PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
9188509-8	1997	Kinetic analysis of MAT II in extracts of PHA- and SEB-stimulated cells using reciprocal kinetic plots revealed that in the absence of the beta subunit the Km of the enzyme for L-methionine (L-Met) was 3-fold higher than in the presence of the beta subunit.	Methionine	177-189	methionine adenosyltransferase 2B	Homo sapiens	20-26
9281316-1	1997	The effect of the polyamines, putrescine, spermine, and spermidine, on the activity of extrahepatic methionine adenosyltransferase (MAT II) was studied.	Polyamines	18-28	methionine adenosyltransferase 2B	Homo sapiens	132-138
9281316-1	1997	The effect of the polyamines, putrescine, spermine, and spermidine, on the activity of extrahepatic methionine adenosyltransferase (MAT II) was studied.	Putrescine	30-40	methionine adenosyltransferase 2B	Homo sapiens	132-138
9281316-1	1997	The effect of the polyamines, putrescine, spermine, and spermidine, on the activity of extrahepatic methionine adenosyltransferase (MAT II) was studied.	Spermine	42-50	methionine adenosyltransferase 2B	Homo sapiens	132-138
9281316-1	1997	The effect of the polyamines, putrescine, spermine, and spermidine, on the activity of extrahepatic methionine adenosyltransferase (MAT II) was studied.	Spermidine	56-66	methionine adenosyltransferase 2B	Homo sapiens	132-138
9281316-2	1997	The polyamines inhibited MAT II activity at concentrations equal to or greater than 5 mm.	Polyamines	4-14	methionine adenosyltransferase 2B	Homo sapiens	25-31
9188509-8	1997	Kinetic analysis of MAT II in extracts of PHA- and SEB-stimulated cells using reciprocal kinetic plots revealed that in the absence of the beta subunit the Km of the enzyme for L-methionine (L-Met) was 3-fold higher than in the presence of the beta subunit.	Methionine	191-196	methionine adenosyltransferase 2B	Homo sapiens	20-26
9188509-11	1997	The data suggest that the beta subunit of MAT II, which has no catalytic activity, may be a regulatory subunit that imparts a lower Km for L-Met but increases the sensitivity to feedback inhibition by AdoMet.	Methionine	139-144	methionine adenosyltransferase 2B	Homo sapiens	42-48
34783058-7	2022	Changes in gene expressions (OCT3/4, NANOG, DMNT1, DNMT3A, and DNMT3B, MAT2A, and MAT2B) with methionine supplementation were examined by quantitative real-time polymerase chain reaction and the changes in histone methylation (H3K4me3, H3K27me3) levels were demonstrated by western blot analysis.	Methionine	94-104	methionine adenosyltransferase 2B	Homo sapiens	82-87
34783058-11	2022	On the other hand, UCB-MSCs were found to increase OCT3/4, NANOG, and DNMT1 gene expressions and decrease MAT2A and MAT2B expressions in the culture medium containing 10 microM methionine.	Methionine	177-187	methionine adenosyltransferase 2B	Homo sapiens	116-121
34783058-13	2022	In addition, OCT3/4, NANOG, DNMT1, and MAT2B gene expressions in CSCs increased starting from the addition of 25 microM methionine.	Methionine	120-130	methionine adenosyltransferase 2B	Homo sapiens	39-44
32467667-11	2020	Stable knockdown of circ-MAT2B dramatically inhibited GC cell viability, colony formation, DNA synthesis, glucose uptake and lactate production in vitro, and retarded tumor growth in vivo.	Glucose	106-113	methionine adenosyltransferase 2B	Homo sapiens	25-30
33273451-6	2020	The conversion of key enzymes of methionine metabolism methionine adenosyltransferase (MAT) 1 A and MAT2A/MAT2B is closely related to fibrosis and hepatocellular carcinoma.	Methionine	33-43	methionine adenosyltransferase 2B	Homo sapiens	106-111
33000151-1	2020	Metabolism of excess methionine (Met) to homocysteine (Hcy) by transmethylation is facilitated by the expression of methionine adenosyltransferase (MAT) I/III and glycine N-methyltransferase (GNMT) in liver, and a lack of either enzyme results in hypermethioninemia despite normal concentrations of MATII and methyltransferases other than GNMT.	Methionine	21-31	methionine adenosyltransferase 2B	Homo sapiens	299-304
33000151-1	2020	Metabolism of excess methionine (Met) to homocysteine (Hcy) by transmethylation is facilitated by the expression of methionine adenosyltransferase (MAT) I/III and glycine N-methyltransferase (GNMT) in liver, and a lack of either enzyme results in hypermethioninemia despite normal concentrations of MATII and methyltransferases other than GNMT.	Homocysteine	41-53	methionine adenosyltransferase 2B	Homo sapiens	299-304
33000151-1	2020	Metabolism of excess methionine (Met) to homocysteine (Hcy) by transmethylation is facilitated by the expression of methionine adenosyltransferase (MAT) I/III and glycine N-methyltransferase (GNMT) in liver, and a lack of either enzyme results in hypermethioninemia despite normal concentrations of MATII and methyltransferases other than GNMT.	Homocysteine	55-58	methionine adenosyltransferase 2B	Homo sapiens	299-304
32467667-11	2020	Stable knockdown of circ-MAT2B dramatically inhibited GC cell viability, colony formation, DNA synthesis, glucose uptake and lactate production in vitro, and retarded tumor growth in vivo.	Lactic Acid	125-132	methionine adenosyltransferase 2B	Homo sapiens	25-30
23189196-1	2012	Mammalian methionine adenosyltransferase II (MAT II) is the only hetero-oligomer in this family of enzymes that synthesize S-adenosylmethionine using methionine and ATP as substrates.	Methionine	10-20	methionine adenosyltransferase 2B	Homo sapiens	45-51
29170720-5	2017	A third gene MAT2B, encodes a regulatory subunit beta, that regulates the activity of MATII by lowering the inhibition constant (Ki) for SAMe and the Michaelis constant (Km) for methionine.	Methionine	178-188	methionine adenosyltransferase 2B	Homo sapiens	13-18
26940012-2	2016	The MAT2B protein with MAT2alpha catalyzes the formation of methyl donor S- adenosylmethionine (SAMe) to mediate cell metabolism including proliferation and apoptosis.	S-Adenosylmethionine	73-94	methionine adenosyltransferase 2B	Homo sapiens	4-9
26940012-8	2016	Moreover, the inhibitory effect of LY294002 (a specific PI3K inhibitor) on the activities of AKT and ERK1/2 was partially recovered by overexpression of MAT2B in porcine intramuscular adipocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	methionine adenosyltransferase 2B	Homo sapiens	153-158
23425511-6	2013	The structure of MAT2B reveals an SDR (short-chain dehydrogenase/reductase) core with specificity for the NADP/H cofactor, and harbours the SDR catalytic triad (YxxxKS).	NADP	106-110	methionine adenosyltransferase 2B	Homo sapiens	17-22
23425511-7	2013	Extended from the MAT2B core is a second domain with homology with an SDR sub-family that binds nucleotide-sugar substrates, although the equivalent region in MAT2B presents a more open and extended surface which may endow a different ligand/protein-binding capability.	nucleotide-sugar	96-112	methionine adenosyltransferase 2B	Homo sapiens	18-23
22649255-7	2012	A gene x folate interaction (MAT2B) and 2 gene x vitamin B-12 interactions (BHMT, SLC25A32) reached the FDR P-adjusted <=2.00 x 10(-1) threshold.	Vitamin B 12	49-61	methionine adenosyltransferase 2B	Homo sapiens	29-41
23189196-0	2012	NADP+ binding to the regulatory subunit of methionine adenosyltransferase II increases intersubunit binding affinity in the hetero-trimer.	NADP	0-5	methionine adenosyltransferase 2B	Homo sapiens	43-76
23189196-1	2012	Mammalian methionine adenosyltransferase II (MAT II) is the only hetero-oligomer in this family of enzymes that synthesize S-adenosylmethionine using methionine and ATP as substrates.	S-Adenosylmethionine	123-143	methionine adenosyltransferase 2B	Homo sapiens	10-43
23189196-1	2012	Mammalian methionine adenosyltransferase II (MAT II) is the only hetero-oligomer in this family of enzymes that synthesize S-adenosylmethionine using methionine and ATP as substrates.	S-Adenosylmethionine	123-143	methionine adenosyltransferase 2B	Homo sapiens	45-51
31293025-2	2019	MAT2A and MAT2B coordinately catalyzes the synthesis of the major biological methyl donor S-adenosylmethionine (SAMe).	S-Adenosylmethionine	90-110	methionine adenosyltransferase 2B	Homo sapiens	10-15
31293025-8	2019	Moreover, the inhibitory effect of U0126 (a specific ERK1/2 inhibitor) on the ERK1/2 activities was partially recovered by overexpression of MAT2A and MAT2B in porcine intramuscular preadipocytes.	U 0126	35-40	methionine adenosyltransferase 2B	Homo sapiens	151-156
31354356-1	2019	Background: In conjunction with the methionine adenosyltransferase 2A (MAT2A), MAT2B protein catalyses the formation of methyl donor S-adenosylmethionine to mediate cell metabolism, including proliferation and apoptosis.	S-Adenosylmethionine	133-153	methionine adenosyltransferase 2B	Homo sapiens	79-84
28553945-4	2017	We identified a Mat2A inhibitor, PF-9366, that binds an allosteric site on Mat2A that overlaps with the binding site for the Mat2A regulator, Mat2B.	pyrazofurin	33-35	methionine adenosyltransferase 2B	Homo sapiens	142-147
28553945-7	2017	These data support a model whereby Mat2B functions as an inhibitor of Mat2A activity when methionine or SAM levels are high, yet functions as an activator of Mat2A when methionine or SAM levels are low.	Methionine	90-100	methionine adenosyltransferase 2B	Homo sapiens	35-40
28553945-7	2017	These data support a model whereby Mat2B functions as an inhibitor of Mat2A activity when methionine or SAM levels are high, yet functions as an activator of Mat2A when methionine or SAM levels are low.	Methionine	169-179	methionine adenosyltransferase 2B	Homo sapiens	35-40
28337758-4	2017	Met and S-nitrosoglutathione inhibit MAT-II activity, and the MI decreases after Met stimulation of HepG2 cells.	S-Nitrosoglutathione	8-28	methionine adenosyltransferase 2B	Homo sapiens	37-43
23814050-0	2013	Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells.	Resveratrol	98-109	methionine adenosyltransferase 2B	Homo sapiens	0-38
23814050-3	2013	Interestingly, crystal structure analysis of MAT2B protein (MATbeta) protomer revealed two resveratrol binding pockets, which raises the question of the role of MAT2B in resveratrol biological activities.	Resveratrol	91-102	methionine adenosyltransferase 2B	Homo sapiens	45-50
23814050-5	2013	Following resveratrol treatment, HuR expression increased first, followed by SIRT1 and MAT2B.	Resveratrol	10-21	methionine adenosyltransferase 2B	Homo sapiens	87-92
23814050-10	2013	Induction of MAT2B is a compensatory response to resveratrol as knocking down MAT2BV1 potentiated the resveratrol pro-apoptotic and growth-suppressive effects, whereas the opposite occurred with V1 overexpression.	Resveratrol	49-60	methionine adenosyltransferase 2B	Homo sapiens	13-18
23814050-10	2013	Induction of MAT2B is a compensatory response to resveratrol as knocking down MAT2BV1 potentiated the resveratrol pro-apoptotic and growth-suppressive effects, whereas the opposite occurred with V1 overexpression.	Resveratrol	102-113	methionine adenosyltransferase 2B	Homo sapiens	13-18
23814050-12	2013	In conclusion, resveratrol induces HuR, SIRT1, and MAT2B expression; the last may represent a compensatory response against apoptosis and growth inhibition.	Resveratrol	15-26	methionine adenosyltransferase 2B	Homo sapiens	51-56
23189196-1	2012	Mammalian methionine adenosyltransferase II (MAT II) is the only hetero-oligomer in this family of enzymes that synthesize S-adenosylmethionine using methionine and ATP as substrates.	Adenosine Triphosphate	165-168	methionine adenosyltransferase 2B	Homo sapiens	10-43
23189196-1	2012	Mammalian methionine adenosyltransferase II (MAT II) is the only hetero-oligomer in this family of enzymes that synthesize S-adenosylmethionine using methionine and ATP as substrates.	Adenosine Triphosphate	165-168	methionine adenosyltransferase 2B	Homo sapiens	45-51
23189196-9	2012	Finally, the implications that the presence of different N-terminals in the beta subunit could have on MAT II behavior are discussed in light of the recent identification of several splicing forms of this subunit in hepatoma cells.	Nitrogen	57-58	methionine adenosyltransferase 2B	Homo sapiens	103-109
15963701-5	2005	Application of the characteristics of transformed hepatocytes to our model, i.e., substitution of the MAT I/III isozyme by MAT II, loss of GNMT activity and activation of polyamine biosynthesis, leads to the prediction of a significantly different dependence of methionine metabolism on methionine concentrations.	Methionine	262-272	methionine adenosyltransferase 2B	Homo sapiens	123-129
15963701-5	2005	Application of the characteristics of transformed hepatocytes to our model, i.e., substitution of the MAT I/III isozyme by MAT II, loss of GNMT activity and activation of polyamine biosynthesis, leads to the prediction of a significantly different dependence of methionine metabolism on methionine concentrations.	Methionine	287-297	methionine adenosyltransferase 2B	Homo sapiens	123-129
18753136-2	2008	Using RNA interference gene silencing technology, we modulated the kinetics of methionine adenosyltransferase-II (MAT-II), which catalyzes SAMe synthesis from ATP and l-Met.	Adenosine Triphosphate	159-162	methionine adenosyltransferase 2B	Homo sapiens	79-112
18753136-2	2008	Using RNA interference gene silencing technology, we modulated the kinetics of methionine adenosyltransferase-II (MAT-II), which catalyzes SAMe synthesis from ATP and l-Met.	Adenosine Triphosphate	159-162	methionine adenosyltransferase 2B	Homo sapiens	114-120
18753136-2	2008	Using RNA interference gene silencing technology, we modulated the kinetics of methionine adenosyltransferase-II (MAT-II), which catalyzes SAMe synthesis from ATP and l-Met.	Methionine	167-172	methionine adenosyltransferase 2B	Homo sapiens	79-112
18753136-2	2008	Using RNA interference gene silencing technology, we modulated the kinetics of methionine adenosyltransferase-II (MAT-II), which catalyzes SAMe synthesis from ATP and l-Met.	Methionine	167-172	methionine adenosyltransferase 2B	Homo sapiens	114-120
18753136-4	2008	These effects were reversed at unphysiologically high l-Met (>50 microm), indicating that diminished leukemic cell growth at physiologic l-Met levels was a direct result of the increase in MAT-II K(m L-Met) due to MAT-IIbeta ablation and the consequent reduction in SAMe synthesis.	Methionine	54-59	methionine adenosyltransferase 2B	Homo sapiens	192-198
18753136-4	2008	These effects were reversed at unphysiologically high l-Met (>50 microm), indicating that diminished leukemic cell growth at physiologic l-Met levels was a direct result of the increase in MAT-II K(m L-Met) due to MAT-IIbeta ablation and the consequent reduction in SAMe synthesis.	Methionine	140-145	methionine adenosyltransferase 2B	Homo sapiens	192-198
18041713-10	2008	Treatment with SAMe or its metabolite methylthioadenosine (MTA) lowered expression of MAT2A and MAT2beta and blocked leptin-induced signaling, including an increase in MAT gene expression and growth.	5'-methylthioadenosine	38-57	methionine adenosyltransferase 2B	Homo sapiens	96-104