29-33 16014812-4 2005 A dietary supplement of alpha-tocopherol to pregnant Ttpa-/- (homozygous null) mice was shown to be essential for maintenance of pregnancy from 6.5 to 13.5 days postcoitum but found not to be crucial before or after this time span, which corresponds to initial development and maturation of the placenta. alpha-Tocopherol 24-40 tocopherol (alpha) transfer protein Mus musculus 53-57 16014812-6 2005 When Ttpa(-/-)-fertilized eggs were transferred into Ttpa+/+ (wild-type) recipients, plasma alpha-tocopherol concentrations in the Ttpa-/- fetuses were below the detection limit but the fetuses grew normally. alpha-Tocopherol 92-108 tocopherol (alpha) transfer protein Mus musculus 5-9 18781058-0 2008 Acceleration of lipid peroxidation in alpha-tocopherol transfer protein-knockout mice following the consumption of drinking water containing a radical initiator. Water 124-129 tocopherol (alpha) transfer protein Mus musculus 38-71 17382327-0 2007 Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP(-/-)). alpha-Tocopherol 25-41 tocopherol (alpha) transfer protein Mus musculus 79-112 17382327-0 2007 Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP(-/-)). alpha-Tocopherol 25-41 tocopherol (alpha) transfer protein Mus musculus 124-128 17382327-1 2007 Alpha-tocopherol transfer protein (ATTP) null mice (ATTP(-/-)) have a systemic deficiency of alpha-tocopherol (AT). alpha-Tocopherol 93-109 tocopherol (alpha) transfer protein Mus musculus 0-33 17382327-1 2007 Alpha-tocopherol transfer protein (ATTP) null mice (ATTP(-/-)) have a systemic deficiency of alpha-tocopherol (AT). alpha-Tocopherol 93-109 tocopherol (alpha) transfer protein Mus musculus 35-39 17382327-1 2007 Alpha-tocopherol transfer protein (ATTP) null mice (ATTP(-/-)) have a systemic deficiency of alpha-tocopherol (AT). alpha-Tocopherol 93-109 tocopherol (alpha) transfer protein Mus musculus 52-56 16895792-7 2006 Here we confirm this finding and report that in Apoe(-/-)Ttpa(-/-) mice dietary alpha-tocopherol (alphaT) supplements restored circulating and aortic levels of alphaT, and decreased atherosclerosis in the aortic root to a level comparable to that seen in Apoe(-/-) mice. alpha-Tocopherol 80-96 tocopherol (alpha) transfer protein Mus musculus 57-61 16716512-3 2006 The intraperitoneal administration of MPTP to mice induced a decrease in the striatal levels of dopamine (DA) 3 days after the administration in both alpha-TTP((+/-)) and wild-type mice; these mice were fed an alphaT-deficient diet for 3 weeks before the MPTP administration. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 38-42 tocopherol (alpha) transfer protein Mus musculus 150-159 16716512-3 2006 The intraperitoneal administration of MPTP to mice induced a decrease in the striatal levels of dopamine (DA) 3 days after the administration in both alpha-TTP((+/-)) and wild-type mice; these mice were fed an alphaT-deficient diet for 3 weeks before the MPTP administration. Dopamine 96-104 tocopherol (alpha) transfer protein Mus musculus 150-159 16716512-3 2006 The intraperitoneal administration of MPTP to mice induced a decrease in the striatal levels of dopamine (DA) 3 days after the administration in both alpha-TTP((+/-)) and wild-type mice; these mice were fed an alphaT-deficient diet for 3 weeks before the MPTP administration. Dopamine 106-108 tocopherol (alpha) transfer protein Mus musculus 150-159 17707975-1 2006 The alpha-tocopherol transfer protein (TTP) plays an important role in the regulation of plasma alpha-tocopherol concentrations. alpha-Tocopherol 4-20 tocopherol (alpha) transfer protein Mus musculus 39-42 17707975-2 2006 We hypothesized that hepatic TTP levels would be modulated by dietary vitamin E supplementation and/or by oxidative stress. Vitamin E 70-79 tocopherol (alpha) transfer protein Mus musculus 29-32 14871478-1 2004 The liver preferentially secretes alpha-tocopherol into plasma under the control of the hepatic alpha-tocopherol transfer protein (alpha-TTP). alpha-Tocopherol 34-50 tocopherol (alpha) transfer protein Mus musculus 131-140 14871478-2 2004 alpha-TTP-null mice (Ttpa(-/-) mice) are vitamin E deficient, therefore were used for investigations of in vivo responses to sub-normal tissue alpha-tocopherol concentrations during inflammation. Vitamin E 41-50 tocopherol (alpha) transfer protein Mus musculus 0-9 14871478-3 2004 Increased basal oxidative stress in Ttpa(-/-) mice was documented by increased plasma lipid peroxidation, and superoxide production by bone marrow-derived neutrophils stimulated in vitro with phorbol 12-myristate 13-acetate. Superoxides 110-120 tocopherol (alpha) transfer protein Mus musculus 36-40 14871478-3 2004 Increased basal oxidative stress in Ttpa(-/-) mice was documented by increased plasma lipid peroxidation, and superoxide production by bone marrow-derived neutrophils stimulated in vitro with phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 192-223 tocopherol (alpha) transfer protein Mus musculus 36-40 14642382-1 2003 Alpha-tocopherol transfer protein (TTP) regulates the retention and secretion of alpha-tocopherol (alpha-T) by the liver. alpha-Tocopherol 81-97 tocopherol (alpha) transfer protein Mus musculus 0-33 14642382-1 2003 Alpha-tocopherol transfer protein (TTP) regulates the retention and secretion of alpha-tocopherol (alpha-T) by the liver. alpha-Tocopherol 81-97 tocopherol (alpha) transfer protein Mus musculus 35-38 14642382-1 2003 Alpha-tocopherol transfer protein (TTP) regulates the retention and secretion of alpha-tocopherol (alpha-T) by the liver. alpha-Tocopherol 99-106 tocopherol (alpha) transfer protein Mus musculus 0-33 14642382-1 2003 Alpha-tocopherol transfer protein (TTP) regulates the retention and secretion of alpha-tocopherol (alpha-T) by the liver. alpha-Tocopherol 99-106 tocopherol (alpha) transfer protein Mus musculus 35-38 11752462-1 2001 alpha-Tocopherol transfer protein (alpha-TTP) maintains the concentration of serum alpha-tocopherol (vitamin E), one of the most potent fat-soluble antioxidants, by facilitating alpha-tocopherol export from the liver. alpha-Tocopherol 83-99 tocopherol (alpha) transfer protein Mus musculus 0-33 12135902-1 2002 Alpha-tocopherol transfer protein (alpha-TTP) was first described to play a major role in maintaining alpha-tocopherol levels in plasma, while alpha-tocopherol was primarily reported to be a factor relevant for reproduction. alpha-Tocopherol 102-118 tocopherol (alpha) transfer protein Mus musculus 0-33 12135902-1 2002 Alpha-tocopherol transfer protein (alpha-TTP) was first described to play a major role in maintaining alpha-tocopherol levels in plasma, while alpha-tocopherol was primarily reported to be a factor relevant for reproduction. alpha-Tocopherol 102-118 tocopherol (alpha) transfer protein Mus musculus 35-44 12135902-6 2002 It is suggested that alpha-TTP plays a major role in supplying the placenta and consecutively the fetus with alpha-tocopherol throughout pregnancy. alpha-Tocopherol 109-125 tocopherol (alpha) transfer protein Mus musculus 21-30 11864863-10 2002 CONCLUSION: Deletion of the alpha-TTP gene in mice results in an accumulation of dietary alpha-tocopherol in the liver and depletion of peripheral tissue alpha-tocopherol. alpha-Tocopherol 89-105 tocopherol (alpha) transfer protein Mus musculus 28-37 11864863-10 2002 CONCLUSION: Deletion of the alpha-TTP gene in mice results in an accumulation of dietary alpha-tocopherol in the liver and depletion of peripheral tissue alpha-tocopherol. alpha-Tocopherol 154-170 tocopherol (alpha) transfer protein Mus musculus 28-37 12135902-7 2002 We conclude that alpha-tocopherol plays a role in the process of implantation and that alpha-TTP may be necessary for adequate alpha-tocopherol status of the fetus. alpha-Tocopherol 127-143 tocopherol (alpha) transfer protein Mus musculus 87-96 11864863-7 2002 In the Ttpa(-/-) mice, low total alpha-tocopherol concentrations were found in plasma (5.4%) and most other tissues (2-20%), but liver concentrations were 39% of those of Ttpa(+/+) mice. alpha-Tocopherol 33-49 tocopherol (alpha) transfer protein Mus musculus 7-11 11752462-1 2001 alpha-Tocopherol transfer protein (alpha-TTP) maintains the concentration of serum alpha-tocopherol (vitamin E), one of the most potent fat-soluble antioxidants, by facilitating alpha-tocopherol export from the liver. alpha-Tocopherol 83-99 tocopherol (alpha) transfer protein Mus musculus 35-44 11752462-1 2001 alpha-Tocopherol transfer protein (alpha-TTP) maintains the concentration of serum alpha-tocopherol (vitamin E), one of the most potent fat-soluble antioxidants, by facilitating alpha-tocopherol export from the liver. Vitamin E 101-110 tocopherol (alpha) transfer protein Mus musculus 0-33 11752462-1 2001 alpha-Tocopherol transfer protein (alpha-TTP) maintains the concentration of serum alpha-tocopherol (vitamin E), one of the most potent fat-soluble antioxidants, by facilitating alpha-tocopherol export from the liver. Vitamin E 101-110 tocopherol (alpha) transfer protein Mus musculus 35-44 11752462-1 2001 alpha-Tocopherol transfer protein (alpha-TTP) maintains the concentration of serum alpha-tocopherol (vitamin E), one of the most potent fat-soluble antioxidants, by facilitating alpha-tocopherol export from the liver. alpha-Tocopherol 178-194 tocopherol (alpha) transfer protein Mus musculus 0-33 11752462-1 2001 alpha-Tocopherol transfer protein (alpha-TTP) maintains the concentration of serum alpha-tocopherol (vitamin E), one of the most potent fat-soluble antioxidants, by facilitating alpha-tocopherol export from the liver. alpha-Tocopherol 178-194 tocopherol (alpha) transfer protein Mus musculus 35-44 11752462-4 2001 Because the brain alpha-TTP functions in maintaining alpha-tocopherol levels in the brain, alpha-tocopherol was completely depleted in the alpha-TTP(-/-) mouse brain, and the neurological phenotype of alpha-TTP(-/-) mice is much more severe than that of wild-type mice when maintained on an alpha-tocopherol-deficient diet. alpha-Tocopherol 53-69 tocopherol (alpha) transfer protein Mus musculus 18-27 11752462-4 2001 Because the brain alpha-TTP functions in maintaining alpha-tocopherol levels in the brain, alpha-tocopherol was completely depleted in the alpha-TTP(-/-) mouse brain, and the neurological phenotype of alpha-TTP(-/-) mice is much more severe than that of wild-type mice when maintained on an alpha-tocopherol-deficient diet. alpha-Tocopherol 91-107 tocopherol (alpha) transfer protein Mus musculus 18-27 11752462-4 2001 Because the brain alpha-TTP functions in maintaining alpha-tocopherol levels in the brain, alpha-tocopherol was completely depleted in the alpha-TTP(-/-) mouse brain, and the neurological phenotype of alpha-TTP(-/-) mice is much more severe than that of wild-type mice when maintained on an alpha-tocopherol-deficient diet. alpha-Tocopherol 91-107 tocopherol (alpha) transfer protein Mus musculus 139-148 11752462-4 2001 Because the brain alpha-TTP functions in maintaining alpha-tocopherol levels in the brain, alpha-tocopherol was completely depleted in the alpha-TTP(-/-) mouse brain, and the neurological phenotype of alpha-TTP(-/-) mice is much more severe than that of wild-type mice when maintained on an alpha-tocopherol-deficient diet. alpha-Tocopherol 91-107 tocopherol (alpha) transfer protein Mus musculus 139-148 11752462-4 2001 Because the brain alpha-TTP functions in maintaining alpha-tocopherol levels in the brain, alpha-tocopherol was completely depleted in the alpha-TTP(-/-) mouse brain, and the neurological phenotype of alpha-TTP(-/-) mice is much more severe than that of wild-type mice when maintained on an alpha-tocopherol-deficient diet. alpha-Tocopherol 91-107 tocopherol (alpha) transfer protein Mus musculus 18-27 11752462-4 2001 Because the brain alpha-TTP functions in maintaining alpha-tocopherol levels in the brain, alpha-tocopherol was completely depleted in the alpha-TTP(-/-) mouse brain, and the neurological phenotype of alpha-TTP(-/-) mice is much more severe than that of wild-type mice when maintained on an alpha-tocopherol-deficient diet. alpha-Tocopherol 91-107 tocopherol (alpha) transfer protein Mus musculus 139-148 11752462-4 2001 Because the brain alpha-TTP functions in maintaining alpha-tocopherol levels in the brain, alpha-tocopherol was completely depleted in the alpha-TTP(-/-) mouse brain, and the neurological phenotype of alpha-TTP(-/-) mice is much more severe than that of wild-type mice when maintained on an alpha-tocopherol-deficient diet. alpha-Tocopherol 91-107 tocopherol (alpha) transfer protein Mus musculus 139-148 11076932-2 2001 Targeted disruption of the alpha-TTP gene revealed that alpha-tocopherol concentration in the circulation was regulated by alpha-TTP expression levels. alpha-Tocopherol 56-72 tocopherol (alpha) transfer protein Mus musculus 27-36 11076932-2 2001 Targeted disruption of the alpha-TTP gene revealed that alpha-tocopherol concentration in the circulation was regulated by alpha-TTP expression levels. alpha-Tocopherol 56-72 tocopherol (alpha) transfer protein Mus musculus 123-132 11076932-4 2001 The use of excess alpha-tocopherol or a synthetic antioxidant (BO-653) dietary supplement by alpha-TTP(-/-) females prevented placental failure and allowed full-term pregnancies. alpha-Tocopherol 18-34 tocopherol (alpha) transfer protein Mus musculus 93-102 11076932-4 2001 The use of excess alpha-tocopherol or a synthetic antioxidant (BO-653) dietary supplement by alpha-TTP(-/-) females prevented placental failure and allowed full-term pregnancies. boron oxide 63-65 tocopherol (alpha) transfer protein Mus musculus 93-102 11076932-6 2001 Our results suggest that oxidative stress in the labyrinth region of the placenta is protected by vitamin E during development and that in addition to the hepatic alpha-TTP, which governs plasma alpha-tocopherol level, the uterine alpha-TTP may also play an important role in supplying this vitamin. alpha-Tocopherol 195-211 tocopherol (alpha) transfer protein Mus musculus 163-172